Miracle-dz/UniFAR-FTUs huggingface dataset:
Objective Measures of Tinnitus: a Systematic Review.

BACKGROUND The purpose of this review is to systematically appraise the English-language literature to identify methods of objectively diagnosing and measuring the severity of subjective idiopathic nonpulsatile tinnitus. MATERIALS AND METHODS A systematic literature search was undertaken from the databases of MEDLINE (1946-May 2018), EMBASE (1980-May 2018), CINAHL (1981-May 2018), and BNI (1992-May 2018) according to predefined inclusion and exclusion criteria. RESULTS We identified 21 articles in this field. Reported objective tests include blood tests, electrophysiology measures, radiological measures, and balance tests. The overall quality of evidence was low, with most studies being low-powered. DISCUSSION Our review has not identified any reliable or reproducible objective measures of tinnitus. However, this piece of work has highlighted emerging areas where further high quality research may lead to the development of an effective method for objectively identifying and measuring the severity of tinnitus.
Parents’ Reports of Preschoolers’ Diets: Relative Validity of a Food Frequency Questionnaire and Dietary Patterns

The accurate assessment of food consumption is crucial in nutritional studies. Since modern nutrition science has become more interested in diet as a whole, studies validating food frequency questionnaires (FFQs) and exploratory dietary patterns are needed. We aimed at examining the relative validity of a 47-item FFQ against three-day food records among three- to six-year-old Finnish children, as well as investigating the consistency of the dietary patterns derived using the principal component analysis (PCA), with food record and FFQ data as inputs. We conducted the PCA without forcing the food record data to match the FFQ items. Altogether, 75% or more of the participants were classified into the same or adjacent quarter of vegetables and fruits as well as sugary food consumption. Furthermore, the intake of folate and vitamin C increased linearly in the quarters of vegetable and fruit consumption, as did the intake of sucrose in quarters of sugary food consumption. Three fairly similar dietary patterns were identified from food records and FFQ data. Concerning the patterns, more than 70% of the participants were classified into the same or adjacent quarter. However, the Spearman correlation coefficients between the respective pattern scores were low (0.25–0.33). The FFQ showed acceptable validity when ranking food group consumption compared to food records. Additionally, the FFQ-derived dietary patterns were consistent with those derived using food record data.
Coach Competences to Induce Positive Affective Reactions in Sport and Exercise—A Qualitative Study

Positive affective reactions are a crucial aspect in physical activity maintenance. Affective reactions to sport and exercise were found to be important factors of physical activity. Coaches could be an important medium to induce positive affective reactions of participants in sport and exercise. Understanding how coaches trigger positive affective reactions (AR) during physical activity is a crucial aspect for increasing maintenance in sport and exercise. The aim of this study is to identify the competences of the coaches which are associated with perceived positive AR of participants during sport and exercise. To identify these factors, semistructured in-depth interviews were conducted with 18 participants, who take part in sport and exercise (nine female and nine male) of heterogeneous age (mean age 42.6; SD = 19.25; under 30 years, 30 to 60 years, 60 years and above) and who have different athletic backgrounds (individual sports, team sports, and gym classes). Four key coach competence factors were identified and used to design an integrated model. Three general competences: context sensitivity, social–emotional competences, professional competences, and the specific competences in the behaviour-related competences.
Modulation of the lipid profile, hepatic and renal antioxidant activities, and markers of hepatic and renal dysfunctions in alloxan-induced diabetic rats by virgin coconut oil.

BACKGROUND Research studies that holistically investigated the effect of administration of virgin coconut oil (VCO) on diabetic humans or animals are limited in literature. OBJECTIVE To investigate the effect of administration of VCO on lipid profile, markers of hepatic and renal dysfunction, and hepatic and renal antioxidant activities of alloxan induced diabetic rats. METHODS Twenty-four male albino rats were used, and they were divided into four groups of six rats each. Group 1 (Normal Control, NC) received distilled water (1 mL/kg); Group 2 (VCO Control) received VCO (5 mL/kg); Group 3 (Diabetic Control, DC) received distilled water (1 mL/kg); Group 4 (Test Group, TG) received 5 ml/kg of VCO. RESULTS There were no significant differences in blood glucose, body weights, relative liver weights, relative kidney weights, hepatic and renal superoxide dismutase (SOD) activities, malondialdehyde (MDA) , albumin, aspartate amino transaminase (AST), alanine amino transaminase (ALT), alkaline phosphatase (ALP) , urea, creatinine, uric acid, total cholesterol, triacylglycerol, very low density lipoprotein cholesterol (VLDL) and low density lipoprotein cholesterol (LDL) concentrations; significant increases of renal glutathione (GSH), hepatic catalase, glutathione peroxidase (GPx) and GSH but significant reduction of renal GPx and catalase activities of VCO control group compared with NC group. There were significant increases in blood glucose, relative liver and kidney weights, hepatic GPx, hepatic and renal MDA concentration, ALP, AST, ALT, urea, creatinine, uric acid, triacylglycerol, total cholesterol, LDL and VLDL concentrations; significant decreases in body weight, hepatic SOD and GSH activities and albumin concentration but no significant differencein hepatic catalase activity of DC group compared with NC group. Administration of VCO to diabetic rats positively modulated these parameters compared with the diabetic control. CONCLUSION The study showed the potentials of VCO in the management of hyperlipidemia, renal and hepatic dysfunctions imposed by hyperglycemia and by oxidative stress in diabetic rats.
Enantiomeric Variability of Distaminolyne A. Refinement of ECD and NMR Methods for Determining Optical Purity of 1-Amino-2-Alkanols

Sample configurations of distaminolyne A (1a); isolated from the ascidians Pseudodistoma opacum and P. cereum, and collected at different sites in New Zealand, were investigated by two methods: Exciton coupled electronic circular dichroism (EC ECD) of the corresponding N,O-dibenzoyl derivative 1b; and chiral reagent derivatization of 1a with (S)- and (R)-α-methoxyphenylacetic acid (MPA), followed by ¹H-NMR analysis. Configuration and optical purity of 1a (%ee) was found to vary depending on the geographic distribution of ascidian colonies. An improved method for preparing N,O-diarenoyl derivatives of 1a was optimized. The EC ECD method was found to be complementary to the MPA-NMR method at different ranges of %ee.
Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

The lipid distribution of plasma membranes of eukaryotic cells is asymmetric and phospholipid scramblases disrupt this asymmetry by mediating the rapid, nonselective transport of lipids down their concentration gradients. As a result, phosphatidylserine is exposed to the outer leaflet of membrane, an important step in extracellular signaling networks controlling processes such as apoptosis, blood coagulation, membrane fusion and repair. Several TMEM16 family members have been identified as Ca2+-activated scramblases, but the mechanisms underlying their Ca2+-dependent gating and their effects on the surrounding lipid bilayer remain poorly understood. Here, we describe three high-resolution cryo-electron microscopy structures of a fungal scramblase from Aspergillus fumigatus, afTMEM16, reconstituted in lipid nanodiscs. These structures reveal that Ca2+-dependent activation of the scramblase entails global rearrangement of the transmembrane and cytosolic domains. These structures, together with functional experiments, suggest that activation of the protein thins the membrane near the transport pathway to facilitate rapid transbilayer lipid movement.
The Photographs of Meaning Program for Pediatric Palliative Caregivers: Feasibility of a Novel Meaning-Making Intervention

Background: Research indicates that informal caregiving can have intense physical and mental impact on the individual. Relative to caregivers of adults, pediatric palliative caregivers appear less in literature despite experiencing greater mental, physical, financial, and social strain. There is limited research on the creation and evaluation of interventions specifically for this population despite clear need. Objective: This study aims to evaluate the feasibility and engagement of the Photographs of Meaning Program, a modified meaning-making intervention for pediatric palliative caregivers. Design: Participants completed a pre–post intervention meaning-in-life measure. Over a 9-week period, participants followed a meaning-making curriculum whereby they created and shared photo narratives via social media. As part of the intervention, a community photo exhibition was held featuring these photo narratives. Exit interviews were also conducted at study close. Setting/Participants: Nine individuals providing informal care to children in a pediatric palliative care program participated in the intervention. All participants were female and are older than 18 years. Settings for research include participant homes and at The Center for Hospice and Palliative Care in Cheektowaga, New York. Results: Participants posted 95 photographs and 96 narratives during the intervention, posting on average once each week. Statistical analysis within the small sample indicated an increased presence of meaning in the lives of participants (P = .022). Exit interviews conveyed satisfaction with the intervention. Conclusions: Findings suggest that the Photographs of Meaning Program is a practical intervention with life-enhancing potential for pediatric palliative. Future research should aim to collect additional evidence of the intervention’s effectiveness.
Effect of preoperative smoking cessation on postoperative pain outcomes in elderly patients with high nicotine dependence

Objective: To investigate the effect of smoking cessation before surgery on postoperative pain and analgesic consumption after thoracoscopic radical resection of lung cancer in elderly patients with high nicotine dependence. Methods: A total of 107 male patients, ages 60 to 70 years, undergoing elective thoracoscopic radical lung cancer surgery from July 2017 to July 2018 were enrolled into 3 groups: group A (highly nicotine-dependent and discontinued smoking <3 weeks before surgery, n = 36), group B (highly nicotine-dependent and discontinued smoking >3 weeks before surgery, n = 38), and group C (nonsmokers, n = 33). Postoperative sufentanil consumption, visual analog scale (VAS) pain scores at rest and during cough, rescue analgesia, opioid-related adverse events, and patient satisfaction were assessed from 0 to 48 h postoperatively. Results: Patient characteristics were comparable among the 3 groups. Sufentanil consumption and VAS pain scores from postoperative 0 to 48 h were significantly higher in groups A and B than in group C. In addition, group B had lower sufentanil consumption and pain scores than group A. No differences in the need for rescue analgesia, patient satisfaction, or occurrence of postoperative adverse events, including nausea, vomiting, respiratory depression, and oversedation, were observed among the 3 groups. Conclusion: Compared with nonsmokers, highly nicotine-dependent male patients who were deprived of cigarettes experienced more severe pain and required treatment with more sufentanil after thoracoscopic radical lung cancer surgery. Moreover, preoperative smoking cessation at least 3 weeks before surgery led to better postoperative pain outcomes than smoking cessation within 3 weeks of surgery.
Can adaptive post-processing of storage phosphor plate panoramic radiographs provide better image quality? A comparison of anatomical image quality of panoramic radiographs before and after adaptive processing

Abstract Objective: The objective of the present study was to study the effect of adaptive image processing on the visibility of anatomical structures in storage phosphor plate (SPP) panoramic images. Materials and methods: Three hundred SPP panoramic X-ray radiographs of children and adolescents were used. The radiographs were post-processed using general operator processor (GOP) technology, resulting in both a standard-processed and a GOP-processed radiograph. Four specialists in dental radiology compared the structural image quality of all standard-processed and GOP-processed panorama images for six anatomical structures, using a six-point scale for visual grading characteristics (VGC) analysis. Results: For three of the anatomic structures – the root canal space of the mandibular left first premolar, mandibular canal left side and periodontal ligament space of the mandibular right first molar – there was a statistically significant difference to the GOP’s advantage. For the three remaining structures – dentino-enamel junction of the maxillary right first molar, crista alveolaris of the mandibular left molar area and floor of maxillary sinus right side – no significant difference between standard processing and GOP processing was obtained. Conclusions: The study demonstrates that it is possible to improve the quality of SPP radiographs and the visibility of anatomical structures by using the GOP technique. Manufacturers’ image-processing programs can be further developed, as there is a possibility of improving the diagnostic content of an image with external processing.
Heat Treatment of AZ91 Magnesium Alloy Coated with an Al2O3 Thin Film with Fluidized Bed Technology

Fluidized bed technology is a methodology widely known in the manufacturing environment for surface treatment of metals. Within the field of surface coating, it has already been exploited for the coating of a magnesium alloy creating a compact layer of Al2O3. The result was an improvement in mechanical and tribological properties, along with improved corrosion resistance. In this context, the work proposed is addressed towards the evaluation of the effects of thermal post-treatment on the alumina coating produced by means of the fluidized-bed technology. To analyse the effects of heat treatments the morphology, composition and hardness of the samples were investigated along with adhesion and wear resistance of the alumina film. The results obtained show how the temperature affects the surface morphology and promotes the diffusion of magnesium towards the alumina superficial layer. The mechanisms triggered by heat treatments increase the adhesion of the surface film obtained in the deposition process, improving its mechanical and tribological properties.
Moderate exercise in mice improves cancer plus chemotherapy‐induced muscle wasting and mitochondrial alterations

Cancer cachexia is a multifactorial syndrome characterized by anorexia, body wasting, and muscle and adipose tissue loss, impairing patient's tolerance to anticancer treatments and survival. The aim of the present study was to compare the effects induced in mice by tumor growth alone (C26) or in combination with chemotherapy [C26 oxaliplatin and 5‐fluorouracil (oxfu)] and to evaluate the potential of moderate exercise. Oxfu administration to C26 mice exacerbated muscle wasting and triggered autophagy or mitophagy, decreased protein synthesis, and induced mitochondrial alterations. Exercise in C26 oxfu mice counteracted the loss of muscle mass and strength, partially rescuing autophagy and mitochondrial function. Nevertheless, exercise worsened survival in C26 oxfu mice in late stages of cachexia. In summary, chemotherapy further impinges on cancer‐induced alterations, worsening muscle wasting. An ideal multifactorial and early intervention to prevent cancer cachexia could take advantage of exercise, improving patient's energy metabolism, mobility, and quality of life. —Ballarò, R. , Beltrà, M. , De Lucia, S. , Pin, F. , Ranjbar, K. , Hulmi, J. J., Costelli, P., Penna, F. Moderate exercise in mice improves cancer plus chemotherapy‐induced muscle wasting and mitochondrial alterations. FASEB J. 33, 5482–5494 (2019). www.fasebj. org
The Incidence of Graves’ Hyperthyroidism Increases in Early Pregnancy and the Late Postpartum Period

Background Hyperthyroidism in women of reproductive age is predominantly caused by Graves’ disease. Pregnancy-associated changes in the immune system may influence the onset of disease, but population-based incidence rates in and around pregnancy have not been reported. The objective of these authors was to estimate the incidence of maternal hyperthyroidism (defined by prescriptions for antithyroid drugs being filled) in and around pregnancy and to compare this with the incidence of other autoimmune diseases, such as rheumatoid arthritis (RA) and inflammatory bowel disease (IBD).
The use of ultrasound‐indicated cerclage or cervical pessary in asymptomatic twin pregnancies with a short cervix at midgestation

Spontaneous preterm birth in women with a twin pregnancy is one of the main causes of perinatal mortality and morbidity. Our aim was to review the perinatal outcome of asymptomatic twin pregnancies with a sonographic short cervical length during the second trimester treated with an ultrasound‐indicated cerclage or cervical pessary.
Relationship between body mass index and outcomes in patients with atrial fibrillation treated with edoxaban or warfarin in the ENGAGE AF-TIMI 48 trial.

AIMS To investigate the relationship between body mass index (BMI) and outcomes in patients with atrial fibrillation (AF). METHODS AND RESULTS In the ENGAGE AF-TIMI 48 trial, patients with AF were randomized to warfarin (international normalized ratio 2.0-3.0) or edoxaban. The cohort (N = 21 028) included patients across BMI categories (kg/m2): underweight (<18.5) in 0.8%, normal (18.5 to <25) in 21.4%, overweight (25 to <30) in 37.6%, moderately obese (30 to <35) in 24.8%, severely obese (35 to <40) in 10.0%, and very severely obese (≥40) in 5.5%. In an adjusted analysis, higher BMI (continuous, per 5 kg/m2 increase) was significantly and independently associated with lower risks of stroke/systemic embolic event (SEE) [hazard ratio (HR) 0.88, P = 0.0001], ischaemic stroke/SEE (HR 0.87, P < 0.0001), and death (HR 0.91, P < 0.0001), but with increased risks of major (HR 1.06, P = 0.025) and major or clinically relevant non-major bleeding (HR 1.05, P = 0.0007). There was a significant interaction between sex and increasing BMI category, with lower risk of ischaemic stroke/SEE in males and increased risk of bleeding in women. Trough edoxaban concentration and anti-Factor Xa activity were similar across BMI groups >18.5 kg/m2, while time in therapeutic range for warfarin improved significantly as BMI increased (P < 0.0001). The effects of edoxaban vs. warfarin on stroke/SEE, major bleeding, and net clinical outcome were similar across BMI groups. CONCLUSION An increased BMI was independently associated with a lower risk of stroke/SEE, better survival, but increased risk of bleeding. The efficacy and safety profiles of edoxaban were similar across BMI categories ranging from 18.5 to >40.
Computational modeling of brainstem circuits controlling locomotor frequency and gait

A series of recent studies identified key structures in the mesencephalic locomotor region and the caudal brainstem of mice involved in the initiation and control of slow (exploratory) and fast (escape-type) locomotion and gait. However, the interactions of these brainstem centers with each other and with the spinal locomotor circuits are poorly understood. Previously we suggested that commissural and long propriospinal interneurons are the main targets for brainstem inputs adjusting gait (Danner et al., 2017). Here, by extending our previous model, we propose a connectome of the brainstem-spinal circuitry and suggest a mechanistic explanation of the operation of brainstem structures and their roles in controlling speed and gait. We suggest that brainstem control of locomotion is mediated by two pathways, one controlling locomotor speed via connections to rhythm generating circuits in the spinal cord and the other providing gait control by targeting commissural and long propriospinal interneurons.
Variation in the Promoter Region of the MC4R Gene Elucidates the Association of Body Measurement Traits in Hu Sheep

The melanocortin 4 receptor (MC4R) gene is expressed in the appetite-regulating areas of the brain and is engaged in the leptin signaling pathway. Although previous studies have identified variants in the coding region of the sheep MC4R gene showing significant associations with birth weight, weaning weight, and backfat thickness, no such associations have been reported for the promoter region. Besides, the essential promoter region of the sheep MC4R has not been delineated. In this study, to better understand the transcriptional regulation of MC4R and to elucidate the association between regulatory variants and haplotypes with body measurement traits in sheep, we cloned and characterized the MC4R promoter. We found that the minimal promoter of the gene is located within the region −1207/−880 bp upstream of the first exon. Real-time quantitative PCR (RT-qPCR) data revealed the mRNA expression of the MC4R gene had a significant difference between sex and age. In the association analysis, eight single nucleotide polymorphisms (SNPs) had a significant association with one or more traits (p < 0.05); of these, two SNPs were novel. Notably, individuals with haplotype H1H2 (CT-GA-GT-GA-GT-GA-GA-CG) were heavier in body weight than other haplotypes. Altogether, variations in the MC4R gene promoter, most notably haplotype H1H2, may greatly benefit marker-assisted selection in sheep.
Responses of growing rabbits to supplementing diet with a mixture of black and red pepper oils as a natural growth promoter

The current study was explored to examine the impacts of dietary inclusion of mixture of black (BPO) and red pepper (RPO) oils as growth promoters on growth, carcass, blood haematology, serum chemistry, immunity and antioxidative status of New Zealand White rabbits (NZW). A number total of 100 5-week-old NZW growing weaned rabbits were randomly allocated into four treatment groups in a complete randomized experiment. The dietary treatment groups were as follows: control: basal diet; BRP0.5: basal diet + 0.25 g BPO + 0.25 g RPO/kg diet; BRP1.0: basal diet + 0.50 g BPO + 0.50 g RPO/kg diet; and BRP1.5: basal diet + 0.75 g BPO + 0.75 g RPO/kg diet. Rabbits fed the highest level of BRP mixture were the heaviest, while the control rabbits were the lightest. During 5-9 weeks of age, a gradual improvement in feed conversion ratio (FCR) was noticed with increasing BRP level. The control group excelled all BRP groups regarding the majority of blood haematological parameters. Liver function was better in rabbits fed BRP enriched diets than the control. A gradual depression (p < 0.05 or 0.01) in serum lipids regardless high-density lipoprotein (HDL) were recorded with elevating BRP level in the diet. The supplementation of BRP mixture enhanced the immune function and serum superoxide dismutase (SOD) activities and depressed serum malondialdehyde (MDA) in comparison with control. It could be concluded that dietary BRP mixture can affect some of growth traits, improve the immunity and antioxidant parameters, lower lipid profile and lipid peroxidation. Based on the study results, the recommended level of BRP mixture is 1.5 g/kg diet.