Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding the importance of food tourism to Chongqing, China

Food is widely accepted as of great importance in tourists’ experiences by researchers. However, few studies allow tourists themselves to indicate the importance of food for their travel. In the meanwhile, the argument regarding the overestimation of the importance of food tourism to attract tourists is on the increase. Through a case study in Chongqing (China), this study aims to critically assess the importance of food tourism from domestic tourists’ perspectives. In particular, it fills the gap by providing a thorough exploration of tourists’ food experiences at different stages of their travel. A quantitative research methodology involving a structured questionnaire has been adopted. The results reveal that food plays different roles in different travel stages. The importance of food tourism in the pre-travel stage to Chongqing is not as important as the existing literature sources suggest. However, food has shown its importance during tourists’ travel in Chongqing as well as increased importance in their post-travel stage. In light of these findings, marketing strategies can be identified to accelerate the development of food tourism at a destination.
Investor Sentiment and the Cross-Section of Stock Returns

We investigate whether investor sentiment affects the cross-section of stock returns in China A-share market.The evidence shows that the sensitivity of stock returns to sentiment changes is different. When an index of investor sentiment takes high values,low tangible assets,high Debt-asset ratio,and non-dividend-paying stocks earn relatively higher returns,when sentiment is low,the aforementioned categories of stocks earn relatively lower returns.When sentiment is high,low-price,unprofitable and high book-market ratio stocks earn relatively higher returns and vice versa,but which is insignificant.The capitalization, volatility and institutional ownership appear to have no significant cross-section effect of investor sentiment on its characteristic Portfolio return.
Financial development, control of corruption and income inequality

Abstract This paper examines the effect of financial development and control of corruption on income inequality in 21 Sub-Saharan African (SSA) countries over the period 1985–2011 using the pooled mean group (PMG) estimator. The empirical results show that financial development measures have positive impact on income inequality, which suggest that financial development increases income inequality. On the other hand, the coefficients of control of corruption are negative and significantly related to income inequality which implies that corruption control reduces income inequality. Further, the interaction of the financial development and the control of corruption is found to be negatively and significantly related to income inequality. Equally the interaction of the financial development and transparency index (an alternate measure of corruptibility) is found to be negatively and significantly related to income inequality. These findings suggest that the control of corruption and transparency in governance are crucial in reducing income inequality in SSA.
Effects of multiple doses of ionizing radiation on cytokine expression in rat and human cells

Purpose: To determine the effect of daily fractionated irradiation on the expression of growth factors and cytokines in different cardiac and vascular cell types. Materials and methods: Cell cultures of rat cardiac myocytes, fibroblasts, a rat cardiac microvascular endothelial cell line and human artery endothelial cells were irradiated with doses of 2 Gy, given daily during 5 consecutive days. Twenty‐four hours after each fraction, gene expression was determined by competitive or semiquantitative polymerase chain reaction. Protein secretion into culture media was determined by enzyme‐linked immunoabsorbant assay. Results: Of all investigated mRNA levels, transforming growth factor (TGF)‐ß1 and fibroblast growth factor (FGF)‐2 were slightly upregulated in the rat cardiac endothelial cell line after irradiation. TGF‐ß1 protein secretion by these cells was slightly, but non‐significantly, elevated. Interleukin 1ß protein levels in myocyte culture media were decreased in control cultures at days 3 and 4 compared with day 2. No significant changes were observed in expression of FGF‐2 in either of the four cell types. Moreover, no changes were observed in gene expression of platelet‐derived growth factors A, B and interleukin 8 in the human artery endothelial cells. Conclusions: Fractionated irradiation leads to minor changes in the expression of specific cytokines in cardiac myocytes, fibroblasts and endothelial cells.
Roaccutane treatment guidelines: results of an international survey.

BACKGROUND Oral isotretinoin (Roaccutane) revolutionized the treatment of acne when it was introduced in 1982. METHODS Twelve dermatologists from several countries with a special interest in acne treatment met to formally review the survey of their last 100 acne patients treated with oral isotretinoin. The primary purpose of the survey was to identify the types of acne patients who were prescribed oral isotretinoin and how the patients were managed. RESULTS Of the 1,000 patients reviewed, 55% of those who received oral isotretinoin had those indications treated historically, i.e. severe nodular cystic acne or severe inflammatory acne, not responding to conventional treatment. Forty-five percent of patients who were prescribed oral isotretinoin however had either moderate or mild acne. Most patients in this group had moderate acne (85%). However, 7.3% had mild acne on physical examination. The criteria for prescribing oral isotretinoin in this less severe group of patients included acne that improves < 50% after 6 months of conventional oral antibiotic and topical combination therapy, acne that scars, acne that induces psychological distress and acne that significantly relapses during or quickly after conventional therapy. Treatment is usually initiated at daily doses of 0.5 mg/kg (but may be higher) and is increased to 1.0 mg/kg. Most of the physicians aimed to achieve a cumulative dose of > 100-120 mg/kg. Mucocutaneous side-effects occur frequently but are manageable while severe systemic side-effects are rarely problematic (2%). The teratogenicity of oral isotretinoin demands responsible consideration by both female patients and their physicians. Significant cost savings when treating acne patients with oral isotretinoin as compared to other treatment modalities were further proven in this study. CONCLUSIONS Our recommendation is that oral isotretinoin should be prescribed not only to patients with severe disease but also to patients with less severe acne, especially if there is scarring and significant psychological stress associated with their disease. Acne patients should, where appropriate, be prescribed isotretinoin sooner rather than later.
Is Parkinson's disease a prion disorder?

In this issue of PNAS, Desplats et al. (1) demonstrate that nerve cells that overexpress tagged α-synuclein can transmit the protein to neural stem cells in both in vitro and in vivo models. This important study could explain the remarkable finding that human embryonic dopamine nerve cells implanted into the striatum of patients with Parkinson's disease (PD) develop PD pathology with loss of dopamine markers and classic Lewy bodies (2, 3). It also provides insight into how α-synuclein pathology might sequentially spread throughout the nervous system in PD.
Running head : HOW SEXUAL IS SEXUAL DESIRE ? ! 1 ! ! ! ! ! How Sexual is Sexual Desire ? Desire and Testosterone in Women

Though research has indicated links between sexual desire and testosterone (T) in women, few studies have considered the possibility that sexual desire may not be entirely ‘sexual’ in all circumstances. In this study, we examined the link between various forms of sexual desire (e.g., desire for orgasm, for emotional connectedness, for stress reduction, etc.) and T in a sample of healthy women. Participants (N = 198), both partnered (n = 83) and single (n = 115), completed the Desire Components Questionnaire (DCQ), a measure we created to address strength of multifaceted components of sexual desire. Participants were randomly assigned to imagine a partner or stranger while answering these questions. We used factor analysis to resolve the 65item questionnaire into 11 subscales, each exhibiting high internal consistency. There was a significant multivariate effect of relationship status and instruction manipulation on desire score. Scores were correlated with T assayed from saliva samples. Desire scores on the Kink/Reproduce subscale were significantly positively correlated with T, with desire to fantasize and desire to act out a fantasy most strongly accounting for the correlation. Findings from the study suggest that sexual desire is not entirely sexual in nature, but instead may reflect desire characterized by other psychosocial factors (e.g., emotional connectedness, sexual context, stress reduction/distraction, etc.). Results are discussed in light of the Steroid/Peptide Theory of Social Bonds, which argues that sexual phenomena can be subdivided into high and low T categories in ways that are partially supported by the present study.
Double-Blind Comparison of Clozapine with Chlorpromazine in Acute Schizophrenic Illness*

Double Blind comparative trial of a new dibenzodiazepine derivative Clozapine (Leponex) with Chlorpromazine was conducted in the treatment of acute schizophrenic illness over a 6 week period. Factor Analysis of ratings in 9 matched pairs indicates that Clozapine, at 300 mg. per day, is comparable in efficacy to Chlorpromazine in all factors except “Irritability” for which Clozapine appears to be superior. Illness severity and Global Change ratings in all patients showed that Clozapine is more effective in producing a shift towards improvement at the end of 6 weeks. Major side effects reported in Clozapine confirmed sedation and hypersalivation as consistent problems and presence of rigidity and tremor (extra-pyramidal) being at variance with other studies.
Cellular immunity to merozoite surface protein 2 (FC27 and 3D7) in Papua New Guinean children. Temporal variation and relation to clinical and parasitological status

A prospective study in 207 children aged 0.5–15 years was carried out in a highly endemic area of Papua New Guinea to examine the relationship between cellular responses to Plasmodium falciparum merozoite surface protein 2 (MSP2) and malaria infection and morbidity. In vitro proliferation, IFN‐γ and IL‐4 induction were measured against two recombinant proteins of MSP2, FC27 and 3D7 as well as against a form of the 3D7 MSP2 lacking the central repetitive sequences (d3D7). The prevalence of proliferative response was generally low, 6% for FC27, 9% for 3D7 and 11% for d3D7. A higher prevalence of IL‐4 response was obtained being 27% for FC27, 34% for 3D7 and 30% for d3D7 while the prevalence of IFN‐γ response was 13%, 15% and 18%, respectively. There was no correlation between age and proliferative responses; in contrast cytokine production increased with age for all three antigens. When proliferation or stimulation of either cytokine was used to assess T‐cell activation the frequency of responders increased to 39%, 47% and 46% for FC27, 3D7 and d3D7 respectively. Analysis of the relation of T cell responses to concurrent infection and morbidity showed that lymphoproliferative response only to d3D7 was significantly associated with parasitaemia; while lymphoproliferative responses to all 3 MSP2 antigens were highest in the group of clinical malaria cases. There was no significant correlation between proliferation or cytokine production to MSP2 and concurrent or subsequent malaria morbidity.
Resolution enhancement of lung 4D-CT via group-sparsity.

PURPOSE 4D-CT typically delivers more accurate information about anatomical structures in the lung, over 3D-CT, due to its ability to capture visual information of the lung motion across different respiratory phases. This helps to better determine the dose during radiation therapy for lung cancer. However, a critical concern with 4D-CT that substantially compromises this advantage is the low superior-inferior resolution due to less number of acquired slices, in order to control the CT radiation dose. To address this limitation, the authors propose an approach to reconstruct missing intermediate slices, so as to improve the superior-inferior resolution. METHODS In this method the authors exploit the observation that sampling information across respiratory phases in 4D-CT can be complimentary due to lung motion. The authors' approach uses this locally complimentary information across phases in a patch-based sparse-representation framework. Moreover, unlike some recent approaches that treat local patches independently, the authors' approach employs the group-sparsity framework that imposes neighborhood and similarity constraints between patches. This helps in mitigating the trade-off between noise robustness and structure preservation, which is an important consideration in resolution enhancement. The authors discuss the regularizing ability of group-sparsity, which helps in reducing the effect of noise and enables better structural localization and enhancement. RESULTS The authors perform extensive experiments on the publicly available DIR-Lab Lung 4D-CT dataset [R. Castillo, E. Castillo, R. Guerra, V. Johnson, T. McPhail, A. Garg, and T. Guerrero, "A framework for evaluation of deformable image registration spatial accuracy using large landmark point sets," Phys. Med. Biol. 54, 1849-1870 (2009)]. First, the authors carry out empirical parametric analysis of some important parameters in their approach. The authors then demonstrate, qualitatively as well as quantitatively, the ability of their approach to achieve more accurate and better localized results over bicubic interpolation as well as a related state-of-the-art approach. The authors also show results on some datasets with tumor, to further emphasize the clinical importance of their method. CONCLUSIONS The authors have proposed to improve the superior-inferior resolution of 4D-CT by estimating intermediate slices. The authors' approach exploits neighboring constraints in the group-sparsity framework, toward the goal of achieving better localization and noise robustness. The authors' results are encouraging, and positively demonstrate the role of group-sparsity for 4D-CT resolution enhancement.
Racial/ethnic disparities in the identification of children with autism spectrum disorders.

OBJECTIVES We sought to examine racial and ethnic disparities in the recognition of autism spectrum disorders (ASDs). METHODS Within a multisite network, 2568 children aged 8 years were identified as meeting surveillance criteria for ASD through abstraction of evaluation records from multiple sources. Through logistic regression with random effects for site, we estimated the association between race/ethnicity and documented ASD, adjusting for gender, IQ, birthweight, and maternal education. RESULTS Fifty-eight percent of children had a documented autism spectrum disorder. In adjusted analyses, children who were Black (odds ratio [OR] = 0.79; 95% confidence interval [CI] = 0.64, 0.96), Hispanic (OR = 0.76; CI = 0.56, 0.99), or of other race/ethnicity (OR = 0.65; CI = 0.43, 0.97) were less likely than were White children to have a documented ASD. This disparity persisted for Black children, regardless of IQ, and was concentrated for children of other ethnicities when IQ was lower than 70. CONCLUSIONS Significant racial/ethnic disparities exist in the recognition of ASD. For some children in some racial/ethnic groups, the presence of intellectual disability may affect professionals' further assessment of developmental delay. Our findings suggest the need for continued professional education related to the heterogeneity of the presentation of ASD.
A Recipe for Democracy? The Spread of the European Diet and Political Change

This paper reveals the relationship between the improvement in human diet and the transition to democracy. The spread of a ‘European diet’ with a historically unprecedented high proportion of animal protein in the daily calorie intake is considered one of the factors of regime change since 1992. In contrast to other studies, I regard European diet as an outcome of a long historical transformation and show that an improvement in nutrition preceded regime change. Data on nutrient consumption around the world are from the Food balance sheet data from FAOSTAT. Based on this data I was able to define a European diet as containing animal-protein rich items (mostly, meat and dairy), alcohol beverages and sugar. Using OLS, factor analysis and SEM, the direct and indirect effects of the European diet on the chance of a transition to democracy were tested. The findings reveal that an improvement in diet affects regime change, but not vice versa
Screening Questionnaires for Problem Drinking in Adolescents: Performance of AUDIT, AUDIT-C, CRAFFT and POSIT

Background/Aims: Only rather few data on the validity of screening questionnaires to detect problem drinking in adolescents exist. The aim of this study was to compare the performance of the Alcohol Use Disorders Identification Test (AUDIT), its short form AUDIT-C, the Substance Module of the Problem Oriented Screening Instrument for Teenagers (POSIT), and CRAFFT (acronym for car, relax, alone, forget, family, and friends). Methods: The questionnaires were filled in by 9th and 10th graders from two comprehensive schools. All students received an interview using the alcohol section of the Composite International Diagnostic Interview. Alcohol abuse and alcohol dependence according to DSM-IV as well as episodic heavy drinking served as criteria to validate the screening instruments. Results: All 9th and 10th graders (n = 225) of both schools participated. No significant differences were found for areas under the receiver operating characteristic curves ranging from 0.810 to 0.872. Cronbach’s alpha was satisfactory (0.77–0.80) but poor for CRAFFT (0.64). Different cut-offs are discussed. Conclusions: Considering validity as well as reliability, AUDIT, AUDIT-C and POSIT performed well; however, the POSIT is quite lengthy. AUDIT-C showed good psychometric properties and has clear advantages because of its brevity.
Biplanar MRI for the assessment of the spinal cord in multiple sclerosis

Objective: To investigate the entire spinal cord (SC) of multiple sclerosis (MS) patients with biplanar MRI and to relate these MRI findings to clinical functional scores. Methods: Two hundred and two patients (140 women, 62 men 24–74 years, Expanded Disability Status Scale (EDSS) scores 0–7.5) were investigated clinically and with biplanar MRI. Sagittal and axial proton density weighted (PDw) and T2 weighted (T2w) images of the whole SC were obtained employing parallel imaging. Data were analyzed by consensus reading using a standardized reporting scheme. Different combinations of findings were compared to EDSS scores with Spearman’s rank correlation coefficient (ρ). Results: The combined analysis of sagittal and axial planes demonstrated slightly differing results in 97/202 (48%) patients. There were 9% additional lesions identified, leading to a higher lesion count in 28% of these patients, but also rejection of equivocal abnormality leading to a lower lesion count in 11% of patients. Considering both sagittal and axial images, SC abnormalities were found in 167/202 (83%) patients. When compared with EDSS scores, the combination of focal lesions, signs of atrophy and diffuse abnormalities showed a moderate correlation (ρ=0.52), that precludes its use for individual patient assessment. Conclusion: Biplanar MRI facilitates a comprehensive identification, localization, and grading of pathological SC findings in MS patients. This improves the confidence and utility of SC imaging.
User communication behavior in mobile communication software

Purpose The purpose of this paper is to develop a research model examining users’ perceived needs-technology fit of mobile communication software through motivational needs and technological characteristics. The study investigated the effects of perceived needs-technology fit on user satisfaction and intention to continue using mobile communication software. Design/methodology/approach This study proposes a research model based on task-technology fit theory and uses and gratification theory, incorporating key determinants of users’ continuance intention toward mobile communication software. An online survey instrument was developed to collect data, and 403 questionnaires were used to test the relationships in the proposed model. Findings The causal model was validated using AMOS 21.0, and all nine study hypotheses were supported. The results indicated that users’ perceived needs-technology fit and satisfaction were crucial antecedents of their intention to continue using mobile communication software and that they mediated the influence of users’ needs as well as technological characteristics. Practical implications Mobile communication software practitioners should focus on enhancing users’ perceived needs-technology fit through motivational needs (utilitarian, hedonic, and social needs) and technological characteristics (mobile convenience, service compatibility, and user control) to further boost user satisfaction and intention to continue using mobile communication software services. Originality/value This study contributes to a theoretical understanding of factors explaining users’ continuance intention toward mobile communication software.
A case of an infant with congenital combined pituitary hormone deficiency and normalized liver histology of infantile cholestasis after hormone replacement therapy

Abstract. Congenital combined pituitary hormone deficiency (CPHD) may present with cholestasis in the neonate or during early infancy. However, its precise mechanism is unknown. A 3-mo-old boy presented with cryptorchidism and hypoplastic scrotum after birth. Neonatal jaundice was noted but temporarily improved with phototherapy. Jaundice recurred at 2 mo of age. Elevated direct bilirubin (D-Bil) and liver dysfunction were found but cholangiography showed no signs of biliary atresia (BA). Liver biopsy findings showed giant cell formation of hepatocytes with hypoplastic bile ducts. Subsequent magnetic resonance imaging (MRI) of the head revealed a hypoplastic pituitary gland with an ectopic posterior lobe, and the patient was diagnosed with congenital CPHD based on decreased secretion of cortisol and GH by the pituitary anterior lobe load test. D-Bil levels promptly improved after hydrocortisone (HDC) replacement. We subsequently began replacement with levothyroxine (L-T4) and GH, and liver histology showed normal interlobular bile ducts at 8 mo old. This is the first case report of proven histological improvement after hormone replacement therapy. This suggested that pituitary-mediated hormones, especially cortisol, might be involved in the development of the bile ducts.