Miracle-dz/UniFAR-FTUs huggingface dataset:
Hemoglobin Polymorphism and Morphometrical Correlates in the West African Dwarf Sheep of Nigeria

Hematies extraidos de muestras de sangre tomadas por puncion venosa yugular de un total de treinta y seis carneros y ovejas enanas del oeste Africano, tradicionalmente manejadas como adultos, fueron sometidos a electroforesis en gel de almidon, y analizados mediante tincion para revelar las actividades de los morfoalelos en los diferentes locus de la hemoglobina. El objetivo del estudio fue examinar la variacion genetica, asi como el patron de segregacion en el locus, y develar la posible asociacion que puede existir entre los fenotipos y los rasgos zoometricos seleccionados. De los tres fenotipos teoricamente esperados a ser producidos en la poblacion por los dos alelos co-dominantes identificados, solo dos: HbAA y HbAB fueron observados. Las frecuencias genotipicas observadas se conformaron de acuerdo al equilibrio de Hardy-Weinberg. La proporcion de locis polimorficos fue 10,10%, mientras que la heterocigosidad (H) fue 0,218. La investigacion mostro que la segregacion mendeliana en los loci probados no fue congruente con los rasgos cuantitativos investigados vis-a-vis de longitud de cuernos y pelo. Los fenotipos de hemoglobina son independientes de las caracteristicas de la prueba.
The effect of equine-derived bone protein extract (Colloss-E) in the treatment of cavitary bone defects: an experimental study.

OBJECTIVE Bone protein extract (BPE) usually requires a carrier or a scaffold for implantation. We aimed to compare the effect of equine-derived BPE, an osteoinductive agent composed of a high amount of type-I collagen and other bone proteins (Colloss-E), with that of human demineralized bone matrix (DBM) for treating cavitary bone defects not requiring scaffold use. METHODS Rabbit distal femoral condyle was used as a stable cavitary bone defect model. Bone defects of 6-mm diameter and 10-12-mm depth were created in the femoral condyles. Rabbits were assigned into the equine-derived BPE (BPE), human-derived DBM (DBM), and control (C) groups. Approximately 20 mg of BPE was implanted into the defect in the equine-derived BPE group (n=6), whereas 0.3 cc of DBM was implanted in the DBM group (n=6). Defects were left empty in the C group (n=6). The defect area was histologically examined after 6 weeks. RESULTS There were no instances of macroscopic defect collapse or failure. Histopathological examination revealed that the BPE group had better scores (statistically significant) than both the other groups in terms of quality of union. The BPE group also had higher scores than the DBM group in terms of graft incorporation and new-bone formation. CONCLUSION The current study revealed results consistent with those of the previous studies concerning BPEs. Equine-derived BPE was found to be successful for treating cavitary bone defects not requiring scaffold use.
PENGARUH PROFITABILITAS, LIKUIDITAS, SIZE, KEPEMILIKAN INSTITUSIONAL, DAN TANGIBILITY TERHADAP STRUKTUR MODAL

This research is meant to test the influence of profitability, liquidity, firm size, institutional ownership, and assets structure to the capital structure. The population is all manufacturing companies which are listed in Indonesia Stock Exchange in 2012-2015 periods. The sample collection technique has been carried out by using purposive sampling method and based on the predetermined criteria, 63 companies have been selected as samples. The data of the financial statement of the companies has been obtained from the official website of IDX and Indonesian Capital Market Directory (ICMD). This research has been carried out by using classic assumption test and multiple linear regressions analysis test which has been performed by using the SPSS statistics test version 20.0. The result of the research shows that profitability and liquidity has negative influence to the capital structure. Institutional ownership and assets structure has positive influence to the capital structure. Meanwhile, firm size does not have any influence to the capital structure. The determination coefficient of the regression model which has been obtained is 0.807. It shows that the whole independent variables which influence the dependent variable is 80.7% and the remaining 19.3% is influenced by other variables which are not studied. Keywords: Performance Financial, Firm Size, Institutional Ownership, Assets Structure, Capital Structure.
Effects of Er:YAG laser and ultrasonic treatment on fibroblast attachment to root surfaces: an in vitro study.

BACKGROUND The aim of this study was to analyze the effects of erbium-doped:yttrium, aluminum, and garnet (Er:YAG) laser and ultrasonic treatment on fibroblast attachment to periodontally diseased root surfaces. METHODS Thirty single-rooted human periodontally involved teeth were included in this study. A total of 60 specimens were obtained from all selected teeth and were randomly assigned to the following three groups: group A, untreated control group; group B, ultrasonic group; and group C, Er:YAG laser at 160 mJ/pulse at 10 Hz group. All of the specimens were incubated in petri dishes with fibroblast suspension and observed by scanning electron microscopy. RESULTS Laser-treated specimens showed a significantly higher cell density number, with a mean+/-SD of 3,720+/-316 cells/mm2. The ultrasonically treated group showed a lower cell density number, with a mean+/-SD of 658+/-140 cells/mm2. The untreated control group showed the lowest cell density number, with a mean+/-SD of 130+/-80 cells/mm2. Differences between all groups were significant (P<0.0001). CONCLUSION The results of the study indicate that untreated control surfaces and ultrasonically treated surfaces exhibited a significantly lower number of attached cells compared to laser-treated specimens, which showed a significantly higher cell density number.
Electricity demand profile prediction based on household characteristics

This work proposes a methodology for predicting the typical daily load profile of electricity usage based on static data obtained from surveys. The methodology intends to: (1) determine consumer segments based on the metering data using the k-means clustering algorithm, (2) correlate survey data to the segments, and (3) develop statistical and machine learning classification models to predict the demand profile of the consumers. The developed classification models contribute to make the study and planning of demand side management programs easier, provide means for studying the impact of alternative tariff setting methods and generate useful knowledge for policy makers.
Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer.

BACKGROUND & AIMS The temporal association between diabetes mellitus and pancreatic cancer is poorly understood. We compared temporal patterns in diabetes prevalence in pancreatic cancer and controls. METHODS We reviewed the medical records of pancreatic cancer cases residing within 120 miles or less of Rochester, Minnesota, seen at the Mayo Clinic between January 15, 1981, and July 9, 2004, and approximately 2 matched controls/case residing locally. We abstracted all outpatient fasting blood glucose (FBG) levels for up to 60 months before index (ie, date of cancer diagnosis for cases) and grouped them into 12-month intervals; 736 cases and 1875 controls had 1 or more outpatient FBG levels in the medical record. Diabetes was defined as any FBG level of 126 mg/dL or greater or treatment for diabetes, and was defined as new onset when criteria for diabetes were first met 24 or fewer months before index, with at least 1 prior FBG level less than 126 mg/dL. RESULTS A higher proportion of pancreatic cancer cases compared with controls met the criteria for diabetes at any time in the 60 months before index (40.2% vs 19.2%, P < .0001). The proportions were similar in the -60 to -48 (P = .76) and -48 to -36 (P = .06) month time periods; however, a greater proportion of cases than controls met criteria for diabetes in the -36 to -24 (P = .04), -24 to -12 (P < .001), and -12 to 0 (P < .001) month time periods. Diabetes was more often new onset in cases vs controls (52.3% vs 23.6%, P < .0001). CONCLUSIONS Diabetes has a high (40%) prevalence in pancreatic cancer and frequently is new onset. Identification of a specific biomarker for pancreatic cancer-induced diabetes may allow screening for pancreatic cancer in new-onset diabetes.
Does the presence of anhydramnios affect the duration of medical abortion?

OBJECTIVES The aim of the study was to determine whether anhydramnios affected the duration of medical abortion in cases with various indications as compared to cases with normal amniotic fluid volume. MATERIAL AND METHODS Patients who were admitted to our clinic because of medical abortion between January 2010-December 2013 were included in this retrospective study. A total of 32 pregnant women with anhydramnios (study group) and 67 pregnant women with normal amniotic fluid volume but with fetal abnormality (control group) were included in the study. Patient age, gravidity, parity, gestational age, previous delivery route, and duration of the abortion were recorded. RESULTS Mean duration of the abortion in the study group was 71.93 ± 47.51 h as compared to 79.08 ± 52.62 h in the control group. There were no statistically significant differences between the two groups in terms of duration of the abortion (p = 0.516). Also, we found no statistically significant differences in duration of the abortion with regard to previous delivery route (p = 0.220). CONCLUSIONS There were no statistically significant differences between the study group and controls in terms of duration of the abortion. In addition, neither parity nor previous delivery route affected the duration of the abortion.
Dasar-dasar Penelitian Kualitatif : Tata langkah dan Teknik-teknik Teoritisasi Data

Judul asli : Basics of Qualitative Research. Grounded Theory Procedures and Techniques Buku ini membahas tentang masalah penelitian,kepekaan teoritik,penggunaan literatur,pengkodean berbuka,teknik-teknik untuk meningkatkan kepekaan teoritik,pengkodean berporos,pengkodean berpilih,proses,matrik kondisional,penyampelan teoritik,memo dan diagram,menyajikan hasil penelitian,kriteria penilaian terhadap penelitian Grounded Theory.
The services for children and adolescents-parent interview: development and performance characteristics.

OBJECTIVE To date, no instrument has been developed that captures children's services use across primary care, specialty mental health, and other settings, including setting, treatment type, provider discipline, and length and intensity of specific interventions over varying follow-up periods. The authors developed a highly structured services assessment measure [Services for Children and Adolescents-Parent Interview (SCAPI)] for use in the National Institute of Mental Health Multimodal Treatment Study of Children With Attention Deficit Hyperactivity Disorder (MTA). METHOD After successfully piloting and refining the SCAPI during initial phases of the MTA, the authors used this measure at 24 months post-randomization to ascertain the previous 6 months of services use for all participating (516 of 579) MTA children and families and 285 age- and gender-matched classroom control children. RESULTS Findings revealed meaningful, face-valid differences between MTA and control children in levels and types of services used during the previous 6-month period. Services use data reported by parents was substantially in accord with data independently gathered by the research data center. Site variations were found in the level and use of several specific services, such as individual child psychotherapy (sites ranged from 0% to 6.8% among classroom controls compared with 9.7% to 46.1% among MTA participants) and special education services (0% to 14.6% among classroom controls, 27.5% to 34.8% among MTA participants), consistent with differences reported in other studies. CONCLUSIONS These data support the descriptive validity of SCAPI-ascertained services use data and indicate that the SCAPI can provide investigators and policymakers a valid means of assessing services type, intensity, onset and offset, provider type, and content.
Epitope‐tagging Math5 and Pou4f2: New tools to study retinal ganglion cell development in the mouse

Although immunological detection of proteins is used extensively in retinal development, studies are often impeded because antibodies against crucial proteins cannot be generated or are not readily available. Here, we overcome these limitations by constructing genetically engineered alleles for Math5 and Pou4f2, two genes required for retinal ganglion cell (RGC) development. Sequences encoding a peptide epitope from haemagglutinin (HA) were added to Math5 or Pou4f2 in frame to generate Math5HA and Pou4f2HA alleles. We demonstrate that the tagged alleles recapitulated the wild‐type expression patterns of the two genes, and that the tags did not interfere with the function of the cognate proteins. In addition, by co‐staining, we found that Math5 and Pou4f2 were transiently co‐expressed in newly born RGCs, unequivocally demonstrating that Pou4f2 is immediately downstream of Math5 in RGC formation. The epitope‐tagged alleles provide new and useful tools for analyzing gene regulatory networks underlying RGC development. Developmental Dynamics 238:2309–2317, 2009. © 2009 Wiley‐Liss, Inc.
Life cycle stage effects, CEO power and internal control quality: evidence from listed family firms in China

Abstract We study the evolution of internal control quality within listed family firms in China, over different stages of the life cycle. We find a downward trend in internal control quality, and a significant difference between growth and non-growth stages. Further, we investigate the relationship between CEO power and internal control quality. In the growth stage, the higher the CEO’s structure power and expert power, the higher the internal control quality. In addition, the higher the CEO’s ownership power, the lower the internal control quality. But in the non-growth stage, a CEO’s expert power and ownership power is significantly negatively associated with the internal control quality. Additionally, the different types of CEO source in the family firm result in heterogeneity of CEO power. The findings show that the actual controller as CEO prefers weaker internal control quality and has a positive moderating effect on the association of expert power and the internal control quality. Where the CEO is related as a family member of the actual controller, then the closer is the kinship network and the lower is the internal control quality. Moreover, a closer kinship network increases the negative impact of ownership power on internal control quality.
Methylenetetrahydrofolate reductase polymorphisms at 3'-untranslated region are associated with susceptibility to preterm birth.

BACKGROUND Etiology and mechanism of preterm birth (PTB) is complicated. Genetic susceptibility is one of the key factors involved in the pathogenic mechanism underlying PTB. METHODS A subset of single nucleotide polymorphisms (SNPs) selected by bioinformatics approach from 3'-untranslated region (3'-UTR) of methylenetetrahydrofolate reductase (MTHFR) gene were subjected to SNaPshot analysis in a case-control study. Three SNPs (rs45451599, rs1537515, rs1537516) were simultaneously tested in one tube, among 1,135 DNA samples including 480 PTBs and 655 term controls. RESULTS Two perfectly correlated (r(2)=1) SNPs, rs1537515 and rs1537516, were found significantly associated with PTB susceptibility [P=0.012; OR: 0.65; 95% confidence interval (CI), 0.47-0.91]. The frequencies of the minor alleles were lower in PTB cases than in controls, which the frequencies were 0.066 in PTB cases and 0.095 in controls. G and T allele frequencies of rs1537515 were the same with rs1537516 (P=0.011; OR: 0.666; 95% CI, 0.49-0.91). Rs45451599 was not found associated with PTB (P=0.52; OR: 0.76; 95% CI, 0.33-1.74). The 18-25 nucleotides in length of microRNAs (miRNAs) which can regulate gene expressions are involved in binding partial complementary sequences within 3'-UTR. The two loci are at 3'-UTR of MTHFR mRNA. Rs1537516 is a potential target of miR-1304-3p, while rs1537515 is miR-1224-3p and miR-3150-5p. CONCLUSIONS In conclusion, rs1537515 and rs1537516 within the 3'-UTR of the MTHFR gene may be associated with susceptibility to PTB.
Individual Differences as Predictors of Social Networking

Research suggests that personality dictates specific Internet preferences. One area that remains relatively unexplored is the influence of personality on engagement with social networking sites SNSs. The current study employs a 'Uses and Gratifications' framework to investigate whether personality, age, and sex predict motivations for using SNSs. The study explores both global and specific factors of personality using Eysenck's EPQ-R short form extraversion, neuroticism and psychoticism and Beck's SAS sociotropy and autonomy. Principal component analysis identified ten distinct motivational components, which were then successfully predicted by individual differences through regression analyses. It is therefore suggested that individuals with different profiles vary in their motivations for using SNSs. Results support theoretical assumptions based on previous literature and personality dispositions.
Working capital requirements of manufacturing SMEs: evidence from emerging economy

The purpose of this paper is to analyze the effects of various factors like profitability, growth opportunity, financial leverage, assets tangibility, operating cash flows, age and size of firm on working capital requirements (WCR) of manufacturing SMEs in India. ,The paper uses a panel data regression model with fixed and random effect estimations. The data utilized in this study includes financial data of 254 manufacturing SMEs operating in India for the period 2010 to 2014. ,The overall results of the study indicate that operating cash flow, financial leverage, profitability, sales growth and asset tangibility are the key drivers of WCR for Indian manufacturing SMEs. Profitability of firm and sales growth are found to be positively related to WCR. In contrast, asset tangibility, operating cash flow and financial leverage are found to be negatively related to WCR. ,This paper investigates firm-specific factors while ignoring external factors like GDP growth, business indicators and industry type. Further research can be done to assess the effect of these external factors on WCR. ,This research contributes to the working capital literature by providing empirical evidence on determining factors of WCR in manufacturing SMEs.
Does Access to Finance Facilitates the Firm's Ability to Export? Experience from Asia-Pacific Countries

Financial development plays an important role in the structure of the trade balance and promoting economic development. Trade literature suggests that differences in economies’ endowments of labour, land, physical capital and technology explain the dynamics and patterns of international trade flows. More recent literature argues that it is the heterogeneity in productivity of firms which mainly accounts for the decision and survival in the international markets. Given the growing importance of Global Value Chains and Regional Production Networks in the emerging economies, financial development is essential to support credit facilities for the traders and provide hassle free transactions. In this context, this study attempts to examine the impact of access to finance on firms’ export decisions in the Asia-Pacific countries. In particular, we have studied whether financial development and institutional quality that support financial access promote international trade. The study found that access to finance plays a significant role in promoting firm’s ability to export. Unlike institutional quality, financial development indicators positively interact with access to finance to promote firm’s ability to export. The study also found that infrastructure bottlenecks negatively affect firms’ export decisions.
PEFR in relation to phases of pregnancy.

We wish to report PEFR changes during different trimesters of pregnancy. The study was conducted in collaboration with Department of Obstetrics and Gynaecology, Princess ESRA Hospital. Subjects belonging to same socioeconomic status, having normal Hb and BP were randomly picked up from antenatal clinic. A total number of 117 pregnant women (1, II and IIIrd. gravida) in the age group of 19-27 years were the subjects for this study. After asking the subjects to relax for 15 minutes, following paramenters were recorded: Height, Weight, BSA, EMI, RR, Chest expansion in respiration and PEFR. PEFR was studied using FERRARIS pocket peak flowmeter (1). Subjects were divided into three groups, i.e. Group 1 1st Trimester (n = 12), Group 2 lInd· Trimester (n = 35) and Group 3 IIII'd Trimester (n = 70).
Acoustic Analysis of Voices of Patients with Neurologic Disease: Rationale and Preliminary Data

This paper presents a rationale for acoustic analysis of voices of neurologically diseased patients, and reports preliminary data from patients with myotonic dystrophy, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis, as well as from individuals at risk for Huntington's disease. Noninvasive acoustic analysis may be of clinical value to the otolaryngologist, neurologist, and speech pathologist for early and differential diagnosis and for documenting disease progression in these various neurologic disorders.
Antigenic and Receptor Binding Properties of Enterovirus 68

ABSTRACT Increased detection of enterovirus 68 (EV68) among patients with acute respiratory infections has been reported from different parts of the world in the late 2000s since its first detection in pediatric patients with lower-respiratory-tract infections in 1962. However, the underlying molecular mechanisms for this trend are still unknown. We therefore aimed to study the antigenicity and receptor binding properties of EV68 detected in recent years in comparison to the prototype strain of EV68, the Fermon strain. We first performed neutralization (NT) and hemagglutination inhibition (HI) tests using antisera generated for EV68 strains detected in recent years. We found that the Fermon strain had lower HI and NT titers than recently detected EV68 strains. The HI and NT titers were also significantly different between strains of different genetic lineages among recently detected EV68 strains. We further studied receptor binding specificities of EV68 strains for sialyloligosaccharides using glycan array analysis. In glycan array analysis, all tested EV68 strains showed affinity for α2-6-linked sialic acids (α2-6 SAs) compared to α2-3 SAs. Our study demonstrates that emergence of strains with different antigenicity is the possible reason for the increased detection of EV68 in recent years. Additionally, we found that EV68 preferably binds to α2-6 SAs, which suggests that EV68 might have affinity for the upper respiratory tract. IMPORTANCE Numbers of cases of enterovirus 68 (EV68) infection in different parts of the world increased significantly in the late 2000s. We studied the antigenicity and receptor binding properties of recently detected EV68 strains in comparison to the prototype strain of EV68, Fermon. The hemagglutination inhibition (HI) and neutralization (NT) titers were significantly different between strains of different genetic lineages among recently detected EV68 strains. We further studied receptor binding specificities of EV68 strains for sialyloligosaccharides using glycan array analysis, which showed affinity for α2-6-linked sialic acids (α2-6 SAs) compared to α2-3 SAs. Our study suggested that the emergence of strains with different antigenicities was the possible reason for the increased detections of EV68 in recent years. Additionally, we revealed that EV68 preferably binds to α2-6 SAs. This is the first report describing the properties of EV68 receptor binding to the specific types of sialic acids.