Miracle-dz/UniFAR-FTUs huggingface dataset:
Central and Peripheral Venous Port Catheters: Evaluation of Patients' Satisfaction under Local Anesthesia

statistically significant (Tab. I). Using the Visual Analogical Scale, overall satisfaction was found to be quite high but lower than in the study by Maurer et al. There was no statistical difference between the two study groups, namely, chest port versus arm port (7.8 vs 7.99). Interestingly, the insertion procedure was less painful in API patients. Patients experienced a “foreign body perception” more frequently with their port placed on the chest (72.2% vs 56.5%). Furthermore, the chest port device more frequently induced bra inconvenience (particularly in female patients over 60 (p=0.02)) and discomfort when wearing a safety belt or a bag with a strap. Shoulder bag discomfort was felt to be more important in female patients than in male patients (p=0.03). Sixteen percent of chest port patients felt that the device accessibility was difficult versus only 3.2% of arm port patients (p<0.05). Nevertheless, during drug infusion, CVC port patients felt more comfortable than API patients (47.2% vs 30.10%), most probably because of a higher mobility of the arm compared to the chest and a lower stability of the implanted Huber needle. Nurses were also given a questionnaire. They found that the chest port device was more stable, easier to puncture, especially in a sitting patient, compared to the arm port device. The cosmetic appearance and discretion of the device were found to be similar in the two groups. Finally, API was a little less painful and had an overall higher insertion success rate than CVC but was found to be less stable. Considering the non-statistically-significant difference of the EORTC QLQC-30 results between the two patient groups, we advocate for a more specific questionnaire in order to assess the QOL in patients needing venous port catheters. Central and peripheral venous port catheters: evaluation of patients’ satisfaction under local anesthesia
Psychological health among Chinese college students: a rural/urban comparison

The literature on suicide among the Chinese indicates that younger individuals from rural areas are at higher risk of suicide than their urban counterparts. While earlier studies have investigated the relationship between psychological health and major demographic variables, the relationship of psychological health as it relates to suicide by those from urban and rural areas have been rare. Studying the psychological health of college students from rural China in comparison with students who originate from urban areas may shed light on the mental health disparities of the two populations. This study examined the relationship of psychological health and rural/urban origins of college students in China. Data was obtained from 2 400 college students who completed a survey questionnaire while in attendance at a key university in Beijing China in 2013. Four standardised psychological health scales were administered to obtain measures of participants’ self-esteem, depression, social support, and suicide ideation. Findings indicated that urban students had significantly higher scores than their rural counterparts on self-esteem and social support. However, there was no statistically significant difference between the groups on measures of depression and suicide ideation.
Fermentation of Tomato Juice by Cell Immobilized Lacto bacillus acidophilus

Purpose. Ca-alginate entrapped Lacto bacillus acidophilus was used to ferment tomato juice and enhance the survival of the bacteria in the product. Method. L acidophilus was immobilized in gel beads with diameters of about 2.6 mm. Tomato juice was made from fresh raw tomatoes, followed by fermentation for 80 h with free and immobilized cells. Results. Immobilized cells leaked from the gel beads and proliferated in the juice during the fermentation; the final viable cell number reached 10^7 CFU/mL in the juice and above 10^10 CFU/mL-gel in gel beads. Free cells reached about 10^9 CFU/mL during fermentation. Immobilized cells endured the adverse conditions in tomato juice; furthermore, viable cell numbers and sensory score results were higher compared with free cells. The viable cell counts of immobilized L. acidophilus were maintained at 10^7 CFU/mL-gel in the fermented tomato juice after 10 weeks of cold storage at 4℃, compared with 10^4 CFU/mL of free cells. Conclusions. Ca-alginate immobilized L acidophilus enhanced the viable cell number and improved the sensory quality of fermented tomato juice. Our findings could be applied to the development of probiotic tomato juice.
Peripheral in fl ammatory hyperalgesia depends on the COX increase in the dorsal root ganglion

It is well established that dorsal root ganglion (DRG) cells synthesize prostaglandin. However, the role that prostaglandin plays in the inflammatory hyperalgesia of peripheral tissue has not been established. Recently, we have successfully established a technique to inject drugs (3 μL) directly into the L5-DRG of rats, allowing in vivo identification of the role that DRG cell-derived COX-1 and COX-2 play in the development of inflammatory hyperalgesia of peripheral tissue. IL-1β (0.5 pg) or carrageenan (100 ng) was administered in the L5-peripheral field of rat hindpaw and mechanical hyperalgesia was evaluated after 3 h. Administration of a nonselective COX inhibitor (indomethacin), selective COX-1 (valeryl salicylate), or selective COX-2 (SC-236) inhibitors into the L5-DRG prevented the hyperalgesia induced by IL-1β. Similarly, oligodeoxynucleotide-antisense against COX-1 or COX-2, but not oligodeoxynucleotide-mismatch, decreased their respective expressions in the L5-DRG and prevented the hyperalgesia induced by IL-1β in the hindpaw. Immunofluorescence analysis demonstrated that the amount of COX-1 and COX-2, constitutively expressed in TRPV-1 cells of the DRG, significantly increased after carrageenan or IL-1β administration. In addition, indomethacin administered into the L5-DRG prevented the increase of PKCe expression in DRG membrane cells induced by carrageenan. Finally, the administration of EP1/EP2 (7.5 ng) or EP4 (10 μg) receptor antagonists into L5-DRG prevented the hyperalgesia induced by IL-1β in the hindpaw. In conclusion, the results of this study suggest that the inflammatory hyperalgesia in peripheral tissue depends on activation of COX-1 and COX-2 in C-fibers, which contribute to the induction and maintenance of sensitization of primary sensory neurons.
A Queueing System with Heterogeneous Impatient Customers and Consumable Additional Items

Abstract A single-server queueing system with a marked Markovian arrival process of heterogeneous customers is considered. Type-1 customers have limited preemptive priority over type-2 customers. There is an infinite buffer for type-2 customers and no buffer for type-1 customers. There is also a finite buffer (stock) for consumable additional items (semi-products, half-stocks, etc.) which arrive according to the Markovian arrival process. Service of a customer requires a fixed number of consumable additional items depending on the type of the customer. The service time has a phase-type distribution depending on the type of the customer. Customers in the buffer are impatient and may leave the system without service after an exponentially distributed amount of waiting time. Aiming to minimize the loss probability of type-1 customers and maximize throughput of the system, a threshold strategy of admission to service of type-2 customers is offered. Service of type-2 customer can start only if the server is idle and the number of consumable additional items in the stock exceeds the fixed threshold. Stationary distributions of the system states and the waiting time are computed. In the numerical example, we show some interesting effects and illustrate a possibility of application of the presented results for solution of optimization problems.
Nebulized epinephrine for young children with bronchiolitis.

QUESTION Every winter I see infants with flulike symptoms and wheezing. I frequently diagnose them with bronchiolitis based on their presenting symptoms. Would it be prudent to send those infants to the nearest emergency department for treatment with nebulized epinephrine? ANSWER Nebulized epinephrine should not be routinely used in infants with bronchiolitis. It is an option to consider in those with severe symptoms. If it is given and there are no signs of improvement, further doses are discouraged. Ongoing studies of epinephrine combined with other agents (eg, hypertonic saline, oral dexamethasone) are needed to confirm their benefit.
Percolation threshold of polymer nanocomposites containing graphite nanoplatelets and carbon nanotubes

An improved analytical model is developed based on an interparticle distance concept, to predict the percolation threshold of conducting polymer composites containing graphite nanoplatelets (GNPs) and carbon nanotubes (CNTs). GNPs are modeled as well-dispersed, disc-shaped cylinders, while CNTs were modeled as either well-dispersed sticks or sphere-shaped CNT agglomerates with a higher CNT concentration than the average CNT content of composites. Two dispersion parameters are introduced in the model to correctly reflect the different dispersion states of CNTs in the matrix. The experimental data collected from literature and previous experiments were compared with the present model, verifying the applicability of the model.
Flow cytometric immunphenotyping of epithelial cancer cells in effusions—Technical considerations and pitfalls

Data regarding the role of flow cytometry (FCM) in the characterization of malignant effusions are limited to date. In the present study, we optimized the conditions for FCM immunphenotyping of effusions using a four‐color analysis and investigated aspects related to the advantages and limitations of this method in this setting.
LARGE OPACITY VARIATIONS IN THE HIGH-REDSHIFT LYα FOREST: THE SIGNATURE OF RELIC TEMPERATURE FLUCTUATIONS FROM PATCHY REIONIZATION

Recent observations of the Lyα forest show large-scale spatial variations in the intergalactic Lyα opacity that grow rapidly with redshift at z > 5 , ? > far in excess of expectations from empirically motivated models. Previous studies have attempted to explain this excess with spatial fluctuations in the ionizing background, but found that this required either extremely rare sources or problematically low values for the mean free path of ionizing photons. Here we report that much—or potentially all—of the observed excess likely arises from residual spatial variations in temperature that are an inevitable byproduct of a patchy and extended reionization process. The amplitude of opacity fluctuations generated in this way depends on the timing and duration of reionization. If the entire excess is due to temperature variations alone, the observed fluctuation amplitude favors a late-ending but extended reionization process that was roughly half complete by z ∼ 9 ? > and that ended at z ∼ 6 . > In this scenario, the highest opacities occur in regions that reionized earliest, since they have had the most time to cool, while the lowest opacities occur in the warmer regions that reionized most recently. This correspondence potentially opens a new observational window into patchy reionization.
Genotype Analysis of Malassezia restricta as the Major Cutaneous Flora in Patients with Atopic Dermatitis and Healthy Subjects

Lipophilic yeasts of the genus Malassezia colonize the skin surface of humans and are an exacerbating factor in atopic dermatitis (AD). Two species, M. restricta and M. globosa are major cutaneous microflora in both AD patients and healthy subjects. We compared the DNA sequences of the intergenic spacer (IGS) region, located between the 26S and 5S rRNA genes of M. restricta colonizing the skin surfaces of 13 AD patients and 12 healthy subjects, and of three CBS stock strains as references. The IGS 1 sequences were divided into two major groups, corresponding to AD patients and healthy subjects. These findings suggest that a specific genotype of M. restricta plays a significant role in AD, although M. restricta commonly colonizes both AD patients and healthy subjects.
Clinical advantages of computer-guided implant placement: a systematic review.

OBJECTIVES To systematically scrutinize the current scientific literature regarding the clinical advantages of computer guidance of implant placement. MATERIALS AND METHODS Four electronic databases were searched using specified indexing terms. The reference lists of publications were also searched manually. For inclusion, publications had to meet pre-established criteria. RESULTS The searches yielded 1028 titles and abstracts. After data extraction and interpretation, 28 publications and 2 systematic reviews remained for inclusion. Fifteen studies were prospective observational and four were retrospective observational. Nine studies included a control group (controlled clinical trials) of which seven were prospective and two retrospective. Only three of the prospective studies were randomized (RCT's). A total of 852 patients were treated with 4032 implants using computer-guided implant surgery. The number of patients included in each study ranged from 6 to 206. The age ranged from 16 to 92 years and the follow-up period varied between 1 and 49 months. CONCLUSIONS The limited scientific evidence available suggests that guided placement has at least as good implant survival as conventional protocols. However, several unexpected procedure-linked adverse events during guided implant placement indicate that the clinical demands on the surgeon were no less than those during conventional placement. A clinical advantage with flapless guided surgery is that the technique is likely to decrease pain and discomfort in the immediate postoperative period.
Interference from Multi-dimensional Objects during Feature and Conjunction Discriminations

Feature discrimination performance within an attended object and interference from irrelevant, multi-dimensional objects (distractors) were examined in a two-choice, response compatibility paradigm. Results showed that the amount of interference by multi-dimensional distractors was dependent on three factors: (1) the discriminability of the incompatible, task-relevant distractor features; (2) the number of incompatible, task-relevant distractor features; and (3) whether the task-relevant, incompatible features matched the task goals. The most interesting finding was that additive priming effects were found for multiple, task-relevant features that matched the task goals, whether these features were present in the attended object or in the ignored object. Models that assume that each task-relevant feature primes its corresponding decision/response asynchronously and that this priming is combined to meet a decision/response criterion (at least when attended) can account for distractor interference during conjunction discriminations. Implications of these findings for feature integration models, template models, and a response selection model are discussed.
Preservation of bowel and urinary continence in the management of locally recurrent rectal cancer

The management of locally recurrent rectal cancer should achieve local tumor control and potentially improving disease‐free and overall survival. Radical pelvic resection has traditionally been associated with permanent fecal and urinary diversion. However, as advanced techniques have evolved to allow restoration of intestinal and urinary continence, we reviewed the use of these techniques in patients with recurrent rectal cancer.
Learning and Transferring Deep ConvNet Representations with Group-Sparse Factorization

Deep convolutional neural networks (Deep ConvNets or CNNs) have exhibited their promise as a universal image representation for recognition. In this work we explore how the transferability of such deep ConvNet representations trained on large-scale annotated object-centric datasets (ImageNet) can be further enhanced for other visual recognition tasks with limited amount of unlabeled training data. We use group-sparse non-negative matrix factorization (GSNMF), a variant of NMF, to identify a rich set of high-level latent variables built from the pre-trained Imagenet deep ConvNets that are informative across scene and fine-grained recognition tasks. The resulting architecture can itself be seen as a feed-forward model that combines deep ConvNets and two-layer structured NMF. We demonstrate state-of-the-art image clustering performance on challenging scene (MIT-67) and fine-grained (Birds-200, Flowers-102) benchmarks. The consistent superior performance of our GSNMF-CNN shows that it is more generic for novel tasks/categories compared to the deep ConvNets activations.
Asymmetric RNA synthesis in vitro: heterologous DNA-enzyme systems; E. coli RNA polymerase.

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Peripapillary Retinal Nerve Fibre Layer Thinning Secondary to Nutritional Folic Acid Deficiency

Abstract Folic acid has a fundamental role in central nervous system (CNS) function at all ages, especially the methionine synthase–mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation. Folic acid and vitamin B12 may have roles in the prevention of disorders of CNS development, mood disorders, and dementias, including Alzheimer disease and vascular dementia in elderly people. The authors examined the peripapillary retinal nerve fibre layer thickness (RNFLT) in patients with nutritional folic acid deficiency using optical coherence tomography (OCT). Patients were divided into two groups according to blood folic acid levels: blood folic acid <7 nmol/L as Group 1 and >7 nmol/L as Group 2. Peripapillary RNFL measurements were performed. There were significant positive correlations between serum folate levels and RNFLT in all quadrants (p < 0.05), except for the temportal quadrant (p = 0.41).
The enzymic conversion of coproporphyrinogen III into protoporphyrin IX

animals moving to high altitudes and thus the stimulation of uroporphyrinogen formation would be small. Nevertheless, it is known that increased haemopoiesis on acclimatization to high altitude is a slow process (cf. Grant & Root, 1952), and small changes in the rate of porphyrin synthesis, maintained for several weeks, could well lead to the observed blood haemoglobin concentrations. Krebs (1959) has pointed out that, though biochemical and hormonal control mechanisms both operate in higher animals, metabolic regulation at the biochemical level assumes great importance in bacteria, which contain no hormones. It is thus conceivable that the regulation by oxygen of haem biosynthesis, described above, may play a part in the changes in haemoprotein concentrations during respiratory adaptation in micro-organisms. Using Aerobacter aerogenes, Moss (1956) has shown that the maximum cell content of cytochrome a2 is obtained when the oxygen concentration in the bacterial culture during growth is 1 ,uM. Above and below this concentration the cytochrome a2 content of the cell falls off in a manner similar to that found for protohaem formation in vitro (Falk et al. 1959).
Reproducibility and validity of a quantitative food-frequency questionnaire among Jamaicans of African origin

Abstract Background: An interviewer-administered quantitative food-frequency questionnaire (FFQ) was developed to determine the energy and nutrient intakes of adult Jamaicans of African origin as part of a study of the epidemiology of diabetes and hypertension. Methods: Reproducibility of the questionnaire was investigated in 123 participants aged 25–74 years. The relative validity of the FFQ was assessed against twelve 24-hour recalls administered over 12 months in 73 of the participants. In addition, energy intakes (EI) were compared with estimated basal metabolic rates (BMR). Results: Reproducibility correlation coefficients (Pearson and intraclass) varied between 0.42 for retinol and 0.71 for carbohydrate, with most values falling between 0.50 and 0.60. When compared with repeated 24-hour recalls, the FFQ estimated slightly higher energy (mean 6%) and macronutrient intakes (mean 2–14%), and was within 5% when expressed as a percentage of energy intake. Micronutrients were higher by 1.19 (calcium) to 1.61 times (vitamin C). Unadjusted correlations between the FFQ and the reference method ranged from 0.20 for beta-carotene to 0.86 for alcohol. Cross-classification of nutrients into quartiles showed that 46–48% of participants in the lowest and highest quartiles were jointly classified by both methods. Misclassifications were low for most nutrients with one or two persons misclassified at the extreme quartiles. EI/BMR ratios suggested light to moderate activity levels appropriate for an urban population in a developing country. Conclusions: The FFQ showed reasonable reproducibility and validity and is suitable for estimating the habitual intakes of energy and macronutrients, but was poor for some micronutrients (retinol and beta-carotene).