Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Influencing the Selection of Hotels/Resorts in Lanta Yai Island, Krabi, Thailand by International Travelers

The objectives of this study are to investigate and identify important factors of hotel/resort selection for International Travelers. The aim is to study the influencial factors involving decision-making in selection of accommodations in Lanta Yai Island, Krabi, Thailand. The samples in this study were a group of International travelers who traveled and stayed in Lanta Yai Island during in April 2011. Some 200 sets of questionnaires were used at Lanta Yai Island. The tool used in this research was the questionnaire developed by the author. The data was then analyzed by a factor analysis with Orthogonal and VARIMAX rotation. The results of the study about the factors influencing international tourists in the selection of hotels/resorts indicated that ‘Security and Safety’ was the most important factor. ‘Value’ was ranked as the second most important factor, followed by ‘Staff Service Quality’, ‘Location’, and ‘Room and facilities Quality’, respectively. The study suggested that ‘Security and Safety’ has been identified as the most influential in determining customers’ selecting the hotel in Lanta Yai Island, this is what hotels in Lanta Yai Island should consider while developing marketing strategies. For these prospective customers, security and safety are the most basic human needs. Even if the hotel is comfortable, if there is no safety, it is not worthwhile staying there. The other factors such as ‘Value’, ‘Staff Service Quality’, ‘Location’ and ‘Room and Facilities should not be ignored as well. The hoteliers should maintain the standards of these services and facilities to meet the basic needs of the customers.
Momentum transport processes in the stratiform regions of mesoscale convective systems over the western Pacific warm pool

Momentum transport by the stratiform components of mesoscale convective systems (MCSs) during the Tropical Ocean–Global Atmosphere Coupled Ocean–Atmosphere Response Experiment in December 1992 is investigated using a cloud‐resolving model. The mesoscale momentum transport by the stratiform regions of MCSs is examined in two distinct large‐scale flow regimes associated with the intraseasonal oscillation over the western Pacific warm pool. Model simulations for 14 December 1992 characterize the ‘westerly onset’ period, which has relatively weak low‐level westerlies with easterlies above. Simulations for 23–24 December represent the ‘strong westerly’ regime, when westerlies extend from the upper troposphere to the surface, with a jet 2–3 km above the surface. In the westerly onset simulation, the extensive stratiform region of a MCS contained a broad region of descent that transported easterly momentum associated with the mid‐level easterly jet downward. Thus, the stratiform regions acted as a negative feedback to decrease the large‐scale mean westerly momentum developing at low levels. In the strong westerly regime, the mesoscale downward air motion in the stratiform regions of large MCSs transported westerly momentum downward and thus acted as a positive feedback, strengthening the already strong westerly momentum at low levels. Momentum fluxes by the mesoscale stratiform region downdraughts are shown to have a systematic and measurable impact on the large‐scale momentum budget. Copyright © 2006 Royal Meteorological Society.
Quality of life and depressive symptoms in Parkinson's disease.

we have recently used the 39-item Parkinson’s Disease Questionnaire (PDQ-39) and its eight dimensions and the 15-item GDS (GDS-15) to assess quality of life and depressive symptoms in PD patients, respectively. We divided the patients into two groups (PD without depression and PD with depression) according to the GDS-15 cutoff score of eight proposed for the screening of depression in PD.
The changing profile of nursing home residents: 1985-1997.

• Demand for nursing home and other health-care services for the eldely will increase significantly as the baby-boomers age, presenting formidable challenges. Overview Nursing homes are an important component of health services for the elderly population. Specifically, nursing homes or skilled nursing facilities provide 24-hour nursing care to sick or disabled individuals who do not require expensive inpatient hospital services, but cannot be cared for at home through home health care or other community options. Patients who have been critically ill or have undergone surgery will often be admitted to a nursing home for a short stay until they are well enough to return to the community. Other short stay residents may be too ill to be cared for at home and will enter the nursing home for a short period before death. Some patients admitted to nursing homes are not acutely ill, but are too disabled to care for themselves. These patients may have had family or other informal caregivers who could no longer care for them as cognitive impairment, incontinence, or other disabilities worsened. These residents may remain in the nursing home for a longer stay, perhaps years.
Transcription unit mapping in adenovirus: regions of termination

Using a series of single-stranded clones of adenovirus DNA, we determined the extent of RNA polymerase II transit early in infection for two rightward-reading transcription units. RNA synthesis beginning at the major late promoter (16.5 on the genomic map) continued until approximately 65 to 70 map units so that differential choices of mRNAs within that region were not based primarily on transcriptional decisions but rather on posttranscriptional decisions. Transcription from the major late promoter beginning at 16.5 map units, however, did greatly decrease before approximately 75 map units, ensuring that no mRNAs were formed with sequences beyond approximately 75 map units. Early transcription from E3 then began just past 75 map units (at a higher rate than transcription from the major late promoter); E3 transcripts terminated at least 2 kilobases downstream from a second and final poly(A) site in this transcription unit. The effectiveness of termination in E3 was greater than 95 to 99%.
The Impact of Entry on Prices and Costs

In this article, we propose a very simple methodology to evaluate the impact on prices and costs of the entry of a firm in a market, and apply it to the entry of a third firm in the Portuguese mobile telephony industry. Using quarterly firm level data, we characterize the evolution of the firms' prices and costs. We argue that the more plausible explanation for the behavior of these variables is the competition hypothesis. The entry of the third firm forced the other two firms to reduce their prices. The decrease in their profit margins led the two firms to improve their internal efficiency. As a consequence, their costs fell.
Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells

Mucin 1 (MUC1) is a diagnostic factor and therapy target in lung adenocarcinoma. MUC1 C-terminal intracellular domain (CD) interacts with estrogen receptor (ER) α and increases gene transcription in breast cancer cells. Because lung adenocarcinoma cells express functional ERα and ERβ, we examined MUC1 expression and MUC1–ER interaction. Because blocking MUC1 CD with an inhibitory peptide (PMIP) inhibited breast tumor growth, we tested whether PMIP would inhibit lung adenocarcinoma cell proliferation. We report that MUC1 interacts with ERα and ERβ within the nucleus of H1793 lung adenocarcinoma cells in accordance with MUC1 expression. PMIP was taken up by H23 and H1793 cells and inhibited the proliferation of H1793, but not H23 cells, concordant with higher MUC1 protein expression in H1793 cells. Lower MUC1 protein expression in H23 does not correspond to microRNAs miR-125b and miR-145 that have been reported to reduce MUC1 expression. PMIP had no effect on the viability of normal human bronchial epithelial cells, which lack MUC1 expression. PMIP inhibited estradiol-activated reporter gene transcription and endogenous cyclin D1 and nuclear respiratory factor-1 gene transcription in H1793 cells. These results indicate MUC1–ER functional interaction in lung adenocarcinoma cells and that inhibiting MUC1 inhibits lung adenocarcinoma cell viability. Mol Cancer Ther; 10(11); 2062–71. ©2011 AACR.
Does clinical experience help oncology nursing staff to deal with patient pain better than nurses from other displines? Knowledge and attitudes survey amongst nurses in a tertiary care in Malaysia.

BACKGROUND Successful implementation of pain management procedures and guidelines in an institution depends very much on the acceptance of many levels of healthcare providers. AIM The main purpose of this study was to determine the level of knowledge and attitudes regarding pain among nurses working in tertiary care in a local setting and the factors that may be associated with this. MATERIALS AND METHODS This cross-sectional research study used a modified version of the Nurses' Knowledge and Attitudes Survey (NKAS) regarding pain. Basic demographic data were obtained for further correlation with the level of pain knowledge. RESULTS A total of 566 nurses, 34 male and 532 female, volunteered to participate in this study. The response rate (RR) was 76%, with an overall mean percentage score of 42.7±10.9 (range: 5-92.5). The majority of participants were younger nurses below 40 years of age and more than 70% had worked for less than 10 years (6.6±4.45). Up to 92% had never had any formal education in pain management in general. The total mean score of correct answers was 58.6±9.58, with oncology nursing staff scoring a higher percentage when compared with nurses from other general and critical care wards (63.52±9.27, p<0.045). Only 2.5% out of all participants obtained a score of 80% or greater. The majority of the oncology nurses achieved the expected competency level (p<0.03). CONCLUSIONS The present findings give further support for the universal concern about poor knowledge and attitudes among nurses related to the optimal management of pain. The results indicated that neither number of years working nor age influenced the level of knowledge or attitudes of the practising nurses. Oncology nursing staff consistently scored better than the rest of the cohort. This reflects that clinical experience helps to improve attitudes and knowledge concerning better pain management.
Efficacy and safety of formoterol turbuhaler® when added to inhaled corticosteroid treatment in children with asthma

This double‐blind, placebo‐controlled, randomized, parallel‐group, multicenter study was conducted in 302 children aged 6–11 years with asthma not optimally treated with inhaled corticosteroids alone. Patients continued with their existing dose of inhaled corticosteroids and in addition received placebo, formoterol 4.5 μg or formoterol 9 μg b.i. d. , for 12 weeks (all delivered via Turbuhaler®). Terbutaline was available as reliever medication. The primary efficacy variable was change from baseline in morning peak expiratory flow (PEF); secondary efficacy variables included forced expiratory volume in 1 sec (FEV1), serial PEF measured over 12 hr, evening PEF, asthma symptom score, and quality of life. Compared with placebo, formoterol 4.5 μg and 9 μg improved morning PEF by 8 l/min (P = 0.035) and 11 l/min (P = 0.0045), respectively. Evening PEF and FEV1 were also significantly increased compared with placebo, with no statistically significant difference between formoterol doses. Lung‐function improvements compared with placebo were greater in the middle of the day. Twelve‐hour average serial PEF after 3 months increased by 24 l/min (95% CI, 9, 39 l/min) in the formoterol 9‐μg group, and by 14 l/min (95% CI, 0, 29 l/min) in the formoterol 4.5‐μg group. The incidence of severe exacerbations in both formoterol groups was numerically lower than in the placebo group, indicating that formoterol may have the potential to improve exacerbation control in children. Both formoterol doses were well‐tolerated, and tolerance to the drug's bronchodilator effect was not observed. Formoterol provided sustained improvements in lung function and was well‐tolerated in children with asthma suboptimally treated with inhaled corticosteroids alone. Pediatr Pulmonol. 2004; 37:122–127. © 2004 Wiley‐Liss, Inc.
Hearing Status in Adult Individuals with Lifetime, Untreated Isolated Growth Hormone Deficiency

Objective To evaluate the hearing status of growth hormone (GH)–naive adults with isolated GH deficiency (IGHD) belonging to an extended Brazilian kindred with a homozygous mutation in the GH-releasing hormone receptor gene. Study Design Cross-sectional. Setting Divisions of Endocrinology and Otorhinolaryngology of the Federal University of Sergipe. Subjects and Methods Twenty-six individuals with IGHD (age, 47.6 ± 15.1 years; 13 women) and 25 controls (age, 46.3 ± 14.3 years; 15 women) were administered a questionnaire on hearing complaints and hearing health history. We performed pure-tone audiometry, logoaudiometry, electroacoustic immittance, and stapedial reflex. To assess outer hair cell function in the cochlea, we completed transient evoked otoacoustic emissions (TEOAEs). To assess the auditory nerve and auditory brainstem, we obtained auditory brainstem responses (ABRs). Results Misophonia and dizziness complaints were more frequent in those with IGHD than in controls (P = .011). Patients with IGHD had higher thresholds at 250 Hz (P = .005), 500 Hz (P = .006), 3 KHz (P = .008), 4 KHz (P = .038), 6 KHz (P = .008), and 8 KHz (P = .048) and mild high-tones hearing loss (P = .029). Stapedial reflex (P < .001) and TEOAEs (P = .025) were more frequent in controls. There were no differences in ABR latencies. Hearing loss in patients with IGHD occurred earlier than in controls (P < .001). Conclusion Compared with controls of the same area, subjects with untreated, congenital lifetime IGHD report more misophonia and dizziness, have predominance of mild high-tones sensorineural hearing loss, and have an absence of stapedial reflex and TEOAEs.
In Situ Observation of Compliance-Current Overshoot and Its Effect on Resistive Switching

The compliance-current dependence of the resistive-switching behaviors is investigated in TaN/Cu<i>x</i>O/Cu memory devices with 1R architecture and 1T1R architecture, respectively. The correlation of reset current <i>I</i> <sub>reset</sub> and on-state resistance <i>R</i> <sub>on</sub> can be verified by adjusting the compliance current <i>I</i> <sub>comp</sub>. Meanwhile, <i>I</i> <sub>reset</sub> and <i>R</i> <sub>on</sub> become independent on <i>I</i> <sub>comp</sub> in the 1R architecture when <i>I</i> <sub>comp</sub> is below 1 mA. A serious compliance-current overshoot phenomenon is <i>in situ</i> observed in 1R-architecture device, and it remarkably affects the resistive-switching characteristics because the compliance current dominates the memory behaviors. Therefore, resistive-switching investigation based on 1T1R architecture is much more reliable.
Use of AlloDerm implant to prevent frey syndrome after parotidectomy.

OBJECTIVE To evaluate the effectiveness of AlloDerm, an acellular human dermal matrix graft, as an interpositional physical barrier to prevent the development of Frey syndrome after parotidectomy. METHODS The 30 patients included in the study were divided into 3 groups of 10. In group 1 (study group), patients underwent superficial parotidectomy with placement of an AlloDerm graft (LifeCell Corp, Branchburg, NJ). In group 2 (control) patients had superficial parotidectomy without placement of an interpositional barrier. In group 3 (control), patients underwent deep-plane rhytidectomy without disruption of the parotid fascia. All were evaluated after 1 year and questioned about gustatory sweating. Subjective assessment of Frey syndrome was documented when patients experienced gustatory sweating, even if they were not perturbed by the symptom. The Minor starch-iodine test was performed in each patient for objective assessment. RESULTS The incidence of subjective Frey syndrome was observed in 1 patient in group 1 and 5 patients in group 2. The incidence of objective Frey syndrome was noted in 2 patients in group 1 and 8 patients in group 2. Both subjective and objective differences in incidence of Frey syndrome were statistically significant. None of the group 3 patients had subjective or objective Frey syndrome. Two patients in group 1 and 3 patients in group 2 developed a transient seroma or sialocele that resolved with conservative management. CONCLUSION The use of AlloDerm graft as an interpositional barrier improves parotidectomy outcome by reducing the incidence of Frey syndrome.
Intraocular lens short wavelength light filtering

There is increasing interest in the effects of reactive oxygen species (‘free radicals’) in ageing, both in the body overall and specifically in the eye. Cataract and age‐related macular degeneration (AMD) are two major causes of blindness, with cataract accounting for 48 per cent of world blindness and AMD accounting for 8.7 per cent. Both cataract and AMD affect an older population (over 50 years of age) and while cataract is largely treatable provided resources are available, AMD is a common cause of untreatable, progressive visual loss. There is evidence that AMD is linked to exposure to short wavelength electromagnetic radiation, which includes ultraviolet, blue and violet wavelengths. The ageing crystalline lens provides some protection to the posterior pole because, as it yellows with age, its spectral absorption increasingly blocks the shorter wavelengths of light. Ultraviolet blocking intraocular lenses (IOLs) have been the standard of care for many years but a more recent trend is to include blue‐blocking filters based on theoretical benefits. As these filters absorb part of the visible spectrum, they may affect visual function. This review looks at the risks and the benefits of filtering out short wavelength light in pseudophakic patients.
Oxygen Uptake Kinetics Is Slower in Swimming Than Arm Cranking and Cycling during Heavy Intensity

Oxygen uptake (V·O2) kinetics has been reported to be influenced by the activity mode. However, only few studies have compared V·O2 kinetics between activities in the same subjects in which they were equally trained. Therefore, this study compared the V·O2 kinetics response to swimming, arm cranking, and cycling within the same group of subjects within the heavy exercise intensity domain. Ten trained male triathletes (age 23.2 ± 4.5 years; height 180.8 ± 8.3 cm; weight 72.3 ± 6.6 kg) completed an incremental test to exhaustion and a 6-min heavy constant-load test in the three exercise modes in random order. Gas exchange was measured by a breath-by-breath analyzer and the on-transient V·O2 kinetics was modeled using bi-exponential functions. V·O2peak was higher in cycling (65.6 ± 4.0 ml·kg−1·min−1) than in arm cranking or swimming (48.7 ± 8.0 and 53.0 ± 6.7 ml·kg−1·min−1; P < 0.01), but the V·O2 kinetics were slower in swimming (τ1 = 31.7 ± 6.2 s) than in arm cranking (19.3 ± 4.2 s; P = 0.001) and cycling (12.4 ± 3.7 s; P = 0.001). The amplitude of the primary component was lower in both arm cranking and swimming (21.9 ± 4.7 and 28.4 ± 5.1 ml·kg−1·min−1) compared with cycling (39.4 ± 4.1 ml·kg−1·min−1; P = 0.001). Although the gain of the primary component was higher in arm cranking compared with cycling (15.3 ± 4.2 and 10.7 ± 1.3 ml·min−1·W−1; P = 0.02), the slow component amplitude, in both absolute and relative terms, did not differ between exercise modes. The slower V·O2 kinetics during heavy-intensity swimming is exercise-mode dependent. Besides differences in muscle mass and greater type II muscle fibers recruitment, the horizontal position adopted and the involvement of trunk and lower-body stabilizing muscles could be additional mechanisms that explain the differences between exercise modalities.
CLINICAL IMPLICATIONS OF THE p 53 GENE

The capacity for malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth and tissue homeostasis. Although several hundred genes are known to control growth, molecular genetic studies in cancer show that few of these are consistently involved in the natural history of human cancer, and those typically in only certain types of malignancy. Prospects for development of molecular-based diagnostic and therapeutic strategies with widespread application did not look promising, until it was realized that the p53 tumor suppressor gene was defective in approximately half of all malignancies. This discovery generated research efforts of unparalleled intensity to determine how p53 functions at the molecular level, and how to apply this knowledge to clinical ends. FUNCTIONS OF NORMAL p53 The term p53 originally referred to a 53-kilodalton phosphoprotein, the product of a 20-kilobase gene on the short arm of human chromosome 17. However, both the gene (tumor protein 53, or TP53) and the protein were designated as p53 on the historical grounds that the protein was discovered (1, 2) well before the gene and that it plays a critical role as a cancer suppressor (3, 4). Normal (wild-type) p53 suppresses outgrowth of genetically damaged, hence potentially neoplastic, cells in two distinct ways: by causing a pause in the cell cycle, and by promoting exit from the cell cycle altogether (programmed cell death, or apoptosis). This dichotomy is thought to allow an appropriate biological response to the two sequelae of DNA damage: Either genome integrity is restored by DNA repair, in which case cells can be released from transient cell cycle arrest, or when damage persists, cells can be permanently eliminated from the population by apoptosis. This function of p53 as “guardian of the genome” may extend to a role in initial monitoring and repair of DNA damage in addition to direct control of cell growth and death (5,
Competition in the Brazilian loan market: an empirical analysis

The aim of this paper is to review some of the existing tests for competition in Brazilian banking, as well as to propose an alternative. After the description of the institutional setting of the Brazilian Banking system on this period, the competition tests on the literature were reviewed, beginning with the test proposed by Panzar and Rosse (1987). The market does not seem to be in long-run equilibrium, implying only the market does not seem to find itself in collusive outcome. The next step was to try a new methodology, applied by Moreno, Martinez and Ruiz (2006) for the Spanish banking market. On this methodology, in which the assumption of equality of conduct parameters between firms and time periods is relaxed, the results indicate that, for some firms and in some time periods, a cooperative conduct in fact is present.
ON CHEMICALLY ROUGH BOUNDARY

We study the interface dynamics and contact angle hysteresis in a two dimensional, chemically patterned channel described by the Cahn-Hilliard equation with a relaxation boundary condition. A system for the dynamics of the contact angle and contact point is derived in the sharp interface limit. We then analyze the behavior of the solution using the phase plane analysis. We observe the stick-slip of the contact point and the contact angle hysteresis. As the size of the pattern decreases to zero, the stick-slip becomes weaker but the hysteresis becomes stronger in the sense that one observes either the advancing contact angle or the receding contact angle without any switching in between. Numerical examples are presented to verify our analysis. Dedicated to the memory of Paul Fife