Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards an unbiased, collaborative effort to reach evidence about the presence of human cytomegalovirus in glioblastoma (and other tumors).

question of whether with human cytomegalovirus (HCMV) We reported our failure to detect HCMV in gliomas in Neuro-Oncology. 1 Our accompa-nied by 2 editorials, 2,3 one of which boldly criticized our approach. 3 Instead of ﬁghting a petty, ivory tower dispute, we like to lobby for a serious collaborative approach to pro-viding conclusive evidence on the presence of HCMV in glioma (and other cancers). Since we developed the of onco-modulation (ie, that HCMV may increase tumor malignancy by infecting established tumor cells and/or tumor-associated cells) desperate cancer patients they be treated with antiviral drugs. later, still do
Places and social contexts associated with simultaneous use of alcohol, tobacco and marijuana among young adults

INTRODUCTION AND AIMS Little is known about social-ecological correlates of simultaneous use of alcohol with other substances. This study examined places and social contexts associated with simultaneous use of alcohol, tobacco and marijuana among young adults. DESIGN AND METHODS We used survey data obtained from 1538 young adult recent alcohol drinkers (49% male; 18-30 years old) in 24 non-contiguous cities in California. Event-level measures included alcohol, tobacco and marijuana use, drinking places and social characteristics of the event. Individual-level measures included alcohol expectancies, depression and demographics. RESULTS Bars and restaurants had less alcohol and marijuana use (odds ratio = 0.34; 95% confidence interval 0.18, 0.62; P < 0.001) and alcohol, marijuana and tobacco use (odds ratio = 0.27; 95% confidence interval 0.14, 0.54; P < 0.001) compared with alcohol use only. Perceived percent of intoxicated people at an event was associated with greater likelihood of using alcohol with tobacco and marijuana at the event. At the individual level, greater age was generally associated with increased odds of simultaneous use. Participants who were male, less educated, more depressed and had positive alcohol expectancies were more likely to simultaneously co-use alcohol with tobacco and marijuana. Those with negative expectancies were less likely to simultaneously use these substances. DISCUSSION AND CONCLUSIONS Social events in private settings with a high percentage of people who are intoxicated had increased likelihood of simultaneous use of alcohol, tobacco and marijuana. Prevention efforts in these settings may reduce simultaneous use of these substances and related harms. [Lipperman-Kreda S, Paschall MJ, Saltz RF, Morrison CN. Places and social contexts associated with simultaneous use of alcohol, tobacco and marijuana among young adults. Drug Alcohol Rev 2017;00:000-000].
Myocardial infarction adjudication in contemporary all-comer stent trials: balancing sensitivity and specificity. Addendum to the historical MI definitions used in stent studies.

1. Cardialysis, Clinical Research Management & Core Laboratories, Rotterdam, The Netherlands; 2. Harvard Clinical Research Institute, Harvard Medical School, Boston, MA, USA; 3. Cardiovascular Research Foundation, Columbia University Medical Centre, New York, NY, USA; 4. Cardiology Practice and Hospital, Am Isarkanal, Munich, Germany; 5. Department of Cardiology and Clinical Trial Unit, Bern University Hospital, Bern, Switzerland; 6. Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
Wide Compatibility Gene Approaches and Heterosis Relationship in Japonica x Indica Hybrid Rice ( Oryza sativa L.)

A special class of rice germplasm, referred as wide-compatible can produce hybrids with enhanced spikelet fertility when crossed with japonica×indicia rice lines having neutral allele. Present study was conducted to identify the presence of neutral allele and relationship in the hybrid performance. The wide-compatible genotype screening resulted positive selection having neutral allele and responsible for increased spikelet fertility with possible utilization as donor parent in hybrid development programme for achieving higher yield. Combining ability and heterosis for grain yield and its component traits derived from japonica×indica experimental hybrids revealed higher general combining ability variance than their respective specific combining ability variances indicating the predominance of additive gene action, opened the way for fixing the yield contributing gene by breeding through transgressive selection. Most of the experimental hybrids showed significant and positive SCA effects for grain yield as well as several other yield related component traits. Wide compatibility gene investigation clearly demonstrated the utility of InDel primer in the identification of wide compatible genotypes possessing neutral allele at S5 locus. The genotypes having natural allele (281-bp) can give rise to fully fertile panicle and significant contribution towards yield and heterosis. Association index between genetic diversity and three SH of GY hybrids on the basis of microsatellite data set surprisingly exhibited significant and positive correlation indicated the possible utility of microsatellite markers for successful utilization and establishing the strong heterotic relationship.
Supine Versus Prone Position in Percutaneous Nephrolithotomy for Kidney Calculi: A Meta-Analysis.

BACKGROUND There are several positions in the operation of percutaneous nephrolithotomy (PCNL), such as prone position, supine position, flank position, and modified supine position for PCNL, but the supine and prone positions are the main two choices for several years. However, there is still discrepancy on the optimal position for PCNL. Therefore, we performed this meta-analysis to evaluate safety and efficacy of the supine versus the prone position in PCNL for renal calculi. METHODS We searched MEDLINE, SCOPUS, and the Cochrane database libraries to look for relevant studies. All eligible controlled trials comparing supine versus prone positions for treating renal calculi were included in the meta-analysis. The main outcome of efficacy (stone-free rate, mean operative time, and hospitalization time) and safety (complication, blood transfusions) were assessed by using Review Manager 4.2 software. We calculated the estimate of effect associated with the two positions according to the heterogeneity using random-effects or fixed-effects models. RESULTS Thirteen studies (six randomized controlled trials and seven retrospective studies) with a total of 6881 patients contributed to this meta-analysis. The meta-analysis indicated/suggested that PCNL in the prone position was associated with a higher rate of stone clearance than PCNL in the supine position (odds ratio [OR]: 0.74; 95% confidence interval [CI]: 0.65, 0.84; p < 0.00001). A shorter mean operative time was observed in the supine groups (weighted mean difference [WMD]: -18.27; 95% CI: -35.77, -0.77; p = 0.04). Compared with the prone position, there was also a lower incidence of blood transfusions in the supine groups (WMD: 0.73; 95% CI: 0.56, 0.95; p = 0.02). No difference was observed between the positions with regard to the hospital stay (WMD: -0.14; 95% CI: -0.76, 0.47; p = 0.65) and complications (OR: 0.88; 95% CI: 0.76, 1.02; p = 0.10). CONCLUSION Compared with the prone position, the PCNL in the supine position has a slightly lower rate of stone clearance, albeit shorter mean operative time, and lower incidence of blood transfusions. The meta-analysis suggests that the PCNL in the supine position is a promising alternative.
The Tetraspan Protein EMP2 Regulates Expression of Caveolin-1*

Caveolin-1 is the primary component of caveolae and functions in a variety of intracellular activities, including membrane trafficking and signal transduction. EMP2 (epithelial membrane protein 2) is a tetraspan protein recently identified as a novel regulator of caveolin-1 expression. In this study, we analyzed the mechanism of EMP2-mediated caveolin-1 regulation. In NIH 3T3 cells and in the human retinal pigment epithelium cell line (ARPE-19), EMP2 regulates caveolin-1 transcription and more substantially its protein levels. EMP2-mediated down-regulation of caveolin-1 does not affect caveolin-1 translational efficiency, phosphorylation, or proteasome-mediated degradation. Analysis of caveolin-1 protein half-life indicates the EMP2-mediated loss of caveolin-1 occurs rapidly. Protease inhibition and laser confocal microscopy associates this fate with specific intracellular compartmentalization, including early lysosomal delivery. These findings elucidate a new mechanism of caveolin-1 regulation and define an additional role for EMP2 as a key regulator of cell membrane composition.
Social Influence and Interpersonal Power in Organizations

This two-study investigation framed performance as one potential form of influence that interacts with political skill to affect power assessments. It was hypothesized that favorable performance is more likely to be leveraged into higher levels of interpersonal power when individuals possess high levels of political skill but not for individuals low in political skill. Study 1 (N = 97) demonstrated that individuals with positive performance were more likely to possess higher levels of interpersonal power if they were high in political skill. Furthermore, higher levels of performance were not related to power for individuals low in political skill. Thus, these results from Study 1 established support for the hypothesis. Study 2 (N = 384), using a multisource design, constructively replicated these findings. Contributions to theory and research, strengths and limitations, directions for future research, and practical implications are discussed.
TIWANA AND KEIL : FUNCTIONALITY RISK IN INFORMATION SYSTEMS DEVELOPMENT

Functionality risk is defined as the risk that a completed system will not meet its users’ needs. Understanding functionality risk is central to successful information systems development (ISD), yet much of the research in this area has focused on identification of risk factors and development of conceptual frameworks. Little is known about how various functionality risk factors collectively influence managers’ perceptions about the risk that a project will fail. As organizations become increasingly reliant on software, it is evermore important to understand functionality risk in ISD. In this paper , we develop an integrative model of functionality risk to explain the relative importance of six salient functionality risk factors that have been consistently identified in the prior ISD literature as being important: 1) related technical knowledge; 2) customer involvement; 3) requirements volatility; 4) development methodology fit; 5) formal project management practices; 6) project complexity. The model is tested empirically with 60 highly experienced MIS Directors in sixty organizations. In addition to providing empirical support for the proposed model, the relative importance of each of the key functionality risk factors is empirically assessed. Development methodology fit, customer involvement, and use of formal project management practices emerged as the top three functionality risk factors. Additional finer-grained analyses show that high methodology fit lowers several other sources of risk. Implications for research and practice are discussed.
Memristor Crossbar for Adaptive Synchronization

Nonlinear circuits may be synchronized with interconnections that evolve in time incorporating mechanisms of adaptation found in many biological systems. Such dynamics in the links is efficiently implemented in electronic devices by using memristors. However, the approach requires a massive amount of interconnections (of the order of <inline-formula> <tex-math notation="LaTeX">$N^{2}$ </tex-math></inline-formula>, where <inline-formula> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> is the number of nonlinear circuits to be synchronized). This issue is solved in this paper by adopting a memristor crossbar architecture for adaptive synchronization. The functionality of the structure is demonstrated, with respect to different switching characteristics, via a simulation-based evaluation using a behavioral threshold-type model of voltage-controlled bipolar memristor. In addition, we show that the architecture is robust to device variability and faults: quite surprisingly, when faults are localized, the performance of the approach may also improve as adaptation becomes more significant.
Reproducibility of forced expiratory flow and volume measurements in infants with bronchiolitis

The end‐tidal rapid thoracoabdominal compression (ETRTC) technique is an established method for lung function testing in infancy. Previous work in healthy infants, however, has shown that measurements with the newly developed raised volume rapid thoracoabdominal compression (RVRTC) technique are more reproducible than those with the ETRTC technique. So far, reproducibility of the two techniques has not been compared in infants with acute airway disease. Twenty‐three infants with acute viral bronchiolitis underwent lung function assessment with both the ETRTC and the RVRTC technique. A series of 8–10 measurements with each technique was done in randomized order. Forced expired volumes at 0.5, 0.75, and 1 sec after chest compression (FEV0.5, FEV0.75, and FEV1.0) were measured with the RVRTC technique; maximum expiratory flow at functional residual capacity (V′maxFRC) was measured with the ETRTC technique. Group mean intrasubject coefficients of variation (CV) were 4.84% for FEV0.5, 5.01% for FEV0.75, 5.43% for FEV1.0, and 13.79% for V′maxFRC, respectively.
Average Consensus Over High-Order Multiagent Systems

This technical note considers the consensus problem in high-order multiagent systems under undirected networks. By employing agents relative positions, sufficient conditions are proposed under which the agents reach agreement on a common position while their higher-order states converge to zero. Despite introduced consensus protocols in the literature for high-order systems, by using only relative positions, it is possible to achieve consensus on the average of any shared quantities of the agents. By setting the shared quantities properly, the obtained protocol is employed to achieve consensus on the average of the initial positions of the agents. Numerical examples confirm the accuracy of the proposed consensus protocol.
Anaphase Catastrophe Is a Target for Cancer Therapy

Neoplastic cells are genetically unstable. Strategies that target pathways affecting genome instability can be exploited to disrupt tumor cell growth, potentially with limited consequences to normal cells. Chromosomal instability (CIN) is one type of genome instability characterized by mitotic defects that increase the rate of chromosome mis-segregation. CIN is frequently caused by extra centrosomes that transiently disrupt normal bipolar spindle geometry needed for accurate chromosome segregation. Tumor cells survive with extra centrosomes because of biochemical pathways that cluster centrosomes and promote chromosome segregation on bipolar spindles. Recent work shows that targeted inhibition of these pathways prevents centrosome clustering and forces chromosomes to segregate to multiple daughter cells, an event triggering apoptosis that we refer to as anaphase catastrophe. Anaphase catastrophe specifically kills tumor cells with more than 2 centrosomes. This death program can occur after genetic or pharmacologic inhibition of cyclin dependent kinase 2 (Cdk2) and is augmented by combined treatment with a microtubule inhibitor. This proapoptotic effect occurs despite the presence of ras mutations in cancer cells. Anaphase catastrophe is a previously unrecognized mechanism that can be pharmacologically induced for apoptotic death of cancer cells and is, therefore, appealing to engage for cancer therapy and prevention. Clin Cancer Res; 17(6); 1218–22. ©2011 AACR.
Risk factors for renal allograft survival from pediatric cadaver donors: an analysis of united network for organ sharing data.

BACKGROUND The shortage of cadaveric donors for kidney transplantation has prompted many centers to use cadaver kidneys from pediatric donors. Use of kidneys from pediatric donors has been shown to have a lower graft survival. METHODS Recipients receiving cadaver kidneys from pediatric and adult donors between 1988 and 1995 were analyzed. The data were obtained from United Network of Organ Sharing database. The actuarial kidney transplant graft survival was estimated by the Kaplan-Meier method. A logistic regression analysis was used to identify various risk factors for 1-year graft failure. Odds ratios (OR) were estimated for various risk factors. RESULTS Kidney transplant survival rates for donor age <18 years (n=12,838) at 1, 2, 3, 4, and 5 years were 81.5%, 76.3%, 71.3%, 66.4%, and 61.7%, respectively. The corresponding results for adult donors from age 18 to 50 years (n=35, 442) were 83.5%, 78.4%, 73.1%, 67.9%, and 62.4%, respectively, Log-rank test P<0.01. Pediatric donors were further divided into three groups according to donor age: group I (0-5 years), group II (6-11 years), and group III (12-17 years). The actuarial survival rates for 1, 3, and 5 years for group I (n=2198) were 73.6%, 63.3%, and 55.6%, respectively. The corresponding values for group II (n=2873) were 78.0%, 67.5%, and 57.8% and for group III (n=7767) were 85%, 75.0%, and 64.8%, respectively, P<0.01. Although the recipients of group I had lower graft survival, en bloc grafts (n=751) had much better 1-, 3-, and 5-year graft survival rates (76.3%, 67.7%, and 60.7%, respectively) compared with single grafts (n=1447; 72.2%, 61.1%, and 53.2%, P=0.02) from donors 0 to 5 years. Graft thrombosis as a cause of graft failure was seen in 10% of group I compared with 6% in group II and 5% in group III. In group I, lower OR were seen when an en bloc transplant was performed (0.688, P<0.01) and when donor body weight was>15 kg (0.547, P<0.01). However, OR were elevated in recipients of previous transplants (1.556, P<0.01), with prolonged cold ischemic time (1.097, P=0.03), for black recipients (1.288, P=0.03), and for recipients with body mass index> or =25 (1.286, P=0.02). Progressive increase in the donor age was associated with lower OR in group II (0.894, P<0.01). CONCLUSIONS (1) Overall, poorer graft survival was seen in pediatric donor transplants, (2) transplant kidney survival with en bloc kidneys was better than a single kidney from donors 0-5 years, (3) progressive increase in donor age was associated with improved graft survival when the donors were 6-11 years, whereas progressive increase in donor weight was associated with improved graft survival when the donors were 0-5 years.
Transformation of conventional T cells into regulatory T cells in children with metabolic syndrome.

BACKGROUND Much research has been done in the recent years to establish an association between obesity, metabolic syndrome and the immune system. Numerous data suggest that the decreased number and/or function of regulatory T cells (Treg cells) can lead to chronic minimal inflammation present in patients with obesity and trigger formation of atherosclerotic plaque. AIM To generate Treg cells from the peripheral blood in children meeting the diagnostic criteria of metabolic syndrome. METHODS A total of 25 children with metabolic syndrome and 25 controls were enrolled in the study. Peripheral blood was collected, CD4(+)/CD25(-) cells were separated and cultured for 4 weeks in the presence of a Treg expander (CD3/CD28) and interleukin-2. The expression of the transcription factor FoxP3 as a Treg marker was assessed before and after culture using reverse transcriptase polymerase chain reaction (RT-PCR) and flow cytometry. RESULTS Before the culture we observed a slightly lower percentage of Treg cells in children with metabolic syndrome vs controls. After the culture we noted a significant increase in mRNA expression and in the percentage of FoxP3-positive cells. We observed no differences in the results between the children with metabolic syndrome and the controls. CONCLUSIONS Our study shows that it is possible to generate Treg cells from peripheral blood of children with metabolic syndrome. In future, these findings could be used to develop a model of immunotherapeutic intervention for patients at risk of cardiovascular disease.
Enhanced Thermal Efficiency in Phase-Change Memory Cell by Double GST Thermally Confined Structure

A novel phase-change memory cell with a double- confinement structure was proposed and fabricated in this work. By having an additional bottom Ge2Sb2Te5 layer under the electrically confined active region, the heat loss can be effectively prevented. The temperature uniformity over the active region significantly improves and so does the thermal efficiency. Therefore, a low IRESET of about 0.3 mA and a reset power can be achieved. For the SET performance, a pulsewidth as low as 200 ns can be used without compromising the RSET.
The role of opioid processes in reward and decision‐making

Contemporary theories emphasize the involvement of the endogenous opioid system in assigning hedonic values to rewards. Although earlier research supports this view, recent findings suggest that opioids play a larger and more complex role in reward processes than these theories suggest. For example, opioid activity in the basolateral amygdala is required for encoding incentive learning, a process by which the value of goal‐directed actions is updated. Outside the amygdala, opioid receptors in the ventral striatum have been found to promote choice between different courses of action. Specifically, μ opioid receptors in the nucleus accumbens core and δ opioid receptors in the nucleus accumbens shell have been reported to mediate distinct aspects of incentive motivation; the core regulating the effect of experienced reward and the shell of predicted reward on choice. In both cases, the involvement of opioid receptors was restricted to the time of choice, although changes in their expression pattern could be observed prior to that point. This time‐restricted involvement of opioid receptor‐related processes is consistent with the view that opioids in the nucleus accumbens are central components of the limbic‐motor interface, integrating reward‐related information with instrumental learning to guide decision‐making, particularly the selection and execution of goal‐directed actions.