Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of effect of <i>Nigella sativa</i> oil in paracetamol induced hepatotoxicity in albino rats

Background: Acetaminophen (paracetamol) toxicity is a common cause of drug‑induced hepatotoxicity in children and adults. Specific treatment of paracetamol induced hepatitis is available in the form of N‑acetylcysteine only. Nigella sativa (NS) is used for the treatment of various ailments. Many studies have shown that NS plant has hepatoprotective potential. Hence, this study study was carried out to explore the prophylactic and therapeutic effect of NSoil against hepatotoxicity induced by paracetamol. Methods: Hepatotoxicity was induced in rats by paracetamol and it was assessed using biochemical parameters such as serum (Sr.) alanine aminotransferase (ALT), Sr. aspartate aminotransferase (AST), Sr. bilurubin, Sr. alkaline phosphatase, and Sr. total protein. In addition, histopathological score was also assessed. The therapeutic and prophylactic effect of NSoil administration on paracetamol induced hepatotoxicity was investigated by using above mentioned biochemical and histopathological parameters. Results: Paracetamol administration leads to rise in serum liver enzymes ad fall in Sr. total protein levels. NS oil has heptoprotective effect. NS oil significantly reversed changes in serum levels of AST, ALT, alkaline phophatase, bilurubin, and total protein produced by paracetamol. Furthermore, histopathological changes produced by paracetamol were reversed. Conclusion: This study demonstrated that NS oil has hepatoprotective effect.NS oiladministration can prevent or reverse the hepatotoxicity induced by paracetamol.
Early development of pleuroperitoneal fold of the diaphragm in the rat fetus

The embryonic diaphragm comprises four major structural components derived from the transverse septum, the dorsal foregut mesentery, the pleuroperitoneal folds (PPFs), and the body wall. In this study, the appearance of PPFs and related factors were investigated using light microscopy of horizontal sections of rat fetuses from embryonic day 12 to 13. In rat fetuses, the sign of PPF projection was noted in the sidewall of the pericardioperitoneal canal at embryonic day 12, and was confirmed as folds at embryonic day 12.25. Expressions of GATA4, COUP-TF2, and FOG2 were detected in PPF at the early stage of formation. Localizations of these factors suggested that COUP-TF2 and FOG2 are the main factors in PPF appearance and that GATA4 is unlikely to be a main factor, although it is necessary for PPF formation.
A Review of the Genus Neoechinorhynchus (Acanthocephala: Neoechinorhynchidae) from Australia with the Description of Two New Species

Abstract Eight species of Neoechinorhynchus were reported from Australian waters. Neoechinorhynchus vittiformis n. sp. is described from Eleutheronema tetradactylum (Shaw). It can be distinguished from all its congeners by the following combination of characters: long cylindrical trunk without cuticular plaques, globular proboscis, proboscis armature with the anterior circle of hooks larger with simple roots and the middle and posterior hooks the same size and smaller, short neck, lemnisci nearly equal, almost reaching the anterior testis which is more than half the length of the posterior testis. Neoechinorhynchus (Neoechinorhynchus) bryanti n. sp. , described from Liza subviridis (Valenciennes), also with an elongated trunk, can be distinguished from its congeners by the combination of a wider anterior trunk without cuticular plaques, a relatively long conical neck, a subglobular proboscis having anterior hooks with manubria, the hooks becoming gradually smaller posteriorly, the lemnisci not reaching level of testes and the anterior testis being longer than posterior testis. Neoechinorhynchus sp. resembled Neoechinorhynchus aldrichettae Edmonds, 1971 but had a rectangular-shaped proboscis with larger anterior hooks. New host and locality records were presented for N. aldrichettae, Neoechinorhynchus (Hebesoma) agilis (Rudolphi) and Neoechinorhynchus tylosuri Yamaguti, 1939. No additional specimens of either Neoechinorhynchus ningalooensis Pichelin and Cribb, 2001 or the species inquirenda, Neoechinorhynchus magnus Southwell and Macfie, 1925, were available for study. Of the 8 putative species listed here, 5 (N. [N.] bryanti, N. magnus, N. ningalooensis, N. vittiformis, and Neoechinorhynchus sp.) are endemic to Australian waters. By comparison with the North American fauna the Australian fauna was considered impoverished. The morphological and zoogeographical similarities within the group of 8 long, slender neoechinorhynchid species found in the African, Indo Malayan, and Western Pacific Regions, including the 3 found in Australia, may reflect a degree of evolutionary affinity.
TrillionG: A Trillion-scale Synthetic Graph Generator using a Recursive Vector Model

As many applications encounter exponential growth in graph sizes, a fast and scalable graph generator has become more important than ever before due to lack of large-scale realistic graphs for evaluating the performance of graph processing methods. Although there have been proposed a number of methods to generate synthetic graphs, they are not very efficient in terms of space and time complexities, and so, cannot generate even trillion-scale graphs using a moderate size cluster of commodity machines. Here, we propose an efficient and scalable disk-based graph generator, TrillionG that can generate massive graphs in a short time only using a small amount of memory. It can generate a graph of a trillion edges following the RMAT or Kronecker models within two hours only using 10 PCs. We first generalize existing graph generation models to the scope-based generation model, where RMAT and Kronecker correspond to two extremes. Then, we propose a new graph generation model called the recursive vector model, which compromises two extremes, and so, solves the space and time complexity problems existing in RMAT and Kronecker. We also extend the recursive vector model so as to generate a semantically richer graph database. Through extensive experiments, we have demonstrated that TrillionG outperforms the state-of-the-art graph generators by up to orders of magnitude.
OctopusFS: A Distributed File System with Tiered Storage Management

The ever-growing data storage and I/O demands of modern large-scale data analytics are challenging the current distributed storage systems. A promising trend is to exploit the recent improvements in memory, storage media, and networks for sustaining high performance and low cost. While past work explores using memory or SSDs as local storage or combine local with network-attached storage in cluster computing, this work focuses on managing multiple storage tiers in a distributed setting. We present OctopusFS, a novel distributed file system that is aware of heterogeneous storage media (e.g., memory, SSDs, HDDs, NAS) with different capacities and performance characteristics. The system offers a variety of pluggable policies for automating data management across the storage tiers and cluster nodes. The policies employ multi-objective optimization techniques for making intelligent data management decisions based on the requirements of fault tolerance, data and load balancing, and throughput maximization. At the same time, the storage media are explicitly exposed to users and applications, allowing them to choose the distribution and placement of replicas in the cluster based on their own performance and fault tolerance requirements. Our extensive evaluation shows the immediate benefits of using OctopusFS with data-intensive processing systems, such as Hadoop and Spark, in terms of both increased performance and better cluster utilization.
Negotiating styles adopted by consultant psychiatrists when prescribing antipsychotics

A good therapeutic alliance between mental health professionals and patients with psychosis can enhance adherence to medication regimens and improve clinical outcome. This article explores how the therapeutic alliance might be developed with respect to decisions to prescribe antipsychotic medication. It does this by presenting the implications for practice that arise from a recent qualitative interview study with consultant psychiatrists. We consider strategies for strengthening the therapeutic alliance, occasions when it might be appropriate to suspend shared decision-making temporarily, techniques used to enable discussion of symptoms and side-effects, and how issues of adherence are uncovered and addressed. Psychiatrists already possess considerable skills in these areas. The dissemination of these to colleagues forms an important opportunity for CPD.
Clinical Value of Serum Soluble CD30 Levels in Adult T-Cell Leukemia/Lymphoma

Adult T-cell leukemia/lymphoma (ATLL) is an incurable neoplasm of mature T-cells with a median survival time of approximately one year. The aim of this study was to compare the clinical value of soluble CD30 (sCD30) levels with soluble IL-2 receptor α chain (sIL-2R) levels in two different clinical settings of ATLL patients; before an initial therapy of chemotherapy or gastric resection (n=32), and before allogeneic hematopoietic stem cell transplantation (HSCT; n=24). All patients completed the 2-year follow-up. Both sIL-2R (p=0.016) and sCD30 (p=0.030) levels were significant predictors of overall survival before the initial therapy. The number of ATLL cells in peripheral blood (PB) was correlated with sCD30 levels (Spearman’s correlation coefficient, ρ=0.46; p=0.009) but not with sIL-2R levels (ρ=0.16; P=0.38). Patients who survived for longer than two years, and for whom the percentage of ATLL cells in PB were <5%, displayed relatively low sCD30 levels, but this tendency for low sCD30 levels was not observed in longterm survivors whose ATLL cells constituted ≥5% of PB cells. sIL-2R (p=0.041) and sCD30 (p=0.0003) values were both significant predictors of overall survival in HSCT, but sCD30 levels predicted more patients with early death than were predicted by sIL-2R levels. Combination of sCD30 and CRP levels showed high sensitivity and specificity for detection of early death (within 100 days) following HSCT (81.8% and 84.6%, respectively). These results suggest that analysis of sCD30 levels may be useful for prediction of overall survival in ATLL patients, especially before HSCT. These findings would alter the treatment strategy and improve the prognosis of ATLL.
KNOWLEDGE AND ATTITUDES RELATED TO HIV/AIDS AMONG MEDICAL AND ALLIED HEALTH SCIENCES STUDENTS

Background: India estimates third highest number of HIV infections in the world, with about 2.4 million people currently living with HIV/AIDS. Adequately trained and sensitized healthcare professionals can play a vital role in combating this epidemic. Limited studies have explored knowledge and attitudes of medical students relating to HIV/AIDS, particularly in the eastern part of India. Methods: The present cross sectional study explored knowledge and attitudes of first year MBBS, BDS & BPT students of Kalinga Institute of Medical Sciences (KIMS), Bhubaneswar, Odisha on HIV/AIDS using a self-administered questionnaire. Data thus collected were analyzedand relevant statistics were calculated. Knowledge and attitude scores were determined and analysis of variance (ANOVA) test was used to examine the equality between the groups. Results: All students scored low on the overall knowledge scale (<10/15). Specifically, knowledgewas low on modes of transmission and treatment. Attitudinal scores in the areas of precautions and need for training on HIV was low for all the three streams.The willingness to treat HIV/AIDS patient was found to be high amongst study participants. Conclusion: There is a need and scope to provide correct and detailed information on HIV/AIDS for new entrants in medical and allied health sciences to help them acquire adequate knowledge and develop appropriate attitudes towards HIV/AIDS.
Class Attendance and Academic Performance among Spanish Economics Students

This paper presents new evidence on the effects of class attendance on academic performance. We analyse survey data collected for an Introductory Econometrics Course at the Facultad de Ciencias Sociales y Juridicas of Universidad Carlos III de Madrid, matched to administrative data. Using OLS-proxy regressions to control for unobservable student characteristics potentially correlated with attendance, we find a positive and significant effect of attendance on academic performance. However, the fact that instrumental variable regressions may be failing to account for the correlation not captured by the controls calls for further investigation based on panel data.
Inverse Association of Serum Adiponectin Level with Body Mass Index in Peritoneal Dialysis Patients

BACKGROUND: Body mass index (BMI) is negatively correlated with adiponectin level in the general population. The aim of this study was to investigate the relationships of fasting serum adiponectin levels and the anthropometric components among peritoneal dialysis (PD) patients.METHODS: Fasting blood samples were obtained from 40 PD patients. Fasting adiponectin levels were measured using a commercial enzyme-linked immunosorbent assay kit.RESULTS: Univariate linear regression analysis results showed that body weight (r = -0.451; P = 0.003), waist circumference (r = -0.351; P = 0.026), BMI (r = -0.547; P ＜ 0.001), body fat mass (r = -0.370; P = 0.019), white blood count (WBC; r = -0.584; P ＜ 0.001), triglyceride (TG; r = -0.550; P ＜ 0.001), fasting glucose (r = -0.349; P ＜ 0.027), c-reactive protein (CRP; r = -0.340; P = 0.032), triceps skinfold (TSF; r = -0.427; P = 0.006), mid-arm circumference (MAC; r = -0.335; P = 0.034), and mid-arm fat area (MAFA; r = -0.446; P ＜ 0.001) were negatively correlated with fasting serum adiponectin levels, whereas highdensity lipoprotein cholesterol (HDL-C; r = 0.607; P ＜ 0.001) was positively correlated with fasting serum adiponectin levels in PD patients. Multivariate forward stepwise linear regression analysis of the significant variables showed that the HDL (R2 change = 0.368, P = 0.005) and BMI (R2 change = 0.159, P = 0.001) were independent predictors of fasting serum adiponectin levels. BMI cut-off points (underweight, normal, overweight, and obesity) were also inversely associated with serum adiponectin levels in PD patients (P = 0.001). CONCLUSIONS: Fasting adiponectin level was inversely associated with BMI among PD patients.
Functional evaluation of hydronephrosis by diffusion-weighted MR imaging: Relationship between apparent diffusion coefficient and split glomerular filtration rate

Purpose: To determine the relationship between apparent diffusion coefficient (ADC) values measured by diffusion-weighted MR imaging and split renal function determined by renal scintigraphy in patients with hydronephrosis. Material and Methods: Diffusion-weighted imaging on a 1.5 T MR unit and renal scintigraphy were performed in 36 patients with hydronephrosis (45 hydronephrotic kidneys, 21 non-hydronephrotic kidneys). ADC values of the individual kidneys were measured by diffusion-weighted MR imaging. Split renal function (glomerular filtration rate (GFR)) was determined by renal scintigraphy using 99mTc-DTPA. The relationship between ADC values and split GFR was examined in 66 kidneys. The hydronephrotic kidneys were further classified into three groups (severe renal dysfunction, GFR <10 ml/min, n=7; moderate renal dysfunction, GFR 10-25 ml/min, n=10; normal renal function, GFR >25 ml/min, n=28), and mean values for ADCs were calculated. Results: In hydronephrotic kidneys, there was a moderate positive correlation between ADC values and split GFR (R2=0.56). On the other hand, in non-hydronephrotic kidneys, poor correlation between ADC values and split GFR was observed (R2=0.08). The mean values for ADCs of the dysfunctioning hydronephrotic kidneys (severe renal dysfunction, 1.32×10-3±0.18×10-3 mm2/s; moderate renal dysfunction, 1.38×10-3±0.10×10-3 mm2/s) were significantly lower than that of the normal functioning hydronephrotic kidneys (1.63×10-3±0.12±10-3 mm2/s). Conclusion: These results indicated that measurement of ADC values by diffusion-weighted MR imaging has a potential value in the evaluation of the functional status of hydronephrotic kidneys.
Sarcocystis jamaicensis n. sp., from Red-Tailed Hawks (Buteo jamaicensis) Definitive Host and IFN-γ Gene Knockout Mice as Experimental Intermediate Host

Abstract Here, we report a new species of Sarcocystis with red-tailed hawk (RTH, Buteo jamaicensis) as the natural definitive host and IFN-γ gene knockout (KO) mice as an experimental intermediate host in which sarcocysts form in muscle. Two RTHs submitted to the Carolina Raptor Center, Huntersville, North Carolina, were euthanized because they could not be rehabilitated and released. Fully sporulated 12.5 × 9.9-μm sized sporocysts were found in intestinal scrapings of both hawks. Sporocysts were orally fed to laboratory-reared outbred Swiss Webster mice (SW, Mus musculus) and also to KO mice. The sporocysts were infective for KO mice but not for SW mice. All SW mice remained asymptomatic, and neither schizonts nor sarcocysts were found in any SW mice euthanized on days 54, 77, 103 (n = 2) or 137 post-inoculation (PI). The KO mice developed neurological signs and were necropsied between 52 to 68 days PI. Schizonts/merozoites were found in all KO mice euthanized on days 52, 55 (n = 3), 59, 61 (n = 2), 66, and 68 PI and they were confined to the brain. The predominant lesion was meningoencephalitis characterized by perivascular cuffs, granulomas, and necrosis of the neural tissue. The schizonts/merozoites were located in neural tissue and were apparently extravascular. Brain homogenates from infected KO mice were infective to KO mice by subcutaneous inoculation and when seeded on to CV-1 cells. Microscopic sarcocysts were found in skeletal muscles of 5 of 8 KO mice euthanized between 55–61 days PI. Only a few sarcocysts were detected. Sarcocysts were microscopic, up to 3.5 mm long. When viewed with light microscopy, the sarcocyst wall appeared thin (<1 μm thick) and smooth. By transmission electron microscopy, the sarcocyst wall classified as “type 1j” (new designation). Molecular characterization using 18S rRNA, 28S rRNA, ITS-1, and cox1 genes revealed a close relationship with Sarcocystis microti and Sarcocystis glareoli; both species infect birds as definitive hosts. The parasite in the present study was biologically and molecularly different from species so far described in RTHs and we therefore propose a new species name, Sarcocystis jamaicensis n. sp.
Prevalence of drug use prior to detention among residents of youth detention centres in Queensland

Research into juvenile delinquency has established a strong connection between delinquent behaviour and drug usage. Anecdotal evidence suggests that a number of young people coming into detention in Queensland are suffering physical, behavioural and emotional consequences of their drug use prior to detention. Between December 1995 and January 1996, a total of 118 young people in detention were surveyed regarding their drug use behaviour prior to detention. This represented 90% of the average total population in detention. The average age of the sample was 15.6 years; 90% were males. Over 90% of the population had used (or at least tried) pain relievers, other medicines, cannabis, alcohol and tobacco. The use of the so called 'hard drugs' was high, with 47% having tried amphetamines, 35% admitting to having tried heroin, and 64% having used hallucinogens at least once. Data regarding harm-minimization practices revealed that 42% had injected drugs and of these half had shared a needle at least once, while .
New Cystidicolid Species (Nematoda) From Galaxias platei (Osmeriformes: Galaxiidae) in Patagonian Freshwater Environments

During a parasitological survey of Galaxias platei Steindachner, 1898, from Patagonian Andean Lakes, a new species of Cystidicolidae was found in the stomach of fish. The new species was described using light and scanning electron microscopy; the species has characteristics of Ascarophis and is distinguishable from other species by a combination of the following features: well-developed pseudolabia with T-shaped inner extensions, bifurcate deirids, small ratio GE:ME, small left spicule, small ratio LS:RS, and larvigerous eggs with thick and fine filaments in both poles. Intraspecific variation in the morphology of larvigerous eggs was studied. This is the first species of Ascarophis described from freshwater fishes.
Financial Literacy Teacher Training: A Multiple-Measure Evaluation

This study evaluates a two-day train the trainer program designed to provide instructors from diverse backgrounds with the tools needed to teach financial literacy to individual debtors. Trained teachers reported satisfaction with their training and felt prepared to teach; they also provided constructive feedback. Pre- and post-test questionnaires reveal a 9% increase in financial knowledge and positive changes in attitude. Observations reveal that skills learned in training transferred to desired teaching behavior in the classroom. This paper addresses the implications of our findings for both the training literature and the implementation and operation of the recently passed 2005 bankruptcy legislation.
Design and Evaluation of an RDMA-aware Data Shuffling Operator for Parallel Database Systems

The commoditization of high-performance networking has sparked research interest in the RDMA capability of this hardware. One-sided RDMA primitives, in particular, have generated substantial excitement due to the ability to directly access remote memory from within an application without involving the TCP/IP stack or the remote CPU. This paper considers how to leverage RDMA to improve the analytical performance of parallel database systems. To shuffle data efficiently using RDMA, one needs to consider a complex design space that includes (1) the number of open connections, (2) the contention for the shared network interface, (3) the RDMA transport function, and (4) how much memory should be reserved to exchange data between nodes during query processing. We contribute six designs that capture salient trade-offs in this design space. We comprehensively evaluate how transport-layer decisions impact the query performance of a database system for different generations of InfiniBand. We find that a shuffling operator that uses the RDMA Send/Receive transport function over the Unreliable Datagram transport service can transmit data up to 4× faster than an RDMA-capable MPI implementation in a 16-node cluster. The response time of TPC-H queries improves by as much as 2×.