Miracle-dz/UniFAR-FTUs huggingface dataset:
Taste Stimuli: A Behavioral Categorization

The selective patterns of generalization to various chemicals, obtained in rats after radiation-induced gustatory-avoidance conditioning against single chemicals, were used to evaluate qualitative similarities among taste stimuli. DL-Alanine, glycine, and sodium saccharin were classed together, but not with D-glucose or potassium chloride. Groupings such as these may serve as a basis for determining the dimensions along which taste quality is represented.
Statin therapy in the heart and estrogen/progestin replacement study.

AIM Limited data exists to guide secondary prevention in postmenopausal women with coronary heart disease (CHD). Treatment with HMG-CoA reductase inhibitors (statins) is likely to be beneficial for these patients. Yet, clinical trial results are conflicting. Moreover, significant interactions may exist between statins and hormone replacement therapy (HRT) that may complicate this approach. METHODS In a post hoc analysis of the HERS trial, patients who were taking a statin were compared to those who were not. Subjects were randomized to HRT or placebo. Statin therapy was not controlled by the trial investigators, but may have been prescribed by the patients' primary physicians. Use of statins was monitored throughout the trial. The primary outcome was the composite of myocardial infarction and death resulting from CHD, with all-cause mortality and venous thromboembolism (VTE) as secondary outcome measures. RESULTS At baseline, 1004 subjects were taking a statin, with 1234 subjects randomized to receive HRT, and 1237 to receive placebo. Baseline statin use was associated with lower rates of the primary outcome (MI or fatal CHD, RH=0.78, 95% CI 0.61 to 0.99, p=0.044), and all-cause mortality (RH=0.74, 95% CI 0.56 to 0.99, p=0.04). Statin therapy was associated with a reduced incidence of VTE in both the HRT group and the placebo arm. The negative effect of HRT on the primary outcome seen in the 1st year of treatment was much reduced among baseline statin users and was no longer statistically significant (RH=1.34, 95% CI 0.63 to 2.86, p=0.45). CONCLUSION Data from HERS supports the use of statins for secondary prevention in postmenopausal women with a history of cardiovascular disease. Statins may attenuate the increased cardiovascular risk of hormone replacement therapy.
Colleagues helping each other to publish in medical sciences: Iranian field specialists' convenience editing strategies

This article reports a study into 60 research articles (RAs) authored by Iranian medical researchers and published in high‐quality international English journals. It investigated how academic professionals in medical sciences implement peer convenience editing (CE) to improve articles and make them suitable for publication. The research identified nine editing interventions that were categorized as micro‐ or macro‐editing strategies. The findings indicated that the most frequently used strategies are micro‐strategies of substitution, addition, and mechanical alteration. The study also found that the abstract received the majority of editorial changes (mostly micro), followed by the introduction and then the discussion sections. The findings may help authors and institutions identify which sections and which types of editorial interventions are most likely to be required to ensure that RAs are optimized for publishing in international journals.
Clinical practice. Streptococcal pharyngitis.

Copyright © 2011 Massachusetts Medical Society. A 10-year-old girl presents with a sore throat and fever that has lasted for 1 day. She appears flushed and moderately ill. Physical examination reveals a temperature of 39°C, tender bilateral anterior cervical lymph nodes that are 1 to 2 cm in the greatest dimension, and erythema and whitish-yellow exudate over enlarged tonsils and the posterior pharynx. A rapid antigen-detection test from a throat-swab specimen is positive for group A streptococcus. How should the patient be evaluated and treated?
Risk of parathyroid adenomas in patients with thyrotoxicosis exposed to radioactive iodine

External ionizing radiation is a risk factor for primary hyperparathyroidism. Whether exposure to radioactive iodine contributes to the risk of primary hyperparathyroidism is unknown. Patients with thyrotoxicosis are often treated with radioactive iodine and its accumulation in the thyroid gland exposes the adjacent parathyroid glands to radioactivity. Six thousand and eighty two patients with thyrotoxicosis (ICD-9 = 242) were identified from medical records. In a randomly selected subcohort we assessed the frequency of treatment with radioactive iodine to be 86%. The number of patient-years at risk was 77 118. Patients with parathyroid adenomas (ICD-9 = 195.1) were recruited from the Swedish Cancer Registry. Eleven patients with parathyroid adenomas following the diagnosis of thyrotoxicosis were identified. The standard incidence ratio (SIR) compared to the reference population of ∼900 000 was 1.14 (95% CI 0.57–2.03). The median age at exposure was 59 years and the latency period between diagnosis of thyrotoxicosis and parathyroid adenoma was 7.4 years (range <1–19 years). This study does not indicate that patients with thyrotoxicosis treated with radioactive iodine in adult age have increased risk of developing parathyroid adenoma.
Towards Practical k-Anonymization: Correlation-based Construction of Generalization Hierarchy

The privacy of individuals included in the datasets must be preserved when sensitive datasets are published. Anonymization algorithms such as k-anonymization have been proposed in order to reduce the risk of individuals in the dataset being identified. k-anonymization is the most common technique of modifying attribute values in a dataset until at least k identical records are generated. There are many algorithms that can be used to achieve k-anonymity. However, existing algorithms have the problem of information loss due to a tradeoff between data quality and anonymity. In this paper, we propose a novel method of constructing a generalization hierarchy for k anonymization algorithms. Our method analyses the correlation between attributes and generates an optimal hierarchy according to the correlation. The effect of the proposed scheme has been verified using the actual data: the average of k of the datasets is 83:14, and it is around 1=3 of the value obtained by conventional methods.
Impact of Dialysate Calcium Concentration on Clinical Outcomes in Incident Hemodialysis Patients

AbstractThe association between dialysate calcium (DCa) concentration and mortality in hemodialysis (HD) patients is controversial. In this study, we evaluated the impact of DCa concentration on mortality in incident HD patient.Incident HD patients were selected from the Clinical Research Center registry—a prospective cohort study on dialysis patients in Korea. Patients were categorized into 3 groups according to the prescribed DCa concentration at the time of enrollment. High DCa was defined as a concentration of 3.5 mEq/L, mid-DCa as 3.0 mEq/L, and low DCa as 2.5 to 2.6 mEq/L. The primary outcome was all-cause mortality and secondary outcomes were cardiovascular or infection-related hospitalization.A total of 1182 patients with incident HD were included. The number of patients in each group was 182 (15.4%) in high DCa group, 701 (59.3%) in the mid-DCa group, and 299 (25.3%) in the low DCa group. The median follow-up period was 16 months. The high DCa group had a significantly higher risk of all-cause mortality compared with the mid-DCa group (hazard ratio [HR] 2.23, 95% confidence interval [CI] 1.28–3.90, P = 0.005) and the low DCa group (HR 3.67, 95% CI 1.78–7.55, P < 0.001) after adjustment for clinical variables. The high DCa group was associated with higher risk of cardiovascular and infection-related hospitalization compared with the low DCa group (HR 3.25, 95% CI 1.53–6.89, P = 0.002; and HR 2.77, 95% CI 1.29–5.94, P = 0.009, respectively). Of these 1182 patients, 163 patients from each group were matched by propensity scores. In the propensity score matched analysis, the high DCa group had a significantly higher risk of all-cause mortality compared with the mid-DCa group (HR 2.52, 95% CI 1.04–6.07, P = 0.04) and the low DCa group (HR 4.25, 95% CI 1.64–11.03, P = 0.003) after adjustment for clinical variables.Our data showed that HD using a high DCa was a significant risk factor for all-cause mortality and cardiovascular or infection-related hospitalization in incident HD patients.
Environmental pesticide exposure as a risk factor for Alzheimer's disease: a case-control study.

The aim of this study was to evaluate the influence of pesticide exposure on the development of Alzheimer's disease (AD), taking into account the potentially confounding factors (genetic, occupational exposure, and sociodemographic). The 1924 study participants (>70 years old) were randomly selected in the Saguenay-Lac Saint-Jean region (Quebec, Canada). The AD diagnosis was established in three steps according to recognized criteria. Sixty-eight cases were paired with a nondemented control for age (+/-2 years) and sex. Structured questionnaires addressed to subjects and proxy respondents allowed a description of the sociodemographic characteristics, lifestyle characteristics, and residential, occupational, familial, and medical histories. Assessment of environmental exposure to pesticides was based on residential histories and the agriculture census histories of Statistics Canada (1971-1991) for herbicide and insecticide spraying in the area. Statistical analyses were performed with a logistic regression, adjusting for potential confounding factors. The results failed to show a significant risk of AD with an exposure to herbicides, insecticides, and pesticides. However, future investigations are needed to establish more precisely the identification, measurement, mobility, and bioavailability of neurotoxic pesticide residues in relation to AD.
Online counselling for eating disorders: Reaching an underserved population?

Background A substantial proportion of individuals suffering from eating disorders (ED) seek help late and many never access treatment. Internet-based services may have the potential to reach these underserved individuals by providing low-intense support and facilitating access to regular healthcare. Method Two hundred and thirty-eight individuals who used a counselling service for ED via email and/or moderated forums were surveyed. Acceptance of the service, users' satisfaction, utilization of other services, and attitudes towards Internet-based interventions were assessed. Results Participants reported substantial ED symptoms (67.4% reported bingeing, 42.2% self-induced vomiting, and 18.0% a body mass index below 17.5). Both forum and email counselling were rated very positively. More than half of the participants (57.3%) stated that this was the first time they ever accessed professional help. Half of these reported that they engaged in additional services after registering for the online program and most of them stated that they would have not done so without the online service. Discussion The Internet-based service proved well-accepted in the target group. It reaches a substantial percentage of individuals with ED-related impairment that would have stayed without any professional support otherwise. The service also facilitated access to the regular healthcare system for a subgroup of participants.
Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore*

Background: The cytoplasmic entrance to the CFTR channel pore is not defined. Results: Functionally important positively charged amino acid side chains attract Cl− to the cytoplasmic entrance to the pore. Conclusion: A lateral portal leads to the inner mouth of the pore. Significance: This work defines the last unknown region of the anion permeation pathway. As an ion channel, the cystic fibrosis transmembrane conductance regulator must form a continuous pathway for the movement of Cl− and other anions between the cytoplasm and the extracellular solution. Both the structure and the function of the membrane-spanning part of this pathway are well defined. In contrast, the structure of the pathway that connects the cytoplasm to the membrane-spanning regions is unknown, and functional roles for different parts of the protein forming this pathway have not been described. We used patch clamp recording and substituted cysteine accessibility mutagenesis to identify positively charged amino acid side chains that attract cytoplasmic Cl− ions to the inner mouth of the pore. Our results indicate that the side chains of Lys-190, Arg-248, Arg-303, Lys-370, Lys-1041, and Arg-1048, located in different intracellular loops of the protein, play important roles in the electrostatic attraction of Cl− ions. Mutation and covalent modification of these residues have charge-dependent effects on the rate of Cl− permeation, demonstrating their functional role in maximization of Cl− flux. Other nearby positively charged side chains were not involved in electrostatic interactions with Cl−. The location of these Cl−-attractive residues suggests that cytoplasmic Cl− ions enter the pore via a lateral portal located between the cytoplasmic extensions to the fourth and sixth transmembrane helices; a secondary, functionally less relevant portal might exist between the extensions to the 10th and 12th transmembrane helices. These results define the cytoplasmic mouth of the pore and show how it attracts Cl− ions from the cytoplasm.
Global visual processing in macaques studied using Kanizsa illusory shapes

Abstract The ability to extract form information from a visual scene, for object recognition or figure–ground segregation, is a fundamental visual system function. Many studies of nonhuman primates have addressed the neural mechanisms involved in global form processing, but few have sought to demonstrate this ability behaviorally. In this study, we probed global visual processing in macaque monkeys (Macaca nemestrina) using classical Kanizsa illusory shapes as an assay of global form perception. We trained three monkeys on a “similarity match-to-sample” form discrimination task, first with complete forms embedded in fields of noncontour-inducing “pacman” elements. We then tested them with classic Kanizsa illusory shapes embedded in fields of randomly oriented elements. Two of the three subjects reached our criterion performance level of 80% correct or better on four of five illusory test conditions, demonstrating clear evidence of Kanizsa illusory form perception; the third subject mastered three of five conditions. Performance limits for illusory form discrimination were obtained by manipulating support ratio and by measuring threshold for discriminating “fat” and “thin” illusory squares. Our results indicate that macaque monkeys are capable of global form processing similarly to humans and that the perceptual mechanisms for “filling-in” contour gaps exist in macaques as they do in humans.
Early Detection of Psychotic Disorders in Adolescents: Specificity of Basic Symptoms in Psychiatric Patient Samples

Based on the results of adult studies that have shown a subgroup of basic symptoms to have a predictive value for later schizophrenic disorder, a cross-sectional study on 36 schizophrenic and 75 nonschizophrenic adolescent psychiatric inpatients was performed to elucidate the specificity of prodromal signs in early age groups. The occurrence of any single basic symptom does not show schizophrenic specificity in adolescents, but the number of basic symptoms in the categories of the Bonn Scale for the Assessment of Basic Symptoms is increased in schizophrenic patients compared with subjects with other diagnoses. The interrelation between minus symptoms and cognitive symptoms exerts a higher amount of cognitive disturbances given a certain level of irritation in schizophrenic adolescents. With the help of odds ratios, the seven most discriminating cognitive items could be elucidated including perception, information processing and action tendency.
Fatal Occupational Injuries in the South Delhi Construction Industry: A retrospective study

One hundred and forty-five unselected autopsy cases of construction site accidents received from South Delhi were studied during the period from 1996-2002. Data for the study was gathered from autopsy reports and hospital records. The cases represented approximately 1.61% of all autopsy cases received from South Delhi at the All India Institute of Medical Sciences, New Delhi (India). Data was analysed with regard to the age and sex of the victim, the part of the body involved, the manner of accident, the cause of death and the pattern of injuries in different body regions. Death occurred at the scene of the fatal event in thirty-four cases; forty-three cases were dead on arrival at the hospital; sixty-eight cases died after being admitted to the hospital. Ethanol was detected in the blood of 16% of the cases.
Interactions between Neurogranin and Calmodulin in Vivo *

Neurogranin is a neural-specific, calmodulin (CaM)-binding protein that is phosphorylated by protein kinase C (PKC) within its IQ domain at serine 36. Since CaM binds to neurogranin through the IQ domain, PKC phosphorylation and CaM binding are mutually exclusive. Consequently, we hypothesize that neurogranin may function to concentrate CaM at specific sites in neurons and release free CaM in response to increased Ca2+ and PKC activation. However, it has not been established that neurogranin interacts with CaM in vivo. In this study, we examined this question using yeast two-hybrid methodology. We also searched for additional proteins that might interact with neurogranin by screening brain cDNA libraries. Our data illustrate that CaM binds to neurogranin in vivo and that CaM is the only neurogranin-interacting protein isolated from brain cDNA libraries. Single amino acid mutagenesis indicated that residues within the IQ domain are important for CaM binding to neurogranin in vivo. The Ile-33 → Gln point mutant completely inhibited and Arg-38 → Gln and Ser-36 → Asp point mutants reduced neurogranin/CaM interactions. These data demonstrate that CaM is the major protein that interacts with neurogranin in vivo and support the hypothesis that phosphorylation of neurogranin at Ser-36 regulates its binding to CaM.
IL-12 Inhibition of Endothelial Cell Functions and Angiogenesis Depends on Lymphocyte-Endothelial Cell Cross-Talk1

In vivo IL-12-dependent tumor inhibition rests on the ability of IL-12 to activate a CD8-mediated cytotoxicity, inhibit angiogenesis, and cause vascular injury. Although in vivo studies have shown that such inhibition stems from complex interactions of immune cells and the production of IFN-γ and other downstream angiostatic chemokines, the mechanisms involved are still poorly defined. Here we show that IL-12 activates an anti-angiogenic program in Con A-activated mouse spleen cells (activated spc) or human PBMC (activated PBMC). The soluble factors they release in its presence arrest the cycle of endothelial cells (EC), inhibit in vitro angiogenesis, negatively modulate the production of matrix metalloproteinase-9, and the ability of EC to adhere to vitronectin and up-regulate ICAM-1 and VCAM-1 expression. These effects do not require direct cell-cell contact, yet result from continuous interaction between activated lymphoid cells and EC. We used neutralizing Abs to show that the IFN-inducible protein-10 and monokine-induced by IFN-γ chemokines are pivotal in inducing these effects. Experiments with nu/nu mice, nonobese diabetic-SCID mice, or activated spc enriched in specific cell subpopulations demonstrated that CD4+, CD8+, and NK cells are all needed to mediate the full anti-angiogenetic effect of IL-12.
Beyond the lymphocyte predominant cell: CD4+CD8+ T-cells in nodular lymphocyte predominant Hodgkin lymphoma

Hodgkin lymphomas are characterised by the presence of rare malignant cells in a background of non-neoplastic inflammatory cells. Flow cytometric analysis of involved tissues is generally not thought to be useful in establishing the diagnosis, because of the small number of neoplastic cells present. However, two recent studies describing a CD4+CD8+ (double-positive) T-cell population in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) suggest that flow cytometry could play a role in the diagnosis of this Hodgkin lymphoma subtype. In addition, awareness of this unusual T-cell population is important in avoiding a misdiagnosis of a T-cell neoplasm. Although the function of CD4+CD8+ T-cells in NLPHL is not known, studies of phenotypically similar cells in other settings point to a reactive or regulatory role. CD4+CD8+ T-cells have also been identified in the benign entity progressive transformation of germinal centres (PTGC), suggesting a possible relationship between NLPHL and PTGC.
Radiation Heat Transfer and Reaction Chemistry Models for Risk Assessment Compatible Fire Simulations

Risk assessment studies for hazardous material packages require fire response prediction tools that are both accurate and rapid. This article describes the theoretically based, semiempirical reaction chemistry and radiation heat transfer models for large, optically dense pool fires incorporated in the ISIS-3D CFD software. The chemistry model employs four separate reactions (two produce radiating soot). The heat transfer model divides the computational domain into the diffusely radiative fire and its nonparticipating environment. ISIS-3D simulations are performed on a 6-m square JP8 pool fire experiment in which the soot temperature and volume fraction are measured. The reaction rate and soot formation parameters of the chemistry model are determined based on a comparison of the simulation with the measured data. Simulations are then performed on an experiment that measures the temperature of a pipe calorimeter suspended over the leeside of a 19-m-diameter JP8 fuel pool fire with a 9.5 m/s crosswind. The .
Adaptive control of arbitrary nonlinear inputs with feedforward compensation

This paper deals with Model Reference Adaptive Control (MRAC) with arbitrary bounded nonlinear inputs. A new analysis and design method is proposed. The main technique we used is feedforward compensation, with it the input nonlinearities may be partly cancelled by the feedforward controller and the closed-loop can be locally stabilized. Only standard assumptions of robust adaptive control is needed. We show that the modified scheme has the same stability and robustness properties as the standard one, but the performance are improved.