Miracle-dz/UniFAR-FTUs huggingface dataset:
Signalment factors, comorbidity, and trends in behavior diagnoses in cats: 736 cases (1991-2001).

OBJECTIVE To describe trends in behavior diagnoses from 1991 to 2001; assess the relationship between diagnoses and age, sex, reproductive status, and breed; and evaluate associations between diagnoses within the same cat (comorbidity). DESIGN Retrospective case series. ANIMALS 736 cats. PROCEDURES Medical records were reviewed for species, breed, sex, reproductive status, consultation year, birth date, and diagnoses. RESULTS The caseload decreased over the course of the study. Aggression toward people increased, and spraying decreased. Cases involving Siamese cats decreased over time. Siamese cats were evaluated more often than expected in general and specifically for aggression and ingestive behavior problems, whereas Persian cats were evaluated more often than expected for elimination outside of the litter box. Domestic shorthair cats were evaluated less often than expected in general and specifically for aggression, ingestive behavior problems, and house soiling. Male cats were overrepresented. Cats with ingestive behavior problems were evaluated at a median age of 1.5 years, compared with cats with other problems (median age, 5.5 years). Certain diagnoses were clustered, with a mean of 1.2 diagnoses/cat. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that in cats, behavior problems changed over the course of the study, age and breed distributions varied among diagnoses, and certain diagnoses were likely to occur together.
Association Between Preoperative Nutritional Status and Postoperative Outcome in Head and Neck Cancer Patients

ABSTRACT Head and neck cancer patients treated with surgery often experience significant postoperative morbidities. Administering preoperative nutritional intervention may improve surgical outcomes, but there is currently a paucity of data reviewing the association between preoperative nutritional status and postoperative outcome. It is therefore of importance to investigate this association among head and neck cancer patients. To assess the association between preoperative nutritional status and postoperative outcome in head and neck cancer patients treated with surgery, a retrospective study of 70 head and neck cancer patients who were surgically treated between 2013 and 2014 in a tertiary referral head and neck surgery center in Hong Kong was conducted. Clinical data regarding preoperative nutritional status and postoperative outcome were retrieved from a computer record system. Logistic and linear regressions were used to analyze the appropriate parameters. A higher preoperative albumin level was associated with lower rates of postoperative complications and better wound healing (P < 0.05). In contrast, preoperative body mass index, hemoglobin level, and absolute lymphocyte count did not demonstrate significant associations with postoperative outcome. As high albumin levels are associated with better surgical outcome in head and neck cancer patients, preoperative intervention strategies that boost albumin levels could be considered for improving surgical outcome.
Targeting Tax Relief at Youth Employment

Le Programme canadien pour l’embauche des jeunes était une forme ciblée de subvention à l’emploi : il permettait aux entreprises d’obtenir une réduction de leurs cotisations à l’assurance emploi si les gains assurables de leurs employés de 18 à 24 ans connaissaient une augmentation nette. Dans cet article, nous analysons les effets de ce programme. En appliquant la méthode de la différence des différences à deux ensembles de données, nous concluons que le Programme a eu des impacts importants et statistiquement significatifs. La plupart de nos observations suggèrent qu’une période supplémentaire d’emploi de 2 à 2,4 semaines a résulté en une réduction globale du nombre de sans-emploi, avec tout au plus un modeste changement dans le taux de chômage. Plusieurs effets estimés sont plus importants chez les hommes que chez les femmes. Nous observons en particulier qu’il n’y a eu aucun effet de déplacement (c’est-à-dire le remplacement, par des jeunes, de travailleurs légèrement plus a˜gés ne donnant pas droit à la subvention). Toutefois, il y a peut-être eu une diminution de la fréquentation de l’école à temps plein dans le groupe ciblé. Canada’s Youth Hires program was a targeted employment subsidy that rebated employment insurance premiums to employers with net increases in insurable earnings for youths aged 18–24 years. Using a difference-in-differences approach, in each of two data sets statistically and economically significant employment impacts are observed. Most of the evidence suggests that the 2–2.4 weeks of increased employment resulted from an aggregate reduction in those not in the labour force, with at most a modest change in the unemployment rate. Many estimated effects are larger for men than for women. Notably, strong evidence of displacement (substitution away from slightly older non-subsidized workers) is not observed. However, there may be a small reduction in full-time schooling for the targeted group.
Psychogenic Cough Tic in Children and Adolescents

cents who missed weeks, even months, of school because of psychogenic cough tics. ’ Tics are sudden, quick, involuntary and frequently repeated movements of circumscribed groups of In most of our cases,. diagnosis was delayed several weeks to several months, because the physicians did not know about this psychogenic entity. latrogenic trauma to each child was considerable, and the cost in terms of money, school time wasted and parental concern is ~n~~~i~~h~e. We briefly summarize, our. cases, review the sparse literature, and discuss the need for earlier c~~i~. ~nt~~i~ c~~ th~~ ~~e~cc~i~~~~ie ~~~it~* ;
Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives.

To identify low penetrance susceptibility alleles for colorectal cancer (CRC), we genotyped 1467 non-synonymous SNPs mapping to 871 candidate cancer genes in 2575 cases and 2707 controls. nsSNP selection was biased towards those predicted to be functionally deleterious. One SNP AKAP9 M463I remained significantly associated with CRC risk after stringent adjustment for multiple testing. Further SNPs associated with CRC risk included several previously reported to be associated with cancer risk including ATM F858L [OR=1.48; 95% confidence interval (CI): 1.06-2.07] and P1054R (OR=1.42; 95% CI: 1.14-1.77) and MTHFR A222V (OR=0.82; 95% CI: 0.69-0.97). To validate associations, we performed a kin-cohort analysis on the 14 704 first-degree relatives of cases for each SNP associated at the 5% level in the case-control analysis employing the marginal maximum likelihood method to infer genotypes of relatives. Our observations support the hypothesis that inherited predisposition to CRC is in part mediated through polymorphic variation and identify a number of SNPs defining inter-individual susceptibility. We have made data from this analysis publicly available at http://www.icr. ac.uk/research/research_sections/cancer_genetics/cancer_genetics_teams/molecular_and_population_genetics/software_and_databases/index.shtml in order to facilitate the identification of low penetrance CRC susceptibility alleles through pooled analyses.
Simple epidemiological model predicts the relationships between prevalence and abundance in ixodid ticks

We tested whether the prevalence of ticks can be predicted reliably from a simple epidemiological model that takes into account only mean abundance and its variance. We used data on the abundance and distribution of larvae and nymphs of 2 ixodid ticks parasitic on small mammals (Apodemus agrarius, Apodemus flavicollis, Apodemus uralensis, Clethrionomys glareolus and Microtus arvalis) in central Europe. Ixodes trianguliceps is active all year round, occurs in the study area in the mountain and sub-mountain habitats only and inhabits mainly host burrows and nests, whereas Ixodes ricinus occurs mainly during the warmer seasons, occupies a large variety of habitats and quests for hosts outside their shelters. In I. ricinus, the models with k values calculated from Taylor's power law overestimated prevalences. However, if moment estimates of k corrected for host number were used instead, expected prevalences of both larvae and nymphs I. ricinus in either host did not differ significantly from observed prevalences. In contrast, prevalences of larvae and nymphs of I. trianguliceps predicted by models using parameters of Taylor's power law did not differ significantly from observed prevalences, whereas the models with moment estimates of k corrected for host number in some cases under-estimated relatively lower larval prevalences and over-estimated relatively higher larval prevalences, but predicted nymphal prevalences well.
A Population-Based Study of Fish Allergy in the Philippines, Singapore and Thailand

Background: Fish allergy is the third most common food allergy after milk and egg in parts of Europe, but there is little data about prevalence in South East Asia where it is an important part of regular diets. Objective: We aimed to obtain an estimate of the population prevalence of fish allergy among older children in the Philippines, Singapore and Thailand. Methods: The population prevalence of fish allergy in 14- to 16-year-old children in the 3 countries was evaluated using a structured written questionnaire which was distributed to students of randomly selected secondary schools. An extended questionnaire to determine convincing fish allergy on the basis of typical clinical manifestations within 2 h of ingestion was administered to those with positive responses. Results: From acohort of 25,842 students, responses were 81.1% in the Philippines (n = 11,434), 67.9% in Singapore (n = 6,498) and 80.2% (n = 2,034) in Thailand. Using criteria for convincing food allergy, fish allergy was much higher in the Philippines [2.29%, 95% confidence interval (CI) 2.02–2.56] than in Singapore (0.26%, 95% CI 0.14–0.79) and Thailand (0.29%, 95% CI 0.06–0.52). Weighted multiple logistic regression analyses showed that compared to the Philippines, prevalence rates were lower in Singapore [odds ratio (OR) 0.40, 95% CI 0.27–0.60, p < 0.0001] and Thailand (OR 0.13, 95% CI 0.05–0.33, p < 0.0001). Females were more likely to have fish allergy compared to males for all children combined (OR 1.32, 95% CI 1.11–1.58, p = 0.002). Most allergies appeared mild, as only 28% of cases sought medical consultation at the time of the reaction and 31.2% of cases reported continued exposure despite allergic symptoms. Conclusion: Fish allergy in late childhood is more common in the Philippines compared to Singapore and Thailand. Differences in food processing, dietary habits and other cultural practices might be important risk factors for the development of fish allergy in these populations.
Resistance to antibiotics in urinopathogenic bacteria isolated in patients attending Kenyatta University Health Clinic, Nairobi.

OBJECTIVE To determine the aetiological bacterial agents of urinary tract infections, within communities in Kenyatta University, and current resistance levels to commonly available therapeutic agents. DESIGN Cross-sectional survey research design. SETTING Kenyatta University Health Services Clinic, Nairobi. SUBJECTS Outpatients with symptoms of urinary tract infection within the six months study duration were observed. RESULTS Females were particularly prone to have confirmed cases of UTI. Escherichia coli were the principle aetiological agent accounting for 61.7% of the isolates. Other bacterial agents were Enterobacter agglomerans (18.7%), Citrobacter diversus (4%), Klebsiella pneumoniae (3.3%), Proteus spp. (2.1%), Pseudomonas spp. (0.1%), Staphylococcus saprophyticus (9.3%), and Streptococcus feacalis (0.7%). Over 60% of the Gram negative bacterial isolates were resistant to cotrimoxazole and ampicillin, 39% resistant to augmentin and 25% were resistant to nalidixic acid. The ceftazidime was the most efficacious antimicrobial with an Escherichia coli resistance level of 2.2% (P=0.05). Resistance to nitrofuraintoin, gentamicin, cefuroxime, norfloxacin and ciprofloxacin was demonstrated in less than 15% of the bacterial isolates. CONCLUSION The cephalosporins, fluoroquinolones, nitrofurantoin and gentamicin have good efficacy against the uropathogenic bacteria and may be good therapeutic choices when culture results are unavailable. High resistance levels exist against cotrimoxazole, ampicillin, augmentin, and nalidixic acid. These later antibiotics should therefore be used against the uropathogenic bacteria with caution.
DDGP versus SMILE in Newly Diagnosed Advanced Natural Killer/T-Cell Lymphoma: A Randomized Controlled, Multicenter, Open-label Study in China

Purpose: Optimal treatment strategies for advanced natural killer/T (NK/T)-cell lymphoma have not been fully defined. We compared the safety and efficacy of DDGP and SMILE regimens for advanced NK/T-cell lymphoma in a randomized controlled, multicenter, and open-label clinical trial. Experimental Design: Patients were newly diagnosed in stages III–IV and had performance scores in 0 to 2. Six cycles of DDGP (dexamethasone, cisplatin, gemcitabline, and pegaspargase) or SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) chemotherapy were randomly assigned to them. The primary end point was progression-free survival (PFS). Secondary end points included response rate and overall survival (OS). The trial is ongoing and is registered with ClinicalTrials.gov (No. NCT01501149). Results: Of 42 patients enrolled, 21 were treated with DDGP therapy, and 21 patients were treated with SMILE therapy. The 1-year PFS and 2-year OS rates were better in the DDGP group than that in the SMILE group (86% vs. 38% for 1-year PFS, P = 0.006; 74% vs. 45% for 2-year OS, P = 0.027). Complete remission (CR) rate and overall response rate (ORR) of the DDGP group were higher than that in the SMILE group (71% vs. 29%, P = 0.005 for CR rate; 95% vs. 67%, P = 0.018 for ORR). The SMILE group showed more serious leucopenia (P = 0.030) and severe allergic reaction (P = 0.015) than the DDGP group. In addition, two cases in the SMILE group underwent grade 4 mucosal reaction. Conclusions: DDGP chemotherapy resulted in significant improvement in PFS, OS, and better tolerability compared with SMILE chemotherapy for newly diagnosed advanced NK/T-cell lymphoma patients. Clin Cancer Res; 22(21); 5223–8. ©2016 AACR.
House Prices, Mortgage Debt, and Labor Mobility

Using detailed credit and employment data for the United States, we estimate the effect of mortgage debt on labor mobility. We find a robust negative relation between the loanto-value ratio (LTV) on the primary residence and labor mobility. Individuals with negative home equity are 3.6 percentage points less likely to move in a year. This effect is stronger for sub-prime and liquidity-constrained borrowers. We also find that diminished labor mobility owing to higher LTVs depresses labor income growth, especially for individuals with less access to liquidity and longer tenure in their current job. Consistent with a housing-lock explanation, we find that individuals with higher LTVs have higher intra-ZIPcode job mobility. Overall we document signicant spillover from the housing market to the labor market. ** PLEASE DO NOT CITE OR CIRCULATE WITHOUT PERMISSION ∗Comments welcome. We are deeply grateful to “The Provider” for supporting the research and allowing us access to their data. We thank the Wells Fargo Center for Finance and Accounting Research and Center for Research in Economics and Strategy and the Olin Business School for financial support. For helpful comments, we thank Naser Hamdi and Stephanie Cummings. Authors are from the Olin Business School at Washington University in St Louis and can be reached at gopalan@wustl.edu, hamilton@wustl.edu, ankitkalda@wustl.edu and dsovich@wustl.edu.
Contamination Levels and Identification of Bacteria in Milk Sampled from Three Regions of Tanzania: Evidence from Literature and Laboratory Analyses

Milk in Tanzania has been reported to be contaminated with large number of bacteria. This is because (1) milk is obtained from animals with unknown health status, (2) good milking and handling practices are to a large extent not observed, and (3) marketing and distribution are done in informal channels. These factors are potential causes of milk-borne diseases and milk quality loss. The aim of this study was to assess nutritional risks in milk as reported in literature over a period of 20 years and through analyses of samples collected during the present study. The issues highlighted in literature were high bacteria and coliform counts exceeding standard levels in East Africa, prevalence of bacteria and drug residues in milk, and adulteration. Based on performed analyses, total bacterial count 1.0 × 107 colony forming units per millilitre (cfu/ml) and total coliform count 1.1 × 107 cfu/ml, also greater than recommended levels, were found. Ten bacteria types were isolated from milk samples (five, Pseudomonas aeruginosa, Listeria monocytogenes, Listeria innocua, Listeria ivanovii, and Klebsiella spp. are reported in Tanzanian for the first time). Two drugs tetracycline and sulphur were detected. Therefore, it is worth noting that integrated research is needed to evaluate the situation and address these challenges.
Contrasting impacts of reindeer grazing in two tundra grasslands

Plant communities in Arctic and alpine areas are changing due to higher temperatures and longer vegetation periods and it is uncertain how this will affect plant-herbivore dynamics. For instance, relatively fast-growing, deciduous shrub species that are the most responsive to warming may also be the most targeted by herbivores such as reindeer, giving less palatable evergreen shrubs the chance to expand. Using herbivore exclosures, we have studied how two grasslands with contrasting nutrient and moisture regimes, a dry, nutrient-poor alpine grass heath and a wet, productive low herb meadow, changed between 1995 and 2012, in grazed and ungrazed conditions. At the grass heath, evergreen low shrub abundance had more than doubled, regardless of grazer treatment, whereas at the low herb meadow, evergreen shrubs had increased only outside exclosures while deciduous tall shrubs and forbs were significantly more abundant inside exclosures. Deciduous tall shrubs were also significantly taller in exclosures. These contrasting findings suggest that the impact of herbivores is to a great deal determined by their influence on competitive interactions between plant species, and therefore depends on the underlying composition of the plant community. Consequently, as the balance in these competitive interactions is shifting due to climate warming, we conclude that the potential of herbivory to influence this balance is considerable yet highly site dependent.
Insulin and Cardiovascular Disease: Paris Prospective Study

The Paris Prospective Study is a long-term investigation of coronary heart disease (CHD) risk factors in a large population of working men. The baseline cohort included 7028 men, 6093 who had a 75-g oral glucose tolerance test with measurement of plasma insulin and glucose levels (0 and 2 h) and 125 who were known non-insulin-treated diabetic patients. After a mean follow-up of 11 yr, 126 deaths ascribed to CHD were reported. Major independent predictors of CHD death were blood pressure, smoking, plasma cholesterol level, and fasting and 2-h postload plasma insulin level. Impairment of glucose tolerance, including overt diabetes, did not rank as an independent predictor when other baseline variables were accounted for. In the subset of the baseline cohort who presented with impaired glucose tolerance or diabetes (n = 943), 26 died from CHD during the follow-up. The strongest independent predictor of subsequent CHD death in this subsample with abnormal glucose tolerance was plasma triglyceride level. In view of the accumulating evidence that hyperinsulinemia and hypertriglyceridemia generally occur in the same type of subjects, in relation to insulin resistance and central obesity, the epidemiological findings of the Paris Prospective Study and of other investigations support the hypothesis that a constellation of mild metabolic abnormalities may play a deleterious role with regard to cardiovascular disease risk.
The dialogue and advocacy initiatives for reforming the business environment of the tourism and hospitality sector in Tanzania

Purpose This paper aims to investigate the nature of the public–private dialogue (PPD) initiatives and how PPDs are being used in the tourism and hospitality sector as the tool for reforming the business environment (e.g. set policy priorities, inform policy design, improve legislative proposals and incorporate feedback into regulatory implementation). Design/methodology/approach The study adapted a descriptive-qualitative method through desk research and in-depth interviews based on the explorative research design. The respondents included tourism and hospitality stakeholders from the public and private sectors in the Arusha, Kilimanjaro and Dar es Salaam tourist destinations in Tanzania. Findings The findings revealed numerous PPD initiatives which various actors in the tourism value chain rely on to address their matters. While some initiatives are not regular forums, few have been institutionalized in the Tourism Act of 2008, while others have been prescribed from the global level (UNWTO). The well-known PPD platforms include the Tourism Facilitation Committee, Technical Advisory Committee to the Minister, Tanzania National Business Council (the Tourism Task Force) and Public–Private Partnership in Tourism under the Ministry. However, most of the existing platforms overlap in terms of subject matter, mandates, participants and timing. The key success stories and factors of the PPD initiatives and the associated challenges have been discussed. Practical implications The study provides insight to the conclusion that public policies that are designed through PPD are better conceived and more effectively implemented because they result from mutual understanding between government and the business community. This knowledge is important to the least developed countries (LDCs), like Tanzania, as research has shown that stronger and more constructive dialogue between government and the private sector leads to better business environment, and countries with better business environments grow faster, attract more investment and reduce poverty more than the opposite. Originality/value Although several PPD initiatives are taking place in the tourism sector in most developing countries, little about them has been documented in the tourism literature. Hence, this study, which focuses on Tanzania, aims to fill this knowledge gap.