Miracle-dz/UniFAR-FTUs huggingface dataset:
Sodium bicarbonate versus sodium chloride and oral N-acetylcysteine for the prevention of contrast-induced nephropathy in advanced chronic kidney disease.

INTRODUCTION Contrast-induced acute kidney injury (CI-AKI) is one of the leading causes of hospital-acquired acute kidney injury. Multiple clinical studies have proposed several preventive strategies. AIMS To examine the efficacy of sodium bicarbonate compared with sodium chloride and oral N-acetylcysteine (NAC) for preventive hydration after cardiac catheterization. METHODS We conducted a prospective, single-center trial. Patients with chronic kidney disease (CKD) stage III-IV undergoing cardiac catheterization were allocated to receive either an infusion of 0.9% sodium chloride and oral NAC or 154 mEq/L sodium bicarbonate. MAIN: Outcome measure CI-AKI, defined as an increase of 25% or 0.3 mg/dL or more in plasma creatinine within 2 days of contrast administration. RESULTS Ninety-three patients were allocated to one of the two groups: 42 patients in the saline plus NAC group and 51 patients in the bicarbonate group. There were no statistically significant differences between the groups in the most important clinical and procedural characteristics. Baseline plasma creatinine levels, estimated glomerular filtration rate, incidence of diabetes mellitus, hypertension, congestive heart failure, and contrast medium volume were similar. Mean plasma creatinine concentration was 1.76 +/- 0.54 mg/dL in the saline and NAC group and 1.9 +/- 1 mg/dL in the bicarbonate group (P = 0.23). The rate of CI-AKI was 9.8% in the bicarbonate group and 8.4% in the saline plus NAC group. No patient required renal replacement therapy. CONCLUSION Hydration with sodium bicarbonate is not more effective than hydration with sodium chloride and oral NAC for prophylaxis of CI-AKI in patients with CKD stage III-IV undergoing cardiac catheterization.
Lack of mismatch correction facilitates genome evolution in mycobacteria

In silico genome sequence analyses suggested that mycobacteria are devoid of the highly conserved mutLS‐based post‐replicative mismatch repair system. Here, we present the first biological evidence for the lack of a classical mismatch repair function in mycobacteria. We found that frameshifts, but not general mutation rates are unusually high in Mycobacterium smegmatis. However, despite the absence of mismatch correction, M. smegmatis establishes a strong barrier to recombination between homeologous DNA sequences. We show that 10–12% of DNA sequence heterology restricts initiation of recombination but not extension of heteroduplex DNA intermediates. Together, the lack of mismatch correction and a high stringency of initiation of homologous recombination provide an adequate strategy for mycobacterial genome evolution, which occurs by gene duplication and divergent evolution.
What Triggers the Intention to Use the European Citizens’ Initiative? The Role of Benefits, Values and Efficacy

The European Citizens’ Initiative (ECI) is a European Union instrument that aspires to encourage citizens to participate in EU policy‐making. Although scholarly interest in the ECI is strong, only isolated studies have examined the factors that shape the intention to use it. This article fills a gap in the literature by examining how personal benefits from the EU, value‐based assessments of the EU, and political efficacy (internal and external) may trigger potential use of the ECI. It develops a model that is tested with recent Eurobarometer data. Results show that personal benefits from the EU are key determinants of the intention to use the ECI while considerations based on democratic values play a less important role. In addition, internal political efficacy emerges as a strong predictor of potential use. The results challenge the expectation that the ECI could broaden public engagement with EU affairs.
Students' Perceptions of Safety on a Campus in Relation to Firearms

This study will utilize a qualitative approach to better understand students' perceptions of safety on-campus in relation to firearms. Results found that participants felt safe oncampus due to its rural setting. Determination of geographical upbringing was noted as influential overall in perceptions of firearms. Participants were more confident with faculty having concealed firearms than students. Results also indicated that students have a lack of knowledge when it came to state legislation, their university's policies, and the protocol in place at their university in response to a mass shooting. Students reflected Perry's (20 1 0) multiplicity stage of development appropriate for this age group. Recommendations to the University Police Department, and University Housing and Dining were provided to gain insight into the challenges and developmental factors that face students who chose to live on campus.
Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1

The structure provides insight into how protein synthesis is initiated and into the evolution of the eukaryotic ribosome. Eukaryotic ribosomes are substantially larger and more complex than their bacterial counterparts. Although their core function is conserved, bacterial and eukaryotic protein synthesis differ considerably at the level of initiation. The eukaryotic small ribosomal subunit (40S) plays a central role in this process; it binds initiation factors that facilitate scanning of messenger RNAs and initiation of protein synthesis. We have determined the crystal structure of the Tetrahymena thermophila 40S ribosomal subunit in complex with eukaryotic initiation factor 1 (eIF1) at a resolution of 3.9 angstroms. The structure reveals the fold of the entire 18S ribosomal RNA and of all ribosomal proteins of the 40S subunit, and defines the interactions with eIF1. It provides insights into the eukaryotic-specific aspects of protein synthesis, including the function of eIF1 as well as signaling and regulation mediated by the ribosomal proteins RACK1 and rpS6e.
Integrated Transcriptome Map Highlights Structural and Functional Aspects of the Normal Human Heart

A systematic meta‐analysis of the available gene expression profiling datasets for the whole normal human heart generated a quantitative transcriptome reference map of this organ. Transcriptome Mapper (TRAM) software integrated 32 gene expression profile datasets from different sources returning a reference value of expression for each of the 43,360 known, mapped transcripts assayed by any of the experimental platforms used in this regard. Main findings include the visualization at the gene and chromosomal levels of the classical description of the basic histology and physiology of the heart, the identification of suitable housekeeping reference genes, the analysis of stoichiometry of gene products, and the focusing on chromosome 21 genes, which are present in one excess copy in Down syndrome subjects, presenting cardiovascular defects in 30–40% of cases. Independent in vitro validation showed an excellent correlation coefficient (r = 0.98) with the in silico data. Remarkably, heart/non‐cardiac tissue expression ratio may also be used to anticipate that effects of mutations will most probably affect or not the heart. The quantitative reference global portrait of gene expression in the whole normal human heart illustrates the structural and functional aspects of the whole organ and is a general model to understand the mechanisms underlying heart pathophysiology. J. Cell. Physiol. 232: 759–770, 2017. © 2016 Wiley Periodicals, Inc.
Determining Tissue of Origin for Metastatic Cancers: Meta-analysis and Literature Review of Immunohistochemistry Performance

BackgroundPathologists use various panels of immunohistochemical (IHC) stains to identify the site of tissue of origin for metastatic tumors, particularly poorly or undifferentiated cancers of unknown or uncertain origin. Although clinicians believe that immunostains contribute greatly to determining the probable primary site among 3 or more possibilities, objective evidence has not been convincingly presented. This meta-analysis reviews the objective evidence supporting this practice and summarizes the performance reported in 5 studies published between 1993 and 2007. MethodsA literature search was conducted to identify IHC performance studies published since 1990 that were masked, included more than 3 tissues types, and used more than 50 specimens. The 5 studies found in this search were separated into 2 subgroups for analysis: those, which included only metastatic tumors (n=368 specimens) and the blended studies, which combined primary tumors and metastases (n=289 specimens). ResultsThe meta-analysis found that IHCs provided the correct tissue identification for 82.3% (95% confidence interval=77.4%-86.3%) of the blended primary and metastatic samples and 65.6% (95% confidence interval=60.1%-70.7%) of metastatic cancers. This difference is both clinically and statistically significant. ConclusionsThis literature review confirms that there is still an unmet medical need in identification of the primary site of metastatic tumors. It establishes minimum performance requirements for any new diagnostic test intended to aid the pathologist and oncologist in tissue of origin determination.
Human Capital: Parental Aspirations, Ethnic Differences and Crime

This thesis comprises three empirical papers. Using various econometric techniques, each paper examines different aspects of human capital. These aspects vary from determinants of human capital to heterogeneity in human capital, and to non-economic benefit of human capital. The objective of this thesis is to obtain a better understanding about issues related human capital and education in developing countries, in particular Indonesia and Vietnam. The first research paper examines the role of parental academic aspirations for a child in determining the allocation of the child’s time. Parental academic aspirations are included in a theoretical model of household utility maximization to assess how they affect the child’s optimal time allocation. Then, an empirical analysis is conducted to verify the effect of parental aspirations on a child’s hours of study and work by using data from the 2006 and 2014 Vietnam Young Lives Survey. The instrumental variable approach is adopted to address a problem related to the simultaneity of decision making process and endogeneity of parental aspirations. Both the theoretical and empirical results show that parental academic aspirations are positively associated with the child’s hours of study and negatively associated with the child’s hours of work. The second research paper seeks to understand the reasons for the ethnic gaps in education outcomes, measured by enrolment rate, schooling progress and test scores, in Vietnam. The examination employs Probit and multilevel regression models, and associated decomposition techniques. The estimation results suggest that the factors mainly driving the poor performance at school of minority children are not their own internal attributes, but disadvantages related to the external
Daily activities and hand function in women with scleroderma

Objective: To give a detailed description of hand function and the ability to perform daily activities among patients with systemic sclerosis. Methods: Thirty patients with scleroderma answered a self‐administered activities of daily living (ADL) questionnaire. Hand function was estimated with respect to hand mobility, dexterity, and grip force. Perceived symptoms were reported on a visual analogue scale (VAS), and skin thickness was assessed by means of the modified Rodnan skin score. Results: Finger flexion and extension were the most impaired aspects of hand mobility. Dexterity was on average reduced to 68–80%, and grip force to 46–65% compared with values for healthy persons. The predominant self‐perceived problem was Raynaud's phenomenon, whereas pitting scars/ulcers were perceived as the least problem. Activities building on hand and arm function were harder to perform than activities depending on lower limb function. Raynaud's phenomenon, stiffness, grip force, and dexterity were factors with the strongest associations with ADL difficulties. Assistive devices and alternative working methods improved ADL ability. Conclusion: Impaired hand function was related to ADL difficulties and the use of assistive devices improved ADL. This emphasizes the importance of treatments that improve hand function and of testing ergonomic tools.
Empirical Support for a Treatment Program for Families of Young Children With Externalizing Problems

We evaluated the efficacy of a manualized multimodal treatment program for young externalizing children. Families were assigned randomly to an immediate 12-week parent and child treatment condition (n = 24) or to a delayed-treatment condition (n = 23). Parents had high attendance, high satisfaction with treatment, and increased knowledge of behavior management principles. Relative to the waitlist condition, treatment parents reported statistically and clinically significant reductions in child behavior problems, improved parenting practices (i.e., increased consistency, decreased power assertive techniques), an increased sense of efficacy, and reduced parenting stress. There was a trend toward parents improving their attitudes toward their children. In considering the process of change, we found evidence that improved parenting practices mediated reductions in child behavior problems and that child improvements mediated changes in parent attitudes and stress. Five months following treatment, teachers reported significant improvements in child behaviors, whereas parents reported that reductions in child behavior problems and parenting stress were maintained.
Cerebellum in attention-deficit hyperactivity disorder

Clinical, neuroanatomic, neurobehavioral, and functional brain-imaging studies suggest a role for the cerebellum in cognitive functions, including attention. However, the cerebellum has not been systematically studied in attention-deficit hyperactivity disorder (ADHD). We quantified the cerebellar and vermal volumes, and the midsagittal areas of three vermal regions, from MRIs of 46 right-handed boys with ADHD and 47 matched healthy controls. Vermal volume was significantly less in the boys with ADHD. This reduction involved mainly the posterior inferior lobe (lobules VIII to X) but not the posterior superior lobe (lobules VI to VII). These results remained significant even after adjustment for brain volume and IQ. A cerebello-thalamo-prefrontal circuit dysfunction may subserve the motor control, inhibition, and executive function deficits encountered in ADHD.
Time Course of Macular and Peripapillary Inner Retinal Thickness in Non-arteritic Anterior Ischaemic Optic Neuropathy Using Spectral-Domain Optical Coherence Tomography

ABSTRACT To report a time course of the ganglion cell complex (GCC) and circumpapillary retinal nerve fibre layer (cpRNFL) thicknesses using spectral-domain optical coherence tomography in patients with non-arteritic anterior ischaemic optic neuropathy (NAION), five patients with unilateral NAION were studied (the average age of 66.8 ± 7.8 years old). Forty-one age-matched normal controls were also enrolled. The GCC and cpRNFL thicknesses were measured at the initial visit and at 1, 3, 6, and 12 months using RTVue-100. The GCC thickness and the cpRNFL thickness of the patients were compared with those of the normal controls. The GCC thickness in the NAION patients was 96.49 μm at the initial visit, 84.28 μm at 1 month, 74.26 μm at 3 months, 71.23 μm at 6 months, and 69.51 μm at 12 months. The values at 1, 3, 6, and 12 months were significantly reduced (p < 0.01). The cpRNFL thickness at the initial visit was significantly increased, whereas the values at 6 and 12 months were significantly reduced (p < 0.01). The GCC thickness is more useful for the detection of retinal ganglion cell loss at an early stage than the cpRNFL thickness, because the GCC thickness is unaffected by optic disc swelling at the initial visit, unlike the cpRNFL thickness.
Growth and Production of the Dengue Virus in C6/36 Cells and Identification of a Laminin-Binding Protein as a Candidate Serotype 3 and 4 Receptor Protein

Objectives: Although dengue is one of the most common mosquito-borne viral diseases, few studies have investigated the relationship between the dengue virus and mosquito cells, and this study sought to describe the binding and propagation of the dengue viruses in C6/36 cells. Methods: The internalization and production of the dengue virus was assayed by standard plaque assay methodologies, while dengue virus receptor proteins were examined by a virus overlay protein-binding assay and candidate gene analysis coupled with virus inhibition studies. Results: All four serotypes were internalized linearly, and de novo virus production occurred 14–19 h postinfection. Virus overlay protein-binding assay identified a band of 50 kDa for dengue serotypes 2, 3 and 4 which comigrated with a protein that reacts with antibodies directed against the human 37/67-kDa high-affinity laminin receptor. Both antibodies directed against the human 37/67-kDa high-affinity laminin receptor protein and soluble laminin inhibited the binding and internalization of serotypes 3 and 4, but not serotypes 1 and 2. Conclusions: The results suggest that multiple receptors may be used by the dengue virus to enter into insect cells, and that one of these proteins may be a laminin-binding protein.
Mammography in the 1990s: the United States and Canada.

PURPOSE To evaluate trends in mammography quality before and after the implementation of the Mammography Quality Standards Act (MQSA) of 1992 and to compare technical data collected in the United States with corresponding data obtained from the first survey of mammography facilities conducted in 1994-1995 in Canada. MATERIALS AND METHODS Data from MQSA inspections conducted in 1995-1997 were analyzed and compared with survey data on U.S. mammography facilities acquired before the MQSA. Technical indicators of mammography quality such as radiation dose phantom image score, film processing, and darkroom fog were analyzed. RESULTS In the United States, phantom image scores, along with other technical measures of performance such as film processing, darkroom fog, and x-ray beam quality, have improved continuously since 1985. The U.S. mean glandular dose has increased to 1.6 mGy compared with the Canadian dose of 1.1 mGy. The mean total phantom image score with artifact subtraction was 11.1 in Canada in 1994-1995 and 11.8 in the U.S. in 1997. CONCLUSION Mammography quality is better today than it has been at any other time in the United States. With the exception of radiation dose. Canadian technical measures of performance are comparable to measures before MQSA in the United States.
Talking about terrorism: An analysis of official Canadian insecurity narratives in the post-September 11 context

This study identifies the dominant characteristics of official Canadian state discourses on national security and terrorism in the post-September 11 context, using a content analysis methodology; identifies key themes and / or areas of incongruity in these discourses, and relates these findings to a broader discussion of contemporary Canadian national security policy and practice. Major themes of interest and key terms are identified through a review of the literature, and used as the basis for an analysis of twenty (20) samples of open-source official (federal government) Canadian discourse from the post-September 11 context. It is argued that state discourses about terrorism and security are a core component of national security campaigns, and that through the construction of insecurity narratives (constellations of discourse about a particular security threat), states effectively ‘do national security’. The study finds that the current Canadian insecurity narrative is characterized by themes of exceptionality, urgency, necessity, secrecy, and crisis – and consistent references to September 11 as a mobilizing event. The nature of this narrative is such that the current national security campaign is indeterminate in length, ambiguous in purpose, and expansionary in trajectory. 1 Mike Larsen was a student in the Department of Criminology, Faculty of Social Sciences at the University of Ottowa, Canada Internet Journal of Criminology © 2006 www.internetjournalofcriminology. com List of Tables and Figures Table / Figure Title Page Figure 1 – Core, Peripheral and Transitional Positions in National Security Discourses 71 Figure 2 – SafeCanada.ca – National Safety and Security Screenshot 93 Figure 3 – Discourse Sample Selection Process 96 Figure 4 – Sample Coding Scheme (Blank) 103 Figure 5 – Sample Coding Scheme (Completed) 105 Table 1 – Discourse Samples 161 Table 2 – Appearance of Terms 164 Table 3 – Summary of Findings 167
The Deposition of Paraguayan President Fernando Lugo and its repercussions in South American regional organizations

In June 2012, the Paraguayan Parliament executed a procedure that removed President Fernando Lugo from office. Since 1993, only two presidents have completed their mandates, Juan Carlos Wasmosy (1993-1998) and Nicanor Duarte Frutos (2003-2008). With the exception of the latter, all elected presidents have faced either successful or attempted coups, mostly organized by the military. In the case of Lugo, South American governments reacted by suspending Paraguay from two regional organizations (Unasur and Mercosur). This article has two main objectives: 01. to provide an interpretation of Fernando Lugo's deposition, in the context of the ongoing instability of Paraguay's democratic regime, as well as other similar cases in South America; and 02. to analyze the regional repercussions of the interruption of Lugo's presidential mandate, in particular the reactions from other South American governments and the ramifications for three Mercosur institutions: the Common Market Council (CMC), the Mercosur Parliament (Parlasur), and the Permanent Review Tribunal (TPR). It is argued that, despite the involvement of the parliamentary and judicial institutions of the bloc in the Paraguayan case, the governments have prevailed in both the suspension and reincorporation of Paraguay to the bloc, reinforcing both the intergovernmental nature of these regional initiatives and the prominence of national executives in regional decision-making.