Miracle-dz/UniFAR-FTUs huggingface dataset:
Trpm4 induces astrocyte swelling but not death after diffuse traumatic brain injury

Traumatic brain injury (TBI) is a prevalent disease with significant costs. Although progress has been made in understanding the complex pathobiology of focal lesions associated with TBI, questions remain regarding the diffuse responses to injury. Expression of the transient receptor potential melastatin 4 (Trpm4) channel, is linked to cytotoxic edema during hemorrhagic contusion expansion. However, little is known about Trpm4 following diffuse TBI. To explore Trpm4 expression in diffuse TBI, rats were subjected to a diffuse central fluid percussion injury (CFPI) and survived for 1.5h-8wks. The total number of Trpm4+ cells, as well as individual cellular intensity/expression of Trpm4, were assessed. Hemotoxylin and eosin (H&E) labeling was performed to evaluate cell damage/death potentially associated with Trpm4 expression following diffuse TBI. Finally, ultrastructural assessments were performed to evaluate the integrity of Trpm4+ cells and the potential for swelling associated with Trpm4 expression. Trp.
Early Object Omission in Child French and English

We examine the syntactic nature of object omissions in child language with a study comparing French and English-speaking children’s elicited production. We adopt a theoretical approach to transitivity where interactions between modules of the grammar create a rich and flexible system of null objects in French (category N or pro ); whereas a language like English contains only the former. The different complexity in the input predicts acquisitional differences between the two languages. Children heard stories with an individuated object referent ( What did X do with y? ) and stories that did not individuate an object referent ( What did X do? ) . Results show that French children had substantially higher rates of omissions in both illicit and optional null object contexts than either French adults or English speaking children. We propose that French children, faced with a variety of null objects in the input, retain the minimal null N, overextending it beyond adult distribution.
Induction of labour: eternal controversy

Induction of labour (IOL) is one of the most frequently used techniques in current obstetrics. According to WHO, 25% of all deliveries in developed countries are induced. Generally, developing countries have lower rates of IOL [1]. The goal is to get the advancement of the delivery before its spontaneous evolution. There are many controversies on this procedure and; therefore, dissimilar guides are used in different hospitals. In addition, it is not a harmless technique and for this reason it is important to have adequate protocols in order to optimize resources and diminish risks [2]. In this review, we present the main controversies related to IOL.
Optimal transversal filter bank for 3D real-time acoustical imaging

An optimal transversal filter bank for parallel processing of echo data in 3-D real-time acoustical imaging is proposed. It is based on discretized linear time-domain formation of the imaging equation for systems that use either coded-aperture transducers or transmitter arrays with coded-excitation. The two approaches are mathematically equivalent and result in an imaging system architecture which is based on parallel processing of a sampled vector of echo data with a bank of transversal filters. The filter coefficients are obtained through a pseudoinverse operator which is designed to decouple echoes received from different image lines. <<ETX>>
Treating anxious expectations can improve dyspnoea in patients with COPD

Chronic obstructive pulmonary disease (COPD) is a worldwide leading cause of morbidity and mortality and associated with great individual, societal and economic burden [1]. Dyspnoea is the threatening cardinal symptom and related to a worse course of COPD, including drastic reductions in quality of life and even increased mortality risk [2, 3]. Dyspnoea is a multi-dimensional subjective experience that encompasses not only the perception of sensory signals (dyspnoea intensity), but also important immediate and long-term affective aspects (dyspnoea unpleasantness, dyspnoea anxiety, suffering) [2–4]. In many patients, dyspnoea can be persistent, despite optimal treatment efforts, which was recently termed “chronic breathlessness syndrome” [5]. Notwithstanding, reducing dyspnoea is a major treatment goal in COPD [6] and neglecting it has previously been discussed in a thought-provoking article in this journal as a potential violation of human rights [7]. The detection and treatment of anxious expectations can improve dyspnoea in patients with COPD http://ow.ly/jnBR30efnhj
Reasons for Not Treating Women with Postmenopausal Osteoporosis with Prescription Medications: Physicians' and Patients' Perspectives.

Abstract Background: In the United States, between one-third and two thirds of postmenopausal women do not begin treatment with a prescription osteoporosis medication after a diagnosis of osteoporosis. The objective of this study was to understand the reasons for this lack of treatment. Materials and Methods: Online physician and patient surveys were administered in 2013. The physician survey included a chart review of untreated postmenopausal women recently diagnosed with osteoporosis and gathered data on physicians' practices regarding the management of osteoporosis in postmenopausal women. The patient survey was given to untreated postmenopausal women with a recent osteoporosis diagnosis. Results: The physician survey was completed by 224 physicians, who also reviewed 811 patient charts. A total of 165 patients completed the patient survey. In the chart review, physicians reported that 19% of the postmenopausal women they diagnosed with osteoporosis were not prescribed an osteoporosis medication. The p.
Clinical and Angiographic Features of Patients with Coronary Artery Ectasia Compared with Stenotic Coronary Artery Disease

Coronary artery disease (CAD) is a major cause of morbidity and mortality worldwide. Each year, an estimated 635,000 Americans have a new coronary attack (defined as first hospitalized myocardial infarction (MI) or coronary heart disease related death) and 280,000 have a recurrent attack [1]. Coronary artery ectasia (CAE) is a relatively common entity but its prevalence and relevance are not as well studied in the Middle Eastern region. In other parts of the World its prevalence varies from 1.5 to 5% Volume 9 Issue 4 2017
Primary Mucinous Adenocarcinoma of the Eyelid: The First Reported Case in the Middle East

A 57-year-old male, presented to the oculoplastic clinic with a 2-years history of progressive slowly growing slightly pigmented left lower eyelid mass that was associated with occasional discharge and has been clinically thought to be a benign nevus. The patient denied any history of surgery or trauma related to the site of the lesion. There was no history of pain or visual disturbance. The patient had systemic diabetes mellitus, hyperlipidemia and bronchial asthma.
HSP90 Inhibition Enhances the Anti-Tumor Efficacy of Combination Chemo Immunotherapy Targeting DNA Repair Proteins

Submit Manuscript | http://medcraveonline.com Abbreviations: ACT: Adoptive Cellular Therapy; ATM: Ataxia Telangiectasia Mutated Protein; ATR: ATM and Rad3-Related Protein; BRAF: B-Raf proto-oncogene; BRCA: Breast Cancer; CFDA-SE: Carboxy Fluorescein Diacetate Succinimidyl Ester; CFSE: Carboxy Fluorescein Succinimidyl Ester; CHEK: Checkpoint kinase; CM: Culture Medium; CTLA-4: Cytotoxic TLymphocyte Associated protein 4; DC: Dendritic Cell; DNA-RP: DNA Repair Proteins; DMSO: Dimethyl Sulfoxide; DOX: Doxorubicin; ELISA: Enzyme-Linked Immuno Sorbent Assay; FMOC: Fluorenyl Methoxy Carbonyl; HDAC: Histone Deacetylase; HIP: Hsp70 Interacting Protein; HOP: Hsp70-Hsp90 Organizing Protein; HSP: Heat Shock Protein; HSP90i: HSP90 Inhibitor; DSB: Double-Strand Breaks; IFN: Interferon; IL: Interleukin; MACS: Magnetic-Activated Cell Sorting; MART1: Melanoma Antigen Recognized by T cells 1; MHC: Major Histo Compatibility; MRE 11: Meiotic Recombination Protein 11; MRN: MRE11–RAD50–NBS1, NBN: Nibrin; PD1: Programmed Cell Death Protein 1; PD-L1: Programmed DeathLigand 1; PRKDC: Protein kinase DNA-activated Catalytic polypeptide; QPCR: Quantitative Polymerase Chain Reaction; SDS-PAGE: Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis; TIL: Tumor-Infiltrating Lymphocytes; TME: Tumor Microenvironment; TMZ: Temozolomide; TRP: Tyrosinase Related Protein; TUNEL: Terminal Deoxynucleotidyl Transferase dUTP Nick End Labeling
Supervised dictionary learning for action recognition and localization

Image sequences with humans and human activities are everywhere. With the amount of produced and distributed data increasing at an unprecedented rate, there has been a lot of interest in building systems that can understand and interpret the visual data, and in particular detect and recognise human actions. Dictionary based approaches learn a dictionary from descriptors extracted from the videos in the first stage and a classifier or a detector in the second stage. The major drawback of such an approach is that the dictionary is learned in an unsupervised manner without considering the task (classification or detection) that follows it. In this work we develop task dependent(supervised) dictionaries for action recognition and localization, i.e., dictionaries that are best suited for the subsequent task. In the first part of the work, we propose a supervised max-margin framework for linear and non-linear Non-Negative Matrix Factorization (NMF). To achieve this, we impose max-margin constraints within the formulation of NMF and simultaneously solve for the classifier and the dictionary. The dictionary (basis matrix) thus obtained maximizes the margin of the classifier in the low dimensional space (in the linear case) or in the high dimensional feature space (in the non-linear case). In the second part the work, we develop methodologies for action localization. We first propose a dictionary weighting approach where we learn local and global weights for the dictionary by considering the localization information of the training sequences. We next extend this approach to learn a task-dependent dictionary for action localization that incorporates the localization information of the training sequences into dictionary learning. The results on publicly available datasets show that the performance of the system is improved by using the supervised information while learning dictionary.
An Evaluation of Heuristic Methods for Determining Optimal Link Capacity Expansions on Road Network

Since the bilevel formulation of the Continuous Network Design Problem (CNDP) has the characteristic of a non-convex optimization problem, heuristic methods are usually the preferred option for solving it. On the other hand, the computation time is crucial importance for solving the CNDP because the algorithms implemented on real sized networks require solving traffic assignment model many times, in which algorithms spend more time in comparison with the other parts of the solution process. Therefore, solving the CNDP with less number of traffic assignments can be assessed as one of the most important topics in the transportation field. Thus, the paper deals with analyzing the performance of recently developed heuristic methods in solving the CNDP. In this study, the capability of Harmony Search (HS), Artificial Bee Colony (ABC) and Differential Evolution (DE) algorithms for solving the CNDP is evaluated, and numerical calculations are performed on example test networks. The results obtained through the HS, ABC and DE algorithms on 18-link network are compared with those generated by two different heuristic methods, which are available in a previous study. Additionally, the performance of the proposed heuristics is compared on Sioux Falls city network with other major algorithms available in the literature. Numerical examples have clearly indicated that the DE shows good performance in comparison with the proposed algorithms in terms of both objective function value and required computational effort.
How task instructions impact the creativity of designers and ordinary participants in online idea generation

Online idea generation platforms are increasingly used to generate ideas of innovative products. Crafting the problem statement carefully is a key factor of success, however, the current literature remains limited concerning what kind of task instructions should be used to increase the quality of ideas in online idea generation. This research examines three different types of task instructions. The unbounded task instructions allowed participants generating the ideas they wish without any restriction. The suggestive task instructions indicate domains of ideas that are innovative. The prohibitive task instructions indicate domains of ideas that are not innovative. The impact of these three types of task instructions on creative outcomes is compared through an empirical study on eYeka, a global online idea generation platform. Based on logit models, we found that the task instructions have a significant impact on the creativity of participants. Our result shows that prohibitive task instructions enable the production of the most original ideas whereas suggestive task instructions favor the production of the most feasible and valuable ideas. Unbounded task instructions are mostly found to be inefficient. The implications for the management of online idea generation communities are discussed. 2 " The formulation of a problem is often more essential than its solution, which may be merely a matter of mathematical or experimental. " A. Einstein, L. Infeld in The Evolution of Physics (p.92).
The development of antiplatelet therapy after percutaneous coronary intervention

Coronary artery disease (CAD) is a common disease and has an impact in all over the word. With the development of life level and life style, the incident of morbidity and mortality largely increased [1]. Atherogenesis and the formation of thrombi are the main risk events. The application of percutaneous coronary intervention (PCI) released coronary artery disease and improved patients’ quality of life. The mortality of acute coronary syndrome (ACS) was obviously reduced [2]. The stent style including baremetal stents (BMS) and drug-eluting stents (DES) benefited many patients in clinic [3]. Antiplatelet therapy is standard treatment after PCI. Meanwhile, international guidelines and clinical practice recommend dual antiplatelet therapy (DAPT aspirin combination with P2Y12 inhibitors) after PCI [4,5]. Previous clinical application indicated that DES reduced major advent cardiac such as death, non-fatal myocardial infarction target lesion revascularization [6]. But the risk of stent thrombosis was increased, especially late stent thrombosis [7]. Therefore, in order to prevent stent thrombosis, prolonged antiplatelet therapy was recommended by clinical guidelines. Then DAPT combination of aspirin with P2Y12 inhibitors (clopidogrel, prasugrel, ticagrelor) used to reduce the risk of stent thrombosis and adverse cardiac outcomes. However, the optimal duration of DAPT after coronary drug-eluting stent implantation remains debated. It will elevate stent thrombosis if stopping DAPT too early. For the other side, delaying DAPT will increase patients’ burden and reduce patients’ compliance; what’s more, the complication of bleeding will increase and it affects some surgeries. It is a challenge for clinician to balance the advantages and disadvantages.
Investigation of the effects of various antibiotics against Klebsiella pneumoniae biofilms on in vitro catheter model

Klebsiella pneumoniae continues to be an important cause of community-acquired and nosocomial infection. This bacterium can cause catheter related infections by forming biofilm on the surface of catheter. The aim of our study is to determine the in vitro stability and efficacy of colistin, ciprofloxacin, tobramycin, doripenem and tigecycline alone, or in combination with clarithromycin or esomeprazole, as 24-h lock solutions against biofilm-embedded K. pneumoniae strains. The efficacy of antibiotic lock solutions was tested in an in vitro catheter biofilm model against K. pneumoniae. In our study, we observed that the use of doripenem and tobramycin as a lock solution had potent bactericidal effects. When colistin was used in combination with clarithromycin or esomeprazole, the combinations had a synergistic effect. No antagonistic effect was observed. The findings of our study have important information for effectiveness of tested antibiotic lock solution in the catheter-related infections with K. pneumoniae.
Treatment of Essential Tremor with Multi-Modal Nutritional Therapy in a Teenage Patient

Essential tremor (ET) the most common movement disorder, affecting 1% of the population across all ages and a significantly higher proportion of older adults [1]. However, ET also affects children, and, although often described as “benign”, the condition interferes with activities of daily living in over 90% of individuals [2]. Pharmacological therapy remains first-line ET treatment, with propranolol (a beta-blocker) and primidone (a barbiturate anti-convulsant) first-choice agents [3]. However, over 50% of patients do not respond to therapy and many experience sideeffects including sleepiness and cognitive defects, prompting nonadherence to medication in many cases [4].
Sinnvolle Steroidprophylaxe bei drohender Frühgeburt – State of the art

Zusammenfassung Die vorliegende Arbeit versucht, anhand der aktuellen Literatur eine Übersicht über die zurzeit geltenden Empfehlungen zur sinnvollen Lungenreife-Induktionstherapie zu geben. Fokussiert wird insbesondere auf spezielle Situationen, wie die Chorioamnionitis, die intrauterine Wachstumsretardierung und die Präeklampsie, die gehäuft zu einer Frühgeburt führen. Zusätzlich werden Aspekte der antenatalen Steroidtherapie erläutert, die trotz der weit verbreiteten Anwendung noch einer Klärung bedürfen. Darunter fällt insbesondere die repetitive Gabe der Steroidtherapie. Anhand der Cochrane Analyse vom 2015 werden Vor- und Nachteile für die Kinder und die Schwangeren erläutert. Ungenügend sind weiterhin die Daten über die Anwendung der antenatalen Steroidtherapie bei Mehrlingsschwangerschaften.
Enhancing Students' Geometric Thinking and Achievement in Solid Geometry

This study aimed to explore if students’ geometric thinking and achievement in solid geometry could be enhanced through phase-based instruction using manipulatives and The Geometer’s Sketchpad (GSP) based on the van Hiele theory. The researchers employed a case study research design and purposeful sampling to select eight case study participants from a class of mixed-ability Form One students. The results showed that the teaching intervention could enhance the participants’ geometric thinking and achievement in solid geometry.
SPARE PARTS ESTIMATION FOR MACHINE AVAILABILITY IMPROVEMENT ADDRESSING ITS RELIABILITY AND OPERATING ENVIRONMENT — CASE STUDY

Industrial operation cost analysis shows that, in general, maintenance represents a significant proportion of the overall operating costs. Therefore, the improvement of maintenance follows the final goal of any company, namely, to maximize profit. This paper studies spare parts availability, an issue of the maintenance process, which is an important way to improve production through increased availability of functional machinery and subsequent minimization of the total production cost. Spare parts estimation based on machine reliability characteristics and operating environment is performed. The study uses an improved statistical-reliability (S-R) approach which incorporates the system/machine operating environment information in systems reliability analysis. For this purpose, two methods of Poisson process and renewal process are introduced and discussed. The renewal process model uses a multiple regression type of analysis based on Cox's proportional hazards modeling (PHM). The parametric approaches with baseline Weibull hazard functions and time-independent covariates are considered, and the influence of operating environment factors on this model is analyzed. The outputs represent a significant difference in the required spare parts estimation when considering or ignoring the influence of the relevant system operating environment. The difference is significant in the sense of spare parts forecasting and inventory management which can enhance the parts and consequently machine availability, leading to economical operation and savings.
The effect of biofeedback training on anxiety in physical education Teachers short title: biofeedback training and PE teacher’s anxiety

Material and methods: A total of 57 PE teachers, age 25-59 years (M=40.5±9.02), volunteered to participate in the current study. The participants were graduate (MEd) students at an academic college in the southern part of Israel. The participants were randomly divided into three groups: LMA (n=20), BFB relaxation games (n=22); and Control (n=15). Two questionnaires were used to measure anxiety: the State-Trait Anxiety Inventory (STAI) and the Sport Competition Anxiety Test (SCAT). The research protocol included 21 sessions, each lasting 60 minutes.
The Effect of Internal Marketing on Customer Orientation of Employees: the case of Selected Star Hotels in Addis Ababa

In the organization of services like hotel as the factors that can be important to improving quality of services, one is internal marketing. An Internal marketing activities in the development of an important organization is creating customer oriented employees. The main aim of internal marketing is having the knowledge of the internal and external customers and removing the obstacles in the way to value and quality of services. The purpose of this research is to investigate the effect of internal marketing on employee’s customer orientation in star hotels which are found in Addis Ababa. The study is conducted with the objective of answering four basic questions i.e. to investigate the effect of motivation, empowerment, communication and training & development on customer orientation. In this research the researcher follows a deductive approach. This research is a descriptive and explanatory type of research. A quantitative method was used, whereby questionnaire was distributed to the employees of star hotels that are selected for the study. The effect of internal marketing on customer orientation was analyzed using bivariate correlation and standard multiple regression. This study used IBM SPSS software to conduct a bivariate correlation and standard multiple regression procedures to answer the basic research questions. The result indicates that all selected dimensions of internal marketing have positive and significant relation with customer orientation. Therefore, the hotels are recommended to consider implementing internal marketing principles to increase customer orientation of employees as it is one of the competitive advantages of an organization to remain competitive in such dynamic, ambiguous and turbulent business environment.