Miracle-dz/UniFAR-FTUs huggingface dataset:
Solid-pseudopapillary carcinoma: a case study and literature review

Solid-pseudopapillary tumour (SPT) is a rare exocrine tumour of the pancreas and is considered to have low malignant potential. Few morphological criteria are used to predict malignant behaviour such as equivocal perineural invasion, angioinvasion and invasion to surrounding tissue, and should be designated as solid-pseudopapillary carcinoma (SPC). We report a case of SPC. Clinical and radiological findings are typical for SPT with no metastatic disease. There is no tumour recurrence after 4 months postresection. Clinical history and radiological findings were retrieved from the patient's record sheet and Viarad system. H&E staining and few immunoproxidase staining were reviewed by several pathologists. The histological findings are typical for SPT, with additional perineural invasion. There is no angioinvasion or capsular invasion identified. This is our first experience in diagnosing and managing SPC. We look forward to seeing the patient's disease status during her next routine follow-up. We expect good disease-free survival and very low risk of tumour recurrence, in view of only one risk factor (perineural invasion) and uninvolved surgical margins by the tumour.
On worst-case to average-case reductions for NP problems

We show that if an NP-complete problem has a non-adaptive self-corrector with respect to a distribution that can be sampled then coNP is contained in AM/poly and the polynomial hierarchy collapses to the third level. Feigenbaum and Fortnow show the same conclusion under the stronger assumption that an NP-complete problem has a non-adaptive random self-reduction. Our result shows it is impossible (using non-adaptive reductions) to base the average-case hardness of a problem in NP or the security of a one-way function on the worst-case complexity of an NP-complete problem (unless the polynomial hierarchy collapses).
Regional blood flow and hemodynamics in the rabbit with adriamycin cardiomyopathy: effects of isosorbide dinitrate, dobutamine and captopril.

We have studied the effects of captopril, nitrates and dobutamine on hemodynamics and regional blood flow in the conscious rabbit with adriamycin cardiomyopathy. Rabbits were injected twice weekly with adriamycin (1 mg.kg-1 bw.) for 8 weeks and subsequently maintained for 2 weeks without adriamycin in order to allow recovery from any noncardiac effects. Doses of drug for investigation (captopril, 300 micrograms.kg-1.min-1; isosorbide dinitrate, 10 micrograms.kg-1.min-1; and dobutamine, 10.9 micrograms.kg-1.min-1) were chosen in anticipation of a 20% increase of cardiac output in animals with heart failure. In animals with heart failure myocardial blood flow was increased by dobutamine and to a lesser extent by captopril. Renal blood flow was increased only by captopril and nitrates. Cerebral blood flow was reduced by captopril in control animals but unaltered in animals with heart failure. The observed alterations of blood flow were similar to those known to occur in humans and indicate that this is a useful model of heart failure for the evaluation of new drugs.
Clinically relevant effectiveness of focused extracorporeal shock wave therapy in the treatment of chronic plantar fasciitis: a randomized, controlled multicenter study.

BACKGROUND The effectiveness of extracorporeal shock wave therapy in the treatment of plantar fasciitis is controversial. The objective of the present study was to test whether focused extracorporeal shock wave therapy is effective in relieving chronic heel pain diagnosed as plantar fasciitis. METHODS Two hundred and fifty subjects were enrolled in a prospective, multicenter, double-blind, randomized, and placebo-controlled U.S. Food and Drug Administration trial. Subjects were randomized to focused extracorporeal shock wave therapy (0.25 mJ/mm(2)) or placebo intervention, with three sessions of 2000 impulses in weekly intervals. Primary outcomes were both the percentage change of heel pain on the visual analog scale composite score (pain during first steps in the morning, pain with daily activities, and pain with a force meter) and the Roles and Maudsley score at twelve weeks after the last intervention compared with the scores at baseline. RESULTS Two hundred and forty-six patients (98.4%) were available for intention-to-treat analysis at the twelve-week follow-up. With regard to the first primary end point, the visual analog scale composite score, there was a significant difference (p = 0.0027, one-sided) in the reduction of heel pain in the extracorporeal shock wave therapy group (69.2%) compared with the placebo therapy group (34.5%). Extracorporeal shock wave therapy was also significantly superior to the placebo therapy for the Roles and Maudsley score (p = 0.0006, one-sided). Temporary pain and swelling during and after treatment were the only device-related adverse events observed. CONCLUSIONS The results of the present study provide proof of the clinically relevant effect size of focused extracorporeal shock wave therapy without local anesthesia in the treatment of recalcitrant plantar fasciitis, with success rates between 50% and 65%. LEVEL OF EVIDENCE Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
The luminosity function of the NoSOCS galaxy cluster sample

We present the analysis of the luminosity function of a large sample of galaxy clusters from the Northern Sky Optical Cluster Survey, using latest data from the Sloan Digital Sky Survey. Our global luminosity function (down to M_r ≾ -16) does not show the presence of an 'upturn' at faint magnitudes, while we do observe a strong dependence of its shape on both the richness and the clustercentric radius, with a brightening of M^* and an increase in the dwarf-to-giant galaxy ratio with the richness, indicating that more massive systems are more efficient in creating/retaining a population of dwarf satellites. This is observed within both physical (0.5R_(200)) and fixed (0.5 Mpc) apertures, suggesting that the trend is either due to a global effect, operating at all scales, or due to a local one but operating on even smaller scales. We further observe a decrease in the relative number of dwarf galaxies towards the cluster centre; this is most probably due to tidal collisions or the collisional disruption of the dwarfs since merging processes are inhibited by the high velocity dispersions in cluster cores and, furthermore, we do not observe a strong dependence of the bright end on the environment. We find an indication that the dwarf-to-giant ratio decreases with increasing redshift, within 0.07 ≤z < 0.2. We also measure a trend for the stronger suppression of faint galaxies (below M^*+ 2) with increasing redshift in poor systems, with respect to more massive ones, indicating that the evolutionary stage of less-massive galaxies depends more critically on the environment. Finally, we point out that the luminosity function is far from universal; hence, the uncertainties introduced by the different methods used to build a composite function may partially explain the variety of faint-end slopes reported in the literature, as well as, in some cases, the presence of a faint-end upturn.
INDUSTRIAL FLUOROSIS IN DOMESTIC GOATS ( CAPRA HIRCUS ) , RAJASTHAN , INDIA

Chronic industrial fluoride (F) toxicosis in the forms of dental, skeletal, and nonskeletal fluorosis was observed in domestic goats (Capra hircus) inhabiting the industrial area near Umarda village located 8–12 km south of Udaipur city in southern Rajasthan (India) where superphosphate fertilizer plants are functioning and releasing F fumes or gases into the surrounding environment. Out of 108 goats (≥3-year-old), 9 (8.33%) exhibited mild to moderate pathognomonic signs of osteodental fluorosis in the form of lightto deep-brownish staining and excessive abrasion of incisor teeth, intermittent lameness, swollen joints, debility, mortality, wasting of body muscles, and bony lesions in the mandibles, ribs, metacarpus, and metatarsus regions. In these animals, colic, intermittent diarrhea, irregular reproductive cycles, repeated abortions, and still birth were also found as signs of nonskeletal fluorosis. In the study, an unusual pattern of dental staining was observed. Each incisor tooth had a single large deep-brownish spot surrounded by alternate light and deep stained thin layers and located towards the upper (incisal 3rd) region. A homogenous staining was also found at the bottom (gingival 3rd) part of incisors. The cause for this appearance of dental fluorosis in goats living in an industrial F polluted area is discussed.
Effects of nursery characteristics on field survival and growth of loblolly pine rooted cuttings.

Morphological characteristics of rooted cuttings and seedlings of four open-pollinated loblolly pine families cultured at the G.H. W. Weyerhaeuser Nursery near Washington, North Carolina were assessed after lifting. Cuttings were visually assigned to nine grading classes and six putative cull classes. The nine grading classes represented a factorial of three root collar diameter classes (small [4–6 mm], medium [6–8 mm] and large [8–10 mm]) and three root quality classes (poor, fair, and good). Putative cull classes included runts, poor foliage coverage, jumbos, “dog-legged” (one horizontal root at a right angle to the stem), multiple leaders, and excessive sweep. After assessment, the rooted cuttings and seedlings were established in a randomized block design on a coastal site in southern Beaufort County, North Carolina. Five years after establishment in the field, survival, height, diameter, presence or absence of fusiform rust incidence, number of leaders, and sweep were assessed. Analyses of variance were conducted to detect differences among the putative cull classes. Nursery rooting cutting morphological traits were regressed on fifth year field traits. Iterative logistic regression was performed between the nursery traits (continuous variables) and survival (binary variable). Overall, fifth year survival of the rooted cuttings was higher than that of the seedlings (77 versus 42%, respectively), and their stem volume was not significantly different from seedlings (0.259 versus 0.285 m3). For the four open-pollinated families studied, these results indicate that no culling standards are needed for rooted cutting planting stock to perform at least as well as seedling planting stock. However, eliminating cuttings with poor foliage coverage (less than 2.5 cm) and culling or pruning rooted cuttings with multiple leaders is recommended to reduce the number of forked trees in the field. South. J. Appl. For. 26(4):207–213.
Review on dermatomycosis: pathogenesis and treatment

Dermatophytes, a group of keratinophilic fungi thriving on the keratin substrate are the etio-logical agents responsible for causing cutaneous infections. Dermatophytosis is currently treated with the commercially available topical and oral antifungal agents in spite of the existing side effects. Treatment of these cutaneous infections with secondary metabolites produced by marine microorganisms is considered as a novel approach. For many years these organisms have been explored with the view of developing antibacterial, antifungal, antiviral, anti- cancer and antiparasitic drugs. Exploring the unexplored aspect of actinobacteria for developing antidermatophytic drugs is a novel attempt which needs further investigation.
Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence.

STUDY QUESTION Do platelets play any role in the development of endometriosis? SUMMARY ANSWER Activated platelets aggregate in endometriotic lesions and play important roles in the development of endometriosis. WHAT IS KNOWN ALREADY Platelets play important roles in cancer development and metastasis but there is no published study on their role in the development of endometriosis, even though endometriotic lesions undergo repeated cycles of tissue injury and repair, which characteristically involve platelets. STUDY DESIGN, SIZE, DURATION Cross-sectional clinical studies of women with and without endometriosis, in vitro experimentation, and animal studies using platelet and/or macrophage depletion. PARTICIPANTS/MATERIALS, SETTING, METHODS Immunohistochemistry analysis of ectopic/eutopic endometrial tissues from 58 women with and 47 without endometriosis. Proliferation assay, cell cycle analysis by flow cytometry, gene expression and protein analysis for COX-2, VEGF, MMP-9, and Bcl-2 using primary cell culture, and evaluation of the rate of platelet activation induced by peritoneal fluid from women with and without endometriosis. Two mouse experiments, one that evaluated the effect of platelet depletion on lesion development and its associated phenotypic changes, and the other, the effect of platelet and/or macrophage depletion. MAIN RESULTS AND THE ROLE OF CHANCE We found that platelets aggregated in endometriotic lesions, concomitant with elevated VEGF expression and microvessel density. Co-culture of endometriotic stromal cells with platelets enhanced cellular proliferation, and increased the expression of COX-2, MMP-9, VEGF, and Bcl-2. IL-1β-induced COX-2 up-regulation and increased production of the coagulant TXA(2) in endometriotic stromal cells. Tissue factor (TF) expression was elevated in endometriosis and TF concentrations were significantly elevated both in the supernatant of cultured primary endometriotic stromal cells and in peritoneal fluid from women with endometriosis. Platelet depletion resulted in significantly reduced lesion size and improved hyperalgesia in mice with induced endometriosis. LIMITATIONS, REASONS FOR CAUTION This study is limited by its cross-sectional design and by its focus on ovarian endometriomas. WIDER IMPLICATIONS OF THE FINDINGS The demonstration that platelets are involved in the development of endometriosis provides a rationale for the use of anti-coagulants to treat endometriosis, and opens prospects for developing novel biomarkers for diagnostic or prognostic purposes. STUDY FUNDING/COMPETING INTERESTS Financial support for this study was provided by grants from the National Science Foundation of China, a grant from the Shanghai Science and Technology Commission, support from the Key Specialty Project of the Ministry of Health, People's Republic of China. None of the authors has any conflict of interest to disclose.
Analysis of As 2 S 3 -Ti: LiNbO 3 Taper Couplers Using Supermode Theory

In this work, we develop a simulation method based on supermode theory and transfer matrix formalism, and then apply it to the analysis and design of taper couplers for vertically integrated As2S3 and Ti: LiNbO3 hybrid waveguides. Test structures based on taper couplers are fabricated and characterized. The experimental results confirm the validity of the modeling method, which in turn, is used to analyze the fabricated couplers.
Follow-Up in Carriers of the ‘MELAS’ Mutation without Strokes

Eight carriers of the A3243G mutation of mitochondrial DNA without stroke-like episodes were monitored for up to 7 years in clinical and metabolic studies, by magnetic resonance imaging (MRI) and positron emission tomography (PET). None developed mitochondrial encephalopathy (MELAS), but 2 developed diabetes mellitus, 1 terminal kidney failure and 2 cardiomyopathy. One patient improved markedly under ubiquinone. Electroencephalography showed progressive slowing in 2 cases, but electrophysiological tests and MRI were otherwise noncontributary. PET showed widespread cortical and basal ganglion metabolic deficits in 6 cases. We conclude that internal medical complications are more common than MELAS in adult carriers of the mutation. PET findings, firstly reported in such patients, suggest that chronic subclinical encephalopathy is very frequent, and PET may play a role in monitoring in the future.
Ouabain Changes Arterial Blood Pressure and Vascular Reactivity to Phenylephrine in l-NAME–Induced Hypertension

Ouabain is an endogenous compound that has been associated with the genesis and maintenance of hypertension. This compound inhibits the Na+ pump activity, which leads to an accumulation of intracellular Na+ and ultimately might increase vascular tone. In nanomolar concentrations, it enhances vasopressor responses to phenylephrine in some vascular beds from normotensive and hypertensive rats. However, it is not known whether this action of ouabain is a common mechanism for all models of hypertension. The aim of this work was to determine whether ouabain can alter pressor responses to phenylephrine in rats with Nω-nitro-l-arginine methyl ester (l-NAME)–induced hypertension. In anesthetized rats, ouabain (0.18 &mgr;g/kg, i.v.) increased arterial blood pressure in l-NAME–treated rats but not in controls. Ganglionic blockade by hexamethonium (5 mg/kg, i.v.) prevented the increase in arterial blood pressure produced by ouabain in l-NAME–treated rats. Additional studies using isolated perfused tail artery preparations were performed to investigate which factors are involved in the action of ouabain in l-NAME–treated rats. The effects of 10 n M ouabain on the vasoconstrictor actions of phenylephrine were determined on preparations with intact or damaged endothelium or in the presence of tetraethylammonium (a K+-channel blocker). Ouabain reduced pressor actions of phenylephrine in preparations with an intact endothelium. However, after endothelial damage or infusing tetraethylammonium, the response to phenylephrine was increased after ouabain. In tails from l-NAME–treated rats, the functional activity of the Na+, K+-ATPase was reduced, and 10 n M ouabain did not produce any further reduction. In conclusion, in this model of hypertension, a low dose of ouabain (0.18 &mgr;g/kg) increased arterial blood pressure in vivo probably as a result of increased sympathetic tone. However, this effect was not accompanied by an enhanced action of phenylephrine on the tail vascular bed with an intact endothelium. The results suggest that this was due to the release of an endothelium-derived K+-channel opener.
Bringing the state into the clinic? Incorporating the rapid diagnostic test for malaria into routine practice in Tanzanian primary healthcare facilities

ABSTRACT The roles that rapid, point-of-care tests will play in healthcare in low-income settings are likely to expand over the coming years. Yet, very little is known about how they are incorporated into practice, and what it means to use and rely upon them. This paper focuses on the rapid diagnostic test for malaria (mRDT), examining its introduction into low-level public health facilities in Tanzania within an intervention to improve the targeting of costly malaria medication. We interviewed 26 health workers to explore how a participatory training programme, mobile phone messages, posters and leaflets shaped the use and interpretation of the test. Drawing on notions of biopolitics, this paper examines how technologies of the self and mechanisms of surveillance bolstered the role mRDT in clinical decision-making. It shows how the significance of the test interacted with local knowledge, the availability of other medication, and local understandings of good clinical practice. Our findings suggest that in a context in which care is reduced to the provision of medicines, strict adherence to mRDT results may be underpinned by increasing the use of other pharmaceuticals or may leave health workers with patients for whom they are unable to provide care.
Root-knot Nematode Resistance in Cucumber and Horned Cucumber

Cucumber (Cucumis sativus L.) and horned cucumber ( C. metuliferus Naud.) germplasm were evaluated for their resistance to root-knot nematodes (Meloidogyne spp.). All 24 C. metuliferus cultigens evaluated were resistant to all root-knot nematodes tested- M. incognita (Kofoid and White) Chitwood race 3, M. arenaria (Neal) Chitwood race 2, and M. hapla Chitwood. All 884 C. sativus cultigens (cultivars, breeding lines, and plant in- troduction accessions) tested were resistant to M. hapla and few to M. incognita race 3. Only 50 of 884 C. sativus cultigens evaluated were somewhat resistant to M. arenaria race 2 and M. incognita race 3. A retest of the most resistant C. sativus cultigens revealed that LJ 90430 (an accession of C. sativus var. hardwickii (R.) Alef. ) and 'Mincu' were the only cultigens that were moderately resistant to M. arenaria race 2. LJ 90430 was the only cultigen, besides the two retested C. metuliferus cultigens, that was resistant to M. javanica (Treub) Chitwood. All C. sativus cultigens retested, including LJ 90430, were highly susceptible to M. incognita races 1 and 3. The two C. metuliferus cultigens retested were highly resistant to all root-knot nematodes tested- M. arenaria race 2, M. incognita races 1 and 3, and M. javanica.
No resuscitation orders and withdrawal of therapy in French paediatric intensive care units

Objective: To determine the incidence of different modes of death in French paediatric intensive care units and to compare patients’characteristics, including a severity of illness score (Paediatric Risk of Mortality: PRISM score) and prior health status (Paediatric Overall Performance Category scale), according to the mode of death. Design: A 4‐month prospective cohort study. Setting: Nine French multidisciplinary paediatric intensive care units. Patients: All patients who died in PICUs, except premature babies. Main results: Among 712 admissions, 13% patients died. Brain death was declared in 20%, failure of cardiopulmonary resuscitation occurred in 26%, do‐not‐resuscitate status was identified in 27%, and withdrawal of supportive therapy was noted in 27%. The PRISM score and the baseline Paediatric Overall Performance Category were not different between the four groups. Brain‐dead patients were older than those in whom a do‐not‐resuscitate order and withdrawal of therapy were made (median age 81 vs 7 and 4 months). Conclusions: Decisions to limit or to withdraw supportive care were made for a majority of patients dying in French paediatric intensive care units. Chronic health evaluation and severity of illness index are not sufficient to describe dead‐patient populations.
Liberating Psychotherapy: Liberation Psychology and Psychotherapy with LGBT Clients

SUMMARY This paper argues that neither science nor psychotherapy can be separated from values, and it calls on the insights of liberation psychology to examine the role of the social and the political in understandings of lesbian, gay, bisexual, and transgender (LGBT) experiences. Liberation psychology challenges the separation between the personal and the social, suggesting that their interwoven quality provides fertile ground for both personal and social change. Using the concept of internalized homophobia as an illustrative construct, the paper explores strategies for bringing these understandings to bear in psychotherapy with LGBT people, as well as in interventions that move beyond the therapy hour.
Baire spaces and hyperspace topologies

Sufficient conditions for abstract (proximal) hit-and-miss hyperspace topologies and the Wisjman hyperspace topology, respectively are given to be Baire spaces, thus extending results of [MC],[B1],[C]. Further the quasi-regularity of (proximal)hit-and-miss topologies is investigated.