Miracle-dz/UniFAR-FTUs huggingface dataset:
On the use of two‐dimensional‐J NMR measurements for in Vivo proton MRS: Measurement of homonuclear decoupled spectra without the need for short echo times

The potential of two‐dimensional (2D)‐J NMR for in vivo proton MRS is examined. Single voxel measurements on the rat brain were performed at 4.7 T using point‐resolved spectrocopy localization with a voxel size of 64 μl and total measuring times of 10‐15 min. It is shown that a series of measurements with only 16 or fewer different echo times (TE) enables good signal localization in the f1 axis corresponding to the coupling patterns. For data evaluation, the 2D‐J NMR spectrum as well as cross‐sections at given f1 values and projections onto the f2 axis are used. A comparison between cross‐section spectra taken at different f1 values may help to solve problems of peak assignment. The projection of the 2D magnitude spectrum onto the f2 axis corresponds to a homonuclear decoupled 1D proton spectrum. Because the T2 relaxation times of several coupled resonances (e.g., myo‐inositol and glutamate) are rather long, only minor losses in the quality of the projection spectra occur if the measurements with short TE (≤ 50 ms) are not used for data processing. Thus, homonuclear decoupled proton spectra detecting uncoupled and several coupled resonances can be measured with high quality in vivo, even on MR systems that are not equipped with actively shielded gradients, prohibiting data acquisition with TEs of 50 ms or less.
GENDER DIFFERENCES IN STORIES OF EVERYDAY INTERNET USE

This study is a secondary analysis of data collected from four web-based focus groups of nurses and computer scientists who were frequent Internet users. Our aim in this secondary study was to examine gender differences and shared practices in the interpretation of narratives when using this technology. We found that women have different values than men when using the Internet. We can use this information to inform nurses of the gender values that are reflected in Internet usage to increase their understanding of the potential gender stereotyping practices that occur on a medium that is theoretically bias-free.
An Evaluation of Avian Influenza Diagnostic Methods with Domestic Duck Specimens

Abstract Monitoring of poultry, including domestic ducks, for avian influenza (AI) virus has increased considerably in recent years. However, the current methods validated for the diagnosis and detection of AI virus infection in chickens and turkeys have not been evaluated for performance with samples collected from domestic ducks. In order to ensure that methods for the detection of AI virus or AI virus antibody will perform acceptably well with these specimens, samples collected from domestic ducks experimentally infected with a U.S. origin low pathogenicity AI virus, A/Avian/NY/31588-3/00 (H5N2), were evaluated. Oropharyngeal (OP) and cloacal swabs were collected at 1, 2, 3, 4, 5, 7, 10, 14, and 21 days postinoculation (PI) for virus detection by virus isolation, which was considered the reference method, and real-time RT-PCR. In addition, two commercial antigen immunoassays were used to test swab material collected 2–7 days PI. Virus isolation and real-time RT-PCR performed similarly; however, the antigen immunoassays only detected virus during the peak of shed, 2–4 days PI, and both kits detected virus in fewer than half of the samples that were positive by virus isolation. Cloacal swabs yielded more positives than OP swabs with all virus detection tests. To evaluate AI virus antibody detection serum was collected from the ducks at 7, 14, and 21 days PI and was tested by agar gel immunodiffusion (AGID) assay, a commercial blocking enzyme-linked immunosorbent assay (ELISA), and homologous hemagglutination inhibition (HI) assay, which was used as the reference method. Results for the ELISA and HI assay were almost identical with serum collected at 7 and 14 days PI; however, by 21 days PI 100% of the samples were positive by HI assay and only 65% were positive by ELISA. At all time points AGID detected antibody in substantially fewer samples than either ELISA or HI assay.
Lecithin organogel as matrix for transdermal transport of drugs.

Organogels obtained by adding small amounts of water to a solution of lecithin in organic solvents were studied as matrices for the transdermal transport of drugs. Gels obtained from isopropyl palmitate and cyclooctane were used (molar ratios of water to lecithin of 3 and 12, respectively). Preliminarily histological studies showed that the gels have no harmful effect when applied to the skin for prolonged periods. Data relative to the stability of the organogels with time are also presented. Scopolamine and broxaterol were used as model drugs, and the transdermal experiments were done with a Franz diffusion cell and human skin obtained from plastic surgery. The transport rate of scopolamine obtained with the lecithin gels was about one order of magnitude higher than that obtained with an aqueous solution of the drug at the same concentration. In contrast, the transport rates of scopolamine obtained with the microemulsion solution prior to gelation (molar ratio of water to lecithin, 0) were not different from those obtained with the gel. The same variations in transport rates were observed for broxaterol, in which case the flux through the skin was directly proportional to the concentration of drug in the gel. At a concentration of broxaterol of 75 mg/mL in the donor gel, the flux was 47 micrograms.h-1.cm-2. Because preliminary results showed that transdermal transport is successful with amino acids and peptides also, it is concluded that lecithin gels may be efficient vehicles for the transdermal transport of various drugs.
Are Higher Education Institutions and Their Leadership Needs Unique? The Vertical versus Horizontal Perspective.

–––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– In what was characterized by many journalists and political pundits as the ‘age’ or ‘year of the outsider’ (Brooks, 2015; Fehrnstrom, 2015; Sexton, 2015) there was widespread interest in US presidential candidates with a diverse set of professional experiences and affiliations, including some with no experience in the political sector. At the same time, a number of institutions of higher education have both hired and in some cases subsequently terminated senior leaders with ‘outsider’credentials. Twenty percent of college presidents in the United States now come from fields outside academia, an increase from 13 percent just six years ago (Cook, 2012). The attraction of ‘outsider’ candidates for senior leadership positions may be inspired by the distinguished personal characteristics of a candidate, a perceived need for change within an institution or sector, or the emergence of a more generic view as to the nature of competencies required for outstanding leadership. Whatever the motivations and rationale underpinning such decisions, these actions raise interesting questions about the extent to which particular sectors and institutions within them, along with the set of competencies required to lead them, are truly unique. Considering these issues from the perspective of higher education, two questions are considered in this conceptual article: (1) are colleges and universities unique as organizations as has long been a widely-held view within the academy; and (2) to what extent are the capabilities that are necessary for effective leadership in higher education unique?
Innovation, productivity, exports and the investment climate: A study based on Indian manufacturing firm-level data

We study the interactions between firm-level innovation, productivity and exports in the case of the Indian manufacturing sector. To differentiate the incentives to innovate from the ability to innovate, we distinguish the inputs of innovation (R&D and training), from the outputs. Our findings highlight a virtuous circle between the three components of innovation, as well as between firm-level R&D, innovation and exports. The results suggest a positive effect of R&D on innovation (product innovation in particular), of innovation on exports (product and marketing innovation especially), and of exports on R&D. Furthermore, it seems that training and R&D reinforce each other in the Indian firm-level innovation process: doing R&D incites firms to train their workforce, and training stimulates R&D in return. Productivity of the Indian manufacturing firms seems to benefit from that dynamics, as exporting and innovating would improve firm-level TFP. As for the investment climate, our results suggest that the differences in the Indian firm-level environment participate in the firms' performance gaps. These results are all the more important in the context of the Make in India campaign and the business environment deficiencies.
Physicians’ attitudes towards euthanasia in Finland: would training in palliative care make a difference?

Euthanasia is currently not legal in Finland, but discussions about legalization have recently been conducted among the general public. There are concerns that adequate care in end-of-life should be available in the light of an increasing number of elderly people with terminal disease. When treating incurable patients in end-of life situations physicians are often confronted with complex decisions which can evoke strong emotions and distress. This can be difficult to manage without proper training in communication and symptom management. In Finland palliative care is becoming established and re-organized. This survey evaluated the views, fears and needs for training among Finnish physicians representing different specialities being responsible for end-oflife care.
Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients

Abstract Background. Irritable bowel syndrome (IBS) is characterized by chronic abdominal symptoms such as pain, discomfort, and altered bowel habits. A subset of IBS patients, denoted as post-infectious IBS (PI-IBS) patients, develop symptoms after an enteric infection. Distinct abnormalities in the gut mucosa, including mucosal inflammation, have been proposed to contribute to or be the cause of PI-IBS. This study investigated lymphocyte subsets in PI-IBS patients compared to healthy controls. Materials and methods. Ten PI-IBS patients and nine healthy controls participated. All PI-IBS patients met the Rome III diagnostic criteria for IBS and reported sustained symptoms at least 1 year after an episode of acute gastroenteritis. Intraepithelial lymphocytes and lamina propria lymphocytes (LPLs), isolated from mucosal tissue samples, were stained and analyzed for a comprehensive set of cell markers using flow cytometry. Results. The number of LPLs in PI-IBS was significantly increased compared to those in healthy controls (p < 0.05). PI-IBS patients showed significantly increased proportions of CD45RO+ CD4+ activated/memory T cells (p < 0.05) and double-positive CD4+ CD8+ cells (p < 0.05), respectively, in the lamina propria. The number of CD19+ LPLs was decreased in PI-IBS patients compared to healthy controls (p < 0.001). Conclusion. This study presents new evidence that PI-IBS is associated with a sustained aberrant mucosal immune response and support future studies of anti-inflammatory or immune-modulating treatments in these patients.
Analysis and Design of H&#8734;Feedback Control Systems with Two Quantized Signals

In this paper, we consider analysis and design of Hinfin feedback control systems with two quantized signals. We assume that a state feedback has been designed for a continuous-time LTI (linear time-invariant) system so that the closed-loop system is Hurwitz stable and a desired Hinfin disturbance attenuation level is achieved. However, the states are quantized before they are passed to the controller, and the control inputs are quantized before they reach the system. For such quantized feedback control systems, we propose a state-dependent strategy for updating the quantizers' parameters, so that the system is asymptotically stable and achieves the same Hinfin disturbance attenuation level. We also extend the discussion to the case of static output feedback where the measured outputs are quantized
Cognitive Functioning in Gulf War Illness

A comprehensive neuropsychological battery was administered to 48 veterans with Gulf War Illness (GWI) characterized by severe fatigue (GV-F) and 39 healthy veterans (GV-H). Subjects were matched on intelligence and did not differ on age, gender, race, and alcohol consumption. Compared to GVs-H, GVs-F were significantly impaired on four tasks: three attention, concentration, information processing tasks and one measure of ion and conceptualization. After considering the presence of post-war Axis I psychopathology, GWI remained a significant predictor of cognitive performance on one of the attention, concentration, and information processing tasks and one abstraction and conceptualization measure. Performance on the remaining two attention, concentration, and information processing tasks was only significantly predicted by Axis I psychopathology with post-war onset. The results suggest that Gulf War Illness is associated with some aspects of cognitive dysfunction in Gulf Veterans, over and above the contribution of psychopathology.
Biogeography and phylogenetic position of Enchodeloides signyensis (Loof, 1975), gen. n., comb. n. from Maritime Antarctic (Nematoda, Nordiidae)

Abstract The taxonomic position of the endemic Antarctic species Enchodeloides signyensis (Loof, 1975), gen. n. , comb. n. (= Enchodelus signyensis Loof, 1975) is discussed on the basis of morphological study, including SEM, morphometric data, postembryonic observations, and sequence data of 18S rDNA and the D2-D3 expansion fragments of the large subunit rDNA. A number of characters such as the cuticle and stoma structures, including the presence of moderately developed cuticularised ring around the oral aperture, peculiarities of pharynx expansion, size and position of the posterior pair of pharyngeal nuclei, a less complex uterus, and the position of a posterior ventromedian supplement show that this species differs substantially from the other members of the genus Enchodelus. Furthermore, both the 18S and 28S rDNA-based phylogenetic trees of the Enchodelus sequences available in the GenBank formed two distinct clusters with E. signyensis being a part of a well-supported group with species of the genus Pungentus; therefore, it is proposed that its taxonomic position should be reconsidered.
The Stress Response to Surgery and Postoperative Delirium

Introduction: The aim of this study is to determine whether postoperative delirium is associated with dysregulation of hypothalamic–pituitary–adrenal and growth hormone/insulin-like growth factor 1 (GH/IGF-1) responses following acute systemic inflammation. Methods: Plasma levels of cortisol, IGF-1, C-reactive protein, interleukin (IL)-6, IL-8, and IL-10 were measured before and after surgery in 101 patients ≥60 years without dementia undergoing elective hip arthroplasty. Participants were assessed with confusion assessment method and Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revision; DSM-IV-TR) postoperatively and 37 patients fulfilled the DSM-IV-TR criteria for delirium. Results: Preoperative plasma cortisol levels were similar in delirium and nondelirium groups (405.37 ± 189.04 vs 461.83 ± 219.39; P = .22). Participants with delirium had higher postoperative cortisol levels (821.67 ± 367.17 vs 599.58 ± 214.94; P = .002) with enhanced postoperative elevation in relation to baseline (1.9- vs 1.5-fold; P = .004). The plasma levels of IGF1 did not differ in delirium and nondelirium groups before (18.12 ± 7.58 vs 16.8 ± 7.86; P = .477) and following surgery (13.39 ± 5.94 vs 11.12 ± 6.2; P = .639), but the levels increased in relation to baseline more frequently in patients who developed delirium (24.3% vs 7.8%; P = .034). The magnitude of postoperative cortisol elevation correlated with ΔIL-6 (P = .485; P = .002), ΔIL-8 (P = .429; P = .008), and ΔIL-10 (P = .544; P < .001) only in patients with delirium. Conclusions: Hypothalamic–pituitary–adrenal axis hyperresponsiveness and a less frequent suppression of the GH/IGF-1 axis in response to acute stress are possibly involved in delirium pathophysiology.
Characterization of mENT1Δ11, a Novel Alternative Splice Variant of the Mouse Equilibrative Nucleoside Transporter 1

Mammalian cells require specific transport mechanisms for the cellular uptake and release of endogenous nucleosides such as adenosine, and nucleoside analogs used in chemotherapy. We have identified a novel splice variant of the mouse equilibrative nucleoside transporter, mENT1, that results from the exclusion of exon 11 during pre-RNA processing. This variant encodes a truncated protein (mENT1Δ11) missing the last three transmembrane domains of the full-length mENT1. The mENT1Δ11 transcript and protein were found to be differentially distributed among tissues relative to full-length mENT1. PK15-NTD (nucleoside transport deficient) cells were transfected with mENT1 or mENT1Δ11 and assessed for nucleoside transport function. No significant differences were observed between the mENT1 and mENT1Δ11 in terms of transport function or inhibitor binding affinity. PK15-mENT1Δ11 transfected cells bound the ENT1 probe [3H]nitrobenzylthioinosine (NBMPR) with high affinity and mediated the cellular accumulation of both [3H]2-chloroadenosine and [3H]uridine. The only significant differences between the mENT1 variants were that mENT1Δ11 could not be photolabeled with [3H]NBMPR and that mENT1Δ11 was insensitive to the transporter-modifying effects of N-ethylmaleimide. These data suggest that the last three transmembrane domains of mENT1 are not necessary for transport activity, but this region does contain the cysteines responsible for the sensitivity of mENT1 to sulfhydryl reagents, and the residues important for covalent modification of the protein with NBMPR. These results provide important guidelines for future mutagenesis studies aimed at elucidating the tertiary structure of the ENT1 protein and the domains involved in inhibitor binding and substrate translocation.
Allometric Scaling in the Earliest Archaeopteryx lithographica

Archaeopteryx is almost universally considered a primitive bird. Debate persists, however, about the taxonomic assignment of the six skeletal fossils. Allometric scaling of osteological data shows that all specimens are consistent with a single growth series. The absence of certain bone fusions suggests that no specimen is full-grown. Allometric patterns, as compared to growth gradients of other dinosaurs, extant ectotherms, and extant endotherms, suggest that Archaeopteryx was likely a homeothermic endotherm with rapid growth and precocial abilities for running and flying. Multivariate allometric models offer a significant potential for interpreting ontogenetic patterns and phylogenetic trends in the fossil record.
Unemployment Persistence , Inflation and Monetary Policy , in a Dynamic Stochastic Model of the “ Natural Rate ”

This paper analyzes monetary policy in the context of a small dynamic stochastic general equilibrium model of the “natural rate” characterized by endogenous unemployment persistence. The model is based on one period nominal wage contracts and wage setting by labor market “insiders”. Product and financial markets are assumed perfectly competitive. The persistence of unemployment results in persistent inflation as, under the Taylor rule, the central bank responds systematically to persistent deviations of unemployment from its natural rate. Inflation persists, even though prices are fully flexible. The analysis provides an equilibrium interpretation of the persistence or real and nominal aggregates in the United States.
Updated survey of Fusarium species and toxins in Finnish cereal grains

ABSTRACT The aim of the project was to produce updated information during 2005–14 on the Fusarium species found in Finnish cereal grains, and the toxins produced by them, as the last comprehensive survey study of Fusarium species and their toxins in Finland was carried out at the turn of the 1960s and the 1970s. Another aim was to use the latest molecular and chemical methods to investigate the occurrence and correlation of Fusarium species and their mycotoxins in Finland. The most common Fusarium species found in Finland in the FinMyco project 2005 and 2006 were F. avenaceum, F. culmorum, F. graminearum, F. poae, F. sporotrichioides and F. langsethiae. F. avenaceum was the most dominant species in barley, spring wheat and oat samples. The occurrence of F. culmorum and F. graminearum was high in oats and barley. Infection by Fusarium fungi was the lowest in winter cereal grains. The incidence of Fusarium species in 2005 was much higher than in 2006 due to weather conditions. F. langsethiae has become much more common in Finland since 2001. F. graminearum has also risen in the order of importance. A highly significant correlation was found between Fusarium graminearum DNA and deoxynivalenol (DON) levels in Finnish oats, barley and wheat. When comparing the FinMyco data in 2005–06 with the results of the Finnish safety monitoring programme for 2005–14, spring cereals were noted as being more susceptible to infection by Fusarium fungi and the formation of toxins. The contents of T-2 and HT-2 toxins and the frequency of exceptionally high DON concentrations all increased in Finland during 2005–14. Beauvericin (BEA), enniatins (ENNs) and moniliformin (MON) were also very common contaminants of Finnish grains in 2005–06. Climate change is leading to warmer weather, and this may indicate more changes in Finnish Fusarium mycobiota and toxin contents and profiles in the near future.
Statistics of gradient directions in natural images

Interest in finding statistical regularities in natural images has been growing since the advent of information theory and the advancement of the efficient coding hypothesis that the human visual system is optimised to encode natural visual stimuli. In this thesis, a statistical analysis of gradient directions in an ensemble of natural images is reported. Information-theoretic measures have been used to compute the amount of dependency which exists between triples of gradient directions at separate image locations. Control experiments are performed on other image classes: phase randomized natural images, whitened natural images, and Gaussian noise images. The main results show that for an ensemble of natural images the average amount of de pendency between two and three gradient directions is the same as for an ensemble of phase randomized natural images. This result does not extend to i) the amount dependency between gradient magnitudes, ii) gradient directions at high gradient magnitude locations, or iii) individual natural images. Furthermore, no significant synergetic dependencies are found between triples of gradient directions in an ensemble natural images a synergetic dependency is an increase in dependency between a pair of gradient directions given the interaction of a third gradient direction. Additional experiments are performed to establish both the generality and specificity of the main results by studying the gradient direction dependencies of ensembles of noise (random phases) images with varying power law power spectra. The results of the additional experiments indicate that, for ensembles of images with varying power law power spectra, the amount of dependency between two and three gradient directions is determined by the ensemble's mean power spectrum rather than the phase spectrum. A framework is also presented for future work and preliminary results are provided for the dependency between second order derivative measurements (shape index) for up to 9-point configurations.