Miracle-dz/UniFAR-FTUs huggingface dataset:
The Safety and Efficacy of Fentanyl Iontophoretic Transdermal System Compared with Morphine Intravenous Patient-Controlled Analgesia for Postoperative Pain Management: An Analysis of Pooled Data from Three Randomized, Active-Controlled Clinical Studies

BACKGROUND:Postoperative pain is often managed using IV patient-controlled analgesia (PCA). In this analysis of pooled data, we compared the safety and efficacy of the fentanyl iontophoretic transdermal system (ITS) with morphine IV PCA. METHODS:Data were obtained from three multicenter, randomized, active-controlled trials (N = 1941). The primary efficacy measure was success (“good”/“excellent” ratings) on the 24-h patient global assessment of the method of pain control. Pain intensity, relative dosing ratios, discontinuation rates, and adverse events were assessed. Efficacy was evaluated across age, surgery type, and body mass index (BMI). RESULTS:Comparable percentages of patients reported success on the 24-h patient global assessment of the method of pain control (fentanyl ITS, 80.5%; morphine IV PCA, 81.0%; difference = −0.5%; 95% confidence interval, −4.0% to 3.0%). Mean last pain intensity scores in the first 24 h were comparable (fentanyl ITS, 3.1; morphine IV PCA, 3.0; difference = 0.07; 95% confidence interval, −0.14 to 0.29). Relative dosing ratios of fentanyl to morphine overall and in subpopulations (age, BMI) were comparable over 6, 12, and 24 h. Fentanyl ITS was equally effective when compared with morphine IV PCA for patient subpopulations (age, surgery type, and BMI). Discontinuation rates and the incidence of adverse events were similar between groups. CONCLUSIONS:These pooled data represent one of the largest head-to-head comparisons of fentanyl versus morphine in a postoperative acute pain setting. Results suggest that fentanyl ITS is effective across subpopulations defined by age and BMI, and support a consistent safety and efficacy profile of fentanyl delivered by fentanyl ITS for postoperative pain management.
Xantusiid Lizards Have Low Energy, Water, and Food Requirements

Lizards in the family Xantusiidae (the night lizards) are known to have resting metabolic rates that are only half those of other lizards of comparable size. We evaluated whether xantusiids also have low field metabolic rates (FMR) and food requirements by measuring FMR and water flux rates with doubly labeled water in three xantusiid species in their natural habitats. Free‐living Xantusia vigilis, Xantusia henshawi, and Xantusia riversiana processed energy and water very slowly, about one‐third as fast as do other reptiles of similar size. Xantusiid lizards have a distinctive life history that is characterized by very slow growth and low reproductive rates, and they are intensely reclusive. This general lifestyle is also found in some species that live in environments with scarce food resources, such as in caves and in arid habitats, and these species may also have relatively low energy requirements.
The manifold meanings of ‘post-New Public Management’ – a systematic literature review

For more than 30 years, New Public Management has been the most popular label for public sector reform. For more than 15 years, however, New Public Management has also been heavily criticized. There is a growing trend to consider New Public Management as ‘dead’ and claim the evolution of a new reform trend, called post-New Public Management. Like New Public Management, post-New Public Management is an umbrella term that is used to prescribe and/or describe different reform trends. The aim of this article is to give a state of the art of recent post-New Public Management literature by discerning the manifold meanings of this label. For this purpose, a systematic review of 84 articles published in peer-reviewed high-quality journals has been conducted. The article shows that, so far, the post-New Public Management idea has been very influential as an ‘ideational weapon’ to indicate a crisis of the New Public Management model. The use of the post-New Public Management idea as a blueprint for future reform, however, still needs further treatment. Points for practitioners Since the 1980s, New Public Management has served as a toolbox for the reform of public administrations all over the Organisation for Economic Co-operation and Development and beyond. In the course of its ‘pick and choose’ application, New Public Management has become an object of manifold criticism. In order to overcome the New Public Management ‘leftovers’, reformers of public management have reintroduced old concepts or invented new reform tools since the late 1990s. Systematically reviewing both theoretical and empirical academic works on this ‘post-New Public Management’ movement, we – inter alia – shed light on the question of whether ‘post-New Public Management’ can be considered a (new) model for practitioners of public management reform.
Voltage-dependent sodium and calcium currents of rat myenteric neurons in cell culture.

1. Inward currents of myenteric neurons that had been grown in cell cultures prepared from the small intestines of neonatal or young adult rats were studied with tight seal whole-cell recordings. The kinetic and pharmacological properties of these neurons were analyzed. 2. All neurons had rapidly inactivating, tetrodotoxin (TTX)-sensitive Na+ currents that could be evoked by steps to potentials more positive than -50 mV. Holding potentials more negative than -65 mV were necessary to remove steady-state inactivation. No TTX-insensitive Na+ currents were observed, thus the ability of subsets of myenteric neurons to fire action potentials in TTX must depend upon their density of Ca2+ channels. 3. Ca2+ and Ba2+ currents were studied in neurons perfused internally with CsCl to block K+ currents and bathed with solutions containing TTX and antagonists of K+ channels. Currents were significantly larger when Ba2+ replaced Ca2+ as the charge carrier. Cd2+ and Gd3+ blocked Ca2+ and Ba2+ currents rapidly and reversibly. High-voltage-activated (HVA) Ca2+ and Ba2+ currents were observed in all neurons. Too few neurons possessed detectable low-voltage-activated Ca2+ currents to permit detailed study. 4. HVA Ca2+ and Ba2+ currents evoked from holding potentials more negative than -50 mV could be divided into two kinetically distinguishable components with very different rates of inactivation. A "decaying" component inactivated relatively rapidly with a t1/2 of 25-75 ms. A "sustained" component inactivated quite slowly with a t1/2 of 1-5 s. At more positive holding potentials, only the sustained component was observed. Although the two kinetically distinguishable components had different current-voltage relationships, they had indistinguishable rates of deactivation: a single time constant was sufficient to fit the decay of tail currents. The relative amplitudes of the two components varied considerably among different neurons. 5. Ca2+ and Ba2+ currents could be divided into two pharmacologically distinct components on the basis of sensitivity to omega-conotoxin GVIA (I omega CgTX) and to dihydropyridine antagonists (IDHP). At holding potentials more positive than -70 mV, a combination of omega CgTX and DHPs completely blocked Ca2+ and Ba2+ currents in most neurons. At holding potentials more negative than -50 mV, I omega CgTX and IDHP each contained decaying and sustained components. I omega CgTX activated more slowly than did IDHP. The DHP agonist Bay K8644 increased the amplitude of IDHP and slowed its rate of deactivation. 6. The results suggest that myenteric neurons may have as few as two subtypes of HVA Ca2+ channels; omega CgTX-sensitive ones and DHP-sensitive ones. (ABSTRACT TRUNCATED AT 400 WORDS)
Optical Buffering for Chip Multiprocessors: A 16GHz Optical Cache Memory Architecture

We demonstrate a 16GHz physical layer optical cache memory architecture for direct mapping associativity, organized in four cache lines with every line being capable of storing two bytes of optical data. WDM formatting of both the memory address and the optical data words is exploited, while the proposed design relies on the interconnection of subsystems that comprise experimentally proven optical building blocks. The performance of the optical cache is evaluated via physical layer simulations showing successful functionality both during Read and Write operation. Going a step further and considering a higher capacity optical cache module, we present its impact when performing with true processor workload benchmarks in Chip Multiprocessor configurations, employed as a L1 cache shared among multiple cores. Its performance is compared with the conventional electronic CMP topology, where dedicated L1 electronic caches and a shared L2 cache are used, showing that the use of optical 16GHz cache can lead to performance speed-up up to 40% while reducing the cache total capacity requirements by 84%. With optical interconnects having already resulted to high-bandwidth CPU-memory bus solutions, our optical cache architecture forms a fully compatible system solution for bridging the gap between optically connected CPU-cache schemes and high-speed optical RAM cell solutions.
Development of an automated blood sampling system for use in humans

Many hormones are released in a pulsatile or burst-like pattern resulting in fluctuating blood levels that can undergo rapid modulation by physiological and pathological signals. To accurately measure these changes in hormone concentration requires frequent blood sampling, often over extended periods as the overall rhythmicity may vary over 24 hours. The aim of this study was to develop a computerized, automated blood sampling system which allows repeated stress-free blood sample collection from humans over an extended period under basal or test conditions. The system incorporates a peristaltic pump, fraction collector and standard infusion pump together with a custom built electronic control unit linked to a personal computer. Disposable tubing prevents cross-contamination between study participants. The computer programme is modifiable to adjust for the number of specimen tubes and volume of blood collected per sampling cycle. Patency of the collecting line is maintained with 0.9% saline, without the need for heparinization. To validate the system, 10-minute samples for cortisol were collected over 24 hours from five healthy volunteers, of whom two had additional concomitant ACTH sampling. Deconvolution analysis revealed an expected number of hormone secretory episodes and a non-pathological degree of orderliness within the data. There was high concordance between ACTH and cortisol secretory events. The ability of the system to allow multiple measurements and of the software program to link with other physiological monitoring equipment provides a powerful tool to study physiologic/pathophysiologic change in relation to blood hormone and other biomarker levels.
Growth and Energy Generation by Lactococcus lactis subsp. lactis biovar diacetylactis during Citrate Metabolism

Growth of Lactococcus lactis subsp. lactis biovar diacetylactis was observed on media with citrate as the only energy source. At pH 5.6, steady state was achieved in a chemostat on a citrate-containing medium in the absence of a carbohydrate. Under these conditions, pyruvate, acetate, and some acetoin and butanediol were the main fermentation products. This indicated that energy was conserved in L. lactis subsp. lactis biovar diacetylactis during citrate metabolism and presumably during the conversion of citrate into pyruvate. The presumed energy-conserving step, decarboxylation of oxaloacetate, was studied in detail. Oxaloacetate decarboxylase was purified to homogeneity and characterized. The enzyme has a native molecular mass of approximately 300 kDa and consists of three subunits of 52, 34, and 12 kDa. The enzyme is apparently not sodium dependent and does not contain a biotin moiety, and it seems to be different from the energy-generating oxaloacetate decarboxylase from Klebsiella pneumoniae. Energy-depleted L. lactis subsp. lactis biovar diacetylactis cells generated a membrane potential and a pH gradient immediately upon addition of citrate, whereas ATP formation was slow and limited. In contrast, lactose energization resulted in rapid ATP formation and gradual generation of a proton motive force. These data were confirmed during studies on amino acid uptake. α-Aminoisobutyrate uptake was rapid but glutamate uptake was slow in citrate-energized cells, whereas lactose-energized cells showed the reverse tendency. These data suggest that, in L. lactis subsp. lactis bv. diacetylactis, a proton motive force could be generated during citrate metabolism as a result of electrogenic citrate uptake or citrate/product exchange together with proton consumption by the intracellular oxaloacetate decarboxylase.
Influence of Hip External Rotation on Hip Adductor and Rectus Femoris Myoelectric Activity During a Dynamic Parallel Squat

Pereira, GR, Leporace, G, Chagas, DV, Furtado, LFL, Praxedes, J, and Batista, LA. Influence of hip external rotation on hip adductor and rectus femoris myoelectric activity during a dynamic parallel squat. J Strength Cond Res 24(10): 2749-2754, 2010-This study sought to compare the myoelectric activity of the hip adductors (HAs) and rectus femoris (RF) when the hip was in a neutral position or externally rotated by 30° or 50° (H0, H30, and H50, respectively) during a parallel squat. Ten healthy subjects performed 10 repetitions of squats in each of the 3 hip positions and the myoelectric activities of the HAs and RF were recorded. The signal was then divided into categories representing concentric (C) and eccentric (E) contractions in the following ranges of motion: 0-30° (C1 and E1), 30-60° (C2 and E2), and 60-90° (C3 and E3) of knee flexion. From those signals, an root mean square (RMS) value for each range of motion in each hip position was obtained. All values were normalized to those obtained during maximum voluntary isometric contraction. We found that HAs showed a significant increase in myoelectric activity during C3 and E3 in the H30 and H50 positions, as compared with H0. Meanwhile, RF activity did not significantly differ between hip positions. Both muscles showed higher activation during 60-90° (C3 and E3) of knee flexion, as compared with 0-30° (C1 and E1) and 30-60° (C2 and E2). The results suggest that if the aim is to increase HA activity despite the low percentage of muscle activation, squats should be performed with 30° of external rotation and at least 90° of knee flexion.
Improved Mutual Fund Investment Choice Architecture

ABSTRACT Two choice architecture interventions were explored to debias investors' irrational preference for mutual funds with high past returns rather than funds with low fees. A simple choice task was used involving a direct trade-off between maximizing past returns and minimizing fees. In the first intervention, warning investors that “Some people invest based on past performance, but funds with low fees have the highest future results” was more effective than 3 other disclosure statements, including the U.S. financial regulator's, “Past performance does not guarantee future results. ” The second intervention involved converting mutual fund annual percentage fees into a 10-year dollar cost equivalent. This intervention also improved investors' fee sensitivity, and remained effective even as past returns increased. Financially literate participants were surprisingly more likely to irrationally maximize past returns in their investment choices.
Communication as a context of organizational behavior

Employee concerns about communication processes within California State University, San Bernardino expressed during a reaccreditation process in 1994 created the opportunity to measure perceptions about information flow that could be used for organizational change. The International Communication Association (ICA) audit was employed to deteimiine how employees receive their information and how they feel about organizational relationships and outcomes, among other issues, so that qpaantitative data could be relayed during a mid-term reaccreditation review in 1998. The issues examined revolved around the depiction or a ̂ ^poor communication climate" that was reflected in the 1994 reaccreditation findings. Specifically, communication with top management and information flow about how money is spent and decisions are made were of interest. Generally, Cal State's results were typical of most organizations audited by ICA.
Paediatric cerebral sinus vein thrombosis

Summary The etiology and pathophysiology of cerebral sinus venous thrombosis (CSVT) in the paediatric population is still poorly understood, and the role of thrombophilic risk factors remains to be elucidated. In our multi-center case-controlled study we studied 46 patients with CSVT diagnosed from April 1996 to December 2003, consecutively referred for thrombophilia work-up. The results of thrombophilia screen were compared to 112 healthy paediatric controls. Anticoagulant therapy was applied according to treating physicians’ decisions, and all cases were prospectively followed for a median of 4.1 years. Of 46 children, 8 had CSVT diagnosed in the neonatal period and therefore were analyzed separately. The prevalence of single thrombophilia markers and combinations of thrombophilic risk factors were similar among cases and controls. Among children with CSVT co-morbid systemic illness was present in most patients at diagnosis. Seven out of 8 children with idiopathic CSVT had thrombophilic risk factors as compared to 31/38 patients with co-morbid conditions. Anticoagulation was initiated in most patients, 11/46 patients continued therapy for a total of one year or more post event. Neither clinical presentation nor initial treatment decisions were affected by presence of thrombophilic risk factors in our study group. Thrombophilia prevalence was not increased in children with CSVT as compared to controls, however thrombophilia was more frequent among children with idiopathic CSVT. Thus, those selected patients would benefit most from thrombophilia work-up, required for long-term therapy considerations.
Selective spread of neurotropic herpesviruses in the rat hippocampus

Transsynaptically spreading viruses are widely used for tracing neuronal circuits in both the central and peripheral nervous systems. However, viruses are capricious tools with selective spreading properties that can produce false‐negative results. Using herpes simplex virus type 1 and two pseudorabies virus strains, we aimed at mapping quantitatively neuronal connections in the rat hippocampus. We found that none of the tested viruses infected CA3 pyramidal neurons across synapses following inoculation into the CA1 area. Combined injections of the viruses with the retrograde tracer cholera toxin B (CTB) resulted in CTB, but not virus labeling of CA3 pyramidal neurons. In contrast, other brain regions known to send inputs to the CA1 (the entorhinal cortex, medial septum and diagonal band of Broca, raphe nuclei) were transsynaptically infected. Our results indicate that Schaffer collaterals of CA3 pyramidal cells lack the appropriate cellular machinery for successful neurotropic herpesvirus infection. After injections of viruses into the dentate gyrus/CA3 area, we found labeling in commissurally projecting mossy cells and their afferent granule cells but not in contralateral CA3 pyramidal cells. Using this unique spreading property, we estimated that single mossy cells receive input from a compact cluster of 30–40 granule cells. J. Comp. Neurol. 496:229–243, 2006. © 2006 Wiley‐Liss, Inc.
Simultaneous Fine Mapping of Multiple Closely Linked Quantitative Trait Loci Using Combined Linkage Disequilibrium and Linkage With a General Pedigree

Within a small region (e.g., <10 cM), there can be multiple quantitative trait loci (QTL) underlying phenotypes of a trait. Simultaneous fine mapping of closely linked QTL needs an efficient tool to remove confounded shade effects among QTL within such a small region. We propose a variance component method using combined linkage disequilibrium (LD) and linkage information and a reversible jump Markov chain Monte Carlo (MCMC) sampling for model selection. QTL identity-by-descent (IBD) coefficients between individuals are estimated by a hybrid MCMC combining the random walk and the meiosis Gibbs sampler. These coefficients are used in a mixed linear model and an empirical Bayesian procedure combines residual maximum likelihood (REML) to estimate QTL effects and a reversible jump MCMC that samples the number of QTL and the posterior QTL intensities across the tested region. Note that two MCMC processes are used, i.e., an (internal) MCMC for IBD estimation and an (external) MCMC for model selection. In a simulation study, the use of the multiple-QTL model clearly removes the shade effects between three closely linked QTL located at 1.125, 3.875, and 7.875 cM across the region of 10 cM, using 40 markers at 0.25-cM intervals. It is shown that the use of combined LD and linkage information gives much more useful information compared to using linkage information alone for both single- and multiple-QTL analyses. When using a lower marker density (11 markers at 1-cM intervals), the signal of the second QTL can disappear. Extreme values of past effective size (resulting in extreme levels of LD) decrease the mapping accuracy.
Populism and competitive authoritarianism in Turkey

ABSTRACT The main goal of this paper is to explain the rise of competitive authoritarianism in Erdoğan’s Turkey. The recent literature has mainly focused on the taxonomical debate about the type of regime established by Erdoğan, dealing only rarely with the factors explaining the Turkish autocratization. Building on Levitsky and Loxton’s framework, which underlines the catalyst role played by the election of populist leaders for the rise of competitive authoritarianism in Latin America, the analysis identifies the interactions among Erdoğan’s populism and threats and opportunities provided by both domestic and international environments as the major cause explaining Turkish autocratization.
Shocks, social protection, and resilience: Evidence from Ethiopia

The malign effect of shocks has long been a concern within economics, partly because they result in transitory welfare losses and partly because they may have persistent effects. In development discourse, this latter concern has spurred interest in the concept of resilience and how public interventions can enhance resilience. Within this context, we assess the impact of a social protection program, Ethiopia’s Productive Safety Net Program, on the longer term impacts of drought on household food security. We find that drought shocks reduce the number of months a household considers itself food secure and that these impacts persist for up to four years after the drought has ended. Using a Hausman instrumental variable estimator, we find that receipt of PSNP payments reduced the initial impact of drought shocks by 57 percent and eliminates their adverse impact on food security within two years. In this way, the PSNP strengthens the resilience of its beneficiaries against adverse shocks. This impact is largest for PSNP beneficiaries with little or no land. Results are robust to using an objective measure of drought derived from satellite data, the Standard Evapotranspiration Index. They are also robust to changes in sample composition, the presence of other interventions, and the estimator used.