Miracle-dz/UniFAR-FTUs huggingface dataset:
Rectal perforation: An unusual complication of uterine artery embolisation

A 43-year-old nulliparous patient presented to the gynaecology outpatient department with a history of menorrhagia. Ultrasound scan confirmed large multiple fibroids with the largest being a subserosal posterior wall fibroid measuring greater than 10 cm. Bilateral hydronephrosis and deviation of the bladder to the left was also noted. She was counselled regarding treatment options and hysterectomy was advised; however, she was very reluctant to undertake this and was keen to proceed with UAE, although this was not recommended first line due to the size/position of the fibroids. A magnetic resonance imaging (MRI) scan was performed and confirmed a large multi-fibroid uterus with the largest fibroid noted to be posterior and subserosal measuring 140 mm 110 mm 150 mm (Figure 1). An uneventful UAE was performed, however she readmitted on day 4 with abdominal pain, diarrhoea and pyrexia. Inflammatory markers were raised and renal function had worsened. MRI was unremarkable and the presumed diagnosis was PES, as well as a concurrent urinary tract infection. Hence, the patient was treated conservatively with fluids and antibiotics. Symptoms were variable, but a further deterioration resulted in a readmission on day 39 with worsening pains and fever. This was again thought to be secondary to PES and managed conservatively. Gonadotropin-releasing hormone (GnRH) analogues were also administered to encourage fibroid shrinkage. She was readmitted on day 61 feeling generally unwell with worsening diarrhoea. Inflammatory markers continued to be raised and a repeat MRI scan confirmed a necrotic 160 mm 140 mm fibroid and at this stage, a hysterectomy was discussed in view of her ongoing worsening symptoms. Conservative management was pursued for a further 3 weeks, however a further deterioration and inpatient admission resulted in the decision to perform an abdominal hysterectomy. Operative findings were of widespread inflammatory bowel adhesions to the surface of the degenerating posterior wall subserous fibroid, which was noted to have a foul smell. At the base of the fibroid, a 1 cm defect was noted in the rectum. The rectal defect was repaired and a reversible colostomy was performed. Post-operatively, she made a rapid recovery and was discharged with a plan to reverse the colostomy in three months.
Clinical Profile of Patients with Rare Inherited Coagulation Disorders: A Retrospective Analysis of 67 Patients from Northern India

Introduction Inherited bleeding disorders are characterized by the absence or reduced level of clotting factors, and the clinical manifestations vary according to the type and magnitude of the deficient factor. Aim To study the clinical presentation of the rare inherited coagulation factor disorders in a tertiary care hospital and to compare the data from those reported in other populations. Methods Sixty-seven patients, who presented to the Department of Hematology, All India Institute of Medical Sciences, New Delhi, were evaluated retrospectively from 2005 to 2011. The tests performed included platelet count, prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), factors assay and clot solubility test in 5 M urea. Factor XI assays were aPTT based while factors V, VII and X assays were PT based. Results Male to female ratio was 2:1. The median age of onset of the first episode of bleeding was at 6 months (range, from birth to 20 years) whereas the median age of presentation to our hospital was 9 years (range, 2 months to 54 years). The most common deficient factor was factor X (43%), followed by factor XIII (27%) and factor VII (10%). Conclusion There is a wide gap between the initial manifestation of the bleeding disorders and first presentation to the tertiary care hospital for assessment and treatment. Factor X deficiency is the most common among these rare coagulation disorders in our population, whereas factor VII deficiency is more common in Iranian and North American population.
A Role for the Circadian Clock Protein Per1 in the Regulation of the NaCl Co-transporter (NCC) and the with-no-lysine Kinase (WNK) Cascade in Mouse Distal Convoluted Tubule Cells*

Background: The role of the circadian protein Per1 in the regulation of sodium reabsorption in the distal convoluted tubule (DCT) is unknown. Results: Per1 transcriptionally regulates the sodium transporter NCC and the WNK kinase cascade. Conclusion: Per1 regulates sodium reabsorption in the DCT through NCC and the WNK cascade. Significance: These data demonstrate a role for Per1 in the regulation of renal sodium transporters. It has been well established that blood pressure and renal function undergo circadian fluctuations. We have demonstrated that the circadian protein Per1 regulates multiple genes involved in sodium transport in the collecting duct of the kidney. However, the role of Per1 in other parts of the nephron has not been investigated. The distal convoluted tubule (DCT) plays a critical role in renal sodium reabsorption. Sodium is reabsorbed in this segment through the actions of the NaCl co-transporter (NCC), which is regulated by the with-no-lysine kinases (WNKs). The goal of this study was to test if Per1 regulates sodium transport in the DCT through modulation of NCC and the WNK kinases, WNK1 and WNK4. Pharmacological blockade of nuclear Per1 entry resulted in decreased mRNA expression of NCC and WNK1 but increased expression of WNK4 in the renal cortex of mice. These findings were confirmed by using Per1 siRNA and pharmacological blockade of Per1 nuclear entry in mDCT15 cells, a model of the mouse distal convoluted tubule. Transcriptional regulation was demonstrated by changes in short lived heterogeneous nuclear RNA. Chromatin immunoprecipitation experiments demonstrated interaction of Per1 and CLOCK with the promoters of NCC, WNK1, and WNK4. This interaction was modulated by blockade of Per1 nuclear entry. Importantly, NCC protein expression and NCC activity, as measured by thiazide-sensitive, chloride-dependent 22Na uptake, were decreased upon pharmacological inhibition of Per1 nuclear entry. Taken together, these data demonstrate a role for Per1 in the transcriptional regulation of NCC, WNK1, and WNK4.
Patellofemoral Arthroplasty

Abstract Patellofemoral arthroplasty can be an effective intermediate treatment for the patient with isolated arthritis of the anterior compartment of the knee. In the absence of patellar malalignment, results are optimized when an implant with sound geometric features is used, the prosthesis is appropriately aligned, and the soft tissues are balanced. Although previous prosthesis designs resulted in a relatively high prevalence of failure because of patellofemoral maltracking, patellofemoral catching, and anterior knee pain, newer prosthesis designs show promise in reducing the prevalence of patellofemoral dysfunction. Progressive tibiofemoral cartilage degeneration is another so‐called failure mechanism; such progressive degeneration underscores the importance of restricting the procedure to patients who do not have tibiofemoral chondromalacia. Because long‐term failure as a result of tibiofemoral degeneration may occur in approximately 25% of patients, patellofemoral arthroplasty may be considered an intermediate procedure for select patients with patellofemoral arthritis.
Elotuzumab: The First Monoclonal Antibody for the Treatment of Multiple Myeloma

© 2016 Harborside Press® Multiple myeloma (MM) is a hematologic cancer in which malignant plasma cells are formed. Plasma cells are mainly found in bone marrow and function within the body to attack and destroy antigens. Multiple myeloma occurs when malignant plasma cells accumulate in the bone marrow, leading to marrow failure and destruction of the bone. As the second most commonly diagnosed hematologic malignancy in the United States, 30,330 new cases of MM are estimated in 2016 (American Cancer Society, 2016). Although approximately 45% of patients survive 5 years after diagnosis, the disease remains incurable (Ashjian & Redic, 2015). In the past decade, there have been a number of recent therapeutic advances to address the current limitations. Initial treatment of MM varies depending on age, stage at diagnosis, and patient-specific factors such as comorbid conditions and cytogenetics. Current National Comprehensive Cancer Network (NCCN) guidelines for newly diagnosed MM involve two or more drugs in combination (NCCN, 2016). Although there are many treatment options available, multiple myeloma has a very high relapsing and refractory nature, and thus there is a need for further research and development of novel drugs in this setting. With the advent of innovative treatments with different mechanisms of action targeting specific proteins, agents such as elotuzumab (Empliciti) create an option for these relapsed patients.
Child Abuse and Domestic Violence in Families of Children Seen for Suspected Sexual Abuse

We surveyed families of children seen in a sexual abuse evaluation clinic regarding domestic violence in the child's home and physical and sexual abuse during childhood among the mothers. Domestic violence occurred in 54% (216/402) of the children's homes; 28% (111/392) of mothers reported childhood physical abuse, and 42% (167/395) reported sexual abuse. There were no differences in the rates of domestic violence (X2=0.42, 2df, p=0.8), maternal physical abuse (X2=2.40, 2df, p=0.3), or maternal sexual abuse (X2=2.11, 2df, p=0.3) based on whether our current patient was at high, medium, or low risk for having actually experienced sexual abuse. Neither domestic violence in the child's home nor the mother's childhood experience of abuse was increased if the child's perpetrator was a relative or lived in the home. Domestic violence in the child's home was more frequent if the mother had experienced physical abuse during childhood (65%, 70/107) than if she had not (48%, 130/271; X2=8.69, p<0.01). Child sexual abuse is part of a global pattern of victimization, and clinicians must address other forms of family violence when evaluating a child for allegations of sexual abuse.
Neurocognitive impairment as a moderator in the development of borderline personality disorder

Borderline personality disorder (BPD) is characterized by a pervasive instability of interpersonal relationships, affects, self-image, marked impulsivity, dissociation, and paranoia. The cognitive dimension of the disorder has received relatively little attention and is poorly understood. This paper proposes that neurocognitive impairment is a key moderator in the development of BPD and elaborates a possible pathway for the expression of the cognitive domain. Neurocognitive impairment is hypothesized to moderate the relationship between caretaking and insecure disorganized attachment and pathological dissociation in the formation of the disorder contributing to impaired metacognition and a range of cognitive difficulties. The empirical evidence from studies of cognitive processes, brain function, attachment, and dissociation that support this theory are reviewed and discussed. Areas for future research that might verify or refute this theory are suggested.The author thanks Geralyn Windt for assistance in manuscript preparation, Dr. Jack Maser for early review of the manuscript, and Dr. Elizabeth Twamley for her invaluable consultation and expert review of the manuscript.
Role of Interferon Regulatory Factor-1 in the Induction of Biliary Glycoprotein (Cell CAM-1) by Interferon-γ*

Biliary glycoprotein (BGP), also known as C-CAM-1, has been shown to be down-regulated in colon and prostate tumors. Previously, we demonstrated that BGP mRNA is up-regulated by interferon-γ (IFN-γ) in colon cancer cell lines (Takahashi, H., Okai, Y., Paxton, R. J., Hefta, L. J. F., and Shively, J. E. (1993) Cancer Res. 53, 1612-1619). We now show that the BGP promoter contains an interferon-sensitive response element (ISRE) that is specifically protected in in vivo footprints. Interferon regulatory factor-1 (IRF-1) was identified as the ISRE-binding factor by electrophoretic mobility shift assays. The induction of IRF-1 mRNA by IFN-γ in HT-29 cells reaches a maximum at 6 h and is superinduced by cycloheximide. Four mRNA species for BGP are induced by IFN-γ, the major band of which is inhibited by cycloheximide. Transfection of HT-29 cells with an IRF-1 expression plasmid (pAct-1) transactivates a BGP promoter reporter gene containing wild-type (but not mutant) ISRE. Electrophoretic mobility shift assay analysis of a second footprint reveals the binding of Sp1, an Sp1-like protein, and upstream stimulatory factor. The Sp1-like complex was also induced by IFN-γ treatment of HT-29 cells and may be a second point of transcriptional control for the BGP gene.
Microwave dielectric properties of binary solvent wateralcohol, alcohol-alcohol mixtures at temperatures between -35°C and +35°C and dielectric relaxation studies

In this work, our objective was to study the complex permittivity of binary mixtures of water-ethanol, water-methanol and methanol-ethanol with various mole fractions at temperature between -35 and 35 °C. Measurements were made in the frequency domain from 300 kHz to 1.3 GHz by means of an open ended coaxial line technique coupled to a network analyzer. Water-ethanol and water-methanol mixtures display a Kraszewski Law while methanol-ethanol mixture shows a Shivola-Kong Law. The static dielectric constant, es were obtained from the plateau of e'(ω) curve, in water rich mixture or alcohol rich mixture has similar real permittivity e' of pure liquids. The values of es mixtures increase by decreasing the temperature assigned to the cooperative dynamics H-bond system in mediums. The validity of permittivity measurements according to the temperature are verified by the Queen-King Law and the j (0 j2) A constants are compared with literature data. The dielectric relaxation behaviour of water-ethanol mixture can be better described with a Cole-Davidson function while for methanol-ethanol one, a Debye function gives a good fit. At 25 °C, the relaxation time  in the aqueous mixtures of ethanol and methanol sharply increased with increasing alcohol concentration.
Distribution and Isoform Characterization of Type XII Collagen in Bovine Cornea

Streptavidin peroxidase immunohistochemistry and immunoelectron microscopy were used to determine the localization of type XII collagen in sections from bovine corneas. Type XII collagen extracted from bovine cornea and skin was assayed by Western blotting. Immunohistochemical experiments showed that type XII collagen was restricted to the corneal stroma; it was not present in corneal epithelium, epithelial basement membrane, Descemet’s membrane or endothelium. Type XII collagen was distributed throughout the corneal stroma, and it was prominently localized at the superficial stroma. Immunoelectron-microscopic examination demonstrated that type XII collagen was regularly found along the surface of banded collagen fibrils with a periodic distribution. By Western blot analysis, we observed that extracts from bovine cornea contained both the long and short isoforms of type XII collagen, whereas extracts from bovine skin contained only the short isoform. The homogeneous distribution and/or presence of the long isoform of type XII collagen may be related to the characteristically regular arrangement of collagen fibrils and thereby the transparency of corneal tissue.
Unique tomographic reconstruction of vector fields using boundary data

The problem of reconstructing a vector field v(r) from its line integrals (through some domain D) is generally undetermined since v(r) is defined by two component functions. When v(r) is decomposed into its irrotational and solenoidal components, it is shown that the solenoidal part is uniquely determined by the line integrals of v(r). This is demonstrated in a particularly simple manner in the Fourier domain using a vector analog of the well-known projection slice theorem. In addition, under the constraint that v (r) is divergenceless in D, a formula for the scalar potential phi(r) is given in terms of the normal component of v(r) on the boundary D. An important application of vector tomography, i.e., a fluid velocity field from reciprocal acoustic travel time measurements or Doppler backscattering measurements, is considered.
Estudo do ensaio SPT-T e sua aplicação na prática de engenharia de fundações

Esta pesquisa tem por objetivo analisar, detalhadamente, o ensaio SPT-T, procurando fornecer ao meio tecnico subsidios para a sua adequada utilizacao. Para tanto, foram desenvolvidas as seguintes principais atividades: levantamento de dados de sondagens SPT-T junto as empresas executoras, totalizando sete mil pares de resultados (N;T); construcao de um torquimetro eletrico com sistema de aquisicao automatica de dados, proporcionando a obtencao da curva torque versus ângulo-de-rotacao; realizacao de ensaios SPT-T em seis Campos Experimentais, nos quais ja se dispunha informacoes geotecnicas do subsolo e dados de provas-de-carga em fundacoes. Tambem, na Baixada Santista, foram executados um furo de sondagem SPT-T e outro de ensaio de palheta. Atraves dos resultados dos ensaios e das curvas torque versus ângulo-de-rotacao foram realizadas as seguintes analises: − Definir torques maximo e residual, bem como diferenciar a forma da curva em funcao do tipo de solo ; − Fazer uma proposta inicial de previsao da capacidade-de-carga de estacas atraves da adesao solo-amostrador, fT, proposta por Ranzini (1988); − Estudar a utilizacao dos parâmetros obtidos atraves do Cone de Penetracao Estatica, CPT, com os parâmetros obtidos atraves do SPT-T; − Mostrar a variabilidade das relacoes Tmax/N e Tmax/Tres e − Sugerir um procedimento para a execucao do ensaio SPT-T. Abstract
Nonlinear heat equation for nonhomogeneous anisotropic materials: A dual‐reciprocity boundary element solution

A dual‐reciprocity boundary element method is presented for the numerical solution of initial‐boundary value problems governed by a nonlinear partial differential equation for heat conduction in nonhomogeneous anisotropic materials. To assess the validity and accuracy of the method, some specific problems are solved. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2010
An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice.

OBJECTIVE Inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are characterized by chronic relapsing inflammation. The transcription of many of the proteins which mediate the pathogenesis in inflammatory bowel disease (e.g., TNFalpha, ICAM-1, VCAM-1) is NF-kappaB-dependent. IkappaB kinase is critical in transducing the signal-inducible activation of NF-kappaB and, therefore, represents a potentially promising target for the development of novel agents to treat inflammatory bowel disease and other inflammatory diseases. RESULTS Here we show that BMS-345541, a highly selective inhibitor of IkappaB kinase, inhibited the TNFalpha-induced expression of both ICAM-1 and VCAM-1 in human umbilical vein endothelial cells at the same concentration range as cytokine expression is inhibited in monocytic cells (IC(50) congruent with 5 microM). Against dextran sulfate sodium-induced colitis in mice, BMS-345541 administered orally at doses of 30 and 100 mg/kg was effective in blocking both clinical and histological endpoints of inflammation and injury. CONCLUSION This represents the first example of an inhibitor of IkappaB kinase with anti-inflammatory activity in vivo and indicates that inhibitors of IkB kinase show the promise of being highly efficacious in inflammatory disorders such as inflammatory bowel disease.
Using Java and Linda for Parallel Processing in Bioinformatics for Simplicity , Power and Portability

This paper discusses the use of Java and the Linda coordination language (specifically, IBM’s TSpaces implementation) for the construction of parallel processing applications in the field of bioinformatics. Much existing work in this field makes use of scripting languages such as Perl. Java provides a more powerful programming and deployment environment with strong support for processing genetic data. Furthermore, the Linda approach greatly simplifies the parallelization of bioinformatics applications. Results of a DNA string searching application show very favorable performance benefits arising from the use of Java and TSpaces on a network of commodity workstations. Near-linear speedup is observed for configurations of up to 15 processors, and execution times are reduced by up to 96%.
Viruses and Hodgkin lymphoma: No evidence of polyomavirus genomes in tumor biopsies

The epidemiology of young adult Hodgkin lymphoma (HL) suggests that delayed exposure to a common childhood pathogen may be involved in disease pathogenesis. The Epstein-Barr virus (EBV) is associated with a proportion of cases but cases of young adult HL in westernized countries are less frequently EBV-associated than cases in other age groups and geographical locales. This study investigated the possibility that polyomaviruses might be involved in the etiology of HL by analysing a series of 35 cases of classical HL using both specific and degenerate PCR assays for polyomavirus genomes. No positive results were obtained, indicating that it is highly unlikely that this virus family is directly involved in the pathogenesis of HL.
Assessing Youth-Appealing Content in Alcohol Advertisements: Application of a Content Appealing to Youth (CAY) Index

ABSTRACT Underage drinking is a serious public health problem in the United States, and youth exposure to alcohol advertising has been indicated as a possible contributing factor. Although a number of studies have identified advertising content features that youth find appealing, a key limitation of this research is the absence of a broader tool to examine those features, especially those used by alcohol brands that are popular with underage drinkers. We created an index of content elements found in the research literature to be appealing to youth, and then used this index in a content analysis to identify the degree to which youth-appealing content appeared in a sample of alcohol ads that aired on television shows popular among youth. Finally, using bivariate analysis, we tested the relationship between alcohol brands’ use of this content and the popularity of those brands among youth. We found that many of the ads featured youth-appealing content, and that the ads for the alcohol brands most popular among youth had more youth-appealing content than the less popular brands.
Locomotor‐dependent and ‐independent components to hypocretin‐1 (orexin A) regulation in sleep–wake consolidating monkeys

The hypocretin system is involved in the integration of hypothalamic functions with sleep and wake. Hypocretin‐1 release peaks at the end of the active period in both diurnal and nocturnal species. A role for hypocretin‐1 in the generation of locomotor activity has been suggested by electrophysiological and neurochemical studies in rodents, dogs and cats. These species, however, do not consolidate wake into a single, daily bout and manipulations of locomotion elicit changes in wakefulness, making it difficult to parse the relative contribution of these two factors. We have examined the relationship between locomotion and hypocretin‐1 in a wake‐consolidating animal, the squirrel monkey (Saimiri sciureus). Strikingly, we found that restricting locomotion to 17% of usual activity had no significant effect on the normal diurnal rise in cerebrospinal fluid (CSF) hypocretin‐1, despite an associated increase in CSF cortisol. Increasing locomotion to greater than baseline activity did not significantly increase CSF hypocretin‐1 concentrations, but did appear to have a positive modulatory effect on CSF hypocretin‐1. In this wake‐consolidating animal, locomotion is not necessary for CSF hypocretin‐1 to increase throughout the daytime, but high levels of locomotion are likely to provide a small positive feedback onto the hypocretin system.