Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1β induced inflammation in synoviocytes in vitro.

Osteoarthritis (OA) is a common degenerative joint disease characterized by inflammation of synoviocytes and degradation of cartilage. In the present study, hyaluronic acid/chitosan (HA/CS) nanoparticles were used as a vehicle for gene therapy of OA, and the cytokine response modifier A (CrmA) pDNA was proposed as the target gene. The HA/CS/pCrmA nanoparticles were prepared and the characteristics of the nanoparticles were examined. The nanoparticles were spherical, and the smallest size was obtained with the HA:CS weight ratio of 1:4. The release analysis exhibited a constant release over 29 days. The pDNA was completely combined with HA/CS nanoparticles and the HA/CS nanoparticles protected pDNA from degradation. Subsequently, rat synoviocytes were transfected with HA/CS/pDNA nanoparticles, and the results demonstrated that the HA/CS nanoparticles were able to improve the transfection capacity of pDNA. The cytotoxicity of the HA/CS/pDNA nanoparticles was additionally detected using a MTS assay to ensure that the HA/CS nanoparticle was a safe carrier. To additionally investigate the effects of HA/CS/pCrmA nanoparticles on synoviocytes in OA, the MMP‑3 and MMP‑13 gene expression levels were detected at the gene and protein expression levels. These results indicated that the HA/CS/pCrmA nanoparticles attenuated interleukin‑1β‑mediated inflammation in synoviocytes. It was concluded that the HA/CS/pCrmA nanoparticles may provide a novel approach to the treatment of OA.
Recurrently Controlled Recurrent Networks

Recurrent neural networks (RNNs) such as long short-term memory and gated recurrent units are pivotal building blocks across a broad spectrum of sequence modeling problems. This paper proposes a recurrently controlled recurrent network (RCRN) for expressive and powerful sequence encoding. More concretely, the key idea behind our approach is to learn the recurrent gating functions using recurrent networks. Our architecture is split into two components - a controller cell and a listener cell whereby the recurrent controller actively influences the compositionality of the listener cell. We conduct extensive experiments on a myriad of tasks in the NLP domain such as sentiment analysis (SST, IMDb, Amazon reviews, etc.), question classification (TREC), entailment classification (SNLI, SciTail), answer selection (WikiQA, TrecQA) and reading comprehension (NarrativeQA). Across all 26 datasets, our results demonstrate that RCRN not only consistently outperforms BiLSTMs but also stacked BiLSTMs, suggesting that our controller architecture might be a suitable replacement for the widely adopted stacked architecture. Additionally, RCRN achieves state-of-the-art results on several well-established datasets.
Higher risk of hospitalized infection, cardiovascular disease, and fracture in patients with rheumatoid arthritis determined using the Japanese health insurance database

Abstract Objective: To evaluate the risk of hospitalized infection (HI), cardiovascular disease (CVD), stroke, and fracture in rheumatoid arthritis (RA) patients compared with non-RA patients using the Japanese health insurance database. Method: Among individuals aged ≥18 years, RA cases were defined to have one RA diagnostic code and receiving ≥1 disease-modifying antirheumatic drug between 2005 and 2013 (n = 6,712). Age-, sex-, calendar year of the observation start-, and observation length-matched non-RA cases were selected at 1:5 (n = 33,560). Hazard ratios (HRs) were calculated using the time-dependent Cox regression analysis. Results: Median age of the patients was 52.0 years. The incidence rates of HI, CVD, and fracture in the RA group were 2.42/100 person-years (PY), 4.94/1,000 PY, and 10.59/1,000 PY. The crude incidence rate ratios (95% CI) (RA vs. non-RA) for HI, CVD, and fracture were 2.47 (2.20–2.77), 1.89 (1.49–2.41), and 3.35 (2.80–4.02). The adjusted HR (95% CI) (RA vs. non-RA) was significantly elevated (HI, 1.74 [1.52–1.99], CVD, 1.38 [1.04–1.85], and fracture, 1.88 (1.54–2.31)]. Conclusion: The relatively young RA population had significantly higher risks of these complications than the non-RA, indicating importance of prevention of them even at young ages in clinical settings.
A New Pellistor-Like Gas Sensor Based on Micromachined CMOS Transistor

A new generation of thermal sensors based on a suspended thermal transistor MOS (TMOS), fabricated in the standard CMOS-SOI process, released by postetching, has been recently developed. One of the important features of TMOS is its high responsivity due to the transistor built-in amplification and subthreshold operation enabling a wide range of battery applications. This paper focuses on a new gas sensor, dubbed GMOS, based on the TMOS. The GMOS is a catalytic gas sensor (pellistor-like), and as such detects combustible gases in air. The CMOS-SOI technology combined with tungsten metallization enables operation at very high temperatures (450 °C was tested). The sensors and readout are processed with the same CMOS-SOI technology. Accordingly, the GMOS sensor, processed in low-cost CMOS-SOI technology, promises to become the widely accepted gas sensing approach for mobile applications, including wearables, smart homes, as well as smartphones.
Patterns of Recurrence after Resection for Pancreatic Neuroendocrine Tumors: Who, When, and Where?

Background/Aims: Pancreatic neuroendocrine tumors (pan-NENs) represent an increasingly common indication for pancreatic resection, but there are few data regarding possible recurrence after surgery. The aim of the study was to describe the frequency, timing, and patterns of recurrence after resection for pan-NENs with consequent implications for postoperative follow-up. Methods: We performed a retrospective analysis of pan-NENs resected between 1990 and 2015 at The Pancreas Institute, University of Verona Hospital Trust. Predictors of recurrence were assessed. Survival analysis was conducted using the Kaplan-Meier and conditional survival (CS) methods. Results: The cohort consisted of 487 patients with a median follow-up of 71 months. Recurrence developed in 12.3%: 54 (11.1%) liver metastases, 11 (2.3%) local recurrence, 10 (2.1%) nodal recurrence, and 8 (1.6%) metastases in other organs. Thirty-one (6.4%) died due to disease recurrence. Size > 21 mm, G3 grade, nodal metastasis, and vascular infiltration were independent predictors of overall recurrence. Recurrence occurred either during the first year of follow-up (n = 9), or after 10 years (n = 4). CS analysis revealed that nonfunctioning G1 pan-NEN ≤20 mm without nodal metastasis or vascular invasion had a negligible risk of developing recurrence. In the present series, after 5 years of follow-up without developing recurrence, tumor recurrence occurred only in the form of liver metastases. Conclusions: Recurrence of pan-NENs is rare and is predicted by tumor size, nodal metastasis, grading, and vascular invasion. Patients with G1 pan-NEN without nodal metastasis and vascular invasion may be considered cured by surgery. After 5 years without recurrence, follow-up should focus on excluding the development of liver metastases.
Dolphin echolocation behaviour during active long-range target approaches

ABSTRACT Echolocating toothed whales generally adjust click intensity and rate according to target range to ensure that echoes from targets of interest arrive before a subsequent click is produced, presumably facilitating range estimation from the delay between clicks and returning echoes. However, this click–echo–click paradigm for the dolphin biosonar is mostly based on experiments with stationary animals echolocating fixed targets at ranges below ∼120 m. Therefore, we trained two bottlenose dolphins instrumented with a sound recording tag to approach a target from ranges up to 400 m and either touch the target (subject TRO) or detect a target orientation change (subject SAY). We show that free-swimming dolphins dynamically increase interclick interval (ICI) out to target ranges of ∼100 m. TRO consistently kept ICIs above the two-way travel time (TWTT) for target ranges shorter than ∼100 m, whereas SAY switched between clicking at ICIs above and below the TWTT for target ranges down to ∼25 m. Source levels changed on average by 17log10(target range), but with considerable variation for individual slopes (4.1 standard deviations for by-trial random effects), demonstrating that dolphins do not adopt a fixed automatic gain control matched to target range. At target ranges exceeding ∼100 m, both dolphins frequently switched to click packet production in which interpacket intervals exceeded the TWTT, but ICIs were shorter than the TWTT. We conclude that the click–echo–click paradigm is not a fixed echolocation strategy in dolphins, and we demonstrate the first use of click packets for free-swimming dolphins when solving an echolocation task. Summary: Echolocating dolphins can use three modes of range-dependent click rate adjustment during long-range target approaches, and adjust click intensity with range, but not to perceive constant echo levels.
Characteristics of the complete mitochondrial genome of Suhpalacsa longialata (Neuroptera, Ascalaphidae) and its phylogenetic implications

The owlflies (Family Ascalaphidae) belong to the Neuroptera but are often mistaken as dragonflies because of morphological characters. To date, only three mitochondrial genomes of Ascalaphidae, namely Libelloides macaronius; Ascaloptynx appendiculatus; Ascalohybris subjacens, are published in GenBank, meaning that they are greatly under-represented in comparison with the 430 described species reported in this family. In this study, we sequenced and described the complete mitochondrial genome of Suhpalacsa longialata (Neuroptera, Ascalaphidae). The total length of the S. longialata mitogenome was 15,911 bp, which is the longest known to date among the available family members of Ascalaphidae. However, the size of each gene was similar to the other three Ascalaphidae species. The S. longialata mitogenome included a transposition of tRNACys and tRNATrp genes and formed an unusual gene arrangement tRNACys-tRNATrp-tRNATyr (CWY). It is likely that the transposition occurred by a duplication of both genes followed by random loss of partial duplicated genes. The nucleotide composition of the S. longialata mitogenome was as follows: A = 41.0%, T = 33.8%, C = 15.5%, G = 9.7%. Both Bayesian inference and ML analyses strongly supported S. longialata as a sister clade to (Ascalohybris subjacens + L. macaronius), and indicated that Ascalaphidae is not monophyletic.
Signature-Based Nonorthogonal Massive Multiple Access for Future Wireless Networks: Uplink Massive Connectivity for Machine-Type Communications

The problem of providing massive connectivity in the Internet of Things (IoT) with a limited number of available resources motivates nonorthogonal multiple access (NOMA) solutions. In this article, we provide a comprehensive review of the signature-based NOMA (S-NOMA) schemes as potential candidates for IoT. The signature in S-NOMA represents the way the data stream of an active device is spread over available resources in a nonorthogonal manner. It can be designed based on device-specific codebook structures, delay patterns, spreading sequences, interleaving patterns, and scrambling sequences. Additionally, we present the detection algorithms employed to decode each device's data from nonorthogonally superimposed signals at the receiver. The bit error rate (BER) of different S-NOMA schemes is simulated in impulsive noise environments, which can be important in machine-type communications (MTCs). Simulation results show that the performance of the S-NOMA schemes degrades under such conditions. Finally, research challenges in S-NOMA-oriented IoT are presented.
Aberrant functional connectivity of neural circuits associated with social and sensorimotor deficits in young children with autism spectrum disorder

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by atypical functional integration of brain regions. The vast majority of neuroimaging studies of ASD have focused on older children, adolescents, and adults with the disorder. Very little work has explored whole‐brain functional connectivity of young children with ASD. Here, we collected resting‐state functional magnetic resonance imaging data from 58 young children (mean age 4.98 years; 29 with ASD; 29 matched healthy controls [HC]). All children were under sedation during scanning. A functional “connectedness” method was first used to seek for brain regions showing atypical functional connectivity (FC) in children with ASD. Then, a recurrent‐seek strategy was applied to reveal atypical FC circuits in ASD children. FC matrices between regions‐of‐interest (ROIs) were compared between ASD and HC. Finally, a support vector regression (SVR) method was used to assess the relationship between the FC circuits and ASD symptom severity. Two atypical FC circuits comprising 23 ROIs in ASD were revealed: one predominantly comprised brain regions involved with social cognition showing under‐connectivity in ASD; the other predominantly comprised sensory‐motor and visual brain regions showing over‐connectivity in ASD. The SVR analysis showed that the two FC circuits were separately related to social deficits and restricted behavior scores. These findings indicate disrupted FC of neural circuits involved in the social and sensorimotor processes in young children with ASD. The finding of the atypical FC patterns in young children with ASD underscores the utility of studying younger children with the disorder, and highlights nuanced patterns of brain connectivity underlying behavior closer to disorder onset. Autism Research 2018, 11: 1643–1652. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.
Effect of Dexamethasone in the Development of O1 or O4 Immunoreactive Oligodendrocyte of the Neonatal Rat

White matter disease (WMD) study, which underlies the subsequent progress of cerebral palsy as well as cognitive impairment of premature and/or low birth weight infants, has been focused either on the hypoxia-ischemia damage or cytokine-induced brain damage related with maternal or fetal inflammation. Also, dexamethasone (DEXA) may increase the risk of neuropsychological problem including adverse cognitive and behavioral outcome in preterm infants. Thus, we hypothesized that perinatal DEXA would damage and trigger the death of developing oligodendrocytes (OL) progenitors, and subsequently disturb myelination. In this study, DEXA was administered to neonatal rats for 3 consecutive days subcutaneously between postnatal day 1 (P1) and P3. By using immunofluorescent staining of stage specific OL progenitor markers such as O4 and O1, the morphological changes of OL progenitors were examined and the apoptosis of OL progenitors were visualized by TUNEL staining. Results depicted that relative number of O1 immunoreactive (IR) cells were less to that of O4 IR cells. Multipolar O1 IR cells with short dendritic processes were observed in both control and DEXA group at P3. In the total O1 immunoreactive cells, the relative percentages of apoptosis cells were calculated at P3 as 8.7% in control, 23.0% in DEXA group. The relative percentages of apoptosis in the total O4 immunoreactive cells were measured at P3 as 3.0% in control and 13.5% in DEXA group. OL progenitors' apoptosis may contribute to the overall reduction of immature OLs in cerebral white matter. Therefore, specific stages of OL maturation could clinically be an important factor in determining the susceptibility to DEXA. To elucidate the disease mechanism of the white matter disease, further investigation may be needed whether OL progenitors' decrease by the DEXA administration affects to the myelin formation as developmental stages.
Sports Heroes and Mass Sports Participation – the (Double) Paradox of the 'German Tennis Boom'

The major sporting success of one’s countrymen and women is often supposed to promote the growth of general participation in that sport. This study is the first to analyse the impact of sports heroes on the membership figures of the corresponding sports association by means of an econometric analysis. We do so by evaluating the so-called "Boris Becker effect" by simultaneously testing for the effects of the rise and retirement of the three stars Boris Becker, Stefanie Graf, and Michael Stich. As a first paradox, our results indicate a negative tennis growth effect associated with the time period of the ascendency of the sport stars. With the first paradox, their retirement should then have a positive effect. In this sense, our second result of a statistically negative tennis growth since the declining success of the German tennis stars must be regarded as a second paradox.
A new microvertebrate assemblage from the Mussentuchit Member, Cedar Mountain Formation: insights into the paleobiodiversity and paleobiogeography of early Late Cretaceous ecosystems in western North America

The vertebrate fauna of the Late Cretaceous Mussentuchit Member of the Cedar Mountain Formation has been studied for nearly three decades, yet the fossil-rich unit continues to produce new information about life in western North America approximately 97 million years ago. Here we report on the composition of the Cliffs of Insanity (COI) microvertebrate locality, a newly sampled site containing perhaps one of the densest concentrations of microvertebrate fossils yet discovered in the Mussentuchit Member. The COI locality preserves osteichthyan, lissamphibian, testudinatan, mesoeucrocodylian, dinosaurian, metatherian, and trace fossil remains and is among the most taxonomically rich microvertebrate localities in the Mussentuchit Member. To better refine taxonomic identifications of isolated theropod dinosaur teeth, we used quantitative analyses of taxonomically comprehensive databases of theropod tooth measurements, adding new data on theropod tooth morphodiversity in this poorly understood interval. We further provide the first descriptions of tyrannosauroid premaxillary teeth and document the earliest North American record of adocid remains, extending the appearance of this ancestrally Asian clade by 5 million years in western North America and supporting studies of pre-Cenomaninan Laurasian faunal exchange across Beringia. The overabundance of mesoeucrocodylian remains at the COI locality produces a comparatively low measure of relative biodiversity when compared to other microvertebrate sites in the Mussentuchit Member using both raw and subsampling methods. Much more microvertebrate research is necessary to understand the roles of changing ecology and taphonomy that may be linked to transgression of the Western Interior Seaway or microhabitat variation.
What Do You Believe In? French Translation of the FAD-Plus to Assess Beliefs in Free Will and Determinism and Their Relationship with Religious Practices and Personality Traits

The influence of (dis)belief in free will on prosocial behaviors and sense of control has attracted considerable interest over the last few years. The provision of relevant research tools to assess beliefs in free will and determinism for the community thus becomes a central endeavour. However, no relevant validated questionnaires are currently available to the French language community. Therefore, the present study was aimed at providing a valid French translation of the FAD-plus (Paulhus & Carey, 2011), a questionnaire built to assess people’s beliefs in Free will and Determinism. Exploratory factor analysis of the data obtained in Sample 1 revealed a four factor model. Confirmatory factor analyses on the basis of Sample 2 data were conducted to compare the theoretical model advanced by Paulhus and Carey’s versus the model obtained in Sample 1. With only but a few modifications as compared to the original questionnaire, the questionnaire that we here propose appears to constitute a reliable tool for the French language community. We also examined the relationship between beliefs in free will, determinism and religious practices. We found that the more people are engaged in religious practices, the more they believe in determinism and in the inevitability of their future.
Context-Dependence and Context-Invariance in the Neural Coding of Intentional Action

Maintaining intentions over time is fundamental to goal-directed action, and previous research demonstrated that intentions are encoded and maintained in a fronto-parietal network including e.g., the dlPFC and IPS. Yet, intention maintenance is highly challenging in the constantly changing environments we experience every day. While we might have formed an intention under specific conditions, this context can change rapidly and unexpectedly. Some suggested that intentions representations in the fronto-parietal cortex change flexibly when external demands change (context-dependent coding). Others suggested that these representations are encoded in an abstract format that is not affected by changes in external demands (context-invariant coding). Here, I will first outline an analysis approach using multivariate pattern analysis of fMRI data to comprehensively assess the context-dependence / invariance of intention representations in the fronto-parietal cortex. I will then highlight some research following the proposed analysis strategy. Results to date are mixed, showing context-dependence in some, but context-invariance in other cases. In an attempt to synthesize these somewhat divergent results, I will argue that depending on characteristics of the intentions as well as the environment, intentions can either be encoded in a context-dependent or a context-invariant format. This enables us to achieve both stability and flexibility of behavior under constantly changing external demands.
Axillary Surgery in Breast Cancer Patients Treated with Breast-Conserving Surgery at German Breast Cancer Centers Within the Last 14 Years – Comparison of a University Center and a Community Hospital

Abstract Background Guideline recommendations for axillary surgical approach in breast cancer (BC) treatment changed over the last decade. Methods Data from all invasive BC patients (n = 5344) treated with breast conserving surgery (BCS) at the breast cancer centers of the University Hospital Ulm (U‑BCC) and the community hospital Dachau (D‑BCC) were included into a retrospective analysis for assessing information on axillary surgery between 2003 and 2016 based on the documented cancer registry data. Results The average annual rate of sentinel node biopsy (SNB) was 85.5 % and 87.2 % in Ulm and Dachau, respectively. SNB was performed more precisely at the U‑BCC with a median of 2.4 resected lymph nodes (LN) compared to a median of 3.2 resected LN in Dachau. Median number of resected LN for axillary lymph node dissection (ALNE) showed a statistically significant reduction over time in Ulm (rs = − 0.82; p < 0.001) and Dachau (rs = − 0.76; p = 0.002). The rate of secondary ALNE (after SNB; 2° ALNE) decreased significantly in U‑BCC (rs = − 0.76; p = 0.002) while it remained stable in D‑BCC. The influential publication of the Z0011 study in 2010 resulted in a significant reduction of secondary ALNE (24.1 % pre Z0011 and 14.4 % postZ0011; p < 0.001) in Ulm. Conclusion Changes in axillary surgery over time can be seen in the annual statistics of the reviewed BCCs. With BCS, mostly SNB was performed and numbers of removed LN in ALNE have decreased. In the U‑BCC, the rate of 2° ALNE dropped after the publication of the Z0011 data. The fact that no such decrease for 2° ALNE was found in D‑BCC suggests that university hospitals implement new data and research results into clinical routine earlier than peripheral community hospitals.