Miracle-dz/UniFAR-FTUs huggingface dataset:
Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.

CONTEXT Insulinomas represent pancreatic neuroendocrine neoplasms that cause severe morbidity attributed to their often pronounced endocrine activity. Apart from hereditary forms such as multiple endocrine neoplasia type 1 (MEN-1), genetic causes for sporadic insulinoma development had remained obscure until recently. Applying next-generation sequencing methods, disease-causing genetic alterations have been identified in various endocrine tumors. OBJECTIVE AND DESIGN Paired tumor and blood DNA from eight patients with sporadic insulinomas (five females and two malignant tumors) were analyzed by whole-exome sequencing. After this initial analysis, Ying Yang 1 (YY1) mutation status was assessed in a larger cohort of 39 additional insulinomas (including eight malignant and one liver metastasis) from three German hospitals by targeted sequencing. The mutation status was correlated with various clinical parameters. RESULTS A range of one to 12 somatic genetic variants were identified by exome sequencing. A recurrent somatic Thr372Arg YY1 point mutation was detected in two patients of the initial cohort and four patients of the second cohort (total, six of 47; 13%). The presence of the mutation was associated with a trend toward higher age (63.5 y; IQR, 48.0-74.0 vs 45.0 y; IQR, 33.0-63.0; P = .05), and all affected patients were females (six of six; P = .04). All other clinical parameters, including the presence of malignancy and metastatic spread, tumor localization, and hypoglycemic episodes were not different between YY1-mutated and nonmutated tumor carriers. CONCLUSIONS The somatic Thr372Arg YY1 mutation is a relevant finding in female patients with sporadic insulinomas. The prevalence of this mutation in this Caucasian population is considerably lower compared to that of a recently described Asian cohort.
A prospective, international phase 2 study of bortezomib retreatment in patients with relapsed multiple myeloma

Multiple myeloma (MM) typically follows a relapsing course with many patients requiring multiple therapies. This single‐arm phase 2 study prospectively evaluated the efficacy and safety of bortezomib retreatment in MM patients who had relapsed after achieving at least a partial response (≥PR) to prior bortezomib‐based therapy.
Phenomenology of dark energy: general features of large-scale perturbations

We present a systematic exploration of dark energy and modified gravity models containing a single scalar field non-minimally coupled to the metric. Even though the parameter space is large, by exploiting an effective field theory (EFT) formulation and by imposing simple physical constraints such as stability conditions and (sub-)luminal propagation of perturbations, we arrive at a number of generic predictions. (1) The linear growth rate of matter density fluctuations is generally suppressed compared to ΛCDM at intermediate redshifts (0.5 ≲ z ≲ 1), despite the introduction of an attractive long-range scalar force. This is due to the fact that, in self-accelerating models, the background gravitational coupling weakens at intermediate redshifts, over-compensating the effect of the attractive scalar force. (2) At higher redshifts, the opposite happens; we identify a period of super-growth when the linear growth rate is larger than that predicted by ΛCDM. (3) The gravitational slip parameter η—the ratio of the space part of the metric perturbation to the time part—is bounded from above. For Brans-Dicke-type theories η is at most unity. For more general theories, η can exceed unity at intermediate redshifts, but not more than about 1.5 if, at the same time, the linear growth rate is to be compatible with current observational constraints. We caution against phenomenological parametrization of data that do not correspond to predictions from viable physical theories. We advocate the EFT approach as a way to constrain new physics from future large-scale-structure data.
Understanding Distress in Posttreatment Adult Leukemia and Lymphoma Survivors: A Lifespan Perspective

Using in-depth interviews, this paper explores the nature and sources of cancer-specific distress among 51 posttreatment adult leukemia and lymphoma survivors (LLS), focusing on the role of lifespan stage in shaping reported stressors. LLS (all ages) reported physical aftereffects of cancer treatment, with reported sources of emotional and financial distress varying by lifespan stage. Young adult survivors (18–39) reported a greater number of distress sources. Distress may persist up to 4 years posttreatment, particularly among younger LLS, who appear to be at greater risk of distress in multiple domains.
Pengaruh Peran Audit Internal Dan Penerapan Prinsip-Prinsip Good Corporate Governance Terhadap Pencegahan Kecurangan

Abstract. The era of globalization like now rapid economic growth had generated intense competition. Survive in the face of competition and more stringent problems , the management needed help from this check or internal audit internal. The purpose of this research is to find the effect of the role of internal audit and the implementation of principles of good corporate governance to prevention fraud. This research was done in some BUMN Bandung City.This research was using descriptive and quantitative method. The data collection in this research was using questionnaire with auditors internal in some BUMN Bandung City with number of 32 respondents. The data analysis technique that used was double linear regression analysis with the help of data analysis tool SPSS (Statistical Product and Service Solutions). The result of this research show that internal audit and the implementation of principles of good corporate governance have a very good effect in partial or simultancous to prevention fraud. Based upon analysis result, strong connection also shown by 2 free variable for prevention fraud. Abstrak. Era globalisasi seperti sekarang pertumbuhan ekonomi yang pesat telah menimbulkan persaingan ketat. Bertahan dalam menghadapi persaingan yang semakin ketat dan berbagai masalah, manajemen perusahaan membutuhkan bantuan dari fungsi pemeriksaan intern atau audit internal. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh peran audit internal serta penerapan prinsip-prinsip good corporate governance terhadap pencegahan kecurangan. Penelitian ini dilakukan di beberapa BUMN di Kota Bandung. Penelitian ini menggunakan metode penelitian deskriptif kuantitatif. Pengumpulan data pada penelitian ini menggunakan kuesioner dengan sampel auditor internal di beberapa BUMN di Kota Bandung sebanyak 32 responden. Teknik analisis data yang digunakan adalah analisis regresi linier berganda dengan bantuan alat analisis data SPSS ( Statistical Product and service solutions ). Hasil penelitian ini menunjukan bahwa peran audit internal serta penerapan prinsip-prinsip good corporate governance berpengaruh signifikan terhadap pencegahan kecurangan. Berdasarkan hasil analisis, hubungan yang kuat juga ditunjukkan kedua variabel bebas terhadap pencegahan kecurangan.
Contextual factors of performance measurement systemsdesign in Libyan commercial banks

Based on the contingency theory, this study examines the contextual factors that influence the design of performance measurement systems (PMS). Specifically, this study examines the influence of business strategy and organizational structure on the choice of measurements in Libyan commercial banks. Since the early 1980s, contingency-based research has focused on the search for the best design of management control systems. This research renews this idea by including two factors - business strategy and organizational structure. This research is conducted to contribute to the inconclusive and limited evidence concerning the influence of contextual variables in the design of PMS, particularly in the service industry in less developed countries, such as Libya. The data were gathered from Libyan commercial banks using a survey questionnaire mailed to the branch managers. Data analysis was conducted by employing descriptive analysis, factor analysis, reliability analysis, and multiple regression. The findings show that business strategy has a positive and significant relationship with PMS, while organizational structure has an insignificant influence on PMS design. The results of this study imply that managers should consider the contextual factors that may influence the choice of performance measures, so that the design of their PMS will result in better organizational performance.
Voltage controlled ferroelectric lens phased arrays

Phased array antennas can steer transmitted and received signals without mechanically rotating the antenna. Each radiating element of a phased array is normally connected to a phase shifter, which determines the phase of the signal at each element to form a beam at the desired angle. The most commonly used phase shifters are ferrite and diode phase shifters. Phase shifters using ferroelectric materials have been proposed previously. A typical phased array may have several thousand elements and is very expensive. Therefore, reducing the cost and complexity of the phase shifters and the phase shifter controls is an important consideration in the design of phased arrays. The phased array described uniquely incorporates bulk phase shifting, the array does not contain individual phase shifting, using a ferroelectric material along with simpler phase shift control. Bulk phase shifting using diodes has been proposed and developed in the Radant lens. The lens described uses a voltage controlled ferroelectric, which introduces an analog phase shift rather than a digital phase shift as in the Radant lens. The ferroelectric lens has further advantages of smaller lens thickness, higher power handling, simpler beam steering controls, and it uses less power to control the phase shift compared to the Radant lens. Thus, it can potentially lead to low cost phased arrays.
Modification by Phosphate of PTH-Dependent Renal Cyclic AMP Response

The PTH response and the renal cAMP response obtained after oral administration of either tricalcium phosphate or calcium gluconolactate were compared in 12 young adult males. Each subject was studied during a control period of two hours before and during an experimental period of four hours after ingestion of a single oral dose of calcium salt. The respective dosages (1.2 g of calcium plus 0.6 g phosphorus for tricalcium phosphate; 0.5 g of calcium for gluconolactate calcium) were chosen to provide similar significant (p = 0.0001) increases in serum ionized calcium (from 1.23 to 1.29 mmol/l vs from 1.23 to 1.28 mmol/l). After tricalcium phosphate a modest (10%) but significant (p < 0.001) rise in serum phosphate was observed. In both series of experiments similar inhibitory effects on PTH circulating levels were obtained (from 22.6 to 12.4 pg/ml after tricalcium phosphate and from 24.1 to 10.6 pg/ml after calcium gluconolactate). After ingestion of calcium gluconolactate the renal secretion of cAMP fell from 12.68 to 8.64 nmol/l GF (p < 0.001), whereas no significant alterations of the mean values of nephrogenous cAMP were detected after ingestion of tricalcium phosphate. In accordance with the role of cAMP as a second messenger, after calcium gluconolactate we obtained a significant increase in tubular maximal reabsorption of phosphate (p < 0.0001) contrasting with the absence of significant effect after tricalcium phosphate. The present results confirm that suppression of PTH secretion only depends on the rise of serum ionized calcium and suggest that additional phosphate administration could have a decoupling effect between PTH and renal cAMP secretion.
Realization of a compact polarization splitter-rotator on silicon.

A novel compact polarization splitter-rotator (PSR) is proposed and realized with silicon-on-insulator nanowires. The present PSR consists of an adiabatic taper, an asymmetric directional coupler (ADC), and a multimode interference (MMI) mode filter. The adiabatic taper enables an efficient mode conversion from the launched TM0 mode to the TE1 mode in a wide waveguide, which is then coupled to the TE0 mode of a narrow waveguide through the ADC. Meanwhile, the launched TE0 mode does not have mode conversion and outputs from the through port directly. The MMI mode filter is cascaded at the through port to filter out the residual power of the TE1 mode so that the extinction ratio of the PSR is improved greatly. The total length of the PSR is ∼70 μm and the fabricated PSR has an extinction ratio of ∼20 dB over a broadband ranging from 1547 to 1597 nm.
Diabetes-Induced Oxidative Stress Is Mediated by Ca2+-Independent Phospholipase A2 in Neutrophils

Neutrophils from people with poorly controlled diabetes present a primed phenotype and secrete excessive superoxide. Phospholipase A2 (PLA2)-derived arachidonic acid (AA) activates the assembly of NADPH oxidase to generate superoxide anion. There is a gap in the current literature regarding which PLA2 isoform regulates NADPH oxidase activation. The aim of this study was to identify the PLA2 isoform involved in the regulation of superoxide generation in neutrophils and investigate if PLA2 mediates priming in response to pathologic hyperglycemia. Neutrophils were isolated from people with diabetes mellitus and healthy controls, and HL60 neutrophil-like cells were grown in hyperglycemic conditions. Incubating neutrophils with the Ca2+-independent PLA2 (iPLA2) inhibitor bromoenol lactone (BEL) completely suppressed fMLP-induced generation of superoxide. The nonspecific actions of BEL on phosphatidic acid phosphohydrolase-1, p47phox phosphorylation, and apoptosis were ruled out by specific assays. Small interfering RNA knockdown of iPLA2 inhibited superoxide generation by neutrophils. Neutrophils from people with poorly controlled diabetes and in vitro incubation of neutrophils with high glucose and the receptor for advanced glycation end products ligand S100B greatly enhanced superoxide generation compared with controls, and this was significantly inhibited by BEL. A modified iPLA2 assay, Western blotting, and PCR confirmed that there was increased iPLA2 activity and expression in neutrophils from people with diabetes. AA (10 μM) partly rescued the inhibition of superoxide generation mediated by BEL, confirming that NADPH oxidase activity is, in part, regulated by AA. This study provides evidence for the role of iPLA2 in enhanced superoxide generation in neutrophils from people with diabetes mellitus and presents an alternate pathway independent of protein kinase C and phosphatidic acid phosphohydrolase-1 hydrolase signaling.
Lower extremity power during the squat jump with various barbell loads

The purpose of this study was twofold: (1) to determine the barbell load that maximised the system power as well as the ankle, knee, and hip joint powers during the squat jump, and (2) to compare the system powers computed from two different methods: the centre of mass (COM) method and the barbell method. Seven male throwers were recruited in this study. The system power (COM method) and the ankle, knee, and hip joint powers were determined with the load incrementally set at 0%, 10%, 30%, 50%, 70%, and 90% of one repetition maximum. The largest system power was observed at the load of 30% (p < 0.008) while the largest ankle and knee powers were observed at 70% and 0% (p < 0.05). The barbell method overestimated the system power (p < 0.001) when compared to the COM method. It was concluded that the barbell method could influence load optimisation in squat jump. The optimal barbell load which maximised the system power did not maximise the ankle, knee, or hip power simultaneously.
Future provision of orthodontic care for patients with craniofacial anomalies and cleft lip and palate.

OBJECTIVE To determine whether Canadian and United States (US) orthodontic programs provide training in treating patients with cleft lip and palate (CLP) and craniofacial anomalies (CFA) and whether residents will treat these patients in their future practices. METHODS An email with a personalized link to an anonymous, multi-item, online questionnaire was sent to all 54 Canadian and 335 of the approximately 700 US orthodontic residents. The two questions asked were: "Do you plan to include the treatment of CLP and CFA patients in your practice? " and "Does your program contain formal training in treating patients with CLP and CFA? " RESULTS A total of 44 Canadian and 136 US residents responded. In Canada, 30% plan to treat patients with CLP and CFA after graduation, 14% said no, 48% said maybe, and 9% were unsure. In the US, 53% said yes, 7% said no, 36% said maybe, and 4% were unsure. When asked if their program offers formal training in the treatment of these patients, 45% of Canadian residents said yes, 34% said no, and 20% were unsure, whereas 82% of US residents said yes, 12% said no, and 5% were unsure. CONCLUSION Most programs in the US and approximately half in Canada provide training in CLP and CFA, and more than half of US and almost one-third of Canadian residents plan to be involved in the care of patients with CLP and CFA, which is considerably less than those receiving training. Orthodontic programs need to increase the number of postgraduate students who are interested in providing care to CLP and CFA patients after becoming orthodontists.
Estimation of the break-even point for smoking cessation programs in pregnancy.

BACKGROUND Successful programs to help pregnant women quit smoking have been developed and evaluated, but formal smoking cessation programs are not a part of care at most prenatal sites. The cost of such programs may be an issue. Considering the costs of adverse maternal and infant outcomes resulting from smoking, we estimated there would be an amount of money a prenatal program could invest in smoking cessation and still "break even" economically. METHODS A model was developed and published data, along with 1989 hospital charge data, were used to arrive at a break-even point for smoking cessation programs in pregnancy. RESULTS Using overall United States data, we arrived at a break-even cost of $32 per pregnant woman. When these data were varied to fit specific US populations, the break-even costs varied from $10 to $237, with the incidence of preterm low birth weight having the most impact on the cost. CONCLUSIONS It may be advisable to invest greater amounts of money in a prenatal smoking cessation program for some populations. However, for every population there is an amount that can be invested while still breaking even.
Measuring Readiness For Career-Decision Making with the Career Thoughts Inventory in Finland: Adaption or Adoption: Technical Report No. 54

The aim of this study was to examine the adaptation versus adoption of the Career Thoughts Inventory (CTI, Sampson, Peterson, Lenz, Reardon, & Saunders, 1996a) outside the U.S. as a measure readiness for career decision-making. A sample of Finnish polytechnic students (N = 666) completed a Finnish-language version of the CTI. A principle components analysis identified three components: Decision-Making Confusion, Commitment Anxiety, and External Conflict. The results were in accordance with the findings of the U.S. validation studies. The three-factor model explained 36.97% of the total variance. Given the Finnish translation of the CTI, the factor structure and reliability coefficients supported the construct validity of CTI scores and partial structural equivalence was observed. The results demonstrated that it would be appropriate to adapt, not to adopt, the CTI based on CIP theory to the Finnish context. Before implementation of the Finnish CTI in practice, certain modifications in items and scales are warranted.
Multidisciplinary treatment of malignant thymoma

Purpose of review Thymomas are the most common tumors of the anterior mediastinum. Although surgery remains the only curative treatment, the use of multimodality therapy for primary unresectable thymomas has led to change the clinical management of these tumors. Recent findings Nowadays Masaoka stage, WHO, and radical surgical resection are considered by many authors as independent prognostic factors for long-term survival. Radiotherapy may be useful as adjuvant therapy in cases of incomplete surgical resection with microscopic or macroscopic residual disease, or for those patients with locally advanced or metastatic unresectable disease. Chemotherapy is considered a valid option in selected patients with residual disease after local treatments or as a neoadjuvant approach to improve resectability in Masaoka stages III or IV-a thymomas. Currently, no standardized regimen for chemotherapy or agreed timing exists. Summary So far, multimodality treatment has been related to low morbidity and long survival rate, but there are still many concerns regarding a different regimen of therapy and the correct timing.
CLE Peptides Control Medicago truncatula Nodulation Locally and Systemically1[C][W][OA]

The CLAVATA3/embryo-surrounding region (CLE) peptides control the fine balance between proliferation and differentiation in plant development. We studied the role of CLE peptides during indeterminate nodule development and identified 25 MtCLE peptide genes in the Medicago truncatula genome, of which two genes, MtCLE12 and MtCLE13, had nodulation-related expression patterns that were linked to proliferation and differentiation. MtCLE13 expression was up-regulated early in nodule development. A high-to-low expression gradient radiated from the inner toward the outer cortical cell layers in a region defining the incipient nodule. At later stages, MtCLE12 and MtCLE13 were expressed in differentiating nodules and in the apical part of mature, elongated nodules. Functional analysis revealed a putative role for MtCLE12 and MtCLE13 in autoregulation of nodulation, a mechanism that controls the number of nodules and involves systemic signals mediated by a leucine-rich repeat receptor-like kinase, SUNN, which is active in the shoot. When MtCLE12 and MtCLE13 were ectopically expressed in transgenic roots, nodulation was abolished at the level of the nodulation factor signal transduction, and this inhibition involved long-distance signaling. In addition, composite plants with roots ectopically expressing MtCLE12 or MtCLE13 had elongated petioles. This systemic effect was not observed in transgenic roots ectopically expressing MtCLE12 and MtCLE13 in a sunn-1 mutant background, although nodulation was still strongly reduced. These results suggest multiple roles for CLE signaling in nodulation.