Miracle-dz/UniFAR-FTUs huggingface dataset:
Diana Evans in conversation

fBrnmtilb® §®nm * Diana Evans was born in Neasden, I London in 1972. A graduate of the { creative writing MA at the University J of East Anglia, she went on to publish short stories in a number of anthologies. Evans is the only British authorto be short-listed for the first £10,000 Orange Award for New Writers, in 2005; she was nominated for her debut novel 26a. She has worked as a journalist for Marie Claire, the Evening Standard, Pride magazine and writes regularly forThe Independent and Stage. This interview with Bernardine Evaristo took place in Diana's West London home in January 2005, while her baby, all of three weeks old, slept soundly in the next room. Wasafiri published an extract of this novel, in a much earlier and now defunct draft, in its 'Black Writing in Britain' issue (no 29, Spring 1999). The novel has now received much critical acclaim and has been heralded as one of the most significant works of fiction by a new writer this year. 26a Is about identical twins, Bessi and Georgia, who live in the loft of 26 Waifer Avenue in Neasden. There's an older sister Bel and a younger sister Kemy, as well as their parents, Ida who is Nigerian and Aubrey, who is a white Englishman. The novel follows the twins'trajectory through their childhood, part of which is spent in Nigeria, and into an adulthood which sees their magical, bonded world coming apart and being replaced by the challenges of independence and early adulthood.
Overexpression of an Arabidopsis thaliana galactinol synthase gene improves drought tolerance in transgenic rice and increased grain yield in the field

Abstract Drought stress has often caused significant decreases in crop production which could be associated with global warming. Enhancing drought tolerance without a grain yield penalty has been a great challenge in crop improvement. Here, we report the Arabidopsis thaliana galactinol synthase 2 gene (AtGolS2) was able to confer drought tolerance and increase grain yield in two different rice (Oryza sativa) genotypes under dry field conditions. The developed transgenic lines expressing AtGolS2 under the control of the constitutive maize ubiquitin promoter (Ubi:AtGolS2) also had higher levels of galactinol than the non‐transgenic control. The increased grain yield of the transgenic rice under drought conditions was related to a higher number of panicles, grain fertility and biomass. Extensive confined field trials using Ubi:AtGolS2 transgenic lines in Curinga, tropical japonica and NERICA4, interspecific hybrid across two different seasons and environments revealed the verified lines have the proven field drought tolerance of the Ubi:AtGolS2 transgenic rice. The amended drought tolerance was associated with higher relative water content of leaves, higher photosynthesis activity, lesser reduction in plant growth and faster recovering ability. Collectively, our results provide strong evidence that AtGolS2 is a useful biotechnological tool to reduce grain yield losses in rice beyond genetic differences under field drought stress.
Return-to-work rehabilitation programs for musculoskeletal pain and common mental health disorders : Study protocol of a randomized controlled trial

1Department of Public Health and General Practice, Faculty of Medicine, Nor wegian University of Science and Technology, Trondheim, Norway. 2 Hysnes Rehabilitation Center, St. Olavs University Hospital, Trondheim, Norwa y 3 Department of Physical Medicine and Rehabilitation, St. Olav University Hos pital, Trondheim, Norway. 4 Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegia n University of Science and Technology, Trondheim, Norway.
Gender Differences in Japanese Conversation

The present study aims to explore the differences between the interaction styles of Japanese men and women. The study specifically examines three interactional patterns as seen in a Japanese talk/variety show: interruptions, reactions to interruptions, and backchannels. The data are analyzed both quantitatively and qualitatively. In the quantitative analysis, interruptions, reactions to interruptions, and backchannels are identified from the excerpts and categorized. In the qualitative analysis, the context of these various interruptions is closely examined, and the functions of interruptions are probed. The results are discussed following the implications.
Time-Dependent Interaction between Differentiated Embryo Chondrocyte-2 and CCAAT/Enhancer-Binding Protein α Underlies the Circadian Expression of CYP2D6 in Serum-Shocked HepG2 Cells

Differentiated embryo chondrocyte-2 (DEC2), also known as bHLHE41 or Sharp1, is a pleiotropic transcription repressor that controls the expression of genes involved in cellular differentiation, hypoxia responses, apoptosis, and circadian rhythm regulation. Although a previous study demonstrated that DEC2 participates in the circadian control of hepatic metabolism by regulating the expression of cytochrome P450, the molecular mechanism is not fully understood. We reported previously that brief exposure of HepG2 cells to 50% serum resulted in 24-h oscillation in the expression of CYP3A4 as well as circadian clock genes. In this study, we found that the expression of CYP2D6, a major drug-metabolizing enzyme in humans, also exhibited a significant oscillation in serum-shocked HepG2 cells. DEC2 interacted with CCAAT/enhancer-binding protein (C/EBPα), accompanied by formation of a complex with histone deacetylase-1, which suppressed the transcriptional activity of C/EBPα to induce the expression of CYP2D6. The oscillation in the protein levels of DEC2 in serum-shocked HepG2 cells was nearly antiphase to that in the mRNA levels of CYP2D6. Transfection of cells with small interfering RNA against DEC2 decreased the amplitude of CYP2D6 mRNA oscillation in serum-shocked cells. These results suggest that DEC2 periodically represses the promoter activity of CYP2D6, resulting in its circadian expression in serum-shocked cells. DEC2 seems to constitute a molecular link through which output components from the circadian clock are associated with the time-dependent expression of hepatic drug-metabolizing enzyme.
The association of dietary folate, B6, and B12 with cardiovascular mortality in Spain: an ecological analysis.

OBJECTIVES This study assessed the association of dietary folate, vitamin B6, and vitamin B12 with cardiovascular mortality. METHODS Poisson regression analyses assessed coronary/cerebrovascular mortality rates via nutrient data obtained from the National Nutrition Survey, which recorded 7-day food intakes from a national sample of 21,155 households. RESULTS In regard to coronary mortality, male and female rate ratios (highest vs lowest quintile) were 0.83 (95% confidence interval [CI] = 0.77, 0.91) and 0.95 (95% CI = 0.86, 1.05), respectively, for folate and 0.74 (95% CI = 0.65, 0.84) and 0.86 (95% CI = 0.73, 0.99), respectively, for B12. Intake of folate and B6 (but not B12) was significantly associated with cerebrovascular mortality. CONCLUSIONS B vitamins are associated with cardiovascular mortality in the general population.
Perinatal Outcome in Relation to Meconium Stained Amniotic Fluid

Aims and Objectives: To study maternal high risk factors associated with meconium stained amniotic fluid (MSAF). To compare the fetal outcome in relation to MSAF and clear amniotic fluid. To analyze the perinatal outcome in relation to MSAF. Methods: This prospective case control study was undertaken in 400 pa ents from November 2012 to October 2013. Results: Mean 1 minute and 5 minute Apgar scores were 6.77 ± 1.016 and 8.225 ± 0.94 in MSAF group and 7.095 ± 0.81 and 8.46 ± 0.73 in clear AF group. Maximum babies in MSAF group (50.5%) and clear AF group (33.5%) had NICU stay of 1-3 days. There was higher neonatal mortality in meconium stained liquor (2%) compared to clear liquor group (0.5%). Conclusion: Thick meconium is associated with increased fetal heart rate abnormalities, increased operative interventions, low Apgar scores, increased risk of birth asphyxia, meconium aspiration syndrome and over all increased perinatal mortality.
Fetal ECG extraction during labor using an adaptive maternal beat subtraction technique

Abstract Fetal ECG (FECG) monitoring using abdominal maternal signals is a non-invasive technique that allows early detection of changes in fetal wellbeing. Several other signal components have stronger energy than the FECG, the most important being maternal ECG (MECG) and, especially during labor, uterine EMG. This study proposes a new method to subtract MECG after detecting and removing abdominal signal segments with high-amplitude variations due to uterine contractions. The method removes MECG from abdominal signals using an approximation of the current MECG segment based on a linear combination of previous MECG segments aligned on the R-peak. The coefficients of the linear model are computed so that the squared error of the approximation over the whole current segment is minimized. Abdominal signal segments strongly affected by uterine contractions are detected by applying median filtering. The methods proposed are tested on real abdominal data recorded during labor, with FECG recorded using scalp electrodes synchronously recorded for comparison.
Systemic autoimmunity in BAFF‐R‐mutant A/WySnJ strain mice

Systemic lupus erythematosis is an autoimmune disease of unknown etiology. Lupus pathology is thought to reflect autoantibody‐mediated damage due to a failure of B lymphocyte tolerance. Since excessive B cell‐activating factor belonging to the TNF family (BAFF) expression correlates with human and murine lupus, and BAFF signals B cell survival through BAFF‐R, it is believed that excessive BAFF‐R signaling can subvert B cell tolerance and facilitate lupus development. Here we report the unexpected finding that BAFF‐R‐mutant A/WySnJ mice develop a lupus‐like syndrome. These mice carry the B cell maturation defect‐1 (Bcmd‐1) mutant allele of the Baffr gene. Bcmd‐1 causes premature B cell death and profound B cell deficiency. Despite having 90% fewer splenic B cells than normal mice, A/WySnJ mice had an 18‐fold increased frequency of splenocytes secreting IgM antibodies to dsDNA, and increased amounts of circulating IgM and IgG to dsDNA by 9 months of age. By age 11 months, most A/WySnJ mice displayed renal pathology characteristic of lupus, including proteinuria as well as periodic acid‐Schiff‐positive deposits and glomerular capillary bed destruction. Importantly, we genetically linked this autoimmunity to Bcmd‐1, since congenic AW.Baffr+/+ mice carrying a wild‐type allele developed none of these phenotypes. Our data provide the first evidence linking altered BAFF‐R signaling to the development of B cell‐mediated autoimmunity.
A study of perceptions of the adequacy of security

In the past several years, a number of researchers have raised the issue of the level of security concern among system users, suggesting that security may be undervalued in both centralized and decentralized IS departments, and among IS staff as well as end-users. Since protective measures often require significant managerial vigilance, an appropriate level of awareness and concern may be a prerequisite for adequate security protection. Given its importance, there is a need for a better understanding of what leads to security concern. This paper focuses on users’ perceptions about the security of their systems. Based on previous work on individuals’ attitudes and beliefs about IS and IS environments, it is hypothesized that a user’s concern about security is a function of three different constructs: industry risk, company actions, and individual awareness. The study tests the main assertions of the model, using a cross-sample comparison of perceptions from two different survey instruments. The first sample used 570 randomly selected DPMA members. The second sample surveyed 357 end-users. The theoretical model does provide some explanation for level of concern among IS professionals in the mainframe and minicomputer environment. Both company actions and individual awareness were statistically significant, although the explained variance was not large. Problems with using post hoc analysis may have contributed to the partial and weak support for the model.
Conceptual and Methodological Issues in Testing the Circumplex Structure of Data in Personality and Social Psychology

Circumplex representations of data have enjoyed widespread popularity in personality and social psychological research. In this article we review the conceptual assumptions implied by circumplex representations and we discuss the limitations of traditional statistical methods for testing these assumptions. A relatively nontechnical overview of a new covariance structure modeling approach to testing circumplex structure is provided. The use of this approach is illustrated with two published data sets. The advantages and disadvantages of this approach relative to more traditional statistical approaches are discussed. The conclusion is that the covariance structure modeling approach has significant advantages in that it provides a closer conceptual match to the theoretical assumptions of circumplex representations, supplies information more directly relevant to circumplex representations and permits more precise and flexible testing of hypotheses derived from circumplex representations.
Social, emotional, and behavioral functioning of children with juvenile rheumatoid arthritis.

OBJECTIVE To investigate the hypothesis that children with juvenile rheumatoid arthritis (JRA) would have more social and emotional problems than case-control classmates. METHODS Using a case-control design, children with JRA (n = 74), ages 8-14, were compared with case-control classmates (n = 74). Peer relationships, emotional well-being, and behavior, based on peer-, teacher-, parent-, and self-report scores on common measures, were compared using analysis of variance. RESULTS Relative to case-control classmates, children with JRA were similar on all measures of social functioning and behavior. Mothers reported more internalizing symptoms in the child with JRA, but child self reports and father reports showed no differences. Scores on all standardized measures were in the normal range for both the JRA and the case-control groups. CONCLUSION Children with JRA were remarkably similar to case-control children on measures of social functioning, emotional well-being, and behavior. These findings are not supportive of disability/stress models of chronic illness in childhood and suggest considerable psychological hardiness among children with JRA.
Genotyping of clinical and environmental multidrug resistant Enterococcus faecium strains

Context: Multidrug resistant (MDR) Enterococcus faecium is a nosocomial pathogen and clonal complex 17 (CC17) is the main genetic subpopulation of E. faecium in hospitals worldwide. Aims: There has thus far been no report of major E. faecium clones in Iranian hospitals. Subjects and Methods: The present study analyzed strains of MDR E. faecium obtained from patients and the Intensive Care Unit environments using pulsed field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) to determine the antibiotic resistance patterns and genetic features of the dominant. Results: clones of E. faecium. PFGE and MLST analysis revealed the presence of 17and 15 different subtypes, respectively. Of these, 18 (86%) isolates belonged toCC17. Most strains in this clonal complex harbored the esp gene and exhibited resistance to vancomycin, teicoplanin, ampicillin, ciprofloxacin, gentamicin, and erythromycin. The MLST results revealed 12 new sequence types (ST) for the first time. Approximately 50% of the STs were associated with ST203. Conclusion: Detection of E. faecium strains belonging to CC17 on medical equipment and in clinical specimens verified the circulation of high-risk MDR clones among the patients and in hospital environments in Iran.
From flies' eyes to our ears: Mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30

Normal vision in Drosophila requires NINAC, a class III myosin. Class III myosins are hybrid motor-signaling molecules, with an N-terminal kinase domain, highly conserved head and neck domains, and a class III-specific tail domain. In Drosophila rhabdomeres, NINAC interacts with actin filaments and with a PDZ scaffolding protein to organize the phototransduction machinery into a signaling complex. Recessive null mutations in Drosophila NINAC delay termination of the photoreceptor response and lead to progressive retinal degeneration. Here, we show that normal hearing in humans requires myosin IIIA, the human homolog of NINAC. In an extended Israeli family, nonsyndromic progressive hearing loss is caused by three different recessive, loss-of-function mutations in myosin IIIA. Of 18 affected relatives in Family N, 7 are homozygous and 11 are compound heterozygous for pairs of mutant alleles. Expression of mammalian myosin IIIA is highly restricted, with the strongest expression in retina and cochlea. The involvement of homologous class III myosins in both Drosophila vision and human hearing is an evolutionary link between these sensory systems.
Calculations on folding of segment B1 of streptococcal protein G.

We present an investigation of the folding thermodynamics and mechanism of segment B1 of streptococcal protein G. Molecular dynamics simulations of the fully solvated protein are used to probe thermodynamically significant states at different stages of folding. We performed several unfolding simulations to generate a database of initial conditions. The database is analyzed and clustered. The cluster centers extracted from this database were then used as starting points for umbrella sampling of the folding free energy landscape under folding conditions. The resulting sampling was combined with the weighted histogram analysis method. One and two-dimensional free energy surfaces were constructed along several order parameters and used to analyze the folding process. Our findings indicate that an initial collapse precedes the formation of significant native structure. Elements of local structure originate in the regions of the protein shown to have higher H/2H exchange protection factors in early stages of folding. A non-native contact, observed experimentally at the N terminus of the alpha-helix in a peptide excised from the protein, is seen to pre-organize the chain in early stages of folding. Collapse and early structure formation yields a compact globule with a significant number of water molecules present. Desolvation of the protein core is coincident with the final stages of folding from the compact state.
The effect of racial primes on the test performance of African-American and European-American children

Il existe maintenant des preuves solides que l’activation de stereotypes negatifs peut entraver les performances des adultes aux tests standardises. En revanche, on ne sait que peu de chose sur l’âge a partir duquel les enfants deviennent sensibles a ces effets. Dans la presente etude, nous avons examine l’impact d’une breve manipulation de la saillance de l’origine ethnique sur les performances d’enfants americains (7-9 ans) d’origine africaine ou europeenne. Les enfants devaient colorier une image representant soit deux enfants blancs, soit deux enfants noirs, soit deux chiens dans la condition controle, puis passaient une epreuve ecrite difficile de capacite verbale. Conformement a la possibilite que la performance au test des enfants puisse etre affectee de facon consistante avec les stereotypes par un amorcage subtil de la race, les enfants des deux origines ethniques ont obtenu de meilleurs resultats dans la condition d’amorcage de l’ethnie europeenne et des resultats plus mauvais dans la condition d’amorcage de l’ethnie africaine, comparativement a la condition controle. Les implications de ces resultats pour notre comprehension de l’activation des stereotypes durant l’enfance sont discutees.
DNA Base Composition of Rickettsiae

There is a small but distinct difference in DNA base composition between the typhus and spotted fever groups of rickettsiae. The molar percentages of guanine plus cytosine for Rickettsia prowazeki, R. typhi, and R. canada are approximately 30, for R. rickettsi, R. conori, and R. akari they are about 32.5. The percentage for trench fever rickettsia, Rochalimaea quintana, is 38.6.
İlköğretim İkinci Kademe Öğrencilerinde Duygusal Zeka ve Yaşam Doyumunun İncelenmesi

Bu arastirmanin amaci , ilkogretim ikinci kademe ogrencilerinin duygusal zeka duzeyleri ile yasam doyumu arasindaki iliskinin belirlenmesi ve farkli degiskenler acisindan incelenmesidir. Arastirmanin katilimcilarini Izmir ili metropol bolgedeki okullarda okuyan ve arastirmaya gonullu olarak katilmayi isteyen 151’i kiz (%51.54), 142’si erkek (%48.46) olmak uzere toplam 293 ogrenci olusturmaktadir. Yapilan istatistiksel analizler sonucunda yasam doyumu ve duygusal zeka alanlari arasindaki iliskilerin pozitif yonde anlamli bir iliski oldugu tespit edilmistir. Genel Duygusal Zeka ortalamalari cinsiyete gore incelendiginde kizlarin ortalamasinin erkeklerin ortalamasindan anlamli duzeyde yuksek oldugu saptanmistir. Genel Duygusal Zeka alaninda anne baba tutumuna gore anlamli farklilarin oldugu tespit edilmistir Genel Duygusal Zeka ortalamalarinda ve yasam doyumu ortalamalarinda anne- baba egitim duzeyine gore anlamli farklilik olmadigi tespit edilmistir
Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection

An earlier report has shown that herpes simplex virus 1 virions package RNA. Experiments designed to reveal the identity of the virion proteins capable of binding the RNA and to show whether the mRNA carried in the newly infected cells was expressed showed the following: (i) 32P-labeled riboprobe generated by in vitro transcription of the US8.5 ORF bound three proteins identified as the products of US11, UL47, and UL49 (VP22) genes. (ii) Viral RNA was bound to UL47 or US11 proteins immune precipitated from cells transduced with baculoviruses expressing UL47 or US11 and then superinfected with HSV-1 under conditions that blocked DNA synthesis and assembly of virions. (iii) Virions were purified from cells transduced with a baculovirus encoding a US8.5 protein fused to green fluorescent protein and superinfected with an HSV-1 mutant lacking the US8–12 genes. HEp-2 cells infected with these virions expressed the chimeric protein in ≈1% of infected cells. (iv) In mixed cultures, untreated Vero cells acquired the mRNA encoding the green fluorescent–US8.5 chimeric protein from HEp-2 cells doubly transduced with the genes encoding VP22 and the chimeric protein. The transfer was RNase sensitive and VP22 dependent, indicating that the RNA encoded by the chimeric gene was transferred to Vero cells as mRNA. We conclude that (i) three virion proteins are capable of binding RNA; (ii) the packaged RNA can be expressed in newly infected cells; and (iii) the UL47 protein was earlier reported to shuttle from nucleus to the cytoplasm and may transport RNA. VP22 thus appears to be a member of a new class of viral proteins whose major function is to bind and transport infected cell mRNA to uninfected cells to create the environment for effective initiation of infection.