Miracle-dz/UniFAR-FTUs huggingface dataset:
Free school meals in secondary schools in Wales; a socio ecological examination of policy implementation and the take up of entitlement

Free school meal provision in the UK has a long history, representing an important mechanism to tackle child poverty, address inadequate diets and tackle childhood obesity. However, concern revolves around levels of non-take up, since a significant proportion of those entitled don’t register, or once registered, don’t consume the meal. The take up of entitlement varies by Local Authority, indicating the impact of the local context. Existing research has identified a range of influential factors but by seeking to isolate factors, such an approach overlooks why these factors exist, how they are interrelated and why they affect the people they do. This study uses a collective lifestyles approach to explore the social context of free school meal provision to understand the interaction between policy, context and the individual and the influence of these interactions on uptake of entitlement. Using a case study methodology, four schools within one Local Authority in Wales were examined; data were collected by a review of policy documents, focus groups with pupils and interviews with policy makers, stakeholders, local authority and school staff and parents and pupils. Underpinned by a socio ecological framework, factors at a range of analytical levels were examined. Free school meal policy has been shaped by historical and structural factors, including devolution and this influences implementation at the local level. For pupils, issues associated with the school food environment, food availability, the built environment and the social processes of school dining influence the likelihood of having school meals and for pupils on free school meals, the ability to conform to peer norms is shaped by marginalisation, influencing the uptake of entitlement. Recommendations focus on minimising marginalisation by ensuring confidentiality throughout school processes and ensuring that free school meal pupils can participate in the same school food practices as the wider pupil population.
Rehabilitation Therapies After Botulinum Toxin-A Injection to Manage Limb Spasticity: A Systematic Review

Background Botulinum toxin A (BoNT-A) injections are increasingly used to treat muscle spasticity and are often complemented by adjunctive rehabilitation therapies; however, little is known about the effect of therapy after injection. Purpose The aim of this study was to identify and summarize evidence on rehabilitation therapies used after BoNT-A injections to improve motor function in adults with neurological impairments. Data Sources Searches were conducted in PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, National Research Register, metaRegistry of Controlled Trials, PEDro, and OTseeker. Study Selection Randomized and quasi-randomized controlled trials were considered for inclusion. Participants with neurological impairments received BoNT-A to treat focal spasticity in limbs, with rehabilitation interventions provided to experimental groups only. Primary outcome measures were joint mobility, function of the affected limb, and spasticity. Eleven studies with 234 participants, most of whom had stroke, were included in the review. Data Extraction Two reviewers extracted study details and data. Data Synthesis Methodological quality was rated using the PEDro scale. Both fixed-effects and random-effects models were used to calculate effect size. Results Studies were of variable quality: 3 were poor (PEDro score 1 to 4), and 8 were moderate (PEDro score 6 to 7). No study investigated effects for longer than 24 weeks (6 months). Included trials presented 9 therapy types, including ergometer cycling, electrical stimulation, stretch (casting, splinting, taping, or manual or exercise-induced stretch), constraint-induced movement therapy, task-specific motor training, and exercise programs. Statistical findings suggest that combined therapy and BoNT-A is slightly more effective than BoNT-A alone. Conclusion Evidence relating to impact of adjunct therapy is available, but the heterogeneity of studies limits the opportunity to demonstrate overall impact. Researchers need to consider the benefits of greater consistency in study approaches and measures so that meaningful evaluations of overall adjunct therapy effects can be made.
What Price The Moral High Ground

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Decreased brain edema after collagenase-induced intracerebral hemorrhage in mice lacking the inducible nitric oxide synthase gene. Laboratory investigation.

OBJECT Hematoma size and brain edema after intracerebral hemorrhage (ICH) are important prognostic factors. Inducible nitric oxide synthase (iNOS) is induced after cerebral ischemia and is known to be involved in secondary neuronal injury, but its significance in ICH is unknown. The authors tested whether iNOS would influence hematoma size and brain edema after ICH. METHODS The authors used C57BL/6 and iNOS knockout mice for all the experiments. Experimental ICH was induced by the intrastriatal stereotactic administration of bacterial collagenase. Brain tissue was obtained at 72 hours after ICH. The volume of hematoma was quantified by spectrophotometric assay, and the brain water content was measured. The investigators also measured blood-brain barrier permeability using Evans blue dye. RESULTS There was no significant difference in hematoma size between the 2 groups. The brain water content of the lesional hemisphere was higher in C57BL/6 mice than in iNOS knockout mice. More Evans blue leakage in the brain was observed in C57BL/6 control mice than in iNOS knockout mice. Immunohistochemistry showed iNOS immunoreactivity in the perihematoma areas of C57BL/6 mice but not in the iNOS knockout mice. CONCLUSIONS When hematoma size was similar, iNOS knockout mice had significantly less brain edema than their littermates. These results suggest that iNOS modulation might become an antiedematous therapy for ICH.
Nanosized structures with the field localization: New opportunities for precise control of photonic and electronic devices

This paper describes the results of research in the tunnel photoelectric effect in microdiode with the localization of an electrostatic field at the emitter of carbon nanosized structure. It is experimentally found that irradiation of carbon emitter by photon beams with low energy (less than the work function) within the spectral range 380 - 1550 nm and with micro- and milliwatt optical power may initiate tunneling of photocurrent by controlling the field intensity in the gap “anode - emitter”. The peculiarities of the design and application of photonic and electronic devices using an photoelectric effect with “red” threshold are discussed. The estimation of investigated photoemitter broadbandness is made, an opportunity to work in a range of wavelengths from ultraviolet up to far infrared is predicted. A method for controlling a tunneling current of emission by changing the optical power density is suggest. In this case, the voltage-current characteristic becomes a linearly dependent on the level of optical power density, which ensures stability of controlling.
Relationship between wheat characteristics and nutrient digestibility in broilers: comparison between total collection and marker (titanium dioxide) technique.

Three wheat cultivars (Orpheus, Rustic, and Viscount) were used to formulate 3 test feeds (62.4% wheat) in a broiler digestibility trial. The diets were fed to male Ross 308 broiler chickens. The wheat cultivars mainly differed in their amount of non-starch polysaccharides ( NSP: ). The cultivar Orpheus was chosen to represent a high amount of NSP (102 g/kg DM), whereas the cultivars Rustic and Viscount represented low amounts of NSP (83.4 g/kg DM and 73.9 g/kg DM, respectively). Furthermore, the cultivars Orpheus and Viscount were feed quality wheat, whereas Rustic was a milling quality wheat. Nutrient digestibilities and AMEn contents of the diets were measured from 18 to 22-days-old by total excreta collection, or with the use of the indigestible marker titanium dioxide. In addition, the ileal viscosity was measured when the broilers were 25-days-old. Wheat cultivar affected N retention, DM digestibility, and AMEn. In general, the feed formulated with the high NSP wheat cultivar Orpheus resulted in the least favorable nutrient digestibilities and AMEn, whereas the results were better when the feed was formulated with the low NSP cultivars Viscount and Rustic. Feeding the Rustic cultivar caused the highest intestinal viscosity, although this was not reflected in the animal responses. Nutrient digestibilities and AMEn content of the diets were lower when calculated with the titanium dioxide marker than with the total excreta collection procedure. Moreover, the P-values of the effect of wheat cultivar on DM digestibility, N retention, crude fat digestibility and AMEn were lower with the use of the titanium dioxide marker. It can be concluded that wheat cultivar affected nutrient digestibility and AMEn, and that the observed differences were related to the amount of NSP. Furthermore, both the titanium dioxide marker and the total excreta collection methods showed the same trends despite the different values obtained. The titanium dioxide marker method was the simplest to use and produced valid results.
Predictive accuracy of Goodsall’s rule for fistula-in-ano

Introduction Successful treatment of fistula-in-ano is sometimes challenging due to difficulty in recognising the internal opening and the course of the fistula tract. Although Goodsall’s rule was accepted in the past, as a method to determine the course of the fistula, recent data have shown conflicting results. Objectives To study the predictive accuracy of Goodsall’s rule. Methods A sample of 212 patients with simple fistulae were studied. Hydrogen peroxide was injected through the external opening and the appearance of air bubbles in the anal canal indicated the location of the internal opening. The morphological parameters including the site and number of internal and external opening/s and the course of the tract were recorded. Results The median age of the participants was 39 (range, 18-78) years. The majority (n=167, 78.8%) were males. Of the study group, 63 (29.7%) had inter-sphincteric fistulae, 114 (53.8%) transphincteric fistulae and 35 (16.5%) superficial fistulae. The overall predictive accuracy of Goodsall’s rule in our patients was 78.3%. Predictive accuracy was significantly associated with type of fistulae with high predictive accuracy seen in superficial fistulae (97.1%) and inter-sphincteric fistulae (84.1%) compared to transphincteric fistulae (69.3%) (p=0.001). Predictive accuracy was significantly higher in those with an external opening in the midline (98.2%), (p<0.001). Conclusions Although Goodsall’s rule was not accurate in 22% of all fistulae, it can be used as a guide in locating the path of the tract and the internal opening in simple fistulae.
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

Polycomb Group (PcG) and Trithorax Group (TrxG) proteins are key epigenetic regulators of global transcription programs. Their antagonistic chromatin-modifying activities modulate the expression of many genes and affect many biological processes. Here we report that heterozygous mutations in two core subunits of Polycomb Repressive Complex 2 (PRC2), the histone H3 lysine 27 (H3K27)-specific methyltransferase E(Z) and its partner, the H3 binding protein ESC, increase longevity and reduce adult levels of trimethylated H3K27 (H3K27me3). Mutations in trithorax (trx), a well known antagonist of Polycomb silencing, elevate the H3K27me3 level of E(z) mutants and suppress their increased longevity. Like many long-lived mutants, E(z) and esc mutants exhibit increased resistance to oxidative stress and starvation, and these phenotypes are also suppressed by trx mutations. This suppression strongly suggests that both the longevity and stress resistance phenotypes of PRC2 mutants are specifically due to their reduced levels of H3K27me3 and the consequent perturbation of Polycomb silencing. Consistent with this, long-lived E(z) mutants exhibit derepression of Abd-B, a well-characterized direct target of Polycomb silencing, and Odc1, a putative direct target implicated in stress resistance. These findings establish a role for PRC2 and TRX in the modulation of organismal longevity and stress resistance and indicate that moderate perturbation of Polycomb silencing can increase longevity.
Influenza-B-Virus-Induced Eye and Brain Malformations during Early Chick Embryogenesis and Localization of the Viral RNA in Specific Areas

Influenza is prevalent worldwide, and the teratogenic effects of influenza infection have been suspected to occur within the developing central nervous system. We herein report the sequelae of influenza B viral infection during early chick embryogenesis. Chick embryos at Hamburger-Hamilton stage 9 were infected by an in ovo injection under the blastoderm of influenza B virus (B/Taiwan/25/99). At 48 h after infection, gross malformations of the eye and brain, ranging from 25 to 58% of 168 infected embryos, were observed, in contrast to 3–6% among 71 mock-infected controls (p < 0.0001 for both eye and brain malformations). Histological analyses showed extensive tissue degeneration and aggregates of cells in the head mesenchyme, suggesting cell death and heterotopia. Influenza B viral RNA was directly localized by in situ hybridization with probes specific for the HA segment. Viral RNA was extensively detected in the head surface ectoderm and in the lung bud. In the developing brain, viral RNA was specifically located in the anterior neural retina, habenular area, mid-thalamus, and rhombencephalon. Our data show that influenza B virus can be a teratogenic agent in neural and nonneural embryonic tissues, raising concern for transplacental infection during early pregnancy.
The first branching point in porphyrin biosynthesis: A systematic docking, molecular dynamics and quantum mechanical/molecular mechanical study of substrate binding and mechanism of uroporphyrinogen‐III decarboxylase

In humans, uroporphyrinogen decarboxylase is intimately involved in the synthesis of heme, where the decarboxylation of the uroporphyrinogen‐III occurs in a single catalytic site. Several variants of the mechanistic proposal exist; however, the exact mechanism is still debated. Thus, using an ONIOM quantum mechanical/molecular mechanical approach, the mechanism by which uroporphyrinogen decarboxylase decarboxylates ring D of uroporphyrinogen‐III has been investigated. From the study performed, it was found that both Arg37 and Arg50 are essential in the decarboxylation of ring D, where experimentally both have been shown to be critical to the catalytic behavior of the enzyme. Overall, the reaction was found to have a barrier of 10.3 kcal mol−1 at 298.15 K. The rate‐limiting step was found to be the initial proton transfer from Arg37 to the substrate before the decarboxylation. In addition, it has been found that several key interactions exist between the substrate carboxylate groups and backbone amides of various active site residues as well as several other functional groups. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2011.
A Research Note on the Relationship Between Long Working Hours and Weight Gain for Older Workers in the United States

Working long hours may be related to obesity in older adults. No studies have focused on older workers and long work hours, although the risk of obesity is high among this population group. This study is the first attempt to investigate the relationship between obesity and the older workforce. Panel data from the Health and Retirement Study are examined using Cox regression techniques. We found that older workers who work more than 59 hr a week are more likely to gain weight than older workers who work less than 59 hr per week.
A methodological study of computerized venous strain‐gauge plethysmography of the upper extremities

This study was performed to assess the efficiency of computerized strain‐gauge plethysmography for evaluation of venous volume (VV) and outflow capacity of the upper extremities and to receive reference values. For this purpose, we investigated 34 healthy controls; 16 males and 18 females with a mean age of 45 years (range 31–58 years). These results were compared with those obtained in 32 patients with earlier spontaneous deep venous thrombosis (DVT) in the upper extremities. In the control group, there was no difference between right and left arm and none of the variables were influenced by age and gender. Venous volume and rate of venous emptying (VE) were significantly lower in arms with earlier DVT than in those without (VV: DVT arms 3·7 ± 0·96 ml 100ml−1 and controls 4·6 ± 0·81 ml 100ml−1; VE: DVT arms 79 ± 24 ml 100ml−1 min−1 and controls 110 ± 21 ml 100ml−1 min−1). Repeated measurements had a coefficient of variation of approximately 10% in both groups. We found the device easy to handle and the results demonstrates that this is a useful method to study venous function in upper extremities. This implicates that computerized strain‐gauge plethysmography is an efficient method both for clinical diagnostic routine and research studies of circulatory changes in acute and chronic DVT in the upper extremity.
Complementation of an Escherichia coli DnaK Defect by Hsc70-DnaK Chimeric Proteins

ABSTRACT Escherichia coli DnaK and rat Hsc70 are members of the highly conserved 70-kDa heat shock protein (Hsp70) family that show strong sequence and structure similarities and comparable functional properties in terms of interactions with peptides and unfolded proteins and cooperation with cochaperones. We show here that, while the DnaK protein is, as expected, able to complement an E. coli dnaK mutant strain for growth at high temperatures and λ phage propagation, Hsc70 protein is not. However, an Hsc70 in which the peptide-binding domain has been replaced by that of DnaK is able to complement this strain for both phenotypes, suggesting that the peptide-binding domain of DnaK is essential to fulfill the specific functions of this protein necessary for growth at high temperatures and for λ phage replication. The implications of these findings on the functional specificities of the Hsp70s and the role of protein-protein interactions in the DnaK chaperone system are discussed.
Detection of circulating free and complexed staphylococcal antigens by enzyme-linked immunosorbent assay

An enzyme-linked immunosorbent assay was developed for the detection of circulating free and complexed staphylococcal antigens in various clinical categories of staphylococcal infections. Circulating immune complexes were studied by the polyethylene glycol precipitation method. Circulating immune complexes and staphylococcal antigen (at titers of greater than or equal to 1:32) dissociated from the complexes were found in 7 of 8 patients (87.5%) with staphylococcal endocarditis and in 4 of 20 patients with staphylococcal bacteremia (20%). Although the majority of patients did not have detectable free staphylococcal antigen, it was found in three patients with staphylococcal pneumonia. We conclude that detection of complexed antigen in high titer may differentiate patients with staphylococcal endocarditis from those with other forms of staphylococcal infection or transient bacteremia.
Prevalence of gingival biotype and its relationship to dental malocclusion.

OBJECTIVE To study the prevalence of different gingival biotypes in a sample of patients and the association between gingival biotype and different dental malocclusions. METHODS Two hundred adult patients (100 males and 100 females) who presented for treatment at the Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia were recruited from February 2011 to February 2012. Gingival thickness was assessed for the maxillary central incisors using the transparency of periodontal probe technique. Angle's classification of malocclusion and smoking habit were also recorded. RESULTS The mean age was 32.1 (+/-11.0) years. Thin gingival biotype was observed in 44.5% of the sample, of which 64% were females and 25% were males (p=0.001). Only 31.4% of current smokers had thin gingival biotype compared to 51.9% of subjects who never smoked (p=0.011). No significant association between dental malocclusions and the presence of thin gingival biotype was found (Class I = 42.9%, Class II = 44.1%, and Class III 53.9%, p=0.6). CONCLUSION A high prevalence of thin gingival biotype especially among females was observed. Smokers had thicker gingival biotype. No relationship was found between gingival biotypes and Angle's classification of malocclusion.
Profile of Heart Donors from the Human Valve Bank of the Santa Casa de Misericórdia de Curitiba

Introduction Human heart valves are used as replacement valves and have satisfactory functional results compared with conventional prostheses. Objective Characterize the profile of effective heart donors from the human valve bank of the santa casa de misericórdia de curitiba and analyze the association between the profile variables. Methods It consists of a retrospective and quantitative study of electronic medical records from heart donors for heart valves. every heart donation made to the bank between january 2004 and december 2014 was studied. Results 2,149 donations were analyzed, from donors aged 0 to 71 years old, with an average of 34.9 ± 15.03 years old. most donors were male 65.7% (n=1,411) and 34.3% (n=738) were female. among the most frequent causes of the donors' death are trauma at 53% (n=1,139) and cerebral vascular accident at 34.2% (n=735). there was significant statistical association between the analyzed variables. Conclusion There has been an improvement in brazil's donation rate, being essential that the tissue banks work together with the state and federal district centers for notification, procurement and distribution of organs in order to increase the number of donors.
Schizophrenia and the myth of intellectual decline.

OBJECTIVE The authors' goal was to investigate the issue of intellectual deterioration in schizophrenia. METHOD They examined the childhood IQs of adult patients with schizophrenia who had attended a child psychiatry service where measurement of intelligence was routine. Follow-up IQs of 34 of these patients were obtained an average of 19.4 years later. RESULTS The mean child and adult IQs were greater than one standard deviation lower than those of the general population. There were no significant differences between the child and adult IQs, however, suggesting that the impairment in intelligence during childhood was stable over the follow-up period. CONCLUSIONS The deficit in intellectual function observed in these patients, and reported in the literature, is lifelong and predates the onset of schizophrenia.