Miracle-dz/UniFAR-FTUs huggingface dataset:
Disability 3, 12, and 24 Months After Traumatic Brain Injury Among Children and Adolescents

OBJECTIVE: To examine disability in children and adolescents after traumatic brain injury (TBI) across the spectrum of injury severity. METHODS: This was a prospective cohort study of children younger than 18 years treated for a TBI (n = 729) or an arm injury (n = 197) between March 1, 2007, and September 30, 2008. The main outcome measures were disability in health-related quality of life, adaptive skills, and participation in social and community activities 3, 12, and 24 months after injury compared with preinjury functioning. RESULTS: The health-related quality of life for children with moderate or severe TBI was lower at all follow-up times compared with baseline, but there was some improvement during the first 2 years after injury. Three months after injury, there was a substantial decrease in the level of activities in which children with moderate and severe TBI were able to participate; these activities improved at 12 and 24 months but were still significantly impaired. Communication and self-care abilities in children with moderate and severe TBI were lower at 3 months than at baseline and did not improve by 24 months. Children who met the definition of mild TBI but had an intracranial hemorrhage had lower quality-of-life scores at 3 months. CONCLUSIONS: Children with moderate or severe TBI and children with mild TBI who had intracranial hemorrhage had substantial long-term reduction in their quality of life, participation in activities with others, and ability to communicate and care for themselves.
General Practitioners' Discretion of Preventive Needs

This article examines general practitioners’ discretion in preventive contexts. Based on semi-structured interviews with 15 general practitioners, we examine how lifestyle is used in their discretionary practices in contexts of healthcare prevention. Despite common educational background and professional ideology, GPs’ do not share lifestyle and our analyses show that this matters to their discretion of patients’ need for lifestyle intervention. The correspondence between general practitioners’ preventive strategies and their own lifestyle preferences is interpreted as evidence of autonomy in general practice where general practitioners act relatively autonomously and differ in their interpretation of how preventive policies should be exercised in practice towards patients. Keywords : discretion, lifestyle, health prevention and promotion, street-level bureaucrats, general practitioners
Shared Decision-Making and Health Care Expenditures Among Children With Special Health Care Needs

Background And Objectives To understand the association between shared decision-making (SDM) and health care expenditures and use among children with special health care needs (CSHCN). Methods We identified CSHCN <18 years in the 2002–2006 Medical Expenditure Panel Survey by using the CSHCN Screener. Outcomes included health care expenditures (total, out-of-pocket, office-based, inpatient, emergency department [ED], and prescription) and utilization (hospitalization, ED and office visit, and prescription rates). The main exposure was the pattern of SDM over the 2 study years (increasing, decreasing, or unchanged high or low). We assessed the impact of these patterns on the change in expenditures and utilization over the 2 study years. Results Among 2858 subjects representing 12 million CSHCN, 15.9% had increasing, 15.2% decreasing, 51.9% unchanged high, and 17.0% unchanged low SDM. At baseline, mean per child total expenditures were $2131. Over the 2 study years, increasing SDM was associated with a decrease of $339 (95% confidence interval: $21, $660) in total health care costs. Rates of hospitalization and ED visits declined by 4.0 (0.1, 7.9) and 11.3 (4.3, 18.3) per 100 CSHCN, and office visits by 1.2 (0.3, 2.0) per child with increasing SDM. Relative to decreasing SDM, increasing SDM was associated with significantly lower total and out-of-pocket costs, and fewer office visits. Conclusions We found that increasing SDM was associated with decreased utilization and expenditures for CSHCN. Prospective study is warranted to confirm if fostering SDM reduces the costs of caring for CSHCN for the health system and families.
Mental Health Difficulties in Children With Developmental Coordination Disorder

OBJECTIVE: To explore the associations between probable developmental coordination disorder (DCD) defined at age 7 years and mental health difficulties at age 9 to 10 years. METHODS: We analyzed of prospectively collected data (N = 6902) from the Avon Longitudinal Study of Parents and Children. “Probable” DCD was defined by using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria as those children below the 15th centile of the Avon Longitudinal Study of Parents and Children Coordination Test, with functional limitations in activities of daily living or handwriting, excluding children with neurologic difficulties or an IQ <70. Mental health was measured by using the child-reported Short Moods and Feelings Questionnaire and the parent-reported Strengths and Difficulties Questionnaire. Multiple logistic regression models, with the use of multiple imputation to account for missing data, assessed the associations between probable DCD and mental health difficulties. Adjustments were made for environmental confounding factors, and potential mediating factors such as verbal IQ, associated developmental traits, bullying, self-esteem, and friendships. RESULTS: Children with probable DCD (N = 346) had an increased odds of self-reported depression, odds ratio: 2.08 (95% confidence interval: 1.36–3.19) and parent-reported mental health difficulties odds ratio: 4.23 (95% confidence interval: 3.10–5.77). The odds of mental health difficulties significantly decreased after accounting for verbal IQ, social communication, bullying, and self-esteem. CONCLUSIONS: Children with probable DCD had an increased risk of mental health difficulties that, in part, were mediated through associated developmental difficulties, low verbal IQ, poor self-esteem, and bullying. Prevention and treatment of mental health difficulties should be a key element of intervention for children with DCD.
A training algorithm for optimal margin classifiers

A training algorithm that maximizes the margin between the training patterns and the decision boundary is presented. The technique is applicable to a wide variety of the classification functions, including Perceptrons, polynomials, and Radial Basis Functions. The effective number of parameters is adjusted automatically to match the complexity of the problem. The solution is expressed as a linear combination of supporting patterns. These are the subset of training patterns that are closest to the decision boundary. Bounds on the generalization performance based on the leave-one-out method and the VC-dimension are given. Experimental results on optical character recognition problems demonstrate the good generalization obtained when compared with other learning algorithms.
Exocytosis, dependent on Ca2+ release from Ca2+ stores, is regulated by Ca2+ microdomains

The relationship between the cellular Ca2+ signal and secretory vesicle fusion (exocytosis) is a key determinant of the regulation of the kinetics and magnitude of the secretory response. Here, we have investigated secretion in cells where the exocytic response is controlled by Ca2+ release from intracellular Ca2+ stores. Using live-cell two-photon microscopy that simultaneously records Ca2+ signals and exocytic responses, we provide evidence that secretion is controlled by changes in Ca2+ concentration [Ca2+] in relatively large-volume microdomains. Our evidence includes: (1) long latencies (>2 seconds) between the rise in [Ca2+] and exocytosis, (2) observation of exocytosis all along the lumen and not clustered around Ca2+ release hot-spots, (3) high affinity (Kd =1.75 μM) Ca2+ dependence of exocytosis, (4) significant reduction in exocytosis in the prescence of cytosolic EGTA, (5) spatial exclusion of secretory granules from the cell membrane by the endoplasmic reticulum, and (6) inability of local Ca2+ responses to trigger exocytosis. These results strongly indicate that the control of exocytosis, triggered by Ca2+ release from stores, is through the regulation of cytosolic [Ca2+] within a microdomain.
Comparison of Sufentanil‐O2 and Fentanyl‐O2 for Coronary Artery Surgery

The cardiovascular responses, speed of anesthetic induction, incidence of chest wall rigidity, need for anesthetic supplements (phe-notolamine, N2O, and nitroprusside) to control intraoperative hy-pertension and speed of postoperative recovery were measured and compared in 37 patients undergoing coronary artery bypass grafting (CABG) operations with fentanyl-O2 (Group II) or sufentanil-O2 (Group II) anesthesia. After lorazepam-atropine premedication and pancuronium pretreatment, fentanyl was administered intravenously at 400 μg/min and sufentanil at 300 μg/min until patients were unconscious; at this time they were given succinylcholine and their tracheas were intubated. After intubation an amount of fentanyl or sufentanil equal to the dose producing unconsciousness was infused over the next 30 min, at which time the operation began. Additional fentanyl or sufentanil was given whenever systolic arterial blood pressure (SBP) increased more than 15 per cent of preanesthetic values. When three successive supplemental doses of the narcotic failed to effectively decrease SBP, phentolamine was used to control pressure before and during bypass; after bypass N2O (25–50 per cent) or, if N2O was ineffective, nitroprusside was used. Average time of induction was 4.6 · 0.5 and 1.3 · 0.3 min (mean · SD) for fentanyl and sufentanil, respectively. Chest wall rigidity occurred in 22 per cent of patients receiving fentanyl and 28 per cent of those receiving sufentanil. Total doses of fentanyl and sufentanil required for the entire operation were 122 · 15 and 12.9 · 0.5 (mean · SD) μg/kg, respectively. Heart rate, cardiac output, and mean right atrial pressure remained unchanged throughout the study in both groups. SBP was reduced slightly in both groups during induction but returned to control values prior to incision. Group II patients experienced no significant change in SBP after incision, sternotomy, or sternal spread, whereas SBP became significantly increased following sternal spread in patients given fentanyl. Phentolamine was required in 42 and 47 per cent of Group I patients before and during bypass, respectively, but in only 6 and 11 per cent of Group II patients. Fifty-three per cent of Group I patients required N2O, and 21 per cent required nitroprusside after bypass for blood pressure control. Only 11 per cent of Group II required N2O and 6 per cent required nitroprusside post-bypass. Hypertension requiring supplementation with phentolamine, N2O, or nitroprusside occurred more frequently in patients not taking preoperative beta-adrenergic blockers than in those taking these drugs in Group I. Hypertension requiring supplementaion never occurred in patients in Group II taking beta-blockers. The results of this study demonstrate that sufentanil may be a superior narcotic to fentanyl for use in patients undergoing CABG operations. The authors’ data also indicate that preoperative use of beta-adrenergic blocking durgs reduceds intraoperative hypertension with narcotic-oxygen anesthesia.
Prenatal Methamphetamine Exposure and Childhood Behavior Problems at 3 and 5 Years of Age

OBJECTIVE: We evaluated behavior problems in children who were prenatally exposed to methamphetamine (MA) at ages 3 and 5 years. METHODS: The Infant Development, Environment, and Lifestyle study, a prospective, longitudinal study of prenatal MA exposure and child outcome, enrolled subjects postpartum in Los Angeles, California; Honolulu, Hawaii; Des Moines, Iowa; and Tulsa, Oklahoma. Prenatal exposure was determined by maternal self-report and/or meconium results. Exposed and comparison groups were matched on race, birth weight, public health insurance, and education. Mothers in the comparison group denied use and had a negative meconium screen for amphetamines. Prenatal exposures to tobacco, alcohol, or marijuana occurred in both groups. At ages 3 and 5 years, 330 children (166 exposed and 164 comparison) were assessed for behavior problems by using the caregiver report on the Child Behavior Checklist. General linear mixed models were used to determine the effects of prenatal MA exposure, including heavy exposure (≥3 days per week), age, and the interaction of exposure and age on behavior problems with adjustment for other drugs of abuse and environmental risk factors. RESULTS: MA exposure was associated with increased emotional reactivity and anxious/depressed problems at both ages and externalizing and attention-deficit/hyperactivity disorder problems by age 5 years. Heavy exposure was related to attention problems and withdrawn behavior at both ages. There were no effects of MA on the internalizing or total behavior problems scales. CONCLUSIONS: This first report of behavior problems in patients as young as 3 years associated with MA exposure identifies an important public health problem. Continued follow-up can inform the development of preventive intervention programs.
Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment

Transforming acidic coiled-coil-containing protein 3 (TACC3) has been implicated in mitotic spindle assembly, although the mechanisms involved are largely unknown. Here we identify that clathrin heavy chain (CHC) binds specifically to phosphorylated TACC3 and recruits it to spindle poles for proper spindle assembly and chromosome alignment. Phosphorylation of Xenopus TACC3 at serine 620 (S620) and S626, but not S33, is required for its binding with CHC. Knockdown of CHC by RNA interference (RNAi) abolishes the targeting of TACC3 to spindle poles and results in abnormal spindle assembly and chromosome misalignment, similar to the defects caused by TACC3 knockdown. Furthermore, the binding of CHC with phosphorylated TACC3 is inhibited by importin β and this inhibition is reversed by the presence of the GTP-binding nuclear protein Ran in the GTP-bound state. Together, these results indicate that the recruitment of phosphorylated TACC3 to spindle poles by CHC ensures proper spindle assembly and chromosome alignment, and is regulated by Ran.
Stemming Indonesian: A confix-stripping approach

Stemming words to (usually) remove suffixes has applications in text search, machine translation, document summarization, and text classification. For example, English stemming reduces the words "computer," "computing," "computation," and "computability" to their common morphological root, "comput-. " In text search, this permits a search for "computers" to find documents containing all words with the stem "comput-. " In the Indonesian language, stemming is of crucial importance: words have prefixes, suffixes, infixes, and confixes that make matching related words difficult. This work surveys existing techniques for stemming Indonesian words to their morphological roots, presents our novel and highly accurate CS algorithm, and explores the effectiveness of stemming in the context of general-purpose text information retrieval through ad hoc queries.
Physical Activity of Children and Adolescents with a Disability: Methodology and Effects of Age and Gender

To date, very little published information has been available on the physical activity participation of disabled youth. A questionnaire, which was modified from the Canada Fitness Survey, was distributed by mail to physically disabled, sensory impaired, and chronically ill children and adolescents in Ontario, Canada. Nine hundred eighty-seven responses were collected from subjects 6 to 20 years of age, with a response rate of 58%. Twenty-nine percent of physically challenged youth were found to be sedentary, and 39% were active. Activity levels were significantly related to age (p < .01), with a marked decline in the second decade of life. Activity levels were not significantly influenced by gender, but the data suggest that girls have lower activity levels and a faster and earlier decline in activity than boys. Overall, the data collected provide baseline information on the role of physical activity in the lives of Ontario youth with physical disabilities, sensory impairments, and chronic illnesses.
Predictive user click models based on click-through history

Web search engines consistently collect information about users interaction with the system: they record the query they issued, the URL of presented and selected documents along with their ranking. This information is very valuable: It is a poll over millions of users on the most various topics and it has been used in many ways to mine users interests and preferences. Query logs have the potential to partially alleviate the search engines from thousand of searches by providing a way to predict answers for a subset of queries and users without knowing the content of a document. Even if the predicted result is at rank one, this analysis might be of interest: If there is enough confidence on a user's click, we might redirect the user directly to the page whose link would be clicked. In this paper, we present three different models for predicting user clicks, ranging from most specific ones (using only past user history for the query) to very general ones (aggregating data over all users for a given query). The former model has a very high precision at low recall values, while the latter can achieve high recalls. We show that it is possible to combine the different models to predict with high accuracy (over 90%) a high subset of query sessions (24% of all the sessions).
Arabidopsis RHD3 mediates the generation of the tubular ER network and is required for Golgi distribution and motility in plant cells

In plant cells, the endoplasmic reticulum (ER) and Golgi apparatus form a unique system in which single Golgi stacks are motile and in close association with the underlying ER tubules. Arabidopsis has three RHD3 (ROOT HAIR DEFECTIVE 3) isoforms that are analogous to the mammalian atlastin GTPases involved in shaping ER tubules. We used live-cell imaging, genetic complementation, split ubiquitin assays and western blot analyses in Arabidopsis and tobacco to show that RHD3 mediates the generation of the tubular ER network and is required for the distribution and motility of Golgi stacks in root and leaf epidermal cells. We established that RHD3 forms homotypic interactions at ER punctae. In addition, the activity of RHD3 on the tubular ER is specifically correlated with the cellular distribution and motility of Golgi stacks because ER to Golgi as well as Golgi to plasma membrane transport was not affected by RHD3 mutations in the conserved GDP/GTP motifs. We found a possible partial redundancy within the RHD3 isoforms in Arabidopsis. However, yeast Sey1p, a functional atlastin homologue, and RHD3 are not interchangeable in complementing the respective loss-of-function mutants, suggesting that the molecular mechanisms controlling ER tubular morphology might not be entirely conserved among eukaryotic lineages.
B-trees, shadowing, and clones

B-trees are used by many file systems to represent files and directories. They provide guaranteed logarithmic time key-search, insert, and remove. File systems like WAFL and ZFS use shadowing, or copy-on-write, to implement snapshots, crash recovery, write-batching, and RAID. Serious difficulties arise when trying to use b-trees and shadowing in a single system. This article is about a set of b-tree algorithms that respects shadowing, achieves good concurrency, and implements cloning (writeable snapshots). Our cloning algorithm is efficient and allows the creation of a large number of clones. We believe that using our b-trees would allow shadowing file systems to better scale their on-disk data structures.
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

Increasing evidence suggests that the interaction of misfolded protein oligomers with cell membranes is a primary event resulting in the cytotoxicity associated with many protein-misfolding diseases, including neurodegenerative disorders. We describe here the results of a study on the relative contributions to toxicity of the physicochemical properties of protein oligomers and the cell membrane with which they interact. We altered the amount of cholesterol and the ganglioside GM1 in membranes of SH-SY5Y cells. We then exposed the cells to two types of oligomers of the prokaryotic protein HypF-N with different ultrastructural and cytotoxicity properties, and to oligomers formed by the amyloid-β peptide associated with Alzheimer's disease. We identified that the degree of toxicity of the oligomeric species is the result of a complex interplay between the structural and physicochemical features of both the oligomers and the cell membrane.
Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment

Summary Fos plays essential roles in the osteoclastic differentiation of precursor cells generated by colony-stimulating factor 1 (CSF-1) and receptor activator of NF-&kgr;B ligand (RANKL; also known as tumor necrosis factor ligand superfamily member 11, Tnsf11). RANKL-deficient (RANKL−/−) mice and Fos−/− mice exhibit osteopetrosis due to an osteoclast deficiency. We previously reported that RANK-positive osteoclast precursors are present in bone of RANKL−/− mice but not Fos−/− mice. Here we report the role of Fos in RANK expression in osteoclast precursors. Medullary thymic epithelial cells and intestinal antigen-sampling microfold cells have been shown to express RANK. High expression of RANK was observed in some epithelial cells in the thymic medulla and intestine but not in osteoclast precursors in Fos−/− mice. RANK mRNA and protein levels in bone were lower in Fos−/− mice than RANKL−/− mice, suggesting that Fos-regulated RANK expression is tissue specific. When wild-type bone marrow cells were inoculated into Fos−/− mice, RANK-positive cells appeared along bones. RANK expression in wild-type macrophages was upregulated by coculturing with RANKL−/− osteoblasts as well as wild-type osteoblasts, suggesting that cytokines other than RANKL expressed by osteoblasts upregulate RANK expression in osteoclast precursors. CSF-1 receptor-positive cells were detected near CSF-1-expressing osteoblastic cells in bone in Fos−/− mice. CSF-1 upregulated RANK expression in wild-type macrophages but not Fos−/− macrophages. Overexpression of Fos in Fos−/− macrophages resulted in the upregulation of RANK expression. Overexpression of RANK in Fos−/− macrophages caused RANKL-induced signals, but failed to recover the RANKL-induced osteoclastogenesis. These results suggest that Fos plays essential roles in the upregulation of RANK expression in osteoclast precursors within the bone environment.