Miracle-dz/UniFAR-FTUs huggingface dataset:
Soy Protein Isolate Protects Against Ethanol-Mediated Tumor Progression in Diethylnitrosamine-Treated Male Mice

In this study, diethylnitrosamine-treated male mice were assigned to three groups: (i) a 35% high fat ethanol liquid diet (EtOH) with casein as the protein source, (ii) the same EtOH liquid diet with soy protein isolate as the sole protein source (EtOH/SPI), (iii) and a chow group. EtOH feeding continued for 16 weeks. As expected, EtOH increased the incidence and multiplicity of basophilic lesions and adenomas compared with the chow group, P < 0.05. Soy protein replacement of casein in the EtOH diet significantly reduced adenoma progression when compared with the EtOH and EtOH/SPI group (P < 0.05). Tumor reduction in the EtOH/SPI group corresponded to reduced liver injury associated with decreased hepatic Tnfα and Cd14 antigen (Cd14) expression and decreased nuclear accumulation of NF-κB1 protein compared with the EtOH group (P < 0.05). Detection of sphingolipids using high-resolution matrix-assisted laser desorption/ionization–Fourier transform ion cyclotron resonance (MALDI-FTICR) imaging mass spectrometry revealed increased accumulation of long acyl chain ceramide species, and sphingosine-1-phosphate (S1P) in the EtOH group that were significantly reduced in the EtOH/SPI group. Chronic EtOH feeding also increased mRNA expression of β-catenin transcriptional targets, including cyclin D1 (Ccnd1), matrix metallopeptidase 7 (Mmp7), and glutamine synthetase (Glns), which were reduced in the EtOH/SPI group (P < 0.05). We conclude that soy prevents tumorigenesis by reducing proinflammatory and oxidative environment resulting from EtOH-induced hepatic injury, and by reducing hepatocyte proliferation through inhibition of β-catenin signaling. These mechanisms may involve changes in sphingolipid signaling. Cancer Prev Res; 9(6); 466–75. ©2016 AACR.
Visual Explanations from Hadamard Product in Multimodal Deep Networks

The visual explanation of learned representation of models helps to understand the fundamentals of learning. The attentional models of previous works used to visualize the attended regions over an image or text using their learned weights to confirm their intended mechanism. Kim et al. (2016) show that the Hadamard product in multimodal deep networks, which is well-known for the joint function of visual question answering tasks, implicitly performs an attentional mechanism for visual inputs. In this work, we extend their work to show that the Hadamard product in multimodal deep networks performs not only for visual inputs but also for textual inputs simultaneously using the proposed gradient-based visualization technique. The attentional effect of Hadamard product is visualized for both visual and textual inputs by analyzing the two inputs and an output of the Hadamard product with the proposed method and compared with learned attentional weights of a visual question answering model.
Identical decline of residual renal function in high-flux biocompatible hemodialysis and CAPD.

BACKGROUND Patients on conventional hemodialysis lose residual renal function more rapidly than patients on continuous ambulatory peritoneal dialysis (CAPD). The effect of dialysis using synthetic membranes and ultrapure water is less clear. METHODS The decline of urea clearance was compared in a cohort of 475 incident end-stage renal failure patients who received treatment with CAPD (N=175) or hemodialysis (HD) utilizing high-flux polysulphone membranes, ultrapure water, and bicarbonate as the buffer (N=300). RESULTS CAPD patients were significantly younger, fitter (lower comorbidity severity score), less dependent (higher Karnofsky performance score) and less likely to have presented late than HD patients. There was no difference in the mean urea clearance in each group at dialysis initiation, or at any 6-month time point during the ensuing 48 months. This was true even after exclusion of patients who had died in the first year after initiation, those transferred to another dialysis modality, or those who had been transplanted. Only age and chronic interstitial disease predicted retention of urea clearance at one year. The rate of decline of urea clearance was similar in pre- and post-dialysis initiation phases, though there may have been a step-decline of about 2 mL/min at initiation, which requires further investigation. CONCLUSIONS In hemodialysis using high-flux biocompatible membranes and ultrapure water, residual renal function declines at a rate indistinguishable from that in CAPD. This may have important implications, since preservation of residual renal function has major benefits and is a valid therapeutic goal.
From preservice teacher to emerging professional: constructing conceptualizations of teaching in a culturally diverse society

At a time when schools are becoming increasingly diverse in composition, this study explored five student teachers' perspectives on the changing role of teachers in a multicultural society. By using a constructivist framework and qualitative methodologies, interviews were conducted with student teachers in a Canadian elementary teacher education program. Two data sets consisting of one-on-one interviews were collected. The first set was collected after students had completed a thirteen week practicum. The second set was conducted after the student teachers had completed program requirements and had graduated from university with an education degree. Students' conceptualizations of the teacher's role in culturally diverse classrooms are described in six categories: bridging gaps in knowledge; being proactive as a role model; nurturing self-esteem and personal pride in heritage; focusing on care, respect, and acceptance; creating a safe and inclusive environment; resisting the lure of assimilation and the status quo. Life experiences which were influential in the formation of the students' conceptualizations are also described and organized by theme. The results of the study demonstrate that conceptualizations traversed a range of philosophical arguments outlined by theorists, and students' beliefs reflect key elements of conceptions portrayed in the approaches used to meet the needs of culturally diverse classrooms described in the literature. The findings underscore the need for multicultural theory in teacher education and for a pedagogical approach which encourages students to become reflective practitioners who are able to examine and critique personal beliefs in relation to the evolving needs of a multicultural society.
CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium*

The induction of host antimicrobial molecules following binding of pathogen components to pattern recognition receptors such as CD14 and the Toll-like receptors (TLRs) is a key feature of innate immunity. The human airway epithelium is an important environmental interface, but LPS recognition pathways have not been determined. We hypothesized that LPS would trigger β−defensin (hBD2) mRNA in human tracheobronchial epithelial (hTBE) cells through a CD14-dependent mechanism, ultimately activating NF-κB. An average 3-fold increase in hBD2 mRNA occurs 24 h after LPS challenge of hTBE cells. For the first time, we demonstrate the presence of CD14 mRNA and cell surface protein in hTBE cells and show that CD14 neutralization abolishes LPS induction of hBD2 mRNA. Furthermore, we demonstrate TLR mRNA in hTBE cells and NF-κB activation following LPS. Thus, LPS induction of hBD2 in hTBE cells requires CD14, which may complex with a TLR to ultimately activate NF-κB.
The Influence of Otolith Dysfunction on the Clinical Presentation of People With a Peripheral Vestibular Disorder

Background and Purpose Traditional vestibular function testing has measured horizontal semicircular canal function only. Otolith function tests have recently been developed, but their clinical significance has not been determined. The purpose of this study was to investigate the influence of otolith dysfunction on the clinical presentation of individuals with a peripheral vestibular disorder. Subjects and Methods Twenty-one subjects with loss of horizontal semicircular canal function only and 37 subjects with combined loss of horizontal semicircular canal and otolith organ function were recruited. All subjects received a comprehensive clinical assessment, including self-report questionnaires and measures of balance performance. Results No significant differences were identified between subjects with or without otolith dysfunction with respect to symptom severity, self-perceived handicap, functional limitations, or balance performance. Discussion and Conclusion Otolith dysfunction does not significantly influence the clinical presentation of individuals with a peripheral vestibular disorder. Other factors, including symptom severity, may be more influential.
Empty Sites can Promote Altruistic Behavior

Abstract Spatial structure has been shown to promote altruistic behavior, however, it also increases the intensity of competition among relatives. Our purpose here is to develop a model in which this competition is minimized, more precisely a local increase in fecundity has a minimal competitive effect on the fitness of nearby individuals. We work with an island model in which sites are allowed to be empty, choosing our demographic rules so that in patches with higher fecundity, empty sites are filled at a higher rate. We also allow dispersal rates to evolve in response to the proportion of empty sites in the patch. Patches with different numbers of empty sites differ in frequency, in within-patch consanguinity, and in reproductive value. Using an inclusive fitness argument, we show that our model does promote altruism; indeed Hamilton's Rule is shown to hold. The only negative effect on an actor of a gift of fecundity to a patchmate turns out to be a slight decrease in reproductive value due to an increased probability of an empty site being occupied. We show that altruists are most favored in islands with an intermediate number of empty sites.
Contact with Human Facilities Appears to Enhance Technical Skills in Wild Vervet Monkeys (Chlorocebus aethiops)

Technical abilities of primates are typically tested in the laboratory. It has been argued that close contact between animals and humans may lead to an increase in skills due to an ‘enculturation’ of subjects. Here, we provide evidence that exposure to human facilities may improve wild vervet monkeys’ technical skills in a social learning task using the ‘artificial fruit’ approach. Two of our 6 study groups had access to human facilities within their territories. Only members of these 2 groups were likely to open successfully ‘artificial fruit’ during their first attempt. Success appeared to be independent of individual sex or the type of task. Our results highlight the possibility that human enculturation may allow captive monkeys to acquire more technical skills than their wild counterparts, and we suggest that this possibility should be tested in further field experiments.
The nature of choice and value for services and amenities in Australian universities

In two decades, Australian university students have accumulated over $25 billion in debt, a figure that is expected to increase dramatically over the next few years. The literature has rarely considered students’ attitudes about ancillary services and amenities, despite their importance to the character of university life and substantial contribution to rising student debt. This case study examines the attitudes and concerns of students regarding the compulsory fees for non-teaching services and amenities levied at an Australian university. Using a concept analysis and mapping technique, this case study highlights significant concerns among students regarding the benefits of services and amenities, and low involvement in the co-creation of value. Drawing on service co-creation topologies, the study identifies market opportunity and further reforms that could facilitate a more sustainable, responsive and dynamic service provision environment, in the context of the Australian and international higher education.
A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions

A continuous systematic review of all combinations of drugs and suspected adverse reactions (ADRs) reported to a spontaneous reporting system, is necessary to optimize signal detection. To focus attention of human reviewers, quantitative procedures can be used to sift data in different ways. In various centres, different measures are used to quantify the extent to which an ADR is reported disproportionally to a certain drug compared to the generality of the database. The objective of this study is to examine the level of concordance of the various estimates to the measure used by the WHO Collaborating Centre for International ADR monitoring, the information component (IC), when applied to the dataset of the Netherlands Pharmacovigilance Foundation Lareb.
Regularised Model Identification Improves Accuracy of Multisensor Systems for Noninvasive Continuous Glucose Monitoring in Diabetes Management

Continuous glucose monitoring (CGM) by suitable portable sensors plays a central role in the treatment of diabetes, a disease currently affecting more than 350 million people worldwide. Noninvasive CGM (NI-CGM), in particular, is appealing for reasons related to patient comfort (no needles are used) but challenging. NI-CGM prototypes exploiting multisensor approaches have been recently proposed to deal with physiological and environmental disturbances. In these prototypes, signals measured noninvasively (e.g., skin impedance, temperature, optical skin properties, etc.) are combined through a static multivariate linear model for estimating glucose levels. In this work, by exploiting a dataset of 45 experimental sessions acquired in diabetic subjects, we show that regularisation-based techniques for the identification of the model, such as the least absolute shrinkage and selection operator (better known as LASSO), Ridge regression, and Elastic-Net regression, improve the accuracy of glucose estimates with respect to techniques, such as partial least squares regression, previously used in the literature. More specifically, the Elastic-Net model (i.e., the model identified using a combination of and norms) has the best results, according to the metrics widely accepted in the diabetes community. This model represents an important incremental step toward the development of NI-CGM devices effectively usable by patients.
‘OK, well, first of all, let me say …’: Discursive uses of response initiators in US presidential primary debates

This article examines the discursive uses of frequent response initiators by Republican and Democratic presidential candidates in the genre of televised US primary debates. Ten full transcripts of debates held between February and April 2016 are investigated from the perspectives of political discourse studies and conversation analysis. It is shown that the response initiators well, first of all, look, you know and let me (just) speech act verb fulfill specific discursive functions in competitive media discourse. On the textual level, candidates exert power and control by negotiating turn-taking processes and managing the information flow. On the interactional level, competitors use response initiators to frame themselves as likable and competent personas, to establish common ground with voters and to enhance negative perceptions of opponents. Conclusively, in the multilogue of election debates, response initiators significantly contribute to the construction of individual preferability.
Endoscopic techniques to detect small-bowel neuroendocrine tumors: A literature review

Background The diagnosis of small-bowel neuroendocrine tumors (SbNETs) has improved with the advent of video capsule endoscopy (CE) and double-balloon enteroscopy (DBE). The data describing the efficacy of CE/DBE in the detection of SbNETs are scanty. Aim The aim of this article is to review the current evidence on the role of DBE and CE in the diagnosis of SbNETs. Material and methods A bibliographical search was performed in PubMed using the following keywords: “neuroendocrine tumors and enteroscopy/and capsule endoscopy” and “small bowel neuroendocrine tumors. ” Results CE and DBE can be complementary and show a similar diagnostic yield. The number of false-negative results has not been established yet because of the “work-up bias” observed in the majority of the studies. Conclusions DBE and CE appear to be both safe and effective procedures useful in the diagnosis of SbNETs. Further studies are required to clarify their potential complications and relationship with other techniques, particularly nuclear imaging.
Prospective comparison of preference and efficacy of adalimumab and infliximab for treating ulcerative colitis naive to antitumor necrosis factor therapy

Abstract There have been few reports on 2 tumor necrosis factor alpha inhibitors, infliximab and adalimumab, with respect to patient preference and efficacy in ulcerative colitis (UC). We used questionnaires to evaluate the preference and reasons for drug choice between infliximab and adalimumab in UC patients naive to antitumor necrosis factor alpha therapy. We also analyzed the efficacy of infliximab and adalimumab prospectively and endoscopically before treatment and at 14 and 54 weeks. Of the 25 UC patients, infliximab and adalimumab were chosen by 10 (40%) and 15 (60%), respectively. Patients who favored infliximab considered “fear of syringes” (7/10, 70%) as the most important influencing factor, whereas patients who favored adalimumab considered “ease of administration” (10/15, 66.7%) and “time required for therapy” (10/15, 66.7%) as the most important factors. There were no statistical differences in remission induction and maintenance between the infliximab and adalimumab groups with regard to response, remission, mucosal healing, steroid-free, and steroid-free remission rates at weeks 14 and 54. The efficacy of adalimumab in remission induction and maintenance was equivalent to that of infliximab in UC patients naive to antitumor necrosis factor alpha therapy in this prospective study, but more patients preferred adalimumab.
Isolation, Characterization and Expression Analysis of a Leaf-specific Phosphoenolpyruvate Carboxylase Gene in Oryza sativa

Suppression subtractive hybridization was carried out to enrich gene fragments over-expressed in rice leaves by subtraction to rice roots, from which two identical cDNA fragments were identified to encode putative phosphoenolpyruvate carboxylase. Then the corresponding full-length cDNA (Osppc) is isolated by RT-PCR and sequenced, which indicates an open reading frame of 2895 bp is contained. Its deduced protein is encoded in 10 exons and shows high similarity to many other plant PEPCs. Comparing with maize and bacterial PEPCs, it is revealed that OSPPC shares many conserved domains and active sites that responsible for the structure, activity and regulation of this enzyme. Phylogenetic analysis demonstrates that OSPPC is grouped with C3 form PEPCs of wheat, maize and sorghum, which is consistent with the classification of rice. And a putative promoter element is predicted with DOF binding box, CAAT box and TATA box in the 5′-flanking sequence of Osppc gene. Moreover, Quantitative RT-PCR analyses are performed in hybrid rice and its parents, which show that Osppc is specifically expressed in leaf including leaf vein and sheath.
The Underlying Factors Of Rural-Urban Migration In Southeastern Nigeria : A Study In Nsukka Region Of Enugu State

This research appraised the underlying factors of rural-urban migration in southeastern Nigeria with focus on Nsukka Region of Enugu state. It utilized the survey research design which involved the use of household questionnaires in data collection. The study covered 4 local government areas, 16 communities and 910 households. Data analysis was done with Principal Component Analysis (PCA). The PCA identified five underlying push factors of migration in the region to include: presence of impelled migration; poor income generating opportunities; escaping unfavourable conditions; transfer as a factor of migration and escaping conflict and insecurity of life. PCA result equally showed seven underlying dimensions that pull migrants to urban destinations namely: seek improved economic status; accessible destinations; join spouse; seek greater development; stay with relations; enjoy more convivial environment and engage in politics. it is found that the strength of push and pull factors are almost equal as determinants of rural-urban migration in the region as each of these groups of factors exert approximately 61% of pressure on the migrant to migrate out of the rural areas of the study area and also to in-migrate to the urban areas. Among the recommendations is that special incentives be offered to private firms and companies that locate in the rural areas of the region to boost employment opportunities and so downgrade rural out-migration.
Effects of tramadol, morphine or their combination in dogs undergoing ovariohysterectomy on peri-operative electroencephalographic responses and post-operative pain

Abstract AIM: To compare the peri-operative electroencephalogram (EEG) responses and post-operative analgesic efficacy of pre-operative morphine or tramadol with a combination of low-dose pre-operative morphine and post-operative tramadol, in dogs undergoing ovariohysterectomy. METHODS: Dogs undergoing routine ovariohysterectomy were treated with either pre-operative morphine (0.5 mg/kg S/C, n=8), or tramadol (3 mg/kg S/C, n=8), or pre-operative low-dose morphine (0.1 mg/kg S/C) and post-operative tramadol (3 mg/kg I/V, n=8). All dogs received routine pre-anaesthetic medication, and anaesthesia was induced with I/V thiopentone to effect and maintained with halothane in oxygen. Respiratory rate, heart rate, end-tidal halothane tension (EtHal) and end-tidal CO2 tension (EtCO2) were monitored throughout surgery. The EEG was recorded continuously in a three electrode montage. Median frequency (F50), total power (Ptot) and 95% spectral edge frequency (F95) of the EEG power spectra were compared during different 100-second periods of surgery: prior to and during skin incision, ligation of each ovarian pedicle, ligation of uterine body and skin closure. Post-operatively, pain was assessed using the short form of the Glasgow composite measure pain scale (CMPS-SF). RESULTS: There was no difference in F50 or Ptot of the EEG between baseline and noxious surgical events within each treatment group, or between the three groups (p>0.05). The mean F95 was higher during the first three periods of surgery for dogs administered tramadol and low-dose morphine than those that received 0.5 mg/kg morphine (p=0.001). Dogs that received low-dose morphine and tramadol had lower CMPS-SF pain scores after ovariohysterectomy than those that received either tramadol or morphine alone (p=0.001). There was no difference in pain scores between dogs in the latter two groups. CONCLUSION AND CLINICAL RELEVANCE: Tramadol and morphine administered pre-operatively provided an equal degree of post-operative analgesia in dogs after ovariohysterectomy. A combination of pre-operative low-dose morphine and post-operative tramadol produced better post-operative analgesia than either drug administered alone pre-operatively. Administration of analgesics pre- and post-operatively could result in improved post-operative well-being of ovariohysterectomised dogs.