Miracle-dz/UniFAR-FTUs huggingface dataset:
RockFS: Cloud-backed File System Resilience to Client-Side Attacks

Cloud-backed file systems provide on-demand, high-availability, scalable storage. Their security may be improved with techniques such as erasure codes and secret sharing to fragment files and encryption keys in several clouds. Attacking the server-side of such systems involves penetrating one or more clouds, which can be extremely difficult. Despite all these benefits, a weak side remains: the client-side. The client devices store user credentials that, if stolen or compromised, may lead to confidentiality, integrity, and availability violations. In this paper we propose RockFS, a cloud-backed file system framework that aims to make the client-side of such systems resilient to attacks. RockFS protects data in the client device and allows undoing unintended file modifications.
A phase 2 trial of abiraterone acetate without glucocorticoids for men with metastatic castration‐resistant prostate cancer

Abiraterone acetate suppresses adrenal androgens and glucocorticoids through the inhibition of CYP17; however, given the risk of mineralocorticoid excess, it is administered with glucocorticoids. Herein, the authors performed a phase 2, single‐arm study that was designed to assess the safety of abiraterone acetate without steroids in patients with castration‐resistant prostate cancer.
Treatment patterns, duration and outcomes of pemetrexed maintenance therapy in patients with advanced NSCLC in a real-world setting

Abstract Objectives: In patients with non-squamous non-small-cell lung cancer (NSCLC), maintenance therapy regimens, including pemetrexed, have been shown to prolong overall survival (OS) and progression-free survival (PFS). The purpose of this study was to describe real-world maintenance use of pemetrexed and associated outcomes in patients with advanced NSCLC. Methods: This was a retrospective, observational study that used longitudinal, demographically and geographically diverse electronic health record data in the United States. Eligible patients were adults with advanced non-squamous NSCLC who had received maintenance treatment with pemetrexed monotherapy or pemetrexed plus bevacizumab. Descriptive statistics were used to describe the patient population and multivariable logistic regression was used to identify the factors associated with duration of maintenance therapy. Kaplan–Meier curves and Cox regression models were used for time-to-event analysis. Results: Patients receiving pemetrexed maintenance therapy were treated with either pemetrexed monotherapy (66.0%) or pemetrexed plus bevacizumab (34.0%). Carboplatin and pemetrexed (37.9%) or carboplatin, pemetrexed and bevacizumab (36.1%) were the most commonly used first-line therapies observed. The majority (84.9%) of these maintenance patients responded to first-line therapy. The median duration of maintenance therapy was 6.0 months for pemetrexed and bevacizumab and 4.1 months for pemetrexed monotherapy. The median OS from the start of first-line therapy of the total study cohort was 21.5 months (95% CI 20.0, 22.9). Conclusion: Real-world effectiveness of pemetrexed maintenance therapy is similar to that observed in published randomized controlled trials, confirming a role for pemetrexed maintenance in eligible patients in clinical practice.
Stroke recurrence in the different subtypes of ischemic stroke. The importance of the intracranial disease

ABSTRACT The aim of the study was to analyze the long-term recurrence rate in patients with a first-ever ischemic stroke secondary to intracranial large artery atherosclerosis (LAA) in a Brazilian population. Methods: All stroke patients admitted to the hospital between October 2012 and September 2015 were evaluated. The stroke mechanism subtypes were classified as cardioembolism, LAA, small-vessel occlusion, other determined etiologies, and stroke of undetermined etiology. Results: The 359 first-ever ischemic stroke patients were followed up for a mean time of 21.6 ± 15.1 months. The LAA intracranial (38.9%) and extracranial (24.6%) stroke patients presented with a higher stroke recurrence. Intracranial LAA [HR, 10.2 (3.6–29.1); p < 0.001] and extracranial LAA [HR, 5.05 (1.79–14.2); p = 0.002] were the only conditions to show positive correlation with the recurrence rate, after adjusting for risk factors, thrombolysis, and National Institutes of Health Stroke Scale score at admission. Conclusion: Intracranial LAA presents a higher incidence of recurrence of ischemic stroke when compared with other etiologies in a Southern Brazilian population.
Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer

Skeletal metastasis occurs in around 75% of advanced breast cancers, with the disease incurable once cancer cells disseminate to bone, but there remains an unmet need for biomarkers to identify patients at high risk of bone recurrence. This study aimed to identify such a biomarker and to assess its utility in predicting response to adjuvant zoledronic acid (zoledronate). We used quantitative proteomics (stable isotope labelling by amino acids in cell culture‐mass spectrometry; SILAC‐MS) to compare protein expression in a bone‐homing variant (BM1) of the human breast cancer cell line MDA‐MB‐231 with parental non‐bone‐homing cells to identify novel biomarkers for risk of subsequent bone metastasis in early breast cancer. SILAC‐MS showed that dedicator of cytokinesis protein 4 (DOCK4) was upregulated in bone‐homing BM1 cells, confirmed by western blotting. BM1 cells also had enhanced invasive ability compared with parental cells, which could be reduced by DOCK4‐shRNA. In a training tissue microarray (TMA) comprising 345 patients with early breast cancer, immunohistochemistry followed by Cox regression revealed that high DOCK4 expression correlated with histological grade (p = 0.004) but not oestrogen receptor status (p = 0.19) or lymph node involvement (p = 0.15). A clinical validation TMA used tissue samples and the clinical database from the large AZURE adjuvant study (n = 689). Adjusted Cox regression analyses showed that high DOCK4 expression in the control arm (no zoledronate) was significantly prognostic for first recurrence in bone (HR 2.13, 95%CI 1.06–4.30, p = 0.034). No corresponding association was found in patients who received zoledronate (HR 0.812, 95%CI 0.176–3.76, p = 0.790), suggesting that treatment with zoledronate may counteract the higher risk for bone relapse from high DOCK4‐expressing tumours. High DOCK4 expression was not associated with metastasis to non‐skeletal sites when these were assessed collectively. In conclusion, high DOCK4 in early breast cancer is significantly associated with aggressive disease and with future bone metastasis and is a potentially useful biomarker for subsequent bone metastasis risk. Copyright © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
When Words Fail: Collaborative Gestures During Clarification Dialogues

Research on co-speech gestures has primarily focussed on speakers. However, in conversation non-speaking addressees can also gesture. Often this is to provide concurrent feedback such as backchannels but sometimes it involves gestures that relate to the specific content of the speaker’s turn. We hypothesise that nonspeakers should contribute most actively during clarification sequences i.e. at the moments when mutualunderstanding is threatened. We test this hypothesis using a corpus of story-telling dialogues, captured using video and motion capture. The results show that during clarification sequences speaker and non-speaker behaviours tend to merge. Non-speakers in particular move their hands faster and produce more than twice as many content-specific specific gestures in overlap with speaker turns. These results underline the collaborative nature of conversation, the strategic importance of nonverbal resources for sustaining mutual-understanding and the critical role of clarification and repair in successful communication.
Building and applying geographical information system Grids

We discuss the development and application of Web‐service‐based geographical information system (GIS) Grids. Following the WS‐I+ approach of building Grids on Web service standards, we have developed data Grid components for archival and real‐time data, map generating services that can be used to build user interfaces, information services for storing both stateless and stateful metadata, and service orchestration and management tools. Our goal is to support dynamically assembled Grid service collections that combine both GIS services with more traditional Grid capabilities such as file transfer and remote code execution. We are applying these tools to problems in earthquake modeling and forecasting, but we are attempting to build general purpose tools by using and extending appropriate standards. Copyright © 2008 John Wiley & Sons, Ltd.
Memory Capacity of Networks with Stochastic Binary Synapses

In standard attractor neural network models, specific patterns of activity are stored in the synaptic matrix, so that they become fixed point attractors of the network dynamics. The storage capacity of such networks has been quantified in two ways: the maximal number of patterns that can be stored, and the stored information measured in bits per synapse. In this paper, we compute both quantities in fully connected networks of N binary neurons with binary synapses, storing patterns with coding level , in the large and sparse coding limits (). We also derive finite-size corrections that accurately reproduce the results of simulations in networks of tens of thousands of neurons. These methods are applied to three different scenarios: (1) the classic Willshaw model, (2) networks with stochastic learning in which patterns are shown only once (one shot learning), (3) networks with stochastic learning in which patterns are shown multiple times. The storage capacities are optimized over network parameters, which allows us to compare the performance of the different models. We show that finite-size effects strongly reduce the capacity, even for networks of realistic sizes. We discuss the implications of these results for memory storage in the hippocampus and cerebral cortex.
A scoping review of metamodeling applications and opportunities for advanced health economic analyses

ABSTRACT Introduction: Metamodels, also known as meta-models, surrogate models, or emulators, are used in several fields of research to negate runtime issues with analyzing computational demanding simulation models. This study introduces metamodeling and presents results of a review on metamodeling applications in health economics. Areas covered: A scoping review was performed to identify studies that applied metamodeling methods in a health economic context. After search and selection, 13 publications were found to employ metamodeling methods in health economics. Metamodels were used to perform value of information analysis (n = 5, 38%), deterministic sensitivity analysis (n = 4, 31%), model calibration (n = 1, 8%), probabilistic sensitivity analysis (n = 1), or optimization (n = 1, 8%). One study was found to extrapolate a simulation model to other countries (n = 1, 8%). Applied metamodeling techniques varied considerably between studies, with linear regression being most frequently applied (n = 7, 54%). Expert commentary: Although it has great potential to enable computational demanding analyses of health economic models, metamodeling in health economics is still in its infancy, as illustrated by the limited number of applications and the relatively simple metamodeling methods applied. Comprehensive guidance specific to health economics is needed to provide modelers with the information and tools needed to utilize the full potential of metamodels.
Using Risk Communication Strategies for Zika Virus Prevention and Control Driven by Community-Based Participatory Research

Background: In this study, we use community-based participatory processes to engage community and academic partners in a meaningful exchange to identify and pilot test risk communication strategies for Zika virus prevention and control. Methods: Community members were actively involved in planning, developing, and implementing a risk communication initiative. Qualitative and quantitative data gathered through individual interviews, focus groups, and community advisory board input provided information for the identification of relevant risk communication strategies to increase the understanding about Zika virus and to promote behavior change. To examine its impact we obtained baseline and follow-up data from a random sample of 75 community residents. A face-to-face interview was conducted to assess community members’ knowledge, attitudes, and behaviors regarding Zika virus infection. Results: Study activities focused on three risk communication strategies: Zika awareness health fair, health education through theater, and community forums and workshops. The risk communication initiative was implemented over a two-month period. Findings from baseline and follow-up data demonstrated significant positive changes in respondents’ recognition of personal and community responsibility for the prevention of Zika infection, increased knowledge of prevention strategies, and enhanced engagement in preventive behaviors for mosquito control. Conclusion: Our findings sustain the benefits of community based participatory research for the design and implementation of risk communication strategies that are relevant to enable residents in low-income communities to take informed decisions for the protection against Zika virus and other mosquito-borne diseases.
Interactions between recreational cannabis use and cognitive function: lessons from functional magnetic resonance imaging

Cannabis use is becoming increasingly popular as a growing number of states pass legislation to legalize cannabis and cannabis‐derived products for recreational and/or medical purposes. Given the widespread use of cannabis, it is critical to understand the neural consequences related to cannabis use. In this review, we focus on evidence from functional magnetic resonance imaging studies that document acute and residual alterations in brain function during tasks spanning a variety of cognitive domains: executive function, attention and working memory, memory, motor skills, error monitoring, and reward and affective processing. Although it is clear that cannabis affects brain function, the findings are somewhat inconsistent; variables that potentially affect study outcomes are outlined, including a discussion of the impact of chronological age and age of cannabis onset as well as length of abstinence at the time of assessment, which are important considerations when measuring cannabis use patterns. Inherent differences between recreational/adult cannabis use versus use for medical purposes are also discussed, given their importance to public policy decisions.
What is it like to have your loved one with a severe brain injury come to rehabilitation? The experiences of significant others

Abstract Purpose: To investigate the experiences of significant others when their loved one with a severe brain injury is admitted to acquired brain injury (ABI) rehabilitation. Main measures: A qualitative approach was undertaken; using in-depth interviews and the drawing method to elicit information on the experiences of significant others who had loved ones enter an ABI unit, early in the sub-acute rehabilitation admission. Results: Nine significant others participated in interviews and completed drawings. Seven themes were identified from the two sources of data. Themes included: Trauma; Relief; Interactions; Change; Grief and loss; Journey, and Uncertainty. Conclusions: The whole experience for the significant other is traumatic as they try to understand changes to both their loved ones and their own roles. Healthcare providers have a key role in supporting significant others as their loved ones enter rehabilitation. The role of the drawing method appears to supplement and extend data received from interviews, shedding additional light into the lived experiences of significant others of those with an acquired brain injury. Implications for rehabilitation Early in the rehabilitation process, significant others experience emotional trauma resulting from their experience of their loved one’s trauma. It is important that health professionals interactions with significant others are respectful and kind, and that interactions around processes and communication are clear. Expertise and a tailored environment reduce stress and increase feelings of confidence in significant others. Significant others may need time to talk about their experiences with health professional staff, to support them to adjust to this major life change.
Hybrid Reasoning for Teams of Heterogeneous Robots: Finding an Optimal Feasible Global Plan

We address two key challenges of domains including teams of heterogeneous robots, hybrid reasoning for each team and finding an optimal global plan for multiple teams, by utilizing state-of-the-art automated reasoners. For hybrid reasoning, we propose (i) representing each team’s workspace taking into account capabilities of heterogeneous robots, (ii) combining different methods of integration to embed external computations (e.g., collision checks) into high-level representation and reasoning, (iii) further optimizing local feasible shortest plans by minimizing the total cost of robotic actions, where costs of actions can be defined in various ways. To find a shortest global plan, we propose a semi-distributed approach based on our earlier studies: we formulate the problem of finding an optimal coordination of teams that can help each other, prove its intractability, and describe how to solve this problem using automated reasoners. As a case study, we have formally represented a cognitive toy factory and showed an application of our hybrid reasoning and coordination approach on this domain. We have performed dynamic simulations and physical implementation of the cognitive toy factory utilizing KuKa youBots and Lego NXT robots.
Phosphatidylinositol 4‐phosphate on Rab7‐positive autophagosomes revealed by the freeze‐fracture replica labeling

Phosphatidylinositol 4‐phophate (PtdIns(4)P) is an essential signaling molecule in the Golgi body, endosomal system, and plasma membrane and functions in the regulation of membrane trafficking, cytoskeletal organization, lipid metabolism and signal transduction pathways, all mediated by direct interaction with PtdIns(4)P‐binding proteins. PtdIns(4)P was recently reported to have functional roles in autophagosome biogenesis. LC3 and GABARAP subfamilies and a small GTP‐binding protein, Rab7, are localized on autophagosomal membranes and participate at each stage of autophagosome formation and maturation. To better understand autophagosome biogenesis, it is essential to determine the localization of PtdIns(4)P and to examine its relationship with LC3 and GABARAP subfamilies and Rab7. To analyze PtdIns(4)P distribution, we used an electron microscopy technique that labels PtdIns(4)P on the freeze‐fracture replica of intracellular biological membranes, which minimizes the possibility of artificial perturbation because molecules in the membrane are physically immobilized in situ. Using this technique, we found that PtdIns(4)P is localized on the cytoplasmic, but not the luminal (exoplasmic), leaflet of the inner and outer membranes of autophagosomes. Double labeling revealed that PtdIns(4)P mostly colocalizes with Rab7, but not with LC3B, GABARAP, GABARAPL1 and GABARAPL2. Rab7 plays essential roles in autophagosome maturation and in autophagosome‐lysosome fusion events. We suggest that PtdIns(4)P is localized to the cytoplasmic leaflet of the autophagosome at later stages, which may illuminate the importance of PtdIns(4)P at the later stages of autophagosome formation.
On the Frequency Response of Nanostructured Thermoacoustic Loudspeakers

In this work, we investigate the thermal and acoustic frequency responses of nanostructured thermoacoustic loudspeakers. An opposite frequency dependence of thermal and acoustic responses was found independently of the device substrate (Kapton and glass) and the nanometric active film (silver nanowires and nm-thick metal films). The experimental results are interpreted with the support of a comprehensive electro-thermo-acoustic model, allowing for the separation of the purely thermal effects from the proper thermoacoustic (TA) transduction. The thermal interactions causing the reported opposite trends are understood, providing useful insights for the further development of the TA loudspeaker technology.
Contrôle du regard: mécanismes et substrats neuronaux de l'adaptation des mouvements oculaires saccadiques chez l'homme

" - Comment apprecions-nous la complexite du monde qui nous entoure ? - En bougeant nos yeux ! - Pourquoi ? - Parce qu'une perception visuelle efficace (avec une acuite maximale ! ) necessite de placer l'image des elements pertinents du champ visuel au niveau d'une petite partie de notre retine : la fovea. " Les saccades oculaires sont les mouvements les plus rapides que peut produire notre organisme et sont malgre tout tres precises. Le controle de ces mouvements represente un defi pour notre cerveau. En effet, ces saccades sont tellement rapides qu'aucune information visuelle ne peut modifier leur trajectoire en cours d'execution. Mais alors, de quels moyens dispose notre cerveau pour maintenir ces performances tout au long de notre vie? En cas d'imprecision repetee, des mecanismes vont progressivement modifier l'amplitude de nos saccades oculaires afin d'en retablir la precision. Cette adaptation saccadique repose sur des modifications centrales plastiques. Ce travail de these a comme vocation d'elucider les caracteristiques de l'adaptation saccadique chez l'homme. Des approches complementaires ont permis d'etudier d'une part, l'adaptation des deux grandes categories de saccades, reactives et volontaires, et d'autre part, l'adaptation en diminution et en augmentation d'amplitude. Nos donnees permettent de dissequer les mecanismes d'adaptation saccadique dans leur complexite et de mettre en evidence des structures neuronales indispensables a leur mise en place. Notre travail constitue egalement le support pour le developpement de nouvelles procedures de reeducation, basees sur la plasticite oculomotrice.