Miracle-dz/UniFAR-FTUs huggingface dataset:
The Usefulness of Preoperative Screening for Bleeding Disorders

P ediatricians often perform preoperative evaluations on their patients. In addition to a detailed history and physical examination, prothrombin time (PT) and activated partial thromboplastin (aPTT) are often performed to identify patients at increased risk for perioperative bleeding. However, there has been controversy about the need for such testing and its value in decreasing the risk of perioperative bleeding. Studies in the otolaryngology literature have shown that there is no significant increase in the risk of post-tonsillectomy bleeding in patients with abnormal coagulation studies compared to those with normal studies.1-3 However, some studies have shown that an abnormal preoperative coagulation profile may identify those patients at increased risk for perioperative bleeding.4-6 While most of these studies have used perioperative bleeding as the endpoint to assess the usefulness of preoperative screening, only a few have performed detailed coagulopathy evaluations to define the bleeding disorder.4,7 To determine if preoperative screening is useful in identifying a bleeding disorder, we retrospectively reviewed the coagulopathy evaluations of 131 children referred for a prolonged preoperative aPTT.
Sibylle : système linguistique d'aide à la communication pour les personnes handicapées

Ce memoire presente un systeme d'aide a la communication pour personne handicapee (parole et facultes motrices reduites). Sur ordinateur, un moyen de communication alternatif est la saisie de message sur clavier simule. Ce moyen de communication pose cependant un probleme d'excessive lenteur. Dans Sibylle, nous proposons deux aides complementaires. La premiere est une prediction de lettre qui permet de selectionner rapidement les lettres sur le clavier simule, en reclassant, apres chaque saisie, les lettres sur le clavier simule. Le classement est etabli en fonction des probabilites d'apparition des lettres estimees avec un modele n-gramme. La deuxieme aide est une prediction de mot dont le role est d'economiser les saisies. Pour etablir ces predictions, le modele de langage propose integre des connaissances d'ordre syntaxique (analyse en chunks aux modeles de langage stochastiques). Ces travaux ont donne lieu a une application, Sibylle, utilisee par des IMC au CMRRF de Kerpape.
Influence of Media and Testing Methodology on Susceptibility to Tigecycline of Enterobacteriaceae with Reported High Tigecycline MIC

ABSTRACT The tigecycline susceptibility of six different Enterobacteriaceae strains with reported high tigecycline MICs was determined in quintuplicate by four methodologies using Mueller-Hinton agar and broth from six manufacturers. The MICs determined by Etest were a ≥1-fold dilution lower than those determined by broth microdilution and agar dilution, with the highest modal values given by agar dilution. The highest modal MICs were obtained using Oxoid medium, and the lowest inhibition zone values (disc diffusion) were obtained using Oxoid and bioMérieux media. The lowest MICs were obtained by Etest using Difco or Merck media.
Excellent outcome of stage II neuroblastoma is independent of residual disease and radiation therapy.

The optimal management for patients with stage II neuroblastoma has not yet been established. In order to determine the impact of adding chemotherapy and/or radiation therapy to surgery, we reviewed by questionnaire 156 patients with stage II neuroblastoma treated by 28 Childrens Cancer Study Group (CCSG) institutions from 1978 to 1985. Survival and progression-free survival (PFS) were analyzed by life-table methods with respect to age at diagnosis, site and size of primary tumor, spinal cord involvement, extent of initial resection, and treatment in addition to surgery. The overall 5-year survival was 96%; the PFS was 90%, similar to previous CCSG studies. Age at diagnosis had a small impact on PFS, with 92% PFS for patients less than 2 years of age at diagnosis, and 84% for those greater than 2 (P = .10). The only site with an adverse outcome was the head and neck (n = 11), with a PFS of 68% compared with 93% for the remaining sites (P = .02). Size of primary and intraspinal extension of primary did not affect PFS. The extent of resection and subsequent treatment with radiation therapy and/or chemotherapy did not affect the PFS. The outcome for 75 patients treated with surgery alone (6-year PFS, 89%) was not significantly different from that of 66 patients receiving radiation therapy (6-year PFS, 94%). There was no significant difference between 40 patients with gross or microscopic residual disease treated with surgery alone (PFS, 92%) and 59 patients with residual disease who also received radiation (PFS, 90%). Five of seven patients who progressed after surgery alone have been salvaged with further therapy and are now free of disease. One survives with disease, so that the 6-year survival is 98% for those treated initially with surgery alone, compared with 95% for those receiving radiation therapy and/or chemotherapy. These data suggest that surgery alone, even if complete resection is not achieved, is sufficient initial therapy for stage II neuroblastoma. The data also identify another stage of neuroblastoma, in addition to stage IV-S, for which almost all patients have a favorable prognosis because their tumor may be biologically limited in growth.
Firm Size, Age, Leverage and Growth Opportunities: An initial inquiry by Pakistan

It is desired by all organizations to grow and sustain the factors of growth opportunities. This study is carried out to measure significant factors towards firm growth opportunities by using the data of Pakistani Firms. There were dissimilar results found in literature about selected variables with firm growth opportunities. This study is an attempt to support literature about significant factors towards growth opportunities by using the data of second largest Pakistan Industry (Sugar Sector). Pakistan Stock Exchange (PSX) listed firms have been observed as representative of overall sugar industry for the period of 1999-2015. Growth opportunities was observed with firm size, age, leverage, firm assets, industry sales, cash flows and market share by developing multiple linear regression model. It is found that growth opportunities for PSX listed firms are independent of its size, age and industry sales and all other explanatory variables are positively related with growth opportunities. This study supports literature that PSX listed firms show statistically significant and theoretically same results for all selected variables except firm size, age and industry sales.
Domain Adaptation for Sentiment Classification in Light of Multiple Sources

Sentiment classification is one of the most extensively studied problems in sentiment analysis, and supervised learning methods, which require labeled data for training, have been proven quite effective. However, supervised methods assume that the training domain and the testing domain share the same distribution; otherwise, accuracy drops dramatically. Although this does not pose problems when training data are readily available, in some circumstances, labeled data is quite expensive to acquire. For instance, if we want to detect sentiment from Tweets or Facebook comments, the only way to acquire is to manually label it, and this is prohibitively burdensome and time-consuming. In this paper, we propose a hybrid approach that integrates the sentiment information from source-domain labeled data and a set of preselected sentiment words to solve this problem. The experimental results suggest that our method statistically outperforms the state of the art and even, in some cases, surpasses the in-domain gold s.
Advanced mouse-tracking analytic techniques for enhancing psychological science

Computer mouse-tracking is a relatively recently developed behavioral methodology that can contribute unique insight into a wide variety of psychological phenomena. By recording mouse movements en route to specific responses on a screen, researchers glean continuous information about tentative commitments to multiple response alternatives over time. This approach yields a richness of data that can be fully explored with a variety of sophisticated analytic techniques, but these approaches are relatively underutilized and can be difficult to adopt. Here we describe several techniques for researchers to examine the onset and timing of evolving decision processes; test the degree of response competition at different time points; assess trajectory complexity with spatial disorder analyses; identify qualitatively distinct psychological processes during response generation; and finally to distill unique and meaningful components from mouse-tracking data for subsequent analysis. With this guide, we hope researchers can address novel hypotheses otherwise inaccessible with more traditional methods.
Acid Shock Accumulation of Sigma S in Salmonella enterica Involves Increased Translation, Not Regulated Degradation

Enteric pathogens such as Salmonella enterica and Escherichia coli face the daunting task of surviving passage through the extremely acid pH of the stomach in order to establish an infection in the host intestinal tract. These organisms have evolved elaborate stress response systems that aid in survival. The alternative sigma factor σS is a key regulator of many stress responses in S. enterica and is regulated at the levels of transcription, translation, and protein stability. Of these control mechanisms, proteolysis has been considered paramount in determining σS levels in the cell. Until the current report, acid shock was thought to increase σS levels by directly regulating degradation. However, mutant strains unable to degrade σS still exhibited acid shock induction of σS. We demonstrate here that rpoS translation is a major focus of acid stress control and is responsible for the observed increase in σS levels. A series of deletions of the 566-nucleotide untranslated region of the rpoS mRNA were constructed to examine the importance of this regulatory region in acid shock induction of rpoS. Progressive deletions starting from the 5′ end of the rpoS message produced alternating loss and recovery of acid shock control. The results suggest that competing stem-loop structures work in concert to control the acid shock induction of rpoS. Further, the half-life of σS was unchanged in response to acid shock and over-expression of the MviA recognition protein resulted in constitutive σS degradation under acid stress conditions. The data indicate that in log phase, nonstressed cells increasing σS production is sufficient to increase protein half-life. In toto, these results suggest that acid shock stabilization of σS is the result of increased synthesis via translational control and does not involve changes in the activity of the MviA (RssB/SprE) ClpXP degradation complex. Therefore, constitutive degradation may enable the cell to reset the level of σS once acid stress is alleviated.
Structure of the 1,4-bis(2'-deoxyadenosin-N6-yl)-2R,3R-butanediol cross-link arising from alkylation of the human N-ras codon 61 by butadiene diepoxide.

The solution structure of the 1,4-bis(2'-deoxyadenosin-N(6)-yl)-2R,3R-butanediol cross-link arising from N(6)-dA alkylation of nearest-neighbor adenines by butadiene diepoxide (BDO(2)) was determined in the oligodeoxynucleotide 5'-d(CGGACXYGAAG)-3'. 5'-d(CTTCTTGTCCG)-3'. This oligodeoxynucleotide contained codon 61 (underlined) of the human N-ras protooncogene. The cross-link was accommodated in the major groove of duplex DNA. At the 5'-side of the cross-link there was a break in Watson-Crick base pairing at base pair X(6). T(17), whereas at the 3'-side of the cross-link at base pair Y(7). T(16), base pairing was intact. Molecular dynamics calculations carried out using a simulated annealing protocol, and restrained by a combination of 338 interproton distance restraints obtained from (1)H NOESY data and 151 torsion angle restraints obtained from (1)H and (31)P COSY data, yielded ensembles of structures with good convergence. Helicoidal analysis indicated an increase in base pair opening at base pair X(6). T(17), accompanied by a shift in the phosphodiester backbone torsion angle beta P5'-O5'-C5'-C4' at nucleotide X(6). The rMD calculations predicted that the DNA helix was not significantly bent by the presence of the four-carbon cross-link. This was corroborated by gel mobility assays of multimers containing nonhydroxylated four-carbon N(6),N(6)-dA cross-links, which did not predict DNA bending. The rMD calculations suggested the presence of hydrogen bonding between the hydroxyl group located on the beta-carbon of the four-carbon cross-link and T(17) O(4), which perhaps stabilized the base pair opening at X(6). T(17) and protected the T(17) imino proton from solvent exchange. The opening of base pair X(6). T(17) altered base stacking patterns at the cross-link site and induced slight unwinding of the DNA duplex. The structural data are interpreted in terms of biochemical data suggesting that this cross-link is bypassed by a variety of DNA polymerases, yet is significantly mutagenic [Kanuri, M. , Nechev, L. V. , Tamura, P. J., Harris, C. M. , Harris, T. M. , and Lloyd, R. S. (2002) Chem. Res. Toxicol. 15, 1572-1580].
Sextus was no Eudaimonist

Ancient Greek philosophical schools are said to share a common structure in their ethical theories which is characterized by a eudaimonistic teleology based in an understanding of human nature. At first glance, the skepticism of Sextus Empiricus as described in the Outlines of Pyrrhonism seems to fit into this model insofar as he describes the end of the skeptic as ataraxia, a common account of the expression of human happiness. I argue that this is a misunderstanding of Sextus’s philosophy for several reasons. “The end of skepticism” cannot be eudaimonistic or teleological in the way that other ancient ethical theories are typically understood; moreover, ataraxia is not an end derived from a theory about human nature. For these reasons, the skeptical way of life is radically different than the ethical theories proposed by other schools. I argue that this difference is a result of the character of the skeptical enterprise which involves the implicit rejection of norms in both the epistemological and the ethical spheres. INDEX WORDS: Sextus Empiricus, Eudaimonism, Eudaimonia, Ancient ethics, Hellenistic ethics, Pyrrhonism, Ancient skepticism, Normativity SEXTUS WAS NO EUDAIMONIST
Urokinase plasminogen activator receptor promotes macrophage infiltration into the vascular wall of ApoE deficient mice

The urokinase plasminogen activator receptor (uPAR) regulates macrophage adhesion and migration by binding directly to matrix proteins and signaling through integrin complexes. In this study, we examined the role of uPAR on macrophage infiltration into the vascular wall. Stable murine macrophage (Raw264.7) cell lines expressing high levels of human uPAR, human urokinase plasminogen activator (uPA), or both were established using expression vectors driven by the human CD68 promoter. Stimulation with human uPA specifically induced phosphorylation of early response regulated kinase (ERK) in cells expressing human uPAR but not in sham transfected cells. The human uPAR expressing Raw264.7 cells showed increased adhesion to both human uPA and vitronectin (Vn). Raw264.7 cells expressing human uPAR or both human uPAR and uPA, but not uPA alone, were detected in the aortic wall of ApoE−/− mice, and no cells were detected in that of age‐matched C57BL/6J mice after intravenous infusion of the cells. Blocking of Mac‐1/ICAM‐1 interaction by anti‐αM antibody (M1/70) significantly reduced the infiltration of huPAR‐expressing Raw264.1 cells into aorta of ApoE−/− mice. Treatment of C57BL/6J mice with angiotensin II resulted in infiltration of Raw264.7 cells expressing human uPAR. These data demonstrate that uPAR plays a key role in promoting macrophage infiltration into the arterial wall of ApoE−/− mice. © 2004 Wiley‐Liss, Inc.
Comparison of Iodophor and Alcohol Pledgets with the Medi-Flex Blood Culture Prep Kit II for Preventing Contamination of Blood Cultures

ABSTRACT Iodophor and alcohol pledgets were compared with the Medi-Flex Prep Kit II for skin disinfection before venipuncture. Of 12,367 blood cultures collected, 6,362 were done with conventional pledgets and 6,005 were done with Medi-Flex kits. Contamination occurred in 351 of 6,362 blood cultures (5.5%; range, 3.7 to 8.1%) with conventional pledgets versus 328 of 6,005 (5.5%; range, 3.5 to 7.5%) with Medi-Flex kits.
Directors & Corporate Social Responsibility: Joint Consideration of Director Gender and the Director’s Role

ABSTRACT We examined the relationship between Corporate Social Responsibility (CSR) and director characteristics, including director gender and director role. Directors can have different roles on the board: executive directors (who are also managers of the company) and non-executive directors. Non-executive directors may be independent directors or grey directors (who are not executives but who have a relationship with the company or its executives that could compromise their independence). Female directors have been found in previous studies to be associated with CSR. We consider whether female directors are associated with CSR regardless of their director role, or whether females in different director roles may be more strongly associated with CSR. Using 4,194 firm-year observations from 2013 to 2015, we found that boards with more female directors have more CSR strengths and fewer CSR concerns. When examining the different roles assumed by female directors, we found that female independent directors are most strongly associated with CSR. Female executive directors were not associated the CSR and we had mixed results regarding female grey directors. Our results suggest the female director/CSR relationship depends upon both the gender of the director and the board role played by the director.
Ultrastructure of the corpus luteum of the cycling mare.

Corpora lutea of 12 cycling pony mares were studied by electron microscopy on Days 3, 9 and 15 after ovulation. In the early part of the secretory phase (Day 3), luteal cells were fully luteinized and contained numerous lipid droplets, round to elongate mitochondria with tubular cristae, perinuclear Golgi elements, dense bodies, multivesicular bodies and regions of extensively developed smooth endoplasmic reticulum (SER). On Day 9, luteal cells contained few lipid droplets, round to pleomorphic mitochondria with tubular cristae, dispersed Golgi elements, increased numbers of dense bodies, rare multivesicular bodies and an increased complement of SER. Decreased numbers of lipid droplets and hypertrophy of the SER correlated with known peak progesterone levels associated with Day 9. By Day 15, luteal cells displayed symptoms of degeneration including rarefied and swollen mitochondria, condensed whorls of SER, vesiculated SER, irregular or pycnotic nuclei, accumulations of pale lipid droplets, myelin figures and autophagic vacuoles. j3-glycogen particles were interspersed between SER cisternae in all time periods studied. Rarefied mitochondria were observed in otherwise nondegenerate cells and since mitochondrial enzymes catalyze the rate limiting step in progesterone synthesis, it is suggested that mitochondrial disruption may be an efficient way to terminate luteal progesterone synthesis.
Pulmonary Involvement in Patients with Guillain–Barré Syndrome in Subacute Phase

ABSTRACT Objectives: To evaluate the pulmonary function in Guillain�Barre syndrome (GBS) patients in subacute phase and find clinical correlates of pulmonary dysfunction. Methods: This was a single-center, prospective, cross-sectional, hospital-based study in GBS patients performed in Department of Neurological Rehabilitation at a tertiary care institute. Clinical examination for pulmonary function was done by measuring chest expansion. The pulmonary function tests were carried out by Spirometry kit Microquark Cosmed, Italy. Fatigue was assessed by Fatigue Severity Scale, disability status by Hughes Disability Scale (HDS), and muscle weakness by Medical Research Council sum scores. Statistical Analysis: Statistical analysis was performed by Stata 11. The significance of P value was adjudged against an alpha of 0.05. Results: Twenty-eight patients were included with 17 (61%) men and mean age of 31 years. Median duration of symptoms was 16.5 days. There were 10 (36%) demyelinating and 18 (64%) axonal variants. Twenty-six (93%) patients scored more than 2 on HDS. All study participants reported fatigue. Twenty-two (78.6%) patients had chest expansion of <2.5 cm. Spirometry showed restrictive pulmonary dysfunction in 23 (79%) patients. Significant correlation was found between abnormal pulmonary function test and chest expansion (P = 0.003). Conclusion: Pulmonary dysfunction in GBS is common even during subacute phase. It needs to be identified and managed appropriately for better clinical outcome.
Agency Cost Terhadap Kebijakan Dividen Pada Perusahaan Manufaktur Dan Jasa Yang Go Public Di Indonesia

This analysis developed to reach empirical evidence of the effect of agency costfactors toward evidence policy. In another hand this analysis wished to prove whether theagency problem able to be decreased through dividend payment mechanism withinmanufactures and services company in BEI, Indonesia, in 2000-2005. Agency cost variable hasbeing represented by Insider Ownership, Shareholder dispersion, Collateral Assets, debt andFree Cash Flow. The model which ran in this analysis was Multiple Linier Regressions. Theresult of analysis showed that agency problem able to be decreased through dividend paymentmechanism, from Insider Ownership which gives negative effect, Shareholders Dispersion whichgives positive effect, and Debt which gives negative effect toward dividend policy, whilecollateral assets and free cash flow not significant affecting to dividend policy within agencyconflict. Agency cost variable significant affected the dividend policy within agency conflictsimultaneously, with the sum of the effect was 18%.
Non-territorial office with various zoning increases privacy

: Allen and Gerstberger (1973) reported that non-territorial offices improve privacy. In actuality, however, a view of the office layout after an experiment showed that the office used in the experiment was not just simply made into a non-territorial office, but had various zoning done such that zones could be selected according to circumstance. With that idea in mind, this study analyzes the impact of non-territorial offices on privacy as well as the effect of various zoning, based on data of 6,592 individuals obtained through internet surveys. Results of the analysis showed that 1) non-territorial offices themselves do not have a major impact on privacy (they neither improve nor worsen privacy); 2) rather, various zoning is what improves privacy; and 3) further, of note is that privacy dramatically worsens in non-territorial offices without any various zoning, and vastly improves where various zoning has been thoroughly implemented. These results give one solution for the disputes over non-territorial offices and privacy, and provide suggestions for a new type of office (activity-based working, or an activity-based office).