Miracle-dz/UniFAR-FTUs huggingface dataset:
Finite-element method modeling of superconductors: from 2-D to 3-D

A three-dimensional (3-D) numerical modeling technique for solving problems involving superconducting materials is presented. The model is implemented in finite-element method software and is based on a recently developed 3-D formulation for general electromagnetic problems with solid conductors. It has been adapted for modeling of superconductors with nonlinear resistivity in 3-D, characterized by a power-law E-J relation. It has first been compared with an existing and verified two-dimensional (2-D) model: Compared are the current density distribution inside the conductors and the self-field ac losses for different applied transport currents. Second, the model has been tested for computing the current distribution with typical 3-D geometries, such as corner-shaped and twisted superconductors. Finally, it has been used with two superconducting filaments in the presence of external magnetic field for verifying the existence of coupling currents. This effect deals with the finite length of the conductors and cannot be taken into account by 2-D models.
A framework of Universiti Kebangsaan Malaysia patent: UKM patent

A Meta-Search engine is an ideal tool that takes search expressions and sends them out to multiple search engines. It then returns the categorized results to the user. For example, we established a Universiti Kebangsaan Malaysia (UKM) Patent meta-search engine that takes patents from multiple search engines, such as Google patent and Patent Mall. This website allows UKM students to research patents inside Patent Mall, the UKM database and the Google patent search engine. This study focuses on web design and its development using several tools and programming languages, such as open source ASP.Net and SQL Server Database. A few of these are used to retrieve information from search engines, for example, the Google patent application programming interface (API) and Post Query to Patent Mall. In this project, we establish a new framework for the first meta-search engine that specialises in patents, which will minimize useless pages in search results. Additionally, the UKM database contains private university UKM patents. The UKM patent meta-search will extract (or retrieve) these patents depending on a Language-Integrated Query (LINQ) that is used for conveniently extracting and processing patents from the UKM database. Finally, the UKM meta-search is a new solution to the problem of obtaining requested information quickly.
Notice of RetractionRepair Effects of Grape Seed Proanthocyanidin on Damage in Zebrafish Embryos from UVB Irradiation

Various zebrafish (Danio rerio) malformations, such as cyrtosis and short tails, were found in the juvenile stage after the embryos were exposed to ultraviolet B (UVB) (72 mJ/cm2). Grape seed proanthocyandin extract (GSE) (1 mg/ml) was injected into early zebrafish gastrula to protect the embryos against UVB irradiation. The rates of mortality and abnormalities were significantly lower in GSE-treated embryos than in the control group. Total antioxidant capacity (T-AOC) and malonaldehyde (MDA) content of juvenile zebrafish were determined to evaluate the antioxidant status accurately. The results showed that the T-AOC content of early GSE-UVB treated embryos was increased and the MDA content was reduced compared to those exposed to UVB alone. The gene expression pattern in different groups were further investigated by whole-mount in situ hybridization. Caspase-3 was used as a marker for apoptosis. At 24 hpf (hour post fertilization) and 36 hpf stages, the expression of caspase-3 was enhanced after UVB irradiation and GSE injection reduced the expression of caspase-3 after UVB irradiation. These results demonstrated that GSE alleviated the amount of damage following UVB irradiation in zebrafish embryos. This provided evidence for GSE's further application as an antioxidant.
The accuracy of 3D image navigation with a cutaneously fixed dynamic reference frame in minimally invasive transforaminal lumbar interbody fusion

Objective: In contrast to preoperative image-based 3D navigation systems, which require surgeon-dependent registration, an intraoperative cone-beam computed tomography (cb-CT) image-based 3D navigation system allows automatic registration during the acquisition of 3D images intraoperatively. Thus, the need for spinal exposure for point matching is obviated, making a cb-CT image-based navigation system ideal for use in minimally invasive spinal procedures. Conventionally, the dynamic reference frame (DRF) is mounted to an adjacent spinous process or iliac bone through a separate incision. However, the close proximity of the DRF to the surgical area may result in its interfering with the surgical procedure or causing streak artifacts on the navigation images. Cutaneous placement of the DRF overlying the sacral hiatus is one possible solution to these problems, but such a placement does not provide a solid bony fixation point and is distant from the surgical area, both of which factors may hinder the accuracy of the navigation. The purpose of this study was to evaluate the accuracy of a novel idea for DRF placement in a series of mini-open transforaminal lumbar interbody fusion (TLIF) procedures performed with intraoperative cb-CT image-based 3D navigation. Methods: From June 2009 to December 2009, 20 patients underwent mini-open TLIF for a total 82 pedicle screws placed in the lumbar spine with cutaneous placement of the DRF overlying the sacral hiatus. The pedicle screws were inserted under navigational guidance using cb-CT data acquired intraoperatively with a Medtronic O-arm. Screw positions were subsequently checked with a final intraoperative cb-CT scan. Nineteen patients underwent single-level fusion (8 at L4–5, 6 at L5–S1, 4 at L3–4, and 1 at L2–3) and one patient underwent two-level fusion (from L3–5). Results: There were 4 (4.9%) pedicle perforations greater than 2 mm out of the 82 pedicle screw insertions in the 20 patients. Two of these breached screws were repositioned and confirmed to be in place with a final intraoperative cb-CT. There were no complications of neural injury associated with these perforations. Conclusion: A cutaneously mounted DRF overlying the sacral hiatus provides accuracy in intraoperative 3D image guided navigation for mini-open TLIF that is comparable to that obtained in other reported series using a fixed bony attachment point for the DRF.
Design of Multiband UWB Planarized Monopole Using DMS Technique

A variation of the novel technique called defected microstrip structure (DMS) is employed to enlarge the bandwidth of a planarized ultrawideband (UWB) monopole. It is demonstrated that introducing a defect in the feeding microstrip line, the lower bandwidth limit is lowered without affecting the antenna gain and radiation pattern. The bevel technique in the ground plane near to the feeding point is used to increase the highest bandwidth limit. By using these techniques, a 50 mm times 50-mm planarized omnidirectional antenna was developed, achieving a voltage standing wave ratio (VSWR) < 2 from 2.1 to 12.3 GHz
Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand.

AIMS To assess the antiischaemic efficacy and tolerability of the metabolic agent trimetazidine in combination with metoprolol in patients with stable effort angina. METHODS This was a randomized, multicentre, double-blind, placebo-controlled parallel group study. A total of 426 male and female patients with stable, effort-induced angina and documented coronary artery disease received either placebo or trimetazidine 20 mg three times daily in addition to metoprolol 50 mg twice daily. Treadmill exercise tests were performed at weeks (-1), 0, 4 and 12. RESULTS After 12 weeks, there were significantly greater improvements in the metoprolol + trimetazidine group than in the metoprolol + placebo group in: time to 1 mm ST segment depression, total workload, time to onset of angina, maximum ST segment depression, mean weekly number of angina attacks, mean weekly nitrate consumption, and grade of anginal pain. There was no evidence of any development of tolerance to trimetazidine. The tolerability of trimetazidine was excellent. CONCLUSIONS Therapy with trimetazidine plus metoprolol produced significant improvements in exercise stress tests and the symptoms of angina relative to metoprolol alone. With its metabolic effect, devoid of any haemodynamic action, trimetazidine is useful for combination therapy in patients with stable angina insufficiently controlled by monotherapy with a beta-blocker.
The Diffusion and Enzymic Hydrolysis of Monofluorophosphate in Dental Plaque

Although the ability of dental plaque to hydrolyze sodium monofluorophosphate (MFP) has been known for some time, its effect on the F- concentration at the plaque-enamel interface is undefined. We have determined enzyme kinetic values for MFP hydrolysis and diffusion coefficients so that the penetration and degradation of MFP in plaque can be modeled by computer. The KM and Vmax values for natural human plaque were 1.77 mmol/L and 41.4 nmol/min/mg protein, respectively, at pH 8.0. At pH 6.0, the Vmax was lower, 15.6 nmol/min/mg, but KM was not significantly different. Competitive inhibition by orthophosphate gave a Ki of 4.55 mmol/L. The diffusion coefficient for MFP in artificial plaque was 1.91 x 10-6 cm2/sec. When these data were used for mathematical modeling of the effects of rinsing with MFP and F-solutions, compared with an equivalent NaF application, the concentration of F- from MFP was lower at the inner surface of plaque, and the peak occurred later. Both pH and plaque thickness had a marked effect on the amount of MFP that could penetrate: At pH 8.0, almost none reached the inner surface of a 1-mm-thick plaque intact. At pH 6.0, however, more MFP was able to penetrate, due to lower MFPase activity. While MFP diffusion is inherently slower than that of F-, enzymic degradation increases the gradient for inward diffusion. If the conventional view that MFP in toothpaste acts as a source of F- is true, then MFP toothpaste should be formulated to optimize MFPase activity in dental plaque.
Labeling of hematopoietic stem and progenitor cells in novel activatable EGFP reporter mice

Summary: Conditional activation and inactivation of genes using the Cre/loxP recombination system is a powerful tool for the analysis of gene function and for tracking cell fate. Here we report a novel silent EGFP reporter mouse line generated by enhancer trap technology using embryonic stem (ES) cells. Following transfection with the silent EGFP reporter construct, positive ES cell clones were treated with Cre recombinase. These “activated clones” were then further selected on the basis of ubiquitous EGFP expression during in vitro differentiation. The parental “silent” clones were then used for generating mice. Upon Cre‐mediated activation in ovo tissues tested from these mice express EGFP. Long‐term, strong and sustainable expression of EGFP is observed in most myeloid and lymphoid cells. As shown by in vivo transplantation assays, the majority of hematopoietic stem cells (HSCs) and spleen colony‐forming units (CFU‐S) reside within the EGFP positive fraction. Most in vitro colony‐forming units (CFU‐Cs) isolated from bone marrow also express EGFP. Thus, these reporter mice are useful for the analysis of Cre‐mediated recombination in HSCs and hematopoietic progenitor cells. This, in combination with the high accessibility of the loxP sites, makes these mice a valuable tool for testing cell/tissue‐specific Cre‐expressing mice. genesis 36:168–176, 2003. © 2003 Wiley‐Liss, Inc.
Advances in Brief Genomic Structure of the Human ING 1 Gene and Tumor-specific Mutations Detected in Head and Neck Squamous Cell Carcinomas 1

We characterized the genomic structure of the humanING1 gene, a candidate tumor suppressor gene, and found that the gene has three exons. We also demonstrated that four mRNA variants were transcribed from three different promoter regions. Of 34 informative cases of head and neck squamous cell carcinoma, 68% of tumors showed loss of heterozygosity at chromosome 13q33–34, where the ING1 gene is located. Here we present the first report that three missense mutations and three silent changes were detected in the ING1 gene in 6 of 23 tumors with allelic loss at the 13q33–34 region. These missense mutations were found within the PHD finger domain and nuclear localization motif in ING1 protein, probably abrogating the normal function.
The Impact of Rest Breaks on Temporal Trends in Injury Risk

This study examined the impact of rest breaks on temporal trends in industrial accident risks in an attempt to replicate earlier findings of a linear increase in risk as a function of elapsed time on task. In two separate studies, the trend in work‐related injuries were studied in relation to the timing of rest breaks. In study one, comparisons were made between on‐ and off‐track workers on weekly rotating three‐shift systems operating in a large engineering company. Records of on‐duty injuries that occurred over 12 months were examined (N=4645 incidents). Study two involved interviewing patients who had suffered work‐related hand injuries in a variety of occupational settings (N=407 patients). Hierarchical log linear analysis was used in both studies. In study one, risk increased from the first to the second half‐hour of continuous work following a break, but then remained relatively constant in subsequent half‐hour periods, although there was a fall in the third half‐hour for on‐track workers. In some of the data, there was also a decrease in risk in the period leading up to the end of a work period. There was a sharp decline in reported injuries toward the very end of a shift, but otherwise the observed trends did not differ between successive periods of continuous work or between morning, afternoon, and night shifts. In study two, risk increased from the first to the second half‐hour of continuous work and then remained relatively constant in the third half‐hour. The contrast between the current and previous findings may be due to the relatively unique work environment of the previous study. It is suggested that the current trends reflect the effects of working in a relatively unconstrained task environment, and that causes other than fatigue may underlie the trends observed in both the previous and current studies.
Affective and Cognitive Decision-Making in Adolescents

Adolescents demonstrate impaired decision-making in emotionally arousing situations, yet they appear to exhibit relatively mature decision-making skills in predominately cognitive, low-arousal situations. In this study we compared adolescents' (13–15 years) performance on matched affective and cognitive decision-making tasks, in order to determine (1) their performance level on each task and (2) whether performance on the cognitive task was associated with performance on the affective task. Both tasks required a comparison of choice dimensions characterized by frequency of loss, amount of loss, and constant gain. Results indicated that in the affective task, adolescents performed sub-optimally by considering only the frequency of loss, whereas in the cognitive task adolescents used relatively mature decision rules by considering two or all three choice dimensions. Performance on the affective task was not related to performance on the cognitive task. These results are discussed in light of neural developmental trajectories observed in adolescence.
Pseudomastus deltaicus gen. et sp.n. (Polychaeta: Capitellidae) from a shallow water bay in the North‐ Western Mediterranean Sea

Specimens of Pseudomastus deltaicus gen. et sp.n. (Capitellidae), were collected from muddy bottoms in Els Alfacs Bay (Ebre Delta), a semi‐enclosed shallow water area. The main diagnostic characteristics are the possession of 12 thoracic setigers, of which the first 10 have only capillary setae and the last two have capillary notosetae and neuropodial hooded hooks, and presence of branchiae in the abdominal region. Pygidium bearing three anal cirri.
Characterization of a partially purified methanol-soluble heat-stable Escherichia coli enterotoxin in infant mice

While studying the involvement of cyclic adenosine 3',5'-monophosphate (cAMP) in the fluid secretion caused by heat-stable enterotoxin (ST) from Escherichia coli P16 in infant mice, it was noted that the culture filtrate containing ST also contained large amounts of cAMP. The present paper details attempts to obtain a cAMP-free ST preparation. The organisms were grown in a defined medium, and the heated culture filtrate was concentrated by reverse osmosis. After methanol extraction of the filtrate, which removed 80% of the nonactive solids, the methanol-soluble ST was further purified by gel filtration through a Sephadex G-10 column. The first fraction recovered after gel chromatography contained ST with a negligible amount of cAMP. Treatment with methanol did not adversely affect the enterotoxic activity. Certain parameters of the infant mouse model have been investigated, and using our ST preparation it has been found that animals remain responsive up to 15 days of age with an optimum assay time of 2 h after toxin challenge.
Lobster (Panulirus argus) Hepatopancreatic Trypsin Isoforms and Their Digestion Efficiency

It is well known that crustaceans exhibit several isoforms of trypsin in their digestive system. Although the number of known crustacean trypsin isoforms continues increasing, especially those derived from cDNA sequences, the role of particular isoenzymes in digestion remains unknown. Among invertebrates, significant advances in the understanding of the role of multiple trypsins have been made only in insects. Since it has been demonstrated that trypsin isoenzyme patterns (phenotypes) in lobster differ in digestion efficiency, we used this crustacean as a model for assessing the biochemical basis of such differences. We demonstrated that the trypsin isoform known to be present in all individuals of Panulirus argus has a high catalytic efficiency (kcat/Km ) and is the most reactive toward native proteinaceous substrates, whereas one of the isoforms present in less efficient individuals has a lower kcat and a lower kcat/Km, and it is less competent at digesting native proteins. A fundamental question in biology is how genetic differences produce different physiological performances. This work is the first to demonstrate that trypsin phenotypic variation in crustacean protein digestion relies on the biochemical properties of the different isoforms. Results are relevant for understanding trypsin polymorphism and protein digestion in lobster.
Stage 1 : develop a new framework and items for measuring indicators of quality nursing work environment

PhD, RN, Associate Professor, School of Nursing, National Taipei University of Nursing and Health Sciences, and Consultant, Department of Nursing, Shuang Ho Hospital, Taipei Medical University & MSN, RN, Endowed Professor, College of Nursing, Taipei Medical University, and President, National Union of Nurses’ Associations, ROC & PhD, RN, Supervisor, Taipei Cancer Center, and Adjunct Assistant Professor, School of Nursing, Taipei Medical University.
Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously

This was a proof-of-concept computational fluid dynamics (CFD) study designed to identify atherosclerotic changes in intracranial aneurysms. We selected 3 patients with multiple unruptured aneurysms including at least one with atherosclerotic changes and investigated whether an image-based CFD study could provide useful information for discriminating the atherosclerotic aneurysms. Patient-specific geometries were constructed from three-dimensional data obtained using rotational angiography. Transient simulations were conducted under patient-specific inlet flow rates measured by phase-contrast magnetic resonance velocimetry. In the postanalyses, we calculated time-averaged wall shear stress (WSS), oscillatory shear index, and relative residence time (RRT). The volume of blood flow entering aneurysms through the neck and the mean velocity of blood flow inside aneurysms were examined. We applied the age-of-fluid method to quantitatively assess the residence of blood inside aneurysms. Atherosclerotic changes coincided with regions exposed to disturbed blood flow, as indicated by low WSS and long RRT. Blood entered aneurysms in phase with inlet flow rates. The mean velocities of blood inside atherosclerotic aneurysms were lower than those inside nonatherosclerotic aneurysms. Blood in atherosclerotic aneurysms was older than that in nonatherosclerotic aneurysms, especially near the wall. This proof-of-concept study demonstrated that CFD analysis provided detailed information on the exchange and residence of blood that is useful for the diagnosis of atherosclerotic changes in intracranial aneurysms.
Forecasting Economic Activity from Yield Curve Factors

This paper provides clear-cut evidence that the slope and curvature factors of the term structure of interest rates (yield curve) contain more information about future changes in economic activity than the term spread itself, often used in the literature as a predictive regressor of economic activity. These two factors reflect different information about future economic activity, which is smoothed out by the term spread. The paper shows that the slope factor has predictive power on future economic activity over longer horizons ahead, and thus may be interpreted as reflecting future business cycle conditions. On the other hand, the curvature factor, which enters the term spread with opposite sign than the slope factor, has predictive power on shorter movements of future economic activity which may be associated with changes in the current stance of monetary policy. These results hold for a number of world developed economies.
Adaptive Finite Element Methods For Optimal Control Of Second Order Hyperbolic Equations

Abstract In this paper we consider a posteriori error estimates for space-time finite element discretizations for optimal control of hyperbolic partial dierential equations of second order. It is an extension of Meidner and Vexler (2007), where optimal control problems of parabolic equations are analyzed. The state equation is formulated as a first order system in time and a posteriori error estimates are derived separating the in uences of time, space, and control discretization. Using this information the accuracy of the solution is improved by local mesh refinement. Numerical examples are presented. Finally, we analyze the conservation of energy of the homogeneous wave equation with respect to dynamically in time changing spatial meshes.
ON ALGEBRAIC PROPERTIES OF TOPOLOGICAL FULL GROUPS

In the paper we discuss the algebraic structure of topological full group [[T ]] of a Cantor minimal system (X,T ). We show that the topological full group [[T ]] has the structure similar to a union of permutational wreath products of group Z. This allows us to prove that the topological full groups are locally embeddable into finite groups; give an elmentary proof of the fact that group [[T ]]′ is infinitely presented; and provide explicit examples of maximal locally finite subgroups of [[T ]]. We also show that the commutator subgroup [[T ]]′, which is simple and finitely-generated for minimal subshifts, is decomposable into a product of two locally finite groups and that the groups [[T ]] and [[T ]]′ possess continuous ergodic invariant random subgroups.