Miracle-dz/UniFAR-FTUs huggingface dataset:
Pentanucleotide Repeat and Size Polymorphisms in the Apolipoprotein(a) Gene Are Associated with the Lipoprotein(a) Concentration in Chronic Hemodialysis Patients

The elevation of serum or plasma lipoprotein(a) [Lp(a)] levels is regarded as an independent risk factor for cardiovascular disease, and many previous reports demonstrated that Lp(a) levels in hemodialysis patients were significantly higher than in controls. The purpose of this study was to investigate the effect of a pentanucleotide repeat polymorphism [(TTTTA)n] in the 5′-flanking region of the apolipoprotein(a) [apo(a)] gene and of a size polymorphism of apo(a) for elevated Lp(a) concentrations observed in chronic hemodialysis patients. We studied 172 patients on chronic hemodialysis and 199 healthy adults. For analysis of the pentanucleotide repeat polymorphism, polymerase chain reaction products were loaded on polyacrylamide gel for electrophoresis. apo(a) size phenotyping was performed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting. The median level of Lp(a) in the patients was 14.2 mg/dl which was significantly higher than that in controls (12.0 mg/dl; p < 0.05). In the genotype of (TTTTA)8/8, the median Lp(a) level in the patients (15.9 mg/dl) was significantly higher than that in controls (13.0 mg/dl; p < 0.05). In the genotype of (TTTTA)8/8 with large-sized apo(a) isoforms (A16–A25), the patients had significantly higher Lp(a) levels than the controls (p < 0.05). In conclusion, increased Lp(a) levels in chronic hemodialysis patients were mainly attributed to the combination of eight repeats of the pentanucleotide polymorphism and large-sized isoforms of apo(a).
p73 is not Mutated in Meningiomas as Determined with a Functional Yeast Assay but p73 Expression Increases with Tumor Grade

The p53 gene is normally wild type in meningiomas. Since all three members of the p53 gene family recognize the same DNA sequence, tumors containing wild type p53 could decrease transactivation of p53 target genes by mutating either p63 or p73. In meningiomas the most likely target is p73, because loss of heterozygosity of the chromosomal band containing p73 is the commonest genetic lesion in these tumors. To screen p73 for mutations we have developed a functional assay which tests the ability of p73 to activate transcription from a p53‐responsive promoter in yeast. The assay correctly identified p73 mutants with mutations equivalent to hotspot mutations in p53, demonstrating that the assay can detect transcriptionally inactive p73. No mutations in p73 were identified in meningiomas. p73 RNA level was higher in more advanced tumors, but there was no correlation between the expression level of p73 and p21, a known p53 target gene. The yeast assay was also used to measure the intrinsic sensitivity of the p73 protein to mutagenesis. Like p53, p73 is exceptionally easy to inactivate as a transcription factor by point mutation. Taken together, these results indicate that p53 and p73 serve very different functions in tumors.
Autotransplantation of keloid in man

postoperative rapy ative only CONTRARY to expectation, keloid was not recognized by the ancients. The works of Hippocrates and Galen make no mention of a condition which one feels sure must have existed in the civilizations of Ancient Egypt, Greece, and Rome. The earliest description found in the literature is in a book (with the delightful title of ‘Treatise on Skin Diseases and Things of the Mind’) by Retz in
Effect of reduced water intake by lactating dairy cows on behaviour, milk yield and blood composition

A herd of lactating British Friesian cows was divided into two equal groups. After 14 days during which all the cows had free access to water one group (restricted) was allowed only 50 per cent of the voluntary water intake of the other group (control). After four days when the experiment was terminated, the milk yield of the restricted group had fallen to 74 per cent of that of the control group and their mean body-weight was reduced by 14 per cent. In the restricted group there were significant increases in the concentrations of urea, sodium, total protein and copper in serum, in the osmolality of serum, in the plasma activities of the enzymes creatine kinase and glutamate-oxaloacetate transaminase and in the packed cell volume of blood. The restricted cows behaved very aggressively around their water trough and spent more time in its vicinity. They spent less time lying down than the cows of the control group and some of them were not seen to drink and were withdrawn from the experiment before the end of four days. In a second experiment half the herd was allowed approximately 90 per cent of the water intake of the control group for 14 days. Decreases in milk yield and body-weight and changes in blood composition were much smaller and difficult to detect. However, changes in behaviour were still easily recognised although not as marked as in the first experiment.
Direct and indirect memory performance in patients with senile dementia

SYNOPSIS The performance of patients with a presumptive clinical diagnosis of Senile Dementia of the Alzheimer's Type was compared to that of a group of normal elderly on several memory and neuropsychological tasks. The patients were impaired on tasks of free and cued recall, but exhibited normal performance on a word-completion procedure similar to that used by Graf et al. (1984). Reasons for the discrepancy between these findings and those from related research which reports impairment of word completion in patients with Alzheimer's Disease are discussed. Of particular interest is the role the orientating task plays in word-completion performance.
PENGARUH LEVERAGE, PROFITABILITAS, DAN GOOD CORPORATE GOVERNANCE TERHADAP FINANCIAL DISTRESS (Studi Kasus pada Perusahaan Pertambangan yang Terdaftar di Bursa Efek Indonesia Tahun 2012-2016)

This study aims to determine the effect of Leverage, Profitability, and Good Corporate Governance to Financial Distress in mining sector companies listed on Indonesia Stock Exchange 2012-2016 either simultaneously or partially. The method in this research is quantitative research method. The method of analysis used in this research is logistic regression analysis using SPSS 21 software. Based on the result of this research, the result of the combination of independent variables consisting of leverage, profitability, and good corporate governance can explain or influence the dependent variable that is financial distress is 63.6% and the rest of 36.4% is explained by other factors outside the research. The results of this study also show that leverage, profitability, and good corporate governance have a significant simultaneous effect on financial distress. Partially, leverage, independent board of commissioners, and institutional ownership have no significant effect on financial distress, profitability and managerial ownership having a significant effect on financial distress in a negative direction. Keywords : Leverage, Profitability, Good Corporate Governance, Financial Distress.
Analysis of Membrane Protein Interactions with a Bacterial Adenylate Cyclase–Based Two‐Hybrid (BACTH) Technique

The bacterial two‐hybrid (BACTH, for “Bacterial Adenylate Cyclase‐based Two‐Hybrid”) technique is a simple and fast genetic approach to analyze protein‐protein interactions in vivo. In this system, the proteins of interest are genetically fused to two complementary fragments from the catalytic domain of Bordetella pertussis adenylate cyclase and co‐expressed in strains of Escherichia coli deficient in adenylate cyclase. Association of the hybrid proteins restores synthesis of cyclic AMP (cAMP), which then triggers the expression of catabolic operons such as the lactose operon or the maltose regulon. As BACTH uses a cAMP second messenger, the association between the chimeric proteins can take place at a distance from the transcription machinery. This technique is therefore particularly appropriate for studying interactions involving integral‐membrane or membrane‐associated proteins that may not be soluble in the cytoplasm, and/or that may only associate in the plane of the membrane. This unit describes the basic procedures to characterize protein‐protein interactions with the BACTH genetic system and to search for potential partners of known proteins. © 2017 by John Wiley & Sons, Inc.
The Sooner, the Worse? Association between Earlier Age of Sexual Initiation and Worse Adolescent Health and Well-being Outcomes

This cross-sectional study assesses the association between age of sexual initiation during adolescence and a selection of well-being outcomes regarding that first relationship. High-school adolescents from El Salvador (2,686) and from Peru (3,399) replied to a paper-pencil questionnaire. Those who were sexually initiated replied to several questions regarding their age at sexual initiation, condom use, satisfaction and reasons/circumstances for that sexual relationship. Approximately 19% of participants were sexually initiated (n = 1,179). After retaining participants with valid responses and with sexual initiation ages between 13 and 17, the final sample for this paper consisted of 996 sexually initiated participants (526 Salvadorians and 470 Peruvians). Multiple logistic regression analyses showed that those who initiated sex at earlier ages had worse outcomes compared to those who initiated at older ages. Specifically, they had lower odds of having used a condom, of having good memories of that experience and of having had that first relationship because they were in love. Conversely, they had higher odds of having had that first sexual relationship as a result of peer pressure (“Most of my friends already had sex”), because of partner pressure (“I was afraid to lose him/her,” “My partner told me he/she would leave me” or “I did not know how to say no to a person who insisted”), or as a consequence of different forms of impaired autonomy (“I was under the influence of alcohol or drugs” or “As a consequence of seeing sexual images”). Results show that sex at earlier ages is associated with worse adolescent health and well-being outcomes.
Profile of Cuban Women Involved in Sex Tourism—A Financial Perspective

With the country’s lack of access to financial resources and wages being low in the formal sector of employment, some women in Cuba have devised sex tourism as the way of survival and fulfilling their family and personal needs. This paper identifies the profile of those Cuban women who are involved in the sex tourism in Cuba and examines how this industry is financially benefiting them. This study follows the method of reviewing other research literatures on sex tourism in Cuba, analyzing and differentiating them with one another. The study first discusses Cuba as a tourist destination, the kind of profile the women carries with themselves by being in the sex tourism industry and the existing links of the sex tourism and the local residents in Cuba with its financial impacts. The ways and the aspects in which sex tourism is financially benefitting the local residents especially the women are revealed. The conclusion discusses the importance of sex tourism to Cuba through the association or the local women with the financial impacts of sex tourism and defining the women’s nature of engagement, and the need for detailed future research on other broader facets surrounding this study.
Frequency and latency of social interaction in an inclusive kindergarten setting

This study investigated the frequency and latency of naturally occurring social interaction with typically developing children and those with autism in inclusive kindergarten settings. The children with autism were also subdivided into two groups according to intellectual functioning in order to analyze frequency and latency of social interaction in relation to degree of disability. The results showed a significant difference in frequency of social interaction between the typical children and those with autism. There was no difference between the groups on latency to initiate interaction. However, shorter latency was associated with higher frequency in the typical group but not in the group of children with autism. Significant differences in IQ and adaptive functioning were found between the children with autism who showed interaction and those who did not. The results for the typical children may be used as benchmark values for the assessment of treatment outcome for children with autism.
Influence of Chitosan Nanoparticles as the Absorption Enhancers on Salvianolic acid B In vitro and In vivo Evaluation

Background: Salvianolic acid B (SalB) represents the most abundant and bio-active phenolic constituent among the water-soluble compounds of Salvia miltiorrhiza. But the therapeutic potential of SalB has been significantly restricted by its poor absorption. Methods: In this study, chitosans (CS) and CS nanoparticles (NPs) with different molecular weights (MWs), which have influence on the absorption of SalB, was also investigated. Results: As a preliminary study, water-soluble CS with various MWs (3, 30, 50, and 100 kDa) was chosen. We investigated the MW-dependent Caco-2 cell layer transport phenomena in vitro of CS and NPs at concentrations (4 μg/ml, w/v). SalB, in presence CS or NPs has no significant toxic effect on Caco-2 cell. As the MW increases, the absorption enhancing effect of CS increases. However, as the MW decreases, the absorption enhancing effect of NPs increases. The AUC 0-∞ of the SalB-100 kDa CS was 4.25 times greater than that of free SalB. And the AUC 0-∞ of the SalB-3 kDa NPs was 16.03 times greater than that of free SalB. Conclusion: CS and NPs with different MWs as the absorption enhancers can promote the absorption of SalB. And the effect on NPs is better than CS.
Secure Broadcasting Using the Secure Lock

The authors discuss secure broadcasting, effected by means of a secure lock, on broadcast channels, such as satellite, radio, etc. This lock is implemented by using the Chinese Remainder theorem (CRT). The secure lock offers the following advantages: only one copy of the ciphertext is sent; the deciphering operation is efficient; and the number of secret keys held by each user is minimized. Protocols for secure broadcasting using the secure lock, based on the public-key cryptosystem as well as the private-key cryptosystem, are presented. >
Neural Image Captioning for Intelligent Vehicle-to-Passenger Communication

Motivated by the future need of intelligent systems for vehicle-to-passenger communication in autonomous vehicles, we implement two models for automatic image caption generation based on the neural encoder-decoder framework. Following an extensive hyperparameter search, our non-attention based model achieves performance on the MSCOCO dataset highly comparable to that of its reference model. Our attention based model does however fail to exceed this performance, despite the attention mechanism appearing to function as intended. This leads to a discussion of possible causes and what architecture modifications that might be needed.
Effects of Antidepressants on Behavioral Assessment in Adolescent Rats

The forced swim animal model is a common behavioral test for assessing depression in rodents and testing the efficiency of anti-depressants drugs. As originally developed by Porsolt in 1977, a rat is forced to swim for 15 minutes in a narrow cylinder from which there is no escape. After an initial struggle the rat becomes immobile, that is, it floats while making only movements necessary to keep its head above the water. Administration of clinically effective antidepressant drugs prior to a second 5 minutes test swim session decreases the time an animal is immobile ______________________________________________________________________________ * Post Doctoral at Creighton University, Psychiatry Department, Omaha, NE, USA Assistant Professor of Pharmacology (Currently) Department of Pharmacology and Toxicology King Khalid University, Abha, Saudi Arabia **Assistant Professor of Psychiatry Department of Psychiatry, College of Medicine-Internal Medicine King Khalid University, Abha, Saudi Arabia Email : hasanalamri@ymail.com
Aspects of the neuroendocrine regulation of body weight homeostasis.

Comité de rédaction A. Belcourt (Strasbourg), M. -H. Bernard (Lyon) Ph. Bouchard (Paris), J. Bringer (Montpellier), T. Brue (Marseille), J.-M. Brun (Dijon), M. Chupin (Nantes), B. Delemer (Reims), N. Jeandidier (Strasbourg), V. Lassmann-Vague (Marseille), J. Leclère (Nancy), P. Lecomte (Tours), P. Lefebvre (Liège), Y. Lorcy (Rennes), Y. Morel (Lyon), H. Rochefort (Montpellier), V. Rohmer (Angers), J.-L. Sadoul (Nice), J. Saez (Lyon), G. Slama (Paris), H. Vaudry (Mont Saint-Aignan), J.-L. Wemeau (Lille), G. Weryha (Vandœuvre), Indexé dans, Indexed in : Biosis, Chemical Abstract, Current
PENGARUH BEBAN PAJAK TANGGUHAN, PERENCANAAN PAJAK DAN PROFITABILITAS TERHADAP MANAJEMEN LABA PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2012 – 2017

Riska Nirwana Sari. 022114064. Akuntansi Perpajakan. Beban Pajak Tangguhan, Perencanaan Pajak, dan Profitabilitas terhadap Manajemen Laba pada Perusahaan Manufaktur yang terdaftar di Bursa Efek Indonesia Periode 2012-2017. Dibawah bimbingan . Arief Tri Hardiyanto dan Patar Simamora. 2019. Manajemen laba merupakan tindakan manajer untuk memilih kebijakan akuntansi dari suatu standar tertentu untuk mempengaruhi laba yang akan terjadi menjadi seperti yang mereka inginkan melalui pengelolaan faktor internal yang dimiliki atau digunakan perusahaan. Praktik manajemen laba bisa dilakukan melalui beban pajak tangguhan dimana besar kecilnya nilai beban pajak tangguhan dari tahun ke tahun ,sehingga beban pajak tangguhan dapat memprediksi dalam melakukan manajemen laba yang dilakukan oleh manajer agar dapat menghindari kerugian atau pelaporan penurunan laba. Perencanaan pajak digunakan untuk manajemen lba dengan cara mengatur seberapa besar laba yang dilaporkan, sehingga masuk dalam indikasi adanya praktik manajemen laba.Dan profitabilitas juga digunakan untuk mendekteksi manajemen laba karena dimana semakin besar profitabilitas maka semakin besar peluang probabilitas perusahaan dalam melakukan manajemen laba. Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh beban pajak tangguhan, perencanaan pajak dan profitabilitas terhadap manajemen labapada perusahaan manufaktur . Data yang digunakan dalam penelitian ini adalah data sekunder berupa laporan keuangan yang telah diaudit pada perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2012-2017.Penentuan sampel dilakukan dengan menggunakan metode purposive sampling . Ada 11 perusahaan yang diuji menggunakan regresi linier berganda,uji asumsi klasik, dan hipotesis. Hasil penelitian dapat disimpulkan bahwa: 1) Beban pajak tangguhan berpengaruh secara signifikan terhadap manajemen laba, 2) Perencanaan pajak tidak berpengaruh secara signifikan terhadap manajemen laba, 4) Profitabilitas berpengaruh secara signifikan terhadap manajemen laba 3) Beban pajak tangguhan, perencanaan pajak dan profitabilitas secara bersama-sama berpengaruh secara signifikan terhadap keputusan manajemen laba. Berdasarkan hasil penelitian maka diperoleh kesimpulan bahwa beban pajak tangguhan, perencanaan pajak dan profitabilitas berpengaruh bersama sama secara signifikan terhadap keputusan manajemen laba. Penelitian selanjutnya hendaknya menganalisis praktek manajemen laba yang dilakukan perusahaan tidak hanya pada pajak tangguhan tetapi ada juga pada komponen lainnya contohnya akrual, leverage dan indikator lain yang mendukung adanya praktik manajemen laba yang dilakukan oleh manajemen perusahaan. Kata kunci : Beban Pajak Tangguhan, Perencanaan Pajak, Profitabilitas dan Manajemen Laba.
Influence of the Corn Resistance Gene Mv on the Fitness of Peregrinus maidis (Hemiptera: Delphacidae) and on the Transmission of Maize Mosaic Virus (Rhabdoviridae: Nucleorhabdovirus)

ABSTRACT Crops that are resistant to pests and pathogens are cost-effective for the management of pests and diseases. A corn (Zea mays L.) breeding program conducted in Hawaii has identified a source of heritable resistance to maize mosaic virus (MMV) (Rhabdoviridae: Nucleorhabdovirus). This resistance is controlled by the gene Mv, which has been shown to have a codominant action. To date, no studies have examined whether the resistance associated with this gene affects only MMV or whether it also affects the insect vector, the corn planthopper Peregrinus maidis (Ashmead) (Hemiptera: Delphacidae). Here, we examined the life history of the corn planthopper and its ability to transmit MMV on near isogenic lines that were homozygous dominant (Mv/Mv), homozygous recessive (mv/mv), or heterozygous (Mv/mv) for the gene. A field trial was also conducted to study the colonization of the corn plants with different genotypes by the planthopper. Although field observations revealed slightly lower densities of planthoppers on corn with the genotype Mv/Mv than on the inbreds with the genotype mvlmv and their hybrids with the genotype Mvlmv, laboratory assays showed no effects of the gene on planthopper development, longevity, or fecundity. In the field, the corn lines Mv/Mv had a lower incidence of MMV-infected plants. However, in the greenhouse, the transmission of MMV to corn seedlings did not differ across the near isogenic lines, although the corn lines Mv/Mv showed a delayed onset of symptoms compared with the corn lines mvlmv and Mvlmv. The acquisition of MMV by corn planthoppers on the corn genotypes Mv/Mv and Mvlmv averaged 0.2, whereas the acquisition on the corn genotypes mvlmv averaged >0.3. Our results show that the Mv gene does not influence the fitness of the planthopper vector, suggesting that it may confer resistance by other means, possibly by limiting virus replication or movement within the host plant.
Consensual and Entrepreneurial Culture: Insights from Organisational Culture and Human Resource Development Policy in Nigerian Banks

This study contributes to an understanding of consensual and entrepreneurial culture in organisations within the context of communicating organisational culture through human resource policy. Given that consensual and entrepreneurial culture has the potential to shape employee attitudes and work behaviours towards the attainment of business efficiency and sustainability, this study examined the relationship between organisational culture and Human Resource (HR) development policy. Two hypotheses were formulated and tested to establish the significance of the relationship between organisational culture and HR development policy. We adopted a quantitative approach, utilising a structured questionnaire (n=305) and other documented evidence. The study used a combination of convenience sampling and simple random sampling techniques to select the respondents. The findings revealed that there is a significant relationship between organisational culture and HR development policy. It was found that consensual culture as a dimension of organisational culture has the greatest influence on HR development policy, and consequently the entrepreneurial mentality and creativity within the organisation. We conclude that there is a strong positive relationship between organisational culture and HR development policy as an antecedent of HR/organisational outcome in the Nigerian banking sector. This paper recommends that consensual and entrepreneurial cultures are crucial for business sustainability in the knowledge-based global economy. DOI: 10.5901/mjss.2014. v5n20p101