Miracle-dz/UniFAR-FTUs huggingface dataset:
Iris Image Blur Detection with Multiple Kernel Learning

In this letter, we analyze the influence of motion and outof-focus blur on both frequency spectrum and cepstrum of an iris image. Based on their characteristics, we define two new discriminative blur features represented by Energy Spectral Density Distribution (ESDD) and Singular Cepstrum Histogram (SCH). To merge the two features for blur detection, a merging kernel which is a linear combination of two kernels is proposed when employing Support Vector Machine. Extensive experiments demonstrate the validity of our method by showing the improved blur detection performance on both synthetic and real datasets. key words: frequency spectrum, cepstrum, multiple kernel learning
STUDY OF THE INFECT ORGANIZATIONAL CULTURE AND JOB SATISFACTION. (IN SCIENTIFIC RESEARCH CENTER AFFILIATED TO THE MINISTRY OF SCIENCE, RESEARCH, AND TECHNOLOGY IN TEHRAN)

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Enterococcus faecalis Virulence Regulator FsrA Binding to Target Promoters

ABSTRACT The FsrABDC signal transduction system is a major virulence regulator in Enterococcus faecalis. The FsrC sensor histidine kinase, upon activation by the gelatinase biosynthesis-activating pheromone (GBAP) peptide encoded by the fsrBD genes, phosphorylates the FsrA response regulator required for the transcription of the fsrBDC and the gelE-sprE genes from the fsrB promoter and the gelE promoter, respectively. FsrA belongs to the LytTR family of proteins, which includes other virulence regulators, such as AgrA of Staphylococcus aureus, AlgR of Pseudomonas aeruginosa, and VirR of Clostridium perfringens. The LytTR DNA-binding domain that characterizes these proteins generally binds to two imperfect direct repeats separated by a number of bases that place the repeats on the same face of the DNA helix. In this study, we demonstrated that FsrA also binds to two imperfect direct repeats separated by 13 bp, based on the consensus sequence of FsrA, T/AT/CAA/GGGAA/G, which is consistent with the binding characteristics of LytTR domains.
Long-term evaluation of postmastectomy breast reconstruction with the pedicled transverse rectus abdominis musculocutaneous flap

Abstract The transverse rectus abdominis musculocutaneus (TRAM) flap is ideal for unilateral breast reconstruction. It can produce a breast with a lasting natural look, soft feeling, and good resemblance to the opposite breast. The aim was to evaluate long-term results of the TRAM flap reconstruction in an homogenous study population and to examine the impact on abdominal competence, appearance, and function relative to patient satisfaction. The study included 123 women from the cohort of patients undergoing a postmastectomy breast reconstruction in the period from 1992–2005. Data was collected from patient charts, a study-specific questionnaire, and a clinical follow-up visit. The response to the questionnaire was 81% (100/123), and 78 of them participated in a clinical follow-up visit. Eighty-four per cent were satisfied with the overall results of their breast reconstruction, and the majority of the women were pleased with the overall appearance of their abdomen. A significant correlation existed between satisfaction with the abdominal appearance and donor site complications (p = 0.01). No association was determined between complications in the breast area and smoking. A BMI above 25 increased the risk of complications. Radiation therapy (RT) significantly increased the risk of severe complications (p = 0.04) and of an inferior aesthetic result (p = 0.03). In conclusion, after a median of 6 years, women reconstructed with a TRAM flap were pleased with the overall result, with the appearance and strength of their abdomen including the umbilicus. Breast reconstruction with the pedicled TRAM flap results in lasting good results and pleased patients.
Numerical studies of shear banding in interface shear tests using a new strain calculation method

Strain localization is closely associated with the stress–strain behaviour of an interphase system subject to quasi‐static direct interface shear, especially after peak stress state is reached. This behaviour is important because it is closely related to deformations experienced by geotechnical composite structures. This paper presents a study using two‐dimensional discrete element method (DEM) simulations on the strain localization of an idealized interphase system composed of densely packed spherical particles in contact with rough manufactured surfaces. The manufactured surface is made up of regular or irregular triangular asperities with varying slopes. A new simple method of strain calculation is used in this study to generate strain field inside a simulated direct interface shear box. This method accounts for particle rotation and captures strain localization features at high resolution. Results show that strain localization begins with the onset of non‐linear stress–strain behaviour. A distinct but discontinuous shear band emerges above the rough surface just before the peak stress state, which becomes more expansive and coherent with post‐peak strain softening. It is found that the shear bands developed by surfaces with smaller roughness are much thinner than those developed by surfaces with greater roughness. The maximum thickness of the intense shear zone is observed to be about 8–10 median particle diameters. The shear band orientations, which are mainly dominated by the rough boundary surface, are parallel with the zero extension direction, which are horizontally oriented. Published in 2007 by John Wiley & Sons, Ltd.
An update on safety studies of SAD B19 rabies virus vaccine in target and non-target species

SAD B19 is an attenuated vaccine virus for oral vaccination of carnivores against rabies. The safety of SAD B19 was investigated in 16 animal species by different routes of administration. During the observation period all animals given the vaccine virus, irrespective of the route of administration, did not show any clinical signs of rabies, with the exception of certain rodent species. In these animals a low residual pathogenicity was observed, however transmission of the vaccine virus to control animals was not demonstrable. No vaccine virus could be detected in the saliva of the six mammal species examined. Furthermore, the genetical stability was shown for SAD B19 through passaging in neural tissue of dogs, foxes and mice. From the results presented here on innocuity and stability, it can be concluded that SAD B19 rabies vaccine is suitable for oral vaccination campaigns for carnivores against rabies.
Long‐Term Comparison of Tacrolimus‐ and Cyclosporine‐Induced Nephrotoxicity in Pediatric Heart‐Transplant Recipients

Nephrotoxicity is an adverse effect of cyclosporine and tacrolimus. Studies comparing their long‐term nephrotoxicities are lacking. This study evaluates the nephrotoxicity of these agents over a 7‐year period following heart transplantation. Pediatric heart‐transplant recipients receiving cyclosporine or tacrolimus as primary immunosuppression were evaluated at two centers from 1982 to 1998. Data collected included serum creatinine, height and weight prior to transplantation, at 1 and 6 months and 1 years post transplantation, and at yearly intervals thereafter. Creatinine clearance was calculated and compared between the two groups. Glomerular filtration rate was measured using Tc‐99 m diethylenetriaminepentacetic acid. In total, 123 patients were evaluated. Demographic data of the two groups were comparable. Creatinine clearance demonstrated a steady decline. This decline did not differ statistically between the two groups: tacrolimus 98.9 and 90.7 mL/min/1.73 m2 at 1 month and 5 years, respectively; cyclosporine 110.7 and 81.7 mL/min/1.73 m2 at 1 month and 5 years, respectively. Four patients developed end‐stage renal failure. Calculated creatinine clearance consistently overestimated glomerular filtration rate, the latter being greater than 2 standard deviations below the mean normal in 38% of patients. We conclude that the nephrotoxicities of tacrolimus and cyclosporine are comparable over the medium‐ to long‐term in pediatric heart‐transplant recipients.
The liver hemopoietic environment: I. Developing hepatocytes and their role in fetal hemopoiesis

Mouse fetal liver was studied ultrastructurally to identify and charaterize the developing hepatic parenchyma or prehepatocyte which may be responsible for producing the liver hemopoietic enviroment. It was observed that as the liver develops, there is close association of endodermal and mesenchymal cells in the region of the septum transversum. Numerous intercellular adhesions were observed between endodermal cells and mesenchymal cells. Twenty‐fours after endodermal and mesenchymal cells first intermingle, the liver extravascular space consisted of consisted of spherical hemopoietic cells dispersed among a heterogenous population of dark and light cells. The reticulum of prehepatocytes formed a three‐demensional cellular network which structurally supported the hemopoietic cells residing in the liver. By 12 days of gestation, prehepatocytes were a homogenous population of dark, stellate cells joined together by numerous intercellular adhesions. Broad areas of intercellular association were noted between processes and prehepatocytes and hemopoietic cells; however, no inercellular junctions between these two disparate cell populations were observed at this or any stage in development. Characteristics reflecting a cell population capable of synthesis and secretion of proteinaceous substances, namely, dilated Golgi apparati, increased numbers of polyribsomes and profiles of rough endoplasmic reticulum (RER), two types of vacuoles and/or vesicles, and intercellular microvillus‐lined spaces, were observed in the prehepatocytes between 12 and 17 days gestation. By day 17 of gestation, glycogen accumulation, biliary channel development, appearance of a subendothelial microvillus surface, nuclear shape and chromatin pattern, and arrangement of cytoplasmic organelles reflected the maturation of prehepatocytes into hepatocytes, the adult liver parenchyma.
Sleep is associated with the metabolic syndrome in a multi-ethnic cohort of midlife women: the SWAN Sleep Study.

STUDY OBJECTIVES We evaluated associations among subjective and objective measures of sleep and the metabolic syndrome in a multi-ethnic sample of midlife women. DESIGN Cross-sectional study. SETTING Participants' homes. PARTICIPANTS Caucasian (n = 158), African American (n = 125), and Chinese women (n = 57); mean age = 51 years. Age range = 46-57 years. INTERVENTIONS None. MEASUREMENTS AND RESULTS Metabolic syndrome was measured in the clinic and sleep quality was assessed by self-report. Indices of sleep duration, continuity/fragmentation, depth, and sleep disordered breathing were assessed by in-home polysomnography (PSG). Covariates included sociodemographics, menopausal status, use of medications that affect sleep, and self-reported health complaints and health behaviors known to influence metabolic syndrome risk. Logistic regression was used to test the hypothesis that the metabolic syndrome would be associated with increased subjective sleep complaints and PSG-assessed sleep disturbances. In univariate analyses, the metabolic syndrome was associated with decreased sleep duration and efficiency and increased NREM beta power and apnea-hypopnea index (AHI). After covariate adjustment, sleep efficiency (odds ratio [OR] = 2.06, 95% confidence interval [CI]: 1.08-3.93), NREM beta power (OR = 2.09, 95% CI: 1.09-3.98), and AHI (OR = 1.86, 95% CI: 1.40-2.48) remained significantly associated with the metabolic syndrome (odds ratio values are expressed in standard deviation units). These relationships did not differ by race. CONCLUSIONS Objective indices of sleep continuity, depth, and sleep disordered breathing are significant correlates of the metabolic syndrome in midlife women, independent of race, menopausal status and other factors that might otherwise account for these relationships.
Comparison of uptake of breast screening, cervical screening, and childhood immunisation

The national breast screening programme invites women aged 50–64 to have mammography every three years, by using the lists of the family health services authorities and health boards to provide a call and recall system. Breast screening centres ask general practitioners to check previous notification lists, encourage attendance, provide practical advice, allay fears, and, with non-attenders, discuss breast screening. Despite the additional workload that promoting a high uptake entails no financial incentive is paid to general practitioners. Cervical screening and childhood immunisation are largely managed and delivered by general practitioners and primary care teams, although some practices also use a central call and recall system. General practitioners receive target payments (payments for reaching certain levels of uptake) for cervical screening and childhood immunisation.1 Different methods of management and remuneration may influence …
Plasma levels of zidovudine twice daily compared with three times daily in six HIV-1-infected children.

OBJECTIVES Zidovudine is often administered every 12 h in HIV-infected children, but so far no pharmacokinetic data are available for the administration of this agent every 12 h. We have evaluated the plasma pharmacokinetics of zidovudine administered every 8 h versus every 12 h in HIV-1-infected children. METHODS In HIV-1-infected children who switched from zidovudine every 8 h to every 12 h, a pharmacokinetic curve was recorded both before and after the switch. Zidovudine plasma levels were measured by HPLC. Pharmacokinetic parameters were calculated by non-compartmental methods. RESULTS Six HIV-1-infected children [median age (range) 7.8 (2.5-13.4) years] were included. In these patients, geometric mean ratios of AUC(0-24) and C(max) for zidovudine every 12 h versus every 8 h were not significantly different from 1.0. CONCLUSIONS The plasma pharmacokinetic parameters of zidovudine taken every 8 h and every 12 h were not significantly different and therefore suggest bioequivalence of these two dose frequencies.
Identification of bacterial diversity in the oyster Crassostrea gigas by fluorescent in situ hybridization and polymerase chain reaction

Aims: To carry out a rapid and reliable identification of bacterial diversity in the oyster Crassostrea gigas from Todos Santos Bay, México, in the current study we applied the molecular techniques of fluorescent in situ hybridization (FISH) and polymerase chain reaction (PCR). In order to reach this goal, genus and group‐specific oligonucleotides targeted to 16S rDNA/rRNA were used.
Antimicrobial and cytotoxic activity of red propolis: an alert for its safe use

Red propolis is a resinous product popularly consumed in Brazil as it improves health, and it is considered a nutraceutical. The objective of this study was to test the antimicrobial activity of eight samples of red propolis from Brazil and Cuba to assess the possibility of application of this natural product as an antimicrobial agent, along with a study of its cytotoxic activity against non‐tumor cell lines to evaluate at which concentrations it could be safely used.
The natural history of pediatric-onset IBD-unclassified and prediction of Crohn’s disease reclassification: a 27-year study

Abstract Objectives: A definitive diagnosis of Crohn’s disease (CD) or ulcerative colitis (UC) in patients who were initially diagnosed as inflammatory bowel disease-unclassified (IBDU) remains challenging. Our aims were to describe the natural history of pediatric-onset IBDU patients during prolonged period of follow up and to identify associated predictors for CD reclassification among them. Materials and methods: In this retrospective single center study, out of 723 patients with pediatric onset IBD, we identified 53 patients (7.3%) diagnosed with IBDU at the Schneider Children’s Medical Center of Israel between 1986 and 2013. Potential predictors for CD reclassification including age at diagnosis, gender, clinical manifestations, disease extent and laboratory findings were assessed. Results: The median follow-up was 6.8 (± 6.7) years. Reclassification to CD was observed in 24/53 (45%) of patients. The median interval from diagnosis to CD reclassification was 9.4 years. In 58% of these patients, CD reclassification occurred within 5 years from diagnosis. Multivariate Cox models showed that familial history of CD and hypoalbuminemia at diagnosis were significantly associated with CD reclassification (HR 11.3, p = .02 and HR 5.3, p = .03, respectively). All other assessed clinical, laboratory and endoscopic parameters did not serve as predictors for CD reclassification later on. Conclusions: In our cohort, a substantial high proportion of pediatric onset IBDU patients were later re-diagnosed as CD. Only a family history of CD and hypoalbuminemia could predict reclassification among IBDU patients.
Analysis of Mitotic and Polytene Chromosomes and Photographic Polytene Chromosome Maps in Bactrocera cucurbitae (Diptera: Tephritidae)

ABSTRACT We report here a cytogenetic analysis of the melon fly, Bactrocera Cucurbitae, Coquillett (Diptera: Tephritidae), a species of significant agricultural importance. The mitotic karyotype and detailed photographic maps of the larval salivary gland polytene chromosomes of the species are presented. The mitotic karyotype consists of six pairs of chromosomes including one pair of heteromorphic sex (XX/XY) chromosomes. The heterogametic sex is ascribed to the male. The analysis of polytene chromosomes has shown a total number of five long polytene elements (10 polytene arms) that correspond to the five autosomes. The characteristic features and the most prominent landmarks of each polytene chromosome are presented. The proposed chromosomal homology between B. Cucurbitae and Mediterranean fruit fly, Ceratitis capitata (Wiedemann), was determined by comparing chromosome banding patterns. The detection of heterozygous chromosome inversions in two strains is shown and discussed. The current study provides workable polytene chromosome maps of the species and compares our results with previous reports. We show that these maps can be used for cytogenetic studies in the species and for comparative studies among the tephritid species. They also can support the development of control methods and clarify the taxonomic status of B. cucurbitae.
Complementary laminar terminations of afferents to area 17 originating in area 18 and in the lateral geniculate nucleus in squirrel monkey

The projections from area 18 and the lateral geniculate nucleus onto area 17 of the squirrel monkey (Saimiri) were investigated with retrograde (horseradish peroxidase) and anterograde (tritiated proline) labelling techniques, and the (Fink‐Heimer) silver impregnation method for degenerating axons and their terminals.
Use of the collagen‐binding assay for von Willebrand factor  in the analysis of type 2M von Willebrand disease:  a comparison with the ristocetin cofactor assay

Summary. This study compares the utility of two functional assays for von Willebrand factor (VWF), the ristocetin cofactor assay (VWF:RCo) and the collagen‐binding assay (VWF:CBA). We analysed a group of 32 patients with type 2 von Willebrand disease (VWD) (25 patients with type 2M, six with type 2A and one with type 2B) and 22 normal control subjects. VWF:RCo/VWF antigen (VWF:Ag) ratios and VWF:CBA/VWF:Ag ratios were compared between the patient and control groups. In the six patients with type 2A VWD, both VWF:RCo/VWF:Ag ratios and VWF:CBA/VWF:Ag ratios were discordant (≤ 0·7). In the 25 type 2M VWD patients, the VWF:CBA/VWF:Ag ratios were concordant (> 0·7), but the VWF:RCo/VWF:CBA ratios were discordant (≤ 0·7) (P = 0·001) compared with control subjects. Thus, VWF:RCo/VWF:Ag ratios were discordant in both type 2M and 2A VWD patient groups indicating a functional abnormality. However, VWF:CBA/VWF:Ag ratios were discordant in the type 2A VWD group but not in the type 2M VWD group. Our study showed that VWF:CBA is sensitive to functional variants associated with the loss of high‐molecular‐weight multimers, i.e. type 2A and 2B in VWD, but the assay was unable to discriminate defective platelet‐binding VWD variants with normal multimeric patterns such as type 2M VWD. It was concluded that the VWF:CBA assay should be used in association with rather than as a replacement for the VWF:RCo assay.
The influence of disease and age on human cardiac stem cells

Recent studies have found that cardiac stem cells (CSCs) are present in the adult heart. CSCs play an important role in maintaining the balance of the number of myocardial cells. The purpose of this study was to examine characteristics of human CSCs and their correlation with clinical characteristics of patients. We collected heart auricles of 105 patients (age range, 1–78 years; mean, 55.6 ± 17.0 years) undergoing cardiac surgery to obtain CSCs. We assayed the percentage of c-kit positive (c-kit+) CSCs with flow cytometry. Plasma Nɛ-(carboxymethyl)lysine (CML) concentrations were measured by enzyme-linked immunosorbent assay. The percentage of c-kit+ CSCs was 4.96 ± 3.12% (0.98–17.17%), and this was significantly negatively correlated with age, the presence of diabetes mellitus (DM) and coronary heart disease (CHD) (r values were −0.797 [P < 0.01], −0.500 [P < 0.01] and −0.250 [P = 0.011], respectively). The percentage of c-kit+ CSCs was significantly negatively correlated with CML concentrations (r = −0.859, P < 0.01). The percentage of c-kit+ CSCs decreases with ageing and is further decreased in patients with DM and/or CHD. Furthermore, plasma CML concentrations may have potential as an indicator of the number of c-kit+ CSCs.
Methemoglobinemia: Pathogenesis, Diagnosis, and Management

The diagnosis of methemoglobinemia should be considered in patients presenting with cyanosis and hypoxia. A variety of frequently used medications are capable of inducing methemoglobinemia, with dapsone and benzocaine being common culprits. Unique features, such as a saturation gap and chocolate-brown-colored blood, can raise suspicion for methemoglobinemia. Typically, symptoms correlate with the methemoglobin level, and treatment with methylene blue is reserved for patients with significantly elevated methemoglobin levels. In the presence of comorbid conditions that impair oxygen transport, however, low-grade methemoglobinemia can become symptomatic and may warrant treatment.