Miracle-dz/UniFAR-FTUs huggingface dataset:
Vasopressin cells in the medial amygdala of the rat project to the lateral septum and ventral hippocampus

The rat brain contains a large number of vasopressin (VP) immunoreactive fibers, the sites of origin of which have not yet been established completely. For instance, the sources of VP fiber systems in the amygdala, ventral hippocampus (VH), mediodorsal thalamic nucleus, ventral tegmental area, and dorsal raphe yet remain obscure. These VP fibers may originate in any of the recently described extrahypothalamic VP cell groups, viz., medial amygdaloid nucleus (AME), dorsomedial hypothalamic nucleus, or locus coeruleus, since VP efferents from these cells still remain to be demonstrated. In search of AME VP efferents three approaches were followed: (1) the Phaseolus vulgaris anterograde tracing method, (2) immunocytochemistry after AME lesioning, and (3) retrograde transport of a fluorescent dye in combination with immunofluorescence. The results demonstrate that VP cells in the AME project to (1) the lateral septum (LS) by the ventral amygdalofugal pathway and (2) the VH via the amygdalohippocampal transition zone. In addition, the VP projection from the bed nucleus of the stria terminalis (BST) to the LS was confirmed. There was no indication that VP cells in the AME project through the amygdalotegmental pathway to the medulla oblongata and spinal cord. The results support the possibility that the BST and AME are an anatomical entity that may be part of the central loci controlling sexual processes in the rat.
Aligning organizational values in systems development projects

Purpose - The purpose of this paper is to examine the antecedents and implications of aligning the organizational values embedded in a systems development approach (e.g. agile) with the organizational values of project team members. Design/methodology/approach - A qualitative case study approach is used to examine systems development project teams at three organizations, each using a development approach that incorporates different organizational value dimensions. Interviews were conducted with developers, systems analysts, and managers regarding their systems development experiences. A structured coding of the interview transcripts was then completed to enable analysis of value dimensions. Findings - By comparing the dominant values between the project teams and their development approach, varying degrees of alignment were identified. Where alignment is high, perceptions of the systems development process are associated with satisfaction and enthusiasm; where alignment is low, perceptions focus on frustration and discontent. Research limitations/implications - Based on the study's findings, four propositions pertaining to the antecedents and implications of IS values alignment are outlined for examination in future research. Practical implications - The findings from this study can aid managers who are considering the use of a new systems development approach or evaluating the effectiveness of their current approach. By determining the degree of information systems (IS) values alignment, organizations may be able to customize their development approach to be more consistent with the team's values, in order to minimize negative development process perceptions and increase project performance. Originality/value - This research extends past studies of organizational values and alignment by introducing the concept of IS values alignment.
The usefulness of carvedilol and nebivolol in preventing contrast nephropathy in rats

Abstract Background: Oxidative stress and vasoconstriction appear to be important components of contrast nephropathy (CN) pathogenesis, and both carvedilol and nebivolol are known to have vasodilatory and antioxidant effects. Aims: This study aimed to investigate whether carvedilol and nebivolol play preventive roles against developing CN and to compare the effects of each. Materials and methods: Wistar albino rats were divided into control (C, n = 6), contrast material (CM, n = 6), carvedilol (CV, n = 7), carvedilol + contrast material (CV + CM, n = 7), nebivolol (N, n = 7), and nebivolol + contrast (N + CM, n = 7) groups. Following 3 days of dehydration, 6 mL/kg diatrizoate was administered to each rat. Carvedilol was given at a dose of 2 mg/kg and nebivolol at a dose of 1 mg/kg by way of oral gavage. After scarification, total antioxidant capacity (TAC), malondialdehyde (MDA), and superoxide dismutase (SOD) were studied in renal tissue. Histopathological findings were graded as mild (+), moderate (++), and severe (+++). Results and discussion: Most of the histopathological findings and MDA levels were significantly higher in the CM group than that in the C, CVCM, and NVCM groups, whereas there was no significant difference between the C, CVCM and NVCM groups. TAC level in the CM group was significantly lower than in all other groups. There was no difference in SOD among groups. Conclusions: Carvedilol and nebivolol both prevent development of nephropathy related to CMs by decreasing oxidative stress. Neither is superior to the other.
Evaluating Research Methods on Travel Blogs

The increase of online diaries, or blogs, has not only affected communication channels, but also the way tourism destinations are being promoted and consumed. To date, few studies have focused on the content of travel blogs as a rich source of destination marketing information. A review of the current research on travel blogs revealed that the two most popular research methods used to analyze the content of online diaries are content analysis and narrative analysis. This paper provides a discussion of the strengths, weaknesses and implications of using content analysis and narrative analysis on travel blogs. After a presentation of alternative research methods on travel blogs, the authors present industry and methodological implications related to the nature of online diaries.
Inhibition of inspiratory motor output by high‐frequency low‐pressure oscillations in the upper airway of sleeping dogs

1 We utilized a chronically tracheostomized, unanaesthetized dog model to study the reflex effects on inspiratory motor output of low‐amplitude, high‐frequency pressure oscillations (HFPOs) applied to the isolated upper airway (UA) during stable non‐rapid eye movement (NREM) sleep. 2 HFPOs (30 Hz and ±2 to ±4 cmH2O) were applied via a piston pump during eupnoea, inspiratory resistive loading and tracheal occlusion. 3 When applied to the patent UA during expiration, and especially during late expiration, HFPOs prolonged expiratory time (TE) and tonically activated the genioglossus muscle EMG. When applied to the patent UA during inspiration, HFPOs caused tonic activation of the genioglossus muscle EMG and inhibition of inspiratory motor output by either: (a) a shortening of inspiratory time (TI), as inspiration was terminated coincident with the onset of HFPOs; or (b) a prolonged TI accompanied by a decreased rate of rise of diaphragm EMG and rate of fall of tracheal pressure. These effects of HFPOs were observed during eupnoea and inspiratory resistive loading, but were maximal during tracheal occlusion where the additional inhibitory effects of lung inflation reflexes were minimized. 4 During eupnoea, topical anaesthesia of the UA abolished the HFPO‐induced prolongation of TE, suggesting that the response was mediated primarily by mechanoreceptors close to the mucosal surface; whereas the TE‐prolonging effects of a sustained square wave of negative pressure (range, ‐4·0 to ‐14·9 cmH2O) sufficient to close the airway were preserved following anaesthesia. 5 These results demonstrate that high‐frequency, low‐amplitude oscillatory pressure waves in the UA, similar to those found in snoring, produce reflex inhibition of inspiratory motor output. This reflex may help maintain UA patency by decreasing the collapsing pressure generated by the inspiratory pump muscles and transmitted to the UA.
The high cost of second-line antiretroviral therapy for HIV/AIDS in South Africa

Objective:The present article estimates the cost and outcomes of second-line antiretroviral therapy. The cost of second-line drugs is generally higher than that of first-line drugs and it is expected that the absolute number of patients on second-line antiretroviral therapy will increase over time. This information is crucial for planning and budgeting. Methods:Resource utilization and outcome data were extracted for patients who initiated standard second-line therapy. Resource usage was measured from second-line initiation for 12 months and outcomes were determined at 12 months. Unit costs were applied to resource usage using standard costing techniques. Costs were classified into drug, laboratory, visit, and fixed costs. Outcomes at 12 months were determined using attendance status, diagnostic results, and treatment status. Average cost per patient and average cost per outcome were reported. Results:Of the 293 participants in the study cohort, 58% remained in care and responding, 15% were in care but not responding, and 26% were no longer in care. During the 12 months following second-line initiation, the average cost per participant was $1037. Most of the cost per patient was attributable to drugs (71%), 13% to laboratory tests, 10% to clinic and pharmacy visits, and 6% to infrastructure and other fixed costs. Second-line therapy was 2.4 times more expensive per year in care than first-line therapy. Conclusion:The gradual increase in second-line numbers that can be expected as treatment programs mature may cause a meaningful increase in the overall average cost per patient treated.
The Development of Stable Party Support: Electoral Dynamics in Post‐Communist Europe

What conditions help stable patterns of party support to emerge? Using pooled time-series cross-section data on election results from 15 East European democracies, the empirical analysis finds that (1) right after a regime change electoral volatility increases while the trend is reversed after democracy has endured for about a decade; (2) ethnic cleavages have no effect on stability while social cleavages affect electoral stability only during economic downturns; (3) both institutions and economic performance influence the stability of party support; however, the effect of the latter diminishes over time when democracies mature.
EARNINGS MANAGEMENT, INVESTOR PROTECTION, AND NATIONAL CULTURE

This paper examines the impact of investor protection and national culture on earnings management for a sample of 30 countries. The results indicate that earnings management is negatively associated with outside investor rights, consistent with Leuz et al. (2003). We also find that earnings management is relatively high in countries with high uncertainty avoidance scores and relatively low in countries where the primary language is English. Supplementary analysis of earnings management components indicates that uncertainty avoidance and masculinity are associated with earnings discretion but not with earnings smoothing. We conclude that culture is an important determinant of accounting choice and should be considered by standard setters enacting and enforcing international financial reporting rules.
Stock Markets, Banks, and Economic Growth: Empirical Evidence from the MENA Region

Over the last four decades, a wide theoretical debate is concerned with the fundamental relationship between financial development and economic growth. Recent studies shed some light on the simultaneous effect of banks and financial system development on growth rather than a separate impact. The empirical study is conducted using an unbalanced panel data from 11 MENA region countries. Econometric issues will be based on estimation of a dynamic panel model with GMM estimators. Thus, peculiarities of MENA region countries will be detected. The empirical results reinforce the idea of no significant relationship between banking and stock market development, and growth. The association between bank development and economic growth is even negative after controlling for stock market development. This lack of relationship must be linked to underdeveloped financial systems in the MENA region that hamper economic growth. Then, more needs to be done to reinforce the institutional environment and improve the functioning of the banking sector in the MENA region. Based on these results, other regions at the same stage of financial development such as Africa, Eastern Europe or Latin America should improve the functioning of their financial system in order to prevent their economies from the negative impact of a shaky financial market.
Clinicopathologic Analysis of Fas, Fas Ligand, and Other Biomarkers in Locally Advanced Breast Carcinoma

Abstract: Fas and Fas ligand (FasL) mediate T‐lymphocyte cytotoxicity and may also induce physiologic apoptosis in breast epithelium associated with menstruation and cessation of lactation. Altered expression may thus be associated with breast carcinoma progression, chemotherapy response, or outcome. We performed a clinicopathologic analysis of immunohistochemical staining for Fas and FasL, as well as bax, bcl‐2, glutathione‐s‐transferase, HER‐2 (c‐erbB‐2), Ki67, P‐glycoprotein, p53, and hormone receptors in pretreatment breast biopsies from 34 patients with locally advanced or limited stage IV breast carcinoma who received preoperative (neoadjuvant, primary) chemotherapy followed by lumpectomy or mastectomy. Neoplastic cells expressed Fas in 44% and FasL in 85% of pretreatment biopsies. Fas immunostaining was more frequent in tumors with larger size (p = 0.02) and pretreatment metastases (p = 0.03). Combined Fas and p53 staining correlated with pathologic complete response (4 of 5 CR versus 6 of 29 other, p = 0.02), as did combined p53 and lack of FasL staining (2 of 5 CR versus 0 of 29 other, p = 0.02), but individually Fas, p53, and lack of FasL immunostaining demonstrated only trends to correlation with CR (p = 0.13–0.15). No other biomarkers correlated with chemotherapeutic response. Neither FasL nor Fas expression was associated with the degree of peritumoral lymphocytic infiltration, or with expression of the other biomarkers. Recurrence was more frequent in Fas‐expressing tumors (recurrent cases 7 of 10 Fas positive versus nonrecurrent 8 of 24 Fas positive, p = 0.07). In this patient group, Fas expression is associated with aggressive tumor behavior. Biomarker immunostaining correlates weakly with pathologic response to preoperative chemotherapy, in keeping with complex or heterogeneous tumor‐drug interactions.
From English to First-Price Sealed Bid: An Empirical Assessment of the Change in Auction Type on Experienced Bidders

Abstract This paper estimate the differential impact of first-price sealed-bid (first-price) auctions relative to English auctions on auction revenue. While there is a theoretical literature on the potential outcomes of first-price relative to English auction, there is a paucity of articles that empirically estimate this relationship. The answer to this question is important not only to economists but also those designing auction for practical application. Using a unique dataset from tax lien auctions in Illinois, I empirically test the effect of a switch in auction type from English to first-price. I find auction revenue is greatly increased, by as much as 22 percent, under the first-price auction. The results are supported by a within county difference-in-difference model specification and are robust when restricting the sample across various specifications
Housing accessibility for senior citizens in Sweden: Estimation of the effects of targeted elimination of environmental barriers

Abstract Aim: To estimate the effects of targeted elimination of environmental barriers (EB) in the ordinary housing stock in Sweden, and to explore the estimated effects on accessibility at a population level in relation to (a) residents with different functional profiles, (b) different housing types and (c) building periods. Method: Data on dwellings from existing Swedish research databases were utilized. EB and accessibility were assessed by means of the Housing Enabler instrument. In simulations of EB removal, five items that correspond to the most common housing adaptations were selected. The simulations were applied to four functional profiles of different complexity. Result: EB known to be commonly removed by housing adaptations exist in large proportions of the existing ordinary housing stock. Estimated targeted elimination of selected barriers would have the largest accessibility effects for the more complex functional profiles. The effects would be consistently larger for one-family houses, and for all types of dwellings built before 1960. Conclusions: The elimination of the EB most commonly addressed by housing adaptations could result in a reduction of the housing accessibility problems that community-living older people are facing. For society to solve the housing situation for the ageing population well-informed and efficient upgrading of ordinary housing is imperative.
Experimentally reduced hip-abductor muscle strength and frontal-plane biomechanics during walking.

CONTEXT Researchers have postulated that reduced hip-abductor muscle strength may have a role in the progression of knee osteoarthritis by increasing the external knee-adduction moment. However, the relationship between hip-abductor strength and frontal-plane biomechanics remains unclear. OBJECTIVE To experimentally reduce hip-abduction strength and observe the subsequent changes in frontal-plane biomechanics. DESIGN Descriptive laboratory study. SETTING Research laboratory. PATIENTS OR OTHER PARTICIPANTS Eight healthy, recreationally active men (age = 27 ± 6 years, height = 1.75 ± 0.11 m, mass = 76.1 ± 10.0 kg). INTERVENTION(S) All participants underwent a superior gluteal nerve block injection to reduce the force output of the hip-abductor muscle group. MAIN OUTCOME MEASURE(S) Maximal isometric hip-abduction strength and gait biomechanical data were collected before and after the injections. Gait biomechanical variables collected during walking consisted of knee- and hip-adduction moments and impulses and the peak angles of contralateral pelvic drop, hip adduction, and ipsilateral trunk lean. RESULTS Hip-abduction strength was reduced after the injection (P = .001) and remained lower than baseline values at the completion of the postinjection gait data collection (P = .02). No alterations in hip- or knee-adduction moments (hip: P = .11; knee: P = .52) or impulses (hip: P = .16; knee: P = .41) were found after the nerve block. Similarly, no changes in angular kinematics were observed for contralateral pelvic drop (P = .53), ipsilateral trunk lean (P = .78), or hip adduction (P = .48). CONCLUSIONS A short-term reduction in hip-abductor strength was not associated with alterations in the frontal-plane gait biomechanics of young, healthy men. Further research is needed to determine whether a similar relationship is true in older adults with knee osteoarthritis.
The effectiveness of state of the environment reporting (SoER) at the local government sphere – a developing country's experience

State of the environment reporting (SoER) is a well-established and widely applied environmental management tool in the South African context. Despite a wealth of knowledge about conducting and preparing SoERs, there is a paucity of research on the effect SoER has had on decision-making at the local government sphere. This study investigated the effect of SoER on decision-making for a sample of municipalities in the Gauteng Province of South Africa. The methodology relied on interviews with key role players, which include the ‘‘environmental function’' as well as ‘‘other functions’' responsible for infrastructure development and planning within the municipalities. The results show that notwithstanding the extensive time and resources spent on SoER, it appears to have had a limited effect on decision-making, especially beyond the environmental function. Recommendations to improve the influence of SoER on decision-making in developing countries include improved clarity on the purpose and home of SoER within municipalities, adequate budget and capacity, and effective cooperative governance both within the municipalities, and with other spheres of government.
Best Practices and Policy Transfer in Spatial Planning

Abstract Numerous European programs and initiatives have been instrumental in identifying a large and increasing number of examples of best practice (or good practice) in the field of spatial planning. In fact, there is now a profligacy of best practice, which means that many researchers and policy-makers are often confronted with too much information when trying to identify examples of policy and practice in other places. The identification and dissemination of best practices has become a growing industry in many areas of European policy, including spatial planning and urban environmental issues. In many cases, an underlying assumption of best practices is that they are equally applicable and effective in another setting, and that the development and dissemination of best practice will help to lead to improvements in policy and practice in other countries, regions or cities. However, the reality is that best practices have a more limited role in policy-making processes: other influences are frequently more important. The value of exchanging European best practices is limited since there are huge differences in the economic, political or social situation between countries in the European Union. This is particularly true when considering the transfer of best practices between ‘new’ and ‘old’ member states, where the social and economic situation, as well as the institutional frameworks, are often very different in ‘borrowing’ and ‘lending’ countries.
Assessing the Impacts of Conservation and Commercial Forestry on Livelihoods in Northern Republic of Congo

Researchers often attempt to understand the social impacts of conservation interventions in isolation of broader socioeconomic, political and institutional change. However it is important to understand the variety of forces structuring livelihood impacts, and to identify how different social groups respond and adapt to changes. This article uses a case study from northern Republic of Congo, where rural livelihoods are shaped by a combination of conservation and commercial forestry activities, to understand the differential livelihood impacts of these activities on the two principal social groups, the Aka hunter-gatherers and Kaka and Bondongo farmer-fishers. The study results indicate that livelihood change is most striking in conservation-forestry villages compared to control villages, and this change is most evident among the Aka. Although commercial forestry is the principal driver of livelihood change, the enforcement of conservation regulations reduces households' access to natural capital and alters social relations. In this context the impacts of conservation were exacerbated due to the dramatic transformation of the livelihood space into which people were either economically displaced or chose to move to. Conservation interventions in similar contexts should involve people in the project design and initiate context-specific livelihood assessment and monitoring prior to and during the intervention.