Miracle-dz/UniFAR-FTUs huggingface dataset:
SPADE, a new statistical program to estimate habitual dietary intake from multiple food sources and dietary supplements.

BACKGROUND For the evaluation of both the adequacy of intakes and the risk of excessive intakes of micronutrients, all potential sources should be included. In addition to micronutrients naturally present in foods, micronutrients can also be derived from fortified foods and dietary supplements. In the estimation of the habitual intake, this may cause specific challenges such as multimodal distributions and heterogeneous variances between the sources. OBJECTIVE We present the Statistical Program to Assess Dietary Exposure (SPADE) that was developed to cope with these challenges in one single program. METHOD Similar to other methods, SPADE can model habitual intake of daily and episodically consumed dietary components. In addition, SPADE has the option to model habitual intake from dietary supplements. Moreover, SPADE offers models to estimate habitual intake distributions from different sources (e.g., foods and dietary supplements) separately and adds these habitual intakes to get the overall habitual intake distribution. The habitual intake distribution is modeled as a function of age, and this distribution can directly be compared with cutoff values to estimate the proportion above or below. Uncertainty in the habitual intake distribution and in the proportion below or above a cutoff value is quantified with ready-for-use bootstrap and provides 95% CIs. RESULTS SPADE is implemented in R and is freely available as an R package called SPADE.RIVM. The various features of SPADE are illustrated by the estimation of the habitual intake distribution of folate and folic acid for women by using data from the Dutch National Food Consumption Survey 2007-2010. The results correspond well with the results of existing programs. CONCLUSION SPADE offers new features to existing programs to estimate the habitual intake distribution because it can handle many different types of modeling with the first-shrink-then-add approach.
Project Communication Management in Industrial Enterprises (Step by Step)

Communication is the basis of everything and is thus the key to effective project management. The question is “What is the relationship between the project management and communication? ” Effective communication is one of the main elements of project management. Communication is a critical part between people, information, and ideas, and communication is the basis for project performance in organization. This chapter will be focused on “project communication management step by step. ” The chapter deals with all steps of project communication management which are defined as a combination of logical-related communication methods, tools, and techniques for a successful initialization, planning, implementation, control and administrative closure of the project communication. In the chapter communication environment (communication strategy, organizational structure), communication channel (communication methods, tools, frequency, and support of communication), communication cognitive (communication differences and skills), and communication system (feedback system and system of sharing and distribution of information) will be described.
Revisiting Poor Insight into Illness in Anorexia Nervosa: True Unawareness or Conscious Disagreement?

Background. To investigate and validate a novel approach to distinguishing between two possible sources of poor insight in anorexia nervosa: true unawareness, in which a patient is not aware that other people think there is a problem, and disagreement, in which a patient does recognize that others think there is a problem. Methods. Thirty-nine patients with anorexia nervosa or eating disorder not otherwise specified–anorexia nervosa were given two versions of the Scale of Unawareness of Mental Disorder (SUMD), one in which they were asked about their own opinion and one in which they were asked about their clinicians’ opinion. Clinicians also completed the SUMD with their opinion about the patient’s illness. Patients and clinicians both also completed a Visual Analog Scale assessing treatment acceptance. Results. About 57% of the overall level of poor insight was explained by disagreement. Prediction of treatment acceptance was significantly improved when poor insight was broken down into true unawareness and disagreement. Conclusions. These data suggest that impaired insight in anorexia nervosa is an additive outcome of true unawareness and disagreement. (Journal of Psychiatric Practice 2014;20:85–93)
Replication of Internet Privacy Concerns in the Mobile Banking Context

This study is a conceptual replication of the work of Hong and Thong (2013), who developed the Internet Privacy Concerns scale to measure individuals’ concerns regarding how personal information is handled by websites. We adapt the wording of the original survey items to the context of mobile banking and follow the same procedures to assess the scale. The replication results reinforce the stability and applicability of the scale over the years and in different scenarios. In contrast with the original study, however, we detect a high correlation between the Control and Awareness dimensions, suggesting the design of an additional second-order dimension that we label “exposure management” (individuals’ consciousness about existing controls that mitigate the risks of personal data loss).
Leukoreduction of blood components

During the past year, blood component therapy witnessed two quite contradictory trends in the area of leukoreduction. On the one hand, the year saw widespread forced implementation of leukoreduction by several national blood suppliers, including the American Red Cross, who refused to sell hospitals nonleukoreduced blood. The forced implementation came at high cost to hospitals and with the strong endorsement of the US Food and Drug Administration, which stopped short of mandating universal leukoreduction in the United States. On the other hand, the year saw the publication of several pivotal clinical trials that failed to demonstrate significant patient benefit from the use of leukoreduced blood components. The emerging scientific and clinical evidence reviewed in this article demonstrates that leukoreduction technology is an effective means to reduce the risk of three complications of transfusion: HLA alloimmunization, cytomegalovirus transmission, and recurrent febrile nonhemolytic transfusion reactions. The application of the technology to all blood components does not appear to be warranted.
von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.

BACKGROUND Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome are severe microvascular disorders of platelet clumping with similar signs and symptoms. Unusually large multimers of von Willebrand factor, capable of agglutinating circulating platelets under high shear stress, occur in the two conditions. We investigated the prevalence of von Willebrand factor-cleaving protease deficiency in patients with familial and nonfamilial forms of these disorders. METHODS Plasma samples were obtained from 53 patients with thrombotic thrombocytopenic purpura or hemolytic-uremic syndrome. Von Willebrand factor-cleaving protease was assayed in diluted plasma samples with purified normal von Willebrand factor as the substrate. The extent of the degradation of von Willebrand factor was assessed by electrophoresis in sodium dodecyl sulfate-agarose gels and immunoblotting. To determine whether an inhibitor of von Willebrand factor-cleaving protease was present, we measured the protease activity in normal plasma after incubation with plasma from the patients. RESULTS We examined 30 patients with thrombotic thrombocytopenic purpura and 23 patients with the hemolytic-uremic syndrome. Of 24 patients with nonfamilial thrombotic thrombocytopenic purpura, 20 had severe and 4 had moderate protease deficiency during an acute event. An inhibitor found in 20 of these patients was shown to be IgG in five of five tested plasma samples. Of 13 patients with nonfamilial hemolytic-uremic syndrome, 11 had normal levels of activity of von Willebrand factor-cleaving protease during the acute episode, whereas in 2 patients, the activity was slightly decreased. All 6 patients with familial thrombotic thrombocytopenic purpura lacked von Willebrand factor-cleaving protease activity but had no inhibitor, whereas all 10 patients with familial hemolytic-uremic syndrome had normal protease activity. In vitro proteolytic degradation of von Willebrand factor by the protease was studied in 5 patients with familial and 7 patients with nonfamilial hemolytic-uremic syndrome and was normal in all 12 patients. CONCLUSIONS Nonfamilial thrombotic thrombocytopenic purpura is due to an inhibitor of von Willebrand factor-cleaving protease, whereas the familial form seems to be caused by a constitutional deficiency of the protease. Patients with the hemolyticuremic syndrome do not have a deficiency of von Willebrand factor-cleaving protease or a defect in von Willebrand factor that leads to its resistance to protease.
Technical‐Methodological Report: A Nomogram for Peak Leg Power Output in the Vertical Jump

Leg power is an important component in assessing both performance-related and health-related fitness. The Lewis equation and nomogram have been used for years to estimate leg power. A recent evaluation of the Lewis equation and further research led to the development of the Sayers equation. This equation provides an estimate of peak leg power, which has greater relevance than average power. Our purpose was to provide a simple and effective nomogram for calculating peak leg power output. The Sayers equation was transformed to an alignment nomogram and evaluated for facility of use and accuracy. The resultant alignment nomogram is easy to use and generates values for peak leg power in the vertical jump, which are well within the precision of the regression equation (r > 0.9999, CV < 0.2%). Interobserver error was less than 0.3% with a correlation of 0.9999. The Keir nomogram provides a simple and effective representation of the Sayers equation for use in both performance-related and health-related fitness assessments.
Is Product Innovation always Beneficial for Small and Medium Enterprises?

Currently, innovation is an important issue among SMEs, especially the creative industry. This research is based on the phenomenon that occurs in the creative (fashion) SMEs, such as batik, weaving, silver handicrafts and leather crafts industry that mostly traditionally produced in the Special Region of Yogyakarta, Indonesia. This study aims to examine the role of innovation in mediating the effect of market orientation and entrepreneur. It used a cross-sectional survey of 187 creative SMEs owners The data were analyzed with the analysis of structural equation modeling (SEM). Findings reveal that market orientation and entrepreneurial orientation proved to have a positive and significant effect on business performance. An interesting result of this study is that there are differences in measurement to construct market orientation variables in the context of SMEs. Other findings indicate that innovation plays a role as a mediator in the influence of market orientation and entrepreneurial orientation on SME business performance. Nevertheless, the mediating role of innovation in determining the magnitude of the influence between market orientation and entrepreneurial orientation on business performance is smaller than the direct influence. Overall, the results of this study indicate that a combination of market orientation and entrepreneurial orientation are the instruments that underlie fashion SMEs in shaping innovation to improve the performance of creative (fashion) SMEs. Keywords—Market orientation, Entrepreneurship orientation, Innovation, Business performance, SMEs.
Medicaid and the Supply of Entrepreneurs: Evidence from the Affordable Care Act

I examine whether the expansion of Medicaid eligibility under the Affordable Care Act increases the supply of entrepreneurs as measured by self-employment. Using the 2003–2017 Current Population Survey and focusing on childless adults in lowincome households, I apply difference-in-differences, propensity score weighting, and instrumental variable (IV) methods. I find that expanding Medicaid eligibility raises the self-employment rate by 0.8 to 1.6 percentage points, without increasing self-employment exit. IV estimates imply that covered individuals have 8 to 11 percentage points higher probability to become self-employed. Exploiting additional variation by spousal coverage or poor health of individuals or their spouse within triple difference specifications, I also find evidence that the underlying mechanism of the effect was through the reduction of entrepreneurship lock. The results suggest that limited access to health insurance may be a barrier to entrepreneurship. * PhD Candidate, George Mason University, Schar School of Policy and Government; klee17@gmu.edu. I am grateful to John Earle (Chair), Sita Slavov (Committee member), Len Nichols (Committee member), Thomas DeLeire (External reader) for guidance and support. I also thank Bo Cowgill, Chris Rider, Erik Gilje, Matt Marx, Rajshree Agarwal, and Sari Kerr for comments at the Kauffman Entrepreneurship Mentoring Workshop. The Ewing Marion Kauffman Foundation provided support for this research through the 2018 Kauffman Dissertation Fellowship program. The National Science Foundation also provided support for this research (Grant 1719201 to George Mason University).
Operations of Street Food Vendors and Their Impact on Sustainable Life in Rural Nigeria

In recent times, street food vending has become source of livelihood to some urban dwellers and has offered economic benefits to vendors and nutritious foods for the urban dwellers, especially in developing countries. The aim of this study is to investigate the operations and existence of street food vending in Nsukka urban area and examine its effects on sustainable life. Demographic profiles of vendors, their food safety knowledge, constraints in proper handling practices, the emergence of street food vending, its socioeconomic impact, nature and problems facing street food vendors and their impact on sustainable life were assessed using a closed ended questionnaire. It was found that street food vendors have existed in Nsukka urban area overtime and their emergence was consequent upon the quest for a better life. Also, street food vending has impacted positively on sustainable life in the area through being a source of employment and provision of essential services to the dwellers.
Pengaruh Trust dan Perceived Risk pada Intention To Use Menggunakan Technology Acceptance Model (Studi Kasus Pada Situs E-Commerce Traveloka)

Kemajuan Teknologi Informasi di Indonesia semakin memberikan dukungan dalam berbagai aktivitas dan kegiatan masyarakat, termasuk didalamnya memberikan kemudahan pada berbagai aspek kegiatan bisnis. Salah satu bisnis yang memanfaatkan Teknologi Informasi adalah penjualan tiket pesawat. Traveloka adalah salah satu situs E-Commerce layanan pencarian dan booking tiket pesawat online di Indonesia. Dalam penelitian ini, digunakan teori Technology Acceptance Model (TAM) dengan menambahkan dua extended variabel Trust dan Perceived Risk dengan tujuan mengetahui faktor-faktor apa saja yang berpengaruh signifikan terhadap adopsi Traveloka di Indonesia melalui Analisis Jalur dengan menggunakan software SPSS dan AMOS.
Efficacy of Splenectomy for Patients with Mantle Cell Non-Hodgkin's Lymphoma

The purpose of this study was to define the role of splenectomy in patients (pts) with mantle cell lymphoma (MCL) with regard to improving cytopenias and symptoms of splenomegaly. 26 pts with MCL underwent splenectomy between January 1987 and October 1999 and were followed prospectively for hematologic response and operative morbidity and mortality. A positive response was defined at 1 month of follow-up as: a hemoglobin of ≥11.0 g/dl in a pt with a preoperative value < 11.0 g/dl; or a platelet count of ≥ 100 × 109/L in a pt with a preoperative value < 100 × 109/L. A positive hematologic response was achieved in 69.2% of pts with preoperative anemia, 90% with thrombocytopenia, and 50% with both anemia and thrombocytopenia. The peri-and post-operative morbidity were 3.8 and 19.2%, respectively, the operative mortality was 0%. The median duration of hospitalization was six days. Four (15.4%) pts have not required chemotherapy after splenectomy. Three of these four were previously untreated and they have maintained stable disease for eight years after splenectomy without chemotherapy. Eight additional pts did not require chemotherapy for > 13 months after splenectomy. These results suggest that splenectomy may provide durable remission in selected pts with refractory cytopenias or symptoms related to splenomegaly in pts with MCL. There is a subset of pts that have prolonged disease stabilization without the requirement for immediate chemotherapy after splenectomy.
The concentration-dependent effect of progesterone on follicle growth in the mouse ovary

Follicle growth in the mammalian ovary is coordinately controlled by multiple factors to sustain periodic ovulation. In this study, we investigated the role of progesterone on follicle growth in the mouse ovary. As the concentration of progesterone changes during the estrus cycle, we cultured the sliced mouse ovary in a medium containing 10 ng/ml, 100 ng/ml, and 1 μg/ml progesterone. Progesterone promoted the growth of primordial to primary follicles at 100 ng/ml, while it suppressed the growth of secondary follicles at 1 μg/ml. Follicles at other developmental stages in the cultured ovary were unaffected with different concentrations of progesterone. The number of ovulated oocytes increased in the medium containing 100 ng/ml progesterone but decreased in the presence of 1 μg/ml progesterone. Follicles expressed two types of progesterone receptors, progesterone receptor (PGR) and PGR membrane component 1 (PGRMC1). While PGR shows transient expression on granulosa cells of Graafian follicles, PGRMC1 expresses in granulosa cells of developing follicles. These results suggest that progesterone controls the growth of developing follicles through PGRMC1. Our study shows that the effect of progesterone on ovulation and follicle growth in mouse ovary is dependent on the concentration of progesterone and the follicle stage.
Efficacy of Sodium Hypochlorite in Eradicating Hepatitis C Virus (HCV)-RNA from the Peritoneal Effluent of PD Patients

Hepatitis C virus (HCV) constitutes an important health problem among the population with chronic renal failure: in 15% – 20% according to various studies (1–8). Although different routes of transmission have been described, in an important number of patients the source of infection remains unknown. Peritoneal dialysis (PD) has been suggested as a better option than hemodialysis for dialysis in patients with HCV. Nevertheless, some 2% – 5% of patients treated with PD demonstrate serum antibodies against HCV. Although it is possible to find HCV in corporal fluids, even ascites (9), there are very few studies in PD patients on the risk of dissemination of HCV-RNA through the peritoneal effluent (10–15), and the conclusions of the aforementioned studies are contradictory. There are no published data on the eradication of HVC-RNA from the peritoneal effluent. Sodium hypochlorite is a low-cost disinfectant that is very effective against many bacteria and viruses. Numerous studies have tested its efficacy against viruses, including HCV, for avoiding transmission of HCV and human immunodeficiency virus (HIV) among intravenous drug users (16–18). However, there are no studies that demonstrate its efficacy in disinfecting PD bags of HCVpositive patients. The objective of this study was to evaluate the presence of HCV-RNA in peritoneal effluent and the efficacy of sodium hypochlorite in eliminating HCV-RNA.
Two different scenarios of squamous cell carcinoma within advanced Basal cell carcinomas: cases illustrating the importance of serial biopsy during vismodegib usage.

IMPORTANCE Vismodegib is a Hedgehog signaling pathway inhibitor recently approved by the US Food and Drug Administration for advanced basal cell carcinoma. We present 2 cases of clinically significant squamous cell carcinoma within the tumor bed of locally advanced basal cell carcinoma found during vismodegib treatment. OBSERVATIONS The first case is that of a patient with locally advanced basal cell carcinoma responsive to vismodegib but with an enlarging papule within the tumor bed. On biopsy, this papule was an invasive acantholytic squamous cell carcinoma. The second case is that of a patient with Gorlin syndrome with a locally advanced basal cell carcinoma that was stable while the patient was receiving therapy with vismodegib for 2.5 years but subsequently increased in size. Biopsy specimens from this tumor showed invasive squamous cell carcinoma, spindle cell subtype. In both cases, the squamous cell carcinomas were surgically resected. CONCLUSIONS AND RELEVANCE These cases highlight the importance of repeated biopsy in locally advanced basal cell carcinomas in 2 clinical situations: (1) when an area within the tumor responds differentially to vismodegib, and (2) when a tumor stops being suppressed by vismodegib. Timely diagnosis of non-basal cell histologic characteristics is critical to institution of effective therapy.
Emergency Ultrasound Identification of a Cornual Ectopic Pregnancy

CASE A 26-year-old female presented with complaints of vaginal bleeding. Her history was significant for fetal loss during her only prior pregnancy. Her last menstrual period was 6 weeks prior. The urine pregnancy test result was positive. She had visited an outside hospital the day before and was diagnosed with a threatened abortion. The patient reported that her ultrasound results at the time had revealed a ‘‘normal early pregnancy. ’’ Bedside transvaginal ultrasonography was performed (see video, online only) and a bicornuate uterus was identified. A pregnancy with gestational sac, yolk sac, and small fetal pole was identified high in the right cornual limb. The endo-myometrial mantle or EMM (the distance from the outer part of the gestational sac to the uterine wall) was found to be 5.6 mm. No free fluid was identified.
The role of satisfaction in fashion marketing: a meta-analysis

ABSTRACT We analysed the antecedents and consequents of satisfaction in the fashion industry. Due to the number of primary papers found in the systematic review with applications in different fashion contexts, we opted to analyse possible moderators. This meta-analysis was undertaken in three distinct steps: a data search, a data collection process and a process of data coding and analysis. We analysed studies published between 1993 and 2017. Thirty-seven studies were found to be valid with respect to this research. The studies generated 283 observations. Our results present a global synthesis of the antecedents and consequents of satisfaction in the fashion industry. Fifteen antecedents and 17 consequents were found to have a positive and significant effect size for the satisfaction construct in the fashion industry.