Miracle-dz/UniFAR-FTUs huggingface dataset:
The Influence of Polysaccharides on the Glass Transition in Frozen Sucrose Solutions and Ice Cream

Abstract The objective of this study was to describe further the mechanism by which polysaccharide stabilizers contribute to stability of frozen dairy desserts. The influence of stabilizers on the thermal properties and viscosity of carbohydrate solutions at subzero temperatures, on the thermal properties of ice cream mix, and on ice crystallization and growth in ice cream were investigated. Polysaccharide stabilizers did not influence the thermal properties of sucrose solutions as measured by differential scanning calorimetry. Stabilizers provided resistance to thermal deformation and increased subzero viscosity above the glass transition temperature but did not influence the experimental glass transition temperature of the solutions or ice cream mix as determined by thermomechanical analysis. The effect of stabilizers on ice crystals in ice cream was demonstrated by low temperature scanning electron microscopy, which showed that the initial ice crystal size and the rate of growth after 24 wk of storage at abusive temperatures were smaller in stabilized ice creams than in unstabilized ice creams. The influence of stabilizers on ice crystal size in ice cream above its glass transition temperature was postulated to be a function of the kinetic properties of the freeze-concentrated, viscoelastic liquid surrounding the ice crystals.
Relative Neuroprotective Effects of Dizocilpine and Isoflurane During Focal Cerebral Ischemia in the Rat

Both dizocilpine (MK-801) and isoflurane antagonize glutamatergic neurotransmission. In this study, we examined the relative neuroprotective effects of these drugs administered in equianesthetic doses before the onset of focal cerebral ischemia. Rats were anesthetized with 1.0%-1.5% isoflurane and surgically prepared for filament occlusion of the middle cerebral artery (MCAO). After preparation, one group (n = 22) remained anesthetized with 0.7% isoflurane. Another group (n = 18) was given dizocilpine (1 mg/kg intraperitoneally), and isoflurane was discontinued. The third group (n = 18) was allowed to awaken immediately after the onset of ischemia. MCAO persisted for 75 min. Epidural temperature was controlled at 37.5[degree sign]C during ischemia and the first 22 h of recovery. A 7-day recovery interval was allowed. Total infarction volumes (mean +/- SD) were less for the dizocilpine group (100 +/- 65 mm3) versus the awake group (182 +/- 36 mm3; P = 0.001). Infarction volumes did not differ significantly between the isoflurane group (142 +/- 81 mm3) and either the dizocilpine (P = 0.11) or the awake group (P = 0.15). Isoflurane was examined at doses used clinically but smaller than those found to reduce N-methyl-D-aspartate (NMDA)-mediated injury in vitro. This study supports the hypothesis that NMDA receptor activation is injurious during focal ischemia and that amelioration of focal ischemic brain damage by NMDA receptor antagonists persists under normothermic conditions. Implications: Rats underwent focal cerebral ischemia with rigid maintenance of brain normothermia. The glutamate receptor antagonist dizocilpine was effective in reducing cerebral infarction size during persistent conditions of brain normothermia. In contrast, isoflurane administered at equianesthetic doses did not reduce infarction size. This study supports the hypothesis that N-methyl-D-aspartate receptor activation is injurious during focal ischemia and that amelioration of focal ischemic brain damage by N-methyl-D-aspartate receptor antagonists persists under normothermic conditions. (Anesth Analg 1998;87:72-8)
Vasoconstrictor fibre discharge to skeletal muscle, kidney, intestine and skin at varying levels of arterial baroreceptor activity in the cat.

Estimations of the average discharge rates in vasoconstrictor fibres to skeletal muscle, kidney, intestine and skin at varying levels of arterial baroreceptor activity were made by comparing quantitatively the reflexly induced vascular responses with those obtained with stimulations of the regional vasoconstrictor fibres at known frequencies. The results indicate that withdrawal of baroreceptor restraint was normally followed by a considerably lower firing rate in renal vasoconstrictor fibres than in e.g. skeletal muscle vasoconstrictor fibres. A complete elimination of the inhibitory influence induced vasoconstrictor fibre discharge rates up to 8 imp/s in skeletal muscle but only at most 4 imp/s in the kidney. Intestinal vasomotor fibres were found to be activated to approximately the same extent as those to skeletal muscle. The vasomotor fibres to the cutaneous arterio-venous anastomoses were evidently not activated when the baroreceptors were unloaded. The reason for this non-uniform activation of the different sets of vasoconstrictor fibres seems to be different levels of spontaneous activity in the respective “neuron pools” in the bulbar vasomotor centre. The renal vascular responses to baroreceptor unloading became augmented when the excitatory level in the vasomotor centre was enhanced, as e.g. when the animal became acidotic.
Author's reply to Coggon commentary on epidemiological investigation of prognosis.

Print ISSN: 0355-3140 Electronic ISSN: 1795-990X Copyright (c) Scandinavian Journal of Work, Environment & Health Letter to the Editor Scand J Work Environ Health 2009;35(6):479 doi:10.5271/sjweh.1351 Author’s reply to Coggon commentary on epidemiological investigation of prognosis by Detaille SI, Heerkens YF, Engels JA, van der Gulden JWJ, van Dijk FJH Affiliation: HAN University of Applied Sciences, Verlengde Groenestraat 75, PO Box 6960 GL Nijmegen, the Netherlands. sarah.detaille@han.nl Refers to the following texts of the Journal: 2009;35(4):241-319 2009;35(4):241-319 The following article refers to this text: 2013;39(1):1-120 Key terms: author’s reply; commentary; epidemiological investigation; letter to the editor; prognosis
Origins and Evolution of the Etruscans’ mtDNA

The Etruscan culture is documented in Etruria, Central Italy, from the 8th to the 1st century BC. For more than 2,000 years there has been disagreement on the Etruscans’ biological origins, whether local or in Anatolia. Genetic affinities with both Tuscan and Anatolian populations have been reported, but so far all attempts have failed to fit the Etruscans’ and modern populations in the same genealogy. We extracted and typed the hypervariable region of mitochondrial DNA of 14 individuals buried in two Etruscan necropoleis, analyzing them along with other Etruscan and Medieval samples, and 4,910 contemporary individuals from the Mediterranean basin. Comparing ancient (30 Etruscans, 27 Medieval individuals) and modern DNA sequences (370 Tuscans), with the results of millions of computer simulations, we show that the Etruscans can be considered ancestral, with a high degree of confidence, to the current inhabitants of Casentino and Volterra, but not to the general contemporary population of the former Etruscan homeland. By further considering two Anatolian samples (35 and 123 individuals) we could estimate that the genetic links between Tuscany and Anatolia date back to at least 5,000 years ago, strongly suggesting that the Etruscan culture developed locally, and not as an immediate consequence of immigration from the Eastern Mediterranean shores.
The application kernel approach—a novel approach for adding SMP support to uniprocessor operating systems

The current trend of using multiprocessor computers for server applications requires operating system adaptations to take advantage of more powerful hardware. However, modifying large bodies of software is very costly and time consuming, and the cost of porting an operating system to a multiprocessor might not be motivated by the potential performance benefits. In this paper we present a novel method, the application kernel approach, for adaption of an existing uniprocessor kernel to multiprocessor hardware. Our approach considers the existing uniprocessor kernel as a ‘black box’, to which no or very small changes are made. Instead, the original kernel runs operating system services unmodified on one processor whereas the other processors execute applications on top of a small custom kernel. We have implemented the application kernel for the Linux operating system, which illustrates that the approach can be realized with fairly small resources. We also present an evaluation of the performance and complexity of our approach, where we show that it is possible to achieve good performance while at the same time keeping the implementation complexity low. Copyright © 2006 John Wiley & Sons, Ltd.
Horizontal and vertical movements as predictors of foraging success in a marine predator

With technical advances in wildlife telemetry, the study of cryptic predators' responses to prey distribution has been revolutionised. In the case of marine predators, high resolution tagging devices have been developed recently to collect precise diving datasets covering extended periods of time. In this study, we investigated changes in the horizontal movements and diving patterns of a marine predator, the southern elephant seal, at fine temporal and spatial scales. Satellite tracking data collected for 9 seals were processed with switching state-space models. Seal body condition, as a proxy for foraging success, was estimated through changes in drift rate from Time Depth Recorder (TDR) data. We identified (1) statistically distinct behavioural modes from the tracking data (intensive vs. extensive foraging modes) and (2) distinct dive classes from the TDR diving data (drift, exploratory, shallow active and deep active dives). Active dives, associated with vertical foraging and chasing, were more numerous when the seals were in intensive foraging mode. Improved body condition and mass gain of seals were also associated with the intensive foraging mode and, within the vertical dimension, with sets of highly active dives. In conclusion, proportions of dive classes varied according to seals' horizontal behaviour. Intensive foraging detected from surface tracking data is a good predictor of diving activity and foraging success occurring in the vertical dimension.
Presence of Coxiella burnetii DNA in the Environment of the United States, 2006 to 2008

ABSTRACT Coxiella burnetii is an obligate intracellular bacterium that causes the zoonotic disease Q fever. Because C. burnetii is highly infectious, can survive under a variety of environmental conditions, and has been weaponized in the past, it is classified as a select agent and is considered a potential bioweapon. The agent is known to be present in domestic livestock and in wild animal populations, but the background levels of C. burnetii in the environment have not been reported. To better understand the amount of C. burnetii present in the environment of the United States, more than 1,600 environmental samples were collected from six geographically diverse parts of the United States in the years 2006 to 2008. DNA was purified from these samples, and the presence of C. burnetii DNA was evaluated by quantitative PCR of the IS1111 repetitive element. Overall, 23.8% of the samples were positive for C. burnetii DNA. The prevalence in the different states ranged from 6 to 44%. C. burnetii DNA was detected in locations with livestock and also in locations with primarily human activity (post offices, stores, schools, etc.). This study demonstrates that C. burnetii is fairly common in the environment in the United States, and any analysis of C. burnetii after a suspected intentional release should be interpreted in light of these background levels. It also suggests that human exposure to C. burnetii may be more common than what is suggested by the number of reported cases of Q fever.
Distributed modeling of human influenza a virus–host cell interactions during vaccine production

This contribution is concerned with population balance modeling of virus–host cell interactions during vaccine production. Replication of human influenza A virus in cultures of adherent Madin–Darby canine kidney (MDCK) cells is considered as a model system. The progress of infection can be characterized by the intracellular amount of viral nucleoprotein (NP) which is measured via flow cytometry. This allows the differentiation of the host cell population and gives rise to a distributed modeling approach. For this purpose a degree of fluorescence is introduced as an internal coordinate which is linearly linked to the intracellular amount of NP. Experimental results for different human influenza A subtypes reveal characteristic dynamic phenomena of the cell distribution like transient multimodality and reversal of propagation direction. The presented population balance model provides a reasonable explanation for these dynamic phenomena by the explicit consideration of different states of infection of individual cells. Kinetic parameters are determined from experimental data. To translate the emerging infinite dimensional parameter estimation problem to a finite dimension the parameters are assumed to depend linearly on the internal coordinate. As a result, the model is able to reproduce all characteristic dynamic phenomena of the considered process for the two examined virus strains and allows deeper insight into the underlying kinetic processes. Thus, the model is an important contribution to the understanding of the intracellular virus replication and virus spreading in cell cultures and can serve as a stepping stone for optimization in vaccine production. Biotechnol. Bioeng. 2013; 110: 2252–2266. © 2013 Wiley Periodicals, Inc.
Animal Bites to the Head and Neck

There is controversy regarding the timing of repair and the use of prophylactic antibiotics in patients with animal bites to the head and neck. In this paper we review our experience with such wounds, and address surgical management and the use of prophylactic antibiotic therapy. A retrospective review of the medical records of 29 patients with animal bites to the head and neck was conducted. All patients were seen and treated at a large teaching hospital in Houston, Texas over an 18-month period. Seventy-six percent of our patients were 12 years old or younger. Most came to the emergency room soon after sustaining their injuries, and their wounds were repaired primarily with favorable results. There were no cases of wound infection. Ninety percent were treated with prophylactic antibiotics. The wounds of the 10% of patients who did receive antibiotics were similar to those of the other patients and healed well without infection. Wounds resulting from animal bites to the head and neck can be repaired primarily when treated shortly after injury. Further prospective, randomized studies are recommended to evaluate the effectiveness and necessity of prophylactic antibiotic therapy in this patient population.
How many people return to work after acquired brain injury?: A systematic review

Primary objective: To investigate how many people return to work (RTW) after acquiring brain injury (ABI) due to traumatic or non-traumatic causes. Secondary objectives were to investigate the differences in outcome between traumatic and non-traumatic causes, the development of RTW over time and whether or not people return to their former job. Methods: A systematic literature search (1992–2008) was performed using terms of ABI and RTW. The methodological quality of the studies was determined. An overall estimation of percentage RTW 1 and 2 years post-injury was calculated by data pooling. Main outcomes and results: Finally, 49 studies were included. Within 2 years post-injury, 39.3% of the subjects with non-traumatic ABI returned to work. Among people with traumatic ABI, 40.7% returned to work after 1 year and 40.8% after 2 years. No effect of cause or time since injury was found. Some people with traumatic ABI who returned to work were not able to sustain their job over time. Changes of occupation and job demands are common among people with ABI. Conclusions: About 40% of the people with traumatic or non-traumatic ABI are able to return to work after 1 or 2 years. Among those with acquired traumatic brain injury a substantial proportion of the subjects were either not able to return to their former work or unable to return permanently.
Using GIFT to Support an Empirical Study on the Impact of the Self-Reference Effect on Learning

A study is reported in which participants gained experience with deductive reasoning and learned how to complete logic grid puzzles through a computerized tutorial. The names included in the clues and content of the puzzle varied by condition. The names present throughout the learning experience were either the participant’s own name, and the names of two friends; the names of characters from a popular movie/book series (Harry Potter); or names that were expected to have no relationship to the individual participant (which served as a baseline). The experiment was administered using the Generalized Intelligent Framework for Tutoring (GIFT). GIFT was used to provide surveys, open the experimental programs in PowerPoint, open external web-sites, synchronize a Q-sensor, and extract experimental data. The current paper details the study that was conducted, discusses the benefits of using GIFT, and offers recommendations for future improvements to GIFT.
Localization of indoor robot based on particle filter with EKF proposal distribution

The indoor localization of the mobile robot is an important problem. The laser sensor is commonly used in the localization of robot. However, a low-cost LIDAR usually leads to a poor localization result because of the sparse scan points. In face of this problem, map based particle filter localization in indoor environment is realized for the robot equipped with 2D LIDAR. The proposal distribution is obtained from fusing the motion model prior and the most recent measurement by Extended Kalman Filter (EKF). We analyzed the prior distribution and the EKF distribution and realized the particle filter localization on the robot. Experiments show this method is effective.
The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice

In Escherichia coli, the SoxRS regulon is required for resistance to redox-cycling agents which elevate cytosolic superoxide levels, as well as for resistance to nitric oxide-dependent macrophage killing. In Salmonella typhimurium, SoxS is also required for enhanced expression of Mn-superoxide dismutase and resistance to paraquat, but not for resistance to nitric oxide donor compounds in vitro, resistance to macrophage killing, or virulence in mice. Differences in other antioxidant defense systems or compensation by homologous regulons may account for species-specific differences in the role of SoxS.
Modeling Strategic Electricity Storage: The Case of Pumped Hydro Storage in Germany

We study the strategic utilization of storage in imperfect electricity markets. We apply a game-theoretic Cournot model to the German power market and analyze different counterfactual and realistic cases of pumped hydro storage. Our main finding is that both storage utilization and storage-related welfare effects depend on storage ownership and the operator's involvement in conventional generation. Strategic operators generally under-utilize owned storage capacity. Strategic storage operation may also lead to welfare losses, in particular if the total storage capacity is controlled by an oligopolistic generator that also owns conventional generation capacity. Yet in the current German situation, pumped hydro storage is not a relevant source of market power.
Killing of Blood-Stage Murine Malaria Parasites by Hydrogen Peroxide

Both nonlethal Plasmodium yoelii and lethal Plasmodium berghei were killed in vitro by hydrogen peroxide at concentrations as low as 10−5 M. Higher concentrations were required in the presence of added normal erythrocytes. Injection of hydrogen peroxide in vivo significantly reduced P. yoelii parasitemia but had less effect on P. berghei.
Tumour budding in colorectal carcinoma

The term tumour budding denotes that at the invasion front of colorectal adenocarcinomas tumour cells, singly or in small aggregates, become detached from the neoplastic glands. This morphological feature is increasingly being recognized as a strong and robust adverse prognostic factor. Biologically, tumour budding is closely related to the epithelial–mesenchymal transition. In this review the morphological features of tumour budding are discussed, as observed by the surgical pathologist reporting colorectal carcinoma resection specimens. The morphological features are put into context with the rapidly expanding knowledge of the epithelial–mesenchymal transition in general, and the molecular pathology of colorectal carcinoma in particular. Finally, a systematic analysis of the relevant published clinicopathological studies emphasizes the potential of tumour budding as a prognostic factor for routine surgical pathology.
Difference in T helper responses during hepatitis flares in hepatitis B e antigen (HBeAg)‐positive patients with genotypes B and C: implication for early HBeAg seroconversion

Summary. The underlying mechanisms for earlier hepatitis B e antigen (HBeAg) seroconversion in patients with chronic hepatitis B virus (HBV) genotype B when compared with genotype C are unknown. We aimed to determine whether there were any differences in the T helper (Th) responses during hepatitis flares in HBeAg‐positive patients with genotypes B and C. Proliferative response measured by 3H‐thymidine uptake and Th responses measured by Enzyme‐Linked Immunosorbent Spot assays for interleukin (IL)‐2, interferon‐gamma (IFN‐γ), IL‐4, IL‐5 and IL‐10 were performed in 10 patients with genotype B and 10 with genotype C with hepatitis flares. HBV genotypes, core promoter, precore mutations, sequence of HBV core region and HBV DNA levels were determined. There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN‐γ producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL‐10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively). There was a trend (P = 0.058) that patients with genotype B had a higher cumulative rate of HBeAg seroconversion. Patients with precore mutants also had a significantly higher number of IFN‐γ producing cells (with HBcAg stimulation) and lower number of IL‐10 producing cells (with HBeAg stimulation) compared to patients without precore mutant (P = 0.038, =0.016 respectively). HBV genotype B induces a greater Th1 and lesser Th2 response than genotype C. This provides immunologic evidence for the higher chance of HBeAg seroconversion in patients with genotype B.
A psychophysiological study of the use of partial information in stimulus-response translation.

Ss performed a hybrid go/no-go reaction task in which colored letters were assigned in various ways to 4 finger responses, 2 on each hand. In addition to reaction time, psychophysiological measures were used to assess the duration of stimulus identification and the onset of central and peripheral motor activity. The results suggest that response selection can begin on the basis of 1 stimulus dimension (e.g., color), while the other dimension (e.g., letter form) has not yet been identified. Other results are discussed with regard to "selection for action" (Allport, 1987) and the importance of stimulus-response translation strategies in the use of partial information.