Miracle-dz/UniFAR-FTUs huggingface dataset:
Interactions between non-native armored suckermouth catfish (Loricariidae: Pterygoplichthys) and native Florida manatee (Trichechus manatus latirostris) in artesian springs

Non-native suckermouth armored catfishes (Loricariidae) of the genus Pterygoplichthys are now common throughout much of peninsular Florida. In this paper, we present preliminary observations on interactions between a Pterygoplichthys species, tentatively identified as P. disjunctivus (Weber, 1991), and endangered native Florida manatees, Trichechus manatus latirostris (Harlan, 1824), in artesian spring systems in Florida's St. Johns River drainage. The introduced catfish have become abundant in spring habitats, sites used by manatees as winter thermal refuges. In the spring runs, Pterygoplichthys regularly attaches to manatees and grazes the epibiota on their skin. On occasion, dozens of Pterygoplichthys congregate on individual manatees. Manatee responses varied widely; some did not react visibly to attached catfish whereas others appeared agitated and attempted to dislodge the fish. The costs and/or benefits of this interaction to manatees remain unclear.
Spectral stochastic estimation of high-Reynolds-number wall-bounded turbulence for a refined inner-outer interaction model

For wall-bounded flows, the model of Marusic et al. [Science 329, 193 (2010)] allows one to predict the statistics of the streamwise fluctuating velocity in the inner region, from a measured input signal in the logarithmic region. Normally, a user-defined large-scale portion of the input forms the large-scale content in the prediction by scaling its amplitude, as well as temporally shifting the signal to account for the physical inclination of these scales. Incoherent smaller scales are then fused to the prediction via universally expressed fluctuations that are subject to an amplitude modulation. Here we present a refined version of the model using spectral linear stochastic estimation, which eliminates a user-defined scale separation of the input. Now, an empirically derived transfer kernel comprises an implicit filtering via a scale-dependent gain and phase; this kernel captures the coherent portion in the prediction. An additional refinement of the model embodies a relative shift between the stochastically estimated scales in the prediction and the modulation envelope of the universal small scales. Predictions over a three-decade span of Reynolds numbers, Re-tau similar to O(10(3)) to O(10(6)), highlight promising applications of the refined model to high-Reynolds-number flows, in which coherent scales become the primary contributor to the fluctuating energy.
Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib

Tumors with anaplastic lymphoma kinase (ALK) fusion rearrangements, including non-small-cell lung cancer and anaplastic large cell lymphoma, are highly sensitive to ALK tyrosine kinase inhibitors (TKIs), underscoring the notion that such cancers are addicted to ALK activity. Although mutations in ALK are heavily implicated in childhood neuroblastoma, response to the ALK TKI crizotinib has been disappointing. Embryonal tumors in patients with DNA repair defects such as Fanconi anemia (FA) often have a poor prognosis, because of lack of therapeutic options. Here we report a child with underlying FA and ALK mutant high-risk neuroblastoma responding strongly to precision therapy with the ALK TKI ceritinib. Conventional chemotherapy treatment caused severe, life-threatening toxicity. Genomic analysis of the initial biopsy identified germline FANCA mutations as well as a novel ALK-I1171T variant. ALK-I1171T generates a potent gain-of-function mutant, as measured in PC12 cell neurite outgrowth and NIH3T3 transformation. Pharmacological inhibition profiling of ALK-I1171T in response to various ALK TKIs identified an 11-fold improved inhibition of ALK-I1171T with ceritinib when compared with crizotinib. Immunoaffinity-coupled LC-MS/MS phosphoproteomics analysis indicated a decrease in ALK signaling in response to ceritinib. Ceritinib was therefore selected for treatment in this child. Monotherapy with ceritinib was well tolerated and resulted in normalized catecholamine markers and tumor shrinkage. After 7.5 mo treatment, the residual primary tumor shrunk, was surgically removed, and exhibited hallmarks of differentiation together with reduced Ki67 levels. Clinical follow-up after 21 mo treatment revealed complete clinical remission including all metastatic sites. Therefore, ceritinib presents a viable therapeutic option for ALK-positive neuroblastoma.
Leadership and management competencies of head nurses and directors of nursing in Finnish social and health care

This paper describes the leadership and management competencies of head nurses and directors of nursing in social and health care. In the nursing profession, studies have tended to describe the role of the nurse manager, or to provide lists of competencies, talents and traits which can be found in successful managers. However, nursing managers’ leadership and management competencies lack any depth of research knowledge. Data were gathered by electronic questionnaire. Respondents (n = 1025) were head nurses and directors of nursing. The data were statistically analysed. Both groups evaluated their leadership and management competencies to be quite good and their general competence to be better than their special competence. Overall, directors of nursing rated their general competence and special competence better than head nurses. However, the head nurses had a stronger expertise in general competence areas, professional competence and credibility, and also in the special competence areas of substance knowledge than the directors of nursing. While the overall leadership and management competencies were good for both groups, each has identified areas which can be further developed.
Predicting Sibling Relationship Quality from Family Conflict: A LongitudinalStudy from Early Adolescence to Young Adulthood

Socialization experiences in the family have profound and lasting effects on development. The present study investigated whether exposure to family conflict in early adolescence influences relationship quality with siblings during young adulthood. Using a longitudinal design, observations of family conflict were used to predict self- and other-reported sibling relationship quality a decade later in an at-risk sample of 98 male and female older siblings of target boys in the Oregon Youth Study. Results indicated that familial conflict during early adolescence reliably predicted quality of sibling relationships during emerging adulthood. These findings are discussed with respect to social learning theory, previous research, and treatment implications.
Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis.

OBJECTIVE The aim of this systematic review was to compare outcomes between surgical and non-surgical treatment of actinic cheilitis (AC). MATERIALS AND METHODS A systematic review and meta-analysis based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline were performed. A search of PubMed/MEDLINE, Web of Science, and Cochrane Library databases was conducted. Articles were selected based on the inclusion criteria: randomized clinical trials, prospective/retrospective studies, and case series with at least 10 patients, with a minimum follow-up period of 6 months. A weighted remission rate (RER) and recurrence rate (RR) with a 95% confidence interval was performed. Data analysis was performed using a comprehensive meta-analysis software. RESULTS A total of 283 ACs in 10 studies were included. About 2.5% surgically treated cases underwent malignant transformation. The weighted remission rate was higher for surgical (92.8%) compared to non-surgical treatment (65.9%). The recurrence rate was lower for surgical (8.4%) compared to non-surgical treatment (19.2%). CONCLUSION In this systematic review, the surgical treatment was more favorable than non-surgical for AC. Meanwhile, further studies are needed that should maximize methodological standardization and have greater rigor of the data collection process.
Comparing HIV risk-related behaviors between 2 RDS national samples of MSM in Brazil, 2009 and 2016

Introduction: Periodic monitoring of sociobehavior characteristics at a national level is an essential component of understanding the dynamics the human immunodeficiency virus (HIV) epidemic worldwide, including Brazil. Methods: This paper compares descriptive sociobehavior characteristics in 2 national cross-sectional HIV biological behavioral surveillance surveys (BBSS) conducted in 2009 and 2016 among men who have sex with men (MSM) in Brazil. Respondent driven sampling (RDS) was used for recruitment in both years. Overall proportions were weighted according to Gile's estimator using RDS Analyst Software and 95% confidence intervals were calculated for comparisons between the 2 periods. Further comparisons were stratified by age groups (<25 and 25+ years old). Results: Overall, 3749 and 4176 MSM were recruited in 2009 and 2016, respectively. In 2016, participants were younger than 25 years old (58.3%), with 12 or more years of education (70.4%), with higher socioeconomic status (40.7%), and had a higher proportion of whites (31.8%), as compared to 2009. Also, participants in 2016 reported less alcohol use and binge drinking, but used illicit drugs more frequently. There was an increase among MSM who self-reported their HIV risk as low and had low HIV knowledge while the proportion of those who were never tested for HIV dropped from 49.8% in 2009 to 33.8% in 2016. Although more than three-quarters received free condoms in both years, STD counseling remained low (32% and 38% for 2009 and 2016, respectively). Sexual risk behavior remained at high levels, especially unprotected anal receptive sex and sex with multiple partners. Younger MSM (<25 years old) showed riskier sexual practices than those 25+ years old, when comparing 2016 to 2009. Conclusions: Our results indicate a worrisome risk behavior trend among Brazilian MSM, especially among younger ones. These results can contribute for a better understanding of the HIV epidemics in Brazil, with timely shift in strategies so improved effectiveness in public health prevention efforts can be achieved.
The association between gender and tooth loss in a small rural population of South Africa

Periodontal disease, which attacks the gums and supporting structures of the tooth, is one of the major causes of tooth loss in adults. Few studies on general well-being have compared the differences in oral health between men and women with studies from Europe and USA reporting that there are more edentulous women than men.Among the many factors contributing to tooth loss are poverty, availability and accessibility to dental and other health care as well as cultural traditions. This study examined a population living in a high fluoride area near Cape Town. This isolated community has until recently been unexposed to the diets and habits of the western world and have inter-married for decades. The results of this study indicated that although women had better oral hygiene habits than men, tooth loss was associated with age rather than gender.
Tensor-Product-Model-Based Control of a Three Degrees-of-Freedom Aeroelastic Model

Active control of aeroelasticity has been in the focus of aerospace and control engineering for several decades. An introduction to this topic can be found in [1]. This paper largely focuses on the three degrees-of-freedom (DoF) Nonlinear Aeroelastic Test Apparatus (NATA) model. The NATA model with unsteady aerodynamics was presented in [2, 3] and several active controllers were developed in [4 14]. LPV control of an improved three DoF aeroelastic model is discussed in [15]. The aim of this paper is to propose a control design strategy to stabilize the improved 3 DoF NATA model presented in [15], as well as to stabilize the NATA model with nonlinear friction. It is assumed that only the free stream velocity and the pitch angle are measurable, thus an output feedback control structure is applied. The control design considers the following performance requirements: asymptotic stability, decay rate and constraint on the control signal, which are formulated in terms of Linear Matrix Inequalities (LMIs). The proposed control design strategy has two main steps. First, the quasi linear parameter varying (qLPV) NATA model is transformed into Tensor Product (TP) type polytopic form via TP model transformation ([16 18]). LMI based control design is applied to the TP type polytopic form in the second step, which yields in stabilising controller and observer via optimising the control performance. Besides resulting in a stabilising control solution to the 3 DoF NATA model, it is shown that
Complex , Timor-Leste : provenance and metamorphic cooling history Ar hornblende ages from the Aileu 39 Ar / 40 Pb and − Detrital zircon

Geochronological data from the Aileu Complex provide new constraints on the development of the Banda Arc–continent collision. Detrital zircons of the Aileu Complex have major U–Pb age modes at 270–440 Ma, 860–1240 Ma and 1460–1870 Ma, most compatible with a sediment source located in SE Asia as part of the now fragmented Sula Spur. 40Ar/39Ar cooling ages of hornblende demonstrate an extended cooling history across the complex, with the eastern parts cooling through hornblende closure temperature by 10 Ma and central parts by 6 Ma, consistent with a variable exhumation history. The onset of cooling by 10 Ma implies that metamorphism was probably coeval with initiation of the Banda Arc. We propose that the Aileu Complex cooling ages record deformation related to fragmentation of the Sula Spur and early development of the Banda Arc, rather than collision between the Australian continent and the Banda Arc. Supplementary material: Detrital zircon U–Pb analytical results, hornblende argon isotope geochronology sample details, hornblende 40Ar/39Ar step heating analytical results and hornblende electron microprobe analytical results are available at www.geolsoc. org.uk/SUP18702. research-articleResearch ArticleXXX10.1144/jgs2012-065K. S. Ely et al.Aileu Complex: Provenance and Cooling 2013 by guest on December 20, 2013 http://jgs.lyellcollection. org/ Downloaded from
Spin-off: Individual, Firm, Industry and Regional Determinants

The extent and importance of spin-offs for industrial dynamics have been analysed in a number of previous studies, yet knowledge is surprisingly scarce about the determinants that trigger such entrepreneurial ventures. In the current analysis we use unique and detailed Swedish data to comprehensively explore how individual, firm, regional, and industry variables influence spin-offs during 1999-2005. In addition to the expected general positive impact of regional size and entrepreneurial culture, we find specific features for knowledge intensive manufacturing and service production on the propensity of employees to spin off a new venture. Moreover, we use an entropy measure to disentangle unrelated and related variety, and find that the former has a significantly negative impact while the latter a significantly positive effect on the propensity of the individual to start a spin-off.
Life situation after stroke : The spouses´perspective

AIM: This paper reports a study to validate and test the reliability of a questionnaire constructed to evaluate the life situation of spouses after their partners have had a stroke.BACKGROUND: Stroke is a disease with great consequences for survivors and their families. Most survivors return home after the hospitalization and rehabilitation due to the stroke event. Relatives, primarily spouses, often feel obligated to care for the survivor at home, providing emotional support or assisting the person in activities of daily living. More specific information is needed about the spouse's life situation after the stroke event in order to develop effective supportive strategies.METHODS: Psychometric testing of the Life Situation Questionnaire was undertaken with 99 spouses of stroke survivors. The 13-item questionnaire consists of four subscales: 'Worries', 'Powerlessness', 'Personal adjustment' and 'Social isolation'. RESULTS: Item analysis showed that each item correlated with its own subscale (r = 0.63-0.78). The instrument had high internal consistency, with Cronbach's alphas of 0.80-0.86 and reasonable high congruent validity when correlated with a Wellbeing instrument, with a correlation of 0.59 (P = 0.001). Exploratory factor analysis confirmed the subscales, accounting for 77% of the variance.CONCLUSION: The Life Situation Questionnaire is a valid and reliable instrument, and could serve as an assessment tool after a stroke event to identify family caregivers who have problems in their life situations and need support from healthcare services.
MOTIVATION AND LEARNING ENGAGEMENT THROUGH PLAYING MATH VIDEO GAMES

Purpose: With video games being a source of leisure and learning, educators and researchers alike are interested in understanding children’s motivation for playing video games as a way to learn. This study explores student motivation and engagement levels in playing two math video games in the game Club Penguin. Method: This is a qualitative case study conducted in a North American elementary school after-school program. It involves two children ages eight and nine playing math games. Data sources in this study include interviews, observations and video recordings of game
Uniform California Earthquake Rupture Forecast, Version 2 (UCERF 2)

The 2007 Working Group on California Earthquake Probabilities (WGCEP, 2007) presents the Uniform California Earthquake Rupture Forecast, Version 2 (UCERF 2). This model comprises a time-independent (Poisson-process) earthquake rate model, developed jointly with the National Seismic Hazard Mapping Program and a time-dependent earthquake-probability model, based on recent earthquake rates and stress-renewal statistics conditioned on the date of last event. The models were developed from updated statewide earthquake catalogs and fault deformation databases using a uniform methodology across all regions and implemented in the modular, extensible Open Seismic Hazard Analysis framework. The rate model satisfies integrating measures of deformation across the plate-boundary zone and is consistent with historical seismicity data. An overprediction of earthquake rates found at intermediate magnitudes (6.5≤ M ≤7.0) in previous models has been reduced to within the 95% confidence bounds of the historical earthquake catalog. A logic tree with 480 branches represents the epistemic uncertainties of the full time-dependent model. The mean UCERF 2 time-dependent probability of one or more M ≥6.7 earthquakes in the California region during the next 30 yr is 99.7%; this probability decreases to 46% for M ≥7.5 and to 4.5% for M ≥8.0. These probabilities do not include the Cascadia subduction zone, largely north of California, for which the estimated 30 yr, M ≥8.0 time-dependent probability is 10%. The M ≥6.7 probabilities on major strike-slip faults are consistent with the WGCEP (2003) study in the San Francisco Bay Area and the WGCEP (1995) study in southern California, except for significantly lower estimates along the San Jacinto and Elsinore faults, owing to provisions for larger multisegment ruptures. Important model limitations are discussed.
Financial Valuation and Risk Management Working Paper No . 512 Convergence in the Semimartingale Topology and Constrained Portfolios

Consider an Rd-valued semimartingale S and a sequence of Rd-valued S-integrable predictable processes Hn valued in some closed convex set K ⊂ Rd , containing the origin. Suppose that the real-valued sequence Hn · S converges to X in the semimartingale topology. We would like to know whether we may write X = H0 ·S for some Rd-valued, S-integrable process H0 valued in K ? This question is of crucial importance when looking at superreplication under constraints. The paper considers a generalization of the above problem to K = K (ω, t) possibly time dependent and random. Christoph Czichowsky Department of Mathematics ETH Zurich Rämistrasse 101 CH-8092 Zurich e-mail: christoph.czichowsky@math.ethz. ch Nicholas Westray Department of Mathematics Humboldt Universität Berlin Unter den Linden 6 10099 Berlin e-mail: westray@math.hu-berlin.de Harry Zheng Department of Mathematics Imperial College London SW7 2AZ e-mail: h.zheng@imperial.ac. uk
De novo lipogenesis represents a therapeutic target in mutant Kras non‐small cell lung cancer

Oncogenic Kras mutations are one of the most common alterations in non‐small cell lung cancer and are associated with poor response to treatment and reduced survival. Driver oncogenes, such as Kras are now appreciated for their ability to promote tumor growth via up‐regulation of anabolic pathways. Therefore, we wanted to identify metabolic vulnerabilities in Kras‐mutant lung cancer. Using the KrasLSL‐G12D lung cancer model, we show that mutant Kras drives a lipogenic gene‐expression program. Stable‐isotope analysis reveals that mutant Kras promotes de novo fatty acid synthesis in vitro and in vivo. The importance of fatty acid synthesis in Kras‐induced tumorigenesis was evident by decreased tumor formation in KrasLSL‐G12D mice after treatment with a fatty acid synthesis inhibitor. Importantly, with gain and loss of function models of mutant Kras, we demonstrate that mutant Kras potentiates the growth inhibitory effects of several fatty acid synthesis inhibitors. These studies highlight the potential to target mutant Kras tumors by taking advantage of the lipogenic phenotype induced by mutant Kras. —Singh, A. , Ruiz, C. , Bhalla, K. , Haley, J. A. , Li, Q. K. , Acquaah‐Mensah, G. , Montal, E. , Sudini, K. R. , Skoulidis, F. , Wistuba, I. I. , Papadimitrakopoulou, V. , Heymach, J. V. , Boros, L. G. , Gabrielson, E. , Carretero, J., Wong, K. ‐K. , Haley, J.D. , Biswal, S. , Girnun, G.D. De novo lipogenesis represents a therapeutic target in mutant Kras non‐small cell lung cancer. FASEB J. 32, 7018–7027 (2018). www.fasebj. org
Salvage Logging Versus the Use of Burnt Wood as a Nurse Object to Promote Post‐Fire Tree Seedling Establishment

Intense debate surrounds the effects of post‐fire salvage logging (SL) versus nonintervention policies on forest regeneration, but scant support is available from experimental studies. We analyze the effect of three post‐fire management treatments on the recruitment of a serotinous pine (Pinus pinaster) at a Mediterranean mountain. Treatments were applied 7 months after the fire and differ in the degree of intervention, ranging from “no intervention” (NI, all trees left standing) to “partial cut plus lopping” (PCL, felling most of the trees, cutting the main branches, and leaving all the biomass in situ without mastication), and “SL” (felling and piling the logs, and masticating the woody debris). Seedling survival after 3 years was the highest in PCL (47.3% versus 38.7% in SL). This was associated with the amelioration of microclimatic conditions under the scattered branches, which reduced radiation and soil temperature while increasing soil moisture. Seedling density after 2 years was approximately 5.5 times higher in PCL than in SL, as in SL a large fraction of seedlings was lost as a consequence of mechanized mastication. The NI treatment showed the lowest seedling survival (17.3%). Nevertheless, seedling density was similar to SL. Seedling growth scarcely differed among treatments. Our results show that branches left onsite acted as nurse objects that improved key microclimatic conditions for seedling recruitment. This creates a facilitative interaction ideal for seedling establishment in moisture‐deficient ecosystems, as it provides the benefit of a shading overstory but without underground competition.