Miracle-dz/UniFAR-FTUs huggingface dataset:
Malware Clustering Using Family Dependency Graph

Malware brings a major security threat on the Internet today. It is not surprising that much research has concentrated on detecting malware. Unfortunately, the current malware detection approaches suffer from ineffective detection of new malware samples. These models effectively identify the known malware samples but not new variants. To address this issue, we propose a novel malware detection approach based on the family graph. First, we trace the API calls of the monitored application, and then we generate the dependency graph based on the dependency relationship of the API calls. At last, we construct the family dependency graph via clustering the graphs of a known malware family. In this way, we can determine whether a new sample belongs to a known malware family. The evaluation results show that our approach is effective with small overhead compared to other existing approaches.
The Gc2 Allele of the Vitamin D Binding Protein Is Associated with a Decreased Postmenopausal Breast Cancer Risk, Independent of the Vitamin D Status

Vitamin D pathway gene polymorphisms may influence breast cancer risk by altering potential anticarcinogenic effects of vitamin D. The association between polymorphisms in the vitamin D binding protein (Gc) and postmenopausal breast cancer risk, with additional focus on the influence of serum 25-hydroxyvitamin D [25(OH)D], the biomarker for vitamin D status in humans, has not been examined thus far. We assessed the combined effects of two known functional polymorphisms in the Gc gene (rs4588 and rs7041), composing the phenotypic alleles Gc1s, Gc1f (combined: Gc1), and Gc2, on postmenopausal breast cancer risk and potential effect modification by 25(OH)D status in a population-based case-control study including 1,402 cases and 2,608 matched controls. Odds ratios (OR) for breast cancer risk adjusted for potential confounders were calculated for Gc genotypes. ANOVA was used to compare geometric means of serum 25(OH)D across Gc genotypes. Serum 25(OH)D concentrations in the control group significantly differed by Gc genotype, being lowest in Gc2 allele carriers. The geometric means of 25(OH)D were 53.0, 47.8, and 40.4 nmol/L for Gc1-1, Gc2-1, and Gc2-2 genotypes, respectively (Ptrend < 0.0001). Gc2-2 genotype was associated with a significantly decreased risk of postmenopausal breast cancer with an odds ratio (95% confidence interval) of 0.72 (0.54-0.96), compared with homozygote Gc1s allele carriers. No interaction between 25(OH)D status and Gc genotype was observed, nor did the association change considerably after adjustment for 25(OH)D status. Our results provide evidence for a serum 25(OH)D-independent effect of Gc2 allele carrier status in postmenopausal breast cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(6):1339–43)
Risk versus Ambiguity and International Security Design

We study portfolio allocation in the international financial market when investors exhibit ambiguity aversion towards assets issued in foreign locations. Entrepreneurs located in each country have access to a risky technology and want to attract capital. We characterize contracts issued by firms in such an environment. Increases in the variance of the risky production process causes firms to increase the variable payment (equity) offered to investors. On the other hand, increases in investor ambiguity lead to less risk-sharing. Entrepreneurs located in countries with low levels of domestic wealth issue assets with a higher fixed payment and a lower risky payment. As a result, they are exposed to higher volatility per unit of consumption as they finance themselves relatively more through debt than equity. An increase in ambiguity or ambiguity aversion that characterizes crises may explain flight of capital to capital-abundant countries - dubbed sometimes as "flight to quality".
Contextual Region-Based Convolutional Neural Network with Multilayer Fusion for SAR Ship Detection

Synthetic aperture radar (SAR) ship detection has been playing an increasingly essential role in marine monitoring in recent years. The lack of detailed information about ships in wide swath SAR imagery poses difficulty for traditional methods in exploring effective features for ship discrimination. Being capable of feature representation, deep neural networks have achieved dramatic progress in object detection recently. However, most of them suffer from the missing detection of small-sized targets, which means that few of them are able to be employed directly in SAR ship detection tasks. This paper discloses an elaborately designed deep hierarchical network, namely a contextual region-based convolutional neural network with multilayer fusion, for SAR ship detection, which is composed of a region proposal network (RPN) with high network resolution and an object detection network with contextual features. Instead of using low-resolution feature maps from a single layer for proposal generation in a RPN, the proposed method employs an intermediate layer combined with a downscaled shallow layer and an up-sampled deep layer to produce region proposals. In the object detection network, the region proposals are projected onto multiple layers with region of interest (ROI) pooling to extract the corresponding ROI features and contextual features around the ROI. After normalization and rescaling, they are subsequently concatenated into an integrated feature vector for final outputs. The proposed framework fuses the deep semantic and shallow high-resolution features, improving the detection performance for small-sized ships. The additional contextual features provide complementary information for classification and help to rule out false alarms. Experiments based on the Sentinel-1 dataset, which contains twenty-seven SAR images with 7986 labeled ships, verify that the proposed method achieves an excellent performance in SAR ship detection.
Recurrent NAB2–STAT6 gene fusions and oestrogen receptor‐α expression in pulmonary adenofibromas

Pulmonary adenofibromas are rare benign fibroepithelial tumours of the lung with unknown histogenesis and an indolent clinical behaviour. Their stroma resembles that of solitary fibrous tumours, whereas the glands are composed of respiratory epithelium organized in a phyllodes‐like architecture. Differentiation of pulmonary adenofibromas from other more aggressive intrathoracic tumours is clinically relevant. However, their biology is unknown. Here, we sought to characterize pulmonary adenofibromas at a clinicopathological level and to define whether they could be underpinned by a highly recurrent somatic genetic alteration akin to tumours with similar morphology.
Effect of solid content and composition of hydroxypropyl methylcellulose-lipid edible coatings on physico-chemical and nutritional quality of 'Oronules' mandarins.

BACKGROUND Citrus fruit represent an important source of vitamin C, as well as other bioactive compounds. Edible coatings have the potential to extend shelf life of citrus by providing a semi-permeable barrier to water and gases, which depends on coating composition, solid content (SC), and cultivar. However, little is known about the effect of coatings on citrus nutritional quality. This work studies the effect of coating composition and SC of hydroxypropyl methylcellulose (HPMC)-beeswax (BW)-shellac coatings on the physico-chemical, sensory and nutritional quality of 'Oronules' mandarins. Coatings prepared at the same lipid content differed in the BW:shellac ratio (1:3 and 3:1) and SC of the formulations (40 and 80 g kg⁻¹). RESULTS The coating with 1:3 BW:shellac ratio and 80 g kg⁻¹ SC was the most effective controlling weight loss, although it was less effective than the commercial wax tested. Increasing SC had a greater effect than the BW:shellac ratio in fruit internal atmosphere and sensory quality, with the presence of off-flavour when coatings were applied at 80 g kg⁻¹ SC. Nutritional quality was not affected by the application of the different treatments. CONCLUSION HPMC-lipid coatings have the potential to extend shelf life of 'Oronules' mandarins. However, care should be taken controlling formulation SC to avoid the build-up of off-flavour.
Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

Excitotoxic neuronal death, associated with neurodegenerative disorders and hypoxic insults, results from excessive exposure to excitatory neurotransmitters. Glutamate neurotoxicity is triggered primarily by massive Ca2+ influx arising from overstimulation of the NMDA subtype of glutamate receptors. The underlying mechanisms, however, remain elusive. We have tested the hypothesis that mitochondria are primary targets in excitotoxicity by confocal imaging of intracellular Ca2+([Ca2+]i) and mitochondrial membrane potential (ΔΨ) on cultured rat hippocampal neurons. Sustained activation of NMDA receptors (20 min) elicits reversible elevation of [Ca2+]i. Longer activation (50 min) renders elevation of [Ca2+]i irreversible (Ca2+ overload). Susceptibility to NMDA-induced Ca2+ overload is increased when the 20 min stimuli are applied to neurons pretreated with electron transport chain inhibitors, thereby implicating mitochondria in [Ca2+]ihomeostasis during excitotoxic challenges. Remarkably, ΔΨ exhibits prominent and persistent depolarization in response to NMDA, which closely parallels the incidence of neuronal death. Blockade of the mitochondrial permeability transition pore by cyclosporin A allows complete recovery of ΔΨ and prevents cell death. These results suggest that early mitochondrial damage plays a key role in induction of glutamate neurotoxicity.
The Expert Cure? Exploring the Restorative Potential of Expertise for Public Satisfaction With Parties

The declining legitimacy of political parties has become something of a truism in political science discourse. Less often reflected upon is how these legitimacy problems could potentially be resolved. This article contributes to this underexplored issue by examining the restorative potential of expertise as a supplement to intra-party democracy. Building on an established literature on Stealth Democracy, we explore the potential for expert-inspired reforms to boost citizens’ satisfaction with parties. Using original survey questions, we provide evidence that a perceived lack of expert engagement in parties predicts citizen dissatisfaction, before using deliberative workshop data to distil traits that define the appeal of experts and expertise. This mixed-methods approach allows us to demonstrate some common desires of which parties should be aware, but also traits that make these ideas difficult to realise. Combining these insights, we argue that while expertise has appeal, parties face considerable challenges in satisfying citizens’ desires.
How important is the "social" in social networking? A perceived value empirical investigation

Purpose – The purpose of this paper is to report on a value-based empirical investigation of the adoption of Twitter social networking application. The unprecedented popularity of social networking applications in a short time period warrants exploring theory-based reasons of their success. Design/methodology/approach – A cross-sectional survey-based study to elicit user views on Twitter was conducted with participants recruited through the web site of a North-American university. Findings – All facets of perceived value considered in the study (utilitarian, hedonic and social) had a significant and relatively strong influence on consumer intent to use Twitter. Quite surprisingly for a social networking application, though, the social value facet had comparatively the weakest contribution in the use equation. Research limitations/implications – User value perception might have been influenced by the features of the actual social networking application under scrutiny (i.e. Twitter in this case). Practical .
Wnt/β-Catenin and Wnt5a/Ca2+ Pathways Regulate Proliferation and Apoptosis of Keratinocytes in Psoriasis Lesions

Background/Aims: Wnt5a is overexpressed in psoriasis lesions, however the mechanism by which Wnt5a is involved in the pathogenesis of psoriasis is not clear. To address this, the expression of Wnt5a in psoriatic lesions and its effect on keratinocyte cell proliferation and apoptosis was examined in vitro. Methods: The expression levels of WNT5A, and genes encoding its receptors frizzled2 (FZD2) and frizzled5 (FZD5) were examined in samples obtained from individuals with psoriasis and healthy controls. Knockdown of Wnt5a with short interfering (si)RNAs was performed in cultured HaCaT keratinocytes and normal human keratinocytes (NHK), and the expression of Wnt5a, protein kinase C (PKC), and β-catenin were determined, and cell cycle activity, proliferation and apoptosis were assessed. Results: The expression of WNT5A, FZD2 and FZD5 mRNA and protein were increased in psoriatic lesions. Wnt5a knockdown suppressed proliferation and induced apoptosis in HaCaT and NHK cells. Additionally, expression of PCNA, MKI67, CCND1, BCL2, CTNNB1, and genes encoding PKC and survivin were downregulated, whereas CASP3 was upregulated. The mRNA levels of the Wnt pathway inhibitors DKK1 and SFRP1 were upregulated, Western blotting analyses demonstrated reduction in β-catenin and PKC protein levels. Conclusion: Knockdown of Wnt5a suppresses the proliferation of keratinocytes and induces apoptosis by inhibiting the Wnt/β-catenin or Wnt5a/Ca2+ pathways.
Frequency dependence of NBTI in high-k/metal-gate technology

In this paper, frequency dependency of the Negative Bias Temperature Instability (NBTI) in a wide frequency range (10kHz ~ 500MHz) is investigated using on-chip test structure. The designed test structure allows measurement in AC and DC mode. Statistically meaningful AC/DC lifetime ratios are extracted after accelerated reliability stress and show a non-monotonic behavior. Random Telegraph Noise (RTN) trap analysis of a single defect is also carried out which reveals that trap located near interface with time constant 10-10~10-4s are responsible for such behavior. A model from trap occupancy of individual defects point of view is also proposed to justify with plausible reasons the non-monotonic behavior of AC/DC ratio in wide frequency range.
Anticardiolipin antibodies in pathogenesis of infertility.

BACKGROUND/AIM Antiphospholipid syndrome (APS) is an autoimmune disorder clinically characterized by arterial or venous thrombosis and/or specific obstetric complications and presence of antiphospholipid antibodies (aPL) in the serum. It occurs in 0.3% of pregnant women, while 1% of them have two spontaneous abortions. The aim of this study was to analyze the frequency of biphospholipid antibodies in pregnant women with recurrent spontaneous abortions. METHODS We analyzed 60 pregnant women who had two or more recurrent miscarriages. The control group included 60 healthy pregnant women. We analyzed titres of anticardiolipin (aCL) IgG and/or IgM with high titres (> 20 U/mL), lupus anticoagulant (LAC) antibodies and anti-beta-2 glycoprotein (b2-GP1) IgG as well as parameters of coagulation status of pregnant women. RESULTS Analyzing Spearman's rank correlation coefficient in a group of affected patients, we noticed a slightly positive correlation of lupus anticoagulants (LAC) with aCL antibodies of both classes, while the correlation with b2GP1 IgG was negative. Both classes of aCL antibodies and anti-b2GP1 IgG were in a discrete positive correlation with the given variables. In the control group, there was a lack of consistency in correlation of the study variables with LAC-aCl IgG, compared to the affected patients, and there was a standard negative coefficient of correlation with anti-b2GP1 IgG. The correlation ratio of anti-b2GP1 IgG was negative for all studied test parameters. Analysis of hemostatic parameters showed a statistically significant difference in the concentration of fibrinogen (p < 0.01) and thrombocyte count (p < 0.05) between the study and the control group of pregnant women. Lower mean values of fibrinogen (2.90 +/- 0.45 g/L) and lower thrombocyte count [(179.20 +/- 6.00) x 10(9)] were found in the study group of pregnant women with secondary infertility compared to the mean values of fibrinogen (3.60 +/- 0.55 g/L) and thrombocyte count [(236.05 +/- 5.10) x 10(9)] in the control group. Activated partial thromboplastin time and prothrombin time were statistically significantly prolonged (p < 0.05) in pregnant women with spontaneous abortions compared to controls, suggest anticoagulant activity. CONCLUSION In pregnant women with spontaneous abortions compared to healthy pregnant women slightly positive correlation of LAC with aCL antibodies of both classes, as well as a positive correlation of aCL antibodies with anti-b2GP1 IgG exist. On the other hand, hemostatic parameters values suggest an anticoagulatnt status in the blood of pregnant women with spontaneous abortions.
KELT-11b: A Highly Inflated Sub-Saturn Exoplanet Transiting the V = 8 Subgiant HD 93396

We report the discovery of a transiting exoplanet, KELT-11b, orbiting the bright (V = 8.0) subgiant HD 93396. A global analysis of the system shows that the host star is an evolved subgiant star with K, , , , and . The planet is a low-mass gas giant in a P = 4.736529 ± 0.00006 day orbit, with MP = 0.195 ± 0.018 , , g cm−3, surface gravity , and equilibrium temperature K. KELT-11 is the brightest known transiting exoplanet host in the southern hemisphere by more than a magnitude and is the sixth brightest transit host to date. The planet is one of the most inflated planets known, with an exceptionally large atmospheric scale height (2763 km), and an associated size of the expected atmospheric transmission signal of 5.6%. These attributes make the KELT-11 system a valuable target for follow-up and atmospheric characterization, and it promises to become one of the benchmark systems for the study of inflated exoplanets.
Taguchi Experiment Design for Investigation of Freshened Properties of Self-Compacting Concrete

Problem statement: The intent of this study was to apply of Taguchi Design Of Experiments (DOE) techniques in Self Compacting Concrete (SCC) freshened properties studies. Owing to a wide range of material content of Self Compacting Concrete (SCC), generally, a large number of experiments were usually required as to decide a suitable mixture for finding the needed requirements of SCC. Approach: For that purpose, Taguchi’s approach with an L18(21×37) orthogonal array and three-level factor to reduce the numbers of experiment was adopted. Six control factors, namely, contents of coarse aggregate, sand, cement, silica fume, water and superplasticizer were used. The mixtures were extensively tested in freshened state and to meet technical requirement of SCC. Four responses (slump flow, flow time, V-funnel, L-box and segregation resistance) were evaluated. Results: The result of this study showed that Taguchi method is a promising approach for optimizing mix proportions of SCC to meet several freshened concrete properties. Conclusion: This study has shown that it possible to design self compacting concrete with fulfilling the criteria. As it can be seen in the results of freshened concrete properties of produced concrete samples, they fulfilled the expected properties of SCC.
Optimum Reaction Conditions for 1,4-Anhydroerythritol and Xylitol Hydrodeoxygenation over a ReOx–Pd/CeO2 Catalyst via Design of Experiments

In this study, we demonstrate that for the simultaneous hydrodeoxygenation (HDO) of 1,4-anhydroerythritol a comparable yield of tetrahydrofuran is obtained at half the previously reported H2 pressure. The simultaneous hydrodeoxygenation was conducted using a heterogeneous ReOx–Pd/CeO2 catalyst. An L9 Taguchi design of experiment was enacted to elucidate the temperature, pressure, and catalyst loading effects on the yield of the HDO reaction by testing pressures ranging from 40 to 80 bar H2, temperatures of 100–180 °C, and Re loadings of 2–4 wt %. Our design showed that the yield of this reaction is significantly affected by the reaction temperature only. An L9 Taguchi design was conducted for xylitol simultaneous hydrodeoxygenation with pressures ranging from 5 to 10 bar H2, temperatures of 140–180 °C, and Re loadings of 2–4 wt %. The xylitol design elucidated the direct relation of pressure, and the inverse relation of temperature and catalyst loading, to yield with the optimal reaction condition being 1.
The relationship between obesity and health-related quality of life in Chinese patients with schizophrenia

Abstract Objective. Studies have reported that up to 60% of individuals with schizophrenia are overweight or obese. This study explored the relationship between obesity and health-related quality of life (HRQoL) in Chinese patients with schizophrenia. Methods. A total of 1,108 patients with schizophrenia aged 18–50 years were recruited from 10 different sites in China. Demographic and medical information were collected; the Mandarin version of Short Form 36 Health Survey questionnaire (SF-36) was used to assess HRQoL; in addition,height and weight were measured to calculate body mass index (BMI). BMI was categorized into underweight, normal weight, overweight and obese using cutoffs for Asian populations recommended by the World Health Organization. Results. Fifty-six percent of participants with schizophrenia were overweight or obese. A higher BMI was associated with significantly lower scores in physical functioning, role-physical, and physical component summary (p's ≤ 0.010). Obese patients with schizophrenia had significantly lower scores in 3 domains and physical component summary of the SF-36 compared with normal weight patients (p's ≤ 0.007). Conclusion. Obesity is associated with decreased HRQoL in Chinese patients with schizophrenia. Our findings suggest that the prevention and management of weight gain and obesity is important in improving HRQoL in patients who suffer from this devastating mental illness.
PENGARUH RELIGIUSITAS DAN REPUTASI TERHADAP MINAT MUZAKKI DALAM MEMBAYAR ZAKAT PROFESI (Studi Kasus di Kabupaten Ponorogo)

This study aims to analyse the factors that influence the interest of muzakki in paying zakat profession through zakat institution. The constructs used in this study are religiosity and reputation as the variables used in measuring the interest. This research was conducted in Ponorogo district. The research method used in this research is quantitative. The researcher approaches this study with survey method, in which the scale of instrument measurement used is the Likert scale as well as using purposive technique in sampling. The data analysis technique used in this research is regression analysis and the data is processed by using SPSS for windows version 20. The results of this study indicate that the factor of religiosity and reputation have a statistically significant effect on the interest of muzakki in paying zakat profession through zakat institution in Ponorogo district.