Miracle-dz/UniFAR-FTUs huggingface dataset:
Structure of Human Urokinase Plasminogen Activator in Complex with Its Receptor

The urokinase plasminogen activator binds to its cellular receptor with high affinity and initiates signaling cascades that are implicated in pathological processes including tumor growth, metastasis, and inflammation. We report the crystal structure at 1.9 angstroms of the urokinase receptor complexed with the urokinase amino-terminal fragment and an antibody against the receptor. The three domains of urokinase receptor form a concave shape with a central cone-shaped cavity where the urokinase fragment inserts. The structure provides insight into the flexibility of the urokinase receptor that enables its interaction with a wide variety of ligands and a basis for the design of urokinase-urokinase receptor antagonists.
Investigating arm symmetry in swimming using inertial sensors

This research used an sacrum mounted self developed inertial sensor, which provides triaxial accelerometers and gyroscopes, RF capability and 2GB on-board memory in a waterproof casing to investigate the arm symmetry in freestyle swimming. The recorded acceleration data was filtered using a high-pass Hamming windowed FIR filter to remove the sensor orientation from the wanted signal. The signal was then analyzed using a zero-crossing detection algorithm to find the individual stroke rates (SR) and the differences between left and right arm stroke durations (asymmetry).
Self-Efficacy and Postpartum Depression Teaching Behaviors of Hospital-Based Perinatal Nurses

Based upon the Self-Efficacy Theory, this study examined the relationship between self-efficacy, self-efficacy-related variables, and postpartum depression teaching behaviors of hospital-based perinatal nurses. Findings revealed that teaching new mothers about postpartum depression is related to a perinatal nurse’s self-efficacy in postpartum-depression teaching, self-esteem, and the following self-efficacy-related variables: social persuasion (supervisor’s expectations for teaching); mastery (postpartum depression continuing education and teaching experience); and vicarious experience (observing other nurses teach new mothers about postpartum depression). Teaching new mothers about postpartum depression can assist mothers in overcoming barriers to depression treatment. Nurse educators and managers play an important role in encouraging postpartum depression education for perinatal nurses.
The effect of intra‐operative transcutaneous electrical nerve stimulation on posterior neck pain following thyroidectomy

Posterior neck pain following thyroidectomy is common because full neck extension is required during the procedure. We evaluated the effect of intra‐operative transcutaneous electrical nerve stimulation on postoperative neck pain in patients undergoing total thyroidectomy under general anaesthesia. One hundred patients were randomly assigned to one of two groups; 50 patients received transcutaneous electrical nerve stimulation applied to the trapezius muscle and 50 patients acted as controls. Postoperative posterior neck pain and anterior wound pain were evaluated using an 11‐point numerical rating scale at 30 min, 6 h, 24 h and 48 h following surgery. The numerical rating scale for posterior neck pain was significantly lower in the transcutaneous electrical nerve stimulation group compared with the control group at all time points (p < 0.05). There were no significant differences in the numerical rating scale for anterior wound pain at any time point. No adverse effects related to transcutaneous electrical nerve stimulation were observed. We conclude that intra‐operative transcutaneous electrical nerve stimulation applied to the trapezius muscle reduced posterior neck pain following thyroidectomy.
Temperature-dependent exciton linewidths in semiconductors.

The temperature-dependent linewidths of excitons in semiconductors due to the interaction of the exciton with both LO phonons and with acoustic phonons are studied with use of a Green's-function approach in which the exciton-phonon interaction is treated perturbatively. The interaction between the excitons and the LO phonons is taken to be of the Fr\"ohlich form, and the contribution to the linewidth is obtained in closed form. In this case it is found that scattering of the exciton to both bound and continuum states is important and that it is important to treat the continuum states fully as Coulomb scattering states. In describing optical-absorption processes, the fact that absorption occurs from polariton states, which are states composed of excitons coupled to light, is taken into account. The linewidths due to the exciton\char21{}LO-phonon interaction are evaluated for a series of II-VI and III-V compound semiconductors, and are shown to account for the existing experimental results for temperatures \ensuremath{\gtrsim}80 K. The contributions to the linewidth due to the interaction of excitons with acoustic phonons via both the deformation potential and the piezoelectric couplings are treated, and it is found that the deformation-potential coupling dominates for all of the materials considered. Because of the small velocity of sound, scattering to only intraband intermediate states, i.e., those in which the internal exciton quantum numbers do not change, is found to contribute to the linewidth. In the case of acoustic phonons, it is found to be important to treat optical absorption as originating from polariton states in order to evaluate properly the magnitude of this contribution to the linewidth. The acoustic-phonon contribution to the linewidths is compared with experiment for temperatures \ensuremath{\lesssim}80 K, for which it dominates the temperature dependence.
A Review of Risk Identification Approaches in the Telecommunication Domain

Risks in the telecommunication (telco) domain are complex to identify due to the involvement of several independent stakeholders and the difficulty of predicting emerging threats to the services. This is costing the Telecom operators billions of dollars. We believe the little emphasis given to the important step of risk assessment process – risk identification (RI) – is the main reason for this loss. Unlike other domains, the proprietary nature of Telecom systems makes it challenging to show the risk assessment approaches in the domain. In this paper, we investigate the classifications of the RI approaches from the literature written on the telco and other related domains. We also investigate the research trends in the last 16 years when Telecom risks are evolving and the revenue loss of Telecom operators is largely affected. Based on our review, we also show future research directions in the domain.
Hierarchical Chamfer Matching: A Parametric Edge Matching Algorithm

The algorithm matches edges by minimizing a generalized distance between them. The matching is performed in a series of images depicting the same scene with different resolutions, i.e. in a resolution pyramid. Using this hierarchical structure reduces the computational load significantly. The algorithm is reasonably simple to implement and is insensitive to noise and other disturbances. The algorithm has been tested in several applications. Two of them are briefly presented. In the first application the outlines of common tools are matched to gray-level images of the same tools, with overlapping. In the second application lake edges from aerial photographs are matched to lake edges from a map, with translation, rotation, scale, and perspective changes. The hierarchical chamfer matching algorithm gives correct results using a reasonable amount of computational resources in all tested applications. >
Assessing e‐commerce systems success: a respecification and validation of the DeLone and McLean model of IS success

Abstract. DeLone & McLean (2003) propose an updated information systems (IS) success model and suggest that it can be extended to investigating e‐commerce systems success. However, the updated IS success model has not been empirically validated in the context of e‐commerce. Further, the existing IS/e‐commerce success models have been subject to considerable debate on the ‘IS Use’ and ‘Perceived Usefulness’ constructs, and the nomological structure of the updated DeLone and McLean model is somewhat inconsistent with the IS acceptance and marketing literature. Based on the IS and marketing literature, this paper respecifies and validates a multidimensional model for assessing e‐commerce systems success. The validated model consists of six dimensions: Information Quality, System Quality, Service Quality, Perceived Value, User Satisfaction and Intention to Reuse. Structural equation modelling techniques were applied to data collected by questionnaire from 240 users of e‐commerce systems in Taiwan. The empirical evidence suggests that Intention to Reuse is affected by Perceived Value and User Satisfaction, which, in turn, are influenced by Information Quality, System Quality and Service Quality. The nomological structure of the respecified e‐commerce systems success model is concurred with that of the technology acceptance model (TAM) in the IS field and the consumer behaviour models in the traditional business‐to‐business and retail contexts. The findings of this study provide several important implications for research and practice. This paper concludes by discussing the contributions of this study and the limitations that could be addressed in future studies.
Cutting Edge Commentary: Immune Responses in the Absence of Costimulation: Viruses Know the Trick

Costimulatory molecules are crucial for the induction of immune responses after immunization with purified proteins or peptides. However, some viruses and other pathogens are able to induce protective immunity in the absence of such molecules. This review argues that patterns recognized by both the specific and the innate immune system, together with a high and sustained Ag-load, are responsible for these surprisingly efficient immune responses triggered by pathogens.
Increased Interstitial Concentrations of Glutamate and Pyruvate in Vastus Lateralis of Women with Fibromyalgia Syndrome Are Normalized after an Exercise Intervention – A Case-Control Study

Background Fibromyalgia syndrome (FMS) is associated with central alterations, but controversies exist regarding the presence and role of peripheral factors. Microdialysis (MD) can be used in vivo to study muscle alterations in FMS. Furthermore for chronic pain conditions such as FMS, the mechanisms for the positive effects of exercise are unclear. This study investigates the interstitial concentrations of algesics and metabolites in the vastus lateralis muscle of 29 women with FMS and 28 healthy women before and after an exercise intervention. Methods All the participants went through a clinical examination and completed a questionnaire. In addition, their pressure pain thresholds (PPTs) in their upper and lower extremities were determined. For both groups, MD was conducted in the vastus lateralis muscle before and after a 15-week exercise intervention of mainly resistance training of the lower limbs. Muscle blood flow and interstitial muscle concentrations of lactate, pyruvate, glutamate, glucose, and glycerol were determined. Results FMS was associated with significantly increased interstitial concentrations of glutamate, pyruvate, and lactate. After the exercise intervention, the FMS group exhibited significant decreases in pain intensity and in mean interstitial concentrations of glutamate, pyruvate, and glucose. The decrease in pain intensity in FMS correlated significantly with the decreases in pyruvate and glucose. In addition, the FMS group increased their strength and endurance. Conclusion This study supports the suggestion that peripheral metabolic and algesic muscle alterations are present in FMS patients and that these alterations contribute to pain. After an exercise intervention, alterations normalized, pain intensity decreased (but not abolished), and strength and endurance improved, all findings that suggest the effects of exercise are partially peripheral.
Single‐fiber electromyography in neuromuscular disorders: Correlation of muscle histochemistry, single‐fiber electromyography, and clinical findings

We performed single‐fiber electromyography (SFEMG) and correlated the results with muscle‐biopsy histochemistry in 56 patients with various neuromuscular diseases. Increased muscle‐fiber density, delineated by SFEMG, was most prominent in diseases of ordinary denervation, namely motor neuron disorders and peripheral neuropathies, and it correlated with histochemical fiber type grouping. Both phenomena reflect denervation followed by reinnervation. In patients with central core disease and rod disease, fiber density was not increased despite massive type I fiber predominance. The normal distribution of type I fiber subtypes in those patients indicated that their fiber predominance was not due to sprouting and reinnervation, but probably to paucity of the type II fibers. In type I fiber hypotrophy with central nuclei, fiber density was increased, perhaps attributable to the small diameter and consequent denser packing of the type I fibers. Fiber density was slightly increased in the majority of patients with acidmaltase deficiency, limb‐girdle dystrophy, and polymyositis, in nearly half with mitochondrial myopathy, and in 1 older Duchenne dystrophy patient. In these myopathic disorders, myogenous deinnervation (followed by reinnervation) is one possible explanation. Normal fiber density was present in all patients with muscle phosphorylase deficiency, myotonia congenita, and in the hypokalemic periodic paralysis patients under age 40. © 1994 John Wiley & Sons, Inc.
High‐dose zidovudine induction in HTLV‐I‐associated myelopathy

Ten HTLV-I-associated myelopathy (HAM) patients (four men and six women aged 38 to 58 years) with Expanded Disability Status Scale (EDSS) scores ranging from 4.0 to 8.5 entered an open-label zidovudine study. A high-dosage induction (2 g/d for 4 weeks) was followed by 1 g/d for 20 weeks. Five patients were natives of the Caribbean island Hispaniola, and one each was from Colombia, Cuba, El Salvador, Jamaica, and the United States; all were positive by polymerase chain reaction, and nine had positive Western immunoblots for HTLV-I. Side effects included anxiety, insomnia, gastric upset, anorexia, and loss of taste. Preexisting leg cramps were increased in two and headaches in one. Hemoglobin decreased from a mean of 13.5 to 11.8 g/dl and the hematocrit from 40.7% to 34.9% at 8 weeks, and then stabilized. Neutropenia appeared regularly but did not necessitate drug withdrawal. Mean EDSS scores changed little for the group as a whole, but the seven ambulatory patients improved objectively, with their scores dropping from 5.5 to 4.0 and none worsening. Timed gait improved by at least 50%. Following withdrawal, four of the five who had improved regressed. Zidovudine appears to be safe in subjects with HAM who have no other major health problems and should be investigated further.
In vitro bactericidal and in vivo therapeutic activities of a new rifamycin derivative, KRM-1648, against Mycobacterium tuberculosis

The in vitro and in vivo activities of a new rifamycin derivative, KRM-1648, against Mycobacterium tuberculosis H37Rv were compared with those of rifampin. Bactericidal activity was evaluated by using a silicone-coated slide culture method. The MBC of KRM-1648 was 0.15 to 0.3 microgram/ml for 24 h of exposure, while that of rifampin was > 160 microgram/ml under the same conditions. Against experimental murine tuberculosis, KRM-1648 exhibited significant therapeutic effects, in terms of prolonged survival times for mice compared with those with rifampin treatment, even at lower doses, such as 1 and 3 mg/kg. At a dose of 3 mg/kg, KRM-1648 was at least as effective as rifampin at 10 mg/kg. The combination of KRM-1648 (3 mg/kg) plus isoniazid (3 mg/kg) plus ethambutol (10 mg/kg) exhibited much more activity than did rifampin (10 mg/kg) plus isoniazid (3 mg/kg) plus ethambutol (10 mg/kg). These findings suggest that KRM-1648 is a promising candidate for the treatment of tuberculosis.
Acclimation of Photosynthetic and Respiratory Carbon Dioxide Exchange to Growth Temperature in Atriplex lentiformis (Torr.) Wats.

Atriplex lentiformis plants collected from coastal and desert habitats exhibit marked differences in capacity to adjust photosynthetic response to changes in growth temperature. Plants from desert habitats grown at 43 C day/30 C night temperatures had higher CO(2) uptake rates at high temperatures but reduced rates at low temperatures as compared to plants grown at 23 C day/18 C night temperatures. In contrast, growth of the coastal plants at high temperatures resulted in markedly reduced photosynthetic rates at all measurement temperatures.Leaf conductances to CO(2) were not important in controlling either the differences in the temperature dependence of net CO(2) uptake or the differences in photosynthetic capacities at any measurement temperature. At low measurement temperatures, differences in photosynthetic capacities among plants acclimated to the contrasting growth regimes were correlated with differences in leaf ribulose diphophate carboxylase activities. At high measurement temperatures, the improved net photosynthetic performance of the high temperature acclimated desert plants appeared to be due to a combination of decreased respiration rates, decreased temperature dependence of respiration, and an apparent increased thermal stability of photosynthetic CO(2) exchange.
Revision of Failed Bone Grafting for Nonunion of the Scaphoid: Treatment Options and Results

Failure of bone grafting in scaphoid nonunion presents the hand surgeon a perplexing set of problems. Controversy remains as to the best course of treatment in this difficult situation. The authors have retrospectively reviewed during a 5-year period the patients treated at the Mayo Clinic who have gone on to a second nonunion after a failed initial bone grafting procedure. Twenty-five patients were identified, 19 of whom had a second bone grafting procedure. Depending on the preoperative evaluation, 4 types of bone grafting procedures were performed: conventional Russe procedure, 4; Maltese cross bone graft procedure, 6; interpositional wedge graft, 5; and vascularized pedicle bone graft, 4. Twenty-two of 25 united (88%). Average followup at 57 months (range, 25-90 months), shows satisfactory results (16% very satisfied and 8% moderately satisfied), but varying degrees of pain. Results using a modification of the Mayo Wrist Score are somewhat disappointing with 3 excellent, 5 good, 10 fair, and 7 poor. It must be remembered, however, these wrists have had at least 2 surgeries, multiple long periods of immobilization, and often a delay in treatment with a prolonged period of abnormal carpal mechanics. It is thought that a second bone grafting attempt should be strongly considered. The key to success is matching the type of bone graft procedure to the specific unique features of scaphoid shortening, carpal instability, and proximal pole vascularity that each patient's wrist displays. A treatment algorithm is presented to help decision making in this difficult problem.
The Use of Ultrasound and other Markers for Early Detection of Preeclampsia

Preeclampsia (PE) is a multisystem disorder of pregnancy classically characterized with the onset of hypertension after 20 weeks gestation in the presence of proteinuria. PE typically affects 2–8% of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This article reviews the most effective biomarkers used in first trimester screening for PE. It explores their use both in isolation and as part of an algorithm to yield the best detection rates. Screening by a combination of maternal risk factors, uterine artery Doppler, mean arterial pressure, maternal serum PAPP-A and PlGF can identify about 75% of cases of preterm PE for a false-positive rate of 10%. By identifying these patients at high risk for PE, appropriately tailored antenatal surveillance can be instigated and prophylactic pharmacological interventions can be prescribed to improve placentation and ultimately, the outcome for both the mother and fetus.
Bitreatment of Industrial Oil Waste Water by Free and Immobilized Rhodotorula mucilaginosa 2 and Candida utilis

The ability of Rhodotorula mucilaginosa 2 and Candida utilis in its free and immobilized cases on two different matrices Ca-alginate and chitosan to treated industrial oil waste water were investigated. R. mucilaginosa 2 and C. utilis were isolated from industrial oil waste water and identified morphologically under light microscope (40X) and biochemically by using API 20 CAUX (bioMérieux) identification kit. Oil and greases (O&G), chemical oxygen demand (COD), total dissolved solid (TDS) and electric conductivity (EC) were estimated as indicator for treatment of industrial oil waste after 2, 4 and 6 days. The ability of R. mucilaginosa 2 for treatment oil waste water was higher than the ability of Candida utilis in which free R. mucilaginosa 2 gave degradation efficiency of removal of O&G, COD, TDS and EC were 50%, 70%, 30% and 8% respectively. The efficiency of removal of oil, COD, TDS and EC by immobilized R. mucilaginosa 2on Ca-alginate was 60%, 77%, 37% and 14% respectively. On other hand the removal efficiency rate of oil, COD, TDS and EC by immobilized cells on chitosan was 70%, 77%, 37% and 15% respectively. The removal efficiency of O&G, COD, TDS and EC by free Candida utilis after 6 days of treatment were 21%, 54%, 12% and 16% respectively. The efficiency of removal of oil, COD, TDS and EC by immobilized Candida utilis on Ca-alginate was 60%, 65%, 29% and 19% respectively, on the other hand, the removal efficiency of O&G, COD, TDS and EC by immobilized Candida utilis on chitosan was 60%, 76%, 41% and 37% respectively. The results indicated that immobilized substrate types was an important factor to affect degradation ability of R. mucilaginosa 2 and Candida utilis.
Treatment of cicatricial pemphigoid with tetracycline and nicotinamide

Cicatricial pemphigoid is a rare autoimmune blistering disease involving predominantly mucosal areas in elderly patients. It runs a chronic relapsing course. Immunosuppressive treatments are frequently complicated by adverse effects and require careful monitoring. A 69‐year‐old woman is reported who responded well to a simple regimen of combined tetracycline and nicotinamide after 15 years of inadequate disease control and numerous adverse effects from immunosuppressive agents.