Resource Reveals Molecular Classification Multiplatform Analysis of 12 Cancer Types within and across Tissues of Origin

Katherine A. Hoadley,1,20 Christina Yau,2,20 Denise M. Wolf,3,20 Andrew D. Cherniack,4,20 David Tamborero,5 Sam Ng,6 Max D.M. Leiserson,7 Beifang Niu,8 Michael D. McLellan,8 Vladislav Uzunangelov,6 Jiashan Zhang,9 Cyriac Kandoth,8 Rehan Akbani,10 Hui Shen,11,22 Larsson Omberg,12 Andy Chu,13 Adam A. Margolin,12,21 Laura J. van’t Veer,3 Nuria Lopez-Bigas,5,14 Peter W. Laird,11,22 Benjamin J. Raphael,7 Li Ding,8 A. Gordon Robertson,13 Lauren A. Byers,10 Gordon B. Mills,10 John N. Weinstein,10 Carter Van Waes,18 Zhong Chen,19 Eric A. Collisson,15 The Cancer Genome Atlas Research Network, Christopher C. Benz,2,* Charles M. Perou,1,16,17,* and Joshua M. Stuart6,* 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA 2Buck Institute for Research on Aging, Novato, CA 94945, USA 3Department of Laboratory Medicine, University of California San Francisco, 2340 Sutter St, San Francisco, CA, 94115, USA 4The Eli and Edythe Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA 5Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, Barcelona 08003, Spain 6Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064, USA 7Department of Computer Science and Center for Computational Molecular Biology, Brown University, 115 Waterman St, Providence RI 02912, USA 8The Genome Institute, Washington University, St Louis, MO 63108, USA 9National Cancer Institute, NIH, Bethesda, MD 20892, USA 10UT MD Anderson Cancer Center, Bioinformatics and Computational Biology, 1400 Pressler Street, Unit 1410, Houston, TX 77030, USA 11USC Epigenome Center, University of Southern California Keck School of Medicine, 1450 Biggy Street, Los Angeles, CA 90033, USA 12Sage Bionetworks 1100 Fairview Avenue North, M1-C108, Seattle, WA 98109-1024, USA 13Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada 14Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluı́s Companys, 23, Barcelona 08010, Spain 15Department of Medicine, University of California San Francisco, 450 35d St, San Francisco, CA, 94148, USA 16Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA 17Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA 18Building 10, Room 4-2732, NIDCD/NIH, 10 Center Drive, Bethesda, MD 20892 19Head and Neck Surgery Branch, NIDCD/NIH, 10 Center Drive, Room 5D55, Bethesda, MD 20892 20Co-first author 21Present address: Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, Oregon 97239-3098, USA 22Present address: Van Andel Research Institute, 333 Bostwick Avenue, Northeast, Grand Rapids, Michigan 49503, USA *Correspondence: cbenz@buckinstitute.org (C.C.B.), cperou@med.unc. edu (C.M.P.), jstuart@ucsc.edu (J.M.S.) http://dx.doi. org/10.1016/j.cell. 2014.06. 049