Miracle-dz/UniFAR-FTUs huggingface dataset:
Studying Nursing Home Innovation: The Green House Model of Nursing Home Care.

In 1997, the Pioneer Network began efforts to transform nursing homes (NHs) to settings where residents can thrive and care is resident directed (Pioneer Network 2015). Envisioned were noninstitutional, homelike settings where residents’ preferences drove care and where empowered direct care staff offered care that was compatible with residents’ preferences (Koren 2010). This transformation, commonly called “nursing home culture change,” gained recognition and momentum in response to support and advocacy from key stakeholders, including the Centers for Medicare and Medicaid Services, NH trade organizations, and state culture change coalitions (Miller et al. 2014). Early on, these and other key stakeholders reached consensus on practices integral to actualizing key components of NH culture change, including resident direction, homelike atmosphere, close relationships, staff empowerment, collaborative decision making, and implementation of quality improvement processes (Koren 2010). The movement to transformNHs can be viewed as successful as the vast majority of U.S. NHs report adopting culture change practices, at least to some extent (Miller et al. 2014). However, this view of success is tempered by the fact that change has been incremental and only a minority of facilities have achieved full transformation (Miller et al. 2014). Still, full transformation is an expectation of the comprehensive prescribed culture change models such as Planetree (Planetree 2014), the Eden Alternative (Thomas 2003), or the Green House (GH) model (Rabig et al. 2006)—the evaluation of the latter is the focus of this HSR Special Issue. As Zimmerman et al. discusses (2016), the overriding intent of the GH evaluation—The Research Initiative Valuing Eldercare ©Health Research and Educational Trust DOI: 10.1111/1475-6773.12437 SPECIAL ISSUE GREEN HOUSE MODELOF NURSING HOMECARE
Acetyl phosphate‐sensitive regulation of flagellar biogenesis and capsular biosynthesis depends on the Rcs phosphorelay

As part of our attempt to map the impact of acetyl phosphate (acetyl∼P) on the entire network of two‐component signal transduction pathways in Escherichia coli, we asked whether the influence of acetyl∼P on capsular biosynthesis and flagellar biogenesis depends on the Rcs phosphorelay. To do so, we performed a series of epistasis experiments: mutations in the components of the pathway that controls acetyl∼P levels were combined with mutations in components of the Rcs phosphorelay. Cells that did not synthesize acetyl∼P produced no capsule under normally permissive conditions, while those that accumulated acetyl∼P synthesized capsule under conditions previously considered to be non‐permissive. Acetyl∼P‐dependent capsular biosynthesis required both RcsB and RcsA, while the lack of RcsC restored capsular biosynthesis to acetyl∼P‐deficient cells. Similarly, acetyl∼P‐sensitive repression of flagellar biogenesis was suppressed by the loss of RcsB (but not of RcsA), while it was enhanced by the lack of RcsC. Taken together, these results show that both acetyl∼P‐sensitive activation of capsular biosynthesis and acetyl∼P‐sensitive repression of flagellar biogenesis require the Rcs phosphorelay. Moreover, they provide strong genetic support for the hypothesis that RcsC can function as either a kinase or a phosphatase dependent on environmental conditions. Finally, we learned that RcsB and RcsC inversely regulated the timing of flagellar biogenesis: rcsB mutants elaborated flagella prematurely, while rcsC mutants delayed their display of flagella. Temporal control of flagella biogenesis implicates the Rcs phosphorelay (and, by extension, acetyl∼P) in the transition of motile, planktonic individuals into sessile biofilm communities.
Evaluation of cholestatic jaundice in young infants.

In developing countries cholestatic jaundice occurs in young infants due to a variety of causes. Irrespective of the etiology the disease’s consequences on liver cell function are the same. Hence early recognition and treatment may prevent permanent liver damage at least in some of the patients. This study was conducted to analyze the various causes that lead to cholestatic jaundice in infants in a developing country specifically India. A complete blood picture total liver function test gamma glutamyl transpeptidase lipid profile ultrasound abdomen TORCH screening and percutaneous liver biopsy were done among 36 infants (20 males and 16 females) below 6 months of age with cholestatic jaundice. Overall cholestasis in young infants has a varied etiology including congenital infections malformations metabolic disorders and inherited functional disorders of unknown etiology. Delayed presentation was the single most important factor which resulted in the poor prognosis of cholestatic syndrome of infancy in developing countries. It is noted that 10 (neonatal hepatitis 4 idiopathic 4 hypothyroidism 1 and Bylers disease 1) out of a total of 36 had a normal liver function a minimum of 1 year after cholestasis. It is also noted that percutaneous liver biopsy is safe in young infants and is most useful for diagnosis.
Modeling robot movement in a virtual environment

Abstract This research looked at the use of robots in place of humans in urban search and rescue (USAR) missions. The success of USAR missions often rests on the ability of the human to control the robot. This study evaluated the following three control modes for USAR missioning: gamepad, keyboard, and mouse. Task completion time and error count were the performance measures used. The results suggest that for robot maneuvering which requires coordinated control of both robot movement and directing the camera, the use of a game pad achieves higher performance than the mouse or keyboard. On the other hand, for the control of robot arm movement, all three control modes perform equally well.
Pulmonary artery catheter coiled in the main pulmonary artery trunk

Pulmonary artery (PA) catheterisation has been performed for over four decades. It is utilised in intensive care units and perioperatively to titrate fluid and pressor therapy. Major and minor complications have been reported. The catheter can infrequently loop and coil in the right atrium, right ventricle and superior vena cava . We report a case of coiling of the PA catheter in the main PA. A 33-year-old woman was admitted with multiorgan failure and shock. She required mechanical ventilation, was in severe pulmonary oedema and required vasopressors for shock. We placed a PA catheter to assist in the management of her haemodynamic collapse. The catheter coiled in the main pulmonary trunk, which is extremely rare. The catheter was removed without any complications.
Leiomyosarcoma of the thyroid gland

The existence of primary thyroid sarcomas represents a contentious issue. Some authors believe that thyroid sarcomas are, in fact, anaplastic carcinomas with sarcomatous (spindle cell) features. From the standpoint of treatment and prognosis, the histogenesis of thyroid ‘sarcomas’ is academic, because these tumors, irrespective of the therapeutic intervention, are lethal 1. Primary thyroid leiomyosarcomas are extremely rare. Only nine isolated cases have been reported in the literature and such tumors carry a very poor prognosis 1, 2, 3, 4, 5, 6, 7.
Relations between White Matter Maturation and Reaction Time in Childhood

Abstract White matter matures with age and is important for the efficient transmission of neuronal signals. Consequently, white matter growth may underlie the development of cognitive processes important for learning, including the speed of information processing. To dissect the relationship between white matter structure and information processing speed, we administered a reaction time task (finger abduction in response to visual cue) to 27 typically developing, right-handed children aged 4 to 13. Magnetoencephalography and Diffusion Tensor Imaging were used to delineate white matter connections implicated in visual-motor information processing. Fractional anisotropy (FA) and radial diffusivity (RD) of the optic radiation in the left hemisphere, and FA and mean diffusivity (MD) of the optic radiation in the right hemisphere changed significantly with age. MD and RD decreased with age in the right inferior fronto-occipital fasciculus, and bilaterally in the cortico-spinal tracts. No age-related changes were evident in the inferior longitudinal fasciculus. FA of the cortico-spinal tract in the left hemisphere and MD of the inferior fronto-occipital fasciculus of the right hemisphere contributed uniquely beyond the effect of age in accounting for reaction time performance of the right hand. Our findings support the role of white matter maturation in the development of information processing speed. (JINS, 2013, 19, 1–14)
C1q/Tumor necrosis factor-related protein-3 protects macrophages against LPS-induced lipid accumulation, inflammation and phenotype transition via PPARγ and TLR4-mediated pathways

Macrophage inflammation and foam cell formation are critical events during the initiation and development of atherosclerosis (AS). C1q/tumor necrosis factor-related protein-3 (CTRP3) is a novel adipokine with anti-inflammatory and cardioprotection properties; however, little is known regarding the influence of CTRP3 on AS. As macrophages play a key role in AS, this study investigated the effects of CTRP3 on macrophage lipid metabolism, inflammatory reactions, and phenotype transition, as well as underlying mechanisms, to reveal the relationship between CTRP3 and AS. CTRP3 reduced the number of lipid droplets, lowered cholesteryl ester (CE), total cholesterol (TC), and free cholesterol (FC) levels, reduced the CE/TC ratio, and dose-dependently inhibited TNFα, IL-6, MCP-1, MMP-9 and IL-1β release in lipopolysaccharide (LPS)-stimulated THP-1 macrophages and mouse peritoneal macrophages. Pretreatment with CTRP3 effectively increased macrophage transformation to M2 macrophages rather than M1 macrophages. Western blotting showed that the specific NF-κB pathway inhibitor ammonium pyrrolidine dithiocarbamate (PDTC) or siRNA targeting PPARγ/LXRα markedly strengthened or abolished the above-mentioned effects of CTRP3, respectively. These results show that CTRP3 inhibits TLR4-NF-κB pro-inflammatory pathways but activates the PPARγ-LXRα-ABCA1/ABCG1 cholesterol efflux pathway. Taken together, CTRP3 participates in anti-lipid accumulation, anti-inflammation and macrophage phenotype conversion via the TLR4-NF-κB and PPARγ-LXRα-ABCA1/ABCG1 pathways and, thus, may have anti-atherosclerotic properties.
Women's Erotic Rape Fantasies: An Evaluation of Theory and Research

This article is the first systematic review of the research literature on women's rape fantasies. Current research indicates that between 31% and 57% of women have fantasies in which they are forced into sex against their will, and for 9% to 17% of women these are a frequent or favorite fantasy experience. Erotic rape fantasies are paradoxical: they do not appear to make sense. Why would a person have an erotic and pleasurable fantasy about an event that, in real life, would be abhorrent and traumatic? In this article, the major theories of women's rape fantasies are evaluated both rationally and empirically. These theories explain rape fantasies in terms of masochism, sexual blame avoidance, openness to sexuality, sexual desirability, male rape culture, biological predisposition to surrender, sympathetic physiological activation, and adversary transformation. This article evaluates theory and research, makes provisional judgments as to which theories appear to be most viable, and begins the task of theoretical integration to arrive at a more complete and internally consistent explanation for why many women engage in erotic rape fantasies. Methodological critiques and programs for future research are presented throughout.
Measurement of tissue oxygen extraction ratios from venous blood T2: Increased precision and validation of principle

It has recently been shown that parenchymal oxygen extraction ratios (OERs) can be quantified using the absolute T2 of venous blood draining from this tissue (Oja et al., J Cereb Blood Flow Metab 1999;19:1289–1295). Here, a modified Carr‐Purcell‐Meiboom‐Gill (CPMG) multiecho experiment was used to increase the efficiency and precision of this approach and to test the applicability of the two‐compartment exchange model for spin‐echo BOLD effects in pure venous blood. Relaxation measurements on bovine blood as a function of CPMG interecho spacing, oxygen saturation, and hematocrit provided the baseline relaxation and susceptibility shift parameters necessary to directly relate OER to T2 of venous blood in vivo. Using an interecho spacing of 25 ms, the results on visual activation studies in eight volunteers showed T2(CPMG) values increasing from 128 ± 9 ms to 174 ± 18 ms upon activation, corresponding to local OER values of 0.38 ± 0.04 and 0.18 ± 0.05 during baseline activity and visual stimulation, respectively. These OER values are in good agreement with literature data on venous oxygenation and numbers determined previously using a single‐echo approach, while the measured T2s are about 20–40 ms longer. Magn Reson Med 46:282–291, 2001. © 2001 Wiley‐Liss, Inc.
Efficient calculation of the lightning generated electric field above ground

When studying electromagnetic field problems like lightning phenomena, the efficiency of the adopted model relies on the accurate and rapid calculation of Sommerfeld type Integrals (SI). In the present work we propose an efficient method for calculating them, based on their numerical evaluation along a deformed path of integration. The method is combined with an interpolation technique in order to reduce the number of frequencies required in the Fourier synthesis of the time domain electric field. The result is a fast and straightforward tool for the calculation of aboveground lightning field, without the use of specially developed numerical algorithms or analytical approximations. The proposed approach is also validated through comparison with results obtained with a standard computational methodology.
Self-assembled colloidal complexes of polyphenol-gelatin and their stabilizing effects on emulsions.

This research studies the in-depth characteristics including the binding interactions and morphological structure of tannic acid (TA)/grape seed proanthocyanidins (GSP) and gelatin (GLT) colloidal complexes, and evaluated the stability and lipid oxidation of emulsions formed by the colloidal complexes. Polyphenol and GLT (1.2 wt%) self-assembled complexes were fabricated by varying the mass ratio (1 : 16, 1 : 8 and 1 : 4) and pH in the range of 3-7. TA and GSP can form stable colloidal complexes with GLT at the nanoscale at pH 6, as shown by the particle size results, and the complexes exhibited a spherical morphology as seen by transmission electron microscopy. Hydrogen bonding was the main binding force for the interaction between polyphenols and GLT. The antioxidant activity of GLT was greatly improved after complexing with polyphenols. The oil/water emulsion formed by the complexes had a smaller droplet size and higher lipid oxidation stability during storage. This was largely due to the physical barrier formed by polyphenol-GLT colloidal complexes at the oil-water interface, which can prevent the pro-oxidant from penetrating into oil. These results clarified the structural, morphological and antioxidant properties of polyphenol-gelatin non-covalent complexes, which is of great value for their application in food solutions as well as in emulsion systems.
A Precision Mismatch Measurement Technique for Integrated Capacitor Array Using a Switched Capacitor Amplifier

This paper presents a precision mismatch measurement method to characterize an integrated capacitor array. Conventional mismatch measurement methods using floating gate capacitance measurement (FGCM) have measurement error due to the large input-referred noise and the small input signal range of the source follower. In order to improve the measurement accuracy, we propose a new measurement method using a parasitic-insensitive switched capacitor amplifier and the correlated double sampling (CDS) technique. The CDS technique eliminates the measurement error from parasitic capacitances, switching errors, and the offset voltage of the amplifier. In order to verify the proposed method, a test chip was fabricated using a 0.18-μm CMOS process. The chip consists of a 4 × 16 metal-insulator- metal capacitor array and a measurement circuit. The measured standard deviation of the capacitance mismatch, σ(ΔCn/<;C>), ranges from 0.0067% to 0.0130%, and the measured standard deviation of the short-term repeatability, σ(Δ(ΔCn/<;C>)), is 0.0025%. These results show that the measurement accuracy of the proposed method is improved by ten times over that of the FGCM method.
Nanoscale : Mineral Weathering Boundary

This chapter presents the first overview of the connection between nanoscale weathering and geomorphology, where three overarching themes recur. First, nanoscale processes are on one side of a fundamental threshold between the coarser microscale (micrometers and up) and the finer nanoscale with its dramatically different molecular dynamics. Second, nanoscale processes do impact a variety of prior geomorphic research, including threads related to ongoing instability in mineral weathering, silt production, rock coating behavior, geochemical pollution, thermal weathering from wildfires, and biotic weathering as an explanation for deviations from Goldich’s weathering series. Third, it is possible to link the nanoscale to more classic geomorphic concerns through scaling up quantitatively by digital image processing of microscope imagery and conceptually through connections to weathering forms such as rock splintering. Dorn, R.I. , Gordon, S.J., Krinsley, D. , Langworthy, K. , 2013. Nanoscale: mineral weathering boundary. In: Shroder, J. (Editor in Chief), Pope, G.A. (Ed.), Treatise on Geomorphology. Academic Press, San Diego, CA, vol. 4, Weathering and Soils Geomorphology, pp. 44–69. Treatise on Geomorphology, Volume 4 http://dx.doi. org/10.1016/B978-0-12-374739-6.00065-8 44 4.4.
Persistence of Bactericidal Activity at 4 Years After 2 Primary Doses of a Recombinant, 4-Component, Meningococcal Serogroup B Vaccine (4CMenB) and Response to a Booster Dose in Adolescents and Young Adults

Abstract Background This phase 3b, open label, controlled, multi-center, extension study (NCT02446743) assessed the persistence of bactericidal activity at 4 years post-primary vaccination with a recombinant, 4-component, meningococcal serogroup B vaccine (4CMenB) in adolescents who participated in the parent study NCT01423084 and their response to a booster dose, compared with that in vaccine-naïve healthy controls. Methods Adolescents and young adults previously primed with 4CMenB (2 doses; following a 0,1-month schedule) in study NCT01423084 (group 3B) and vaccine-naïve 15–22 year olds (group B0_1) were enrolled. Group 3B received a booster dose of 4CMenB at 4 years post-primary vaccination; group B0_1 received 2 catch-up doses of 4CMenB (following a 0,1-month schedule). Antibody persistence (primary objective) was evaluated at 4 years post-primary vaccination (in group 3B) vs. baseline (in group B0_1) using human serum bactericidal assay (hSBA), in terms of geometric mean titer (GMT) and percentage (%) of individuals with hSBA titer at least 4. Immune responses at 1 month after booster dose (in group 3B) vs. those at 1 month after first dose (in group B0_1) were also assessed. Results In group 3B, antibody levels declined from 1 month to 4 years post-primary vaccination against all antigens except NHBA, but were higher than in group B0_1 at baseline (Table), with a GMT ratio ≥1.3 and a difference in % of individuals with hSBA titer at least 4 of ≥9%. After one dose of 4CMenB (booster in 3B or first dose in B0_1), GMTs increased (≥4.6-fold in group 3B; ≥2.3-fold in group B0_1), and ≥94% of participants in group 3B and ≥41% of participants in group B0_1 had hSBA titer at least 4 (Table). Conclusion Antibody levels in adolescents and young adults primed with 4CMenB waned over time but were higher at 4 years post-primary vaccination than for vaccine-naïve individuals at baseline. A booster dose of 4CMenB in vaccine-primed individuals elicited higher immune responses than one dose of 4CMenB in vaccine-naïve individuals. The research was supported by GlaxoSmithKline Biologicals SA. Disclosures T. Nolan, GSK group of companies: Research Contractor and Scientific Advisor, Research grant. Pfizer: Research Contractor, Research grant. H. Garfield, Novartis/GSK group of companies: Investigator, Research support. A. Gupta, Novartis/GSK group of companies: Investigator, payment for research-related activities; M. Ferguson, GSK group of companies: Investigator, I receive salary from CRG. CRG has contracts with GSK. H. Marshall, GSK group of companies: Grant Investigator and Investigator, Research grant. Pfizer: Grant Investigator and Investigator, Research grant; sanofi pasteur: Grant Investigator, Research grant. Novavax: Investigator, Research grant. D. D’Agostino, GSK group of companies: Consultant, Consulting fee. D. Toneatto, GSK group of companies: Employee, Salary.
Texture and grain morphology dependencies of saturation magnetostriction in rolled polycrystalline Fe83Ga17

Textured polycrystalline Fe-Ga alloys exhibit magnetostrictive strains of 100 ppm or greater and may function as a mechanically robust actuator/sensing material. Current efforts seek to combine the 300+ ppm magnetostrictive strain performance of [100] oriented single crystals with the mechanical properties of polycrystalline forms. One approach to combining these properties is to control the crystallographic texture through deformation processing such as rolling. To determine the relationship between saturation magnetostriction, degree of texturing, and grain morphology we compare the results of three-dimensional finite element simulations with the analytical solution for a random polycrystal and the experimental responses of rolled polycrystalline Fe83Ga17. Textured specimens were produced through rolling reductions up to 99% of an as-cast ingot and a subsequent 1100 or 590 °C anneal. The high temperature anneal produced a recrystallized grain structure having a wide variation in crystal orientation as d.
Increased spontaneous apoptosis in T lymphocytes in DiGeorge anomaly

The aim of this study was to determine whether increased apoptosis in peripheral blood lymphocytes plays a role in T cell deficiency associated with DiGeorge anomaly. T cell subsets from a patient with DiGeorge anomaly were examined for the expression of Fas, FasL, Bcl‐2 and Bcl‐XL at the protein level with monoclonal antibodies, using dual‐colour flow cytometry, and at the mRNA level in mononuclear cells by quantitative reverse transcriptase‐polymerase chain reaction. In vitro spontaneous apoptosis was examined by propidium iodide staining and DNA fragmentation, using flow cytometry and gel electrophoresis, respectively. Fas and FasL expression, both at the level of protein and of mRNA, was increased, whereas Bcl‐2 expression was decreased both at the level of protein and of mRNA. However, no difference in Bcl‐XL expression was observed between the patient and an age‐matched control. A significant proportion of both CD4+ and CD8+ T cells from the patients underwent spontaneous apoptosis, whereas almost no spontaneous apoptosis was observed in the age‐matched control. These data suggest that spontaneous apoptosis in T lymphocytes, at least in part, may be responsible for T cell deficiency in DiGeorge anomaly.