Miracle-dz/UniFAR-FTUs huggingface dataset:
Odd-frequency superconducting states with different types of Meissner response: Problem of coexistence

We consider physical properties of a superconductor with a recently proposed type of odd-frequency pairing that exhibits diamagnetic Meissner response (``odd-dia state''). Such a state was suggested in order to address stability issues arising in an odd-frequency superconducting state with paramagnetic Meissner response (``odd-para state''). Assuming the existence of an odd-dia state (due to a proper retarded interaction), we study its coexistence with an odd-para state. The latter is known to be generated as an induced superconducting component in, e.g., singlet superconductor/ferromagnet proximity structures or triplet superconductor/normal metal systems. Calculating the superfluid density of the mixed odd-para/odd-dia state and the Josephson current between the odd-para and odd-dia states, we find that the expressions for the currents in both cases have nonvanishing imaginary contributions and are therefore unphysical. We show that a realization of the odd-dia state implies the absence of a Hamiltonian description of the system, and suggest that there exists no physically realizable perturbation that could give rise to the spontaneous symmetry breaking necessary for an actual realization of the odd-dia superconducting state.
Is there a diurnal variation in repeated sprint ability on a non-motorised treadmill?

In active males, muscle force production and short-term (<6 s) anaerobic performance are significantly greater in the evening compared with the morning. This diurnal variation is attributed to motivational, peripheral and central factors, and possibly the higher core and muscle temperatures observed in the evening. However, little is known regarding whether diurnal variation on a treadmill also exists in team-sport specific tests of repeated sprint ability (RSA), as would be relevant to football, for example. A controlled laboratory protocol using a non-motorised treadmill has been used to investigate whether daily variation in RSA is present in highly motivated athletes. Twenty active males (mean ± SD: age, 21.0 ± 2.2 yrs; maximal oxygen uptake ( max), 60.8 ± 4.8 ml kg min−1; body mass, 77.02 ± 10.5 kg and height, 1.79 ± 0.07 m) volunteered and completed two sessions counterbalanced in order of administration (separated by >48 h): a morning (M, 07:30 h) and evening (E, 17:30 h) session. Both sessions included a 5-min active warm-up on a motorised treadmill at 10 km h−1 followed by three task-specific warm-up sprints at 50%, 70% and 80%, respectively, on a non-motorised treadmill. During each trial, 10 × 3 s repeated sprints with 30 s recoveries were performed on the non-motorised treadmill. Rectal (Trec) and muscle temperature measurements (Tm) were taken after subjects had reclined for 30 min at the start of the protocol, and again after the active warm-up. Values of heart rate, thermal comfort (TC), rating of perceived exertion (RPE) and effort were measured throughout. Blood samples were taken at rest, after the sprints and 5-min post sprints. Data were analysed using a GLM with repeated measures. Trec and Tm values were higher at rest in the evening than the morning (0.46 °C and 0.57 °C, respectively, p < 0.05). Distance covered, peak power, average power, peak velocity and average velocity all showed significantly higher values in the evening compared with the morning (a range of 3.3–8.3%, p < 0.05), with peak power displaying a statistical trend (0.10 > p > 0.05). All subjects reported maximal values for “effort” for each sprint. There were significant positive correlations between Trec and Tm, Trec and RPE, TC and all measures of RSA performance. However, there was no correlation between fatigue index for peak power output or peak velocity and Trec. In summary, in this population of motivated subjects, time-of-day effects were seen in resting Trec and Tm values and all performance measures of RSA, in partial agreement with past research. The diurnal variation in Trec and Tm cannot fully explain time-of-day oscillations in RSA on a non-motorised treadmill. Although central temperature may provide some endogenous rhythm to human performance, the causal link seems to be due to a multiplicity of components and mechanisms.
Atmospheric molding of ionic copolymer MALDI‐TOF/MS arrays: A new tool for protein identification/profiling

An atmospheric molding protocol has been used to prepare an ionic methacrylate‐based copolymer sample support chips for MALDI (pMALDI)‐MS by targeting selected groups of various monomers copolymerized during molding, namely, carboxy, sulfo, dimethylalkyamino, and trimethylalkylammonium groups. The new disposable array chips provide analyte‐oriented enhancement of protein adsorption to the modified substrates without requiring complicated surface coating or derivatization. The MALDI‐MS performance of the new ionic copolymer chips was evaluated for lysozyme, β‐lactoglobulin A, trypsinogen and carbonic anhydrase I using washing with solutions prepared in pH or ionic strength steps. On cationic chips, the proteins are washed out at pH lower than their pI values, and on anionic chips at pH higher than their pI values. The ability of the microfabricated pMALDI chip set to selectively adsorb different proteins from real samples and to significantly increase their MS‐signal was documented for the transmembrane photosystem I protein complex from the green alga Chlamydomonas reinhardtii. The proteins were almost exclusively adsorbed according to calculated pI values and grand average of hydropathy (GRAVY) indexes. The new disposable chips reduce manipulation times and increase measurement sensitivity for real‐world proteomic samples. The simple atmospheric molding procedure enables additional proteomic operations to be incorporated on disposable MALDI‐MS integrated platforms.
Effects of Singulair (montelukast) treatment for capsular contracture.

BACKGROUND Capsular contracture (CC) is one of the most common complications of breast augmentation surgery. Leukotrienes are implicated in the inflammatory cascade and have been postulated to be involved in the formation of CC. Therefore, leukotriene antagonists Accolate and Singulair have been prescribed by plastic surgeons off-label to treat and prevent CC. To date, there are no studies investigating the efficacy of Singulair on CC. OBJECTIVE The authors retrospectively review a series of patients treated with Singulair to determine whether it improves CC after breast implant surgery. METHODS Nineteen patients treated with Singulair by the senior surgeon (NH) after implant placement from March 2006 to November 2009 were included in this study. Follow-up on Singulair efficacy was obtained by a combination of office chart review and standardized telephone questionnaire. Results were characterized as complete improvement, improvement, no change, or worse. RESULTS Seventeen patients presented with CC resulting from a variety of breast operations. Two patients who had a history of recurrent CC were prescribed Singulair prophylactically immediately after surgery. Twenty-one breasts with existing CC were included in the total. Two (11%) patients became worse, three (16%) patients had no change, five (26%) improved, seven (37%) completely improved, and two (11%) were prevented from having CC formation. CONCLUSION Our preliminary study shows that Singulair improves CC. Breasts with mild CC (Baker score < III) appeared to have better improvement with Singulair compared to those with more severe contracture (Baker score III and IV). Singulair is well tolerated with minimal side effects and can be administered to patients after breast implant surgery to improve CC.
The Protestant Legacy: Missions and Literacy in India

As an important expression of culture, religion represents a possible fundamental source of economic and social outcomes. This paper investigates how the historical development of Protestantism may contribute to explain current literacy disparities in India. In order to enable everyone to read the Bible by themselves, Protestants have always stressed the importance of promoting universal literacy. Combining information about the spatial distribution of Protestant missions in India at the end of the nineteenth century with contemporary district-level data, this paper documents a strong long-term relationship between the historical exposure to Protestant missions and current literacy. This pattern does not depend on either local geographic characteristics or the level of historical development of the districts. By exploiting only the variation within groups of geographically contiguous districts and using historical Catholic missions as control group, I verify that this relationship is not driven by unobserved characteristics that may affect both current literacy outcomes as well as the missionaries’ location decisions.
Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans.

The rates of protein synthesis and degradation and of amino acid transport were determined in the leg muscle of untrained postabsorptive normal volunteers at rest and approximately 3 h after a resistance exercise routine. The methodology involved use of stable isotopic tracers of amino acids, arteriovenous catheterization of the femoral vessels, and biopsy of the vastus lateralis muscle. During postexercise recovery, the rate of intramuscular phenylalanine utilization for protein synthesis increased above the basal value by 108 +/- 18%, whereas the rate of release from proteolysis increased by 51 +/- 17%. Muscle protein balance improved (P < 0.05) after exercise but did not become positive (from -15 +/- 12 to -6 +/- 3 nmol phenylalanine.min-1.100 ml leg volume-1). After exercise, rates of inward transport of leucine, lysine, and alanine increased (P < 0.05) above the basal state from 132 +/- 16 to 208 +/- 29, from 122 +/- 8 to 260 +/- 8, and from 384 +/- 71 to 602 +/- 89 nmol.min-1.100 ml leg-1, respectively. Transport of phenylalanine did not change significantly. These results indicate that, during recovery after resistance exercise, muscle protein turnover is increased because of an acceleration of synthesis and degradation. A postexercise acceleration of amino acid transport may contribute to the relatively greater stimulation of protein synthesis.
Is work—family balance more than conflict and enrichment?

This study deepens our theoretical and practical understanding of work—family balance, defined as the ‘accomplishment of role-related expectations that are negotiated and shared between an individual and his/her role-related partners in the work and family domains’ (Grzywacz & Carlson, 2007: 458). We develop a new measure of work—family balance and establish discriminant validity between it, work—family conflict, and work—family enrichment. Further, we examine the relationship of work—family balance with six key work and family outcomes. Results suggest that balance explains variance beyond that explained by traditional measures of conflict and enrichment for five of six outcomes tested: job satisfaction, organizational commitment, family satisfaction, family performance, and family functioning. We conclude with a discussion of the applications of our work.
A Trial of D-Cycloserine to Treat Stereotypies in Older Adolescents and Young Adults With Autism Spectrum Disorder

ObjectivesAutism spectrum disorders (ASDs) have core impairments in social communication as well as the presence of repetitive, stereotypic behaviors and restricted interests. Older adolescents and young adults are particularly impacted by these deficits. Preclinical data implicate glutamatergic dysfunction in the pathophysiology of ASDs. D-Cycloserine (DCS), a partial glycineB agonist at the N-methyl-D-aspartic acid receptor site, has been shown to improve sociability in mouse models and a small human study. The sensitivity of the obligatory glycineB co-agonist binding site may change with daily administration of DCS as a result of agonist-induced desensitization. The efficacy of a “pulsed” once-weekly administration versus “daily” administration of DCS was compared. MethodsMales and females, ages 14 to 25 years, with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision diagnosis of an ASD were enrolled in a double-blind, randomized 10-week trial consisting of 8 weeks of active drug with either weekly or daily administration of 50 mg of DCS followed by a 2-week follow-up visit. ResultsFor the purposes of this study, no statistical or clinical differences existed between the 2 dosage groups on the Aberrant Behavior Checklist subscale 3, which measures stereotypies/repetitive movements. When combining groups, a statistically significant decrease of 37% was found from baseline to week 8 when study drug was completed using a linear mixed effects model (P = 0.003). ConclusionsD-Cycloserine was shown to be effective in improving stereotypic symptoms in older adolescents and young adults with ASDs measured by the Aberrant Behavior Checklist subscale 3. In addition, DCS was safe and well tolerated.
E-Business IT Governance Revisited: An Attempt towards Outlining a Novel Bi-directional Business/IT Alignment in COBIT5

In contrast to classical business, e-business highly depends on internet technologies. Business and IT naturally coalesce here. Thus, a customer-driven IT requirement may enforce an adjustment of a business model. This poses new challenges for researchers and practitioners as currently a business-driven alignment paradigm dominates in IT governance. We identify characteristics of e-business and examine how IT governance frameworks can integrate these characteristics under consideration of a bi-directional business/IT alignment process. We use COBIT 5 as a benchmark for our examination, and reveal a need for a modification of the framework to fully cover e-business requirements. Based on the COBIT 5 Goal Cascade, we propose a possible integration of a bottom-up requirements process. Our findings for e-business can build a basis for future research on different business models.
Nearwork-Induced Transient Myopia and Parental Refractive Error

Purpose. To investigate the relationship between parental refractive error and the nearwork-induced transient myopia (NITM) characteristics of their children. Methods. Three hundred sixty children (173 boys and 187 girls) aged 6 to 17 years were tested. Initial NITM and its decay time (DT) were assessed objectively (WAM-5500, Grand-Seiko) immediately after binocularly viewing and performing a sustained near task (5 diopters [D]) for 5 minutes, incorporating a cognitive demand with full distance refractive correction in place. The NITM was classified into three categories: low (< 0.15 D), moderate (0.15 to 0.30 D), or high (≥0.30 D), whereas its decay was classified into two categories, namely, complete or incomplete. In addition, the children were divided into three groups based on the number of myopic parents (none, one, or two) and into four groups based on the level of parental myopia (no, low, moderate, or high). Results. Neither paternal nor maternal refractive error was associated with either their children’s initial NITM magnitude or its DT in the myopic, emmetropic, or hyperopic groups or the combined group. No significant differences (p > 0.05) in the NITM magnitude, DT, or decay time constant were found as related to the number of myopic parents or level of parental myopia. Multiple odds ratio for incomplete decay of NITM did not change significantly (p > 0.05) with either an increase in number of myopic parents or level of parental myopia. Conclusions. There was no association between parental refractive error and their children’s NITM characteristics. This suggests a primary environmental basis for the NITM characteristics in the children.
Information in the sample covariate distribution in prevalent cohorts

Methods of estimation and inference about survival distributions based on length‐biased samples are well‐established. Comparatively little attention has been given to the assessment of covariate effects in the context of length‐biased samples, but prevalent cohort studies often have this objective. We show that, like the survival distribution, the covariate distribution from a prevalent cohort study is length‐biased, and that this distribution may contain parametric information about covariate effects on the survival time. As a result, a likelihood based on the joint distribution of the survival time and the covariates yields estimates of covariate effects which are at least as efficient as estimates arising from a traditional likelihood which conditions on covariate values in the length‐biased sample. We also investigate the empirical bias of estimators arising from a joint likelihood when the population covariate distribution is misspecified. The asymptotic relative efficiencies and empirical biases under model misspecification are assessed for both proportional hazards and accelerated failure time models. The various methods considered are applied in an illustrative analysis of risk factors for death following onset of dementia using data collected in the Canadian Study of Health and Aging. Copyright © 2011 John Wiley & Sons, Ltd.
In Vitro and in Vivo Pharmacological Characterization of BM-613 [N-n-Pentyl-N′-[2-(4′-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a Novel Dual Thromboxane Synthase Inhibitor and Thromboxane Receptor Antagonist

Thromboxane A2 (TXA2) is a key mediator of platelet aggregation and smooth muscle contraction. Its action is mediated by its G protein-coupled receptor of which two isoforms, termed TPα and TPβ, occur in humans. TXA2 has been implicated in pathologies such as cardiovascular diseases, pulmonary embolism, atherosclerosis, and asthma. This study describes the pharmacological characterization of BM-613 [N-n-pentyl-N′-[2-(4′-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a new combined TXA2 receptor antagonist and TXA2 synthase inhibitor. It exhibits a strong affinity for human platelet TP receptors (IC50 = 1.4 nM), TPα and TPβ expressed in COS-7 cells (IC50 = 2.1 and 3.1 nM, respectively), and TPs expressed in human coronary artery smooth muscle cells (IC50 = 29 μM). BM-613 shows a weak ability to prevent contraction of isolated rat aorta (ED50 = 1.52 μM) and guinea pig trachea (ED50 = 2.5 μM) induced by TXA2 agonist U-46619 (9.11-dideoxy-9.11-methanoepoxy-prostaglandin F2). Besides, BM-613 antagonizes TPα (IC50 = 0.11 μM) and TPβ (IC50 = 0.17 μM) calcium mobilization induced by U-46619 and inhibits human platelet aggregation induced by U-46619 (ED50 = 0.278 μM), arachidonic acid (ED50 = 0.375 μM), and the second wave of ADP. BM-613 also dose dependently prevents TXA2 production by human platelets (IC50 = 0.15 μM). In a rat model of ferric chloride-induced thrombosis, BM-613 significantly reduces weight of formed thrombus by 79, 49, and 28% at 5, 2, and 1 mg/kg i.v. , respectively. In conclusion, BM-613 is a dual and potent TP receptor antagonist and TXA2 synthase inhibitor characterized by a strong antiplatelet and antithrombotic potency. These results suggest that BM-613 could be a potential therapeutic drug for thrombotic disorders.
Model for individualized prediction of breast cancer risk after a benign breast biopsy.

PURPOSE Optimal early detection and prevention for breast cancer depend on accurate identification of women at increased risk. We present a risk prediction model that incorporates histologic features of biopsy tissues from women with benign breast disease (BBD) and compare its performance to the Breast Cancer Risk Assessment Tool (BCRAT). METHODS We estimated the age-specific incidence of breast cancer and death from the Mayo BBD cohort and then combined these estimates with a relative risk model derived from 377 patient cases with breast cancer and 734 matched controls sampled from the Mayo BBD cohort to develop the BBD-to-breast cancer (BBD-BC) risk assessment tool. We validated the model using an independent set of 378 patient cases with breast cancer and 728 matched controls from the Mayo BBD cohort and compared the risk predictions from our model with those from the BCRAT. RESULTS The BBD-BC model predicts the probability of breast cancer in women with BBD using tissue-based and other risk factors. The concordance statistic from the BBD-BC model was 0.665 in the model development series and 0.629 in the validation series; these values were higher than those from the BCRAT (0.567 and 0.472, respectively). The BCRAT significantly underpredicted breast cancer risk after benign biopsy (P = .004), whereas the BBD-BC predictions were appropriately calibrated to observed cancers (P = .247). CONCLUSION We developed a model using both demographic and histologic features to predict breast cancer risk in women with BBD. Our model more accurately classifies a woman's breast cancer risk after a benign biopsy than the BCRAT.
The Veterans Health Administration and military sexual trauma.

OBJECTIVES We examined the utility of the Veterans Health Administration (VHA) universal screening program for military sexual violence. METHODS We analyzed VHA administrative data for 185,880 women and 4139888 men who were veteran outpatients and were treated in VHA health care settings nationwide during 2003. RESULTS Screening was completed for 70% of patients. Positive screens were associated with greater odds of virtually all categories of mental health comorbidities, including posttraumatic stress disorder (adjusted odds ratio [AOR]=8.83; 99% confidence interval [CI] = 8.34, 9.35 for women; AOR = 3.00; 99% CI = 2.89, 3.12 for men). Associations with medical comorbidities (e.g., chronic pulmonary disease, liver disease, and for women, weight conditions) were also observed. Significant gender differences emerged. CONCLUSIONS The VHA policies regarding military sexual trauma represent a uniquely comprehensive health care response to sexual trauma. Results attest to the feasibility of universal screening, which yields clinically significant information with particular relevance to mental health and behavioral health treatment. Women's health literature regarding sexual trauma will be particularly important to inform health care services for both male and female veterans.
A Review of Recent Approaches to Designing Fast Algorithms for Scheduling with Controllable Processing Times and Imprecise Computation

This paper provides a review of recent results on scheduling with controllable processing times. The stress is on the methodological aspects that include parametric flow techniques and methods for solving mathematical programming problems with submodular constraints. We show that the use of these methodologies results into fast algorithms for solving problems on single machine or parallel machines, with either one or several objective functions. For a wide range of problems with controllable processing times we report algorithms with the running times which match those known for the corresponding problems with fixed processing times. As a by-product, we present the best possible algorithms for a number of problems on parallel machines that are traditionally studied within the body of research on scheduling with imprecise computation.
The Transtheoretical Stages of Change Model and Motivational Interviewing for Building Maternal Supportiveness in Cases of Sexual Abuse

ABSTRACT When a child has been sexually abused, the non-offending parent plays a crucial role in determining that child's recovery. However, the disclosure of sexual abuse in families often throws non-offending parents into a dilemma about whether or not to side with the perpetrator or child, leaving them in an ambivalent position. In order to enhance the ability of parents to protect and support their children, this paper proposes the use of the Transtheoretical Stages of Change model and Motivational Interviewing. Techniques of Motivational Interviewing will be discussed and then illustrated with a case example.