Miracle-dz/UniFAR-FTUs huggingface dataset:
An Investigation on the Therapeutic Potential of Butein, A Tretrahydroxychalcone Against Human Oral Squamous Cell Carcinoma

Background: Oral squamous cell carcinoma (OSCC) is one of the most predominant cancers in India. With advances in the field of oncology, a number of therapies have emerged; however, they are minimally effective. Consequently, there is a need to develop safe and effective regimens for the treatment of OSCC. Butein, a tetrahydroxychalcone has been found to exhibit potent antioxidant, anti-inflammatory, and also anti-tumor effects against several cancer types. However, its effect on OSCC is not studied yet. Methods: The effect of butein on the viability, apoptosis, migration and invasion of OSCC cells was evaluated using MTT, colony formation, PI/FACS, live and dead, scratch wound healing, and matrigel invasion assays. Further Western blot analysis was done to evaluate the expression of different proteins involved in the regulation of cancer hallmarks. Results: This is the first report exemplifying the anti-cancer effect of butein against OSCC. Our results showed that butein exhibited potent anti-proliferative, cytotoxic, anti-migratory, and anti-invasive effects in OSCC cells. It suppressed the expression of NF-κB and NF-κB-regulated gene products such as COX-2, survivin and MMP-9 which are involved in the regulation of different processes like proliferation, survival, invasion, and metastasis of OSCC cells. Conclusion Collectively, these results suggest that butein has immense potential in the management of OSCC. Nonetheless, in vivo validation is critical before moving to clinical trials.
Caution at choosing a particular colony‐forming unit from faecal Escherichia coli: it may not represent the sample profile

Data about phylogenetic classification of Escherichia coli colonizing calves, lambs and foals are routinely neglected and restricted to outdated methodologies, even in the context of antimicrobial susceptibility (AS) testing. Thus, the aim of this study was to determine the phylogenetic diversity and the AS profile of E. coli colony‐forming units (CFUs) from faecal samples of healthy animals. Five CFUs of E. coli were randomly selected from each faecal culture of calves (n = 13), foals (n = 13) and lambs (n = 13), totalizing 195 CFUs phylo‐typed by quadruplex PCR. The AS profile of five CFUs from 15 samples (five from each animal species; n = 75 isolates) against nine drugs was determined by agar diffusion test. We found E. coli belonging to all phylo‐groups already described, except D group, with the predominance of B1 (65% CFUs; 126/195) in the three‐animal species sampled. Most faecal samples of calves (77%; 10/13) and foals (69%; 9/13) harboured both pathogenic and nonpathogenic E. coli. All faecal samples showed CFUs with diverse AS profile, highlighting the ineffectiveness of tetracycline, sulphonamide and ampicillin. As a key point, our data reinforce the importance to select at least four E. coli CFUs for AS testing.
Explaining Perceived Priorities in Women with Breast Cancer: A Qualitative Study

Objective: Cancer is a stressful event in life, and the dreadful impact and problems created for patients and families by cancer negatively affect their quality of life. Therefore, regarding the increasing number of cancer patients and the nature of this disease, the need to recognize and understand the priorities and problems of patients after the diagnosis of cancer is of high importance. This study was designed and implemented with the aim of identifying the perceived priorities of women with breast cancer. Methods: This study is a qualitative research of content analysis type. To collect data, purposeful sampling and deep semi-structured individual interviews were used. The subjects were women with breast cancer who visited the Breast Disease Research Center of Shahid Motahari Clinic in Shiraz, and the data were saturated after 15 interviews. The four criteria presented by Lincken and Guba were used to evaluate the validity and reliability. To analyze the qualitative data, conventional qualitative data analysis and MAXQDA10 software were used. Two themes were obtained in the assessment of interviews and analysis of data: 1) Supportive relief; 2) Therapeutic support. Results: Some of the participants highlighted the role of social and family support in coping with the disease, and considered social communication and continued support in the form of empathic relationship as a turning point in their lives. The absence of a fertility specialist in the cancer treatment system was the main complaint of most participants. The results showed that receiving support from family and the healthcare system is the most important perceived priorities in breast cancer patients. Conclusion: The results of this study show the importance of social support as a perceived priority in breast cancer patients to improve their quality of life. Development and reinforcement of the supportive network seem to be essential to provide the best possible help to these patients.
The effect of intermittent sequential pneumatic compression on recovery between exercise bouts in well-trained triathletes.

To evaluate the effectiveness of one method of intermittent sequential pneumatic compression (ISPC) on the recovery between exercise bouts in well-trained triathletes. Ten well-trained male triathletes (mean Â± SD; age = 29 Â± 9 y, mass = 72kg Â± 11kg) completed a familiarization trial and two experimental trials in a randomized, cross-over design. Participants performed a 40-minute high-intensity interval session on a cycle ergometer, followed by a 30- minute recovery period where participants completed either passive recovery (CON) or ISPC recovery. Following the recovery period, participants performed a 5km run time-trial on a treadmill (5kmTT). Blood lactate concentration, 5kmTT time and total quality recovery (TQR) were used to examine the effect of ISPC compared to CON. The 5kmTT resulted in a non-significant difference (P = 0.31, ES = 0.07) between groups of 8.2 Â± 23.7 seconds in favour of the ISPC trial (ISPC; 1189.7 Â± 94.9 and CON; 1197.9 Â± 101.9). There were no significant differences between trials for blood lactate concentrations or TQR. The current study reports that ISPC was not effective in improving recovery between a cycling and running bout in well-trained triathletes. Â
The Sympathetic Nervous System Regulates Inflammation in Amoebic Liver Abscess in Hamsters

An inflammation is generated during formation of Amoebic Liver Abscess. We analyzed chemically sympathectomized hamsters with Amoebic Liver Abscess, in a period between 6 hours to 7 days. The liver tissue samples were analyzed by haematoxylin and eosin staining, immunohistochemistry, immunofluorescence and morphometry. Sympathectomy caused a lower production of collagen and absence of granuloma tissue of Amoebic Liver Abscess. At the 6 h of development, proinflammatory cytokines were reduced, also reduced 12 hours – 7 days; while IL-10 production was incresed for this time; Transforming Growth Factorproducing cells only increased from 4 to 7 days. Nuclear factor kappa-light-chain-enhancer of activated B cells were diminished throughout the Amoebic Liver Abscess, while Toll Like Receptor 4 + macrophages decreased in the period of 2 to 7 days; and Toll Like Receptor 4 + neutrophils decreased between 4 and 7 days. The population of trophozoites was increased in sympathectomized animals between 4 and 7 days. The chemical sympathectomy reduces the collagen deposition and induces an anti-inflammatory state during the development of Amoebic Liver Abscess, then; allows the spread and reproduction of Entamoeba histolytica trophozoites.
Effect of physical training on the blood pressure of adolescents with obesity

Objective: To systematically review the results of studies that analyzed the effects of physical training on the blood pressure of obese adolescents. Data sources: A systematic review of randomized clinical trials was performed and examined the effect of physical training on the blood pressure of obese adolescents, published in journals indexed at PubMed/Medline, Lilacs, SciELO, and ISI Web of Knowledge SM databases. Studies that evaluated adolescents published until 2010 and that had a Control Group were included. Data synthesis: Eight studies met the inclusion criteria. Two of them used strength exercises combined with aerobics, while six used only aerobics. Five studies used complementary intervention, especially nutritional. Four studies found decreased systolic blood pressure in the Training Group compared to Controls, together with the reduction in body mass. All studies that found a reduction in systolic blood pressure used aerobic exercises from 12 to 24 weeks three to six times per week, lasting 50 to 90 minutes, and with intensity between 55 and 75% at the maximum heart rate. Conclusions: The effect of physical training on the systolic blood pressure of obese adolescents is controversial. However, the reduction in systolic blood pressure seems to occur with aerobic training programs, that also reduce body mass.
Prevalence of primary drug resistance in pulmonary tuberculosis patients with no known risk factors for such.

OBJECTIVE To estimate the prevalence of primary resistance to the drugs in the basic treatment regimen for tuberculosis in treatment-naïve patients with pulmonary tuberculosis and no known risk factors for such resistance, as well as to identify factors potentially associated with drug resistance. METHODS This was an exploratory cross-sectional study. We analyzed the medical records of the subjects enrolled in two clinical trials of treatments for drug-susceptible tuberculosis between November 1, 2004 and March 31, 2011 at the Prof. Newton Bethlem Outpatient Clinic of the Federal University of Rio de Janeiro Thoracic Diseases Institute, located in the city of Rio de Janeiro, Brazil. The inclusion criteria were being > 18 years of age, testing positive for AFB in the first sputum sample, having a positive culture for Mycobacterium tuberculosis, having undergone drug susceptibility testing, and being treatment-naïve. Patients with a history of imprisonment or hospitalization were excluded, as were those who had been in contact with drug-resistant tuberculosis patients. RESULTS We included 209 patients. The overall prevalence of primary drug resistance was 16.3%. The overall prevalence of resistance to isoniazid and streptomycin was, respectively, 9.6% and 9.1%, compared with 5.8% and 6.8% for single-drug resistance to isoniazid and streptomycin, respectively. The prevalence of resistance to two or more drugs was 3.8%, and the prevalence of multidrug resistance was 0.5%. No statistically significant associations were found between the variables studied and drug susceptibility testing results. CONCLUSIONS In this sample, the prevalence of primary drug resistance was high despite the absence of known risk factors.
The consumption of low glycemic meals reduces abdominal obesity in subjects with excess body weight.

OBJECTIVE To evaluate the effect of the glycemic index (GI) on food intake, anthropometric measurements and body composition in subjects with excess body weight. METHODS Crossover study, in which 17 subjects participated in two study sessions (high GI or low GI). Two daily meals were consumed in laboratory for 30 consecutive days in each session. Subjects also consumed under free living conditions 3 daily isocaloric servings of fruits, presenting the same GI as the session in which they were participating. At each 15 days, subjects were submitted to body composition (lean mass and fatty mass) and anthropometric indexes (weight, height, body mass index, waist circumference (WC), hip circumference, hip-waist relation (WHC)) assessment. Habitual food intake was assessed before and at the end of each session. Subjects were instructed to maintain the same level of physical activity during the study. RESULTS There was a significant reduction on WC and WHC after the low GI session. The other parameters did not differ between the treatments applied in this study. CONCLUSION These results suggest that the consumption of low GI foods may favor the prevention and control abdominal obesity and the associated metabolic diseases.
Impact of correcting peak flow for nonlinear errors on air pollutant effect estimates from a panel study

Air pollutant effects are commonly investigated using panel studies employing daily measurement of changes in peak expiratory flow (PEF). Variable orifice PEF meters are inaccurate with a nonlinear relationship to actual PEF. The impact on a panel study of correcting these errors was examined. Twice-daily PEF readings were taken by 147 9-yr old children for 8 weeks and corrected using an equation derived from the response of 32 Vitalograph meters to a servomechanism-controlled pump. Pollutant effect estimates for corrected and uncorrected readings were derived using a regression approach incorporating appropriate confounders. Correction impacted little on mean PEF values (333.1-334.2 L x min(-1)), but did alter effect sizes. Nonsignificant nitrogen dioxide estimates for the entire panel decreased by up to 73%, but, for symptomatic/atopic children, a significant 5-day mean result was lost (decrease in effect size from -2.53 to -0.90% per 10 parts per billion (ppb)) and lag 0 became significant (decrease from -0.51 to -1.22% per 10 ppb). Mass concentration estimates of particles with a 50% cut-off aerodynamic diameter of 2.5 microm moved in both directions (-0.22 changed to 0.11% per 10 microg x m(-1) lag 3 and -0.29 to -0.73% per 10 microg x m(-3) for the 5-day mean). Correction of nonlinearity of peak expiratory flow meters influenced the overall outcome of this panel study, and the changes in effect estimates would be sufficient to alter the interpretation of some studies. For adults, a greater change in effect estimates may follow the larger correction required for their usual peak expiratory flow range.
Type and Portions of Peripheral Blood T Lymphocytes in Oral Lichen Planus

Background: Lichen planus is a disease with unknown etiology that affects the skin and the mucous membranes. Immune dysregulation in the pathogenesis of oral lichen planus (OLP) is well-known phenomenon. Objectives: In this study, we compared the levels of the peripheral blood T lymphocytes between patients with OLP and control group. Patients and Methods: In this study, 32 and 16 patients respectively with and without OLP were recruited. Five milliliters of the participants' peripheral venous blood was drew in an EDTA-containing test tube and the levels of CD3+, CD4+, and CD8+ cells, CD4+/CD8+ and CD4+/ CD3+ ratio were measured by means of two-color flow cytometry. The data were analyzed in SPPS v.19 by employing Mann-Whitney U test. Results: There were no significant difference among the levels of CD3+, CD4+, and CD8+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes between patients and control group; however, there was a significant difference between male and female patients with respect to the levels of CD3+ and CD4+ lymphocytes and the ratio of CD4+/CD8+ and CD4+/CD3+ lymphocytes. Conclusions: Our results confirm that only local immune mechanism known as skin-associated lymphoid tissue, not a systemic immunologic disorder, was involved in the OLP.
The umbilical cord thickness measured at 18–23 weeks of gestational age

Objective. To establish an umbilical cord thickness nomogram from anatomy ultrasound scans performed between 18 and 23 weeks of gestational age in singleton pregnancies, and compare it to two previously published nomograms.Material and methods. In this retrospective cohort study of 1107 patients, a total of 650 singleton pregnancies were included. The umbilical cord diameter measurements were performed at the level of fetal abdominal wall insertion, and were correlated with gestational age (GA) and estimated fetal weight (EFW). Statistical analysis with non-parametric polynomial least squares regression analysis was performed.Results. A statistically significant correlation between umbilical cord diameter and GA (P? <? 0001, r? =? 0.399, 95% CI 0.331 to 0.464), and EFW (P? <? 0001, r? =? 0.420, 95% CI 0.353–0.483) was observed. A nomogram of umbilical cord thickness according to GA (y), and EFW (y’), was generated from the following equations:y? =? -51.30? +? 5.367*x-0.1165*x2 and y'? =? 6.917? +? 0.007233*x, respectively.Conclusion. Our nomogram is in agreement with one of the previously published nomograms that also measured umbilical cord diameter at the level of the fetal abdominal umbilical cord insertion. Therefore, we recommend umbilical cord thickness to be measured in close proximity to the fetal abdominal wall, but no further than 0.5? cm away from the wall insertion.
Targeting NF-κB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells

Acute myeloid leukemia (AML) cells are characterized by a constitutive and abnormal activation of the nuclear factor-κB (NF-κB) transcription factor. This study, conducted in vitro on 18 patients, shows that targeting the IKB kinase 2 (IKK2) kinase with the specific pharmacologic inhibitor AS602868 to block NF-κB activation led to apoptosis of human primary AML cells. Moreover, AS602868 potentiated the apoptotic response induced by the current chemotherapeutic drugs doxorubicin, cytarabine, or etoposide (VP16). AS602868-induced cell death was associated with rupture of the mitochondrial transmembrane potential and activation of cellular caspases. NF-κB inhibition did not affect normal CD34+ hematopoietic precursors, suggesting that it could represent a new adjuvant strategy for AML treatment.
Prevalence of Work-Related Upper Limbs Symptoms (WRULS) Among Office Workers

An analytical cross-sectional study was carried out to determine the prevalence of work-related upper limbs symptoms (WRULS) among office workers and factors associated with it. A self-administered questionnaire was used to collect the information. A total of 463 (87.7%) office workers from selected government agencies participated in this study. The mean age of the respondents was 34.1 years (range = 18-55 years). Majority (91.6%) were Malay and female (72.8%), and 58.1% were from clerical group. Mean duration of work was 8.7 years. This study found that prevalence of WRULS was 33.0% (95% CI [confidence interval] = 28.8%, 37.3%). Computer users at work had 2.0 (95% CI = 1.1, 3.4) higher odds ratio of developing WRULS and those who used it for 5 hours and more per day had 7.5 (95% CI = 2.3, 24.2) higher odds ratio of developing WRULS. Hand-intensive hobbies and higher education were also found to be associated with WRULS.
Canadian Journal on Aging / La Revue canadienne du viellissement 24 (4) : 353-366

This article presents the results of a study into stereotyping by managers of their older workers and the influence of these stereotypes on the inclination of managers to keep their older workers in employment. The data for the study were gathered among 796 managers. Through principal components analysis, 15 opinions about older workers were reduced to three dimensions of stereotypes. The first dimension deals with the productivity of older staff; the other two dimensions have to do with their reliability and their adaptability. These stereotypical ideas about older workers influence managers’ attitudes toward the retirement of their employees. The analyses show that, besides organizational factors, psychological mechanisms also explain why people view older workers through stereotypes. Managers who are older and in more frequent contact with older employees tend to hold more positive views. * Leo van Wissen was extremely helpful with statistical advice. Comments by Harry van Dalen, Rob Ranzijn, and Petra Visser are gratefully acknowledged. Manuscript received: / manuscrit reçu : 23/03/04 Manuscript accepted: / manuscrit accepté : 11/07/05 Mots clés : vieillissement; stéréotypes; employés âgés; retraite; Pays Bas; vieillissement de la main d’œuvre
Graph Theory Based Functional Connectivity in Lateralized Temporal Lobe Epilepsy (I1-1.005)

Objective To characterize abnormal brain networks in temporal lobe epilepsy (TLE) and study differences between right and left TLE using graph theoretical methods. Background TLE is the most common form of epilepsy in adults and the most common form of pharmaco-resistant epilepsy. Surgical treatment can provide effective treatment, but determining surgical candidacy and maximizing surgical outcome is often hindered by the lack of precision of current techniques in identifying the epileptogenic zone. Functional connectivity MRI (fcMRI) provides an additional potentially useful test to aid identification of differences in the distribution of lateralized TLE. Design/Methods Graph theoretical methods were applied to resting state fcMRI data from 14 patients with left TLE, 8 patients with right TLE, and 9 healthy individuals. Functional connectivity between 90 brain regions was estimated using Pearson correlation and thresholded over a range of connection densities to construct a set of undirected graphs. Global and regional network properties were computed for TLE subgroups and compared to healthy individuals. Correlations between epilepsy duration and network properties were compared for TLE subgroups. Results Global topological properties were altered in both right and left TLE subgroups compared to controls, including connectivity strength, connectivity diversity, clustering coefficient, and small-world index, and these were more affected in right TLE. Within the temporal lobe, medial temporal structures showed reduced connectivity, whereas lateral temporal structures were relatively preserved. Regional topological properties showed more changes in connectivity for left TLE within the medial temporal lobe and for right TLE outside the temporal lobe. Longer epilepsy duration was significantly correlated with decreases in connectivity and efficiency in both right and left TLE. Conclusions Global and local connectivity is reduced in right and left TLE compared to controls, with their distributions and extent differing in right and left TLE subgroups. Quantification of these differences is possible through graph theoretical measurements, and provides a direction for better understanding of TLE dysfunction and possibly lateralization of TLE. Disclosure: Dr. Chiang has nothing to disclose. Dr. Stern has received personal compensation for activities with UCB Pharma, Lundbeck, Cyberonics, Inc., and GlaxoSmithKline, Inc. Dr. Stern has received personal compensation in an editorial capacity for MedLink Neurology. Dr. Engel has nothing to disclose. Dr. Levin has nothing to disclose. Dr. Haneef has nothing to disclose.
Determinants of Sport Commitment among Junior Tennis Players: Enjoyment as a Mediating Variable

This study examined determinants of junior tennis players’ motivation to continue involvement using the sport commitment model as the theoretical framework (20). Based on the sport enjoyment literature, a version of the original sport commitment model (i.e., all determinants directly predict commitment) and a revised model where enjoyment was a mediator of the relationships between determinants and level of commitment were tested. Tennis players (N = 198; ages 10–18 years) completed self-report questionnaires on the constructs of interest. Hypothesized relationships among variables were tested using structural equation modeling. Results provided support for both the original and mediational models, with enjoyment exerting the strongest effect on tennis commitment in both models. An alternative model was tested where both direct and indirect effects through enjoyment on commitment were specified. The alternative model was accepted as most theoretically appealing because determinants of commitment and sourc.