Miracle-dz/UniFAR-FTUs huggingface dataset:
Substrate Effects on In-Plane Magnetic Anisotropy and Verwey Transition Temperatures of (100) Magnetite (Fe3O4) Films

(100) Fe<sub>3</sub>O<sub>4</sub> films were grown on five different (100)-oriented substrates: MgO, MgAl<sub>2</sub>O<sub>4</sub> (MAO), (PbMg<sub>0.33</sub>Nb<sub>0.67</sub>)<sub>1-x</sub>:(PbTiO<sub>3</sub>)<sub>x</sub> (PMNT), SrTiO<sub>3</sub> (STO), and (LaAlO<sub>3</sub>)<sub>0.3</sub>(Sr<sub>2</sub>AlTaO<sub>6</sub>)<sub>0.7</sub> (LSAT), to investigate the substrate effects on structural, magnetic, and transport properties of the films. The X-ray diffraction measurements suggested that the epitaxial (100) Fe<sub>3</sub>O<sub>4</sub> films were grown, although the lattice mismatch between the Fe<sub>3</sub>O<sub>4</sub> and the substrates varied from +0.25% to -7.8%. Remarkably, the (100) Fe<sub>3</sub>O<sub>4</sub> films grown on MAO, PMNT, and STO substrates exhibited a distinctive in-plane magnetic anisotropy with the magnetic easy axis along the [010] and [001] directions. In contrast, the (100) Fe3O4 films on the MgO and LSAT substrates showed a very weak anisotropy in the [011] easy direction. The Verwey transition temperature of the (100) Fe<sub>3</sub>O<sub>4</sub> film was found to have a minimum value of ~110 K for MgO and a maximum value of ~122 K for STO. These results suggest that the magnetic anisotropy and Verwey transition behaviors of the (100) Fe<sub>3</sub>O<sub>4</sub> film can be tuned by film growth on a specific substrate.
The frequent Marburg I polymorphism impairs the pro-urokinase activating potency of the factor VII activating protease (FSAP)

The recently reported plasmatic, Factor Seven Activating Protease (FSAP), has also been found to be a potent activator of pro-urokinase [single-chain plasminogen activator, urinary type (scuPA)]. An initial epidemiological study surprisingly showed that plasmas of 5–10% of healthy blood donors had an impaired potential to activate scuPA. Analysis of the respective genomic DNAs revealed one particular single nucleotide polymorphism of FSAP resulting in an identical amino acid exchange (G511E), which correlates with the reduced activities. The corresponding mutation was named FSAP Marburg I. Thrombelastographies of wild-type and mutant plasmas were performed, facilitating the auto-activation of the intrinsic FSAP pro-enzymes by addition of dextran sulfate (DXS) and accelerated clot lysis by addition of scuPA. On these conditions, tissue-factor-induced coagulation revealed that clot lysis was significantly delayed in the Marburg I mutant plasmas as compared with wild-type plasmas. Furthermore, in the presence of DXS and scuPA, a FSAP-deficient plasma revealed significantly prolonged plasma clot lysis times, whereas the addition of purified FSAP pro-enzyme plus scuPA reversed this effect. These results support the hypothesis that FSAP contributes to the scuPA-dependent plasma fibrinolytic potential, which can be impaired in plasmas containing the FSAP Marburg I polymorphism, for instance.
Clinical Evaluation of Bovine Derived Xenograft with a Bioabsorbable Collagen Membrane in the Treatment of Molar Class II Furcation Defects

The aim of this study is to clinical evaluation bovine derived xenograft with guided tissue regeneration membrane used was osseoguardresorbable collagen membrane in the treatment of human periodontal Class II molar furcation defects. Ten patients(6 males, 4 females) suffering from chronic periodontitis, with Grade II molar furcation defect, were treated using bovine derived xenograft with GTR membrane, completed the study with the following clinical parameters were assessed immediately before the surgical procedure(Baseline) and at 6 months after treatment. These parameters were, Plaque index Score(PlI),gingival index (GI) vertical probing depth (VPD) ,clinical attachment level (CAL),gingival recession(GR) and closed horizontal probing depth (CHPD). This therapy resulted in significant VPD reductions and no significant improvement was seen (CAL),(GR) and significant reduction of(CHPD). For the mean values for the of (VPD)(5.3 ± 1.35),(CAL)( 3.5±1.4), (GR)( 0.3±0.51) and(CHPD)( 4.8±0.99) at baseline ,while these parameters at 6 months after surgical treatment were(2.82 ± 1.56),(2.3± 1.4), (0.28±0.5)and(2.2±1.54) respectively. The findings of this study suggest improvement in clinical results when the use of resorbable collagen membrane with bovine derived xenograft in treatment of class II molar furcation involvement.
Combined Botulinum Toxin Type A With Modified Constraint-Induced Movement Therapy for Chronic Stroke Patients With Upper Extremity Spasticity: A Randomized Controlled Study

Background and objective . Botulinum toxin type A (BtxA) injection and modified constraint-induced movement therapy (mCIMT) are both promising approaches to enhance recovery after stroke. The combined application of these 2 promising modalities has rarely been studied. The aim was to investigate whether combined BtxA and mCIMT would improve spasticity and upper extremity motor function more than BtxA plus conventional rehabilitation in chronic stroke patients with upper extremity spasticity. Methods. In a prospective, randomized controlled, observer-blinded trial with 6-month follow-up, 32 patients (≥1 year after stroke) with ability to actively extend >10° at metacarpophalangeal and interphalangeal joints and 20° at wrist of the affected upper limb were randomized to receive BtxA + mCIMT (combination group) or BtxA + conventional rehabilitation (control group) for 2 hours/day, 3 days/week for 3 months.The primary outcome assessed spasticity on the Modified Ashworth Scale. Secondary outcomes assessed real-world arm function (Motor Activity Log), laboratory motor activity (Action Research Arm Test), and patients’ global satisfaction. Results. A total of 32 stroke patients were recruited, and 29 completed the study. Spasticity significantly improved in all subjects at 4 weeks and 3 months postinjection without between-group differences.The combination group showed significantly greater improvements in elbow, wrist, and finger spasticity (P = .019, P = .019, and P < .001, respectively), affected upper extremity real-world arm function (P < .001) and laboratory motor activity (P < .001) than the control group at 6-month postinjection. Patients reported considerable satisfaction and no serious adverse events occurred. Conclusions. Combining BtxA and mCIMT is an effective and safe intervention for improving spasticity and motor function in chronic stroke patients. The results are promising enough to justify further studies. We recommend future research to address the likely need for including rehabilitation with BtxA to improve function in patients with poststroke spasticity.
Physical activity and physique anxiety in older adults: Fitness, and efficacy influences

Employing a randomized controlled trial, this study documents the effects of six months of physical activity and six month follow-up on reduction in social physique anxiety (SPA) in older adults. In addition, the role played by changes in behavioral, physiological, and psychological predictors of changes in SPA were examined. Participants ( n = 174, mean age = 65 yrs) were randomly assigned to one of two activity groups and engaged in a six-month structured exercise program. Measures of physique anxiety were taken at baseline, six and twelve months. Latent growth curve analyses revealed significant reductions in SPA over the course of the 12-month period. Structural analyses controlling for treatment condition indicated that improvements in self-efficacy and fitness were significant predictors of changes in SPA but that changes in body fat and exercise frequency did not contribute to variation in SPA. Overall this model accounted for 19% of the variation in SPA changes. The extent to which changes in SPA may contribute to continued physical activity participation in older adults and how exercise programs might effectively influence predictors of SPA are discussed.
Correlation between cell killing and massive second-round superinfection by members of some subgroups of avian leukosis virus

Avian leukosis viruses of subgroups B, D, and F are cytopathic for chicken cells, whereas viruses of subgroups A, C, and E are not. The amounts of unintegrated linear viral DNA in cells at different times after infection with cytopathic or noncytopathic viruses were determined by hybridization and transfection assays. Shortly after infection, there is a transient accumulation of unintegrated linear viral DNA in cells infected with cytopathic avian leukosis viruses. By 10 days after infection, the majority of this unintegrated viral DNA is not present in the infected cells. The transient cytopathic effect seen in these infected cells also disappears by this time. Low amounts of unintegrated linear viral DNA persist in these cells. Cells infected with noncytopathic viruses do not show this transient accumulation of unintegrated viral DNA. Cells infected with cytopathic viruses and subsequently grown in the presence of neutralizing antibody do not show the transient accumulation of unintegrated viral DNA or cytopathic effects. These results demonstrate a correlation between envelope subgroup, transient accumulation of unintegrated linear viral DNA, and transient cell killing by avian leukosis viruses. The cell killing appears to be the result of massive second-round superinfection by the cytopathic avian leukosis viruses.
Strategic planning for instream flow restoration: a case study of potential climate change impacts in the central Columbia River basin

We provide a case study prioritizing instream flow restoration activities by sub‐basin according to the habitat needs of Endangered Species Act (ESA)‐listed salmonids relative to climate change in the central Columbia River basin in Washington State (USA). The objective is to employ scenario analysis to inform and improve existing instream flow restoration projects. We assess the sensitivity of late summer (July, August, and September) flows to the following scenario simulations – singly or in combination: climate change, changes in the quantity of water used for irrigation and possible changes to existing water resource policy. Flows for four sub‐basins were modeled using the Water Evaluation and Planning system (WEAP) under historical and projected conditions of 2020 and 2040 for each scenario. Results indicate that Yakima will be the most flow‐limited sub‐basin with average reductions in streamflow of 41% under climate conditions of 2020 and 56% under 2040 conditions; 1.3–2.5 times greater than those of other sub‐basins. In addition, irrigation plays a key role in the hydrology of the Yakima sub‐basin – with flow reductions ranging from 78% to 90% under severe to extreme (i.e., 20–40%) increases in agricultural water use (2.0–4.4 times the reductions in the other sub‐basins). The Yakima and Okanogan sub‐basins are the most responsive to simulations of flow‐bolstering policy change (providing salmon with first priority water allocation and at biologically relevant flows), as demonstrated by 91–100% target flows attained. The Wenatchee and Methow sub‐basins do not exhibit similar responsiveness to simulated policy changes. Considering climate change only, we conclude that flow restoration should be prioritized first in the Yakima and Wenatchee sub‐basins, and second in the Okanogan and Methow. Considering both climate change and possible policy changes, we recommend that the Yakima sub‐basin receive the highest priority for flow restoration activities to sustain critical instream habitat for ESA‐listed salmonids.
Decreased serum TSH levels are not associated with mortality in the adult northeast German population.

OBJECTIVE Results of cohort studies on the association between decreased serum TSH levels and mortality are conflicting. Some studies demonstrated an increased mortality risk in subjects with decreased serum TSH levels, others did not. Even meta-analyses revealed contradictory results. We undertook the present study to investigate the association between decreased serum TSH levels and mortality in the large population-based Study of Health in Pomerania (SHIP). DESIGN AND METHODS Data from 3651 individuals from SHIP without known thyroid disorders or thyroid treatment were analyzed. Serum TSH, free triiodothyronine, and free thyroxine levels were determined by immunochemiluminescent procedures. Decreased TSH was defined as serum TSH levels below 0.25 mIU/l. Cox regression was used to associate decreased TSH levels with mortality. RESULTS The median duration of follow-up was 8.5 years (30 126 person years). During follow-up, 299 individuals (6.9%) died corresponding to a death rate of 9.92 deaths per 1000 person years. Survival time was shorter in subjects with decreased serum TSH levels compared to euthyroid individuals. After adjustment for age and sex, however, there was no association between decreased serum TSH levels and all-cause mortality (hazard ratio: 0.95; 95% confidence interval: 0.67; 1.36). Likewise, decreased serum TSH levels were neither associated with cardiovascular nor with cancer mortality. CONCLUSIONS There is no independent association of decreased serum TSH levels with all-cause, cardiovascular, and cancer mortality in the adult northeast German population. Although our study has some strengths, we cannot finally conclude on therapeutical implications in individuals with subclinical thyroid diseases.
Failure to detect an association between aggressive periodontitis and the prevalence of herpesviruses.

BACKGROUND Herpes simplex virus type 1 (HSV-1), human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) have been suspected to play a causal role in periodontitis pathogenesis. The aim of this study was to determine the prevalence of these viruses in subgingival plaque samples of Caucasian patients with generalized aggressive periodontitis compared to periodontally healthy controls. METHODS A total of 65 patients with aggressive periodontitis and 65 unmatched controls from Germany were investigated in the study. Subgingival plaque samples were analysed for the presence of HSV-1, EBV and HCMV by quantitative real-time polymerase chain reaction assays. Viral antibody titres were determined quantitatively by immunosorbent assays. RESULTS DNA of HSV-1 and HCMV were detected in 1.5% of the patients and controls, whereas EBV DNA was present in 10.8% and 13.9% respectively. Detection rates of serum IgG against HSV-1 (76.1% versus 73.9%), EBV (98.5% versus 96.9%), HCMV (47.7% versus 46.2%) and IgM levels against HSV-1 (6.2% versus 1.5%), EBV (0% versus 0%), HCMV (0% versus 1.5%) did not significantly differ between patients and controls. CONCLUSION The data of our study do not suggest any contribution of HSV-1, EBV or HCMV to aggressive periodontitis in a German population. Ethnic and methodological aspects might have caused conflicting results of previous studies.
Heart failure after myocardial infarction: prevalence of preserved left ventricular systolic function in the community.

BACKGROUND Studies have reported that a large proportion of the cases of congestive heart failure (CHF) with mixed etiologies have preserved left ventricular systolic function. Whether this is the case in subjects with CHF after myocardial infarction (MI) is not known. This study was undertaken to examine the prevalence and characteristics associated with CHF in patients who had preserved ejection fraction (LVEF) after MI. METHODS Clinical characteristics and LVEF were ascertained in a population-based cohort of patients with CHF after incident MI in Olmsted County, Minn. All MIs were validated by use of standardized epidemiological criteria, and all episodes of CHF were validated by use of Framingham criteria. RESULTS Between 1979 and 1994, 1658 patients had an MI, and 644 of these patients (38%) had CHF during 7.4 +/- 5.4 years of follow-up. Of these patients, 395 (61%) underwent LVEF assessment. Preserved LVEF (ie, > or =50%) was present in 30% of cases, and this proportion did not change with time. The proportion of women with CHF and preserved LVEF (37%) was greater than the proportion of men (23%, P =.002). The positive association between female sex and preserved LVEF remained significant after adjustment (odds ratio 1.97, 95% CI 1.26-3.07, P =.003). The highest tertile of peak creatinine phosphokinase level was negatively associated with preserved LVEF (odds ratio 0.51, 95% CI 0.29-0.89). CONCLUSION A notable proportion of cases of CHF after MI have preserved LVEF. This underscores the burden of CHF with preserved LVEF in a well-defined group of patients with documented coronary disease. CHF with preserved LVEF after MI is associated with female sex and smaller MI size.
SUCCESSIVE WAVES OF APOPTOSIS IN THE RAT PROSTATE AFTER REPEATED WITHDRAWAL OF TESTOSTERONE STIMULATION

&NA; In rats with castration‐induced ventral prostatic atrophy, testosterone treatment resulted in reconstitution of the normal weight and histological structure of the gland within 10 d. Subsequent withdrawal of the hormone was followed by rapid involution, which was effected by a combination of extensive loss of epithelial cells by apoptosis and decrease in the size of the cells that remained. The wave of apoptotic deletion was similar to that accompanying the initial involution after castration, and in both cases the rate of apoptosis fell to very low levels by 20 d. Two further consecutive episodes of involution produced by sequential administration and withdrawal of testosterone were also accompanied by similar waves of apoptosis. The results provide quantitative evidence supporting suggestions that apoptosis may be of major kinetic significance in the involution of endocrine‐dependent glandular tissues. The majority of the epithelial cells remaining after the completion of involution were able to survive continuing androgen deprivation, but with renewed testosterone stimulation they repeatedly generated populations that once again responded to withdrawal with massive cellular death. The factors determining the selective susceptibility of individual cells in these populations clearly merit investigation.
Effect of heptabarbital on the response to bishydroxycoumarin in man.

Abstract The effect of pretreatment with heptabarbital on the response to orally and intravenously administered bishydroxycoumarin was studied in man. After pretreatment with heptabarbital, the mean reduction in the prothrombin level, the amount of bishydroxycoumarin in plasma, and the half-life of bishydroxycoumarin were significantly less than in control experiments whether bishydroxycoumarin was given orally or intravenously. However, the effect of heptabarbital was greater when bishydroxycoumarin was given orally than intravenously. Unchanged bishydroxycoumarin was found in the stool when it was given orally in control experiments, but it was present in much larger quantities after pretreatment with heptabarbital. No unchanged bishydroxycoumarin was found in the stool after its intravenous administration whether or not heptabarbital was given. However, an increased amount of bishydroxycoumarin metabolite was present after pretreatment with heptabarbital. Presumably, at least part of the response to heptabarbital was caused by increased metabolism of bishydroxycoumarin due to enzyme induction in the liver. The more pronounced effect of heptabarbital on the orally administered drug was apparently caused by the added feature of decreased absorption of bishydroxycoumarin from the gastrointestinal tract.
SiGe Bipolar VCO With Ultra-Wide Tuning Range at 80 GHz Center Frequency

A SiGe millimeter-wave VCO with a center frequency around 80 GHz and an extremely wide (continuous) tuning range of 24.5 GHz ( ap 30%) is presented. The phase noise at 1 MHz offset is -97 dBc/Hz at the center frequency (and less than -94 dBc/Hz in a frequency range of 21 GHz). The maximum total output power is about 12 dBm. A cascode buffer improves decoupling from the output load at reasonable VCO power consumption (240 mW at 5 V supply voltage). A low-power frequency divider (operating up to 100 GHz) provides, in addition, a divided-by-four signal. As a further intention of this paper, the basic reasons for the limitation of the tuning range in millimeter-wave VCOs are shown and the improvement by using two (instead of one) varactor pairs is demonstrated.
Functional electrical stimulation on chronic and acute hemiplegic shoulder subluxation.

OBJECTIVE The present study investigated and assessed the effectiveness of a functional electrical stimulation (FES) program in the management of acute and chronic shoulder subluxation. DESIGN By their postonset duration, hemiplegic subjects with subluxation participating in the study were placed into a short-duration group and a long-duration group. Subjects in each group were further assigned randomly to either a control subgroup or an experimental subgroup. The experimental subgroups of both short and long duration received FES therapy in which supraspinatus and posterior deltoid were induced to contract repetitively up to 6 hr/day for 6 wk. The duration of the FES session and muscle contraction/relaxation ratio were progressively increased as performance improved. RESULTS The experimental subgroup of short duration showed significant improvements in reducing subluxation as indicated by x-ray compared with the control subgroup of short duration after the first FES treatment. The same effect was not shown for the experimental subgroup of long duration. The second FES treatment program only resulted in an insignificant change of shoulder subluxation for both the short- and long-duration subgroups. CONCLUSIONS The present study suggests that hemiplegic subjects with short postonset duration are effectively trained for shoulder subluxation by the first FES treatment program. The same FES showed not to be effective when applied to the subjects with subluxation of > 1 yr.
Non-HLA gene polymorphisms in juvenile idiopathic arthritis: associations with disease outcome

Objective: To test the hypothesis that non-HLA single-nucleotide polymorphisms (SNPs) associated with the risk of juvenile idiopathic arthritis (JIA) are risk factors for an unfavourable disease outcome at long-term follow-up. Methods: The Nordic JIA cohort is a prospective multicentre study cohort of patients from the Nordic countries. In all, 193 patients met the inclusion criteria of having an 8 year follow-up assessment and available DNA sample. Seventeen SNPs met the inclusion criteria of having significant associations with JIA in at least two previous independent study cohorts. Clinical endpoints were disease remission, actively inflamed joints and joints with limitation of motion (LOM), articular or extra-articular damage, and history of uveitis. Results: Evidence of associations between genotypes and endpoints were found for STAT4, ADAD1-IL2-IL21, PTPN2, and VTCN1 (p = 0.003–0.05). STAT4_rs7574865 TT was associated with the presence of actively inflamed joints [odds ratio (OR) 20.6, 95% confidence interval (CI) 2.2–> 100, p = 0.003] and extra-articular damage (OR 7.9, 95% CI 1–56.6, p = 0.057). ADAD1_rs17388568 AA was associated with a lower risk of having joints with LOM (OR 0.1, 95% CI 0–0.55, p = 0.016). PTPN2_rs1893217 CC was associated with a lower risk of having joints with LOM (OR 0.2, 95% CI 0–0.99, p = 0.026), while VTCN1_rs2358820 GA was associated with uveitis (OR 3.5, 95% CI 1–12.1, p = 0.029). Conclusion: This exploratory study, using a prospectively followed JIA cohort, found significant associations between long-term outcome and SNPs, all previously associated with development of JIA and involved in immune regulation and signal transduction in immune cells.