Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of acute head injury in an emergency department population using sport concussion assessment tool – 3rd edition

ABSTRACT Sport Concussion Assessment Tool version 3 (SCAT-3) is one of the most widely researched concussion assessment tools in athletes. Here normative data for SCAT3 in nonathletes are presented. The SCAT3 was administered to 98 nonathlete healthy controls, as well as 118 participants with head-injury and 46 participants with other body trauma (OI) presenting to the ED. Reference values were derived and classifier functions were built to assess the accuracy of SCAT3. The control population had a mean of 2.30 (SD = 3.62) symptoms, 4.38 (SD = 8.73) symptom severity score (SSS), and 26.02 (SD = 2.52) standardized assessment of concussion score (SAC). Participants were more likely to be diagnosed with a concussion (from among healthy controls) if the SSS > 7; or SSS ≤ 7 and SAC ≤22 (sensitivity = 96%, specificity = 77%). Identification of head injury patients from among both, healthy controls and body trauma was possible using rule SSS > 7 and headache or pressure in head present, or SSS ≤ 7 and SAC ≤ 22 (sensitivity = 87%, specificity = 80%). In this current study, the SCAT-3 provided high sensitivity to discriminate acute symptoms of TBI in the ED setting. Individuals with a SSS > 7 and headache or pressure in head, or SSS ≤ 7 but with a SAC ≤ 22 within 48-hours of an injury should undergo further testing.
[Symptomatic treatment of dyspnoea in patients receiving palliative care: nasal delivery of oxygen compared with opioid administration].

BACKGROUND AND OBJECTIVE Dyspnoea frequently occurs in patients with advanced tumor disease receiving palliative care (prevalence > 50). Aim of the study was to assess, in dyspneic patients in palliative care, the efficacy of opioids in treating their dyspnoea and to determine whether or not nasal administration of oxygen previous to opioid administration would decrease the severity of dyspnoea. PATIENTS AND METHODS In a prospective, non-randomised study 25 patients with cancer who had been admitted to our palliative care unit were investigated (aged 64.5 +/- 15.1 [40-90] years; 11 males [44 %]. 13 patients reported severe and 12 moderate dyspnoea. For symptomatic treatment of dyspnoea, 12 patients received morphine and 13 patients hydromorphine. The severity of of dyspnoea was rated according to a numeric scale (NRS 0-10). Recorded and compared was severity of dyspnoea at admission before any oxygen had been administered, after 30 minutes of nasal oxygen, and 30, 60, 90 and 120 minutes after the first administration of opioid without nasal oxygen. RESULTS Whereas there was no change in the severity of dyspnoea during nasal oxygen administration, mean respiratory rate (f) 30 minutes after the first opioid application had significantly decreased. The intensity of dyspnoea had significantly diminished 90 minutes after the first opioid application. CONCLUSION During nasal oxygen administration the severity of dyspnoea, as measured by use of NRS had not decreased, whereas it had significantly decreased after the first opioid administration.
Les narrations quantifiées. Une méthode mixte pour étudier des processus sociaux

Les narrations quantifiees. Une methode mixte pour etudier des processus sociaux 1 Terrains et Travaux, n°19, pp. 161-182 (ISSN 1627-9506) Resume La methode presentee dans cet article est concue pour des situations ou l'on souhaite mettre en evidence des dynamiques sociales. Ce sont aussi des situations ou l'on ne dispose pas de sources de donnees existantes qui puissent etre formalisees, et donc ou il faut en construire de nouvelles ; et ou par ailleurs, on juge que les methodes de type questionnaire ne sont pas adaptees. La methode prend pour objet des processus au cours desquels peuvent evoluer des personnes, des organisations (ou d'autres collectifs), des relations sociales et des ressources, sans privilegier necessairement le niveau des parcours individuels ou celui des histoires d'organisations. Cette methode s'inspire a la fois des recits de pratiques, de l'histoire orale et d'une approche des reseaux sociaux qui se centre sur les chaines de relations activees dans l'acces a certaines ressources. Elle consiste pour l'essentiel a realiser des entretiens croises portant sur le meme processus, a rediger une synthese des temoignages et a coder certains aspects des informations obtenues.
Miz1 Controls Schwann Cell Proliferation via H3K36me2 Demethylase Kdm8 to Prevent Peripheral Nerve Demyelination

Schwann cell differentiation and myelination depends on chromatin remodeling, histone acetylation, and methylation, which all affect Schwann cell proliferation. We previously reported that the deletion of the POZ (POxvirus and Zinc finger) domain of the transcription factor Miz1 (Myc-interacting zinc finger protein; encoded by Zbtb17) in mouse Schwann cells (Miz1ΔPOZ) causes a neuropathy at 90 d after birth [postnatal day (P) 90], with a subsequent spontaneous regeneration. Here we show that RNA sequencing from Miz1ΔPOZ and control animals at P30 revealed a set of upregulated genes with a strong correlation to cell-cycle regulation. Consistently, a subset of Schwann cells did not exit the cell cycle as observed in control animals and the growth fraction increased over time. From the RNAseq gene list, two direct Miz1 target genes were identified, one of which encodes the histone H3K36me2 demethylase Kdm8. We show that the expression of Kdm8 is repressed by Miz1 and that its release in Miz1ΔPOZ cells induces a decrease of H3K36me2, especially in deregulated cell-cycle-related genes. The linkage between elevated Kdm8 expression, hypomethylation of H3K36 at cell-cycle-relevant genes, and the subsequent re-entering of adult Schwann cells into the cell cycle suggests that the release of Kdm8 repression in the absence of a functional Miz1 is a central issue in the development of the Miz1ΔPOZ phenotype. SIGNIFICANCE STATEMENT The deletion of the Miz1 (Myc-interacting zinc finger protein 1) POZ (POxvirus and Zinc finger) domain in Schwann cells causes a neuropathy. Here we report sustained Schwann cell proliferation caused by an increased expression of the direct Miz1 target gene Kdm8, encoding a H3K36me2 demethylase. Hence, the demethylation of H3K36 is linked to the pathogenesis of a neuropathy.
In Vitro Reconstitution of Centmmm and Function : The Central Rde of y = Tubuiin

The centrosome nucleates microtubule polymerization, affecting mkrotubule number, polarity, and structure. We use an in vitro system based on extmcts of Xenopus eggs to examine the role of y-tubulin in centrosome assembly and function. y-Tubuiin is present in the cytoplasm of frog eggs and vertebrate somatic cells in a large 255 complex. The egg extracts assemble centroaomes around sperm centrloies. Formation of a centrosome in the extract requires both the y-tubuiln complex and ATP and can take place in the absence of microtubulea. y-Tubulin is not present on the sperm prior to incubation in extract, but is recruited from the cytoplasm during centroaome assembly. The +Mlin complex also binds to mkrotubuies, likely the minus end, indepemknt of the centrosome. These reeults suggest that y-tubulin is an essential component of the link between the centroeome and the microtubule, probably playing a direct role in microtubule nucleation.
Renal Metastases of Gestational Trophoblastic Disease: A Report of Eight Cases

Between 1968–1984, eight women with renal metastases of gestational trophoblastic disease were treated at the Southeastern Regional Trophoblastic Disease Center. Two (1.3%) of 154 patients referred for primary therapy and six (14%) of 42 patients referred for secondary therapy of metastatic gestational trophoblastic disease had renal metastases. All eight had coexistent pulmonary metastases. Four had central nervous system and other systemic metastases. All had high-risk metastatic gestational trophoblastic disease by assessment of individual risk factors and analysis of a prognostic index score. Three women with limited systemic tumor burden are alive after receiving multiagent chemotherapy and nephrectomy.
Antimalarial Activity of Tanzanian Plants and their Active Constituents: The Genus Uvaria 1

Uvaria species: U. dependens, U. faulknerae, U. kirkii, U. leptocladon, U. lucida ssp. lucida, Uvaria U. scheffleri U. tanzaniae in vitro Plasmodium falciparum U. lucida lucida Uvaria U. scheffleri
What do we really know about the signalling role of plumage colour in blue tits? A case study of impediments to progress in evolutionary biology

Evolutionary biologists seek to explain the origin and maintenance of phenotypes, and a substantial portion of this research is accomplished by thorough study of individual species. For instance, many researchers study individual species to understand evolution of ornamental traits which appear to be products of sexual selection. I explored our understanding of sexual ornaments in a well‐studied vertebrate species that may serve as a case study for research programs in evolutionary biology. I attempted to located all published papers examining plumage colour and variables related to sexual selection hypotheses in a common European songbird, the blue tit (Cyanistes caeruleus). Researchers have estimated over 1200 statistical relationships with plumage colour of blue tits in 52 studies. However, of the approximately 1000 main‐effect relationships from the 48 studies that are candidates for inclusion in this meta‐analysis, more than 400 were reported without details of strength and direction. Circumstantial evidence suggests that an unknown number of other estimated effects remain unpublished. Missing information is a substantial barrier to interpretation of these papers and to meta‐analytic synthesis. Examination and analysis of funnel plots indicated that unpublished effects may be a biased sample of all effects, especially for comparisons of plumage colour to age and individual quality, and possibly also to measures of mate choice. Further, type I error was likely elevated by the large number of statistical comparisons evaluated, the frequent use of iterative model‐building procedures, and a willingness to interpret a wide variety of results as support for a hypothesis. Type I errors were made more problematic because blue tit plumage researchers only rarely have attempted to replicate important findings in their own work or that of others. Replication is essential to drawing robust scientific conclusions, especially in probabilistic systems with moderate to weak effects or a likelihood of bias. Last, researchers studying blue tit plumage have often developed ad hoc explanations for deviations of results from their predictions. Revising hypotheses in light of data is appropriate, but these revised hypotheses were rarely tested with new data. The only highly robust conclusion supported by meta‐analysis is that male blue tits have plumage that reflects more light in the ultraviolet and yellow wavelengths than the plumage of females. Various other effects, including condition‐dependence of plumage colour expression and a tendency for females to adjust the sex ratio of their offspring in response to male colour, remain uncertain. These obstacles to progress in the blue tit plumage literature are likely common in evolutionary biology, and so I recommend changes to incentive structures which may improve progress towards scientific understanding in this discipline.
SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule disrupting agents

SEPT9 is a mammalian septin family member. There is growing evidence that SEPT9 plays a role in cancer. The protein product, SEPT9_V1, associates with microtubules and interacts with hypoxia-inducible factor (HIF)-1α, the regulated subunit of the key transcription factor HIF-1. HIF-1 transcriptional activity is thoroughly dependent on intact microtubules. We tested the hypothesis that SEPT9_V1 confers resistance to microtubule-mediated HIF-1 inhibitors. SEPT9_V1 protein expression was strongly correlated with susceptibility of a wide range of cancer cells to 2-methoxyestradiol and paclitaxel. Our results revealed that SEPT9_V1 could serve as a biomarker for therapeutic resistance to microtubule disrupting agents
Layered space–time block code for hybrid satellite–terrestrial broadcasting systems

Multiple‐input multiple‐output (MIMO) is a topic of high interest for the next generation of broadcasting systems. Even if they have begun to be proposed for the second generation of terrestrial digital TV, there are still gaps in the deployment of MIMO schemes in single‐frequency networks. This deployment becomes more critical when a hybrid satellite–terrestrial transmission is adopted because of the different aspects of the respective transmission links. In this paper, we propose to apply a layered space–time block code (LSTBC) for MIMO schemes in this hybrid transmission for next‐generation handheld (NGH) systems. The contribution of this paper is multi‐fold. First, we detail the land mobile satellite channel specifications describing the satellite link. Then, we propose to apply a MIMO scheme between the antennas of the satellite site and the terrestrial site. Then, we introduce the LSTBC scheme for NGH broadcasting systems. The proposed code is based on a layered construction designed to be efficient in shadowing regions. This efficiency is verified in a line‐of‐sight situation but also in low, moderate and deep shadow situations. The LSTBC scheme is then a very promising candidate for NGH systems with MIMO transmission. Copyright © 2012 John Wiley & Sons, Ltd.
An Imidazoline 2 Receptor Ligand Relaxes Mouse Aorta via Off-Target Mechanisms Resistant to Aging

Imidazoline receptors (IR) are classified into three receptor subtypes (I1R, I2R, and I3R) and previous studies showed that regulation of I2R signaling has neuroprotective potential. In order to know if I2R has a role in modulating vascular tone in health and disease, we evaluated the putative vasoactive effects of two recently synthesized I2R ligands, diethyl (1RS,3aSR,6aSR)-5-(3-chloro-4-fluorophenyl)-4,6-dioxo-1-phenyl-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrrole -1-phosphonate (B06) and diethyl [(1-(3-chloro-4-fluorobenzyl)-5,5-dimethyl-4-phenyl-4,5-dihydro-1H-imidazol-4-yl]phosphonate] (MCR5). Thoracic aortas from Oncins France 1 (3- to 4-months-old) and C57BL/6 (3- to 4- and 16- to 17-months-old mice) were mounted in tissue baths to measure isometric tension. In young mice of both strains, MCR5 induced greater relaxations than either B06 or the high-affinity I2R selective ligand 2-(2-benzofuranyl)-2-imidazoline (2-BFI), which evoked marginal responses. MCR5 relaxations were independent of I2R, as IR ligands did not significantly affect them, involved activation of smooth muscle KATP channels and inhibition of L-type voltage-gated Ca2+ channels, and were only slightly modulated by endothelium-derived nitric oxide (negatively) and prostacyclin (positively). Notably, despite the presence of endothelial dysfunction in old mice, MCR5 relaxations were preserved. In conclusion, the present study provides evidence against a functional contribution of I2R in the modulation of vascular tone in the mouse aorta. Moreover, the I2R ligand MCR5 is an endothelium-independent vasodilator that acts largely via I2R-independent pathways and is resistant to aging. We propose MCR5 as a candidate drug for the management of vascular disease in the elderly.
Hypoalbuminemia, oliguria and peripheral cyanosis in an infant with severe atopic dermatitis

A six‐month old male infant with severe atopic dermatitis was admitted with hypoalbuminemia, oliguria and cyanosis of the extremitie. s. There was marked edema and generalized eczema with foul, yellowish exudates. The patient's major clinical manifestations were attributed to the loss of albumin through the skin. Although atopic dermatitis is a common disease in children, here we want to show that systemic disturbances may arise from such condition, describe the total care given the patient, and emphasize the wholistic approach in managing cases of severe atopic dermatitis, intensive treatment was instituted and the patient was discharged after three weeks and remained in a stable condition.
Phenotypic Characterization of Idiopathic Epilepsy in Border Collies

The prevalence of idiopathic epilepsy (IE) within the Border Collie (BC) dog breed is high. The aim of this retrospective study was to describe the phenotype of BCs with IE and assess correlations between phenotypic variables and owner-provided quality-of-life (QoL) scores. Data of BCs diagnosed with IE during the period of five consecutive years were retrospectively analyzed. All the dogs were presented at least once to a veterinary neurology specialist at one of three veterinary referral hospitals and most were under the continued medical care of that specialist. Owners were requested to complete a standardized online questionnaire including quality-of-life (QoL) scoring questions. Data of a total of 116 BC dogs were included for analysis. The median age at onset of the first epileptic seizure (ES) was 33.5 months (6–188). A total of 34/86 (40%) of medically treated dogs received 1 antiseizure medication (ASM) and 52/86 (60%) received ≥2 ASMs. Phenobarbital was the most commonly employed ASM, used in 70/86 of treated dogs (81%). Four or more side effects were observed in 20/86 (23%) of treated dogs. Age at onset of first ES was significantly lower for dogs having experienced cluster seizures (CSs), status epilepticus (SE), or both (median 27 months) vs. dogs that had not experienced CS or SE (median 43 months). The QoL of BC with IE was scored with a median score of 7 out of 10. Owners scored their dog's QoL to have declined by a median of 30% during the course of life with IE with 39% (37/95) of owners scoring their dog's QoL to have declined by ≥50%. This study confirms the association of age at onset of first ES with the severity of epilepsy (e.g., presence of CS and/or SE) and further characterizes the phenotype of IE in BC dogs. QoL of BC can be heavily impacted by IE.
Primary cerebral ganglioneurocytoma in an adult

A case of an unusual cerebral neuronal tumor in a 37‐year‐old woman is described. A clearly marginated tumor, which was found to occupy the septum pellucidum, genu of the corpus callosum, and right frontal lobe, was composed of ganglionic and small round cells. These two populations of neoplastic cells were both interpreted as being in the advanced stages of neuronal maturation, and the authors thus designated this tumor as a “ganglioneurocytoma. ” Related nosologic problems on central neuronal tumors and their possible histogenesis are also discussed.
A Possible Relationship Between Polymorphisms of Glutathione S-Transferase M1, P1 and T1 Genes and Rheumatoid Arthritis in Zahedan, Southeast Iran

Hastalar ve yontemler: Bu olgu kontrollu calismaya Iranli 100 RA hastasi (88 kadin, 12 erkek; ort. yas 44.1±13.2 yil; dagilim 17-75 yil) ve 100 saglikli birey (68 kadin ve 32 erkek, ort. yas 45.7±9.6 yil; dagilim 23-70 yil) dahil edildi. GSTP1 polimorfizm tetra amplifikasyona direncli mutasyon sistem polimeraz zincir reaksiyonu (Tetra-ARMS-PCR) ile belirlenirken, GSTM1 ve GSTT1 polimorfizmleri multipleks PCR kullanilarak analiz edildi.
An Epidemiological Study of Tics

Abstract: We devised a questionnaire for estimation of each tic, and used a two‐step investigation procedure, first by a parent questionnaire with 1,218 responses and second by a confirmatory telephone interview for 197 positive responses. The average estimated values were 11.3% for boys and 5.2% for girls. The prevalences were–blinking: 4.2%, head‐jerking: 1.6%, shrugging: 1.2%, mouth‐twitching: 0.6%, face‐distortion: 0.5%, mouth‐opening: 0%, throat‐clearing: 2.7%, sniffing: 0.6%, and vocalization: 0.2%. According to the criteria in DSM‐III‐R, 5.1% of 1,218 had TTD, 2.2% had CMVTD, and 0.5% had Tourette disorder.
The Human Dopamine Transporter Forms a Tetramer in the Plasma Membrane

Using cysteine cross-linking, we demonstrated previously that the dopamine transporter (DAT) is at least a homodimer, with the extracellular end of transmembrane segment (TM) 6 at a symmetrical dimer interface. We have now explored the possibility that DAT exists as a higher order oligomer in the plasma membrane. Cysteine cross-linking of wild type DAT resulted in bands on SDS-PAGE consistent with dimer, trimer, and tetramer, suggesting that DAT forms a tetramer in the plasma membrane. A cysteine-depleted DAT (CD-DAT) into which only Cys243 or Cys306 was reintroduced was cross-linked to dimer, suggesting that these endogenous cysteines in TM4 and TM6, respectively, were cross-linked at a symmetrical dimer interface. Reintroduction of both Cys243 and Cys306 into CD-DAT led to a pattern of cross-linking indistinguishable from that of wild type, with dimer, trimer, and tetramer bands. This indicated that the TM4 interface and the TM6 interface are distinct and further suggested that DAT may exist in the plasma membrane as a dimer of dimers, with two symmetrical homodimer interfaces. The cocaine analog MFZ 2–12 and other DAT inhibitors, including benztropine and mazindol, protected Cys243 against cross-linking. In contrast, two substrates of DAT, dopamine and tyramine, did not significantly impact cross-linking. We propose that the impairment of cross-linking produced by the inhibitors results from a conformational change at the TM4 interface, further demonstrating that these compounds are not neutral blockers but by themselves have effects on the structure of the transporter.
Changes in Microbial Community Composition and Function during a Polyaromatic Hydrocarbon Phytoremediation Field Trial

ABSTRACT The purpose of this study was to investigate the mechanism by which phytoremediation systems promote hydrocarbon degradation in soil. The composition and degradation capacity of the bulk soil microbial community during the phytoremediation of soil contaminated with aged hydrocarbons was assessed. In the bulk soil, the level of catabolic genes involved in hydrocarbon degradation (ndoB, alkB, and xylE) as well as the mineralization of hexadecane and phenanthrene was higher in planted treatment cells than in treatment cells with no plants. There was no detectable shift in the 16S ribosomal DNA (rDNA) composition of the bulk soil community between treatments, but there were plant-specific and -selective effects on specific catabolic gene prevalence. Tall Fescue (Festuca arundinacea) increased the prevalence of ndoB, alkB, and xylE as well as naphthalene mineralization in rhizosphere soil compared to that in bulk soil. In contrast, Rose Clover (Trifolium hirtum) decreased catabolic gene prevalence and naphthalene mineralization in rhizosphere soil. The results demonstrated that phytoremediation systems increase the catabolic potential of rhizosphere soil by altering the functional composition of the microbial community. This change in composition was not detectable by 16S rDNA but was linked to specific functional genotypes with relevance to petroleum hydrocarbon degradation.
The Influence of Consumers Perception of Green Products on Green Purchase Intention

Green consumerism has increasingly received attention since the increased level of consumer awareness towards green products. Therefore, the aim of this paper had been to examine the influence of consumer perception of green products on green purchase intention. In this study, perception of green products was conceptualized as a multidimensional variable comprised of green corporate perception, eco-label, green advertising, green packaging, and green product value. By using a survey, a total of 159 questionnaires from respondents aged above 18 in Sabah were collected. The results demonstrated that within consumer perception; green corporate perception, eco-label, and green product value had positive significant influences on green purchase intention. The findings also revealed that eco-label and green product value made the largest contribution in influencing green purchase intention among consumers. In contrast, both green advertising and green packaging had no significant impact on consumer intention to purchase green products.