Miracle-dz/UniFAR-FTUs huggingface dataset:
Title Modulation of COX 2 and hTERT expression by PhotodynamicTherapy in human colon cancer cells

Photodynamic therapy (PDT) was employed as a cancer therapy with photosensitizer (PS)-loaded cancer cells, eradicated by the reactive oxygen species after light activation. Cyclo-oxygenase 2 (COX2) is an enzyme expressed in 80% of colon adenocarcinoma and is one of the targets for effective cancer treatment. There is also uprising evidence that the human telomerase reverse transcriptase (hTERT), a catalytic component of telomerase, is reported as a promising indicator for monitoring cancer treatment. In this study, NPe6 mediated PDT on COX2 induced apoptosis in HT-29 was investigated. The cell cycle changes was analysed by flow cytometry and the hTERT expression at pre and post PDT was evaluated at transcription level by Taqman real time PCR. NPe6-PDT in HT-29 cells demonstrated anti-proliferating effect in a drug and light dose dependent manner. LD50 was achieved at 16μg/mL and 2J/cm at 4 hour-post treatment with a significant down-regulation of COX2 expression at LD30 and LD50 by immunohistochemical staining (IHC) (p<0.05, One-Way ANOVA). Membrane blebbing was detected Photodynamic Therapy: Back to the Future, edited by David H. Kessel, Proc. of SPIE Vol. 7380, 738065 · © 2009 SPIE · CCC code: 1605-7422/09/$18 · doi: 10.1117/12.823084 Proc. of SPIE Vol. 7380 738065-1 Downloaded From: http://proceedings.spiedigitallibrary. org/ on 12/29/2014 Terms of Use: http://spiedl.org/terms in over 60% of cells. 35.2% of treated cells arrested in S-phase at LD50 after 24 hours by flow cytometry. A 0.25and 0.6-fold down-regulation of hTERT mRNA expression was achieved at LD30 and LD50 respectively by TaqMan real-time PCR. To summarize, NPe6 mediated PDT down-regulated COX2 expression and triggered cell apoptosis. The hTERT can serve as an indicative marker for monitoring NPe6-PDT cancer treatment efficacy.
Effect of Fermentation and Particle Size of Wheat Bran on the Antinutritional Factors and Bread Quality

3 Abstract: Three local sudanese wheat cultivars, Debeira, El-Nielain and Sasaraib were obtained from Agricultural Research Corporation (harvest season 2002/03). Wheat bran was obtained from a local flour mill in Khartoum North. It was carefully sieved and classified as coarse, medium and fine bran size then fermented. Proximate composition, mineral content and anti-nutritional factors (tannin, phytic acid) were determined for all types of wheat bran. Results indicated that fermentation of wheat bran increased the percentage of crude fiber from 15.67 to 18.67%, 15.67 to 18.00%, 15.00 to 17.67%, protein content from 20.35 to 21.65%, 18.36 to 20.79%, 21.07 to 22.40% for coarse, medium and fine wheat brans, respectively. Carbohydrates percentage increased from 45.09 to 47.4% in fermented coarse wheat bran. Both anti- nutritional factors (tannins and phytic acid) were found to decrease significantly (P<0.05) in coarse, medium and fine wheat bran. The tannin content decreased from 0.03 to 0.01, 0.07 to 0.05 and from 0.07 to 0.06 mg catechin/100 gm, respectively. Phytic acid decreased from 626.1 to 572.8, 740.4 to 367.1 and from 795.2 to 301.6 mg/100 gm, respectively. There is no change on the values of Ca and Fe contents of coarse wheat bran after fermentation. Also there was an increase in Ca content of fine and medium wheat bran. Fe content of medium wheat bran decreased from 0.03 to 0.02% but Fe content of fine wheat bran increased from 0.023 to 0.033%. There is a slight decrease in P content of coarse wheat bran after fermentation. The phosphorous content as percentage decreased in fermented medium and fine wheat bran from 0.004 and 0.003% to 0.002 and . 002%, respectively. Bread specific volume values of the three cultivars with 10, 15 and 20% fermented wheat bran decreased with increase in the amount of wheat bran. Bread with 10% fermented coarse wheat bran gave the best results for all characteristics tested in organolyptic evaluation.
Proposal of a simplified method for pastoral value assessment inside forest planning

Carrying capacity is one of the most important variables that should be assessed for a proper evaluation of forage potentiality of pastures. Nevertheless, inside forest management plans, reduced costs make impossible the involvement of additional technical staff specialized in this domain and for this reason different methodologies to simplify data collection were proposed for pasture planning. In this paper a simplified method to evaluate the pastoral value (one of the most common procedure for carrying capacity estimation) is proposed and assessed in real conditions in order to obtain a proper potential stocking rate of a whole pasture area. The method is based on a previous research that proposed a simplified method of data collection that is performed by means of different functional groups of species or botanical families: palatable grasses, not palatable grasses, legumes, species belonging to other botanical families, spiny and poisonous species, trees and shrubs. Each category is linked to its feeding behavior by an index that summarizes forage potentiality and this permits to classify the resources in different quality classes, each of them characterized by a given potential stocking rate. The proposed methodology seems easy to be performed also by staff without a specific formation in pasture management and comparison performed with the traditional procedure produced accurate results. Even if the proposed scheme should not to be considered alternative to the original methodology, it can be useful to acquire information for pastoral resource management, especially at territorial level.
Risk factors related to human papillomavirus infection in oral squamous cell carcinoma

Background: In addition to tobacco and alcohol consumption, some infectious pathogens such as human papillomavirus (HPV) have been proposed as carcinogenic factors in oral cancer. Objective: The objective of the study is to assess the possible influence of HPV detection in oral squamous cell carcinoma (OSCC). Materials and Methods: A PubMed search through April 2018, using the following Medical Subject Headings terms, was performed: “mouth neoplasms” and “papillomavirus infections. ” Studies with findings on HPV detection in OSCCs were assessed. From 77 studies with full-text availability, 59 were excluded for several reasons: no usable/irrelevant data (32), tonsils, base of tongue and non-OSCC cases studies (26), and animal testing studies (1). The data were analyzed using statistical software RevMan 5.3 (The Cochrane Collaboration, Oxford, UK). For dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios (ORs) using Haenszel–Mantel method with 95% confidence intervals. Results: Eighteen studies on HPV detection in OSCCs were included in this meta-analysis. The mean percentage of HPV detection in OSCC was 37.1%. Oral cancer patients showed a higher risk of being infected with HPV than controls (OR: 4.85) and they were more likely to be infected with high-risk HPV (OR: 11.46). A larger number of smokers had HPV-infected tumors (OR: 1.45). Younger age, gender, tobacco and/or alcohol consumption, tumor differentiation degree, tumor size (T-status), and lymph node metastasis (N-status) were factors that did not have a significant influence on HPV-infected oral cancers. Conclusion: HPV infection, especially of high-risk HPV, is more frequent in patients with OSCC.
Biometrics, ageing, sexing and moult of the Blue Chaffinch Fringilla teydea teydea on Tenerife (Canary Islands)

The Blue Chaffinch Fringilla teydea is one of a few Palearctic species for which biometric data are lacking from the field; we address this issue here. Blue Chaffinches were caught by mist net, at ten sites on Tenerife (Canary Islands), and measured. Data on biometrics and moult using standard methods are presented, and observations on mass variation in relation to time of day and body size are reported for the first time. Wing length, bill length, bill depth & tail were greater in adults and first year birds than juveniles whilst tarsus and mass were the same. The species shows a clear sexual dimorphism in size except for bill length. The duration of primary moult was estimated to be 66 days for adults. For first year birds (in their second‐calendar year), the mean starting date of primary moult was 25 days earlier than adults and was completed after 109 days.
Derivation and validation of a formula for paediatric tracheal tube size using bootstrap resampling procedure

Background and Aims: The accuracy of age-, length- and weight-based formulae to predict optimal size of uncuffed tracheal tubes (TTs) in children varies widely. We determined the accuracy of age, length and weight in predicting the size of TT in Indian children, and derived and validated a formula using the best predictor. Methods: In the derivation phase, 100 children aged 1-8 years undergoing general anaesthesia and tracheal intubation with an uncuffed tube were prospectively studied. The correct size of the TT used was confirmed using the leak test. A bootstrap resampling procedure was used to estimate the accuracy of the predictors (age, weight, or length alone; length and age; length and weight; and length, weight and age). The best predictor was used to derive a formula (Paediatric Tube Size Predictor, PTSP) to calculate the size of TT. The accuracy of PTSP was tested in 150 children of the same age group in the validation phase. Results: Length (L (in meters), R2 = 0.61) was the best single predictor of the size of TT and was used to derive the PTSP as internal diameter = 3L + 2.5. In the validation phase, the PTSP predicted the size of TT correctly in 75% of children. Re-intubation was associated with a higher incidence of respiratory morbidity than one-time tracheal intubation. Conclusion: Length of the child predicts the size of an uncuffed TT better than age and weight. The PTSP formula based on length correctly predicts the size of uncuffed TT in 75% of children.
Involvement of inhibitory control mechanisms in overcoming intuitive interference

Many students encounter difficulties in science and mathematics that may stem from intuitive interference of salient irrelevant variables. We focused on the comparison of perimeters task, in which area is the irrelevant salient variable. In congruent trials (no interference), accuracy is higher and reaction time is shorter than in incongruent trials (area variable interference). A brain-imaging study related to this task indicated that correctly answering the incongruent condition is associated with activation in prefrontal brain regions known for their executive inhibitory control. In the current study we explored the relationship between inhibitory control mechanisms and the ability to overcome intuitive interference. Participants in the study were 90 ninth graders. The efficiency of their inhibitory control mechanisms was assessed and accuracy and reaction time of correct responses in the comparison of perimeters task were recorded. The findings indicate that students with efficient inhibitory control mechanisms scored significantly better in the incongruent conditions than did those with inefficient ones. In addition, the findings indicate that the higher the efficiency of inhibitory control mechanisms, the better students were in overcoming the intuitive interference. These findings indicate the importance of inhibitory control mechanisms in overcoming interference in science and mathematics. They point to the possibility of improving students’ ability to overcome intuitive interference by strengthening their inhibitory control mechanisms. We also demonstrate that applying cognitive psychology and neuroscience methodologies in science and mathematics education research contributes to both fields. 1 Tel Aviv University, The Constantiner School of Education, Department of Science Education, Tel Aviv, 69978, Israel 2 Tel Aviv University, The Sagol School of Neuroscience, Tel Aviv, 69978, Israel *Author email address: reuvenb@post.tau. ac.il To cite this article: Babai, R. , Younis, N. , & Stavy, R. (2014). Involvement of inhibitory control mechanisms in overcoming intuitive interference. Neuroeducation, 3(1), 1-9. https://doi.org/10.24046/neuroed.20140301. 1 Received October 14, 2014. Received in revised form December 16, 2014. Accepted in January 12, 2015. Available online March 6, 2015. Neuroeducation, 3(1), 1-8 ISSN: 1929-1833 All rights reserved © 2014 Association pour la recherche en neuroéducation / Association for Research in Neuroeducation R. Babai, N. Younis, & R. Stavy Inhibitory control mechanisms in overcoming intuitive interference NEUROEDUCATION 2014 | Volume 3 | Number 1 2
Tilting lattices over orders associated with simple modules

Let R be a complete discrete valuation ring with quotient field K and A a basic R-order in a separable /f-algebra,and let e be a primitive idempotent of A. In this paper we shall study tilting^-latticesin the form of T={l―e)A (BTr/X/e) where / is the Jacobson radical of A and Trz,is the transpose functor for yl-lattices. Tilting theory was initiated by Brenner and Butler [5] and its general theory over artin algebras was given in Happel and Ringel [6] and Bongartz [4] and has been used and developed by many authors not only in the study of representations of artin algebras but also in more general situations. Among them tilting modules arising from suitable simple modules are concrete and typical ones (see [2] and [5]). While almost all general results in [4] are reconstructed in the case of orders by Roggenkamp [8], it seems also to be desirable to provide an order version of such tilting modules and study its fundamental properties, which is the aim of this paper. In Section 1, we shall recall some definitions and notation which will be used throughout the paper. In Section 2, we shall show that T=(l―e)A 0 TrL(/e) is a tilting. //-lattice if and only if Je is not J-reflexive and Ae is not isomorphic to a direct summand of the projective cover of Je (Theorem 2.1). We call such a tilting. //-lattice Brenner-Butler type (BB-type for short). We shall also show that T is a tiltingJ-lattice of BB-type if and only if T is a tiltingleft /"-latticeof BB-type and J=Endr(T) where T=End^(T) (Theorem 2.4). As an application of Theorem 2.1 we shall show that a non-hereditary, basic tiled R-order of finite global dimension always has tiltinglattices of BBtype (Proposition 2.5). As a special class of BB-type, in Section 3, we shall introduce the notion of tiltinglattices of Auslander-Platzeck-Reiten type (APRtype for short), which arise from almost splitsequences starting from certain projective modules. It should be noted that in the case of orders we cannot consider simple projective modules. We shall replace simplicity by injectivity of its radical. (See Theorem 3.1.)In Section 4, we shall precisely describe the
Are stock Market Reactions Related to Future Operational Performance? A study on acquisitions in Europe

We investigate the markets’ ability to predict post-acquisition operational performance for 41 acquisitions made in Western Europe between 2002 and 2012. The methodology builds on Healy et al (1992). We find that on average there exists a positive relation between the market reaction during an acquisition window and the operational outcome. The relation is found when observing the changes in operating cash flows. Furthermore results show that changes in cash flows can be allocated to changes in the cost structure. The methodology is extended by observing how the shareholders of the bidding and the targeted firms are affected separately. The results show that shareholders of the targeted firms are more beneficial than the shareholders of the bidding firms. We do not find any significant relation between increased value to the shareholders of the bidding firm and increased cash flows. Moreover we find that bidding firms tend to pay at least the value of future potential synergies. Our results imply that the premium paid for targets can be seen as a good approximation for potential synergies captured through an acquisition.
Allergy asthma practice in India: Beyond the guidelines “Shivpuri Oration 2017”

This article summarizes two decades of allergy and asthma research in Mysore, South India, encompassing epidemiologic, mechanistic and biomarker studies as well as diagnostic and prognostic studies. The deficiencies of some of the current guidelines in the diagnosis and treatment of allergic diseases. Two of the most important considerations for future guidelines are to adopt the concept of progression of allergic disease and discuss plans to prevent or mitigate them to reduce the burden of morbidity as well as the enormous costs that go along with disease progression. The other is to consider serial spirometry for the diagnosis of asthma and COPD in difficult to diagnose subjects. The future directions for research in the field are discussed.
Experimental and theoretical correlation of very intense visible green photoluminescence in BaZrO3 powders

Very intense visible green photoluminescence (PL) was observed at room temperature in structurally ordered-disordered BaZrO3 powders. Ab initio calculations, ultraviolet-visible absorption spectroscopy, electron paramagnetic resonance, and PL were performed. Theoretical and experimental results showed that local defects in the cubic structure caused by [ZrO5⋅VOz] complex clusters, where VOz=VOx, VO•, and VO••, play an important role in the formation of hole-electron pairs, giving rise to a charge gradient in the structure which is responsible for PL emission.
The effect of body weight on the incidence and prevalence of hypertension in Yaoundé

The prevalence of obesity and its related complications are on the increase in the industrialized as well as developing nations. This study assesses prevalence of hypertension, the influence of body weight on blood pressure variation and the relationship between obesity and hypertension in Yaoundé. A descriptive, cross-sectional study was conducted in 5 757 participants (61.6% females; mean age 33.7 ± 10.3 years old and 38.4% males; mean age 33.0 ± 11.5 years old) participated in health campaign program. Weight classification was done according to WHO criteria as 18.5 >BMI 24.9 (normal); 25 BMI 29.9 (overweight) and BMI 30 (obese). High blood pressure was recorded following both the National Cholesterol Education Program (ATP III) and World Health Organization criteria. Out of the 5757 participants, 34.5% were normal weight, 31.7% were overweight and 33.8% were obese individuals. Using the NCEP and WHO criteria respectively, diastolic high blood pressure was observed in 43% and 32.8% of participants. A positive correlation was found between BMI and both diastolic and systolic blood pressure. This study showed that there was a strong association of BMI with blood pressure and a high prevalence of diastolic hypertension among obese participants. The present result underpins the need for a consistent national emphasis on prevention and control of hypertension and obesity in younger adults.
Anticipation, Acquisitions and Bidder Returns: Industry Shocks and the Transfer of Information Across Rivals

We document market anticipation of merger bids and show that less anticipated bids earn significantly higher announcement returns. Subsequent bidders in the industry experience significant and positive abnormal returns around the time of initial industry bid announcements. These results suggest that announcement period returns underestimate the wealth effects of bidding. After accounting for anticipation, bidding activity is, on average, a significant wealth-creating event. Moreover, bidders pursuing public targets increase shareholder wealth and bidders in stock swaps do not lose. These results contradict conventional wisdom. Our results shed light on the correct magnitude of acquisition returns and on the transfer of information throughout an industry around the time of an economic shock. The Author 2011. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. , Oxford University Press.
Primary localized cutaneous amyloidosis – A clinicopathological study

Introduction: Cutaneous amyloidosis can be a manifestation of a systemic disorder or can result from localized process confined to the skin. Involvement of apparently normal skin is known as primary localized cutaneous amyloidosis. Histopathologically, amyloid appears as amorphous, eosinophilic material with hematoxylin and eosin stain. Congo red staining with apple-green birefringence under polarized microscopy confirms the diagnosis. Materials and Methods: Thirty-nine patients with a differential diagnosis of cutaneous amyloidosis reporting to the dermatology outpatient department of our hospital from November 2015 to May 2018 were studied. Twenty-six cases showed features of amyloidosis on histopathology. These were categorized into morphologic types of amyloidosis and correlated with the available clinical history. Congo red staining and observation under polarized microscope were done. Results: We encountered lichen and macular types of cutaneous amyloidosis with slight female predominance. Majority of the lesions were pruritic with involvement of the pretibial region. A history of friction was given by a few. All cases diagnosed clinically were concordant histopathologically. However, a single case of lichen amyloidosis was diagnosed solely based on histology. Microscopically, hyperkeratosis, amyloid deposits in the papillary dermis, and perivascular inflammation were the most consistent findings. All the cases showed apple-green birefringence with Congo red stain under polarized microscope. Conclusion: Cutaneous amyloidosis can have a wide range of differential diagnosis due to its varied clinical presentation. Histopathology, with the use of special stains, helps in identifying amyloid with a high degree of accuracy.
Aesthetic emotions and the evaluation of architectural design styles

The research studied aesthetic emotions and their relationship to architectural design styles. The goal was to see how people assess two contrasting design styles, namely Renaissance and Contemporary styles, by considering aesthetic and emotional aspects. Participants were 35 students, who were presented with 10 digitalized images of building facades of both architectural styles, projected on a computer screen. They were requested to assess each picture using a semantic questionnaire containing 11 bipolar themes organized into 4 categories. Results showed different aesthetic, comprehension, structural and emotional characteristics promoted by each design style. Renaissance design style was perceived as more figurative, more relaxing, simpler, typical, familiar and easy to understand. In contrast, Contemporary design style was found more interesting, and most liked. On the other hand, no differences were observed in the assessment of both architectural design styles regarding their positive or negative valence and their aesthetic value. Findings from this study can be applied for improving engineering and product design practice, and design education.