Miracle-dz/UniFAR-FTUs huggingface dataset:
"All the sheeps are dead. He murdered them": sibling pretense, negotiation, internal state language, and relationship quality.

Pretend play enactment, negotiation, internal state language, and sibling relationship quality were examined in 40 kindergarten-aged children with either an older (M age = 7.10 years) or younger (M age = 3.6 years) sibling. Dyads were identified as engaging in frequent (n = 20) or infrequent (n = 20) pretend play. Results indicated that frequent pretend play dyads engaged in more high-level negotiation, whereas infrequent pretend dyads preferred low-level negotiation strategies. Frequent pretend dyads were more likely to use internal state language, especially during high-level negotiation. Friendly sibling relationship quality was negatively related to pretend enactment, whereas conflict was negatively associated with internal state language. Discussion focuses on the sibling relationship as a context in which to investigate the links between aspects of pretend play, sibling relationship quality, and social understanding.
Exploring perceptions of non-Muslims towards Halal foods in UK

Purpose – There is a growing demand of Halal products and services in a number of non-Muslim countries. Although Muslim consumers have been studied in several research studies but there is dearth of empirical studies about the perceptions of non-Muslims towards Halal. The purpose of this paper is to investigate the perceptions of non-Muslims towards Halal products and services. Design/methodology/approach – The data were collected from non-Muslims of UK through snowball sampling technique. In total, 29 interviews were conducted. The consumer perceptions were explored about Halal foods. The qualitative data were analysed for thematic analysis by adopting Spiggle’s steps for data analysis. Findings – It was found out that majority of the non-Muslims have positive perceptions regarding the Halal products and services as far as quality is concerned. The themes which emerged from these interviews were quality, knowledge about Halal, acculturation and animal welfare issues. Research limitations/implications – T.
Untangling the Relationship between Displayed Emotions and Organizational Sales: The Case of Convenience Stores

It has been proposed that the emotions expressed by role occupants influence the behavior of others. We hypothesized a positive relationship between employees' display of pleasant emotions to customers and sales in retail stores and tested that relationship in a sample of 576 convenience stores. An unexpected negative relationship was observed. A subsequent qualitative study suggested that sales is an indicator of a store's pace, or the amount of time pressure on clerks and customers, and that pace leads to displayed emotions, with norms in busy settings supporting neutral displays and norms in slow settings supporting positive displays. Reanalysis of the quantitative data confirmed that clerks in rapidly paced stores with high sales and long lines were less likely to display positive feelings than clerks in slow-paced stores.
Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301.

PURPOSE We sought to characterize the pharmacokinetics (PK) and determine a tolerable dose of oral sorafenib in patients with hepatic or renal dysfunction. PATIENTS AND METHODS Patients were assigned to one of nine cohorts: cohort 1, bilirubin < or = upper limit of normal (ULN) and AST < or = ULN and creatinine clearance (CC) > or = 60 mL/min; cohort 2, bilirubin more than ULN but < or = 1.5x ULN and/or AST more than ULN; cohort 3, CC between 40 and 59 mL/min; cohort 4, bilirubin more than 1.5x ULN to < or = 3x ULN (any AST); cohort 5, CC between 20 and 39 mL/min; cohort 6, bilirubin more than 3x ULN to 10x ULN (any AST); cohort 7, CC less than 20 mL/min; cohort 8, albumin less than 2.5 mg/dL (any bilirubin/AST); and cohort 9, hemodialysis. Sorafenib was administered as a 400-mg dose on day 1 for PK, and continuous daily dosing started on day 8. RESULTS Of 150 registered patients, 138 patients were treated. With the exception of cohorts 6 and 7, at least 12 patients per cohort were assessable, and the dose level with prospectively defined dose-limiting toxicity in less than one third of patients by day 29 was considered tolerable. No significant associations between the sorafenib PK and cohort were found. CONCLUSION We recommend the following empiric sorafenib starting doses by cohort: cohort 1, 400 mg twice a day; cohort 2, 400 mg twice a day; cohort 3, 400 mg twice a day; cohort 4, 200 mg twice a day; cohort 5, 200 mg twice a day; cohort 6, not even 200 mg every third day tolerable; cohort 7, not defined; cohort 8, 200 mg each day; and cohort 9, 200 mg each day.
Diversity, distribution and exchange of blood parasites meeting at an avian moving contact zone

Research on contact zones has paid relatively little attention to host–parasite interactions, although these situations have important but different implications depending on whether one considers the host or the parasite's perspective. We investigated both the role of a host contact zone in parasite expansion and whether parasites could influence contact zone dynamics. We studied the diversity and the patterns of parasite exchange (genera Haemoproteus and Plasmodium) infecting two parapatric sibling passerines meeting at a moving contact zone in western Europe. We amplified and sequenced a fragment of the parasite cytochrome b gene. The expanding host harboured more diverse parasites, which might indicate a superior ability to face a diverse parasite fauna than the receding host. Prevalence was very high in both hosts, due to the frequent occurrence of two sister Haemoproteus lineages. Despite the recent movement of the contact zone, these two parasites fitted almost perfectly to the geographic range of their main host species. Yet, we found several cases of cross‐species infection in sympatric areas and evidences of asymmetrical spreading of parasites from the expanding host towards the receding host. Altogether, our results suggest that the host contact zone mainly acts as a barrier to parasite expansion even if recurrent host shifts are observed. Besides, they also support the idea that parasite‐mediated competition might contribute to the displacement of hosts’ contact zones, thereby emphasizing the role of parasitism on the population dynamics of sympatric species.
Modulation of ethylene responses by O RTH 1 overexpression reveals the biological significance of ethylene in rice seedling growth and development

In mammals, cadmium is widely considered as a non-genotoxic carcinogen acting through a methylation-dependent epigenetic mechanism. Here, the effects of Cd treatment on the DNA methylation patten are examined together with its effect on chromatin reconfiguration in Posidonia oceanica. DNA methylation level and pattern were analysed in actively growing organs, under short(6 h) and long(2 d or 4 d) term and low (10 mM) and high (50 mM) doses of Cd, through a Methylation-Sensitive Amplification Polymorphism technique and an immunocytological approach, respectively. The expression of one member of the CHROMOMETHYLASE (CMT) family, a DNA methyltransferase, was also assessed by qRT-PCR. Nuclear chromatin ultrastructure was investigated by transmission electron microscopy. Cd treatment induced a DNA hypermethylation, as well as an up-regulation of CMT, indicating that de novo methylation did indeed occur. Moreover, a high dose of Cd led to a progressive heterochromatinization of interphase nuclei and apoptotic figures were also observed after long-term treatment. The data demonstrate that Cd perturbs the DNA methylation status through the involvement of a specific methyltransferase. Such changes are linked to nuclear chromatin reconfiguration likely to establish a new balance of expressed/repressed chromatin. Overall, the data show an epigenetic basis to the mechanism underlying Cd toxicity in plants.
Aggregation of the High Affinity IgE Receptor Results in the Tyrosine Phosphorylation of the Surface Adhesion Protein PECAM-1 (CD31)*

One of the earliest events after aggregation of the high affinity receptor for IgE (FcεRI) on mast cells is the activation of protein tyrosine kinases resulting in tyrosine phosphorylation of numerous proteins. Using a monoclonal antibody raised against the rat basophilic leukemia RBL-2H3 cells, we identified that platelet/endothelial cell adhesion molecule 1 (PECAM-1 or CD31) was tyrosine phosphorylated in these cells. Aggregation of PECAM-1 did not induce a detectable increase in its tyrosine phosphorylation, nor did it result in degranulation. However, the minimal tyrosine phosphorylation of PECAM-1 in nonstimulated cells was dramatically increased after FcεRI aggregation. This receptor-induced tyrosine phosphorylation of PECAM-1 was an early event, independent of Ca2+ influx or of the activation of protein kinase C and of cell adhesion. PECAM-1 is an adhesion molecule that is required for the transmigration of leukocytes across the endothelium into sites of inflammation. Therefore tyrosine phosphorylation of PECAM-1 may modulate its interaction with other molecules, thereby regulating the migration of basophils into inflammatory sites.
Commitment to organisational change : the case of information system innovation

This study tested the generalisability of the Commitment to Organisational Change construct (Herscovitch & Meyer, 2002) in the context of an information system change within a non-Western environment. The sample comprised 106 employees (70% response rate) ofa large Namibian organisation and responses were analysed using STATISTICA 7.0. Results suggest that the construct comprises three dimensions and can indeed be generalised to apply to an information system innovation change. Affective and Normative Commitment to Organisational Change were both positively related to Compliance, Co-operation and Championing, whilst Continuance Commitment to Organisational Change was negatively related, or unrelated. Commitment to Organisational Change was not a better predictor of behavioural support than Organisational Commitment. Interestingly, Change Significance and Change Impact both play an important role in predicting behavioural support for information system change. Implications for theory and practice are discussed and recommendations for future research are made. Un ive rsi ty of Ca pe To wn
Effect of lung inflation on pulmonary diffusing capacity at rest and exercise.

Steady state measurements of the diffusing capacity of the lung are made at operational lung volume, whereas measurements by the breath-holding method are customarily made at full inspiration. The effect of lung inflation on diffusing capacity must be taken into account before the steady state and breath-holding methods can be validly compared. At rest the single breath diffusing capacity of the lung for CO (DLCO) increases as the lung is inflated, presumably due to expansion of the alveolar-capillary surface; the volume of blood in the pulmonary capillary bed does not increase (1-5). During exercise the diffusing capacity, measured at full inspiration, increases with pulmonary blood flow, and this increase is associated with expansion of the pulmonary capillary blood volume (1, 2, 6, 7). It is not known how changing the lung inflation affects the expansion of the pulmonary capillary surface and blood volume during exercise. To investigate this problem we measured DLCOby the breath-holding technique at different lung volumes at rest and exercise in five healthy adults. Measurements were made at two different alveolar oxygen tensions to calculate membrane diffusing capacity for carbon monoxide (DMco) and pulmonary capillary blood volume (Vc) by the method of Roughton and Forster (8). We have compared our measurements of diffusing capacity obtained by the breath-holding method with steady state measurements from other laboratories.
"Interdomain transfer between isomorphic topics in algebra and physics": Correction to Bassok and Holyoak (1989).

Three experiments examined transfer between two isomorphic subdomains of algebra and physics. The two areas were arithmetic-progression problems in algebra and constant-acceleration problems in physics. High school and college students who had learned one of these subtopics were presented with word problems that used either content from the domain they had originally studied or content based on the unfamiliar but analogous domain. Students who had learned arithmetic progressions were very likely to spontaneously recognize that physics problems involving velocity and distance can be addressed using the same equations. Analysis of problemsolving protocols revealed that the recognition was immediate and that the solutions were a straightforward application of the algebraic method. Such recognition occurred even when the algebraic procedures were taught using example word problems all of which were drawn from a single content area (e.g., "money" problems). In contrast, students who had learned the physics topic almost never exhibited any detectable transfer to the isomorphic algebra problems. In the only case of transfer from physics to algebra, the process was analogical in nature. In addition, transfer from algebra to physics word problems was impaired if the physics transfer problems were embedded in a discussion of motion concepts. The results were interpreted in terms of content-free versus content-specific applicability conditions for mathematical procedures.
Construction of a tyrP-lac operon fusion strain and its use in the isolation and analysis of mutants derepressed for tyrP expression

The gene tyrP, which codes for a component of the tyrosine-specific transport system, has been localized on the Escherichia coli K-12 chromosome at min 42. A tyrP-lac operon fusion was constructed and used to isolate mutants that have altered expression from the tyrP promoter. All putative tyrP operator mutations were transferred onto a plasmid vector by recombination in vivo. Restriction enzyme analysis of the resultant plasmids suggests that some of these mutants arose from either an insertion or a deletion of DNA occurring within the region of DNA that contains the tyrP promoter.
Downlink capacity evaluation of cellular networks with known-interference cancellation

Recently, the capacity region of a multiple-input multiple-output (MIMO) Gaussian broadcast channel, with Gaussian codebooks and known-interference cancellation through dirty paper coding, was shown to equal the union of the capacity regions of a collection of MIMO multiple-access channels. We use this duality result to evaluate the system capacity achievable in a cellular wireless network with multiple antennas at the base station and multiple antennas at each terminal. Some fundamental properties of the rate region are exhibited and algorithms for determining the optimal weighted rate sum and the optimal covariance matrices for achieving a given rate vector on the boundary of the rate region are presented. These algorithms are then used in a simulation study to determine potential capacity enhancements to a cellular system through known-interference cancellation. We study both the circuit data scenario in which each user requires a constant data rate in every frame and the packet data scenario in which users can be assigned a variable rate in each frame so as to maximize the long-term average throughput. In the case of circuit data, the outage probability as a function of the number of active users served at a given rate is determined through simulations. For the packet data case, long-term average throughputs that can be achieved using the proportionally fair scheduling algorithm are determined. We generalize the zero-forcing beamforming technique to the multiple receive antennas case and use this as the baseline for the packet data throughput evaluation.
Psychological Distress and the Development of Hypertension Over 5 Years in Black South Africans

Alarming increases in the incidence of hypertension in many low‐ and middle‐income countries are related to alcohol overuse. It is unclear whether alcohol overuse is a symptom of psychological distress. The authors assessed psychological distress in Africans and its relationship with a 5‐year change in blood pressure (BP), independent of alcohol intake. The authors followed 107 Africans with optimal BP (≤120/80 mm Hg) (aged 35–75 years) over 5 years. Alcohol intake (self‐report and serum γ‐glutamyl transferase) and nonspecific psychological distress (Kessler Screening Scale for Psychological Distress [K6]) were assessed. The K6 predicted hypertension development (P=.019), and its individual component “nervous” increased a participant's risk two‐fold to become hypertensive (hazard ratio, 2.00 [1.23–3.26]). By entering K6 and γ‐glutamyl transferase into multivariable‐adjusted regression models for change in systolic BP, both were independently associated with change in systolic BP. Psychological distress and scoring high on being nervous predicted the development of hypertension over 5 years, independent of alcohol intake.
Regoverning Markets : A Place for Small-Scale Producers in Modern Agrifood Chains?

Contents: Foreword. Part 1 The Economic and Policy Context: The internationalization of food retailing: opportunities and threats for small-scale producers. Part 2 Country Studies: Countries with Consolidating and Expanding Supermarkets and Their Supply Chains: Central America, case studies Ecuador, case studies Thailand, case studies Philippines, case studies South Africa, case studies. Part 3 Country Studies: Countries in Transition from State Control: Hungary, case studies Poland, case studies Romania, case studies China, case studies Vietnam, case studies. Part 4 Country Studies: Countries with Emerging Modern Supply Chains: India, case studies Pakistan, case studies Bangladesh, case studies Kenya, case studies Uganda, case studies Zambia, case studies. Part Five Conclusions: Restructuring of agri-food systems and prospects for small producers. Index.
Surgery for ischemic mitral regurgitation: should the valve be repaired?

BACKGROUND AND AIM OF THE STUDY Patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting (CABG) often have concomitant mitral regurgitation (MR). Repairing the valve at the time of surgery is not universally accepted. The results of CABG with or without mitral valve annuloplasty (MVA) were compared in patients with reduced left ventricular (LV) function and ischemic MR. METHODS Among a total of 195 patients, 108 underwent isolated CABG, and 87 underwent CABG with MVA. The study end-points included survival, degree of MR, and NYHA functional class. RESULTS Patients in the MVA group were younger (mean age 63 +/- 10 versus 68 +/- 9 years; p <0.001), but had a more severe cardiac pathology, with severe LV dysfunction in 45% versus 26% (p = 0.006) and severe MR in 82% versus 14% (p < 0.001). The operative mortality was 9%, and similar in both groups. The follow up was complete, with a mean survival period of 87 +/- 50 months. Although, overall, no improvement was seen in LV function, symptomatic improvement was more pronounced in the MVA group (p = 0.006). At follow up, residual MR was present in 2% of the MVA group and in 47% of the CABG-only group (p < 0.0001). For the MVA and CABG-only groups, respectively, survival at five and 10 years was 68% and 46% versus 77% and 52% (p = NS). By multivariate analysis, neither degree of MR nor LV function at follow up had any impact on survival. CONCLUSION In patients with a reduced LV function undergoing CABG, the addition of a mitral annuloplasty does not increase the operative risk. Although patients in the MVA group were more ill, there was a better symptomatic improvement in this group, and they attained a similar survival. It is recommended that MVA be performed at the time of CABG in patients having moderate or greater MR associated with a reduced LV function.
Initializing neural networks for hierarchical multi-label text classification

Many tasks in the biomedical domain require the assignment of one or more predefined labels to input text, where the labels are a part of a hierarchical structure (such as a taxonomy). The conventional approach is to use a one-vs.-rest (OVR) classification setup, where a binary classifier is trained for each label in the taxonomy or ontology where all instances not belonging to the class are considered negative examples. The main drawbacks to this approach are that dependencies between classes are not leveraged in the training and classification process, and the additional computational cost of training parallel classifiers. In this paper, we apply a new method for hierarchical multi-label text classification that initializes a neural network model final hidden layer such that it leverages label co-occurrence relations such as hypernymy. This approach elegantly lends itself to hierarchical classification. We evaluated this approach using two hierarchical multi-label text classification tasks in the biomedical domain using both sentence- and document-level classification. Our evaluation shows promising results for this approach.
Comparing the "typical score" across independent groups based on different criteria for trimming

Nonnormality and variance heterogeneity affect the validity of the traditional tests for treatment group equality (e.g. ANOVA F-test and t-test), particularly when group sizes are unequal. Adopting trimmed means instead of the usual least squares estimator has been shown to be mostly affective in combating the deleterious effects of nonnormality. There are, however, practical concerns regarding trimmed means, such as the predetermined amount of symmetric trimming that is typically used. Wilcox and Keselman proposed the Modified One- Step M-estimator (MOM) which empirically determines the amount of trimming. Othman et al. found that when this estimator is used with Schrader and Hettmansperger's H statistic, rates of Type I error were well controlled even though data were nonnormal in form. In this paper, we modified the criterion for choosing the sample values for MOM by replacing the default scale estimator, MADn, with two robust scale estimators, Sn and Tn , suggested by Rousseeuw and Croux (1993). To study the robustness of the modified methods, conditions that are known to negatively affect rates of Type I error were manipulated. As well, a bootstrap method was used to generate a better approximate sampling distribution since the null distribution of MOM-H is intractable. These modified methods resulted in better Type I error control especially when data were extremely skewed.
Rad50 Is Not Essential for the Mre11-Dependent Repair of DNA Double-Strand Breaks in Halobacterium sp. Strain NRC-1

ABSTRACT The genome of the halophilic archaeon Halobacterium sp. strain NRC-1 encodes homologs of the eukaryotic Mre11 and Rad50 proteins, which are involved in the recognition and end processing of DNA double-strand breaks in the homologous recombination repair pathway. We have analyzed the phenotype of Halobacterium deletion mutants lacking mre11 and/or rad50 after exposure to UV-C radiation, an alkylating agent (N-methyl-N′-nitro-N-nitrosoguanidine), and γ radiation, none of which resulted in a decrease in survival of the mutant strains compared to that of the background strain. However, a decreased rate of repair of DNA double-strand breaks in strains lacking the mre11 gene was observed using pulsed-field gel electrophoresis. These observations led to the hypothesis that Mre11 is essential for the repair of DNA double-strand breaks in Halobacterium, whereas Rad50 is dispensable. This is the first identification of a Rad50-independent function for the Mre11 protein, and it represents a shift in the Archaea away from the eukaryotic model of homologous recombination repair of DNA double-strand breaks.