Miracle-dz/UniFAR-FTUs huggingface dataset:
Three-year prospective adherence to three breast cancer screening modalities.

BACKGROUND This study prospectively examined rates of adherence to mammography, clinical breast examination (CBE), and breast self-examination (BSE) in a cohort of women over 3 years to determine whether participation in BSE influenced participation in the other two screening modalities. METHODS Women ages 51 and older (n = 450) who attended a small group educational session to learn BSE and to hear about CBE and mammography guidelines were assessed annually by telephone for 3 consecutive years to determine their subsequent breast cancer screening behavior. RESULTS Annual CBE and mammography screening are highly positively associated. Regular performance of BSE has a modest positive association with both CBE and mammography adherence over time. CONCLUSIONS Women who perform BSE regularly over time may be more likely to adhere to the other breast cancer screening guidelines.
Evolution, maturation, and regression of lesions of lichen planus: New observations and correlations of clinical and histologic findings

Two hundred specimens from lesions of lichen planus were studied by conventional light microscopy in order to assess their evolution, maturation, and regression. The most important finding was that Langerhans' cells appear in increased numbers in the epidermis very early in the disease, even preceding the appearance of lymphocytes there and then that the appearance of lymphocytes is followed by destruction of keratinocytes in the lower portion of the epidermis and by general epidermal hyperplasia, including hypergranulosis and hyperkeratosis. Wedge-shaped hypergranulosis develops around intraepidermal adnexal structures, namely, acrosyringia and acrotrichia. Finally, long-enduring inflammatory-cell infiltration in the papillary dermis was found to result in eventual fibrosis there, an evidence of resolution. With time the inflammatory-cell infiltrate disappears and the epidermis regains its normal configuration. Bullous lichen planus, hypertrophic lichen planus, atrophic lichen planus, and lichen planopilaris are variants of the same pathological process, modified by intensity and location of process.
Theoria Negativa: Making Sense of Boal's Reading of Aristotle

Judging by the proliferation of recent works by and about Augusto Boal, as well as the number of course readers and critical anthologies in which his work is excerpted, his place in the canon of modern theatre theory seems assured.1 This critical consensus might almost seem too cosy given that Boal’s Theatre of the Oppressed (TO) techniques are usually regarded as a means to help effect progressive, perhaps radical social change. Thus, Douglas Paterson and Mark Weinberg (in an interview with Boal) puzzle over the fact that “people in established critical circles have not come after you. We would think there would be a ground-swell of resistance, because by taking on the Aristotelian structure, you are critiquing one of the fundamental grounds of the way western theatre is practiced” (“We Are All Theater” 18). Of course, the short answer to this puzzle is that it is no puzzle at all: Boal’s celebrated critique of Aristotle is itself firmly grounded in a theoretical position that is familiar to many “establ.
Anti-aging activities of extracts from Tunisian medicinal halophytes and their aromatic constituents

Six medicinal halophytes widely represented in North Africa and commonly used in traditional medicine were screened for pharmacological properties to set out new promising sources of natural ingredients for cosmetic or nutraceutical applications. Thus, Citrullus colocynthis, Cleome arabica, Daemia cordata, Haloxylon articulatum, Pituranthos scoparius and Scorzonera undulata were examined for their in vitro antioxidant (DPPH scavenging and superoxide anion-scavenging, β-carotene bleaching inhibition and iron-reducing tests), antibacterial (microdilution method, against four human pathogenic bacteria) and anti-tyrosinase activities. Besides, their aromatic composition was determined by RP-HPLC. H. articulatum shoot extracts exhibited the strongest antioxidant activity and inhibited efficiently the growth of Salmonella enterica and Escherichia coli. P. scoparius and C. arabica inhibited slightly monophenolase, whereas H. articulatum was the most efficient inhibitor of diphenolase activity. Furthermore, H. articulatum exhibited the highest aromatic content (3.4 % DW), with dopamine as the major compound. These observations suggest that shoot extract of H. articulatum, and to a lesser extent of C. arabica, could be used as antioxidant, antibiotic as well as new natural skin lightening agents. Also, possible implication of aromatic compounds in anti-tyrosinase activity is discussed.
The NuSTAR Extragalactic Survey: Average Broadband X-Ray Spectral Properties of the NuSTAR-detected AGNs

We present a study of the average X-ray spectral properties of the sources detected by the NuSTAR extragalactic survey, comprising observations of the Extended Chandra Deep Field South (E-CDFS), Extended Groth Strip (EGS), and the Cosmic Evolution Survey (COSMOS). The sample includes 182 NuSTAR sources (64 detected at 8–24 keV), with 3–24 keV fluxes ranging between f 3 – 24 keV ≈ 10 − 14 and 6 × 10−13 erg cm−2 s−1 ( f 8 – 24 keV ≈ 3 × 10 − 14 – 3 × 10 − 13 erg cm−2 s−1) and redshifts in the range of z = 0.04 – 3.21 . We produce composite spectra from the Chandra + NuSTAR data ( E ≈ 2 – 40 keV , rest frame) for all the sources with redshift identifications (95%) and investigate the intrinsic, average spectra of the sources, divided into broad-line (BL) and narrow-line (NL) active galactic nuclei (AGNs), and also in different bins of X-ray column density and luminosity. The average power-law photon index for the whole sample is Γ = 1.65 − 0.03 + 0.03 , flatter than the Γ ≈ 1.8 typically found for AGNs. While the spectral slope of BL and X-ray unabsorbed AGNs is consistent with the typical values ( Γ = 1.79 − 0.01 + 0.01 ), a significant flattening is seen in NL AGNs and heavily absorbed sources ( Γ = 1.60 − 0.05 + 0.08 and Γ = 1.38 − 0.12 + 0.12 , respectively), likely due to the effect of absorption and to the contribution from the Compton reflection component to the high-energy flux ( E > 10 keV). We find that the typical reflection fraction in our spectra is R ≈ 0.5 (for Γ = 1.8 ), with a tentative indication of an increase of the reflection strength with X-ray column density. While there is no significant evidence for a dependence of the photon index on X-ray luminosity in our sample, we find that R decreases with luminosity, with relatively high levels of reflection ( R ≈ 1.2 ) for L 10 – 40 keV < 10 44 erg s−1 and R ≈ 0.3 for L 10 – 40 keV > 10 44 erg s−1 AGNs, assuming a fixed spectral slope of Γ = 1.8 .
Level / Oblique Opposition and Raoyang Tonology

Phonetic experiments and phonological analysis reveal that Raoyang tone system characterizes level/oblique (LO) opposition, which is hardly captured by a node of contour in tonal geometry. A specific model featuring independent LO feature and pitch feature is then proposed. For cross-linguistic universality of tonal representation, the essay turns to the theory of Contrastive Hierarchy. Related OT constraints are then constructed and ranked for a formal grammar. The paper concludes with a discussion on the theoretical implications of this analysis.
Molecular Epidemiology of Foot-and-Mouth Disease Viruses in the Adamawa Province of Cameroon

ABSTRACT Foot-and-mouth disease virus (FMDV) causes a highly contagious viral disease of even-toed ungulates and is one of the most important economic diseases of livestock. Most studies of FMDV are done in countries where control measures are being implemented. In contrast, in areas such as sub-Saharan Africa, where FMDV is endemic and new strains are likely to emerge, there are only sporadic submissions to the World Reference Laboratory, Pirbright, United Kingdom. This paper describes the molecular epidemiology of FMDV in the Adamawa province of Cameroon based on a population sample of cattle herds. Serotypes SAT2 and A were isolated in the cross-sectional study. SAT2 isolates were all similar, with phylogenetic distances of <6%, and were most closely related to published sequences of isolates from Eritrea and Saudi Arabia. Serotype A isolates were more variable, with phylogenetic distances of 0 to 11%, and were most closely related to historic isolates from Cameroon. Use of a population-based sample gives a representative sample of virus diversity and will improve our understanding of the evolution of FMDV and its epidemiology. A supplementary study of pigs passing through the railhead collection yard at Ngaoundere detected a serotype O virus. A third pilot longitudinal study monitored viral persistence in three cattle herds over 12 months, and serotype O and A viruses were recovered from a herd 12 months after it was first recorded as being infected with SAT2 virus. The pig type O isolate was not closely related to that recovered from the cattle, suggesting that the pigs had not introduced the O virus into the cattle herds.
Chromosome-Encoded β-Lactamases TUS-1 and MUS-1 from Myroides odoratus and Myroides odoratimimus (Formerly Flavobacterium odoratum), New Members of the Lineage of Molecular Subclass B1 Metalloenzymes

ABSTRACT Myroides odoratus and Myroides odoratimimus (formerly designated in a single species as Flavobacterium odoratum) are gram-negative aerobes and sources of nosocomial infections in humans. They have variable susceptibility to β-lactams and a decreased susceptibility to carbapenems. Using genomic DNAs of M. odoratus CIP 103105 and M. odoratimimus CIP 103073 reference strains, shotgun cloning of β-lactamase genes was performed, followed by protein expression in Escherichia coli. The deduced amino acid sequences of these β-lactamase genes revealed that TUS-1 and MUS-1 from M. odoratus CIP 103105 and M. odoratimimus CIP 103073, respectively, shared 73% amino acid identity. Mature proteins TUS-1 and MUS-1, with pI values of 7.8 and 5.2, respectively, had relative molecular masses of ca. 26 kDa. These β-lactamases are members of the subclass B1 of metallo-β-lactamases and are distantly related to other metalloenzymes, being most closely related to IND-1 from Chryseobacterium indologenes (42% amino acid identity). However, phylogenic analysis showed that TUS-1 and MUS-1 belong to the same phylogenic lineage of subclass B1 enzymes that groups the subclass B1 β-lactamases of Flavobacterium species. Kinetic parameters of purified β-lactamases TUS-1 and MUS-1 detailed their hydrolysis spectra, which encompass most β-lactams except aztreonam. β-Lactamases TUS-1 and MUS-1 were classified in functional subgroup 3a of metalloenzymes. This work further characterizes chromosome-encoded metalloenzymes from Flavobacteriaceae species that explain at least part of their intrinsic resistance to β-lactams.
Decreased nocturnal melatonin levels during acute myocardial infarction

Abstract: Acute myocardial infarction is accompanied by an increase in cellular oxidative stress in the pericardial coverings of the heart. Melatonin is a highly potent and efficient radical scavenger. Little research has been carried out concerning the relationship between this antioxidant and acute myocardial infarction in humans. In this work, serum levels of melatonin and parameters of oxidative stress, such as glutathione peroxidase and lipid peroxidation levels were examined in light/dark periods in patients with acute myocardial infarction. Twenty‐five patients diagnosed with acute myocardial infarction were studied and 25 patients with no evidence of coronary artery disease served as controls. Venous blood samples were obtained from the patients and control subjects to determine melatonin, glutathione peroxidase and lipid peroxidation; the samples were collected at 10:00 hr (light period) and 03:00 hr (dark period) in the first 24 hr after admission to the coronary care unit. Our results demonstrate the existence of differences between changes in melatonin levels in control subjects and acute myocardial infarction patients, revealing a reduced nocturnal elevation in the acute myocardial infarction group. Glutathione peroxidase levels were lower after acute myocardial infarction and did not show diurnal variations. In the control group, lipid peroxidation levels presented a light/dark pattern but in the acute myocardial infarction group diurnal variations of this parameter were lost. Our data show that acute myocardial infarction is associated with a nocturnal serum melatonin deficit as well as increased oxidative stress, suggesting that melatonin is, at least in part, depleted during the dark phase to reduce the free radicals formed in acute myocardial infarction.
The Kairos Behind the Kairos Document a Contextual Exegesis of Luke 19:41-44

In this article I argue that behind the Kairos Document (KD) there is Luke's kairos or at least his view of it, which the kairos theologians did not take cognisance of Had they attempted an exegesis of Luke 19:41-44, whose spirit is partly reflected in the KD, it would have become clear that Luke's view of a kairos points back to the liberating moment of Jesus, yet forward to the consequences of missing that moment. Thus the kairos is intended for both supporters and opponents of Jesus. The new South Africa needs the positive dimension of the kairos which might provide a socio-political vision in the present context, hence the use of a contextual exegesis approach in this article.
Whatever It Takes to Win: Rivalry Increases Unethical Behavior

This research investigates the link between rivalry and unethical behavior. We propose that people will be more likely to engage in unethical behavior when competing against their rivals than when competing against non-rival competitors. Across an archival study and a series of experiments, we found that rivalry was associated with increased unsporting behavior, use of deception, and willingness to employ unethical negotiation tactics. We also explore the psychological underpinnings of rivalry in order to illuminate how it differs from general competition and why it increases unethical behavior. The data reveal a serial mediation pathway whereby rivalry heightens the psychological stakes of competition (by increasing actors’ contingency of self-worth and status concerns), which leads to the adoption of a stronger performance-approach orientation, which then increases unethical behavior. These findings highlight the importance of rivalry as a widespread, powerful, yet largely unstudied phenomenon with sign.
Epigenetic Silencing of the HIC‐1 Gene in Human Medulloblastomas

The HIC-1 (hypermethylated in cancer) candidate tumor suppressor gene is located on chromosome 17p13.3, a region frequently deleted in medulloblastomas (MBs). MBs arising in the cerebellum represent the most common malignant brain tumors in children. In this study we have analyzed the sequence, methylation, and expression status of the HIC-1 gene in MBs. Hypermethylation of the 5′UTR and/or second exon of HIC-1 was detected in 33/39 (85%) of MB biopsies and in 7/8 (88%) of MB cell lines by methylation-specific PCR. There was a significant correlation (p < 0.001) between HIC-1 methylation and lack of transcription as determined by competitive RT-PCR. Treatment of the MB cell lines Daoy and MEB-MED-8A with 5-aza-2′deoxycytidine led to re-expression of HIC-1 transcripts, indicating a silencing of HIC-1 by CpG island methylation. Mutation analysis of the coding region of HIC-1 revealed a single deletion leading to an in-frame deletion of 4 amino acids in the second exon of HIC-1 (1/68, 1.5%). Our data indicate that a significant number of MBs exhibit strikingly reduced HIC-1 expression caused by altered CpG island methylation. These data suggest that epigenetic silencing of HIC-1 may well contribute to the pathogenesis in the majority of MBs.
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Ethanol, 30 Per Cent, and Hamster Pouch Carcinogenesis

SYNOPSIS IN INTERLINGUA ETHANOL DE TRENTA PRO CENTO E CARCINOGENESE IN LE BURSA BUCCAL DEL HAMSTER. —Le influentia de ethanol in promover le disveloppamento de carcinoma oral, un effecto que se suggere clinicamente, esseva studiate experimentalmente con le utilisation de 60 hamsters auree. Le gruppo experimental de animales recipeva ethanol in un concentration de 30 pro cento como le sol provision de liquido. Le gruppo del animales de controlo recipeva aqua. Le carcinogeno, 9,10-dimethyl-1,2 benzanthraceno in oleo mineral esseva applicate in mesurate quantitates al superficie interior del bursas buccal. Post 72 dies, le incidentia de tumores maligne esseva plus alte in le gruppo recipiente ethanol. Degeneration grassiose del hepate esseva prevalente in iste gruppo. Studios additional es necessari pro confirmar le presente resultatos.
De l'espace-temps dans l'analyse du discours

Cet article decrit une approche dynamique de l'interpretation du discours qui s'interesse plus particulierement au calcul de la structure spatio-temporelle des textes. Le cadre theorique choisi est la Theorie des Representations Discursives Structurees, une extension de la DRT qui rend compte a la fois de la semantique et de la pragmatique du discours. On montre que plusieurs composants sont necessaires au processus d'interpretation. Ces composants modelisent des informations sur : la structure (rhetorique) des discours, la semantique grammaticale, la semantique lexicale, l'ontologie de l'espace-temps et la connaissance extra-linguistique sur le monde. Afin d'illustrer cette approche, des textes decrivant des trajectoires en francais sont analyses et leurs representations (denommees SDRS, pour structures de representation du discours segmentees, en anglais) sont construites.
Regulation of cell volume in health and disease.

Maintenance of a constant volume in the face of extracellular and intracellular osmotic perturbations is a critical problem faced by all cells. Most cells respond to swelling or shrinkage by activating specific metabolic or membrane-transport processes that return cell volume to its normal resting state. These processes are essential for the normal function and survival of cells. This article will outline the cellular and molecular events underlying cell-volume homeostasis and discuss their relevance to medical practice. Fundamentals of Cell-Volume Regulation Meeting Osmotic Challenges Water is in thermodynamic equilibrium across the plasma membrane. In other words, the osmotic concentrations of cytoplasmic .
Hepatic Artery Embolization and Chemoembolization for Treatment of Patients with Metastatic Carcinoid Tumors: The M.D. Anderson Experience

BACKGROUNDCarcinoid tumors have a predilection for metastasizing to the liver. The presence of liver metastases is associated with poor prognosis and also results in significant deterioration of patient's quality of life. Several reports suggest that hepatic artery embolization or chemoembolization can be used for control of liver disease in these patients. We retrospectively reviewed our experience with the use of hepatic arterial embolization or chemoembolization in patients with liver-dominant metastatic carcinoid disease, evaluating the clinical and radiologic response rates, duration of response, and progression-free and overall survival rates of these patients. MATERIALS AND METHODSThe medical records of all patients with carcinoid tumors metastatic to the liver who underwent hepatic artery embolization or chemoembolization between January 1992 and December 2000 were reviewed. For the purposes of this study, we compared the follow-up computed tomography or magnetic resonance imaging with the baseline imaging to determine each patient's objective tumor response. The interval between the dates of response and disease progression was considered the response duration. Progression-free survival duration was calculated from the date of initial treatment to the date disease progression was recorded or the date of death. Survival durations were calculated using the Kaplan-Meier method. RESULTSEighty-one patients (48 men and 33 women; age range, 38–79 years) were included in this study. The mean duration of disease from the initial discovery of liver metastases until embolization was 24.5 months. Fifty patients were treated with bland hepatic artery embolization, and 31 underwent chemoembolization. Of the 69 patients in whom radiologic response could be evaluated, partial response was observed in 46 patients (67%), minimal response (MR) in six (8.7%), stable disease in 11 (16%), and progressive disease in six (8.7%). The median duration of response in the 42 patients with partial response was 17 months (range, 4–51 months). Sixty-three percent of patients had a reduction in their tumor-related symptoms. The median progression-free survival duration was 19 months (95% confidence interval, 17–21 months); the probability of progression-free survival was 75%, 35%, and 11% at 1, 2, and 3 years, respectively. The median overall survival time was 31 months (95% confidence interval, 23–38 months); the survival probability was 93% at 1 year, 62% at 2 years, and 24% at 5 years. CONCLUSIONSHepatic arterial occlusive therapy using hepatic artery embolization or chemoembolization results in symptomatic and radiologic response in most patients with carcinoid metastases in the liver. The progression-free survival of 19 months achieved with embolization in our study is encouraging, given that most patients had extensive liver involvement and had shown disease progression while receiving systemic treatment.
Eating disorders and the role of the media.

INTRODUCTION This paper provides a review of the role of the media in the development, maintenance, prevention, and treatment of eating disorders. METHOD The literature on gambling in youth on the internet was reviewed. It explores: (1) the role of the media in providing a social context for the development of eating disorders, (2) the role of the media in the etiology of eating disorder pathology, (3) the ways in which the media is used by patients suffering from eating disorders, and (4) the role that awareness of the media can have in the treatment and prevention of eating disorders. RESULTS This review demonstrates that the media does contribute to the development of eating disorders. CONCLUSION This review highlights the need for media literacy and media activism to help change the current normative body discontent of women in the Western world.
Stationary and cyclostationary finite buffer behaviour computation via Levinson's method

A model for a finite buffer is described. The equilibrium equations for the number in the buffer have Toeplitz form. This enables Levinson's method, which is widely used in the computation of optimal linear filters, to be used to compute efficiently the distribution of the number in the buffer, for both stationary and cyclostationary systems. The method can also be used to compute distributions in other, mathematically similar, queueing problems. These include the computation of the waiting time distribution in discrete time G/G/1 queues.