Miracle-dz/UniFAR-FTUs huggingface dataset:
Framing the onset of lung cancer biographically: narratives of continuity and disruption

Most patients are diagnosed with advanced lung cancer despite the presence of many and intense symptoms at diagnosis. This qualitative study aims to explore how people with inoperable lung cancer frame and conceptualize the onset of their sickness, to obtain knowledge which might facilitate earlier health care contact for people with potential lung cancer. Patients with inoperable lung cancer were recruited through a larger longitudinal study of 400 patients recruited consecutively from two university hospitals. The narrative analysis presented here is based on 91 narrative segments derived from audio‐taped and transcribed qualitative interviews with 37 patients who survived the first year post diagnosis, complemented with data from previous interviews with the same people. Findings indicate a wide array of bodily experiences leading to diagnosis, including symptoms seen as related to other disorders, systemic complaints not conceptualized as symptoms or indications of a serious problem, and more rarely, symptoms triggering immediate action. In addition to the ‘biographical disruption’ often associated with chronic illness, this analysis indicates an alternative or parallel process involving ‘biographical continuity’, allowing for integration of past and present aspects of patients' lives. Copyright © 2006 John Wiley & Sons, Ltd.
Molecular and Optical Properties of Tree-Derived Dissolved Organic Matter in Throughfall and Stemflow from Live Oaks and Eastern Red Cedar

Studies of dissolved organic matter (DOM) transport through terrestrial aquatic systems usually start at the stream. However, the interception of rainwater by vegetation marks the beginning of the terrestrial hydrological cycle making trees the headwaters of aquatic carbon cycling. Rainwater interacts with trees picking up tree-DOM, which is then exported from the tree in stemflow and throughfall. Stemflow denotes water flowing down the tree trunk, while throughfall is the water that drips through the leaves of the canopy. We report the concentrations, optical properties (light absorbance) and molecular signatures (ultrahigh resolution mass spectrometry) of tree-DOM in throughfall and stemflow from two tree species (live oak and eastern red cedar) with varying epiphyte cover on Skidaway Island, Savannah, Georgia, USA. Both stemflow and throughfall were enriched in DOM compared to rainwater, indicating trees were a significant source of DOM. The optical and molecular properties of tree-DOM were broadly consistent with those of DOM in other aquatic ecosystems. Stemflow was enriched in highly colored DOM compared to throughfall. Elemental formulas identified clustered the samples into three groups: oak stemflow, oak throughfall and cedar. The molecular properties of each cluster are consistent with an autochthonous aromatic-rich source associated with the trees, their epiphytes and the microhabitats they support. Elemental formulas enriched in oak stemflow were more diverse, enriched in aromatic formulas, and of higher molecular mass than for other tree-DOM classes, suggesting greater contributions from fresh and partially modified plant-derived organics. Oak throughfall was enriched in lower molecular weight, aliphatic and sugar formulas, suggesting greater contributions from foliar surfaces. While the optical properties and the majority of the elemental formulas within tree-DOM were consistent with vascular plant-derived organics, condensed aromatic formulas were also identified. As condensed aromatics are generally interpreted as deriving from partially combusted organics, some of the tree-DOM may have derived from the atmospheric deposition of thermogenic and other windblown organics. These initial findings should prove useful as future studies seek to track tree-DOM across the aquatic gradient from canopy roof, through soils and into fluvial networks.
Functional Attachment of Soft Tissues to Bone : Development , Healing , and Tissue Engineering

Connective tissues such as tendons or ligaments attach to bone across a multitissue interface with spatial gradients in composition, structure, and mechanical properties. These gradients minimize stress concentrations and mediate load transfer between the soft and hard tissues. Given the high incidence of tendon and ligament injuries and the lack of integrative solutions for their repair, interface regeneration remains a significant clinical challenge. This review begins with a description of the developmental processes and the resultant structure-function relationships that translate into the functional grading necessary for stress transfer between soft tissue and bone. It then discusses the interface healing response, with a focus on the influence of mechanical loading and the role of cell-cell interactions. The review continues with a description of current efforts in interface tissue engineering, highlighting key strategies for the regeneration of the soft tissue–to-bone interface, and concludes with a summary of challenges and future directions. 201 A nn u. R ev . B io m ed . E ng . 2 01 3. 15 :2 01 -2 26 . D ow nl oa de d fr om w w w . a nn ua lr ev ie w s. or g by C ol um bi a U ni ve rs ity o n 01 /2 9/ 14 . F or p er so na l u se o nl y. BE15CH10-Lu ARI 13 June 2013 12:18
PENGARUH MANAJEMEN ASET TERHADAP OPTIMALISASI ASET TETAP PEMERINTAH KABUPATEN JAYAPURA

This research aims to analyze the influence of asset management on the level of optimizing fixed assets (land and building) in local governments of Jayapura regency. Using purposive sampling method the sample to this research is 48 respondents. The variables are assets inventory, legal audit assets, asset valuation, and supervision and assets control. According to the results using the multiple linear regression showed that individually inventory assets proven has a positive and significant impact on optimizing fixed assets (land and building) which means in accordance with hypothesis, individually legal audit assets not proved has a positive and significant impact on the level of optimizing assets fixed (land and building) which means not in accordance with hypothesis, individually asset valuation proven have had a positive and significant impact on the level of optimizing assets fixed (land and building), supervision and control assets proven have positive and significant impact on the level of optimizing assets fixed (land and building). While the simultaneous analysis results show that the four variables namely inventory of assets, audit legal assets, asset valuation, supervision and assets control proved significant / give positive response to the level of fixed ground asset optimality (land and building) this is proven by the value of F count > F table. Keyword: assets inventory, assets legal audit, assets valuation, assets supervision and control, optimizing fixed assets (land and building).
Indian shopper motivation to use artificial intelligence

PurposeThe purpose of this paper is to understand motivation of young consumers to use artificial intelligence (AI) tools such as chatbots, voice assistants and augmented reality in shopping by generating Vroom’s expectancy theory of motivation using grounded theory approach.Design/methodology/approachGrounded theory approach has been used to develop the Vroom’s expectancy theory. Initially data were collected through participant interviews using theoretical sampling. These data were analyzed and coded using the three step process, i.e. open coding, axial coding and selective coding. The categories created during coding were integrated to generate Vroom’s expectancy theory of motivation.FindingsThe findings indicate that Vroom’s expectancy theory of motivation can be used to explain motivation of young consumers to use AI tools as an aid in taking shopping decisions. The motivation may be intrinsic motivation, extrinsic motivation or force choice motivation. Expectancy represents the ease of using the tools, instrumentality represents competence of tools in performing desired tasks while valence represents satisfaction, rewarding experience and trust in using of tools.Research limitations/implicationsThe findings of the study are based on grounded theory approach which is an inductive approach. Alternate research methodologies, both inductive and deductive, need to be employed to strengthen the external validity and generalize the results. The study is limited to shopping motives of young consumers in India. A comparison with other consumer motivational studies has not been done. Hence no claim is made regarding the advantage of Vroom’s theory over other motivational theories.Practical implicationsThe study has strong implications for retailers in developing countries which are seen as an emerging market for retail and have introduced AI tools in recent years. The Vroom’s expectancy theory will help retailers to understand consumer motivation in using AI tools or shopping.Originality/valueVroom’s expectancy theory to understand consumer motivation to use AI tools in shopping was generated using the grounded theory approach.
Tactic responses to pollutants and their potential to increase biodegradation efficiency

A significant number of bacterial strains are able to use toxic aromatic hydrocarbons as carbon and energy sources. In a number of cases, the evolution of the corresponding degradation pathway was accompanied by the evolution of tactic behaviours either towards or away from these toxic carbon sources. Reports are reviewed which show that a chemoattraction to heterogeneously distributed aromatic pollutants increases the bioavailability of these compounds and their biodegradation efficiency. An extreme form of chemoattraction towards aromatic pollutants, termed ‘hyperchemotaxis’, was described for Pseudomonas putida DOT‐T1E, which is based on the action of the plasmid‐encoded McpT chemoreceptor. Cells with this phenotype were found of being able to approach and of establishing contact with undiluted crude oil samples. Although close McpT homologues are found on other degradation plasmids, the sequence of their ligand‐binding domains does not share significant similarity with that of NahY, the other characterized chemoreceptor for aromatic hydrocarbons. This may suggest the existence of at least two families of chemoreceptors for aromatic pollutants. The use of receptor chimers comprising the ligand‐binding region of McpT for biosensing purposes is discussed.
Streptomycin Accumulation in Susceptible and Resistant Strains of Escherichia coli and Pseudomonas aeruginosa

Streptomycin accumulation by susceptible strains of Escherichia coli and Pseudomonas aeruginosa has been shown to be prevented or inhibited by inhibitors of electron transport, sulfhydryl groups and protein synthesis, and agents that uncouple oxidative phosphorylation. Streptomycin is recovered from cells in an unchanged form and is intracellularly concentrated above extracellular concentrations. Accumulation kinetics are multiphasic; an initial phase which cannot be prevented by the above inhibitors is unable to cause inhibition of cell growth or loss of cell viability. Prevention of further phases of uptake does prevent these events. Inhibitor-susceptible accumulation is time dependent and begins almost immediately upon exposure of cells to streptomycin. Streptomycin accumulation remains energy dependent even when cells are losing acid-soluble [3H]adenine, presumably through loss of permeability control. These results demonstrate that streptomycin accumulation necessary for inhibition of cell growth or cell death requires energy and is not a process of diffusion or secondary to membrane leakage. Streptomycin accumulation in ribosomally resistant mutants of E. coli and P. aeruginosa is similar in that both energy-independent and energy-dependent accumulation can be demonstrated. The total energy-dependent accumulation is, however, significantly lower than that in streptomycin-susceptible cells due to the absence of an additional energy-dependent phase of accumulation, which seems dependent on ribosomal binding of streptomycin. Ribosomally resistant strains can be shown to concentrate streptomycin accumulated by the energy-dependent process above the external concentration in nutrient broth but not in Trypticase soy broth. The energy-dependent accumulation can be saturated in the Strr strain of E. coli in nutrient broth, implying limited accumulation sites.
Crises through the consumer lens: the role of trust, blame and risk

Purpose This paper aims to examine consumer reactions during product-harm crises by measuring the impact of perceived risk, blame and trust on consumer purchase intentions. Moreover, the role of perceived crisis severity is examined as affecting the three main endogenous variables of the conceptual framework. Design/methodology/approach The study uses the real-scenario approach for empirically testing the proposed conceptual framework. Participants were called to assess the story of a defective product (i.e. a soother that was recently recalled). Findings Results of the equation modeling demonstrate that perceived severity significantly influence trust and blame while it does not affect perceived risk. In addition, trust, blame and perceived risk notably affect purchase intentions. Practical implications Based on the study’s results, companies could implement appropriate strategies for reducing the negative consequences of a product-harm crisis. Originality/value The paper presents four key originality traits: Crisis management from the consumer perspective has received little attention. The relationship between trust, perceived risk and purchase intentions has not been explored in the crisis management field. Attribution of blame is a new variable added to the perceived risk-trust-purchase intention model. Perceived severity is examined as a moderator affecting the main endogenous variables of the conceptual framework.
Atypical apoptosis in L929 cells induced by evodiamine isolated from Evodia rutaecarpa

Two alkaloids, evodiamine and rutaecarpine, isolated from the dried fruits of Evodia rutaecarpa Bentham were evaluated in vitro for antiproliferation activity on tumor cells versus human peripheral blood mononuclear cells (PBMC). Evodiamine had more potent cytotoxic effects on five tumor cell lines (human malignant melanoma A375-S2, human cervical cancer HeLa, human breast adenocarcinoma MCF7, human acute monocytic leukemia THP-1, murine fibrosarcoma L929) than rutaecarpine. Moreover, evodiamine did not affect PBMC viability for a 36 h culture period. Although apoptotic bodies were observed in evodiamine-treated L929 cells stained with Hoechst 33258, DNA fragmentation as a hallmark of apoptosis was not found. Caspases were involved in the protection of L929 cells against cell death. Evodiamine initiated atypical apoptosis in L929 cells by cycle arrest at the G0/G1 phase.
The Effects of Diabetes Mellitus on Ovarian Injury and Reserve: An Experimental Study

Objective: The study aims to investigate the effects of diabetes mellitus (DM) on ovarian injury and reserve in a rat model. Study Design: In this prospective experimental study, 16 female Sprague-Dawley albino rats (12 weeks, 220-240 g) were randomly divided into 2 groups. Group 1 included 8 normal healthy rats as controls. No drug was administered to the controls. Group 2 included the other 8 rats in which diabetes was induced by intraperitoneal injections of streptozotocin (STZ). After overt DM occurred (blood glucose >250 mg/dl), all the animals were euthanized and blood samples were collected by cardiac puncture for biochemical analysis. Bilateral oophorectomy was performed for histopathological examination. Immunoexpressions of nuclear factor-kappa B (NF-kB) and caspase-3 as well as anti-Müllerian hormone (AMH) levels were assessed. Values were analyzed by t test. Results: Immunoexpressions of NF-kB and caspase-3 were significantly higher in non-treated diabetic rats than in the control group (p = 0.011 and p = 0.010, respectively). In healthy control group, AMH levels (3.22 ± 0.58 ng/ml) were significantly higher than in the non-treated diabetic group (1.41 ± 0.25 ng/dl; p = 0.024). Conclusion: Hyperglycemia causes severe ovarian injury via NF-kB pathway and caspase-3 apoptotic pathway, leading to the decrease in ovarian reserve in STZ-induced diabetic rats.
Management for resilience : the case of the North Cyprus construction industry

This thesis aims to understand how owner-managers of SMEs in a developing country manage their organizations in a turbulent environment, and how they seek to create resilience in their organizations in this context. Specifically, this thesis investigates the major factors influencing the management strategies of infrastructure construction sector SMEs in North Cyprus. The primary data for the research was collected from owner-managers of infrastructure construction SMEs in North Cyprus that held a Class-1 classification in the sector, allowing them to participate in infrastructure projects in North Cyprus. Twelve SMEs with Class-1 classification are identified in the Building Construction Association of North Cyprus (CT-BCA), of which nine out of twelve consented to participate in the research. A qualitative research approach was adopted, with primary data gathered through face-to-face semi-structured interviews with these owner-managers; the collected data was then subjected to thematic analysis. The research found that the most influential factors influencing the management strategies of SMEs in North Cyprus were the macro characteristics of the socio-political environment, the individual characteristics of the owner-managers, and the characteristics of the infrastructure construction sector itself. These factors, which are linked in deep and nuanced ways, were discovered to impact the perceptions of the owner-managers and to affect their approaches towards the management of their SMEs. By evaluating the interaction between these factors, this research identified that infrastructure construction SMEs in North Cyprus operate in a complex system, where the approach to their management is identified as dissipative. Overall, the findings indicate that SMEs in North Cyprus take a reactive approach to management within this complex system, an approach that is itself related to ever-changing relationships between the key individual and environmental factors mitigating owner-managers’ personal, sectorial and wider country circumstances. In this complex context, these SMEs cannot follow a systematic approach to management. Therefore, the resilience of these SMEs is found to lie in the adaptation of management strategies of SME owner-managers in the presence of disturbances, by experimenting and adjusting themselves in the existence of disturbances throughout their history.
Interférences d'accès multiples et performances d'un système impulsionnel à bande ultra large transposé à 60 GHz en réseau ad hoc

L'objectif de ce travail est d'etudier les performances d'un systeme radio impulsionnel a bande ultra large transpose dans la bande millimetrique pour des reseaux ad hoc. Les contraintes imposees sont la simplicite des architectures, la souplesse d'utilisation et l'asynchronisme des utilisateurs. Dans un premier temps, nous procedons a une modelisation statistique du canal a partir de mesures effectuees a l'IEMN dans la bande 57-59 GHz. L'etude du canal se decompose en deux parties. La premiere concerne l'etude de la puissance recue en environnement ad hoc. La deuxieme se focalise sur l'effet des trajets reflechis. Nous proposons ensuite un algorithme de simulation du canal et du systeme UWB choisi afin de determiner les performances du systeme en terme de taux d'erreurs binaires et de probabilite d'erreur par paquet. Un des facteurs limitant les performances est l'interference d'acces multiples (MAI). Nous effectuons une etude sur la nature de ces interferences. Trois techniques d'estimation sont proposees pour modeliser leur densite de probabilite. La premiere est une estimation non parametrique par la methode du noyau. La seconde est la distribution gaussienne generalisee et la derniere est la distribution a-stable. Les performances des trois approches ainsi que l'impact des conditions materielles et reseaux sur le MAI sont presentees. Ensuite, en utilisant une demonstration analytique, nous montrons que la modelisation du MAI par la distribution a-stable dans le cas des reseaux ad hoc est tout a fait adaptee. Enfin, nous concluons que le recepteur gaussien n'est pas optimal. S'il est difficile d'envisager la mise en œuvre d'un recepteur optimal car nous n'avons pas d'expression analytique exacte pour la densite de probabilite du MAI, un recepteur Cauchy s'avere nettement plus performant que le recepteur gaussien.
An Empirical Investigation of the Relationships Between Service Quality, Satisfaction and Behavioral Intentions among Visitors to a Wildlife Refuge

A model was developed in which quality of performance and quality of experience were conceptualized as direct antecedents of overall service quality and visitor satisfaction, which influence behavioral intentions. Eight hypotheses postulating the interrelationships between these five constructs were tested using structural equation modeling. Data for the study were collected from 282 visitors to a wildlife refuge. Seven of the eight hypotheses were supported. Results verified the existence of service quality and visitor satisfaction at both the transaction and global levels. At the transaction level, service quality (i.e. quality of performance) contributed to visitor satisfaction (i.e. quality of experience); while at the global level, visitor satisfaction influenced service quality. Both overall service quality and overall visitor satisfaction were found to directly influence visitors' future behavioral intentions, and were confirmed as being different constructs.
Prognostic signs in the evaluation of patients with minor head injury

To assess signs that might be used in the decision whether or not to admit a patient with minor head injury, the records of 713 female and 1163 male patients were reviewed. Skull radiographs were not obtained routinely; all patients were able to walk and talk when they reached medical contact. Nine patients developed an intracranial complication. The risk of developing such a complication was 16·7 per cent when the patient was agitated, 3·4 per cent in the presence of impaired consciousness and 2·1 per cent when positive neurological signs were observed at the time of examination. Based on the medical history, amnesia for >5 min and vomiting were associated with a risk of 3·3 and 1·2 per cent respectively; the risk increased considerably in the presence of both. It is recommended that all patients presenting themselves with one or more of the above symptoms or signs, or with alcohol intoxication, after a minor head injury be admitted for observation. If these guidelines had been used, all patients with an intracranial complication would have been detected, and 44·5 per cent of the bed‐days used would have been saved.