Miracle-dz/UniFAR-FTUs huggingface dataset:
Three-level buck converter for envelope tracking applications

This letter proposes a three-level buck converter for tracking applications such as envelope-tracking in radio frequency power amplifiers (RFPAs). It is shown that the three-level buck converter can offer advantages in terms of switching ripples, losses, bandwidth, or the size of magnetic components compared to a standard buck or a two-phase buck converter. Experimental results illustrate improved efficiency and ripple rejection in an RFPA envelope-tracking application representative for low-power battery-operated systems.
Hereditary Absence of Sebaceous Glands in the Mouse

An autosomal recessive mutation, characterized by an absence of sebaceous glands, and by hyperkeratosis, alopecia, and single (rather than the usual multiple) hair-follicle units, has occurred spontaneously in the BALB/c strain of mouse. Studies in which reciprocal transplantations of skin were made between normal and mutant mice suggest that some diffusible substance(s) synthesized by normal skin can stimulate hair growth and alleviate the hyperkeratosis characteristic of the skin syndrome.
Reliability of a field-based drop vertical jump screening test for ACL injury risk assessment

Abstract Objectives: There is an epidemic of anterior cruciate ligament (ACL) injuries in youth athletes. Poor neuromuscular control is an easily modifiable risk factor for ACL injury, and can be screened for by observing dynamic knee valgus on landing in a drop vertical jump test. This study aims to validate a simple, clinically useful population-based screening test to identify at-risk athletes prior to participation in organized sports. We hypothesized that both physicians and allied health professionals would be accurate in subjectively assessing injury risk in real-time field and office conditions without motion analysis data and would be in agreement with each other. Methods: We evaluated the inter-rater reliability of risk assessment by various observer groups, including physicians and allied health professionals, commonly involved in the care of youth athletes. Fifteen athletes age 11–17 were filmed performing a drop vertical jump test. These videos were viewed by 242 observers including orthopaedic surgeons, orthopaedic residents/fellows, coaches, athletic trainers (ATCs), and physical therapists (PTs), with the observer asked to subjectively estimate the risk level of each jumper. Objective injury risk was calculated using normalized knee separation distance (measured using Dartfish, Alpharetta, GA), based on previously published studies. Risk assessments by observers were compared to each other to determine inter-rater reliability, and to the objectively calculated risk level to determine sensitivity and specificity. Seventy one observers repeated the test at a minimum of 6 weeks later to determine intra-rater reliability. Results: Between groups, the inter-rater reliability was high, κ = 0.92 (95% CI 0.829–0.969, p < 0.05), indicating that no single group gave better (or worse) assessments, including comparisons between physicians and allied health professionals. With a screening cutoff isolated to subjects identified by observers as “high risk”, the sensitivity was 63.06% and specificity 82.81%. Reducing the screening cutoff to also include jumpers identified as “medium risk” increased sensitivity to 95.04% and decreased the specificity to 46.07%. Intra-rater reliability was moderate, κ = 0.55 (95% CI 0.49–0.61, p < 0.05), indicating that individual observers made reproducible risk assessments. Conclusions: This study supports the use of a simple, field-based observational drop vertical jump screening test to identify athletes at risk for ACL injury. Our study shows good inter- and intra-rater reliability and high sensitivity and suggests that screening can be performed without significant training by physicians as well as allied health professionals, including: coaches, athletic trainers and physical therapists. Identification of these high-risk athletes may play a role in enrollment in appropriate preventative neuromuscular training programs, which have been shown to decrease the incidence of ACL injuries in this population.
Analysis of 473 US Head and Neck Cancer Trials (1996-2014)

Objective To report on types of investigations being conducted in US clinical trials, the types of therapeutic investigations that predominate, and the publication rates. Study Design Retrospective analysis. Settings US head and neck cancer clinical trials. Subjects and Methods We used the information available on ClinicalTrials.gov to identify trends in head and neck squamous cell carcinoma clinical trials to characterize the types of trials and treatments being investigated. The publication rate for these trials was also examined with PubMed.gov. Results Of the 473 trials analyzed, similar drug regimens have been used repeatedly in head and neck cancer clinical trials. Drug studies are highly represented, composing 62% of all trials. The most common drugs studied were cisplatin, cetuximab, and docetaxel. Among all head and neck cancer clinical trials, 33% included radiation therapy in their treatment, while 10% included a surgical component. Forty-nine percent of trials had their results published in a medical journal, and 70% of the publications reported positive results. Conclusion Head and neck cancer trials are heavily weighted toward drug trials and demonstrate redundancy. Other therapies are underrepresented, especially surgery. There is a gap between the trials conducted and the rate of reporting, with an emphasis on positive results. Better balance in studying treatment modalities, less redundancy in clinical trials, and reporting all results have potential benefits for head and neck cancer and the public good.
Simultaneous effects of estradiol on TSH secretion and adrenocortical function in male and female rats.

Sex differences in TSH secretion and adrenal function were revealed in adult male and female Sprague-Dawley rats after chronic administration (14 days) of estradiol benzoate (EB). The effect of the steroid on the pituitarythyroid and adrenocortical systems was dose dependent. Relatively little change in the various indices of adrenal function (gland weight, plasma and adrenal corticosteroids) was seen in the female rat with all dose levels of EB treatment (.1, 1, 10 and 50 μg daily). TSH content of the enlarged pituitary progressively declined, however. Plasma TSH titers also fell. This was accompanied by histological alterations indicative of reduced secretion in the thyroid. The response of the adrenal in estradiol-treated male rats was biphasic. Lower doses (10 and 50 μg) produced adrenal hypertrophy and sharp elevation in plasma and adrenal corticosteroid concentrations. With higher doses of EB (150 μg), all indices of adrenal activity remained normal. TSH content of plasma and adenohypophysis was not.
Allelic imbalance study of 16q in human primary breast carcinomas using microsatellite markers

The high incidence of allelic imbalance on the long arm of chromosome 16 in breast cancer suggests its involvement in the development and progression of the tumor. Several loss of heterozygosity (LOH) studies have led to the assignment of commonly deleted regions on 16q where tumor suppressor genes may be located. The most recurrent LOH regions have been 16q22.1 and 16q22.4‐qter. The aim of this study was to gain further insight into the occurrence of one or multiple “smallest regions of overlap” on 16q in a new series of breast carcinomas. Hence, a detailed allelic imbalance map was constructed for 46 sporadic breast carcinomas, using 11 polymorphic microsatellite markers located on chromosome 16. Allelic imbalance of one or more markers on 16q was shown by 30 of the 46 tumors (65%). Among these 30 carcinomas, LOH on the long arm of chromosome 16 was detected at all informative loci in 19 (41%); 13 of them showed allelic imbalance on the long but not on the short arm, with the occurrence of variable “breakpoints” in the pericentromeric region. The partial allelic imbalance in 11 tumors involved either the 16q22.1‐qter LOH region or interstitial LOH regions. A commonly deleted region was found between D16S421 and D16S289 on 16q22.1 in 29 of the 30 tumors. The present data argue in favor of an important involvement of a tumor suppressor gene mapping to 16q22.1 in the genesis or progression of breast cancer.
Comparisons of the ILU(0), Point-SSOR, and SPAI Preconditioners on the CRAY-T3E for Nonsymmetric Sparse Linear Systems Arising from PDEs on Structured Grids

When solving general sparse linear systems, multicoloring techniques can yield a parallelism of order N, where N is the dimension of the matrix. However, this strategy often suffers from the deterioration of the rate of convergence, as in the preconditioned conjugate gradient method. Another technique that does not suffer from this deterioration of the rate of convergence is the wavefront technique, which exploits parallelism that is available in the original matrix. The rate of convergence remains the same, but the maximum parallelism is limited by the length of the wavefronts, which are often nonuniform. Another popular technique is the sparse approximate inverse (SPAI) technique, capturing the inverse in the sparse form, which is very nice for parallel computation. In this paper, the author compares these two approaches of ILU(0), SPAI, and point-SSOR preconditioners using the BICGSTAB method as the outer iterative method on the CRAY-T3E. It was found that for the problems tested, ILU(0) with multicoloring outperforms the other alternatives.
Comparison of Seven Formulae and Isoelectrofocusing for Determination of Intrathecally Produced IgG in Neurological Diseases

Seven different formulae and agarose isoelectrofocusing (AIF) using immunolabelling for IgG were compared for their ability to discriminate between intrathecally produced IgG and transudated IgG in cerebrospinal fluid. All reference limits were set to a specificity of 97·5% (reference group, n = 211). The probability of a positive test (p +) was evaluated for 112 patients with multiple sclerosis (MS), 42 with meningitis, 114 with noninflammatory diseases affecting the central nervous system (CNS), 23 with Guillain-Barré syndrome, and 56 with various diseases not affecting the CNS. Agarose isoelectrofocusing had the best diagnostic sensitivity (93%) for MS, combined with a low p + (0–19%) for other diseases. Among the formulae, the IgG extended index and Reiber's hyperbolic formula were equivalent, giving high (75–79%) diagnostic sensitivity for MS combined with low p + (4–22%) for other diseases. All other formulae, although sensitive for MS, had a higher rate of false positive results.
Efficacy of Cetuximab in Metastatic Castration-Resistant Prostate Cancer Might Depend on EGFR and PTEN Expression: Results from a Phase II Trial (SAKK 08/07)

Purpose: The EGF receptor (EGFR) is overexpressed in the majority of metastatic castration-resistant prostate cancers (mCRPC) and might represent a valid therapeutic target. The combination of docetaxel and cetuximab, the monoclonal antibody against EGFR, has not been tested in patients with prostate cancer. Experimental Design: Patients with mCRPC progressing during or within 90 days after at least 12 weeks of docetaxel were included in this phase II trial. Treatment consisted of docetaxel (75 mg/m2 every 3 weeks or 35 mg/m2 on days 1, 8, 15 every 4 weeks) in combination with cetuximab (400 mg/m2 on day 1 and then 250 mg/m2 weekly). The primary endpoint was progression-free survival (PFS) at 12 weeks defined as the absence of prostate-specific antigen (PSA), radiographic, or clinical progression. Evaluation of known biomarkers of response and resistance to cetuximab (EGFR, PTEN, amphiregulin, epiregulin) was conducted. Results: Thirty-eight patients were enrolled at 15 Swiss centers. Median age was 68 years and median PSA was 212 ng/mL. PFS at 12 weeks was 34% [95% confidence interval (CI), 19%–52%], PFS at 24 weeks was 20%, and median overall survival (OS) was 13.3 months (95% CI, 7.3–15.4). Seven patients (20%) had a confirmed ≥50% and 11 patients (31%) a confirmed ≥30% PSA decline. About 47% of enrolled patients experienced grade 3 and 8% grade 4 toxicities. A significantly improved PFS was found in patients with overexpression of EGFR and persistent activity of PTEN. Conclusions: EGFR inhibition with cetuximab might improve the outcome of patients with mCRPC. A potential correlation between EGFR overexpression, persistent expression of PTEN, and EGFR inhibition should be investigated further. Clin Cancer Res; 18(21); 6049–57. ©2012 AACR.
Physiological and perceptual strain of firefighters during graded exercise to exhaustion at 40 and 10 °C

Purpose. To study whether perceptual identification should be included as a measure to evaluate physiological stress. Methods. Physiological variables oxygen uptake (VO2), ventilation, heart rate, blood lactate concentration, rectal temperature (Trec) and mean skin temperature, and perceptual variables rate of perceived exertion, thermal sensation and time to exhaustion, were measured at submaximal and maximal intensities during graded exercise on a treadmill to exhaustion in 12 firefighters wearing protective clothing and extra mass at 40 and 10 °C. Physiological strain index (PhSI) and perceptual strain index (PeSI) were calculated. Results. Apart from Trec, all physiological and perceptual variables were higher at submaximal intensities of 40 °C. Time to exhaustion was 16% shorter and the corresponding VO2 was reduced by 7% in the heat. A high correlation (r = 89) between PhSI and PeSI was found at both temperatures. PeSI scores were equal to PhSI at both ambient temperatures, except at the two highest intensities in the heat, where PeSI was higher. Conclusions. These findings support use of perceptual identification to evaluate physiological stress. However, at very high intensities under hot conditions the perceptual strain was estimated higher than the physiological strain. More precise indexes are needed to include perceptual measures in safety standard.
Three-dimensional Motion Tracking for Beating Heart Surgery Using a Thin-plate Spline Deformable Model

Minimally invasive cardiac surgery offers important benefits for the patient but it also imposes several challenges for the surgeon. Robotic assistance has been proposed to overcome many of the difficulties inherent to the minimally invasive procedure, but so far no solutions for compensating physiological motion are present in the existing surgical robotic platforms. In beating heart surgery, cardiac and respiratory motions are important sources of disturbance, hindering the surgeon’s gestures and limiting the types of procedures that can be performed in a minimally invasive fashion. In this context, computer vision techniques can be used for retrieving the heart motion for active motion stabilization, which improves the precision and repeatability of the surgical gestures. However, efficient tracking of the heart surface is a challenging problem due to the heart surface characteristics, large deformations and the complex illumination conditions. In this article, we present an efficient method for active cancellation of cardiac motion where we combine an efficient algorithm for 3D tracking of the heart surface based on a thin-plate spline deformable model and an illumination compensation algorithm able to cope with arbitrary illumination changes. The proposed method has two novelties: the thin-plate spline model for representing the heart surface deformations and an efficient parametrization for 3D tracking of the beating heart using stereo images from a calibrated stereo endoscope. The proposed tracking method has been evaluated offline on in vivo images acquired by a DaVinci surgical robotic platform.
Intra‐arterial bolus octreotide administration during Whipple procedure in patients with fragile pancreas: A novel technique for safer pancreaticojejunostomy

Leakage from the pancreaticojujenostomy is the most serious complication of Whipple. Pancreatic fistula rate is higher in cases of fragile pancreas often seen in duodenal carcinomas and carcinomas of the ampulla of Vater. Octreotide administration has been used for the prevention of fistula formation through the subcutaneous route. Due to its physiologic effects to the pancreatic parenchyma the intra‐arterial administration of octreotide could provide tissue hardening that allows for a technically easier anastomosis while maintaining its protective role for fistula formation.
Functional Results of the First Human Double-Hand Transplantation

Objective Objective of this study was to analyze fifteen months after surgery the sensorimotor recovery of the first human double hand transplantation. Summary Background Data As for any organ transplantation the success of composite tissue allografts such as a double hand allograft depends on prevention of rejection and its functional recovery. Methods The recipient was a 33-year-old man with bilateral amputation. Surgery included procurement of the upper extremities from a multiorgan cadaveric donor, preparation of the graft and recipient's stumps; then, bone fixation, arterial and venous anastomoses, nerve sutures, joining of tendons and muscles and skin closure. Rehabilitation program included physiotherapy, electrostimulation and occupational therapy. Immunosuppressive protocol included tacrolimus, prednisone and mycophenolate mofetil and, for induction, antithymocyte globulins and then CD25 monoclonal antibody were added. Sensorimotor recovery tests and functional magnetic resonance imaging (fMRI) were performed to assess functional return and cortical reorganization. All the results were classified according to Ipsen's classification. Results No surgical complications occurred. Two episodes of skin acute rejection characterized by maculopapular lesions were completely reversed increasing steroid dose within 10 days. By fifteen months the sensorimotor recovery was encouraging and the life quality improved. fMRI showed that cortical hand representation progressively shifted from lateral to medial region in the motor cortex. Conclusion Even though at present this double hand allograft, treated using a conventional immunosuppression, allowed to obtain results at least as good as those achieved in replanted upper extremities, longer follow-up will be necessary to demonstrate the final functional restoration.
Clinicopathologic and Immunohistochemical Features and Microsatellite Status of Endometrial Cancer of the Uterine Isthmus

To clarify the clinicopathologic, molecular, and immunohistochemical characteristics of uterine isthmic endometrial cancer (UIE), we examined 13 cases of UIE and compared them with 33 cases of endometrial cancer of the uterine corpus (UCE) with respect to clinicopathologic factors, the expression of p53, the estrogen receptor (ER) and the progesterone receptor (PR) status, DNA ploidy, and microsatellite instability (MSI). Five (38.4%) of the UIE patients had stage I, two (15.4%) had stage II, and six (46.2%) had stage III disease (FIGO 1988). Myometrial invasion was confirmed in 92.3% of the UIE patients, and these patients had a higher (p<0.05) frequency of >50% myometrial invasion (46.2%) than the patients with UCE (15.2%). Moreover, the UIE patients had a higher frequency of positive peritoneal cytology (p<0.05) and pelvic lymph node metastases (p<0.05). No UIE tumors exhibited MSI, and the tumors in these patients had a higher expression of p53 (p<0.01), a lower expression of ER (p<0.05) and PR (p<0.05), and a higher frequency of DNA aneuploidy (p<0.01) than the UCE tumors. These findings suggest that the UIE is clearly different from UCE in the clinicopathologic, immunohistochemical features, and microsatellite status.
Structural and functional responses of river biofilm communities to the nonsteroidal anti‐inflammatory diclofenac

Diclofenac is a nonsteroidal anti‐inflammatory drug (NSAID) that has been detected widely in surface waters in North America and Europe. The impact of diclofenac on river biofilm communities was investigated at exposures of 10 and 100 μg L−1 of diclofenac or its molar equivalent in carbon and nutrients. Experiments were carried out with river water during spring and summer using rotating annular reactors as model systems. Diclofenac or nutrients at 10 μg L−1 were observed to have no significant effect on algal, bacterial, and cyanobacterial biomass in spring, whereas in the summer the nutrient equivalent reduced algal biomass and diclofenac reduced cyanobacterial biomass relative to control biofilms (p < 0.05). In contrast, at 100 μg L−1 diclofenac or nutrients, the result was increased cyanobacterial and bacterial biomass, respectively, relative to control biofilms in spring. In summer, 100 μg L−1 diclofenac significantly increased bacterial biomass and the nutrient treatment had no significant effect (p < 0.05); both treatments resulted in increased biofilm thickness. The glycoconjugate composition of the exopolysaccharide matrix was influenced differentially by the treatments in both seasons. Biolog assessments of carbon use indicated that 100 μg L−1 diclofenac or nutrients resulted in significant depressions in the use of carbon sources in summer and significant increases in spring. Impacts on protozoan and micrometazoan populations also were assessed. Denaturing gradient gel electrophoresis analyses of community DNA and fluorescent in situ hybridization studies indicated that diclofenac had significant effects on the nature of the bacterial community in comparison with control and nutrient‐treated river biofilm communities.
Hepatitis a seroprevalence in children and young adults in Istanbul, Turkey: seroprevalence change and associated factors

Summary. Hepatitis A is a widespread infectious disease. The prevalence of the disease is closely related to socioeconomic status (SES) and environmental factors. Understanding its prevalence is essential for instituting appropriate precautions. The aim of this study was to determine the prevalence of hepatitis A and evaluate the associated demographic features in children and young adults in Istanbul. In total, 630 individuals between the ages of 5–24 were included in the study. They were classified into four age groups (5–9, 10–14, 15–19 and 20–24 years). The seropositivity of hepatitis A in the whole study population was 40%. Age‐specific prevalence was 11.4% in children 5–9 years old, 29% in those 10–14 years old, 49.7% in those 15–19 years old and 69% in those 20–25 years old. Seropositivity was associated with increasing age, low SES, large family size, low maternal educational level, use of unsafe drinking water and living in regions with poor infrastructure and incomplete urbanization. When we compared our results with previous seroprevalence studies performed in Istanbul, we found an epidemiological shift towards increasing age. Factors associated with changes in prevalence were urbanization and associated infrastructure improvement, knowledge of the disease by the population, use of good hygiene and use of vaccination in those at high risk.
Impaired event memory and recollection in a case of developmental amnesia

A current debate in the literature is whether all declarative memories and associated memory processes rely on the same neural substrate. Here, we show that H.C. , a developmental amnesic person with selective bilateral hippocampal volume loss, has a mild deficit in personal episodic memory, and a more pronounced deficit in public event memory; semantic memory for personal and general knowledge was unimpaired. This was accompanied by a subtle difference in impairment between recollection and familiarity on lab-based tests of recognition memory. Strikingly, H.C. 's recognition did not benefit from a levels-of-processing manipulation. Thus, not all types of declarative memory and related processes can exist independently of the hippocampus even if it is damaged early in life.