Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypertension in Athletes

Regular physical activity and training are associated with reductions in blood pressure (BP), yet elevated BP is one of the most common abnormalities found during the pre‐participation physical evaluation of athletes. Hypertension (HTN) remains the most common cardiovascular condition encountered in athletic populations, therefore all athletes require screening for HTN. Because athletes often have white coat HTN, BP recordings outside the office are also necessary. The 36th Bethesda Conference classified sports according to their varying physiologic demands and provided specific recommendations for the evaluation, treatment, and sport participation of athletes with HTN. In general, angiotensin‐converting enzyme inhibitors and other vasodilators are the medications of choice for active and athletic patients because of their limited interference with cardiovascular conditioning. Other agents can be used but some sports governing bodies proscribe the use of certain antihypertensive medications such as β‐blockers for elite athletes.
Validation of GOMOS‐Envisat vertical profiles of O3, NO2, NO3, and aerosol extinction using balloon‐borne instruments and analysis of the retrievals

The UV-visible Global Ozone Monitoring by Occultation of Stars (GOMOS) instrument onboard Envisat performs nighttime measurements of ozone, NO 2 , NO 3 and of the aerosol extinction, using the stellar occultation method. We have conducted a validation exercise using various balloon-borne instruments in different geophysical conditions from 2002 to 2006, using GOMOS measurements performed with stars of different magnitudes. GOMOS and balloon-borne vertical columns in the middle stratosphere are in excellent agreement for ozone and NO 2 . Some discrepancies can appear between GOMOS and balloon-borne vertical profiles for the altitude and the amplitude of the concentration maximum. These discrepancies are randomly distributed, and no bias is detected. The accuracy of individual profiles in the middle stratosphere is 10 % for ozone and 25 % for NO 2 . On the other hand, the GOMOS NO 3 retrieval is difficult and no direct validation can be conducted. The GOMOS aerosol content is also well estimated, but the wavelength dependence can be better estimated if the aerosol retrieval is performed only in the visible domain. We can conclude that the GOMOS operational retrieval algorithm works well and that GOMOS has fully respected its primary objective for the study of the trends of species in the middle stratosphere, using the profiles in a statistical manner. Some individual profiles can be partly inaccurate, in particular in the lower stratosphere. Improvements could be obtained by reprocessing some GOMOS transmissions in case of specific studies in the middle and lower stratosphere when using the individual profiles.
High production of a class III lantipeptide AmfS in Streptomyces griseus

AmfS, a class III lantipeptide serves as a morphogen in Streptomyces griseus. Here, we constructed a high production system of AmfS in S. griseus. We isolated S. griseus Grd1 strain defective in glucose repression of aerial mycelium formation and found it suitable for the overproduction of AmfS. Two expression vectors carrying the strong and constitutive ermE2 promoter were constructed using a multicopy number plasmid, pIJ702. The use of the Grd1 strain combined with the expression vectors enabled high production of AmfS by S. griseus into its culture broth. The expression system was also effective for the generation of abundant AmfS derived from Streptomyces avermitilis. In addition, site-directed mutagenesis revealed the amino acid residues essential for the morphogen activity of AmfS. These results indicate that the constructed system enables efficient production of class III lantipeptides by Streptomyces. Graphical abstract High production of a class III lantipeptide AmfS in Streptomyces griseus.
Magnetic-Field Induced Isotropic to Nematic Phase Transition in Ferronematics

In this work the thermotropic liquid crystal 4-(trans-4'-n-hexylcyclohexyl)-isothiocyanato-benzene (6CHBT) was doped with differently shaped magnetic nanoparticles with the aim to increase the sensitivity of the liquid crystal on the external magnetic field. The volume concentration of the magnetic particles was 2×10-4. The phase transition temperature from isotropic to nematic phase in external magnetic fields up to 12 T was monitored by precise capacitance measurements in capacitance cells filled with the prepared ferronematic samples. The shift in the temperature from isotropic to nematic phase was observed in the liquid crystal doped with rodlike particles. To our knowledge, this is the first observation of such a magnetic-field induced transition in ferronematics based on a calamitic liquid crystal.
Temporal and spatial changes in the diet of Hyla pulchella (Anura, Hylidae) in southern Uruguay

In this article we report the diet of a population of the hylid frog Hyla pulchella from southeastern Uruguay. We collected the specimens in ponds, where we identified microenvironments defined by the invertebrate assemblage, during one year divided into two seasons (warm and cold). We taxonomically determined 10365 invertebrates belonging to 21 categories in the digestive tracts of frogs. We estimated the diversity of the diet and alimentary preference according to microenvironments and seasons. We estimated the expected richness of both diet and prey availability using a null model based on the hypergeometric distribution. We performed Discriminant Analyses and Kruskal-Wallis tests to detect changes in prey availability among microenvironments and between seasons. The overall diet in terms of frequencies was composed primarily of arthropods (mainly Araneae, Diptera, Hymenoptera, and Coleoptera) and in terms of volume, by larvae. The most relevant items to study the microenvironmental and seasonal variation in the available preys were Araneae, Collembola, Homoptera, Hymenoptera, Diptera, Dictioptera, Lepidoptera, Coleoptera, and larvae. Based on the null model curves and preference indexes we inferred positive selection by larvae, Isopoda, Dictioptera, Lepidoptera, and Diptera, and negative selection by Collembola and Hymenoptera. The diversity of diet and the null model curves indicated that the diet changes among microenvironments and seasons. This frog may be considered as a middle generalist predator, with some selective behavior and a combined search strategy (active and sit-and-wait). We conclude that the knowledge about the availability of preys is a relevant tool for trophic studies.
Knowledge of HIV Postexposure Prophylaxis in a Population of HIV-Positive Outpatients: Results of a French National Survey

Abstract:Since 1998, French HIV guidelines have recommended use of HIV prophylaxis after unprotected sex (postexposure prophylaxis, or PEP) with an HIV-positive partner. To characterize factors associated with lack of PEP knowledge in an HIV-positive population, a cross-sectional survey was conducted of 737 French HIV-positive outpatients followed in AIDS care units of 2 regions accounting for 60% of French AIDS cases. Information was collected through face-to-face interviews. The sample was weighted to improve national validity. Median age was 41 years, 73.2% of patients were male, and 8.5% reported HIV-related risk behaviors. Those who knew about PEP and those who did not were compared with χ2 tests and logistic regression. One third of the sample had never heard of PEP. In multivariate analysis, lack of PEP knowledge was associated with older age, low educational level, unstable housing, unawareness of current HIV laboratory data, and lack of ability to confide in nurse and to seek out information from various sources. The increased number of people living with HIV infection as a chronic disease raises new challenges for its secondary prevention. Preventive programs aimed at HIV-positive individuals and their sexual partners are strongly needed.
Taking a hard look at the Heart Truth campaign in Canada: A discourse analysis

The Canadian Heart and Stroke Foundation launched the Heart Truth campaign to increase women’s awareness of heart disease. However, little is known about how such campaigns intersect with broader understandings of gender and health. This discourse analysis examined the construction of gender, risk, and prevention within campaign material. Two primary discourses emerged: one of acceptable femininity, which outlines whose risk, survivorship, and prevention matters, and another of selfless prevention. Women of diverse ethnic, sexual, and socio-economic background were largely absent. Prevention was portrayed as a personal choice, eclipsing conversations about social determinants of health and the socio-political context of heart disease.
Self-Transcendence and Family Caregivers of Adults with Dementia

Research has documented that caring for a family member with dementia is stressful and burdensome. However, difficult life experiences such as fear, loss, and grief may help persons move beyond a concern for self toward a larger perspective and concern for others. Both positive and negative experiences can promote positive movement toward growth and development. This movement has been described as self-transcendence, or the ability to look beyond the self and present difficulties, to extend concern to others, and to find personal meaning and wholeness in the context of life-changing events. The family caregiving experience with its inherent difficulties might provide the impetus for such a movement toward self-transcendence. The purpose of this article is to examine the concept of self-transcendence, explore its linkages to the caregiving experience, and suggest potential strategies to assist family caregivers to achieve self-transcendence.
Evaluation of a frost accumulation model

Formation of frost on paved surfaces presents a potential hazard to the motoring public in cold climates. Temperatures of the paved surface are not measured routinely by the National Weather Service and are not part of public forecasts of winter conditions, yet highway maintenance personnel must make frost suppression and anti‐icing decisions based on expectations of future paved‐surface temperatures. The Road Weather Information System measures road surface, air and dew‐point temperatures, road surface conditions, and wind data at numerous locations in the state of Iowa and reports the data in real‐time to maintenance offices. A model based on simple concepts of moisture flux to the surface was developed that uses data from roadway weather stations or forecasts of dew‐point temperature, air temperature, surface temperature and wind speed to calculate frost accumulation on bridge decks in Iowa. The analysis showed that the model has sufficient accuracy to be used as an operational tool for assessing frost accumulation on bridge decks. A logistical regression procedure was developed to determine the probability that a maintenance worker will observe frost for a given calculated frost depth. Copyright © 2003 Royal Meteorological Society.
Hypoxia tolerance in mammalian heterotherms

SUMMARY Heterothermic mammals tolerate severe hypoxia, as well as a variety of central nervous system insults, better than homeothermic mammals. Tolerance to hypoxia may stem from adaptations associated with the ability to survive hibernation and periodic arousal thermogenesis. Here, we review evidence and mechanisms of hypoxia tolerance during hibernation, euthermy and arousal in heterothermic mammals and consider potential mechanisms for regenerative-like processes, such as synaptogenesis, observed within hours of hypoxic stress associated with arousal thermogenesis.
Treatment of young children with CNS‐positive acute lymphoblastic leukemia without cranial radiotherapy

Due to the long‐term sequelae of cranial radiotherapy (CRT), contemporary treatment protocols for children with acute lymphoblastic leukemia (ALL) aim to limit the use of prophylactic CRT. For patients with central nervous system (CNS) involvement with ALL at diagnosis, the use of CRT remains common. Children <5 years of age are a particularly challenging subgroup in whom the consequences of CRT can be devastating.
Acyclovir prophylaxis for herpes simplex virus infection

ACV is an effective agent for the treatment and prophylaxis of HSV infections in both IC and immunologically normal individuals. The drug is well tolerated in both populations and is not significantly associated with clinical or laboratory toxicities. Because of the great potential benefit and low risk, organ transplant recipients and patients with hematologic malignancies undergoing induction chemotherapy should be screened routinely for HSV antibodies; seropositive individuals should receive prophylactic ACV during the period of most profound immunosuppression. Immunologically normal individuals with frequently recurring genital HSV or serious complications associated with outbreaks are candidates for long-term suppression with ACV.
Initial Validation of Novel Performance-Based Measures: Mental Rotation and Psychomotor Ability

Abstract : Given the high-risk nature of military flight operations and the significant resources required to train U.S. Naval Aviators and Flight Officers, personnel selection must continually be improved. In addition to general commissioning requirements and aeromedical standards, the U.S. Navy utilizes the Aviation Selection Test Battery (ASTB) to select commissioned aviation students. Although the ASTB has historically proven to be a good predictor of aviation student performance in training, it is proposed here that incremental improvement may be gained with the introduction of novel, computer administered performance-based measures: the Block Rotation Task (BRT) and a Navy-developed 2-D compensatory tracking task. This work constituted an initial validation of the two tasks. The BRT is an interactive virtual analog of Shepard-Metzler's (1971) mental rotation task. The 2-D tracking task is typical of what is found in the literature, but was developed by the U.S. Navy. The BRT was investigated for its suitability as a measure for quantifying both mental rotation and psychomotor ability. Data from the BRT were examined to determine task reliability and to formulate a quantitative/predictive performance model of combined human mental rotation and psychomotor ability. Data gathered from the compensatory tracking task were investigated to determine if they concord with results in extant literature, indicating the validity of the task. Results showed that both the BRT and the 2-D tracking tasks are measures of spatial ability. A descriptive performance model of the BRT is also presented.
A randomized trial comparing lithoclast with an electrokinetic lithotripter in the management of ureteric stones

ObjectiveTo compare two in situ ballistic lithotripters, the lithoclast and the electrokinetic lithotripter (EKL), both of which can be used through the newer small‐bore ureteroscopes, for their ease of use, robustness, fragmentation time, adequacy of fragmentation and stone‐free rate.
Cross-Sectional Asset Pricing Tests

A major problem in finance is to understand why different financial assets earn vastly different returns on average. In this paper, we survey various econometric approaches that have been developed to empirically examine various asset pricing models used to explain the difference in cross section of security returns. The approaches range from regressions to the generalized method of moments, and the associated asset pricing models are both conditional and unconditional. In addition, we review some of the major empirical studies.
Characterization of Anticancer Principles of Celosia argentea (Amaranthaceae)

Background: An Indian origin, Celosia argentea is a weed growing during rainy season traditionally claimed for treating several ailments. Early researches on C. argentea were focused on the anti-cancer screening of seeds, with few reports on aerial parts. Objective: To isolate and characterize bioactive compounds of aerial parts of C. argentea and evaluate their anticancer potential. Materials and Methods: The methanolic aerial part extract was fractionated on column chromatography using chloroform: methanol mixture. The fractions; 80:20 and 95:5 were purified on MCI-HP20 HPLC column. Chromatographically pure compounds were pooled, concentrated and characterized spectroscopically. The compounds were further screened for anti-oxidant and cytotoxic potential. Results: Isolated compounds were confirmed as: (1) Luteolin-7-O-glucoside and (2) phenolic, 1-(4-hydroxy-2-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione. Both exhibited significant antioxidant potential with IC50values of 20.80 and 21.30 μg/ml for 2,2-diphenyl-1-picrylhydrazyl assay (***P < 0.001) and significant Trolox equivalent antioxidant capacity (TEAC) values for 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (*P < 0.05) and ferric reducing antioxidant potential assay (****P < 0.0001). In 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide assay, Compound 1 and 2 showed potent cytotoxicity against SiHa, HCT, MCF-7 cancer cell lines at 20 μg/ml (****P < 0.0001) and 18 μg/ml (**P < 0.01), respectively, without affecting the normal Vero cells. Both compounds enabled maximum reduction in cell viability at 50 μg/ml against HT-29 (***P < 0.001) and MCF-7 cell lines (**P < 0.01) in try pan blue viability assay. Apoptosis occurred at concentrations of 47.33 ± 0.8 μg/ml and 56.28 ± 1.2 μg/ml for Compound 1 and 35.15 ± 0.4 μg/ml and 28.05 ± 0.3 μg/ml for Compound 2 for HT-29 and MCF-7 respectively. Conclusion: A novel anticancer phenolic compound; (1-(4-hydroxy-2-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione), isolated from aerial parts of C. argentea was a valuable finding of the research.
Current therapeutic approaches for patients with myelodysplastic syndromes

The myelodysplastic syndromes (MDS) are a heterogeneous spectrum of disorders requiring selective therapy based on patients’ specific clinical features, predominantly their prognostic subgroups, age and performance status. Guidelines for management of patients with MDS have been generated by a number of national panels. This review focuses on evidence‐based data supporting therapeutic approaches, which have also been recommended by the US National Comprehensive Cancer Network MDS Panel, with discussion of accessibility of recommended drugs in the US and in other countries. For lower risk disease (International Prognostic Scoring System Low and Intermediate‐1) therapy is aimed at haematological improvement whereas for higher risk disease (Intermediate‐2 and High) treatment focuses on altering disease natural history. Recent information regarding additional clinical and biological features has provided useful parameters for assessing disease prognosis that aid risk‐based management decisions. The rationale for use of low versus high intensity therapies with these agents, including allogeneic haematopoietic stem cell transplantation, is discussed in detail.
Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2High receptor

The glutamate agonist LY404,039 has been used to treat schizophrenia. Because all currently used antipsychotics act on dopamine receptors, it was decided to examine whether this glutamate agonist also had an affinity for dopamine D2 receptors in vitro. The present data show that LY404,039 inhibited the binding of [3H]domperidone and [3H](+)PHNO by 15.5 ± 1.5% to the high‐affinity state, D2High, of cloned dopamine D2Long receptors and rat striatal tissue with dissociation constants of between 8.2 and 12.6 nM. This high‐affinity component of LY404,039 on the binding of [3H]domperidone was inhibited by the presence of guanine nucleotide, indicating an agonist action of the drug at D2High. LY404,039 also stimulated the incorporation of [35S]GTP‐γ‐S into D2Long receptors (EC50% = 80 ± 15 nM) over the same range of concentrations as occurred for the inhibition of [3H]domperidone by LY404,039 at D2High (IC50%High = 50 ± 10 nM). A possible clinical antipsychotic action of LY404,039 may depend on the combined stimulation of glutamate receptors and a partial dopamine agonist action that would interfere with neurotransmission at D2High receptors. Synapse 63:935–939, 2009. © 2009 Wiley‐Liss, Inc.
TransForm occlusion balloon catheter for the treatment of intracranial aneurysms, initial experience

Introduction The technique of balloon remodeling allows the endovascular treatment of wide-neck intracranial aneurysms. For many years the only available devices were the Hyperform and the Hyperglide balloon catheters. Recently, other companies have developed newer devices, single or dual-lumen. We present our initial experience with the TransForm occlusion balloon catheter for the treatment of intracranial aneurysms. Methods We retrospectively analysed from our prospectively gathered aneurysm database all aneurysms that were treated with balloon remodelling using TransForm occlusion balloon catheters from January 2013 to February 2014. We assessed patient demographics, morphological features of the aneurysms, procedure feasibility, technical and clinical complications. Results Thirty-three patients harbouring 36 intracranial saccular aneurysms were treated during 33 procedures. Clinical finding were: 15 incidental discovery, 13 subarachnoid haemorrhage (SAH), five aneurysms with mass effect, one ruptured aneurysm with SAH and mass effect, one recanalisation and one intraparenchymal haematoma. Thirty-five aneurysms were in the anterior and one in the posterior circulation. Mean dome and neck size were, respectively, 5.8 mm and 3.6 mm. Twenty-three aneurysms were treated with TransForm C and 13 with TransForm SC. We had two procedural thromboembolic complications, without permanent clinical events. No early rebleeding occurred. Conclusions In our small series, the TransForm occlusion balloon catheter seems to be safe and effective for the treatment of intracranial aneurysms, in ruptured and unruptured cases.
Vp1659 Is a Vibrio parahaemolyticus Type III Secretion System 1 Protein That Contributes to Translocation of Effector Proteins Needed To Induce Cytolysis, Autophagy, and Disruption of Actin Structure in HeLa Cells

ABSTRACT Vibrio parahaemolyticus harbors two type III secretion systems (T3SSs; T3SS1 and T3SS2), of which T3SS1 is involved in host cell cytotoxicity. T3SS1 expression is positively regulated by ExsA, and it is negatively regulated by ExsD. We compared the secretion profiles of a wild-type strain (NY-4) of V. parahaemolyticus with those of an ExsD deletion mutant (ΔexsD) and with a strain of NY-4 that overexpresses T3SS1 (NY-4:pexsA). From this comparison, we detected a previously uncharacterized protein, Vp1659, which shares some sequence homology with LcrV from Yersinia. We show that vp1659 expression is positively regulated by ExsA and is negatively regulated by ExsD. Vp1659 is specifically secreted by T3SS1 of V. parahaemolyticus, and Vp1659 is not required for the successful extracellular secretion of another T3SS1 protein, Vp1656. Mechanical fractionation showed that Vp1659 is translocated into HeLa cells in a T3SS1-dependent manner and that deletion of Vp1659 does not prevent VopS from being translocated into HeLa cells during infection. Deletion of vp1659 significantly reduces cytotoxicity when HeLa cells are infected by V. parahaemolyticus, while complementation of the Δvp1659 strain restores cytotoxicity. Differential staining showed that Vp1659 is required to induce membrane permeability in HeLa cells. We also show evidence that Vp1659 is required for actin rearrangement and the induction of autophagy. On the basis of these data, we conclude that Vp1659 is a T3SS1-associated protein that is a component of the secretion apparatus and that it is necessary for the efficient translocation of effector proteins into epithelial cells.