Miracle-dz/UniFAR-FTUs huggingface dataset:
Acinetobacter spc. : A major isolates of nosocomial infection's clinical significance and antimicrobial susceptibility.

Acinetobacter spp. is ubiquitous, aerobic gram-negative coccobacilli that are now emerging as an important nosocomial pathogen. In our study over a period of one year (January 2002- December 2002) at BPKIHS, a tertiary care hospital, froma total no. of 1089 isolates frompus/ aspirates of ICU, Burns, Orthopedic and other post operative wards, 146 isolates (13.4%) were Acinetobacter spp. Out of 146, 23 isolates of Acinetobacter spp. were sensitive to base line drugs. Remaining 123 strains of Acinetobacter spp. were resistant to Cefotaxime (99.2%), Ceftazidime (98.4%), Tobramicin (95.9%), Amikacin (96.7%), Netilmicin (89.43%), Ciprofloxacin (96.7%). Apart fromthese antibiotics none of the strains were sensitive to Piperacillin. Journal of Institute of Medicine Vol.27(2) 2005
Update on myocardial perfusion imaging: role of regadenoson

Correspondence: Robert C Hendel Midwest Heart Specialists, Central DuPage Hospital, Suite 301, 25 N Winfi eld Road, Winfi eld, IL 60190, USA Tel +1 630 510 9244 Fax +1 630 510 9557 Email rhendel@midwestheart.com Abstract: Pharmacologic stress myocardial perfusion imaging (MPI) is a noninvasive method for the evaluation of coronary artery disease in patients unable to exercise adequately. Commonly used pharmacologic stress agents (adenosine, dipyridamole, and dobutamine) have a high incidence of bothersome and potentially serious side-effects, several contraindications to testing, and require continuous infusion with weight-adjusted doses. Newer agents are, therefore, needed. Selective activation of A 2A adenosine receptors on the coronary vasculature should provide coronary vasodilation for MPI with fewer or less severe side-effects associated with nonspecifi c agonists, such as adenosine and dipyridamole. Regadenoson is the fi rst selective A2A receptor agonist to be approved as a pharmacologic stress agent for use with radionuclide MPI. Regadenoson is administered at a standard, fi xed dose of 400 μg from a prefi lled syringe or single-use vial by intravenous injection over 10 seconds. In clinical trials, regadenoson provided good quality images yielding accurate diagnostic information, and was safe and well tolerated. No infusion pump is required and the stress protocol is brief. Further studies are now required to evaluate regadenoson as a stress agent in combination with low-level exercise, with prior caffeine intake, and in patients with asthma or chronic obstructive pulmonary disease.
L’internazionalizzazione delle imprese italiane nell’Est Europeo: evidenze e prospettive

L’obiettivo della nostra analisi e quello di tenere sotto controllo icomportamenti delle imprese italiane, poste di fronte ad un quadro ambientalecaratterizzato da incessante progresso teconologico, minacce competitive portatedalle economie emergenti, regole di “governance” del macrosistema economico chehanno profondamente ridotto i gradi di liberta un tempo a disposizione delle impresenella definizione delle strategie competitive. Innovazione ed internazionalizzazionedivengono, in questo quadro, imperativi strategici e prassi “ordinarie” nella gestionedelle imprese.Questo rapporto tratta il tema delle strategie di internazionalizzazione delleimprese italiane verso i paesi dell’Europa centro-orientale. L’interesse verso questipaesi si motiva in forza di numerose e palesi ragioni; si tratta di paesi “vicini”,caratterizzati da una significativa dinamica di sviluppo, e in via di progressivaintegrazione, con i paesi della “core Europe”, all’interno di un’Unione Europea cheva progressivamente allargando il proprio perimetro.
Maximum a Posteriori Estimation in Dynamical Models of Primary HIV Infection

Dynamical models based on ordinary differential equations (ODE) are increasingly used to model viral infections such as HIV. This kind of model is based on biological knowledge and takes into account complex non-linear interactions between markers. The estimation of such models is made difficult by the lack of analytical solutions and several methods based on Bayesian or frequentist approaches have been proposed. However, because of identifiability issues, in a frequentist approach some parameters have to be fixed to values taken from the literature. In this paper we propose a Maximum A Posteriori (MAP) approach to estimate all the parameters of ODE models, allowing prior knowledge on biological parameters to be taken into account. The MAP approach has two main advantages: the computation time can be fast (relative to the full Bayesian approach) and it is straightforward to incorporate complex prior information. We applied this method to an original model of primary HIV infection taking into account several biological hypotheses for the HIV-immune system interaction. Parameters were estimated using HIV RNA load and CD4 count measurements of 710 patients from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) Collaboration.
The effects of Software Design Complexity on Defects in Open Source Systems

The aim of this thesis is to investigate whether there is a general correlation between post-delivery defects and system design complexity by studying measures relating to Data, Structural and Procedural complexity in object-oriented systems and determining their effect on post dehvery defects. A fur ther aim is to determine whether, during the detailed design phase, measured Data Complexity can estimate measured Procedural Complexity and Class Size for the implemented system. This research is based on prior work of Card and Glass, who introduced a System Complexity Model as a combination of Structural and Data Complexity. They applied their model to eight similar FORTRAN (RATFOR) systems. This research both investigates and extends the Card and Glass model for applying to the object-oriented environment. Several adjustments are made to accommodate important characteristics of object-oriented design and language, such as "inheritance" and "encapsulation". Based on these adjustments, a new System Complexity Model is proposed, which is then applied to 104 open-source systems to investigate its effectiveness in estimating post-delivery defects. The necessary data are extracted from the source code of systems maintained within SourceForge a popular open-source repository. Included in the data are. Version Downloads and the Number of Developers considered as independent variables for predicting user reported defects. The Spearman's rank correlation coefficient and Generalized Linear Model (GLM) with Poisson distribution are used to analyze the collected data. The results show that the newly proposed System Complexity (Structural + Data) is not significant for estimating the volume of post-delivery defects (Post-DD). When Structural and Data Complexity are analyzed separately, the results show that Structural Complexity is highly significant in estimating the number of post-DDs. Other important findings include: 1) Data Complexity can effectively estimate Procedural Complexity and Class Size, 2) The ratio of System Complexity and Procedural Complexity is useful for estimating the probability of Defect Density and Class Size. This ratio represents the mapping of metrics obtained during the detailed design phase with Procedural Complexity which is measurable during implementation (writing of the source code).
Asociación entre la concentración plasmática de proteína C reactiva y el volumen de hiperplasia neointimal en pacientes tratados con implante de stent liberador de zotarolimus. Análisis volumétrico con ecografía intracoronaria tridimensional

Introduction and objectives. C-reactive protein (CRP) is an inflammatory marker that predicts cardiac events in patients with coronary syndromes. However, data on the relationship between the CRP level and in-stent restenosis are contradictory. The objective of this study was to investigate the relationship between the basal CRP level and the neointimal hyperplasia volume measured by intracoronary ultrasound 4 months after implantation of a zotarolimus-eluting stent. Methods. The study included 40 consecutive patients who underwent zotarolimus-eluting stent implantation. Patients were divided into quartiles according to their preprocedural CRP level. Intracoronary ultrasound was performed after stent implantation and at 4 months, and the neointimal hyperplasia volume was determined using Simpson’s rule. Correlation and linear regression analyses were used to evaluate the relationships between variables. Multivariate analysis was used to identify variables that were independently related to neointimal hyperplasia volume. Results. The patients’ mean age was 58 (8) years, 55% were male, and 40% had diabetes mellitus. There was no difference in baseline characteristics between the quartiles. The hyperplasia volumes were 4.8 (4.2) µL and 15.8 (10.0) µL in the first and fourth quartiles, respectively (P<.001). There was a significant positive correlation between the CRP level and neointimal hyperplasia volume (r=0.64, P=.0001). The CRP level, the postimplantation lumen volume, and the final deployment pressure were all independent predictors of neointimal hyperplasia. Conclusions. In this study, an independent correlation was observed between the CRP level before zotarolimuseluting stent implantation and the neointimal hyperplasia volume at 4-month follow-up.
Inexperienced trainees doing more Section 136 emergency assessments

Opportunities for emergency assessments by junior trainees are certainly being reduced, largely as a result of rota merges to comply with the European Working Time Directive for doctors[1][1] and New Deal. [2][2] However, rather paradoxically, in areas where Section 136 suites have been created as an
Times Square Red Times Square Blue

Thank you for downloading times square red times square blue. Maybe you have knowledge that, people have look numerous times for their chosen books like this times square red times square blue, but end up in malicious downloads. Rather than reading a good book with a cup of coffee in the afternoon, instead they are facing with some malicious virus inside their laptop. times square red times square blue is available in our digital library an online access to it is set as public so you can get it instantly. Our books collection hosts in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the times square red times square blue is universally compatible with any devices to read.
Clinical Study Retrospective Analysis of Efficacy and Safety of Tocilizumab Treatment in Patients with Severe Systemic-Onset Juvenile Idiopathic Arthritis Followed for 12 Months

The results of the retrospective study evaluating efficacy and safety of tocilizumab treatment in 75 patients with severe systemiconset juvenile idiopathic arthritis refractory to standard immunosuppressive therapy are presented in the paper. Inactive disease was documented in 64% of patients after 6 months of treatment and in 73% of patients after 12 months. Adverse events manifested as mild andmoderate infections as well as laboratory abnormalities: leukopenia, neutropenia, and elevated aminotransferase levels.
Análisis de la intensidad de juego durante los partidos de play-off en jugadores de baloncesto en silla de ruedas (Game intensity analysis of wheelchair basketball players during play-off matches)

El principal objetivo del estudio fue analizar la intensidad de juego en jugadores de baloncesto en silla de ruedas (BSR) durante los partidos de play-off. En este estudio participaron nueve jugadores masculinos de BSR de primera division (34,8 ± 7,8 anos). En total se analizaron seis partidos y los participantes fueron divididos en tres grupos segun los minutos jugados: jugadores que jugaron 30-40 minutos (BSR 30-40 ), jugadores que jugaron 20-29 minutos (BSR 20-30 ) y los que jugaron entre 1 segundo y 19 minutos (BSR 1-19 ). Durante todos los partidos se monitorizo la frecuencia cardiaca (FC), y ademas, se obtuvo la temperatura timpanica y la concentracion de lactato sanguineo antes e inmediatamente despues de cada partido. Se encontraron diferencias significativas (P 85% de la FCmax), con un aumento significativo de la temperatura y la concentracion de lactato sanguineo. Los entrenadores y preparadores fisicos deberian tener en cuenta estas diferencias fisiologicas en funcion de los minutos jugados a la hora de planificar la temporada y los descansos post partido. Abstract. The main objective of the study was to analyze the game intensity in wheelchair basketball players (WB) during play-off matches. This study involved nine WB players of Spanish first division league (34.8 ± 7.8 years). Six play-off matches were analyzed and participants were divided into three groups according to the minutes they had played: players who had played between 30-40 minutes (WB 30-40 ), players who had played between 20-30 minutes (WB 20-30 ) and players who had played between 1 second and 20 minutes (WB 1-19 ). For every game the heart rate (HR) was monitored by telemetry, and in addition, the tympanic temperature and blood lactate concentration samples were obtained before and immediately after each match. Significant differences (P 85% of maximum HR) than other groups, with a significant increase in body temperature and blood lactate concentration. Coaches and physical trainers should be aware of these physiological differences when planning the season and post-match sessions.
Das Essener-Lern-Modell (ELM): Ein Vorgehensmodell zur Entwicklung computerunterstützter Lernumgebungen

Das Essener-Lern-Modell (ELM) ist ein generisches Vorgehensmodell, das den Entwicklungsprozess von computerunterstutzten Lernumgebungen unterstutzt. Wahrend Modelle der Softwareentwicklung, didaktische Modelle oder Domanen-spezifische Modelle nur Teilbereiche des Entwicklungsprozesses umfassen, unterstutzt das Essener-Lern-Modell den Entwicklungsprozess von der Curriculumentwicklung bis zu Entwicklung von Lerneinheiten. Hinzu kommen Querschnittsfunktionen wie Projektmanagement, Prozessintegration und Qualitatssicherung. Das Essener-Lern-Modell integriert die Spezifikation und Verwendung von Lerntechnologiestandards wie LOM und SCORM. Zusatzlich wird eine Spezifikation zur Beschreibung des Anwendungskontextes und von didaktischen Modellen entwickelt, die in Verbindung mit bestehenden Standards ein Rahmenkonzept fur die Interoperabilitat von Lernmanagementsystemen und Lernumgebungen liefert. Die ELM-Applikation ist ein Werkzeug, das zur Unterstutzung von Entwicklungsteams implementiert wurde und die Konzepte des Essener-Lern-Modells umsetzt. Aus den Konzepten und Spezifikationen werden von der ELM-Applikation computerunterstutzte Lernumgebungen in XML generiert, die exemplarisch dargestellt werden. The Essen Learning Model is a generic development model, supporting developers, educators, and users on different levels of educational activities. Existing software engineering models, pedagogical models, and domain-specific models solely support parts of the development process. The Essen Learning Model provides concepts for project management, quality assurance, process integration, curriculum development, and the development of learning sequences and learning units. Emerging learning technology standards such as SCORM and LOM are integrated in the development process, minimizing the authors? specification effort. Additionally, a detailed specification for context and didactical models was developed. Combining these standards with existing learning technology standards leads to an interoperable framework for learning management systems and learning environments. Furthermore, the ELM application is a tool to support development processes. Using this tool, XML-based learning environments and specifications of learning technology standards are generated. Finally, learning environments, designed with ELM, are presented.
SUPPLY CHAIN SCHEDULING FOR MULTI-MACHINES AND MULTI-CUSTOMERS

Manufacturing today is no longer a single point of production activity but a chain of activities from the acquisition of raw materials to the delivery of products to customers. This chain is called supply chain. In this chain of activities, a generic pattern is: processing of goods (by manufacturers) and delivery of goods (to customers). This thesis concerns the scheduling operation for this generic supply chain. Two performance measures considered for evaluation of a particular schedule are: time and cost. Time refers to a span of the time that the manufacturer receives the request of goods from the customer to the time that the delivery tool (e.g. vehicle) is back to the manufacturer. Cost refers to the delivery cost only (as the production cost is considered as fixed). A good schedule is thus with short time and low cost; yet the two may be in conflict. This thesis studies the algorithm for the supply chain scheduling problem to achieve a balanced short time and low cost. Three situations of the supply chain scheduling problem are considered in this thesis: (1) a single machine and multiple customers, (2) multiple machines and a single customer and (3) multiple machines and multiple customers. For each situation, different vehicles characteristics and delivery patterns are considered. Properties of each problem are explored and algorithms are developed, analyzed and tested (via simulation).
Therapy for hyperthermia-induced seizures in Scn1a mutant rats

熱性けいれん(febrile seizures : FS)とは,乳幼児 期に発熱に伴って生じる全身けいれんで,中枢神経系 感染症や病理学的異常,外傷などに起因しないものを いう. 熱性けいれんの予後は,原則として良好で, ほとんどの患者はけいれん発作を1回しか経験しない 単純性熱性けいれんである. しかし,2~7%の患者 は,6歳を超えてなお生じる熱性けいれんとその後の 無熱性けいれんを特徴とする全般てんかん熱性けいれ んプラス(generalized epilepsy with febrile seizures plus : GEFS+)を発症する. また,頻度的には稀 であるが,乳児重症ミオクロニーてんかん(severe myoclonic epilepsy of infancy : SMEI)も乳幼児期から 熱性けいれんを繰り返し,時に生命の危険を伴うてん かん重積状態に陥りやすいことから,熱性けいれんの 適切な治療は大変重要である.
Comparison between creatine kinase brain isoenzyme (CKBB) activity and Sarnat score for prediction of adverse outcome following perinatal asphyxia

Abstract Aim: To assess whether plasma creatine kinase brain isoenzyme (CKBB) levels or Sarnat scores are more accurate for prediction of poor neurological outcome in babies with suspected birth asphyxia. Methods: In a retrospective study of 97 babies CKBB levels were compared to the presence of severe hypoxic ischaemic encephalopathy (HIE) as a predictive test for these outcomes: developmental delay, cerebral palsy, visual problems, deafness or death from perinatal asphyxia. The tests were compared using positive predictive values (PPV) and likelihood ratios (LR) with confidence intervals (CI) Results: 3 babies had died from perinatal asphyxia and 14 survivors were found to have neurological or developmental problems. CKBB was elevated in babies with severe HIE (p=0.0004). A receiver operator characteristic (ROC) curve showed the optimal discriminating value for CKBBto be 21 IU/L but theCKBB was a poor predictive test. For prediction of adverse outcome: CKBB > 21 sensitivity 76％, specificity 40％, PPV 21％ and LR 1.3 (95％ CI 0.8–1.7). Severe HIE sensitivity 53％, specificity 95％, PPV 69％ and LR 10.6 (95％ CI 3.8–29.2). Conclusion: CKBB is elevated following birth asphyxia but is a poor predictor of adverse neurological outcome.
Lessons learned during real-life QoE assessment

Subjective video quality experiments are usually conducted inside controlled lab environments, where stringent demands are imposed in terms of lighting conditions, screen calibration and position of the test subjects. However, these controlled lab environments might differ from a more natural setting such as watching television at home. This, in turn, will influence subjects’ Quality of Experience. In previous research, we conducted a series of subjective experiments, mimicking the natural environment of the targeted use cases as much as possible. In this paper, we provide an overview of these conducted studies and summarize our main research findings. Our results show that the environment and overall experimental setup influence the primary focus of the test subjects. Consequently, a significant difference in impairment visibility, tolerance and annoyance is observed compared to conducting experiments in pristine lab environments. Our results highlight the importance of considering the targeted use case and assessing video quality in more natural environments.
Current and future role of methotrexate in the therapeutic armamentarium for rheumatoid arthritis

Methotrexate (MTX) has been used for rheumatoid arthritis (RA) treatment since 1980. It is the most common effective disease-modifying antirheumatic drug (DMARD) for RA, and is considered to be the anchor drug, to which other DMARDs or biological agents are added to, in order to achieve an optimal therapeutic effect. MTX improves signs and symptoms to a similar degree as anti-TNF agents. However, it seems to inhibit radiographic progression less effectively than anti-TNF agents. The appropriate route of administration and optimal dose should be individualized depending on the profile and response of the patient. It seems to be one of the safest DMARDs, while there is evidence that patients treated with MTX have lower mortality, especially due to cardiovascular causes. Currently, there is no reliable way to predict which patients will respond to treatment with MTX, and who will experience side effects, the answer to which remains to be clarified.
EFFECTS OF AN EIGHT-WEEK PROGRESSIVE RESISTANCE TRAINING PROGRAM ON BALANCE IN PERSONS WITH MULTIPLE SCLEROSIS

of Thesis Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Master of Science EFFECTS OF AN EIGHT-WEEK PROGRESSIVE RESISTANCE TRAINING PROGRAM ON BALANCE IN PERSONS WITH MULTIPLE SCLEROSIS By Gregory M. Gutierrez May 2005 Chair: Mark Tillman Major Department: Department of Exercise and Sports Sciences Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system, which leads to degeneration of the myelin sheaths that protect the neural axons. MS can affect any part of the central nervous system, so persons with MS experience a wider variety of symptoms than most neurological disorders, including problems with balance and strength loss. The aim of this study was to determine if a strength training program, designed to increase muscle strength, could improve postural sway measures in persons with MS. Nine MS subjects and four non-MS controls participated in an eight-week strength-training program. They were tested for isometric strength for their knee extensors, knee flexors, plantar flexors, and dorsiflexors prior to and following the strength-training program. Postural sway was also evaluated before and after training in 5 different stance conditions: 1) self-selected, 2) feet 6 inches apart, 3) feet 6 inches apart on a foam pad, 4) semitandem, and 5) tandem. Four dependent variables were calculated from the tests of postural sway: path length (PL), average speed (AS), antero-posterior
About the fuzzy grade of the direct product of two hypergroupoids

The aim of this paper is the study of the sequence of join spacesand fuzzy subsets associated with a hypergroupoid. In thispaper we give some properties of the membership function$widetildemu_{otimes}$ corresponding to the direct pro-duct oftwo hypergroupoids and we determine the fuzzy grade of thehypergroupoid $langle Htimes H, otimesrangle$ in a particularcase.
Time domain algorithm for the estimation of two sinusoidal frequencies

A computationally simple algorithm is presented that measures one or two frequencies using lookup tables and simple adders. The algorithm is based on a real-time processing of instantaneous frequency and envelope. The algorithm provides a maximum likelihood estimate in the single frequency case. Oversampling is required and the algorithm cannot estimate three or more frequencies. A complete error analysis is presented along with simulation results. >