Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of flexural slip in the development of chevron folds

Chevron folds are characterized by straight limbs and narrow hinge zones. One of the conceptual models to initiate and develop chevron folds involves flexural slip during folding. While some kinematical models show the necessity for slip to initiate during chevron folding, recent numerical modeling studies of visco-elastic effective single layer buckle folding have shown that flexural slip does not result in chevron folds. In this study, several 2D finite element analysis models are run, distinguished by 1) geometry of the initial perturbation (sinusoidal and white noise), 2) varying thewavelength of the initial perturbation (10%, 50%, and 100% of the dominant wavelength) and 3) variation of the friction coefficient (high and low friction coefficient between interlayers). All numerical simulations apply 60% of shortening, in order to achieve inter-limb angles of 60 to 70 degrees. The results show that for sinusoidal initial perturbations, systematic and symmetric chevron folds are reproduced when 10% of the dominant wavelength is used for the initial perturbation. Using 50% or 100% of the dominant wavelength results in circular and sinusoidal folds, respectively. Low friction coefficient models result in larger amplitudes and sharper inter-limb angles compared to high friction coefficient models. For white noise initial perturbations, isolated and asymmetric chevron folds are developed when the friction coefficient is low. High friction coefficient models reproduce the dominant wavelength without chevron folds and low friction coefficient models result in a different dominant wavelength. In all chevron folds models, slip initiates at the early stages of folding (i.e. 1% to 5% of shortening).
Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice

The cell-penetrating peptide GV1001 has been investigated as an anticancer agent and recently demonstrated anti-oxidant and anti-inflammatory effects. It has shown a protective effect on a kanamycin (KM)-induced ototoxicity mouse model. In the present study, we administered GV1001 at different time points after inducing hair cell damage, and examined if it rescues hair cell loss and restores hearing. A deaf mouse model was created by intraperitoneal injection of KM and furosemide. First, to test the early temporal change of hearing and extent of hair cell damage after KM and furosemide injection, hearing and outer hair cells (OHCs) morphology were evaluated on day 1, day 2 and day 3 after injection. In the second experiment, following KM and furosemide injection, GV1001, dexamethasone, or saline were given for three consecutive days at different time points: D0 group (days 0, 1, and 2), D1 group (days 1, 2, and 3), D3 group (days 3, 4, and 5) and D7 group (days 7, 8, and 9). The hearing thresholds were measured at 8, 16, and 32 kHz before ototoxic insult, and 7 days and 14 days after KM and furosemide injection. After 14 days, each turn of the cochlea was imaged to evaluate OHCs damage. GV1001-treated mice showed significantly less hearing loss and OHCs damage than the saline control group in the D0, D1 and D3 groups (p < 0.0167). However, there was no hearing restoration or intact hair cell in the D7 group. GV1001 protected against cochlear hair cell damage, and furthermore, delayed administration of GV1001 up to 3 days rescued hair cell damage and hearing loss in KM/furosemide-induced deaf mouse model.
A Mobile-Based Communication Adoption Model for agricultural market information dissemination in Uganda

This study proposes a mobile-based communication adoption model for agricultural market information dissemination in Uganda. An extended Unified Theory of Acceptance and Use of Technology model was used to guide the study. A survey was conducted on 302 commercial farmers and agribusiness traders in Eastern Uganda using self-administered questionnaires. Data were analyzed using descriptive statistics; Structural Equation Modelling was also used to perform confirmatory tests analyses on study variable relationships and to develop the proposed model. Findings reveal a positive significant relationship between Performance Expectancy and Behavioral Intentions to use; Effort Expectancy and Behavioral Intentions to use; Social influence and Behavioral intention to use; Behavioral intention to use and adoption of mobile-based communication technologies. However, the relationship between affordability of mobile-based communication technologies and behavioral intentions to use and the relationship between facilitating conditions and adoption of mobile-based communication technologies were dropped by the structural equation model because they had negative path coefficients. Effective adoption of Mobile-Based Communication Technologies for Agricultural Information Dissemination in Uganda can be achieved with stakeholders increasing on the functionality and the ease of use of these mobile-based communication technologies; provide nationwide sensitization campaigns on benefits of using mobile-based communication technologies; ensure provision of accurate and reliable agricultural market information by mobile based communication technologies, provide benefits to members of society so as to convince others to use mobile-based communication technologies.
Differential Impact of Depressive and Manic Mood States on Alcohol Craving in Comorbid Bipolar Alcoholism: Preliminary Findings

Objectives:To examine the differential impact of depressive and manic mood states on alcohol craving in patients with bipolar disorder and comorbid alcoholism. Materials and Methods:Forty-four men and women, aged 18 to 65 years, with DSM-IV-TR comorbid diagnoses of bipolar I disorder and alcohol dependence were assessed over a 3-month period to examine the extent to which their depressive and manic symptoms were associated with alcohol cravings (ie, desire to use and not to use alcohol) at each assessment point, controlling for age, ethnicity, socioeconomic status, baseline alcohol use, and number of assessments. Results:Both manic and depressive symptoms were associated with greater desire to use alcohol. Only depressive symptomatology was associated with reduced desire not to use alcohol, and desire not to use alcohol declined over the course of the 3-month treatment period. Conclusions:Whereas enhanced desire to drink alcohol may be a conditioned reaction to both manic and depressed mood states, desire not to drink alcohol may be more of an indicator of treatment motivation, which is negatively affected by depressed mood. Depressive symptoms may warrant prioritization and aggressive targeting early in treatment given that desire to refrain from alcohol use was only influenced by depressive symptoms and declined over the course of treatment.
Comparison of backbone dynamics of monomeric and domain‐swapped stefin A

Three‐dimensional domain swapping has been observed in increasing number of proteins and has been implicated in the initial stages of protein aggregation, including that of the cystatins. Stefin A folds as a monomer under native conditions, while under some denaturing conditions domain‐swapped dimer is formed. We have determined the backbone dynamics of the monomeric and domain‐swapped dimeric forms of stefin A by 15N relaxation using a model‐free approach. The overall correlation times of the molecules were determined to be 4.6 ± 0.1 ns and 9.2 ± 0.2 ns for the monomer and the dimer, respectively. In the monomer, decreased order parameters indicate an increased mobility for the N‐terminal trunk, the first and the second binding loops. At the opposite side of the molecule, the loop connecting the α‐helix with strand B, the beginning of strand B and the loop connecting strands C and D show increased localized mobility. In the domain‐swapped dimer, a distinctive feature of the structure is the concatenation of strands B and C into a single long β‐strand. The newly formed linker region between strands B and C, which substitutes for the first binding loop in the monomer, has order parameters typical for the remainder of the β‐strands. Thus, the interaction between subunits that occurs on domain‐swapping has consequences for the dynamics of the protein at long‐range from the site of conformational change, where an increased rigidity in the newly formed linker region is accompanied by an increased mobility of loops remote from that site. Proteins 2004. © 2004 Wiley‐Liss, Inc.
What is an intention to treat analysis?

Randomization and allocation concealment are key methodological aspects in the design and conduct of comparative clinical trials (www.consort-statement.org). Random allocation generates treatment groups that are very similar in terms of known and unknown characteristics and, consequently, allows to reach correct conclusions about the true effect of an intervention under study. However, randomisation means little if investigators cannot include all randomly assigned participants in the primary analysis (Schulz & Grimes, 2002). Theoretically, statistical analyses should consider all patients according to their allocation as designated by the randomization procedure. This approach is called intention-to-treat analysis (ITT analysis). In the Figure it is reported the flow diagram of an hypothetical study that randomly allocated 100 patients per arm. At the end of the study period 39 (treatment A) and 46 responders (treatment B) were observed.
Addition of Advanced Practice Registered Nurses to the Trauma Team: An Integrative Systematic Review of Literature

The total cost of inpatient care from a traumatic mechanism of injury in the United States between 2001 and 2011 was $240.7 billion. Medical resident work hour reductions mandated in 2011 left a shortage of available in-hospital providers to care for trauma patients. This created gaps in continuity of care, which can lead to costly increased lengths of stay (LOS) and increased medical errors. Adding advanced practice nurses (APNs) specializing in acute or trauma care to the trauma team may help fill this shortage in trauma care providers. The purpose of this integrative systematic review of the literature was to determine whether adding APNs to the admitting trauma team would decrease LOS. A systematic review of primary research in CINAHL and PubMed databases was performed using the following terms: nurse practitioner, advanced practice nurse, trauma team, and length of stay. Included studies examined the effects of adding APNs to trauma teams, were written in English, and were published in 2007–2017. Six studies were included in the final sample, and all were completed at Level I trauma centers in the United States except one from Canada. Combined sample size was 25,083 admitted trauma patients. All 6 studies reported a decrease in LOS ranging from 0.8 to 2.54 days when APNs were added to the trauma team. More research is needed to identify the best utilization of an APN on a trauma team. It is recommended that all trauma centers add APNs to the trauma team to not only decrease admitted trauma patients' LOS but also provide continuity of care, decreasing costs, and minimizing errors.
Hubungan Work Engagement dengan Turnover Intention: Studi Pada Karyawan PT. X

Intisari. Penelitian ini dilatarbelakangi oleh tingginya kasus turnover yang selama ini terjadi di beberapa perusahaan di Bali. Tujuan dari penelitian ini untuk mengetahui ada atau tidaknya hubungan negatif antara work engagement dengan turnover intention serta melihat aspek dari work engagement yang memiliki hubungan negatif paling tinggi terhadap turnover intention. Penelitian ini dilakukan di PT. X Bandara Internasional Ngurah Rai Bali. Metode pengambilan data dilakukan dengan observasi, wawancara, serta pengisian angket yang terdiri dari dua skala terhadap responden. Work engagement diukur dengan menggunakan skala yang diadopsi dari skala pengukuran work engagement bernama Utrecht Work Engagement Scale (UWES). Turnover intention diukur dengan skala. Sampel dalam penelitian ini adalah karyawan yang bekerja di PT. X dengan status kontrak serta memiliki masa kerja di bawah tiga tahun. Hasil penelitian menunjukkan bahwa terdapat hubungan negatif antara work engagement dengan turnover intention. Sementara aspek dari work engagement yang memiliki hubungan negatif paling dekat dengan turnover intention adalah dedication (dedikasi). Kata Kunci: Work Engagement, Turnover Intention, Karyawan.
Predictive Biomarkers and Personalized Medicine p 53 Expression in Node-Positive Breast Cancer Patients : Results from the Cancer and Leukemia Group B 9344 Trial ( 159905 )

Purpose: p53 as a prognostic and predictive factor in early-stage breast cancer has hadmixed results. We studied p53 protein expression, by immunohistochemistry, in a randomized clinical trial of stage II patients treated with adjuvant doxorubicin and cyclophosphamide with or without paclitaxel [Cancer and Leukemia Group B (CALGB) 9344, INT0148]. Patients and Methods: Epithelial p53 expression was evaluated using two immunohistochemical antibodies (DO7 and 1801) in formalin-fixed, paraffin-embedded tissue from patients with node-positive breast cancer who were randomized to four cycles of cyclophosphamide and one of three doses of doxorubicin (60, 75, or 90 mg/m; AC) and to receive four subsequent cycles of paclitaxel (T) or not. Prognostic and predictive value of p53 protein expression was assessed, independent of treatment assignment, for escalating doses of doxorubicin or addition of T with endpoints of relapse-free (RFS) and overall survival (OS). Results: Of 3,121 patients, 1,887 patient specimens treated on C9344 were obtained, passed quality control, and evaluated for p53 expression. Expression was 23% and 27% for mAbs 1801 and D07, respectively, with 92% concordance. In univariate analysis, p53 positivity was associated with worse OS with either antibody, but only p53 staining with monoclonal antibody 1801 had significantly worse RFS. In multivariate analysis, p53 was not predictive of RFS or OS from either doxorubicin dose escalation or addition of paclitaxel regardless of the antibody. Conclusion: Nuclear staining of p53 by immunohistochemistry is associated with worse prognosis in node-positive patients treated with adjuvant doxorubicin-based chemotherapy but is not a useful predictor of benefit from doxorubicin dose escalation or the addition of paclitaxel. Clin Cancer Res; 17(15); 5170–8. 2011 AACR.
Neural Tube Defects in the North of Jordan: Is There a Seasonal Variation?

Neural tube defects are serious birth defects of the brain and the spinal cord due to interference with neural tube closure about the 28th day after fertilization. Seasonal variation in the development of neural tube defects has been reported. The objective of this study was to demonstrate any association between the season of conception and the development of neural tube defects in the north of Jordan. For a 7-year period between January 2000 and December 2006, data of 78 neonates born with neural tube defect were analyzed regarding dates of conception in relation to the development of neural tube defects. More affected babies were conceived in the late summer and early autumn. The study demonstrated that seasonality affected the incidence of neural tube defects in the north of Jordan.
Quantitative wearable sensors for objective assessment of Parkinson's disease

There is a rapidly growing interest in the quantitative assessment of Parkinson's disease (PD)‐associated signs and disability using wearable technology. Both persons with PD and their clinicians see advantages in such developments. Specifically, quantitative assessments using wearable technology may allow for continuous, unobtrusive, objective, and ecologically valid data collection. Also, this approach may improve patient‐doctor interaction, influence therapeutic decisions, and ultimately ameliorate patients' global health status. In addition, such measures have the potential to be used as outcome parameters in clinical trials, allowing for frequent assessments; eg, in the home setting. This review discusses promising wearable technology, addresses which parameters should be prioritized in such assessment strategies, and reports about studies that have already investigated daily life issues in PD using this new technology. © 2013 International Parkinson and Movement Disorder Society
Dyspnea, ventilatory pattern, and changes in dynamic hyperinflation related to the intensity of constant work rate exercise in COPD.

STUDY OBJECTIVE We undertook the present study to investigate the perception of dyspnea (with respect to changes in end-inspiratory and end-expiratory lung volumes), during four different levels of high-intensity constant work rate exercise (CWRE) in patients with severe COPD. DESIGN Crossover descriptive study with consecutively recruited subjects. SETTING Tertiary university hospital. PATIENTS Twenty-seven subjects with severe COPD (mean [+/- SD] age, 65 +/- 5 years of age; mean FEV1, 43 +/- 8% predicted; and mean inspiratory capacity [IC]; 74 +/- 14% predicted). MEASUREMENTS AND RESULTS Subjects randomly performed four high-intensity CWRE tests (conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate). Dyspnea, leg fatigue, and IC were determined every 2 min during exercise with breath-by-breath gas exchange and ventilatory measurements. There was a good correlation between the resting IC percent predicted and the oxygen uptake (V(O2)) peak (r = 0.64 to 0.69 between the IC percent predicted and V(O2) peak at the four work rates). There were significant differences (p < 0.01) in mean respiratory rate (33 +/- 6, 35 +/- 6, 37 +/- 6, and 38 +/- 6 min), peak dyspnea score (5.9 +/- 1.3, 6.3 +/- 1.4, 6.8 +/- 1.2, and 6.9 +/- 1.6), minute ventilation (45.0 +/- 8.7, 43.8 +/- 7.7, 43.1 +/- 8.7, and 42.8 +/- 8.0 L/min), leg fatigue (4.8 +/- 1.3, 5.1 +/- 1.3, 5.7 +/- 1.4, and 5.8 +/- 1.4), and end-tidal carbon dioxide partial pressure (4.41 +/- 0.36, 4.53 +/- 0.33, 4.66 +/- 0.31, and 4.76 +/- 0.24 kPa), respectively, for tests conducted at 65%, 75%, 85%, and 95% of their symptom-limited peak work rate, and in mean end-expiratory lung volume ([EELV] 4.55 +/- 0.44, 4.69 +/- 0.43, and 4.79 +/- 0.43 L), respectively, for tests conducted at 65%, 75%, and 85% of their symptom-limited peak work rate. In multivariable analysis, the factors that were independently correlated with dyspnea (p < 0.05) were EELV, peak inspiratory flow, and leg fatigue/discomfort. CONCLUSION In COPD subjects with flow limitation at rest, the perception of dyspnea increased nonlinearly with the magnitude of high-intensity CWRE in association with a faster respiratory pattern and an increase in EELV. At the highest work rates, it appeared that a reduction in tidal volume and ventilation peak may have limited the tolerance to exercise.
Time-Changed Lévy LIBOR Market Model: Pricing and Joint Estimation of the Cap Surface and Swaption Cube

We propose a novel time-changed Levy LIBOR (London Interbank Offered Rate) market model for jointly pricing of caps and swaptions. The time changes are split into three components. The first component allows matching the volatility term structure, the second generates stochastic volatility, and the third accommodates for stochastic skew. The parsimonious model is flexible enough to accommodate the behavior of both caps and swaptions. For the joint estimation we use a comprehensive data set spanning the financial crisis of 2007–2010. We find that, even during this period, neither market is as fragmented as suggested by the previous literature.
Intravenous OxyContin‐associated thrombotic microangiopathy treated successfully without plasma exchange

A 56-year-old man of European ancestry with no clinically significant medical history presented with a 3-day history of periumbilical abdominal pain. He admitted to daily intravenous (IV) misuse of oral extended-release oxycodone hydrochloride (OxyContin; Mundipharma) over a period of months. For the 5 weeks before presentation, he had been injecting the new tamper-resistant formulation because he was unable to access the discontinued crushable form.
Worst-case robust beamforming for wireless relay networks with direct link

In this paper, worst-case robust beamforming to minimize the transmit power with quality of service (QoS) constraint is investigated for wireless relay networks with direct link. To be practical, channel errors are assumed for all the links including source-to-relay, relay-to-destination, and direct source-to-destination links. The signals coming from the relay link and direct link are combined by maximum ratio combining based on the channel estimates. After identifying the worst cases of the total transmit powers at the relays and the signal-to-noise-ratio (SNR) at the receivers, the beamforming problem is reformulated and an iterative algorithm is proposed to solve the robust beamforming based on semi-definite relaxation. Sim- ulation results demonstrate that the proposed beamforming can significantly reduce the transmit power while guarantee the QoS.
Multidisciplinary, Interdisciplinary, or Dysfunctional? Team Working in Mixed-Methods Research

Combining qualitative and quantitative methods in a single study—otherwise known as mixed-methods research—is common. In health research these projects can be delivered by research teams. A typical scenario, for example, involves medical sociologists delivering qualitative components and researchers from medicine or health economics delivering quantitative components. We undertook semistructured interviews with 20 researchers who had worked on mixed-methods studies in health services research to explore the facilitators of and barriers to exploiting the potential of this approach. Team working emerged as a key issue, with three models of team working apparent: multidisciplinary, interdisciplinary, and dysfunctional. Interdisciplinary research was associated with integration of data or findings from the qualitative and quantitative components in both the final reports and the peer-reviewed publications. Methodological respect between team members and a principal investigator who valued integration emerged as essential to achieving integrated research outcomes.
Performance of Vitek 2 for Antimicrobial Susceptibility Testing of Enterobacteriaceae with Vitek 2 (2009 FDA) and 2014 CLSI Breakpoints

ABSTRACT Vitek 2 (bioMérieux Inc., Durham, NC) is a widely used commercial antimicrobial susceptibility test system. We compared the MIC results obtained using the Vitek 2 AST-GN69 and AST-XN06 cards to those obtained by CLSI broth microdilution (BMD) for 255 isolates of Enterobacteriaceae, including 25 isolates of carbapenem-resistant Enterobacteriaceae. In total, 25 antimicrobial agents were examined. For 10 agents, the MIC data were evaluated using two sets of breakpoints: (i) the Vitek 2 breakpoints, which utilized the 2009 FDA breakpoints at the time of the study and are equivalent to the 2009 CLSI M100-S19 breakpoints, and (ii) the 2014 CLSI M100-S24 breakpoints. There was an overall 98.7% essential agreement (EA). The categorical agreement was 95.5% (CA) using the Vitek 2 breakpoints and 95.7% using the CLSI breakpoints. There was 1 very major error (VME) (0.05%) observed using the Vitek 2 breakpoints (cefazolin) and 8 VMEs (0.5%) using the CLSI breakpoints (2 each for aztreonam, cefepime, and ceftriaxone, and 1 for cefazolin and ceftazidime). Fifteen major errors (MEs) (0.4%) were noted using the Vitek 2 breakpoints and 8 (0.5%) using the CLSI breakpoints. Overall, the Vitek 2 performance was comparable to that of BMD for testing a limited number of Enterobacteriaceae commonly isolated by clinical laboratories. Ongoing studies are warranted to assess performance in isolates with emerging resistance.