Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of thrombocytopenia and flu-like symptoms in dengue patients with herbal water of Euphorbia hirta.

BACKGROUND Incidence of dengue increased 30 fold between 1960 and 2010. This increase is believed to be due to a combination of urbanisation, population growth, increased international travel, and global warming. We tried to find out the effect of herbal water of Tawa-tawa, also called Euphorbia hirta, on the flu like symptoms and blood parameters especially on thrombocytopenia. METHODS Total 125 patients with confirmed dengue fever admitted in medical ward of Sir Ganga Ram Hospital Lahore were included in this experimental study. Duration of study was 3 months. Patients were divided into 2 groups, i.e., group A (ages between 30 to 55 years) and group B (ages between 14 to 25 years). A blood sample was obtained on the day of enrolment and after 24 hours of using Tawa-tawa. The variables used were platelet count, haematocrit (HCT), WBC count, serum AST, ALT, IgM/IgG. RESULTS In men, platelet count was < 25,000 and in women, it was > 50,000. Haematocrit were >40% in men and 30-40% in women. TLC in a range of 4,000-11,000/mm3 was observed in both males and females. IgM 'haemagglutination' antibody titres (> 1:160) was observed in 71.3% females and 50% males. Serum AST was > 40 IU/L in 38% females and 36% males. Serum ALT was > 40 IU/L in 9.5% females and 12% males. In both group A and B platelet count and TLC were increased nonsignificantly after herbal water of Euphorbia hirta (E. Hirta). Haematocrit value decreased nonsignificantly after using the herbal water. Over 70% of patients showed moderate increase in their platelet count. However leucopoenia improved significantly after the use of aqueous extract of E. hirta. A marked recovery in fever and flu like symptoms was observed. CONCLUSION In over 70% patients there was improvement in platelet count, TLC, fever, and flue-like symptoms.
The regulation of prostaglandin output from term intact fetal membranes byanti‐inflammatory cytokines

Prostaglandins are some of the main mediators which control parturition, and their production by intrauterine tissues can be up‐regulated by pro‐inflammatory cytokines. Anti‐inflammatory cytokines may oppose these effects, and in this study we have investigated how two such cytokines affected fetal membrane function. Interleukin‐10 (IL‐10) inhibited the output of prostaglandin E2 (PGE2) from intact fetal membranes under basal and lipopolysaccharide (LPS)‐stimulated conditions, and there was a parallel decrease in the expression of mRNA for COX‐2. IL‐10 also inhibited the production of interleukin‐1β (IL‐1β) and the expression of mRNA for IL‐1β, indicating that this cytokine has a broad anti‐inflammatory effect. Transforming growth factor‐β1 (TGF‐β1), which is generally considered to be anti‐inflammatory had opposite effects on PGE2 production, in that it increased the output of PGE2 for up to 8 hr. TGF‐β1 increased levels of type‐2 cyclo‐oxygenase (COX‐2) and cytosolic phospholipase A2 (cPLA2) protein, and also activated the cPLA2 enzyme present; the profile of effects is similar to that of the pro‐inflammatory cytokine IL‐1β, and was not expected. Combinations of TGF‐β1 with IL‐1β also increased PGE2 output and caused appropriate changes in prostaglandin pathway enzymes, whereas TGF‐β1 and IL‐1α had more limited effects. Further studies are needed to establish the physiological significance of these findings, but TGF‐β1 does not seem to act as an inhibitory cytokine in intact fetal membranes at term.
Molecular dynamics of drop spreading on a solid surface.

We have studied the spreading of liquid drops on a solid surface by molecular-dynamics simulations of Lennard-Jones systems of liquid, vapor, and solid. As the attraction between liquid and solid increases we observe a smooth transition from partial wetting to terraced wetting, with distinct molecular layers spreading with different velocities. In the terraced case the layers are ordered but not solid, with substantial molecular diffusion both within and between layers, and a growth rate that disagrees with experiments with nonvolatile liquids as well as recent calculations
Analysis of Spectrum Efficiency and Energy Efficiency of Heterogeneous Wireless Networks With Intra-/Inter-RAT Offloading

Offloading the users from capacity-strained macrocells in a cellular network to small cells is an effective strategy to support the increasing mobile data traffic, but a key challenge is how to simultaneously achieve high spectrum efficiency (SE) and energy efficiency (EE) in the heterogeneous radio access technology (RAT) environment. This paper develops an analytical framework for studying the performance of a two-RAT heterogeneous network (HetNet) comprising cellular and wireless local area network (WLAN) RATs. Using the developed framework, the feasibility of enhancing the SE and EE via the implementation of biased intra- and inter-RAT offloading techniques is investigated. Findings from the analysis reveal that the performance gain for SE and EE is strongly dependent on the load level and the base station (BS) power consumption attributes. A multiobjective optimization problem that maximizes the SE and EE subject to quality-of-service (QoS) constraints is formulated and solved to give the Pareto-optimal operational regime specified in terms of the small-cell BS densities and biasing factors. The novelty of this paper is the quantification of the SE-EE tradeoff as an opportunity cost measure, which is defined by the constrained Pareto-optimal regime. The insight gained from analyzing the opportunity cost is used to formulate a strategy that exploits the varying load conditions to achieve a good balance in the SE-EE tradeoff. Numerical results show that, although the potential to reduce the performance gap between SE and EE is marginal under low and high load conditions, it is feasible to significantly improve the network performance by balancing the SE-EE tradeoff during the medium load condition, as well as satisfy the users' QoS requirements by optimally adapting the small-cell BS density and offloading biasing factors.
Omalizumab in pediatric cold contact urticaria: warm blanket for a cold bath?

1. McWilliam V, Koplin J, Lodge C, Tang M, Dharmage S, Allen K. The prevalence of tree nut allergy: a systematic review. Curr Allergy Asthma Rep 2015: 15: 1–3. 2. Cummings AJ, Knibb RC, King RM, Lucas JS. The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review. Allergy 2010: 65: 933–45. 3. Eller EU, Bindslev-Jensen C. Clinical value of component-resolved diagnostics in peanut-allergic patients. Allergy 2013: 68: 190–4. 4. Beyer K, Grabenhenrich L, H€artl M, et al. Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children. Allergy 2015: 70: 90–8. 5. Savvatianos S, Konstantinopoulos AP, Borg a A, et al. Sensitization to cashew nut 2S albumin,Anao3, ishighlypredictiveofcashew and pistachio allergy in Greek children. J Allergy Clin Immunol 2015: 136: 192–4. 6. CiprandiG,PistorioA,SilvestriM,RossiGA, Tosca MA.Walnut anaphylaxis: the usefulness of molecular-based allergy diagnostics. Immunol Lett 2014: 161: 138–9. 7. Theofficial listofallergens.WHO/IUIS AllergenNomenclatureSub-Committee. http://www.allergen. org/AccessedJune2016. 8. Sordet C, Culerrier R, Granier C, et al. Expression of Jug r 1, the 2S albumin allergen from walnut (Juglans regia), as a correctly folded and functional recombinant protein. Peptides 2009: 30: 1213–21. 9. Scala E, Till SJ, Asero R, et al. Lipid transfer protein sensitization: reactivity profiles and clinical risk assessment in an Italian cohort. Allergy 2015: 70: 933–43. 10. Maloney JM, Rudengren M, Ahlstedt S, et al. The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. J Allergy Clin Immunol 2008: 122: 145–51.
Semantic mediation between ontologies

Mediators describe elements that handle interoperability problems between different web services. A particular type of mediators is the data mediator, which is used to solve the terminological mismatches between ontologies. Ontology is a specification of conceptualisation which represents a key element of Semantic Web Services (SWS). Formally, it specifies the terminology used to describe a SWS functionality and behaviour. When the web services interact with each other and there are some requests needed from these services, the instance data must be translated from terms of a service into terms of the other service which is called instance transformation. This paper presents a design and an implementation of a mediator, to handle interoperability between two different ontologies. Different types of transformation services are presented and several transformation operations are explained in order to enable the mapping process. A new tool is proposed which has a facility to build ontologies with the ability for creating mediators. The proposed mediator can exploit many types of transformation services. The advantages of that mediator over the previous ones are explained and its implementation is investigated.
Accessibility to the public environment as perceived by teenagers with functional limitations in a south Swedish town centre

Purpose : Owing to physical inaccessibility persons with mobility restrictions and other functional limitations often face problems in public environments, leading to restrictions in activity and participation. To investigate general accessibility and perceived problems of accessibility to the public environment in a town centre, as well as visiting preferences to public facilities, among teenagers with functional limitations. Methods : An interview questionnaire specific to a south Swedish town was constructed and used with 33 Swedish teenagers with functional limitations. Results : To a varying degree, all 33 teenagers commented on accessibility problems, e.g. concerning uneven surface material outdoors, steps at entrances, heavy doors and restricted space indoors. The results also indicated that teenagers with functional limitations to a high extent want to visit the same environments as other teenagers, but that it is often impossible owing to accessibility problems. Furthermore, because of accessibility problems, many of the teenagers were dependent on personal assistance. Conclusion : Inaccessibility results in dependence, which might affect personal development negatively, and much effort are required in order to ensure activity and societal participation. Efficient priorities in public environment accessibility matters and discussions with the actors involved require valid and reliable data on local accessibility problems.
The Impact of Log Moisture Content on Chip Size Distribution When Processing Eucalyptus Pulpwood

Chip moisture content and especially its uniformity impact kraft pulping. However, the effect of pulp log moisture content on chip quality during chip production is not well known. Chip size distribution is important in kraft pulping as it impacts chemical use, pulp quality and recovery. This study investigated the influence of two pulp log drying periods (1 and 2 weeks) on chip moisture content and chip size distribution when chipping eucalypt pulp logs. In addition, the effect of three log classes (base, middle and top logs) on chip moisture content and chip size distribution were also analysed. Within the respective log classes, moisture content of chips produced from logs dried for 2 weeks was 5.5% to 13.2% lower than moisture content of chips produced from logs dried for 1 week. Chip moisture content also decreased with decreasing log size for both log drying periods. One week dried logs produced chips with 1.0% less over-thick chips than 2 week dried logs (1.5% versus 2.5%). One week dried logs also produced chips with 4.2% to 7.2% less accepts than chips produced from 2 week dried logs within respective log classes. Across both drying periods, over-thick chip production increased with decreasing log size, while the amount of accepts produced decreased with decreasing log size. Logs dried for 2 weeks produced chips with significantly less under-sized chips than logs dried for 1 week. Two week dried logs produced chips with 4.4% to 7.7% less pins and 0.7% to 1.0% less fines than 1 week dried logs within respective log classes. For both log drying periods, the amount of under-sized chips produced increased with decreasing log size.
Monoclonal antibodies against the fusion protein are protective in necrotizing mumps meningoencephalitis

A monoclonal antibody against the fusion (F) protein of mumps virus was found to confer marked protection in mumps virus-induced encephalitis. Almost total prevention of extensive brain necrosis was found. This study indicates that the virus F protein is directly involved in the pathogenesis of brain necrosis.
The treatment of helicobacter pylori infection and its sequelae with emphasis on nitroimidazole resistance

In this thesis two different aspects of the treament of Helicobacter pylori (H. pylori) infection are described. The first part (chapters 2-8) explores the epidemiology, mechanism, and clinical significance of nitroimidazole resistance as well as the problems encountered in susceptibility testing for nitroimidazoles. ln the second part (chapters 9 -11) three studies concerning the short and long term sequelae of the treatment of this infection are described. Zie: Summary
Global chaos synchronization of new chaotic system using linear active control

Chaos synchronization is a procedure where one chaotic oscillator is forced to adjust the properties of another chaotic oscillator for all future states. This research paper studies and investigates the global chaos synchronization problem of two identical chaotic systems and two non-identical chaotic systems using the linear active control technique. Based on the Lyapunov stability theory and using the linear active control technique, the stabilizing controllers are designed for asymptotically global stability of the closed-loop system for both identical and non-identical synchronization. Numerical simulations and graphs are imparted to justify the efficiency and effectiveness of the proposed scheme. All simulations have been done by using mathematica 9. © 2014 Wiley Periodicals, Inc. Complexity 21: 379-386, 2015
Altered right anterior insular connectivity and loss of associated functions in adolescent chronic fatigue syndrome

Impairments in cognition, pain intolerance, and physical inactivity characterize adolescent chronic fatigue syndrome (CFS), yet little is known about its neurobiology. The right dorsal anterior insular (dAI) connectivity of the salience network provides a motivational context to stimuli. In this study, we examined regional functional connectivity (FC) patterns of the right dAI in adolescent CFS patients and healthy participants. Eighteen adolescent patients with CFS and 18 aged-matched healthy adolescent control participants underwent resting-state functional magnetic resonance imaging. The right dAI region of interest was examined in a seed-to-voxel resting-state FC analysis using SPM and CONN toolbox. Relative to healthy adolescents, CFS patients demonstrated reduced FC of the right dAI to the right posterior parietal cortex (PPC) node of the central executive network. The decreased FC of the right dAI–PPC might indicate impaired cognitive control development in adolescent CFS. Immature FC of the right dAI–PPC in patients also lacked associations with three known functional domains: cognition, pain and physical activity, which were observed in the healthy group. These results suggest a distinct biological signature of adolescent CFS and might represent a fundamental role of the dAI in motivated behavior.
Driven discrete time quantum walks

We introduce the driven discrete time quantum walk (QW), where walkers are added during the walk instead of only at the beginning. This leads to interference in walker number and very different dynamics when compared to the original QW. These dynamics have two regimes, which we illustrate using the one-dimensional line. Then, we explore a search application which has certain advantages over current search protocols, namely that it does not require a complicated initial state nor a specific measurement time to observe the marked state. Finally, we describe a potential experimental implementation using existing technology.
Impact of Physico-Chemical Factors of Contaminated Foci on the Survival of Geohelminths in Abua Communities, Niger Delta Nigeria

Physio-chemical analysis of 200 soil samples collected from contaminated foci was investigated in six communities of Abua, Niger Delta Nigeria. The Jackson’s method was used in the chemical analysis of contaminated soils while Cobb’s decanting and sieving method was used in the extraction of geohelminths. The data showed that temperature, pH, Calcium (Ca 2+ ), magnesium (mg 2+ ), potassium (k + ) ions and electrical conductivity had much effect on the survival of eggs and larval development of geohelminths. It was also observed that the nature of the soil in the study communities was clay-loam and sandy-loamy. The continuous deposition of human faeces in these contaminated foci should be discouraged. This can be achieved by the construction of toilet facilities of whatever description in the study area by the government. @JASEM J. Appl. Sci. Environ. Manage . December, 2010, Vol. 14 (4) 117 - 121
Extended red light harvesting in a poly(3-hexylthiophene)/iron disulfide nanocrystal hybrid solar cell

A polymer solar cell based on poly(3-hexylthiophene) (P3HT)/iron disulfide (FeS2) nanocrystal (NC) hybrid is presented. The FeS2 NCs of 10 nm in diameter were homogeneously blended with P3HT to form an active layer of a solar cell. An extended red light harvesting up to 900 nm resulting from the NCs in the device has been demonstrated, compared to a typical absorption edge of 650 nm of a pristine P3HT. The environmentally friendly and low-cost FeS2 NCs can be used as a promising candidate for an acceptor in the polymer solar cell device application with an enhanced photovoltaic response in the extended red light region.
Emotion Feelings Stem from Evolution and Neurobiological Development, Not From Conceptual Acts: Corrections for Barrett et al. (2007)

Contrary to the arguments of Barrett et al. (2007) in critiquing Izard (2007), emotion feelings (the key component of human emotions) stem from evolution and neurobiological development, not from conceptual acts. Barrett et al. made several other erroneous and seriously misleading criticisms of Izard (2007), and they had little to say about the final two thirds of that article—an explication of emotion schemas and a new paradigm.
Accelerating Decision Tree Based Traffic Classification on FPGA and Multicore Platforms

Machine learning (ML) algorithms have been shown to be effective in classifying a broad range of applications in the Internet traffic. In this paper, we propose algorithms and architectures to realize online traffic classification using flow level features. First, we develop a traffic classifier based on C4.5 decision tree algorithm and Entropy-MDL (Minimum Description Length) discretization algorithm. It achieves an overall accuracy of 97.92 percent for classifying eight major applications. Next we propose approaches to accelerate the classifier on FPGA (Field Programmable Gate Array) and multicore platforms. We optimize the original classifier by merging it with discretization. Our implementation of this optimized decision tree achieves 7500+ Million Classifications Per Second (MCPS) on a state-of-the-art FPGA platform and 75-150 MCPS on two state-of-the-art multicore platforms. We also propose a divide and conquer approach to handle imbalanced decision trees. Our implementation of the divide-and-conquer approach achieves 10,000+ MCPS on a state-of-the-art FPGA platform and 130-340 MCPS on two state-of-the-art multicore platforms. We conduct extensive experiments on both platforms for various application scenarios to compare the two approaches.
Pten Null Prostate Epithelium Promotes Localized Myeloid-Derived Suppressor Cell Expansion and Immune Suppression during Tumor Initiation and Progression

ABSTRACT Chronic inflammation is known to be associated with prostate cancer development, but how epithelium-associated cancer-initiating events cross talk to inflammatory cells during prostate cancer initiation and progression is largely unknown. Using the Pten null murine prostate cancer model, we show an expansion of Gr-1+ CD11b+ myeloid-derived suppressor cells (MDSCs) occurring intraprostatically immediately following epithelium-specific Pten deletion without expansion in hematopoietic tissues. This MDSC expansion is accompanied by sustained immune suppression. Prostatic Gr-1+ CD11b+ cells, but not those isolated from the spleen of the same tumor-bearing mice, suppress T cell proliferation and express high levels of Arginase 1 and iNOS. Mechanistically, the loss of PTEN in the epithelium leads to a significant upregulation of genes within the inflammatory response and cytokine-cytokine receptor interaction pathways, including Csf1 and Il1b, two genes known to induce MDSC expansion and immunosuppressive activities. Treatment of Pten null mice with the selective CSF-1 receptor inhibitor GW2580 decreases MDSC infiltration and relieves the associated immunosuppressive phenotype. Our study indicates that epithelium-associated tumor-initiating events trigger the secretion of inflammatory cytokines and promote localized MDSC expansion and immune suppression, thereby promoting tumor progression.
Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs.

BACKGROUND People who take analgesic drugs frequently may be at increased risk of end-stage renal disease (ESRD), but the extent of this risk remains unclear. METHODS We studied 716 patients treated for ESRD and 361 control subjects of similar age from Maryland, Virginia, West Virginia, and Washington, D.C. The study participants were interviewed by telephone about their past use of medications containing acetaminophen, aspirin, and other nonsteroidal antiinflammatory drugs (NSAIDs). For each analgesic drug, the average use (in pills per year) and the cumulative intake (in pills) were examined for any association with ESRD. RESULTS Heavier acetaminophen use was associated with an increased risk of ESRD in a dose-dependent fashion. When persons who took an average of 0 to 104 pills per year were used for reference, the odds ratio of ESRD was 1.4 (95 percent confidence interval, 0.8 to 2.4) for those who took 105 to 365 pills per year and 2.1 (95 percent confidence interval, 1.1 to 3.7) for those who took 366 or more pills per year, after adjustment for race, sex, age, and intake of other analgesic drugs. When persons who had taken fewer than 1000 pills containing acetaminophen in their lifetime were used for reference, the odds ratio was 2.0 (95 percent confidence interval, 1.3 to 3.2) for those who had taken 1000 to 4999 pills and 2.4 (95 percent confidence interval, 1.2 to 4.8) for those who had taken 5000 or more pills. Approximately 8 to 10 percent of the overall incidence of ESRD was attributable to acetaminophen use. A cumulative dose of 5000 or more pills containing NSAIDs was also associated with an increased odds of ESRD (odds ratio, 8.8), but the use of aspirin was not. CONCLUSIONS People who often take acetaminophen or NSAIDs have an increased risk of ESRD, but not those who often take aspirin.