Miracle-dz/UniFAR-FTUs huggingface dataset:
A Pilot Study of the Use of Guided Imagery for the Treatment of Recurrent Abdominal Pain in Children

Few effective therapies are available for children with recurrent abdominal pain (RAP). Relaxation and guided imagery have been shown to impact the autonomic nervous system, which is altered in patients with functional gastrointestinal disorders. Ten children with RAP were enrolled in the study after evaluation by a pediatric gastroenterologist. They were trained in relaxation and guided imagery during 4 weekly 50-minute sessions. Pain diaries were completed at 0, 1, and 2 months. Children and parents also completed psychological questionnaires at enrollment. Although refractory to conventional treatment by their physician and pediatric gastroenterologist, the children experienced a 67% decrease in pain during the therapy (chi-square for trend, p<0.001). No baseline psychological characteristics impacted the response to therapy. The use of relaxation along with guided imagery is an effective and safe treatment for childhood RAP.
Do We Need Three-Dimensional Computed Tomography in Maxillofacial Surgery?

In a retrospective clinical study (2000–2003), 121 patients’ radiographs and computed tomography scans were reviewed to establish the clinical value of three-dimensional computed tomography. Eighty patients had computed tomography scans; 48 had three-dimensional computed tomography scans for diagnosing facial fractures, 3 for diagnosing temporomandibular joint ankylosis, 1 for tumor with bone destruction, and 1 for a mandibular cyst. It is concluded that axial, coronal, and three-dimensional computed tomography is of crucial importance and should be mandatory for all suspected comminuted and displaced midface fractures instead of plain radiographs. Three-dimensional computed tomography is also recommended for comminuted mandibular fractures and temporomandibular joint ankylosis. Three-dimensional computed tomography is not recommended for the diagnosis of minimally displaced fractures.
Zero-Inflated Poisson Modeling of Fall Risk Factors in Community-Dwelling Older Adults

The aim of this study was to identify risk factors for falls among community-dwelling older adults. The study used a cross-sectional descriptive design. Self-report questionnaires were used to collect data from 658 community-dwelling older adults and were analyzed using logistic and zero-inflated Poisson (ZIP) regression. Perceived health status was a significant factor in the count model, and fall efficacy emerged as a significant predictor in the logistic models. The findings suggest that fall efficacy is important for predicting not only faller and nonfaller status but also fall counts in older adults who may or may not have experienced a previous fall. The fall predictors identified in this study—perceived health status and fall efficacy—indicate the need for fall-prevention programs tailored to address both the physical and psychological issues unique to older adults.
Correlates of posttraumatic growth in husbands of breast cancer survivors

Following breast cancer, many survivors and spouses report posttraumatic growth (PTG)—positive life changes. This correlational study identified social context and event‐related correlates of PTG among husbands of breast cancer survivors (N=72). Bivariate analyses indicated that husbands' PTG was positively associated with general social support, greater marital support and depth of commitment, greater PTG in wife, shorter time since diagnosis and breast cancer meeting DSM‐IV criteria for traumatic stressor. Multiple regression analysis revealed that the significant predictors of husbands' PTG were depth of marital commitment, wife's PTG, and breast cancer meeting DSM‐IV traumatic stressor criteria. Psychosocial research and interventions need to acknowledge that couples face the cancer together and share not only the pain but also the potential for gain from the trauma. Copyright © 2003 John Wiley & Sons, Ltd.
Trends in End‐of‐Life Care in Pediatric Hematology, Oncology, and Stem Cell Transplant Patients

Decisions about end‐of‐life care may be influenced by cultural and disease‐specific features. We evaluated associations of demographic variables (race, ethnicity, language, religion, and diagnosis) with end‐of‐life characteristics (Phase I enrollment, do‐not‐resuscitate (DNR) orders, hospice utilization, location of death), and trends in palliative care services delivered to pediatric hematology, oncology, and stem cell transplant (SCT) patients.
A SPITZER SEARCH FOR TRANSITS OF RADIAL VELOCITY DETECTED SUPER-EARTHS

Unlike hot Jupiters or other gas giants, super-Earths are expected to have a wide variety of compositions, ranging from terrestrial bodies like our own to more gaseous planets like Neptune. Observations of transiting systems, which allow us to directly measure planet masses and radii and constrain atmospheric properties, are key to understanding the compositional diversity of the planets in this mass range. Although Kepler has discovered hundreds of transiting super-Earth candidates over the past 4 yr, the majority of these planets orbit stars that are too far away and too faint to allow for detailed atmospheric characterization and reliable mass estimates. Ground-based transit surveys focus on much brighter stars, but most lack the sensitivity to detect planets in this size range. One way to get around the difficulty of finding these smaller planets in transit is to start by choosing targets that are already known to host super-Earth sized bodies detected using the radial velocity (RV) technique. Here we present results from a Spitzer program to observe six of the most favorable RV-detected super-Earth systems, including HD 1461, HD 7924, HD 156668, HIP 57274, and GJ 876. We find no evidence for transits in any of their 4.5 μm flux light curves, and place limits on the allowed transit depths and corresponding planet radii that rule out even the most dense and iron-rich compositions for these objects. We also observed HD 97658, but the observation window was based on a possible ground-based transit detection that was later ruled out; thus the window did not include the predicted time for the transit detection recently made by the Microvariability and Oscillations of Stars space telescope.
NILAI-NILAI PENDIDIKAN KARAKTER DALAM NOVEL TANTRI (PEREMPUAN YANG BERCERITA) KARYA COK SAWITRI SEBAGAI ALTERNATIF PEMBELAJARAN SASTRA DI SEKOLAH DASAR

Banyak cara yang bisa dilakukan untuk membentuk siswa yang berkarakter, salah satunya adalah melalui karya sastra. Karya sastra, seperti novel adalah media yang paling efektif untuk mengajarkan nilai-nilai moral, nilai-nilai agama, nilai-nilai budi pekerti, dan nilai-nilai pendidikan karakter. Dewasa ini, banyak novel yang sangat layak bagi siswa, khususnya siswa sekolah dasar untuk lebih mudah memahami nilai-nilai pendidikan karakter. Salah satunya adalah novel Tantri (Perempuan yang Bercerita) karya Cok Sawitri. Cok Sawitri mampu mengolahbahasan kembali cerita-cerita tradisional dan tradisi lisan Ni Diah Tantri yang sangat terkenal di Bali sejak tahun 1915 menjadi sebuah novel modern tanpa melucuti keindahan ajaran moral dan kekayaan nilai-nilai kearifan dari cerita aslinya. Hasil penelitian menunjukkan bahwa (1) nilai-nilai karakter yang terkandung dalam novel Tantri (Perempuan yang Bercerita) ada 18 yaitu, nilai karakter religius, jujur, toleransi, disiplin, kerja keras, kreatif, mandiri, demokratis, rasa ingin tahu, semangat kebangsaan, cinta tanah air, menghargai prestasi, bersahabat atau komunikatif, cinta damai, gemar membaca, peduli lingkungan, peduli sosial, dan tanggung jawab dan (2) Novel Tantri (Perempuan yang Bercerita) sangat cocok untuk dijadikan bahan ajar sastra di sekolah dasar. Tokoh-tokoh yang didominasi oleh binatang tentunya sangat menarik bagi siswa. Nilai-nilai pendidikan karakter yang tertuang di dalam novel ini sangat mudah dipahami dan diterapkan nantinya dalam kehidupan sehari-hari. Siswa sekolah dasar sebagai pondasi kuat dalam membentuk generasi muda Indonesia yang berkarakter, kuat, dan tangguh untuk menghadapi persaingan MEA (Masayarakat Ekonomi Asean). Kata kunci: nilai-nilai pendidikan karakter, novel Tantri (Perempuan yang Bercerita), dan bahan ajar sastra di sekolah dasar.
Stellar MgSiO3 Perovskite: A Shock-transformed Stardust Silicate Found in a Meteorite

We have discovered an isotopically highly anomalous MgSiO3 grain in the ungrouped carbonaceous chondrite Acfer 094 with a perovskite-like crystal structure resembling the dominant high-pressure mineral of the Earth's lower mantle. Oxygen isotopic ratios of the silicate grain are 17O/ 16O = (4.91 ± 0.36) × 10-3 (12 times the solar value) and 18O/16O = (1.36 ± 0.19) × 10-3 (0.4 times the solar value). This signature points to condensation in the ejecta of a ~2 M☉, close-to-solar metallicity red giant branch (RGB) or asymptotic giant branch (AGB) star. Alternatively, the grain could have formed in the ejecta of a nova, in which 17O is highly overabundant. TEM analysis of the grain revealed a high pressure perovskite-like crystal structure not predicted by equilibrium condensation in low-pressure stellar environments. A possible formation scenario is transformation of a silicate precursor triggered by a shock wave, either in the interstellar medium (ISM) or originating from the grain's parent star. Shock waves must thus be considered as a potential mechanism to recrystallize silicates, or even convert them into high-pressure structures. Alternatively, nonequilibrium condensation or crystallization by a chemical vapor deposition (CVD)-like process, also invoked for the formation of nanodiamonds, is a distinct possibility, although more speculative.
Developing a New Generation of Antimicrobial and Bioactive Dental Resins

Dental caries is prevalent, and secondary caries causes restoration failures. This article reviews recent studies on developing a new generation of bioactive resins with anticaries properties. Extensive effects were made to develop new antimicrobial composites, bonding agents, and other resins containing quaternary ammonium methacrylates to suppress plaque buildup and bacterial acid production. The effects of alkyl chain length and charge density and the antimicrobial mechanisms for chlorhexidine, nano-silver, quaternary ammonium methacrylates, and protein-repellent agents were discussed. Synergistic effects of contact-killing and protein-repellent properties were shown to yield the greatest biofilm-inhibition effects. The combination of antimicrobial, protein-repellent, and calcium phosphate nanoparticle remineralization was suggested to provide maximal anticaries effects. In addition, for use orally, cytotoxicity and biocompatibility were important considerations for the new bioactive materials. Furthermore, rather than kill all bacteria, it would be more desirable to modulate the oral biofilm compositions via bioactive resins to suppress cariogenic/pathogenic species and promote benign species. For widespread clinical use of the new antimicrobial and therapeutic materials, whether they would induce bacterial drug resistance needs to be determined, which requires further study. Nonetheless, the new generation of bioactive anticaries resins with therapeutic and biofilm acid-inhibiting properties has the potential to substantially benefit oral health.
Medical end-of-life decisions for children in the Netherlands.

BACKGROUND Most end-of-life decision-making studies have, until now, involved either the general population or newborn infants. OBJECTIVE To assess the frequency of end-of-life decisions preceding child death and the characteristics of the decision-making process in the Netherlands. METHODS Two studies were performed. The first was a death certificate study in which all 129 physicians reporting the death of a child aged between 1 and 17 years in the period August to December 2001 received a written questionnaire; the second was an interview study in which face-to-face interviews were held with 63 physicians working in pediatric hospital departments. RESULTS Some 36% of all deaths of children between the ages of 1 and 17 years during the relevant period were preceded by an end-of-life decision: 12% by a decision to refrain from potentially life-prolonging treatment; 21% by the alleviation of pain or symptoms with a possible life-shortening effect; and 2.7% by the use of drugs with the explicit intention of hastening death. The latter decision was made at the child's request in 0.7% and at the request of the family in 2% of cases. The interview study examined 76 cases of end-of-life decision making. End-of-life decisions were discussed with all 9 competent and 3 partly competent children, with the parents in all cases, with other physicians in 75 cases, and with nurses in 66 cases. CONCLUSIONS While not inconsiderable, the percentage of end-of-life decisions was lower for children than for adults and newborn infants. Most children are not considered to be able to participate in the decision-making process. Decisions are generally discussed with parents and other caregivers and, if possible, with the child.
Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for antifungal susceptibility testing: enhanced ability to detect amphotericin B-resistant Candida isolates

The National Committee for Clinical Laboratory Standards (NCCLS) proposed macrobroth reference method (M27P) for susceptibility testing of yeasts is technically difficult. We evaluated Etest, a simple agar-based MIC methodology, as a possible alternative. In studies of six yeast quality control strains, Etest yielded results identical to those obtained by the NCCLS reference method for both amphotericin B and fluconazole. In studies of 91 clinical Candida isolates, agreement +/- 2 dilutions between the two methods was 95% for fluconazole with phosphate-buffered RPMI 1640 agar and 96 to 97% for amphotericin B with either MOPS (morpholinepropanesulfonic acid)-buffered RPMI 1640 agar or antibiotic medium 3 agar. While the two methods had excellent general agreement, testing of a collection of amphotericin B-resistant isolates demonstrated that, unlike the NCCLS reference method, Etest readily identified the resistant isolates and could do so with a defined medium. Etest is equivalent to the NCCLS proposed method for susceptibility testing of yeasts and superior in its ability to detect amphotericin B resistance.
Structural analysis of antiviral agents that interact with the capsid of human rhinoviruses

X‐Ray diffraction data have been obtained for nine related antiviral agents (“WIN compounds”) while bound to human rhinovirus 14 (HRV14). These compounds can inhibit both viral attachment to host cells and uncoating. To calculate interpretable electron density maps it was necessary to account for (1) the low (∼60percnt;) occupancies of these compounds in the crystal, (2) the large (up to 7.9 Å) conformational changes induced at the attachment site, and (3) the incomplete diffraction data. Application of a density difference map technique, which exploits the 20‐fold noncrystallographic redundancy in HRV14, resulted in clear images of the HRV14:WIN complexes. A real‐space refinement procedure was used to fit atomic models to these maps.
Frequency and antibiotic susceptibility patterns of urinary pathogens in male outpatients in Argentina.

INTRODUCTION Knowledge of the etiology and antimicrobial susceptibility patterns of uropathogens is important for determining the best treatment option. This study aimed to determine the distribution and antibiotic susceptibility patterns of bacterial strains isolated from adult male outpatients. METHODOLOGY Between November 2012 and April 2013, 3,105 community urine samples were analyzed from adult male patients who attended the Laboratorio Hidalgo, Buenos Aires, Argentina. Antimicrobial susceptibility testing was performed by the Kirby-Bauer disc diffusion method. Isolates resistant to third generation cephalosporin were tested for extended-spectrum beta-lactamase (ESBL) production using the double-disk synergy test. RESULTS Of the 3,105 urine samples analyzed, 791 (25.5%) had significant bacteriuria. The frequency of positive urine cultures increased significantly with patient age. Escherichia coli was isolated most frequently (47.3%), followed by Enterococcus faecalis (13.6%), and Klebsiella pneumoniae (11.9%). Gram-negative organisms represented 78.8% of urinary pathogens. The highest activities against Gram-negative bacteria were found with imipenem (99.0%), amikacin (98.1%), ertapenem (94.2%), fosfomycin (90.7%), and piperacillin-tazobactam (90.1%). The frequencies of ESBLs among E. coli, K. pneumoniae, and P. mirabilis were 15.2 %, 22.3%, and 8%, respectively. Fosfomycin, piperacillin-tazobactam, and nitrofurantoin were most effective against Gram-positive organisms. CONCLUSIONS Fosfomycin may be an excellent option for cystitis treatment in patients without risk factors, whereas piperacillin-tazobactam is preferred for the treatment of parenchymatous UTIs, complicated UTIs, and UTIs associated with risk factors. To ensure the optimal selection of antibiotics, physicians should have access to up-to-date information about the local prevalence of antimicrobial resistance.
Can High Plasma Ceruloplasmin Levels Cause Acquired Activated Protein C Resistance?

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Geographic biotype and host-associated local adaptation in a polyphagous species, Lambdina fiscellaria (Lepidoptera: Geometridae) feeding on balsam fir on Anticosti Island, Canada

Abstract The debate about mechanisms underlying the evolution of host specialization by herbivorous insects remains open. Natural selection may act locally and lead to different patterns of geographic variation in life history traits of polyphagous herbivores. The hypothesis of genetically-based trade-offs in offspring performance on different hosts has been proposed but this has rarely been demonstrated. Under laboratory conditions, the biological performance of two populations of the hemlock looper Lambdina fiscellaria (Guenée), a highly polyphagous lepidopteran, was compared when reared on three different tree host species: balsam fir, eastern hemlock and sugar maple. One population originated from Anticosti Island, Québec, Canada, where the insect has evolved without having access to two of the three tree species tested, the other being from the mainland where all tree species are present. When reared on balsam fir foliage, which was naturally available to each population, larvae from Anticosti Island underwent four instars compared with five for the mainland population, indicating the existence of geographic biotypes in L. fiscellaria. When reared on the foliage of non-naturally available host trees, larvae from Anticosti Island had a higher incidence of supernumerary instars. This is a unique example where local adaptation to environmental conditions of an insect herbivore is expressed through a differential number of larval instars. Moreover, the Anticosti Island population showed a higher growth related index on the host available to both populations indicating that a fitness trade-off was the evolutionary process underlying the local adaptation of this population on balsam fir.
Between Autistic Spectrum Disorder (ASD) and Childhood Onset Schizophrenia (COS): A Case Report

Background: Even if childhood-onset of schizophrenia is described in the literature, and there are several case reports of concomitant autism spectrum disorders (ASD) and childhood-onset schizophrenia (COS), early diagnosis remains less the rule than the exception. Method: We report the detailed clinical history of a young woman with ASD and childhood onset schizophrenia from birth to the age of 26. The evolution of the state of the patient is reported together with the diagnosis provided by the caregivers and the pharmacological and psychological treatment. Results: The delay in formulating a diagnosis of concomitant ASD and COS as well as the pressure on academic achievement have contributed to the patient’s sequel of crisis and relapses. The clinical status of the patient has presented a marked improvement when the comorbidity has been acknowledged and properly treated, both pharmacologically and via an appropriate reduction of the stressful proficiency requirements. Conclusion: Early diagnosis of psychiatric comorbidities in ASD allows a more effective therapeutic strategy and the adoption of a psychopedagogical approach adapted to the vulnerability of these patients with respect to stress.
What Is Violence Against Women

Violence against women (VAW) is a prevalent problem with substantial physical and mental health consequences throughout the world, and sound public policy is dependent on having good measures of VAW. This article (a) describes and contrasts criminal justice and public health approaches toward defining VAW, (b) identifies major controversies concerning measurement of VAW, (c) summarizes basic principles in identifying and measuring VAW cases, and (d) recommends changes to improve measurement of VAW. In addition to reviewing recommendations from the Centers for Disease Control and Prevention Workshop on Building Data Systems for Monitoring and Responding to Violence Against Women and the World Health Organization World Report on Violence and Health, the article concludes that changes are needed in the FBI Uniform Crime Reports and National Crime Victimization Survey to improve measurement of rape and sexual assault.
Aridity shapes cyanogenesis cline evolution in white clover (Trifolium repens L.)

Adaptive differentiation between populations is often proposed to be the product of multiple interacting selective pressures, although empirical support for this is scarce. In white clover, populations show adaptive differentiation in frequencies of cyanogenesis, the ability to produce hydrogen cyanide after tissue damage. This polymorphism arises through independently segregating polymorphisms for the presence/absence of two required cyanogenic components, cyanogenic glucosides and their hydrolysing enzyme. White clover populations worldwide have evolved a series of recurrent, climate‐associated clines, with higher frequencies of cyanogenic plants in warmer locations. These clines have traditionally been hypothesized to reflect a fitness trade‐off between chemical defence in herbivore‐rich areas (warmer climates) and energetic costs of producing cyanogenic components in areas of low herbivore pressure (cooler climates). Recent observational studies suggest that cyanogenic components may also be beneficial in water‐stressed environments. We investigated fitness trade‐offs associated with temperature‐induced water stress in the cyanogenesis system using manipulative experiments in growth chambers and population surveys across a longitudinal precipitation gradient in the central United States. We find that plants producing cyanogenic glucosides have higher relative fitness in treatments simulating a moderate, persistent drought stress. In water‐neutral treatments, there are energetic costs to producing cyanogenic components, but only in treatments with nutrient stress. These fitness trade‐offs are consistent with cyanogenesis frequencies in natural populations, where we find clinal variation in the proportion of plants producing cyanogenic glucosides along the precipitation gradient. These results suggest that multiple selective pressures interact to maintain this adaptive polymorphism and that modelling adaptation will require knowledge of environment‐specific fitness effects.