Miracle-dz/UniFAR-FTUs huggingface dataset:
Seasonality of Consumption of Nonstaple Nutritious Foods among Young Children from Nepal's 3 Agroecological Zones

Abstract Background Children's dietary patterns vary seasonally, particularly in subsistence agriculture settings like Nepal, but the seasonality of nutritious nonstaple food consumption is not well explored in the literature. Objective This study aimed to examine seasonal differences in children's consumption of provitamin A–rich fruit and vegetables, dairy, eggs, meat, and fish in Nepal's 3 agroecological zones, and to assess whether seasonal patterns vary by wealth and caste/ethnicity. Methods Multivariable negative binomial regression models were used to analyze dietary data from 7-d food-frequency questionnaires, producing coefficient estimates in the form of incidence rate ratios (IRRs). Data were collected 3 times per year for 2 y from children aged 6–72 mo in Nepal's mountains (n = 226), hills (n = 168), and plains (n = 225). Results There were significant seasonal differences in children's consumption of provitamin A–rich fruit and vegetables, dairy, meat, and fish that varied by agroecological zone. Adopting monsoon season as the referent for all comparisons, children in the mountains ate provitamin A–rich fruit and vegetables less frequently during the postmonsoon and winter seasons (IRRs: 0.5 and 0.7, respectively; both P < 0.004), whereas in the plains, children's consumption of these foods was lower only during the postmonsoon season (IRR: 0.2; P < 0.001). Children's dairy intake frequency increased during the winter in the mountains (IRR: 0.7; P < 0.004) and decreased during the winter in the hills (IRR: 1.5; P < 0.001). Only in the plains did children's meat and fish intakes vary seasonally, increasing during the postmonsoon season (IRR: 1.6; P < 0.004). Wealth and caste/ethnicity variability influenced children's consumption of each of these nutritious groups of foods, and moderated seasonal effects in some instances. Conclusions Children's diets varied differently by season within each agroecological zone of Nepal and in some cases across socioeconomic groups, revealing the importance of taking a season- and location-specific approach to assessing diets and tailoring dietary strategies.
Analysis of Genome-Wide Differentiation between Native and Introduced Populations of the Cupped Oysters Crassostrea gigas and Crassostrea angulata

The Pacific cupped oyster is genetically subdivided into two sister taxa, Crassostrea gigas and C. angulata, which are in contact in the north-western Pacific. The nature and origin of their genetic and taxonomic differentiation remains controversial due the lack of known reproductive barriers and morphologic similarity. In particular, whether ecological and/or intrinsic isolating mechanisms participate to species divergence remains unknown. The recent co-introduction of both taxa into Europe offers a unique opportunity to test how genetic differentiation maintains under new environmental and demographic conditions. We generated a pseudo-chromosome assembly of the Pacific oyster genome using a combination of BAC-end sequencing and scaffold anchoring to a new high-density linkage map. We characterized genome-wide differentiation between C. angulata and C. gigas in both their native and introduced ranges, and showed that gene flow between species has been facilitated by their recent co-introductions in Europe. Nevertheless, patterns of genomic divergence between species remain highly similar in Asia and Europe, suggesting that the environmental transition caused by the co-introduction of the two species did not affect the genomic architecture of their partial reproductive isolation. Increased genetic differentiation was preferentially found in regions of low recombination. Using historical demographic inference, we show that the heterogeneity of differentiation across the genome is well explained by a scenario whereby recent gene flow has eroded past differentiation at different rates across the genome after a period of geographical isolation. Our results thus support the view that low-recombining regions help in maintaining intrinsic genetic differences between the two species.
Socioeconomic Inequalities in Stomach Cancer Screening in Korea, 2005–2015: After the Introduction of the National Cancer Screening Program

Purpose This study aimed to investigate socioeconomic inequalities in stomach cancer screening in Korea and trends therein across income and education groups. Materials and Methods Data from the Korean National Cancer Screening Survey, a nationwide cross-sectional survey, were utilized. A total of 28913 men and women aged 40 to 74 years were included for analysis. Prior experience with stomach cancer screening was defined as having undergone either an endoscopy or gastrointestinal series within the past two years. The slope index of inequality (SII) and relative index of inequality (RII) were evaluated to check inequalities. Results Stomach cancer screening rates increased from 40.0% in 2005 to 74.8% in 2015, with an annual percent change of 5.8% [95% confidence interval (CI) 4.2 to 7.5]. Increases in stomach cancer screening rates were observed for all age, education, and household income groups. Inequalities in stomach cancer screening were noted among individuals of differing levels of education, with a pooled SII estimate of 6.14% (95% CI, 3.94 to 8.34) and RII of 1.26 (95% CI, 1.12 to 1.40). Also, income-related inequalities were observed with an SII of 6.93% (95% CI, 4.89 to 8.97) and RII of 1.30 (95% CI, 1.17 to 1.43). The magnitude of inequality was larger for income than for education. Conclusion Both education and income-related inequalities were found in stomach cancer screening, despite a continuous increase in screening rate over the study period. Income-related inequality was greater than education-related inequality, and this was more apparent in women than in men.
Rituximab, bendamustine and cytarabine (R‐BAC) in patients with relapsed‐refractory aggressive B‐cell lymphoma

and bone marrow mast cell burden (Table 1). Next, we focused on SM-AHN-myeloid (n = 178), which included 11 (6%) patients with SM associated with acute myeloid leukemia (SM-AML), 50 (28%) patients with SM associated with myeloproliferative neoplasms (SM-MPN), 24 (13%) patients with SM associated with myelodysplastic syndromes (SM-MDS), 39 (22%) patients with SM associated with chronic myelomonocytic leukemia (SM-CMML) and 54 (30%) patients with SM associated with MDS/MPN/unclassified (SM-MDS/MPN/Unclassified). Figure 1C confirms the survival superiority of SM-AHN-lymphoid, compared to any other specific category of SM-AHN-myeloid. Prognostic comparison in SM-AHN-myeloid (Figure 1C) is confounded by significant variation in age and risk distribution of the specific myeloid components but appears to favor SMMPN and SM-MDS over other subcategories, including SM-CMML and SM-MDS/MPN/Unclassified (Figure 1C). We conclude that patients with SM-AHN-lymphoid are phenotypically and prognostically different than those with SM-AHN-myeloid and should be cited as such in both clinical practice and future survival studies in SM. Similarly, prognosis in SM-AHN-myeloid appears to be dictated by the specific AHN component, which underscores the need to be more specific in diagnostic assignment and treatment directions. This is particularly important since sensitivity to drug therapy or to other treatment modalities in SM might be different for neoplastic mast cells vs the associated myeloid neoplasm clone.
Interactions Elicited by the Contradiction Between Figure Direction Discrimination and Figure-Ground Segregation

Figure-ground (FG) segregation that separates an object from the rest of the image is a fundamental problem in vision science. A majority of neurons in monkey V2 showed the selectivity to border ownership (BO) that indicates which side of a contour owns the border. Although BO could be a precursor of FG segregation, the contribution of BO to FG segregation has not been clarified. Because FG segregation is the perception of the global region that belongs to an object, whereas BO determination provides the local direction of figure (DOF) along a contour, a spatial integration of BO might be expected for the generation of FG. To understand the mechanisms underlying the perception of figural regions, we investigated the interaction between the local BO determination and the global FG segregation through the quantitative analysis of the visual perception and the spatiotemporal characteristics of eye movements. We generated a set of novel stimuli in which translucency induces local DOF along the contour and global FG independently so that DOF and FG could be either consistent or contradictory. The perceptual responses showed better performance in DOF discrimination than FG segregation, supporting distinct mechanisms for the DOF discrimination and the FG segregation. We examined whether the contradiction between DOF and FG modulates the eye movement while participants judged DOF and FG. The duration of the first eye fixation was modulated by the contradiction during FG segregation but not DOF discrimination, suggesting a sequential processing from the BO determination to the FG segregation. These results of human perception and eye fixation provide important clues for understanding the visual processing for FG segregation.
Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women

Introduction Complement factors mediate the recruitment and activation of immune cells and are associated with metabolic changes during pregnancy. The aim of this study was to determine whether complement factors in the maternal serum and follicular fluid (FF) are associated with in vitro fertilization (IVF) outcomes in overweight/obese women. Methods Forty overweight/obese (BMI = 30.8 ± 5.2 kg/m2) female patients, 33.6 ± 6.3 years old, undergoing IVF treatment for unexplained infertility were recruited. Baseline demographic information, including biochemical hormonal, metabolic, and inflammatory markers, and pregnancy outcome, was collected. Levels of 14 complement markers (C2, C4b, C5, C5a, C9, adipsin, mannose-binding lectin, C1q, C3, C3b/iC3b, C4, factor B, factor H, and properdin) were assessed in the serum and FF and compared to IVF outcome, inflammatory, and metabolic markers using multivariate and univariate models. Results Out of 40 IVF cycles, 14 (35%) resulted in pregnancy. Compared to women with failed pregnancies, women with successful pregnancies had higher levels of adipsin in the serum and FF (p = 0.01) but lower C5a levels (p = 0.05). Serum adipsin levels were positively correlated with circulating levels of vitamin D (R = 0.5, p = 0.02), glucagon (R = 0.4, p = 0.03), leptin (R = 0.4, p = 0.01), resistin (R = 0.4, p = 0.02), and visfatin (R = 0.4, p = 0.02), but negatively correlated with total protein (R = −0.5, p = 0.03). Higher numbers of top-quality embryos were associated with increased levels of C3, properdin, C1q, factors H and B, C4, and adipsin, but with reduced C2 and C5a levels (p ≤ 0.01). Conclusions Higher adipsin and lower C5a levels in the maternal serum during implantation are potential markers of successful outcome in obese women undergoing IVF-assisted pregnancies.
OsCER1 Plays a Pivotal Role in Very-Long-Chain Alkane Biosynthesis and Affects Plastid Development and Programmed Cell Death of Tapetum in Rice (Oryza sativa L.)

Cuticle waxes, which are primarily comprised of very-long-chain (VLC) alkanes, play an important role in plant reproductive development. ECERIFERUM1 (CER1) is recognized as the core element for VLC alkane biosynthesis in Arabidopsis (Arabidopsis thaliana). However, genes involved in the VLC alkane biosynthesis in rice remain unclear, and the alkane-form pathway in rice has still to be further explored. Here, we show that OsCER1, a homology of CER1, functions in VLC alkanes biosynthesis, which also could regulate anther development and plastids differentiation in rice. OsCER1 was highly expressed in the tapetum (stage 10) and bicellular pollen cells (stage 11). The decreased content of VLC alkanes (C25 and C27) in the OsCER1 knocked down plants as well as the increased content of C27 alkanes in the OsCER1 overexpression plants indicates that OsCER1 participates in VLC alkane biosynthesis. Downregulation of OsCER1 in rice led to sterility, and fewer amyloplasts within the mature pollen grains. In addition, the downregulation of OsCER1 in rice caused delayed tapetal programmed cell death and abnormal development of plastids in the tapetal cells. Furthermore, significantly altered levels of expression of genes involved in the pollen development were exhibited in the OsCER1 knocked down plants. These results indicate that OsCER1 is critical for VLC alkanes biosynthesis, plastids differentiation, and pollen development. This work provides insights into the VLC alkanes biosynthesis in anther development in rice.
The Vulvar Vernacular: Dilemmas Experienced and Strategies Recommended by Women with Chronic Genital Pain

ABSTRACT This manuscript uses Goldsmith’s (2004) normative model of social support to explore conversations women have with a romantic partner about vulvodynia. Twenty-six women with vulvodynia participated in semi-structured interviews in which they described conversational goals, discussed challenges, and offered advice to others managing vulvodynia. As this study was concerned with interactions with romantic partners both present and past, women with vulvodynia, not their partners, were the targets of recruiting efforts. Two key communicative dilemmas emerged from the data analysis: (a) I need to talk to you, but I can’t, and (b) I want to be honest, but not too honest. These dilemmas represent ambiguity about the causes and duration of pain and the implications that being unable to have pain-free intercourse has for their relationships and identities as women. Three strategies, communicative practices for managing dilemmas, also emerged: (a) reframe the illness, (b) refocus the relationship, and (c) redefine intimacy. The theoretical and practical implications of this research are socially situated within timely conversation about women, their bodies, and their roles.
Monocytes accumulate in the airways of children with fatal asthma

Activated T helper type 2 (Th2) cells are believed to play a pivotal role in allergic airway inflammation, but which cells attract and activate Th2 cells locally have not been fully determined. Recently, it was shown in an experimental human model of allergic rhinitis (AR) that activated monocytes rapidly accumulate in the nasal mucosa after local allergen challenge, where they promote recruitment of Th2 cells and eosinophils.
Effect of the board game as educational technology on schoolchildren’s knowledge on breastfeeding 1

ABSTRACT Objective: to evaluate the effect of the board game as an educational technology on schoolchildren’s knowledge on breastfeeding. Method: cluster-randomized clinical trial, held in nine schools, with 99 children in the third grade of elementary school (control group = 51 and intervention group = 48). The pretest was conducted in both groups; intervention consisted in the application of the educational technology immediately after pretest to the intervention group; and the post-test was applied on the 7th and 30th days to both groups. For the analysis of children’s knowledge on breastfeeding, we considered the pre- and post-test score means, using the Mann-Whitney test - for comparing the means between groups - and the Wilcoxon test - within the same group. Results: there was no statistically significant difference between the groups in the pretest. In the follow-up, when comparing the groups, there were higher means in the intervention group, on the 7th (19.68 ±1.788) and on the 30th (20.16±1.260) days, with statistically significant difference. Within the intervention group, there was significant increase of the means in the pretest (15.89±3.082) for the 30th day (20.16±1.260). Conclusion: such educational intervention has significantly contributed to the increase in scores of children’s knowledge on breastfeeding for the intervention group. UTN: U1111-1184-7386.
Knowledge Integrated Classifier Design Based on Utility Optimization

This paper proposes a systematic framework to design a classification model that yields a classifier which optimizes a utility function based on prior knowledge. Specifically, as the data size grows, we prove that the produced classifier asymptotically converges to the optimal classifier, an extended version of the Bayes rule, which maximizes the utility function. Therefore, we provide a meaningful theoretical interpretation for modeling with the knowledge incorporated. Our knowledge incorporation method allows domain experts to guide the classifier towards correctly classifying data that they think to be more significant.
Shallow Water Depth Retrieval From Multitemporal Sentinel-1 SAR Data

The Sentinel-1 constellation can provide numerous high-resolution C-band synthetic aperture radar (SAR) data with long-term continuity and freely, thus showing a cost-effective solution for the coastal monitoring at high or moderate spatial resolutions. The major goal is to improve estimates of shallow water depth for SAR applications. We present an algorithm that is based on the linear dispersion relation between water depth and swell parameters like swell wavelength, direction, and period to estimate shallow water depth using multitemporal SAR data with a short repeating cycle. This is accomplished via circular convolution and Kalman filter that provides both the estimates and a measure of their uncertainty at each location. The introduced algorithm is tested on four Sentinel-1 interferometric wide swath (IW) mode SAR images over the coastal region of Fujian Province, China. The retrieved water depth both from multitemporal SAR images and different single SAR images show general agreement with water depth from an official electronic navigational chart. All comparisons indicate that the proposed method is feasible and multitemporal SAR data have great potential in bathymetric surveying.
Appendiceal Neoplasms

Abstract Appendiceal neoplasms are identified in 0.9 to 1.4% of appendiceal specimens, and the incidence is increasing. It has long been professed that neuroendocrine tumors (formerly carcinoids) are the most common neoplastic process of the appendix; recent data, however, has suggested a shift in epidemiology. Our intent is to distill the complex into an algorithm, and, in doing so, enable the surgeon to seamlessly maneuver through operative decisions, treatment strategies, and patient counseling. The algorithm for evaluation and treatment is complex, often starts from the nonspecific presenting complaint of appendicitis, and relies heavily on often subtle histopathologic differences.
IRTED-TL: An Inter-Region Tax Evasion Detection Method Based on Transfer Learning

Tax evasion detection plays a crucial role in addressing tax revenue loss. Many efforts have been made to develop tax evasion detection models by leveraging machine learning techniques, but they have not constructed a uniform model for different geographical regions because an ample supply of training examples is a fundamental prerequisite for an effective detection model. When sufficient tax data are not readily available, the development of a representative detection model is more difficult due to unequal feature distributions in different regions. Existing methods face a challenge in explaining and tracing derived results. To overcome these challenges, we propose an Inter-Region Tax Evasion Detection method based on Transfer Learning (IRTED-TL), which is optimized to simultaneously augment training data and induce interpretability into the detection model. We exploit evasion-related knowledge in one region and leverage transfer learning techniques to reinforce the tax evasion detection tasks of other regions in which training examples are lacking. We provide a unified framework that takes advantage of auxiliary data using a transfer learning mechanism and builds an interpretable classifier for inter-region tax evasion detection. Experimental tests based on real-world tax data demonstrate that the IRTED-TL can detect tax evaders with higher accuracy and better interpretability than existing methods.
Learning Concept Abstractness Using Weak Supervision

We introduce a weakly supervised approach for inferring the property of abstractness of words and expressions in the complete absence of labeled data. Exploiting only minimal linguistic clues and the contextual usage of a concept as manifested in textual data, we train sufficiently powerful classifiers, obtaining high correlation with human labels. The results imply the applicability of this approach to additional properties of concepts, additional languages, and resource-scarce scenarios.
Effect of Blending Soy Milk with Cow Milk on some Properties of Bio-Labneh

Labneh (concentrated yoghurt) is a semisolid dairy product made from yoghurt by draining away part of its water. The effect of utilization soy milk and ABT culture in Labneh preparation on chemical composition, microbial properties and sensory evaluationproperties was studied. Six treatments of Labneh were manufactured from soy and cow milk and their mixtures using classic and ABT-5 starters. Values of yield, acidity, redox potential (Eh), total solids (TS), fat, ash, TN, TVFA, saturated fatty acids (SFA), monounsaturated fatty acids (MUSFA), and total amino acids were lower while unsaturated fatty acids (USFA), polyunsaturated fatty acids (PUSFA) and linoleic acid and α-linolenic acid contents were higher in Labneh made from soy milk than that made from cow milk. Also, Str.thermophillus, L. acidophilus and bifido bacteria numbers were high in soy milk Labneh. Mixing of cow milk with soy milk improved the sensory evaluation scores of Labneh. Labneh made using classic starter had higher values of yield, acidity, WSN, TVFA, SFA and lower values of pH than that made using of ABT Labneh. ABT culture Labneh possessed high levels of USFA and total free amino acids contents.
Obesity in the global haemophilia population: prevalence, implications and expert opinions for weight management

Overweight and obesity may carry a significant disease burden for patients with haemophilia (PWH), who experience reduced mobility due to joint inflammation, muscle dysfunction and haemophilic arthropathy. This review aimed to define the prevalence and clinical impact of overweight/obesity in the global population of PWH. A detailed literature search pertaining to overweight/obesity in haemophilia in the last 15 years (2003–2018) was conducted, followed by a meta‐analysis of epidemiological data. The estimated pooled prevalence of overweight/obesity in European and North American PWH was 31%. Excess weight in PWH is associated with a decreased range in motion of joints, accelerated loss of joint mobility and increase in chronic pain. Additionally, the cumulative disease burden of obesity and haemophilia may impact the requirement for joint surgery, occurrence of perioperative complications and the prevalence of anxiety and depression that associates with chronic illness. Best practice guidelines for obesity prevention and weight management, based on multidisciplinary expert perspectives, are considered for adult and paediatric PWH. Recommendations in the haemophilia context emphasize the importance of patient education and tailoring engagement in physical activity to avoid the risk of traumatic bleeding.