Miracle-dz/UniFAR-FTUs huggingface dataset:
IL-17 A enhance the effectiveness of IFN-α to regulated miR-23 b in HepG 2 . 2 . 15 cells

Hepatitis B virus (HBV) mainly damage liver cells through immune response. The purpose of this study was to determine whether the expression of MicroRNAs-23b (miR-23b) would be regulated by interferon-α and judge the value to antiviral treatment. Line of Hepa2.2. 15 cells were cultured with interleukin-17A (IL-17A), tumor growth factor-β1 (TFG-β1) and interferon-α (INF-α), detect the expression of miR-23b in culture solution. We found when co-cultured with IL-17A and interferon-α, the duration of miR-23b peak concentration was pro-longed significantly in cell culture medium. In Conclusion, this study showed that INF-α can up-regulate the expression of miR-23b, IL-17A and TGF-β1 would enhance the effectiveness.
Role of EPS , dispersant and nutrients in marine oil snow formation in surface waters of the subarctic Faroe-Shetland Channel and the associated microbial response

Copyright statement: © 2017 Duran_suja, Summers and Gutierrez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The accuracy of various activity trackers in estimating steps taken and energy expenditure

Purpose: Activity monitors are designed for helping to monitor the quantity and intensity of exercise training. While there is a reasonable experience with step counters, there are a rapidly expanding number of devices available on the marketplace, many purporting to be able to accurately measure energy expenditure (EE). This study was designed to test the accuracy of step count and energy expenditure in several commercially available activity monitors. Methods: Healthy, physically-active volunteers (N=20) performed treadmill walking, treadmill running, elliptical (arm + leg) exercise and an agility drill that included some basketball actions while wearing step counters/activity monitors (Jawbone UP, Nike Fuelband, Fitbit Ultra, NL-2000i, Adidas MiCoach, Body Media FIT Core). Criterion step counts were measured by direct visual observation and EE was measured by a portable metabolic system. Results: During normal ambulation and elliptical exercise, most of the measured step counts were reasonably accurate (+10% of the criterion measure). During the agility drills, the errors in step counts were systematically less than the criterion measure. Although some of the devices were reasonably accurate for measuring EE during normal ambulation, the errors in measuring EE were, in general, unacceptably large and became larger with non-standard ambulation. However, measured across the entire range of activities, both step counts and EE were broadly accurate if not precise. Conclusions: The results suggest that step count accuracy during normal ambulation can be measured accurately by a number of devices. However, during non-standard ambulation (particularly for measurement of EE), these contemporary activity monitoring devices require improved algorithms. ; ;
RAL-TR-2004-009 A filter-trust-region method for unconstrained optimization

A new filter-trust-region algorithm for solving unconstrained nonlinear optimization problems is introduced. Based on the filter technique introduced by Fletcher and Leyffer, it extends an existing technique of Gould, Leyffer and Toint (SIAM J. Optim., to appear, 2004) for nonlinear equations and nonlinear least-squares to the fully general unconstrained optimization problem. The new algorithm is shown to be globally convergent to at least one second-order critical point, and numerical experiments indicate that it is very competitive with more classical trust-region algorithms. 1 Computational Science and Engineering Department, Rutherford Appleton Laboratory, Chilton, Oxfordshire, OX11 0QX, England, UK. Email: n.gould@rl.ac. uk 2 Current reports available from “http://www.numerical. rl.ac. uk/reports/reports.shtml”. 3 This work was supported by the EPSRC grant GR/S42170 4 Department of Mathematics, Facultés Universitaires ND de la Paix, 61, rue de Bruxelles, B-5000 Namur, Belgium, EU. Email : caroline.sainvitu@math.fundp.ac.be & philippe.toint@fundp.ac.be 5 Current reports available from “http://www.fundp.ac.be/∼phtoint/pht/publications.html”. Computational Science and Engineering Department Atlas Centre Rutherford Appleton Laboratory Oxfordshire OX11 0QX March 8, 2004. A filter-trust-region method for unconstrained optimization 1
All you need is trade : On the in ( ter ) dependence of trade and asset holdings in gravity equations

This paper looks at the interrelationship between trade in goods and asset holdings, as brought forward by some contributions to the empirical literature in international economics. These contributions argue that single-equation gravity models suffer from an endogeneity bias, culminating in a request for the estimation of systems of gravity equations. Yet, the theoretical basis for such an interrelationship is weak. In this paper we present baseline models of international trade in goods and bank asset holdings, which yield gravity equations that can be tested empirically. We then use these models to test three different explanations for the interrelationship between trade in goods and asset holdings that have been brought forward by the literature: (i) consumption hedging, (ii) sovereign risk, (iii) information spillovers. Our results indicate that none of these channels can explain the interrelationship. We therefore conclude that single-equation gravity models, as opposed to systems of gravity equations, are justified: All you need is
The serotonin-dopamine interaction measured with positron emission tomography (PET) and C-11 raclopride in normal human subjects

Our previous studies have shown that the interaction between serotonin and dopamine can be measured with C-11 raclopride and PET in the baboon brain. A series of studies was undertaken to extend dim findings to the normal human brain. PET studies were conducted in male control subjects (n=8) using the CTI 931 tomograph. Two C-11 raclopride scans were performed, prior to and 180 minutes following administration of the selective serotonin releasing agent, fenfluramine (60mg/PO). The neuroendocrine response to fenfluramine challenge is commonly used in psychiatric research as an index of serotonin activity. The C-11 raclopride data were analyzed with the distribution volume method. For the group of subjects, an increase was observed in the striatum to cerebellum ratio (specific to non-specific binding ratio), in excess of the test-retest variability of the ligand. Variability in response was observed across subjects. These results are consistent with our previous findings in the baboon that citalopram administration increased C-11 raclopride binding, consistent with a decrease in endogenous dopamine. In vivo microdialysis studies in freely moving rats confirmed that citalopram produces a time-dependent decrease in extracellular dopamine levels, consistent with the PET results. In vivo PET studies of the serotonin-dopamine interaction are relevant to themore » evaluation of etiologic and therapeutic mechanisms in schizophrenia and affective disorder. « less
The Devil is in the Details: A Magnifying Glass for the GuessWhich Visual Dialogue Game

Grounded conversational agents are a fascinating research line on which important progress has beenmade lately thanks to the development of neural network models and to the release of visual dialogue datasets. The latter have been used to set visual dialogue games which are an interesting test bed to evaluate conversational agents. Researchers’ attention is on building models of increasing complexity, trained with computationally costly machine learning paradigms that lead to higher task success scores. In this paper, we take a step back: We use a rather simple neural network architecture and we scrutinize theGuessWhich task, the dataset, and the quality of the generated dialogues. We show that our simple Questioner agent reaches state-of-the art performance, that the evaluation metric commonly used is too coarse to compare different models, and that high task success does not correspond to high quality of the dialogues. Our work shows the importance of running detailed analyses of the results to spot possible models’ weaknesses rather than aiming to outperform state-of-the-art scores.
Human Immunodeficiency Virus Drug Resistance : 2018 Recommendations of the International Antiviral Society –

Huldrych F. Günthard, Vincent Calvez, Roger Paredes, Deenan Pillay, Robert W. Shafer, Annemarie M. Wensing, Donna M. Jacobsen, and Douglas D. Richman University Hospital Zürich and Institute of Medical Virology, University of Zurich, Switzerland; Pierre et Marie Curie University and Pitié-Salpêtrieŕe Hospital, Paris, France; Infectious Diseases Service and IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Spain; Africa Health Research Institute, KwaZulu Natal, South Africa; University College London, United Kingdom; Stanford University Medical School, California; University Medical Center Utrecht, The Netherlands; and International Antiviral Society–USA, San Francisco, and Veterans Affairs San Diego Healthcare System and University of California San Diego
Financial Intermediaries as Facilitators of Reputation Formation in Credit Markets

This paper identi es a new role for nancial intermediaries. The basic premise is that the smooth ow of information is obstructed when the number of lenders becomes too large. This erodes the value of a good credit history, which encourages default and may restrict lending. Financial intermediation gets around this di¢ culty by separating the identity of capital ownership from the identity of lenders. Since each intermediary represents a very large number of capital owners, the number of direct lenders (the intermediaries) can be kept small enough to facilitate the smooth ow of information between lenders even when the number of indirect lenders (depositors) is very large. This restores borrowers incentives for reputation formation and hence lendersincentives to lend. JEL Classi cation Numbers: G2, D82
Neurologic complications in organ transplant recipients

Heart and Lung, and Combined Heart-Lung Transplantation Liver Transplantation Kidney and Pancreas Transplantation Bone Marrow(Hematopoietic Cell) Transplantation Neurologic Complications in Transplant Recipients: A Bird's Eye View Failure to Awaken and Acute Disturbances of Consciousness Psychiatric Complications of Organ Transplantation Seizures Neurologic Manifestations of Immunosuppressive Agents Central Nervous System Infections Neuromuscular Disorders Cerebrospinal Disorders De Novo Malignant Lesions of the Central Nervous System Demyelinating Disorders
Transcriptome analysis for novel peptide in breeding gland of Hymenochirus boettgeri

By Minjin Ko University of the Pacific 2019 The primary goal of the project was to find nucleotide sequences potentially encoding a pheromone from the breeding gland of Hymenochirus boettgeri. The reasons in searching for the sequence of a pheromone were to better understand the organism and to use the information for application in reproduction of other species. Due to climate change and rampant deforestation, such as in Africa’s Congo Basin, many amphibian species are being threatened. With these increasing threats, a viable option for the future may be breeding in captivity for the amphibian species. Pheromone characterization from the breeding gland of Hymenochirus boettgeri may help with better understanding of reproduction in other species. Overall, five candidate signaling peptides that have the potential to be a pheromone from the breeding gland were found with transcriptome assembly and annotation of the breeding gland. The project focused on obtaining transcriptome data for the breeding gland by 1) RNA sequencing 2) de novo transcriptome assembly and 3) transcriptome annotation. The transcriptome of the breeding gland is now available for future proteomic studies.
Improving Palliative Care for Cancer

In our societya (TM)s aggressive pursuit of cures for cancer, we have neglected symptom control and comfort care. Less than one percent of the National Cancer Institutea (TM)s budget is spent on any aspect of palliative care research or education, despite the half million people who die of cancer each year and the larger number living with cancer and its symptoms. Improving Palliative Care for Cancer examines the barriersa "scientific, policy, and sociala "that keep those in need from getting good palliative care. It goes on to recommend public- and private-sector actions that would lead to the development of more effective palliative interventions; better information about currently used interventions; and greater knowledge about, and access to, palliative care for all those with cancer who would benefit from it.
Relationship of Perceived Family Social Support and DepressionSymtomps of Old People Living in Alanlý District, Samsun -

ÖZET AMAÇ: Bu çalışma, kendi evinde yaşayan yaşlı bireylerin algıladıkları sosyal destek faktörlerini, depresif belirti sıklığını araştırmak ve sosyal destek ile depresif belirti sıklığı arasındaki ilişkiyi ortaya koymak amacıyla yapılmıştır YÖNTEM: Araştırma tanımlayıcı nitelikte bir çalışmadır. Veriler 1 Şubat20 Mayıs 2007 tarihleri arasında toplanmıştır. Bu çalışma Samsun il merkezinde bulunan Alanlı Köyünde ailesiyle ya da yalnız yaşayan 65 ve üzeri yaştaki bireylerle yapılmıştır. Çalışma grubu kendi evinde yaşayan 62 bireyden oluşmuştur. Veriler üç ayrı form kullanılarak elde edilmiştir: 1. Sosyo-Demografik Bilgi Formu, 2. Çok Boyutlu Algılanan Sosyal Destek Ölçeği, 3. Geriatrik Depresyon Ölçeği. Verilerin değerlendirilmesinde tanımlayıcı istatistiklerle birlikte, normal dağılım gösteren veriler için t testi ve korelasyon analizi, normal dağılım göstermeyen verilerde ise Mann Whitney U (U) ve Kruskall Wallis (KW) testleri kullanılmıştır. BULGULAR: Yaşlıların yaş ortalamaları 71,74±5,72 yıldır. Yaşlıların % 48,4’sı erkek, %51,6’sı kadındır. Çalışmada Samsunda kendi evlerinde aileleriyle veya yalnız başlarına yaşayan 65 yaş üzeri bireyler geriatrik depresyon ölçeği (GDÖ) ve algılanan aile desteği ölçeği ile tarandı. Yaşlıların GDÖ'nden aldıkları ortalama puan 11,09± 6. ,20 idi. Yaşlıların günlük işlerini yapabilme ve sigara içme durumları ile depresyon durumları arasında ilişki saptanmıştır. Evde yaşayanların yaşlıların “%37,1’inde eşik üstü depresif belirti sıklığı saptanmış ve depresyonla algılanan sosyal destek arasında anlamlı bir ilişki (r=-,237) bulunmamıştır. SONUÇ: Bu araştırmada, yaşlılarda depresif belirtilerin az görüldüğü ve sosyal destek algısının yeterli olduğunu bulunmuştur.
Spatio-temporal analysis of cetacean strandings and bycatch in a UK W sheries hotspot

Marine vertebrate strandings data can provide insights into the long-term dynamics of cetacean populations, and the threats they face. We investigate whether the spatio-temporal patterns of cetacean strandings around Cornwall, SW Britain, have changed in the past century. Analysis of strandings from 1911 to 2006 (n = 2,257) show that, since the mid-1970s, the relative frequency of strandings of common dolphins (Delphinus delphis), harbour porpoises (Phocoena phocoena) and pilot whales (Globicephala melas) has increased signiWcantly. Seasonal peaks in strandings frequencies are apparent, between December and March for harbour porpoises and common dolphins, and between November and January for pilot whales. There were signiWcant positive trends in the number of common dolphin and harbour porpoise strandings, as a proportion of total strandings, over time. Strandings of common dolphins, porpoises and all other species occur more frequently on the south coast of Cornwall. A total of 415 cetaceans were subject to full veterinary necropsy to determine cause of death, between 1990 and 2006, and 253 (61%) of these individuals were determined to have died due to bycatch in Wshing gear. Analyses of industrialised Wshing pressure in UK waters show the seas around Cornwall to be one of the Electronic supplementary material The online version of this article (doi:10.1007/s10531-008-9377-5) contains supplementary material, which is available to authorized users. R. H. Leeney · R. Amies · A. C. Broderick · M. J. Witt · B. J. Godley (&) Centre for Ecology and Conservation, University of Exeter, Cornwall Campus, Tremough, Penryn, Cornwall TR10 9EZ, UK e-mail: B.J.Godley@exeter.ac. uk Present Address: R. H. Leeney Provincetown Center for Coastal Studies, 5 Holway Avenue, Provincetown, MA 02657, USA Present Address: R. Amies School of Marine and Tropical Biology, James Cook University, Townsville, QLD 4811, Australia J. Loveridge · J. Doyle Cornwall Wildlife Trust Marine Strandings Network, Cornwall, UK
Bellhop – A modeling approach to Sound propagation in the ocean

Bellhop[1] is a beam tracing approach for predicting acoustic pressure fields in ocean environments. It is written by Michael Porter as part of the Acoustic Toolbox (available at the website of the Ocean Acoustic Library). It can product a variety of outputs which include transmission loss, eigenrays, arrivals and received time-series. It is also designed for range-dependence on the top and bottom boundaries, and the sound speed profile as well. The default input file of Bellhop could not deal with the situation in which the sea bottom is elastic medium. This report describes how to generate the effective reflection coefficient of the elastic bottom by using the Bounce model in the Acoustic Toolbox.
Prospective Multicenter Study Predictive Factors of Contralateral Paratracheal Lymph Node Metastasis in Papillary Thyroid Cancer :

Objective. To analyze patterns of central lymph node (LN) metastasis to specific compartments in the neck and predictive factors of contralateral paratracheal LN metastasis in patients who underwent prophylactic bilateral central LN dissection for papillary thyroid cancer (PTC). Study Design. Prospective study. Setting. Multitertiary centers. Subjects and Methods. One hundred forty consecutive patients underwent total thyroidectomy and prophylactic bilateral central LN dissection for unilateral PTC without evidence of central LN metastatic disease based on preoperative ultrasound imaging. The central LN compartment was divided into prelaryngeal, ipsilateral/contralateral paratracheal, and pretracheal regions. The patterns of central LN metastasis and clinicopathologic variables for predicting contralateral metastasis were analyzed. Results. Fifty-one (36.4%) of 140 patients had nodal involvement in the central compartment. Twelve (23.5%) patients had ipsilateral paratracheal LN metastasis, 17 (33.3%) had ipsilateral paratracheal and pretracheal LN metastasis, 14 (27.5%) had bilateral paratracheal LN metastasis, 9 (17.6%) had pretrachealonly LN metastasis, and 8 (15.7%) had prelaryngeal LN metastasis. Ipsilateral paratracheal LN metastasis was found to independently predict contralateral paratracheal LN metastasis in patients without central LN metastatic disease. Conclusions. Contralateral paratracheal LN metastasis is associated with ipsilateral paratracheal LN metastasis. This information may help to determine the optimal extent of prophylactic central LN dissection in patients with PTC.
Effect of Russian Current and Angle Specific Isometric Exercise on Quadriceps Femoris Muscle Torque

This study was conducted to investigate and compare the effect of Russian current and angle specific isometric exercise on quadriceps femoris muscle maximum voluntary isometric torque (MVIT). Total of sixty healthy males with mean age (241.4 years), mean height (1625.4cm), and mean weight (72.54.1 Kg) participated in the study. The subjects were randomly divided into four equal groups. Group I (exercise group) trained with angle specific resisted isometric exercise at angle 90 degree knee flexion, group II (Russian current group) trained with Russian current, group III trained with both exercise and Russian current applied at alternate separate sessions, group IV trained with exercise superimposed with Russian current. The schedule of training was six days/week for six weeks. Measurements of maximum voluntary isometric torque were conducted pre and post administration of the programs. Analysis of the data revealed that there was significant increase in MVIT of post measurements compared to the pre measurement in all groups (P<0.0001). The percentage of change in MVIT (MVIT%) of the four studied group were 28.5%, 27.5%, 37.5%, and 41.7% respectively. Comparisons between groups showed that there was non-significant increase of torque in group I (exercise group) than in group II (Russian group) (P>0.05). Combined exercise and Russian current in groups III and IV resulted in a significantly higher torque than those recorded in groups I and II after exercise or Russian alone (P<0.001). Also training with exercise superimposed with Russian current in group IV caused significantly higher MVIT than those in group III trained with combined exercise and Russian current at alternate separate sessions day (P<0.05). In conclusion Russian current and angle specific isometric exercise are equally effective in increasing muscle strength. Combined Russian current and angle specific isometric exercise are more efficient in increasing muscle strength than using each alone. Exercise superimposed with Russian current achieves the highest strength gain.
Young age Iraqi Women with Breast Cancer : an overview of the correlation among their clinical and pathological profile

Globally, breast cancer is the most frequently diagnosed cancer in women. Young women with breast cancer represent a subset of breast cancer with its unique characteristics and outcome compared to older women. To assess Iraqi female breast cancer patients’ clinical profile, and evaluate patients’ molecular profile. An observational cross-sectional study conducted in the tertiary hospital, Baghdad Medical City, Baghdad oncology teaching hospital. 1349 women with breast cancer of whom 202 had age less or equal to 40 years involved. The prevalence of young with breast cancer (defined as ≤40 years) as 15%, (7.9%, 4.8%, 2.1% and 0.2% for 36 – 40, 31 – 35, 26 – 30 and 20 – 25 years respectively). There was high ER and PR positive status 74.4% and 74%, with 23.1% Her2 positive (+3) while 16.3% were equivocal (+2), and 10.2% as triple negative. Luminal A is the most molecular subtype 50%. There was a slight positive trend of increase ER and PR expression with an increase in age and there was a slight negative trend of increment of Her2 expression and triple negative with increase in age. Lower age associated with increased odds for having stage IV or metastatic disease. The highest age group was 36 – 40 years in the young women, with the highest expression for ER status and the lowest for triple-negative disease, around one-quarter of the patients express her 2 positive diseases, age appear to have the weak effect on hormonal and immune-histochemistry characters of the tumors.