Miracle-dz/UniFAR-FTUs huggingface dataset:
Survey of stressful life events among diabetic and non-diabetic elderly individuals in Rafsanjan, Iran, in 2015

Received: April 2016, Accepted: June 2016 Background: Due to the increasing number of stressful life events among the elderly and the rapid spread of diabetes among them, the present study compared the stressful life events of diabetic elderly with those of non-diabetic elderly. Materials and Methods: This descriptive, cross-sectional study was conducted on 240 senior citizens of over 60 years of age (120 diabetic patients and 120 non-diabetics) of Rafsanjan, Iran. They were chosen through convenience sampling from among visitors of the Diabetes Clinic and Ali Ebne Abitaleb Laboratory in Rafsanjan. The data collection tool used was the questionnaire designed by Pickel et al. This questionnaire consists of two parts; one part is related to demographic information and the other to stressful life events. To analyze the data, Mann-Whitney test, chi-squared, Fisher’s exact test, and independent t-test were employed in SPSS software. Results: The frequency of psychological stresses caused by familial, personal, and environmental factors was higher among the diabetic elderly (P < 0.05). In addition, the frequency of psychological stresses caused by social stressful factors was higher among the non-diabetic elderly. The number of occupational-financial and environmental stressful factors was more among male diabetic patients, and the number of personal stressful factors was more among female patients (P < 0.05). The number of occupational-financial stressful factors was significantly higher among non-diabetic men than women (P < 0.05). Conclusions: According to the results, stressful factors play a major role in the onset of diabetes. By recognizing the sources of stress with the assistance of patients, and their family and medical team, effective steps can be taken to prevent and control its probable effects and side effects.
Dermal substitutes for full‐thickness wounds in a one‐stage grafting model

We tested different biodegradable matrix materials as dermal substitutes in a porcine wound model. Matrixes were covered with a split‐skin mesh graft and protected with a microporous, semipermeable membrane, which prevents blister formation, wound infection and provides ultimate healing conditions. Evaluation parameters were as follows: epithelization, dermal reconstitution, wound contraction, and cosmetic and functional aspect. A microfibrillar matrix of nondenatured collagen gave the best result, with immediate fibroblast ingrowth and epidermal outgrowth. Slight inflammatory reaction and minimal wound contraction were observed. Application of a split‐skin mesh graft, in combination with this collagen matrix, generated a thicker dermal layer than did a split‐skin mesh graft directly applied on a wound bed. However, the histologic dermal architecture was less optimal than one obtained with a full‐thickness punch graft method. Other matrixes caused inflammatory reactions, interfering with epithelization and dermal reconstitution. We conclude that a nondenatured collagen matrix, in combination with a split‐skin mesh graft, can provide a substitute dermis in a full‐thickness wound. This combination is preferable to a split‐skin mesh graft directly applied on the wound bed. With our microporous semipermeable membrane, the combined use of a dermal substitute and a split‐skin mesh graft can be applied in a single‐stage operation.
Acute Respiratory Diseases

and have used it in one case only. They regard failure of craniotomies to cure the condition as being due to the presence of severe atrophy of the brain and indicative of a bad prognosis. This volume can be recommended as an excellent summary of present knowledge of an important condition. There is a comprehensive bibliography covering English and Continental literature, which adds greatly to its value.
PENGARUH LIKUIDITAS, LEVERAGE, PROFITABILITAS, UKURAN PERUSAHAAN DAN CAPITAL INTENSITY TERHADAP AGRESIVITAS PAJAK PERUSAHAAN (Studi Empiris Pada Perusahaan Property dan Real Estate Yang Terdaftar di BEI Pada Tahun 2013-2015)

ABSTRACT This study aimed to examine the effect of liquidity, leverage, profitability, size of firm, capital intensity and aggressiveness against corporation tax. Independent variables used in this study liquidity, leverage, profitability, size of frm and capital intensity. While the dependent variable in this study was measured using the tax aggressiveness the measured using of the effective tax rate (ETR). The population in this study amounted to 49 companies Property and Real Estate listed on the Indonesia Stock Exchange (BEI) in the period 2013- 2015. Determination of the sample using purposive sampling method and obtained a sample of 33 companies Property and Real Estate based on certain criteria. The results showed that the profitability significant effect on the corporate tax aggressiveness. Meanwhile, liquidity, leverage, firm size and capital intensity does not significantly influence the aggressiveness of corporate taxes. Keywords: tax aggressiveness, leverage, profitability, capital intensity. ABSTRAK Penelitian ini bertujuan untuk menguji pengaruh likuiditas, leverage, profitabilitas ukuran perusahaan, dan capital intensity terhadap agresivitas pajak perusahaan. Variabel independen yang digunakan dalam penelitian ini likuiditas, leverage, profitabilitas ukuran perusahaan, dan capital intensity. Sedangkan variabel dependen dalam penelitian ini adalah agresivitas pajak yang diukur menggunakan ukuran effective tax rate (ETR). Populasi dalam penelitian ini berjumlah 49 perusahaan Property dan Real Estate yang terdaftar di Bursa Efek Indonesia (BEI) selama periode 2012-2013. Penentuan sampel penelitian menggunakan metode purposive sampling dan memperoleh sampel sebanyak 33 perusahaan Property dan Real Estate berdasarkan kriteria tertentu. Hasil penelitian menunjukkan bahwa Profitabilitas berpengaruh signifikan terhadap agresivitas pajak perusahaan. Sedangkan likuiditas, leverage, ukuran perusahaan dan capital intensity tidak berpengaruh signifikan terhadapagresivitas pajak perusahaan. Kata kunci : Agresivitas Pajak, leverage, profitabilitas, capital intensity.
A Review of Couple-Based Interventions for Enhancing Women’s Sexual Adjustment and Body Image After Cancer

Despite the growing interest in couple-based interventions for women with cancer, only few of these interventions primarily focus on improving women’s sexual and body image. A review of studies that investigated the impact of an intervention on women’s sexual adjustment and/or body image was conducted. Twelve studies met inclusion criteria for this review: 8 randomized control trials, 2 pilot randomized control trials, and 2 quasi-experimental designs. Our analysis revealed that interventions that produce stronger effects tend to be couple-focused and include treatment components that (1) educate both partners about the woman’s diagnosis and treatments, (2) promote couples’ mutual coping and support processes, and (3) include specific sexual therapy techniques to address sexual and body image concerns. Future intervention research should incorporate randomized, controlled clinical trial designs conducted according to the revised CONSORT (Consolidated Standards of Reporting Trials); include measures of body image, sexual satisfaction, and sexual dysfunction; have adequate statistical power; and include more diverse samples, especially women who are younger or from minority or less-educated groups.
Celling The Concept: A Study of Managerial Brand Mindsharing of A Distributed Biobanking Research Infrastructure

ABSTRACT This interview study investigates how managers/associates of a failed distributed large-scale Research Infrastructures perceived their brand and the role mindsharing played in light of the organisation’s ultimate failure. Specifically, the study looks at BioBanking and Molecular Resource Infrastructure in Sweden (BBMRI.se), an organisation that involved collaboration between several medical and technical universities and sought to harmonise biobanking in Sweden. The aim was to discern the respondents’ degree of mindsharing in regards to their perception of the organisational brand. The four stages the branding process investigated were: Brand Strategic Analysis, Brand Identity, Brand Operationalising, and Post-Implementation Reflections. The results indicated that the mindsharing was present at the initial two stages, but dissipated throughout the ensuing two final stages, resulting in a fragmented brand perception, thereby forgoing the ability of generating a “pull-effect” for the BBMRI.se brand. The study’s implication is for branding to account more for social and individual motivations and less for instrumental motivations, e.g. mission statements.
Submitted to Manufacturing & Service Operations Management manuscript Reveal the Supplier List ? A Trade-off in Capacity vs . Responsibility

Problem definition: Under what conditions and how can a buying firm, by committing to publish a list of its suppliers and/or the identities and violations of terminated suppliers, increase its expected profit and supplier responsibility? Academic / Practical Relevance: This paper contributes to a recent thrust in the OM literature on how various sorts of transparency influence social and environmental responsibility in a supply chain. In practice, companies are under pressure to publish their supplier lists and suppliers’ violations, and some are beginning to do so. This paper could help guide their decisions. Methodology: Game Theory Results: This paper shows how a buying firm can use transparency to reward a supplier for responsibility effort to eliminate social or environmental violations. By publishing its supplier list, the buying firm can signal that a supplier is responsible and generate profitable new business for the supplier. However, the resulting competition for the supplier’s scarce capacity could cause the buying firm to obtain fewer units or pay a higher price. We identify the conditions under which a buying firm should commit to publish its supplier list, and conditions under which the buying firm should also help a supplier with cost-reduction or capacity-expansion. In addition, the paper shows how a buying firm can use transparency to punish a supplier for a responsibility violationby warning other buying firms not to source from that supplier. Commitment to do so increases the supplier’s responsibility effort and can screen out a supplier with a known responsibility violation, thereby increasing a buying firm’s expected profit. If the supplier is uncertain whether or not it has a violation (e.g., faulty electrical wiring likely to cause a fire) then the two forms of transparency can be complementary. Managerial Implications: Buying firms should consider transparency as a potentially profitable approach to mitigating social and environmental violations in their supply chains.
Lighting the Darkness of Addiction: Can Phototherapy Enhance Contingency-Management-Based Treatment of Substance-Related and Addictive Disorders?

AbstractMaladaptive patterns of substance use are serious social problems. Both pharmacological and nonpharmacological treatments are available, but nondrug options may be preferable because they avoid the expense and adverse side effects of psychotropic medication. Contingency management (CM) and nondrug social and recreational activities (NDSRAs) are based on operant conditioning principles and seek to decrease substance use by means of nondrug rewards. However, their efficacy may be hindered where brain reward circuitry is dysfunctional. Research shows that substance abuse biases neural reward systems in favor of drug-induced highs, while disrupting circadian-based rhythms. Circadian systems also have been found to influence human reward pathways. Possibly, a bidirectional relationship exists between circadian disturbance and substance abuse effects. If so, repair of abnormal circadian rhythms might help normalize reward response in substance abusers, with positive effects on CM or NDSRA treatment outcomes. Phototherapy has been effective in repairing circadian rhythms in persons with seasonal affective disorder and other chronobiological conditions. This article proposes that it similarly may repair circadian response in substance abusers, thereby normalizing brain reward systems. By doing so, it would enhance the efficacy of CM and NDSRA therapies and may also help prevent relapse. Given its low cost and ease of administration, phototherapy seems a promising avenue to pursue.
FAKTOR-FAKTOR YANG MEMPENGARUHI KESUKSESAN SISTEM INFORMASI KEUANGAN DAERAH BERBASIS AKRUAL DI KABUPATEN ACEH BESAR

This study aims to look at the success rate of financial management informationsystem. The research variables consisted of information quality, system quality,service quality, user satisfaction, usage and net benefits. The population of thisstudy consists of all government unit of Banda Aceh and Aceh Besar district. Therespondents are users SIPKD namely officials financial manager, treasurer and treasurer reception. Sample selected by survey methods, which the entire population used as the research sample. Methods of data analysis using Structural Equation Modeling (SEM) with Lisrel 8.8 tools. The results using De Lone and McLean IS SuccessModel (2003) showed that out of 9 hypotheses constructed, 7 hypotheses show theeffect. Two other hypotheses do not show the influence that the quality system is touse and the quality of service to use. Overall SIPKD can be considered a success.
DEALING WITH IFRS 15: ANY IMPACT ON EARNINGS MANAGEMENT?FIRST EVIDENCES FROM ITALIAN LISTED COMPANIES.

A lot of studies show that the adoption of the IFRS reduces the level of earnings management (Rudra & Bhattacharjee, 2011; Cai et al., 2008;) and, consequently, decreases the use of discretionary accruals (Guenther et al., 2010). Nowadays, the major change in the IAS/IFRS’ panorama is represented by the adoption of IFRS 15 “Revenue from contracts with customers”, mandatory from 1st January 2018. From analysis done by the “Big-Four”, rise that this new principle will have a dissimilar impact, in view of the industries which each entity belongs, because the sectors are characterized by the different types of revenues. Conscious of that, to provide empirical evidence that earnings management is more frequent in some industries and low frequent in others, adopting a statistical analysis, it was observed a sample of Italian listed companies in the period 2001-2017. Specifically, it was chosen companies that belong two sectors: “Telecommunications” and “Utilities”. The Jones Model (1991) was applied. From the statistical analysis come to light that earnings management practices is “commonly adopted” in “Telecommunications” industry which is highly impacted by the introduction of IFRS 15. That said, the lesson learned from this study is that the implementation of the new principle, wrote to discipline the accountancy of revenues, and its consequences, must be carefully analyzed and monitored by the regulators, as well as correctly adopted by managers, as the determined revenues could have an impact on the pre-existing earning management practices.
The Influence of Physical Activity on Pain Thresholds in Patients With Depression and Multiple Somatoform Symptoms

Objectives:Pain is a common symptom with high occurrence in somatoform syndromes and depressive disorders. Research in this area often focuses on experimental induction of pain and subsequent assessment of pain thresholds, ensuring repeatable stimuli of defined quality. Results on sensitivity to experimental pain in major depression are inconclusive, and data on pain thresholds in multiple somatoform symptoms are scarce. The goals of the present study were to differentiate between groups regarding the pressure pain thresholds, and to investigate the possible influence of physical activity on the pain thresholds in these groups. We postulate that physical fitness and physical activity influence pain thresholds in depression and persons with multiple somatoform symptoms. Methods:Thirty-eight persons with major depression, 26 persons with a minimum of 6 to 8 somatoform symptoms (somatoform symptom index 8, SSI-8), and 47 healthy participants participated in the study. Baseline values of pressure pain thresholds assessed at different sites of the body were compared with those after 1 week of increased and 1 week of reduced physical activity. Results:We used repeated measurement design (MANCOVA) and partial correlations for data analysis. Depressed participants reported lower pain thresholds compared with controls, and persons with SSI-8 showed intermediate thresholds. After 1 week of physical activity, participants reported higher pain thresholds. Men had higher pain thresholds following activity as compared with women. Participants who reported higher general fitness also showed higher pain thresholds. Sensitivity to pressure pain is associated with depression, but not with multiple somatoform symptoms. Discussion:Short low-graded exercise can have reducing effects on perception of pressure pain. Physical activity level is a relevant covariate when using pressure pain assessment. Reduced general fitness can partially account for lower pain thresholds in depression.
Antioxidant activity of maillard reaction products from lysine-glucose model system as related to optical property and copper (II) binding ability

Maillard reaction (MR) was carried out in L-lysine-D-glucose (Lys-Glu) model system heated at 120°C for 0 to 10 h without pH control. Optical property (UV-Vis absorbance and fluorescence) development of MR was monitored. Antioxidant activity of maillard reaction products (MRPs) was investigated by a series of in vitro tests. The UV-Vis absorbance zero and first-order derivative spectrophotometric was utilized to study the metal-binding property and chelating effect of different fractions of MRPs. MRPs had reducing power, strong free radical-scavenging activity and copper (II)-binding ability. The antioxidant activity of MRPs related well with the UV-Vis absorbance properties of maillard rection. Cu2+-binding to MRPs caused the electronic rearrangement in UV-Vis absorbance intermediates, but had no effect on the chromophore structure in brown polymers. The UV-Vis absorbance compounds were responsible to the reducing power and radical-scavenging activity. The fractions of low molecular weight MRPs showed effective metal-chelating ability. Key words: Maillard reaction products, antioxidant activity, metal-chelating effect, optical properties.
Predictive Effect of XPA and XPD Polymorphisms on Survival of Advanced NSCLC Patients Treated with Platinum-Based Chemotherapy: A Three-Dimensional (3-D), Polyacrylamide Gel-Based DNA Microarray Method

Platinum-based chemotherapy is a primary treatment for patients with advanced non-small cell lung cancer (NSCLC). Considering individual differences, an effective and convenient method is urgently needed to identify the sensitivity of individual patient to platinum based regimen. Genetic variants in DNA repair genes are presumed to represent important determinants of drug efficacy. Our previous studies have demonstrated the involvement of xeroderma pigmentosum group A (XPA) codon23 and xeroderma pigmentosum group D (XPD) codon751 single-nucleotide polymorphisms (SNPs) in clinical response to platinum based chemotherapy in advanced NSCLC patients. Thus, a follow-up study was carried out to investigate the relevance of these genotypes and survival of the cohort (n = 115). The three-dimensional (3-D), polyacrylamide gel-based DNA microarray method was used to assess the genotypes of XPA and XPD in peripheral lymphocytes. Log-rank test revealed that the variant genotypes of XPA23 (A/G+G/G) were associated with significantly longer progression-free survival (PFS) (6.0 m vs. 10.6 m, log-rank P = 0.001) and overall survival (OS) (11.2 m vs. 20.8 m, log-rank P = 0.001). In Cox proportional hazards model, the hazard ratio (HR) for death in patients with G allele was 0.65 (P = 0.049). While no significant differences were observed in PFS or OS according to XPD Lys751Gln genotypes (log-rank P > 0.05). In combination with our previous short-term clinical results, this study further confirmed that by detecting the SNPs in blood cells, XPA A23G polymorphic variants might be a promising biomarker in predicting a favor prognosis of NSCLC patients and be helpful towards designing individualized treatments.
Antigen-induced IL-2 Production and Blastogenesis in PBMC from Tuberculosis Patients and Healthy Donors

Some patients with active tuberculosis lack a delayed skin test reaction to PPD (1-4). The basis for this immunologic hyporesponsiveness has been investigated using in vitro systems. Tuberculin-induced blastogenic responses of lymphocytes are decreased in such patients compared with healthy tuberculin reactors (5, 6). This is not simply due to a dearth of responsive cells in the circulation. Rather, monocytes act as antigen-specific suppressor cells in patients with pulmonary tuberculosis (5) and tuberculous pleurisy (8). FcTR + lymphocytes, i.e., cells bearing receptors for the Fc portion of IgG, also suppress PPD-induced blastogenesis in tuberculous patients (9). T cell proliferation is critically dependent on the lymphokine, IL-2 (10, 1 1). This hormone is a prerequisite for clonal expansion of antigen-specific T cells (12) and activation of the effector limb of cell-mediated immune responses (13, 14). IL-2-dependent cytotoxicity may be important for containment of facultative intracellular parasites such as Mycobacterium leprae (15) and Mycobacterium tuberculosis. We investigated IL-2 homeostasis in patients with active, newly diagnosed pulmonary tuberculosis. Depressed PPD-induced blastogenesis in these patients was associated with abnormalities in IL-2 production and IL-2-R generation restricted to the response to tuberculin PPD. In 10 of 22 patients, IL-2 generation was depressed and unaffected by adherent cell depletion; these patients showed more extensive disease by radiographic criteria. Dysregulation of production and response to the pivotal cytokine IL-2 thus may be critical factors in the defective cellular immune response in tuberculosis.