Miracle-dz/UniFAR-FTUs huggingface dataset:
SECRETORY IMMUNOGLOBULIN A (SIGA) AND DENTAL CARIES OF CHILDREN WITH DIFFERENT DISEASES AND CONDITIONS INFLUENCING ORAL MEDIUM

SUMMARY SIgA is the main type immunoglobulin in the mixed saliva and is considered as the main secretion factor of the adaptive immunity in the mouth. The purpose of the study is an evaluation of the SIgA quantities and the connection of those antibodies with dental caries of children with different diseases and conditions influencing the oral medium. The study was performed with 116 children with diabetes, asthma, orthodontic problems (removable braces) and healthy controls. The following methods were used: (1) ELISA with “Salivary secretory IgA KIT of Salimetrics LLC USA; was used for quantitative determination of IgAS in the saliva ;(2) Evaluation of the liquid oral medium (test “Saliva check-GC”) and dental status (DMF-T) of the children studied. The results obtained came to show that 2/3 of the healthy children and the children with diabetes have low values of c( 300 µg/ml); There is no dependence between secretory immunity and dental caries in children.
Efficacy of iloperidone in the short‐term treatment of schizophrenia: a post hoc analysis of pooled patient data from four phase III, placebo‐ and active‐controlled trials

The efficacy and tolerability characteristics of an antipsychotic are difficult to determine from a single registration study. We thus conducted an analysis that assessed key efficacy and tolerability outcomes post hoc from four pooled short‐term (4–6 weeks) phase III studies that evaluated iloperidone versus placebo in patients with schizophrenia or schizoaffective disorder.
Transverse dynamical magnetic susceptibilities from regular static density functional theory: Evaluation of damping and g shifts of spin excitations

The dynamical transverse magnetic Kohn-Sham susceptibility calculated within time-dependent density functional theory shows a fairly linear behavior for a finite energy window. This observation is used to propose a scheme where the computation of this quantity is greatly simplified. Regular simulations based on static density functional theory can be used to extract the dynamical behavior of the magnetic response function. Besides the ability to calculate elegantly damping of magnetic excitations due to electron-hole excitations, we derive along the way useful equations giving the main characteristics of these excitations: effective $g$ factors and the resonance frequencies that can be accessed experimentally using inelastic scanning tunneling spectroscopy or spin-polarized electron energy loss spectroscopy.
A Multistage System for the Automated Detection of Epileptic Seizures in Neonatal Electroencephalography

This paper describes the design and test results of a three-stage automated system for neonatal EEG seizure detection. Stage I of the system is the initial detection stage and identifies overlapping 5-second segments of suspected seizure activity in each EEG channel. In stage II, the detected segments from stage I are spatiotemporally clustered to produce multichannel candidate seizures. In stage III, the candidate seizures are processed further using measures of quality and context-based rules to eliminate false candidates. False candidates because of artifacts and commonly occurring EEG background patterns such as bifrontal delta activity are also rejected. Seizures at least 10 seconds in duration are considered for reporting results. The testing data consisted of recordings of 28 seizure subjects (34 hours of data) and 48 nonseizure subjects (87 hours of data) obtained in the neonatal intensive care unit. The data were not edited to remove artifacts and were identical in every way to data normally processed visually. The system was able to detect seizures of widely varying morphology with an average detection sensitivity of almost 80% and a subject sensitivity of 96%, in comparison with a team of clinical neurophysiologists who had scored the same recordings. The average false detection rate obtained in nonseizure subjects was 0.74 per hour.
Preventable harm occurring to critically ill children*

Objective: To develop a trigger tool for identifying adverse events occurring in critically ill pediatric patients; to identify and characterize adverse events and preventable adverse events experienced by critically ill pediatric patients; and to characterize the patients who experience preventable adverse events. Design: Retrospective chart review using a trigger tool. Setting: Pediatric intensive care unit of a tertiary, university-affiliated pediatric hospital. Patients: A systematic sample of 259 pediatric intensive care unit patients from a 1-yr period. Interventions: None. Measurements and Main Results: We measured frequency of occurrence (0.19 preventable adverse events per patient-day), severity of harm (78% minor, 19% moderate, 3% serious, no deaths), and type of event (sedation, 22%; skin, 16%; medical device complication, 14%; pulmonary, 13%; and cardiovascular, 11%). Patients who experienced preventable adverse events were younger, had longer lengths of stay, and had higher illness burdens. Preventable adverse events occurred more frequently among surgical patients than medical patients. Conclusions: Preventable adverse events occurred fairly frequently in the pediatric intensive care unit, but serious harm was rare. Conditions that increased the likelihood of a preventable adverse event were a) need for sedation or pain control; b) relative immobility; and c) need for vascular devices, feeding tubes, or ventilators. Adverse event prevention strategies that focus on improving patient monitoring under increased-risk conditions and improving early detection and treatment of potential harm will likely be more effective than strategies aimed at general error prevention.
Can typical US home visits affect infant attachment? Preliminary findings from a randomized trial of Healthy Families Durham

ABSTRACT US government-funded early home visiting services are expanding significantly. The most widely implemented home visiting models target at-risk new mothers and their infants. Such home visiting programs typically aim to support infant–parent relationships; yet, such programs’ effects on infant attachment quality per se are as yet untested. Given these programs’ aims, and the crucial role of early attachments in human development, it is important to understand attachment processes in home visited families. The current, preliminary study examined 94 high-risk mother–infant dyads participating in a randomized evaluation of the Healthy Families Durham (HFD) home visiting program. We tested (a) infant attachment security and disorganization as predictors of toddler behavior problems and (b) program effects on attachment security and disorganization. We found that (a) infant attachment disorganization (but not security) predicted toddler behavior problems and (b) participation in HFD did not significantly affect infant attachment security or disorganization. Findings are discussed in terms of the potential for attachment-specific interventions to enhance the typical array of home visiting services.
Using Pro-Environmental Information to Modify Conservation Behavior: Paper Recycling and Reuse

In cases where market policy instruments (e.g., taxes and quotas) are impractical tools to induce conservation behavior, information campaigns may be a valuable option. We use a difference-in-differences strategy to estimate the effectiveness a signage campaign for inducing paper recycling and reuse behavior in computer labs. We find that the implementation of signage with pro-environment appeals increases the probability of conservation behavior (i.e., recycling or reuse) by approximately 13%, despite the fact that pre-treatment levels of paper recycling and reuse were already at approximately 85%. Our results suggest that pro-environment campaigns can be an effective conservation tool and may be an important policy instrument for policy makers to consider.
In vitro antiviral drug sensitivity of the Kaposi's sarcoma‐associated herpesvirus

Objective:Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, has been implicated as the causative agent of Kaposi's sarcoma. Retrospective studies show that the risk of development of Kaposi's sarcoma is significantly lower in AIDS patients who received ganciclovir or phosphonoformic acid (PFA) therapy. Therefore, in vitro antiviral drug sensitivity of KSHV was studied. Methods:The KSHV genome is a latent episome in lymphoma cells such as the BCBL-1 cell line. Lytic KSHV DNA synthesis is induced by the phorbol ester 12-O-tetradecanoyl phorbol-13-acetate in BCBL-1 cells; this system was used to evaluate the effects of antiviral drugs on KSHV DNA synthesis. Results:Linear (lytic) KSHV DNA synthesis and virus secretion was inhibited in BCBL-1 cell cultures by cidofovir (median inhibitory concentration, 0.05 µM), ganciclovir (5.1 µM) and PFA (97 µM), and by aciclovir (75 µM). Prolonged incubation of BCBL-1 cells with antiviral drugs had no effect on episomal KSHV DNA synthesis. Conclusions:The antiviral drug assay developed shows that KSHV is very sensitive to cidofovir, moderately sensitive to ganciclovir and PFA, and weakly sensitive to aciclovir. Therefore, low doses of cidofovir, or high doses of PFA or ganciclovir could suppress clinical reactivation of KSHV. Antiviral drugs did not inhibit episomal virus DNA synthesis, suggesting that the latent form of viral DNA is replicated by host DNA polymerases. Consequently, no benefit can be expected from antiviral drugs in KSHV-positive B-cell lymphomas or during latency.
Analysis of the Modulation Strategy for the Minimization of the Leakage Current in the PV Grid-Connected Cascaded Multilevel Inverter

This paper presents a pulse width modulation (PWM) technique for the minimization of the leakage current in the grid-connected/stand-alone transformerless photovoltaic (PV)-cascaded multilevel inverter (CMLI). The proposed PWM technique is integrated with the MPPT algorithm and is applied to the five-level CMLI. Furthermore, using the proposed PWM technique the high-frequency voltage transitions in the terminal and common mode voltages are minimized. Thus, the proposed PWM technique minimizes the leakage current of the PV array and electromagnetic interference filter requirement in the system without addition of any extra switches. Furthermore, this paper also presents the analysis for the terminal voltage across the PV array and the common mode voltage of the inverter based on the switching function. Using the given analysis, the effect of the PWM technique can be analyzed, as it directly links the switching function with the common mode voltage and leakage current. Also, the proposed PWM technique requires reduced number of carrier waves compared to the conventional sinusoidal pulse width modulation technique for the given CMLI. Complete details of the working principle and analysis with the support of simulation and experimental results of the proposed PWM technique are presented in this paper.
The Success of Anterior Cervical Arthrodesis Adjacent to a Previous Fusion

Study Design. A retrospective review of all patients surgically treated for adjacent segment disease of the cervical spine over a 20‐year period. Objectives. To determine the clinical and radiographic success of discectomy with interbody grafting and corpectomy with strut grafting in the treatment of adjacent segment disease of the cervical spine. Summary of Background Data. Up to 25% of all patients undergoing anterior cervical fusion have new disease due to degeneration of an adjacent segment within 10 years. The success of surgical treatment in these patients with adjacent segment disease has not been reported. Methods. Thirty‐eight patients were surgically treated for adjacent segment disease by discectomy with interbody grafting or corpectomy with strut grafting. Arthrodesis was evaluated by flexion‐extension lateral radiographs and clinical outcomes were assessed using Robinson's criteria at least 2 years after surgery. Fusion rates were compared by Fisher's exact test, and outcomes were compared by rank‐sum analysis. Results. The rate of arthrodesis was significantly lower in the 24 patients treated by discectomy with interbody grafting at one or more levels (63%) than in the 14 patients treated by corpectomy with strut grafting (100%; P = 0.01). Clinical outcomes were similar for the corpectomy and discectomy groups (P = 0.55). There was a trend toward better outcomes in patients who achieved a solid arthrodesis (P = 0.13). Conclusions. Achieving fusion is more difficult when anterior cervical arthrodesis is performed adjacent to a prior fusion. Strut grafting resulted in a significantly higher rate of arthrodesis than interbody grafting.
Outcomes of mechanical stapling for postlaryngectomy open pharyngotomy closure

A total laryngectomy (TL) is performed as a primary or salvage therapy for laryngeal carcinoma. Pharyngotomy closure after TL is typically performed using manual sutures. Automatic stapling devices are routinely used in thoracoabdominal surgery, but have not been widely accepted for use in pharyngotomy closure. Previously described closed stapling techniques of pharyngeal closure do not allow direct evaluation of surgical margins and are limited to endolaryngeal disease. We describe an open technique for pharyngotomy closure using a mechanical stapling device.
The relationship between cannabis and violence: a review.

This review critically examines the evidence dealing with the alleged relationship between cannabis and violence and considers some of the variables that enter into such an assessment. The consensus is that marijuana does not precipitate violence in the majority of those using it sporadically or chronically. However, there are certain individuals, such as those suffering from temporal lobe dysrhythmia, and certain situations of set and setting, in which marijuana may result in violence.
Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution

Significance Antigen presentation genes are exceptionally polymorphic, enhancing immune defense. Polymorphism within additional components of the MHC pathway, particularly the antigen processing genes, may also shape immune responses. Using transcriptome, exome, and whole-genome sequencing to examine immune gene variation in zebrafish, we uncovered several antigen processing genes not found in the reference genome clustered within a deeply divergent haplotype of the core MHC locus. Our data provide evidence that these previously undescribed antigen processing genes retain ancient alternative sequence lineages, likely derived during the formation of the adaptive immune system, and represent the most divergent collection of antigen processing and presentation genes yet identified. These findings offer insights into the evolution of vertebrate adaptive immunity. Antigen processing and presentation genes found within the MHC are among the most highly polymorphic genes of vertebrate genomes, providing populations with diverse immune responses to a wide array of pathogens. Here, we describe transcriptome, exome, and whole-genome sequencing of clonal zebrafish, uncovering the most extensive diversity within the antigen processing and presentation genes of any species yet examined. Our CG2 clonal zebrafish assembly provides genomic context within a remarkably divergent haplotype of the core MHC region on chromosome 19 for six expressed genes not found in the zebrafish reference genome: mhc1uga, proteasome-β 9b (psmb9b), psmb8f, and previously unknown genes psmb13b, tap2d, and tap2e. We identify ancient lineages for Psmb13 within a proteasome branch previously thought to be monomorphic and provide evidence of substantial lineage diversity within each of three major trifurcations of catalytic-type proteasome subunits in vertebrates: Psmb5/Psmb8/Psmb11, Psmb6/Psmb9/Psmb12, and Psmb7/Psmb10/Psmb13. Strikingly, nearby tap2 and MHC class I genes also retain ancient sequence lineages, indicating that alternative lineages may have been preserved throughout the entire MHC pathway since early diversification of the adaptive immune system ∼500 Mya. Furthermore, polymorphisms within the three MHC pathway steps (antigen cleavage, transport, and presentation) are each predicted to alter peptide specificity. Lastly, comparative analysis shows that antigen processing gene diversity is far more extensive than previously realized (with ancient coelacanth psmb8 lineages, shark psmb13, and tap2t and psmb10 outside the teleost MHC), implying distinct immune functions and conserved roles in shaping MHC pathway evolution throughout vertebrates.
Prolactin Levels after Bilateral and Unilateral ECT

Summary Serial post-ictal serum prolactin levels were obtained over a period of one hour after bilateral or unilateral electroconvulsive therapy (ECT) in six patients. Bilateral ECT yielded significantly higher mean post-ictal prolactin levels than unilateral ECT at the 15,20,30 and 60 minute sampling times. These findings demonstrate a greater hypothalamic-stimulating effect of bilateral than unilateral ECT, and may explain the reported therapeutic advantage of bilateral over unilateral ECT in the treatment of patients with melancholia.
A CyberOrganism model for awareness in collaborative communities on the Internet

The Internet/World Wide Web has grown very rapidly to become a major resource supporting collaborative activities in a wide range of groups, disciplines, and communities. However, the growth of the net/web creates problems of information overload and of maintaining awareness of activities at other sites relevant to one's own tasks. This article discusses awareness issues in collaborative group; develops a conceptual framework for studying and supporting awareness on the web; describes CHRONO, a tool for supporting awareness of changes at another site. Finally a preliminary sketch of an overall conceptual framework for the Internet is presented and explored. This CyberOrganism framework is used to analyze and classify chronological awareness support systems and general communication systems that support awareness maintenance on the Internet. © 1997 John Wiley & Sons, Inc.
Cordycepin induces apoptosis in human bladder cancer cells via activation of A3 adenosine receptors

Bladder cancer is a neoplasm originated from bladder epithelial cells. The therapy for bladder cancer is so far not satisfactory. In this study, we examined the effects of Cordyceps militaris hot water extracts containing cordycepin on human bladder cells. Cordyceps militaris hot water extracts containing cordycepin was used to treat human T24 bladder carcinoma cells, and we found that Cordyceps militaris hot water extracts containing cordycepin decreased T24 cell survival in a dose-dependent manner, which was seemingly mediated by activation of A3 adenosine receptor and the subsequent inactivation of Akt pathways, resulting in increases in cleaved Caspase-3 and apoptosis. Overexpression of A3 adenosine receptor in T24 cells mimicked the effects of Cordyceps militaris hot water extracts, while A3 adenosine receptor depletion abolished the effects of Cordyceps militaris hot water extracts containing cordycepin. Together, these data suggest that Cordyceps militaris hot water extracts containing cordycepin may be a promising treatment for bladder cancer via A3 adenosine receptor activation.
Exploring the Ubiquinone Binding Cavity of Respiratory Complex I*

Proton pumping respiratory complex I is a major player in mitochondrial energy conversion. Yet little is known about the molecular mechanism of this large membrane protein complex. Understanding the details of ubiquinone reduction will be prerequisite for elucidating this mechanism. Based on a recently published partial structure of the bacterial enzyme, we scanned the proposed ubiquinone binding cavity of complex I by site-directed mutagenesis in the strictly aerobic yeast Yarrowia lipolytica. The observed changes in catalytic activity and inhibitor sensitivity followed a consistent pattern and allowed us to define three functionally important regions near the ubiquinone-reducing iron-sulfur cluster N2. We identified a likely entry path for the substrate ubiquinone and defined a region involved in inhibitor binding within the cavity. Finally, we were able to highlight a functionally critical structural motif in the active site that consisted of Tyr-144 in the 49-kDa subunit, surrounded by three conserved hydrophobic residues.
Posttraumatic Stress Disorder in Posttransplant Children: Creating a Clinical Program to Address Their Needs

Abstract Posttraumatic stress symptoms have been shown to occur in pediatric and adult solid-organ transplant recipients. The presence of these symptoms is associated with non-adherence to medications, increased distress, and poor outcome. Because posttraumatic stress disorder is treatable and because a transplant operation usually is an “anticipated trauma,” it is possible to address posttraumatic stress disorder symptoms in transplant recipients and attempt to prevent their development. Under my direction, the pediatric liver transplant program at Mount Sinai Medical Center in NewYork City created research and clinical programs to address posttraumatic stress symptoms and their consequences. Specifically, the focus on non-adherence to immunosuppressive medications in transplant recipients who are distressed and their parents. This article begins with a review of the data that led to the decision to start these programs. I then present the basic elements that are in place, in this particular program, to address patients' needs. I end this review with preliminary outcome data that illustrate the potential impact of such an integrated approach to patient care on medical outcomes.
The Use of Diclofenac Sodium (Voltaren®) Suppositories as an Antipyretic in Children with Fever Due to Acute Infections: A Double-Blind, Between-Patient, Placebo-Controlled Study

In a placebo-controlled double-blind, between-patient trial the antipyretic effect of diclofenac sodium (Voltaren®) was studied in forty-three children ranging from 2–10 years of age. All patients were hospitalized because of acute illness associated with fever (38.5° C-40.4° C; mean 39.3° C) due to viral or bacterial infections. The trial medication was given in the form of suppositories containing 25 mg of diclofenac sodium or as matching placebo to children aged from 2–5 years. The children aged from 6–10 years received a 50 mg diclofenac sodium suppository or placebo. Body temperature and pulse rate were measured at the time of administration and after 1/2, 1, 2, 4 and 6 hours. The results showed a return to normal temperature values after 2 hours in all patients receiving diclofenac sodium, whereas in the placebo group only minimal changes were observed. No unwanted effects were reported.
Pattern-Reconfigurable Dual-Polarized Dielectric Resonator Antenna

We present a portable pattern-reconfigurable dual-polarized dielectric resonator antenna (DRA). Low-cost gallium arsenide (GaAs) single-pole, double-throw (SPDT) switches are utilized to select one of the feedline paths of the DRA, giving a boresight or cardioid pattern electronically. The measured results verify the proposed antenna switches its radiation patterns between cardioid and boresight shape, without significantly affecting its matching in the operating frequency range of 5-6 GHz. Results also confirm that the pattern configuration in one port with one polarization does not affect the RF characteristics of the other port with alternative polarization of the antenna. This two-port configuration makes the proposed antenna a suitable candidate for IEEE 802.11ac multi-user multiple-input-multiple-output (MU-MIMO) applications.