Miracle-dz/UniFAR-FTUs huggingface dataset:
Critical assessment of the efficiency of CD34 and CD133 antibodies for enrichment of rabbit hematopoietic stem cells

Rabbits have many hereditary diseases common to humans and are therefore a valuable model for regenerative disease and hematopoietic stem cell (HSC) therapies. Currently, there is no substantial data on the isolation and/or enrichment of rabbit HSCs. This study was initiated to evaluate the efficiency of the commercially available anti‐CD34 and anti‐CD133 antibodies for the detection and potential enrichment of rabbit HSCs from peripheral blood. PBMCs from rabbit and human blood were labelled with different clones of anti‐human CD34 monoclonal antibodies (AC136, 581, and 8G12) and rabbit polyclonal CD34 antibody (pCD34) and anti‐human CD133 monoclonal antibodies (AC133 and 293C3). Flow cytometry showed a higher percentage of rabbit CD34+ cells labelled by AC136 in comparison to the clone 581 and pCD34 (P < 0.01). A higher percentage of rabbit CD133+ cells were also detected by 293C3 compared to the AC133 clone (P < 0.01). Therefore, AC136 clone was used for the indirect immunomagnetic enrichment of rabbit CD34+ cells using magnetic‐activated cell sorting (MACS). The enrichment of the rabbit CD34+ cells after sorting was low in comparison to human samples (2.4% vs. 39.6%). PCR analyses confirmed the efficient enrichment of human CD34+ cells and the low expression of CD34 mRNA in rabbit positive fraction. In conclusion, the tested antibodies might be suitable for detection, but not for sorting the rabbit CD34+ HSCs and new specific anti‐rabbit CD34 antibodies are needed for efficient enrichment of rabbit HSCs. © 2018 American Institute of Chemical Engineers Biotechnol. Prog. , 2018 © 2018 American Institute of Chemical Engineers Biotechnol. Prog. , 34:1278–1289, 2018
Social domain based modulation of neural responses to threat: The different roles of romantic partners versus friends

ABSTRACT The neural circuitry associated with threat regulation in the absence of other people is well established. An examination of threat regulatory processes with people from different domains of an individual’s social world is key to understanding social emotion regulation and personality functioning conceptualised as social domain organisation. In this study, 42 healthy female participants completed functional magnetic imaging sessions in which they underwent a scan in the presence of a romantic partner or friend, whilst completing a threat of shock task. In the presence of a romantic partner vs. friend, we found a reduction in amygdala activation to threat vs. safe trials over time. Furthermore, in the presence of a romantic partner vs. friend we observed greater subgenual anterior cingulate cortex and ventromedial prefrontal cortex activation to threat vs. safe trials overall. The results support the hypothesis that recruitment of threat regulation circuitry is modulated by romantic partner relative to another person well-known to the individual. Future work needs to examine neural responses to a wider range of stimuli across more social domains, and implications of failures of this neural organisation for psychopathology.
The impact of ICT ’ s on students ’ performance in Higher Education : Direct effects , Indirect effects and Organizational change

The purpose of the present paper is to examine the relationship between the use of Information and Communication Technologies (ICT) and students’ performance in Higher Education. Earlier economic research has failed to provide a clear consensus on the effect of ICTs' investments on student's achievement. Our paper aims at summarizing the main findings of the literature and to give two complementary explanations. The first one focuses on the indirect effects of ICT on standard explanatory factors. Since student’s performance is mainly explained by student’s characteristics, educational environment and teachers characteristics, ICT may impact those determinants and consequently the outcome of education. The differences observed in students’ performances are thus more related to the differentiated impact of ICT on standard explanatory factors. The second thesis advocates that ICT uses need a change in the organization of the Higher Education. While ICT equipment and uses rates are growing very fast in the European Union, the adoption of complementary organizational designs is very slow and differs from one institution to another. This may explain the observed differences in student’s achievement. * This Work is partially funded by the European Commission, eLene-EE project: Creating models for the efficient use of elearning. Introducing Economics of elearning – eLene-EE. European Commission (EAC/23/05 SE001). General Directorate for Education and Culture. Participants: University of Umeå, CANEGE (University of Nancy 2-Vidéoscop, University of Nancy, University of Paris-Sud), UOC, METIDMilano Polithecnic, Maria Curie Sklodowska University (Polish Virtual University). February 2006-July 2008.
Dream Recall Frequency and Unusual Dream Experiences in Early Adolescence: Longitudinal Links to Behavior Problems

Unique dream patterns are related to psychopathological distress in adults. In adolescence, this was investigated almost exclusively regarding nightmares. This longitudinal study examines developmental trajectories of various adolescent-reported dream patterns, and their associations with parent-reported psychopathology (internalization and externalization problems) in early adolescence. Ninety-four 10- to 11-year-old normally developing children completed a week of sleep, dreaming, and pubertal development assessments. Parents reported behavior problems. Assessments were repeated after 1 and 2 years. Reports of unusual dreams decreased over time, and dream recall decreased among girls. Internalizing symptoms longitudinally predicted an increase in dream recall and unusual dreams. Moreover, unusual dreams longitudinally predicted increased behavior problems (internalization and externalization). Assessing dream patterns during early adolescence may help early detection of covert psychopathological distress.
Interference competition pressure predicts the number of avian predators that shifted their timing of activity

Being active at different times facilitates the coexistence of functionally similar species. Hence, time partitioning might be induced by competition. However, the relative importance of direct interference and indirect exploitation competition on time partitioning remains unclear. The aim of this study was to investigate the relative importance of these two forms of competition on the occurrence of time-shifting among avian predator species. As a measure of interference competition pressure, we used the species richness of day-active avian predator species or of night-active avian predator species (i.e. species of Accipitriformes, Falconiformes and Strigiformes) in a particular geographical area (assemblage). As an estimate of exploitation competition pressure, we used the total species richness of avian predators in each assemblage. Estimates of the intensity of interference competition robustly predicted the number of Accipitriformes species that became crepuscular and the number of Strigiformes species that became day-active or strictly crepuscular. Interference competition pressure may depend on body size and on the total duration of the typical active period (day or night length). Our results support—to some extent—that smaller species are more likely to become time-shifters. Day length did not have an effect on the number of time-shifter species in the Accipitriformes. Among the large Strigiformes, more time-shifter species occur in areas where nights are shorter (i.e. where less of the typical time resource is available). However, in the small Strigiformes, we found the opposite, counterintuitive effect: more time-shifters where nights are longer. Exploitation competition may have had an additional positive effect on the number of time-shifters, but only in Accipitriformes, and the effect was not as robust. Our results thus support the interference competition hypothesis, suggesting that animals may have shifted their time of activity, despite phylogenetic constraints on the ability to do so, to reduce the costs of direct interactions. Our findings also highlight the influence of body size as a surrogate of competitive ability during encounters on time partitioning, at least among avian predators.
Spatiotemporal Low-Rank Modeling for Complex Scene Background Initialization

Background modeling constitutes the building block of many computer-vision tasks. Traditional schemes model the background as a low rank matrix with corrupted entries. These schemes operate in batch mode and do not scale well with the data size. Moreover, without enforcing spatiotemporal information in the low-rank component, and because of occlusions by foreground objects and redundancy in video data, the design of a background initialization method robust against outliers is very challenging. To overcome these limitations, this paper presents a spatiotemporal low-rank modeling method on dynamic video clips for estimating the robust background model. The proposed method encodes spatiotemporal constraints by regularizing spectral graphs. Initially, a motion-compensated binary matrix is generated using optical flow information to remove redundant data and to create a set of dynamic frames from the input video sequence. Then two graphs are constructed, one between frames for temporal consistency and the other between features for spatial consistency, to encode the local structure for continuously promoting the intrinsic behavior of the low-rank model against outliers. These two terms are then incorporated in the iterative Matrix Completion framework for improved segmentation of background. Rigorous evaluation on severely occluded and dynamic background sequences demonstrates the superior performance of the proposed method over state-of-the-art approaches.
Ischemic Stroke Detection by Analyzing Heart Rate Variability in Rat Middle Cerebral Artery Occlusion Model

Although early reperfusion therapy is effective for acute ischemic stroke, limited therapeutic time-window resulted in only 10% of patients receiving reperfusion therapy. A fast and reliable stroke detection method is desired so that patients can receive early reperfusion therapy. It has been reported that ischemic stroke affects heart rate variability (HRV), which reflects activities of the autonomic nervous function. Thus, ischemic stroke may be detected at an acute stage through monitoring HRV. This paper proposes an HRV-based ischemic stroke detection algorithm by using multivariate statistical process control (MSPC), which is a well-known anomaly detection algorithm. As a feasibility study before collecting a large amount of clinical data from human patients, this paper used the middle cerebral artery occlusion (MCAO) model in rats for collecting HRV data shortly after ischemic stroke onsets. The 11 MCAO-operated rats and 11 sham-operated rats were prepared, and HRV data of three sham-operated rats were used for model construction. The data on the other 19 rats were used for its validation. The experimental result showed that sensitivity and specificity of the proposed algorithm were 82% and 75%, respectively. Thus, the present work shows the possibility of realizing an HRV-based ischemic stroke detection system for human patients.
Psychological factors of healthful diet promotion among diabetics: an application of health action process approach

Background and aim Worldwide, type 2 diabetes mellitus (T2DM) prevalence has increased. Non-healthful diet is one of the main reasons to T2DM growth. This study aims to determine the efficacy of the health action process approach (HAPA) in explaining healthful diet (HD) in T2DM patients. Methods This cross-sectional study was conducted based on HAPA in Isfahan, Iran between July and December 2015. Participants were recruited by convenience sampling method. HAPA inventory was administered to 203 Isfahan diabetics. Intentions, outcome expectancies, risk perception, action self-efficacy, action and coping planning, maintenance and recovery self-efficacy, and dietary style were the constructs measured. Structural equation modeling (SEM) in AMOS 21 was used to test the hypothesis. Results The results based on the common fit indices revealed that the HAPA fitted the data acceptably well among the T2DM patients and within dietary behavior (p<0.001), RMSEA=0.082, CFI=0.903, NFI=0.899). Action self-efficacy was the best predictor of intention (β=2.49, p<0.001). Result revealed action and coping planning (β=5.36, p=0.027) and recovery self-efficacy (β=5.67, p=0.021) significantly predicted behavior. Conclusions Our findings provide preliminary support for the practical usage of the HAPA model for predicting HD intention and behavior among T2DM patients. Randomized controlled trials should be performed in the future in order to involve causality.
Spindle activity in young children with autism, developmental delay, or typical development

Objective To determine whether spindle activity differs in young children with and without autism. Methods We investigated differences in spindle density, duration, and oscillatory features in 135 young children with autism, developmental delay without autism (DD), or typical development (TD) and secondarily assessed the dimensional relationship between spindle density and both cognitive ability and social functioning. Results Compared to TD, both spindle density (Cohen d 0.93, 95% confidence interval [CI] 0.49–1.37) and duration (Cohen d 0.58, 95% CI 0.15–1.01) were significantly decreased in autism. Spindle density was also significantly reduced in autism compared to DD (Cohen d 0.61, 95% CI 0.13–1.09). Decreased spindle frequency in autism compared to both TD (Cohen d 0.47, 95% CI 0.04–0.90) and DD (Cohen d 0.58, 95% CI 0.10–1.06) did not survive correction. The DD group did not differ significantly from the TD group on any spindle parameter. These results, suggesting a relationship between spindle density and autism but not DD, were further illustrated in exploratory analyses, wherein nonverbal ratio IQ (RIQ) and the Vineland Socialization domain standard score were strongly correlated with spindle density in the full sample (r = 0.33, p ≤ 001 and r = 0.41, p ≤ 001, respectively) but not within group. After nonverbal RIQ was accounted for, the relationship between spindle density and Vineland Socialization remained statistically significant (r = 0.23, p < 0.01). However, Vineland Socialization scores accounted for the relationship between spindle density and nonverbal RIQ (r = 0.04, p = 0.67). Conclusion In a large cohort of young children with autism, spindle density was reduced compared to groups of age-matched children with DD or TD. Alterations in the maturational trajectory of spindles may provide valuable insight into the neurophysiologic differences related to behavior in disorders of neurodevelopment.
Language mapping with navigated transcranial magnetic stimulation in pediatric and adult patients undergoing epilepsy surgery: Comparison with extraoperative direct cortical stimulation

Navigated transcranial magnetic stimulation (nTMS) is becoming increasingly popular in noninvasive preoperative language mapping, as its results correlate well enough with those obtained by direct cortical stimulation (DCS) during awake surgery in adult patients with tumor. Reports in the context of epilepsy surgery or extraoperative DCS in adults are, however, sparse, and validation of nTMS with DCS in children is lacking. Furthermore, little is known about the risk of inducing epileptic seizures with nTMS in pediatric epilepsy patients. We provide the largest validation study to date in an epilepsy surgery population.
Knowledge, attitude, and practice on and willingness to pay for human papillomavirus vaccine: a cross-sectional study in Hanoi, Vietnam

Background Despite its effectiveness in preventing human papillomavirus (HPV) infection, the rate of uptake of the HPV vaccine is low in Vietnam. This study aimed to investigate barriers related to knowledge–attitude–practice (KAP) about the HPV vaccine and willingness to pay (WTP) for the vaccine among those using services in an urban vaccination clinic in Hanoi, Vietnam. Materials and methods A cross-sectional study was conducted in a vaccination clinic of the Institute for Preventive Medicine and Public Health in Hanoi, Vietnam, from March to April 2016. KAP on the HPV vaccine was collected using a structured questionnaire. Double-bounded dichotomous-choice questions with open-ended questions were used to examine the WTP of respondents. Interval regression and stepwise logistic models were used to identify factors associated with WTP and the average amount that people would be willing to pay for the vaccine. Results Of 492 vaccination service users, 67.9%, 94.6%, and 12.3% of respondents were aware of the best age for HPV vaccination, its benefits, and the target group for vaccination, respectively. While the majority believed that the HPV vaccine was safe (92.8%) and effective (90.8%), and desired to be vaccinated (71.1%), only 31.8% of users were vaccinated. Most of the respondents were willing to pay for the HPV vaccine (86.6%), and willing to pay an average amount of US$49.3. Those aged 20–29 years and earning more than 22 million VND/month (very rich) were more likely to pay for the HPV vaccine than people aged <20 years and earning <7 million VND/month. Users who had attained more than a high-school education and heard about the HPV vaccine from doctors, nurses, or other health professionals tended to be willing to pay for the vaccine at a lower price than individuals with below secondary-level education and who had not heard about the vaccine from these health professionals. Conclusion Sexual health education and financial assistance should be imparted alongside the HPV vaccination program.
Analysis of Lightweight Encryption Scheme for Fog-to-Things Communication

The growing concerns in cybersecurity is preventing unknowns which evolve from time to time. Internet of Things (IoT) is one of the emerging fields that have been applied for smart cities and industries. The promises of IoTs could be confronted with the growth in the number and sophistication of cyberattacks. The extension of digital world into physical environment adds new attack surfaces on the existing security threats of traditional Internet. The major challenge brought about by physical connectivity of IoTs is to implement distributed security mechanisms for resource constrain of IoT devices. As an emerging architecture supporting IoT applications, fog computing can be considered to solve the resource and distribution issues in securing fog-to-things communication. Security functions and services, such as cryptography, could be offloaded to fog nodes to reduce computational and storage burdens on IoT devices. The distribution of fog nodes can also solve the scalability of cloud by reducing central processing and communications. On the other hand, lightweight cryptographic functions, such as elliptic curve cryptography, have been proved to be suitable for embedded systems. In this paper, we have analyzed security challenges in terms of cybersecurity principles and proposed a novel encryption scheme for fog-to-things communication.
Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review

Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Survivors of childhood cancer experience long-term increased SMN risk compared with the general population, with a greater than twofold increased solid tumor risk extending beyond age 40 years. There is a dose-dependent increased risk for solid tumors after radiotherapy, with the highest risks for tumors occurring in or near the treatment ﬁ eld (eg, greater than ﬁ vefold increased risk for breast, brain, thyroid, skin, bone, and soft tissue malignancies). Alkylating and anthracycline chemotherapies increase the risk for development of several solid malignancies in addition to acute leukemia/myelodysplasia, and these risks may be modi ﬁ ed by other patient characteristics, such as age at exposure and, potentially, inherited genetic susceptibility. Strategies for identifying survivors at risk and initiating long-term surveillance have improved and interventions are underway to improve knowledge about late-treatment effects among survivors and caregivers. Better understanding of treatment-related risk factors and genetic susceptibility holds promise for re ﬁ ning surveillance strategies and, ultimately, upfront cancer therapies. © 2018
Fertility Shocks and Equilibrium Marriage‐Rate Dynamics

Why did the marriage probability of single females in France after World War 1 rise 50% above its pre-war average, despite a 33% drop in the male/female singles ratio? We conjecture that war-time disruption of the marriage market generated an abnormal abundance of men with relatively high marriage propensities. Our model of matching over the lifecycle, when calibrated to pre-war data and two war-time shocks, succeeds in matching the French time path under the additional assumption of a pro-natalist post-war preference shock. We conclude that endogeneity issues make the sex ratio a potentially unreliable indicator of female marriage prospects.
Proposal and Synthesis Design of Wideband Filtering Differential Phase Shifters With a Pair of Out-of-Band Transmission Zeroes

In this paper, a new class of wideband filtering phase shifters with a pair of controllable out-of-band transmission zeroes is presented for the first time. The proposed wideband filtering differential phase shifter consists of two stub-loaded multimode resonators (SLMMR) in the main and reference branches, which can provide a constant phase shift and self-realized generalized Chebyshev filtering function with controllable transmission zeroes by properly setting the impedance ratio $R_{\mathrm {z}}$ of the loaded stub. On the one hand, the prescribed phase shift value, phase deviation, and phase shift bandwidth are deduced that basically dominated by resonant modes of SLMMR together with electrical lengths of the phase-shifting lines. On the other hand, the phase properties of transmission zeroes are systematically investigated to demonstrate that they arouse little effect on the phase shift performance, but highly improve the frequency selectivity in theoretical analysis. Based on the presented synthesis method which simultaneously considers wideband phase shift and bandpass filtering function, the circuit parameters of the entire proposed phase shifter can be synthesized with prescribed phase shift value, phase deviation, bandwidth, return loss, and transmission zero positions. Besides, the phase shift and return loss bandwidth can be determined in the design process. As design examples, two 90° wideband filtering phase shifters with different specifications are synthesized, designed, and fabricated to validate our proposed approach.
The Virtuous Circle: A Grounded Theory Exploration of the Good Lives Model

Sexual offenses evoke strong emotional responses and frequently elicit demands from society that offenders be indefinitely incarcerated or treated until they are deemed safe, which may impact the provision of therapeutic treatment for offenders. However, in recent years, there has been a proposal to move toward a positive, strengths-based treatment approach, namely the Good Lives Model (GLM). The present study used semi-structured interviews and a constructivist grounded theory approach to examine the experience of 13 men who were voluntarily engaging in or had completed a GLM community-based treatment program. A conceptual model emerged which outlines the process the men underwent, the factors they identified as crucial for change, and the perceived gains. The model extends previous work by exploring the process from the clients’ perspective. Implications for future research, prevention, and treatment are discussed.