Miracle-dz/UniFAR-FTUs huggingface dataset:
Ectopic production of placental hormones (human chorionic gonadotropin and human placental lactogen) in carcinoma of the uterine cervix

Serum hCG and hPL levels were assayed simultaneously in patients with cervical carcinoma and were compared with those of a miscellaneous group of malignant conditions. It is apparent from the results that hCG secretion is of a much wider occurrence as compared to hPL. There seems to be a definite relationship between the clinical staging and ectopic hCG and hPL production. While hCG secretion is predominant in the later stages, hPL is produced in the earlier stages. It therefore seems that hPL might prove to be helpful in early diagnosis of carcinoma of the uterine cervix.
Extração da mucilagem em sementes de Genipa americana L. visando o potencial fisiológico

Belonging to the Rubiaceae family, the fruit-bearing plant, genipapo (G. americana L.), is widely distributed in humid tropical and subtropical regions of Latin America. The seeds present a thick adherent mucilage which can be harmful to germination, favouring the development of microorganisms; action is therefore needed for its removal. Given the above, the aim of this study was to evaluate the physiological potential of batches of genipapo seeds under different methods of extraction of this mucilage. Fruits of four genipapo mother plants from the town of Areia in the state of Paraiba, Brazil, were submitted to the following methods for the extraction of mucilage from the seeds: manual by sieve, running water and sand; fermentation; centrifugation and H2SO4. The physiological potential of the seeds was evaluated for water content, germination, first count and germination speed index, length and dry weight, seedling emergence and health test. The experimental design was completely randomised with mean values being compared by Tukey test (p<0.05). Seed moisture content was similar between batches. The different methods for extracting the mucilage from the genipapo seeds under evaluation did not affect germination, maintaining viability; when evaluated for vigour however, the seeds extracted by sieve were seen to be superior compared to the other methods. The method for the removal of mucilage from genipapo seeds using a sieve and sand gave seeds with high physiological potential, having no influence on the quality of health of those seeds.
Model-free detection and tracking of dynamic objects with 2D lidar

We present a new approach to detection and tracking of moving objects with a 2D laser scanner for autonomous driving applications. Objects are modelled with a set of rigidly attached sample points along their boundaries whose positions are initialized with and updated by raw laser measurements, thus allowing a non-parametric representation that is capable of representing objects independent of their classes and shapes. Detection and tracking of such object models are handled in a theoretically principled manner as a Bayes filter where the motion states and shape information of all objects are represented as a part of a joint state which includes in addition the pose of the sensor and geometry of the static part of the world. We derive the prediction and observation models for the evolution of the joint state, and describe how the knowledge of the static local background helps in identifying dynamic objects from static ones in a principled and straightforward way. Dealing with raw laser points poses a significant challenge to data association. We propose a hierarchical approach, and present a new variant of the well-known Joint Compatibility Branch and Bound algorithm to respect and take advantage of the constraints of the problem introduced through correlations between observations. Finally, we calibrate the system systematically on real world data containing 7,500 labelled object examples and validate on 6,000 test cases. We demonstrate its performance over an existing industry standard targeted at the same problem domain as well as a classical approach to model-free object tracking.
Actinomycosis: Diagnostic and therapeutic considerations and a review of 32 cases

Actinomycosis was at one time a common diagnosis in this country. It still is fairly common in some parts of the world. As the numbers of antibiotics and indications for their use have increased, the disease has almost become a medical rarity in the United States. This fact might be thought a paradox in view of the universal presence of the actinomyces organisms in every human mouth. However, it is perhaps not well recognized that the actinomyces are true bacteria, and that they are particularly sensitive to most of the common antibacterials in current usage. These facts have combined to decrease the clinical frequency of the disease as well as effectively reduce the opportunity for securing a satisfactory specimen for laboratory culture in suspected cases. Actinomycosis can present in a variety of forms and may mimic other infections or even neoplasms. The clinical pattern of remission and exacerbation of symptoms occurring in parallel sequence with initiation and cessation of antibiotic administration is a phenomenon which should increase suspicion for actinomycosis in any of its manifestations.
Evaluation of the effect of different enamel surface treatments and waiting times on the staining prevention after bleaching

Background Bleached dental enamel can be more susceptible to staining than the enamel that has never been bleached, especially right after tooth bleaching. The aim of this study is to evaluate the effect of surface treatments and waiting time prior to contact with dye on bleached enamel staining susceptibility. Material and Methods One hundred teeth were bleached with 35% hydrogen peroxide (Whiteness HP, FGM) and randomly assigned to G1 artificial saliva, G2 2% sodium fluoride (Flugel, Nova DFL), G3 casein phosphopeptide-amorphous calcium phosphate fluoride paste (CPP-ACPF, MI Paste Plus, GC America), G4 rinse for color maintenance after bleaching (Keep White Rinse, DMC) and G5 polishing with aluminum oxide-impregnated disks (Super Buff Disk, Shofu). Fifty specimens were immersed in red wine for 15 minutes, immediately after treatment, and the others one hour after. Color difference (∆E) was evaluated with a spectrophotometer (Vita EasyShade). Surface treatments and waiting time effects were analyzed with Kruskal-Wallis and Mann Whitney tests (p<0.05). Results Surface treatments (p>0.05) and waiting time (p>0.05) were not significant to decrease bleached enamel susceptibility to red wine staining. Conclusions Surface treatments were similar to artificial saliva for bleached enamel susceptibility to red wine staining. Immediate or one-hour-postponed contact with red wine did not affect bleached enamel color. Key words:Tooth bleaching, color, dental enamel, hydrogen peroxide, pigmentation.
The Anatomy of the CDS Market

Using novel position and trading data for single-name corporate credit default swaps (CDSs), we provide evidence that CDS markets emerge as "alternative trading venues" that serve a standardization and liquidity role. CDS positions and trading volume are larger for firms with bonds that are fragmented into many separate issues and have heterogeneous contractual terms. Whereas hedging motives are associated with trading volume in the bond and CDS markets, speculative trading concentrates in the CDS. Cross-market arbitrage links the CDS and bond market via the basis trade, impressing the negative CDS-bond basis and reducing price impact in the bond market.
XI. GENERAL DISCUSSION: CHILDREN'S ADJUSTMENT AND ADAPTATION FOLLOWING THE BIRTH OF A SIBLING.

There were three major aims to the work presented here. First, we examined individual differences in children’s adjustment after the birth of an infant sibling. By using information obtained from the Family Transitions Study, a longitudinal investigation with five timepoints (prenatal, 1, 4, 8 and 12 months), we explored the underlying trajectory patterns of change in children’s behavior problems over the course of a year. We expected distinct patterns of change in how children reacted to the birth. Second, because we wanted findings from this research to generate evidence-based recommendations for future intervention efforts or prebirth education classes, we utilized a series of data mining and confirmatory testing strategies that together took advantage of predictive validity and traditional hypothesis testing criteria to pinpoint pre-birth predictors of the different trajectory patterns. We also analyzed each of the seven behavioral syndromes of the CBCL--aggression, attention problems, anxious-depressed, emotional reactivity, withdrawal, somatic complaints, and sleep problems--separately because Dunn et al. (1981) claimed that a single assessment could not capture the variability in children’s problematic reactions seen after the birth of a sibling. As a result, we now have a better understanding of the risk and protective factors that predicted the severity of children’s emotional and behavioral problems and can discuss where to target interventions for the future. Finally, we examined whether children’s adjustment trajectories had repercussions for the developing sibling relationship at the end of the first year, knowing that there is considerable stability in the quality of children’s sibling relationships through childhood and adolescence. Making sure this relationship gets off to a good start not only alleviates parenting stress in the year after the birth, but has long-term developmental benefits for children (e.g., Buist & Vermande, 2014; Dunn et al., 1994).
What is the Optimal Treatment for Metastatic Colorectal Cancer? Controversial Points

Colorectal cancer (CRC) is the second leading cause of death from cancer in the developed countries. Although great efforts have been made to achieve an early diagnosis, a large number of cases will present metastases. The natural history of metastatic (m) CRC has dramatically evolved in the recent years thanks to the introduction of modern chemotherapy and molecular therapies. With these agents the response rate has increased to 50% and survival has been improved not only progression free survival (PFS), which has reached 12 months, but also overall survival (OS) which is longer than 2 years. Despite this progress many questions remain to be answered, mainly those related to the sequential regimens, drug rotation, alternant or intermitent schedules, optimal duration of chemotherapy, the role of maintenance chemotherapy and the role of doublets or triplets. The optimal duration of chemotherapy is very important because it has a direct influence on the patient quality of life, survival and costs. There are several studies addressing this topic and the alternatives we have, such as “stop and go”, intermittent strategies or maintenance of only several agents and these studies reinforce the frequent behaviour of the oncologists to stop the treatment when the patient has obtained the maximum response. But there are some methodological problems in the analyzed trials which have determined that not all the professionals agree with this proposal. With this context it is essential to perform well designed clinical trials incorporating new drugs and addressing these questions. This article tries to review briefly all these controversial points.
Vitamin D deficiency causes deficits in lung function and alters lung structure.

RATIONALE The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease. Recent studies suggest that vitamin D deficiency is associated with reduced lung function. The relationship between vitamin D deficiency and lung function is confounded by the association between physical activity levels and vitamin D status. Thus, causal data confirming a relationship between vitamin D and lung function are lacking. OBJECTIVES To determine if vitamin D deficiency alters lung structure and function. METHODS A physiologically relevant BALB/c mouse model of vitamin D deficiency was developed by dietary manipulation. Offspring from deficient and replete colonies of mice were studied for somatic growth, lung function, and lung structure at 2 weeks of age. MEASUREMENTS AND MAIN RESULTS Lung volume and function were measured by plethysmography and the forced oscillation technique, respectively. Lung structure was assessed histologically. Vitamin D deficiency did not alter somatic growth but decreased lung volume. There were corresponding deficits in lung function that could not be entirely explained by lung volume. The volume dependence of lung mechanics was altered by deficiency suggesting altered tissue structure. However, the primary histologic difference between groups was lung size rather than an alteration in architecture. CONCLUSIONS Vitamin D deficiency causes deficits in lung function that are primarily explained by differences in lung volume. This study is the first to provide direct mechanistic evidence linking vitamin D deficiency and lung development, which may explain the association between obstructive lung disease and vitamin D status.
Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis.

PURPOSE Bacterial keratitis is a sight-threatening infection of the cornea that is one of the leading causes of blindness globally. In this report, we analyze the role of moxifloxacin susceptibility in the relationship between causative organisms and clinical outcome in bacteria keratitis. METHODS A mediation analysis is used to assess the role of moxifloxacin susceptibility in the relationship between causative organisms and clinical outcome in bacterial keratitis using data collected in a randomized, controlled trial. RESULTS In the Steroids for Corneal Ulcers Trial (SCUT), 500 corneal infections were treated with topical moxifloxacin. The outcome of 3-week best spectacle-corrected visual acuity was significantly associated with an organism (Streptococcus pneumoniae, Pseudomonas aeruginosa, etc., P = 0.008). An indirect effects mediation model suggests that MIC accounted for approximately 13% (95% confidence interval, 3%-24%, P = 0.015) of the effect of the organism on 3-week visual acuity. CONCLUSIONS Moxifloxacin mediates the relationship between causative organisms and clinical outcome in bacterial keratitis, and is likely on the causal pathway between the organism and outcome. (ClinicalTrials.gov number, NCT00324168.).
Management of obstructive sleep apnea: Comparison of various treatment modalities

From July, 1982 through March, 1986, 253 patients with moderate to severe sleep apnea (OSA) were treated and had polysomnographic assessment of treatment. The treatment modalities were: 1. uvulopalatopharyngoplasty (UPP), 2. nasal continuous positive airway pressure (CPAP), 3. tracheostomy, 4. medication (tricyclic antidepressants), 5. tongue retaining device (TRD), and 6. orthodontic device.
Recent advances and controversies in surgical management of liver diseases: summary of liver sessions of 7th World Congress of IHPBA 2006.

Over the past few years, there has been significant progress in the surgical management of various liver diseases as a result of advances in surgical technologies and the effort of liver surgeons around the world to improve the treatment outcome of their patients through active research. However, partly because of the paucity of high-level evidence in the literature, there are still a lot of controversies in several areas in liver surgery. The programme of the 7th World Congress of the International Hepato-pancreato-biliary Association held in Edinburgh on 3–7 September 2006 has incorporated most of the recent advances and controversies in liver surgery. The main topics presented and discussed in various keynote lectures, symposia, and free paper sessions of the Congress can be summarized into five areas: advances in surgical techniques of liver resection, role of ablative therapies, applications of liver transplantation, recent trends in management of colorectal liver metastasis, and controversies in management of hepatocellular carcinoma (HCC).
Quantitative Chromatographic Analysis of the Phospholipids of Abnormal Human Red Blood Cells.∗

Summary The red blood cell phospholipids were analyzed in patients with hereditary spherocytosis, pernicious anemia, sprue, intermediate thalassemia, sickle cell anemia, and polycythemia vera using chromatography on silicic acid columns. The total lipid phosphorus concentration was increased in the patients with intermediate thalassemia and sickle cell anemia and may have been slightly decreased in the patients with pernicious anemia and sprue. No consistent difference from normal in distribution of the individual phospholipid fractions was found. Variations in the absolute concentrations of the individual phospholipid fractions reflected differences in the total red blood cell lipid phosphorus concentrations. ADDENDUM. The red blood cells of a 56-year-old lady with paroxysmal nocturnal hemoglobinuria were analyzed and found to contain 4.14 mmoles/l lipid phosphorus with a phospholipid distribution as follows: “cephalin”—44.4%; lecithin—34.1%; sphingomyelin—20.0%; and lysolecithin 1.5%.
Performance-Driven Architectural Synthesis for Distributed Register-File Microarchitecture with Inter-Island Delay

SUMMARY In deep-submicron era, wire delay is becoming a bottle-neck while pursuing higher system clock speed. Several distributed register (DR) architectures are proposed to cope with this problem by keeping most wires local. In this article, we propose the distributed register-ﬁle microarchitecture with inter-island delay (DRFM-IID). Though DRFM-IID is also one of the DR-based architectures, it is considered more practical than the previously proposed DRFM, in terms of delay model. With such delay consideration, the synthesis task is inherently more complicated than the one without inter-island delay concern since uncertain interconnect latency is very likely to seriously impact on the whole system performance. Therefore we also develop a performance-driven architectural synthesis framework targeting DRFM-IID. Several factors for evaluating the quality of re-sults, such as number of inter-island transfers, timing-criticality of transfer, and resource utilization balancing, are adopted as the guidance while performing architectural synthesis for better optimization outcomes. The experimental results show that the latency and the number of inter-cluster transfers can be reduced by 26.9% and 37.5% on average; and the latter is commonly regarded as an indicator for power consumption of on-chip
MICROPERIMETRIC ASSESSMENT OF RETINAL SENSITIVITY IN EYES WITH DIABETIC MACULAR EDEMA FROM A PHASE 2 STUDY OF INTRAVITREAL AFLIBERCEPT

Purpose: To evaluate retinal sensitivity in patients with diabetic macular edema who received intravitreal aflibercept injection (IAI) or laser. Methods: A substudy included 46 patients from DA VINCI (a randomized, double-masked Phase 2 study) receiving either laser, 0.5 mg IAI every 4 weeks, 2 mg IAI every 4 weeks, 2 mg IAI every 8 weeks after 3 monthly doses (2q8), or 2 mg IAI as-needed after 3 monthly doses for 52 weeks. Retinal sensitivity was measured in one (central), five (one central and four inner), and eight (four inner and four outer) optical coherence tomography subfields. Results: Mean best-corrected visual acuity improvement in the subgroup at Week 52 was 3.3 letters with laser and ranged from 5.4 to 16.3 letters in the IAI groups. Retinal sensitivity of laser patients at Week 52 was comparable with baseline in the central optical coherence tomography subfield but decreased in the five and eight optical coherence tomography subfields. Compared with laser, retinal sensitivity significantly increased with IAI in the 2q8 and pooled IAI groups in the 5 and 8 optical coherence tomography subfields at Week 52 (P < 0.05). Conclusion: Intravitreal aflibercept injection improved best-corrected visual acuity and retinal sensitivity in this subgroup of patients. Laser may cause a deterioration of macular function that is not detectable with best-corrected visual acuity testing.
Impact of child maltreatment and interadult violence on children's emotion regulation abilities and socioemotional adjustment.

The present investigation sought to examine the unique and interactive effects of child maltreatment and interadult violence on children's developing strategies of emotion regulation and socioemotional adjustment, as well as the mediational role of emotion dysregulation in the link between children's pathogenic relational experiences and behavioral outcomes. Person-oriented emotion regulation patterns (EMRPs) were determined based on children's emotional behavioral and self-reported responses to simulated interadult anger. One hundred thirty-nine 4- to 6-year-olds (88 maltreated, 51 nonmaltreated) and their mothers served as participants. Maltreatment history predicted children's EMRPs, with approximately 80% of the maltreated preschoolers exhibiting dysregulated emotion patterns (i.e., undercontrolled/ambivalent and overcontrolled/unresponsive types) compared with only 37.2% of the nonmaltreated controls. Undercontrolled/ambivalent EMRPs were associated with maternal reports of child behavior problems, and were found to mediate the link between maltreatment and children's anxious/depressed symptoms. The present study's findings increase understanding of process relations in pathogenic relational environments, and provide insight into emotion regulation deficits that may impede the development of psychological well-being in maltreated children with varying histories of interadult violence exposure.
Do prostaglandins have a salutary role in skeletal muscle ischaemia-reperfusion injury?

OBJECTIVES the effects of prostaglandins (PG) E1, E2, and the prostacyclin analogue iloprost with and without the addition of free-radical scavengers catalase and superoxide dismutase on gastrocnemius blood flow and oedema were studied in a rodent model of hindlimb ischaemia-reperfusion. METHODS male Sprague-Dawley rats underwent 6-h hindlimb ischaemia with 4-h reperfusion. Prostaglandins were infused prior to reperfusion and their effects on limb blood flow and oedema examined. RESULTS control animals exhibited a triphasic pattern of muscle blood flow during reperfusion compared to normal animals. PGE1 did not abolish low reflow at 10 min, relative reperfusion was preserved but reperfusion injury was abolished at 120 min. Muscle blood flow was increased at 240 min compared to controls. Increased limb swelling was also seen. Addition of free-radical scavengers caused the abolition of low reflow. Similar results were seen with iloprost. PGE2 abolished low reflow at 10 min and increased perfusion at 120 min but did not prevent reperfusion injury at 240 min. CONCLUSIONS PGE1 and iloprost enhance muscle blood flow at 4-h reperfusion, though neither abolishes low reflow; PGE2 improved flow at 10 and 120 min but not after 240 min. This study demonstrates a potentially beneficial role for prostaglandins in improving muscle blood flow in skeletal muscle ischaemia-reperfusion injury.
Metrics for Managing Online Procurement Auctions

Metrics can improve firms' ability to manage online procurement auctions. A key factor in business-to-business procurement auctions is supplier participation, which we modeled as a multistage process. We analyzed data collected from thousands of auctions conducted by a large multinational firm and found that different auction types lead to different participation and success dynamics. Typically, it is important to invite a sufficient number of suppliers and ensure that they accept the invitation and actually log into the auction. It is even more important to encourage active bidding and reduce the proportion of suppliers who log in but never bid.