Miracle-dz/UniFAR-FTUs huggingface dataset:
In vitro Evaluation of Acidified Toothpastes with Low Fluoride Content

Fluoride toothpastes are a risk factor for the development of dental fluorosis. Products with low fluoride content offer a higher security, but their effectiveness must be proven. The aim of this in vitro study was to compare two acidified toothpastes with low fluoride concentration (412 and 550 µg F/g) with neutral toothpastes. Bovine enamel blocks were selected by surface microhardness (SMH) and randomized to twelve groups of 13, according to the fluoride concentration in toothpaste (placebo, 275, 412, 550 or 1,100 µg F/g) and pH (7.0 or 5.5). Two commercially available toothpastes were also studied: a 1,100-µg F/g, pH 7.0 paste (positive control) and a children’s paste (500 µg F/g, pH 7.0). The blocks were subjected to pH cycling for 7 days. The toothpaste treatment was done twice daily. Surface and cross-sectional microhardnesses were assessed to calculate the percentage change of SMH (%SMH) and the mineral loss (ΔZ). The amount of fluoride, calcium and phosphorus in the solutions after the pH cycling was also analyzed. Compared to neutral toothpastes, the acidified toothpastes reduced the %SMH in all F concentrations. Higher F and lower Ca and P concentrations were found in solutions for the acidified toothpastes. Regarding ΔZ, only the positive control, 1,100-µg F/g (acidified and neutral) groups were not statistically different. The acidified toothpastes showed a dose-response relationship with all variables. For the low-fluoride toothpastes evaluated, only the 550-µg F/g acidified paste had the same anticariogenic action as the 1,100-µg F/g neutral paste.
Automated classification of EEG signals for predicting students' cognitive state during learning

For distance learning applications, inferring the cognitive states of students, particularly, their concentration and comprehension levels during instruction, is important to assess their learning efficacy. In this paper, we investigated the feasibility of using EEG recordings generated from an off-the-shelf, wearable device to automatically classify the cognitive states of students as they were asked to perform a series of reading and question answering tasks. We showed that the EEG data can effectively predict whether a student is attentive or distracted as well as the student's reading speed, which is an important measure of reading fluency. However, the EEG signals alone are insufficient to predict how well the students can correctly answer questions related to the reading materials as there were other confounding factors, such as the students' background knowledge, that must be taken into consideration. We also showed that the accuracy in predicting the different cognitive states depends on the choice of classifier used (global, local, or multi-task learning). For example, the concentration level of a student can be accurately predicted using a local model whereas a global model that incorporates side information about the student's background knowledge is more effective at predicting whether the student will correctly answer questions about the materials they read.
[Risk factors for osteoporosis in postmenopausal women from southeast Brazilian].

PURPOSE To evaluate bone mineral density (BMD) and their risk factors associated with postmenopausal osteoporosis. METHODS A cross-sectional clinical study was performed on 431 women (aged 40-75 years). INCLUSION CRITERIA amenorrhea > 12 months and age > 45 years or, bilateral oophorectomy > 40 years with BMD values (T-score of lumbar spine/femur neck) by DXA of the last 12 months. Risk factors evaluated: age, age and time of menopause, smoking, physical activity (30 min/5 times/week), rheumatoid arthritis (RA), use of corticotherapy and hormone therapy (HT), previous fracture, maternal hip fracture and body mass index (BMI = weight/height²). The χ2 test and the logistic regression method (Odds Ratio--OR) were used to determine osteoporosis risk. RESULTS According to WHO criteria, 106 (24.6%) women showed osteoporosis (T-score < -2.5 DP), 188 (43.6%) osteopenia (-1.0/-2.4 DP), and 137 (31.8%) were normal (> -1.0 DP). Osteoporosis was detected in 12% of women aged 40-49 years, in 21.8% of women aged 50-59 years and in 45.7% of women aged > 60 years (p < 0.001). Osteoporosis occurred in 11.8% of women with a menopause period < 5 years, in 29.4% with a menopause period from 6 to 10 years, and in 41% of women with a menopause period > 10 years (p < 0.001). Of the women with early menopause, 80% showed osteopenia/osteoporosis (p = 0.03), and of those with BMI < 20 kg/m², 50% were osteoporotic (p < 0.001). The risk for osteoporosis detection increased with age (OR = 1.1; CI 95% = 1.0-1.1), time of menopause (OR = 1.1; CI 95% = 1.0-1.1), smoking (OR = 1.9; CI 95% = 1.2-3.2), RA (OR = 3.6; CI 95% = 1.3-9.6) and maternal fracture history (OR = 2.1; CI 95% = 1.1-3.0) (p < 0.05). In contrast, HT use (OR = 0.3; 95% CI = 0.2-0.6) and high BMI (OR = 0.9; 95% CI = 0.8-0.9) reduced the risk (p < 0.05). CONCLUSION In postmenopausal women, age, time of menopause, smoking and maternal history of fracture were clinical indicators of risk for osteoporosis, whereas HT use and high BMI proved to be protective factors.
Idiopathic Granulomatous Angiitis of the Central Nervous System: Diagnostic Challenges

• Objective. —Granulomatous angiitis of the central nervous system (CNS) is a rare cause of vasculitis involving the brain and spinal cord and is included in lists of disorders causing strokes. To determine the frequency of strokes (eg, sudden onset of focal symptoms) as a presenting complication and to determine the sensitivity of angiography and other technologies in detecting vasculitis in histologically proved cases of idiopathic granulomatous angiitis of the CNS (IGANS), we reviewed the published literature. Data Sources. —A biopsy-proved case of IGANS in a patient presenting without strokes and with a normal angiogram is reported. Additional cases of pathologically proved IGANS where results of angiography or other neuroimaging procedures were available were found by search of MEDLINE and bibliographies of pertinent articles and books. Data Extraction. —We compared our case with 39 reported cases of histologically proved granulomatous angiitis of the CNS not associated with Hodgkin's disease, herpes zoster, sarcoidosis, or other proximate cause. We included only those cases that had been evaluated with angiography or other neuroimaging techniques before death or biopsy. Data Synthesis. —Analysis of these cases shows that strokes as presenting complications are rare in IGANS. Most patients present with a diffuse encephalopathy and, when focal symptoms develop, they tend to develop gradually. Including our case, 56% of 41 angiograms performed in 31 reported patients with histologically proved IGANS were abnormal, but only 27% were diagnostic for vasculitis. Conclusions. —We conclude that stroke is uncommon as a presenting complaint in IGANS and angiography is insensitive as a screening test for these patients.
Sex dependence of brain size and shape in bipolar disorder: an exploratory study.

OBJECTIVES Anomalies of asymmetry and sex differences in brain structure have frequently been described in schizophrenic illnesses but have seldom been explored in bipolar disorder. METHODS We measured volumes of the left and right frontal, temporal, parietal, and occipital lobes and computed the magnitude of brain torque (i.e., rightward frontal and leftward occipital asymmetry) for 49 patients with bipolar disorder and 47 healthy controls and performed an exploratory analysis of sex differences in patients and controls. RESULTS Patients had significantly greater cerebrospinal fluid volume than controls, but no difference in total brain volume. There were no main effects of diagnosis in gray matter lobe volume or brain torque, but when analyses were performed separately for male and female subjects, significant sex-by-diagnosis interactions were found in the volume of the left frontal, left temporal, right parietal, and right occipital lobes, such that male patients with bipolar disorder tend toward larger, more symmetric brains than male controls, whereas female patients tend toward smaller, more asymmetric brains than female controls. CONCLUSION The lateralised nature of these interactions was such that the normal sex difference in volume was significantly accentuated, whilst the normal sex difference in asymmetry tended to be diminished in patients with bipolar disorder. We conclude that bipolar disorder in part reflects an interaction between brain growth and sex along the anterior-posterior axis of the human brain.
Policy-specific effects of transgovernmental cooperation: a statistical assessment across the EU’s post-Soviet neighbours

ABSTRACT Can transgovernmental networks facilitate democratization in third countries? If so, to what extent and under what conditions can they impact states’ behaviour? Earlier works demonstrate that transgovernmental professional networks set by the European Union can shape attitudes of officials towards democracy in third countries. However, it remains unclear whether they change their behaviour, too; nor do we have an understanding of how long these changes last. Using the time-series cross-sectional analysis and focusing on two policy fields, human rights and public administration in the former Soviet republics, this article demonstrates that transgovernmental networks can stimulate improvements in domestic practices in third countries. At the same time, the results hint that their effects are policy-specific and rather short-lived.
Psychological Adjustment to Conjugal Bereavement: Do Social Networks Aid Coping following Spousal Death?

This research sought to investigate the role of social networks in coping and adjustment to spousal bereavement. A total of 198 Xhosa-speaking participants, drawn from the rural areas of the Eastern Cape Province, South Africa, took part in the study. Quantitative data analyses revealed significant correlations between perceived social support on Social Support Appraisals scale and the anxiety scores on the Beck Depression Inventory-Second Edition and the problem-solving coping strategy scale on the Coping Strategy Indicator. Regression analyses revealed that depression contributed to increased social support appraisals, while anxiety was a significant negative predictor of the participants' experience of perceived social support. The authors highlight the need for bereavement intervention programs in the rural areas to be geared toward psycho-educating the conjugally bereaved individuals, within the socio-cultural framework, to continuously evaluate their support structures and strengthen ties with social networks that render support, instrumental assistance, and advice in times of need.
Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon.

AIMS We have previously demonstrated links between clinicopathological findings and phenotypes using several gastric and intestinal phenotypic markers in stomach and pancreatic cancers. However, the clinicopathological significance of the phenotype and Cdx2 expression has hitherto remained unclear in colorectal carcinogenesis. METHODS AND RESULTS We examined the correlation between gastric and intestinal phenotypic expression in 91 primary early carcinomas of the colon. MUC2 expression demonstrated a significant decrease from tubular/tubulovillous adenomas with moderate atypia, through intramucosal carcinomas, to cancers with submucosal invasion (P<0.0001). Intramucosal de novo carcinomas (flat type carcinomas without adenomatous components) exhibited a greater decrease of MUC2 than intramucosal lesions with adenomatous components. Expression of MUC5AC also decreased significantly with progression according to the tubular/tubulovillous adenoma-carcinoma sequence, carcinomas with villous adenomatous components having a higher level compared with their tubular adenomatous counterparts, suggesting differences in the pathway of malignant transformation. Cdx2 nuclear expression was maintained in all of the adenomas and early carcinomas examined. CONCLUSIONS Our data suggest that the reduction of MUC2 expression may be associated with the occurrence and progression of colorectal carcinomas in both adenoma-carcinoma sequence pathway and de novo carcinogenesis. Tumor-suppressive effects of Cdx2 may be preserved during early stages of colorectal carcinogenesis.
Socioeconomic Disparities in Age of Initiation and Ever Tobacco Smoking: Findings from Romania.

AIM Smoking initiation is considered the fundamental behaviour that determines the future health burden of tobacco smoking in a society. The aim of the study was to evaluate the socio-demographic factors associated with initiation of regular smoking among adults. METHODS The data source was the 2011 Global Adult Tobacco Survey Romania (GATS), which is a cross-sectional, nationally representative study. Multivariate logistic regression model was applied for relevant analysis. RESULTS Among males, the regular smoking initiation rate was significantly higher compared to females (52.4% vs. 18.5%; p<0.001). Mean age of smoking initiation was lower in men compared to women (18.4±4.8 vs. 21.5±6.8; p<0.001). Age in men, awareness of environmental tobacco smoke consequences and place of living for women as well as educational attainment and employment status in both genders were associated with ever regular smoking. Moreover, cohabitation with a smoker was associated with greater odds for initiating smoking among both genders. CONCLUSIONS GATS revealed a significant but diverse role of socioeconomic factors in initiation of regular smoking among adult Romanians.
Impact of corporate sustainability reporting on firm performance: an empirical examination in Asia

Purpose The purpose of this paper is to analyse the impact of corporate sustainability reporting on firm performance in four Asian countries – Japan, South Korea, Indonesia and India – and to find out whether there is any significant difference between developed and developing countries of Asia with respect to the impact of such reporting on firm performance. Design/methodology/approach The study is based on 36 listed nonfinancial companies from Japan, 28 from India, 26 from South Korea and 21 from Indonesia respectively, from 2009 to 2014. Content analysis (binary −0 and 1) is used to calculate the disclosure score of sustainability performance, based on Global Reporting Initiative (GRI) format. The outcome of the content analysis is further used to examine the impact of corporate sustainability reporting on firm performance employing a logistic regression model. Findings The study finds that the average level of disclosure is more in the case of Japanese companies (90 per cent), followed by India (88 per cent) and South Korea (85 per cent). On the other hand, the average level of disclosure is only 72 per cent for Indonesian firms. Regression results depict a significant positive association between sustainability reporting and firm’s performance. The study further finds that the relative impact of sustainability reporting on firm performance is more in developed countries than in developing countries of Asia. Originality/value This is the first comprehensive study in Asian context to examine the impact of the level of corporate sustainability disclosure on the firm performance by using the logistic regression model. The outcome of this study would not only help the corporate managers but also the policymakers to make a valuable decision, which will eventually contribute to the objectives of sustainable development.
An Analysis of Relationship between the Environment and User’s Behavior on Unimproved Streets: A Case Study of Da Nang City, Vietnam

One of the most insoluble problems confronted by urban areas in developing countries is the shortage of open space; street space allows daily human activities, promotes social interaction, and is seen as a precondition for the sustainable development of the community. Although some seemingly public space is also built up in Vietnam, street space is often where resident’s go to perform activities. This research aims at studying behaviors of users in old street space and the interaction with existing physical settings; as an input to future renovation and the development of street space in a manner that respects the cultural and social context of the Vietnamese people. User’s behaviors in streets and physical characteristics of space were collected and processed in accordance with theories of behavior setting and proxemics using some methods including place-centered behavioral mapping (PcBM) and visual encounter surveys (VES). The analysis showed that three types of behavior, including (1) Type A where various frequent activities occurred, (2) Type B which discouraged most human activities, and (3) Type C where neither frequent nor infrequent behaviors can represent environmental behavior patterns in the old street spaces of Vietnam and for each of these types of patterns improvements have been proposed by organizing street and pavements layouts detailed in this paper. The proposed improvements are based on the relationship between human behaviors and properties of the street space to assist designers, administers, and authorities in renovating and developing better and more sustainable street space.
The impact of toys as educative curriculum material on pre-service primary school Natural Sciences teachers' understanding of energy

_________________________________________________________________________ In this study toys were used as educative curriculum material in an intervention on the topic of energy aimed at Intermediate Phase pre-service science teachers (n= 87) registered for a BEd degree at the Nelson Mandela Metropolitan University, South Africa. The intervention consisted of, amongst other elements, lectures, assignments and toy workshops, with the latter being a key driver in the process. The choice of toys as the educative curriculum material was informed by the fact that there is a huge variety of simple, reasonably priced and easily procured toys that are suitable to demonstrate the concept of energy from both theoretical and practical perspectives. The conclusions that can be drawn from the study are that the use of toys in the preparation of pre-service primary school teachers has the potential to substantially improve their subject content knowledge (SCK), pedagogical content knowledge (PCK), and their confidence related to these two constructs with respect to their understandings of energy. The data generated also suggest that when appropriate educative curriculum materials are integrated into a topic in science-teacher education, there may be a substantial positive impact on pre-service teachers‘ confidence in both their understanding of the science content and their perceptions of their ability to teach this content. An additional finding of the study was that, despite its popularity, status and usefulness over many years, the Science Teacher Efficacy Belief Instrument (STEBI-B) shows low sensitivity to measuring changes in efficacy as a consequence of the so-called ̳ceiling effect‘. The ceiling effect is a result of initial high scores which provide little opportunity to show
A randomized, placebo‐controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans

Aims: Vitamin D deficiency may increase the risk for type 2 diabetes. African Americans tend to have poor vitamin D status and increased risk of diabetes, but effects of vitamin D supplementation on components of diabetes risk have not been tested in this group. This study was conducted to determine whether vitamin D supplementation improves insulin secretion, insulin sensitivity and glycaemia in African Americans with prediabetes or early diabetes.
Neuropsychological performance is related to current social and occupational functioning in veterans with posttraumatic stress disorder

Background: Several studies have reported deficits in both immediate and delayed recall of verbal memory in patients with posttraumatic stress disorder (PTSD). However, most of these studies had several methodological disadvantages. None of these studies assessed parameters related to social or occupational functioning. Methods: Fifty Dutch veterans of UN peacekeeping missions (25 with PTSD and 25 without PTSD) were assessed with a comprehensive neuropsychological test battery consisting of four subtests of the Wechsler Adult Intelligence Scale‐III, California Verbal‐Learning Test, and the Rey Auditory Verbal‐Learning Test. Veterans with PTSD were free of medication and substance abuse. Results: Veterans with PTSD had similar total intelligence quotient scores compared to controls, but displayed deficits of figural and logical memory. Veterans with PTSD also performed significantly lower on measures of learning and immediate and delayed verbal memory. Memory performance accurately predicted current social and occupational functioning. Conclusions: Deficits of memory performance were displayed in a sample of medication‐ and substance abuse‐free veterans with PTSD. Deficits in memory performance were not related to intelligence quotient, length of trauma exposure, or time since trauma exposure. This study showed that cognitive performance accurately predicted current social and occupational functioning in veterans with PTSD. Depression and Anxiety, 2009. © 2008 Wiley‐Liss, Inc.
Health State Profiles and Service Utilization in Community-Living Elderly

Background:We know that health status in older people is heterogeneous and that many need complex care. What is now required is a comprehensive description of this heterogeneity and the estimation of its effects on patterns of service utilization. Objective:This study examines the possibility of classifying older people according to their complex health conditions and whether the way in which they consume services differs based on these classes. Methods:We used latent class analysis to model heterogeneity and classify community living elderly into homogenous health state categories (ie, health profiles). The number of health profiles present in the sample was revealed using 17 health indicators collected at baseline in the demonstration project of SIPA (French acronym for System of Integrated Care for the frail elderly), a system of integrated care for frail older people (n = 1164). These profiles were then used in 2-part econometric models to study access and costs of several measures of services using data collected prospectively over the 22-months of the SIPA trial. Results:We identified 4 substantially meaningful health profiles (prevalence: 23%, 11%, 36%, 30%) characterized by differences along the physical, cognitive, and disability dimensions of health. Subsequent econometric modeling showed a differential effect of health profiles on use and costs along the continuum of health and social services. Conclusions:For older people with complex care needs, classification into homogeneous health subgroups unmasks differences in utilization patterns that can be used by decision makers in their attempt to improve the trajectory of care and adjust the distribution of resources to the needs of older people.