Miracle-dz/UniFAR-FTUs huggingface dataset:
Intracellular, environmental and biotic interactions influence recruitment of benthicMicrocystis(Cyanophyceae) in a shallow eutrophic lake

Microcystis is known to overwinter on sediment surfaces and provide an inoculum to support water column blooms in lakes. There is uncertainty as to whether recruitment is an active process triggered by internal changes in buoyancy, or a passive process induced by resuspension. The effect on Microcystis recruitment of ammonium, light and temperature was assessed in laboratory experiments using sediments collected in a small eutrophic lake from two habitats: near-edge (containing Microcystis and Aphanizomenon gracile) and mid-lake (predominantly Microcystis). In all experiments single cells, rather than colonies, accounted for the majority (>55%) of recruited cells. Microcystis recruitment was significantly lower (P < 0.001) in near-shore samples suggesting that A. gracile elicits allelopathic effects on Microcystis. In mid-lake samples, Microcystis recruitment was significantly higher at moderate ammonium concentrations (0.1, 0.2 and 0.5 mg L−1; P < 0.001), at two temperatures (16 and 25°C; P < 0.001) and high light intensities (50 and 100 µmol m−2 s−1; P < 0.01). Microcystis cells were isolated from sediment in spring, early and late summer and assessed using transmission electron microscopy. The percentage of cell area filled with gas vesicles increased significantly (P < 0.001). These data demonstrate that allopathic interactions, ammonium, light and temperature can individually and synergistically regulate gas vesicle synthesis and Microcystis recruitment.
KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma.

PURPOSE In patients with neuroblastoma (NB), treatment with anti-GD2 monoclonal antibody (mAb) directs natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC) against tumor cells. However, tumor cytotoxicity is attenuated by ligation of inhibitory killer immunoglobulin-like receptors (KIRs) by HLA class I molecules. KIR3DL1 polymorphism influences its ability to engage HLA-Bw4 ligands. We tested the hypothesis that poorly interacting combinations of KIR3DL1 and HLA ligands are more permissive of mAb-mediated antitumor effect. METHODS KIR3DL1 and HLA-B subtyping were performed with a multiplex intermediate-resolution polymerase chain reaction assay for a cohort of 245 patients who were treated with antibody 3F8 for high-risk NB. Patient outcomes were analyzed according to expected degree of interaction between KIR3DL1 and HLA-B subtypes and grouped as strong, weak, or noninteractors. A comparison of NK response to 3F8 mAb opsonized NB cells between strong- and noninteracting donors was performed by flow cytometry. RESULTS KIR3DL1 and HLA-B subtype combinations associated with noninteraction as a result of lack of receptor expression [KIR3DL1(-)], failure of interaction with inhibitory ligands [KIR3DS1(+)], or absence of KIR ligands resulted in significantly improved overall and progression-free survival. Patients with KIR3DL1 and HLA-B subtype combinations that were predictive of weak interaction had superior outcomes compared with those that were predictive of strong interaction; however, both groups were inferior to those with noninteracting subtype combinations. In vitro analysis of 3F8-mediated ADCC showed that KIR3DL1(-) and 3DS1(+) NK cells were insensitive to inhibition by HLA-Bw4-expressing NB targets. CONCLUSION We conclude that KIR3LD1 and HLA-B allele combinations can have a prognostic impact on patient survival after treatment with anti-GD2 mAb that relies on NK-ADCC. The survival advantage seen in noninteracting combinations supports the therapeutic disinhibition of individuals with strongly interacting KIR and ligand pairs.
Parenting Styles and Academic Achievement in College Students

The purpose of this study was to investigate the relationship between parenting styles and college academic achievement. An ethnically diverse group of college students reported their GPA and responded to the Parenting Style Index. Parenting style scores were unrelated to college GPA. Additional analyses of ethnic groups indicated differences in maternal involvement and strictness and relationship of these variables to GPA.
Apramycin: minimal inhibitory concentrations for avian Escherichia coli and serum levels after intramuscular injection in turkeys.

The minimal inhibitory concentrations (MIC) of apramycin, a unique aminocyclitol antibiotic, for 100 Escherichia coli isolates recovered from clinical cases of avian colibacillosis were determined using the agar dilution method. All isolates were inhibited at apramycin concentration of 8.0 micrograms/ml; 90 and 50% of the isolates were inhibited at 6.6 and 3.4 micrograms/ml, respectively. A commercial injectable product containing 200 mg apramycin/ml was administered intramuscularly (i.m.) to groups of 6- and 12-week-old turkeys at 10, 15 and 20 mg/kg. Apramycin was quickly absorbed from the i.m. injection site. Mean peak serum drug concentrations were reached 1 h after treatment and were 19.5, 27.5 and 36.0 micrograms/ml, respectively. The serum elimination half-life (t 1/2) of the drug ranged between 1.75 h for the 10 mg/kg dose and 2.5 h for the 20 mg/kg dose. Very low concentrations of the drug were found 24 h after treatment. Duration of serum apramycin concentrations in relation to the MIC, dose, and age of birds was determined.
Eventive existentials in Catalan and the topic-focus articulation

The role of codas in existential sentences has been a matter of debate since the early 70's, but under this label a quite heterogeneous set of material has been included, leading to much misplaced discussion. A case which is so far unresolved is that of eventive existential sentences: Yesterday, there was a live pig roasted. This existential construction asserts the existence of a situation involving the pivot (a live pig) and the coda (roasted) rather than just the existence of the individual denoted by the pivot. In this article I will revisit this construction in light of partially unattested data from Catalan, a Romance language which is well-known for showing a systematic violation of the Definiteness Effect in existentials. I will concentrate on extraction facts and information structure to show that recent proposals favouring a small clause analysis of eventive existentials in Catalan (Leonetti 2008) are weak on syntactic grounds, and inconsistent on semantic and informational grounds. Given this evidence, I will defend a VP-adjunct analysis of codas in eventive existentials, where both the pivot and the coda form part of the assertion, and a null stage topic, optionally restricted by an overt locative, counts as the topic of the sentence
Toxicity of methyl tertiary‐butyl ether (MTBE) following exposure of Wistar Rats for 13 weeks or one year via drinking water

Thirteen‐week and one‐year toxicity studies of methyl tertiary‐butyl ether (MTBE) administered in drinking water to Wistar rats were conducted. Male and female rats were exposed to MTBE in drinking water at 0.5, 3, 7.5 and 15 mg ml−1 for 13 weeks and at 0.5, 3 and 7.5 (males) or 0.5, 3 and 15 mg ml−1 (females) for 1 year. Body weights were reduced only in males following 13 weeks of exposure. Reduced water consumption and urine output were observed in males and females exposed to MTBE. Kidney cell replication and α2u‐globulin levels in males were increased at 1 and 4 weeks of MTBE exposure and tubular cell regeneration was increased in male kidneys exposed to MTBE concentrations of 7.5 mg ml−1 or greater for 13 weeks. Wet weights of male kidneys were increased following 13 weeks, 6 months and 1 year of exposure to MTBE concentrations of 7.5 mg ml−1 or greater. Kidney wet weights were increased in females at MTBE concentrations of 15 mg ml−1 for 13 weeks. Tertiary‐butyl alcohol blood levels increased linearly with dose in males and females following 1 year of exposure. Chronic progressive nephropathy (CPN), of minimal to mild severity, increased in males, but not females, with 1 year of MTBE exposure. In summary, exposure of Wistar rats to MTBE in the drinking water resulted in minimal exposure‐related effects including limited renal changes in male rats suggestive of α2u‐globulin nephropathy following 13 weeks of exposure and an exacerbation of CPN in males at the end of 1 year of exposure. Copyright © 2011 John Wiley & Sons, Ltd.
Luetic lymphadenitis: a clinical and histologic study of 20 cases.

The clinical features and histopathologic changes in 20 cases of luetic lymphadenitis are analyzed. Nine of the 20 patients complained of a mass and pain in the inguinal region. In six patients surgical procedures were performed because the possibility of incarcerated hernia could not be excluded. Malignant disease was considered in the clinical differential diagnoses of four of seven patients who had generalized enlargement of their lymph nodes. Syphilis was diagnosed preoperatively in three cases. The histologic changes of luetic lymphadenitis are variable. Those which occurred most frequently in the inguinal lymph nodes were chronic inflammation and extensive fibrosis of the capsule and pericapsular tissues, numerous plasma cells, vascular changes and follicular hyperplasia. Although this constellation is not pathognomonic of luetic lymphadenitis, the changes are sufficiently distinctive that syphilis should be considered a diagnostic possibility. Spirochetes were identified in the lymph nodes of all patients in the study. In each of two cases a histologic diagnosis of sarcoidosis was considered because the lymph nodes contained noncaseating granulomas. Other tissue reactions in the inguinal lymph nodes included abscesses that contained spirochetes and granulomas associated with giant cells. Follicular hyperplasia was present in lymph nodes from the occipital, cervical, and axillary regions. Spirochetes were sought and identified in these nodes because these patients’ serologic tests for syphilis had been positive. Although spirochetes were found in all portions of the lymph nodes, they were most consistently identified in the walls of blood vessels.
Secondary Acute Lymphoblastic Leukemia after Hodgkin's Lymphoma or a Coincidental Association of Two Hematological Malignancies?

ABSTRACT Secondary acute lymphoblastic leukaemia (sALL), defined as acute lymphoblastic leukaemia following another malignancy, irrespective of previous treatment, is a rare disease, and its biological characteristics have not been accurately described. We report the case of a 24-year old patient followed for Hodgkin's lymphoma at our clinic, who develops and is diagnosed, less than a year after obtaining complete remission, as having pro-B acute lymphoblastic leukaemia This case has been a real diagnostic and treatment challenge, as sALL following another haematological malignancy is quite rare. CONCLUSION It is necessary to better identify the prognostic factors of haematological malignancies in order to prevent the appearance of sALL.
Cerebral and meningeal multiple myeloma after autologous stem cell transplantation. A case report and review of the literature

Meningeal involvement of multiple myeloma is a very rare complication. Defining meningeal myelomatosis (MeM) as the presence of plasma cells in the cerebrospinal fluid in a patient with multiple myeloma, we have found 53 previously reported cases in the literature, where the diagnosis MeM has been made while the patient was alive. Using Kaplan Meier statistics we have found the median survival, from the time of diagnosis of MeM, to be 1.5 months. We report a case with MeM and possible cerebral myeloma shortly after autologous stem cell transplantation, and compare it with earlier published cases. Am. J. Hematol. 62:228–233, 1999. © 1999 Wiley‐Liss, Inc.
Far-Ultraviolet Observations of the Monogem Ring

We present the results of far-ultraviolet (FUV) observations of the Monogem ring made with the FIMS/SPEAR instrument. The global map constructed from the C IV λλ1548, 1550 emission lines presents clear evidence of the interaction of the Monogem ring with the ambient medium. The image shows a half-ring feature in the low-latitude region, with its peak along the distorted boundary of the X-ray ring, where hot gas is in direct contact with the newly found Hα ring (the Gemini Hα ring) centered at (l, b) ~ (191.5°, +5.0°). Only a small portion of the X-ray ring is bright in C IV in the high-latitude region, where hot gas is seen to extend to a great distance from the ring. We have also detected other ionic emission lines in several regions of the Monogem ring, such as C III λ977, O VI λλ1032, 1038, Si II* λ1533, He II λ1640, and O III] λ1666.
Common Mental Disorders and Sickness Absence: A Register-Linkage Follow-Up Study Among Finnish Municipal Employees

Objective: This study examined how common mental disorders (CMD) at different severity levels are associated with short (1 to 3-day), intermediate (4 to 14-day), and long (15+ day) sickness absence (SA) among Finnish municipal employees. Methods: Survey data collected among the 40 to 60-year-old employees of the City of Helsinki in 2000 to 2002 were prospectively linked with employer's SA register data (N = 6554). Associations of CMD (GHQ-12) with SA in a 5-year follow-up were examined with quasi-Poisson regression. Results: Increasing GHQ-12 scores were associated with a higher number of SA spells. The highest GHQ-12 scores were associated with the highest number of short, intermediate, and long SA spells. Adjusting for social and health-related covariates attenuated the associations but they remained. Conclusion: Increasing severity of CMD increased the risk of short, intermediate, and long SA among Finnish employees. CMD should be tackled to prevent SA and promote work-ability among aging employees.
Intestinal parasites infection and associated factors among school children in Dagi primary school, Amhara National Regional State, Ethiopia

Introduction: Intestinal parasitic infections are among the most common communicable diseases worldwide, particularly in developing countries. Worldwide, about 3.5 billion people are affected, and 450 million are ill as a result of these infections, among whom, the majority are children. The objective of this study was to assess prevalence of intestinal parasites infection and associated risk factors among school children in Dagi primary school, ANRS, Ethiopia. Methods: Institutional-based cross-sectional study was conducted by involving 399 school children from 24 September to 19 October, 2012. Structured questionnaires were used to identify environmental, socio-demographic and behavioral factors and stool specimens were collected and examined for parasites using direct smear and formal-ether concentration technique. Data analysis was done by using SPSS version 15 statistical soft ware. Results: Eight species of intestinal parasites were identified with an overall prevalence of 77.9%. Students were infected with one or more intestinal parasites and the predominant parasite was hook worm, 94 (23.6%) followed by G. lamblia 91 (22.8%), E. histoltica 86 (21.6%) and Strongyloides 6 (1.5%). The presence of mixed parasitic infection was 106 (34.1%), double and triple infections were 97 (91.5%) and 9 (8.5%) respectively. Intestinal parasitic infection was higher in children whose fathers’ occupational status were farmers, who had unclean finger nails and who did not have the habit of wearing shoes (p parasites infection was an important public health problem among Dagi primary school children. Therefore, the local health office and other governmental and non-governmental organizations need to give attention to this serious problem of intestinal parasitic infection of school children.
The Role of Sensory Attributes in Marketing Organic Food: Findings from a Qualitative Study of Italian Consumers

This paper uses a qualitative marketing research technique to explore in-depth sensory experiences, expectations, and perceptions of organic consumers when purchasing and eating organic food. Five focus-group interviews supported by semi-structured questionnaire were performed in Italy during 2009. Findings suggest that sensory attributes may be more relevant for older than for younger participants. Consumers largely agree that organic food should differ from conventional items, but variety is also expected among organic products themselves. Appearance and odor appear to be the most important sensory attributes when consumers purchase food, while tase and odor are the most important attributes when eating. Sensory-related information seems to play a crucial role when consumers are choosing which product to buy for the first time.
Episodic mass ejections from common-envelope objects

After the initial fast spiral-in phase experienced by a common-envelope binary, the system mayenter a slow, self-regulated phase, possibly lasting hundreds of years, in which all the energy released by orbital decay can be efficiently transported to the surface, where it is radiated away.If the remaining envelope is to be removed during this phase, this removal must occur throughsome as-yet-undetermined mechanism. We carried out 1D hydrodynamic simulations of alow-mass red giant undergoing a synthetic common-envelope event in such a slow spiral-inphase, using the stellar evolutionary code MESA. We simulated the heating of the envelopedue to frictional dissipation from a binary companion's orbit in multiple configurations and investigated the response of the giant's envelope. We find that our model envelopes become dynamically unstable and develop large-amplitude pulsations, with periods in the range 3-20yr and very short growth time-scales of similar order. The shocks and associated rebounds that emerge as these pulsations grow are in some cases strong enough to dynamically eject shellsof matter of up to 0.1 M⊙, ~10 percent of the mass of the envelope, from the stellar surfaceat above escape velocity. These ejections are seen to repeat within a few decades, leading toa time-averaged mass-loss rate of the order of 10 -3 M⊙ yr -1 , which is sufficiently high torepresent a candidate mechanism for removing the entire envelope over the duration of theslow spiral-in phase.
Assessing drug effects on cerebral autoregulation using the static rate of autoregulation.

We thank Drs. Sosis and Cohen for their interest in our case report (1). The authors point out issues of topical importance concerning both corneal injury and glaucoma cares, providing a contributive specialist opinion. However (and unfortunately), they misunderstood our message. Indeed, as announced in the title part of our manuscript, we report a diagnostic misadventure that could have been highly deleterious for the patient (1). An acute glaucoma following nonocular surgery was not diagnosed. Therefore, the appropriate treatment was delayed (1). Moreover, the patient was not aware that she had chronic angle-closure associated hyperopia (1). Glaucoma and/or corneal injury are routine diagnoses in patients referred to an ophthalmology unit with only an eye complaint (2). Glaucoma is, however—as developed in the discussion part of our text and previously—an uncommon occurrence following nonophthalmologic surgery (1,3). We believe (and previous clinical reports confirm) that such a diagnostic misadventure could have occurred for other colleagues following nonocular surgery (3). As do others, we strongly believe that clinical failures are of pedagogical value and should be published (4). In accordance with this statement, we reported our inappropriate clinical approach with a pedagogical goal. Letters to the Editor, if any, were expected to be on this pedagogical ground, in contrast with the letter from Drs. Sosis and Cohen.
Trajectory planning and control for biped robot with toe and heel joints

In this paper, a trajectory planning and a control for biped robots with toe and heel joints are shown. We added toe and heel joints to a basic biped robot. A trajectory planning is extended for the walking with the toe and heel joints. Using this mechanism and this trajectory planning, the stride can be increased more. Additionally, a control planning is presented for division of walking stabilization and environmental adaptation. A time-based switching impedance controller with the toe and heel joints is proposed for adaptation to uneven terrain. Using this control planning and the proposed method, the stable walking on the rough terrain is realized. The validity is confirmed by experimental results.
Variability of cell proliferation in the proximal and distal colon of normal rats and rats with dimethylhydrazine induced carcinogenesis.

AIM To investigate the patterns of cell proliferation in proximal and distal colons in normal rats and rats with 1,2-dimethylhydrazine (DMH) induced carcinogenesis using the thymidine analogue bromodeoxyuridine. METHODS Colonic crypt cell proliferation was immunohistochemically detected using the anti-bromodeoxyuridine Bu20a monoclonal antibody. RESULTS Marked regional differences were found in both groups. Total labelling index (LI) and proliferative zone size in both normal (8.65+/-0.34 vs 7.2+/-0.45, 27.74+/-1.07 vs 16.75+/-1.45) and DMH groups (13.13+/-0.46 vs 11.55+/-0.45, 39.60+/-1.32 vs 35.52+/-1.58) were significantly higher in distal than in proximal colon (P<0.05), although the number of cells per proximal crypt was greater (31.45+/-0.20 vs 34.45 +/-0.39, 42.68+/-0.53 vs 49.09+/-0.65, P<0.0001). Crypt length, total LI and proliferative zone size all increased in both proximal and distal regions of DMH rats compared to normal controls (P<0.0001). In DMH-treated rat colon a shift of labelled cells to higher crypt cell positions was demonstrated distally whilst a bi-directional shift was evident proximally (P<0.05). CONCLUSION Our results show that changes in cell proliferation patterns, as assessed by bromodeoxyuridine uptake, can act as a reliable intermediate marker of colonic cancer formation. Observed differences between proliferation patterns in distal and proximal colon may be associated with the higher incidence of tumors in the distal colon.
Mate choice is not affected by mating history in the simultaneously hermaphroditic snail Lymnaea stagnalis.

Mate choice based on mating history is one way to optimize the distribution of one’s sperm. This is especially pertinent when donating semen is costly. Owing to sperm competition many species allocate different amounts of sperm depending on their partners’ mating histories. The hermaphroditic Lymnaea stagnalis has a preference for inseminating different partners, rather than the same one twice. Moreover, virgin partners receive more sperm than nonvirgins. Here we aim to determine whether these hermaphrodites prefer to inseminate virgins. Therefore, focal animals were offered a choice between one mating partner raised in isolation and one raised in a group. For each rearing condition we also measured individual growth, onset of egg laying (waiting time) and hatching success. Of the growth parameters we found that only the asymptotic size differed, with the virgins attaining a larger size. This coincides with the delayed onset of laying selfed eggs by virgins. Selfed eggs did not differ in hatching success from outcrossed eggs. The choice experiment revealed that focal individuals mated randomly with animals raised in isolation (virgins) and raised in groups (nonvirgins). This leads us to conclude that the decisions about whether to mate with an encountered individual and how much sperm to donate to this individual are two separate processes.