Miracle-dz/UniFAR-FTUs huggingface dataset:
The Benefits of Being Yourself: An Examination of Authenticity, Uniqueness, and Well-Being

In the United States, many people are instructed about the value of “being yourself ” from a young age. However, what evidence is there to support this notion and what happens when “being yourself ” causes a person to stand out, or be different, from others? The field of positive psychology, with its focus on the science behind well-being, stands well-positioned to answer these questions. By reviewing the theories, measurements, and research behind the two constructs of authenticity and uniqueness, this paper aims to show how being oneself does relate positively to well-being, even when doing so sets a person apart from others. It shows that humans have a desire to be authentic and doing so correlates with higher levels of life satisfaction and well-being. It also finds that humans have sometimes competing needs to belong and be unique but that these can be jointly fulfilled by joining distinctive groups. Data supports the connection between authenticity and well-being, as well as the human desire to stand out from others. Because of this, it seems that openness and acceptance must be encouraged on a broader scale in order for individuals and societies to flourish.
Prevalence of Barodontalgia among pilots and divers in Saudi Arabia and Kuwait

Barodontalgia is defined as tooth pain occurring with changes in pressure environment. It commonly affects pilots and divers, as they are frequently subjected to barometric pressure changes during their work. AIM: To measure the prevalence of barodontalgia among pilots flying non-commercial war planes and divers practicing in air bases, naval bases and diving schools in Saudi Arabia and Kuwait. MATERIAL AND METHODS: Three-hundred and fifty questionnaires consisting of demographic data and questions about the occurrence of tooth pain during flying or diving were distributed among pilots and divers. RESULTS: There was a response rate of 72.8% in Saudi Arabia and 80% in Kuwait. Almost thirty-four percent of the sample experienced barodontalgia at one point in time during their practice. More pilots had an occurrence of pain while flying (49.6%) than did divers while diving (17.3%). Pilots had higher incidence of pain while ascending (30.4%) than descending (19.3%), while divers had higher incidence of pain while diving (13.9%) than resurfacing to sea level (3.6%). The highest percentage of tooth pain occurred in pilots while flying at an altitude that ranged from 11,000 - 20,000 ft (3300 - 6000 m) and with divers while diving with a depth that ranged from 60 - 80 ft (18 – 24 m). Recurrence of tooth pain after treatment occurred in 16.4% of pilots and 25.0% of divers during their practice. CONCLUSIONS: Barodontalgia is common in Saudi Arabia and Kuwait with a prevalence rate as high as 33.6%. Pilots reported high occurrence than divers. It was common on ascent while flying and descent while diving. Recurrence of pain after treatment was not frequent.
Total knee arthroplasty after a previous patellectomy.

We performed a retrospective, matched-control analysis of the results of total knee arthroplasty with cement in twenty-two patients who had had a previous patellectomy for either a fracture of the patella (sixteen patients) or severe patellofemoral osteoarthrosis or chondromalacia patellae (six patients). Nine of the patients were men and thirteen were women. The average age at the time of the total knee arthroplasty was sixty-nine years (range, fifty-nine to seventy-four years). The average time from the patellectomy to the total knee arthroplasty was eight years (range, two to fourteen years). The patients were divided into two groups according to the type of implant that had been used. Group A (nine patients) had had insertion of a posterior stabilized prosthesis (a posterior cruciate-sacrificing implant) and Group B (thirteen patients) had had insertion of a posterior cruciate-sparing implant. Two computer-generated matched groups of patients who had had a total knee arthroplasty with insertion of implants that were identical to those in the study groups but who had not had a previous patellectomy served as controls. Group C consisted of patients who had had insertion of the same type of implant as that used in Group A, and Group D consisted of patients who had had insertion of the same type of implant as that used in Group B. All patients were evaluated before the arthroplasty and five years postoperatively with use of the rating system of the Knee Society. (ABSTRACT TRUNCATED AT 250 WORDS)
Depression, anxiety, and perceived hassles among entering medical students

Abstract This study investigated depression and anxiety among students who were entering medical school prior to the onset of their medical curriculum. Entering students reported financial, day-to-day, academic, and time hassles as concerns. Interestingly, the population characteristics of gender, marital status, and ethnicity impacted the type of self-reported hassles indicated by the students. Measurements of depression and anxiety indicated that entering medical school students' emotional status resembles that of the general population. The results suggest that it is the rigors of the medical curriculum that may play an important role in the increased prevalence of depression and anxiety for students during their medical education. Further, students who are entering medical field already have concerns about medical school and are in the process of anticipating the necessary adjustment to the challenges ahead of them. Preventative programming efforts should begin early in medical education and address a wide variety of concerns from academic, to interpersonal relationships and financial worries.
Phosphorylation of Cyclin D1 Regulated by ATM or ATR Controls Cell Cycle Progression

ABSTRACT Cyclin D1 is required at high levels for passage through G1 phase but must be reduced to low levels during S phase to avoid the inhibition of DNA synthesis. This suppression requires the phosphorylation of Thr286, which is induced directly by DNA synthesis. Because the checkpoint kinase ATR is activated by normal replication as well as by DNA damage, its potential role in regulating cyclin D1 phosphorylation was tested. We found that ATR, activated by either UV irradiation or the topoisomerase IIβ binding protein 1 activator, promoted cyclin D1 phosphorylation. Small interfering RNA against ATR inhibited UV-induced Thr286 phosphorylation, together with that seen in normally cycling cells, indicating that ATR regulates cyclin D1 phosphorylation in normal as well as stressed cells. Following double-stranded DNA (dsDNA) breakage, the related checkpoint kinase ATM was also able to promote the phosphorylation of cyclin D1 Thr286. The relationship between these checkpoint kinases and cyclin D1 was extended when we found that normal cell cycle blockage in G1 phase observed following dsDNA damage was efficiently overcome when exogenous cyclin D1 was expressed within the cells. These results indicate that checkpoint kinases play a critical role in regulating cell cycle progression in normal and stressed cells by directing the phosphorylation of cyclin D1.
Some Principles of Stratification: A Critical Analysis

T HE fact of social inequality in human society is marked by its ubiquity and its antiquity. Every known society, past and present, distributes its scarce and demanded goods and services unequally. And there are attached to the positions which command unequal amounts of such goods and services certain highly morallytoned evaluations of their importance for the society. The ubiquity and the antiquity of such inequality has given rise to the assumption that there must be something both inevitable and positively functional about such social arrangements. Clearly, the truth or falsity of such an assumption is a strategic question for any general theory of social organization. It is therefore most curious that the basic premises and implications of the assumption have only been most casually explored by American sociologists. The most systematic treatment is to be found in the well-known article by Kingsley Davis and Wilbert Moore, entitled "Some Principles of Stratification. " 1 More than
Negative-pressure ventilation improves cardiac output after right heart surgery.

BACKGROUND A low cardiac output state can complicate the postoperative course of patients undergoing Fontan-type operations and tetralogy of Fallot repair. METHODS AND RESULTS We investigated the effect of negative-pressure ventilation on cardiac output in 11 children in the early postoperative period after right heart surgery. All patients were initially ventilated with volume-cycled intermittent positive-pressure ventilation, and negative-pressure ventilation was delivered with the Hayek external high-frequency oscillator. Cardiac output was calculated by the direct Fick method, oxygen consumption being measured by respiratory mass spectrometry. Cardiac output was measured during intermittent positive-pressure ventilation and after 15 minutes of negative-pressure ventilation. Negative-pressure ventilation improved the cardiac output by a mean of 46% (P = .005). Heart rate did not change, and stroke volume increased by a mean of 48.5% (P = .005). Mixed venous saturation increased by 4.6% (P < .02), and consequently arteriovenous oxygen content difference fell significantly (P = .01). The systemic and pulmonary vascular resistances were reduced significantly during negative-pressure ventilation (P < .05 and P < .03, respectively). CONCLUSIONS Negative-pressure ventilation improves cardiac output in children after total cavopulmonary connection and tetralogy of Fallot repair and may prove to be an important therapeutic option in children with the low cardiac output state.
Breakdown strength measurements on cylindrical polyvinyl chloride sheaths under AC and DC voltages

In this work, we study the effect of the applied voltage form and its rise speed on breakdown voltage of polyvinyl chloride sheaths. We first present the statistical model of Weibull used for processing the results, then we describe the experimental devices. We finally study the evolution of the nominal breakdown voltage with 8 different rise ramps up to 4.75 kV.s-1 and under different forms (AC 50 Hz, positive and negative DC voltage). A population of 50 samples has been used for calculating the mean breakdown field at each profile voltage.
Structurally Distinct Ligand-Binding or Ligand-Independent Notch1 Mutants Are Leukemogenic but Affect Thymocyte Development, Apoptosis, and Metastasis Differently1

We previously found that provirus insertion in T cell tumors of mouse mammary tumor virus/c-myc transgenic (Tg) mice induced two forms of Notch1 mutations. Type I mutations generated two truncated molecules, one intracellular (IC) (Notch1IC) and one extracellular (Notch1EC), while in type II mutations Notch1 was deleted of its C terminus (Notch1ΔCT). We expressed these mutants in Tg mice using the CD4 promoter. Both Notch1IC and Notch1ΔCT, but not Notch1EC, Tg mice developed double-positive (DP) thymomas. These disseminated more frequently in Notch1ΔCT Tg mice. Double (Notch1IC × myc) or (Notch1ΔCT × myc) Tg mice developed thymoma with a much shorter latency than single Tg mice, providing genetic evidence of a collaboration between these two oncogenes. FACS analysis of preleukemic thymocytes did not reveal major T cell differentiation anomalies, except for a higher number of DP cells and an accumulation of TCRhighCD2highCD25high DP cells in Notch1IC, and less so in Notch1ΔCT Tg mice. This was associated with enhanced in vivo thymocyte proliferation. However, Notch1IC, but not Notch1ΔCT, DP thymocytes were protected against apoptosis induced in vivo by dexamethasone and anti-CD3 and in vitro by anti-CD3/CD28 Abs. This indicates that the C terminus of Notch1 and/or the conserved regulation by its ligands have a significant impact on the induced T cell phenotype. Therefore, Notch1IC and Notch1ΔCT behave as oncogenes for T cells. Because these two Notch1 mutations are very similar to those described in some forms of human T cell leukemia, these Tg mice may represent relevant models of these human leukemias.
Prolactin response to suckling and maintenance of postpartum amenorrhea among intensively breastfeeding Nepali women.

The aim of the study was to determine the association between PRL responses to suckling and maintenance of postpartum amenorrhea among breastfeeding mothers. Three blood spot samples (5, 30, and 50 min following a timed nursing bout) were collected from 71 intensively breastfeeding Nepali women for PRL determination. Maternal age, BMI (weight/height2), menstrual status, caste, infant age, nursing bout length, and duration of supplementation were recorded at time of sample collection. Independent and paired t tests, linear regression analyses, and general linear models were used to evaluate differences between cycling (n = 36) and amenorrheic (n = 35) women and associations among variables. Logistic regression analyses were used to relate PRL measures to the odds of maintaining lactational amenorrhea. Amenorrheic breastfeeding mothers had higher (P < .001) PRL levels at all 3 collection times than cycling breastfeeding mothers, and PRL levels declined with time since birth (P < 0.05). The odds (OR) of having ceased lactational amenorrhea was significantly higher (OR = 5.0, 95% Cl = 1.3-19.9) among mothers with lower PRL levels (< or = 10 ng/mL) at 50 min post-sucking, and PRL at 50 min showed a significant dose response relationship with menstrual status. The association between 50 min PRL levels and lactational amenorrhea appears to be independent of time postpartum, maternal age, BMI, nursing bout length, and duration of supplementation. Among intensively nursing women, maintenance of elevated PRL levels across the interbout interval increases the odds of maintaining lactational amenorrhea.
Modified Pressure Plate Apparatus and Column Testing Device for Measuring SWCC of Sand

The determination of soil-water characteristic curve (SWCC) is of major concern in unsaturated soil mechanics. For decades experimental and theoretical studies are performed to investigate the constitutive relationship between soil suction and volumetric water content. The major objective of our study is to generate an extensive experimental database for sand with a relevant suction range of just a few kPa. This database enables to derive conclusions on the sensitivity of hydraulic properties regarding different experimental procedures. Further, one objective is the comparison of results for SWCC derived from steady state and transient state tests. While the first type of tests considers equilibrium states, the subsequent test is related to non-equilibrium states. Experimental results are generated from a so called homogenous element test (modified pressure plate apparatus) and an initial boundary value experiment (column testing device) considering different hydraulic loading path directions. The experiments are analysed for sand with different initial states. Finally results are presented for SWCC including initial curves, main curves, and scanning paths. Discussion is focused on transient state versus steady state flow tests. No significant dynamic effects are observed for the sand studied. Results of well controlled element tests compare very well to initial boundary value experiments implying higher experimental efforts.
Abnormal fatty alcohol metabolism in cultured keratinocytes from patients with Sjögren-Larsson syndrome Published, JLR Papers in Press, October 30, 2007.

Sjögren-Larsson syndrome (SLS) is an inherited neurocutaneous disorder characterized by ichthyosis, mental retardation, spasticity, and deficient activity of fatty aldehyde dehydrogenase (FALDH). FALDH is an enzyme component of fatty alcohol:NAD oxidoreductase (FAO), which is necessary for fatty alcohol metabolism. To better understand the biochemical basis for the cutaneous symptoms in this disease, we investigated lipid metabolism in cultured keratinocytes from SLS patients. Enzyme activities of FALDH and FAO in SLS cells were <10% of normal. SLS keratinocytes accumulated 45-fold more fatty alcohol (hexadecanol, octadecanol, and octadecenol) than normal, whereas wax esters and 1-O-alkyl-2,3-diacylglycerols were increased by 5.6-fold and 7.5-fold, respectively. SLS keratinocytes showed a reduced incorporation of radioactive octadecanol into fatty acid (24% of normal) and triglyceride (13% of normal), but incorporation into wax esters and 1-O-alkyl-2,3-diacylglycerol was increased by 2.5-fold and 2.8-fold, respectively. Our results indicate that FALDH deficiency in SLS keratinocytes causes the accumulation and diversion of fatty alcohol into alternative biosynthetic pathways. The striking lipid abnormalities in cultured SLS keratinocytes are distinct from those seen in fibroblasts and may be related to the stratum corneum dysfunction and ichthyosis in SLS.
Single amino acid differences are sufficient for CD4(+) T-cell recognition of a heterologous virus by cattle persistently infected with bovine viral diarrhea virus.

Cattle that are persistently infected (PI) with one strain of bovine viral diarrhea virus (BVDV) can resolve infection with a second, antigenically heterologous strain but not the homologous strain. Since CD4(+) T cells are thought to be critical for the resolution of acute BVDV infection (Howard et al., 1992, Vet. Immunol. Immunopathol. 32, 303-314), we have examined the recognition of a heterologous virus (NADL) by CD4(+) T cells from Pe515-PI animals. The immune response of non-PI control cattle challenged with NADL or Pe515ncp was strain cross-reactive, whereas Pe515-PI animals responded to NADL only. The immune repertoire of both groups included NS3, which differs by approximately 1% (9/683) amino acids between these two viruses. Lymphoproliferative responses to proteins and synthetic peptides corresponding to three nonconservative differences in NS3 demonstrated that CD4(+) T cells from non-PI control animals responded well to proteins but poorly to the peptides from both viruses. In contrast, PI animals were responsive to heterologous proteins and peptides but nonresponsive to the homologous equivalents. A single amino acid difference between the two sequences was sufficient to allow responsiveness.
The Immune System and Responses to Cancer: Coordinated Evolution

This review explores the incessant evolutionary interaction and co-development between immune system evolution and somatic evolution, to put it into context with the short, over 60-year, detailed human study of this extraordinary protective system. Over millions of years, the evolutionary development of the immune system in most species has been continuously shaped by environmental interactions between microbes, and aberrant somatic cells, including malignant cells. Not only has evolution occurred in somatic cells to adapt to environmental pressures for survival purposes, but the immune system and its function has been successively shaped by those same evolving somatic cells and microorganisms through continuous adaptive symbiotic processes of progressive simultaneous immunological and somatic change to provide what we observe today. Indeed, the immune system as an environmental influence has also shaped somatic and microbial evolution. Although the immune system is tuned to primarily controlling microbiological challenges for combatting infection, it can also remove damaged and aberrant cells, including cancer cells to induce long-term cures. Our knowledge of how this occurs is just emerging. Here we consider the connections between immunity, infection and cancer, by searching back in time hundreds of millions of years to when multi-cellular organisms first began. We are gradually appreciating that the immune system has evolved into a truly brilliant and efficient protective mechanism, the importance of which we are just beginning to now comprehend. Understanding these aspects will likely lead to more effective cancer and other therapies.
Hereditary Frontotemporal Dementia Caused by Tau Gene Mutations

Tau protein is involved in microtubule assembly and stabilization. Filamentous deposits made of tau constitute a defining characteristic of several neurodegenerative diseases. The relevance of tau dysfunction for neurodegeneration has been clarified through the identification of mutations in the Tau gene in cases with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP‐17). Although the mechanisms by which these mutations lead to nerve cell death are only incompletely understood, it is clear that they cause the formation of tau filaments with distinct morphologies and isoform compositions. The range of tau pathology identified in FTDP‐17 recapitulates that in sporadic tauopathies, indicating a major role for tau dysfunction in these diseases.
Effects of fibronectin and other salivary macromolecules on the adherence of Escherichia coli to buccal epithelial cells

The effect of saliva and fibronectin (Fn) on the adherence of a type 1 fimbriated strain of Escherichia coli to human buccal epithelial cells was studied. Saliva pretreatment of epithelial cells led to a dose-dependent increase in adherence that was inhibited by alpha-methyl mannoside, which is typical of a type 1 fimbria-mediated event. The molecules responsible for affecting this increased adherence were nondialyzable and were recovered after lyophilization. E. coli adherence was stimulated by individual saliva samples from each of 11 volunteers. Fn inhibited E. coli adherence to saliva-treated buccal cells by more than 60%. Biotinylated E. coli and Fn were reacted with Western blots of whole saliva to identify the receptors that might explain the phenomenon described above. Both E. coli and Fn bound to 57- and 62-kilodalton (kDa) protein bands in Western blots of sodium dodecyl sulfate gels of whole saliva. The binding of E. coli to these bands was inhibited by pretreatment with unlabeled Fn. To study these salivary components, samples of saliva were electrophoresed on sodium dodecyl sulfate gels, strips corresponding to the appropriate molecular weights were cut out, and the proteins were eluted electrophoretically. Material that eluted from strips at 57 and 62 kDa, but not that from a control strip, stimulated E. coli adherence to buccal cells. Alternatively, saliva was fractionated over 100- and 50-kDa cutoff filters. Of the three fractions obtained, only the fraction passing through the 100-kDa filter and retained by the 50-kDa filter stimulated E. coli adherence to buccal cells. This fraction also increased the binding of Fn to buccal cells. These observations suggest the possibility that one or more salivary components bind to the surface of buccal cells and serve as receptors for type 1 fimbriated E. coli. Fn also binds to this isolated material; and it is apparently by these interactions, at least in part, that saliva stimulates and Fn inhibits E. coli adherence. The way in which these interactions may affect bacterial adherence in vivo remains to be elucidated.