Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies

Objectives Models based on the multistage theory of cancer predict that rates of malignant mesothelioma continuously increase with time since first exposure (TSFE) to asbestos, even after the end of external exposure. However, recent epidemiological studies suggest that mesothelioma rates level off many years after first exposure to asbestos. A gradual clearance of asbestos from the lungs has been suggested as a possible explanation for this phenomenon. We analysed long-term trends of pleural and peritoneal cancer mortality in subjects exposed to asbestos to evaluate whether such trends were consistent with the clearance hypothesis. Methods We used data from a pool of 43 Italian asbestos cohorts (51 801 subjects). The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalised to include a term representing elimination of fibres over time. Results Rates of pleural cancer increased until 40 years of TSFE, but remained stable thereafter. On the other hand, we observed a monotonic increase of peritoneal cancer with TSFE. The model taking into account asbestos clearance fitted the data better than the traditional one for pleural (p=0.004) but not for peritoneal (p=0.09) cancer. Conclusions Rates of pleural cancer do not increase indefinitely after the exposure to asbestos, but eventually reach a plateau. This trend is well described by a model accounting for a gradual elimination of the asbestos fibres. These results are relevant for the prediction of future rates of mesothelioma and in asbestos litigations.
Plasma next generation sequencing and droplet digital PCR‐based detection of epidermal growth factor receptor (EGFR) mutations in patients with advanced lung cancer treated with subsequent‐line osimertinib

Gene mutation analysis from plasma circulating tumor DNA (ctDNA) can provide timely information regarding the mechanism of resistance that could translate to personalised treatment. We compared concordance rate of next generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR) in the detection of the EGFR activating and T790M mutation from plasma ctDNA with diagnostic tissue biopsy‐based assays. The second objective was to test whether putative osimertinib resistance associated mutations were detectable from plasma using NGS.
Plasma natriuretic peptide levels reflect the status of the heart failure in fetuses with arrhythmia

Abstract Objectives To evaluate the significance of natriuretic peptide (NP) levels in fetal arrhythmia. Study design Cardiovascular profile (CVP) scores and umbilical vein (UV) NP levels at birth were compared by different fetal arrhythmia statuses. Results Fetal tachyarrhythmia (n = 22), bradyarrhythmia (n = 12), extrasystole (n = 12) and controls (n = 127) were enrolled in this study. Fetal antiarrhythmic therapy was performed in fetuses with tachyarrhythmia (n = 18) and bradyarrhythmia (n = 5). Fetal arrhythmias were divided into three groups: group A (arrhythmia controlled at birth, n = 17), Group B (arrhythmia uncontrolled at birth, n = 9) and Group C (fetal therapy not indicated, n = 20). Group B had significantly lower CVP scores and higher NP levels than the other two groups and controls (p < .01). Groups A and C had significantly lower CVP scores than controls, but NP levels in Groups A and C showed no differences compared with controls. Conclusions UV NP concentrations reflect the severity of fetal arrhythmia and responses to fetal therapy.
miR-29b Reverses T helper 1 cells/T helper 2 cells Imbalance and Alleviates Airway Eosinophils Recruitment in OVA-Induced Murine Asthma by Targeting Inducible Co-Stimulator

Asthma is a complex chronic disease and the pathogenesis is still not entirely clear. In this study, we aimed to clarify the role and mechanism of miR-29b in the development of asthma. We observed that miR-29b levels were decreased in the lung and spleen of OVA-induced asthmatic mice. Reverse transcription-quantitative polymerase chain reaction and flow cytometry demonstrated that the inducible co-stimulator (ICOS) expression at mRNA and protein levels was elevated in the lung of asthmatic mice, and miR-29b expression in the lung of asthmatic mice was negatively associated with ICOS mRNA levels by Pearson Correlation analysis. Additional, flow cytometry showed that the percentage of CD4+ICOS+ T cells in the lung and spleen was regulated by miR-29b, and dual luciferase reporter assay confirmed ICOS was a target gene of miR-29b. Furthermore, miR-29b overexpression in asthmatic mice was induced with miR-29b agomir by intranasal administration; miR-29b alleviated total inflammatory cell infiltration and CCL24 levels, decreased IL-5 levels in bronchoalveolar lavage fluid and serum, and upregulated IFN-γ expression in serum. This study demonstrates that miR-29b targets ICOS, thereby reverses the imbalance of T helper 1 cells (Th1)/Th2 responses and decreases eosinophils recruitment in the airway, which are key features of allergic airway inflammation. Therefore, miR-29b might be an attractive candidate target for asthma treatment.
Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi

Trypanosoma brucei (T.b.) rhodesiense is the cause of the acute form of human African trypanosomiasis (HAT) in eastern and southern African countries. There is some evidence that there is diversity in the disease progression of T.b. rhodesiense in different countries. HAT in Malawi is associated with a chronic haemo-lymphatic stage infection compared to other countries, such as Uganda, where the disease is acute with more marked neurological impairment. This has raised the question of the role of host genetic factors in infection outcomes. A candidate gene association study was conducted in the northern region of Malawi. This was a case-control study involving 202 subjects, 70 cases and 132 controls. All individuals were from one area; born in the area and had been exposed to the risk of infection since birth. Ninety-six markers were genotyped from 17 genes: IL10, IL8, IL4, HLA-G, TNFA, IL6, IFNG, MIF, APOL, HLA-A, IL1B, IL4R, IL12B, IL12R, HP, HPR, and CFH. There was a strong significant association with APOL1 G2 allele (p = 0.0000105, OR = 0.14, CI95 = [0.05–0.41], BONF = 0.00068) indicating that carriers of the G2 allele were protected against T.b. rhodesiense HAT. SNP rs2069845 in IL6 had raw p < 0.05, but did not remain significant after Bonferroni correction. There were no associations found with the other 15 candidate genes. Our finding confirms results from other studies that the G2 variant of APOL1 is associated with protection against T.b. rhodesiense HAT.
Landing maneuvers of houseflies on vertical and inverted surfaces

Landing maneuvers of flies are complex behaviors which can be conceptually decomposed into sequences of modular actions, including body-deceleration, leg-extension, and body rotations. These behavioral ‘modules’ must be coordinated to ensure well-controlled landing. The composite nature of these behaviors induces kinematic variability, making it difficult to identify the central rules that govern landing. Many previous studies have relied on tethered preparations to study landing behaviors, but tethering induces experimental artefacts by forcing some behaviors to operate in open-feedback control loop while others remain closed-loop. On the other hand, it is harder for the experimenter to control the stimuli experienced by freely-flying insects. One approach towards understanding general mechanisms of landing is to determine the common elements of their kinematics on surfaces of different orientations. We conducted a series of experiments in which the houseflies, Musca domestica, were lured to land on vertical (wall landings) or inverted (ceiling landings) substrates, while their flight was recorded with multiple high-speed cameras. We observed that, in both cases, well-controlled landings occurred when the distance at which flies initiated deceleration was proportional to flight velocity component in the direction of substrate. The ratio of substrate distance and velocity at onset of deceleration (tau) was conserved, despite substantial differences in mechanics of vertical vs. ceiling landings. When these conditions were not satisfied, their landing performance was compromised, causing their heads to collide into the substrate. Unlike body-deceleration, leg-extension in flies was independent of substrate distance or approach velocity. Thus, the robust reflexive visual initiation of deceleration is independent of substrate orientation, and combines with a more variable initiation of leg-extension which depends on surface orientation. Together, these combinations of behaviors enable flies to land in a versatile manner on substrates of various orientations.
Effect of Smoking and Locations of Dental Implants on Peri-Implant Parameters: 3-Year Follow-Up

Background Smoking may be a risk factor for marginal bone loss (MBL) and oral mucosal inflammation surrounding dental implants. This retrospective study evaluated the effects of smoking on dental implants in patients with fixed implant-supported prostheses over a period of 36 months following loading. Material/Methods We assessed 120 patients (68 women, 52 men, ages 19–74 years (mean age: 55.10 years) with 315 implants. Implants were classified according to location in the upper and lower jaws and anterior (placed between canines) or posterior (placed between pre-molars and molars) as follows: 1=maxilla anterior, 2=maxilla posterior, 3=mandible anterior, 4=mandible posterior. We also measured MBL, plaque index (PI), sulcus bleeding index (SBI), and probing depth (PD). P-values less than 0.05 were considered statistically significant. Results MBL was statistically greater in smokers (P<0.001) as compared to non-smokers in both jaws. MBL did not vary significantly by location in either group (smokers: p=0.415; non-smokers: p=0.175). Mean PI and PD scores were significantly higher in smokers as compared to non-smokers (P<0.001). A positive correlation was found between PI and PD scores in both groups. No statistically significant difference in SBI was observed between the 2 groups (P>0.05). Conclusions Smoking was associated with increases in marginal bone loss around implants, independent of their location in the jaws. Also, both plaque indices and probing depths were greater in smokers than in non-smokers.
Identification of Key Genes and Pathways in Pancreatic Cancer Gene Expression Profile by Integrative Analysis

Background: Pancreatic cancer is one of the malignant tumors that threaten human health. Methods: The gene expression profiles of GSE15471, GSE19650, GSE32676 and GSE71989 were downloaded from the gene expression omnibus database including pancreatic cancer and normal samples. The differentially expressed genes between the two types of samples were identified with the Limma package using R language. The gene ontology functional and pathway enrichment analyses of differentially-expressed genes were performed by the DAVID software followed by the construction of a protein–protein interaction network. Hub gene identification was performed by the plug-in cytoHubba in cytoscape software, and the reliability and survival analysis of hub genes was carried out in The Cancer Genome Atlas gene expression data. Results: The 138 differentially expressed genes were significantly enriched in biological processes including cell migration, cell adhesion and several pathways, mainly associated with extracellular matrix-receptor interaction and focal adhesion pathway in pancreatic cancer. The top hub genes, namely thrombospondin 1, DNA topoisomerase II alpha, syndecan 1, maternal embryonic leucine zipper kinase and proto-oncogene receptor tyrosine kinase Met were identified from the protein–protein interaction network. The expression levels of hub genes were consistent with data obtained in The Cancer Genome Atlas. DNA topoisomerase II alpha, syndecan 1, maternal embryonic leucine zipper kinase and proto-oncogene receptor tyrosine kinase Met were significantly linked with poor survival in pancreatic adenocarcinoma. Conclusions: These hub genes may be used as potential targets for pancreatic cancer diagnosis and treatment.
Thermal behavior alleviates thermal discomfort during steady-state exercise without affecting whole-body heat loss.

We tested the hypothesis that thermal behavior resulting in reductions in mean skin temperature alleviates thermal discomfort and mitigates the rise in core temperature during light intensity exercise. In a 27 ±0°C, 48 ±6% relative humidity environment, 12 healthy subjects (6 females) completed 60 min of recumbent cycling. In both trials, subjects wore a water perfused suit top continually perfusing 34 ± 0ºC water. In the behavior trial, the upper body was maintained thermally comfortable by pressing a button to perfuse cool water (2.2 ±0.5ºC) through thetop for 2 min per button press. Metabolic heat production (Control: 404 ±52 W; Behavior: 397 ±65 W, P=0.44) was similar between trials. Mean skin temperature was reduced in the behavior trial (by -2.1 ±1.8ºC, P<0.01) due to voluntary reductions in water perfused top temperature (P<0.01). Whole body (P=0.02) and local sweat rates were lower in the behavior trial (P≤0.05). Absolute core temperature was similar (P≥0.30), however the change in core temperature was greater in the behavior trial after 40 min of exercise (P≤0.03). Partitional calorimetry did not reveal any differences in cumulative heat storage (Control: 554 ±229; Behavior: 544 ±283 kJ, P=0.90). Thermal behavior alleviated whole body thermal discomfort during exercise (by -1.17 ±0.40 a.u., P<0.01). Despite lower evaporative cooling in the Behavior trial, similar heat loss was achieved by voluntarily employing convective cooling. Therefore, thermal behavior resulting in large reductions in skin temperature is effective at alleviating thermal discomfort during exercise without affecting whole body heat loss.
Power of averaging: Noise reduction by ensemble coding of multiple faces.

Face perception is an important ability in social interaction. Holistic processing of a face enables us to understand facial attributes easily despite similarity of faces. Ensemble coding of multiple faces enables us to judge the characteristics of a crowd easily despite the limited capacity of the visual system. The current study investigated whether holistic processing of a face is different from ensemble coding of multiple faces and, if so, how. We tested how face inversion influenced both holistic processing and ensemble coding. Participants were asked to discriminate emotion intensities of either a single face or a crowd of faces (angry or happy face[s]). More important, face(s) or facial features were sometimes presented upside-down. We found that a face inversion effect was larger in discriminating individual emotion than in discriminating emotion in a crowd. As the number of inverted components increased, both discrimination abilities were more disrupted. The degree of disruption varied depending on different emotions and features in holistic processing, but it did not vary in ensemble coding. The inversion effect was weaker in ensemble coding than in holistic processing because noise produced by inversion might have cancelled out in averaging. Different inversion effects depending on different emotions and facial features were observed only in holistic processing because uneven contributions of facial features to individual emotion processing might have reduced the effectiveness of noise cancellation. Together, these results suggest that ensemble coding provides a powerful mechanism of noise cancellation involved with individual representation. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Evaluation of cytotoxicity and genotoxicity induced by oleic acid‐coated iron oxide nanoparticles in human astrocytes

Iron oxide nanoparticles (ION) are gaining importance as diagnostic and therapeutic tool of central nervous system diseases. Although oleic acid‐coated ION (O‐ION) have been described as stable and biocompatible, their potential neurotoxicity was scarcely evaluated in human nervous cells so far. The primary aim of this work was to assess the molecular and cellular effects of O‐ION on human astrocytes (A172 cells) under different experimental conditions. An extensive set of cyto‐ and genotoxicity tests was carried out, including lactate dehydrogenase release assay, cell cycle alterations, and cell death production, as well as comet assay, γH2AX assay, and micronucleus (MN) test, considering also iron ion release capacity and alterations in DNA repair ability. Results showed a moderate cytotoxicity related to cell cycle arrest and cell death promotion, regardless of serum presence. O‐ION induced genotoxic effects, namely primary DNA damage, as detected by the comet assay and H2AX phosphorylation, but A172 cells were able to repair this particular damage because no chromosome alterations were found (confirmed by MN test results). Accordingly, no effects on the DNA repair ability were observed. The presence of serum proteins did not influence O‐ION toxicity. Iron ions released from the O‐ION surface seemed not to be responsible for the cytotoxic and genotoxic effects observed. Environ. Mol. Mutagen. 2019. © 2019 Wiley Periodicals, Inc.
Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis

Whether Saccharomyces boulardii (S boulardii) as an adjuvant therapy are beneficial to H pylori eradication remains controversial. The aim of the study was to update and determine the effects of S boulardii as an adjuvant therapy on H pylori eradication rates and adverse effects.
Thinking mindfully: How mindfulness relates to rumination and reflection in daily life.

Mindfulness is a state of awareness comprising an attentional focus on the present moment and a nonjudgmental stance. It is associated with affective well-being and assumed to facilitate adaptive emotion regulation. To support this claim at the within-person level, we investigated associations between 2 mindfulness facets (present-moment attention and nonjudgmental acceptance), 2 emotion-regulation strategies varying in adaptiveness (rumination and reflection), and positive and negative affect in everyday life using data from 2 experience-sampling (ESM) studies. Study 1 consisted of N = 70 students who completed 54 prompts on average. Study 2 consisted of N = 179 middle-aged adults who completed 69 prompts on average. Results from both studies were highly consistent: The mindfulness facet nonjudgmental acceptance was more strongly related to less concurrent rumination, whereas the mindfulness facet present-moment attention was related to more concurrent reflection. As predicted, both mindfulness facets interacted with rumination in the prediction of changes in affect. When individuals were in a more mindful state, rumination was less strongly associated with increases in negative affect, and was less strongly associated with decreases in positive affect. However, mindfulness interacted with reflection in the prediction of changes in affect in an unexpected way: At higher levels of nonjudgmental acceptance, reflection was no longer associated with changes in affect. Together, these results suggest that emotion regulation strategies can be more or less adaptive depending on the level of mindfulness. They also accord with the proposal that mindfulness inhibits maladaptive emotion regulation and its impact on affective well-being. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Chronic disease prevention and management programs in primary care: Realist synthesis of 6 programs in Quebec.

OBJECTIVE To identify the mechanisms associated with success and failure of chronic disease prevention and management (CDPM) programs, as well as their key contexts. DESIGN Realist synthesis. SETTING Six primary care CDPM programs funded between 2011 and 2013 in Quebec. PARTICIPANTS Patients, health providers, program leaders, and other stakeholders involved in CDPM programs. METHODS A collaborative research process was implemented, involving representatives from the executive and advisory committees: researchers, health care providers, decision makers, and patients and families. Leaders were asked to provide all documents related to their programs to the research team. The documents were selected depending on their relevance and rigour. The thematic analysis of each program consisted of identifying the outcomes and mechanisms, as well as the specific contexts associated with these outcomes. Results for each program were validated by its leader before synthesizing the results of all programs together. MAIN FINDINGS A total of 108 documents (eg, grant applications, scientific reports) were collected from the programs. Positive and negative outcomes were observed at the patient, health care provider, and health care system levels. Four main mechanism categories were associated with outcomes: patient-centred interdisciplinary care; self-management support and a motivational approach; professional support; and care coordination and relationships with partners. The main contextual factors that influenced the successes of these mechanisms were related to patients (multimorbidity, involvement of family caregivers), to health care providers (professional training, culture of interprofessional collaboration, mobilization of family physician), and to health care organizations (coordination between services, history of collaboration between partners, funding). CONCLUSION This study confirms the essential role of patient-centred interdisciplinary care; self-management support and a motivational approach; professional support; and care coordination and relationships with partners when caring for patients with chronic diseases. It constitutes a relevant contribution for stakeholders involved in primary care transformation and should be used to inform the sustainability and scaling up of CDPM programs.
Tell it like it is: When politically incorrect language promotes authenticity.

When a person's language appears to be political-such as being politically correct or incorrect-it can influence fundamental impressions of him or her. Political correctness is "using language or behavior to seem sensitive to others' feelings, especially those others who seem socially disadvantaged. " One pilot study, 6 experiments, and 3 supplemental experiments (N = 4,956) demonstrate that being politically incorrect makes communicators appear more authentic-specifically, less susceptible to external influence-albeit also less warm. These effects, however, are moderated by perceivers' political ideology and how sympathetic perceivers feel toward the target group being labeled politically correctly. In Experiments 1, 2, and 3 using politically incorrect language (e.g., calling undocumented immigrants illegals) made a communicator appear particularly authentic among conservative perceivers but particularly cold among liberal perceivers. However, in Experiment 4 these effects reversed when conservatives felt sympathetic toward the group that was being labeled politically correctly or incorrectly (e.g., calling poor Whites white trash). Experiment 5 tests why political incorrectness can boost authenticity, demonstrating that it makes communicators seem less strategic. Finally, Experiment 6 examines the use of political language in a meaningful field context: perceived persuasion in real political debates. Debaters instructed to be politically correct (vs. politically incorrect) were judged by their uninstructed conversation partners to be easier to persuade during the conversation, although they actually reported being similarly persuaded. Together, these findings demonstrate when and how using politically incorrect language can enhance a person's authenticity. (PsycINFO Database Record (c) 2019 APA, all rights reserved).