Miracle-dz/UniFAR-FTUs huggingface dataset:
Family accommodation in obsessive–compulsive disorder

Family accommodation refers to ways in which family members take part in the performance of rituals, avoidance of anxiety-provoking situations or modification of daily routines to assist a relative with obsessive–compulsive disorder (OCD). Our goal is to review the available data on the role of family accommodation in both children and adults with OCD. A search of available peer-reviewed English language papers was conducted through PubMed and PsycINFO cross-referencing the keyword OCD with accommodation, family relations and parents. The resulting 641 papers were individually evaluated for relevance to the scope of the review. It was found that accommodation is common in OCD and is strongly and consistently correlated with OCD symptom severity. Family accommodation also appears to be increased when the proband has cleaning contamination symptoms and increased internalizing or externalizing problems. Family accommodation is associated with increased parental OCD and anxiety symptoms. Levels of accommodation are associated with treatment outcomes for both behavioral and pharmacological treatment. Significant improvement of OCD symptoms with treatment is associated with reductions in family accommodation. Family accommodation represents important clinical data that is worth measuring, monitoring and tracking in clinical care. Therapies targeting family accommodation may be successful in improving treatment outcomes in OCD.
Cryopreservation of the infective larvae of the common nematodes of ruminants.

Exsheathed infective larvae (L 3) of 19 species of nematodes were tested for infectivity in either sheep or cattle after they had been frozen in 0,9% NaCl solution, stored for a relatively short time in the gas phase of liquid nitrogen and subsequently thawed. In addition, 13 of these species were tested after similar storage for up to 18 months. In sheep, Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, Trichostrongylus colubriformis, Nematodirus spathiger and Oesophagostomum columbianum were viable after 2 years of cryopreservation, a mean of greater than 90% of the L 3 being alive when thawed after this period. Similar results were obtained with Chabertia ovina L 3 after 18 months and with Marshallagia marshalli, Trichostrongylus falculatus and Dictyocaulus filaria, after a short period of freezing. On the other hand, Gaigeria pachyscelis and Strongyloides papillosus survived freezing for up to 7 months but neither was viable at the end of this period, nor was exsheathed G. pachyscelis viable without freezing. Most of these infestations were established by inoculating the infective larvae into the abomasum and/or duodenum. M. marshalli, T. falculatus and C. ovina also proved infective after oral dosing. D. filaria, the only other species tested by this route, was not infective when dosed per os after thawing. The infective larvae of the bovine nematodes, Haemonchus placei, Ostertagia ostertagi, Nematodirus helvetianus, Oesophagostomum radiatum, Cooperia pectinata and Cooperia punctata survived freezing for a mean of 26 months, greater than 90% being alive on thawing, but infectivity was generally lower than with the same genera in sheep. Even when not frozen, exsheathed Bunostomum phlebotomum was non-infective. When Cooperia spp. after thawing were tested for infectivity by the oral route, more worms developed in one calf infested orally than in another infested by inoculation into the duodenum. Ova of H. contortus, M. marshalli, O. circumcincta, T. colubriformis, T. falculatus, N. spathiger, C. ovina, H. placei, O. ostertagi, Cooperia spp. and N. helvetianus were recovered from the faeces of animals infested with cryopreserved L 3. No ova of O. columbianum or O. radiatum were recovered from faeces, because differential larval counts were performed before they were patent. Nevertheless, gravid females were obtained post-mortem. Frozen L 3 of N. helvetianus were used to re-establish a pure strain in calves, 2,3 million ova being recovered from infestations with 10 670 L 3 frozen for 26 months. The infectivity of the progeny of frozen L 3 was tested with M. marshalli and C. ovina. In both instances infectivity was high and the worms which developed also produced ova, thus completing the cycle. This appears to be the first report of infective larvae of parasitic nematodes retaining their infectivity after being frozen in liquid nitrogen (gas phase) for longer than 2 years. This is also apparently the first time that M. marshalli T. colubriformis, T. falculatus, T. axei, N. spathiger, C.
Sex Differences in Cognition: The Role of Testosterone and Sexual Orientation

The performance of both heterosexual and homosexual males and females was compared on four cognitive tasks which have been shown to reveal evidence of sexual dimorphism. In one spatial and one verbal task, significant sex and orientation effects were found. Significant relationships were also found between salivary free-testosterone levels and performance on both spatial tasks, but no significant associations were found for performance on the two verbal tasks. The present study revealed both within- and between-sex differences in cognition and indicates that these differences may be partly accounted for by the activational effects of free testosterone.
MOS interface engineering for high-mobility Ge CMOS

In this paper, we have discussed the fundamental properties of the germanium oxides formed by thermal oxidation and plasma post-oxidation as interfacial layers for Ge MOSFETs. The germanium oxides form high-quality Ge MOS interface with interface trap density of around 1011 cm-2eV-1. High-mobility Ge n-MOSFETs and p-MOSFETs have successfully been demonstrated even with EOT of less than 0.8 nm, exhibiting that the germanium oxides are the most promising interfacial layers for future Ge CMOS.
Low-frequency loud acoustic stimulation and goal-directed arm movements

Objective To analyse the effects of low-frequency loud acoustic stimulation on goal-directed movements involving the arm. Low-frequency sound stimulation impairs eye stability, evokes a subjective tilt of the visual surround in subjects presenting Tullio's phenomenon and induces, in normal subjects, short-latency evoked potentials in the neck and limb muscles. Material and Methods Healthy subjects performed goal-directed movements in the horizontal plane with the right (dominant) arm to a fixed 3°-wide target positioned at an angle of 30°, with the instruction to perform fast and accurate movements to the target and to hold the final position. This fast-pointing task was performed in association with sound-induced vestibular–otolithic stimulation (110 dB SPL, 500 Hz) in the absence of visual guidance (i.e. pointing at a memorized target in the absence of target or pointer cues). Pointing errors were analysed by computing the constant errors made by the subjects (mean error). Pointing errors were also correlated with movement kinematics (movement duration, peak velocity, time to peak velocity) and with the reaction time of movement. Results The low-frequency loud acoustic stimulation modified the final position of the arm-pointing task at the memorized target in the absence of vision. Conclusion Goal-directed movements are achieved by means of sensory interactions between visual, somatosensory and vestibular information and the vestibular–otolithic signals contribute to the accuracy of voluntary arm movements.
Long-Term Follow-up of Arthrodesis vs Total Joint Arthroplasty for Hallux Rigidus

Background: The optimal operative management of hallux rigidus is still a matter for debate among surgeons. Despite arthrodesis widely considered to be the gold standard treatment, many surgeons advocate arthroplasty as a suitable alternative. There are, however, few long-term or high-quality studies evaluating these modalities. We present the 15-year follow-up of a randomized controlled trial. Methods: This data is the follow-up to the original study published in 2005. In the original study, 63 patients (77 toes) were recruited to and randomized to have either metatarsophalangeal joint (MTPJ) arthrodesis or arthroplasty. The primary outcome measure was a decrease in pain on a visual analog scale (VAS) at 24 months. In the present study, data were available for all surviving patients (52 patients, 66 toes). Data were collected in the form of satisfaction scores, VAS for pain, the VAS foot and ankle and survivorship data. Results: The results of the original study demonstrated that pain relief was greater following arthrodesis at 2 years. At 15 years, patients with an arthrodesis experienced less pain and were more satisfied compared to those with an arthroplasty. No functional differences were seen between these 2 groups. There were more revisions in the arthroplasty group. Conclusion: Despite the hope of better function, less pain, and greater satisfaction from MTPJ replacement, this was not found in our patient population. The long-term results of our study showed that arthrodesis outperformed arthroplasty. If an arthroplasty failed, then salvage was likely to be technically difficult, with significant potential for complications. Level of Evidence: Level I, randomized controlled trial.
Toxicological evaluation of the plant products using Brine Shrimp (Artemia salina L.) model

Many natural products could serve as the starting point in the development of modern medicines because of their numerous biological and pharmacological activities. However, some of them are known to carry toxicological properties as well. In order to achieve a safe treatment with plant products, numerous research studies have recently been focused on both pharmacology and toxicity of medicinal plants. Moreover, these studies employed efforts for alternative biological assays. Brine Shrimp Lethality Assay is the most convenient system for monitoring biological activities of various plant species. This method is very useful for preliminary assessment of toxicity of the plant extracts. Rapidness, simplicity and low requirements are several advantages of this assay. However, several conditions need to be completed, especially in the means of standardized experimental conditions (temperature, pH of the medium, salinity, aeration and light). The toxicity of herbal extracts using this assay has been determined in a concentration range of 10, 100 and 1000 μg/ml of the examined herbal extract. Most toxicity studies which use the Brine Shrimp Lethality Assay determine the toxicity after 24 hours of exposure to the tested sample. The median lethal concentration (LC50) of the test samples is obtained by a plot of percentage of the dead shrimps against the logarithm of the sample concentration. LC50 values are estimated using a probit regression analysis and compared with either Meyer’s or Clarkson’s toxicity criteria. Furthermore, the positive correlation between Meyer’s toxicity scale for Artemia salina and Gosselin, Smith and Hodge’s toxicity scale for higher animal models confirmed that the Brine Shrimp Lethality Assay is an excellent predictive tool for the toxic potential of plant extracts in humans.
Immunocytochemical Detection of Estrogen Receptor-α in the Female Rabbit Forebrain: Topography and Regulation by Estradiol

Two antibodies (H222 and Zymed) directed towards different sites of the estrogen receptor-α (ERα) were used for the following objectives: (1) to map the ERα in the forebrain of ovariectomized (ovx) rabbits by immunocytochemistry and (2) to determine the effect of endogenous (intact non-pregnant animals) and exogenous (ovx, estrogen-treated animals) estradiol (E2) on the population of ERα in the forebrain. Similar results were obtained with both antibodies used: dense aggregations of ERα-immunoreactive (IR) neurons were found in the infundibular nucleus (IN), the medial preoptic area (POA), the bed nucleus of the stria terminalis (BNST), and some nuclei of the amygdala. By contrast, no ERα-IR neurons were present in the ventromedial hypothalamic nucleus (VMN), but a dense aggregation of ERα-IR neurons occurred lateral to it in nucleus X. Numerous ERα-IR neurons were observed in the paraventricular hypothalamic nucleus, but not in the supraoptic or suprachiasmatic nuclei. The hippocampus proper lacked ERα-IR neurons, but the ventral subiculum in the hippocampal formation had a dense group of such cells. Intact non-pregnant rabbits showed less ERα-IR neurons in all regions tested than ovx animals. This difference was particularly clear in the medial POA, amygdala and BNST, while the IN showed only a marginal decrease. The dorsal, but much less the ventral, part of nucleus X also showed a decrease in the number of ERα-IR neurons compared with ovx animals. E2 benzoate (5 µg/day for 5 days) reduced even further the number of ERα-IR neurons in all regions except in a circumscribed area of the IN and the ventral part of nucleus X. These results show the existence of both sensitive and insensitive neurons to the down-regulatory effect of E2 on the presence of ERα. Sensitive neurons are located in the telencephalon, POA and several hypothalamic nuclei (PVN), while insensitive neurons are mainly restricted to the IN and the ventral part of nucleus X in the basal hypothalamus.
A STIMULUS CONTROL PROCEDURE TO DECREASE MOTOR AND VOCAL STEREOTYPY

A changing criterion design was used to examine the effects of two stimuli (a green card and a red card), conditioned via discrimination training, on reducing motor and vocal stereotypy in a youngster with autism while he looked at books. During discrimination training, motor and vocal stereotypy was not interrupted in the presence of a green stimulus, but was interrupted in the presence of a red stimulus using manual guidance and appropriate behavior was reinforced. After the participant demonstrated successful discrimination of the stimuli (i.e., the absence of stereotypy in the presence of a red stimulus and the engagement in stereotypy in the presence of a green stimulus), intervention began. During intervention, upon meeting criterion for latency to engage in motor and vocal stereotypy in the presence of the red stimulus for a target duration, the participant was provided access to the green stimulus, which signaled that motor and vocal stereotypy would not be interrupted. The criterion latency to engage in stereotypy in the presence of the red stimulus was systematically increased. Simultaneously, the duration of access to the green stimulus was systematically decreased. The red and green stimuli were faded from poster boards to colored 10 × 10 cm cards, and stimulus control was generalized to the participant's classroom and to a community setting (i.e., public library). Results are discussed in terms of discrimination training as a useful intervention for reducing motor and vocal stereotypy. Copyright © 2011 John Wiley & Sons, Ltd.
A binary whale optimization algorithm with hyperbolic tangent fitness function for feature selection

To overcome the curse of dimensionality problem, a binary variant of the whale optimization algorithm (bWOA) with V-shaped is proposed. A hyperbolic tangent function is employed as a fitness function for mapping the continuous values to binary ones. Feature selection (FS) has attracted much attention in recent years and played a critical role in dealing with high-dimensional problems and can be modeled as an optimization problem. Eleven datasets from UCI repository from various applications are used. During the experiments, the effectiveness of feature selection is tested via a different type of data and size of features in the generic dataset. Furthermore, Wilcoxons rank-sum nonparametric statistical test was carried out at 5% significance level to judge whether the results of the proposed algorithms differ from those of the other compared algorithms in a statistically significant way. The quantitative and qualitative results revealed that the proposed binary algorithm in the FS domain is capable of minimizing the number of selected features as well as maximizing the classification accuracy within an appropriate time.
Managing pregnancy-related nocturnal nasal congestion. The external nasal dilator.

OBJECTIVE To assess the efficacy of an over-the-counter mechanical nasal dilator during sleep in pregnant women with nasal congestion. STUDY DESIGN Pregnant women with symptoms of nocturnal nasal congestion not attributed to allergies or "cold" symptoms were randomized in a double-blind manner to receive either a spring-loaded device or placebo device without a spring. Each patient assessed breathing and sleep quality for a three-day baseline and three-day treatment period. A 10-question diary was utilized to assess breathing, ease of falling asleep, sleep quality, and continuity and depth of sleep. Averaged scores for each question were computed for baseline and treatment periods, and differences were calculated. Statistical analyses were by the sign test, Fisher's exact test and Student's test. RESULTS Thirty-four (21%) of 160 screened patients were enrolled into the study; 24 (15%) completed the study. All agreed to being assigned to receive either the spring-loaded device (n = 12) or a placebo (n = 12) device. Responses to 8 of the 10 questions favored the former as compared with the placebo (P = .05, sign test). Moreover, patients treated with the spring-loaded device gave more favorable responses to the question, "Overall, compared with most nights, how easy was your breathing through-out last night? " (P = .02, t test). CONCLUSION Use of this drug-free external nasal dilator improved the ease of breathing among patients with pregnancy-related nocturnal congestion.
Infection of Rice Plants by Rice Black Streaked Dwarf Virus Improves an Egg Parasitoid, Anagrus nilaparvatae (Hymenoptera: Mymaridae), of Rice Planthoppers

ABSTRACT The effects of rice plants infected by rice black streaked dwarf virus (RBSDV) on the host preference, duration of immature stages, sex ratio, and adult longevity and parasitic capacity of an egg parasitoid, Anagrus nilaparvatae Pang et Wang, of rice brown planthopper, Nilaparvata lugens Stål, were evaluated. Tests of response to plant volatiles using an olfactometer showed that A. nilaparvatae preferred rice plants harboring rice brown planthopper eggs over plants free of rice brown planthopper eggs. However, both the response to plant volatiles and the host selectivity test showed no significant differences in host preference between RBSDV-infected plants and healthy plants when both contained rice brown planthopper eggs. The developmental duration at immature stage of the male A. nilaparvatae in rice brown planthopper eggs on RBSDV-infected rice plants was significantly prolonged, and the parasitic capacity of rice brown planthopper eggs was significantly increased in comparison with the A. nilaparvatae parasite in rice brown planthopper eggs on healthy rice plants. There were no significant differences between RBSDV-infected rice plants and healthy rice plants in other ecological fitness parameters, including the developmental duration of female adults, female percentage, and adult longevity of A. nilaparvatae.
Cuff and pouch cancer in patients with inflammatory bowel disease: what surveillance strategy should be recommended?

To the Editor: With great interest, we read the systematic review by Selvaggi et al regarding cuff and pouch cancer in patients with ulcerative colitis (UC). Using clear study selection criteria, the authors evaluated epidemiology and risk factors of pouch-related malignancies after ileal pouch-anal anastomosis (IPAA) for UC. Main findings were a low pooled cumulative incidence of pouch and cuff cancer (0.35%, 20 yr after IPAA) and the identification of prior colorectal neoplasia as the predominant risk factor (odds ratio, 8.8) for developing pouch-related carcinoma. The authors then propose an endoscopic surveillance strategy of the pouch but based on our interpretation of the data, we suggest an alternative approach. First, the authors recommended routine surveillance pouchoscopy starting 10 years after UC diagnosis followed by annual surveillance. However, the risk of pouch-related cancer is low and should be placed in perspective. For example, cumulative colorectal cancer risk from birth to 75 years is 1.96% in the general population, compared with a defined pooled cumulative incidence of pouchrelated malignancies of 0.33% for 50 years after UC diagnosis and 0.35% for 20 years after IPAA. The early starting point and subsequent high surveillance frequency as recommended is at odds with the low risk. Second, the authors suggest a delayed surveillance strategy in patients who underwent mucosectomy. This proposed risk stratification for pouch surveillance does not take into account the single most important risk factor, neoplasia of the colectomy specimen. In our opinion, patients with prior colorectal neoplasia do require an intensified pouch surveillance program. Third, no surveillance strategy was proposed for patients with Crohn’s disease or indeterminate colitis because these subgroups were excluded from analyses. We advocate a pouch surveillance program for all patients with inflammatory bowel disease. Crohn’s disease and indeterminate colitis patients do carry a pouchrelated cancer risk, and no evidence is available to support a separate surveillance strategy. We applaud the efforts by Selvaggi et al because this will contribute toward the development of evidence-based pouch surveillance programs. By contrast, we favor a limited pouch surveillance program for all patients with inflammatory bowel disease with IPAA given the low pouch-related carcinoma incidence. Patients with prior colorectal neoplasia should be subjected to a more intensified pouch surveillance strategy with special attention for the anal transitional zone where most carcinomas are localized. Whether pouch surveillance prevents pouch and cuff cancer or improves clinical outcomes remains an area of future research.
[Can patient satisfaction change over time?].

INTRODUCTION Though use of repeated generic measurements of patient satisfaction is increasing, we have limited knowledge of how results change over time. The present study focused on systematic changes of inpatients' satisfaction both at high and low organizational levels, and addressed the question of whether there is an association to occupancy rates, acute rates and local leaders' evaluation of the concept for monitoring patient satisfaction. MATERIAL AND METHODS During the period from 1999 to 2006, the County of Aarhus carried out detailed patient satisfaction surveys over four periods in eight somatic hospitals. The 71 wards participating in the first three periods were included. Organizational data were drawn from a management information system. A questionnaire to heads of department and hospital was used to evaluate the concept after each period. RESULTS At county level there was no significant development in satisfaction during the period. However, the wards with the lowest evaluations from the first round experienced significant and persisting improvements over the next two periods. The wards which experienced significant improvements were characterised by having few acute patients. CONCLUSION The study shows that patient satisfaction can change over time. There seems to be a positive effect associated with first time measurements on a detailed organizational level. Persistent improvements of patient satisfaction were seen on the wards with lowest satisfaction at baseline, indicating that the concept seems to have a positive impact on performance. Wards with a high acute rate seem to have difficulties in improving patient satisfaction.