Miracle-dz/UniFAR-FTUs huggingface dataset:
Dentine bond strength and microleakage of flowable composite, compomer and glass ionomer cement.

BACKGROUND To assess in vitro the dentine bond strength and microleakage of three Class V restorations viz. flowable composite, compomer and glass ionomer cement. METHODS Eighteen dentine specimens were prepared and randomly distributed among three groups. Three kinds of restoration materials were each bonded on prepared dentine surfaces in three groups as per the manufacturers' instructions. Group Aelite: Tyrian SPE (a no-rinse, self-priming etchant) + One Step Plus (an universal dental adhesive) + Aeliteflo (a flowable composite); Group Dyract: Prime & Bond NT (a no-rinse, self-priming dental adhesive) + Dyract AP (a compomer); Group GlasIonomer: GlasIonomer Type II (a self-cured restorative glass ionomer). Fifteen dentine/restoration microtensile bond test specimens were prepared from each group and were subjected to microtensile bond strength testing. The bond interfaces were observed morphologically using a scanning electron microscope (SEM). Twenty-four cervical cavities of 4.0 mm mesiodistal length, 2.0 mm occlusogingival height and 1.5 mm depth were prepared at the cemento-enamel junction (CEJ) on both buccal and lingual surfaces of each tooth. The cavities were each filled with flowable composite (Group Aelite), compomer (Group Dyract) and glass ionomer cement (Group GlasIonomer) using the same material and methods as for the microtensile bond tests. Microleakage of each restoration was evaluated by the ratio of the length of methylene blue penetration along the tooth-restoration interface and the total length of the dentine cavity wall on the cut surface. RESULTS One-way ANOVA and least significant difference (LSD) tests revealed statistically significant differences among the dentine bond strength for Group Aelite (28.4 MPa), Group Dyract (15.1 MPa) and Group GlasIonomer (2.5 MPa). SEM images showed intimate adaptation in the restoration/dentine interfaces of Group Aelite and Group Dyract. All of the systems tested in this study presented microleakage. However, both Group Aelite (0.808) and Group Dyract (0.863) had significantly less microleakage than Group GlasIonomer (0.964). There were no statistically significant microleakage differences between Group Aelite and Group Dyract, and no statistically significant microleakage differences between the occlusal margin and gingival margin. CONCLUSIONS None of the systems tested in this study completely eliminated microleakage. However, both the flowable composite and compomer provided stronger dentine bond strengths and better margin sealing than the conventional glass ionomer cement. Occlusal forces exerted the same effects on microleakage of the occlusal margin and gingival margin in cervical cavities.
Pathophysiological Bases of Comorbidity: Traumatic Brain Injury and Post-Traumatic Stress Disorder.

The high rates of traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) diagnoses encountered in recent years by the United States Veterans Affairs Healthcare System have increased public awareness and research investigation into these conditions. In this review, we analyze the neural mechanisms underlying the TBI/PTSD comorbidity. TBI and PTSD present with common neuropsychiatric symptoms including anxiety, irritability, insomnia, personality changes, and memory problems, and this overlap complicates diagnostic differentiation. Interestingly, both TBI and PTSD can be produced by overlapping pathophysiological changes that disrupt neural connections termed the "connectome. " The neural disruptions shared by PTSD and TBI and the comorbid condition include asymmetrical white matter tract abnormalities and gray matter changes in the basolateral amygdala, hippocampus, and prefrontal cortex. These neural circuitry dysfunctions result in behavioral changes that include executive function and memory impairments, fear retention, fear extinction deficiencies, and other disturbances. Pathophysiological etiologies can be identified using experimental models of TBI, such as fluid percussion or blast injuries, and for PTSD, using models of fear conditioning, retention, and extinction. In both TBI and PTSD, there are discernible signs of neuroinflammation, excitotoxicity, and oxidative damage. These disturbances produce neuronal death and degeneration, axonal injury, and dendritic spine dysregulation and changes in neuronal morphology. In laboratory studies, various forms of pharmacological or psychological treatments are capable of reversing these detrimental processes and promoting axonal repair, dendritic remodeling, and neurocircuitry reorganization, resulting in behavioral and cognitive functional enhancements. Based on these mechanisms, novel neurorestorative therapeutics using anti-inflammatory, antioxidant, and anticonvulsant agents may promote better outcomes for comorbid TBI and PTSD.
Critique does not equate to rebellion: Positive deviance and entrepreneurial networking among small and medium enterprises in Uganda

This paper examines the relationship between positive deviance and entrepreneurial networking among small and medium enterprises (SMEs). Using a mixed method approach combined self-administered questionnaires and interview guide covering 228 SMEs in Uganda, the cross-sectional nature of this study revealed key nuances about SMEs. The research findings confirmed a significant positive relationship between positive deviance and entrepreneurial networking among SMEs in Uganda. The findings also revealed that: SME owner/ managers should create enabling environment for people with divergent views to interact with each other to innovate new practices, such as accessing resources from the networks; managers should initiate new policies for error management to allow employees room to learn from mistakes; managers should acquire new skills of leadership skills to manage and utilize the knowledge and skills of positive deviants. This research therefore contributes to existing scholarship by providing nuances in the study of positive deviance and entrepreneurial networking among SMEs in Uganda through employing a complexity approach that transcends previous academic focus on social network theory. Key words: positive deviance, entrepreneurial networking, small and medium enterprises (SMEs), complexity.
Face and object processing in autism spectrum disorders

The nature and extent of face‐processing impairments in individuals with autism spectrum disorder (ASD) remain contentious. The aim of this research study is to assess the face‐ and object‐processing performance of individuals with ASD compared with typically developing controls. Our hypothesis was that individuals with ASD would be significantly impaired on tests of face processing but show intact object processing. More specifically, we tested two competing hypotheses to explain face‐processing deficits: holistic hypothesis; second‐order configural hypothesis. Twenty‐six able adults with ASD and 26 intelligence quotient‐matched typically developing controls completed two computerized tests of face and object discrimination. In task 1, the first picture (faces or cars) in a pair was presented as quickly as 40 msec to test holistic processing. In task 2, the decision was whether pairs of faces or houses had been altered in terms of the features or the distance between the features (the second‐order configural properties). Individuals with ASD were impaired on all tests of face processing but showed intact object processing and the pattern of findings favored the holistic hypothesis. The heterogeneous pattern of performance in the clinical group showed that some individuals with ASD perform similarly to typically developing individuals in their face‐processing skills, whereas others are more accurate in object processing compared with face processing.
An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population.

We analyzed 85 urine samples of the general German population for human specific metabolites of phthalates. By that we avoided contamination with the parent phthalates being omnipresent in the environment and for the first time could deduce each individual's internal exposure to phthalates without contamination. Determined were the secondary metabolites mono(2-ethyl-5-hydroxyhexyl)phthalate (5OH-MEHP) and mono(2-ethyl-5-oxo-hexyl)phthalate (5oxo-MEHP) of di(2-ethylhexyl)phthalate (DEHP) and the primary monoester metabolites of DEHP, di-noctylphthalate (DnOP), di-n-butylphthalate (DnBP), butylbenzylphthalate (BBzP) and diethylphthalate (DEP). Based on these internal exposure values we calculated the daily intake of the parent phthalates using urinary metabolite excretion factors. For DEHP we determined a median intake of 13.8 micrograms/kg body weight/day and an intake at the 95th percentile of 52.1 micrograms/kg body weight/day. The tolerable daily intake (TDI) value settled by the EU Scientific Committee for Toxicity, Ecotoxicity and the Environment (CSTEE) is 37 micrograms/kg body weight/day. Twelve percent of the subjects (10 out of 85 samples) within our collective of the general population are exceeding this value. Thirty-one percent of the subjects (26 out of 85 samples) had values higher than the reference dose (RfD) of 20 micrograms/kg body weight/day of the U.S. Environmental Protection Agency (EPA). For DnBP, BBzP, DEP and DnOP intake values at the 95th percentile were 16.2, 2.5, 22.1 and 0.42 micrograms/kg body weight/day respectively. Our results unequivocally prove that the general German population is exposed to DEHP to a much higher extent than previously believed. This is of greatest importance for public health since DEHP is not only the most important phthalate with respect to its production, use, occurrence and omnipresence but also the phthalate with the greatest endocrine disrupting potency. DEHP is strongly suspected to be a developmental and reproductive toxicant. We are not aware of any other environmental contaminant for which the TDI and RfD are exceeded to such an extent within the general population. The transgressions of the TDI and RfD for DEHP are accompanied by considerable ubiquitous exposures to DnBP and BbzP, two phthalates under scrutiny for similar toxicological mechanisms.
Moderators in the relationship between social contact and psychological distress among widowed adults

Objectives: This study examines: (1) the effect of widowed persons’ frequency of contact with friends and relatives on their depressive and grief symptoms six months following spousal loss and (2) the extent to which the effects of social contact are contingent upon the degree of emotional support received from these relationships and the congruence between widowed persons’ preferred and actual levels of social contact. Method: Analyses are based on the Changing Lives of Older Couples (CLOC) study, a prospective study of a two-stage area probability sample of 1532 married men and women aged 65 or older. Depressive and grief symptoms, six months after spousal loss, were regressed on social contact, support, and congruence between preferred and actual social contact. Results: Frequency of contact did not have a significant influence on psychological distress when contextual factors are controlled. Social support and the incongruence between preferred and actual social contact were significantly associated with decreased psychological distress for several outcomes. As for the moderating effects of social support and incongruence on the link between social contact and distress, those who had high social contact and high social support experienced less anger and fewer intrusive thoughts than their counterparts; and those who had low social contact but preferred high social contact experienced greater anger. Conclusion: The findings highlight the importance of understanding the quality of widowed persons’ relationships as well as the congruence between their preferred and actual social contact.
Monitoring Urban Land Cover in Rome, Italy, and Its Changes by Single-Polarization Multitemporal SAR Images

This study contributes an assessment of the potential of single-polarization decametric synthetic aperture radar (SAR) images in classifying land cover within and around large urban areas and in monitoring their changes. The decision task is performed on a pixel basis and is carried out by supervised neural network algorithms fed by radar image features including backscattering intensity, coherence and textural parameters. Two configurations are considered: a short-term classification and change detection scheme intended for providing information in near-real time and a long-term scheme aimed at observing the urban changes at year time scales. We use a pair of interferometric images for the short-term case, while the long-term exercise utilizes two interferometric pairs and a fifth single acquisition. The images are acquired by the ERS SAR in late winter, spring and early summer over 836 square kilometers including Rome, Italy, and its surroundings. The accuracy of the short-term algorithm in discriminating seven types of surface is higher than 86%, while the accuracy of the long-term algorithm is beyond 88%. The many changes undergone by Rome from 1994 to 1999 have been identified by the postclassification comparison change detection procedure. The pixel-by-pixel analysis of the results has been carried out for a 160 square kilometers test area, obtaining a correct detection above 82% (less than 18% missed alarms and 0.3% false alarms).
Sea-bed acoustic parameters from dispersion analysis and transmission loss in the East China Sea

As a part of the Asian Seas International Acoustic Experiment (ASIAEX) in the East China Sea, sound propagation signals from wideband explosive sources were measured using a 32-element vertical line array. Measurements were made as a function of range in two perpendicular tracks. Sea-bed geoacoustic parameters based on a fluid half-space geoacoustic model (sound speed, density, and attenuation) are inverted from the sound propagation in the frequency range 100-500 Hz. The sea-bed sound speed and density were first derived from mode arrival time differences which were obtained using a spatial mode filtering technique. Sea-bed acoustic attenuation was subsequently estimated by comparing measured transmission loss with model results.
Availability of neurotransmitter glutamate is diminished when β‐hydroxybutyrate replaces glucose in cultured neurons

Ketone bodies serve as alternative energy substrates for the brain in cases of low glucose availability such as during starvation or in patients treated with a ketogenic diet. The ketone bodies are metabolized via a distinct pathway confined to the mitochondria. We have compared metabolism of [2,4‐13C]β‐hydroxybutyrate to that of [1,6‐13C]glucose in cultured glutamatergic neurons and investigated the effect of neuronal activity focusing on the aspartate–glutamate homeostasis, an essential component of the excitatory activity in the brain. The amount of 13C incorporation and cellular content was lower for glutamate and higher for aspartate in the presence of [2,4‐13C]β‐hydroxybutyrate as opposed to [1,6‐13C]glucose. Our results suggest that the change in aspartate–glutamate homeostasis is due to a decreased availability of NADH for cytosolic malate dehydrogenase and thus reduced malate–aspartate shuttle activity in neurons using β‐hydroxybutyrate. In the presence of glucose, the glutamate content decreased significantly upon activation of neurotransmitter release, whereas in the presence of only β‐hydroxybutyrate, no decrease in the glutamate content was observed. Thus, the fraction of the glutamate pool available for transmitter release was diminished when metabolizing β‐hydroxybutyrate, which is in line with the hypothesis of formation of transmitter glutamate via an obligatory involvement of the malate–aspartate shuttle.
The effect of audit committee attributes on compliance with IAS 24-related party disclosure

Purpose This paper aims to investigate the compliance with IAS 24 and possible audit committee attributes that can influence companies in Ghana to disclose related party (RP) information in their annual reports. Design/methodology/approach Different univariate tests and multivariate regressions have been used to examine the hypotheses. The sample includes 120 firm-year observations for the period 2013-2016. Findings The findings of the paper reveal that related party disclosure compliance is influenced by audit committee gender, audit committee independence and ownership concentration. Originality/value To the best of the author’s knowledge, there are no empirical studies that have addressed the effect of audit committee attributes on IAS 24 in Ghana and the second of such study in sub-Saharan Africa.
Craniofacial injuries from slip, trip, and fall accidents of children.

BACKGROUND Slips, trips (STs), and falls are frequent events in childhood. As a child is likely to impact head-first in these events, craniofacial injuries are the most common trauma. We retrospectively surveyed our experience with pediatric craniofacial injuries and investigated the distributions of wound type and injury site, severity, and mechanism. METHODS A total of 750 children sustaining craniofacial injuries resulting from STs and falls were enrolled in this study. Facial and cranial areas were delimited by an imaginary line extending between the ears and across the eyebrows. Soft-tissue injuries were classified into laceration, contusion, and abrasion. The Glasgow Coma Scale was used to assess the severity of brain injury. RESULTS Peak incidence of ST-type childhood craniofacial injury occurred at toddler age, whereas falls tended to occur when the children were younger than 1 year old; most of the patients were preschool. The home was the scene for 73% of the STs and 86% of the falls. Lacerations occurred more often in STs (67% vs. 25%), whereas contusions more often resulted from falls (64% vs. 27%). Most of the injuries were to the anterior head with a T-shaped distribution; however, over one third (37%) of the contusions were to the posterior area. Brain injury was absent or only mild in 98% of craniofacial injuries. Falls resulted in a significantly higher incidence of moderate-severe brain injury relative to STs. CONCLUSIONS Childhood craniofacial injuries resulting from STs are more prevalent than are those that were sustained in falls; however, the latter is associated with greater trauma morbidity. The incidence of childhood craniofacial injury appears to be associated with the level of development irrespective of event type. The home is a potentially dangerous environment for children, especially during the preschool years. Padding the hard, acutely angled surfaces of housing structures and furniture around children's activity zones is an effective method of reducing the risk of childhood craniofacial trauma. Serious or fatal head injuries will rarely occur as the result of a fall from furniture or stairs at home.
Effects of long-term fertilization of forest soils on potential nitrification and on the abundance and community structure of ammonia oxidizers and nitrite oxidizers.

Forest fertilization in British Columbia is increasing, to alleviate timber shortfalls resulting from the mountain pine beetle epidemic. However, fertilization effects on soil microbial communities, and consequently ecosystem processes, are poorly understood. Fertilization has contrasting effects on ammonia-oxidizing bacteria and archaea (AOB and AOA) in grassland and agricultural ecosystems, but there are no studies on AOB and AOA in forests. We assessed the effect of periodic (6-yearly application 200 kg N ha⁻¹) and annual (c. 75 kg N ha⁻¹) fertilization of lodgepole pine and spruce stands at five long-term maximum productivity sites on potential nitrification (PN), and the abundance and diversity of AOB, AOA and Nitrobacter and Nitrospira-like nitrite-oxidizing bacteria (NOB). Fertilization increased AOB and Nitrobacter-like NOB abundances at some sites, but did not influence AOA and Nitrospira-like NOB abundances. AOB and Nitrobacter-like NOB abundances were correlated with PN and soil nitrate concentration; no such correlations were observed for AOA and Nitrospira-like NOB. Autotrophic nitrification dominated (55–97%) in these forests and PN rates were enhanced for up to 2 years following periodic fertilization. More changes in community composition between control and fertilized plots were observed for AOB and Nitrobacter-like NOB than AOA. We conclude that fertilization causes rapid shifts in the structure of AOB and Nitrobacter-like NOB communities that dominate nitrification in these forests.
Transfer of Regulatory Properties from Tolerogenic to Proinflammatory Dendritic Cells via Induced Autoreactive Regulatory T Cells

Infectious tolerance is a term generally assigned to the process through which regulatory T cells (Tregs) transfer immunoregulatory properties to other T cells. In this study, we demonstrated that a similar process applies to human dendritic cells (DCs), albeit through a different mechanism. We induced and cloned proinsulin-specific Tregs using tolerogenic DCs and investigated mechanisms by which induced Ag-specific regulatory T cells (iaTregs) endorse the suppressive effects. iaTregs expressed FOXP3, programmed death-1, and membrane-bound TGF-β and upregulated IL-10 and CTLA-4 after stimulation with the cognate Ag. The iaTregs suppressed effector T cells only when both encountered the cognate Ags on the same APCs (linked suppression). This occurred independently of IL-10, TGF-β, programmed death-1, or CTLA-4. Instead, iaTregs used a granzyme B-mediated mechanism to kill B cells and monocytes, whereas proinflammatory DCs that resisted being killed were induced to upregulate the inhibitory receptors B7 (family) homolog 3 and ICOS ligand. These re-educated mature monocyte-derived dendritic cells (mDCs) suppressed effector T cells and induced IL-10–producing cells from the naive T cell pool. Our data indicated that human tolerogenic DCs confer infectious tolerance by inducing Ag-specific Tregs, which, in turn, re-educate proinflammatory mature DCs into DCs with regulatory properties.
Unions, Two-Tier Bargaining and Physical Capital Investment: Theory and Firm-Level Evidence from Italy

In this paper we present a search and matching model in which firms invest in sunk capital equipment. By comparing two wage setting scenarios, we show that a two-tier bargaining scheme, where a fraction of the salary is negotiated at firm level, raises the amount of investment per worker in the economy compared to a one-tier bargaining scheme, in which earnings are entirely negotiated at sectoral level. The model's main result is consistent with the positive correlation between investment per worker and the presence of a two-tier bargaining agreement that we find in a representative sample of Italian firms.