Miracle-dz/UniFAR-FTUs huggingface dataset:
Gene Polymorphisms Impact the Risk of Rejection With Hemodynamic Compromise: A Multicenter Study

Background. Rejection with hemodynamic compromise (RHC) is associated with high mortality in heart recipients. This study investigates the association between genetic polymorphisms and RHC in pediatric heart recipients. Methods. Data from 532 pediatric heart recipients from six centers in the Pediatric Heart Transplant Study were analyzed for time to RHC by recipient race, age at transplantation, and genotype at 13 genetic polymorphisms (TNF-&agr; A-308G, IL-6 G-174C, INF-&ggr; T+874A, IL-10 G-1082A, C-819T, and C-592A; FAS A-670G, FASL C-843T, and ACE I/D; and VEGF A-2578C, C-1451T, C+405G, and -2549 I/D). Results. RHC occurred in 126 (23.7%) patients during the study period. Adjusting for age and race, IL-10 G-1082A, FAS A-670G, and ACE I/D genotypes were associated with RHC. IL-10 G-1082A GG genotype was associated with decreased risk of RHC with an adjusted hazard ratio (HR) of 0.49 (95% confidence interval [CI], 0.27–0.90; P=0.020). FAS A-670G AA genotype was associated with increased risk of RHC with an adjusted HR of 1.84 (95% CI, 1.25–2.69; P=0.002). ACE II genotype was associated with decreased risk of RHC with an adjusted HR of 0.58 (95% CI, 0.36–0.95; P=0.031). Conclusions. Recipients with a high anti-inflammatory and immune-regulatory genetic profile (high interleukin-10) were protected from RHC. Conversely, recipients with a pro-apoptotic genetic profile (high Fas) or high angiotensin-1-converting enzyme producing genotype were at increased risk of RHC. This represents progress toward understanding the genetic risk factors of posttransplantation outcomes in pediatric heart recipients.
Opportunity recognition by international high-technology start-up and growth photonics firms

For high-technology firms that depend on foreign markets from the outset, identifying opportunities is a matter not only of business development but of survival. This study contributes to the opportunity recognition literature by exploring the paths taken by these international entrepreneurs to find opportunities in foreign markets. Moreover, it examines the paths of firms at different lifecycle stages. Based on in-depth interviews with five start-ups and five growth firms in Canada specialised in photonics, this research delves into both the personal characteristics of the entrepreneurial teams and the methods they use to find international opportunities. The sources they use as well as the actions undertaken are examined and compared. The practical goal is to identify path components which may be adjusted in start-up firms to improve the probability of finding and developing fruitful opportunities.
An Investigation into How B2-C2 Level English as a Foreign Language (EFL) Learners Display Their Pragmatic Competence in Speaking

The importance of testing second language (L2) learners’ pragmatic competence is becoming evident following increasing research (e.g. Ross and Kasper, 2013). Current pragmatic tests mainly use the Speech Act Theory as a theoretical framework and discourse completion tasks (DCTs) as test instruments. However, these have been criticized lately for overlooking the importance of the discursive side of pragmatics. The main objective of this research was to contribute towards the assessment of B2-C2 level EFL learners’ pragmatic competence by experimenting with task formats that allow the examination of extended oral discourse. The empirical study examined how two speaking task formats allowed test takers to display their pragmatic competence. It also aimed to identify some criterial features defining the level of EFL learners’ pragmatic competence. Six university students took part in this mixed-method study, which included four monologic and two dialogic tasks, followed by a semi-structured interview. Performance of the tasks was video recorded, transcribed and analyzed quantitatively as well as qualitatively using a Conversation Analytic framework. It was concluded that both task formats allow learners to display their pragmatic competence in terms of the sequential organization of speech and selection/use of pragmalinguistic devices. Results also showed that with increasing proficiency the number and range of pragmalinguistic devices seemed to increase and the sequential organization of speech tended to become somewhat more natural.
Interventional Oncology in Hepatocellular Carcinoma: Progress Through Innovation

AbstractThe clinical management of hepatocellular carcinoma has evolved greatly in the last decade mostly through recent technical innovations. In particular, the application of cutting-edge image guidance has led to minimally invasive solutions for complex clinical problems and rapid advances in the field of interventional oncology. Many image-guided therapies, such as transarterial chemoembolization and radiofrequency ablation, have meanwhile been fully integrated into interdisciplinary clinical practice, whereas others are currently being investigated. This review summarizes and evaluates the most relevant completed and ongoing clinical trials, provides a synopsis of recent innovations in the field of intraprocedural imaging and tumor response assessment, and offers an outlook on new technologies, such as radiopaque embolic materials. In addition, combination therapies consisting of locoregional therapies and systemic molecular targeted agents (e.g., sorafenib) remain of major interest to the field and are also discussed. Finally, we address the many substantial advances in immune response pathways that have been related to the systemic effects of locoregional therapies. Knowledge of these new developments is crucial as they continue to shape the future of cancer treatment, further establishing interventional oncology along with surgical, medical, and radiation oncology as the fourth pillar of cancer care.
Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma

While the phosphatidylinositol 3‐kinase (PI3K)/AKT signaling pathway is known to be activated in multiple sporadic cancers, the role of this pathway in familial tumors is mostly unknown. We searched for alterations in the catalytic domain of PI3K (PIK3CA), PTEN and KRAS, all of which may contribute to PI3K/AKT pathway activation, in a total of 160‐familial colorectal (CRC) and endometrial carcinomas (EC), stratified by the presence vs. absence of germline mutations in DNA mismatch repair (MMR) genes. PIK3CA alterations (consisting of point mutations or low‐level amplification, which were mutually exclusive with 1 exception) occurred in 10/70 (14%) of CRCs and 19/90 (21%) of ECs. Within ECs, amplification was significantly associated with the subgroup lacking germline mutations in MMR genes (familial site‐specific endometrial cancer) (p = 0.015). Decreased or lost PTEN expression was characteristic of endometrial tumourigenesis (51/81, 63%, in EC compared with 24/62, 39%, in CRC, p = 0.004) and KRAS mutations of colorectal tumourigenesis (19/70, 27% in CRC vs. 9/89, 10%, in EC, p = 0.006) regardless of the MMR gene mutation status. PIK3CA alterations frequently coexisted with PTEN or KRAS changes. Combined with published studies on sporadic tumors, our data broaden the understanding of the role for PI3K pathway genes in human tumorigenesis. © 2007 Wiley‐Liss, Inc.
Human NK cells can lyse porcine endothelial cells independent of their expression of Galα(1,3)‐Gal and killing is enhanced by activation of either effector or target cells

Abstract: Background: Xenotransplantation of pig organs may provide an approach to alleviate the severe shortage of human organs. Natural antibodies against Galα(1,3)‐Gal (αGal) epitopes cause hyperacute rejection of pig organs in primates. However, evidence for the role of αGal in the natural killer (NK) cell‐mediated xenoresponse has been contradictory.
New Electropositive Filter for Concentrating Enteroviruses and Noroviruses from Large Volumes of Water

ABSTRACT The U.S. Environmental Protection Agency's information collection rule requires the use of 1MDS electropositive filters for concentrating enteric viruses from water, but unfortunately, these filters are not cost-effective for routine viral monitoring. In this study, an inexpensive electropositive cartridge filter, the NanoCeram filter, was evaluated for its ability to concentrate enteroviruses and noroviruses from large volumes of water. Seeded viruses were concentrated using the adsorption-elution procedure. The mean percent retention of seeded polioviruses by NanoCeram filters was 84%. To optimize the elution procedure, six protocols, each comprising two successive elutions with various lengths of filter immersion, were evaluated. The highest virus recovery (77%) was obtained by immersing the filters in beef extract for 1 minute during the first elution and for 15 min during the second elution. The recovery efficiencies of poliovirus, coxsackievirus B5, and echovirus 7 from 100-liter samples of seeded tap water were 54%, 27%, and 32%, respectively. There was no significant difference in virus recovery from tap water with a pH range of 6 to 9.5 and a water flow rate range of 5.5 liters/min to 20 liters/min. Finally, poliovirus and Norwalk virus recoveries by NanoCeram filters were compared to those by 1MDS filters, using tap water and Ohio River water. Poliovirus and Norwalk virus recoveries by NanoCeram filters from tap and river water were similar to or higher than those by the 1MDS filters. These data suggest that NanoCeram filters can be used as an inexpensive alternative to 1MDS filters for routine viral monitoring of water.
The Impact of Size and Growth Decisions on Turkish Banks' Profitability

The aim of this study is to examine whether bank profitability is affected by the decisions regarding bank size and growth rate. All parameter estimates of regression models are based on fixed-effect panel regression analyses. Our data covers all banks publicly traded on the BIST during the period 2009Q1-2016Q1. Our empirical findings show that there exists a nonlinear (concave) association between different size measures and profitability. In spite of the fact that growth rate tend to be positively associated with profitability, the impact of this variable is not statistically significant.
Oral Clonidine Provocative Test in the Diagnosis of Growth Hormone Deficiency in Childhood: Should We Make the Timing Uniform?

Introduction: Oral clonidine is one of the most frequent drugs used for the diagnosis of growth hormone deficiency (GHD), but the duration of the test, depending on which European centres use it, is not uniform and can vary from 120 to 150 min or even 180 min. Subjects and Methods: To standardize this test, evaluating the possibility to shorten it to 90 min, we investigated the response of GH to the oral clonidine test in 291 children evaluated for short stature (height <–2 SD). Of these, 164 were diagnosed as idiopathic short stature (ISS) and 127 as GHD. In these patients, we calculated: (1) the frequency distribution of the GH peaks to clonidine in GHD and in ISS at various times; (2) the percentage of GH peaks to clonidine before and after 90 min in all and in ISS children; (3) the percentage of the first GH value ≧10 ng/ml before 90 min and after 90 min in ISS. Results: GH peak distribution varied between 30 and 180 min, even though the vast majority of peaks occurred between 30 and 60 min. There was no significant difference (p > 0.05) in the peak distribution between ISS and GHD children. The percentages of GH peaks within 90 min were 92.1% in all children and 95.7% in ISS. If considering the first value of GH ≧10 ng/ml this last percentage reaches 96.3%. Conclusion: Our study suggests that the oral clonidine test can be administered for only 90 min without significantly changing its validity. This test should be standardized at 90 min in European protocols just as in those currently used in the USA in order to reduce the discomfort of patients and the cost of this diagnostic procedure.
Colour-Doppler ultrasonography of carotid vessels in patients treated with antiretroviral therapy: a comparative study

Objectives: To evaluate the correlation between antiretroviral therapy (ART) and lesions of the carotid vessels using an ultrasound colour-Doppler technique. Design: A total of 293 HIV-1 infected patients underwent epiaortic vessel ultrasonography: 105 on treatment with protease inhibitors (PI) (group I), 125 PI-naive patients treated with a non-nucleoside reverse transcriptase inhibitor-including regimen (group II), and 63 patients treated with two nucleoside reverse transcriptase inhibitors or naive to ART (group III). Methods: Intima characteristics, pulsation and resistance indexes, and minimal, peak and mean speed were evaluated using a colour power doppler. Atherosclerotic plaques were described. Independent risk factors and values for glycaemia, cholesterolaemia and triglyceridaemia were considered. Statistical analysis included the Wilcoxon tests, the χ2 test, the Cochran Armitage trend test and the Mantel–Haenszel test and, when necessary, logistic regression analysis. Results: Of the 150 group I patients, 55 (52.4%) presented acquired lesions of the vascular wall at ultrasonography, whereas similar lesions were found in 19 out of 125 (15.2%) patients in group II and in nine of 63 (14.3%) in group III. ART, age, smoking and CD4 T-cell count were the main predictive risk factors for vascular lesions. However, the highest significance was with the use of PI. Conclusions: These data confirm the higher prevalence of premature carotid lesions in the PI-treated patients. A periodic ultrasonographic study of the vascular wall should be included in the follow-up of HIV infected patients.
Can there be benefits from competing legal regimes? The impact of legal pluralism in post-conflict Sierra Leone

We investigate the impact of competition between legal regimes on the number of authoritative acts and amount of fines occurring in rural Sierra Leone. We model state and traditional legal systems as competing authorities with a potential for overlap in their jurisdictions. We are interested in the sign and magnitude of the legal pluralism externality in this region of overlapping authority. We then test the model and estimate the size of the externality coefficient in the context of post-conflict Sierra Leone. Our results show a negative externality between regimes for civil disputes—that is, an increase in the cost of apprehending a person. We also show that there is a reduction in the amount of fines per dispute collected in this shared space. Overall, this indicates that a potential benefit to the local people from multiple competing regimes is a reduction in expected authoritative expropriation.
Integration through the disintegration of law? The ECB and EU constitutionalism in the crisis

ABSTRACT Rather than halting European integration, the euro crisis, in some ways, has accelerated it. However, it is integration of a different type, which departs significantly from the rule of law-based model of integration that traditionally burnished the European Union’s legitimacy. The crisis-induced transformation of the European Central Bank (ECB) captures this trend. Through schemes such as Outright Monetary Transactions, the Bank bolstered its capacity to stabilize the euro without having its mandate formally enlarged, thus confirming the ascendency of technocratic, and often ad hoc, governance over democratically and legally circumscribed alternatives. This article posits the ECB’s expanded and politicized role as the manifestation of a new mode of integration – integration through the disintegration of law – which inverts the court-driven integration-through-law that consolidated the single market. However, the lack of a solid legitimacy base casts doubt on the long-term sustainability of this integration mode.
Active Learning Based Constrained Clustering For Speaker Diarization

Most speaker diarization research has focused on unsupervised scenarios, where no human supervision is available. However, in many real-world applications, a certain amount of human input could be expected, especially when minimal human supervision brings significant performance improvement. In this study, we propose an active learning based bottom-up speaker clustering algorithm to effectively improve speaker diarization performance with limited human input. Specifically, the proposed active learning based speaker clustering has two different stages: explore and constrained clustering. The explore stage is to quickly discover at least one sample for each speaker for boosting speaker clustering process with reliable initial speaker clusters. After discovering all, or a majority, of the involved speakers during explore stage, the constrained clustering is performed. Constrained clustering is similar to traditional bottom-up clustering process with an important difference that the clusters created during explore stage are restricted from merging with each other. Constrained clustering continues until only the clusters generated from the explore stage are left. Since the objective of active learning based speaker clustering algorithm is to provide good initial speaker models, performance saturates as soon as sufficient examples are ensured for each cluster. To further improve diarization performance with increasing human input, we propose a second method which actively select speech segments that account for the largest expected speaker error from existing cluster assignments for human evaluation and reassignment. The algorithms are evaluated on our recently created Apollo Mission Control Center dataset as well as augmented multiparty interaction meeting corpus. The results indicate that the proposed active learning algorithms are able to reduce diarization error rate significantly with a relatively small amount of human supervision.
Genotypic and Epidemiologic Trends of Norovirus Outbreaks in the United States, 2009 to 2013

ABSTRACT Noroviruses are the leading cause of epidemic acute gastroenteritis in the United States. From September 2009 through August 2013, 3,960 norovirus outbreaks were reported to CaliciNet. Of the 2,895 outbreaks with a known transmission route, person-to-person and food-borne transmissions were reported for 2,425 (83.7%) and 465 (16.1%) of the outbreaks, respectively. A total of 2,475 outbreaks (62.5%) occurred in long-term care facilities (LTCF), 389 (9.8%) in restaurants, and 227 (5.7%) in schools. A total of 435 outbreaks (11%) were typed as genogroup I (GI) and 3,525 (89%) as GII noroviruses. GII.4 viruses caused 2,853 (72%) of all outbreaks, of which 94% typed as either GII.4 New Orleans or GII.4 Sydney. In addition, three non-GII.4 viruses, i.e., GII.12, GII.1, and GI.6, caused 528 (13%) of all outbreaks. Several non-GII.4 genotypes (GI.3, GI.6, GI.7, GII.3, GII.6, and GII.12) were significantly more associated with food-borne transmission (odds ratio, 1.9 to 7.1; P < 0.05). Patients in LTCF and people ≥65 years of age were at higher risk for GII.4 infections than those in other settings and with other genotypes (P < 0.05). Phylogeographic analysis identified three major dispersions from two geographic locations that were responsible for the GI.6 outbreaks from 2011 to 2013. In conclusion, our data demonstrate the cyclic emergence of new (non-GII.4) norovirus strains, and several genotypes are more often associated with food-borne outbreaks. These surveillance data can be used to improve viral food-borne surveillance and to help guide studies to develop and evaluate targeted prevention methods such as norovirus vaccines, antivirals, and environmental decontamination methods.
Online Soft-Error Vulnerability Estimation for Memory Arrays and Logic Cores

Radiation-induced soft errors are a major reliability concern in circuits fabricated at advanced technology nodes. Online soft-error vulnerability estimation offers the flexibility of exploiting dynamic fault-tolerant mechanisms for cost-effective reliability enhancement. We propose a generic run-time method with low area and power overhead to predict the soft-error vulnerability of on-chip memory arrays as well as logic cores. The vulnerability prediction is based on signal probabilities (SPs) of a small set of flip-flops, chosen at design time, by studying the correlation between the soft-error vulnerability and the flip-flop SPs for representative workloads. We exploit machine learning to develop a predictive model that can be deployed in the system in software form. Simulation results on two processor designs show that the proposed technique can accurately estimate the soft-error vulnerability of on-chip logic core, such as sequential pipeline logic and functional units as well as memory arrays that constitute the instruction cache, the data cache, and the register file.
Patients with cancer holding their own records: a randomised controlled trial.

BACKGROUND The burden of cancer care in general practice is increasing. Patient-held records may facilitate effective, coordinated care, but no randomised controlled trials of their use in cancer care have been conducted, and concerns about possible negative effects remain. AIM To evaluate the use of a supplementary patient-held record in cancer care. METHOD Six hundred and fifty radiotherapy outpatients with any form of cancer were randomised either to hold a supplementary record or to receive normal care. It was explained to record holders that the supplementary record was intended to improve communication with health professionals and act as an aide memoire. After three months, patients' satisfaction with communication and with participation in their own care were assessed. Global health status, emotional functioning, and cognitive functioning were measured using the European Organization for Research and Treatment of Cancer QLQ-C30 questionnaire. RESULTS There were no significant differences between groups in any of the outcome measures. Patients in both groups expressed a high level of satisfaction with communication and participation in their care. Mean (SD) scores in the intervention and control groups were: global health status, 66.8 (24.2) and 65.3 (23.7); emotional functioning, 75.0 (24.6) and 77.4 (22.8); cognitive functioning, 84.5 (21.0) and 84.0 (21.3). CONCLUSION A supplementary patient-held record for radiotherapy outpatients appears to have no effect on satisfaction with communication, participation in care, or quality of life.
Unravelling the Complexity of T Cell Abnormalities in Common Variable Immunodeficiency1

We investigated several phenotypic and functional parameters of T cell-mediated immunity in a large series of common variable immunodeficiency (CVID) patients. We demonstrated that the vast majority of CVID patients presented multiple T cell abnormalities intimately related among them, the severity of which was reflected in a parallel loss of CD4+ naive T cells. A strong correlation between the number of CD4+ naive T cells and clinical features was observed, supporting the subgrouping of patients according to their number of naive CD4+ T lymphocytes. A reduced thymic output and disrupted CD4+ and CD8+ TCR repertoires paralleled the contraction of CD4+ naive T cell pools. The evaluation of activation markers and cytokine production indicated a strong T cell activation that was significantly related to the increased levels of T cell turnover and apoptosis. Finally, discrete genetic profiles could be demonstrated in groups of patients showing extremely diverse T cell subset composition and function. Naive CD4+ T cell levels were significantly associated with the switched memory B cell-based classification, although the concordance between the respective subgroups did not exceed 58.8%. In conclusion, our data highlight the key role played by the T cell compartment in the pathogenesis of CVID, pointing to the need to consider this aspect for classification of this disease.