Miracle-dz/UniFAR-FTUs huggingface dataset:
Developmental gender differences in children in a virtual spatial memory task.

OBJECTIVE Behavioral achievements are the product of brain maturation. During postnatal development, the medial temporal lobe completes its maturation, and children acquire new memory abilities. In recent years, virtual reality-based tasks have been introduced in the neuropsychology field to assess different cognitive functions. In this work, desktop virtual reality tasks are combined with classic psychometric tests to assess spatial abilities in 4- to 10-year-old children. METHOD Fifty boys and 50 girls 4-10-years of age participated in this study. Spatial reference memory and spatial working memory were assessed using a desktop virtual reality-based task. Other classic psychometric tests were also included in this work (e.g., the Corsi Block Tapping Test, digit tests, 10/36 Spatial Recall Test). RESULTS In general terms, 4- and 5-year-old groups showed poorer performance than the older groups. However, 5-year-old children showed basic spatial navigation abilities with little difficulty. In addition, boys outperformed girls from the 6-8-year-old groups. Gender differences only emerged in the reference-memory version of the spatial task, whereas both sexes displayed similar performances in the working-memory version. CONCLUSION There was general improvement in the performance of different tasks in children older than 5 years. However, results also suggest that brain regions involved in allocentric memory are functional even at the age of 5. In addition, the brain structures underlying reference memory mature later in girls than those required for the working memory.
Modifiable Impairments Predict Progressive Disability Among Older Persons

Our purpose was to determine the extent to which a predetermined set of modifiable impairments predicted progression of disability. Method: We conducted a 3-year follow-up of two community-based cohorts of older adults. The impairment areas included lower extremity, upper extremity, hearing, vision, and affect. Home management and social or productive activities were the domains of function investigated. Results: All five impairments were of at least borderline significance in predicting decline in both functional domains in both cohorts with the exception of hearing for home management activities. The five impairments together explained from 17% to 23% of the decline seen in the functional outcomes (partial R 2s 0.17 to 0.23). Discussion: Five prevalent and potentially modifiable impairments explained much of the progressive disability experienced. Given the priority that older patients place on function as a health outcome, these impairments should be routinely assessed and modified.
Breast Fat Grafting with Platelet-Rich Plasma: A Comparative Clinical Study and Current State of the Art

Background: The role of platelet-rich plasma in enhancing fat graft take is attracting the scientific community. There is, however, a lack of clinical studies on the matter. The aim of this article is to report the authors' experience in breast fat grafting with and without platelet-rich plasma and to investigate the state of the art on adipose tissue platelet-rich plasma enrichment. Methods: The authors retrospectively reviewed 42 women who underwent breast fat grafting between September of 2007 and September of 2009. Seventeen of these patients (40 percent) were grafted with fat (according to Coleman) enriched with platelet-rich plasma at 10 percent (group A), and 25 patients (60 percent) received only fat grafts according to Coleman (group B). All patients underwent preoperative breast ultrasound and mammography and were regularly followed up with breast ultrasound 3 months later and then at 6-month intervals. The reconstructive and aesthetic outcomes were evaluated using the following parameters: (1) clinical outcomes according to the surgeons and the patient, (2) the rate of liponecrosis at breast ultrasound, and (3) the need of further fat grafting to achieve the planned result. Results: The clinical outcomes, the rate of liponecrosis at breast ultrasound, and the need for further fat grafting reveal that fat grafting plus platelet-rich plasma at 10 percent is not superior to Coleman fat grafting alone. Conclusions: In the authors' retrospective analysis, no effect of platelet-rich plasma was seen in enhancing fat graft take when compared with the Coleman fat graft. Further research and prospective clinical studies are needed to understand the role of platelet-rich plasma, if any, in fat grafting.
High-Quality Draft Genome Sequence of the Xanthomonas translucens pv. cerealis Pathotype Strain CFBP 2541

ABSTRACT Xanthomonas translucens pv. cerealis is the causal agent of bacterial leaf streak on true grasses. The genome of the pathotype strain CFBP 2541 was sequenced in order to decipher mechanisms that provoke disease and to elucidate the role of transcription activator-like (TAL) type III effectors in pathogenicity.
Association of Erectile Dysfunction and Hypogonadism with Metabolic Syndrome in Men with Lower Urinary Tract Symptoms of Younger and Older Age Groups

The aim of this study was to evaluate the incidence and severity of erectile dysfunction (ED) and hypogonadism in 193 men presenting with lower urinary tract symptoms (LUTSs) in the younger (20 - 39 years old) and older (40 - 60 years old) age groups depending on the presence of metabolic syndrome (MetS). Triglycerides, glucose and high-density lipoprotein cholesterol, serum total testosterone (TT), sex hormone-binding globulin, prostate-specific antigen, pituitary hormones levels were measured in serum. Standardized criteria (2009) were used to determine the prevalence of MetS. Patients were assessed based on the International Prostate Symptom Score (IPSS) and the IPSS-Quality of Life (IPSS-QoL) for LUTSs and the International Index of Erectile Function (IIEF) for ED. Hypogonadism was determined in accordance with the ISA, ISSAM, EAU, EAA and ASA recommendations. In men with MetS in the younger age group the incidence of ED was 2.4 times higher, and that of low TT level and hypogonadism was 8.4 times higher compared to men without the syndrome. In the older age group, an increased incidence of ED and low TT level in men with MetS compared to men without the syndrome was on the trend level, but the incidence of hypogonadism was for sure higher (by 1.6 times). In conclusion, the study showed that ED and hypogonadism are associated with MetS by a high degree of certainty in young men with LUTSs. In men of the older age group with LUTSs, the presence of MetS is not so clearly associated with ED and hypogonadism due to the fact that the incidence of these urogenital diseases is also high in men without MetS.
Eosinophil Major Basic Protein-1 Does Not Contribute to Allergen-Induced Airway Pathologies in Mouse Models of Asthma1

The relationship between eosinophils and the development of Ag-induced pulmonary pathologies, including airway hyper-responsiveness, was investigated using mice deficient for the secondary granule component, major basic protein-1 (mMBP-1). The loss of mMBP-1 had no effect on OVA-induced airway histopathologies or inflammatory cell recruitment. Lung function measurements of knockout mice demonstrated a generalized hyporeactivity to methacholine-induced airflow changes (relative to wild type); however, this baseline phenotype was observable only with methacholine; no relative airflow changes were observed in response to another nonspecific stimulus (serotonin). Moreover, OVA sensitization/aerosol challenge of wild-type and mMBP-1−/− mice resulted in identical dose-response changes to either methacholine or serotonin. Thus, the airway hyper-responsiveness in murine models of asthma occurs in the absence of mMBP-1.
Why Are the Climatological Zonal Winds Easterly in the EquatorialUpper Troposphere

Abstract Using 16 years of NCEP–NCAR reanalysis data on the 200-mb surface, it is shown that in the deep Tropics, the horizontal transient eddy momentum flux accelerates the zonal mean zonal wind. This acceleration is mainly due to transient eddies of intraannual and interannual timescales, and to those associated with the Madden–Julian oscillation (MJO). The interannual timescale eddy fluxes are dominated by eastward-propagating disturbances with zonal wavenumber 2 and a period of 2–4 yr, suggesting that these eddy fluxes may be tied to the El Nino–Southern Oscillation. In the deep Tropics, the single most important factor that decelerates the zonal mean zonal wind is the horizontal momentum flux divergence due to the transient meridional circulation associated with seasonal cycle of the Hadley cells. The deceleration by the transient meridional circulation is much greater than the acceleration due to the transient eddies. This result indicates that a nonzero obliquity of the earth is crucial for maintai.
Role of DNA Methylation Profile in Diagnosing Astroblastoma: A Case Report and Literature Review

Astroblastoma is a rare tumor of the central nervous system (CNS) with uncertain clinical behavior. Recently, DNA methylation profiling has been shown to provide a highly robust and reproducible approach for the classification of all CNS tumors across different age groups. By using DNA methylation profiling, a subset of CNS high-grade tumors with astroblastoma-like morphology characterized by the meningioma 1 gene (MN1) rearrangements, has been identified; they were termed “CNS high-grade neuroepithelial tumors with MN1 alteration” (CNS-HGNET-MN1). Here, we describe a case of CNS-HGNET-MN1 diagnosed by DNA methylation profiling, using Illumina Infinium HumanMethylationEPIC BeadChip (EPIC), that offers the opportunity to conduct a brief literature review. The patient presented with an episode of partial seizures involving the right hemisoma. A gross total resection was performed. No other treatment was proposed in light of the histological and molecular findings. After 21 months, the patient is disease-free in good clinical conditions. Also in view of this case, we recommend DNA-methylation profiling as an important tool for diagnosis and more effective patient stratification and management.
Biomarkers for breast cancer: The search continues

Commentary to: Reevaluating Cathepsin D as a biomarker for breast cancer: Serum activity levels versus histopathology Daniel E Abbott, Naira V Margaryan, Jacqueline Jeruss, Seema Khan, Virginia Kaklamani, David J Winchester, Nora Hansen, Alfred Rademaker, Zhila Khalkhali-Ellis and Mary J.C. Hendrix
Three uses of the Herbrand-Gentzen theorem in relating model theory and proof theory

One task of metamathematics is to relate suggestive but nonelementary modeltheoretic concepts to more elementary proof-theoretic concepts, thereby opening up modeltheoretic problems to proof-theoretic methods of attack. Herbrand's Theorem (see [8] or also [9], vol. 2) or Gentzen's Extended Hauptsatz (see [5] or also [10]) was first used along these lines by Beth [1]. Using a modified version he showed that for all first-order systems a certain modeltheoretic notion of definability coincides with a certain proof theoretic notion. In the present paper the Herbrand-Gentzen Theorem will be applied to generalize Beth's results from primitive predicate symbols to arbitrary formulas and terms. This may be interpreted as showing that (apart from some relatively minor exceptions which will be made apparent below) the expressive power of each first-order system is rounded out, or the system is functionally complete, in the following sense: Any functional relationship which obtains between concepts that are expressible in the system is itself expressible and provable in the system. A second application is concerned with the hierarchy of second-order formulas. A certain relationship is shown to hold between first-order formulas and those second-order formulas which are of the form (∃T1)…(∃Tk)A or (T1)…(Tk)A with A being a first-order formula. Modeltheoretically this can be regarded as a relationship between the class AC and the class PC⊿ of sets of models, investigated by Tarski in [12] and [13].
Relationships Between Career Indecision, Search for Work Self-Efficacy, and Psychological Well-Being in Italian Never-Employed Young Adults

Although different studies have investigated career choices as cognitive acts of decision-making, non-cognitive components also play an important role. The study tries to develop an empirically based model of career decision-making process linking cognitive (search for work self-efficacy - SWSE) and non-cognitive (psychological well-being - PWB) components. In particular, the study investigates, among 148 never-employed Italian young adults, to what extent the relationship between SWSE and career indecision in terms of lack of readiness (LoR) can be explained by their common relationship with PWB. Results highlighted that SWSE is negatively associated with LoR when considered in absence of PWB. However, when PWB was included in one comprehensive model, it was positively associated with SWSE and negatively related to LoR. Moreover, the presence of PWB nullified the negative association between SWSE and LoR, meaning that PWB shares a large extent of variance with these variables. Implications are discussed in the light of theoretical expectations and limitations.
Editorial: A New Classification of Adult Autoimmune Myositis

Since Bohan and Peter first described their original classification and diagnostic criteria for polymyositis (PM) and dermatomyositis (DM) in 1975 (1), rheumatologists have witnessed remarkable progress in the understanding of the heterogeneous nature of these diseases. Notwithstanding major advances made in other aspects of PM and DM such as skeletal muscle histopathology (2,3), progress has been afforded notably by the discovery of serum autoantibodies associated with myositis, which were unknown at the time that the Bohan and Peter criteria were first described (4,5). We focus herein on advances in the nosology of PM and DM brought forward by these autoantibodies and attempt to integrate emerging concepts into a new classification. We also focus on some implications for trial design and outcome measures that stem from this novel classification. Clinicoserologic analysis of the associations of newly identified autoantibodies has allowed separation of classic PM and DM into newly recognized disease subgroups with distinct phenotypes, i.e., distinct clinical features, course, prognosis, association with cancer, and even therapeutic responses. In addition to the discovery of these autoantibodies, immunogenetic as well as pathophysiologic studies (6) have provided strong evidence of an autoimmune pathogenesis in most PM and DM subgroups, warranting their classification under the more specific terminology of “autoimmune myositis” (AIM) in replacement of “idiopathic inflammatory myopathies. ” As shown in Table 1, 5 major syndromes/disease entities are now classified under the AIM banner: overlap myositis (OM) (7), pure (classic) DM, necrotizing autoimmune myositis (NAM) (8), PM, and possibly, sporadic inclusion body myositis. In this article, we focus on adult OM, DM, and NAM, which account for . 90% of adult AIM patients seen by rheumatologists in an academic setting.
Differential expression of factor XIIIa and CD34 in cutaneous mesenchymal tumors

The histogenetic relationship amongst various dendritic cells of the dermis which may express markers including factor XIIIa (FXIIIa) or CD34 remains unclear. In this study we utilized a sensitive indirect immunoperoxidase staining technique to identify CD34 and FXIIIa, as well the monocyte/macrophage markers KP‐1 and MAC 387 expression in a variety of cutaneous dermal tumors of mesenchymal origin to see if differentia] expression of CD34 vs FXIIIa exists. Tumors studied included dermatofibroma (DF) (N = 10), keloid (N=9), atypical fibroxanthoma (AFX) (N = 3), and dermatofibrosarcoma protuberans (DFSP) (N = 7). DF were all composed of FXIIIa + spindle‐shaped and stellate tumor cells (mean score = 4.9 or ≥ 75% FXIIIa +) as previously reported, but these cells rarely (< 10%) expressed CD34. Six of 7 DFSP were found to be > 75% CD34+ and FXIIIa negative, while one DFSP was negative for both CD34 and FXIIIa. In all DFSP, there were trapped FXIIIa+ cells which were distinct from the spindle‐shaped tumor cells. AFX showed sparse populations of FXIIIa + cells in the stroma (mean score = 1.33 or 10–25% positive), which were distinct from the atypical giant cells characteristic of these tumors. Keloid similarly contained trapped FXIIIa+ cells (mean score = 0.44 or < 5% positive) that were distinct from the spindle‐shaped fibroblasts of the tumor mass. Dendritic and spindle‐shaped cells within these tumors were consistently both KP‐1 and Mac‐387 negative, while all lesions studied were characterized by scattered round, histiocytic cells which were KP‐1 + and/or Mac‐387 + irrespective of tumor cell type. We suggest that these tumors can be delineated by their relative degrees of FXIIIa and CD34 expression and that these neoplasms may be a useful link with which to study the relationship between CD34+ cells and dermal dendrocytes.
Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes

In the present study, we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of Zucker diabetic fatty rats and Zucker lean control rats. To induce hypothyroidism, Zucker lean control and Zucker diabetic fatty rats at 7 weeks of age orally received the vehicle or methimazole, an anti-thyroid drug, treatment for 5 weeks and were sacrificed at 12 weeks of age in all groups for blood chemistry and immunohistochemical staining. In the methimazole-treated Zucker lean control and Zucker diabetic fatty rats, the serum circulating thyronine (T3) and thyroxine (T4) levels were significantly decreased compared to levels observed in the vehicle-treated Zucker lean control or Zucker diabetic fatty rats. This reduction was more prominent in the methimazole-treated Zucker diabetic fatty group. Glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium-binding adapter molecule 1 (Iba-1)-immunoreactive microglia in the Zucker lean control and Zucker diabetic fatty group were diffusely detected in the hippocampal CA1 region and dentate gyrus. There were no significant differences in the glial fibrillary acidic protein and Iba-1 immunoreactivity in the CA1 region and dentate gyrus between Zucker lean control and Zucker diabetic fatty groups. However, in the methimazole-treated Zucker lean control and Zucker diabetic fatty groups, the processes of glial fibrillary acidic protein tive astrocytes and Iba-1 immunoreactive microglia, were significantly decreased in both the CA1 region and dentate gyrus compared to that in the vehicle-treated Zucker lean control and Zucker diabetic fatty groups. These results suggest that diabetes has no effect on the morphology of astrocytes and microglia and that hypothyroidism during the onset of diabetes prominently reduces the processes of astrocytes and microglia.
Erythromelalgic Thrombotic Thrombocythemia (ETT) and Hemorrhagic Trombocythemia (HT) in Patients with Essential Thrombocythaemia (ET) and Polycythaemia Vera (PV)

We analysed between 1908 and 1985 of two hundred cases of thrombocythemia from the literature between 1908 and 1985. Erythromelalgic, acrocyanotic ischemia and digital gangrene, cerebral or coronary ischemic events (erythromelalgic thrombotic thrombocyhemia: ETT) in 99 thrombocythemia patients (essential thrombocythemia: ET N=67 and polycythemia vera: PV N=32) occured at platelet counts in excess of 400 × 10 9 /L. Hemorrhagic complications at time of presentation of hemorrhagic thrombocythemia (HT) in 100 HT patients included melana and/or hematemesis, skin bleedings (bruises, subcutaneous hematomas, painfull hematomas after trauma, ecchymoses, but not petechiae, epistaxis and gum bleeding and secondary bleeding after trauma or surgery. ETT occurred at an early stage of thrombocythemia with a mean platelet count of 1110+477 × 10 9 /L, whereas HT occurred at significantly higher platelet counts in excess of 1000 × 10 9 /L with a mean platelet count of 2016+1070 × 10 9 /L. HT patients frequently had a previous history of ETT or paradoxical occurrences of both thrombosis and bleeding (ETT/PHT). The degree of thrombocythosis determined the sequential occurrence of ETT, HT in ET and PV patients. Hypersensitive thrombocythemic platelets (sticky platelets) are involved in the etiology of platelet-mediated thrombosis at platelet counts above 400 × 10 9 /L whereas bleedings at high platelet count is related to an acquired von Willebrand syndrome processes on top of a blood clot retraction disturbance with erythrocyte fall out, that causes painful subcutaneous hematomas with a central swelling (clot) after a blow, trauma and secondary bleeding after surgery in thrombocythemia patients.
Happy in the Hood? The Impact of Residential Segregation on Self‐Reported Happiness

Previous research consistently finds that racially-based residential segregation is associated with poor economic, health, and social outcomes. The purpose of this paper is to explore the relationship between residential segregation and self-reported happiness. Using panel data from the National Survey of Families and Households (NSFH), we begin by estimating ordinary least squares (OLS) regressions of happiness on a measure of MSA-level segregation, controlling for a rich set of individual, neighborhood, and state characteristics. The OLS results suggest that increased segregation is associated with a reduction in happiness among blacks. To deal more appropriately with the potential endogeneity of location choice, we extend the methodology to fully exploit the panel structure of the NSFH and incorporate individual fixed effects into the happiness equation. Contrary to the OLS results, our fixed effects estimates imply that blacks are happier in more segregated metropolitan areas. The paper discusses the implications of these results within the context of current integration policies.
Voluntary adoption of IFRS: A study of determinants for UK unlisted firms

We examine the determinants of voluntary adoption of IFRS by medium-to-large UK unlisted firms (8417 firms comprising 287 IFRS firms and 8130 non-IFRS firms in 2009). Analysing voluntary adoption allows us to better understand the cost/benefits of choosing a specific set of accounting standards. Using univariate and multivariate analyses, we find that internationality, leverage, firm size and auditor reputation help explain UK unlisted firms' choice of voluntarily selecting IFRS. Other firm characteristics such as profitability, capital intensity, industry, growth, ownership structure, and employee productivity do not appear to play a significant role in the decision. Additionally, we find that newly incorporated firms a higher probability of adopting IFRS.
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

A number of recent reports indicate that massive overdoses of acetaminophen can produce a fulminant hepatic necrosis in man. Acetaminophen-induced hepatic necrosis thereforne was examised in experimental animals. Centrilobular hepatic necrosis similar to that seen in man was shown to be dose dependent in mice and rats. To determine whether acetaminophen-induced hepatotoxicity was mediated throug an active metabolite, acetaminophen concentrations in rat and mouse tissues were compared with the severity of liver damage after alteration of the rate of metabolism of acetaminophen. Phenobarbital pretreatment stimulated the disappearance of acetaminophen from tissues but markedly potentiated the hepatic necrosis. In contrast, piperonyl butoxide pretreatment inhibited the metabolism and disappearance of acetaminophen from tissues yet dramatically protected against hepatic necrosis. Additional studies demonstrated that pretreatment with 3-methylcholanthrene also potentiated acetaminophen-induced hepatic necrosis whereas cobaltous chloride, which inhibits synthesis of cytochrome P-450, prevented the hepatic damage. We propose that acetaminophen-induced hepatic necrosis is mediated by a toxic metabolite of acetaminophen.