Miracle-dz/UniFAR-FTUs huggingface dataset:
Kidney function and metabolic profile of chronic kidney disease and hemodialysis patients during Ramadan fasting.

INTRODUCTION This study aimed to investigate effects of fasting during the Ramadan month among chronic kidney disease (CKD) and hemodialysis patients. MATERIALS AND METHODS A prospective study was carried out on patients seen between August and November 2010 at two hospitals of King Saud University. Volunteers from among patients with CKD and hemodialysis patients were evaluated for kidney function and complications before, during, and after 14-hour daily Ramadan fasting for 30 days. A modified schedule for medication and dialysis regimen was provided to the participants. RESULTS Thirty-nine CKD patients (41.0% in stage 3 and 43.6% in stage 4) were included. There were no differences in the laboratory and clinical variables before, during, and after the fasting month. Thirty-two hemodialysis patients with a mean duration of dialysis of 4.4 +/- 3.7 years were also included in the study. There was a significant increase in erythrocyte count, serum creatinine, blood urea, serum phosphorus, serum albumin, and serum uric acid levels during the fasting period. Hyperkalemia developed in 25.0% and 15.6% of the hemodialsysis patients during and after the fasting period and hyponatremia in 15.6% and 28.0%, respectively. Forty-six percent of the patients developed hypertension and 36.7% fluid overload. No adverse events requiring hospital admission were observed. CONCLUSIONS Fourteen-hour fasting for one month was tolerated by CKD and hemodialysis patients, although there were considerable changes among hemodialysis patients in some of the blood chemistry variables. No serious adverse events occurred.
Brief report: Exploring the benefits of a peer‐tutored physical education programme among high school students with intellectual disability

BACKGROUND The purpose of this study was to explore possible benefits of a peer-tutored physical education programme (PTPE) in comparison with school physical education (SPE) in high school students with intellectual disability. METHOD Nineteen students with intellectual disabilities (15 boys, mean age 17.4 ± 1.7 years) were monitored during three PTPE and three SPE classes. A factorial RM-ANOVA was used to test differences on objective measured physical activity (PA), enjoyment and exertion during the two conditions, considering participants' weight condition as independent factor. RESULTS During PTPE, participants reported higher light intensity PA, enjoyment and exertion than during SPE. Participants with overweight showed less inactive time and higher light intensity PA during PTPE than during SPE. CONCLUSIONS The peer-tutored programme was beneficial for adolescents with intellectual disability, particularly for those in overweight condition. The higher enjoyment found during PTPE may encourage exercise participation of students with intellectual disability.
Understanding moral habitability: A framework to enhance the quality of the clinical environment as a workplace

Abstract There is compelling evidence in the nursing literature that the workplace is experienced as morally uninhabitable for many nurses and yet the concept of moral habitability remains underdeveloped. An integrative review on moral habitability in nursing was undertaken. The findings reveal that the primary concepts by which nurses write and research aspects of moral habitability are moral climate, moral agency, moral sensitivity and moral distress. It is revealed that nurses in their clinical work experience adversity and moral distress through relational challenges and contextual difficulties that can challenge habitability and inhibit nurses’ capacity to provide morally sensitive patient care. The primary concepts identified provide a framework for further development of the concept of moral habitability within nursing practice. The related data within the integrative review also highlights the need for further research into enhancing and sustaining morally habitable workplaces for nurses.
Does Value Creation Drives Growth Illusion? An Evidence from Indonesia Stock Exchange

The main aim of this study is to explore the illusion effect on the growth market of firm value, and to examine the value creation of manufacturing companies listed in the Indonesia Stock Exchange (IDX). The study used pooled data of the manufacturing companies listed in the Indonesia Stock Exchange (IDX), and estimated the overvaluation using the model developed by Rhodes-Kropf, Robinson, and Viswanathan (2005). The real earnings management, based on overproduction and auditing, results on an increase in the valuation. However, the value of creating actions of the firms in the form of accrual management and real earnings management based on discretionary expense are less likely to significantly contribute to shape the overvaluation.The findings are helpful for regulators to improve supervision to real earnings management based on overproduction and the use of the Big Four auditors to prevent any potential value creation that leads to misvaluation in the market, as well as for professionals, investors and analysts to evaluate the quality of accounting numbers, select a portfolio of stocks, and make lending decisions.Unlike any previous studies highlighting the consequences of overvaluation and focusing on predicting the occurrence of overvaluation as a result of earnings management practices, this study mainly focuses on the earnings management as the cause of the overvaluation in the form of variables of accrual management and real earnings management based on discretionary expenses and overproduction.
Consumers’ Perspective on Circular Economy Strategy for Reducing Food Waste

The current linear system of production and consumption is unsustainable. In the food sector, despite the fact that valuable natural resources are intensively used to produce and distribute food products, little is done to upcycle residues generated along the supply chain. Circular economy strategies are crucial for restructuring the take-make-dispose model through the active participation of all actors of supply chains. However, little is known about consumers’ willingness to participate in circular economy. A structured questionnaire was submitted to a representative sample of Italian households to assess the willingness of consumers to be actively involved in closed loops aiming at reducing food waste. Consumers are involved by returning their organic food waste to retailers in exchange for discounts on the purchase of animal products. The organic food waste returned enters in the production process of animal products. A choice experiment was designed to analyse alternative programs. Two scenarios were presented: one with a traditional technology (composting), and a second one with a radically innovative technology (insects as feed). Preferences and trade-offs, in monetary terms, among attributes were computed. Results depict a comprehensive portrait of the potential participation of consumers to closed loops inspired by the principles of circular economy.
Total Factor Productivity and Efficiency Analysis on Islamic Banks in Indonesia

The aims of this study are to measure productivity and efficiency, to analyze factors which affect the level of efficiency and to analyze the correlation between productivity and efficiency of Islamic Banking in Indonesia. The objects of this study are 11 (eleven) Islamic Banks (BUS) in Indonesia which are analyzed from the second quarter of 2010 to the third quarter of 2015. The result shows only six of the eleven banks that have a good productivity level, otherwise, for efficiency, there are only three banks that efficient enough. Furthermore, the relationship between productivity and efficiency levels that are categorized into 4 (four) quadrants. In quadrant I, three banks have high productivity and efficiency namely Syariah Mandiri, Panin Syariah and Victoria Syariah; quadrant IV two banks in a low level of productivity and efficiency namely Mega Syariah and Bukopin Syariah. While the quadrant II namely BCA Syariah, BRI Syariah, and Muamalat and quadrant III namely BJB Syariah, BNI Syariah, and Maybank Syariah required further research to determine the factors that affect the productivity and efficiency relationships that occur. JEL Classification : D24; D57; D61 DOI : https://doi.org/10.26905/jkdp.v22i1. 1333
Doing What we Know we Should: Engaged scholarship and community development

In Australia, engaged scholarship oriented towards community development objectives has yet to be recognised in funding regimes as being inherently beneficial in terms of scholarly excellence and university rankings. While the civic role of universities is acknowledged by individual universities, higher education management and at the Federal policy level, they are most often framed as funding problems related to ‘community service’ rather than as research opportunities which can raise the university’s profile by providing the basis for excellent research outputs and community enrichment. Community engagement has become a familiar term in the Australian higher education lexicon in recent years but there is still little institutional infrastructure that directly embodies the principles and sentiment of community engagement evident in current Australian universities. In this paper, the inaugural Director and Research Manager of the University of Queensland’s Community Service and Research Centre reflect on their five years leading a Centre that was/has been privileged to enjoy significant institutional support and the lessons learnt in forging into unknown territories. The reflections focus on the Centre’s seminal project, the Goodna Service Integration Project.
Impact of Audit Quality on Earnings Management: Case of Lebanon

The lack of transparency in financial statements in Lebanon is a chronic problem that induced less confidence of the shareholders. This paper addresses the latter in order to have a better understanding about how audit quality affects the level of earnings management in companies operating in Lebanon. The findings will help inter alia remedy issues such as fraud, fiscal evasion, and enhance the legitimacy of the financial statements. The audit quality is measured by the audit firm size, and the level of earnings management is measured by the discretionary accruals reported in the financial statements. Using an empirical study with a sample of 50 companies operating in the Lebanese market, the research findings suggest that the level of earnings management of audited companies is significantly lower compared to non-audited companies. There no significant difference between mandatory and voluntary audits in mitigating earnings management, Companies audited by large auditors proved to have a significantly lower level of earnings management than companies audited by small auditors. Finally, the effect of Big 4, the four largest international audit firms in the world, in mitigating earnings management does not significantly differ from other auditors, yet it was proved that the odds of having a high level of earnings management is lower when companies are audited by Big 4 audit firms.
Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

We previously demonstrated a correlation between the presence of syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) variants showing tropism for cell line H9 and the occurrence of rapid CD4 cell decline and progression to AIDS. In contrast, in stable asymptomatic individuals, we detected only isolates with low replication rates that were non-syncytium-inducing (NSI) and nontropic for the H9 cell line. Here, we investigated the monocytotropism of established HIV-1 isolates with a panel of isolates and with biological HIV-1 clones with distinct phenotypes. Moreover, the prevalence and biological phenotypes of monocytotropic HIV-1 variants in the course of HIV-1 infection were analyzed in comparative primary isolation studies on peripheral blood lymphocytes (PBL) and monocyte-derived macrophages (MDM). In cell-free infection studies with MDM from eight blood donors, 13 of 17 NSI isolates but only 4 of 14 SI isolates were able to infect MDM. NSI isolates also infected significantly more different donors than SI variants (median, 3 of 8 versus 0 of 8). This enhanced monocytotropism of NSI isolates was confirmed in experiments with biological HIV-1 clones with distinct phenotypes recovered from the same donor. To investigate the prevalence and biological phenotypes of monocytotropic variants in different stages of HIV-1 infection, sequential isolates from peripheral blood mononuclear cell samples from nine asymptomatic individuals, five of whom progressed to AIDS and seven of whom had a known time of seroconversion, were recovered by cocultivation with both PBL and MDM. Monocytotropic variants were obtained from 37 of 42 time points. All monocytotropic variants were NSI in PBL culture and non-T-cell-line tropic, even when SI, T-cell-line-tropic HIV-1 variants could be recovered from the same patient sample by cocultivation with PBL. We conclude that monocytotropic HIV-1 variants mostly have an NSI phenotype in PBL and, in contrast to SI variants, are present at all stages of HIV-1 infection. These results suggest an important role for monocytotropic variants in the persistence of HIV-1 infection.
Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis

ObjectiveWe investigated whether musculoskeletal ultrasonography (MSKUS) assists the diagnostic performance of the 2010 rheumatoid arthritis (RA) classification criteria.MethodsSixty-nine early arthritis patients were consecutively enrolled. None of the patients had been treated. In MSKUS of bilateral wrist and finger joints from 22 sites, the findings obtained by gray-scale and power Doppler (PD) assessment were graded on a semiquantitative scale from 0 to 3. Plain magnetic resonance imaging (MRI) of both wrist and finger joints was also examined. Diagnosis of RA was defined by the initiation of disease-modifying antirheumatic drugs within the first 3 months. The diagnostic performance of the patients was evaluated at entry using 2010 RA classification criteria in conjunction with MSKUS.ResultsThe indispensable MSKUS finding for differentiating RA was the presence of a PD grade 2 or 3 that was superior to 2010 RA classification criteria or MRI-proven bone edema. We propose that the decision tree algorithm of 2010 RA classification criteria with PD grade 2 or 3 reveals the best discriminative ability.ConclusionMSKUS, especially with a strong PD signal, is very useful to assist the diagnostic performance of the 2010 RA classification criteria in the early recognition of RA.
OCCUPATIONAL EXHAUSTION AMONG PRISON STAFF: MULTIVARIATE ANALYSIS OF CORRELATES ASSOCIATED WITH EMOTIONAL EXHAUSTION

This article investigates the multivariate relationship between personal characteristics of prison staff, their work rank within the organizational hierarchy, working conditions, constraints of personal accomplishment, stressresponse states, and the emotional exhaustion. Specifically, this study attempts to determine the amount of variation that can be explained in emotional exhaustion, the main dependant variable, by using the above variables. The analysis are based on the data that were collected in 2010 from 480 prison staff members in three prisons in the State of Indiana, U.S.A. Hierarchical multiple regression analysis revealed that the best predictors of emotional exhaustion among prison staff are stress-response states and constraints of personal accomplishment, both of which are positively associated with emotional exhaustion. A thirteen-variable regression model used in this study explains 51% of the variation in the emotional exhaustion.
The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance.

The Slit gene encodes a secreted molecule essential for neural development in Drosophila embryos. Here we report the identification of three Slit homologues in the mouse. We demonstrate that the mouse SLIT1 protein can bind ROBO1, a transmembrane receptor implicated in axon guidance. Both whole-mount and section in situ hybridization studies reveal unique and complementary patterns of expression of the three mouse Slit genes and of Robo1, both within the central nervous system and in other developing tissues. The complementary expression patterns of Slit and Robo1 and their in vitro interaction suggest a ligand-receptor relationship. The expression of all three Slit genes in the floor plate suggests that they are likely to share the same functional properties with their Drosophila homologue in midline neural development and axon guidance. The complementary expression of Slit and Robo1 in different subdivisions of the somites suggests their possible function in axon pathfinding and neural crest cell migration. The unique expression pattern in limb and other organs indicates additional potential functions of the Slit gene family.
Role of atrial septostomy in the treatment of children with pulmonary arterial hypertension

Objectives: To assess in retrospect the safety and effectiveness of atrial septostomy in children with severe pulmonary arterial hypertension without an intracardiac communication. Methods: 20 patients were reviewed retrospectively, 19 with idiopathic pulmonary arterial hypertension. The mean age at septostomy was 8.4 years (range 3 months to 17 years). Graded balloon septostomy alone was carried out in eight patients, a blade septostomy was done in two, a blade septostomy plus graded balloon septostomy was done in three, and a fenestrated device was inserted in seven. Results: There were no fatalities. Four children suffered complications during the procedure. None had further syncope and all improved symptomatically with a significant (p < 0.01) decrease in World Health Organization functional class (mean shift −0.6) and a significant improvement in the semiquantitative echocardiographic assessment of right ventricular function (p < 0.03). The mean oxygen saturation decreased by 7.8 percentage points. The atrial communication closed in two children, necessitating a repeat procedure. After a mean follow up of 2.1 years (range one month to 6.7 years), 18 of 20 children are still alive. Conclusion: Atrial septostomy improved symptoms and quality of life in a group of children deteriorating with severe pulmonary arterial hypertension. This procedure is to be recommended for severely symptomatic children, before they become critically ill. Fenestrated devices may help ensure indefinite patency of the atrial communication.
A randomized double-blind comparison of epidural versus intravenous fentanyl infusion for analgesia after thoracotomy.

This study compared epidural and intravenous fentanyl infusions for pain relief for the first 20 h after thoracotomy, in order to examine whether an thoracic epidural fentanyl infusion offers clinical advantage over an intravenous infusion. Forty patients were assigned randomly to receive either fentanyl epidurally and saline intravenously or fentanyl intravenously and saline epidurally in a double-blind fashion. For each patient the fentanyl infusion was titrated to a rate required for pain relief (pain score less than 3, maximum 10). Patients reported similar median pain scores, but in the epidural group the required mean fentanyl infusion rate was less (0.95 +/- 0.23 vs. 1.67 +/- 0.46 micrograms.kg-1.h-1, P = 0.0001) and plasma fentanyl concentrations were less at 4 and 18 h (4 h: 0.81 +/- 0.27 vs. 1.38 +/- 0.36 ng.ml-1, P = 0.0001; 18 h: 0.94 +/- 0.32 vs. 1.54 +/- 0.65 ng.ml-1, P = 0.0007) than those in the intravenous group. Respiratory function was better preserved and the incidence of nausea and sedation was less in the epidural group than in the intravenous group. In conclusion there appears to be a clinical advantage to the epidural infusion over the intravenous infusion of fentanyl for analgesia after thoracotomy.
BRCA1 16 years later: DNA damage‐induced BRCA1 shuttling

The tumor suppressor, breast cancer susceptibility gene 1 (BRCA1), plays an integral role in the maintenance of genome stability and, in particular, the cellular response to DNA damage. Here, the emerging role of BRCA1 in nonhomologous end‐joining‐mediated DNA repair following DNA damage will be reviewed, as well as the activation of apoptotic pathways. The control of these functions via DNA damage‐induced BRCA1 shuttling will also be discussed, in particular BRCA1 shuttling induced by erlotinib and irradiation. Finally, the potential targeting of BRCA1 shuttling as a novel strategy to sensitize cells to DNA damage will be entertained.
The Effect of Learning Organization Environment and Innovative Work Behavior Under the Moderation Role of Employee Engagement in Public Sector Organization

The main objective of the study is to explore the impact of learning organization environment on innovative work behavior. The study results show that learning organization environment explained a significant relation with innovative work behavior also with the mediator variable that is employee engagement. Convenience sampling is used as the sampling strategy. This survey is based on questionnaire and data is collected from 140 managers of Public sector organizations located in Faisalabad. To analyses the data, SPSS version 23.0 is used. To check the relationship between the variables correlation analysis is used and to checks the effect between variables linear regression analysis is used. Thus, all the hypotheses showed significant results. Keywords: Learning Organization environment, innovative work behavior, employee engagement
ANALISIS PENGARUH CORPORATE GOVERNANCE TERHADAP KEMUNGKINAN PEMBERIAN OPINI AUDIT GOING CONCERN OLEH AUDITOR INDEPENDEN (STUDI EMPIRIS PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI TAHUN 2009-2011)

The aim of this study is to examine the effect of the role of corporate governance to the possibility of issuance of going concern audit opinion by an independent auditor. The independent variables are used in this study is the proportion of independent directors, managerial ownership, and institutional ownership. This study is a replication of the study by Alexander et al., (2011) and used 84 manufacturing companies which listed on the Stock Exchange in the period 2009-2011 as the sample. Samples were selected by purposive sampling method and finally obtained 38 companies manufacturing a going concern audit opinion and 46 manufacturing companies with non-going concern audit opinion. Data were analyzed using logistic regression analysis model. The results show that the proportion of independent directors and institutional ownership has no effect on the issuance of going concern audit opinion by an independent auditor, while managerial ownership affect the administration going concern audit opinion by an independent auditor.