Miracle-dz/UniFAR-FTUs huggingface dataset:
Human TROP‐2 is a tumor‐associated calcium signal transducer

Trop‐2/EGP‐1/GA733‐1 is a recently identified cell surface glycoprotein highly expressed by human carcinomas. The cytoplasmic tail of Trop‐2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl‐inositol binding consensus sequence. Thus, we investigated whether Trop‐2 might be a functional signaling molecule. Using the fluorescent probe Fura‐2, we assayed the cytoplasmic calcium levels in human cancer cells stimulated with anti‐Trop‐2 or control antibodies. Three anti‐Trop‐2 MAbs, Rs7‐7G11, MOv16 and 162‐46.2 specifically induced a transient intracellular calcium level increment in up to 40% of the experiments performed. Polyclonal antisera recognizing recombinant Trop‐2 molecules possessed a much lower stimulation efficiency. The average latency of antibody‐induced Ca2+ rise for OvCa‐432 cells was 64 ± 26 sec. Internal Ca2+ concentrations reached peaks of 190 ± 24 nM vs<0R>. basal levels of 61 ± 4 nM and returned to baseline within 193 ± 37 sec. Similar values were obtained in MCF‐7 cells. For comparison, stimulation of P2‐purinergic receptors on MCF‐7 and OvCa‐432 cells induced a Ca2+ rise in most cases, leading to average internal Ca2+ concentrations of 297 ± 41 and 391 ± 39 nM, respectively. Our findings show that Trop‐2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. Int. J. Cancer 76:671–676, 1998. © 1998 Wiley‐Liss, Inc.
Amniotic Membrane Transplantation in Trabeculectomy With Mitomycin C for Refractory Glaucoma

PurposeTo compare outcomes of trabeculectomy combined with mitomycin C (MMC) and amniotic membrane transplantation (AMT) with those of trabeculectomy with MMC alone in refractory glaucoma. MethodsThis prospective, randomized study included 37 eyes with refractory glaucoma at such high risks as neovascular, pseudophakic, and prior failure. Trabeculectomy with MMC and single-layer AMT under the scleral flap was performed in 19 eyes and trabeculectomy with MMC alone in 18 eyes. The outcome measures included intraocular pressure (IOP), number of antiglaucoma medications, and complications. All patients were followed for 12 months. ResultsComplete success (IOP <22 mm Hg without glaucoma medications) was seen in 15/16 (93.7%) study eyes and 9/15 (60%) control eyes at 6 months postoperatively (P=0.03), and in 12/15 (80%) and 6/15 (40%) at 12 months after surgery, respectively (P=0.03). IOP decreased from 45.6±12.7 mm Hg and 44.9±10.7 mm Hg preoperatively in study and control groups to 15.3±2.3 mm Hg and 21.3±3.8 mm Hg, respectively, at 12 months (P<0.0001). Early postoperative hypotony developed in 3 (16.7%) control eyes owing to excessive filtration but none of study eyes (P=0.1). Encapsulated bleb occurred in 7 (38.9%) control eyes but in 1 (5.3%) study eye (P=0.02). ConclusionsIn refractory glaucoma, trabeculectomy combined with MMC and AMT compared to trabeculectomy with MMC alone has higher success rates, lower postoperative mean IOPs, and less complication rates.
Management of Uncomplicated Nail Bed Lacerations Presenting to a Children's Emergency Department

Objective: This study examined the mechanisms of injury and the pattern of care for children who presented to the emergency department with uncomplicated nail bed lacerations. Methods: A retrospective chart review was conducted from January 2004 to December 2007 for all children younger than 18 years who presented to a tertiary children's hospital with an uncomplicated nail bed laceration. Results: There were 84 cases of uncomplicated nail bed injuries for more than a 4-year period. Sixty percent of the subjects were males. The mean age was 5.3 (SD, 4.1) years. Most injuries occurred at home (58%), and the most common mechanism of injury was a door (67%). Approximately 40% of patients were treated by emergency physicians. There was no significant difference in acute and chronic complications or in the length of stay in the emergency department, between patients treated by emergency physicians and by plastic surgeons. Conclusions: Most nail bed injuries in children occur at home, and the door seems to be the major mechanism of injury. Approximately 57% of these are children younger than 5 years. Only 42% of uncomplicated nail bed lacerations are treated by emergency physicians, yet there is no significant difference in outcomes between plastic surgeons and emergency physicians. Our study suggests that there is a role in public education for primary prevention, and with proper training, pediatric emergency physicians can treat uncomplicated nail bed lacerations.
A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture.

The colonization of the rodent gastrointestinal tract by enteric neuron precursors is controversial due to the lack of specific cellular markers at early stages. The transcription factor, Phox2b, is expressed by enteric neuron precursors (Pattyn et al. Development 124, 4065-4075, 1997). In this study, we have used an antiserum to Phox2b to characterize in detail the spatiotemporal expression of Phox2b in the gastrointestinal tract of adult mice and embryonic mice and rats. In adult mice, all enteric neurons (labeled with neuron-specific enolase antibodies), and a subpopulation of glial cells (labeled with GFAP antibodies), showed immunoreactivity to Phox2b. In embryonic mice, the appearance of Phox2b-immunoreactive cells was mapped during development of the gastrointestinal tract. At Embryonic Days 9.5-10 (E9.5-10), Phox2b-labeled cells were present only in the stomach, and during subsequent development, labeled cells appeared as a single rostrocaudal wave along the gastrointestinal tract; at E14 Phox2b-labeled cells were present along the entire length of the gastrointestinal tract. Ret and p75 have also been reported to label migratory-stage enteric neuron precursors. A unidirectional, rostral-to-caudal colonization of the gastrointestinal tract of embryonic mice by Ret- and p75-immunoreactive cells was also observed, and the locations of Ret- and p75-positive cells within the gut were very similar to that of Phox2b-positive cells. To verify the location of enteric neuron precursors within the gut, explants from spatiotemporally defined regions of embryonic intestine, 0.3-3 mm long, were grown in the kidney subcapsular space, or in catenary organ culture, and examined for the presence of neurons. The location and sequence of appearance of enteric neuron precursors deduced from the explants grown under the kidney capsule or in organ culture was very similar to that seen with the Phox2b, Ret, and p75 antisera. Previous studies have mapped the rostrocaudal colonization of the rat intestine by enteric neuron precursors using HNK-1 as a marker. In the current study, all HNK-1-labeled cells in the gastrointestinal tract of rat embryos showed immunoreactivity to Phox2b, but HNK-1 cells comprised only a small subpopulation of the Phox2b-labeled cells. In addition, in rats, Phox2b-labeled cells were present in advance of (more caudal to) the most caudal HNK-1-labeled cells by 600-700 microm in the hindgut at E15. We conclude that the neural crest cell population that arises from the vagal level of the neural axis and that populates the stomach, midgut, and hindgut expresses Phox2b, Ret, and p75. In contrast, the sacral-level neural crest cells that populate the hindgut either do not express, or show a delayed expression of, all of the known markers of vagal- and trunk-level neural crest cells.
TLR Ligands Act Directly upon T Cells to Restore Proliferation in the Absence of Protein Kinase C-θ Signaling and Promote Autoimmune Myocarditis1

The serine/threonine kinase, protein kinase C-θ (PKC-θ), plays a central role in the activation and differentiation of Th2 cells while being redundant in CD4+ and CD8+ antiviral responses. Recent evidence indicates that PKC-θ may however be required for some T cell-driven autoimmune responses. We have investigated the role of PKC-θ in the induction of autoimmune myocarditis induced by either Coxsackie B3 virus infection or immunization with α-myosin/CFA (experimental autoimmune myocarditis (EAM)). PKC-θ-deficient mice did not develop EAM as shown by impaired inflammatory cell infiltration into the heart, reduced CD4+ T cell IL-17 production, and the absence of a myosin-specific Ab response. Comparatively, PKC-θ was not essential for both early and late-phase Coxsackie virus-induced myocarditis. We sought to find alternate pathways of immune stimulation that might reconcile the differential requirements for PKC-θ in these two disease models. We found systemic administration of the TLR ligand CpG restored EAM in PKC-θ-deficient mice. CpG could act directly upon TLR9-expressing T cells to restore proliferation and up-regulation of Bcl-xL, but exogenous IL-6 and TGF-β was required for Th17 cell differentiation. Taken together, these results indicate that TLR-mediated activation of T cells can directly overcome the requirement for PKC-θ signaling and, combined with the dendritic cell-derived cytokine milieu, can promote the development of autoimmunity.
Lightweight Attentional Feature Fusion for Video Retrieval by Text

In this paper we revisit feature fusion , an old-fashioned topic, in the new context of video retrieval by text. Different from previous research that considers feature fusion only at one end, let it be video or text, we aim for feature fusion for both ends within a uniﬁed framework. We hypothesize that optimizing the convex combination of the features is preferred to modeling their correlations by computationally heavy multi-head self attention. Accordingly, we propose Lightweight Attentional Feature Fusion (LAFF). LAFF performs feature fusion at both early and late stages and at both video and text ends, making it a powerful method for exploiting diverse (off-the-shelf) features. Extensive experiments on four public datasets, i.e . MSR-VTT, MSVD, TGIF, VATEX, and the large-scale TRECVID AVS benchmark evaluations (2016-2020) show the viability of LAFF. Moreover, LAFF is extremely simple to implement, making it appealing for real-world deployment.
Islet Size Index as a Predictor of Outcomes in Clinical Islet Autotransplantation

Background The islet size distribution in a preparation may contribute to islet transplant outcomes. At the same islet equivalent (IE) dose, larger islets may exhibit poorer therapeutic value and this may be because of oxygen diffusion limitations that worsen in proportion to islet size. Methods To test this hypothesis, we studied the impact of islet size index (ISI) and other islet product characteristics on outcomes after islet autotransplant (IAT) in recipients receiving a marginal islet dose (2000–4999 IEs per kg body weight) from January 1, 2009 to June 11, 2012, at the University of Minnesota (n=58). ISI was defined as the number of IE divided by the number of islet particles (IPs) in a preparation; an ISI less than 1 indicates a mean islet diameter that is less than 150 &mgr;m. The primary post-IAT outcome was 6-month insulin use status. Results Logistic regression analysis indicate that IPs/kg (P=0.001), IEs/kg (P=0.019), total IPs transplanted (P=0.040), and ISI (P=0.074) were most strongly correlated with the primary outcome. The ISI (mean±standard error) was lower for recipients achieving insulin independence at 6 months (0.71±0.05) versus those partially (0.83±0.05) or completely (1.00±0.07) insulin dependent. The combination of islet dose (expressed as units IPs/kg) and ISI exhibited a sensitivity of 75% and specificity of 74% in predicting insulin independence in this population of patients. Conclusion Islet autotransplant recipients of a marginal islet doses were more likely to achieve insulin independence when transplanted with a greater number of smaller islets.
Research, teaching, and ‘other’: what determines job placement of economics Ph.D.s?

ABSTRACT This article examines job placement for Economics Ph.D.s seeking junior-level positions using a data set constructed from job candidate vitas, public websites, and queries to programme directors. Based upon multinomial logit estimation, being from highly ranked graduate institutions and having high quality publications has a significantly positive effect on placement at a top 20 academic institution or Doctoral-level institution. Teaching experience – as a teaching assistant (TA) or independent instructor – has a significantly positive effect on placement, but only for institutions ranked below the top 60, Masters and Baccalaureate institutions, and non-tenure track academic positions. We find little evidence on the effect of teaching in tenure track hires for departments with Doctoral programmes or mid-tier prestige. Moreover, teaching experience has a significantly negative effect on placement in the top group of academic institutions in Economics.
Patterns of dye coupling in lumbar motor nuclei of the rat

Gap junctions exist on motoneurons of the spinal nucleus of the bulbocavernosus (SNB) and the dorsolateral nucleus (DLN), both sexually dimorphic motor nuclei in the lumbar spinal cord of the rat. In addition, messenger RNA for gap junction proteins is expressed in motoneurons of the retrodorsolateral nucleus (RDLN), a nondimorphic spinal motor nucleus that innervates a muscle of the foot. Gap junctions on SNB and DLN motoneurons are androgen sensitive; the number and size of gap junctions decrease following castration, a change that can be reversed with exogenous testosterone replacement. In contrast, RDLN gap junction mRNA levels remain constant throughout hormone manipulation. In this study, dye coupling was used to examine patterns of gap junction‐mediated connectivity in these three lumbar spinal motor nuclei. Injection of dye into single motoneurons resulted in spatially extensive labeling of neighboring cells in all three nuclei; significantly more coupling was observed in the sexually dimorphic nuclei than in the RDLN. Dye‐coupled clusters of cells included motoneurons and interneurons; coupling was bilateral in the SNB. Treatment with oleamide, a gap junction blocker, completely attenuated labeling. In all nuclei, androgen manipulation did not alter the number, identity, or distribution of coupled cells. Thus, sexually dimorphic nuclei in the spinal cord exhibit greater dye coupling than do nondimorphic populations, and the patterns of connectivity are insensitive to androgen despite modification of their number and size. J. Comp. Neurol. 454:34–41, 2002. © 2002 Wiley‐Liss, Inc.
Ten Years of Sustainability (2009 to 2018): A Bibliometric Overview

Sustainability (SUS) is a journal in the field of environmental, cultural, economic and social sustainability of human beings and civilization, which was founded in 2009. This paper provides a comprehensive bibliometric overview of the journal and 6459 publications from 2009 to 2018. In the paper, we first introduce the materials and methods used. Next, we provide the bibliometric results in four parts. In the first part, we present the publication structure and citation structure of SUS, including annual trends of publications and citations, sources that cite SUS publications, and the most highly cited papers in SUS. The primary influential countries and institutes as well as their co-authorship networks are illustrated in the second part. The co-citation networks of cited references, journals and authors are shown in the third part. Finally, the co-occurrence network of keywords and bursting citation keywords is detected. VOSviewer and CiteSpace software packages are used for graphical visualization.
Disease Activity Related Catecholamine Response of Lymphocytes from Patients with Rheumatoid Arthritis

ABSTRACT: In patients with chronic rheumatic diseases, a decreased density of β2‐adrenergic receptors (β2R) on peripheral blood mononuclear cells (PBMC) could be demonstrated negatively correlating with various disease activity parameters. The aim of the present study was to determine the impact of this decrease on catecholamine response of PBMC from patients with rheumatoid arthritis (RA) in vitro. PBMC from 17 patients with RA and 6 healthy blood donors (HD) were investigated. The effects of epinephrine (E) and norepinephrine (NE) on PBMC proliferation were studied using cells activated with phytohemagglutinin (PHA) and monoclonal anti‐CD3‐antibodies (OKT3), respectively. The results revealed that lymphocytes of patients with RA showed a significantly reduced influence of catecholamines on PBMC function. In RA patients with high disease activity only, a shift to α1‐adrenergic‐mediated catecholamine effects upon PBMC reactivity could be observed. The study demonstrates the intricate relationship between PBMC reactivity and catecholamine effects that is mediated via α‐ and β‐adrenergic receptors due to disease activity. In this respect the altered catecholamine response of PBMC from patients with RA may contribute to the pathogenic process of RA.
Economic Growth from the Household Perspective: GDP and Income Distribution Developments Across OECD Countries

This paper provides an assessment of how households’ income has fared compared with GDP. While the prime focus is on incomes around the median, attention is paid also to the bottom of the income distribution. Thus, one contribution of the paper is to deliver a fresh assessment of the evolution of inequality and poverty across OECD countries over the last fifteen years. The analysis relies on a rich array of indicators, producing new evidence of the various patterns of differences in income distributions across countries and over time. For example, it assesses the extent to which stability in overall income inequality masks compensating changes between the lower and upper halves of the income distribution. Also, it explores whether contracting inequalities coexist with increasing poverty. The paper adds to previous studies by introducing, measuring and analysing income polarisation in a cross-country comparative perspective. Distinguishing polarisation from inequality and comparing their evolution over time provides new policy-relevant perspectives on the nature of the changing income distribution. La croissance du point de vue des menages : PIB et distribution des revenus dans les pays de l'OCDE Cet article analyse les evolutions des revenus des menages en comparaison avec celles du produit interieur brut (PIB). L’analyse se concentre sur les revenus proches de la mediane, mais une attention particuliere est egalement portee aux bas revenus. Ainsi, une des contributions de ce rapport est de degager un nouveau diagnostic de l’evolution des inegalites et de la pauvrete au cours des quinze dernieres annees dans les pays de l’OCDE. L’analyse repose sur un ensemble riche d’indicateurs, et produit une description fine de la nature des differences de distribution du revenu entre pays et au cours du temps. Par exemple, l’article montre qu’un niveau stable de l’inegalite dans son ensemble peut masquer des changements en sens inverse et qui se compensent entre la moitie haute et la moitie basse de la distribution. Aussi, l’article explore la possibilite que la reduction des inegalites puisse s’accompagner d’une hausse de la pauvrete. L’analyse etend les etudes precedentes en introduisant, mesurant et analysant la polarisation des revenus, et ce dans une perspective comparative entre pays. La distinction entre le concept de polarisation de celui d’inegalite et la comparaison de leur evolution au cours du temps portent un eclairage nouveau, y compris en matiere de politique economique, quant a la nature des changements de distribution du revenu.
The Effect Of Social Capital And Organizational Commitment Toward Lecturer Performance With Islamic Work Ethics As A Moderating Role

The number of private Islamic higher educations (PTIS) in Indonesia today amounted to 631 institutions. This condition has a tremendous potential in order to build the civilization of the Indonesian nation as aspired by Islam which is to be a nation that baldatun thoyyibatun wa rabbun ghaffur , a nation with a peace, the savety, and prosperity. The purpose of this study is to examine the impact of Islamic work ethic as moderating role on the influence of social capital and organizational commitment to the performance of lecturers. Researcher is using random sampling technique. The data collected from 236 respondents in PTIS that classified as “A” accredited by BANPT. Researcher analyzes the data collected by using WarlpPls 5.0. This research concluded that the social capital and organizational commitment has a positive effect on lecturer’s performance, Islamic work ethics reinforces these influences. However, the decision of researcher in choosing only “A” accredited as his research object make this study can’t be generalize.
Challenging the Disk Instability Model. I. The Case of YZ LMi

Observations of YZ LMi show enhanced emission along the stream trajectory beyond impact at the disk rim during outbursts as well as when the quiescent disk is large. We investigated whether these features can be explained in terms of either gas stream overflow or penetration within the frameworks of the disk instability model (DIM) and the mass-transfer instability model (MTIM) of outbursting disks. Gas stream overflow is not possible because the vertical scale height of the stream is significantly lower than that of the outer disk and because there is no combination of parameters which enables stream overflow on a larger disk while preventing it on a smaller disk. Stream penetration requires the gas stream to be denser than the outer disk regions. This requirement cannot be met by a low-viscosity DIM disk because its density is significantly larger than that of the gas stream over the whole range of mass-transfer rates where the thermal-viscous instability occurs. On the other hand, the high-viscosity MTIM disk has much lower densities which decrease with increasing radius, easily allowing for gas stream penetration during outbursts (when mass-transfer rate and stream density increase) as well as in large quiescent disks. The observed features are not consistent with DIM, but can be plausibly explained by MTIM. These results suggest that the outbursts of YZ LMi are the response of a high-viscosity disk to bursts of enhanced mass-transfer rate. In this case, the outburst decline timescale of (2–3) days implies a viscosity parameter in the range α = 3–4.
Perceived Competence: A Common Core for Self-Efficacy and Self-Concept?

This study uses Bandura's Multidimensional Scales of Perceived Self-Efficacy (MSPSE; Bandura, 1990) and Harter's Self-Perception Profile for Adolescents (SPPA; Harter, 1988) to examine the extent to which self-efficacy and competency-related elements of the self-concept are independent constructs. Factor analysis of data provided by 778 high school students revealed that when measured using domain-general measures such as the MSPSE and SPPA, self-efficacy and competency self-concept do not represent totally separate, distinct constructs. Overlap of dimensions occurs at both the first- and second-order levels of analysis. The practical and theoretical implications of these findings are discussed.