Miracle-dz/UniFAR-FTUs huggingface dataset:
GÖLGELEMENİN CAMAROSA ÇİLEK ÇEŞİDİNDE BÜYÜMEYE ETKİSİNİN KANTİTATİF ANALİZLERLE İNCELENMESİ

Bu calismada 3 farkli uygulamanin (plastik serada golgesiz, plastik serada surekli golgeleme ve acikta yetistiricilik) Camarosa cilek cesidinde buyume uzerine etkisi kantitatif analizlerle incelenmistir. Genel olarak toplam bitki, yaprak, govde ve kok kuru agirliklari acikta ve surekli golge uygulamasinda daha dusuk olmustur. Oransal yaprak agirligi genel olarak acikta en dusuk olurken 20 Mayis’tan itibaren daha yuksek olmustur. Oransal govde ve kok agirligi sonbahar-kis doneminde genel olarak yuksek olup acikta yetisen bitkilerde en fazla olmustur. Verim doneminde oransal govde ve kok agirligi genel olarak azalmis, bu azalma aciktaki bitkilerde daha belirgin olmustur. Ozgul yaprak alani genel olarak acikta dusuk ve 20 Mayis’tan itibaren surekli golgede daha yuksek olmustur. Yaprak kalinligi genellikle acikta yetisen bitkilerde en fazla, diger uygulamalar arasinda belirgin farklilik olmamakla birlikte surekli golgede biraz daha az olmustur. Oransal yaprak alani genellikle acikta dusuk, 20 Mayis’tan itibaren surekli golgede yuksek olmustur
Eye Fixation and Attention as Modifiers of Perceived Distance

An error in the perceived distance of a physically stationary object results in an apparent horizontal motion of the object if the head is moved horizontally. Procedures have been developed to use this apparent motion to measure the apparent distance of the object. Research also has indicated that the apparent distance of an object will tend to be displaced toward the distance at which the eyes are fixated. In the present study head-motion procedures were used to measure the effect of eye fixation and attention upon the apparent distance of a point of light in two experiments. Substantial errors in perceived distance occurred in the predicted direction as a function of fixation distance. Attending to an object at a distance other than the distance of the fixated point of light had a much less effect upon the apparent distance of the point. It is concluded that the apparent concomitant motion which occurs in a variety of situations as a function of the distance of fixation indicates that substantial errors in perceived distance are common in most environments.
The temperature of turbulent flows

We show that the random character of turbulent flows allows to define a quantity conserved along the length scales which we call the temperature. The corresponding “canonical" distribution of velocity differences at a given scale is derived on very general grounds. It is compared to the one derived by Dubrulle [1] and She and Waymire [2] from the hypothesis of She and Leveque [3]. Some consequences are drawn and this temperature is shown to be a rather easily measurable quantity.
Quality of life in patients with hypopituitarism

Purpose of reviewQuality of life (QoL) is impaired in patients with adults with growth hormone deficiency (AGHD) of any cause, especially if additional hypopituitarism is present, and improves after replacement therapy with recombinant human growth hormone (rhGH). This review includes relevant publications since 2013. Recent findingsRecent findings confirm that most patients with AGHD who improve their QoL after rhGH therapy experience persistent effects for years, if replacement therapy is maintained. Sometimes, however, QoL may not normalize completely, especially if it is caused by a craniopharyngioma (because of concomitant neuropsychological comorbidities that affect autonomy and cognitive function), or functional pituitary tumours, i.e., in Cushing's disease, in which chronic brain exposure to hypercortisolism is associated with more depression, anxiety, loss of memory and emotional distress. Another group in which QoL and energy rarely normalize despite improving after rhGH is hypopituitarism because of traumatic brain injury. Worse QoL is seen in patients who also suffer insomnia, depression, negative illness perceptions and are treated in a rural (compared with an urban) healthcare environment. Better QoL after rhGH is seen in AGHD patients who are not depressed, after successful surgery, living in Europe (rather than the USA), with poorer baseline QoL scores, less obesity and no impaired vision. SummaryFurther improvement of QoL may be possible with individualized psychosocial interventions.
Competitive Impacts of Software Patents in the IT Industry

While prior research has examined the role of Information Technology (IT) investments in the process and performance of innovation, there is relatively little research on the business value of IT innovation itself. In particular, the impact of a firm's IT innovation on the performance of the firm's rivals remains unexplored. In order to advance our understanding of the competitive impact of IT innovation, we investigate the impact of a firm's software patents on rivals' market value using data from the US IT industries. We find that a focal firm's software patent stock is negatively associated with its rivals' market value. In addition, we find interesting moderating effects of two factors: hardware patent stock and competitive intensity. Our results indicate that the focal firm's hardware patent stock amplifies the negative impact of its software patent stock on rivals' market value. Furthermore, we find that the competitive intensity of the industry mitigates the competitive impact of software patent stock. We discuss the implications for research and practice.
Treatment of post-burns bacterial infections by bacteriophages, specifically ubiquitous Pseudomonas spp. notoriously resistant to antibiotics.

Post-burn microbial infections are a major problem in recovering from the trauma of third-degree burns, and the survival of patients can depend upon the severity of the burn and the infections encountered. Within 24 hours, patients can start suffering from opportunistic bacterial attacks, which can vary from simple infection, such as those easily treatable by antibiotics, to more complicated types, which may have natural or acquired resistance to drugs. Infection by multiple drug-resistant bacteria can create additional complexity to the problem. As an alternative to treating bacterial infections by antibiotics, bacteriophages have been in use in certain parts of the world, such as at Tbilisi in Georgia and in Poland, and this approach has now been more widely recognized. Results have shown that phage therapy has an 80% success rate against Enterococcus infections and up to 90% against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. Here it is proposed that bacteriophages can effectively be used for the treatment of post-burn infections, particularly the ubiquitous opportunistic pathogens, Pseudomonas spp. , known to be notoriously resistant to a variety of antibiotics. This kind of treatment may be of particular importance in Third World countries where the incidence of burns and infections, due to lack of stringent safety regulations and proper hygiene respectively, may be more common and where cocktails of antibiotics may be less affordable. Phages that can possibly be employed in the treatment and their advantages compared to the use of antibiotics are also highlighted.
Intracerebral Hemorrhage: A Life‐Threatening Complication of Hypertension During Pregnancy

Intracerebral hemorrhage (ICH) is an infrequent but severe complication in pregnant women with hypertension. The authors describe a patient with chronic hypertension who developed superimposed preeclampsia and spontaneous ICH during the thirty‐fifth week of pregnancy. ICH was diagnosed by computed tomographic scan. She underwent successful emergent cesarean section and neurosurgical decompression of the ICH. Both intraoperative surveillance and postoperative magnetic resonance angiographic examination of the cerebral vessels failed to identify an aneurysm or arteriovenous malformation. The authors discuss the diagnosis and management in this case and review the literature regarding this challenging complication of pregnancy and preeclampsia. Controversies regarding treatment of hypertension during pregnancy are discussed in light of the impact on the management of this patient.
Styles of Thinking among Learning Disabled and Slow Learners

Thinking is a process of human mind. It is a main function of human behavior. Students with learning disabilities have average or above average intelligence with specific cognitive, thinking, or psychological processing problems. The chief deficiency in slow learners is in the area of intelligence. They lack in reasoning ability. The population for the present investigation defined as learning disabled, slow learners, and non disabled learners’ school students from Ernakulam district, Kerala. The study revealed that there is significant difference among the learning disabled, slow learners and normal learners in styles of thinking. This means that styles of thinking of three groups based on creative thinking, problem solving thinking, imaginary thinking is significantly different.
Validation of the Chinese version of the physical activity stages of change questionnaire

Abstract Background/Objective: Sharp decline in physical activity has been observed among Chinese youth in recent decades. The transtheoretical model of behavior change (TTM) provides a useful framework for developing effective intervention programs. Yet the application of the TTM in China has been limited due to the lack of a valid TTM-based questionnaire to examine different stages of physical activity behavior. Therefore, the purpose of the present study was to translate the Physical Activity Stages of Change Questionnaire (PASCQ), which is a well-validated scale based on the TTM, into Chinese and to test the psychometric properties of this Chinese version. Methods: The PASCQ was translated from English into Chinese and its internal consistency, one-week test–retest reliability and concurrent validity were tested in a sample of Chinese university students. Results: Both the internal consistency and the test–retest reliability satisfied psychometric standards. The Chinese version of the PASCQ also successfully discriminated between individuals with different levels of physical activity, which indicated a good concurrent validity. In particular, participants in the action and maintenance stages reported significantly higher energy expenditure than participants in the precontemplation, contemplation, and preparation stages. Conclusions: The results indicate good reliability and concurrent validity of the Chinese version of the PASCQ. The questionnaire may be profitably used to identify individuals at different stages of physical activity behavior, which may help in physical activity promotion programs among Chinese college students.
Short course acid suppressive treatment for patients with functional dyspepsia: results depend onHelicobacter pyloristatus

BACKGROUND AND AIMS Treatment of functional dyspepsia with acid inhibitors is controversial and it is not known if the presence ofHelicobacter pylori infection influences the response. METHODS After a complete diagnostic workup, 792 patients with functional dyspepsia unresponsive to one week of low dose antacid treatment were randomised to two weeks of treatment with placebo, ranitidine 150 mg, omeprazole 10 mg, or omeprazole 20 mg daily. Individual dyspeptic and other abdominal symptoms were evaluated before and after treatment according to H pylori status. RESULTS The proportions of patients considered to be in remission (intention to treat) at the end of treatment with placebo, ranitidine 150 mg, omeprazole 10 mg, and omeprazole 20 mg were, respectively, 42%, 50%, 48%, and 59% in the H pylori positive group and 66%, 73%, 64%, and 71% in the H pylori negative group. In H pyloripositive patients, the therapeutic gain over placebo was significant for omeprazole 20 mg (17.6%, 95% confidence intervals (CI) 4.2–31.0; p<0.014 using the Bonferroni-adjusted p level of 0.017) but not for omeprazole 10 mg (6.8%, 95% CI −6.7–20.4) or ranitidine 150 mg (8.9%, 95% CI −4.2–21.9). There was no significant therapeutic gain from active treatment over placebo in H pylori negative patients. Complete disappearance of symptoms and improvement in quality of life also occurred most frequently with omeprazole 20 mg and was significant in both H pylori positive and H pylori negative groups. The six month relapse rate of symptoms requiring treatment was low (<20%) in all groups. CONCLUSIONS Omeprazole 20 mg per day had a small but significant favourable effect on outcome in H pylori positive patients. The differential response in these patients may be explained by an enhanced antisecretory response in the presence of H pylori. The effect of weaker acid inhibition was unsatisfactory.
Phosphorylation of Distinct Sites in MeCP2 Modifies Cofactor Associations and the Dynamics of Transcriptional Regulation

ABSTRACT Mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) lead to disrupted neuronal function and can cause the neurodevelopmental disorder Rett syndrome. MeCP2 is a transcriptional regulator that binds to methylated DNA and is most abundant in neuronal nuclei. The mechanisms by which MeCP2 regulates gene expression remain ambiguous, as it has been reported to function as a transcriptional silencer or activator and to execute these activities through both gene-specific and genome-wide mechanisms. We hypothesized that posttranslational modifications of MeCP2 may be important for reconciling these apparently contradictory functions. Our results demonstrate that MeCP2 contains multiple posttranslational modifications, including phosphorylation, acetylation, and ubiquitylation. Phosphorylation of MeCP2 at S229 or S80 influenced selective in vivo interactions with the chromatin factors HP1 and SMC3 and the cofactors Sin3A and YB-1. pS229 MeCP2 was specifically enriched at the RET promoter, and phosphorylation of MeCP2 was necessary for differentiation-induced activation and repression of the MeCP2 target genes RET and EGR2. These results demonstrate that phosphorylation is one of several factors that are important for interpreting the complexities of MeCP2 transcriptional modulation.
Perioperative Statin Therapy Is Not Associated With Reduced Risk of Anastomotic Leakage After Colorectal Resection

BACKGROUND: Anastomotic leakage is a serious complication of colorectal surgery. Several studies have demonstrated the beneficial pleiotropic effects of statins, and preliminary studies have suggested that perioperative statin treatment may be associated with reduced risk of anastomotic leakage. OBJECTIVE: We aimed to investigate whether perioperative statin therapy was associated with a reduced anastomotic leakage rate after colorectal resections with primary anastomosis. DESIGN: The study was based on prospectively collected data from the Danish Colorectal Cancer Group and electronically registered medical records holding information on perioperative statin therapy. SETTINGS: Data were collected from the 6 major surgical centers responsible for all elective colorectal cancer surgery in the eastern part of Denmark. PATIENTS: We collected data on 2766 patients with electronically registered medical records who underwent resection of the colon or rectum with primary anastomosis from 2006 to 2009. MAIN OUTCOME MEASURE: The primary outcome measured was anastomotic leakage requiring surgical intervention. RESULTS: Five hundred eighteen patients (19%) were treated with statins perioperatively. Four hundred ninety-six patients received statins both before and after surgery. Fifty-two patients (10.5%) received high-dose statin therapy. Possible risk factors for anastomotic leakage were identified via univariate regression analyses. In subsequent multivariate analysis, perioperative statin therapy was not associated with reduced anastomotic leakage rate (OR (95% CI) 1.31 (0.84–2.05), p = 0.23). We identified intraoperative blood transfusion, rectal resection (versus colonic), male sex, and tobacco usage as risk factors for anastomotic leakage in the multivariate analysis. LIMITATIONS: This study is limited by its observational design and missing data on comorbidities and BMI. CONCLUSION: Perioperative statin therapy was not significantly associated with reduced anastomotic leakage rate after colorectal resection with primary anastomosis.
Behavior of Mesenchymal Stem Cells in the Chemical Microenvironment of the Intervertebral Disc

Study Design. Responses of mesenchymal stem cells (MSCs) from 2 age groups was analyzed under chemical conditions representative of the intervertebral disc (IVD) (low glucose levels, acidic pH, high osmolarity, and combined conditions). Objective. To determine the microenvironmental conditions of the IVD that are critical for MSC-based tissue repair and to determine whether MSCs from different age groups respond differently. Summary of Background Data. MSCs offer promise for IVD repair, but their potential is limited by the harsh chemical microenvironment in which they must survive. Methods. MSCs were isolated from bone marrow from mature (4–5 month old) and young (1 month old) rats and cultured in monolayer under IVD-like glucose, osmolarity, and pH conditions as well as under a combination of these conditions and under standard media conditions for 2 weeks. The response of MSCs was examined by measuring gene expression (real-time RT-PCR), proliferation (MTT assay), and viability (fluorescence staining). Results. Culturing under IVD-like glucose conditions (1.0 mg/mL glucose) stimulated aggrecan and collagen-1 expression and caused a small increase in proliferation. In contrast, IVD-like osmolarity (485 mOsm) and pH (pH = 6.8) conditions strongly decreased proliferation and expression of matrix proteins, with more pronounced effects for osmolarity. Combining these 3 conditions also resulted in decreased proliferation, and gene expression of matrix proteins, demonstrating that osmolarity and pH dominated the effects of glucose. Both age groups showed a similar response pattern to the disc microenvironment. Conclusion. IVD repair using MSCs requires increased knowledge of MSC response to the chemical microenvironment. IVD-like low glucose enhanced matrix biosynthesis and maintained cell proliferation whereas IVD-like high osmolarity and low pH conditions were critical factors that reduced biosynthesis and proliferation of young and mature MSCs. Since osmolarity decreases and acidity increases during degeneration, we speculate that pH may be the major limitation for MSC-based IVD repair.
In Vitro Activity of Sch 21420, Derivative of Gentamicin B, Compared to That of Amikacin

The minimal inhibitory concentration of Sch-21420 closely paralleled amikacin for 125 strains of aerobic gram-negative bacilli and Staphylococcus aureus primarily selected for testing because of resistance to other aminoglycoside antibiotics. Fifteen of 26 strains requiring 20 μg or more of amikacin per ml for inhibition were inhibited by two- to fourfold less Sch 21420. The majority of organisms resistant to both agents owed their resistance to mechanisms other than the carriage of aminoglycoside-modifying enzymes. Most strains carrying aminoglycoside 6′-acetyltransferase, capable of modifying amikacin, were susceptible to 10 μg or less of Sch 21420 per ml.
English in Contact with Pennsylvania German.

The Pennsylvania Germans (also commonly known as the Pennsylvania Dutch) provide an interesting paradigm of the nature of language contact because within the total Pennsylvania German community is enmeshed a variety of subgroups, each having a different relation to the dominant culture. The Pennsylvania German community is not one community, culturally or linguistically, and this diversity is reflected in the nature and extent of the languages used by the various communities which comprise the whole Pennsylvania German group. The Pennsylvania Germans began arriving in America as early as 1683. The German dialect they brought with them resembles most closely the Franconian dialects of the Rhenish Palatinate with some Alemanic influences. ' This dialect continues to be spoken natively by many Pennsylvania Germans today, especially by the Old Order Amish and Old Order Mennonites, who form a small but highly visible percentage of the total Pennsylvania German population. Members of the Old Order sects (the plain people) generally learn English in school and use it in school and when speaking to outsiders. Old Order religious rites and ceremonies are conducted in a form of High German which is essentially the eighteenthcentury literary German of their Bible and hymnal. No one converses in this High German form, and most Old Order people have only a passive knowledge of it. It is recited with Pennsylvania German phonology. Pennsylvania German is the main language used within plain families and communities, the language which is passed on to children as their mother tongue. Less conservative Amish and Mennonites tend to use more English in their daily lives and religious services than do the Old Orders, and this parallels their greater accommodation of the dominant culture in terms of life style.
Central pulse pressure predicts BP reduction after renal denervation in patients with treatment-resistant hypertension.

AIMS Enhanced vascular ageing is associated with elevated central pulse pressure (cPP), an independent predictor of cardiovascular (CV) events. Although antihypertensive treatment strategies are effective, high residual CV risk remains indicative of advanced and largely irreversible vascular damage. Renal denervation (RDN) has been shown to reduce blood pressure (BP) to various extents in patients with treatment-resistant hypertension (TRH). We hypothesised that cPP predicts BP reduction after RDN. METHODS AND RESULTS Sixty-three patients with true TRH underwent catheter-based RDN using the Symplicity Flex™ catheter and were followed for six months. At baseline, cPP was assessed by pulse wave analysis (SphygmoCor™). Patients were stratified according to their median cPP (55 mmHg), and called "low cPP" (below the median) or "high cPP" (above the median). Office BP reduction six months after RDN was greater (-22±19/-13±11 vs. -12±20/-5±13 mmHg, p=0.038/0.014) and 24-hr ambulatory blood pressure (ABP) reduction tended to be greater (-11±13/-8±10 vs. -3±18/-4±10 mmHg, p=0.070/0.112) in patients with low cPP compared to those with high cPP. Only cPP (β=0.687, p=0.001) and baseline systolic BP (β=-0.564, p<0.001) were independent determinants of office systolic BP reduction after RDN. CONCLUSIONS Our data suggest that cPP, indicative of the degree of large arterial stiffening, may be helpful to identify responders to RDN.