Miracle-dz/UniFAR-FTUs huggingface dataset:
Parental Bonding and Social Adjustment: Evidence from the Mediation by Emotional Intelligence ======================================================================

The purpose of the present study was to investigate the mediating role of emotional intelligence between the relationship of parental bonding and social adjustment among students. Data were collected on three instruments; Trait Emotional Intelligence Questionnaire (Petrides & Furnham, 2006), Social Adjustment Scale (Weissman & Bothwell, 1976), and Parental Bonding Instrument (Parker, Tupling, & Brown, 1979) from 376 university students selected through simple random sampling. Employing correlation, regression analyses, and sobel tests, the findings showed the significant relationship of parental bonding with social adjustment and emotional intelligence among students; the findings also indicated the significant association of emotional intelligence with social adjustment. Mediation analyses from sobel tests demonstrated that emotional intelligence played a mediating role between the relationships of parental bonding with social adjustment among students. These findings are useful for parents, teachers, and students in the ways that student’s emotional intelligence can help the students to get socially adjusted in the environment.
Acute exposure to foot orthoses affects joint stiffness characteristics in recreational male runners

Commercially available foot orthoses are advocated for the treatment of chronic running injuries, such as patellofemoral pain, yet the mechanisms behind their effects are not well understood. This study aimed to examine the limb and joint stiffness characteristics when running with and without orthotics. Twelve recreational runners ran at 4.0 m/s. Limb stiffness was obtained using a spring-mass model of running by dividing the peak vertical ground reaction force (GRF) by the amount of limb compression. Knee and ankle joint stiffness’s were calculated by dividing the peak sagittal plane joint moment by the joint angular excursion. Differences between orthotic and non-orthotic running conditions were contrasted using paired samples t-tests. The results indicate that both peak knee extensor moment (orthotic = 2.74±0.57 and no-orthotic = 3.12±0.62 Nm/kg) and knee stiffness (orthotic = 5.56±1.08 and no-orthotic = 6.47±1.40 Nm/kg rad) were significantly larger when running without orthotics. This study may give.
Alerting, Orienting, and Executive Control: The Effect of Bilingualism and Age on the Subcomponents of Attention

Life-long experience of using two or more languages has been shown to enhance cognitive control abilities in young and elderly bilinguals in comparison to their monolingual peers. This advantage has been found to be larger in older adults in comparison to younger adults, suggesting that bilingualism provides advantages in cognitive control abilities. However, studies showing this effect have used a variety of tasks (Simon Task, Stroop task, Flanker Task), each measuring different subcomponents of attention and raising mixed results. At the same time, attention is not a unitary function but comprises of subcomponents which can be distinctively addressed within the Attention Network Test (ANT) (1, 2). The purpose of this work was to examine the neurofunctional correlates of the subcomponents of attention in healthy young and elderly bilinguals taking into account the L2 age of acquisition, language usage, and proficiency. Participants performed an fMRI version of the ANT task, and speed, accuracy, and BOLD data were collected. As expected, results show slower overall response times with increasing age. The ability to take advantage of the warning cues also decreased with age, resulting in reduced alerting and orienting abilities in older adults. fMRI results showed an increase in neurofunctional activity in the frontal and parietal areas in elderly bilinguals when compared to young bilinguals. Furthermore, higher L2 proficiency correlated negatively with activation in frontal area, and that faster RTs correlated negatively with activation in frontal and parietal areas. Such a correlation, especially with L2 proficiency was not present in young bilinguals and provides evidence for a bilingual advantage in the alerting subcomponent of attention that characterizes elderly bilinguals' performance. This study thus provides extra details about the bilingual advantage in the subcomponent of attention, in older bilinguals. Consequently, speaking more than one language impacts cognition and the brain later in life.
A Hybrid Feature Selection Method for Software Fault Prediction

SUMMARY Fault prediction aims to identify whether a software module is defect-prone or not according to metrics that are mined from software projects. These metric values, also known as features, may involve irrelevance and redundancy, which hurt the performance of fault prediction models. In order to ﬁlter out irrelevant and redundant features, a Hybrid Feature Selection (abbreviated as HFS) method for software fault prediction is proposed. The proposed HFS method consists of two major stages. First, HFS groups features with hierarchical agglomerative clustering; second, HFS selects the most valuable features from each cluster to remove irrelevant and redundant ones based on two wrapper based strategies. The empirical evaluation was conducted on 11 widely-studied NASA projects, using three di ﬀ erent classiﬁers with four performance metrics (precision, recall, F-measure, and AUC). Comparison with six ﬁlter-based feature selection methods demonstrates that HFS achieves higher average F-measure and AUC values. Compared with two classic wrapper feature selection methods, HFS can obtain a competitive prediction performance in terms of average AUC while signiﬁcantly reducing the computation cost of the wrapper process.
8.0.2 Previous Reviews on Environmental Tobacco Smoke and Coronary Heart Disease in Nonsmokers

In this chapter, epidemiologic studies and other human data regarding the relationship between coronary heart disease (CHD) and exposure to environmental tobacco smoke (ETS) by nonsmokers are reviewed and the overall weight of evidence for an association is presented. In addition to the human evidence, there is confirmatory animal evidence (e.g., Glantz and Parmley, 1991 and 1995), which is summarized briefly.
Sublethal effects of spirodiclofen on the demographic parameters of Tetranychus urticae Koch (Acari: Tetranychidae)

Abstract The two-spotted spider mite, Tetranychus urticae Koch is one of the most common pests of agricultural crops. The use of sublethal doses can reduce the need of pesticides and prevent pests’ resistance, which is an important step in integrated pest management and safely controlling this pest. The sublethal effects (LC5, LC15 and LC35) of spirodiclofen on demographic parameters of T. urticae based on the age-stage, two-sex life table theory were investigated under laboratory conditions [25 ± 2 °C, 60 ± 5% RH and 16:8 (L:D) h]. The longevity, total life span, oviposition period and total fecundity reduced after exposure to LC15 and LC35. Oviposition period ranged from 5.64 to 10.92 days. The gross reproduction rate (GRR), net reproductive rate (R0) and the finite rate of increase (λ) of the mites treated with LC15 and LC35 were inferior to the results when treated with LC5, and control. The values of intrinsic rate of increase (r) was 0.2209 day−1 in the control and this was reduced to 0.1714 day−1 in LC35. Based on these results, considering the negative impact of spirodiclofen on the population growth of T. urticae, this acaricide can be helpful to achieve an efficient control for T. urticae in frame of integrated pest management.
Misdiagnosis of paroxysmal non-epileptic disorders in children

Abstract Paroxysmal non-epileptic disorders (PNEDs) are often misdiagnosed as epilepsy. This study describes cases of misdiagnosed PNEDs. In addition, it identifies aspects of the clinical assessment that may assist in reaching a correct diagnosis. A total of 100 patients (58 boys and 42 girls) were included. Misdiagnosed PNEDs included: breath-holding spells (37%); excessive jitteriness and/or atypical hyperekplexia (15%); vasovagal attack (12%); psychogenic seizures (11%); gastroesophageal reflux (10%); hyperekplexia (5%); masturbation (3%); head nodding (2%); tic (2%); paroxysmal torticollis (1%); migraine (1%); vitamin B12 deficiency-induced tremor (1%). Forty-four (44%) patients were misdiagnosed with epilepsy and parents presented for a second opinion, while 56 (56%) patients were referred with a suspicion of epilepsy. Forty-two (42%) patients received antiepileptic treatment before presenting to us. History emerged as the most helpful diagnostic tool. Examination was only useful in hyperekplexia, while mobile phone video camera emerged as a potentially useful but underutilized diagnostic tool and were present in 85% of the patients. PNEDs are often misdiagnosed as epilepsy. Elements that were helpful in making a correct diagnosis included history, examination, and witnessing the attack in clinic or on mobile phones.
When Strengthening Environmental Regulation Reduces Green Innovation: Theory and Evidence from the Auto Industry

It is commonly believed that strengthening environmental standards increases green innovation. We develop a model and produce empirical evidence which partly disconfirm this view. The model predicts that regulatory change has opposite impacts on innovation when the country is a regulatory leader or a country adopting a standard previously introduced elsewhere. The analysis of panel data from the auto industry from 1992 to 2007 confirms these predictions. We find that regulatory leadership increases innovation whereas innovation falls when the country is a regulatory follower. JEL classification: O31, Q55, Q58
Stochastic Choice and Noisy Beliefs in Games: an Experiment

Much is known about the empirical content of quantal response equilibrium (QRE) which relaxes the rationality requirement of Nash equilibrium by allowing for “noise in actions” while maintaining that beliefs are correct. By contrast, little is understood of the testable restrictions of equilibrium models which allow for “noise in beliefs” while maintaining best response. We introduce noisy belief equilibrium (NBE) for normal form games in which axioms restrict belief distributions to be unbiased with respect to and responsive to changes in the opponents’ behavior. The axioms impose testable restrictions both within and across games, and we compare these restrictions to those of regular QRE (Goeree et al. 2005 ) in which axioms are placed on the quantal response function as the primitive. We show that NBE generates similar predictions as QRE such as the “own payoff effect”, and yet is more consistent with the empirically documented effects of changes in payoff magnitude. Unlike QRE, NBE is a refinement of rationalizability and invariant to affine transformations of payoffs.
Anterior quadratus lumborum block analgesia for total hip arthroplasty: a randomized, controlled study

Background and objectives Quadratus lumborum (QL) block is a new regional analgesic technique for upper and lower abdominal surgeries as part of a multimodal analgesic regime. It has also been reported to relieve pain after total hip arthroplasty (THA). In this prospective, randomized, double-blind study, we compared QL block with control (no block) in patients undergoing primary THA. Methods Eighty patients undergoing primary THA surgery under spinal anesthesia were randomized into two groups, one with and one without QL block. The patients in both groups were randomized after sedation, positioning and ultrasound scanning. Both the patient and the researcher collecting data were blinded to the patient’s group assignment. Opioid consumption and visual analog scores (VAS) pain scores were measured at 12, 24, and 48 hours after surgery. Also, the ambulation distance, patient satisfaction, and length of stay were recorded. Results The study analysis included 36 patients in the QL group and 35 patients in the control group. Both VAS pain score at 24 hours (difference −1.76, 95% CI −2.87 to −0.64) and cumulative opioid consumption were significantly lower in the QL group at 12, 12–24, 24, 24–48, and 48 hours after surgery as compared with the control group (difference at 48 hours −36.13, 95% CI −62.89 to −9.37) (p<0.05). However, there was no difference in pain score at 12 and 48 hours, nor in the ambulation distance and duration of hospital stay between the two groups. The patient satisfaction score was significantly higher in the QL group. Conclusions Our preliminary data show that the QL block provided effective analgesia and decreased opioid requirements up to 48 hours after primary THA. Trial registration number NCT03408483
Interleukin-6 Induces Myogenic Differentiation via JAK2-STAT3 Signaling in Mouse C2C12 Myoblast Cell Line and Primary Human Myoblasts

Postnatal muscle growth and exercise- or injury-induced regeneration are facilitated by myoblasts. Myoblasts respond to a variety of proteins such as cytokines that activate various signaling cascades. Cytokines belonging to the interleukin 6 superfamily (IL-6) influence myoblasts’ proliferation but their effect on differentiation is still being researched. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is one of the key signaling pathways identified to be activated by IL-6. The aim of this study was to investigate myoblast fate as well as activation of JAK-STAT pathway at different physiologically relevant IL-6 concentrations (10 pg/mL; 100 pg/mL; 10 ng/mL) in the C2C12 mouse myoblast cell line and primary human myoblasts, isolated from eight young healthy male volunteers. Myoblasts’ cell cycle progression, proliferation and differentiation in vitro were assessed. Low IL-6 concentrations facilitated cell cycle transition from the quiescence/Gap1 (G0/G1) to the synthesis (S-) phases. Low and medium IL-6 concentrations decreased the expression of myoblast determination protein 1 (MyoD) and myogenin and increased proliferating cell nuclear antigen (PCNA) expression. In contrast, high IL-6 concentration shifted a larger proportion of cells to the pro-differentiation G0/G1 phase of the cell cycle, substantiated by significant increases of both MyoD and myogenin expression and decreased PCNA expression. Low IL-6 concentration was responsible for prolonged JAK1 activation and increased suppressor of cytokine signaling 1 (SOCS1) protein expression. JAK-STAT inhibition abrogated IL-6-mediated C2C12 cell proliferation. In contrast, high IL-6 initially increased JAK1 activation but resulted in prolonged JAK2 activation and elevated SOCS3 protein expression. High IL-6 concentration decreased interleukin-6 receptor (IL-6R) expression 24 h after treatment whilst low IL-6 concentration increased IL-6 receptor (IL-6R) expression at the same time point. In conclusion, this study demonstrated that IL-6 has concentration- and time-dependent effects on both C2C12 mouse myoblasts and primary human myoblasts. Low IL-6 concentration induces proliferation whilst high IL-6 concentration induces differentiation. These effects are mediated by specific components of the JAK/STAT/SOCS pathway.
Prevention of HIV Transmission and the HPTN 052 Study.

The HIV Prevention Trials Network 052 study (HPTN 052) was a clinical trial designed to determine whether early treatment for HIV infection prevented transmission of the virus in couples where one partner was infected with HIV and the other was not, referred to as HIV serodiscordant or serodifferent couples. The study enrolled 1,763 couples at 13 sites in 9 countries in Asia, Africa, and the Americas. HPTN 052 demonstrated a minimum of 96% reduction of HIV in heterosexual couples ascribed to antiretroviral treatment; early treatment of HIV significantly reduced other infections in the HIV-infected subjects. This study, in conjunction with similar research, led to significant changes in international HIV treatment guidelines and the concept of treatment as prevention (TasP). This article provides the scientific background and history of how HPTN 052 came into being, the challenges it faced, and the ultimate impact it had on the fields of HIV treatment and prevention. Expected final online publication date for the Annual Review of Medicine, Volume 71 is January 27, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Anticholinergic Burden, Sleep Quality and Health Outcomes in Malaysian Aged Care Home Residents

The use of anticholinergic medications by residents in aged care homes is associated with increased risk of adverse effects. These include cognitive impairment, sleep disturbances, and falls, and necessitate increased healthcare visits and the associated burden on healthcare systems. The objective of this study was to investigate associations between anticholinergic burden and health outcomes such as independence in activities for daily living, frailty, quality of life, and sleep quality. The study was conducted among residents in Malaysian aged care homes, aged 60 years and above. Anticholinergic burden was calculated using the Anticholinergic Cognitive Burden (ACB) scale. Health outcome measures included independence, assessed using the Katz Activities for Daily Living scale (Katz ADL); quality of life, assessed using the Older People’s Quality of Life Questionnaire (OPQOL); frailty, assessed using the Groningen Frailty Index (GFI); and sleep quality, measured using the Pittsburg Sleep Quality Index (PSQI). Just over one-third (36%) of the study population was exposed to at least one medication with anticholinergic effect. An increased anticholinergic cognitive burden was associated with frailty (p = 0.031), sleep latency (p = 0.007), and sleep disturbances (p = 0.015). Further studies are required to assess the effect of prolonged exposure to anticholinergic medications on health outcomes.
Characterization and Transcriptional Regulation of n-Alkane Hydroxylase Gene Cluster of Rhodococcus jostii RHA1

Gram-positive actinomycete Rhodococcus jostii RHA1 is able to grow on C10 to C19 n-alkanes as a sole source of carbon and energy. To clarify, the n-alkane utilization pathway—a cluster of 5 genes (alkBrubA1A2BalkU) which appeared to be involved in n-alkane degradation—was identified and the transcriptional regulation of these genes was characterized. Reverse transcription-PCR analyses revealed that these genes constituted an operon and were transcribed in the presence of n-alkane. Inactivation of alkB led to the absence of the ability to utilize n-undecane. The alkB mutation resulted in reduction of growth rates on C10 and C12 n-alkanes; however, growths on C13 to C19 n-alkanes were not affected by this mutation. These results suggested that alkB was essential for the utilization of C10 to C12 n-alkanes. Inactivation of alkU showed the constitutive expression of alkB. Purified AlkU is able to bind to the putative promoter region of alkB, suggesting that AlkU played a role in repression of the transcription of alk operon. The results of this study indicated that alkB was involved in the medium-chain n-alkanes degradation of strain RHA1 and the transcription of alk operon was negatively regulated by alkU-encoded regulator. This report is important to understand the n-alkane degradation pathway of R. jostii, including the transcriptional regulation of alk gene cluster.
Identification of 15 T Cell Restricted Genes Evaluates T Cell Infiltration of Human Healthy Tissues and Cancers and Shows Prognostic and Predictive Potential

T cell gene signatures are used to evaluate T cell infiltration of non-lymphoid tissues and cancers in both experimental and clinical settings. However, some genes included in the available T cell signatures are not T cell-restricted. Herein, we propose a new human T cell signature that has been developed via a six-step procedure and comprises 15 T cell restricted genes. We demonstrate the new T cell signature, named signature-H, that differs from other gene signatures since it shows higher sensitivity and better predictivity in the evaluation of T cell infiltration in healthy tissues as well as 32 cancers. Further, results from signature-H are highly concordant with the immunohistochemistry methods currently used for assessing the prognosis of neuroblastoma, as demonstrated by the Kaplan–Meier curves of patients ranked by tumor T cell infiltration. Moreover, T cell infiltration levels calculated using signature-H correlate with the risk groups determined by the staging of the neuroblastoma. Finally, multiparametric analysis of tumor-infiltrating T cells based on signature-H let us favorably predict the response of melanoma to the anti-PD-1 antibody nivolumab. These findings suggest that signature-H evaluates T cell infiltration levels of tissues and may be used as a prognostic tool in the precision medicine perspective after appropriate clinical validation.
High Expression of TTYH3 Is Related to Poor Clinical Outcomes in Human Gastric Cancer

Ion channels play important roles in regulating various cellular processes and malignant transformation. Expressions of some chloride channels have been suggested to be associated with patient survival in gastric cancer (GC). However, little is known about the expression and function of TTYH3, a gene encoding a chloride ion channel, in cancer progression. Here, we comprehensively analyzed the expression of TTYH3 and its clinical outcome in GC using publicly available cancer gene expression and patient survival data through various databases. We examined the differences of TTYH3 expression between cancers and their normal tissues using the Oncomine, UALCAN, and GEO (Gene Expression Omnibus) databases. TTYH3 expression was investigated from immunohistochemistry images using the Human Protein Atlas database. Copy number alterations and mutations of TTYH3 were analyzed using cBioPortal. The co-expression profile of TTYH3 in GC was revealed using Oncomine. The gene ontology and pathway analyses were done using those co-expressed genes via the Enrichr tool to explore the predicted signaling pathways in GC. TTYH3 mRNA and protein levels in GC were significantly greater than those in normal tissue. Kaplan–Meier analysis revealed the upregulation of TTYH3 expression, which was significantly correlated with worse patient survival. Collectively, our data suggest that TTYH3 might be a potential prognostic marker for GC patients.
Intracellular Redox-Balance Involvement in Temozolomide Resistance-Related Molecular Mechanisms in Glioblastoma

Glioblastoma (GBM) is the most common astrocytic-derived brain tumor in adults, characterized by a poor prognosis mainly due to the resistance to the available therapy. The study of mitochondria-derived oxidative stress, and of the biological events that orbit around it, might help in the comprehension of the molecular mechanisms at the base of GBM responsiveness to Temozolomide (TMZ). Sensitive and resistant GBM cells were used to test the role of mitochondrial ROS release in TMZ-resistance. Chaperone-Mediated Autophagy (CMA) activation in relation to reactive oxygen species (ROS) release has been measured by monitoring the expression of specific genes. Treatments with H2O2 were used to test their potential in reverting resistance. Fluctuations of cytoplasmic ROS levels were accountable for CMA induction and cytotoxic effects observed in TMZ sensitive cells after treatment. On the other hand, in resistant cells, TMZ failed in producing an increase in cytoplasmic ROS levels and CMA activation, preventing GBM cell toxicity. By increasing oxidative stress, CMA activation was recovered, as also cell cytotoxicity, especially in combination with TMZ treatment. Herein, for the first time, it is shown the relation between mitochondrial ROS release, CMA activation and TMZ-responsiveness in GBM.