Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Soft and Extreme Action in Public Complaint Behavior on Satisfaction with Complaint Handling

Malaysia is experiencing a tremendous increase in mobile phone services users. Service providers are providing various complaint channels as one of the ways to improve services. Although complaining provides significant impact to organizations as well as to complainers or consumers, ironically the number of public complaints is insignificant. Based on previous study, two actions in public complaint namely public complaint soft action and public complaint extreme action were used in this study as the exogenous variables and satisfaction with complaint handling (SATCOM) as the endogenous variable. A total of 285 complainers of mobile phone user were selected as respondents. The values for goodness-of-fit, average variance extracted, construct reliability and convergent validity confirmed the measurement model prior proceeding to structural model. The structural model revealed mixed results that provide indication of consumer SATCOM specifically in the mobile phone service industry.
The Majority of the Saccharomyces cerevisiae Septin Complexes Do Not Exchange Guanine Nucleotides*

We show here that affinity-purified Saccharomyces cerevisiae septin complexes contain stoichiometric amounts of guanine nucleotides, specifically GTP and GDP. Using a 15N-dilution assay read-out by liquid chromatography-tandem mass spectrometry, we determined that the majority of the bound guanine nucleotides do not turn over in vivo during one cell cycle period. In vitro, the isolated S. cerevisiae septin complexes have similar GTP binding and hydrolytic properties to the Drosophila septin complexes (Field, C. M., al-Awar, O., Rosenblatt, J., Wong, M. L., Alberts, B., and Mitchison, T. J. (1996) J. Cell Biol. 133, 605-616). In particular, the GTP turnover of septins is very slow when compared with the GTP turnover for Ras-like GTPases. We conclude that bound GTP and GDP play a structural, rather then regulatory, role for the majority of septins in proliferating cells as GTP does for α-tubulin.
Proteomic comparison of oligodendrogliomas with and without 1pLOH

Objective: Chemoresistance is a widespread therapeutic challenge in glial tumors. The molecular basis of chemoresistance is poorly understood, precluding advances in glioma treatment and leaving gliomas among the most lethal tumors. Oligodendrogliomas provide a unique model to study the molecular basis of chemoresistance, as there are two distinct genetic subtypes with significant differences in chemosensitivity. Despite a high morphological similarity, tumors with allelic loss on the short arm of chromosome 1 (1pLOH) are more chemosensitive than those without 1pLOH. Methods: In order to identify candidate proteins potentially responsible for glioma chemosensitivity, we compared the proteome of four oligodendrogliomas with and five without 1pLOH using comparative proteomic profiling. Proteomic analysis was performed by two-dimensional protein gel electrophoresis and subsequent computerized gel analysis for detection of distinguishing patterns of protein expression. Differentially expressed proteins were identified using Liquid Chromatography/Mass Spectrometry. Differential expression of select proteins was confirmed by Western blotting. Results: We identified seven candidate proteins that are overexpressed in oligodendrogliomas without 1pLOH. Two of these proteins (glyoxalase I and Rho GDP dissociation inhibitor) have previously been shown to enhance chemoresistance in other tumors. In turn, we identified twelve overexpressed proteins in tumors with 1pLOH that have previously been reported to induce chemosensitivity in other forms of human neoplasia. Conclusions: These identified proteins are potential targets for pharmacological therapy and may also be useful as biomarkers for differentiation of chemoresistant and chemosensitive oligodendroglioma.
Intrahousehold Resource Allocation in Rural Pakistan: A Semi-Parametric Analysis

We estimate semiparametric Engel curves for rural Pakistan using a large household survey. This allows us to obtain consistent estimates of the effects of household size and composition on consumption patterns even when these demographic variables are correlated with an unknown function of income. The coefficients on the household composition variables are used to infer patterns of intrahousehold allocation. While there is little evidence of gender bias amongst children, adult males appear to get more than adult females. There is a tendency amongst males for workers to get more than dependents. There is no evidence of differential treatment of the elderly and higher birth-order children. We identify substantial economies of size in food consumption. We also find that Engel curces for food, adult goods and child goods are nonlinear, which suggests that the PIGLOG class of demand models in inappropriate.
A Lack of Antinociceptive or Antiinflammatory Effect of Botulinum Toxin A in an Inflammatory Human Pain Model

Several in vitro and in vivo investigations have shown that botulinum toxin A (BoNT/A) can inhibit the release of substance P and excitatory amino acids. Recently, a marked antinociceptive effect of BoNT/A and inhibition of glutamate release was observed in an animal pain model with inflammatory sensitization. In the present study, we tested the antiinflammatory and antihyperalgetic effect of BoNT/A in a well-characterized human inflammatory pain model. Using a randomized, double-blind, paired study design, we compared the effects of 100 mouse units of BoNT/A versus pure saline. Thermal and mechanical pain testings and superficial skin blood flow measurements were performed at baseline, at 48 h (in normal skin), and at 72 h (in inflamed skin) thereafter. Ultraviolet B irradiation resulted in a local inflammation with significant primary and secondary hyperalgesia. However, despite the evidence of efficacy on sudomotor function, BoNT/A had no effect on pain measures in either normal or inflamed skin. Signs of inflammation and primary and secondary hyperalgesia were found to be unaffected by BoNT. We have confirmed that BoNT/A has no direct effect on acute, noninflammatory pain. Furthermore, despite highly promising data from animal research, we have not observed antiinflammatory or antinociceptive effects of BoNT/A in human inflammatory pain.
The action of 5‐hydroxytryptamine and related compounds on neuromuscular transmission in the locust Schistocerca gregaria

:! _! indolalkylamine in the search for an antagonist to 5-HT on our pre- :: paration. We also tested as possible antagonists lysergic acid diethylamide i . (LSD) and bromolysergic acid diethylamide (BOL) which are known to i act as antagonists to 5-HT in other invertebrate preparations (Welsh, 1957a), probably by virtue of irreversibly imitating 5-HT. 3-(pyrrolidino- i methyl)-thionaphthene is known to be one hundred times as active as
Identifying the Problem Drinker on the Job

Not too long ago, the employee with a drinking problem was regarded as something of a moral degenerate and, after numerous "last chances," was eventually discharged. Today, however, new attitudes toward such employees are emerging in management. Many companies now recognize alcoholism as a form of illness. Having decided that it is better policy to rehabilitate the problem drinker than to fire him, they have worked out specific personnel programs and procedures toward this end. In short, the current trend is toward therapy, rather than punishment. This change of attitude may be attributed in large part to the new information about the problem drinker that has been made available over the past eight years. It is now known tha t the alcoholic can be restored to health and that, in view of the heavy costs of alcoholism to management itself, the attempt to rehabilitate long-time, able employees is eminently worth while.
Paradoxical Effects of Opioid Antagonist Naloxone on SSRI-Induced Analgesia and Tolerance in Mice

Selective serotonin reuptake inhibitors (SSRIs) have been used clinically as co-analgesics in various devastating painful conditions. Upon chronic treatment tolerance develops to their analgesic effect, which is often refractory to increasing dose. Although modulation of serotonergic pathways considerably explains their clinical efficacy, numerous reports nevertheless indicate the direct/indirect role of the opioidergic pathway in SSRI-induced analgesia. The present study was designed to investigate the effect, if any, of the opioid antagonist naloxone on SSRIs-induced analgesia and tolerance employing acetic acid-induced writhing assay. Two SSRIs, fluoxetine (FLX), and citalopram (CTP) were used in the study. Acute systemic (5–40 mg kg–1 i.p.), or intrathecal (5–40 µg per mouse, i.t.) administration of fluoxetine or citalopram exhibited a dose-dependent and significant (p < 0.05) antinociceptive effect. Single systemic (2–5 mg kg–1 i.p.) or intrathecal (1 µg per mouse, i.t.) administration of opioid antagonist naloxone blocked where as systemic ultra-low dose (10 ng/kg) or intrathecal (0.05 ng) naloxone potentiated the acute antinociceptive effect of both SSRIs (10 mg kg–1 i.p. and 10 µg i.t.). Animals treated chronically over a 7-day period with SSRIs developed tolerance to their antinociceptive effect. Further, chronic administration of ultra-low dose of naloxone intrathecal (0.05 ng per mouse, i.t.) or systemic (10 ng kg–1 i.p.) with fluoxetine or citalopram (10 µg i.t.; 5 mg kg–1 i.p.) over a 7-day period reversed the tolerance to the antinociceptive effect of SSRIs. Thus, in ultra-low doses, naloxone paradoxically enhances SSRIs-induced analgesia and reverse tolerance through spinal and peripheral action. These effects of opioid antagonist naloxone on SSRIs-induced antinociception may have an implication in refractory cases upon chronic use of SSRIs as co-analgesics.
High prevalence and low fecundity of mental disorders may reflect recessive effects.

To the Editor Power and colleagues 1 appropriately raise the question of why mental disorders that have substantial genetic contributions to etiology and are associated with low fecundity should continue to be highly prevalent in the face of selection pressure. However, they fail to consider what may be an important explanatory factor, which is that recessively acting effects may contribute to risk. Recessively acting alleles are subjected to relatively little selection pressure, especially when there are many different pathogenic mutations, each individually rare, that can form compound heterozygotes to produce disease. Such alleles can then be cumulatively quite common in the population even without bestowing any marked heterozygous advantage. I have recently discussed these issues with respect to schizophrenia and pointed out that recessive effects are consistent with the observed genetic epidemiology. 2 This is an important issue because the presence of compound heterozygotes among cases will not be picked up by conventional methods for analyzing either genome-wide association analyses or next-generation sequencing data. Indeed, this may explain the failure to date to identify sequence variations having a major effect on risk. I have advocated that specialist statistical methods be developed with the explicit aim of detecting whether recessive effects, manifest as different mutations in the same gene-forming compound heterozygotes, may make a significant contribution to the risk of schizophrenia. These considerations apply also to other disorders that have a markedly adverse impact on reproductive fitness.
Experiences of pregnant adolescents--voices from Wakiso district, Uganda.

BACKGROUND In Uganda, morbidity and mortality among adolescent mothers and their children are high. Social factors behind this problem need to be better understood. OBJECTIVE To explore problems that pregnant adolescents face in order to design appropriate policies and interventions. METHODS This was a descriptive study that utilized qualitative methods for data collection. The study population comprised of pregnant adolescents, adolescent mothers, opinion leaders, In-charge of health unit, and Traditional Birth Attendants (TBAs) in Wakiso district, Uganda. Six Focus Group Discussions (FGDs) with adolescent mothers and pregnant adolescents, and six key informant interviews were conducted with leaders in-charge of health units and TBAs. A moderator and a note taker facilitated the FGDs, which were tape recorded with consent from participants. Qualitative content analysis was done. RESULTS Discussions revealed that pregnant adolescents faced domestic physical violence. Furthermore, they were psychologically violated by parents and partners, and the community within which they lived. Pregnant adolescents were treated inhumanely and overworked with household chores and had inadequate food to eat. Adolescents experienced stigma and as a result some had carried out unsafe abortions. Key informant interviews and FGDs revealed that health workers were rude and unsympathetic to pregnant adolescents. This significantly contributed to delayed health care seeking when adolescents were ill. CONCLUSION Pregnant adolescents lack basic needs like shelter, food and security. They also face relational problems with families, partners and the community. There is, therefore, a need to sensitize the community and school personnel about adolescent reproductive health issues. In addition, adolescent friendly services need to be established/strengthened. Continuous in-service training for health workers with emphasis on counseling skills for young people is urgently needed.
Comparative Ecophysiology of Cold-Tolerance-Related Traits: Assessing Range Expansion Potential for an Invasive Insect at High Latitude

Survival at high latitude requires the capability to cope with seasonally imposed stress, such as low winter temperatures or large temperature fluctuations. The Colorado potato beetle, Leptinotarsa decemlineata, is an invasive pest of potato that has rapidly spread from low latitudes to higher latitudes. During the last 30 years, a decrease in range expansion speed is apparent in Europe. We use a comparative approach to assess whether this could be due to an inability of L. decemlineata to cope with the harsher winters encountered at high latitude, when compared to two native northern chrysomelid beetles with similar overwintering ecology. We investigated several cold-tolerance-related physiological traits at different time points during winter. Cold tolerance followed a latitudinal pattern; the northern species were more tolerant to short-term subzero temperatures than the invasive L. decemlineata. The other northern species, the knotgrass leaf beetle, Chrysolina polita, was found to tolerate internal freezing. Interestingly, the pattern for overwinter survival at 5°C was the opposite and higher in L. decemlineata than the northern species and could be related to behavioral differences between species in overwintering location selection and a potential physiological trade-off between tolerance to cold shock and to chronic cold exposure. Furthermore, while the northern species accumulated large amounts of different sugars and polyols with probable cryoprotectant functions, none were detected in L. decemlineata at high concentrations. This lack of cryoprotectant accumulation could explain the difference in cold tolerance between the species and also suggests that a lack of physiological capacity to tolerate low temperatures could slow further latitudinal range expansion of L. decemlineata.
The Royal Welsh Show: facilitating rural buzz

Abstract Agricultural shows are significant events for rural communities. Using the case study of the Royal Welsh Show, the largest event of its kind in Europe, this paper argues that agricultural shows can be seen as temporary knowledge clusters. By bringing together key rural actors, agricultural shows create temporary spaces for presentation and interaction between suppliers, producers and consumers, leading to distinct vertical and horizontal forms of knowledge exchange. Discussions take place between farmers, government and suppliers, creating trust and allowing for knowledge exchange to take place. At the same time, farmers can view and compare their stock and farming practices with that of other farmers, sharing best practice and allowing for new ideas to emerge and gain prominence in the agricultural industry. This interaction between different groups at agricultural shows creates a rural buzz, helping to maintain rural relations year round, eventually forming a community of practice.
Outdoor creational behaviours and preferences of Abuja residents, Nigeria

This study analyzed the recreational behaviours and preferences of residents of the federal capital city Abuja. The survey research design was adopted whereby structured questionnaires were used to elicit data from 400 randomly selected respondents through oral interviews. Descriptive statistical tools including averages, percentages, chi square test and bar charts were utilized in the analysis of the field data. Result of the investigation revealed that despite the heterogeneous nature of the sampled population of the central city, recreational activities occupy over 65% of the respondents’ leisure time, only 35% of the sampled respondents usually engage in non recreation activities. Again the result revealed six most preferred activities of recreation by majority (58%) of the sampled population which include watching soccer matches/other games in parks, playing soccer, taking beer/other drinks, bicycle riding, visiting museums and trekking. However, the result also indicates that the relative importance of these preferred recreational activities vary with age, gender, educational attainments and income levels of the residents. For effective recreation planning therefore, it has been recommended that the allocation of resources for recreational facilities in the city should not only reflect the preferences of the larger percent of the participants in these categories, but should also reflect that of the minorities in the same age, gender, education and income status. This will act as a guide towards adequacy of the facilities for the needs of all groups thereby averting underutilization of facilities or their over utilization by the citizens.
CONTEMPORARY ROLE OF INTERNAL AUDITING IN CORPORATE GOVERNANCE

The internal audit function has been constantly evolving in line with changes in the business environment. Contemporary challenges in the environment are closely related to risk and associated corporate governance issues. Consequently, shifting the internal audit function towards addressing corporate governance problems has called for greater independence of that function. In Slovenia, a new Companies Act was adopted in July 2015. In response to the need for a more independent internal audit function, it requires that decisions regarding the appointment and removal of the chief audit executive as well as their remuneration be approved by the supervisory board. The changes indicate that internal audit’s role in management-governance relationships has altered. The paper provides an overview of these changes, the trends leading to internal audit’s enhanced role in corporate governance, the expected benefits of internal audit’s organizational independence, and future challenges. Interviews were used to support the theoretical findings with observations from key stakeholders in Slovenia.
Technology Brokering and Breakthrough Invention

Interpreting technological invention as an evolutionary and recombinant search process, we study the effect of technology brokering, i.e. creating new inventions by combining formerly disconnected but familiar technology components, on the likelihood of inventing more useful and particularly breakthrough inventions. For evidence, we consider 26 years of the US patent record in biotechnology. We find that recombining more familiar components and creating new component combinations stimulate average usefulness and likelihood of breakthrough. In particular, interaction effects illustrate how recombining more familiar components continues to foster the creation of more useful and breakthrough inventions but only as long as the familiar components are recombined in unprecedented ways.
A Model of Organizational Integration, Implementation Effort, and Performance

The notion of integration is central to the understanding of organizations in general as well as of contemporary phenomena such as e-commerce, virtual organizations, virtual teams, and enterprise resource planning (ERP) implementation. Yet, the concept of integration is ill-defined in the literature, and the impact of achieving high levels of integration is not well understood. The present paper addresses these issues. Drawing on the literature of several fields, this paper proposes the concept oforganizational integration (OI), which is defined as the extent to which distinct and interdependent organizational components constitute a unified whole. Six types of OI are identified: two intraorganizational OI (internal-operational, internal-functional) and four interorganizational OI (external-operational-forward, external-operational-backward, external-operational-lateral, and external-functional). This paper then presents a model and develops 14 propositions to predict (1) the effort needed to implement different types of OI, (2) the impact different types of OI will have on organizational performance, and (3) how six factors (interdependence, barriers to OI, mechanisms for achieving OI, environmental turbulence, complexity reduction mechanisms, and organizational configurations) influence the relationship between OI types, implementation effort, and organizational performance. The OI framework and model are then used to develop 14 propositions for ERP implementation research and to explain the findings of recent research on integration.
Zarządzanie logistyczną obsługą klienta

W artykule przedstawiono role operatorow logistycznych w procesie obslugi rynku. Wzrost zainteresowania outsourcingiem w przedsiebiorstwach produkcyjnych przyczynil sie do wzrostu zapotrzebowania na uslugi logistyczne. Celem artykulu jest prezentacja zarządzania logistyczną obslugą klienta i kryterium wyboru, jakim kierują sie klienci indywidualni przy dostawie produktow przez operatora logistycznego. Metody zastosowane to analiza literatury i metoda pośrednich pomiarow sondazowych z zastosowaniem techniki kwestionariusza ankiety. W procesie obslugi klienta wykorzystano koncepcje CRM w celu tworzenia wartości dla nabywcy produktu. Wskazano czynniki decydujące o wyborze operatora logistycznego, a nastepnie potwierdzono przyjetą teze badaniami. Najwazniejszą dla ankietowanych jest czas dostaw – od momentu zlozenie zamowienia do momentu otrzymania przesylki.
Bile acids and nonalcoholic fatty liver disease: An intriguing relationship

than individuals with nonalcoholic steatohepatitis (NASH). The patients with DIOS were selected on the basis of serum ferritin levels >400 lg/L, hepatic iron concentration assessed by magnetic resonance imaging >50 lmol/g, and body mass index >27 kg/m. Accordingly, advanced iron overload is required for a diagnosis of DIOS. In contrast, in our study, only four of the patients with NASH meet these criteria. The remainder of the patients with NASH in our study do not meet their criteria of DIOS. In general, mild or moderate degrees of hepatic iron accumulation are common in patients with NASH. Because we did not observe increased duodenal absorption in our four patients with NASH and DIOS, we agree that iron absorption was lower in patients with DIOS than in lean and overweight controls without iron overload. Overall, we suggest that patients with DIOS exhibit a different pattern of iron absorption from those with NASH.