Miracle-dz/UniFAR-FTUs huggingface dataset:
Low-Slow-Small (LSS) Target Detection Based on Micro Doppler Analysis in Forward Scattering Radar Geometry

The increase in drone misuse by civilian apart from military applications is alarming and need to be addressed. This drone is characterized as a low altitude, slow speed, and small radar cross-section (RCS) (LSS) target and is considered difficult to be detected and classified among other biological targets, such as insects and birds existing in the same surveillance volume. Although several attempts reported the successful drone detection on radio frequency-based (RF), thermal, acoustic, video imaging, and other non-technical methods, however, there are also many limitations. Thus, this paper investigated a micro-Doppler analysis from drone rotating blades for detection in a special Forward Scattering Radar (FSR) geometry. The paper leveraged the identified benefits of FSR mode over conventional radars, such as improved radar cross-section (RCS) value irrespective of radar absorbing material (RAM), direct signal perturbation, and high resolutions. To prove the concept, a received signal model for micro-Doppler analysis, a simulation work, and experimental validation are elaborated and explained in the paper. Two rotating blades aspect angle scenarios were considered, which are (i) when drone makes a turn, the blade cross-sectional area faces the receiver and (ii) when drone maneuvers normally, the cross-sectional blade faces up. The FSR system successfully detected a commercial drone and extracted the micro features of a rotating blade. It further verified the feasibility of using a parabolic dish antenna as a receiver in FSR geometry; this marked an appreciable achievement towards the FSR system performance, which in future could be implemented as either active or passive FSR system.
Hardware prototyping of FBMC/OQAM baseband for 5G mobile communication systems

Embedded systems in the field of digital communications are becoming increasingly diversified and complex. This trend is being confirmed with the emergence of many new application scenarios for mobile communication systems beyond 2020. In this context, rapid prototyping experiences are of high interest for performance validation and proof-of-concept of the diverse proposed communication techniques. In this paper, we present a new design and prototyping experience of an advanced communication system based on filter-bank multi-carrier (FBMC) modulation. This modulation is being studied and considered nowadays by recent research projects as a key enabler for the future flexible 5G air interface. The paper illustrates the complete design and prototyping flow from al-gorithm specification to on-board validation and demonstration. The proposed prototype enables to illustrate and evaluate the performance of this new waveform compared to state-of-the-art OFDM-based systems.
Cell-free hemoglobin augments acute kidney injury during experimental sepsis.

Acute kidney injury is a common complication of severe sepsis and contributes to high mortality. The molecular mechanisms of acute kidney injury during sepsis are not fully understood. Because hemoproteins, including myoglobin and hemoglobin, mediate kidney injury during rhabdomyolysis, we hypothesized that cell-free hemoglobin would exacerbate acute kidney injury during sepsis. Sepsis was induced in mice by intraperitoneal injection of cecal slurry (CS). To mimic elevated levels of cell-free hemoglobin (CFH) observed during human sepsis, mice also received a retro-orbital injection of CFH or control. Four groups of mice were analyzed: sham, CFH alone, CS alone, and CS+CFH. The addition of CFH to CS reduced 48-hour survival compared to CS alone (67% vs 97%, p=0.001) and increased severity of illness. After 24 and 48 hrs, CS+CFH mice had reduced glomerular filtration rate (GFR) from baseline, while sham, CFH, and CS mice maintained baseline GFR. Biomarkers of acute kidney injury, NGAL and Kim-1, were markedly elevated in CS+CFH compared to CS (8-fold for NGAL, 2.4-fold for Kim-1, p<0.002 for each) after 48 hrs. Histologic examination showed a trend towards increased tubular injury in CS+CFH exposed kidneys compared to CS. However, there were similar levels of renal oxidative injury and apoptosis in CS+CFH compared to CS. Kidney levels of pro-inflammatory cytokines were similar between CS and CS+CFH. Human renal tubule cells (HK-2) exposed to CFH demonstrated increased cytotoxicity. Together, these results show that cell-free hemoglobin exacerbates acute kidney injury in a mouse model of experimental sepsis, potentially through increased renal tubular injury.
Heartbeat Induces a Cortical Theta-Synchronized Network in the Resting State

Abstract In the resting state, heartbeats evoke cortical responses called heartbeat-evoked responses (HERs), which reflect cortical cardiac interoceptive processing. While previous studies have reported that the heartbeat evokes cortical responses at a regional level, whether the heartbeat induces synchronization between regions to form a network structure remains unknown. Using resting-state MEG data from 85 human subjects of both genders, we first showed that heartbeat increases the phase synchronization between cortical regions in the theta frequency but not in other frequency bands. This increase in synchronization between cortical regions formed a network structure called the heartbeat-induced network (HIN), which did not reflect artificial phase synchronization. In the HIN, the left inferior temporal gyrus and parahippocampal gyrus played a central role as hubs. Furthermore, the HIN was modularized, containing five subnetworks called modules. In particular, module 1 played a central role in between-module interactions in the HIN. Furthermore, synchronization within module 1 had a positive association with the mood of an individual. In this study, we show the existence of the HIN and its network properties, advancing the current understanding of cortical heartbeat processing and its relationship with mood, which was previously confined to region level.
Rumen and Fecal Microbial Community Structure of Holstein and Jersey Dairy Cows as Affected by Breed, Diet, and Residual Feed Intake

Simple Summary Dietary interventions aimed at reducing methane production may be influenced by other factors such as animal breed and feed efficiency (indicated by residual feed intake (RFI) status). We examined the rumen and fecal microbiota of Holstein and Jersey dairy cows with diverging RFI status fed diets differing in concentrate-to-forage ratio. Community differences seen in the rumen were reduced or absent in feces, except in the case of animal-to-animal variation, where differences were more pronounced. Understanding factors that influence methane production will be key to determining effective methane reduction strategies in the future. Abstract Identifying factors that influence the composition of the microbial population in the digestive system of dairy cattle will be key in regulating these populations to reduce greenhouse gas emissions. In this study, we analyzed rumen and fecal samples from five high residual feed intake (RFI) Holstein cows, five low RFI Holstein cows, five high RFI Jersey cows and five low RFI Jersey cows, fed either a high-concentrate diet (expected to reduce methane emission) or a high-forage diet. Bacterial communities from both the rumen and feces were profiled using Illumina sequencing on the 16S rRNA gene. Rumen archaeal communities were profiled using Terminal-Restriction Fragment Length Polymorphism (T-RFLP) targeting the mcrA gene. The rumen methanogen community was influenced by breed but not by diet or RFI. The rumen bacterial community was influenced by breed and diet but not by RFI. The fecal bacterial community was influenced by individual animal variation and, to a lesser extent, by breed and diet but not by RFI. Only the bacterial community correlated with methane production. Community differences seen in the rumen were reduced or absent in feces, except in the case of animal-to-animal variation, where differences were more pronounced. The two cattle breeds had different levels of response to the dietary intervention; therefore, it may be appropriate to individually tailor methane reduction strategies to each cattle breed.
In Vitro Interactions of Moroccan Propolis Phytochemical’s on Human Tumor Cell Lines and Anti-Inflammatory Properties

Propolis is a resin manufactured by bees through the mixture of plant exudates and waxes with secreted substances from their metabolism, resulting in a complex mixture of natural substances of which quality depends on the phytogeographic and climatic conditions around the hive. The present study investigated the contribution of phenolic compounds to the cytotoxic and anti-inflammatory activities of propolis. The phenolic composition was evaluated by liquid chromatography with diode-array detection coupled to electrospray ionization tandem mass spectrometry (LC/DAD/ESI-MSn) analysis after phenolic extraction. The cytotoxicity of the extracts was checked using human tumor cell lines (MCF7- breast adenocarcinoma, NCI-H460- non-small cell lung carcinoma, HeLa- cervical carcinoma, HepG2- hepatocellular carcinoma, and MM127- malignant melanoma), as well as non-tumor cells (a porcine liver primary culture-PLP2). The anti-inflammatory activity was assessed using the murine macrophage (RAW 264.7) cell line. The results showed a composition rich in phenolic acids, such as caffeic and p-coumaric acid, as well as flavonoids, such as pinocembrin, pinobanksin, and pinobanksin-3-O-butyrate. Samples MP2 from Sefrou and MP3 from Moulay Yaâcoub presented a high concentration in phenolic compounds, while MP1 and MP4 from Boulemane and Immouzzer Mermoucha, respectively, showed similar composition with low bioactivity. The higher concentration of phenolic compound derivatives, which seems to be the most cytotoxic phenolic class, can explain the pronounced antitumor and anti-inflammatory activity observed for sample MP2.
Safety and effectiveness of upadacitinib or adalimumab plus methotrexate in patients with rheumatoid arthritis over 48 weeks with switch to alternate therapy in patients with insufficient response

Background In SELECT-COMPARE, a randomised double-blind study, upadacitinib 15 mg once daily was superior to placebo or adalimumab on background methotrexate (MTX) for treating rheumatoid arthritis signs and symptoms and inhibited radiographical progression versus placebo at 26 weeks. Here we report 48-week safety and efficacy in patients who continued their original medication or were rescued to the alternative medication for insufficient response. Methods Patients on MTX received upadacitinib 15 mg, placebo or adalimumab for 48 weeks. Rescue without washout, from placebo or adalimumab to upadacitinib or upadacitinib to adalimumab occurred if patients had <20% improvement in tender joint count (TJC) or swollen joint count (SJC) (weeks 14/18/22) or Clinical Disease Activity Index (CDAI) >10 (week 26); remaining placebo patients were switched to upadacitinib at week 26. Efficacy was analysed by randomised group (non-responder imputation), as well as separately for rescued patients (as observed). Treatment-emergent adverse events per 100 patient-years were summarised. Results Consistent with responses through week 26, from weeks 26 to 48, responses by randomised group including low disease activity, clinical remission and improvements in pain and function remained superior for upadacitinib versus adalimumab; radiographical progression remained lower for upadacitinib versus placebo (linear extrapolation). Although both switch groups responded, a higher proportion of patients rescued to upadacitinib from adalimumab achieved CDAI ≤10 at 6 months postswitch versus patients rescued from upadacitinib to adalimumab. Safety at week 48 was comparable to week 26. Conclusion Upadacitinib+MTX demonstrated superior clinical and functional responses versus adalimumab+MTX and maintained inhibition of structural damage versus placebo+MTX through week 48. Patients with an insufficient response to adalimumab or upadacitinib safely achieved clinically meaningful responses after switching to the alternative medication without washout.
Increased Risk of Bone Fractures in Hemodialysis Patients Treated with Proton Pump Inhibitors in Real World: Results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Long‐term treatment with proton pump inhibitors (PPIs) is associated with an increased risk of fractures in the general population. PPIs are widely prescribed to dialysis patients but to date no study has specifically tested, by state‐of‐art statistical methods, the relationship between use of PPIs and fractures in this patient population. This study aimed to assess whether use of PPIs is associated with bone fractures (ie, hip fractures and fractures other than hip fractures) in a large international cohort of hemodialysis patients. We considered an observational prospective cohort of 27,097 hemodialysis patients from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Data analysis was performed by the Fine and Gray method, considering the competitive risk of mortality, as well as by a cause‐specific hazards Cox model with death as a censoring event and matching patients according to the prescription time. Of 27,097 hemodialysis patients, 13,283 patients (49%) were on PPI treatment. Across the follow‐up period (median, 19 months), 3.8 bone fractures × 100 person‐years and 1.2 hip fractures × 100 person‐years occurred. In multiple Cox models, considering the competitive risk of mortality, the incidence rate of bone (subdistribution hazard ratio [SHR] 1.22; 95% CI, 1.10 to 1.36; p < 0.001) and hip fractures (SHR 1.35; 95% CI, 1.13 to 1.62; p = 0.001) was significantly higher in PPI‐treated than in PPI‐untreated patients. These findings also held true in multiple, cause‐specific, hazards Cox models matching patients according to the prescription time (bone fractures: HR 1.47; 95% CI, 1.23 to 1.76; p < 0.001; hip fractures: HR 1.85; 95% CI, 1.37 to 2.50; p < 0.001). The use of PPIs requires caution and a careful evaluation of risks/benefits ratio in hemodialysis patients. © 2019 American Society for Bone and Mineral Research.
Competitiveness of Istanbul as A Tourism Destination for Luxury Market

This study aims to evaluate concept of luxury within the tourism destination competitiveness framework. In today’s world, where tough competition is prevalent, tourism destination competitiveness bears enormous significance to increase market share. In parallel, luxury is increasingly important and which has been referred to in various tourism fairs held throughout 2016.The study tries to weave together these two concepts; that is the conception of luxury with the idea of destination competitiveness (and the determining factors that it embodies). Through this combination, the study has generated a questionnaire for the evaluation of Istanbul as a luxury tourism destination. The results indicate that although Istanbul rates high in terms of endowed resources, created resources and demand, its competitiveness stands low in terms of situational conditions, supporting factors and tourism destination management. The results also help identify weak links such as security issues, political structure, and destination management, and help encourage the sector to analyze these issues that would eventually contribute to the increased competitiveness of Istanbul as a luxury destination.
Using A Soft Conformable Foot Sensor to Measure Changes in Foot Strike Angle During Running

The potential association between running foot strike analysis and performance and injury metrics has created the need for reliable methods to quantify foot strike pattern outside the laboratory. Small, wireless inertial measurement units (IMUs) allow for unrestricted movement of the participants. Current IMU methods to measure foot strike pattern places small, rigid accelerometers and/or gyroscopes on the heel cap or on the instep of the shoe. The purpose of this study was to validate a thin, conformable IMU sensor placed directly on the dorsal foot surface to determine foot strike angles and pattern. Participants (n = 12) ran on a treadmill with different foot strike patterns while videography and sensor data were captured. Sensor measures were compared against traditional 2D video analysis techniques and the results showed that the sensor was able to accurately (92.2% success) distinguish between rearfoot and non-rearfoot foot strikes using an angular velocity cut-off value of 0°/s. There was also a strong and significant correlation between sensor determined foot strike angle and foot strike angle determined from videography analysis (r = 0.868, p < 0.001), although linear regression analysis showed that the sensor underestimated the foot strike angle. Conformable sensors with the ability to attach directly to the human skin could improve the tracking of human dynamics and should be further explored.
The Impact of User Interface on Young Children's Computational Thinking

Aim/Purpose Over the past few years, new approaches to introducing young children to computational thinking have grown in popularity. This paper examines the role that user interfaces have on children’s mastery of computational thinking concepts and positive interpersonal behaviors. Background There is a growing pressure to begin teaching computational thinking at a young age. This study explores the affordances of two very different programming interfaces for teaching computational thinking: a graphical coding application on the iPad (ScratchJr) and tangible programmable robotics kit (KIBO). Methodology This study used a mixed-method approach to explore the learning experiences that young children have with tangible and graphical coding interfaces. A sample of children ages four to seven (N = 28) participated. Findings Results suggest that type of user interface does have an impact on children’s learning, but is only one of many factors that affect positive academic and socio-emotional experiences. Tangible and graphical interfaces each have qualities that foster different types of learning
Histopathology of Inner Ear Malformations: Potential Pitfalls for Cochlear Implantation.

HYPOTHESIS The presence of bony inner ear malformations may associate with a number of anatomical abnormalities affecting the middle ear structures. Those malformations may create pitfalls and complications for cochlear implantation. BACKGROUND Inner ear malformations associate with varying degrees of hearing loss, and frequently require cochlear implantation for hearing rehabilitation. Therefore, the abnormalities affecting the middle- and inner-ear structures may increase the risk of surgical complications. METHODS We examined 38 human temporal bones from donors with bony inner ear malformations. Using light microscopy, we analyzed the presence of abnormalities in the structures of the middle- and inner-ear. RESULTS Our collection comprises of 38 specimens with inner-ear malformations (cochlear aplasia, n = 3; cochlear hypoplasia, n = 30; incomplete partition, n = 3; isolated vestibular malformation, n = 2). The anatomy of the middle ear was abnormal in most temporal bones with cochlear aplasia, cochlear hypoplasia, and incomplete partition type I (40%-100%). Some of those abnormalities (hypoplastic or obliterated mastoid, 55.2%; aplastic or obliterated round window, 71.0%; aberrant course of the facial nerve, 36.8%) may hinder the access to the round window using the conventional facial recess approach for cochlear implantation. The cochlear nerve and associated bony structures (internal auditory canal and bony canal for cochlear nerve) were normal in 71.0% of all temporal bones with inner ear malformations. CONCLUSION Each different type of malformation may create specific surgical challenges to surgeons. Comprehensive preoperative imaging is fundamental toward the surgical success of cochlear implants in patients with malformations. Alternatives to circumvent those middle- and inner-ear abnormalities and potential complications are further discussed.
Ulva lactuca methanolic extract improves oxidative stress-related male infertility induced in experimental animals

Abstract Aim This study designated to investigate and compare the therapeutic effect of Ulva lactuca methanolic extract against oxidative stress (OS)-infertility induced by naturally occurring prooxidants (gossypol) and selenium- vitamins A, C, and E (selenium-ACE) drug. Methods Male infertility was induced in rat by intraperitoneal injection of 5 mg/kg gossypol eight times then the treatment was carried out with 100 mg/kg ulva methanolic extract oral administration for one or two weeks, after this period OS, and male infertile markers were detected in blood and/or testes. Results Gossypol stimulated male infertility by increasing testicular OS markers and decreasing semen quality, hyaluronidase enzyme activity, and blood testosterone level. The treatment with ulva methanolic extract improved gossypol related adverse effects. The treatment period for two weeks with extract was the most potent one. Conclusions Ulva methanolic extract could be considered as good antioxidant therapeutic candidate for OS linked male infertility.
ASHP national survey of pharmacy practice in hospital settings: Workforce-2018.

PURPOSE Results of the 2018 ASHP national survey of pharmacy practice in hospital settings pertaining to the pharmacy workforce are presented. METHODS Pharmacy directors at 4,897 general and children's medical-surgical hospitals in the United States were surveyed using a mixed-mode method of contact by mail and email. Survey completion was online. IMS Health supplied data on hospital characteristics; the survey sample was drawn from the IMS hospital database. RESULTS The survey response rate was 16.6%. The results indicate that inpatient staffing has increased for both pharmacists and pharmacy technicians. More than half of the respondents reported shortages of pharmacy managers, experienced technicians, and experienced pharmacy technicians with sterile compounding experience. More than half of the respondents reported an excess of entry-level frontline pharmacists. The perceived shortage of pharmacists is in decline, while the perceived shortage of pharmacy technicians, especially those with years of experience, is increasing. Pharmacists commonly chair multidisciplinary committees within health systems, and pharmacy leaders often report directly to the chief executive officer or chief operating officer; they are often responsible for reporting quality information associated with medication use to the health system's board. The use of a pharmacist credentialing and privileging process beyond licensure has increased over the past 4 years. Attention is being devoted to stress in the work place and addressing burnout among healthcare professionals, including pharmacists. CONCLUSION The profession is fostering a workforce that is appropriate in composition, sufficient in number, and has the competence to improve the value and safety of medication use.