Miracle-dz/UniFAR-FTUs huggingface dataset:
Decoy oligodeoxynucleotide against activator protein-1 reduces neointimal proliferation after coronary angioplasty in hypercholesterolemic minipigs.

OBJECTIVES We sought to demonstrate, in an appropriate animal model, that co-medication with a transcription factor-blocking agent limits restenosis after percutaneous transluminal coronary angioplasty (PTCA). BACKGROUND Enhanced synthesis in the vessel wall of endothelin-1 (ET-1), a powerful co-mitogen for vascular smooth muscle cells, appears to be one mechanism that promotes restenosis after PTCA. Deformation-induced expression of prepro-ET-1 is governed by the transcription factor, activator protein-1 (AP-1). METHODS An anti-AP-1 decoy oligodeoxynucleotide (dODN) strategy was devised in which the dODN-containing solution (20 nmol) was administered locally through a Dispatch catheter into the coronary arteries of hypercholesterolemic minipigs at the time of PTCA (AVE-GFX stent). RESULTS Treatment with an AP-1 dODN, mimicking the consensus binding site of the transcription factor, significantly reduced neointimal formation in the coronary arteries of hypercholesterolemic minipigs (n = 10 to 12), compared with vehicle-treated coronary arteries, after four weeks of follow-up (neointimal area 2.64 +/- 0.33 vs. 4.81 +/- 1.04 mm(2) [mean +/- SEM]; p < 0.05). This effect was maintained after eight weeks (neointimal area 2.04 +/- 0.22 mm(2); n = 3) and correlated with a reduction in both nuclear translocation of AP-1 and ET-1 synthesis in the vessel wall 48 h after PTCA (n = 4). In contrast, an AP-1 mutant dODN, to which the transcription factor does not bind, showed no effect on neointimal formation at either time point (n = 3 to 7). Moreover, a consensus dODN directed against CCAAT/enhancer binding protein (C/EBP), another deformation-sensitive transcription factor, did not significantly affect neointimal formation after four weeks (n = 3). CONCLUSIONS These findings demonstrate the feasibility, efficacy and specificity of the anti-AP-1 dODN approach to the treatment of restenosis, which principally but not exclusively targets deformation-induced ET-1 synthesis in the vessel wall. Provided that these findings can be extrapolated to the situation of patients with coronary artery disease, the observed extent of the inhibitory effect of the AP-1 dODN treatment suggests that this co-medication may greatly reduce the incidence of in-stent restenosis.
MONEY AND OUTPUT: A TEST OF REVERSE CAUSATION

This paper attempts to explain the correlation between money and output at various leads and lags with a model in which money is largely neutral and endogenously responds to output. Money is endogenous because both monetary policy and deposit creation are endogenous. Parameters are selected according to the simulated moments estimation technique. While the estimated model succeeds along some dimensions in matching properties of postwar U.S. data, its failure to match key patterns of lead-lag correlations seems to cast doubt on the ability of endogenous money determination, by itself, to quantitatively account for the observed money-output correlations. Copyright 1996 by American Economic Association.
Tax credits, labour participation and home production in the Netherlands

We set up a dynamic reduced form model of labour market participation for women who balance career and motherhood. The model accounts for the occurrence of future child birth and early retirement, and includes home production; however, it does not require the estimation of a structural model. Careful implementation of pension institutions can return optimal life patterns of participation without the need of a structural approach. The weaker theoretical framework is compensated by the rich spectrum of possible policy simulations. As illustration, we simulate the effect of two tax credits policy options on the hazard rate out of work.
How Do They Really Help? An Empirical Study of the Role of Different Information Sources in Building Brand Trust

ABSTRACT Previous research shows past experience contributes to consumers’ brand knowledge and affects consumers’ trust in the brand. However, little is known of the mechanism through which user experience influences brand trust. The present research examines how user experience affects brand trust in comparison with the effects of two other information sources: advertising and word of mouth (WOM) communication. The findings reveal that the three information sources have differential impacts on brand trust with user experience being the strongest influence. In addition, user experience was shown to affect brand trust both directly and indirectly, suggesting the mechanism of consumer trust formation varies with the sources of information. Implications of these findings for practitioners are discussed.
Association between acid suppressive therapy and spontaneous bacterial peritonitis in cirrhotic patients with ascites

Abstract Objective. Proton pump inhibitor (PPI) or histamine-2 receptor antagonist (H2RA) therapy may cause intestinal bacterial overgrowth and translocation. Therefore, acid suppressive therapy may increase the risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with ascites. Material and methods. A total of 176 cirrhotic patients with ascites who underwent diagnostic paracentesis between September 2004 and April 2009 were included in the analysis. Patients with gastrointestinal hemorrhage and/or antibiotic therapy within 2 weeks prior to hospital admission were excluded. SBP was defined as ≥250/mm3 polymorphonuclear white blood cells with or without a positive culture from the ascitic fluid. Eighty-three patients (mean age 56.1 years, 63 males) had SBP and 93 (mean age 54.7 years, 75 males) did not. Results. On the multivariate analysis, a Child–Pugh class C (OR = 2.890, 95% CI 1.443–5.786; p = 0.003), high MELD scores (≥20, OR = 3.540, 95% CI 1.155–10.849; p = 0.027), and PPI use (OR = 3.443, 95% CI 1.164–10.188; p = 0.025) were risk factors for SBP. H2RA was not associated with SBP. Conclusions. PPI use, as well as Child–Pugh class C and high MELD scores, was an independent risk factor for the development of SBP in cirrhotic patients with ascites. Further prospective studies are warranted to clarify this issue.
Ultrastructural immunocytochemical localization of the dopamine D2 receptor and tyrosine hydroxylase in the rat ventral pallidum

The mesopallidal dopamine system plays a role in locomotor activity and reward. To understand the potential contribution of the dopamine D2 receptor (D2R) to the action of dopamine in the ventral pallidum (VP), we used electron microscopic immunocytochemistry to examine the cellular and subcellular localization of an antipeptide antiserum against the D2R in both ventromedial and dorsolateral VP compartments. In each region the majority of the total D2R‐labeled profiles (n = 1,132) were axon terminals (55%) and small unmyelinated axons (27%). These terminals were often apposed to other axon terminals or dendrites and formed almost exclusively symmetric, inhibitory‐type axodendritic synapses. Immunogold D2R labeling in axon terminals was seen on the plasmalemma and membranes of nearby synaptic vesicles. In ventral pallidal sections processed for dual detection of D2R peptide and the catecholamine‐synthesizing enzyme tyrosine hydroxylase (TH), D2R labeling was detected in a few axons and axon terminals containing TH immunoreactivity as well as in axons contacted by TH‐labeled terminals. In most cases, however, the D2R‐labeled profiles were located at a distance from small axons and terminals containing TH. Our results provide the first ultrastructural evidence that D2Rs in the two VP subterritories are strategically located for primary involvement in modulation of the presynaptic release of nondopaminergic inhibitory transmitters. They also suggest that in this region the presynaptic D2 receptors are 1) minimally involved in autoregulation of dopaminergic transmission, and 2) differentially activated by dopamine, depending in part on levels and distance from release sites. Synapse 43:151–162, 2002. © 2002 Wiley‐Liss, Inc.
Analysis of cut points for screening instruments for alcohol problems in the emergency room.

OBJECTIVE The purpose of this study is to evaluate the performance of a number of alcohol screening instruments (CAGE, Brief MAST, AUDIT, TWEAK), in an emergency room population, against ICD-10 criteria for harmful drinking and for alcohol dependence from the CIDI, by gender, race and injury status. METHOD A probability sample of patients were interviewed (N = 1,330) at the University of Mississippi Medical Center. Analyses were carried out on only current drinkers (n = 771; 58% of the sample). Instruments were compared on sensitivity, specificity and area under the curve using receiver operating characteristic (ROC) analysis to determine optimum cut points. RESULTS Overall the TWEAK and AUDIT performed best (in relation to sensitivity and area under the ROC curve) at standard cut points (3 and 8, respectively) for both harmful drinking and alcohol dependence. These instruments did not perform equally well across all subgroups, however, particularly among women, and among whites where the CAGE, with a cut point of 1, outperformed both the TWEAK and AUDIT at standard cut points. The TWEAK at a cut point of 2 also did as well as the CAGE at a cut point of 1 among women. CONCLUSION These data suggest that standard screening instruments do not perform equally well across ethnic and gender subgroups and that consideration of alternative cut points may be appropriate in some populations.
Productive Government Spending and Private Consumption: A Pessimistic View

This paper analyses the consequences of productive government spending on private consumption. In a related work, Linnemann and Schabert (2006) found that a moderate output elasticity of government expenditures is sufficient to generate a positive consumption response to a fiscal shock. It is shown in this paper that pessimism as to the ability of productive government spending to account for an empirically observed positive consumption response is in order because a balanced budget increase in government spending increases private consumption only if the productivity of government spending is relatively high. For realistic values of the output elasticity of government spending, a positive consumption response is ruled out.
Regulation of actin-activated ATP hydrolysis by arterial myosin.

Myosin was isolated from the main pulmonary artery of swine and was phosphorylated or dephosphorylated by utilizing the endogenous kinase or phosphatase, respectively. The myosins, phosphorylated to various degrees, were purified free of kinase and phosphatase activities by gel filtration on Sepharose CL-4B agarose columns. The level of actin-activated ATPase activity was dependent upon the degree of myosin light chain phosphorylation. Fully phosphorylated myosin reconstituted with actin and tropomyosin (actin/tropomyosin = 61:1) had the highest ATPase activity (0.1 mumol of Pi/mg . min). The actin-activated ATPase activity showed maximal (60--65%) Ca2+ sensitivity at 2 mol of Ca2+ bound per mol of myosin. The actin-activated ATPase activity, Ca2+ binding, and Ca2+ sensitivity of arterial myosin were also dependent upon Mg2+ concentration. The ATPase activity was maximal at 2--3 mM Mg2+ and, at low (0.5 mM) Mg2+ concentration, the activity was only one-third of the maximal activity. Increasing the Mg2+ above 3 mM was not associated with a further increase in ATPase activity, but the Ca2+ binding and Ca2+ sensitivity decreased with increasing Mg2+ concentration. The maximal Ca2+ sensitivity was observed at 2--3 mM Mg2+, a concentration at which the myosin bound 2 mol of Ca2+/mol. Both the ATPase activity and the Ca2+ sensitivity were more remarkable when actin that contained tropomyosin was used to activate the ATPase activity. The data indicate that calcium regulates the actin-activated ATP hydrolysis not only by its effects on the phosphorylation system but also by direct binding to the myosin.
The minimum or natural rate of flow and droplet size ejected by Taylor cone–jets: physical symmetries and scaling laws

We aim to establish the scaling laws for both the minimum rate of flow attainable in the steady cone–jet mode of electrospray, and the size of the resulting droplets in that limit. Use is made of a small body of literature on Taylor cone–jets reporting precise measurements of the transported electric current and droplet size as a function of the liquid properties and flow rate. The projection of the data onto an appropriate non-dimensional parameter space maps a region bounded by the minimum rate of flow attainable in the steady state. To explain these experimental results, we propose a theoretical model based on the generalized concept of physical symmetry, stemming from the system time invariance (steadiness). A group of symmetries rising at the cone-to-jet geometrical transition determines the scaling for the minimum flow rate and related variables. If the flow rate is decreased below that minimum value, those symmetries break down, which leads to dripping. We find that the system exhibits two instability mechanisms depending on the nature of the forces arising against the flow: one dominated by viscosity and the other by the liquid polarity. In the former case, full charge relaxation is guaranteed down to the minimum flow rate, while in the latter the instability condition becomes equivalent to the symmetry breakdown by charge relaxation or separation. When cone–jets are formed without artificially imposing a flow rate, a microjet is issued quasi-steadily. The flow rate naturally ejected this way coincides with the minimum flow rate studied here. This natural flow rate determines the minimum droplet size that can be steadily produced by any electrohydrodynamic means for a given set of liquid properties.
Policy analysis of oral health promotion in South Africa

This article reports an analysis of oral health promotion in South African health policy. The central aim of this research was to determine the form and coherence of oral health promotion elements within health policies of post-apartheid South Africa. The study set out to test the hypothesis that oral health promotion elements are fully integrated into health policy and programmatic efforts. A conceptual framework was developed to systematically analyse oral health promotion policy and subsequent decision-making across the country at national and provincial levels. The information was drawn from policy documents, protocols and programme plans, complemented by interviews. The results indicate distinct contradictions between the policy formulation process and its impact on health system decision-making. South African health policy was found to be strong on the rhetoric of equity, health promotion, integration and several other features of the Primary Health Care Approach, but showed little evidence of translating this into action. The development and implementation of oral health promotion appears to be dominated by the influence of dental professionals that perpetuate a curative focus on service delivery. There is an urgent need to re-examine the process and content of oral health policy-making in South Africa. The conceptual framework developed for this study could facilitate further research in this area. (Global Health Promotion, 2010; 17(1): pp. 16—24)
Efficacy of Mobilization with Movement for Patients with Limited Dorsiflexion after Ankle Sprain: A Crossover Trial

Purpose: Although a primary goal of many manual therapy techniques is to improve joint range of motion (ROM), efficacy studies evaluating the effect of treatment on ROM are limited. The purpose of this study was to evaluate the effect of a talocrural joint mobilization-with-movement (MWM) technique on dorsiflexion ROM in participants demonstrating decreased range following lateral ankle sprain. Method: Twenty-three participants who had sustained unilateral ankle sprains within the past two years and exhibited a restriction in weight-bearing dorsiflexion participated in the study. We used a crossover design with random assignment to either a sham mobilization or an MWM technique. One week later, participants returned and received the alternate technique. Dorsiflexion was assessed using a weight-bearing lunge test. Results: The change in dorsiflexion following the MWM technique (0.63 6 0.89 cm) was significantly greater (p 5 0.02) than the change following the sham technique (0.18 6 0.35 cm). Conclusions: These findings suggest that a talocurual MWM improves ankle dorsiflexion immediately following treatment. Future research evaluating the effectiveness of multiple treatments on functional outcomes is warranted.
The American Jury and the Death Penalty

The reversal of civilized opinion on the death penalty during the past century and a half has been truly remarkable. It is an example of law in the process of radical change. ' As late as 1825 England had no less than 230 capital crimes on its law books. By the turn of the century legislative inroads had reduced the capital list to murder and treason, and, after an attempt to reduce it still further to certain types of murder, the English evolution has come to completion and the death penalty has now been abolished for all crimes.2 Although in England the death penalty, wherever applicable by statute, was mandatory on the trial process, the English jury played a major role in its gradual attenuation. On many occasions the jury simply refused to convict a clearly guilty defendant in order to
Tumor Vascular Area Correlates with Photosensitizer Uptake: Analysis of Verteporfin Microvascular Delivery in the Dunning Rat Prostate Tumor

Abstract The parameters that limit supply of photosensitizer to the cancer cells in a solid tumor were systematically analyzed with the use of microvascular transport modeling and histology data from frozen sections. In particular, the vascular permeability transport coefficient and the effective interstitial diffusion coefficient were quantified for Verteporfin-for-Injection delivery of benzoporphyrin derivative (BPD). Orthotopic tumors had higher permeability and diffusion coefficients (Pd = 0.036 μm/s and D = 1.6 μm2/s, respectively) as compared to subcutaneously grown tumors (Pd = 0.025 μm/s and D = 0.9 μm2/s, respectively), likely due to the fact that the vessel patterns are more homogeneous orthotopically. In general, large intersubject and intratumor variability exist in the verteporfin concentration, in the range of 25% in plasma concentration and in the range of 20% for tissue concentrations, predominantly due to these microregional variations in transport. However, the average individual uptake of photosensitizer in tumor tissue was only correlated to the total vascular area within the tumor (R2 = 64.1%, P < 0.001). The data are consistent with a view that microregional variation in the vascular permeability and interstitial diffusion rate contribute the spatial heterogeneity observed in verteporfin uptake, but that average supply to the tissue is limited by the total area of perfused blood vessels. This study presents a method to systematically analyze microheterogeneity as well as possible methods to increase delivery and homogeneity of photosensitizer within tumor tissue.
Vehicle License Plate Recognition With Random Convolutional Networks

Despite decades of research on automatic license plate recognition (ALPR), optical character recognition (OCR) still leaves room for improvement in this context, given that a single OCR miss is enough to miss the entire plate. We propose an OCR approach based on convolutional neural networks (CNNs) for feature extraction. The architecture of our CNN is chosen from thousands of random possibilities and its filter weights are set at random and normalized to zero mean and unit norm. By training linear support vector machines (SVMs) on the resulting CNN features, we can achieve recognition rates of over 98% for digits and 96% for letters, something that neither SVMs operating on image pixels nor CNNs trained via back-propagation can achieve. The results are obtained in a dataset that has 182 samples per digit and 28 per letter, and suggest the use of random CNNs as a promising alternative approach to ALPR systems.
Product Market Competition in Transition Economies: Increasing Varieties and Consumer Loyalty

This paper analyzes product market competition between foreign entrants and former SOEs in transition markets with respect to expansion of product variety and consumer loyalty formation. While the market share motive induces the more efficient foreign entrant to price aggressively, the extent of this behavior depends critically on its relative efficiency vis-a-vis the local incumbent. If the efficiency gap exceeds some threshold value, the entrant exploits increasingly its cost advantages by raising price rather than investing in market share. Our result suggests that immediate restructuring of former SOEs is important to realize fully the competitive benefits of opening local markets.J. Comp. Econom. , December 2000, 28(4), pp. 700–715. International Monetary Fund, 700 19th Street, NW, Washington, DC 20431.
Academic Adjustment Issues in a Malaysian Research University: The Case of Cambodian, Laotian, Burmese, and Vietnamese Postgraduate Students' Experiences

The Malaysian government aims to help the bottom billion countries, which are its neighbouring countries in the South East Asian region, for their human capital development through providing university postgraduate scholarship projects. Those countries include Cambodia, Laos PDR, Burma or Myanmar, and Vietnam (CLMV), which are favourite countries for its technical assistance. Due to the countries’ various educational systems, postgraduate students have experienced some academic difficulties during their studies and research in Malaysian universities. A qualitative research method is employed to investigate students’ living strategies, perception of academic success, and academic adjustment problems in a Malaysian university. Research samples were conducted conveniently selected from a total of 17 students made up of 6 Cambodian, 4 Laotian, 2 Myanmar, and 5 Vietnamese postgraduate students (47, 05% females and 52, 94% males) who have studied in the Universiti Sains Malaysia (USM) so called the Research University in the academic year 2012/2013, where they have attended the schools of educational studies, social science, and materials and mineral resource engineering. The result showed that the most difficult problem in term of academic adjustment which is English language difficulty in their new learning environment. In order to remedy such matters, they must strive to study hard, to improve English proficiency, and to make good relations with their academic staff, thesis supervisors, and other postgraduate students. In other words, social adjustment is considered as one of the important strategies that enable them to cope with the context of Malaysian culture. Based on the findings, the researchers provide recommendations to facilitate CLMV students to make better adjustments in a Malaysian research university and to achieve their academic endeavour.