Miracle-dz/UniFAR-FTUs huggingface dataset:
IS Continuance in Experiential Computing Contexts: Linking Rational and Non-rational Behaviors through Technology Associability

The IS literature currently explains continuous-use of IT as a post-adoptive behavior driven by rational cognitive beliefs or non-rational affective/automatic responses. Yet the use contexts, IT artifact characteristics, and the notion of the IT user, underlying the current thinking have evolved. We are in a so-called experiential computing paradigm where computing capabilities have become so deeply embedded in everyday life experiences that IT artifacts have become an extension of the human self, closely tied to the personal behaviors and preferences of users. In this empirical context, new continuance behaviors are emerging for which the current literature falls short in explanation. We have just begun a program of study to address this issue. In the summer paper reported here, we build on previous work in IS and draw from theories of selfidentity and stereotypes in social psychology to introduce the concept of IT Associability, and argue that it plays a central role in explaining and predicting continuous-use in experiential computing contexts. Our concept of IT associability taps the social and relational characteristics of an IT to theorize how user attachment to an IT they currently use may significantly influence their decisions concerning future versions of the IT. We attempt, through this perspective, to bridge the gap between rational and non-rational theories by offering a novel yet complementary lens for exploring other processes shaping continuous-use of everyday IT artifacts. We present preliminary validated items for measuring IT associability. Some implications for managing the blurring lines between organizational and personal IT use at the workplace are also discussed.
On the value of using an interactive electronic textbook in an introductory programming course

E-books including interactive elements are rapidly becoming more popular and are likely to largely replace traditional textbooks at university level education. In this paper, we report our initial observations on the changes we noticed in students' motivational factors and learning results when a static PDF textbook was replaced by an interactive e-textbook in a large CS1 service course. We found increase in both motivational factors, as well as learning gain. In addition, students' feedback on the learning resources improved. While the changes were not large, they encourage to continue integrating more interactive learning content into course learning environment.
Failure of periconceptual folic acid to prevent a neural tube defect in the offspring of a mother taking sodium valproate

, it has been suggested that women on VPAshould take a similar high-dose periconceptually. Wereport the case of a woman exposed to VPA who gavebirthtoaninfantwithanNTD,amongothermalforma-tions, despite taking high-dose folic acid periconceptu-ally and emphasize there is no evidence that folic acidin any dose protects against NTDs caused by VPA.Case ReportA baby boy was delivered to a 26 year old womanfollowing a planned pregnancy. The child had a lum-bosacral NTD, small ventricular and atrial septal de-fects, a cleft of the soft palate, bilateral talipes and fea-tures consistent with foetal valproate syndrome. Chro-mosomal analysis demonstrated a normal male kary-otype. The NTD and cleft palate were subsequentlyrepaired.The mother, who was otherwise well, had presentedaged 16 years with a 2 year history of prolonged ab-senceseizuresandanEEGshowingfeaturesinkeepingwith primary generalized epilepsy. She was prescribedVPA500mgBD(twicedaily)andbecameseizurefree.Four years later the seizures returned and the dose ofVPA was increased to 1000 mgs twice daily. The mar-ried woman, who at the age of 23 had been seizurefree for 4 years, was prescribed 4mg/day folic acid.She remained seizure free and 18 months later becamepregnant. She stopped the folic acid at the end of theﬁrst trimester. There was no family history of birthabnormalities. Foetal ultrasound during the pregnancyhad raised no concerns.DiscussionSodium valproate was the probable cause of the mal-formations, as all have been described with this drug
Patients’ Needs and Experiences at Breast Cancer Diagnosis: How Perceived Threat Influences the Physician–Patient Interaction

Physician–patient interaction at breast cancer diagnosis can only succeed if physicians know what patients want. To investigate patients’ needs and experiences we conducted semistructured interviews with eight patients. Verbatim transcripts were analyzed according to grounded theory and a typological approach. Patients’ needs and experiences concurred with a patient-centered approach in many aspects. The threat perceived by patients following diagnosis strongly influenced their needs and experiences. Three different types of patients were identified: emotionally needy, active, and trustful, adaptive. The typology identified in this study may help physicians to adequately adapt their behavior.
Bulky disease is the most important prognostic factor in Hodgkin lymphoma stage IIB

Abstract: The aim of this study was to evaluate treatment results for Hodgkin lymphoma (HL) patients younger than 60 yr in stage IIB, treated according to the Swedish National Care Programme. The intention was also to identify specific subgroups depending on the number of negative prognostic factors the patients have, in order to optimise and differentiate future treatment. In total, 99 patients with HL stage IIB, diagnosed between 1985 and 1994, have been analysed. There were 47 men and 52 women and the median age was 33 yr (range 17–59). Eighty‐six patients presented with supradiaphragmatic disease and 13 with infradiaphragmatic. The HL specific and overall 10‐yr survival was 73 and 65%, respectively. The HL‐specific survival for patients in pathological stage IIB tended to be better, although not statistically significant than for clinical stage IIB, despite less chemotherapy (P = 0.1). The patients in stage IIB who were selected for laparotomy were, however, younger and with fewer negative prognostic factors. The only significant negative prognostic factor was bulky disease (P = 0.001). The following factors also tended to have a negative influence on the prognosis although not statistically significant: the International Prognostic Score, the number of involved lymph node stations, extranodal involvement and leucocyte count >15 × 109/L. In conclusion, we suggest that bulky disease should be taken into account when treating patients with stage IIB HL.
The motivations for citizens' adoption of e-government: an empirical study in the UAE

The aim of this study is to identify the factors that encourage citizens to adopt e-government in the United Arab Emirates (UAE), specifically in Dubai. The UAE is considered one of the leading countries offering this service in the Arab world. Dubai, which is one of the emirates in the UAE, formally launched this service in 2001. Drawing on the technology acceptance model (TAM), this paper develops a framework incorporating the following exogenous factors: quality of internet connection, computer self-efficacy, security issues and website features. The proposed modified TAM model has been tested with a survey sample of 502 which was distributed among citizens in Dubai. The data have been analysed using structured equation modelling (SEM) to evaluate the strength of the hypothesised relationships. The results strongly support the extended TAM model in predicating citizens' attitude towards e-government. They also demonstrate the significant effect of exogenous factors on citizens' attitude through perceived ease of use and perceived usefulness. The implications of the findings of this study are discussed and suggestions for future research are presented.
The Impact of Mental Health and Substance Abuse Factors on HIV Prevention and Treatment

The convergence of HIV, substance abuse (SA), and mental illness (MI) represents a distinctive challenge to health care providers, policy makers, and researchers. Previous research with the mentally ill and substance-abusing populations has demonstrated high rates of psychiatric and general medical comorbidity. Additionally, persons living with HIV/AIDS have dramatically elevated rates of MI and other physical comorbidities. This pattern of co-occurring conditions has been described as a syndemic. Syndemic health problems occur when linked health problems involving 2 or more afflictions interact synergistically and contribute to the excess burden of disease in a population. Evidence for syndemics arises when health-related problems cluster by person, place, or time. This article describes a research agenda for beginning to understand the complex relations among MI, SA, and HIV and outlines a research agenda for the Social and Behavioral Science Research Network in these areas.
Tetrel-bonding interaction: rediscovered supramolecular force?

The w(hole) picture: A tetrel bond is a directional noncovalent interaction between a covalently bonded atom of Group IV and a negative site, for example, the lone pair of a Lewis base or an anion. It involves a region of positive electrostatic potential (σ hole), and energetically, they are comparable to hydrogen bonds and other σ-hole-based interactions.
An Approach to the Management of Pleural Empyema with Early Video-assisted Thoracoscopic Surgery and Early Transition to Oral Antibiotic Therapy

Practice variation exists in the management of children with bacterial pneumonia complicated by empyema. The success of video-assisted thoracoscopic surgery (VATS) versus chest tube insertion for drainage and fibrinolysis may be dependent on the stage of disease. There is little published experience with early transition to oral (PO) antibiotics, and many children are treated with intravenous (IV) antibiotics at home. To describe a cohort of children with pneumonia and empyema in a primarily rural state managed with early VATS and transition to PO antibiotics. This was a retrospective medical record review of children managed by the pediatric infectious diseases and surgery services at Kosair Children's Hospital from 2008 through 2012. Sixty-one children met inclusion criteria. The majority underwent VATS on the first or second hospital day. No organism was identified in 67 per cent of cases. All patients received IVantibiotics at admission and all were discharged on PO antibiotics. The median time to transition was five days (interquartile range [IQR], 4–6), and the median duration of PO therapy was 16 days (IQR, 14–21). Ninety-eight per cent did not require further IV therapy. There were no deaths and clinical outcomes were good. In conclusion, children with pneumonia and empyema can be managed effectively with early VATS and early transition from IV to PO antibiotic therapy.
Characterization of the Dihydropyridine Binding Sites of Rat Neocortical Synaptosomes and Microvessels

Abstract: The dihydropyridine binding sites associated with rat neocortical synaptosomes and microvessels were compared using an in vitro [3H]PN 200–110 [(+)‐[methyl‐3H]‐isopropyl 4‐(2,1,3‐benzoxadiazol‐4‐yl)‐1,4‐dihydro‐2,6‐di‐methyl‐5‐methoxycarbonylpyridine‐3‐carboxylate] binding assay. Saturation experiments yielded similar KD values (∼70 pM) and Bmax values (∼400 fmol/mg of protein) for the two membrane preparations. Interaction experiments with [3H]PN 200–110 and various calcium‐modulating substances provided further evidence for the practically identical nature of the synaptosomal and microvascular dihydropyridine binding sites. These findings predict that lipophilic dihydropyridines, simultaneously occupying the two central binding sites, have the dual effect of altering neuronal function and local blood flow.
The usefulness of Tc-99m tetrofosmin scintigraphy in the diagnosis and localization of hyperfunctioning parathyroid glands.

PURPOSE The aim of the work was to study the diagnostic value of Tc-99m tetrofosmin to localize anomalous parathyroid glands in patients with hyperparathyroid disease. METHODS We studied 31 patients, 19 with primary and 12 with secondary hyperparathyroid disease. Five of these patients were renal graft recipients. All patients underwent surgery. Each patient was injected with 555 to 740 MBq (15 to 20 mCi) Tc-99m tetrofosmin. Subsequently, radionuclide images were acquired 15 and 120 minutes after injection using a low-energy, all-purpose, parallel-hole collimator. Pertechnetate thyroid scintigraphy was obtained in nine cases (24 to 48 h later) when the thyroid activity made it difficult to identify the parathyroid glands. RESULTS All cases showed tracer uptake as early as 15 minutes after injection. In the group of patients with primary hyperparathyroid disease, 15 showed focal uptake in a parathyroid gland, and surgery revealed an adenoma in the same location. In one patient with hyperplasia, scintigraphy identified only two of four diseased glands. In the three remaining cases, scintigraphy showed focal uptake in the lower parathyroid gland, whereas at surgery the abnormal gland was located in the upper pole. In the secondary hyperparathyroidism group, seven patients showed diffuse tracer uptake in two or more glands, and histologic analysis confirmed hyperplasia in all of them. Five cases showed focal uptake, with three evaluated after surgery (uptake in the only remaining gland); one of them was a renal graft recipient, and the remaining patient had chronic renal failure and was receiving hemodialysis. CONCLUSIONS Our results suggest that Tc-99m tetrofosmin may be a suitable tracer for preoperative detection and screening of anomalous parathyroid glands. The earlier images at 15 minutes were better than those at 120 minutes. Tc-99m tetrofosmin is cleared more slowly from the normal thyroid than is Tc-99m sestamibi, and both of these tracers may give better results than the old pertechnetate TI-201 subtraction technique.
Lamotrigine in idiopathic epilepsy – increased risk of cardiac death?

Objectives – Lamotrigine (LTG) has recently been shown to inhibit the cardiac rapid delayed rectifier potassium ion current (Ikr). Ikr‐blocking drugs may increase the risk of cardiac arrhythmia and sudden unexpected death. With this background, it may be of importance that in our outpatient clinic between August 1, 1995 and August 1, 2005 we registered four consecutive cases of sudden unexpected death in epilepsy (SUDEP) in non‐hospitalized patients that were all being treated with LTG in monotherapy. Here we describe and discuss these cases, the relevant literature, and the reasons to question whether these events were as a result of coincidence alone.
High intensity focused ultrasound as a potential new modality for the treatment of pigmentary skin disorder

The clinical skin tightening benefits of high intensity focused ultrasound (HIFU) have been established, but its mechanism of action in pigmented skin disorders remains unknown. We macroscopically and histopathologically investigated dermatological changes after HIFU at different exposure doses in a UVB‐induced guinea pig model of hyperpigmentation.
Statin therapy at carotid angioplasty and stent placement: effect on procedure-related stroke, myocardial infarction, and death.

PURPOSE To retrospectively determine if preprocedural statin treatment is associated with a reduction of cardiovascular events after carotid angioplasty and stent placement (CAS) in patients with symptomatic carotid stenosis. MATERIALS AND METHODS A study resulting in a prospective database was approved by the institutional ethics review board; written informed consent was obtained. The approval and informed consent included future retrospective analysis. Consecutive patients (n = 180) from the prospective database underwent CAS for high-grade symptomatic carotid disease. The frequency of cardiovascular complications (composite of stroke, myocardial infarction, and death within 30 days after CAS) between 127 patients without preprocedural statin treatment and that of 53 patients with preprocedural statin treatment at CAS were compared with chi2 and multivariate logistic regression analysis. RESULTS The overall 30-day myocardial infarction rate was two of 180 (1%) patients, the minor stroke rate was 16 of 180 (9%) patients, the major stroke rate was one of 180 (0.5%) patients, and the death rate was two of 180 (1%) patients. The incidence of cardiovascular events (composite of stroke, myocardial infarction, and death within 30 days after CAS) was significantly different between patients with preprocedural treatment (4%) and those without preprocedural statin treatment (15%) (P < .05). These higher complication rates among patients without preprocedural statin treatment were not mediated by adjustment for age, sex, other baseline characteristics, degree of carotid stenosis, use of cerebral protection devices, or the year in which CAS was performed. CONCLUSION Preprocedural statin therapy appears to reduce the incidence of stroke, myocardial infarction, and death within 30 days after CAS. Future prospective randomized trials are warranted to further assess this potential protective effect of statin drugs during carotid interventions.
QUANTITATIVE CONVERSION OF CELLS AND PROTOPLASTS OF PROTEUS MIRABILIS AND ESCHERICHIA COLI TO THE L-FORM

In the past few years considerable interest in the bforms of bacteria has developed, and numerous descriptive papers have been published on their morphology, cytology, occurrence, and cultivation. These are well summarized in several reviews (Dienes and Weinberger, 1951; Tulasne, 1953; Minck, 1955; Sincovics, 1956). A thoroughgoing chemical and enzymatic study of Proteus b-forms has also been published recently (Kandler et al., 1956b, c). In the extensive list of publications cited in these papers, the quantitative control of formation and growth of I-forms has received relatively little attention. The present study of b-forms was initiated in order to gain a better understanding of the genetic or phenotypic changes associated with the various morphological changes of the b-cycle. Since many phases of such a study require enumeration and quantitative recovery of organisms, clarification of some of the unsolved methodological problems in b-form experimentation is required. In this paper, attention is focused on the first step of the Ibcycle-the change from bacillary form to large body to bcolony. Several authors have indicated the portion of viable cells which give rise to bcolonies. Tulasne (1953) stated that only 1 per 105 organisms produced Lcolonies in his system, while Medill and O'Kane (1954) reported that 1 per cent of the cells of a Proteus culture will form b-colonies. According to Dienes and Weinberger (1951), only 5 per cent of the large bodies of Proteus formed under the influence of penicillin are "viable. "' These results leave open the question whether the ability to produce an bcolony is confined to certain variant cells in a population, or whether all cells are capable of giving rise to L-colonies under appropriate growth conditions.
Transepithelial Neutrophil Migration Is CXCR1 Dependent In Vitro and Is Defective in IL-8 Receptor Knockout Mice1

Neutrophil migration across infected mucosal surfaces is chemokine dependent, but the role of chemokine receptors has not been investigated. In this study, chemokine receptors were shown to be expressed by epithelial cells lining the urinary tract, and to play an essential role for neutrophil migration across the mucosal barrier. Uroepithelial CXCR1 and CXCR2 expression was detected in human urinary tract biopsies, and in vitro infection of human uroepithelial cell lines caused a dramatic increase in both receptors. As a consequence, there was higher binding of IL-8 to the cells and the IL-8-dependent neutrophil migration across the infected epithelial cell layers was enhanced. Abs to IL-8 or to the CXCR1 receptor inhibited this increase by 60% (p < 0.004), but anti-CXCR2 Abs had no effect, suggesting that CXCR1 was the more essential receptor in this process. Similar observations were made in the mouse urinary tract, where experimental infection stimulated epithelial expression of the murine IL-8 receptor, followed by a rapid flux of neutrophils into the lumen. IL-8 receptor knockout mice, in contrast, failed to express the receptor, their neutrophils were unable to cross the epithelial barrier, and accumulated in massive numbers in the tissues. These results demonstrate that epithelial cells express CXC receptors and that infection increases receptor expression. Furthermore, we show that CXCR1 is required for neutrophil migration across infected epithelial cell layers in vitro, and that the murine IL-8 receptor is needed for neutrophils to cross the infected mucosa of the urinary tract in vivo.
Title Constitutive activation of NF-κ B in human hepatocellularcarcinoma : Evidence of a cytoprotective role Author ( s )

Activation of nuclear factorB (NFB) can promote or inhibit apoptosis. Oxidative stress is an important mechanism by which certain anticancer drugs kill cancer cells, and is also one of the mechanisms that activate NFB. We therefore examined hepatic expression of the NFB monomer p65 in human hepatocellular carcinoma (HCC) tissue samples from eight patients and compared it with their respective samples of surrounding liver tissues. We also studied the effect of NFB inhibition in human HCC cells exposed to oxidative stress, by infecting HuH7 cells with a recombinant adenovirus carrying mutant I B (mI B ). Cultured HuH7 cells were infected with mI B or -galactosidase ( -Gal) for 24 hr followed by treatment with increasing concentrations of H2O2. Cytotoxicity, NFB translocation, NFB DNA binding, cell proliferation, and apoptosis were determined. The monomer p65 was overexpressed in six of eight human HCC tissues. In HuH7 cells, introduction of mI B potently inhibited the translocation, activation, and DNA binding of NFB. In control ( -Gal-infected) HuH7 cells, exposure to H2O2 produced a dose-dependent increase in apoptosis, regardless of NFB status. mI B -mediated inhibition of NFB activation sensitized HuH7 cells to H2O2-induced inhibition of cell growth, and further promoted cell death. Addition of H2O2 (200–500 M) to control or mI B -infected HuH7 cells enhanced caspase-3 activity and cleavage. Adenovirus-mediated transfer of mI B potently inhibits NFB activity in HuH7 cells, and this enhances oxidative stress-induced cell killing.