Miracle-dz/UniFAR-FTUs huggingface dataset:
Control, dynamics and operation of a dual H-bridge current flow controller

In recent years, the demand for HVDC grids has greatly increased due to the integration of renewable energy, especially offshore wind energy. The current flow within the DC grid is passively determined by the resistance of the DC lines. In a complex DC grid, the current flow in each cable cannot be precisely controlled by adjusting the voltage set points of each converter and an overload may occur. In order to improve the efficiency of the branch utilization and the reliability of the grid, the current flow has to be rescheduled between DC nodes. This can be achieved by introducing a series current flow controller (CFC). This paper discusses the operation and control of a dual H-bridge CFC on a meshed connected DC grid. Two different strategies have been proposed to control the CFC, namely, master-slave control and single modulation control. A four-terminal DC grid has been modelled in Simulink/ SimPowerSystems to analyse the dynamic performance of the CFC under the proposed control strategies and a DC fault. The strategies have been compared in terms of system power losses. In addition, the operation and control of a reduced IGBT-based CFC is presented.
Quantitative evaluation of corneal epithelial oedema by confocal microscopy

Background: To develop a novel quantitative index for evaluation of corneal epithelial oedema, the pixel intensity of confocal microscopic images was measured derived from the basal cell layer (BCL) of the corneal epithelium in normal eyes, eyes before and after cataract surgery, and eyes affected by bullous keratopathy.
Bone Morphogenetic Proteins Regulate Interdigital Cell Death in the Avian Embryo

The embryonic limb bud provides an excellent model for analyzing the mechanisms that regulate programmed cell death during development. At the time of digit formation in the developing autopod, the undifferentiated distal mesodermal cells may undergo or chondrogenic differentiation or apoptosis depending whether they are incorporated into the future digital rays or into the interdigital spaces. Both chondrogenesis or apoptosis are induced by local BMPS. However, whereas the chondrogenic‐promoting activity of BMPs appears to be regulated through the BMPR‐ 1b receptor, the mechanism by which the BMPs execute the death program remains unknown. The BMP proapoptotic activity requires the expression of members of the msx family of closely related homeobox‐containing genes and is finally mediated by caspase activation, but the nature of the caspase(s) directly responsible for the cell death is also unknown. Finally, other growth factors present in the developing autopod at the stages of digit formation such as members of the FGF and TGFβ families modulate the ability of BMPs to induce cell death or chondrogenesis.
Review of sertraline in post-traumatic stress disorder

Sertraline (Zoloft™, Pfizer) is a selective serotonin re-uptake inhibitor (SSRI) with proven efficacy in the treatment of post-traumatic stress disorder (PTSD). PTSD is a serious, complex and often chronic mental illness that may follow exposure to a traumatic event. The high prevalence of traumatic events and PTSD in the general population and the resulting distress and dysfunction present a need for the systematic study of the efficacy and effectiveness of treatments for PTSD. Sertraline offers advantages over the older antidepressants, including demonstrated efficacy in PTSD, improved tolerability and low risk of lethality in overdose. Sertraline’s efficacy, favourable tolerability profile and relatively weak effect on the cytochrome P450 system are factors that contribute to make it a first-line agent of choice in the treatment of PTSD.
Antiparkinson therapeutic potencies correlate with their affinities at dopamine D2High receptors

To determine whether antiparkinson dopamine agonists preferentially act on the high‐affinity or the low‐affinity states of dopamine D1 and D2 receptors, the agonist potencies were obtained by competition against [3H]SCH23390 for D1High and D1Low, and against [3H]domperidone for D2High and D2Low. N‐propylnorapomorphine and cabergoline were the most potent at D2High, with dissociation constants of 0.18 and 0.36 nM, respectively. Other agonists had D2HighKi values of 0.52 nM for quinagolide, 0.6 nM for (+)PHNO, 0.9 for bromocriptine, 1.8 nM for apomorphine, 2.4 nM for pergolide, 3 nM for quinpirole, and 6.2 nM for lergotrile. There was a clear correlation between the Ki values at D2High and their therapeutic concentrations in the plasma water, as derived from the known concentrations after correction for the fraction bound to the human plasma proteins. The data suggest that D2High is the primary and common target for the antiparkinson action of dopamine agonists. Bromocriptine, cabergoline, lergotrile, pergolide, and pramipexole had no affinity for D1High, consistent with the clinical observations that the D2‐selective bromocriptine and pramipexole elicit low levels of dyskinesia. Synapse 61:1013–1018, 2007. © 2007 Wiley‐Liss, Inc.
Response of Biochemical Markers of Bone Turnover to Hormone Replacement Therapy: Impact of Biological Variability

Biochemical markers of bone turnover may be useful to monitor patients taking hormone replacement therapy (HRT). The aim of this study was to assess the utility of markers in monitoring HRT by comparing the response of a large panel of markers to HRT with their within subject variability. We measured the response of markers to transdermal estradiol in 11 postmenopausal women over 24 weeks. We measured the within subject variability of markers in 11 untreated healthy postmenopausal women over the same period. The mean decrease in markers of bone formation after 24 weeks treatment ranged from 19% for procollagen type I C‐terminal propeptide (PICP) to 40% for procollagen type I N‐terminal propeptide (PINP). The mean decrease in markers of bone resorption ranged from 10% for tartrate‐resistant acid phosphatase (TRAP) to 67% for C‐terminal cross‐linked telopeptide. The least significant change (LSC at p < 0.05), calculated from the within subject variability in the untreated group, was used to define response. LSC for osteocalcin was 21%, bone alkaline phosphatase 28%, PICP 24%, PINP 21%, type I collagen telopeptide 28%, TRAP 17%, urinary calcium 90%, hydroxyproline 75%, total deoxypyridinoline 47%, free pyridinoline 36%, free deoxypyridinoline 26%, N‐terminal cross‐linked telopeptide 70%, and C‐terminal cross‐linked telopeptide 132%. The greatest number of responders after 24 weeks of treatment were found using PINP and osteocalcin (9 each), and free deoxypyridinoline (8 each) and total deoxypyridinoline (7 each). Lumbar spine bone mineral density defined four patients as responders. The ability to detect a response differs between markers and is not dependent on the magnitude of response to therapy.
Web credibility research: a method for online experiments and early study results

Through iterative design and testing, we developed a procedure for conducting online experiments. Using this research method, we conducted two recent studies on Web credibility. The data from the first study suggest that Web banner ads reduce the perceived credibility of a Web page's content. The data from the second study show that attribution elements--in this case, author photographs--can also affect the credibility of Web content. This research method and our early results have implications for both HCI researchers and Web site designers.
Single-institutional experience with the surgical infection prevention project in intra-abdominal surgery.

BACKGROUND The incidence of surgical site infection (SSI) is becoming a key component of standard measures of quality of performance. We hypothesized that institutional implementation of a protocol targeting known risk factors would reduce the incidence of SSI associated with intra-abdominal surgery. METHODS Beginning in June 2004, a quality control initiative was implemented to prevent SSI in patients undergoing intra-abdominal surgical procedures at an academic medical center. This protocol included administration of the proper prophylactic antibiotic 0-60 minutes before incision, continued antibiotic administration for <or=24 hours, and maintenance of intraoperative normothermia (>or=36 degrees C), along with good glycemic control (goal<200 mg/dL 48 h postoperatively) in diabetic patients. Baseline data collected during the initial four months of protocol development (379 patients) were compared with data collected during the last four months of the 11-month study period (390 patients). RESULTS Compliance with antibiotic selection increased from 89 percent to 97 percent (p <or= 0.05). Compliance with timeliness of administration improved from 89 percent to 97 percent (p <or= 0.05), whereas cessation of perioperative antibiotics within 24 hours remained constant at 93 and 92 percent, respectively. The incidence of hypothermia fell from 15 percent to 10 percent (p = 0.27). The 30-day incidence of SSI improved from 9.2 percent to 5.6 percent (p = 0.07). CONCLUSION The implementation of a prevention protocol resulted in a substantial trend toward a reduction in the incidence of SSI. These data support the use of protocol implementation as a cost-effective method of reducing perioperative infectious morbidity associated with intra-abdominal surgery.
Evaluation of copper sulphate, formalin and peracetic acid in footbaths for the treatment of digital dermatitis in cattle

The efficacy of three non-antibiotic products (copper sulphate, formalin and peracetic acid) was compared with the efficacy of erythromycin, when the four substances were applied in footbaths for the treatment of cows with digital dermatitis. The cows were divided into four groups on the basis of their current housing and randomly allocated to one of the four treatments. Cattle allocated to the non-antibiotic treatments were footbathed daily for seven days, but the cattle treated with erythromycin were footbathed for two days only. Complete records were obtained for 252 lesions from 169 cows. There were significant reductions in the lesion scores of all four groups, but there was no significant effect of treatment and no significant interaction between treatment and time.
Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications

Chronic low-grade infection has been suggested to be associated with metabolic disorder such as diabetes. However, the molecular mechanism underlying this important association is largely unknown. The only clue established so far is that many subjects exhibit elevated levels of C-reactive protein as measured by highly sensitive assay. Here, we hypothesized that adipocyte–macrophage interaction plays a key role in amplifying such low grade infection to the level of influencing metabolic disorders. The presence of macrophages in abdominal adipose tissues was investigated by immunohistochemistry. To see whether molecules associated with acute phase protein, LPS signaling, and persistent recruitment of monocytes, are produced at higher amounts in adipocytes co-cultured with macrophages stimulated with low concentration of LPS (1 ng/ml), we measured serum amyloid A (SAA), LPS binding protein (LBP), soluble CD14 (sCD14), and RANTES levels in culture supernatant of co-cultures. Lastly, we investigated in vivo effect of low-grade LPS infusion on the production of these molecules using obese model mice. The macrophages were certainly identified in abdominal adipose tissues. Investigated molecules, especially LBP, SAA, and RANTES were produced at higher amounts in co-cultures stimulated with LPS compared with the cells without LPS. The ob/ob, and high-fat diet-induced obesity mice produced higher amounts of LBP, SAA, and RANTES one day after LPS infusion (1 ng/ml/g body weight) compared with ob/– and normal-fat fed control mice. Thus, adipocytes and infiltrated macrophages, and their interaction with low endotoxin stimulation appear to play an important role in amplifying and maintaining LPS-induced low-grade inflammation.
Mericitabine and ritonavir‐boosted danoprevir with or without ribavirin in treatment‐naive HCV genotype 1 patients: INFORM‐SVR study

Safety and tolerability of peginterferon‐based hepatitis C virus (HCV) infection therapy remains suboptimal, even when direct‐acting antiviral agents are added. This study assessed the efficacy, safety and tolerability of mericitabine combined with ritonavir‐boosted danoprevir (danoprevir/r) ± ribavirin for up to 24 weeks in treatment‐naïve HCV genotype (G)1 infected patients.
Human Nutrition and Metabolism Almonds and Almond Oil Have Similar Effects on Plasma Lipids and LDL Oxidation in Healthy Men and Women 1 , 2

Epidemiologic and clinical studies have shown that nut consumption is associated with favorable plasma lipid profiles and reduced cardiovascular risk. These effects may result from their high monounsaturated fat (MUFA) content but nuts contain constituents other than fatty acids that might be cardioprotective. We conducted a study to compare the effects of whole-almond vs. almond oil consumption on plasma lipids and LDL oxidation in healthy men and women. Using a randomized crossover trial design, 22 normolipemic men and women replaced half of their habitual fat ( 14% of 29% energy) with either whole almonds (WA) or almond oil (AO) for 6-wk periods. Compliance was ascertained by monitoring dietary intake via biweekly 5-d food records, return of empty almond product packages and weekly meetings with a registered dietitian. Fat replacement with either WA and AO resulted in a 54% increase in percentage of energy as MUFA with declines in both saturated fat and cholesterol intake and no significant changes in total energy, total or polyunsaturated fat intake. The effects of WA and AO on plasma lipids did not differ compared with baseline; plasma triglyceride, total and LDL cholesterol significantly decreased, 14, 4 and 6% respectively, whereas HDL cholesterol increased 6%. Neither treatment affected in vitro LDL oxidizability. We conclude that WA and AO do not differ in their beneficial effects on the plasma lipid variables measured and that this suggests that the favorable effect of almonds is mediated by components in the oil fraction of these nuts. J. Nutr. 132: 703–707, 2002.
Barriers to innovation adoption: a study of e-markets

– The purpose of this paper is to explore and expound the factors that impinge on the adoption and usage of industrial e‐markets. , – A review of the literature on e‐market adoption was followed by in‐depth interviews with senior managers in buyer, supplier, and e‐market organisations. Senior level executives (15) reported barriers and challenges to the adoption and usage of e‐markets operating in the aerospace and defence and higher education sectors. The interview data is transcribed, coded and analysed using the qualitative data analysis programme QSR N6. , – The paper found a number of barriers and challenges related risk perception, knowledge deficits, trust, firm size, and organisational readiness that moderate the adoption and usage of e‐markets in the sectors. , – There is unequal representation of buyer and supplier organisations between the two e‐market sectors. However, the case material enabled the research question to be answered and did not compromise the aims of the research. , – The case material presented in the paper can help academic researchers, managers, practitioners and other professionals better understand the barriers that impinge on e‐market adoption and find practical ways to mitigate those barriers. , – Recently, research on the barriers and challenges to e‐markets has been largely anecdotal and patchy with a paucity of studies noting factors that are likely to be conducive to e‐markets success. This study departs from such studies by offering empirical evidence of the factors in moderating the uptake of e‐markets.
The influence of governance form on the utility of corporate technological entrepreneurship activities —An empirical studies on Chinese bio-pharmaceutical industry

The article outlines and empirically tests a model of the moderating effect that governance form has on entrepreneurship-performance relationship. A sample of 65 high-tech new business venture was used to exam whether there is different effect between strategic alliance and mergers and acquisition on the relationship between corporate technological entrepreneurship and its financial performance. The result shows that alliance governance form positively moderates the relationship between corporate technological entrepreneurship and performance, but mergers and acquisitions governance form negatively moderates it.
Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism

Background:l-Arginine is a nutritional supplement that may be useful for promoting intestinal repair. Arginine is metabolised by the oxidative deiminase pathway to form nitric oxide (NO) and by the arginase pathway to yield ornithine and polyamines. Aims: To determine if arginine stimulates restitution via activation of NO synthesis and/or polyamine synthesis. Methods: We determined the effects of arginine on cultured intestinal cell migration, NO production, polyamine levels, and activation of focal adhesion kinase, a key mediator of cell migration. Results: Arginine increased the rate of cell migration in a dose dependent biphasic manner, and was additive with bovine serum concentrate (BSC). Arginine and an NO donor activated focal adhesion kinase (a tyrosine kinase which localises to cell matrix contacts and mediates β1 integrin signalling) after wounding. Arginine stimulated cell migration was dependent on focal adhesion kinase (FAK) signalling, as demonstrated using adenovirus mediated transfection with a kinase negative mutant of FAK. Arginine stimulated migration was dependent on NO production and was blocked by NO synthase inhibitors. Arginine dependent migration required synthesis of polyamines but elevating extracellular arginine concentration above 0.4 mM did not enhance cellular polyamine levels. Conclusions: These results showed that l-arginine stimulates cell migration through NO and FAK dependent pathways and that combination therapy with arginine and BSC may enhance intestinal restitution via separate and convergent pathways.
Social Support: A Mixed Blessing in Goal-Pursuit

Social support, in theory, should promote individual goal-pursuit. However, a growing number of studies shows that receiving support can undermine goal-pursuit. Addressing this paradox, we investigated a novel idea of the effects of how people think about their social support on their goal-pursuit. Four experiments showed that participants who were led to think abstractly (vs. concretely) about their social support showed higher intent to pursue their goal (Studies 1-3) and worked harder toward their goal (Study 4). The benefits of abstracting one’s social support occurred over a variety of personal goals, support types, and support-providers, indicating the generalizability and robustness of our findings. These results demonstrate that how people think about their social support influences goal-pursuit and suggest ways in which support-recipients can maximize their social support.
Changes in economic status of households associated with catastrophic health expenditures for cancer in South Korea.

BACKGROUND Cancer imposes significant economic challenges for individuals, families, and society. Households of cancer patients often experience income loss due to change in job status and/or excessive medical expenses. Thus, we examined whether changes in economic status for such households is affected by catastrophic health expenditures. MATERIALS AND METHODS We used the Korea Health Panel Survey (KHPS) Panel 1st-4th (2008- 2011 subjects) data and extracted records from 211 out of 5,332 households in the database for this study. To identify factors associated with catastrophic health expenditures and, in particular, to examine the relationship between change in economic status and catastrophic health expenditures, we conducted a generalized linear model analysis. RESULTS Among 211 households with cancer patients, 84 (39.8%) experienced catastrophic health expenditures, while 127 (40.2%) did not show evidence of catastrophic medical costs. If a change in economic status results from a change in job status for head of household (job loss), these households are more likely to incur catastrophic health expenditure than households who have not experienced a change in job status (odds ratios (ORs)=2.17, 2.63, respectively). A comparison between households with a newly-diagnosed patient versus households with patients having lived with cancer for one or two years, showed the longer patients had cancer, the more likely their households incurred catastrophic medical costs (OR=1.78, 1.36, respectively). CONCLUSIONS Change in economic status of households in which the cancer patient was the head of household was associated with a greater likelihood that the household would incur catastrophic health costs. It is imperative that the Korean government connect health and labor policies in order to develop economic programs to assist households with cancer patients.
Randomized comparison of enoxaparin with unfractionated heparin for the prevention of venous thromboembolism in medical patients with heart failure or severe respiratory disease.

BACKGROUND We compared the efficacy and safety of the low-molecular weight heparin enoxaparin with unfractionated heparin (UFH) for the prevention of venous thromboembolic disease in patients with heart failure or severe respiratory disease. METHODS This was a multicenter, controlled, randomized, open study in which patients received either enoxaparin (40 mg once daily) or UFH (5000 IU 3 times daily) for 10 +/- 2 days in 64 medical departments in Germany. Patients were stratified and enrolled according to their underlying disease: severe respiratory disease or heart failure. The primary efficacy parameter was a thromboembolic event up to 1 day after the treatment period. RESULTS Of the 665 patients enrolled, 451 patients were able to be evaluated in the primary efficacy analysis. The incidence of thromboembolic events was 8.4% with enoxaparin and 10.4% with UFH. Enoxaparin was at least as effective as UFH, with a 1-sided equivalence region of -4% (90% CI -2.5-6.5, P =.015). Enoxaparin was associated with fewer deaths, less bleeding, and significantly fewer adverse events (45.8% vs 53.8%, P =.044). CONCLUSIONS Enoxaparin is at least as effective as UFH in the prevention of thromboembolic events in patients with heart failure or severe respiratory disease. Its beneficial safety profile and once-daily administration is advantageous for inpatient and outpatient use.
Neural coding and perceptual detection in the primate somatosensory thalamus

The contribution of the sensory thalamus to perception and decision making is not well understood. We addressed this problem by recording single neurons in the ventral posterior lateral (VPL) nucleus of the somatosensory thalamus while trained monkeys judged the presence or absence of a vibrotactile stimulus of variable amplitude applied to the skin of a fingertip. We found that neurons in the VPL nucleus modulated their firing rate as a function of stimulus amplitude, and that such modulations accounted for the monkeys’ overall psychophysical performance. These neural responses did not predict the animals' decision reports in individual trials, however. Moreover, the sensitivity to changes in stimulus amplitude was similar when the monkeys’ performed the detection task and when they were not required to report stimulus detection. These results suggest that the primate somatosensory thalamus likely provides a reliable neural representation of the sensory input to the cerebral cortex, where sensory information is transformed and combined with other cognitive components associated with behavioral performance.