Miracle-dz/UniFAR-FTUs huggingface dataset:
Two Spirits in Man: An Essay in Biblical Exegesis

11 a 24 auch "in«l in der gleichen Bedeutung. Vgl. dazu S. Krauss, Griech. und lat. Lehnworter im Talmud, Midrasch und Targumim, Teil 11 (1899)5 171. In dem jiingst erschienenen Aufsatz von H. W. Kuhn: 'Das Reittier Jesu in der Einzugsgeschichte des Markusevangeliums' (£.jV. W. L (1959), 82-91) wird mit Recht darauf hingewiesen, daB TTCOAOS SeSenEvos in Marc. xi. 2 aus dem messianischen Verstandnis von Gen. xlix. 11 stammt, und daB schon die Markusperikope wichtige Motive aus Sach. ix. 9 verarbeitet hat. Eine altere Florilegientradition wird sichtbar, die das Markusevangelium in Auf bau und Wortlaut bestimmt hat. So muB die Fragestellung W. Bauers neu aufgenommen und zum Verstandnis des Markusevangelisten ausgebaut werden. Trotz aller hellenistischen Beziige des zweiten Evangelisten stoBen wir hier auf altere palastinisch-orientalische Grundlagen. Es empfiehlt sich nicht, auf die Evangelisten einen spezifisch christlichen Sprachgebrauch von TTCOAOS zuriickzufilhren (so H. W. Kuhn a. a. 0. S. 84 f.). Unter diesen Umstanden scheint es doch selbstverstandlich zu sein, daB im orientalischen und semitischen Griechisch der Begriff TTCOAOS ganz eindeutig den jungen, starken Esel meint, und daB ein Zusatz nicht unbedingt hinzutreten muB. Selbstverstandlich ist es nicht befremdend, wenn vielfach im Griechischen eine nahere Bestimmung, sei es ein Adjektiv oder ein Genitiv, hinzutreten, wie es auch in der Evangelieniiberlieferung geschieht. Seltsam ist, daB Matth. den Parallelismus membrorum des LXX Textes anders versteht, als man es erwartet. Ein Mann, der eine so ausgezeichnete rabbinische Bildung erworben hat, geht hier offenbar seinen eigenen Weg. OTTO MICHEL
The Effects of Cumulative Violence Clusters on Young Mothers’ School Participation

Using a cluster analysis approach with a sample of 205 young mothers recruited from community sites in an urban Midwestern setting, we examined the effects of cumulative violence exposure (community violence exposure, witnessing intimate partner violence, physical abuse by a caregiver, and sexual victimization, all with onset prior to age 13) on school participation, as mediated by attention and behavior problems in school. We identified five clusters of cumulative exposure, and found that the HiAll cluster (high levels of exposure to all four types) consistently fared the worst, with significantly higher attention and behavior problems, and lower school participation, in comparison with the LoAll cluster (low levels of exposure to all types). Behavior problems were a significant mediator of the effects of cumulative violence exposure on school participation, but attention problems were not.
On symplectic linearization of singular Lagrangian foliations

En esta tesis se estudia el problema de clasificacion de estructuras simplecticas definidas en un entorno de una orbita singular compacta de un sistema completamente integrable sobre una variedad simplectica para las cuales la foliacion determinada por la aplicacion momento es genericamente Lagrangiana, Dicha foliacion esta determinada por las orbitas de la distribucion generada por los gradientes simplecticos de las componentes de la aplicacion momento $F$. En dicho estudio suponemos que la aplicacion momento es una aplicacion propia y que la singularidad es no-degenerada en el sentido de Morse-Bolt. Los invariantes diferenciables para dicha foliacion vienen determinados por el rango de la orbita, el tipo de Williamson y un grupo "twisting" actuando sobre las componentes hiperbolicas. Dichos invariantes determinan un modelo lineal diferenciable para la foliacion. Bajo estas hipotesis demostramos que dadas dos estructuras simplecticas $/omega_1$ y $/omega_2$ para las cuales la foliacion es genericamente Lagrangiana son equivalentes en el sentido siguiente: existe un difeomorfismo definido en un entorno de la orbita singular compacta preservando la foliacion y enviando $/omega_1$ a $/omega_2$. En el caso en que exista una accion simplectica de un grupo de Lie compacto $G$ que conserva la aplicacion momento $F$, probamos que existe un difeomorfismo cumpliendo las condiciones anteriores y que ademas dicho difeomorfismo puede construirse de forma $G$-equivariante. En esta tesis tambien damos una aplicacion de este resultado de clasificacion en geometria de contacto. Consideramos una variedad de contacto para la cual el campo de Reeb admite $n$ integrales genericamente idenpendientes y conmutando respecto el parentesis de Jacobi y suponemos que dichas $n$ integrales determinan una aplicacion propia. Las componentes horizontales de los campos de vectores de contacto asociados a estas integrales, determin
Etiological profile of noncompressive myelopathies in a tertiary care hospital of Northeast India

Background: The discovery of antibodies against aquaporin-4 and evolving concepts of noncompressive myelopathies in the 21st century have made a major impact on the etiological profile of these diseases, with few cases turning out to be idiopathic. Objective: To find causes of noncompressive myelopathy in a tertiary care hospital of Northeast India. Materials and Methods: An observational study was carried out in the Neurology Department of Gauhati Medical College, Guwahati, from September 2013 to February 2016. Patients of noncompressive myelopathies who underwent magnetic resonance imaging (MRI) of the spine were segregated into two categories: acute-to-subacute myelopathy (ASM) and chronic myelopathy (CM). In addition to routine blood tests, chest X-ray, urinalysis, and visual evoked potentials, investigations included MRI of the brain, cerebrospinal fluid analysis, and immunological, infectious, and metabolic profile based on the pattern of involvement. Results: The study had 151 patients (96 ASM and 55 CM) with a median age of 35 years and male: female ratio 1.4:1. The causes of ASM were neuromyelitis optica spectrum disorder (23), multiple sclerosis (MS) (8), systemic lupus erythematosus (1), Hashimoto's disease (1), postinfectious acute disseminated encephalomyelitis (6), postinfectious myelitis (8), infections (9), spinal cord infarct (5), and electrocution (1). The causes of CM were MS (1), probable or possible sarcoidosis (7), mixed connective tissue disease (1), Hashimoto's disease (2), infections (9), Vitamin B12deficiency (4), folate deficiency (2), hepatic myelopathy (2), radiation (11), and paraneoplastic (1). No etiology could be found in 48 (31.8% ) patients (34 ASM and 14 CM). In 21/96 (21.9% ) patients of ASM, acute transverse myelitis was idiopathic based on current diagnostic criteria. Conclusion: Underlying etiology (demyelinating, autoimmune, infectious, vascular, metabolic disorder, or physical agent) was found in 68% patients of noncompressive myelopathy.
The Ghost of Christmas Past: health effects of poverty in London in 1896 and 1991

Abstract Objectives: To compare the extent to which late 20th century patterns of mortality in London are predicted by contemporary patterns of poverty and by late 19th century patterns of poverty. To test the hypothesis that the pattern of mortality from causes known to be related to deprivation in early life can be better predicted by the distribution of poverty in the late 19th century than by that in the late 20th century. Design: Data from Charles Booth's survey of inner London in 1896 were digitised and matched to contemporary local government wards. Ward level indices of relative poverty were derived from Booth's survey and the 1991 UK census of population. All deaths which took place within the surveyed area between 1991 and 1995 were identified and assigned to contemporary local government wards. Standardised mortality ratios for various causes of death were calculated for each ward for all ages, under age 65, and over age 65. Simple correlation and partial correlation analysis were used to estimate the contribution of the indices of poverty from 1896 and 1991 in predicting ward level mortality ratios in the early 1990s. Setting: Inner London. Results: For many causes of death in London, measures of deprivation made around 1896 and 1991 both contributed strongly to predicting the current spatial distribution. Contemporary mortality from diseases which are known to be related to deprivation in early life (stomach cancer, stroke, lung cancer) is predicted more strongly by the distribution of poverty in 1896 than that in 1991. In addition, all cause mortality among people aged over 65 was slightly more strongly related to the geography of poverty in the late 19th century than to its contemporary distribution. Conclusions: Contemporary patterns of some diseases have their roots in the past. The fundamental relation between spatial patterns of social deprivation and spatial patterns of mortality is so robust that a century of change in inner London has failed to disrupt it.
The transcriptional regulator megakaryoblastic leukemia‐1 mediates serum response factor‐independent activation of tenascin‐C transcription by mechanical stress

The extracellular matrix protein tenascin‐C (TNC) is up‐regulated in processes influenced by mechanical stress, such as inflammation, tissue remodeling, wound healing, and tumorigenesis. Cyclic strain‐induced TNC expression depends on RhoA‐actin signaling, the pathway that regulates transcriptional activity of serum response factor (SRF) by its coactivator megakaryoblastic leukemia‐1 (MKL1). Therefore, we tested whether MKL1 controls TNC transcription. We demonstrate that overexpression of MKL1 strongly induces TNC expression in mouse NIH3T3 fibroblasts and normal HC11 and transformed 4T1 mammary epithelial cells. Part of the induction was dependant on SRF and a newly identified atypical CArG box in the TNC promoter. Another part was independent of SRF but required the SAP domain of MKL1. An MKL1 mutant incapable of binding to SRF still strongly induced TNC, while induction of the SRF target c‐fos was abolished. Cyclic strain failed to induce TNC in MKL1‐deficient but not in SRF‐deficient fibroblasts, and strain‐induced TNC expression strongly depended on the SAP domain of MKL1. Promoter‐reporter and chromatin immunoprecipitation experiments unraveled a SAP‐dependent, SRF‐independent interaction of MKL1 with the proximal promoter region of TNC, attributing for the first time a functional role to the SAP domain of MKL1 in regulating gene expression. —Asparuhova, M. B. , Ferralli, J., Chiquet, M. , Chiquet‐Ehrismann, R. The transcriptional regulator megakaryoblastic leukemia‐1 mediates serum response factor‐independent activation of tenascin‐C transcription by mechanical stress. FASEB J. 25, 3477–3488 (2011). www.fasebj. org
Scanning the human proteome for calmodulin-binding proteins

The calcium ion (Ca2+) is a ubiquitous second messenger that is crucial for the regulation of a wide variety of cellular processes. The diverse transient signals transduced by Ca2+ are mediated by intracellular Ca2+-binding proteins, also known as Ca2+ sensors. A key obstacle to studying many Ca2+-sensing proteins is the difficulty in identifying the numerous downstream target interactions that respond to Ca2+-induced conformational changes. Among a number of Ca2+ sensors in the eukaryotic cell, calmodulin (CaM) is the most widespread and the best studied. Employing the mRNA display technique, we have scanned the human proteome for CaM-binding proteins and have identified and characterized a large number of both known and previously uncharacterized proteins that interact with CaM in a Ca2+-dependent manner. The interactions of several identified proteins with Ca2+/CaM were confirmed by using pull-down assays and coimmunoprecipitation. Many of the CaM-binding proteins identified belong to protein families such as the DEAD/H box proteins, ribosomal proteins, proteasome 26S subunits, and deubiquitinating enzymes, suggesting the possible involvement of Ca2+/CaM in different signaling pathways. The selection method described herein could be used to identify the binding partners of other calcium sensors on the proteome-wide scale.
Amorphism and Physicochemical Stability of Spray‐dried Frusemide

Abstract— The physicochemical properties of amorphous forms of frusemide, prepared by spray‐drying at 50 or 150°C, and their hygroscopic stability at temperatures of 25 and 40°C, and at 0 and 75% relative humidity were investigated. The glass transition temperature of the amorphous form A was 44·2°C as measured by differential scanning calorimetry, while that of the amorphous form B was 54·4°C. The activation energies for glass transition and crystallization processes were calculated from the differential scanning calorimetry thermograms of amorphous forms A and B, respectively. Stability determined by X‐ray diffraction at 0% relative humidity, 25 and 40°C suggested that form B was more stable than form A. However, the stability of form A at 75% relative humidity and 25 and 40°C was similar to that of form B.
Importation and Recombination Are Responsible for the Latest Emergence of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus in China

ABSTRACT In China, a majority of the highly pathogenic porcine reproductive and respiratory syndrome (HP-PRRSV) strains were seeded by the 2006 outbreak. However, the most recently emerged (2013-2014) HP-PRRSV strain has a very different genetic background. It is a NADC30-like PRRSV strain recently introduced from North America that has undergone genetic exchange with the classic HP-PRRSV strains in China. Subsequent isolation and characterization of this variant suggest high pathogenicity, so it merits special attention in control and vaccine strategies.
The Educational Bias in Commuting Patterns: Micro-Evidence for the Netherlands

This study analyses the relation between education and commuting behaviour of Dutch workers. Results show that, ceteris paribus, higher educated workers commute further, both in terms of distance and time. In addition, higher educated workers are more frequent users of public transport and of bicycles. Furthermore, we find that higher educated workers are relatively more likely to commute towards agglomerated areas and areas that pay relatively high wages, while they are more likely to live in and commute from areas with higher land rents.
Weighing the value of memory loss in the surgical evaluation of left temporal lobe epilepsy: A decision analysis

Anterior temporal lobectomy is curative for many patients with disabling medically refractory temporal lobe epilepsy, but carries an inherent risk of disabling verbal memory loss. Although accurate prediction of iatrogenic memory loss is becoming increasingly possible, it remains unclear how much weight such predictions should have in surgical decision making. Here we aim to create a framework that facilitates a systematic and integrated assessment of the relative risks and benefits of surgery versus medical management for patients with left temporal lobe epilepsy.
A Novel Motion-Onset N200\P300 Brain-Computer Interface Paradigm*

The event related potential (ERP) component P300 and N200 are considered to be the most valuable electrophysiological indicators to reflect cognitive function. The traditional rare-event P300-BCI paradigm usually only takes P300 component as the target feature but ignores the N200 component. In this paper, we proposed a novel motion-onset N200\P300 brain-computer interface (BCI) paradigm, which could evoke significant N200 and P300 responses simultaneously. To evaluate the practicality of the proposed novel BCI paradigm and the robustness of the evoked N200\P300 components, three different classifiers of linear discriminant analysis (LDA), stepwise linear discriminant analysis (SWLDA) and support vector machine (SVM) with different algorithm principles were used to analyze the recognition accuracy. We also compared the motion-onset N200\P300 data with an N200-free portion to evaluate the impact of N200 component on the improvement of the BCI accuracy. Experimental results showed that, by means of this N200\P300 combination feature, the BCI accuracy significantly increased and the false positive rate significantly decreased, indicating that the proposed motion-onset N200\P300 BCI paradigm has superior performance than a traditional P300-BCI paradigm.
Ammonia binding to the oxygen-evolving complex of photosystem II identifies the solvent-exchangeable oxygen bridge (μ-oxo) of the manganese tetramer

The assignment of the two substrate water sites of the tetra-manganese penta-oxygen calcium (Mn4O5Ca) cluster of photosystem II is essential for the elucidation of the mechanism of biological O-O bond formation and the subsequent design of bio-inspired water-splitting catalysts. We recently demonstrated using pulsed EPR spectroscopy that one of the five oxygen bridges (μ-oxo) exchanges unusually rapidly with bulk water and is thus a likely candidate for one of the substrates. Ammonia, a water analog, was previously shown to bind to the Mn4O5Ca cluster, potentially displacing a water/substrate ligand [Britt RD, et al. (1989) J Am Chem Soc 111(10):3522–3532]. Here we show by a combination of EPR and time-resolved membrane inlet mass spectrometry that the binding of ammonia perturbs the exchangeable μ-oxo bridge without drastically altering the binding/exchange kinetics of the two substrates. In combination with broken-symmetry density functional theory, our results show that (i) the exchangable μ-oxo bridge is O5 {using the labeling of the current crystal structure [Umena Y, et al. (2011) Nature 473(7345):55–60]}; (ii) ammonia displaces a water ligand to the outer manganese (MnA4-W1); and (iii) as W1 is trans to O5, ammonia binding elongates the MnA4-O5 bond, leading to the perturbation of the μ-oxo bridge resonance and to a small change in the water exchange rates. These experimental results support O-O bond formation between O5 and possibly an oxyl radical as proposed by Siegbahn and exclude W1 as the second substrate water.
Use of the Airtraq laryngoscope in a model of difficult intubation by prehospital providers not previously trained in laryngoscopy

This study evaluated the ability of prehospital providers who had no previous training in intubation, to use an Airtraq laryngoscope to intubate a manikin model of a Cormack and Lehane grade III/IV view. Volunteers attending the Australian College of Ambulance Professionals conference, Adelaide, in November 2006 received approximately 5 min of Airtraq training. First‐time intubation success rate was 26/33 (79%) (95% CI 61–91%); oesophageal intubation rate was 0/33 (0%) (95% CI 0–11%); median time to intubation was 17 s (IQR 10–25 s (range 5–30 s)); and median subject‐rated difficulty of use score was 21 out of a maximum of 100 (IQR 7.5–35.5 (range 1–65)). Pre‐hospital providers without previous laryngoscopy training achieved high first‐time intubation success rates when managing a model of a grade III/IV difficult intubation with an Airtraq laryngoscope. Users evaluated it as easy to use and achieved intubation within an acceptable breath‐to‐breath interval.
Mutation spectrum of the connexin 26 (GJB2) gene in Taiwanese patients with prelingual deafness

Purpose: To determine the mutation spectrum of the connexin 26 gene among 324 Taiwanese patients with prelingual deafness and the carrier rate of gene mutation in another 432 unrelated control subjects.Methods: The coding region of the connexin 26 gene was sequenced in both directions to detect mutation in all 756 samples.Results: Among the 756 samples tested, 21 connexin 26 variants were detected, including 7 novel ones. The 235delC mutation was the most common, accounting for 57.6% of the mutant alleles. Among patients, 48 (14.8%) had connexin 26 gene mutations. In the control group, the carrier rate of connexin 26 mutation was estimated at 2.8%. Conclusion: The mutation spectrum of the connexin 26 gene is wide, with more than half of the patients having only one mutation detected. Thus, further efforts are needed to look for possible existence of a second mutant allele.
Direct molecular dynamics simulation of flow down a chemical potential gradient in a slit-shaped micropore.

A novel nonequilibrium molecular dynamics simulation technique has been developed whereby the flux of particles, flowing between explicitly defined regions of different constant chemical potential, is measured directly by counting particles. The method uses both stochastic and dynamic steps. A linear relationship between flux and concentration gradient (Fick's law) is found for methane in a carbonaceous slit micropore with a diffuse wall condition. Diffusion coefficients thereby calculated are larger than transport diffusivities from equilibrium simulations using Darken's rule.
Informing Pedagogical Action

This article considers the developing field of learning analytics and argues that to move from small-scale practice to broad scale applicability, there is a need to establish a contextual framework that helps teachers interpret the information that analytics provides. The article presents learning design as a form of documentation of pedagogical intent that can provide the context for making sense of diverse sets of analytic data. We investigate one example of learning design to explore how broad categories of analytics—which we call checkpoint and process analytics—can inform the interpretation of outcomes from a learning design and facilitate pedagogical action.
An Optimization Model for Efficient Energy Exchange in Energy Communities

In recent years, the distribution of local and renewable generation plants has introduced significant challenges in the management of electrical energy. In order to increase the usage of renewable energy, prosumers, i.e., users that can act both as producers and consumers, can benefit from joining together and forming energy communities. This new scenario calls for great research investigations aimed to improve the management of energy exchanges inside energy communities In particular, efficient solutions need to consider the interaction among several energy entities, among which distributed renewable plants, residential loads and energy storage systems. In this paper, an optimazation model for the energy management in energy communities is presented. The novelty consists in modeling the entire energy community as a whole, rather than each prosumer separately, with the goal of optimizing the energy sharing and balance at the community level. Experimental results, performed in an university campus, show the advantages of the approach and its capability of reducing the energy costs and increasing the community's energy autonomy.