Miracle-dz/UniFAR-FTUs huggingface dataset:
The Students' Perspectives on Applying Design Thinking for the Design of Mobile Applications

Design Thinking (DT) is relevant for companies committed to developing a more creative and innovative application. DT provides a human-centered view of technological artifact design. Therefore, it is important to learn DT in Computer Science and Software Engineering courses as an analytic and creative process, in order to better prepare students for the software development industry. We conducted an empirical study with 17 postgraduate students in the context of mobile applications design. We used coding procedures from the Grounded Theory method for analyzing the obtained qualitative data. Based on the results, we identified some difficulties that participants experienced in using different DT techniques. The results of this study can help teachers understand the difficulties faced by students in learning DT and, consequently, help them to look for new teaching strategies for their classes. Moreover, these results can contribute to the software industry showing the competitive advantages of using DT in the design of the applications under development, especially in mobile applications.
Blood pressure reduction and renin-angiotensin system inhibition for prevention of congestive heart failure: a meta-analysis.

AIMS It is unclear whether prevention of congestive heart failure (CHF) by drugs that inhibit the renin-angiotensin system (RAS) occurs over and beyond the reduction in blood pressure (BP) achieved by these drugs. METHODS AND RESULTS We conducted a meta-analysis of trials comparing angiotensin-converting enzyme inhibitors (ACEIs), angiotensin-receptor blockers (ARBs), or calcium-channel blockers (CCBs), with diuretics, beta-blockers, or placebo in hypertensive or high-risk subjects without CHF at entry. Both fixed- and random-effect models were used. In trials vs. placebo, the risk of CHF was reduced by 21% with ACEIs (P = 0.007), whereas the effect of ARBs and CCBs was not significant (random-effect models). Thus, CCBs did not increase the risk of CHF. In trials vs. diuretics/beta-blockers, no differences were found between ACEIs and comparators [odds ratio (OR) 1.02; 95% confidence interval (CI) 0.84-1.24], whereas CCBs were associated with an 18% higher risk of CHF (OR 1.18; 95% CI 1.00-1.39; P = 0.048). Therefore, ACEIs were not superior to diuretics/beta-blockers for the prevention of CHF. Because heterogeneity between trials was significant, we investigated potential sources of heterogeneity by meta-regression. The risk of CHF decreased by 24% (P < 0.001) for each 5 mmHg reduction in systolic BP. The risk of CHF was 19% less with ACEIs/ARBs than CCBs (P < 0.001) and 16% less in studies without multiple risk factors required for entry (P = 0.009). CONCLUSION BP reduction is beneficial for the prevention of CHF. Over and beyond BP reduction, the protective effect of ACEIs and ARBs is greater than that of CCBs.
Interaction of ZPR 1 with translation elongation factor-1 alpha in proliferating cells

The zinc finger protein ZPR1 is present in the cytoplasm of quiescent mammalian cells and translocates to the nucleus upon treatment with mitogens, including epidermal growth factor (EGF). Homologues of ZPR1 were identified in yeast and mammals. These ZPR1 proteins bind to eukaryotic translation elongation factor-1 a (eEF-1 a ). Studies of mammalian cells demonstrated that EGF treatment induces the interaction of ZPR1 with eEF-1 a and the redistribution of both proteins to the nucleus. In the yeast Saccharomyces cerevisiae , genetic analysis demonstrated that ZPR1 is an essential gene. Deletion analysis demonstrated that the NH 2 -terminal region of ZPR1 is required for normal growth and that the COOH-terminal region was essential for viability in S . cerevisiae . The yeast ZPR1 protein redistributes from the cytoplasm to the nucleus in response to nutrient stimulation. Disruption of the binding of ZPR1 to eEF-1 a by mutational analysis resulted in an accumulation of cells in the G2/M phase of cell cycle and defective growth. Reconstitution of the ZPR1 interaction with eEF-1 a restored normal growth. We conclude that ZPR1 is essential for cell viability and that its interaction with eEF-1 a contributes to normal cellular proliferation.
Consequences of Error Announcements on Industry Peers: Capital Market Reaction and Financial Reporting Decisions

This paper analyzes the reactions of investors and management to an error announcement within an industry. We investigate capital market reactions as well as changes in the financial reporting decisions for a sample of CDAX®-listed industry peers to error firms in Germany. We find that peers suffer on average negative cumulative abnormal returns of -0.92% within the five day event window. More precisely, we show the contagion effect for the German setting by analyzing industry peers to error firms with negative abnormal returns. This finding can be interpreted as a loss of investors’ confidence in the reliability of financial reporting within the respective industry. As a consequence of the error announcement, all industry peers might have incentives to regain reputation. Therefore, we also examine whether industry peers change the transparency of financial reporting after the event. Our results reveal that industry peers present more informative financial reporting as measured by more timely loss recognition after the error announcements. Nevertheless, we find no evidence for an increase in the preciseness of forecast reporting caused by the event. Supplemental tests reveal no significant increase in auditor turnover after an industry peer’s error announcement, suggesting that industry peers do not penalize their auditors after the stock price decline.
A Murine Model for the Study of Chlamydia trachomatis Genital Infections during Pregnancy

ABSTRACT Pregnant BALB/c mice were inoculated intravaginally on day 5 of gestation with the Chlamydia trachomatis mouse pneumonitis biovar. Animals that received 105, 106, or 107 inclusion-forming units (IFU) of C. trachomatis delivered prematurely on days 15 to 16 of gestation. A focal inflammatory infiltrate was observed in the wall of the uterus on the day 14 of gestation in animals inoculated with 105IFU. In this group of mice, immunohistochemical analysis showed chlamydial inclusions in the endometrium and fetal membranes.
Changes in the composition of sows' milk between days 5 to 26 of lactation

Se han utilizado 10 cerdas Landrace x Large White con el fin de estudiar la evolucion de la composicion de la leche durante la lactacion. Los contenidos de materia seca, proteina bruta y energia bruta obtenidos los dias 5, 12, 19 y 26 de lactacion fueron 195,7, 192,2, 185,4 y 184,1 g/kg-1; 59,3, 55,8, 55,1, y 54,8 g/kg-1 y 1,30, 1,18, 1,16 y 1,17 Mcal kg-1 respectivamente. Las concentraciones de materia seca, proteina bruta y energia bruta no variaron significativamente durante el periodo de lactacion. El contenido en aminoacidos totales (excepto triptofano, prolina y cistina) fue 73,5, 77,6, 82,7 y 81,8 g/100 g de proteina en los dias 5, 12, 19 y 26 de lactacion respectivamente, siendo las concentraciones de lisina, en los dias de control precitados, 5,97, 6,41, 7,05 y 6,81 g/100 g de proteina respectivamente. El contenido de todos los aminoacidos estudiados, salvo algunas escepciones (metionina, treonina, histidina y glicina), variaron significativamente (P<0,05) durante el periodo de lactacion. La variacion encontrada, a lo largo de la lactacion, de la concentracion de algunos aminoacidos (lisina, leucina, valina y acido glutamico) puede ser atribuida a la variacion de la relacion entre la caseina y las proteinas del suero durante dicho periodo.
PENGARUH LARGE BOOK-TAX DIFFERENCES TERHADAP PERSISTENSI LABA, AKRUAL DAN ARUS KAS PADA PERUSAHAAN MANUFAKTUR DI BEI

Quality earnings are earnings which may reflect the continuation of future earnings, which is determined by the components of accruals and cash flows. Book-tax differences may represent the management discretion in the accrual process to assess the quality of earnings. Persistence of earnings is one component of the predictive value of earnings and also the element of relevance that some information in the book-tax differences may affect the persistence of earnings. This study aims to examine the effect of large book-tax differences on the persistence of earnings, accruals and cash flows compared to firms with small book-tax differences and earnings persistence effect on investor expectations especially for the persistence of accruals on each sub-sample of book-tax differences. Object of study is a manufacturing company listed on the Stock Exchange in 2008-2009 with a sample of 37 manufacturing companies selected by purposive sampling technique. The results showed firms with large negative book-tax differences have persistence of the accrual component of earnings that are not much different from the firms with small book-tax differences and not proven that the stock price could reflect the persistence of earnings, accruals and cash flows but investors tend to be pessimistic about the current earnings in relation to future earnings in other words, earnings is considered to have low persistence for all sub-sample of book-tax differences.
HLA-Associated Hemorrhagic Fever with Renal Syndrome Disease Progression in Slovenian Patients

ABSTRACT Major histocompatibility complex (MHC) class I and class II genes regulate the balance between appropriate aggressive responses and invading pathogens while minimizing the destruction of host tissue. Several studies have shown that in hemorrhagic fever with renal syndrome (HFRS) patients, the disease outcome is determined by a complex interaction between the virus and immunopathologic and human genetic factors. In Slovenia, the severity of the disease caused by Puumala virus (PUUV) is significantly lower than that of HFRS due to Dobrava virus (DOBV). We have determined 23 different HLA-B and 12 different HLA-DRB1 types in Slovenian HFRS patients. Comparison of HLA frequencies between healthy individuals and HFRS patients showed no strong association with the susceptibility for hantaviral infection. Significant associations were recognized when the patient group was separated according to the virus responsible for the infection. DOBV-infected patients have a significantly higher frequency of HLA-B*35 than PUUV-infected patients. For HLA class II genes, the biggest difference between the PUUV- and DOBV-infected groups of patients was in HLA-DRB1*13, where this phenotype was more frequent in PUUV-infected patients, especially in the severe form of the disease. HLA-B*07 could play a protective role in PUUV-caused HFRS in the Slovenian population. Our study shows diverse associations of HLA molecules with DOBV- and PUUV-induced HFRS, and therefore, we presume that different hantaviruses are presented differently through the same HLA molecules and that this might lead to either a more severe or a milder form of the disease. In line with this idea, we have noticed that HLA-B*35 might be a genetic risk factor for DOBV infection in the Slovenian population.
Software quality : increasing value in software and systems development : 5th International Conference, SWQD 2013, Vienna, Austria, January 15-17, 2013 proceedings

Keynotes. - Software Quality: From Requirements to Architecture. - The Consortium for IT Software Quality (CISQ). - Risk Management. - Experiences and Challenges of Introducing Risk-Based Testing in an Industrial Project. - Project Progress and Risk Monitoring in Automation Systems Engineering. - Software and Systems Testing. - WebMate: Generating Test Cases for Web 2.0. - Testing Web Services in the Cloud. - Model-Based Strategies for Reducing the Complexity of Statistically Generated Test Suites. - Hazard Analysis for Technical Systems. - Test Processes. - Using Defect Taxonomies to Improve the Maturity of the System Test Process: Results from an Industrial Case Study. - Model-Based Development. - A Transformation of Business Process Models into Software-Executable Models Using MDA. - Aligning Domain-Related Models for Creating Context for Software Product Design. - Process Improvement and Measurement. - Mapping CMMI and RUP Process Frameworks for the Context of Elaborating Software Project Proposals. - Development and Evaluation of Systems Engineering Strategies: An Assessment-Based Approach. - Improving Completeness of Measurement Systems for Monitoring Software Development Workflows. - Exploiting Natural Language Definitions and (Legacy) Data for Facilitating Agreement Processes.
Genetic fuzzy system for intrusion detection: Analysis of improving of multiclass classification accuracy using KDDCup-99 imbalance dataset

Genetic fuzzy systems (GFSs) hybridize the approximate reasoning method of fuzzy systems with the learning capability of evolutionary algorithms. The objective of this paper is to focus on an important class of problems in the field of network intrusion detection, namely, the class imbalance problem, one of the problems strongly tied with the classification of the database of intrusion detection. In this work we have used a fuzzy association rule based classification method, to obtain an accurate and compact fuzzy rule-based classifier with a low computational cost. We have proposed the use of a novel fitness function to deal with the problem of imbalance dataset in the genetic post processing phase for rule selection and parameter tuning. The efficiency of the proposed system has been shown through a complete detailed experimental comparative study with well-known classifiers reported in the IDS literature. Experiments were performed with KDD Cup 99 intrusion detection benchmark data set as an example of a network traffic data.
Post-Louvre Intervention: Did Target Zones Stabilize the Dollar?

At their Louvre meeting in February 1987, the Group of Seven (G7) countries agreed to stabilize dollar exchange rates. Over the next two years, central banks frequently bought and sold dollars in a manner broadly consistent with attempting to maintain target zones, and dollar exchange rates appeared more stable than they previously had been.
An inverse correlation between estimated tuberculosis notification rates and asthma symptoms

Background: A recent ecological analysis demonstrated a strong inverse relationship between tuberculosis notification rates and the prevalence of asthma symptoms in 13–14‐year‐old children as obtained from the International Study of Asthma and Allergies in Childhood (ISAAC). However, the analysis was confined to the 23 countries in which the tuberculosis notification rates were considered to be of sufficient validity.
Effect of Different Ionophore Treatments on Some Rumen Metabolic Measures of Steers

Twelve 380 kg beef steers were fed a 90% concentrate, cracked cornbased diet at 85% of ad libitum. Steers were divided into three daily ionophore treatment groups, Monensin Tylan (MT), Lasalosid (L) or rotation of MT and L (MTL). Each daily dosage of Monensin and Tylan was 2.7 and 1.1 mg per BW, respectively. Lasolosid additions were given at 3 mg per BW' daily. Ruminal samplings were taken on d 0, 2, 5, 16 and 45 after beginning ionophore treatments. A conventional digestibility trial was conducted with nine steers (three per treatment) at day 34 of feeding the ionophore and lasted for six days. Digestible energy (83.7%), urinary losses (3.3%) of total feed energy and the ratio of ME/DE (90%) did not differ across treatments. Methane losses were from 17 to 37% less on d 2 and 5 for MT and MTL treatments but increased quadratically (PO.05) on d 16 and 45 so that production exceeded d 0 levels. Treatment L did not affect methane production. Acetate to propionate and to butyrate ratios were reduced (PO.05) by MT and MTL with no effect for L addition. These data suggest that methane suppression does not persist beyond two weeks of ionophore treatment and a daily rotation of ionophores had no digestive or metabolic advantage over feeding MT daily. Further research is recommended to investigate the proper dose, componation and duration of ionophores supplementation in order to achieve the best results out of the fattening operations.
Cascading k-means with Ensemble Learning: Enhanced Categorization of Diabetic Data

Abstract. This paper illustrates the applications of various ensemble methods for enhanced classification accuracy. The case in point is the Pima Indian Diabetic Dataset (PIDD). The computational model comprises of two stages. In the first stage, k-means clustering is employed to identify and eliminate wrongly classified instances. In the second stage, a fine tuning in the classification was effected. To do this, ensemble methods such as AdaBoost, bagging, dagging, stacking, decorate, rotation forest, random subspace, MultiBoost and grading were invoked along with five chosen base classifiers, namely support vector machine (SVM), radial basis function network (RBF), decision tree J48, naïve Bayes and Bayesian network. The k-fold cross validation technique is adopted. Computational experiments with the proposed method showed an improvement of 16.14% to 22.49% in the classification accuracy compared to literature survey. Among the ensemble methods tried, MultiBoost ensemble with SVM classifier and grading ensemble with naïve Bayes showed the best performance followed by MultiBoost, stacking and grading ensemble with Bayesian classifier, rotation forest ensemble with RBF and grading and rotation forest ensemble with J48. This investigation conclusively proves the significance of cascading k-means clustering with ensemble methods in the enhanced accuracy in categorization of diabetic dataset.
Differential overvoltages and common-mode currents in PWM motor drives: The influence of the cable arrangement on their characteristics

Transient overvoltages at motor terminals and high-frequency common-mode currents in PWM drive systems have been extensively investigated in the last fifteen years. Nevertheless, some issues concerning such quantities still remain unclear. That is the case of the converter-to-motor cabling influence on the intensity of these high-frequency voltages and currents. Filters of different types have been traditionally used to mitigate these undesired phenomena. However, due to their cost, volume and losses, they can't be considered the ultimate solution of the problem. In this paper, typical industrial cable arrangements will be characterized in terms of the generated transient overvoltages and common-mode currents. It will be shown that variations in the range of 10 to 40 % in the peak values of these quantitites can take place due to different cable disposition. Thus, it can be concluded that special care in the cable installation can lead to significant reduction in these undesired phenomena, which in turn downsizes the required filter.
Catalytic Pyrolysis of Waste Tyre Rubber into Hydrocarbons Via Base Catalysts

The waste tyres represent a source of energy and valuable hydrocarbon products. Waste tyres were pyrolysed catalytically in a batch reactor under atmospheric pressure. The effects of basic catalysts (MgO and CaCO3) were studied on the pyrolysis products. The distribution ratio of gas, liquid and char with MgO and CaCO3 were 24.4:39.8:35.8 wt % and 32.5:32.2:35.2 wt % respectively at 350 ° C for 2hr catalytic pyrolysis. The physical and chemical properties of the pyrolzed products obtained were characterized. Both catalysts produced 25 % wt of aliphatic hydrocarbons but with the use of magnesium oxide the aromatic hydrocarbons increased (55 %) and polar hydrocarbons decreased (20 %) as compared to calcium carbonate catalyst (50 % aromatic and 25 % polar hydrocarbons). As far as the distillation data and fuel tests are concerned, the oil fractions with both catalysts fulfill the present specifications of diesel fuel commercial products.
The Role of Corporate Governance and Information Asymmetry in Private Placement in Australia

In a private sale of equity, the issuing firm sells a block of securities to an individual or a small group of investors at a discounted price. Non-participating shareholders suffer from ownership dilution and are also deprived of the discount. We provide the first evidence on whether and how corporate governance can protect non-participating shareholders’ interests in private placements. Based on a sample of 329 private placements issued by the top 250 Australian listed firms between 2002 and 2009, we find firms with a higher governance index, a larger proportion of independent directors, and a larger board are more likely to issue private placements with a share purchase plan (SPP), which protects non-participating shareholders from ownership dilution. However corporate governance has no impact on private placement discounts. There is also evidence that private placement discounts compensate investors for information asymmetry. Our findings are robust to corrections for endogeneity and self-selection bias.
Leverage, Volatile Future Earnings Growth and Expected Stock Returns

We provide theory and evidence to complement Choi's [RFS, 2013] important new insights on the returns to equity in 'value' firms. We show that higher future earnings growth ameliorates the value-reducing effect of leverage and, because the market for earnings is incomplete, reduces the earnings-risk sensitivity of the default option. Ceteris paribus, a levered firm with low (high) earnings growth is more sensitive to the first (second) of these effects thus generating higher (lower) expected returns. We demonstrate this by modelling equity as an Asian-style call option on net earnings and find significant empirical support for our hypotheses.