Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving outcomes for neonates with gastroschisis in low-income and middle-income countries: a systematic review protocol

Introduction There is a significant disparity in outcomes for neonates with gastroschisis in high-income countries (HICs) compared with low-income and middle-income countries (LMICs). Many LMICs report mortality rates between 75% and 100% compared with <4% in HICs. Aim To undertake a systematic review identifying postnatal interventions associated with improved outcomes for gastroschisis in LMICs. Methods and analysis Three search strings will be combined: (1) neonates; (2) gastroschisis and other gastrointestinal congenital anomalies requiring similar surgical care; (3) LMICs. Databases to be searched include MEDLINE, EMBASE, Scopus, Web of Science, ProQuest Dissertations and Thesis Global, and the Cochrane Library. Grey literature will be identified through Open-Grey, ClinicalTrials.gov, WHO International Clinical Trials Registry and ISRCTN registry (Springer Nature). Additional studies will be sought from reference lists of included studies. Study screening, selection, data extraction and assessment of methodological quality will be undertaken by two reviewers independently and team consensus sought on discrepancies. The primary outcome of interest is mortality. Secondary outcomes include complications, requirement for ventilation, parenteral nutrition duration and length of hospital stay. Tertiary outcomes include service delivery and implementation outcomes. The methodology of the studies will be appraised. Descriptive statistics and outcomes will be summarised and discussed. Ethics and dissemination Ethical approval is not required since no new data are being collected. Dissemination will be via open access publication in a peer-reviewed medical journal and distribution among global health, global surgery and children’s surgical collaborations and international conferences. Conclusion This study will systematically review literature focused on postnatal interventions to improve outcomes from gastroschisis in LMICs. Findings can be used to help inform quality improvement projects in low-resource settings for patients with gastroschisis. In the first instance, results will be used to inform a Wellcome Trust-funded multicentre clinical interventional study aimed at improving outcomes for gastroschisis across sub-Saharan Africa. PROSPERO registration number CRD42018095349.
Childhood Affective Indicators of Risk for Adulthood Psychopathology: The New York High-Risk Project Findings

There are relatively few investigations of the emotion expressivity of children at risk for the later development of schizophrenia and schizophrenia-spectrum disorders. Using data from the New York High-Risk Project, we compared children’s emotional expressivity during a semi-structured videotaped interview. Data were coded for 173 child subjects: 61 with schizophrenic parents (HRSz); 54 with affectively ill parents (HRAff); and 58 with psychiatrically “normal” parents (NC). A child’s affective responses were rated for the presence of discrete positive, negative, or neutral emotions by coders naive to group membership. Responses were also rated for anxiety, flat affect, inappropriate affect, and emotional withdrawal/disengagement. Compared with the two other two groups, HRSz children displayed significantly more negative affect in response to questions regarding their most negative experiences and, when questioned about their self-concept, they displayed significantly less positive affect. Both HRSz and HRAff children showed more inappropriate affect than NC children. Significantly more HRSz children were rated as demonstrating a lack of emotional engagement. Children making inappropriate displays of positive affect while discussing a negative topic were most likely to manifest a psychiatric disorder as an adult. These findings suggest that inappropriate affect may be a nonspecific indicator of risk for psychopathology. Emotional withdrawal in childhood may be a potential indicator of risk for schizophrenia.
The Association Between Helicobacter Pylori Infection and Liver and Biliary Tract Disorders

Helicobacter Pylori (HP) persistently colonizes the stomach in about 50% of the globe population and it is the main risk factor for peptic ulcer, as well as for gastric adenocarcinoma and MALT gastric lymphoma. The treatment for HP revolutionized the management of the peptic ulcer disease, providing permanent healing in many cases. Preventing colonization of HP would be the primary prevention of gastric malignancy and peptic ulceration. At the same time, the presence of HP provides protection for some diseases (gastroesophageal reflux disease and its complications, esophageal adenocarcinoma, asthma), the eradication of the microorganism having negative repercussions. HP has an increasingly recognized role in other extragastric pathologies. Thus, immune thrombocytopenic purpura has improved after treating HP infection. There are controversial association with ischemic heart disease and cerebrovascular disease. The current article highlights an important association between HP infection and a range of hepatobiliary disorders such as biliary lithiasis (where even an etiological role is involved), cholestatic syndromes (primary sclerosing cholangitis and primary biliary cholangitis), chronic hepatitis B virus, chronic hepatitis C virus, with an evolution towards cirrhosis and hepatocellular carcinoma.
Effect of health education intervention conducted by Primary Health Care workers on oral health knowledge and practices of nursing mothers in Lagos State

Educational interventions on oral health care is traditionally carried out mainly by oral health workers in Nigeria. Despite the introduction of the National Oral Health Policy, oral health services/education is virtually non-existent in PHC centres in Nigeria. This study sought to determine the effect of a health education intervention delivered by Community Health Officers (CHO) on the oral health knowledge and practices of mothers attending a PHC centre in Lagos State. A pre-experimental, Before- After study design was employed. An interviewer- administered questionnaire was administered at baseline to assess the oral health care knowledge and practices of 267 mothers who enrolled in the programme. After enrolling the participants, CHO’s previously trained commenced a health education intervention on oral health. The intervention, which consisted of 2 lecture sessions, a demonstration session and a return demonstration session, utilising flipcharts and health information leaflets spanned a six-month period. Oral health knowledge and practices of participating mothers was evaluated 3 and 6 months after the intervention commenced using a standardised checklist. Data entry and analysis was done using SPSS version 20, P-value of <0.05 was considered significant. The mean oral health knowledge score at baseline was 4.58 (±1.37) while at 3-month and 6-month postintervention the mean scores were 4.68 (±0.97) and 4.96 (±0.49), respectively. There was a statistically significant increase (P=0.000) in the mean knowledge scores at 6 months post-intervention. Mothers who were 36 years or older and those with more than 12 years education displayed significantly better knowledge scores (P<0.05). Most (78.3%) reported using cotton wool or foam with water for their infants’ oral hygiene. By the second post-intervention visit, there was a significant change in the perception of the mothers on correct oral hygiene tool for infants (52.3%; P=0.000). Furthermore the percentage of mothers actually using toothbrush to clean their child’s mouth (98.1%; P=0.000) had increased. The oral health knowledge of the participants increased significantly following the intervention especially at the 6-month evaluation. PHC workers can successfully carry out oral health educational interventions at PHC level. The greatest value will occur with reinforced repetition of the messages.
A Pilot Study on Neonatal Surgical Mortality: A Multivariable Analysis of Predictors of Mortality in a Resource-Limited Setting

Purpose: The aim of this research is to study the predictors of neonatal surgical mortality (NSM)-defined as in-hospital death or death within 30 days of neonatal surgery. Materials and Methods: All neonates operated over the study period of 18 months were included to evaluate NSM. The evaluated preoperative and intraoperative variables were birth weight, gestation age, age at presentation, associated anomalies, site and duration of surgery, intraoperative blood loss, and temperature after surgery. Assessed postoperative variables included the need for vasopressors, postoperative ventilation, sepsis, reoperations, and time taken to achieve full enteral nutrition. Univariate and multivariate logistic regression was applied to find the predictors of mortality. Results: Based on patient's final outcome, patients were divided into two groups (Group 1-survival, n = 100 and Group 2-mortality, n = 50). Incidence of NSM in this series was 33.33%. Factors identified as predictors of NSM were duration of surgery >120 min (P = 0.007, odds ratio [OR]: 9.76), need for prolonged ventilation (P = 0.037, OR: 5.77), requirement of high dose of vasopressors (P = 0.003, OR: 25.65) and reoperations (P = 0.031, OR: 7.16 (1.20–42.81). Conclusion: NSM was largely dependent on intraoperative stress factors and postoperative care. Neonatal surgery has a negligible margin of error and warrants expertize to minimize the duration of surgery and complications requiring reoperations. Based on our observations, we suggest a risk stratification score for neonatal surgery.
Review of the ant genus Meranoplus Smith, 1853 (Hymenoptera: Formicidae) in the Arabian Peninsula with description of a new species M. mosalahi sp. n. from Oman

The species of Meranoplus Smith, 1853 of the Arabian Peninsula are reviewed based on the worker caste. Two species are recognized, keyed, and illustrated by Scanning Electron Microscope images (SEM), Meranoplus mosalahi and M. pulcher, Sharaf, 2014. Meranoplus mosalahi sp. n. is described from the Dhofar Governorate, Oman based on the worker caste. The new species belongs to the M. magrettii-group and closely resembles M. pulcher Sharaf, 2014 from the Kingdom of Saudi Arabia (KSA), from which it can be distinguished by the bicolored body, the shallowly concave anterior clypeal margin, the absence of well-developed anterior clypeal teeth, the fewer irregular longitudinal cephalic rugae, and the feeble longitudinal rugae on posterior face of petiolar node.
Benificial Effect of Stachydrine on the Traumatic Brain Injury Induced Neurodegeneration by Attenuating the Expressions of Akt/mTOR/PI3K and TLR4/NFκ-B Pathway

Abstract Present investigation aims to explore the protective effect of stachydrine against traumatic brain injury (TBI) and also investigate the molecular mechanism of its action. TBI was induced by the fall a hammer (450 g) from the height of 1.5 m. and later stachydrine was administered for 2 weeks starting 2 hr after the induction of TBI. Effect of stachydrine was determined by estimating modified neurological severity score (mNSS), percentage of water content in the brain and cognitive dysfunction in TBI rats. Moreover western blot assay, histopathology and enzyme linked immunosorbent assay (ELISA) tests were used to determine the effect of stachydrine on TBI injured rats. Result of the report suggests that stachydrine reduces the mNSS and percentage of water content in the brain and also attenuates the cognitive dysfunction in TBI injured rats. However data of western blot assay reports that stachydrine reduces the expression of PI3K/m-TOR/Akt pathway in the brain tissues of TBI rats. Concentration of interleukin (IL-1β), tumor necrosis factor-α (TNF-α) and interferon gamma (INF-γ) was reduces in stachydrine treated group than TBI group. Moreover expression of Nuclear factor-κB/Toll-like receptor 4 (NF-κB/TLR-4) protein was also decreased in stachydrine treated group than TBI group. Histopathology study on brain tissue reveals that the percentage of apoptotic cells was also reduced in stachydrine treated group than TBI group. Data of this investigation concludes that stachydrine protects the neuronal injury by attenuating the phosphatidylinositide 3-kinases/mammalian target of rapamycin/Protein kinase B (PI3K/m-TOR/Akt) and NF-κB/TLR-4 pathway in TBI injured rats.
Technical and Training Related Aspects of Resistance Training Using Blood Flow Restriction in Competitive Sport - A Review

Abstract Blood flow restriction (BFR) combined with resistance training (RT-BFR) shows significant benefits in terms of muscle strength and hypertrophy. Such effects have been observed in clinical populations, in groups of physically active people, and among competitive athletes. These effects are comparable or, in some cases, even more efficient compared to conventional resistance training (CRT). RT-BFR stimulates muscle hypertrophy and improves muscle strength even at low external loads. Since no extensive scientific research has been done in relation to groups of athletes, the aim of the present study was to identify technical, physiological and methodological aspects related to the use of RT-BFR in competitive athletes from various sport disciplines. RT-BFR in groups of athletes has an effect not only on the improvement of muscle strength or muscle hypertrophy, but also on specific motor abilities related to a particular sport discipline. The literature review reveals that most experts do not recommend the use RT-BFR as the only training method, but rather as a complementary method to CRT. It is likely that optimal muscle adaptive changes can be induced by a combination of CRT and RT-BFR. Some research has confirmed benefits of using CRT followed by RT-BFR during a training session. The use of BFR in training also requires adequate progression or modifications in the duration of occlusion in a training session, the ratio of exercises performed with BFR to conventional exercises, the value of pressure or the cuff width.
Epidemiology of sports injuries in basketball: integrative systematic review

Introduction Basketball is a contact sport with complex movements that include jumps, turns and changes in direction, which cause frequent musculoskeletal injuries in all regions of the body. Objective This is an integrative systematic review of the epidemiology of musculoskeletal injuries in basketball. Methods This is an integrative review based on the following sources of information: PubMed/MEDLINE, Embase, LILACS, BBO-Biblioteca Brasileira de Odontologia, IBECS-Índice Bibliográfico Espanhol em Ciências da Saúde, nursing journals, dental journals and core clinical journals in the last 10 years with studies addressing the general epidemiology of sports injuries in basketball. Results In total, 268 articles were selected, of which 11 were eligible for the integrative review. A total of 12 960 injuries were observed, most of which occurred in the lower limbs (63.7%), with 2832 (21.9%) ankle injuries and 2305 (17.8%) knee injuries. Injuries in the upper limbs represented 12%–14% of the total injuries. Children and adolescents received head injuries more often compared with the other age and skill categories. In the adult category, there was an increased prevalence of injuries in the trunk and spine. In the upper limbs, hands, fingers and wrists were affected more frequently than the shoulders, arms and forearms. In the masters’ category, there was an increase in the incidence of thigh injuries. Conclusion The lower limbs were the most affected, with the ankle and knee joints having the highest prevalence of injuries regardless of gender and category. Further randomised studies, increased surveillance and epidemiological data collection are necessary to improve knowledge on sports injuries in basketball and to validate the effectiveness of preventive interventions.
Waving goodbye to contrast: self-generated hand movements attenuate visual sensitivity

It is well known that the human brain continuously predicts the sensory consequences of its own body movements, which typically results in sensory attenuation. Yet, the extent and exact mechanisms underlying sensory attenuation are still debated. To explore this issue, we asked participants to decide which of two visual stimuli was of higher contrast in a virtual reality situation where one of the stimuli could appear behind the participants’ invisible moving hand or not. Over two experiments, we measured the effects of such “virtual occlusion” on first-order sensitivity and on metacognitive monitoring. Our findings show that self-generated hand movements reduced the apparent contrast of the stimulus. This result can be explained by the active inference theory. Moreover, sensory attenuation seemed to affect only first-order sensitivity and not (second-order) metacognitive judgments of confidence.
The Mediation Effect of Perceived Social Support and Perceived Stress on the Relationship Between Emotional Intelligence and Psychological Wellbeing in Male Athletes

Abstract This study aimed to examine the relationship between emotional intelligence (EI) and psychological wellbeing in a three-month follow-up study of male athletes. In addition, we examined the mediating role of perceived social support and perceived stress on the relationship between EI and psychological wellbeing. The sample included 398 male athletes who completed measures of emotional intelligence (Schutte Self-Report Inventory), psychological wellbeing (Ryff Psychological Wellbeing Scale; SSRI), perceived social support (Multidimensional Scale of Perceived Social Support), and perceived stress (Perceived Stress Scale–10). Results from structural equation modelling procedures identified that perceived social support and perceived stress partially mediated the association between EI and psychological wellbeing. The sequential mediation effects of perceived social support–perceived stress on the relations between EI and wellbeing were confirmed. Finally, limitations and recommendations for future research were considered
MAIT cells: potent major cellular players in the IL-17 pathway of spondyloarthritis?

Spondyloarthritis (SpA) refers to a group of chronic inflammatory disorders that share common clinical, biological and pathophysiological characteristics. According to the Assessment of SpondyloArthritis international Society classification criteria, these inflammatory rheumatic diseases are subdivided into axial (Ax) SpA (including both radiographic (r) and non-radiographic (nr) forms) and peripheral SpA. Radiographic AxSpA (rAxSpA) corresponds to ankylosing spondylitis (AS), the prototypic and most common form of the disease. The clinical presentation of SpA is heterogeneous with musculoskeletal features (synovitis, sacroiliitis, spinal inflammation, enthesitis, dactylitis), but also extra-articular manifestations (psoriasis, anterior uveitis and inflammatory bowel diseases (IBDs)). One hallmark of the disease, and especially of AxSpA, is the presence of radiographic changes of the sacroiliac joints (SIJs), but also the development of progressive ossifications at entheseal sites.1 Although HLA-B27 has been identified as a major genetic marker of susceptibility to the disease, the pathophysiology of SpA still remains imperfectly understood. For roughly 15 years, TNF-α has been known as a leading inflammatory cytokine associated with joint inflammation in SpA. With the development of biological treatments, that is, TNF inhibitors (TNFi), the management of patients with SpA has considerably progressed. However, not all patients primarily respond to these treatments, indicating the involvement of other inflammatory mediators. In fact, the IL-23/IL-17A axis has been identified as another major contributing pathway to inflammatory reaction in SpA.2 Indeed, genome-wide studies performed in patients with AS have identified polymorphisms in the IL-23 receptor ( IL-23R ) as a strong protective genetic factor.3 This polymorphism also provides protection against IBD and psoriasis through impairment of IL-17A production. The interaction of IL-23 (a heterodimeric cytokine with an IL-12/IL-23 p40 common subunit and a p19 IL-23 specific component) with its receptor leads to activation of signal transducer and activator of transcription 3 (STAT3), which in turn induces the expression of …
Prevention of mother-to-child transmission of hepatitis B virus in Burkina Faso: Screening, vaccination and evaluation of post-vaccination antibodies against hepatitis B surface antigen in newborns

The low rate of screening for hepatitis B virus (HBV) in pregnant women is a highrisk factor for its vertical transmission. The objectives of this study were: i) to screen pregnant women for HBV infection; ii) vaccinate all children from birth against HBV regardless their mother HBV status; and iii) evaluate after 7 months of birth the level of their AbHBs among babies who received HBV vaccine at birth. Serological markers of HBV (HBsAg, HBeAg, AbHBs, AbHBe, and AbHBc) were determined on venous blood samples from 237 pregnant women and their children using the Abon Biopharm Kit. One hundred and two (102) children received the three doses of the EUVAX B® vaccine respectively at birth, two months and four months of life. Seven months after delivery, venous blood samples were collected from mothers and their children. Antibodies against hepatitis B surface antigen (AbHBs) were measured in vaccinated children using the ELISA Kit AbHBs Quantitative EIA. DNA extraction was performed on samples from HBV-seropositive mothers and their children using the Ribo Virus (HBV Real-TM Qual) Kit and for Real Time PCR, the HBV Real-TM Qual Kit was used. Serological diagnosis in pregnant women revealed 22 (9.28%) hepatitis B surface antigen (HBsAg) positive samples of which 21 were positive for viral DNA by real-time PCR. Among the 22 HBsAg+ women, five (05) transmitted the virus to their children with a vertical transmission rate of 22.73%. A transmission rate of 23.81% (5/21) was found with the PCR method. Analysis of AbHBs levels revealed that 98.31% of the children had an average concentration of 218.07 ± 74.66 IU/L, which is well above the minimum threshold for protection (11 IU/L). This study has confirmed that vertical transmission of HBV is a reality in Burkina Faso and that vaccination at birth would significantly reduce this transmission.
Effects of the Pitch Surface on Displacement of Youth Players During Soccer Match-Play

Abstract The aim of this study was to analyze the effect of different pitch surfaces (artificial turf, natural turf and dirt field) on positioning and displacement of young soccer players (age: 13.4 ± 0.5 yrs; body height: 161.82 ± 7.52 cm; body mass: 50.79 ± 7.22 kg and playing experience: 3.5 ± 1.4 yrs). Data were collected using GPS units which allowed to calculate spatial distribution variability, assessed by measuring entropy of individual distribution maps (ShannEn). Ellipsoidal areas (m2) representing players’ displacement on the pitch, centred on the average players’ positional coordinates, were also calculated, with axes corresponding to the standard deviations of the displacement in the longitudinal and lateral directions. Analysis of variance (ANOVA) was used to evaluate differences between pitch surfaces and across players’ positions. There was significant effect in positioning (η2 = 0.146; p < 0.001) and displacement (η2 = 0.063; p < 0.05) by the players between pitch surfaces. A dirt field condition induced an increase in the players’ movement variability, while players’ displacement was more restricted when playing on artificial turf. Also, there were significant effects on positioning (η2 = 0.496; p < 0.001) and displacement (η2 = 0.339; p < 0.001) across players’ positions. Central midfielders presented the greatest movement variability and displacement while fullbacks showed the lowest variability. Subsequently, the results may contribute to implement strategies that optimise players’ performance in different surface conditions.