Miracle-dz/UniFAR-FTUs huggingface dataset:
Reliability of Pressure Ulcer Staging: A Review of Literature and 1 Institution's Strategy

Pressure ulcers are an increasing health care problem. Accurate identification and classification of pressure ulcers impacts patient outcomes, health care costs, and quality initiatives.To identify existing evidence related to answering the question “Does bedside nursing staff accurately and reliably stage pressure ulcers as evidenced in their documentation? ” Further evidence from one large tertiary care center with pressure ulcer identification and staging by nurses is also reported.Cumulative Index to Nursing and Allied Health Literature and MEDLINE databases were searched to identify existing evidence on the accuracy and reliability of pressure ulcer classification by nurses. Two reviewers independently screened results. A total of 54 full-text articles were obtained for review and 10 were included for final review. In addition, the accuracy and consistency of pressure ulcer identification and staging were examined at one large tertiary health system by extracting data from electronic health records for 1488 patient visits and assessments for 1499 patients. Comparisons were done for pressure ulcer documentation from 1 nurse's assessment to the following shift nurse's assessment and from the bedside nurse's assessment to assessments done by pressure ulcer experts.Review of the literature revealed that the reliability of pressure ulcer identification and classification is limited and highly variable. Some reports in the literature suggested nurses had difficulty distinguishing a pressure ulcer from other types of wounds. In addition, inaccuracies in pressure ulcer documentation were also identified. Further analysis of data within one large tertiary health care system revealed unreliable pressure ulcer documentation.
A systematic review of disability awareness interventions for children and youth

Purpose: Children’s lack of knowledge about disability can adversely impact their attitudes toward people with disabilities. The purpose of this study is to review the common elements of effective disability awareness interventions. Methods: A systematic review of disability awareness interventions for children and youth was conducted to assess the effective components of these interventions. Electronic searches were conducted using OVID, CENTRAL, PsychInfo, ERIC, Social Science Citation Index, GreyNET Scopus and Google Scholar. The inclusion criteria included (i) an intervention raising awareness about disability, (ii) school-age children with the average age between 5–19 years old, (iii) at least one measurable outcome focusing on knowledge about disability or attitudes towards and/or acceptance of people with a disability and (iv) published article or grey literature. Results: Of the 1031 articles that were identified in the search, 42 met the criteria to be included in the review. We classified the disability awareness interventions into 5 broad types including (i) social contact, (ii) simulation, (iii) curriculum, (iv) multi-media curriculum and (v) multiple components. Thirty-four studies showed an improvement in attitudes towards and/or acceptance of peers with disabilities. Eight of these studies also demonstrated an improvement in knowledge of people with disabilities. Five of the interventions found no support for improving knowledge about, or acceptance of people with disabilities. Conclusion: Disability awareness interventions can successfully improve children’s knowledge about and attitudes towards peers with a disability; they should include several different components over multiple sessions. Relevance: These findings are being used to further develop disability awareness interventions to help improve the social inclusion and participation of children with disabilities within mainstream classrooms. Implications for Rehabilitation Well-designed disability awareness interventions for children and youth can help improve knowledge about disability, attitudes towards people with a disability and acceptance of peers with a disability. Rehabilitation health care providers and educators should be trained to recognize when children with disabilities are being socially excluded and be prepared to provide or recommend appropriate resources and interventions on how to address this issue. Clinicians, educators and children with disabilities should all be involved in the development of disability awareness programs. Educators should carefully choose an appropriate intervention to meet the needs of the children in their class while considering age appropriateness and diversity of the students. It is also important for educators to be cognizant of the broader societal influences that impact attitudes towards disability.
Receptive Field Self-Organization in a Model of the Fine Structure in V1 Cortical Columns

Abstract We study a dynamical model of processing and learning in the visual cortex, which reflects the anatomy of V1 cortical columns and properties of their neuronal receptive fields. Based on recent results on the fine-scale structure of columns in V1, we model the activity dynamics in subpopulations of excitatory neurons and their interaction with systems of inhibitory neurons. We find that a dynamical model based on these aspects of columnar anatomy can give rise to specific types of computations that result in self-organization of afferents to the column. For a given type of input, self-organization reliably extracts the basic input components represented by neuronal receptive fields. Self-organization is very noise tolerant and can robustly be applied to different types of input. To quantitatively analyze the system's component extraction capabilities, we use two standard benchmarks: the bars test and natural images. In the bars test, the system shows the highest noise robustness reported so far. If natural image patches are used as input, self-organization results in Gabor-like receptive fields. In quantitative comparison with in vivo measurements, we find that the obtained receptive fields capture statistical properties of V1 simple cells that algorithms such as independent component analysis or sparse coding do not reproduce.
Finger tissue model and blood perfused skin tissue phantom

Measurements of optical properties of fingernail and underlying tissues using OCT are presented. Review and measurements of Raman spectra of tissue and phantom compounds were done. Updating of modeling algorithm for scattering coefficient calculation on the basis of integrating sphere measurements accounting for particle size-distribution was also done. The adequate fingernail and underlying tissue optical model at 830 nm was evaluation. Tissue phantoms potentially suitable for calibration of Raman instrumentation for glucose sensing were designed and tested on the basis of epoxy resin, TiO2-nanoparticles and micron-sized silica particles with the capillary net-work.
Induced Systemic Resistance and Promotion of Plant Growth by Bacillus spp.

ABSTRACT Elicitation of induced systemic resistance (ISR) by plant-associated bacteria was initially demonstrated using Pseudomonas spp. and other gram-negative bacteria. Several reviews have summarized various aspects of the large volume of literature on Pseudomonas spp. as elicitors of ISR. Fewer published accounts of ISR by Bacillus spp. are available, and we review this literature for the first time. Published results are summarized showing that specific strains of the species B. amyloliquefaciens, B. subtilis, B. pasteurii, B. cereus, B. pumilus, B. mycoides, and B. sphaericus elicit significant reductions in the incidence or severity of various diseases on a diversity of hosts. Elicitation of ISR by these strains has been demonstrated in greenhouse or field trials on tomato, bell pepper, muskmelon, watermelon, sugar beet, tobacco, Arabidopsis sp. , cucumber, loblolly pine, and two tropical crops (long cayenne pepper and green kuang futsoi). Protection resulting from ISR elicited by Bacillus spp. has been reported against leaf-spotting fungal and bacterial pathogens, systemic viruses, a crown-rotting fungal pathogen, root-knot nematodes, and a stem-blight fungal pathogen as well as damping-off, blue mold, and late blight diseases. Reductions in populations of three insect vectors have also been noted in the field: striped and spotted cucumber beetles that transmit cucurbit wilt disease and the silver leaf whitefly that transmits Tomato mottle virus. In most cases, Bacillus spp. that elicit ISR also elicit plant growth promotion. Studies on mechanisms indicate that elicitation of ISR by Bacillus spp. is associated with ultrastructural changes in plants during pathogen attack and with cytochemical alterations. Investigations into the signal transduction pathways of elicited plants suggest that Bacillus spp. activate some of the same pathways as Pseudomonas spp. and some additional pathways. For example, ISR elicited by several strains of Bacillus spp. is independent of salicylic acid but dependent on jasmonic acid, ethylene, and the regulatory gene NPR1-results that are in agreement with the model for ISR elicited by Pseudomonas spp. However, in other cases, ISR elicited by Bacillus spp. is dependent on salicylic acid and independent of jasmonic acid and NPR1. In addition, while ISR by Pseudomonas spp. does not lead to accumulation of the defense gene PR1 in plants, in some cases, ISR by Bacillus spp. does. Based on the strains and results summarized in this review, two products for commercial agriculture have been developed, one aimed mainly at plant growth promotion for transplanted vegetables and one, which has received registration from the U.S. Environmental Protection Agency, for disease protection on soybean.
Histamine deficiency promotes accumulation of immunosuppressive immature myeloid cells and growth of murine gliomas

To elucidate mechanisms underlying epidemiological findings of decreased risk of glioma development in patients with allergies and asthma, gliomas were induced in mice deficient for histidine decarboxylase (HDC), the enzyme responsible for histamine production. These mice exhibited shortened survival and enhanced tumor growth compared to wild-type (WT) mice. Previous studies have shown a pivotal role of HDC in maturation of bone marrow (BM)-derived myeloid cells. In our glioma models, brain-infiltrating leukocytes (BIL) demonstrated an increased frequency of CD11b+Gr1+ immature myeloid cells (IMC; both CD11b+Ly6G+ and CD11b+Ly6C+ subpopulations) as well as diminished CD8+ T cell infiltration and their effector functions in HDC−/− mice compared with WT mice. Furthermore, HDC−/− IMC demonstrated a more profound immune suppression of CD8+ T cell proliferation and functions associated with increased prostaglandin E2 (PGE2) expression levels. Celecoxib, a cyclooxygenase-2 inhibitor, which is vital for PGE2 production, abrogated suppressive capabilities of HDC−/− IMC. In addition, glioma-bearing HDC-eGFP mice, in which HDC promoter drives green fluorescence protein (GFP) expression, exhibited decreased HDC promoter activities in CD11b+Gr1+ cells in the BM, spleen, and intracranial tumor site compared with non-tumor bearing HDC-eGFP mice. Additionally, in vitro culture with glioma supernatants decreased GFP expression in CD11b+Gr1+, CD11b+Ly6G+, and CD11b+Ly6C+ IMC. HDC expression levels inversely correlated with suppressive functions of CD11b+Gr1+ IMC, as GFP−CD11b+Gr1+ more profoundly inhibited CD8+ T cell proliferation compared with CD11b+Gr1+GFP+ cells. Taken together, these data show a significant role of HDC in the glioma microenvironment via maturation of myeloid cells and resulting activation of CD8+ T cells.
TTF-1 Expression in Ovarian and Uterine Epithelial Neoplasia and its Potential Significance, an Immunohistochemical Assessment With Multiple Monoclonal Antibodies and Different Secondary Detection Systems

Thyroid transcription factor-1 (TTF-1) is a 38-kd homeodomain containing DNA-binding protein, identified in thyroid and lung as a regulator of thyroid-specific genes and surfactant and Clara cell secretory protein gene expression. TTF-1 has been used as a reliable lineage marker for lung adenocarcinoma and thyroid carcinoma in surgical pathology. However, TTF-1 expression has been recently reported in carcinomas of other origins including female genital tract. We evaluated TTF-1 expression with 3 primary different antibodies (8G7G3/1, SPT24, and BGX-397A) and 2 secondary automated detection systems (Envision+/Dako autostainer versus Refine/Bond Max) in 104 ovarian and endometrial tumors on routine surgical specimens and 108 ovarian tumors on tissue microarray (TMA) specimens. SPT24 and Refine/Bond Max autostainer was the most sensitive system among the primary antibodies and secondary detection/autostainers tested. By using SPT24/Refine/Bond Max, TTF-1 reactivity could be detected in all major histologic subtypes of gynecologic tumors and up to 26% of all cases tested on routine surgical specimens and 6.4% on TMA. TTF-1 was most frequently detected in uterine malignant mixed Müllerian tumor (82%), more common in uterine tumors than ovarian tumors, and more common in surgical specimen than TMA. When present, tumor cells can be rarely positive or diffusely positive for TTF-1 reactivity. In addition to malignant tumors, TTF-1 was also detected in benign tumors and benign tubal and endometrial epithelia. TTF 1 immunostaining has the potential to misguide a pathologist to conclude an ovarian or endometrial tumor being a lung metastasis. However, the role of TTF-1 in female genital tract and its tumors is unknown.
decerebrate and conscious cats medulla to whole body rotations: comparisons in Responses of neurons in the rostral ventrolateral

You might find this additional info useful.This article cites 51 articles, 25 of which can be accessed free at:http://jap.physiology. org/content/110/6/1699.full. html#ref-list-1 Updated information and services including high resolution figures, can be found at:http://jap.physiology. org/content/110/6/1699.full. html Additional material and information about Journal of Applied Physiology can be found at:http://www.the-aps.org/publications/japplThis infomation is current as of June 13, 2011. €
Higher incidence of hysterectomy and oophorectomy in women suffering from clinical depression: Retrospective chart review

The aim of the present study was to retrospectively evaluate women who were admitted to Hiroshima University Hospital, Department of Psychiatry and Neurosciences, from 1979 to 2008. The women were classified as ‘depressed women’ (n = 159; mean age, 52.3 ± 5.7 years) or ‘non‐depressed women’ (n = 182; mean age, 51.5 ± 4.5 years). A total of 14.5% of the depressed women and 3.3% of the non‐depressed women had a hysterectomy and/or oophorectomy; this difference was statistically significant (P = 0.0003). This is consistent with previous reported information as well as clinical experience that depressed women had a higher incidence of hysterectomy and/or oophorectomy.
Robust Classification using Robust Feature Augmentation

Existing deep neural networks, say for image classification, have been shown to be vulnerable to adversarial images that can cause a DNN misclassification, without any perceptible change to an image. In this work, we propose shock absorbing robust features such as binarization, e.g., rounding, and group extraction, e.g., color or shape, to augment the classification pipeline, resulting in more robust classifiers. Experimentally, we show that augmenting ML models with these techniques leads to improved overall robustness on adversarial inputs as well as significant improvements in training time. On the MNIST dataset, we achieved 14x speedup in training time to obtain 90% adversarial accuracy com-pared to the state-of-the-art adversarial training method of Madry et al., as well as retained higher adversarial accuracy over a broader range of attacks. We also find robustness improvements on traffic sign classification using robust feature augmentation. Finally, we give theoretical insights for why one can expect robust feature augmentation to reduce adversarial input space
Delirium management in patients with cancer: Dosing of antipsychotics in the delirium subtypes and response to psychopharmacological management

Background: While delirium resolution and persistent delirium in hypoactive and hyperactive delirium have been studied to a certain extent, doses of antipsychotics administered remain unknown. Methods: Patients treated for cancer were recruited at the Memorial Sloan Kettering Cancer Center (MSKCC). Socio- demographic, medical variables, the Memorial Delirium Assessment Scale (MDAS) subitems (1-10) as well as the Karnofsky scale of Performance Status (KPS) were recorded at baseline (T1), 2-3 days (T2) and 4-7 days (T3) and analyzed in respect to the subtypes of delirium and medication doses administered. Results: Between haloperidol, risperidone, olanzapine and aripiprazole, differences existed in respect to the prevalence of dementia, stage of illness, baseline MDAS scores, delirium resolution, and functional status. When hyperactive delirium was present, doses reached fourfold those administered in hypoactive delirium. In particular, haloperidol and olanzapine were administered at higher doses in order to achieve symptom control. When aripiprazole was administered, dosing was similar between the subtypes. Generally, the response to management with antipsychotics was similar between the delirium subtypes, although a trend towards a greater response in hypoactive delirium was noted. However, factors known to cause persistent delirium influenced delirium resolution. Conclusion: The interaction of factors contributing to resolved and persistent delirium in the hypoactive and hyperactive subtype remains complex. In general, the response was comparable between the subtypes. However, patients with hyperactive delirium required higher doses of antipsychotics in order to achieve symptom control
Bringing Manifold Learning and Dimensionality Reduction to SED Fitters

We show that unsupervised machine learning techniques are a valuable tool for both visualizing and computationally accelerating the estimation of galaxy physical properties from photometric data. As a proof of concept, we use self-organizing maps (SOMs) to visualize a spectral energy distribution (SED) model library in the observed photometry space. The resulting visual maps allow for a better understanding of how the observed data maps to physical properties and allows for better optimization of the model libraries for a given set of observational data. Next, the SOMs are used to estimate the physical parameters of 14,000 z ∼ 1 galaxies in the COSMOS field and are found to be in agreement with those measured with SED fitting. However, the SOM method is able to estimate the full probability distribution functions for each galaxy up to ∼106 times faster than direct model fitting. We conclude by discussing how this acceleration, as well as learning how the galaxy data manifold maps to physical parameter space and visualizing this mapping in lower dimensions, helps overcome other challenges in galaxy formation and evolution.
Experimental cutaneous leishmaniasis: transmission electron microscopy of the inoculation site

Tissue response against inoculation of Leishmania (Leishmania) amazonensis promastigotes in the hind footpad was quite different between two strains of mice: in BALB/c animals there was parasitism of perineurial cells by the 8th week post inoculation (WPI) and heavy parasitism of macrophages, as well as degenerated extracellular parasites close to collagen fibers at the 39th WPI, whereas in C57Bl/6j mice there was heavy parasitism of macrophages at 6th WPI, dermal vessels with high endothelial cell at 21st WPI and well preserved intracellular amastigote forms by 51st WPI. In both animals there was no parasitism of keratinocytes or Langerhans cells. Thus BALB/c mice were useful as an experimental model for diffuse cutaneous leishmaniasis and showing a new feature, parasitism of perineurial cells, whereas C57Bl/6j animals show hypersensitivity signs, together with a few preserved parasites, only late in the course of infection. From a morphological point of view, there were no differences in macrophages, or in the interaction between this target cell and the parasite, between the animal models studied. This suggests that the difference in the response of the hosts towards the parasite could depend on the way in which they activate a cellular, i.e. lymphocyte mediated immune, response.
ADULT‐ONSET FOVEOMACULAR PIGMENT EPITHELIAL DYSTROPHY: Clinicopathologic Correlation of Three Cases

Purpose: The authors describe the clinicopathologic features of three patients with adult onset foveomacular pigment epithelial dystrophy (AOFPED). Methods: The eyes of three patients were studied ophthalmoscopically and by fiuorescein angiography, and obtained postmortem and studied by light and electron microscopy. Results: Histopathologic study of the three patient's eyes disclosed central loss of the retinal pigment epithelium and photoreceptor cell layer with a moderate number of pigment‐containing macrophages present in the subretinal space and outer retina. To either side, the retinal pigment epithelium was distended with much lipofuscin. Basal laminar and basal linear deposits were present throughout the central area. No discontinuities of Bruch membrane were present. Conclusion: The findings in the eyes of three patients with AOFPED included marked aging changes that are similar to those seen in age‐related macular degeneration. Pigmented cells with lipofuscin in the subretinal space account for the vitelliform appearance.
Functions of the 126- and 183-kDa proteins of tobacco mosaic virus.

Tobacco mosaic virus produces two proteins that contain domains similar to the methyltransferase (MT) and helicase (HEL)-like domains of the replicase-associated proteins of other RNA viruses. The more abundant 126-kDa protein contains only the MT and HEL-like domains, whereas the 183-kDa readthrough protein additionally contains the polymerase domain. We examined the functions of these proteins by constructing a bipartite system to express the 126- and 183-kDa proteins from separate RNAs. Mutants expressing the 183-kDa protein recognized promoters for negative- and positive-stranded RNA synthesis, transcribed subgenomic mRNAs, capped RNAs, synthesized proteins, moved cell to cell within the plant, and replicated defective RNAs (dRNAs). The principal function of the 126-kDa protein was to increase the rate of replication approximately tenfold. The 126-kDa protein appeared to function primarily in cis, and production of the 126-kDa protein in trans did not enhance replication of the helper virus. dRNAs producing a functional 126-kDa protein were replicated efficiently by helper viruses that produced only the 183-kDa protein but not by wild-type virus, suggesting that efficient replication required the 183-kDa protein to form a heterodimer with the 126-kDa protein already bound to the target dRNA.