Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship between Teamwork and Team Performance: Experiences from an ERPsim Competition

Much interest exists in using Enterprise Resource Planning simulation (ERPsim) games to help students learn complex concepts involved in Enterprise Resource Planning (ERP) systems. However, little research has explored factors that contribute to team performance during an ERPsim game. The current study investigated teamwork as a contributor to team performance in the context of a competition. The research measured teamwork in five dimensions: contributing to the team’s work, interacting with teammates, keeping the team on track, expecting quality, and having relevant knowledge, skills, and abilities (KSA). Net income was the measure for team performance. Participants also rated their satisfaction with their team. Data from 62 student teams showed that all 5 teamwork dimensions had a positive correlation with net income. Moreover, all correlations were statistically significant except the relationship between keeping the team on track and net income. Teams with relevant KSA were more likely to generate higher net income. Expecting quality was the second most significant dimension, followed by interacting with teammates and contributing to the team’s work. All five teamwork dimensions had a significant positive correlation with team satisfaction. This research suggests that students will likely engage in good teamwork during a game if it is set up as a high-stakes competition. Additionally, good teamwork will likely result in higher team performance and satisfaction. The evidence should encourage more widespread adoption of ERPsim games as a means for teaching and assessing teamwork in addition to learning ERP concepts.
Air quality index and cardiovascular risk factors among automobile technicians in Southwest Nigeria

Background: Prolonged inhalational injury among automechanics may predispose them to increased oxidative process and cardiovascular diseases. This study was aimed at describing air quality index and pattern of cardiovascular risk factors among automechanics in Ogbomoso, Nigeria. Materials and Methods: One hundred and three automechanics were randomly recruited from Ogbomoso, Nigeria. Demographic and clinical parameters were collected. Cardiovascular risk factors were assessed. Air quality sampling was done using the gt-321 particle counter. Statistical analysis was done using SPSS 18.0. Results: The mean age of the study participants was 38.54 ± 11.94 years. The prevalence of cardiovascular risk factors among the study participants was hypertension (25.2%), low high-density lipoprotein-cholesterol (45.6%), elevated low-density lipoprotein-cholesterol (29.1%), and hypercholesterolemia (26.2%). The air quality index for particulate matter (PM)2.5were often three to five times higher than average 24 h mean in urban centers and more than 10 times the total annual mean. Similarly, average PM10,7,4and total suspended particle(TSP) were also significantly higher in automechanic workshops compared to the average urban measure of air quality index reported in 2014. Conclusion: Air quality indices around autotechnicians workshop are very poor. Cardiovascular risk factors such as hypertension and dyslipidemia still occur frequently among automechanic despite their high physical activity. Proper automobile and emission control and implementation of workplace protection are advised to minimize the impact of air pollution on automechanics in Nigeria.
Response to Comment by Jonathan Weiss et al.

We are very grateful to Weiss et al. for their confirmatory finding of acquired BCL2 mutations in patients with chronic lymphocytic leukemia (CLL) who became resistant to venetoclax treatment. We had identified mutations in BCL2 as a resistance mechanism characterizing patients with slowly outgrowing, refractory CLL after at least 3 years of continuous therapy with venetoclax. Correspondingly, Blomberry et al. had previously identified BCL2 variants up to 25 months before progressive disease in patients with CLL on long-term treatment with venetoclax. In contrast, the patient cohort studied by Herling et al. progressed after 4-22 months with CLL characterized by genomic features of Richter transformation. Indeed, half of their patients had histologically confirmed Richter syndrome and it was not reported if diagnostic attempts were made to exclude this in the remaining cases. The resistance mechanism of this aggressive phenotype may be different and the genomic characterization showed mainly variants known from aggressive lymphoma (e.g. tetraploidy, CDKN2A/B deletion, 8q gain). Such aggressive clones may outperform and abolish the slow outgrowth of BCL2 variants, which at this early time point remain subclonal (see Figure). We can confirm the absence of BCL2 mutations in cases with accelerated CLL and Richter syndrome after venetoclax treatment from analyses at our center, but these events should be the exception and not the rule deduced from current clinical trials with venetoclax in earlier treatment lines. Moreover, the pattern of resistance with late occurring, specific mutations in CLL progression but not in early progression with transformed disease is analogous to what was observed in the context of ibrutinib treatment in CLL. Also in this scenario, early progressions were mostly Richter transformations devoid of BTK/PLCg2 mutations while late CLL progressions are characterized by such mutations in the vast majority of cases.
Flock use of the range is associated with the use of different components of a multi-tier aviary system in commercial free-range laying hens

ABSTRACT 1. The objective of this study was to investigate the association of using a multi-tier aviary system and access to range on flock uniformity in free-range laying hens, and to determine whether the extent of range use or flock uniformity can be predicted from the use of different levels of the aviary system. 2. A total of 13,716 Lohmann Brown hens from five commercial free-range flocks housed in identical houses on the same farm were individually weighed at 16 weeks of age and allocated to five replicate areas within each house. Hen movement in the multi-tier aviary system and on the range was individually monitored using radio frequency identification (RFID). All hens had access to the range from 18 to 22 weeks of age and were exposed to the same management conditions. 3. Whilst only one flock significantly changed its flock uniformity with time, they differed from each other in uniformity and body weight (P = 0.001). 4. Hens spent most of their available time on the lower aviary tier (7.29 ± 0.029 h/hen/day) and on the upper aviary tier (4.29 ± 0.024 h/hen/day) while the least amount of time was spent on the range and in the nest boxes (0.93 ± 0.005 h/hen/day and 1.48 ± 0.007 h, respectively, P = 0.001). 5. Range use was negatively correlated (r = −0.30) to the time spent on the upper aviary tier and positively correlated (r = 0.46) to the time spent on the lower aviary tier (P = 0.001). Bivariate analysis revealed that range and upper aviary resp. lower aviary tier usage had a significant curvilinear association. 6. In conclusion, the study showed that range use was associated to the time hens spent on the different tiers of the aviary system. Flock uniformity varied between flocks but was not associated with either range and aviary system usage.
Protein Structural Information and Evolutionary Landscape by In Vitro Evolution

Protein structure is tightly inter-twined with function according to the laws of evolution. Understanding how structure determines function has been the aim of structural biology for decades. Here, we have wondered instead whether it is possible to exploit the function for which a protein was evolutionary selected to gain information on protein structure and on the landscape explored during the early stages of molecular and natural evolution. To answer to this question, we developed a new methodology, which we named CAMELS (Coupling Analysis by Molecular Evolution Library Sequencing), that is able to obtain the in vitro evolution of a protein from an artificial selection based on function. We were able to observe with CAMELS many features of the TEM-1 beta lactamase local fold exclusively by generating and sequencing large libraries of mutational variants. We demonstrated that we can, whenever a functional phenotypic selection of a protein is available, sketch the structural and evolutionary landscape of a protein without utilizing purified proteins, collecting physical measurements or relying on the pool of natural protein variants.
A randomized clinical trial of chemotherapy compared to chemotherapy in combination with cetuximab in k-RAS wild-type patients with operable metastases from colorectal cancer: The new EPOC study.

3504 Background: Resection of liver metastases from colorectal cancer with or without neoadjuvant chemotherapy is the standard of care. The EPOC study (Nordlinger et al, Lancet 2008) randomised patients between surgery and surgery with chemotherapy and demonstrated an improvement in 3 year progression free survival (PFS) of 7·3% (from 28·1% to 35·4%). As a rational extension to the EPOC study data, the New EPOC study evaluates the benefit of cetuximab, an EGF receptor antibody, in addition to standard chemotherapy in patients with operable liver metastases. Methods: 272 patients were randomised between February 2007 and November 2012 into the New EPOC study. Eligible patients were required to be k-RAS wild type, have operable liver metastases and to be sufficiently fit for chemotherapy and surgery. Patients with the primary tumour in situ, and those who required short course rectal radiation were eligible. Patients were randomised to receive a fluoropyrimidine and oxaliplatin plus or minus cetuximab for 1.
What Is the Normal Ulnar Bow in Adult Patients?

BACKGROUND Rotation of the forearm is a result of the complex interaction among the radius, ulna, and interosseous membrane. Although the radius is recognized as curved, the ulna is generally thought of as a "straight bone. " To better describe normal anatomy, which may lead to more successful anatomic fixation of forearm fractures, we aimed to apply a method of measuring the normal ulnar bow and determine the mean ulnar bow in adults. QUESTIONS/PURPOSES (1) To what degree is the ulna bowed in the coronal and sagittal planes in normal adult forearms? (2) To what degree is the radius bowed in the coronal plane in normal adult forearms? METHODS Radiographs of the forearms of adults taken during a 1-year period were initially obtained retrospectively. These radiographs were performed for various reasons, including forearm pain and routine radiographic follow-up. Radiographs were excluded if evidence of a fracture or post-fracture fixation was found, if a patient had missing AP or lateral images, or if a suboptimal technique was used. The coronal and sagittal bow of the ulna was measured with a method adapted from previous studies that assessed radial bow using AP and lateral radiographs, respectively. Similar measurements were made in the coronal plane for the radius. All measurements were performed independently by the four authors. There was excellent interobserver reliability for ulnar bow in the coronal and sagittal planes (interclass correlation coefficient = 0.96 and 0.97, respectively) and for radial bow in the coronal plane (interclass correlation coefficient = 0.90). RESULTS The mean maximal coronal ulnar bow was 7 ± 2 mm and was located at 75% of the ulnar length, measured proximally to distally. The location of coronal bow was consistently distal to the radial bow location. The mean maximal sagittal ulnar bow was 6 ± 3 mm and was located at 39% of the ulnar length. The mean maximal coronal bow of the radius was 14 ± 2.0 mm and was 59% of the total length of the radius from proximal to distal. CONCLUSIONS The ulna is not a "straight bone," as is commonly thought, but rather has a bow in both the coronal and sagittal planes. CLINICAL RELEVANCE Knowledge of the standard ulnar bow may be pivotal to prevent malunion of the ulna during surgery. Future research using these data in preoperative planning may lead to changes in plate contouring and clinical outcomes in forearm fracture management.
Speech Perception, Dichotic Listening, and Ear Advantage in Simultaneous Bilateral Cochlear Implanted Children.

OBJECTIVE To study the development of dichotic listening, ear advantage, and speech perception in cochlear implant (CI) recipients using five audiometric tests. STUDY DESIGN Prospective cohort analysis. SETTING University Hospital. PATIENTS One hundred twenty one participants who received simultaneous bilateral CIs and had at least 12 months of regular bilateral CI use. Age at time of testing ranged from 4 to 18 years with a mean age of 9 years (standard deviation [SD]: 3.0). Mean duration of CI use was 7.073 years (SD: 2.86). INTERVENTION Bilateral simultaneous cochlear implantation. MAIN OUTCOME MEASURE Goettinger and Freiburger monosyllabic word test, Hochmair, Schulz and Desoyer sentence (HSM) test in noise and in quiet conditions and the dichotic listening test by Uttenweiler were applied according to the childrens' age. The results were evaluated using a two-sided t test for dependent samples. RESULTS In all tests applied, we could not show significant differences in performance between left and right CI and therefore could not demonstrate an ear advantage. Dichotic listening was challenging, only one subject produced results required for normal hearing subjects to pass the test. The older the CI recipients get and duration of CI use increases, the more results in all speech perception tests improve. CONCLUSIONS Our results cannot lend further support to the existence of ear advantage in CI recipients. We do not recommend the Uttenweiler dichotic listening test to determine lateralization. Further research to gather more information on dichotic listening and ear advantage in CI recipients is necessary and should use consonant-vowel stimuli as more comparable stimuli.
The Impact of Chronic Liver Disease on Postoperative Outcomes and Resource Utilization

Abstract Background Multiple studies have shown high rates of postoperative morbidity and mortality in individuals with chronic liver disease (CLD). However, analyses from comparisons with individuals without CLD are not available. Such analyses might provide opportunities to improve outcomes. Methods Data from The National Surgical Quality Improvement Program (NSQIP) from 2008 to 2011 were analyzed comparing CLD patients undergoing non-liver surgery propensity matched to those without CLD. Patients with CLD were stratified by Model of End Stage Liver Disease (MELD) scores <15 and ≥15. Primary outcome was all cause mortality, and secondary outcomes were composite and individual morbidity, hospital length of stay, readmission, reoperation, and discharge destination. Odds ratios (OR) were calculated, and length of hospital stay was estimated using Poisson regression. Results There were 6,209 patients with CLD (4,013 with low MELD, 2,196 with high MELD) matched to 18,627 patients without. Patients with CLD had 1.8- and 3.3-times higher odds of mortality (95% CI 1.6–2.1 for Low MELD (10.6%), 2.9–3.8 for high MELD (35.2%), and 1.8- and 2.2-times higher odds of any morbidity (1.6–1.9 and 1.9–2.4). Complications specific to CLD were increased based on MELD specifically coma (OR 1.6, 0.9–2.9 for Low MELD, 2.2, 1.5–3.2 for High MELD), renal failure (OR 1.4, 1.1–1.8 and 2.4, 2.0–2.9), and bleeding (OR 1.7, 1.5–1.9 and 2.0, 1.8–2.3). They also had a 20% and 80% longer length of stay, 2.2- and 3.4-times higher odds of being discharged somewhere other than home, 1.7- and 1.6-times higher odds of readmission, and 1.5- and 1.6-times higher odds of reoperation. Conclusion Patients with CLD have significantly higher odds of mortality and morbidity, which is increased with a higher MELD. Interventions that decrease those morbidities are needed and have the potential to decrease mortality and resource utilization.
ETHNOPHARMACOLOGY, INDIGENOUS COLLECTION AND PRESERVATION TECHNIQUES OF SOME FREQUENTLY USED MEDICINAL PLANTS OF UTROR AND GABRAL, DISTRICT SWAT, PAKISTAN

An ethnomedicinal study was conducted in the remote Hindukush-Himalayan valleys of Utror and Gabral, during which 36 common folk medicinal recipes of the area were documented. The indigenous methods of medicinal plants collection and their further processing were also explored. It was also observed that huge quantities of valuable medicinal plants are lost every year due to lack of proper collection, cleaning, packing and storage techniques on the part of local collectors.
Prevalence, Onset, and Course of Suicidal Behavior Among Adolescents and Young Adults in Germany

Key Points Question How frequently and when do suicidal ideation, plan, and attempt emerge in adolescence and young adulthood? Findings In a cross-sectional, epidemiological study of 1180 adolescents and young adults from a random community sample in Germany, 10.7%, 5.0%, and 3.4% of participants reported lifetime suicidal ideation, plan, and attempt, respectively. The cumulative incidence of suicidal behavior increased after age 10 years more strongly among female than male participants, and the transition from ideation to action occurred mostly during the same year. Meaning Adolescence and young adulthood are critical developmental periods for the onset of suicidal behavior, with a short time for targeted interventions to disrupt the ideation-to-action pathway.
A Case-Control Study to Compare the Likelihood of Detecting Liver Disorders Using Coincident Measures of Doppler-Derived Portal Vein Pressure Gradients, Hepatic Venous Waveforms, and the Echogenicity of Liver Parenchyma

A case-control study based on the records of 465 adult patients receiving abdominal sonograms predicted the likelihood of liver damage, as detected by serum biomarkers, biopsy, and/or endoscopy, to increase systematically with respect to (a) an increase in echogenicity from grade 1 (odds ratio [OR] = 2.94) through 2 (OR = 10.50) to 3 (OR = 14.91) coincident with (b) a dampening of the hepatic venous waveform (HVW) from biphasic (OR = 1.66) to monophasic (OR = 3.68) and (c) a simultaneous elevation in the portal vein pressure gradient, adjusted for portal vein diameter (PVPG) from level 1 (OR = 1.85) through 2 (OR = 3.23) to 3 (OR = 3.35). Echogenicity consistently exhibited higher sensitivities but lower specificities than the HVW and PVPG. The lowest specificities were found among patients with a body mass index >25, proposed to be associated with intrahepatic fat infiltration causing false positives in the absence of hepatopathology.
Parathyroid Cancer: A Review

Parathyroid cancer is one of the rarest causes of primary hyperparathyroidism and tends to present with more severe symptoms than its more benign counterparts. This article details various aspects of the disease process, including epidemiology, clinical presentation, and a step-wise diagnostic process for parathyroid cancer. This includes laboratory assessments as well as a proposed staging system. The en bloc principle of surgical intervention is detailed, as well as the current role of adjuvant treatments. A general guide to surveillance and the natural history of the disease is also outlined.
Long Noncoding RNA TP73-AS1 Targets MicroRNA-329-3p to Regulate Expression of the SMAD2 Gene in Human Cervical Cancer Tissue and Cell Lines

Background Worldwide, mortality from cervical cancer in women remains high. This study aimed to investigate the expression of long noncoding RNA (lncRNA) TP73-AS1, microRNA-329-3p (miRNA-329-3p), and the SMAD2 gene and their regulatory relationships in human cervical cancer tissue and cervical cancer cell lines. Material/Methods Cervical cancer tissue samples (n=30) and normal control cervical tissues were studied. Cell proliferation and migration were investigated in HeLa and SiHa human cervical cancer cells using the MTT assay, crystal violet staining, wound healing assay, and the transwell assay. Expression of lncRNA TP73-AS1 and the SMAD2 gene were detected using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot. Enrichment of miR-329-3p was measured using the RNA immunoprecipitation assay (RIPA). Targeting relationships between TP73-AS1, miR-329-3p, and SMAD2 were identified using the dual-luciferase reporter assay. A subcutaneous xenograft model was established, tumor size was measured, and SMAD2 expression was detected using immunohistochemistry. Results LncRNA TP73-AS1 was overexpressed in cervical cancer tissues and cells and was associated with reduced expression of miR-329-3p. Down-regulation of lncRNA TP73-AS1 inhibited cell proliferation, migration and invasion and increased miR-329-3p expression. Expression of SMAD2 down-regulated miR-329-3p and was associated with increased expression of TP73-AS1. LncRNA TP73-AS1 knockdown resulted in miR-329-3p silencing. In tumor xenografts, expression of TP73-AS1 reduced the tumor volume and down-regulated the expression levels of the SMAD2 gene. Conclusions LncRNA TP73-AS1 promoted proliferation of cervical cancer cell lines by targeting miR-329-3p to regulate the expression of the SMAD2 gene. A regulatory network was formed between lncRNA TP73-AS1, miR-329-3p, and SMAD2.
Stigmatization of posttraumatic stress disorder is altered by PTSD Knowledge and the precipitating trauma of the sufferer

Abstract Background Reducing stigma could improve well-being and decrease discrimination toward persons with mental illness. Aim The current study investigated the impact of posttraumatic stress disorder (PTSD) knowledge and the characteristics of a person suffering from PTSD symptoms on stigmatization. Method University students (n = 560) read one of twelve vignettes describing someone with PTSD symptoms who varied by gender, military status, and precipitating trauma. Then, participants rated their own responses to the person in the vignette (i.e. personal stigma), their perception of how others would respond (i.e. perceived stigma), and their comfort with the person in different social settings (i.e. social distance) followed by a PTSD Knowledge Questionnaire. Results PTSD knowledge was associated with decreased personal stigma and increased willingness to socialize with individuals in the vignettes. The precipitating trauma of the person in the vignette influenced perceived stigma ratings, lowering perceived stigma for those who had experienced a rape as opposed to a car accident. Neither the gender nor military status of the person in the vignette affected stigmatization. Conclusions The current findings underscore the importance of mental health education in reducing stigma and indicate that the type of precipitating trauma affects attitudes toward those with PTSD symptoms.