Miracle-dz/UniFAR-FTUs huggingface dataset:
Post‐pubertal emergence of alterations in locomotor activity in stop null mice

Overt schizophrenia is preceded by a prodromal phase during which juvenile patients display attenuated schizophrenia‐related symptoms. Here, we have looked for evidence of a prodromal phase in juvenile STOP null mice, which, during adulthood, imitate features of schizophrenia. We have principally examined locomotor activity, which is abnormal in adult STOP null mice, and its apparent relationship with perturbed glutamatergic and dopaminergic transmission. When compared to corresponding wild‐type mice, juvenile STOP null mice did not exhibit the basal hyperlocomotion or locomotor hypersensitivity to mild stress observed in adult mice. Juvenile STOP null mice also lacked disturbed locomotor sensitivity to MK‐801, which was evident in adult mice. In contrast, juvenile STOP null mice exhibited a similar hypersensitivity to amphetamine as that found in adult mice. Thus, STOP null mice exhibited both a progression of locomotor activity defects over time and subtle alterations in the prepubertal period. We suggest that the pattern of locomotor disturbances observed in this study is related to altered dopaminergic reactivity in juvenile mice without major disturbance in glutamatergic transmission, whereas both neurotransmitter systems are impaired in adult mice. Synapse 61:689–697, 2007. © 2007 Wiley‐Liss, Inc.
InterShop: Enhancing the Vendor/Customer Dialectic in Electronic Shopping

Electronic shopping systems offer new horizons in vendor marketing, customer convenience, and overall market efficiencies. Information networks can gather thousands of vendors and millions of customers into an information-rich marketplace that serves both their perspectives. Unfortunately, existing electronic shopping systems provide a vendor/customer dialectic that offers low product differentiation and comparability. This limits market efficiency and results in negative experiences for both vendors and customers. We propose a functional architecture for a new generation of electronic shopping infrastructures to dramatically improve vendor representation and customer navigation. This design reshapes the vendor/customer dialectic by providing higher levels of both product differentiation and comparability. A prototype implementation of the architecture is described.
Migration and Cognitive Representations of Hypertension in African Immigrant Women

The purpose of this study was to use the Self-Regulation Model on African immigrant women, to determine the association of migration and residence in the United States with cognitive representations and dietary behavior, and also to explore migration stress and blood pressure (BP) in them. Participants included a convenience sample of 91 Nigerian immigrant women (NIW) and 38 African American women (AAW). Data collection instruments were the Acculturative Stress Scale and the Women’s and Men’s Hypertension Experiences and Emerging Lifestyle Survey of 2008-2009. Descriptive t test and ANOVA statistics were used to analyze study variables comparing groups and NIW duration of residency in the United States. Knowledge of Hypertension and Cognitive Representation of Hypertension were significantly increased in the NIW by years of residency. Migration stress had no significant relationship with BP level. A longitudinal study initiated on immigrants’ arrival in the United States is recommended to understand the trajectory of chronic illnesses such as hypertension.
Human Endometrial Mucin MUC1 Is Up-Regulated by Progesterone and Down-Regulated In Vitro by the Human Blastocyst1

Abstract Expression of MUC1 in endometrial epithelium has been suggested to create a barrier to embryo attachment that must be lifted at the time of implantation. In this study, we investigated the hormonal regulation of human endometrial MUC1 in hormone replacement therapy cycles and in the human blastocyst. We also analyzed the embryonic regulation of MUC1 in human endometrial epithelial cells (EECs) during the apposition and adhesion phases of human implantation using two different in vitro models. Our results indicate that endometrial MUC1 mRNA and immunoreactive protein increase in receptive endometrium compared to nonreceptive endometrium. Human blastocysts express MUC1, as demonstrated by reverse transcription-polymerase chain reaction and immunocytochemistry, localized at the trophectoderm. In vitro, MUC1 was present at the surface of primary cultures of human EEC, and presence of a human blastocyst (i.e., apposition phase) increases EEC MUC1 protein and mRNA compared to control EEC lacking embryos. Interestingly, when human blastocysts were allowed to attach to the EEC monolayer (i.e., adhesion phase), MUC1 was locally removed in a paracrine fashion on EEC at the implantation site. These results demonstrate a coordinated hormonal and embryonic regulation of EEC MUC1. Progesterone combined with estradiol priming induces an up-regulation of MUC1 at the receptive endometrium. During the apposition phase, presence of a human embryo increases EEC MUC1. However, at the adhesion phase, the embryo induces a paracrine cleavage of EEC MUC1 at the implantation site. These findings strongly suggest that MUC1 may act as an endometrial antiadhesive molecule that must be locally removed by the human blastocyst during the adhesion phase.
Vascular Mild Cognitive Impairment Is Highly Prevalent after Lacunar Stroke but Does Not Increase over Time: A 2-Year Follow-Up Study

Although ample research has been done into cognitive disorders occurring after stroke, relatively few data are available on the development and the course of vascularmild cognitive impairment (VMCI) after first-ever lacunar stroke. Methods: A cohort of 95 patients with a first-ever symptomaticlacunar infarct, older than 40 years, MMSE ≧15 and no other neurological or major psychiatric deficits were included. Patients were assessed (clinically and with a neuropsychological test battery) at 1 and 24 months after stroke, and CT was repeated. VMCI was diagnosed when patients had a deficit in at least one cognitive domain, in the absence of dementia. Results: Approximately 75% of the patients had VMCI at 1 month; this percentage was somewhat lower at 2 years. Only initial stroke severity was an independent predictor of VMCI after stroke. Conclusion: VMCI is highly prevalent after lacunar stroke, but does not increase during the first 2 years thereafter.
Rural Settlement Subdivision by Using Landscape Metrics as Spatial Contextual Information

Multiple policy projects have changed land use and land cover (LULC) in China’s rural regions over the past years, resulting in two types of rural settlements: new-fashioned and old-fashioned. Precise extraction of and discrimination between these two settlement types are vital for sustainable land use development. It is difficult to identify these two types via remote sensing images due to their similarities in spectrum, texture, and geometry. This study attempts to discriminate different types of rural settlements by using a spatial contextual information extraction method based on Gaofen 2 (GF-2) images, which integrate hierarchical multi-scale segmentation and landscape analysis. A preliminary LULC map was derived by using only traditional spectral and geometrical features from a finer scale. Subsequently, a vertical connection was built between superobjects and subobjects, and landscape metrics were computed. The vertical connection was used for assigning landscape contextual information to subobjects. Finally, a classification phase was conducted, in which only multi-scale contextual information was adopted, to discriminate between new-fashioned and old-fashioned rural settlements. Compared with previous studies on multi-scale contextual information, this paper employs landscape metrics to quantify contextual characteristics, rather than traditional spectral, textural, and topological relationship information, from superobjects. Our findings indicate that this approach effectively identified and discriminated two types of rural settlements, with accuracies over 80% for both producers and users. A comparison with a conventional top-down hierarchical classification scheme showed that this novel approach improved accuracy, precision, and recall. Our results confirm that multi-scale contextual information with landscape metrics provides valuable spatial information for classification, and indicates the practicability, applicability, and effectiveness of this synthesized approach in distinguishing different types of rural settlements.
Heavy-Traffic Limits for Queues with Many Exponential Servers

Two different kinds of heavy-traffic limit theorems have been proved for s -server queues. The first kind involves a sequence of queueing systems having a fixed number of servers with an associated sequence of traffic intensities that converges to the critical value of one from below. The second kind, which is often not thought of as heavy traffic, involves a sequence of queueing systems in which the associated sequences of arrival rates and numbers of servers go to infinity while the service time distributions and the traffic intensities remain fixed, with the traffic intensities being less than the critical value of one. In each case the sequence of random variables depicting the steady-state number of customers waiting or being served diverges to infinity but converges to a nondegenerate limit after appropriate normalization. However, in an important respect neither procedure adequately represents a typical queueing system in practice because in the (heavy-traffic) limit an arriving customer is either almost certain to be delayed (first procedure) or almost certain not to be delayed (second procedure). Hence, we consider a sequence of ( GI / M / S ) systems in which the traffic intensities converge to one from below, the arrival rates and the numbers of servers go to infinity, but the steady-state probabilities that all servers are busy are held fixed. The limits in this case are hybrids of the limits in the other two cases. Numerical comparisons indicate that the resulting approximation is better than the earlier ones for many-server systems operating at typically encountered loads.
Onset of Otitis Media in the First Eight Weeks of Life in Aboriginal and Non-Aboriginal Australian Infants

Otitis media (OM) is highly prevalent among Aboriginal Australians, in whom eardrum perforations with discharge have been reported in the first 3 months of life. Only one published study, however, has described middle ear status at birth or prior to eardrum perforation in young Aboriginal infants. This prospective study used otoscopy, tympanometry, and hearing tests to compare middle ear status and hearing sensitivity in Aboriginal and non-Aboriginal neonates. Immobile eardrums were observed immediately after birth, but mobility generally appeared within the first week. At examinations at 6 to 8 weeks of age, OM with effusion or acute OM was observed in 95% of 22 Aboriginal infants, but OM with effusion was seen in only 30% of 10 non-Aboriginal infants. There was a clinic record of unilateral perforation in 1 Aboriginal infant only. Hearing impairment was demonstrated by auditory brain stem response in 5 ears, all with evidence of middle ear abnormalities. Improved knowledge and diagnosis of the signs and symptoms of OM will contribute to improvements in the provision of early medical intervention to populations at high risk for early OM.
Abdominal diameters as indicators of visceral fat: comparison between magnetic resonance imaging and anthropometry

The aim of the present study was to investigate the usefulness of abdominal diameters to indicate visceral fat, their relationship with serum lipids and their capability of detecting changes in visceral fat. Before and after weight loss, visceral and subcutaneous fat, and the sagittal and transverse diameters were assessed by magnetic resonance imaging (MRI) in forty-seven obese men and forty-seven premenopausal obese women with an initial body mass index of 31·0 (SD 2·4) kg/m2. In a subsample (n 21), diameters, were also measured by anthropometry in the standing and supine positions. They were strongly correlated with the diameters derived from the MRI scans. Serum levels of total and HDL-cholesterol and triacylglycerol were measured before weight loss. In women the sagittal diameter correlated less strongly with visceral fat than anthropometrically-assessed waist circumference and waist:hip ratio (WHR). In men these associations were comparable. Changes in visceral fat with weight loss were more strongly correlated with changes in the sagittal diameter and sagittal:transverse diameter ratio (STR) than with changes in waist circumference or WHR in men. In women, changes in the anthropometric variables and the separate diameters (except STR) were not associated with visceral fat loss. In men, but not in women, both the sagittal diameter and the visceral fat area were related to serum lipids. It is concluded that the sagittal diameter and STR may have advantages over waist circumference and WHR in men, particularly in assessing changes in visceral fat, but this could not be demonstrated in women. The ability to predict visceral fat from circumferences and diameters or their ratios is, however, limited in obese men and women.
Regulation and frequency response service capability of modern wind power plants

Wind speed variability generates the main challenges for grid integration of wind power. Worldwide, requirements governing generator connection to the transmission grid evolve as the modern energy industry continues to develop. With increased wind power penetration, wind power plants are required to provide grid support and control actions similar to conventional power plants. Dedicated control systems for wind power plants employing variable-speed wind turbines can provide advanced control features for the transmission network operator. The paper summarizes the control characteristics of a modern wind power plant. It identifies the capability of modern wind power plants to offer fast regulation and frequency response services. Advanced functionalities for regulation and response to grid disturbances are also addressed.
Prognostic significance of CXCL12, CXCR4, and CXCR7 in patients with breast cancer.

BACKGROUND The chemokine CXCL12 and its receptors CXCR4 and CXCR7 play important roles in cancer invasion and metastasis. This study investigated the mRNA expressions of CXCL12, CXCR4, and CXCR7 to illustrate the role of these biomarkers in breast cancer metastasis and prognosis. METHODS The mRNA expressions of CXCL12, CXCR4, and CXCR7 in 115 primary breast cancer and regional lymph node specimens were detected by quantitative reverse-transcription polymerase chain reaction. Survival time was analyzed by Kaplan-Meier survival curves using log-rank test. Univariable and multivariable Cox regression analyses were performed to assess independent prognostic factors for survival. RESULTS The expression levels of CXCR4 and CXCR7 in breast cancer tissues were significantly higher than that in adjacent normal tissues (P=0.022 and P<0.001, respectively), while the expression level of CXCL12 in breast cancer tissues did not differ from that in adjacent normal tissues (P=0.156). Furthermore, CXCL12 exhibited significant differences in expression between primary tumor and lymph node metastasis tumor (P=0.039). CXCR4 and CXCR7 expressions in metastasis tumor were also higher, although no significant difference was observed (P=0.067 and P=0.054, respectively). Kaplan-Meier survival analysis revealed that patients exhibiting high CXCR4 and CXCR7 expression experienced a shorter survival period compared with those with low expression. When analyzed with a Cox regression model, the expressions of CXCL12, CXCR4 and CXCR7 were independent prognostic factors for overall survival. CONCLUSIONS The mRNA expressions of CXCL12, CXCR4, and CXCR7 play important roles in the progression and metastasis of breast cancer and may act as predictive factors significantly affecting the prognosis.
Role of alpha-toxin in Clostridium perfringens infection determined by using recombinants of C. perfringens and Bacillus subtilis

Clostridium perfringens type A strains which differed in alpha-toxin (phospholipase C [PLC]) productivity were inoculated intraperitoneally or intravenously into mice, and then their 50% mouse lethal doses (LD50) were determined. Strain NCTC 8237 produced ninefold higher PLC activity than strain 13. The mean LD50 for the former was 1 log unit lower than that for the latter. Two isogenic strains were constructed from strain 13: strain 13(pJIR418 alpha) (pJIR418 alpha contains the plc gene), which produced ninefold higher PLC activity than strain 13; and strain 13 PLC-, which showed no PLC productivity at all because of transformation-mediated gene disruption. The mean LD50 for strain 13(pJIR418 alpha) was 1 log unit lower than those for strain 13 PLC- and strain 13. These results indicate that PLC functions as a virulence-determining factor when it is produced in a sufficient amount. Such a difference in LD50 was also observed between Bacillus subtilis with and without the cloned plc gene. Inoculation of B. subtilis PLC+ intravenously into mice caused marked thrombocytopenia and leukocytosis. Mice inoculated with B. subtilis at 2 LD50 died because of circulatory collapse. Histological examination revealed that intravascular coagulation and vascular congestion occurred most prominently in the lungs. These results suggest that PLC plays a key role in the systemic intoxication of clostridial myonecrosis, probably by affecting the functions of platelets and phagocytes.
A Three-Dimensional Particle-in-Cell Simulation of Quasi-Perpendicular Shock on Fujitsu FX1 Cluster

The high-specification computational power of Japan Aerospace Exploration Agency's new supercomputer system, called Fujitsu FX1 cluster, enables us to perform really macroscale 3-D situations with full particle plasma simulation [particle-in-cell (PIC) method]. A fully 3-D kinetic approach to collisionless shock problems, which is one of the most important problems in the space plasma science, is possible, and a challenging run is being executed for a pioneering study of the topic. About 0.4 billion grids are allocated for the electromagnetic fields, and about 0.1 trillion particles are loaded into the simulation run. The computational efficiency of the PIC code is about 8% of the peak performance (4.6 Tflops) using 5776 CPU cores (57 Tflops). The simulation parameters were selected to simulate ESA's Cluster-II spacecraft observational result reported by Seki (in 2009). The full mass ratio mi/me = 1840 was taken for this simulation, and almost one ion inertia length square could be allocated for the simulation. In this simulation, a quite complicated wave activity is found in the shock foot region. In this paper, comparing 3-D results with 2-D simulation results, a 3-D nature of shock transition region of quasi-perpendicular shock is reported.
International travelers and unintentional fatal drowning in Australia--a 10 year review 2002-12.

INTRODUCTION . Drowning deaths of travelers are commonly reported in the media, creating a perception that they are at a higher risk of drowning than residents. This may be true, due in part to unfamiliarity with the risks posed by the hazard, however there is limited information about drowning deaths of travelers in Australia. This study aims to identify the incidence of drowning among international travelers in Australia and examine the risk factors to inform prevention strategies. METHODS . Data on unintentional fatal drowning in Australian waterways of victims with a residential postcode from outside Australia were extracted from the Royal Life Saving Society-Australia National Fatal Drowning Database. RESULTS . Between 1 July 2002 and 30 June 2012 drowning deaths among people known to be international travelers accounted for 4.3% (N = 123) of the 2870 drowning deaths reported in Australian waterways. Key locations for drowning deaths included beaches (39.0%), ocean/harbour (22.0%) and swimming pools (12.2%). Leading activities prior to drowning included swimming (52.0%), diving (17.9%) and watercraft incidents (13.0%). DISCUSSION . International travelers pose a unique challenge from a drowning prevention perspective. The ability to exchange information on water safety is complicated due to potential language barriers, possible differences in swimming ability, different attitudes to safety in the traveler's home country and culture, a lack of opportunities to discuss safety, a relaxed attitude to safety which may result in an increase in risk taking behaviour and alcohol consumption. CONCLUSION . Prevention is vital both to reduce loss of life in the aquatic environment and promote Australia as a safe and enjoyable holiday destination for international travelers.
GipA Factor Supports Colonization of Peyer's Patches by Crohn's Disease-associated Escherichia Coli

Background:Adherent-invasive Escherichia coli (AIEC) associated with Crohn's disease target M cells lining Peyer's patches (PPs) through the expression of long polar fimbriae (LPF) and survive macrophage killing. Invasion of PPs constitutes a way to colonize the mucosa for bacteria able to escape or resist killing of underlying immune cells. We aimed to identify new virulence factors involved in PPs colonization by AIEC. Methods:The presence of gipA (Growth in PPs) gene was determined by polymerase chain reaction. In vivo experiments were performed using CEABAC10 transgenic mice. Intramacrophagic behavior of AIEC was assessed in murine bone marrow-derived macrophages and human monocyte-derived macrophages. Cytokines production was quantified by ELISA. Results:A higher prevalence of gipA-positive E. coli was observed in patients with Crohn's disease (27.3%) compared with controls (17.2%). Unlike non-AIEC strains, all gipA-positive AIEC strains also harbored lpfA. GipA deletion impaired AIEC translocation across M cells and their replication inside macrophages. GipA expression was induced by gastrointestinal (bile salts) and phagolysosomal (reactive oxygen species and acid pH) conditions. GipA deletion decreased lpfA mRNA level in AIEC bacteria. Survival of AIEC-&Dgr;gipA bacteria was reduced in medium containing H2O2 or acidic pH. GipA deletion impaired AIEC colonization of PPs and dissemination to mesenteric lymph nodes in mice. Conclusions:GipA is required for optimal colonization of mouse PPs and survival within macrophages by AIEC, suggesting that this factor plays a role in AIEC promotion of Crohn's disease. Detection of gipA and lpfA could be a predictor for the presence of AIEC.
Properties of Thermus ruber Strains Isolated from Icelandic Hot Springs and DNA:DNA Homology of Thermus ruber and Thermus aquaticus

Seventeen pink-pigmented strains of the genus Thermus were isolated from samples collected from thermal areas of Iceland. The strains were examined by using phenotypic characterization and DNA:DNA homology and were compared with recognized strains. Visually, the strains could be divided into three groups based on their pigmentation; however, spectroscopic studies of the pigments indicated little difference among them. Most strains required a vitamin supplement for growth and used fructose, maltose, mannose, or sucrose as the sole carbon source. In the presence of nitrate, two strains were able to grow under anaerobic conditions. The optimum growth temperature was 60°C; growth did not occur at 30 or 70°C.