Miracle-dz/UniFAR-FTUs huggingface dataset:
A decrease in conjunction error rates across lags on a continuous recognition task: A robust pattern

In four experiments, the lag retention interval from parent words (e.g., blackmail, jailbird) to a conjunction word (blackbird) was manipulated in a continuous recognition task. Alterations to the basic procedure of Jones and Atchley (2002) were employed in Experiments 1 and 2 to bolster recollection to reject conjunction lures, yet conjunction error rates still decreased across lags of 1 to 20 words. Experiment 3 and a multiexperiment analysis examined the increments of forgetting in familiarity across lags of 1–20 words. Finally, in Experiment 4, participants attempted to identify conjunction probes as “old”, and the data were contrasted with those from a previous experiment (Jones & Atchley, 2002, Exp. 1), in which participants attempted not to identify conjunction probes as “old”. In support of earlier findings, the decrease in familiarity across lags of 1–20 words appears robust, with a constant level of weak recollection occurring for parent words.
Prevalence of abusive encounters in the workplace of family physicians: a minor, major, or severe problem?

OBJECTIVE To examine the career prevalence of abusive encounters for family physicians in Canada. DESIGN A 7-page cross-sectional mailed survey in English and French. SETTING Canada. PARTICIPANTS A total of 3802 randomly selected practising family physicians who were members of the College of Family Physicians of Canada. MAIN OUTCOME MEASURES Demographic characteristics of survey participants, career prevalence of abusive encounters, and perpetrators of abuse. MAIN FINDINGS Twenty percent (20.4%) of the surveys (n = 774) were returned. Of the respondents, 44% were men and 56% were women. Most were in private practice in urban settings. The average number of years in practice was 15. The career prevalence of abusive encounters was divided into "minor," "major," and "severe" incidents. Of all the respondents, 98% had experienced at least 1 incident of minor abuse, 75% had experienced at least 1 incident of major abuse, and 39% had experienced at least 1 incident of severe abuse. Using chi(2) analysis, a number of demographic variables were found to be significantly associated with abuse including the physician's race and sex. Patients were the most common perpetrators of abuse. Ninety percent of family physicians surveyed reported that they had been abused by patients, while 70% reported that they had been abused by family members of patients. CONCLUSION Approximately 2 in 5 family physicians surveyed were subjected to a considerable amount of severe abuse during practice. Abuse in the office setting might have grave consequences for the health and well-being of the victimized physicians and might hinder service retention where the risk of abuse is greatest.
New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis.

BACKGROUND The reduced glomerular filtration rate in the advanced stages of chronic kidney disease (CKD) leads to plasma accumulation of uraemic retention solutes including proteins. It has been hypothesized that these changes may, at least in part, be responsible for CKD-associated morbidity and mortality. However, most studies focused on the role of individual proteins, while a holistic, large-scale, integrative approach may generate significant additional insight. METHODS In a discovery study, we analysed the plasma proteome of patients with stage 2-3 CKD (n = 14) and stage 5 CKD with haemodialysis (HD) (n = 15), using high-resolution LC-MS/MS analysis. Selected results were validated in a cohort of 40 patients with different CKD stages with or without HD, using ELISA. RESULTS Of a total of 2054 detected proteins, 127 displayed lower, while 206 displayed higher abundance in the plasma of patients on HD. Molecular pathway analysis confirmed the modification of known processes involved in CKD complications, including decreased haemostasis and increased inflammation, complement activation and vascular damage. In addition, we identified the plasma increase during CKD progression of lysozyme C and leucine-rich alpha-2 glycoprotein, two proteins related to vascular damage and heart failure. High level of leucine-rich alpha-2 glycoprotein was associated with higher mortality in stage 5 CKD patients on HD. CONCLUSIONS This study provides for the first time a comprehensive assessment of CKD plasma proteome, contributing to new knowledge and potential markers of CKD. These results will serve as a basis for future studies investigating the relevance of these molecules in CKD associated morbidity and mortality.
Polymorphism of the Prolactin Gene and Its Relationship with Milk Production in Gir and Kankrej Cattle

Background: The aim of this study was to detect allelic and genotypic frequencies of prolactin (PRL) gene in Gir (200) and Kankrej (100) cattle and to analyze milk production traits of tested cattle on their PRL genotypes. Materials and Methods: The 156 bp fragment located in exon 3 was amplified using polymerase chain reaction-restriction fragments length polymorphism technique. Results: Allele frequencies in the studied breed were A = 0.52 and B = 0.48. Means and standard deviations for milk yield and fat content (%) were 3811.6 ± 462.1 and 3.99 ± 0.18 for the AA genotype, 3514.9 ± 450.8 and 4.16 ± 0.33 for the AB genotype, and 3388.8 ± 423.3 and 4.34 ± 0.11 for the BB genotype, respectively, in Gir cattle. Similarly, for Kankrej cattle, means and standard deviations for milk yield and fat content (%) were 2007.8 ± 246.3 and 4.05 ± 0.16 for the AA genotype, 1846.14 ± 133.4 and 4.10 ± 0.156 for the AB genotype, and 1767.7 ± 186.4 and 4.30 ± 0.178 for the BB genotype, respectively, in Kankrej cattle. Conclusion: This study showed differences in milk traits among PRL genotypes of Gir and Kankrej cattle.
Adult Human Primary Cardiomyocyte-Based Model for the Simultaneous Prediction of Drug-Induced Inotropic and Pro-arrhythmia Risk

Cardiac safety remains the leading cause of drug development discontinuation. We developed a human cardiomyocyte-based model that has the potential to provide a predictive preclinical approach for simultaneously predicting drug-induced inotropic and pro-arrhythmia risk. Methods: Adult human primary cardiomyocytes from ethically consented organ donors were used to measure contractility transients. We used measures of changes in contractility parameters as markers to infer both drug-induced inotropic effect (sarcomere shortening) and pro-arrhythmia (aftercontraction, AC); contractility escape (CE); time to 90% relaxation (TR90). We addressed the clinical relevance of this approach by evaluating the effects of 23 torsadogenic and 10 non-torsadogenic drugs. Each drug was tested separately at four multiples of the free effective therapeutic plasma concentration (fETPC). Results: Human cardiomyocyte-based model differentiated between torsadogenic and non-torsadogenic drugs. For example, dofetilide, a torsadogenic drug, caused ACs and increased TR90 starting at 10-fold the fETPC, while CE events were observed at the highest multiple of fETPC (100-fold). Verapamil, a non-torsadogenic drug, did not change TR90 and induced no AC or CE up to the highest multiple of fETPCs tested in this study (222-fold). When drug pro-arrhythmic activity was evaluated at 10-fold of the fETPC, AC parameter had excellent assay sensitivity and specificity values of 96 and 100%, respectively. This high predictivity supports the translational safety potential of this preparation and of the selected marker. The data demonstrate that human cardiomyocytes could also identify drugs associated with inotropic effects. hERG channel blockers, like dofetilide, had no effects on sarcomere shortening, while multi-ion channel blockers, like verapamil, inhibited sarcomere shortening. Conclusions: Isolated adult human primary cardiomyocytes can simultaneously predict risks associated with inotropic activity and pro-arrhythmia and may enable the generation of reliable and predictive data for assessing human cardiotoxicity at an early stage in drug discovery.
Citric Acid Production by Aspergillus niger Using Molasses and Pumpkin as Substrates

3 Abstract: Two starchy substrates like pumpkin and cane molasses were selected for citric acid fermentation by using gamma ray induced mutant strains of 14/20 and 79/20 of A. niger under surface culture condition. Citric acid production was also different with various fermentation media by A. niger 14/20 and 79/20 strains. It was found to increase with the increase of fermentation period and maximum citric acid was found on day 13. In the presence of Prescott salt citric acid production was found lower than the absence of Prescott salt. Without Prescott salt highest values of citric acid production was found in mixed fermentation medium which were about 14.86 mg/ml and 14.44 mg/ml for A. niger 14/20 and 79/20 strains respectively, lowest production of citric acid was found in molasses medium for A. niger 14/20 and 79/20 strains were 7.72 and 7.57 mg/ml respectively. Whereas in the presence of Prescott salt, lowest production of citric acid in Pumpkin medium was found 2.86 mg/ml for A. niger 14/20 and 2.7 mg/ml for A. niger 79/20. Highest amount of citric acid was produced in molasses medium 4.88 mg/ml for A. niger 14/20 on day 13 with the presence of Prescott salt whereas 4.75 mg/ml for A. niger 79/20 strains respectively. Mixed substrate prepared with molasses and pumpkin media was proved to be the best and potential for citric acid production.
Social desirability, social intelligence and self-rated oral health status and behaviours.

OBJECTIVES Our aim was to examine the impact of social intelligence and social desirability on students' self-rated oral health and oral health-related behaviors. METHOD AND MATERIALS The present study sample consisted of 217 first year dental students. The questionnaire included information about socio-demographic factors, behavioral factors, self-reported oral health status, social intelligence (Tromsø Social Intelligence Scale-TSIS) and social desirability (Marlowe-Crowne Social Desirability Scale short form C). RESULTS Social desirability was correlated with age, perceived dental health, current nontreated caries, toothache last time, self-reported gum bleeding and reason for the dental visit. Other measures were not influenced by social desirability: current extracted teeth, satisfaction with appearance of own teeth, self-reported gingival condition, daily toothbrushing, flossing, mouthrinse and dental visit frequency. It was revealed that participants with stronger social intelligence tended to evaluate as excellent their self rated oral health status, to be less dissatisfied by the appearance of their teeth, not to have untreated dental decays, extracted teeth (others than third molars) or gingival bleeding, to brush their teeth more than twice a day, to use everyday dental floss and to visit their dentist mainly for check-up or for tooth cleaning and scaling. Multiple regression analyses models demonstrated significant contributions of social awareness, social skills and social information processing were observed to oral health behaviours: toothbrushing, flossing and dental visit frequency. CONCLUSION The results support the view that social desirability should be considered as a factor which may impact measurements and decisions, while social intelligence has a significant association with oral health behaviours.
Assessing children’s speech using picture-naming: The influence of differing phonological variables on some speech outcomes

Abstract Purpose: Sometimes, children’s speech is judged as typical on picture-naming tests and not on other speech tests, even other picture-naming tests. This study attempts to explain this observation by examining the impact of increasing the numbers of polysyllabic words in a picture-naming test on the outcomes of percentages of consonants and vowels correct and phonological processes. Method: The participants were 283 randomly sampled, typically-developing children, aged 3–7-years. These Australian English speakers named pictures, yielding ∼166 selected words, varied for syllable number, stress and shape, which repeatedly sampled all consonants and vowels of Australian English. Result: Most mismatches occurred in di- and polysyllabic words, with few in monosyllabic words: the usual words in picture-naming speech tests. Significant age effects existed for percentages of consonants and vowels correct and for 12 of the 16 phonological processes investigated. Many age effects were present at 7 years; later than often reported. Conclusion: These findings imply that additional di- and polysyllabic words add value to routine speech testing. Further, children, especially school children, who “pass” speech tests dominated by monosyllabic words may benefit from further examination of their productions of di- and polysyllabic words before finalizing clinical judgements about their speech status.
Use of automated riboprinter and pulsed-field gel electrophoresis for epidemiological studies of invasive Haemophilus influenzae in Taiwan.

A total of 87 invasive isolates of Haemophilus influenzae isolated throughout Taiwan from 1994 to 1998 was collected; 57 were from children <14 years old. In all, 60.9% of isolates were resistant to ampicillin and produced beta-lactamase. Ribotyping revealed six different profiles in 55 isolates of type b, nine profiles in 10 isolates of non-type b and 12 profiles in 22 isolates of non-typable H. influenzae. Among isolates from 35 cases of meningitis, 30 (86%) were in ribogroups 1, 2 and 3 with >90% genetic similarity. Compared with all the other ribogroups, ribogroups 1, 2 and 3, which encompassed all H. influenzae type b, were significantly more prevalent as a cause of meningitis in children <14 years old. Further subtyping of the predominant ribogroup by pulsed-field gel electrophoresis (PFGE) identified differences of 0-6 bands among these isolates of ribogroup 1, which indicated distant relatedness. Automated ribotyping was found to be a useful method and was less time-consuming for molecular epidemiology studies of H. influenzae. PFGE is suggested as an addition to ribotyping to improve discrimination if H. influenzae type b is involved. Differentiating ribogroups between type b and non-type b H. influenzae by genotyping may help to understand the molecular characteristics of outbreaks, endemicity and value of vaccination. According to the results of ribotyping and PFGE, it seems possible that spread of invasive H. influenzae type b had occurred and ribotyping confirmed that there was no clonal spread of non-type b H. influenzae in Taiwan.
Maternal prenatal attitudes and postnatal breast-feeding behaviours in rural Bangladesh

Abstract Objective To assess the relationships between maternal breast-feeding intention, attitudes, self-efficacy and knowledge at 7 months’ gestation with exclusive or full breast-feeding at 3months postpartum. Design Prospective cohort study with structured home interviews during pregnancy and 3 months after delivery. Setting Two rural sub-districts of Kishoreganj district, Bangladesh. Subjects Mother–infant dyads. Results Over 80 % of 2178 pregnant women intended to exclusively breast-feed (EBF). Maternal positive attitudes, self-efficacy and knowledge about breast-feeding were positively associated with EBF intention (all P<0·05). All mothers except one reported initiating breast-feeding and 99·6 % of children were still breast-fed at 3 months. According to 24 h dietary recalls, we categorized 985 (45·2 %) infants as EBF at 3 months (47·8 % among mothers with EBF intention; 31·7 % among mothers with no EBF intention; P<0·05) and 551 (25·3 %) infants as predominantly breast-fed at 3 months (24·2 % among mothers with EBF intention; 30·8 % among mothers with no EBF intention; P<0·05). Prenatal EBF intention was associated with EBF (OR=1·48, 95 % CI 1·14, 1·91) and with full breast-feeding (OR=1·34, 95 % CI 1·04, 1·72) at age 3 months. EBF at age 3months was not associated with maternal breast-feeding knowledge, attitudes or self-efficacy. Conclusions Despite widespread expressed maternal EBF intention and universal breast-feeding initiation, prevalence of both exclusive and full breast-feeding at 3months remains lower than WHO recommendations. EBF intention predicts breast-feeding behaviours, suggesting the importance of prenatal counselling to improve infant feeding behaviours.
Comparative Interinstrument Reliability of Uniaxial and Triaxial Accelerometers in Free-Living Conditions

The aim of this study was to measure the inter-instrument reliability of the ActiGraph and RT3 accelerometers in free-living conditions. 15 healthy adults wore eight ActiGraph accelerometers and five RT3 accelerometers fastened to their back with an elastic belt and adjustable buckle in free-living conditions. For both accelerometers, the inter-instrument coefficient of variation (CV) decreased with increasing physical activity intensity. The inter-instrument CV of the ActiGraph (3% to 10.5%) was significantly lower than that of the RT3 (12.6% to 35.5%; p < 0.05). This finding demonstrates that the ActiGraph has higher inter-instrument reliability than the RT3. For both accelerometers, the inter-instrument reliability was higher for moderate and vigorous physical activity, the two intensities recommended for public health purposes. Studies using these devices can be compared with a low risk of misclassification of participants who meet the recommendation to perform moderate to vigorous physical activity.
On power factor improvement by lossless linear filters in the nonlinear nonsinusoidal case

Recently, it has been established that the problem of power factor compensation (PFC) for nonlinear loads with non-sinusoidal source voltage can be recast in terms of the property of cyclodissipativity. Using this framework we study the PFC for nonlinear loads containing a memoryless nonlinearity. We show that the power factor is improved by lossless linear time invariant filter if and only if a certain equalization condition between the weighted powers of inductors and capacitors of the load is ensured.
Effect of Ozone Therapy Dressing Technique on the Healing Process of Recent 2nd Degree Burns

Burn injuries are one of the major health problems throughout the world. The problem of infection in burn wound is considered the cause of death in burned patients. Aim of the study: To determine the effectiveness of ozone therapy dressing technique on the healing process of recent 2nd degree burns. Material and Methods: A convenience sample of 40 burned patients second burn wound injuries included in the study, they were divided randomly into two groups: study and control group, 20 patients in each group. The study group, its burn sites were dressed by ozone dressing technique by the researcher, the control group its burn sites were dressed by conventional dressing technique by the hospital staff according to the hospital routine, two tools were used to fulfil Tool I: burn wound assessment and Tool II burn wound dressing evaluation tool the objective of the study. Results: significant difference was found between the two dressing techniques and wound pain, also a significant difference was found between study and control group in relation to healing process. Healing occurs in the study group after second, third week and before discharge. Conclusion: Although the two dressing techniques (ozone dressing technique and conventional dressing techniques) were effective on healing process of 2nd degree burns, but ozone had faster healing effect than conventional dressing, it so represent the lowest and cost of dressing and days of hospital stay decreased. Recommendation: ozonated water and ozonated olive oil recommend to be used on a daily based time to treat 2nd degree of burn wound. As well as training of nurses how to use ozone therapy and the technique for its using.
[Knowledge and practices concerning taeniasis-cysticercosis in Colombian pig-breeders].

OBJECTIVE Describing knowledge and practices regarding taeniasis-cysticercosis and cysticercosis prevalence in the village of Andagoya, Colombia. METHODS The study design was qualitative and quantitative. The study population consisted of pig breeders and their families, local groups and pigs. RESULTS Study participants had partial knowledge of the taeniasis-cysticercosis complex. They considered taeniasis to be an illness resulting from faecal transmission and not caused by becoming infected with cysticercosis after consuming pork. Pig breeding is not carried out in confined conditions and, although breeders know the right measures for controlling some parasitic illnesses, these practices are not observed. There was 8.7% presence of T. solium antibodies in pig breeders and their relatives and 20.9% in the pigs. CONCLUSIONS An educational programme aimed at raising the population's awareness of the taeniasis-cysticercosis complex cycle should be developed; this will facilitate control measures being applied.
Cardiac telocytes: serial dynamic images in cell culture

Telocytes (TC) are interstitial cells with telopodes (Tp). These prolongations (Tp) are quite unique: very long (several tens of micrometres) and very thin (≤0.5 μm), with moniliform aspect: thin segments (podomeres) alternating with dilations (podoms). To avoid any confusion, TC were previously named interstitial Cajal‐like cells (ICLC). Myocardial TC were repeatedly documented by electron microscopy, immunohistochemistry and immunofluorescence. TC form a network by their Tp, either in situ or in vitro. Cardiac TC are (completely) different of ‘classic’ fibroblasts or fibrocytes. We hereby present a synopsis of monitoring, by time‐lapse videomicroscopy, of Tp network development in cell culture. We used a protocol that favoured interstitial cell selection from adult mouse myocardium. Videomicroscopy showed dynamic interactions of neighbour TC during the network formation. During their movement, TC leave behind distal segments (podomeres) of their Tp as guiding marks for the neighbouring cells to follow during network rearrangement.
Contribution à l'étude du genre Armeria Willd. (Plumbaginaceae). III. Clé générale des taxons français.

ResumeDans le cadre d'une etude biosystematique du genre Armeria, l'auteur reunit, sous forme de cle, un ensemble de resultats relatifs a l'etude de la variabilite des caracteres morphologiques des differents taxons francais, a la fois au niveau des populations et au niveau des individus soumis a la culture experimentale.
On estimating bounds of the quiescent current for I/sub DDQ/ testing

The quiescent current (I/sub DDQ/) consumed by an IC is a good indicator of the presence of a large of defects. However, the effectiveness of I/sub DDQ/ testing requires appropriate discriminability of defective and defect-free currents and hence it becomes necessary to estimate the currents involved in order to design the I/sub DDQ/ sensing circuitry. In this work, we present a method to estimate the non-defective I/sub DDQ/ consumption based on a hierarchical approach using layout (device), electrical (cell) and logic (circuit) information. The maximum of the defect-free I/sub DDQ/ is obtained with a technique based on ATPG. The results show that the proposed method gives the maximum defect-free I/sub DDQ/ for small circuits. For large circuits, heuristics to find lower and upper bounds of the maximum defect-free I/sub DDQ/ are presented. Uncertainty margins lower than 15% have been found in the circuits experimented on.
Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis.

Chie Onishi, Satomi Mori-Kimachi, Tomohiro Hirade, Mariko Abe, Takeshi Taketani, Junji Suzumiya, Toshitsugu Sugimoto, Seiji Yamaguchi, Reuben Kapur, and Seiji Fukuda Dr. Onishi’s name was misspelled. The correct spelling is Chie Onishi, as shown in the author line. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 47, p. 28356, November 20, 2015 © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.