Miracle-dz/UniFAR-FTUs huggingface dataset:
Problems Experienced by the Informal Caregivers of Cancer Patients and Their Needs for Support

Informal caregivers experience problems of their own for which they need support, but despite the efforts of the World Health Organization to include the well-being of family members and caregivers in the concept of palliative care, their needs are rarely assessed systematically. This report explores caregivers' problems and their needs for professional support. Seventy-six caregivers of cancer patients with advanced disease completed a comprehensive needs assessment questionnaire, the Problems and Needs in Palliative Care questionnaire-caregiver form, listing 67 potential problems in their quality of life and their role of caregiver and 9 items concerning informational needs. The results of this study reveal that the "Top 20" list of the problems and needs reported by caregivers includes fears and emotional burdens; for the most part, caregivers did not need any more professional attention than they were already receiving. Many, however, needed support for managing patients' symptoms and wanted professional attention for the availability and coordination of services. Despite communalities, there was diversity in caregivers' individual needs. Personal needs could be identified with the Problems and Needs in Palliative Care questionnaire-caregiver form checklist. Although only a few caregivers were affected by some issues, such as financial problems, help for them was often needed. In conclusion, most caregivers would like more professional attention for 4 or 5 specific issues, often related to their competence as caregivers for their patients. Using structured needs assessments with the Problems and Needs in Palliative Care questionnaire-caregiver form seems a feasible method to identify the needs of individual caregivers in palliative care.
Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila

Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in both model organisms. Mitochondrial function and ultrastructure are maintained in mouse heart, whereas subpopulations of mitochondria from mouse liver show age-related changes in membrane morphology. Subpopulations of mitochondria from young and old mouse kidney resemble those described for apoptosis. In aged flies, respiratory activity is compromised and the production of peroxide radicals is increased. In about 50% of mitochondria from old flies, the inner membrane organization breaks down. This establishes a clear link between inner membrane architecture and functional decline. Mitochondria were affected by ageing to very different extents, depending on the organism and possibly on the degree to which tissues within the same organism are protected against mitochondrial damage. DOI: http://dx.doi. org/10.7554/eLife.24662. 001
The role of technological capabilities in the internationalization of R&D intensive SMEs

Addresses a crucial issue which is central to technology management since it focuses on the role of R&D-related capabilities as determinants of export performance. Empirical evidence from 202 R&D-intensive small and medium-sized enterprises (SMEs) indicates that the more advanced stages of internationalization require broader, more aggressive and externally-oriented R&D capabilities. The results suggest that more advanced exporters tap in to specialized skills and gain knowledge from different foreign environments. During the internationalization process, organizational learning occurs, more advanced and specialized skills are sought, and firms become more knowledge-intensive.
The calorigenic response of cold-acclimated white rats to infused noradrenaline.

The increase in oxygen consumption during continuous intravenous injection of various doses of L-noradrenaline was measured in anesthetized rats fully acclimated to 6 °C. The metabolic response was found to be linearly related to the logarithm of the amount of noradrenaline infused per minute. The calorigenic response to infusion of noradrenaline at a level of 1 μg per minute was then measured in rats undergoing acclimation to cold. The calorigenic response was found to increase with time of exposure to the cold environment, thus paralleling previous observations in the time course of gain in cold resistance, increase in food consumption, and loss of dependence on shivering during acclimation of white rats to cold. Also, the same maximal increase in oxygen consumption was obtained on infusion of noradrenaline into functionally eviscerated and sham-operated cold-acclimated rats, thus indicating that the liver and other abdominal viscera (kidneys excluded) are not involved in the calorigenic response to nor.
Study of the analgesic effect of lanepitant in patients with osteoarthritis pain

Lanepitant selectively blocks substance P binding to the neurokinin‐1 receptor, preventing neurogenic inflammation and pain transmission. Substance P is present in synovial fluid and in excess in cerebral spinal fluid. We investigated the effect of lanepitant on pain caused by osteoarthritis to evaluate the role of neurokinin‐1 blockade.
Prices and Heterogeneous Search Costs

We study price formation in a model of consumer search for differentiated products when consumers have heterogeneous marginal search costs. We provide conditions under which a symmetric Nash equilibrium exists and is unique. Search costs affect two margins—the intensive search margin (or search intensity) and the extensive search margin (or the decision to search rather than to not search at all). These two margins affect the elasticity of demand in opposite directions and whether lower search costs result in higher or lower prices depends on the properties of the search cost density. When the search cost density has the increasing likelihood ratio property (ILRP), the effect of lowering search costs on the intensive search margin has a dominating influence and prices decrease. By contrast, when the search cost density has the decreasing likelihood ratio property (DLRP), the effect on the extensive search margin is dominant and lower search costs result in higher prices. We compare these results with those obtained when consumers have heterogeneous fixed search costs.
Assessment of decision-making performance and in-game physical exertion of Australian football umpires

Abstract The aim of this study is to investigate the effects of in-game physical exertion on decision-making performance of Australian football umpires. Fifteen Australian football umpires (Mage = 36, s = 13.5 years; Mgames umpired = 235.2, s = 151.3) volunteered to participate in the study. During five competitive Australian football pre-season games, measures of in-game physical exertion (blood lactate levels, global positioning system [GPS]) and decision-making performance (video-based test) were obtained. There were no significant correlations between physical exertion in a particular quarter and decision-making performance in either the same quarter or any other quarter. Video-based decision-making performance was effected by time in game χ2(3) = 24.24, P = 0.001, with Quarter 4 performance significantly better than both Quarter 2 and Quarter 3. In-game physical exertion (blood lactate) significantly decreased over the course of the game χ2(3) = 11.58, P = 0.009. Results indicate no definable link between in-game physical exertion and decision-making performance. It is, however, presumed that decision-making performance may be affected by the time or context of the game. Future research is warranted to explore the relationship between physical exertion and decision-making performance to potentially inform Australian football umpire training programmes that replicate in-game physical and decision-making demands.
Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types

SOX family proteins SOX2 and SOX18 have been reported as being essential in determining hair follicle type; however, the role they play during development remains unclear. Here, we demonstrate that Sox18 regulates the normal differentiation of the dermal papilla of all hair types. In guard (primary) hair dermal condensate (DC) cells, we identified transient Sox18 in addition to SOX2 expression at E14.5, which allowed fate tracing of primary DC cells until birth. Similarly, expression of Sox18 was detected in the DC cells of secondary hairs at E16.5 and in tertiary hair at E18.5. Dominant-negative Sox18 mutation (opposum) did not prevent DC formation in any hair type. However, it affected dermal papilla differentiation, restricting hair formation especially in secondary and tertiary hairs. This Sox18 mutation also prevented neonatal dermal cells or dermal papilla spheres from inducing hair in regeneration assays. Microarray expression studies identified WNT5A and TNC as potential downstream effectors of SOX18 that are important for epidermal WNT signalling. In conclusion, SOX18 acts as a mesenchymal molecular switch necessary for the formation and function of the dermal papilla in all hair types. Summary: The Sox18Op/+ mutation in mice, which mimics a hair loss condition in humans, leads to decreasing Wnt signal interactions with the hair follicle epidermis and abnormal hair follicle morphology.
Inflammatory Properties of IgG Modified by Oxygen Radicals and Peroxynitrite1

In inflammatory arthritis, there is evidence indicating that the affected tissues produce large amounts of oxygen-free radicals and NO. Herein, we examine the biologic effects of exposure of IgG to hypochlorous acid (HOCl) and peroxynitrite (ONOO). The concentrations of IgG modified by chlorination and nitrosation were measured in synovial fluids from inflammatory and noninflammatory arthritis. Human IgG was exposed to increasing concentrations of HOCl and ONOO, and the resulting products were tested for complement component binding; binding to FcγRI; activation of polymorphonuclear neutrophils; effect on the Ab-combining site of Abs; and in vivo inflammatory activity in a rabbit model of acute arthritis. Rheumatoid synovial fluids contained significantly greater concentrations of nitrosated and chlorinated IgG compared with ostearthritic specimens. In vitro exposure of human IgG to HOCl and ONOO resulted in a concentration-dependent decrease in C3 and C1q fixation. The decrease in Fc domain-dependent biologic functions was confirmed by competitive binding studies to the FcγRI of U937 cells. HOCl-treated IgG monomer was 10 times less effective in competing for binding compared with native IgG, and ONOO-treated IgG was 2.5 times less effective. The modified IgGs were also ineffective in inducing synthesis of H2O2 by human PMN. The Ag-binding domains of IgG also showed a concentration-dependent decrease in binding to Ag. The ability of the modified IgGs to induce acute inflammation in rabbit knees decreased 20-fold as gauged by the intensity of the inflammatory cell exudates. These studies clarify the modulating role of biological oxidants in inflammatory processes in which Ag-autoantibody reactions and immune complex pathogenesis may play an important role.
MYOCARDIAL INFARCTION IN A HORSE WITH COLIC - CLINICAL, LABORATORY AND PATHOMORPHOLOGICAL FINDINGS

A clinical case of a horse with colic due to large intestinal meteorism and secondary proximal enteritis is reported. The physical examination revealed signs of endotoxaemia (cyanotic mucosae with petechiae and a toxic line), fever, polypnea, tachycardia and pulse deficit. The haematological results indicated haemoconcentration with marked leukopaenia, neutropaenia and a left shift. Blood biochemistry demonstrated changes in blood electrolytes, muscle enzymes, glucose, creatinine, urea and very high levels of serum cardiac troponin I. Electrocardiography findings consisted in premature ventricular complexes and ventricular tachycardia. Cardiac ultrasound did not show any structural changes. Myocardial infarctions were observed post mortem.
Measurement of Audible Noise from Transmission Lines

The audible noise produced by corona on high-voltage transmission iines has several characteristics which differentiate it from other more often encountered community noises, and which warrant a specialized document describing techniques for the measurement of transmission-line noise. This document covers the general characteristics of ac and dc transmission-line noise, instrumentation for its measurement, measuring and reporting procedures, and precautions in measurement.
The Septuagint as Jewish-Hellenistic Writing?

ABSTRACT Scholars have different views as to what should be regarded as the essence of the Septuagint. Martin Hengel argued that “all Judaism from the 2nd century BCE should be deemed as Hellenistic Judaism”. Sylvie Honigman came up with the suggestion that, inter alia, the Septuagint should be seen as Alexandrian literature. Taking the true essence of the LXX into account, it is the intention of this paper to demonstrate that the Septuagint should rather be taken as a JEWISH-Hellenistic writing. The paper evaluates the above-mentioned claims. It deals with the uncritical tendency of scholars to accept that the claim of the Aristeas book, which refers only to the Pentateuch, that the original Septuagint came to be in Alexandria is also applicable to the rest of the corpus of Septuagintal books.
Association between tumour necrosis factor-alpha G-308A polymorphism and risk of nephropathy in obese Chinese type 2 diabetic patients.

BACKGROUND The G-308A polymorphism in the promoter region of the tumor necrosis factor alpha (TNF-alpha) gene has been reported to be associated with insulin resistance and obesity, both of which may increase the risk of diabetic nephropathy. We hypothesized that this polymorphism might interact with obesity to affect development of diabetic nephropathy. METHODS A consecutive cohort of 1281 Chinese type 2 diabetic patients was enrolled for analysis. Genotyping of TNF-alpha G-308A polymorphism was performed using a PCR-based RFLP method with NcoI digestion. The mean value of the albumin creatinine ratio (ACR) of a random spot urine sample and a timed urinary collection was used to determine albuminuric status. Diabetic nephropathy was defined as serum creatinine > or =150 micromol/L and/or mean ACR > or =25 mg/mmol. Obesity was defined as body mass index > or =25 kg/m2 using Asian criteria. RESULTS The G-308A polymorphism was not associated with either obesity or nephropathy. Clinical characteristics were similar between GG and GA/AA genotype carriers. Amongst the obese patients, GG genotype carriers had a higher median (interquartile range) urinary ACR [3.16 (0.70, 59.10) vs 1.28 (0.48, 12.28) mg/mmol; p = 0.01] and albumin excretion rate [38.7 (12.1, 620.3) vs 21.4 (8.9, 224.0) microg/min, p = 0.03] than GA/AA carriers. On multiple logistic regression analysis, compared with non-obese GA/AA carriers, obese subjects with the GG genotype had a 2.5-fold increased risk (95% CI: 1.04-6.03; P = 0.04) of nephropathy after adjustment for confounding factors. Other independent factors for diabetic nephropathy included male sex, systolic blood pressure, triglycerides (logarithmically transformed value), and the presence of cardiovascular and microvascular complications. CONCLUSION Our findings suggest that the GG genotype of TNF-alpha G-308A polymorphism or a genetic variant in close linkage disequilibrium may interact with obesity to increase the risk of nephropathy in Chinese Type 2 diabetic patients. Apart from the need for replication of these results, functional studies are required to clarify its significance.
Prognostic impact of highly active antiretroviral therapy in HIV-related Hodgkin's disease.

To evaluate the influence of highly active antiretroviral therapy (HAART) on the outcome of HIV-related Hodgkin's disease (HD), two groups were studied: patients without previous HAART, and patients treated with HAART previously or concomitantly with HD therapy. In the second group, the complete response was higher and the disease-free survival and overall survival probabilities were significantly longer. HAART is thus associated with an improvement in response to therapy and survival in patients with HIV-related HD.
Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan

Although some studies have indicated that endometriosis may increase the risk of developing ovarian cancer, there are no data from epidemiologic studies in Japan. We prospectively analyzed all cases of ovarian endometrioma enrolled in the prefecture-wide Shizuoka Cohort Study on Endometriosis and Ovarian Cancer Programme, which was initiated in 1985. To evaluate the risk of ovarian cancer by time periods subsequent to ovarian endometrioma diagnosis, a cohort of 6,398 women with a clinically documented ovarian endometrioma in Shizuoka between 1985 and 1995 was identified from the Shizuoka Cancer Registry (SCR), with follow-up through 2002. Ovarian cancer incidence among cohort members was ascertained by linkage to the SCR using a unique person-identification number. Standardized incidence ratios (SIR) and their 95% confidence intervals (CI) were computed by a use of prefecture-wide rates of ovarian cancer, adjusted for age and calendar year. During follow-up of up to 17 years of the ovarian endometrioma cohort, 46 incident ovarian cancers were identified, yielding that the ovarian cancer risk was elevated significantly among patients with ovarian endometrioma (SIR = 8.95, 95% CI = 4.12–15.3). The SIR did not increase with increasing follow-up duration. The risk increased with increasing age at ovarian endometrioma diagnosis, with a SIR equal to 13.2 (95% CI = 6.90–20.9) in women above 50 years of age. Our findings for the first time support the hypothesis that ovarian endometrioma increases the subsequent risk of developing ovarian cancer in Shizuoka, Japan
Trail-Using Ant Behavior Based Energy-Efficient Routing Protocol in Wireless Sensor Networks

Swarm Intelligence (SI) observes the collective behavior of social insects and other animal societies. Ant Colony Optimization (ACO) algorithm is one of the popular algorithms in SI. In the last decade, several routing protocols based on ACO algorithm have been developed for Wireless Sensor Networks (WSNs). Such routing protocols are very flexible in distributed system but generate a lot of additional traffic and thus increase communication overhead. This paper proposes a new routing protocol reducing the overhead to provide energy efficiency. The proposed protocol adopts not only the foraging behavior of ant colony but also the trail-using behavior which has never been adopted in routing. By employing the behaviors, the protocol establishes and manages the routing trails energy efficiently in the whole network. Simulation results show that the proposed protocol has low communication overhead and reduces up to 55% energy consumption compared to the existing ACO algorithm.
"Activated"-RecA protein affinity chromatography of LexA repressor and other SOS-regulated proteins.

We have developed an affinity column to study the interaction of LexA repressor and other substrates with the activated form of RecA protein. Nucleoprotein complexes of RecA protein, (dT)25-30, and adenosine 5'-[gamma-S]thio-triphosphate were formed in solution and bound to RecA protein-agarose columns. These "activated"-RecA nucleoprotein complexes were retained by strong hydrophobic interactions. Purified LexA protein bound tightly to these activated RecA columns, whereas the LexA protein bound poorly to RecA-agarose alone. Once bound, LexA protein underwent specific proteolysis, and the fragments were released from the complex. The mutant LexA protein, LexA-SA119, which cannot carry out self-cleavage or RecA-mediated cleavage in solution, bound efficiently to the activated RecA column but was not cleaved, indicating that these columns can be used to identify residues involved in RecA-LexA binding. As an example of this use, nucleoprotein complexes were prepared using the RecA430 protein. In vivo the recA430 mutation blocks induction of the SOS response. LexA protein was not efficiently retained on the immobilized RecA430 complexes, suggesting that Gly-204 is required for efficient repressor binding. These results show that activated RecA affinity columns can be used to investigate the binding and cleaving properties of mutationally altered RecA and LexA proteins. Additionally, these activated RecA columns have been used to investigate binding interactions of phage lambda repressor, as well as the UmuC protein, which is required for chemical mutagenesis.
Preschoolers doing arithmetic: the concepts are willing but the working memory is weak.

The study of early mathematical development provides important insights into young children's emerging academic competencies and, potentially, a basis for adapting instructional methods. We presented nonverbal forms of two- and three-term arithmetic problems to 4-year-olds to determine (a) the extent to which certain information-processing demands make some problems more difficult than others and (b) whether preschoolers use arithmetic concepts spontaneously when solving novel problems. Children's accuracy on simple arithmetic problems (a + b and a - b) was strongly related (r2 = .88) to representational set size, the maximum number of units that need to be held in working memory to solve a given problem. Some children also showed spontaneous use of procedures based on the arithmetic principle of inversion when solving problems of the form a + b - b. These results highlight the importance of identifying information-processing and conceptual characteristics in the early development of mathematical cognition.
Comparison of Transarterial Liver-Directed Therapies for Low-Grade Metastatic Neuroendocrine Tumors in a Single Institution

Objective We compared the clinical outcomes of patients with metastatic neuroendocrine tumors treated with hepatic artery embolization (HAE), chemoembolization (HACE), and selective internal radiation therapy (SIRT) at our institution over the last 10 years. Methods The medical records of 42 patients with metastatic neuroendocrine tumors with hepatic metastases treated with HAE, HACE, or SIRT at the University of Iowa from 2001 to 2011 were analyzed. Results A total of 13 patients had HAE, 17 patients had HACE, and 12 patients had SIRT as their initial procedure. Time to progression (TTP) was similar between SIRT (15.1 months) and HACE/HAE groups (19.6 months; P = 0.968). There was a trend toward increased TTP in patients receiving HACE (33.4 months) compared with HAE (12.1 months) or SIRT (15.1 months), although not statistically significant (P = 0.512). The overall survival for all patients from the first intervention was 41.9 months. There was no difference between HACE/HAE and SIRT in posttherapy change of chromogranin A (P = 0.233) and pancreastatin (P = 0.158) levels. Time to progression did not correlate with the change in the posttherapy chromogranin A (P = 0.299) or pancreastatin (P = 0.208) levels. Conclusions There was no significant difference in TTP in patients treated with SIRT compared with patients treated with HAE or HACE. Baseline and posttherapy marker changes were not predictive of TTP.