Miracle-dz/UniFAR-FTUs huggingface dataset:
3D‐Printed, All‐in‐One Evaporator for High‐Efficiency Solar Steam Generation under 1 Sun Illumination

Using solar energy to generate steam is a clean and sustainable approach to addressing the issue of water shortage. The current challenge for solar steam generation is to develop easy‐to‐manufacture and scalable methods which can convert solar irradiation into exploitable thermal energy with high efficiency. Although various material and structure designs have been reported, high efficiency in solar steam generation usually can be achieved only at concentrated solar illumination. For the first time, 3D printing to construct an all‐in‐one evaporator with a concave structure for high‐efficiency solar steam generation under 1 sun illumination is used. The solar‐steam‐generation device has a high porosity (97.3%) and efficient broadband solar absorption (>97%). The 3D‐printed porous evaporator with intrinsic low thermal conductivity enables heat localization and effectively alleviates thermal dissipation to the bulk water. As a result, the 3D‐printed evaporator has a high solar steam efficiency of 85.6% under 1 sun illumination (1 kW m−2), which is among the best compared with other reported evaporators. The all‐in‐one structure design using the advanced 3D printing fabrication technique offers a new approach to solar energy harvesting for high‐efficiency steam generation.
Do Mortgage Subsidies Help or Hurt Borrowers

Mortgage subsidies affect homeownership costs by reducing effective mortgage rates and increasing house prices. I show analytically the role of mortgage subsidies in determining house price changes, economic incidence, and efficiency costs using a theoretical framework for applied welfare analysis. I derive simple expressions for these effects, as functions of reduced-form sufficient statistics, which I use to measure the effects from eliminating mortgage deductions. My main results characterize the distributional impact of mortgage subsidies among buyers and owners and how house price responses attenuate efficiency losses. My results provide broader methodological insights into the welfare analysis of credit policies.
Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission.

BACKGROUND Effective strategies are urgently needed to reduce mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) through breast-feeding in resource-limited settings. METHODS Women with HIV-1 infection who were breast-feeding infants were enrolled in a randomized, phase 3 trial in Blantyre, Malawi. At birth, the infants were randomly assigned to one of three regimens: single-dose nevirapine plus 1 week of zidovudine (control regimen) or the control regimen plus daily extended prophylaxis either with nevirapine (extended nevirapine) or with nevirapine plus zidovudine (extended dual prophylaxis) until the age of 14 weeks. Using Kaplan-Meier analyses, we assessed the risk of HIV-1 infection among infants who were HIV-1-negative on DNA polymerase-chain-reaction assay at birth. RESULTS Among 3016 infants in the study, the control group had consistently higher rates of HIV-1 infection from the age of 6 weeks through 18 months. At 9 months, the estimated rate of HIV-1 infection (the primary end point) was 10.6% in the control group, as compared with 5.2% in the extended-nevirapine group (P<0.001) and 6.4% in the extended-dual-prophylaxis group (P=0.002). There were no significant differences between the two extended-prophylaxis groups. The frequency of breast-feeding did not differ significantly among the study groups. Infants receiving extended dual prophylaxis had a significant increase in the number of adverse events (primarily neutropenia) that were deemed to be possibly related to a study drug. CONCLUSIONS Extended prophylaxis with nevirapine or with nevirapine and zidovudine for the first 14 weeks of life significantly reduced postnatal HIV-1 infection in 9-month-old infants. (ClinicalTrials.gov number, NCT00115648.)
Dermal‐Epidermal Cross‐Talk: Differential Interactions With Microvascular Endothelial Cells

The biological importance of circulatory blood supply and angiogenesis for hair growth is now well recognized, but the their regulatory mechanisms require more mechanistic investigation. In vitro cocultures and tricultures can be successfully employed to greatly improve our knowledge on paracrine crosstalk between cell types that populate the dermal‐epidermal interface and cutaneous vasculature. Here we report that human dermal fibroblasts (NHDF) promote viability and proliferation of microvascular endothelial cells (HMVEC), while HMVEC are not mitogenic for NHDF. In triculture setup, conditioned media (CM) obtained by cocultures (HMVEC/NHDF or HMVEC/follicle fibroblasts) differently modulate growth and proliferation of keratinocytes and alter the expression of metabolic and pro‐inflammatory markers. In conclusion, tricultures were successfully employed to characterize in vitro dermal‐epithelial and endothelial interactions and could integrate ex vivo and in vivo approaches by the use of high‐throughput and standardized protocols in controlled conditions. J. Cell. Physiol. 232: 897–903, 2017. © 2016 Wiley Periodicals, Inc.
Early improvement as a predictor of treatment response and remission in patients with schizophrenia: A pooled, post-hoc analysis from the asenapine development program

Objective: The purpose of this study was to assess whether early symptom improvement predicts later treatment outcome in patients with schizophrenia. Methods: Data were pooled from intent-to-treat (ITT) populations of three six-week randomized controlled studies with fixed doses of asenapine (ASE; n=470), olanzapine (OLA; n=95), risperidone (RIS; n=56), haloperidol (HAL; n=112), or placebo (PLA; n=275). Early improvement was defined as a 20% reduction of Positive and Negative Syndrome Scale (PANSS) total score at week 2, compared to baseline (primary criterion). Treatment outcome at week 6 was defined as response (PANSS: ≥50% score reduction) or remission (PANSS item score ≤3 on selected items at week 6). Odds ratios (ORs) and predictive performance statistics were calculated. Results: Statistically significant associations between early improvement (at week 2) and treatment outcome (at week 6) were observed for all treatment groups except OLA; as evidenced by increased ORs for response. Analysis of associations between early improvement and remission, as defined by Andreasen et al. (2005), revealed a statistically significant relationship for ASE and PLA-treated patients only. Predictive performance statistics revealed higher negative predictive value (NPV) and sensitivity rates, and comparably lower positive predictive value (PPV) and specificity rates across treatment groups for both response and remission. Conclusion: It is suggested that absence of improvement within two weeks of treatment may predict the unlikely success of subsequent pharmacological intervention.
Brain MRI volumetry in a single patient with mild traumatic brain injury

This letter to the editor describes the case of a 42 year old man with mild traumatic brain injury and multiple neuropsychiatric symptoms which persisted for a few years after the injury. Initial CT scans and MRI scans of the brain showed no signs of atrophy. Brain volume was measured using NeuroQuant®, an FDA-approved, commercially available software method. Volumetric cross-sectional (one point in time) analysis also showed no atrophy. However, volumetric longitudinal (two points in time) analysis showed progressive atrophy in several brain regions. This case illustrated in a single patient the principle discovered in multiple previous group studies, namely that the longitudinal design is more powerful than the cross-sectional design for finding atrophy in patients with traumatic brain injury.
Evaluation of CytoDiff™ on cord blood WBC differential

An umbilical cord blood bank was recently opened in our institution as an alternative source of hematopoietic stem cells. Before inclusion of a cord blood in an international register, a WBC with differential is requested, among others. Currently, the reference method is the microscopic manual count, and we sought to evaluate the routine flow cytometric method (CytoDiff™) as an alternative.
GITR ligand-mediated local expansion of regulatory T cells and immune privilege of corneal allografts.

PURPOSE The pathway between the glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) and GITR ligand (GITRL) has been shown to control the function of regulatory T cells (Treg). The present study was conducted to investigate the role of this pathway and Treg in establishing immune privilege status for corneal allografts. METHODS Corneas of C57BL/6 mice were orthotopically transplanted into the eyes of BALB/c mice, and graft survival was assessed. A separate set of BALB/c mice received an anterior chamber injection of C57BL/6 splenocytes, and induction of allo-specific anterior chamber-associated immune deviation was assessed. Recipients were intraperitoneally administrated anti-GITRL, anti-CD25 monoclonal antibodies (mAb), or control immunoglobulin (IgG). Expressions of GITRL, GITR, and Foxp3 in the allografts were assessed. In vitro, cornea pretreated with anti-GITRL mAb or control IgG was incubated with T cells, and destruction of corneal endothelial cells and the population of Foxp3(+)CD25(+)CD4(+) T cells were assessed. RESULTS GITRL was expressed constitutively in the cornea and iris-ciliary body. GITRL-expressing allografts were infiltrated with Foxp3+GITR+CD25+CD4(+) T cells. Blockade of GITRL did not affect allo-specific ACAID but led to infiltration of Foxp3(-)CD4(+) T cells and allograft rejection. Depletion of CD25+CD4(+) Treg also accelerated allograft rejection. Destruction of corneal endothelial cells by T cells was significantly enhanced in GITRL-blocked cornea compared with control cornea. Foxp3+CD25+CD4(+) T cells were increased after incubation with GITRL-expressing cornea, but not with GITRL-blocked cornea. CONCLUSIONS Presence of Foxp3+CD25+CD4(+) Treg in the allograft is necessary for allograft survival. GITRL-dependent expansion of Treg within the cornea is one mechanism underlying immune privilege in corneal allografts.
Design of an electromagnetic-transducer energy harvester

This paper presents the design and the manufacturing of an electromagnetic- transducer energy harvester. The design considers the coupling between the mechanical vibrating behaviour, generated by a base excitation, and the electromagnetic conversion of energy, which is aimed to produce the voltage across a load resistance. The design is based on some constraints, which are related to the characteristics of the shaker and aimed to obtain the best performance of the device. Current tests show the presence friction at low input levels, which is associated with the gearbox. The output voltage and the harvested power of the device are studied experimentally for different values of load. By increasing the value of the load from zero (short circuit) to high values (open circuit) the swing angle increases, while the harvested power presents a peak associated with the electrical damping. Also, harmonic tests are run at resonance for different levels of excitation to demonstrate the effect of the nonlinearity on the voltage and the harvested power. A nonlinear load resistance, is then introduced as part of future work. The aim is to try to increase the harvested power with respect to the linear load, at low level of excitation.
Mutational Analysis of K-ras Segregates Ovarian Serous Carcinomas into Two Types: Invasive MPSC (Low-grade Tumor) and Conventional Serous Carcinoma (High-grade Tumor)

We previously proposed a dualistic model for ovarian serous carcinogenesis. One pathway involves the stepwise development of invasive micropapillary serous carcinoma (MPSC) from serous borderline tumor (atypical proliferative serous tumor) to noninvasive and then invasive MPSC. The carcinomas that develop in this fashion are characterized by low-grade nuclei and frequent K-ras mutations. They generally pursue an indolent course. In the other pathway conventional serous carcinoma (CSC) develops de novo from the ovarian surface epithelium without what appears to be intermediate stages. These tumors display high-grade nuclei, wild-type K-ras, and are very aggressive. Some of these CSCs display micropapillary architecture and simulate invasive MPSCs. This raises the possibility that these CSCs develop from an invasive MPSC. To address this question we reviewed 31 moderately and poorly differentiated CSCs and identified 7 with morphological features of invasive MPSC. These seven tumors exhibited micropapillary architecture in at least 25% of the tumor but contained high-grade nuclei. The 31 tumors were assessed for K-ras mutations using digital polymerase chain reaction-based analysis. Despite their micropapillary architecture, all 7 CSCs with micropapillary features contained wild-type K-ras as did the other 24 pure CSCs. The results indicate that CSCs with micropapillary features are not derived from invasive MPSCs. The molecular findings also support the view that ovarian serous carcinomas should be graded as low- and high-grade tumors.
OPN04-4: Space-Time Coded Modulation and Detection in Coherent Freespace Optical Communications

This paper presents the use of space-time coding techniques to fully exploit polarization diversity in coherent optical systems without the need for polarization tracking. Our approach is analogous to a situation of two transmit antennas and two receive antennas in a wireless communication system. Utilizing the two polarizations intelligently, the highly effective technique of orthogonal space-time block coding is applied to combat polarization uncertainty and signal losses due to free- space non-idealities. The use of space-time block coding and differential space-time block coding are modeled and tested successfully. Significant performance gain is demonstrated by our new coherent optical multiple-input multiple-output (COMIMO) system over many traditional coherent optical communication techniques.
Serum leptin and plasma ghrelin concentrations in patients with chronic hepatitis C virus with steatosis: Their effect on the response to antiviral therapy

Objective: To assess serum leptin and plasma ghrelin concentrations and their roles in the response to antiviral therapy in patients with chronic hepatitis C virus (HCV) and steatosis Methods: This study was conducted on 50 chronic HCV patients with steatosis, and 50 healthy participants of matched age as a control group. Serum leptin, plasma ghrelin, serum HCV-RNA concentrations and insulin resistance were measured in patients with HCV before and after antiviral treatment using Peg-IFN plus ribavirin for 48 weeks. Results: We showed high insulin resistance and serum leptin level, while. low plasma ghrelin level at base line in patients with HCV compared to healthy controls. Leptin level increase (P=0.023) while ghrelin levels tend to decrease (P=0.004) as the grade of steatosis worsens. Sustained virological response ( SVR) as achieved in 28 patients (56%) and was associated with a lower grade of liver steatosis (P=0.013), milder fibrosis (P=0.002), low value of insulin resistance (P=0.001), lower leptin levels (P=0.005) and higher ghrelin levels (P=0.001). Conclusions: Decreased serum leptin whereas Increased plasma ghrelin before treatment may predict Sustained virological response. Ghrelin exerts antifibrotic effects in the liver and may represent a novel antifibrotic therapy.
An Improved Soft Dielectric for a Highly Sensitive Capacitive Tactile Sensor

This paper presents a novel capacitive tactile sensor that is capable of making highly accurate measurements at low pressure levels, while also being functional within a wide range of pressure. Many researchers have concentrated on sensing applied pressure using methods, such as piezoresistive, optoelectronics, and piezoelectric technologies; but a very popular approach in recent years uses capacitance-based sensing. However, most capacitive sensors, due to the properties of their dielectrics, remain limited by hysteresis and narrow ranges of sensitivity. Our sensor overcomes these restrictions because of the improved soft dielectric that we have constructed. This dielectric features a double-stage microstructure, allowing it to be very sensitive to low pressure while still able to measure a wide range of pressure. The silicone used to construct the dielectric is doped with high permittivity nanoparticles to enhance the response of the sensor. Furthermore, considering the complexity of the dielectric's construction, our fabrication process is relatively simple. In this paper, we describe the design and fabrication of this dielectric and present the results of our sensor's performance.
Cell-mediated and humoral immune responses to herpes simplex virus and cytomegalovirus in renal transplant patients

Cell-mediated immunity to herpes simplex virus and cytomegalovirus, using the lymphocyte transformation test and interferon induction in lymphocytes, was studied in 59 patients from 1 day to 7 years after allotransplantation and compared with the results in normal subjects. Both parameters were permanently depressed with regard to cytomegalovirus. With herpes simplex virus, interferon production was also permanently depressed, whereas the transformation reaction was normal during the first year after transplantation and only slightly depressed in patients more than 1 year after transplantation. In 6 patients the above-mentioned assays and the complement fixation reaction were performed serially and related to the clinical signs of herpes simplex virus and cytomegalovirus infection. The relationship between depression of the transformation reaction and interferon production in lymphocytes and the occurrence of clinically evident herpes simplex virus and cytomegalovirus infections was, however, equivocal. The humoral immune response to herpes simplex virus was measured by the complement fixation test and the more sensitive antibody-dependent, cell-mediated cytotoxicity reaction, and a good correlation was found between these two tests, although only a few persons were found to be negative in the antibody-dependent, cell-mediated cytotoxicity reaction. The suggestion is made that only a few adults are "true" herpes simplex virus seronegative.
Pitfalls in the immunophenotyping of leukaemia and leukaemic lymphomas: survey of 9 years of quality control in The Netherlands

During the last decade, biannual quality controls were performed in The Netherlands focusing on the immunophenotyping of leukaemic haematological malignancies. All results on 48 specimens obtained by 18–34 laboratories were analysed. The interlaboratory variability and percentages of discordant results from 30 markers were measured by assessing false positive or negative (cut‐off 10%) results in comparison with median results of the group. The quality of the immunophenotypic diagnoses obtained from the interpretation of these markers in relation to clinical data was evaluated by scoring them as ‘correct’, ‘minor fault’, ‘major fault’, ‘not based upon the markers used’, and ‘no diagnosis’. CD3, CD8, CD19, CD61 and Smλ had the lowest percentage discordancy (sum of total negative and positive discordant values 5–7.5% of assays); CD13, CD15, cyCD22, CD33 and TdT scored worst with 14–20% cumulative discordancy. The analysis of each diagnosis yielded 78% acceptable immunophenotypic conclusions (correct 54% and minor fault 24%). It appeared that the major faults in immunophenotyping were caused by suboptimal antibody selection and erroneous interpretation of the results obtained, rather than by technical errors. Large differences per diagnostic category were observed, with the best scores for mature B‐cell leukaemias, AMLs and common‐ALL, and the poorest scores for T‐cell malignancies which were correctly diagnosed in only 24–60% of specimens. Mature T‐NHL and T‐PLL were mistakenly diagnosed as T‐ALL by 40% of the centres. Misinterpretation of TdT immunofluorescence or omitting this marker contributed significantly to these wrong diagnoses. A median of 4% of immunophenotypic diagnoses were not based on a correct panel of antibodies, but upon the morphology of the accompanying blood smear, and was often flawed by overinterpretation.
THE STELLAR MASS CONTENT OF SUBMILLIMETER-SELECTED GALAXIES

We present a new study of stellar mass in a sample of ∼70 submillimeter-selected galaxies (SMGs) with accurate spectroscopic redshifts. We fit combinations of stellar population synthesis models and power laws to the galaxies' observed-frame optical through mid-IR spectral energy distributions (SEDs) to separate stellar emission from non-stellar near-IR continuum. The availability of spectroscopic redshifts significantly enhances our ability to determine unambiguously not only the mass and luminosity of SMGs, but also the presence and contribution of non-stellar emission to their SEDs. By separating the stellar emission from the non-stellar near-IR continuum, we find that ∼50% of our sample have non-stellar contributions of less than 10% in rest-frame H band and ∼10% of our sample have non-stellar contributions greater than 50%. We find that the K-band luminosity of the non-stellar continuum emission is correlated with hard X-ray luminosity, indicating an active galactic nucleus (AGN) origin of the emission. Upon subtracting this AGN-contributed continuum component from all of the galaxies in our sample, we determine a lower median stellar mass for SMGs than previous studies, ∼7 × 1010 M☉. We use constraints of the starburst timescale from molecular gas studies to estimate the amount of fading our sample would undergo if they passively evolve after the starburst terminates. The results suggest that typical SMGs, while among the most massive galaxies at z ∼ 2, are likely to produce descendants of similar mass and luminosity to L* galaxies in the local universe.
Congo red-mediated regulation of levels of Shigella flexneri 2a membrane proteins

The ability of Shigella spp. to bind Congo red from agar medium is generally correlated with their virulence properties. We used a metabolically active culture of Shigella flexneri 2a to determine the effect of Congo red on its membrane protein profiles. Virulent S. flexneri grown in the presence of Congo red at 37 degrees C showed increased levels of three proteins with Mrs of 43,000, 58,000, and 63,000 (43K, 58K, and 63K proteins) in the Sarkosyl-soluble membrane fractions. The observed phenomenon was temperature dependent. At 30 or 42 degrees C the protein levels remained unaffected by the presence of Congo red. Similar regulation of the levels of the 43K, 58K, and 63K membrane proteins was also observed with Shigella dysenteriae 1 and enteroinvasive Escherichia coli, but not with enteropathogenic E. coli. The cellular uptake of Congo red seemed to be essential, but not sufficient, for regulation. All three proteins reacted with human convalescent-phase sera in immunoblots of S. flexneri 2a Sarkosyl-soluble membrane fractions. Using the 43K-specific antiserum as the primary antibody, by indirect immunofluorescence studies, we detected an increase in the level of the 43K protein in S. flexneri which had invaded epithelial cells. These observations strongly indicate that the 43K, 58K, and 63K proteins are virulence associated. We propose that the observed regulatory effect of Congo red on membrane proteins of S. flexneri is mediated through induction. Since the same regulatory effect was also observed during the invasion of epithelial cells by S. flexneri, it is suggested that Congo red mimics some host tissue factor in vitro.