Miracle-dz/UniFAR-FTUs huggingface dataset:
The state of sustainability reporting assurance in the United Kingdom: perspectives of assurance providers and stakeholders

Sustainability reporting assurance is considered as a practice that enhances the credibility and quality of reported information (Dando and Swift, 2003; ACCA, 2004). However, studies have found significant variances and inconsistencies that exist across assurance statements but little attention has been paid to understanding more about the nature of the variances beyond the examination of assurance statements. The apparent variances affect the ability of sustainability assurance to deliver robust levels of stakeholder accountability; as such a detailed exploration behind the dynamics of stakeholder consideration in the practice is required. Hence, this study presents an updated and expanded assessment of sustainability reporting assurance practices by adopting a three-stage mixed methods investigative approach. The first stage is a content analysis of assurance statements published by FTSE350 companies using a specifically developed evaluation template. Core elements such as scope of assurance, level of assurance, addresses, guidelines used, independence of assurance providers, assurance work undertaken, stakeholder consideration and conclusions were of particular focus. Data obtained on these elements were explored further in the subsequent stages of the study. The second stage involved semi-structured interviews with 13 assurance providers focusing on their roles in the process and the apparent variances that appear in assurance statements. The third stage is comprised of further semi-structured interviews with representatives of 11 different stakeholders. All data generated were analysed and interpreted through the audit theoretical conception by Power (1991, 1994, 1999) as well as the legitimacy, institutional and stakeholder theories. Sustainability reporting assurance remains largely a valuable practice but there is a fundamental absence of consistent and comprehensive shared meaning and approach on the practice. This has manifested in the different application of sustainability assurance processes thus making it challenging for a single approach to be generally accepted. Also, considerable evidence of managerial capture was observed as assurance providers confirmed the vast degree of influence exerted by reporting companies in assurance processes, an issue that no direct solution or effort was acknowledged to assist in alleviating. The presence of a sustainability assurance expectations gap serves as a key factor that drives the severe caution expressed by stakeholders about the practice. The lack of stakeholder influence was apparent, thus limiting their ability to put companies and assurance providers under pressure towards a more stakeholder oriented provision of sustainability assurance. In general, the findings of this study call into question the ability of the current state of sustainability reporting assurance to enhance transparency and hence discharge effective corporate accountability to stakeholders.
Transposed Brachiobasilic Fistula or PTFE Arm Graft - Alternative or Complementary?

Purpose Our primary aims were (1) to examine the patency of transposed brachiobasilic (TBB) fistulae compared to arm arteriovenous graft (AVG) without prior transposition, and (2) to examine the patency of AVG with and without prior transposition. Methods Single institution; analysis of prospectively collected data between January 2001 and January 2007. Dedicated database and medical records were reviewed and results analyzed with SPSS. Results Ninety-one patients underwent 111 procedures (52 TBB: 39 AVG as index); 28 TBB failed with 17 (60%) being replaced with an ipsilateral AVG. TBB compared to AVG (without prior TBB) had significantly (log rank <0.05) better primary, primary assisted and secondary patency. Secondary patency at 2 yrs was 47% to 33%, respectively. Ipsilateral AVG after TBB to primary AVG had superior patency rates (secondary patency at 2 yrs 52 vs. 33%) but did not reach significance (log rank =0.073). Combined secondary patency of TBB and AVG after TBB was 81% at 2 yrs. Conclusions The TBB offers an autogenous fistula in the upper arm which has superior patency rates to an arm AVG. Once a TBB has failed an ipsilateral AVG is technically feasible and may offer better patency than a primary AVG.
Functional and morphological features of isolated hepatocytes preserved in university of wisconsin solution

Although several studies suggest that hepatic graft failure after cold ischemia results from nonparenchymal cell damage, other data indicate that hepatocellular ATP content is significantly correlated with the transplantation success rate. In this study, we have conducted a systematic investigation of various aspects of cell viability and function of isolated hepatocytes stored at 4°C for 24 and 48 hr in either University of Wisconsin solution or Hanks' HEPES buffer, a control solution clinically unsuitable for organ preservation. After 24 hr, hepatocytes stored in Hanks' HEPES buffer had viability (measured by trypan blue exclusion and ALT and lactic dehydrogenase leakage), transport function (measured by 22Na+ and [3H]taurocholate uptake) and cell size similar or only slightly altered when compared with freshly isolated and University of Wisconsin solution‐stored hepatocytes. ATP content was decreased in both groups; however, the reduction was much greater in Hanks' HEPES buffer‐stored cells. Furthermore, ATP regenerating capacity was greatly reduced in Hanks' HEPES buffer‐stored but not in University of Wisconsin solution‐stored hepatocytes. By 48 hr viability and function of Hanks' HEPES buffer‐stored hepatocytes were decreased; University of Wisconsin solution afforded partial protection. When examined by light and electron microscopy, cells stored in both University of Wisconsin solution and Hanks' HEPES buffer for 24 hr appeared essentially normal except for the presence of numerous membrane blebs in the Hanks' HEPES buffer group. Tissue sections of livers preserved in Hanks' HEPES buffer but not in University of Wisconsin solution revealed the presence of extensive amounts of blebs in the sinusoidal lumen and loss of endothelial elements. This study indicates that isolated hepatocytes are remarkably resistant to 24‐hr cold ischemia. However, the resulting low ATP levels may be responsible for formation of membrane blebs, the shedding of which, in vivo, may lead or contribute to microcirculatory disturbances. These findings may potentially explain the relationship between hepatocellular ATP content and regenerating capacity and the clinical outcome of liver transplantation. (HEPATOLOGY 1991;14:331–339.)
New Zealand’s Primary Health Care Strategy: early effects of the new financing and payment system for general practice and future challenges

Abstract Since 2001, implementation of a New Zealand’s Primary Health Care Strategy (the Strategy) has led to an increase in the proportion of primary health care services which are publicly funded, the development of 82 primary health organisations (PHOs) to oversee primary health care services and universal public capitation funding of PHOs. This approach has replaced the previous system of fee-for service targeted public subsidies paid to individual general practitioners (GPs). Patient copayments, although at a reduced level but still set by individual practitioners, have remained a core feature of the system. This paper focuses on the implementation and impact of key policy changes over the first five years of the Strategy. Although patient copayments have fallen and consultation rates have increased, the new funding and payment system has raised a number of unresolved issues – whether to retain the new universal funding system or revert to the former targeted approach; how to achieve the potential gains from capitation when GPs continue to receive their income from a variety of sources and in a variety of different ways; and how to manage the potential for ‘cream skimming’. Recent improvements in access may, in time, improve health status and reduce inequalities in health, but there is no guarantee that a universal system will necessarily improve average health or reduce inequalities. Much depends on the services being delivered and the populations that are benefiting most – something New Zealand needs better evidence on before determining future policy directions in primary health care.
Increasing incidence of multiple sclerosis among women in Lorraine, Eastern France

This study aims to describe the prevalence and incidence rates of multiple sclerosis (MS) in Lorraine, France, and its secular trend from 1990 to 2002. Cases were sourced from the regional network of MS healthcare workers in the Lorraine region and include all cases with definite or probable MS according to Poser's criteria. We identified 2718 patients with MS on 31 December 2004. The prevalence rate was 120/100 000 (95% confidence interval [CI]: 119—121). Between 1990 and 2002, the average age- and sex-adjusted annual incidence rate was 5.5/100 000 (95% CI: 4.4—6.6). During this same period, there was a significant increase in overall incidence in women but not in men. The mean age at MS onset, disability score five years after onset, number of relapses during the first five years, and proportion of first attack with sequelae or polysymptomatic symptoms were not significantly different between each annual cohort during the study period. The prevalence and incidence rates of MS we found in our study were higher than in previous studies in France. The increase in incidence of MS between 1990 and 2002, mostly in women, was not related to better ascertainment of patients with mild disability. Multiple Sclerosis 2007; 13: 962—967. http://msj.sagepub. com
Exploring the prevalence of and factors associated with advice on prescription medicines: A survey of community pharmacies in an English city

Service users rely upon pharmacy staff to provide advice on prescription medicines. The purpose of this study was to compare the prevalence of advice-giving in pharmacies located across different areas within an inner-city population. A questionnaire was administered with service users outside 29 community pharmacies in an English Midlands city between February and July 2014. The primary outcome measure was the percentage who had received information or advice when collecting a prescription medicine. A total of 1206 service users took part, of whom 49.1% were female and 50.9% were of minority ethnicity (48.8% white British). The age ranges were: 17-30 years (21.0%), 31-60 years (55.0%) and 61-80+ years (24.1%). Sixty-nine per cent of participants had collected a prescription for themselves, and the proportions of new and repeat prescriptions were 22.1% and 77.6% respectively. A subset of 141 participants had requested advice, of whom 94% confirmed that they had received it. Overall, 28.6% of 1065 participants received unsolicited information or advice. The overall prevalence of unsolicited advice-giving varied per pharmacy from 14% to 63% and for new and repeat prescriptions was 41.9% and 25.5% respectively (p < .001, new vs repeat). In areas of greater deprivation, a higher proportion of service users of minority ethnicity received unsolicited repeat prescription advice, compared to that of white British (33.0% vs 17.3% respectively; p < .001). Thus, the low incidence and contrasting patterns of prescription advice-giving suggests that the training and expertise of pharmacy staff may not always be used effectively within the UK NHS. Therefore, the current challenge is how community pharmacies can work in partnership with colleagues across the wider healthcare system when optimising the use of medicines and reducing health inequalities. The research performed here provides new insights reflecting the low prevalence of advice-giving and potential inequity associated with delivery of this pharmacy service.
Disease Progression Increases the Risk of Skeletal-Related Events in Patients With Bone Metastases From Castration-Resistant Prostate Cancer, Lung Cancer, or Other Solid Tumors

ABSTRACT Baseline and disease progression characteristics may predict the risk of skeletal-related events (SREs) in patients with bone metastases from various solid tumors. Exploratory analysis of phase III trials compared zoledronic acid with placebo in patients with bone metastases from castration-resistant prostate cancer (N = 643) and lung cancer or other solid tumors (N = 773), adjusted for baseline and time-dependent disease parameters. In all models, more than three bone lesions at baseline correlated with the increased SRE risk. Bone and overall disease progression correlated with increased SRE risk. Overall, cancer progression correlated with increased SRE risks and zoledronic acid was associated with reduced SRE risks versus placebo.
Zero-shot Learning via Shared-Reconstruction-Graph Pursuit

Zero-shot learning (ZSL) aims to recognize objects from novel unseen classes without any training data. Recently, structure-transfer based methods are proposed to implement ZSL by transferring structural knowledge from the semantic embedding space to image feature space to classify testing images. However, we observe that such a knowledge transfer framework may suffer from the problem of the geometric inconsistency between the data in the training and testing spaces. We call this problem as the space shift problem. In this paper, we propose a novel graph based method to alleviate this space shift problem. Specifically, a Shared Reconstruction Graph (SRG) is pursued to capture the common structure of data in the two spaces. With the learned SRG, each unseen class prototype (cluster center) in the image feature space can be synthesized by the linear combination of other class prototypes, so that testing instances can be classified based on the distance to these synthesized prototypes. The SRG bridges the image feature space and semantic embedding space. By applying spectral clustering on the learned SRG, many meaningful clusters can be discovered, which interprets ZSL performance on the datasets. Our method can be easily extended to the generalized zero-shot learning setting. Experiments on three popular datasets show that our method outperforms other methods on all datasets. Even with a small number of training samples, our method can achieve the state-of-the-art performance.
3D finite element modeling and analysis of dynamic force in bone drilling for orthopedic surgery

Three‐dimensional finite element modeling and analysis are made to simulate the dynamic process of bone drilling during the orthopedic surgery. This study is proposed to evaluate the performance of various surgical tools and the possible pre‐operative biohazard. In the simulation, the strain–stress curve of the bone is divided into linear elastic region and nonlinear plastic region according to the strain range. Rigid‐plasticity and elasto‐plasticity are used as bone material. The performances of twist drill bit and hollow drill bit are evaluated. The results of finite element analysis give different patterns of stress distribution on the two types of bone models and drill bits. The FE simulations show dynamic drilling process that the drill bit penetrates through the bone model. In vitro drilling experiment on porcine femur is conducted to measure the drilling force for the validation of the FEM. Copyright © 2014 John Wiley & Sons, Ltd.
Mind the Gap: Towards Determining Which Collocations to Teach

Collocations form part of formulaic language use that is considered by many scholars as central to communication (Henriksen 2013; Wray 2002). Today, most scholars agree that teaching collocations to second and/or foreign language users (henceforth “L2 students”) is a must. This study offers a reflection on the directions L2 researchers and teachers may explore, and that could contribute to modelling the teaching of collocations or at least spark the debate on this issue. The fundamental point raised here is the extent to which pedagogy may be informed by knowing the most common lexical collocations (combinations of content words) and using frequency of collocates as a key factor in selecting which collocations to bring to learners’ attention. The results from this study indicate that out of the eight different lexical collocations, adjective+noun and verb+noun collocations are the most common, and should therefore be introduced first. Furthermore, most collocates (“co-occurring words” in Sinclair’s (1991) terms) come from the 1,000 and 2,000 most frequent words. Therefore, this study suggests that the same way that “[u]sing the computational approach as a starting point makes it possible to distinguish between collocations of varying frequency of use” (Henriksen 2013: 32), frequency may be used to select the target words and their collocates once collocations have been identified. This could potentially contribute to addressing the issue of selection criteria of which collocations to teach.
Density and proximity of fast food restaurants and body mass index among African Americans.

OBJECTIVES The purpose of this study was to address current gaps in the literature by examining the associations of fast food restaurant (FFR) density around the home and FFR proximity to the home, respectively, with body mass index (BMI) among a large sample of African American adults from Houston, Texas. METHODS We used generalized linear models with generalized estimating equations to examine associations of FFR density at 0.5-, 1-, 2-, and 5-mile road network buffers around the home with BMI and associations of the closest FFR to the home with BMI. All models were adjusted for a range of individual-level covariates and neighborhood socioeconomic status. We additionally investigated the moderating effects of household income on these relations. Data were collected from December 2008 to July 2009. RESULTS FFR density was not associated with BMI in the main analyses. However, FFR density at 0.5, 1, and 2 miles was positively associated with BMI among participants with lower incomes (P ≤ .025). Closer FFR proximity was associated with higher BMI among all participants (P < .001), with stronger associations emerging among those of lower income (P < .013) relative to higher income (P < .014). CONCLUSIONS Additional research with more diverse African American samples is needed, but results supported the potential for the fast food environment to affect BMI among African Americans, particularly among those of lower economic means.
Pesticide use in Vietnamese vegetable production: a 10-year study

Vietnam has had varying success over the past decade with its pesticides policy. Some of the most toxic pesticides have been banned from the market. But while many countries have successfully decreased agricultural pesticide use per hectare, this has not (yet) happened in Vietnam. Due to insufficient pesticide management capacity of the Vietnamese government, pesticide types and quantities registered and distributed on the market have substantially increased in Vietnam over the last 10 years. A 10-year monitoring programme at farm level showed that pesticide use follows the increasing pesticide availability on the market, and many toxic and illegal pesticides are still being used. In an agricultural country dominated by millions of small-scale farmers and with limited state capacity for control at farm level, reduction of the use of the most toxic pesticides can best be achieved by more effective pesticide market control through stricter and more effective state regulations and implementation, aimed at eliminating illegal, low quality and counterfeit pesticides from the market. But even then, better state and private extension services, and greater state capacity for control and enforcement remain essential in enabling farmers to make better decisions about pesticide use.
EXISTENCE OF A SPERMATOGONIAL CHALONE IN THE RAT TESTIS

Adult rats with normal or X‐irradiated testes were used in an experiment to test the possible existence of a chalone in the testis. On the 11th day following irradiation, i.e. as the type A spermatogonia proliferated actively to restore the partially destroyed spermatogonial population, the animals with irradiated testes were subdivided into three groups. Rats of the first group were injected intraperitoneally with a saline extract of normal adult rat testes. Animals of the second group were injected with an equal amount of physiological saline while the rats of the third group received equivalent injections of a saline liver extract. Two additional groups of rats with non‐irradiated testes, injected with the testicular extract or saline solution, served as controls. Following the last injection all animals were injected with 3H‐thymidine and sacrificed. From each animal one testis was used to determine the specific radioactivity of its DNA, the other testis was processed for radioautography. The testicular extract produced a significant decrease in uptake of radioactivity by the irradiated testes. There was no difference in the radioactivity uptake by the testes of non‐irradiated rats. Correspondingly the labeling index of type A spermatogonia was significantly lower in animals of the first group than in the other two groups of animals with irradiated testes. However, there was no difference in the labeling indices of Intermediate and type B spermatogonia or of preleptotene spermatocytes in the animals receiving the extracts or the saline solution. In animals with non‐irradiated testes there was no difference in the labeling indices of type A or other types of spermatogonia or of spermatocytes. These data were taken to indicate that a saline extract of normal adult testes contains a substance that can inhibit specifically the proliferation of type A spermatogonia during the repair phase of the spermatogonial population following irradiation. This substance was tentatively considered as a spermatogonial chalone.
Differential c‐myc expression profiles in normal human bronchial epithelial cells following treatment with benzo[a]pyrene, benzo[a]pyrene‐4,5 epoxide, and benzo[a]pyrene‐7,8‐9,10 diol epoxide

Bronchial epithelial cells are often exposed to airborne mutagens that have the potential to induce genetic changes involved in the development of lung cancer. Although lung tumors often display alterations in the expression of oncogenes and/or tumor suppressor genes, the role of specific chemicals and/or metabolites in causing these alterations is not well defined. The polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P), a by‐product of combustion, is a prevalent airborne environmental mutagen and a constituent of cigarette smoke. The primary objective of this study was to compare the effect of B[a]P and two of its reactive metabolites, benzo[a]pyrene diol epoxide (BPDE or bay region epoxide) and benzo[a]pyrene‐4,5‐dihydroepoxide (BPE or K‐region epoxide), on expression of the proto‐oncogene c‐myc in normal human bronchial epithelial (NHBE) cells using a quantitative reverse transcriptase‐polymerase chain reaction (RT‐PCR) method. Changes in c‐myc gene expression were compared with DNA adduct formation, growth inhibition, and cell‐cycle progression as determined by 32P‐postlabelling, neutral red (NR), and flow cytometric analyses, respectively. None of the three test compounds altered the levels of 18S ribosomal RNA or β‐actin at the concentrations evaluated for c‐myc expression, indicating that nonspecific changes in gene expression induced by cytotoxicity, for example, were not present at the concentrations evaluated. Cells exposed to B[a]P exhibited a dose‐dependent increase in c‐myc expression; conversely, a dose‐dependent decrease in c‐myc expression was observed following BPDE exposure. A marginal but concentration‐dependent increase in c‐myc mRNA levels was observed following exposure to the K‐region epoxide. Our results demonstrated that, although B[a]P and its metabolites alter c‐myc expression, the parent compound and its metabolites produce unequal and contrasting effects on the expression of this gene. © 2004 Wiley‐Liss, Inc.