Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of unfractionated heparin and recombinant hirudin on survival in a sustained ovine endotoxin shock model

ObjectiveTo compare and evaluate the potential benefit of two different anticoagulation regimens during endotoxemia in an ovine model. DesignAnimal prospective randomized and controlled study following preliminary dose-range study conforming with the Guide for the Care and Use of Laboratory Animals as promulgated by the Council of the American Physiologic Society and reviewed by the Ethical Committee for Animal Research of our institution. SettingLaboratories of anesthesiological investigations and hemostasis, primary care university medical center. SubjectsTwenty-two adult sheep of either sex, weighing 29–42 kg (mean 35.8 kg), surgically instrumented for chronic studies and randomly allocated to receive three different treatment groups: unfractionated heparin (40 units·kg−1·hr−1; n = 7), recombinant hirudin (500 units·kg−1·hr−1; n = 7), or saline (nonanticoagulated controls; n = 8). InterventionsOvine model of severe endotoxin shock induced by a continuous intravenous Escherichia coli endotoxin infusion over 72 hrs (10 ng·kg−1·min−1). Measurements and Main ResultsEndotoxin infusion alone produced a progressive hypotensive, hyperdynamic shock state with right ventricle failure leading to the death of all animals of the control group within 44 hrs (median, 12 hrs). Heparin profoundly improved survival rate in this model, whereas effective anticoagulation with hirudin did not significantly increase the survival rate compared with controls. Animals in the control group died from disseminated intravascular coagulation, metabolic acidosis, and hemorrhagic pulmonary edema, whereas sheep treated with hirudin died from severe pulmonary edema (hypoxemia, increased alveoloarterial oxygen gradient associated with an increased wet/dry lung weight ratio) in the absence of disseminated intravascular coagulation. ConclusionsWe conclude that systemic anticoagulation with the thrombin inhibitor hirudin is without benefit in this sheep model of lethal endotoxemia, whereas anticoagulation with heparin affords not only effective prevention of endotoxin-induced coagulation disorders but also global protection with prevention of respiratory decompensation and thus markedly improves survival rate in this situation.
Content-extraction-based compression of acceleration data for mobile wireless sensors

A content-extraction based acceleration data compression algorithm is proposed for real-time transport quality monitoring in critical logistics applications. It splits the original data into three components, Tilt, Shock and Vibration, and compresses them separately by making use of the specific characteristics. Outstanding performances as well as low complexity and good scalability are achieved, which are essential for resource-constrained mobile wireless sensors. The algorithm has been proven by 46-day field test data. The compression ratio is up to 3.75 in loss-less mode, and up to 142 in lossy mode with 28.9dB SNR.
Pair programming in education: a literature review

This article provides a review of educational research literature focused on pair programming in the undergraduate computer science curriculum. Research suggests that the benefits of pair programming include increased success rates in introductory courses, increased retention in the major, higher quality software, higher student confidence in solutions, and improvement in learning outcomes. Moreover, there is some evidence that women, in particular, benefit from pair programming. The literature also provides evidence that the transition from paired to solo programming is easy for students. The greatest challenges for paired students appear to concern scheduling and partner compatibility. This review also considers practical issues such as assigning partners, teaching students to work in pairs, and assessing individual contributions, and concludes with a discussion of open research questions.
Optimizing Compilers for Modern Architectures: A Dependence-based Approach

Modern computer architectures designed with high-performance microprocessors offer tremendous potential gains in performance over previous designs. Yet their very complexity makes it increasingly difficult to produce efficient code and to realize their full potential. This landmark text from two leaders in the field focuses on the pivotal role that compilers can play in addressing this critical issue. The basis for all the methods presented in this book is data dependence, a fundamental compiler analysis tool for optimizing programs on high-performance microprocessors and parallel architectures. It enables compiler designers to write compilers that automatically transform simple, sequential programs into forms that can exploit special features of these modern architectures. The text provides a broad introduction to data dependence, to the many transformation strategies it supports, and to its applications to important optimization problems such as parallelization, compiler memory hierarchy management, and instruction scheduling. The authors demonstrate the importance and wide applicability of dependence-based compiler optimizations and give the compiler writer the basics needed to understand and implement them. They also offer cookbook explanations for transforming applications by hand to computational scientists and engineers who are driven to obtain the best possible performance of their complex applications.
Do children's attention processes mediate the link between family predictors and school readiness?

The role of attention processes as possible mediators between family environment and school readiness was analyzed with data from 1,002 children and their families. Data on children's sustained attention, impulsivity, and school readiness (i.e., cognitive, achievement, language, and social development) were obtained at 54 months of age, and quality of the family environment was assessed throughout the first 54 months. Mediation tests showed that children's sustained attention partially accounted for the link between family environment and achievement and language outcomes. Impulsivity partially accounted for the link between family environment and achievement, social competence, and externalizing behaviors. The roles of sustained attention and of inhibition of impulsive responding in the relation between family characteristics and school readiness are discussed.
Ionization and scintillation response of high-pressure xenon gas to alpha particles

High-pressure xenon gas is an attractive detection medium for a variety of applications in fundamental and applied physics. In this paper we study the ionization and scintillation detection properties of xenon gas at 10 bar pressure. For this purpose, we use a source of alpha particles in the NEXT-DEMO time projection chamber, the large scale prototype of the NEXT-100 neutrinoless double beta decay experiment, in three different drift electric field configurations. We measure the ionization electron drift velocity and longitudinal diffusion, and compare our results to expectations based on available electron scattering cross sections on pure xenon. In addition, two types of measurements addressing the connection between the ionization and scintillation yields are performed. On the one hand we observe, for the first time in xenon gas, large event-by-event correlated fluctuations between the ionization and scintillation signals, similar to that already observed in liquid xenon. On the other hand, we study the field dependence of the average scintillation and ionization yields. Both types of measurements may shed light on the mechanism of electron-ion recombination in xenon gas for highly-ionizing particles. Finally, by comparing the response of alpha particles and electrons in NEXT-DEMO, we find no evidence for quenching of the primary scintillation light produced by alpha particles in the xenon gas.
Light-dependent carotenoid synthesis in the tomato fruit.

can therefore be used either alone, when it is desirable to estimate the lysine and arginine content of a given protein sample, or in conjunction with other procedures when the complete amino acid composition of protein is in question, but an accurate assessment of the lysine level is important such as in animal experiments related to the study of lysine deficiency. The method may also find use in agricultural research laboratories devoted to the development of high lysine wheat and rice varieties.
Duration of Dentinal Tubule Occlusion Formed by Calcium Phosphate Precipitation Method: In vitro Evaluation Using Synthetic Saliva

The use of a calcium phosphate precipitation method occluded dentin tubules with apatitic mineral and, thus, showed good potential for the treatment of dentin hypersensitivity. The aim of this study was to elucidate the occluding behavior of the precipitate in the oral environment. Dentin disks treated by the calcium phosphate precipitation method, and disks treated with potassium oxalate, NaF, and SrCl2 solutions, were immersed in synthetic saliva, which was regularly replenished so that ionic concentration would be maintained. Treatment of dentin disks by the calcium phosphate precipitation method immediately reduced dentin permeability to 6 ± 8%. When the disk was immersed in synthetic saliva, dentin permeability remained low, even seven days after immersion. Scanning electron microscopic observation showed no distinct boundary line between the precipitate and intertubular dentin; this indicated further mineralization on the precipitate. Potassium oxalate treatment also reduced the dentin permeability to 8 ± 3%. However, the dentin permeability gradually but steadily increased with immersion time, reaching 39 ± 14% at seven days. To elucidate the mechanism underlying dentin permeability changes in synthetic saliva, we immersed the precipitates, i.e., apatitic mineral and calcium oxalate, in a fixed volume of synthetic saliva. When calcium oxalate was immersed in synthetic saliva, there was a large concentration of oxalate ions, indicating dissolution of the calcium oxalate; this phenomenon was ascribed to the increase in dentin permeability. In contrast, calcium and phosphate ions decreased when apatitic powder, the precipitate formed by the calcium phosphate precipitation method, was immersed in synthetic saliva. The decrease in the calcium and phosphate ions in synthetic saliva indicated further precipitation of calcium phosphate on the apatitic precipitate. We concluded, therefore, that the calcium phosphate precipitation method would have a continuous effect in reducing dentin permeability in the oral environment.
Incorporating Comment Text into Success Prediction of Crowdfunding Campaigns

In recent years, crowdfunding has increasingly become an important financing alternative of raising startup funds. To date, drawing upon Kickstarter’ Statistics, merely 35.79% of the crowdfunding campaigns can achieve their initial funding goal to successfully launch their projects. Previous studies have explored several determinants of crowdfunding success including the early stage of funding, project duration, categories and social networks. However, dynamic features such as project comments and updates are yet to be systematically studied. In this work, we propose a method to extract important features from backers’ comments and creators’ updates in different periods of project duration to predict the crowdfunding success. Experimental results show that incorporating dynamic features from backers’ comments and creators’ updates increases the accuracy of success prediction. Sentiment and textual quality features derived from project comments further boost the prediction accuracy. In addition, our research reveals the significant factors from comments and updates to improve the success rate of crowdfunding campaigns, which could be beneficial to the project creators.
[O III] profile substructure in radio-quiet quasars

Interactions between the radio jet and the optical emission of the narrow-line region (NLR) are a well known phenomenon in Seyfert galaxies. Here, we present the study of possible jet-NLR interactions in five radio-quiet PG quasars with double or triple radio structure. High spatial and spectral resolution observations were carried out in the Hβ-[O III] λ5007 wavelength range. In all cases, there is evidence for [O III] profile substructure (shoulders, subpeaks, blueshifted "broad" components) with different clarity. To measure the velocity, line width, intensity, and location of these [O III] components, several Gaussians were fitted. Often, the substructures are more pronounced close to the radio lobes, suggestive of jet-NLR interactions. Our observations support the unification scheme in which radio-quiet quasars are assumed to be the luminous cousins of Seyfert galaxies.
Subacromial Impingement: Is there Correlation between Symptoms, Arthroscopic Findings and Outcomes?

Background To determine whether a correlation exists between the clinical symptoms and signs of impingement, and the severity of the lesions seen at bursoscopy. Methods Fifty-five patients who underwent arthroscopic subacromial decompression were analyzed. Pre-operatively patients completed an assessment form consisting of visual analogue pain score, and shoulder satisfaction. The degree of clinical impingement was also recorded. At arthroscopy impingement was classified according to the Copeland-Levy classification. Post-operatively the shoulder assessment was repeated. Statistical analysis was carried to determine if the degree of impingement at arthroscopy correlated with pre-operative pain, satisfaction and clinical signs of impingement. Results Pre-operative pain level, shoulder satisfaction and degree of clinical impingement did not correlate significantly with severity of the lesions of the acromion and cuff. (average correlation coefficient r2 0.018.) There was no correlation between the improvement in the shoulders post-operatively and the severity of lesions (r2 0.008). Conclusion There was no correlation between pain, clinical signs or outcomes of subacromial decompression and the severity of impingement lesions seen at arthroscopy.
Cardiac Resynchronization Therapy in Patients With Intrinsic and Right Ventricular Pacing-Induced Left Bundle Branch Block Pattern

We studied 95 consecutive patients, mean age 70 years, who received cardiac resynchronization therapy (CRT) for class III or IV heart failure with a left ventricular (LV) ejection fraction ≤35% and a QRS duration ≥120 ms. Sixty-seven patients had intrinsic left bundle branch block (LBBB) (group 1), and 28 patients had right ventricular pacing-induced LBBB (group 2). The time difference (TPW-TDI) between onset of QRS to the end of LV ejection by pulsed wave Doppler and onset of QRS to the end of systolic wave in the basal segment with greatest delay by tissue Doppler imaging was measured before CRT and at the last follow-up after CRT. TPW-TDI >50 ms was defined as left ventricular mechanical dyssynchrony. A positive response to CRT was defined as LV volume at end-systole decreasing ≥15% after CRT. The percentage of CRT responders in group 2 was significantly greater than that in group 1 (68% versus 42%, P = 0.04) during follow-up of 16 months. After adjusting for age, gender, and clinical features, this pattern of CRT response persisted (P = 0.008). Similarly, there was a greater reduction in QRS duration in group 2 (178 ms) after CRT versus 154 ms for group 1, P = 0.01. There was no significant difference in TPW-TDI between the 2 groups at baseline or at follow-up. There was no significant difference in mortality (15% versus 14%) and Kaplan-Meier survival plot during follow-up. Patients with heart failure and right ventricular pacing-induced LBBB have a better response rate to CRT than patients with intrinsic LBBB. The change in left ventricular mechanical dyssynchrony after CRT was similar in these 2 groups of patients.
LOCATION OF FAILURE PLANE AND DESIGN CONSIDERATIONS FOR NARROW GEOSYNTHETIC REINFORCED SOIL WALL SYSTEMS

The design of a Geosynthetic Reinforced Soil (GRS) wall for internal stability against pullout failure requires computing the reinforcement embedment length. Therefore, the location of failure plane is an important input for this design. The current FHWA MSE wall design guidelines assume the location of failure plane based on Rankine theory. While this assumption holds true for conventional walls it is unconservative for GRS walls under constrained spaces, also known as “narrow GRS walls”. This paper presents a limit equilibrium study to accurately locate failure planes within narrow GRS walls. The critical failure planes within narrow GRS walls are searched using Spencer’s method with a function of noncircular failure plane. The predicted results from limit equilibrium analyses are verified by the experimental data from centrifuge tests conducted on narrow GRS walls. The results indicate that the critical failure plane is bilinear: The failure surface being formed partially through the reinforced soil and partially along the interface between the GRS and the stable wall face. The results show the inclination angles of the failure planes for narrow GRS walls being 10~ 20 less than those calculated by Rankine theory. The effect of wall aspect ratio on the inclination angle of the critical failure plane is investigated for the cases studied in this paper. Design considerations against pullout failure for narrow GRS walls are also discussed at end of this paper.
Aerosol delivery to intubated patients

Introduction: Approximately 20 million patients are intubated in the USA each year, primarily for the administration of drugs. While the vast majority of these medications are administered as gas or instilled, there is a growing practice of aerosol administration to intubated patients, often associated with mechanical ventilation. As no drugs have been approved for aerosol administration to intubated infants or adults, much of these practices are technically off-label. Areas covered: History and advances in aerosol delivery with methods to determine delivery, with variables that impact delivery and the evolution of new technology and techniques. A literature search was undertaken using several databases including Cochrane, PubMed, Medline, Cinahl and Science Direct, covered materials from 1885 through January 2013. Expert opinion: As aerosol deposition has increased with newer technologies from 1 – 3% up to 30 – 60%, there exists an opportunity to develop drugs to better treat these sickest of patients and address the current unmet medical need.
Disseminated Intravascular Coagulation in Trauma Patients

Disseminated intravascular coagulation (DIC) is characterized by the in vivo activation of the coagulation system, which results in the intravascular deposition of fibrin and consumption bleeding. DIC is a serious hemostatic complication of trauma. It can be clearly distinguished from physiological hemostatic response to trauma by using sensitive coagulofibrinolytic molecular markers. Physiological hemostasis to injuries is similar in all kinds of trauma without exception. There is an increase in circulating proinflammatory cytokines in DIC patients after trauma. Elevated cytokines induce tissue factor-mediated activation of coagulation, suppression of the anticoagulant pathway, and plasminogen activator inhibitor-1 (PAI-1)-mediated inhibition of fibrinolysis followed by disseminated fibrin deposition in the microvasculature. In addition to the occlusive microvascular thrombosis and hypoxia, sustained systemic inflammatory response characterized by neutrophil activation and endothelial damage plays a pivotal role in the development of multiple organ dysfunction syndrome (MODS) in posttrauma DIC patients. DIC associated with sustained systemic inflammatory response syndrome (SIRS) after trauma leads to the development of MODS, which is the main determinant of patients' outcome after trauma.
Design of High-Q Tunable SIW Resonator and Its Application to Low Phase Noise VCO

In this letter, a low-cost continuously tunable substrate integrated waveguide (SIW) resonator and a low phase noise SIW voltage-controlled oscillator (VCO) are presented. A simple new structure for coupling varactor to the SIW cavity is proposed, which realizes a simple circuit layout for the tuning resonator. Equivalent circuit model is given for the varactor coupled resonator. Relation between the coupling coefficient and the relative tuning bandwidth is analyzed. Prototypes of tunable SIW resonator and a low phase noise SIW VCO have been designed and fabricated. Measured results show that the proposed resonator possesses unloaded Q factor of 286-299 for a tuning range of 492 MHz, and the phase noise of the SIW VCO is -93 --95.6 dBc/Hz at 100 kHz offset for the whole oscillating frequency range of 455 MHz at X-Band.
Dreaming during anaesthesia in patients at high risk of awareness

Dreaming during anaesthesia is commonly reported but remains poorly understood. In this study, adult surgical patients at high risk of awareness were randomly assigned to receive bispectral index (BIS)‐guided anaesthesia or routine care, and were interviewed about dreaming three times postoperatively. Dreaming patients (n = 134) were compared with all other patients who were interviewed at least once (n = 2251). Intraoperative dreaming was reported by 4.2%, 3.9% and 3.4% of patients at 2–4 h, 24–36 h and 30 days after surgery, respectively. Fewer BIS‐monitored patients reported intra‐operative dreaming at 2–4 h than control patients (2.7% vs. 5.7%; p = 0.004). Reports of dreaming were similar in the two groups at 24–36 h and 30 days. Dreaming patients were younger (p = 0.001); healthier (p < 0.001) and more likely to be women (p < 0.001), and were less satisfied with anaesthetic care (p = 0.004) than other patients.
The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies.

AIMS To obtain estimates of the efficacy and safety of pre-operative aspirin in patients undergoing coronary artery bypass grafting (CABG). METHODS AND RESULTS Eligible studies included randomized controlled trials (RCTs) and observational studies of patients undergoing CABG, comparing pre-operative aspirin with no aspirin/placebo, and reporting at least one of our primary outcomes. In eight RCTs (n = 805), pre-operative aspirin increased post-operative bleeding [Mean difference (MD), 104.9 mL; 95% confidence interval (CI), 19.2-190.6; P = 0.016] and reoperation [odds ratio (OR), 2.52; 95% CI, 1.18-5.38; P = 0.017), but not transfusion requirements (MD, 0.62 units; 95% CI, -0.06-1.30; P = 0.072). Subgroup analysis suggested that bleeding was increased with aspirin doses > or =325 mg/day, but not with lower doses. In 14 observational studies (n = 4485), pre-operative aspirin increased post-operative bleeding (MD, 113.6 mL; 95% CI, 45.2-182.0; P = 0.001) and transfusion requirements (MD, 0.34; 95% CI, 0.12-0.56 units; P = 0.002), but not reoperation (OR, 1.12; 95% CI, 0.69-1.83; P = 0.647). Neither analysis detected a significant effect on myocardial infarction or death. CONCLUSION Pre-operative aspirin increases post-operative bleeding, but this may be avoided by the use of aspirin doses <325 mg/day. Most of the RCTs are old and the meta-analysis was underpowered for efficacy outcomes. A large randomized trial is necessary to determine the safety and efficacy of pre-operative aspirin in the setting of contemporary cardiac surgical practice.