Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Effectiveness of Etoricoxib and Diclofenac on Pain and Perioperative Sequelae After Surgical Avulsion of Mandibular Third Molars

Supplemental Digital Content is available in the text. Objective: The objective of this analysis was to compare the efficacy of etoricoxib and diclofenac in the management of perioperative sequelae following impacted mandibular third molar surgery. Materials and Methods: Ninety-seven patients who needed surgical avulsion of an impacted mandibular third molar were chosen for the study. All patients were randomly allocated to receive one of the following treatments, twice a day for 5 days after surgery: placebo (n=33), diclofenac (n=32), or etoricoxib (n=32). The primary outcome evaluated was postoperative pain, recorded by each patient and evaluated using the Visual Analogue Scale score. The secondary outcomes chosen were, compared with preoperative ones, changes in postoperative swelling and maximum mouth opening. Results: Compared with placebo, treatment with etoricoxib and diclofenac demonstrated an enhancement in the primary outcome. Furthermore, when compared with the other groups, patients who had undergone etoricoxib presented a significant median reduction in postoperative pain at 2 hours (P<0.001), 12 hours (P=0.025), and at 48 hours (P=0.018) after surgery. Moreover, the linear regression analysis showed that diclofenac and etoricoxib determined a significant influence on Visual Analogue Scale at 2, 6, 12, 24, 48 hours and at 10 days after surgery. There were no differences in swelling and maximum mouth opening values between groups. Discussion: This study demonstrated that both treatments were effective. However, treatment with etoricoxib showed a greater reduction in the incidence and severity of postoperative pain following third molar surgery compared with diclofenac and placebo.
Trap-Assisted Charge Injection into Large Bandgap Polymer Semiconductors

The trap-assisted charge injection in polyfluorene-poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS) model systems with an Al or Al/LiF cathode is investigated. We find that inserting 1.3 nm LiF increases electron and hole injections simultaneously and the increase of holes is greater than electrons. The evolution of internal interfaces within polymer light-emitting diodes is observed by transmission electron microscopy, which reveals that the introduction of LiF improves the interface stability at both the cathode (cathode/polymer) and the anode (indium tin oxide (ITO)/PEDOT:PSS). Above-mentioned experimental results have been compared to the numerical simulations with a revised Davids model and potential physical mechanisms for the trap-assisted charge injection are discussed.
The effects of lunar cycle on the diurnal variations of short-term maximal performance, mood state, and perceived exertion

ABSTRACT The aim of this study was to explore the effect of the lunar cycle and time of day on short-term maximal performance, wellness and mood state. Twenty healthy active men performed a running anaerobic sprint test (RAST) at four sessions (full moon (FM) and new moon (NM) in the morning and in the evening). Before each testing session, participants completed a rating scale of mood states (POMS) and a psychometric rating scale of perceived wellness (Hooper’s questionnaire). Rating of perceived exertion (RPE) was collected just after the RAST. A higher rating of sleep was observed in FM compared to NM upon the morning and the evening (FM morning vs. NM morning, p < .01; d = 1.38) and (FM evening vs. NM evening, p < .001; d = 2.62). POMS subscales data revealed no significant lunar cycle effect. Peak power (PP), average power (AP) and minimal power (MP) were greater in the evening following NM compared to FM (NM evening vs. FM evening, p< .01, <0.01, <0.05; d = 0.77, = 0.78, = 0.68, respectively). Likewise, RAST performance was greater in the evening compared to the morning for both lunar cycle phases (FM evening vs. FM morning, p< .001, <0.01, <0.01; d = 1.08, = 1, = 0.85) and (NM evening vs. NM morning, p< .001, <0.01, <0.01; d= 1.08, = 1, = 0.85), respectively, for PP, AP, and MP. RPE was higher in the FM evening compared to the NM evening and in the FM morning compared to the NM morning (p < .001, <0.001; d = 1.38, = 2.18, respectively). These results suggest that the lunar cycle and time of day might affect short-term maximal performance with better performance on NM evening associated with a greater perception of sleep quality compared to FM. Abbreviations: AP: Average power; FM: full moon; MP: Minimal power; NM: new moon; RAST: Running anaerobic sprint test; RPE: Rating of perceived exertion; POMS: Rating scale of mood states; PP: Peak power
Pharmacokinetics and Pharmacodynamics of Oral and Intravenous Omadacycline

Abstract Oral and intravenous (IV) omadacycline formulations are approved in the United States for treating acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia in adults. Oral omadacycline bioavailability is 34.5%; similar exposures are obtained following 300 mg oral and 100 mg IV doses. Oral administration should be in a fasted state, with dairy products, antacids, or multivitamins avoided for ≥4 hours after dosing. Low protein binding (21%), large volume of distribution (190 L), low systemic clearance (10 L/hour), and long elimination half-life (16–17 hours) support once-daily dosing. Omadacycline is excreted unchanged in feces (81.1%) and urine (14.4%), with low potential for drug–drug interactions. Dose adjustments are unnecessary for age, sex, and renal or hepatic impairment. Pharmacokinetic–pharmacodynamic studies identify fAUC0–24/MIC ratio as the parameter that correlates with in vivo efficacy. Systemic exposure of omadacycline in epithelial lining fluid is greater than/equal to plasma concentrations in healthy adults.
Gender differences in the use of linguistic features in chat room

Computer Mediated Communication is an electronic way to communicate with other people by utilizing the internet, such as using email, text messaging, and other social networks. Therefore, the chat room that will be analyzed is The Student Room, an online forum where the students across the world can share and discuss their ideas. This study aims to investigate the linguistic feature that is used in chat room. Also, this study reveals on the gender difference in using those linguistic features. To get the answer of the research question, the researcher used the theory formulated by Danet (2001) about linguistic feature in digital writing. In doing this study, the researcher used the descriptive qualitative research to be applied on this study. However, the data were collected by taking nine thread representing nine forums as listed. From these nine threads, the researcher directly coded every word that is included as those linguistic features. Therefore, in answering the second research question, the researcher selected the sample of data by taking 5 representatives of men and women for every thread. The result of this research is there are 8 of 9 linguistic features used in chat room discussion. It comprises multiple punctuation, eccentric spelling, capital letter, description of action, written out laughter, emoticon, abbreviation, and all lower case. There is no asterisk showing to give the stress of a word or a sentence. Further, the second research question provides the result that there are two linguistic features including capital letter, and abbreviations are dominated by men. They used those linguistic features in various form. Therefore, some of linguistic features comprise eccentric spelling, and all lower case are dominated by women. Meanwhile, in the field of multiple punctuation and emoticon, the researcher concludes that between men and women used it equally. Further research is recommended to investigate another area of CMC whether it is spoken or written conversation such as IRC, email, and etc because in this study has proven the linguistic features in chat room in (BBS) and the gender differences in using those linguistic features.
Comparing the Barriers and Facilitators of Heart Failure Management as Perceived by Patients, Caregivers, and Clinical Providers.

BACKGROUND Heart failure (HF) management requires the participation of patients, their significant others, and clinical providers. Each group may face barriers to HF management that may be unique or may overlap. OBJECTIVE The aim of this study was to compare the barriers and facilitators of HF management as perceived by patients, significant others, and clinical providers. METHODS Participants were recruited from a Veterans Health Administration facility. Eligible patients had a diagnosis of HF (ICD9 code 428.XX), 1 or more HF-related visit in the previous year, and a significant other who was their primary caregiver. Significant others were adults with no history of cognitive impairments caring for patients with HF. Providers were eligible if they cared for patients with HF. All participants completed semistructured interviews designed to elicit barriers to managing HF and strategies that they used to overcome these barriers. Interviews were transcribed and analyzed using latent thematic analysis, and recruitment continued until thematic saturation was attained. RESULTS A total of 17 couples and 12 providers were recruited. All 3 groups identified poor communication as a key barrier to HF management, including communication between patients and their significant other, between couples and providers, and providers with each other. Significant others noted that the lack of direct communication with clinical providers hindered their efforts to care for the patient. All 3 groups emphasized the importance of family members in optimizing adherence to HF self-management recommendations. CONCLUSIONS Providers, patients, and significant others all play important and distinct roles in the management of HF. Tools to enhance communication and collaboration for all 3 and supporting the needs of significant others are missing components of current HF care.
Rebuilding core abscisic acid signaling pathways of Arabidopsis in yeast

The phytohormone abscisic acid (ABA) regulates plant responses to abiotic stress, such as drought and high osmotic conditions. The multitude of functionally redundant components involved in ABA signaling poses a major challenge for elucidating individual contributions to the response selectivity and sensitivity of the pathway. Here, we reconstructed single ABA signaling pathways in yeast for combinatorial analysis of ABA receptors and coreceptors, downstream‐acting SnRK2 protein kinases, and transcription factors. The analysis shows that some ABA receptors stimulate the pathway even in the absence of ABA and that SnRK2s are major determinants of ABA responsiveness by differing in the ligand‐dependent control. Five SnRK2s, including SnRK2.4 known to be active under osmotic stress in plants, activated ABA‐responsive transcription factors and were regulated by ABA receptor complexes in yeast. In the plant tissue, SnRK2.4 and ABA receptors competed for coreceptor interaction in an ABA‐dependent manner consistent with a tight integration of SnRK2.4 into the ABA signaling pathway. The study establishes the suitability of the yeast system for the dissection of core signaling cascades and opens up future avenues of research on ligand‐receptor regulation.
Preregistration nursing students’ perceived confidence in learning about patient safety in selected Kenyan universities

Background Improvement of patient safety in Kenya depends on knowledgeable nurses who are equipped with the clinical safety and sociocultural competences of patient safety. Objectives This study assessed the theoretical and practical learning of these competences as perceived by nursing students. Method A cross-sectional descriptive study was conducted on 178 preregistration Bachelor of Nursing students from two Kenyan universities using the Health Professional Education in Patient Safety Survey. This tool assessed the students’ confidence in learning about clinical safety and the sociocultural aspects of patient safety in the classroom and clinical settings. Descriptive statistics summarised the sample and survey responses, while paired t-tests and ANOVA were used to compare responses across learning settings and year of study. Results The students reported higher confidence about learning on the clinical aspects than on the sociocultural issues of patient safety with the lowest mean scores recorded in ‘Understanding human and environmental factors’ and ‘Recognising, responding and disclosing adverse events’. They reported significantly higher confidence scores in the classroom setting than the clinical setting with no significant difference in reported confidence across the years of study. They were less confident in speaking up about patient safety issues in the clinical areas with 52.2% feeling that reporting a patient safety problem will result in negative repercussions. Conclusion Nursing programmes in Kenya need to reinforce the sociocultural aspects of patient safety in the curriculum. The patient safety culture in the clinical placements sites needs to be conducive to enable, and not hinder, the acquisition of these competences.
Microaggressions in Clinical Training and Practice

The term microaggression was coined almost 50 years ago (1970) by Professor Chester Pierce and has re-emerged as a topic of scholarly interest, a contested concept, a social media hashtag, and a polarizing issue in our current political climate. This article is protected by copyright. All rights reserved.
Exploiting the Invariant Structure for Controlling Multiple Muscles in Anthropomorphic Legs: III. Reproducing Hemiparetic Walking from Equilibrium Point– Based Synergies

In the development of a robotic therapy system, tests must be first run to guarantee safety and performance of the system before actual human trials. Lower–limb robotic therapy system has an inherit injury risk and a human–like stunt robot is desirable. This study proposes such an alternative: anthropomorphic legs with a bio–inspired control method affording a human–like test bench for the robotic therapy system. Electromyography (EMG) of a mildly hemiparetic stroke patient was measured during body–weight–supported treadmill walking. The motor strategy of the hemiparetic gait was extracted from the EMG data and applied to the control of the anthropomorphic legs. We employed the concept of equilibrium point (EP) to extract motor synergies and strategy. The EP– based synergies expressed by the composites of muscle mechanical impedance clarified motor strategy including aspects related to the impedance and virtual trajectory. Results show that the EP–based synergies were able to characterize neuromuscular patterns of pathological gait. The anthropomorphic legs were able to reproduce patient’s gait by mimicking the EP–based synergies.
A Case Study on Knowledge Management Implementation in the Banking Sector – Issues and Challenges

Knowledge management has been increasingly seen as one of the most important practices for organisations to improve its efficiency, effectiveness and long-term competitive advantage. This study aims to uncover the issues and challenges faced by banks, in particular, embarking on an enterprise-wide knowledge management implementation. The findings of this case study research is based upon a banking institution (hereafter referred to as XM Bank) rated among the top ten largest banks in Malaysia. The findings, lesson learned and observations were derived after a series of in-depth interviews with key management representatives. The interviews were followed by a survey against a larger population of the bank. The analysis of the findings from the interviews and survey led to an extrapolation of six key lessons learned. The six key lessons learned is a descriptive guideline for knowledge management implementation efforts in the banking sector in particular and organisations in general. Although the study is based on a specific application in one institution (bank), it provides useful insights and awareness of issues and challenges banks, and other institutions might face when implementing knowledge management.
User-driven walking assistance: first experimental results using the MyoSuit*

Wearable robots for the legs have been developed for gait rehabilitation training and as assistive devices. Most devices have been rigid exoskeletons designed to substitute the function of users who are completely paralyzed. While effective for this target group, exoskeletons limit their users’ contributions to movements. Soft wearable robots have been suggested as an alternative that allows, and requires, active contributions from users with residual mobility.In this work, we first tested if the MyoSuit, a lightweight, lower-limb soft wearable robot, affected the walking kinematics of unimpaired users. Secondly, we evaluated the assistance delivered to a patient with a gait impairment.In our first study, 10 unimpaired participants walked on a treadmill at speeds between 0.5 and 1.3 m/s. We found that wearing the MyoSuit in its transparency mode did not affect the participants’ walking kinematics (RMS difference of joint angles < 1.6°). Step length and the ratio of stance-to-stride duration were not affected when wearing the MyoSuit.In our case study with one spinal cord injured participant, the MyoSuit supported the participant to increase his 10 MWT walking speed from 0.36 to 0.52 m/s, a substantial clinically meaningful improvement.Our results show that the MyoSuit allows user-driven, kinematically unaltered walking and provides effective assistance. Systems like the MyoSuit are a promising technology to bridge the gap between rigid exoskeletons and unassisted ambulation.
A Right-Half-Plane Zero-Free Buck-Boost DC-DC Converter with 97.46% High Efficiency and Low Output Voltage Ripple

The right-half-plane (RHP) zero can be eliminated in the proposed buck-boost (BB) converter to achieve fast transients for Internet-of-Thing (IoT) applications. The pseudo-boost mode in the BB converter eliminates one power switch in the current path and ensures that the continuous inductor current is half of the conventional design value to achieve 97.46% peak efficiency. Besides, the output voltage ripple is reduced to 7mV. By inserting an additional phase, a smooth transition between the buck and pseudo-boost modes ensures a voltage drop less than 15mV. The slope-based transient enhancement (SBTE) circuit accelerates transient response in 9 $\mu$S with a load variation of 400 mA.
Identifying the Effects of Assistive and Resistive Guidance on the Gait of Elderly People Using a Smart Walker

Progression of technology has expanded applications of smart walkers in clinical fields. However, it is essential to investigate the effects of different types of gait guidance in order to introduce smart walkers more widely throughout these fields. The purpose of this study was to identify the effects of assistive and resistive guidance on the gait of elderly people using a smart walker. Gait parameters, surface electromyography of lower limb muscles, and trunk acceleration were measured. The assistive guidance force significantly increased gait speed, step length, and cadence while increasing trunk acceleration variability. The same amount of resistive guidance force did not change gait parameters; instead, however, it restrained the speed-dependent increase of trunk acceleration variability in the mediolateral direction. An analysis of muscle activity suggested that the lower limb muscle activity could be increased by varying gait parameters including speed, step length, and cadence.
StretchfMRI: a new technique to quantify the contribution of the reticular formation to long-latency responses via fMRI

Increased reticulospinal (RS) function has been observed to cause both positive and negative outcomes in the recovery of motor function after corticospinal lesions such as stroke. Current knowledge of RF function is limited by the lack of accurate, noninvasive methods for measuring RS function. Recent studies suggest that the RS tract may be involved in processing and generating Long Latency Responses (LLRs). LLRs, elicited by applying precisely controlled perturbations, can act as a reliable stimulus to measure LLR-related brainstem function using fMRI with high signal-to-noise ratio. In this paper, we present StretchfMRI, a new technique that enables simultaneous recording of neural and muscular activity during motor responses conditioned by velocity-controlled robotic perturbations, which allows for direct investigation of the neural correlates of LLRs using fMRI. Via preliminary validation experiments, we demonstrate that our technique can reliably elicit and identify LLRs in two wrist muscles–FCR and ECU. Moreover, via a single-subject pilot experiment, we show that the occurrence of an LLR in a flexor and extensor muscle modulates neural activity in distinct regions of the brainstem. The observed somatotopic organization is in agreement with the double reciprocal model of RS function observed in animal models, in which the right medullary and left pontine reticular formation are responsible for control of the motor activity in flexors and extensors, respectively.
Performance Investigation of Fractional PI Controller in Shunt Active Filter for a Three Phase Four Wire System

Sources of harmonic distortions in the power system are nonlinear loads. Since advancement in properties of semiconductor devices, semiconductor devices are widely used. These devices are showing nonlinear property in the system and causes different power quality problems. Especially in three phase four wire system nonlinear loads or unbalanced load causes flow of zero sequence current through neutral wire. These zero sequence current components are the multiple of third order harmonics. To eliminate these harmonics various technologies has been used including passive filters, zigzag transformers, active filters etc. active filters can be used in different topologies such as series active power filter, shunt active filter etc. In this work shunt active power filter has been used to eliminate the harmonics from the system. For three phase four wire system shunt active power filters compensates not only active and reactive power, but also compensates zero sequence power of the system. The PI controllers are generally used in shunt active filters as control elements. To obtain accurate output result, tuning of PI parameters (proportionality constant Kp, integral constant Ki) are required. While fractional order PI controller are used recently as this type of controller shows better result than conventional PI controller. In fractional PI controller one more constant called as fractional constant λ is also used for tuning.