Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Stone-Wales Defect on Mechanical Properties of Gr/epoxy Nanocomposites

Due to its superior mechanical properties, graphene (Gr) has the potential to achieve high performance polymer-based nanocomposites. Previous studies have proved that defects in the Gr sheets could greatly reduce the mechanical properties of Gr, while the Stone-Wales (SW) defect was found to enhance the interfacial mechanical strength between Gr and epoxy. However, the combined effects of defects on the overall mechanical properties of Gr/epoxy nanocomposites have not been well understood. In this paper, the effect of the SW defect on the mechanical properties of Gr/epoxy nanocomposites was systematically investigated by using molecular dynamic simulations. The simulation results showed that the SW defect would degrade the mechanical properties of nanocomposites, including the Young’s modulus and in-plane shear modulus. Surprisingly, the transverse shear modulus could be remarkably enhanced with the existence of SW. The reinforcing mechanisms were mainly due to two aspects: (1) the SW defect could increase the surface roughness of the Gr, preventing the slippage between Gr and epoxy during the transverse shea; and (2) the nanocomposite with defective Gr enables a higher interaction energy than that with perfect graphene. Additionally, the effects of temperature, the dispersion and volume fraction of Gr were also investigated.
Low back pain websites do not meet the needs of consumers: A study of online resources at three time points

Background: The popularity of the Internet as a source of health-related information for low back pain (LBP) is growing. Although research has evaluated information quality in health-related websites, few studies have considered whether content and presentation match consumer preferences. Objective: The aim of this study was to evaluate whether LBP website content and presentation matched preferences of consumers with LBP, whether matching preference of consumers changed over 8 years as recognition of people-centred healthcare has developed and whether this differs between countries of Internet searching. Method: The most prominent and top 20 LBP websites were identified using common search engines in 2010, 2015 and 2018. Websites identified in the top 20 in 2010 were followed up if not identified in 2015 and 2018. Two reviewers independently evaluated websites with a 16-item checklist developed from research of consumer preferences. In 2015, websites were identified using searches conducted using IP addresses from Australia, the United States of America (USA), the United Kingdom and Canada. After removal of duplicates, 55 websites were evaluated in 2010. In 2015 and 2018, 33 and 28 new sites, respectively, were identified, and 37 previous websites were re-evaluated. Results: In 2010 and 2015, websites predominantly originated from USA and were sponsored by “for-profit” organisations. In 2018, most websites originated from Australian “not-for-profit” organisations. None of the websites provided information on all content areas. At least 55% of websites were rated as poor or fair. No site rated as excellent overall. There was some worsening over time. Country of search did not affect results. Conclusion: Websites retrieved using typical searches did not meet information and presentation preferences of people with LBP.
Does readiness to change influence pain-related outcomes after an educational intervention for people with chronic pain? A pragmatic, preliminary study

ABSTRACT Background: There is a strong association between chronic pain and unhelpful pain cognitions. Educating patients on pain neuroscience has been shown to reduce pain catastrophization, kinesiophobia, and self-perceived disability. This study investigated whether a group-based pain neuroscience education (PNE) session influenced pain-related outcomes, and whether readiness to change moderated these outcomes. Method: In a pragmatic pre-post-intervention study using a convenience sample, adults with chronic pain participated in one, 90–120 minute PNE session. Pain-related outcomes (i.e. pain catastrophization, kinesiophobia, disability, and pain neuroscience knowledge) and the Pain Stage of Change Questionnaire (PSOCQ) were assessed at baseline and immediately post-intervention. Paired t-tests evaluated pre-post changes in outcomes, and linear regression examined the impact of PSOCQ score changes on PNE-induced changes in clinical outcomes. Results: Sixty-five participants were recruited. All outcomes showed positive intervention effects (p < .01). Relationships between changes in PSOCQ subscale scores and change in post-intervention pain-related outcomes were found; ‘Pre-Contemplation’ was positively associated with pain catastrophization (p = .01), and ‘Action’ was negatively associated with kinesiophobia (p = .03). Conclusion: Consistent with previous research, there were improvements in outcomes associated with chronic pain after PNE. Some of these improvements were predicted by changes in PSOCQ scores, however, these findings are preliminary and require further investigation using controlled research designs.
On the motion compensation and geocoding of airborne interferometric SAR data

The paper is concerned about the application of motion compensation algorithms in interferometric SAR data processing. An analysis of the effects of the error induced by the flat Earth assumption in motion compensating the data is included. Possible solutions to this problem via adjustments during and after the SAR processing and the geocoding are also discussed.
An Efficient Extended Targets Detection Framework Based on Sampling and Spatio-Temporal Detection

Excellent performance, real-time and low memory requirement are three vital requirements for target detection in high resolution marine radar system. Unfortunately, many current state-of-the-art methods merely achieve excellent performance when coping with highly complex scenes. In fact, a common problem is that real-time processing, low memory requirement and remarkable detection ability are difficult to coordinate. To address this issue, we propose a novel detection framework which bases its principle on sampling and spatiotemporal detection. The framework consists of two stages, coarse detection and fine detection. Sampling-based coarse detection is designed to guarantee the real-time processing and low memory requirements by locating the area where targets may exist in advance. Different from former detection methods, multi-scan video data are utilized. In the stage of fine detection, the candidate areas are grouped into three categories: single target, dense targets and sea clutter. Different approaches for processing the different categories are implemented to achieve excellent performance. The superiority of the proposed framework beyond state-of-the-art baselines is well substantiated in this work. Low memory requirement of the proposed framework was verified by theoretical analysis. Real-time processing capability was verified by the video data of two real scenarios. Synthetic data were tested to show the improvement in tracking performance by using the proposed detection framework.
Rac1 GTPase Inhibition Blocked Podocyte Injury and Glomerular Sclerosis during Hyperhomocysteinemia via Suppression of Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3 Inflammasome Activation

Elevated homocysteine (Hcy) levels have been shown to activate nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome leading to podocyte dysfunction and glomerular injury. However, it remains unclear how this inflammasome activation in podocytes is a therapeutic target for reversal of glomerular injury and ultimate sclerosis. The present study tested whether inhibition of Rac1 GTPase activity suppresses NLRP3 inflammation activation and thereby blocks podocyte injury induced by elevated Hcy. In cultured podocytes, we found that L-Hcy (the active Hcy form) stimulated the NLRP3 inflammasome formation, as shown by increased colocalization of NLRP3 with apoptosis-associated speck-like protein (ASC) or caspase-1, which was accompanied by increased interleukin-1β production and caspase-1 activity, indicating NLRP3 inflammasome activation. Rac1 activator, uridine triphosphate (UTP), mimicked L-Hcy-induced NLRP3 inflammasome activation, while Rac1 inhibitor NSC23766 blocked it. This Rac1 inhibition also prevented L-Hcy-induced podocyte dysfunction. All these effects were shown to be mediated via lipid raft redox signaling platforms with nicotinamide adenine dinucleotide phosphate oxidase subunits and consequent O2– production. In animal studies, hyperhomocysteinemia (hHcy) induced by folate-free diet was shown to induce NLRP3 inflammasome formation and activation in glomeruli, which was also mimicked by UTP and inhibited by NSC23766 to a comparable level seen in Nlrp3 gene knockout mice. These results together suggest that Rac1 inhibition protects the kidney from hHcy-induced podocyte injury and glomerular sclerosis due to its action to suppress NLRP3 inflammasome activation in podocytes.
Impact of social and occupational factors over job control

Background: Psychosocial risk factors, among which job control has proved to be a key dimension, can have a negative impact on the health of workers. Various research projects have found a relationship between low levels of free time at work and stress and job satisfaction indicators. Objectives: to assess to what extent certain social and employment variables influence “job control”. Methods: A descriptive study was carried out on a sample of workers to analyse the influence of certain socio-demographic and work-related variables on job control, by means of an assessment survey on psychosocial risk and the general state of workers’ health. The tools used in this study were the COPSOQ-ISTAS 21 version 1.5 psychosocial risk assessment questionnaire and a specific survey on the perceived state of health. Results: Three hundred fourteen workers were asked to participate in the study. One hundred and ninety workers completed the questionnaire and were finally included. For the “job control” variable, 47.4% of workers described their situation as good. The results show that workers with a higher educational level (+78%), who have seniority in the job, have a good understanding of their situation at work (+15%), and are employed as white collars (34%), are more likely to show high job control and, therefore, could be less at risk from psychosocial factors. Conclusions: There are two parameters influencing “job control”: social factors concerning educational level, and work situation factors, including seniority and being a white collar worker.
Testosterone propionate can promote effects of acellular nerve allograft‐seeded bone marrow mesenchymal stem cells on repairing canine sciatic nerve

Peripheral human nerves fail to regenerate across long tube implants (>2 cm), and tissue‐engineered nerve grafts represent a promising treatment alternative. The present study aims to investigate the testosterone propionate (TP) repair effect of acellular nerve allograft (ANA) seeded with allogeneic bone marrow mesenchymal stem cells (BMSCs) on 3‐cm canine sciatic nerve defect. ANA cellularized with allogeneic BMSCs was implanted to the defect, and TP was injected into the lateral crus of the defected leg. The normal group, the autograft group, the ANA + BMSCs group, the ANA group, and the nongrafted group were used as control. Five months postoperatively, dogs in the TP + ANA + BMSCs group were capable of load bearing, normal walking, and skipping, the autograft group and the ANA + BMSCs group demonstrated nearly the same despite a slight limp. The compound muscle action potentials (CMAPs) on the injured side to the uninjured site in the TP + ANA + BMSCs group were significantly higher than that in the ANA + BMSCs group [CMAPs ratio at A: F(3, 20) = 191.40; 0.02, CMAPs ratio at B: F(3, 20) = 43.27; 0.01]. Masson trichrome staining revealed that in the TP + ANA + BMSCs group, both the diameter ratio of the myelinated nerve and the thickness ratio of regenerated myelin sheath were significantly larger than that in the other groups [the diameter of myelinated nerve fibers: F(3, 56) = 13.45; P < . 01, the thickness ratio of regenerated myelin sheath: F(3, 56) = 51.25; P < . 01]. In conclusion, TP could significantly increase the repairing effects of the ANA + BMSCs group, and their combination was able to repair 3‐cm canine sciatic nerve defect. It therefore represents a promising therapeutic approach.
A Multiprotein Complex Regulates Interference-Sensitive Crossover Formation in Rice1[OPEN]

In rice, OsSHOC1 and OsPTD constitute an XPF-ERCC1-like complex and collaborate with OsMSH5, OsHEI10, and OsZIP4 to control class I meiotic crossover formation. In most eukaryotes, a set of conserved proteins that are collectively termed ZMM proteins (named for molecular zipper 1 [ZIP1], ZIP2, ZIP3, and ZIP4, MutS homologue 4 [MSH4] and MSH5, meiotic recombination 3, and sporulation 16 [SPO16] in yeast [Saccharomyces cerevisiae]) are essential for the formation of the majority of meiotic crossovers (COs). Recent reports indicated that ZIP2 acts together with SPO16 and ZIP4 to control CO formation through recognizing and stabilizing early recombination intermediates in budding yeast. However, whether this mechanism is conserved in plants is not clear. Here, we characterized the functions of SHORTAGE OF CHIASMATA 1 (OsSHOC1; ZIP2 ortholog) and PARTING DANCERS (OsPTD; SPO16 ortholog) and their interactions with other ZMM proteins in rice (Oryza sativa). We demonstrated that disruption of OsSHOC1 caused a reduction of CO numbers to ∼83% of wild-type CO numbers, whereas synapsis and early meiotic recombination steps were not affected. Furthermore, OsSHOC1 interacts with OsPTD, which is responsible for the same set of CO formations as OsSHOC1. In addition, OsSHOC1 and OsPTD are required for the normal loading of other ZMM proteins, and conversely, the localizations of OsSHOC1 and OsPTD were also affected by the absence of OsZIP4 and human enhancer of invasion 10 in rice (OsHEI10). OsSHOC1 interacts with OsZIP4 and OsMSH5, and OsPTD interacts with OsHEI10. Furthermore, bimolecular fluorescence complementation and yeast-three hybrid assays demonstrated that OsSHOC1, OsPTD, OsHEI10, and OsZIP4 were able to form various combinations of heterotrimers. Moreover, statistical and genetic analysis indicated that OsSHOC1 and OsPTD are epistatic to OsHEI10 and OsZIP4 in meiotic CO formation. Taken together, we propose that OsSHOC1, OsPTD, OsHEI10, and OsZIP4 form multiple protein complexes that have conserved functions in promoting class I CO formation.
One Law with Two Outcomes : Comparing the Implementation of CIPA in Public Libraries and Schools

Though the Children’s Internet Protection Act (CIPA) established requirements for both public libraries and public schools to adopt filters on all of their computers when they receive certain federal funding, it has not attracted a great amount of research into the effects on libraries and schools and the users of these social institutions. This paper explores the implications of CIPA in terms of its effects on public libraries and public schools, individually and in tandem. Drawing from both library and education research, the paper examines the legal background and basis of CIPA, the current state of Internet access and levels of filtering in public libraries and public schools, the perceived value of CIPA, the perceived consequences of CIPA, the differences in levels of implementation of CIPA in public libraries and public schools, and the reasons for those dramatic differences. After an analysis of these issues within the greater policy context, the paper suggests research questions to help provide more data about the challenges and questions revealed in this analysis.
The Paradox of Smoking & Perceived Stress: Do Graphic Health Warnings Influence Smokers under High Stress in Adverse Ways?

ABSTRACT The positive effects of graphic health warnings (GHWs) on quitting smoking have been widely demonstrated in the literature on cigarette warning. However, recent findings of smoker reactance to GHWs demand investigations of factors that may constrain the effects of GHWs. The current study sought to identify conditions in which GHWs do not have a positive impact on smokers’ desire to quit with a focus on smokers’ perceived stress. Two hundred and forty-four smokers in South Korea were exposed to either a text-only or a GHW cigarette pack in a between-subjects experiment. Results from this study suggest that the GHW condition is effective in increasing attention to the GHW, enhancing perceived usefulness of information, and desire to quit only among those with low (vs. high) perceived stress. In addition, an interaction effect between warning type and perceived stress on the desire to quit was sequentially mediated by attention and perceived information effectiveness. Based on the results, we suggest that GHWs were less effective for smokers with high levels of perceived stress because their stress appeared to exhaust the cognitive resources necessary to process the information.
Responses of the kelp Saccharina latissima (Phaeophyceae) to the warming Arctic: from physiology to transcriptomics.

The Arctic region is currently facing substantial environmental changes due to global warming. Melting glaciers cause reduced salinity environments in coastal Arctic habitats, which may be stressful for kelp beds. To investigate the responses of the kelp Saccharina latissima to the warming Arctic, we studied the transcriptomic changes of S. latissima from Kongsfjorden (Svalbard, Norway) over a 24-hour exposure to two salinities (Absolute Salinity (SA ) 20 and 30) after a 7-day pre-acclimation at three temperatures (0, 8 and 15°C). In addition, corresponding physiological data were assessed during an 11-days salinity/temperature experiment. Growth and maximal quantum yield for photosystem II fluorescence were positively affected by increased temperature during acclimation, whereas hyposalinity caused negative effects at the last day of treatment. In contrast, hyposalinity induced marked changes on the transcriptomic level. Compared to the control (8°C - SA 30), the 8°C - SA 20 exhibited the highest number of differentially expressed genes (DEGs), followed by the 0°C - SA 20. Comparisons indicate that S. latissima tends to convert its energy from primary metabolism (e.g. photosynthesis) to antioxidant activity under hyposaline stress. The increase in physiological performance at 15°C shows that S. latissima in the Arctic region can adjust and might even benefit from increased temperatures. However, in Arctic fjord environments its performance might become impaired by decreased salinity as a result of ice melting. This article is protected by copyright. All rights reserved.
Is enrolment in the national health insurance scheme in Ghana pro-poor? Evidence from the Ghana Living Standards Survey

Objectives This article examines equity in enrolment in the Ghana National Health Insurance Scheme (NHIS) to inform policy decisions on progress towards realisation of universal health coverage (UHC). Design Secondary analysis of data from the sixth round of the Ghana Living Standards Survey (GLSS 6). Setting Household based. Participants A total of 16 774 household heads participated in the GLSS 6 which was conducted between 18 October 2012 and 17 October 2013. Analysis Equity in enrolment was assessed using concentration curves and bivariate and multivariate analyses to determine associated factors. Main outcome measure Equity in NHIS enrolment. Results Survey participants had a mean age of 46 years and mean household size of four persons. About 71% of households interviewed had at least one person enrolled in the NHIS. Households in the poorest wealth quintile (73%) had enrolled significantly (p<0.001) more than those in the richest quintile (67%). The concentration curves further showed that enrolment was slightly disproportionally concentrated among poor households, particularly those headed by males. However, multivariate logistic analyses showed that the likelihood of NHIS enrolment increased from poorer to richest quintile, low to high level of education and young adults to older adults. Other factors including sex, household size, household setting and geographic region were significantly associated with enrolment. Conclusions From 2012 to 2013, enrolment in the NHIS was higher among poor households, particularly male-headed households, although multivariate analyses demonstrated that the likelihood of NHIS enrolment increased from poorer to richest quintile and from low to high level of education. Policy-makers need to ensure equity within and across gender as they strive to achieve UHC.
The impact of macroscopic on-site evaluation using filter paper in EUS-guided fine-needle biopsy

Background and Objectives: EUS-guided tissue acquisition with rapid on-site cytologic evaluation (ROSE) has been used to increase the diagnostic yield. However, ROSE is not available in many centers. To date, only a few studies have assessed the adequacy of histologic cores in macroscopic on-site evaluation (MOSE) during EUS-guided fine-needle biopsy (EUS-FNB). Blood contamination of histologic core specimens lowers the sample quality and the diagnostic yield. Therefore, we evaluated the efficacy of MOSE using filter paper to increase the adequacy of histologic core specimens while minimizing blood contamination. Materials and Methods: Seventy-nine consecutive patients with an intraabdominal mass underwent EUS-FNB between March 2017 and October 2018. Histologic specimens obtained using EUS-FNB were expelled onto filter paper, and the histologic procurement rate on MOSE was evaluated. Results: EUS-FNB using a 20-gauge Procore needle or a 22-gauge Acquire needle was successful in all patients. The mean number of needle passes was 2.8 ss0.8. Visible histologic cores were observed in 94.9% (75/79) of the patients. Blood-contaminated specimens with scanty histologic cores were obtained in 5.1% (4/79) of the patients. On microscopic examination, 92.4% (73/79) of the histologic samples were graded as optimal. The diagnostic accuracy, sensitivity, and specificity were 94.5%, 94.3%, and 100%, respectively. Mild postprocedural adverse events occurred in 2 patients (2.5%: n = 1, transient fever; n = 1, acute pancreatitis). Conclusions: MOSE using filter paper provided adequate histologic samples while minimizing blood contamination. MOSE can also increase the diagnostic accuracy when ROSE is not available.
Stabilization of Nonautonomous Recurrent Neural Networks With Bounded and Unbounded Delays on Time Scales

A class of nonautonomous recurrent neural networks (NRNNs) with time-varying delays is considered on time scales. Bounded delays and unbounded delays have been taken into consideration, respectively. First, a new generalized Halanay inequality on time scales is constructed by time-scale theory and some analytical techniques. Based on this inequality, the stabilization of NRNNs with bounded delays is discussed on time scales. The results are also applied to the synchronization of a class of drive–response NRNNs. Furthermore, the stabilization of NRNNs with unbounded delays is investigated. Especially, the stabilization of NRNNs with proportional delays is obtained without any variable transformation. The obtained generalized Halanay inequality on time scales develops and extends some existing ones in the literature. The stabilization criteria for the NRNNs with bounded or unbounded delays cover the results of continuous-time and discrete-time NRNNs and hold the results for the systems that involved on time interval as well. Some examples are given to demonstrate the validity of the results. An application to image encryption and decryption is addressed.