Miracle-dz/UniFAR-FTUs huggingface dataset:
Sex Disparity in Blood Pressure Levels Among Nigerian Health Workers

Sex disparity in hypertension prevalence is well established in developed nations; however, there is paucity of data on the distribution of hypertension prevalence between the sexes in developing countries. Therefore, the authors examined sex differences in hypertension prevalence and cardiovascular risk factors in a sample of 352 healthy hospital workers in Nigeria. The mean ages of the men and women were 37.2±7.9 and 44.7±9.1 years, respectively. Thirty‐five percent of participants were hypertensive, with 54% on treatment and 70% with controlled blood pressure. Men had a higher prevalence of hypertension (38.4% vs 33.0%) and prehypertension (37.6% vs 29.7%). Women had significantly higher odds of developing hypertension and of being on treatment. Mean blood pressure and fasting plasma glucose values were higher in men, while women were more often older, obese, and dyslipidemic and had a lower mean estimated glomerular filtration rate (P<.0001). These findings indicate sex disparity in blood pressure among hospital employees. Sex‐focused management of hypertension is therefore advocated for hospital employees.
Anterior Mid-Tibial Stress Fractures. Results of Surgical Treatment

Background and Aims: An anterior mid-tibial stress fracture is an uncommon, but possibly career threatening condition for an athlete. We wanted to evaluate the results of the surgical treatment of this notorious stress fracture and compare two different surgical methods. Material and Methods: Forty-nine anterior mid-tibial stress fractures were treated surgically in 45 patients during the years 1985–2005. All the patients were athletes, mainly runners. The mean age of the patients was 26 years. Thirty-four of the fractures occurred in men and 15 in women. The first method of treatment (anteromedial and lateral drilling) was used in 20 operations and the second method (laminofixation) in 29 operations. Results: Good results were achieved with drilling in only 50% of the operations, where as with laminofixation good results were achieved in 93% of operations. This difference was statistically significant (p = .002). Healing of the stress fracture after laminofixation occurred in less than 6 months. The length of the plate used in the laminofixation had no effect on the end result. Conclusions: An anterior mid-tibial stress fracture may often lead to delayed union or non-union in vigorously training athletes. Surgical treatment with laminofixation proved to be superior to tibial fracture site drilling.
Examining the Determinants of Mobile Location-based Services' Continuance

The continuance of use is an important topic of IS research. However, in the past, many researchers have focused on adoption rather than IS continuance. Studying continuance is of equal importance, because if use does not persist, this may limit the revenues of the provider. This is particularly true for consumer-oriented services, which rely on advertising, or subscription-based revenue models. In this paper, we investigate the determinants of location-based services (LBS) continuance as a relevant case study for the examination of IS continuance generally. A research model is developed and empirically tested through a survey of a representative sample in Germany. The proposed model builds on and extends the Limayem et al. model of IS continuance. Our analysis highlights the importance of habit and emotion in LBS continuance. The results indicate that habit has a stronger predictive power than continuance intentions for LBS continuance and that emotions are an important driver for user satisfaction with LBS.
Characteristics and Outcomes of Treatment for Non-ST-Segment Elevation Acute Coronary Syndrome: Results from a Single Center Registry.

BACKGROUND Acute coronary syndrome (A CS) is a leading health burden worldwide. The Siriraj non-ST-segment elevation acute coronary syndrome (NST E-A CS) registry was established in 2012. Here, we report in-hospital outcomes and one-year outcomes from patients in the registry. OBJECTIVE To investigate and report characteristics and outcomes of treatment for NSTE-ACS at one year from a single center MATERIAL AND METHOD All patients admitted to Siriraj Hospital with diagnosis of NSTE-ACS were enrolled. Baseline demographic information, presenting signs and symptoms, electrocardiogram, and blood chemistry were recorded. In-hospital complications and outcomes of treatment were also collected and recorded. After being discharged from the hospital, patients were followed-up for one year. RESULTS Two-hundred patients were evaluated between January 2012 and August 2013. A majority of patients (65.5%) presented with angina. Median TIMI risk score was 4. Thirty-two percent of patients had GR ACE risk score greater than 140. In-hospital mortality was 3.5% (95% CI 2.0-7.0). The most common complication was heart failure (36.5%). Three patients had CVA during admission. At one year the mortality rate was 5% (95% CI 3.0-9.0). Unplanned readmission rate was 9.5%. CONCLUSION Most patients in the registry were high-risk ACS patients. In-hospital mortality and one-year mortality rates were 3.5% and 5%, respectively. Results from this study were comparable to results reported by previous studies from the Western world
Stratigraphic investigations of carbon isotope anomalies and Neoproterozoic ice ages in Death Valley, California

An unusual richness of biogeochemical events is recorded in Neoproterozoic‐ Cambrian strata of the Death Valley region, California, United States. Eight negative carbon isotope (d13C) excursions are found in carbonate units between 1.08 Ga and the Precambrian/Cambrian boundary; four of these excursions occur in carbonates that contain textural features similar to those found globally in postglacial ‘‘cap carbonates’’ (including one or more of the following: laminite with rollup structures, apparent ‘‘tube rocks,’’ seafloor precipitates, and sheet-crack cements). However, only two of these units, the Sourdough limestone member of the Kingston Peak Formation and the Noonday Dolomite, rest directly upon glacial strata. The basal Beck Spring Dolomite and the Rainstorm Member of the Johnnie Formation each contain negative excursions and cap-carbonate‐like lithofacies, but do not rest on known glacial deposits. If the negative d13C excursions are assumed to record depositional processes, two equally interesting hypotheses are possible: (1) The Death Valley succession records four glacial pulses in Neoproterozoic time, but glacial units are not preserved at two stratigraphic levels. (2) Alternatively, other global oceanographic processes can cause negative excursions and cap-carbonate‐ like facies in addition to, or independent of, glaciation.
A Sperm-Associated WD Repeat Protein Orthologous to Chlamydomonas PF20 Associates with Spag6, the Mammalian Orthologue of Chlamydomonas PF16

ABSTRACT cDNAs were cloned for the murine and human orthologues of Chlamydomonas PF20, a component of the alga axoneme central apparatus that is required for flagellar motility. The mammalian genes encode transcripts of 1.4 and 2.5 kb that are highly expressed in testis. The two transcripts appear to arise from alternative transcription start sites. The murine Pf20 gene was mapped to chromosome 1, syntenic with the location of the human gene on chromosome 2. An antibody generated against an N-terminal sequence of mouse Pf20 recognized a 71-kDa protein in sperm and testis extracts. Immunocytochemistry localized Pf20 to the tails of permeabilized sperm; electron microscope immunocytochemistry showed that Pf20 was located in the axoneme central apparatus. A murine Pf20-green fluorescent protein fusion protein expressed in Chinese hamster ovary cells accumulated in the cytoplasm. When coexpressed with Spag6, the mammalian orthologue of Chlamydomonas PF16, Pf20 was colocalized with Spag6 on polymerized microtubules. Yeast two-hybrid assays demonstrated interaction of the Pf20 WD repeats with Spag6. Pf20 was markedly reduced in sperm collected from mice lacking Spag6, which are infertile due to a motility defect. Our observations provide the first evidence for an association between mammalian orthologues of two Chlamydomonas proteins known to be critical for axoneme structure and function.
Disability Levels of College‐Aged Men With a History of Osgood‐Schlatter Disease

Osgood-Schlatter disease (OSD), which is a traction apophysitis of the tibial tuberosity, is one of the most common orthopedic conditions that adolescent athletes will encounter. Adolescent athletes with OSD typically present with pain, swelling, and tenderness over the tibial tuberosity that worsens with athletic activity. Few published reports have described the effects of OSD on the disability levels of athletes beyond adolescence. Therefore, the purpose of this study was to assess the disability levels of college-aged male subjects (n = 25, mean age = 20.3 years) who have a history of OSD and compare their status to a control group of healthy male subjects with no history of OSD (n = 25, mean age = 20.4 years) matched by intercollegiate sport and age. The mean time from being diagnosed with OSD to participation in this study was 7.6 ± 2.4 years for subjects in the OSD group. All subjects completed the Knee Outcome Survey Activities of Daily Living Scale and Sports Activity Scale, which served as our measure of disability. The results indicated that subjects with a history of OSD scored significantly lower than subjects in the control group on both the Knee Outcome Survey Activities of Daily Living Scale and Sports Activity Scale, indicating that subjects with OSD experienced higher levels of disability than subjects in the control group.
Simultaneous Inoculation of Malbec (Vitis vinifera) Musts with Yeast and Bacteria: Effects on Fermentation Performance, Sensory and Sanitary Attributes of Wines

Summary Malolactic fermentation has important consequences for the quality of wine. The present study analyzes the effect of timing of inoculation with bacteria on the performance of alcoholic and malolactic fermentation in Malbec musts from a warm climate wine growing region during two consecutive vintages, with a specific consideration for the sensory and sanitary wine parameters. In this study traditional vinification, where malolactic bacteria were inoculated after the completion of alcoholic fermentation, was compared with a simultaneous inoculation with yeast and bacteria. The experiment was made on pilot scale which closely reproduces winery conditions. The obtained results point out that simultaneous inoculation resulted in a reduction of total time of fermentation and a better control of the malolactic fermentation due to the early dominance of a selected bacterial strain. There were no negative effects on yeast population and alcoholic fermentation performance observed. Differences between the wine sensory attributes were no significant or they were in favour of simultaneous inoculations. No statistical differences in the biogenic amine levels between different timings of inoculation were found.
Prevalence of Mental Disorders and Addictions 2 among the Homeless Population in the Greater Paris 3 Area , France 4

The Samenta study was conducted in 2009 in the Greater Paris area to estimate the 12 prevalence of psychiatric disorders among the homeless. A cross-sectional survey was performed 13 with a three-stage random sample of homeless people (n = 859), including users of day services, 14 emergency shelters, hot meal distribution, long-term rehabilitation centres and social hotels. 15 Information was collected by a lay interviewer, using the Mini International Neuropsychiatric 16 Interview, and completed by a psychologist through an open clinical interview. In the end, a 17 psychiatrist assessed the psychiatric diagnosis according to the ICD10. One third of the homeless in 18 the Paris area had at least one severe psychiatric disorder: psychotic disorders (13%), anxiety 19 disorders (12%) or severe mood disorders (7%). One in five was alcohol dependent and 18% were 20 drug users. Homeless women had significantly higher prevalence of anxiety disorders and 21 depression and men were more likely to suffer from psychotic disorders. Homeless people of 22 French origin were at higher risk of SPD, as well as people who experienced various adverse life 23 events before the age of 18 (running away, sexual violence, parental disputes, and/or addictions) 24 and those who experienced homelessness for the first time before the age of 26. The prevalence 25 rates of main psychiatric disorders within the homeless population of our study are consistent with 26 those reported in other Western cities. Our results advocate for an improvement in detection, 27 housing and care of psychiatric homeless. 28
Question Answering in Webclopedia

SHAPE ADJECTIVE COLOR DISEASE TEXT NARRATIVE* GENERAL-INFO DEFINITION USE EXPRESSION-ORIGIN HISTORY WHY-FAMOUS BIO ANTECEDENT INFLUENCE CONSEQUENT CAUSE-EFFECT METHOD-MEANS CIRCUMSTANCE-MEANS REASON EVALUATION PRO-CON CONTRAST RATING COUNSEL-ADVICE To create the QA Typology, we analyzed 17,384 questions and their answers (downloaded from answers.com); see (Gerber, 2001). The Typology contains 94 nodes, of which 47 are leaf nodes; a section of it appears in Figure 2. Each Typology node has been annotated with examples and typical patterns of expression of both Question and Answer, as indicated in Figure 3 for Proper-Person. Question examples Question templates Who was Johnny Mathis' high school track coach? who be 's Who was Lincoln's Secretary of State? Who was President of Turkmenistan in 1994? who be of Who is the composer of Eugene Onegin? Who is the CEO of General Electric? Actual answers Answer templates Lou Vasquez, track coach of.and Johnny Mathis , of Signed Saparmurad Turkmenbachy [Niyazov], of president of Turkmenistan . Turkmenistan’s President Saparmurad Niyazov. ’s . in Tchaikovsky's Eugene Onegin. 's Mr. Jack Welch, GE chairman. Chairman John Welch said . GE's | of related role-verb Figure 3. Portion of QA Typology node annotations for Proper-Person.
‘The waiting game’: are current chlamydia and gonorrhoea near-patient/point-of-care tests acceptable to service users and will they impact on treatment?

The objective of this study was to assess the length of time service users were prepared to wait for chlamydia and gonorrhoea (CT/GC) near-patient/point-of-care test (NP-POCT) results and to determine the possible effect on management. Individuals attending two UK clinics from November 2013 to February 2014 were surveyed asking the maximum length of time they would wait for CT/GC NP-POCT results after consultation. Linked CT/GC prevalence and treatment rates were analysed. A total of 1817 participants were surveyed, and 1356 provided CT/GC NAAT samples, in which it was found that 115 (8.5%) could wait over 90 minutes in clinic for their result. 115 received treatment at consultation, of which 50 were CT/GC negative and 12 were treated for urethritis or cervicitis; 38 attended as CT/GC contacts. Six of this population would have waited over 90 minutes were NP-POCTs available. A total of 129 tested CT/GC positive, of whom 65 were treated at their consultation, 61 at a later date, and three were untreated. Twelve of these 129 patients would also have waited over 90 minutes for a NP-POCT result. We conclude that 90-minute NP-POCTs are not acceptable to most clinic attendees and would not have impacted on treatment rates or inappropriate prescribing, and 20-minute NP-POCTs show a marginal benefit in treating CT/GC. While NP-POCTs for CT/GC are promising, they must meet client expectations and enhance disease management in order to be accepted by patients and clinicians.
Fat body of the frog Rana esculenta: An ultrastructural study

In the frog, the fat body is the largest body lipid deposit and is associated with the gonad. The aim of the present work was to investigate the fine structure of the fat body at different periods of the annual cycle and during prolonged starvation. Results indicate that fat body cells of Rana esculenta caught in autumn and after winter hibernation resemble mammalian adipocytes of white adipose tissue and contain markers of adipose tissue, such as S‐100 protein and lipoproteinlipase. However, unlike mammalian adipocytes, fat body adipocytes consistently show small lipid droplets associated with their single, large lipid deposits, a lack of a definite external lamina, and the presence of cellular prolongations and spicula at their surfaces. Transmission and scanning electron microscopy in association with lanthanum tracer experiments suggest that in fat body adipocytes a vesicular‐tubular system connects the cytoplasm and the interstitial space. In June (i.e., during the reproductive period), fat body adipocytes appear to have lost much of their lipid deposit and adjacent adipocytes show interdigitation of their plasma membranes and prominent Golgi complexes. In starved frogs, fat body cells can be almost devoid of lipid and in regression to a near‐mesenchymal state. Nevertheless, these fat bodies still contain lipoproteinlipase activity (≈ 45% of that found in lipid‐filled ones), indicating persistent adipose differentiation of the cells therein. Results presented here show that the R. esculenta fat body is an adipose organ undergoing reversible extreme changes in adipocyte fat content, which are associated with definite ultrastructural features. The fat body represents a suitable model for studying adipose tissue under different and extreme physiological conditions. © 1996 Wiley‐Liss, Inc.
Characterization and stability of extracellular alkaline proteases from halophilic and alkaliphilic bacteria isolated from saline habitat of coastal Gujarat, India

The present study deals with the isolation and characterization of the moderately halophilic-alkaliphilic bacteria from a saline habitat in western India. Eight different bacterial strains were isolated using enrichment techniques at 20% (w/v) NaCl and pH 10. The isolates exhibited diversity towards gram's reaction, colony and cell morphology. They were able to grow and produce alkaline protease over a broad range of NaCl, 5-20% (w/v) and pH, 8-10. None of the isolates could grow at pH 7, and one could not grow even at pH 8. Crude and partially purified proteases from strain S5 were subjected to characterization with reference to pH, salt stability and protein folding. Optimum protease activity and stability was recorded at 10% salt and pH 9-9.5. Denaturation kinetics of S5 alkaline protease along with a reference protease was studied at 8M urea followed by renaturation. The S5 alkaline protease could be partially renatured up to 32% of the original activity. Despite of the fact that all the 8 isolates were from the same site, they displayed significant diversity with respect to their salt requirement for growth and enzyme secretion. While the effect of pH was less demarcated on growth, the protease production was significantly affected. Isolate S5 produced substantial amount of halotolerant and alkaline protease. The activity and stability of the alkaline protease in a broader range of pH and salt would definitely make this enzyme an important candidate for various industrial applications.
Peroxide generation by p 47 phox-Src activation of Nox 2 has a key role in protein kinase C-induced arterial smooth muscle contraction

Gupte SA, Kaminski PM, George S, Kouznestova L, Olson SC, Mathew R, Hintze TH, Wolin MS. Peroxide generation by p47-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction. Am J Physiol Heart Circ Physiol 296: H1048 –H1057, 2009. First published January 23, 2009; doi:10.1152/ajpheart.00491. 2008. —Protein kinase C (PKC) stimulation of NAD(P)H oxidases (Nox) is an important component of multiple vascular disease processes; however, the relationship between oxidase activation and the regulation of vascular smooth muscle contraction by PKC remains poorly understood. Therefore, we examined the signaling cascade of PKC-elicited Nox activation and the role of superoxide and hydrogen peroxide in mediating PKCinduced vascular contraction. Endothelium-denuded bovine coronary arteries showed a PKC-dependent basal production of lucigenin (5 M)-detected Nox oxidase-derived superoxide, which was stimulated fourfold by PKC activation with 10 M phorbol 12,13-dibutyrate (PDBu). PDBu appeared to increase superoxide generation by Nox2 through both p47 and peroxide-dependent Src activation mechanisms based on the actions of inhibitors, properties of Src phosphorylation, and the loss of responses in aorta from mice deficient in Nox2 and p47. The actions of inhibitors of contractile regulating mechanisms, scavengers of superoxide and peroxide, and responses in knockout mouse aortas suggest that a major component of the contraction elicited by PDBu appeared to be mediated through peroxide derived from Nox2 activation stimulating force generation through Rho kinase and calmodulin kinase-II mechanisms. Superoxide generated by PDBu also attenuated relaxation to nitroglycerin. Peroxidederived from Nox2 activation by PKC appeared to be a major contributor to the thromboxane A2 receptor agonist U46619 (100 nM)-elicited contraction of coronary arteries. Thus a p47 and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of PKC.
Coupled rotational dynamics of Saturn's thermosphere and magnetosphere: a thermospheric modelling study

We use a numerical model of Saturn's thermosphere to investigate the flow of angular momentum from the atmosphere to the magnetosphere. The thermosphere model is driven by Joule heating and ion drag calculated from a simple model of the magnetospheric plasma flows and a fixed model of the ionospheric conductivity. We describe an initial study in which our plasma flow model is fixed and find that this leads to several inconsistencies in our results. We thus describe an improved model in which the plasma flows are allowed to vary in response to the structure of the thermospheric winds. Using this improved model we are able to analyse in detail the mechanism by which angular momentum extracted from the thermosphere by the magnetosphere is replaced by transport from the lower atmosphere. Previously, this transport was believed to be dominated by vertical transport due to eddy viscosity. Our results suggest that transport within the upper atmosphere by meridional winds is a much more important mechanism. As a consequence of this, we find that the rotational structures of the thermosphere and magnetosphere are related in a more complex way than the eddy viscosity model implies. Rather than the thermosphere behaving as a passive component of the system, the thermosphere-magnetosphere interaction is shown to be a two-way process in which rotational structures develop mutually. As an example of this, we are able to show that thermospheric dynamics offer an explanation of the small degree of super-corotation that has been observed in the inner magnetosphere. These results call into question the usefulness of the effective Pedersen conductivity as a parameterisation of the neutral atmosphere. We suggest that a two-parameter model employing the true Pedersen conductivity and the true thermospheric rotation velocity may be a more accurate representation of the thermospheric behaviour.