Miracle-dz/UniFAR-FTUs huggingface dataset:
SAFETY AND EFFICACY OF EPLERENONE IN PATIENTS AT HIGH RISK FOR HYPERKALEMIA AND/OR WORSENING RENAL FUNCTION. ANALYSES OF THE EMPHASIS-HF STUDY SUBGROUPS (EPLERENONE IN MILD PATIENTS HOSPITALIZATION AND SURVIVAL STUDY IN HEART FAILURE)

Translation articles: R. Eschalier, J.J.V. McMurray, K. Swedberg, D.J. van Veldhuisen, H. Krum, S.J. Pocock, H. Shi, J. Vincent, P. Rossignol, F. Zannad, B. Pitt, for the EMPHASIS-HF Investigators “Safety and Efficacy of Eplerenone in Patients at High Risk for Hyperkalemia and/or Worsening Renal Function. Analyses of the EMPHASIS-HF Study Subgroups (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure)” J Am Coll Cardiol 2013;62(17):1585-93; http://dx.doi. org/10.1016/ j.jacc. 2013.04. 086
The Utility of Sentinel Lymph Node Mapping in High-Grade Endometrial Cancer

Objective The aim of this study was to report the utility and false-negative rates of sentinel lymph node (SLN) mapping during surgical staging of women with high-grade, apparent uterine-confined endometrial cancer. Methods This was a single-institution study performed at a high-volume academic center. From December 2012 to December 2015, women with high-grade endometrial cancer (grade 3 endometrioid, serous, clear cell, and carcinosarcoma) underwent SLN mapping via cervical injection followed by robot-assisted total laparoscopic hysterectomy and completion lymphadenectomy. Ultrastaging of SLNs was performed in patients with tumors with any degree of myoinvasion. Patient demographics, SLN test characteristics, treatment, and recurrence outcomes were prospectively evaluated for analysis. Results Fifty-two patients with high-grade histologic findings underwent SLN mapping followed by completion lymphadenectomy. The median patient age was 64 years, and median body mass index was 31.8 kg/m2. Most patients had either serous (46%) or grade 3 endometrioid histology (27%) on preoperative biopsy. Nine patients had nodal metastases, 7 of whom had metastases identified in SLNs. No low-volume nodal metastases were identified on ultrastaging. Two patients had false-negative SLN mapping (22%). After a median follow-up of 15.6 months, 14 recurrences (27%) were diagnosed; all were distant or multisite relapses. Sentinel lymph node mapping did not impact the choice of adjuvant therapy or recurrence risk in node-positive patients. Conclusions Sentinel lymph node detection of metastases in patients with high-grade endometrial cancer is high, but false-negative results were encountered. More research is needed to determine whether SLN mapping can safely replace systemic lymphadenectomy in women with high-risk histologic findings.
Comparative Cure Rates of Artesunate-Praziquantel Combination and Praziquantel Monotherapy in the Control of Urinary Schistosomiasis among Almajiri School Children in Sokoto, Nigeria

Schistosomiasis is the third most devastating tropi cal disease in the world and about the most important of all water impounding diseases in the t ropics. In the absence of vaccine for preventing th e disease and the widely reported therapeutic failure with praziquantel monotherapy, identification of drug combinations with high therapeutic efficacy is crucial to protecting vulnerable populations such as ‘Almajiri’ children from the scourge of the dise ase.
Automatic detection of facial feature points and contours

This paper presents a method for automatic processing of human faces from color images. We describe a new system, which works hierarchically from detecting the position of human faces and their features (such as eyes, nose, mouth, etc.) and to extracting their contours and feature points. The position of human faces and their parts are detected from the image by applying the integral projection method, which uses both the color information (skin and hair color) and edge information (intensity and sign). A multiple active contour model is used to extract the contour-lines of facial features. To do this, we use color information in their energy terms. Facial feature points are decided based on the optimized contours. A constructed 3D facial model using these points can be used to generate its facial expression or change its view. The proposed system is confirmed to be very effective and robust when dealing with images of faces with complex backgrounds.
Effects of 8-week Static Stretch and PNF Training on the Angle-torque Relationship

This study tested the hypothesis that the extent of enhancement in muscle strength following an 8-week program of static stretch (SS) and proprioceptive neuromuscular facilitation (PNF) training would be related to a shift in optimum angle (OA) toward a longer muscle length. Thirty healthy males were randomly assigned into SS, PNF, and control (CON) groups (n=10 per group). The SS and the PNF groups engaged in flexibility training three times per week for eight weeks, while the CON group underwent no training during this time. Passive range of motion (P-ROM) of the hip and maximal isokinetic concentric strength (ISO) at the angular velocity of 60°/s (i. e, the angle-torque relationship) were measured before and after training for all groups. The results of this study showed that compared to before training, the P-ROM values of both the SS (25°) and PNF (31°) groups were significantly increased (P＜0.05) after training, while those of the CON group remained unchanged (P＞0.05). In addition, after the training, both the SS and PNF groups saw a significant increase in ISO (SS: 13%; PNF: 17%; P ＜0.05), and a marked shift of the OA toward a longer muscle length (SS: 9°; PNF: 10°; P＜0.05). The CON group, however, saw no significant change in either of these two variables. There was a positive correlation (P＜0.05) between the increase in ISO and the shift of OA toward a longer muscle length for the SS (r=. 69) and PNF (r=. 78) groups after training. It was concluded that eight weeks of SS and PNF training can not only effectively improve flexibility, but also increase ISO and cause a shift of OA toward a longer muscle length.
A bilevel programming model for autonomous intersection control and trajectory planning

Advances in autonomous and connected vehicles bring new opportunities for intelligent intersection control strategies. In this paper, we propose a centralised way to jointly integrate an intersection control problem with vehicle trajectory planning. It is formulated as a bilevel optimisation problem in which the upper level is designed to minimise the total travel time by a mixed integer linear programming (MILP) model. In contrast, the lower level is a linear programming (LP) model with an objective function to maximise the total speed entering the intersection. The two levels are coupled by the arrival time and terminal speed. By using the relationship between the safe time headway and the process time, a novel platoon-based method is developed to reduce the computational burden. Finally, simulation tests are carried out to investigate the control performance under different demands, intersection lengths, communication ranges and traffic compositions.
Congenital and metabolic disorders leading to fracture

While fractures in children are usually due to trauma only, there are a number of congenital and metabolic conditions which will predispose a child to fractures and lower the threshold of a bone to breaking. These conditions can also influence the pattern of the fracture and the process of bone healing. There are a number of conditions which lead to specific pathological and clinical changes and also several relatively common conditions which must be considered when assessing any child with recurrent fractures. We present a review of congenital and metabolic causes of fractures, focusing largely on the details of osteogenesis imperfecta and congenital pseudoarthrosis of the tibia.
Evidence-Based Guidelines for Resistance Training Volume to Maximize Muscle Hypertrophy

THE MANIPULATION OF RESISTANCE TRAINING (RT) VARIABLES IS WIDELY CONSIDERED AN ESSENTIAL STRATEGY TO MAXIMIZE MUSCULAR ADAPTATIONS. ONE VARIABLE THAT HAS RECEIVED SUBSTANTIAL ATTENTION IN THIS REGARD IS RT VOLUME. THIS ARTICLE PROVIDES EVIDENCE-BASED GUIDELINES AS TO VOLUME WHEN CREATING RT PROGRAMS DESIGNED TO MAXIMIZE MUSCLE HYPERTROPHY.
Experiences of the older person with cancer : a qualitative study of medical and specialist ward settings

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Sonographic gallbladder wall thickness in normal adult population in Nigeria : original article

Aim. The aim of the study was to determine the ultrasonic gallbladder wall thickness in normal adult Nigerians so as to create standards for defining gallbladder abnormalities in Nigerians. Method. Four hundred adults comprising 228 (57%) women and 172 (43%) men aged 16 - 78 years, who had normal clinical history and physical findings, were recruited. The gallbladder wall thickness was obtained in the supine, prone and right anterior oblique positions. Differences in gallbladder wall thickness were determined using the chi-square test, while the relationship between the ultrasound-measured gallbladder wall thickness and the subjects' age, sex, height and weight were analysed using the Pearson product moment correlation. Normal ranges and related statistics were estimated and tabulated according to age group and sex. Results. The mean age of the subjects was 32±13.2 years. The mean gallbladder wall thickness range was 1.8 - 2.8 mm±0.5mm. The thickness range for females was 1.7 - 2.7 mm±0.5 mm, and that for males was 1.9 - 2.9 mm±0.5 mm. There was a statistically significant difference (p<0.05) in the mean wall thickness between males and females. The mean body parameters (height, weight) of males were significantly greater than those of females (p<0.047, p<0.000 respectively). There was no correlation between gallbladder wall thickness and age and height of subjects (r=0.34, p<0.09). Conclusion. Our study was able to establish population-specific ultrasonic values for gallbladder wall thickness in normal adults that can be reliably used as standards to define gallbladder abnormalities in Nigerians.
Biologically Inspired Cognitive Architectures , BICA 2018 ( Ninth Annual Meeting of the BICA Society ) Higher-level Knowledge , Rational and Social Levels Constraints of the Common Model of the Mind

We present the input to the discussion about the computational framework known as Common Model of Cognition (CMC) from the working group dealing with the knowledge/rational/social levels. In particular, we present a list of the higher level constraints that should be addressed within such a general framework. c © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) Peer-review under responsibility of the scientific committee of the 9th Annual International Conference on Biologically Inspired Cognitive Architectures.
Handbook of Drug Interactions: A Clinical and Forensic Guide, 2nd Edition

Part I. Central Nervous System Drugs Chapter 1: Drug Interactions with Benzodiazepines: Epidemiologic Correlates with Other CNS Depressants and In Vitro Correlates with Inhibitors and Inducers of Cytochrome P450 3A4 David E. Moody Chapter 2: Antiepileptic Drugs Nathan L. Kanous II and Barry E. Gidal Chapter 3: Opioids and Opiates Seyed-Adel Moallem, Kia Balali-Mood, and Mahdi Balali-Mood Chapter 4: Monoamine Oxidase Inhibitors and Tricyclic Antidepressants Terry J. Danielson Chapter 5: Selective Serotonin Reuptake Inhibitors Mojdeh Mozayani and Ashraf Mozayani Chapter 6: Antipsychotic Drugs and Interactions: Implications for Criminal and Civil Litigation Michael Welner Part II. Cardiovascular Drugs Chapter 7: Cardiovascular Drugs Johann Auer Part III. Antibiotics Chapter 8: Antimicrobial Drugs Amanda J. Jenkins and Jimmie L. Valentine Chapter 9: Drug Interactions with Medications Used for HIV/AIDS Michael Frank Part IV. Nonsteroidal Antiinflammatory Drugs Chapter 10: Nonsteroidal Antiinflammatory Drugs: Cyclooxygenase Inhibitors, Disease-Modifying Antirheumatic Agents, and Drugs Used in Gout Imad K. Abukhalaf, Daniel A. von Deutsch, Mohamed A. Bayorh, and Robin R. Socci Part V. Environmental and Social Pharmacology Chapter 11: Food and Drug Interactions Shahla M. Wunderlich Chapter 12: Alcohol and Drug Interactions A. Wayne Jones Chapter 13: Nicotine and Tobacco Edward J. Cone, Reginald V. Fant, and Jack E. Henningfield Chapter 14: Anabolic Doping Agents Daniel A. von Deutsch, Imad K. Abukhalaf, and Robin R. Socci Part VI. Legal Aspects Chapter 15: Drug Interaction Litigation Stephen A. Brunette Chapter 16: Psychotropic Medications and Crime: The Seasoning of the Prozac Defense Michael Welner Index
EPICARDIAL ADIPOSE TISSUE THICKNESS A NOVEL CARDIOMETABOLIC RISK IN HYPERTENSIVE OBESE ADULTS

INTRODUCTION :-Obesity is a independent risk factor for DM, HTN, OSA, stroke, MI, Arrhythmias etc.Epicardial Adipose Tissue (EAT)is a lipid-storing depot (an endocrine organ) secreting cytokines & chemokines So it could play roles in the pathogenesis of coronary atherosclerosis & cardiomyopathy AIM/OBJECTIVE :-Study Epicardial Adipose Tissue (EAT) as an independent prognostic marker in hypertensive obese adult as recent cardiovascular risk marker and its comparison with Body mass index(BMI). MATERIAL & METHOD:- All adults patient attending the Medicine OPD in two year duration were enrolled in the study.Anthropometric data collection :-Weight(Kg), Height(cm), Waist Circumference(cm), Hip Circumference(cm). Echocardiography was performed after anthropometric measurements.Two dimensional targeted M-mode measurement of EAT as recommended by American Society of echocardiography(ASE). RESULT:- The BMI was found higher in the experimental group 42.48(+/-7.35)than control group 21.69(+/-3.32). BSA & WHR both were significantly higher in experimental than control group.EAT are significantly higher in experimental group than control group. CONCLUSION:- Reduction in BMI , marker of Obesity will lead to improvement of epicardial adipose tissue thickness& will likely to prevent further cardiovascular morbidity &mortality ”
A multiple cause of death approach to racial/ethnic differences in infant mortality.

This analysis examines infant mortality for Hispanics Blacks and Anglos in Florida specific to cause of death. A unique data set is used which combines linked birth and death certificate information for the 412876 live births in the state 1980-1982 with National Center for Health Statistics (NCHS) multiple-cause coding of death records for the state during the 1980-1983 period. Based on the multiple cause information a 10 category scheme of cause of death is developed reflecting the principal diagnostic syndrome. Analysis shows that there are substantial differences in infant mortality among racial/ethnic groups in the state both overall and for specific causes of death. Overall differentials in infant mortality rates among some Hisp0anic subgroups approximate the 2:1 ratio typically characteristic of Black-White comparisons. Hispanics as a group generally exhibit lower than average odds of death while Blacks exhibit higher than average mortality rates. However background characteristics affect the extent of ethnic differences and when these are controlled differentials are erased for several causes of death and the pattern of inequality reversed in 1 case for Blacks. However the analysis does not fully account for racial/ethnic mortality differentials from several causes especially those which dominate during the postneonatal period. (authors)
An Overview of Children's Physical Activity and Coronary Heart Disease Risk

&NA; Coronary heart disease (CHD) rarely occurs in children; therefore pediatric research focuses on the relationship of physical activity to traditional CHD risk factors. Generally these studies report moderate associations between physical activity and CHD risk factors such as body fat, blood pressure, and blood lipids. Recently several studies have found that physical activity tends to track from childhood to adulthood. These studies suggest that public health strategies which promote childhood activity may improve habitual physical activity in adults. In response to accumulating research examining physical activity and health, federal and private organizations have published health‐related physical activity guidelines for children and adolescents. These guidelines are based on the concept of a lifetime of physical activity. Health care professionals can help implement these guidelines by: counseling children and parents, serving as role‐models, and supporting school and community based resources and programs which make physical activity accessible and safe for all children.
Effects of dietary garlic supplements on serum lipid profiles, LDL oxidation and weight gain in Western diet-fed rats

Background/Objective: Garlic (Allium sativum) has beneficial effects on hypercholesterolemia associated with cardiovascular disease. However, some studies have failed to support the favorable effect of garlic on blood lipid levels. This study was designed to investigate the effect of garlic intake on serum lipids, lipoprotein profiles, low-density lipoprotein (LDL) oxidation and weight gain in rats fed a Western-style diet containing high proportions of fat, cholesterol and refined sugars. Methods: A total of 32 male Wistar rats were divided into four groups and fed one of the following diets for 14 weeks: chow diet (normal control group), Western diet (Western diet control group, WDC) and Western diet including 5% (WD-5G) or 10% garlic (WD-10G). Results: The Western diet significantly increased total cholesterol, LDL cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, atherogenic index and LDL/HDL ratio, and lowered HDL, in comparison to the normal control group. LDL oxidation was increased by the Western diet, and greater differences were observed in group WD-5G vs. group WD-10G. Total cholesterol, LDL cholesterol and non-HDL cholesterol were significantly higher in group WD-10G than in group WDC. Weight gain was significantly lower in both garlic supplementation groups. Conclusion: Our data do not support the beneficial effects of garlic on serum LDL oxidation and lipid profile in rats fed a Western diet. Dietary pattern may be an important factor that influences the atheroprotective properties of garlic.
Retinal tracking system design for smart flashblindness non lethal weapon

Development of a non lethal method of providing incapacitation of human subjects is of primary importance in both law enforcement and military fields. The proposed Smart White Light Dazzler is such a device that induces flashblindness in the subject using a flash of white light. It is intended to automatically track the retina of a human subject, and then make adjustments to the power of the flash based on factors that affect the susceptibility of the eye. Temporary blindness is induced in the subject without risking permanent tissue damage. The primary contribution of this research is the design of a single axis tracking mechanism that uses a dual Alvarez lens system to deflect an outgoing probe beam directly onto a subject's retina. The system design uses a 630 nm laser, pulsed at 1000Hz, to locate and track a targeted synthetic retina. The position of the retroreflection of the probe beam from a synthetic eye is measured with a photo-sensitive silicon quadrant detector. The detected signal is processed to produce an appropriate motion control signal using a TI C2000 microprocessor. The signal processing algorithm employs basic Fourier principles to measure amplitude of signals reflected from the eye and affords the appropriate response signals to the motors controlling the lens position. Preliminary experimentation shows the ability of the tracking system to deflect the probe beam so that it is able to follow a synthetic eye.
A study on Recognition and Preference of Healthy and Functional Textile according to Psychological Comfort of the Silver Generation

The purposes of this study were to investigate difference on recognition, preference, satisfaction and pos- session of functional textile clothing in psychological comfort groups according to gender and age of the elderly and sug- gest optimal physical, mental and healthy functional textiles for the elderly. The data was collected from 262 respondents in their age of over 55, who lived in Busan. SPSS 21.0 was used and t-test, cross tabulation analysis, frequency analysis, and descriptive analysis were performed for analysis. The results are as follows. First, high groups of psychological com- fort for both gender and age of the elderly showed higher recognition and preference of functional textiles, especially in the high groups of the new silver generation and women. Second, the high groups of psychological comfort for both gen- der and age of the elderly showed higher satisfaction of functional textiles. However, it was lower than preference of func- tional textiles. Last, the possession of major clothing function over all the elderly was comfort, fitting·motion adaptability, and health·safety function in order. Low groups of psychological comfort possessed fitting·motion adaptability textile cloth- ing more than the high groups, and the high groups of psychological comfort possessed comfort and health·safety textile clothing more than low groups. In conclusion, this research showed the importance of functional textiles for the elderly in terms of psychological comfort as well as the need for healthy·comfort textiles for the advanced activities of daily life.
Profile of Patients Receiving Stroke Rehabilitation in A Tertiary Care Hospital

Background: Stroke rehabilitation is a program designed to help the stroke patients to overcome the disability. Few studies have evaluated the profile of stroke patients. To provide information about demographic data & disease pattern among the patients receiving stroke rehabilitation. Methods: A retrospective study was carried out in the Department of Physical Medicine and Rehabilitation (PMR), National Institute of Neuroscience and Hospital (NINSH) Dhaka, Bangladesh for the period of two year from 1st July 2013 to 30th June, 2015. Results: Total five thousand nine hundred thirty nine (n=5939) patients were studied, of which 62.33% were male and 37.67% were female. Maximum patients (27.93%) belong to 51-60 years of age. Major patients (52.67%) came from Dhaka city and most of the studied patients were housewife (25.43%). Largest disease group was ischaemic stroke (81.7%). Regarding service pattern, 69.59% patients received outdoor and 30.41% indoor services. Among clinical profile of stroke, 90.5% were first time onset, almost 99% suffered limb weakness, 24.03% speech problem and 32.6% face involvement. Maximum patients (58.8%) had history of multiple risk factors. Conclusion: Rehabilitation procedures in stroke patients can enable greater return of neurological functions and prevents complication, thereby improves long term outcome and quality of life. Chatt Maa Shi Hosp Med Coll J; Vol.17 (1); Jan 2018; Page 9-12