Miracle-dz/UniFAR-FTUs huggingface dataset:
Living with dementia in a care home: capturing the experiences of residents

Purpose – The purpose of this paper is to consider the experiences and perspectives of residents with dementia living in a care home.Design/methodology/approach – The paper reviews current sources of evidence about “the care home experience”, including material drawn from: research instruments, interviews, observational methods and phenomenological research which aims to capture the lived experiences of residents.Findings – Research that is attempting to capture the lived experiences of residents further adds to the understanding of quality of life (QoL) and quality of care. Specifically, residents prioritise non‐disease‐related domains of QoL, which is somewhat different than those identified by relatives, care home staff and “objective” measures.Originality/value – Not only is it evident that residents are able to describe aspects of their situation but they appear to retain a sense of self and identity. There is a distinctive need for assessment of QoL amongst residents with dementia that places their .
The Nature, Cause, and Extent of Occupational Musculoskeletal Injuries among Sonographers

Concerns regarding injury rates, as well as resulting discomfort and disability, among sonographers led to a needs assessment across 13 work sites. General sonographers completed 82,642 exams in 2001-2002. Sick time and workers’ compensation costs of more than $180,000 occurred due to worker disability in the same time period. In an effort to improve working conditions and retain workers, funding was allocated to assess the problem and provide recommendations to prevent and manage the injuries more effectively. A survey was administered across the sector to 76 sonographers. The respondent rate was 88%. The results describe the nature of injury, types of scans causing discomfort, effectiveness of various treatments and providers, and workers’ feelings regarding work organization and culture. The results identify and validate the need for action. Recommendations include a standardized approach for treatment, education, and ergonomic work site training as well as prescreening of students for injury risk factors.
Feasibility of early hospital discharge directly from coronary care unit after primary angioplasty for uncomplicated acute myocardial infarction

Current European and American guidelines recommend early discharge for patients with uncomplicated acute myocardial infarction (AMI). However, this concept has not been widely accepted, and experience with direct discharge from the coronary care unit is limited. We aimed to investigate safety and cost effectiveness of early discharge directly from coronary care unit following successful percutaneous coronary angioplasty (PTCA) in patients with uncomplicated AMI. We included consecutive thirty-one patients with uncomplicated AMI and successful PTCA admitted to coronary care unit of a university hospital. Uncomplicated course was defined as absence of reinfarction, ischemia, VF/VT, repeated PTCA, and heart failure within first 72 hours. Incidence of death, reinfarction, VF/VT, need for revascularisation, and hospitalisation due to heart failure at 1, 6, and 12 months was compared with 56 randomly selected AMI patients with successful PTCA but longer hospitalisation. Average hospital stay was 4 days in early and 6.7 days in control group (p<0.05). Control group had more extensive coronary disease (54% two or more vessels vs. 28% in early discharge, p<0,05). During follow up, none of the early discharged patients died, the only observed event was repeat PTCA due to angina pectoris. In the control group, mortality at 12 months was 3.5% (p<0.05). Cumulative 12 month event free survival was 96% in early discharge group and 87% in control group, but difference was not significant (p=0.15, Cox-Mantel test). Cost reduction of early discharge amounted to 1100 Euro per patient. In conclusions, our study confirmed that for a selected population of patients with AMI, successful PTCA, and uncomplicated clinical course during first 72 hours, discharge as early as three days following the admission is safe.
The value of 18F‐fluorodeoxyglucose positron emission tomography for prediction of treatment response in gastrointestinal stromal tumors: a systematic review and meta‐analysis

Early detection of response to treatment is critically important in gastrointestinal stromal tumors (GIST). Therefore, the present systematic review and meta‐analysis assessed the value of 18f‐fluorodeoxyglucose positron emission tomography (18FDG–PET) on prediction of therapeutic response of GIST patients to systemic treatments.
Osteoprotegerin: A novel biomarker for inflammatory bowel disease and gastrointestinal carcinoma

Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily of proteins. Although initial data illustrated the key role that OPG plays in bone turnover, numerous recent reports indicate that OPG is also an important factor in inflammatory pathways and tumor cell survival. OPG contributes directly to inflammatory processes and has been evaluated as a novel non‐invasive biomarker of gut inflammation. Furthermore, OPG affects cell turn‐over, differentiation, death, and survival via extracellular pathways, correlating with worse prognosis in inflammatory bowel diseases and several gastrointestinal carcinomas. It is now clear that OPG has multiple functions and characteristics. This review gives an overview of OPG, highlights its roles in different extracellular pathways, and outlines how OPG could be used as a novel non‐invasive biological marker in inflammatory bowel diseases and gastrointestinal carcinomas.
Mesenteric Lymph Return Is an Important Contributor to Vascular Hyporeactivity and Calcium Desensitization After Hemorrhagic Shock

ABSTRACT Vascular hyporeactivity is an important factor in irreversible shock, whereas calcium desensitization is one of the mechanisms of vascular hyporeactivity, and the intestinal lymphatic pathway plays an important role in multiple organ injury after severe hemorrhagic shock (HS). In this study, our aims were to determine the effects of mesenteric lymph on vascular reactivity during HS and the mechanisms involved. First, the in vivo pressor response was observed by intravenous injection of norepinephrine (3 &mgr;g/kg) at different time points after HS. We found that mesenteric lymph duct ligation (MLDL) and mesenteric lymph drainage (MLD) enhanced the pressor response at multiple time points after shock. Next, vascular reactivity and calcium sensitivity in superior mesenteric artery (SMA) vascular rings were examined using an isolated organ perfusion system. Vascular reactivity and calcium sensitivity were higher for SMA rings from rats that had undergone HS plus MLDL or MLD that those from rats that had undergone only HS. The effects of MLDL and MLD on vascular reactivity and calcium sensitivity were significantly increased following incubation with the calcium sensitizer angiotensin II and were reduced after incubation with the calcium sensitivity inhibitor insulin. When SMA rings from normal rats were incubated with mesenteric lymph from rats subjected to HS, lymph obtained 0 to 0.5 h after shock enhanced vascular reactivity and calcium sensitivity, whereas lymph obtained 1 to 3 h after shock blunted these effects. We finally examined vascular reactivity and calcium sensitivity in HS rats subjected to MLD at 0 to 3 h or 1 to 3 h after shock. We found that contractile activity of SMAs in response to norepinephrine or Ca2+ was higher in HS rats subjected to MLD at 1 to 3 h after shock compared with rats subjected to MLD at 0 to 3 h after shock. These results indicate that mesenteric lymph return plays an important role in biphasic changes in vascular reactivity during HS. Even more importantly, mesenteric lymph 1 h after shock was an important contributor to vascular hyporeactivity, and its mechanism of action was related to calcium desensitization. Targeting lymph may therefore have therapeutic potential in the treatment of severe shock-induced hypotension.
TREATMENT OF THREATENED PREMATURE LABOUR WITH ALCOHOL

ANNA-RIITTA F u c ~ s has demonstrated that normal parturition in the rabbit is initiated by a sudden release of a large amount of oxytocin from the neurohypophysis and that this releaseand thereby labour-can be inhibited by infusion of ethyl alcohol (Fuchs, 1964, 1965). With Wagner (1963) she could also demonstrate that alcohol inhibits the neurohumoral milk ejection reflex both in rabbits and women. Contrary to old midwives’ tales, alcohol in sufficient quantities reduces rather than increases the amount of milk available to the baby. In North America, alcohol has been used as an obstetric analgesic in many places, and several reports can be found in the literature. About half of them contain the statement that if alcohol is
SEMINARS IN RESPIRATORY MEDICINE—VOLUME 12, NUMBER 4, OCTOBER 1991 Central and Transmission Fatigue

Inspiratory muscle fatigue occurs when the load against which the muscles must contract requires too great an effort for too long a period of time. In theory, fatigue could be brought about by impaired operation of any part of the command chain for muscle contraction: volition, integration of voluntary and involuntary influences on central respiratory drive, neural and neuromuscular transmission, excitation-contraction coupling, or the interaction of the contractile proteins (Fig. 1). It is clear that different circumstances result in different patterns of fatigue and that more than one pathophysiologic mechanism may often participate in respiratory muscle fatigue. This chapter will focus on the more proximal sites of fatigue and will review the evidence that central and transmission mechanisms participate in inspiratory muscle fatigue.
Fecal neutrophil gelatinase‐associated lipocalin as a biomarker for inflammatory bowel disease

Accurate, noninvasive biomarkers are needed to diagnose and monitor inflammatory bowel disease (IBD). Neutrophil gelatinase‐associated lipocalin (NGAL), also known as lipocalin 2, is expressed in inflamed colonic epithelium and neutrophilic granulocytes. This study explores its properties as a biomarker in feces and plasma and, for the first time, compares fecal NGAL systematically with the existing fecal biomarker calprotectin.
Effect of Short-term Treatment with Perindopril, Torsemide and Restricted-sodium Diet in Dogs with Atrioventricular Valvular Insufficiency

Abstract Caro-Vadillo, A. , Ynaraja-Ramirez, E. and Montoya-Alonso, J.A. 2006. Effect of short-term treatment with perindopril, torsemide and restricted-sodium diet in dogs with atrioventricular valvular insufficiency. J. Appl. Anim. Res., 29: 105–108. To evaluate the effects of perindopril, torsemide and a low-sodium diet on clinical response in dogs with moderate congestive heart failure, forty-six dogs with moderate congestive heart failure (International Small Animal Cardiac Health stage II) due to mitral valve disease were taken. During 4 weeks all the patients received 0.2 mg/kg perindopril (Coversyl, Servier) SID, 0.2 mg/kg torsemide (Sutril, Novag) SID and a moderate-sodium diet (k/d, Hill's). The treatment was safe, effective and well-tolerated and no major side-effects were observed. There were no significant changes in measured haematological and biochemical variables, including serum electrolyte concentrations and urinary fractional excretion of electrolytes. At the end of the study, all the patients improved with regard to clinical symptoms. The combined treatment with perindopril, torsemide and a restriction-sodium diet is simple, safe and effective therapeutic option for dogs with congestive heart failure secondary to atrioventricular valvular insufficiency.
Serotonergic, sensory modifications in the apical ganglion during development to metamorphic competence in larvae of the dendronotid nudibranchs Melibe leonina and Tritonia diomedea

The following investigation examines changes in the distance between the right and left dendritic termini arising from the serotonergic sensory neurons found in the apical ganglion of the larval dendronotid nudibranchs, Melibe leonina and Tritonia diomedea. A significant increase in separation, that is different in extent, occurs in both species as they grow from hatching to metamorphic competence. Competent M. leonina larvae exhibit a separation that is about 4.5 times that at hatching, whereas competent larvae of T. diomedea show an increase that is only 1.6times that at hatching. The increase in separation of the lateral, serotonergic, dendritic termini (particularly in M. leonina) may allow the larva to more effectively assess left versus right differences in an as yet unknown sensory stimulus. The serotonergic innervation that arises from the apical ganglion is known to be associated with the muscles and large ciliated cells of the velum. Better right versus left discrimination of sensory stimuli experienced during the pelagic or settling larval phases may allow the larva to more precisely control swimming activities such that the likelihood of successful feeding or settlement behavior is increased. Microsc. Res. Tech., 2008. © 2008 Wiley‐Liss, Inc.
Morphological alterations of radicular dentine pretreated with different irrigating solutions and irradiated with 980‐nm diode laser

Background: The topographical features of intraradicular dentine pretreated with sodium hypochlorite (NaOCl) or ethylenediamine tetraacetic acid (EDTA) followed by diode laser irradiation have not yet been determined. Purpose: To evaluate the alterations of dentine irradiated with 980‐nm diode laser at different parameters after the surface treatment with NaOCl and EDTA. Study design: Roots of 60 canines were biomechanically prepared and irrigated with NaOCl or EDTA. Groups were divided according to the laser parameters: 1.5 W/CW; 1.5 W/100 Hz; 3.0 W/CW; 3.0 W/100 Hz and no irradiation (control). The roots were splited longitudinally and analyzed by scanning electron microscopy (SEM) in a quali‐quatitative way. The scores were submitted to two‐way Kruskal–Wallis and Dunn's tests. Results: The statistical analysis demonstrated that the specimens treated only with NaOCl or EDTA (control groups) were statistically different (P < 0.05) from the laser‐irradiated specimens, regardless of the parameter setting. The specimens treated with NaOCl showed a laser‐modified surface with smear layer, fissures, and no visible tubules. Those treated with EDTA and irradiated by laser presented absence of smear layer, tubules partially exposed and melting areas. Conclusions: The tested parameters of 980‐nm diode laser promoted similar alterations on dentine morphology, dependent to the type of surface pretreatment. Microsc. Res. Tech., 2009. © 2008 Wiley‐Liss, Inc.
The illusion of prostate-specific antigen decline in patients with metabolic syndrome and insulin resistance

Studies have shown that PSA is negatively associated with obesity as a result of hemodilution or metabolic effect. Hemodilution could be the main reason for low PSA levels in obese men. However, the intrinsic metabolic effects such as insulin resistance (IR) or metabolic syndrome (MS) on PSA level have not been clearly evaluated although obesity is closely tied to MS and IR.We regarded MS and IR as the pathophysiological cornerstone of metabolic disorder in obesity and analyzed the relationships among MS, IR, and PSA levels, and plasma volume by using the concept of PSA mass, the total circulating PSA protein. PSA mass did not change depending on the severity of the obesity, MS or IR. Even the group with both MS and IR, which could be the most metabolically disturbed in this study, did not have different PSA mass, comparing with the group without any MS or IR. Thus, the decline in PSA level in men with MS or IR can be also explained by increased plasma volume other than any intrinsic metabolic effects.
Global/local head models to analyse cerebral blood vessel rupture leading to ASDH and SAH

Blunt and rotational head impacts due to vehicular collisions, falls and contact sports cause relative motion between the brain and skull. This increases the normal and shear stresses in the (skull/brain) interface region consisting of cerebrospinal fluid (CSF) and subarachnoid space (SAS) trabeculae. The relative motion between the brain and skull can explain many types of traumatic brain injuries (TBI) including acute subdural hematomas (ASDH) and subarachnoid hemorrhage (SAH) which is caused by the rupture of bridging veins that transverse from the deep brain tissue to the superficial meningeal coverings. The complicated geometry of the SAS trabeculae makes it impossible to model all the details of the region. Investigators have compromised this layer with solid elements, which may lead to inaccurate results. In this paper, the failure of the cerebral blood vessels due to the head impacts have been investigated. This is accomplished through a global/local modelling approach. Two global models, namely a global solid model (GSM) of the skull/brain and a global fluid model (GFM) of the SAS/CSF, were constructed and were validated. The global models were subjected to two sets of impact loads (head injury criterion, HIC = 740 and 1044). The relative displacements between the brain and skull were determined from GSM. The CSF equivalent fluid pressure due to the impact loads were determined by the GFM. To locally study the mechanism of the injury, the relative displacement between the brain and skull along with the equivalent fluid pressure were implemented into a new local solid model (LSM). The strains of the cerebral blood vessels were determined from LSM. These values were compared with their relevant experimental ultimate strain values. The results showed an agreement with the experimental values indicating that the second impact (HIC = 1044) was strong enough to lead to severe injury. The global/local approach provides a reliable tool to study the cerebral blood vessel ruptures leading to ASDH and/or SAH.
Imaging of mouse experimental melanoma in vivo and ex vivo by combination of confocal and nonlinear microscopy

We investigated possibilities of the combination of the one‐ and two‐photon excitation microscopy for examination of the experimental melanoma tissue in vivo, in mice under general anesthesia, and ex vivo on freshly harvested specimens. Our aim was to obtain sufficiently informative images of unstained tumor tissues and their modifications after hyperthermia treatment. The mouse experimental melanoma structure was studied and compared with normal tissue from the same animal by using confocal and nonlinear microscopy techniques based on (i) one‐photon excitation (1PE) fluorescence, (ii) 1PE reflectance, (iii) second harmonic generation imaging, and (iv) two‐photon excitation autofluorescence. We checked different spectral conditions and other settings of image acquisition, as well as combinations of the above imaging modalities, to fully exploit the potential of these techniques in the evaluation of treated and untreated cancer tissue morphology. Our approach enabled to reveal the collagen fiber network in relation with the other tissues, and to identify invasive tumor cells. It also proved to be useful for the examination of interrelationships between functional and morphological aspects based on optical properties of the tissues, especially in studies of changes between the tumor and control tissue, as well as changes induced by physical treatments, e.g., delivery of microwave hyperthermia treatment. These differences were also evaluated quantitatively, when we found out that the maximum Euler–Poincaré characteristic reflects well the melanoma morphological structure. The results showed that the proposed investigative approach could be suitable also for a direct evaluation of tissue modifications induced by clinical interventions. Microsc. Res. Tech., 2009. © 2009 Wiley‐Liss, Inc.
Serum S100B Protein Is Increased and Correlates With Interleukin 6, Hypoperfusion Indices, and Outcome in Patients Admitted for Surgical Control of Hemorrhage

ABSTRACT S100B protein, an acknowledged biomarker of brain injury, has been reported to be increased in hemorrhagic shock. Also, acute hemorrhage is associated with inflammatory response. The aim of this study was to investigate the concentrations of serum S100B and the potential relationships with interleukin 6 (IL-6), severity of tissue hypoperfusion, and prognosis in patients admitted for surgical control of severe hemorrhage. Patients undergoing elective abdominal aortic aneurysm surgery participated as control subjects. Serum samples were drawn before, at the end of surgery, and after 6 and 24 h. Sixty-four patients with severe hemorrhage (23 trauma and 41 nontrauma) and 17 control subjects were included. Increased preoperative concentrations of S100B protein (1.70 ± 2.13 and 0.81 ± 1.23 &mgr;g/L) and IL-6 (241 ± 291 and 226 ± 238 pg/mL) were found in patients with traumatic and nontraumatic reason, respectively, and remained elevated throughout 24 h. Compared with nontrauma, trauma patients exhibited higher preoperative S100B levels (P < 0.05). Overall mortality was 47%. In control subjects, preoperative S100B and IL-6 levels were within normal limits and increased at the end of surgery (P < 0.001 and P < 0.01, respectively). Preoperative S100B correlated with IL-6 (r = 0.78, P < 0.01), arterial lactate (r = 0.50, P < 0.01), pH (r = −0.45, P < 0.01), and bicarbonate (r = −0.40, P < 0.01). Multiple analysis revealed that preoperative S100B in trauma and lactate in nontrauma patients were independently associated with outcome. In predicting death, preoperative S100B yielded receiver operator characteristics curve areas of 0.75 for all patients and 0.86 for those with trauma. These results indicate that severe hemorrhage in patients without brain injury is associated with increased serum levels of S100B, which correlates with IL-6 and tissue hypoperfusion. Moreover, the predictive ability of S100B for mortality, suggests that it could be a marker of potential clinical value in identifying, among patients with severe hemorrhage, those at greater risk for adverse outcome.
Apoptotic DNA fragmentation can be revealed in situ: An ultrastructural approach

A common pattern of apoptotic death is DNA cleavage, initially producing large fragments (50 kbp), followed by the production of nucleosomic/oligonucleosomic fragments. Nevertheless, apoptosis without DNA fragmentation, at least of the nucleosomic type, has been reported. To investigate the spatial relationship between DNA cleavage and chromatin condensation, we applied the TUNEL technique to the ultrastructural analysis of apoptotic cells. A modified method, utilizing a gold‐conjugated antidigoxigenin antibody, was carried out on U937 versus Molt‐4 cells, both exposed to UVB radiation or staurosporine treatment. Gold particle density in the different domains of apoptotic cells was evaluated by a four‐way ANOVA test. Gold labelling was more strongly localised in condensed chromatin than in the diffuse chromatin. U937 cells, which evidenced in vitro oligonucleosomic fragmentation after both UVB and staurosporine treatments, revealed a significantly higher gold particle density, when compared with Molt‐4, which did not show, on the other hand, oligonucleosomic cleavage even in the presence of ≤50 kbp cleavage. Thus, a correlation between DNA fragment sizes and gold particle density appears. TUNEL applied to electron microscopy is an effective approach to study the relationship between apoptotic chromatin condensation and DNA cleavage. Both these events indeed appear in the apoptotic nucleus, but their reciprocal correlation is still greatly unknown. Microsc. Res. Tech. 2009. © 2009 Wiley‐Liss, Inc.