Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of the nm23 homologues nm23‐H4, nm23‐H6, and nm23‐H7 in human gastric and colon cancer

Eight members of the nm23‐gene family have been described. The involvement of nm23‐H1 and nm23‐H2 in tumour progression and metastasis, as well as in gene regulation and apoptosis, has been shown in numerous studies. Whether nm23‐H4, ‐H6, and ‐H7 play a role in tumours is, however, largely unknown. This study describes data on the expression of these three nm23 homologues in human colon and gastric cancer by real‐time RT‐PCR and immunohistochemistry. Increased expression of these genes, most strikingly nm23‐H4 and ‐H7, was observed in the majority of tumours analysed. No correlation with tumour stage according to the TNM classification was found. In contrast, by immunohistochemical analysis, nm23‐H4 and ‐H6 overexpression correlated with the intestinal tumour type in gastric cancer tissues, whereas no increased immunoreactivity for the three nm23 proteins was noted in the diffuse type tumour specimens. These findings indicate that nm23‐H6, and particularly nm23‐H4 and ‐H7, may be involved in the development of colon and gastric carcinoma, the latter possibly in a type‐specific manner. A contribution to tumour progression or metastasis could not, however, be proven. Elucidation of the specific mechanisms by which the nm23 homologues nm23‐H4, ‐H6, and ‐H7 are involved in tumour development requires further studies. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Differential Expression of E‐ and P‐Selectin in the Microvasculature of Sickle Cell Transgenic Mice

Objective: There is a growing body of evidence that endothelial cells assume an inflammatory phenotype in sickle cell disease. The authors determined whether (1) the expression of E‐ and P‐selectin differs between sickle cell transgenic (βS) mice and their wild‐type counterparts, and (2) blood platelets and/or neutrophils contribute to the altered selectin expression.
Loss-of-Function Mutations of ROOT HAIR DEFECTIVE3 Suppress Root Waving, Skewing, and Epidermal Cell File Rotation in Arabidopsis1

Wild-type Arabidopsis (Arabidopsis thaliana L. Heynh.) roots growing on a tilted surface of impenetrable hard-agar media adopt a wave-like pattern and tend to skew to the right of the gravity vector (when viewed from the back of the plate through the medium). Reversible root-tip rotation often accompanies the clockwise and counterclockwise curves that form each wave. These rotations are manifested by epidermal cell file rotation (CFR) along the root. Loss-of-function alleles of ROOT HAIR DEFECTIVE3 (RHD3), a gene previously implicated in the control of vesicle trafficking between the endoplasmic reticulum and the Golgi compartments, resulted in an almost complete suppression of epidermal CFR, root skewing, and waving on hard-agar surfaces. Several other root hair defective mutants (rhd2-1, rhd4-1, and rhd6-1) did not exhibit dramatic alterations in these root growth behaviors, suggesting that a generalized defect in root hair formation is not responsible for the surface-dependent phenotypes of rhd3. However, similar alterations in root growth behavior were observed in a variety of mutants characterized by defects in cell expansion (cob-1, cob-2, eto1-1, eto2-1, erh2-1, and erh3-1). The erh2-1 and rhd3-1 mutants differed from other anisotropic cell expansion mutants, though, by an inability to respond to low doses of the microtubule-binding drug propyzamide, which normally causes enhanced left-handed CFR and right skewing. We hypothesize that RHD3 may control epidermal CFR, root skewing, and waving on hard-agar surfaces by regulating the traffic of wall- or plasma membrane-associated determinants of anisotropic cell expansion.
Muscle Biopsy and the Clinical Course of Infantile Spinal Muscular Atrophy

Eight infants with severe early infantile spinal muscular atrophy diagnosed by clinical presentation and muscle biopsy were studied. The extent of alterations in muscle histology, histochemistry, and ultrastructure did not reflect the relative severity of the clinical presentation or the course of the illness. In seven biopsies, ultrastructural studies demonstrated empty sleeves of basal lamina projecting from the surface of small myofibers. We conclude that severe infantile spinal muscular atrophy often results in myofiber atrophy similar to that found in other motor neuron diseases, and it is not solely a hypotrophic process. Muscle biopsy findings are important because they help to establish the diagnosis, but they do not help predict the severity of disease among infants with this condition. (J Child Neurol 1991;6:324-328).
iC3b‐opsonized apoptotic cells mediate a distinct anti‐inflammatory response and transcriptional NF‐κB‐dependent blockade

In recent years, it has become apparent that the removal of apoptotic cells by macrophages and DC is not only noninflammatory, but also immune‐inhibitory, in most although not all circumstances. Complement may be involved in the uptake of apoptotic cells via direct binding of bridging factors in some physiological circumstances, by opsonization and engagement of the complement receptors. In the current study, we use a complement‐dependent system of apoptotic cell clearance by human‐derived macrophages and DC. Using a luciferase reporter gene and measuring immune response to non‐opsonic zymosan, we show that iC3b‐apoptotic cells induce NF‐κB inhibition in response to zymosan and LPS at the nuclear translocation, transcriptional and post‐transcriptional levels, leading to profound inhibition of proinflammatory cytokines. In addition, interaction with iC3b‐opsonized apoptotic cells is characterized by macrophage secretion of IL‐10 and lack of TGF‐β secretion. In conclusion, in cells with iC3b receptors, opsonized apoptotic cells mediate a distinct anti‐inflammatory response and transcriptional NF‐κB‐dependent blockage.
Preschool Children's Demand for Sugar Sweetened Beverages: Evidence from Stated-Preference Panel Data

Consumption of sugar sweetened beverages exhibits strong associations with weight gain, obesity, and dental caries, especially in young children. The aim of this paper is to examine the impact of price changes on children’s consumption of sugar-sweetened beverages. Using micro-level panel data obtained from a stated preference experiment, we specify a two-sided censoring semi-parametric demand system model with fixed effects. To overcome an estimation difficulty that is potentially a common issue to all applications studying microlevel consumption data, we propose a new consistent two-step estimation framework. The economic restrictions implied by consumption theory are imposed through a consistent and asymptotically efficient GMM estimator. Our results show that the uncompensated own-price elasticities for sugar-sweetened beverages range from -0.83 to -0.94, demonstrating inelastic but substantial price effects. The marginal effects of demand with respect to nutritional attributes of sugar-sweetened beverages are negligible overall, but are strongest for those in low-income households. High-income households are less responsive to price and not responsive at all to non-price attributes.
Burden and factors associated with highway work-zone crashes, on a section of the Karachi–Hala Road, Pakistan

Objective To assess the burden and factors associated with highway work-zone (HWZ) crashes. Design Historical cohort. Setting Section of the Karachi–Hala Road, Pakistan (196 km). Data Police-reported crashes and traffic statistics from January 2006 to December 2008. Analysis Crash and death risk between the HWZ and other zones for a 50 km section were compared. Crash locations were described for a further 146 km section on which factors associated with HWZ crashes were assessed. Results HWZ crashes accounted for 15.0% of traffic crashes (N=180) and 30.8% of road fatalities (N=91) on the 196 km section. Rates were higher in the HWZ than other zones for crashes (rate ratio (RR)=2.35, 95% CI=1.17 to 4.70) and deaths (RR=4.70, 95% CI=2.11 to 10.46). Opposite-direction crashes (adjusted OR (aOR)=10.65, 95% CI=3.22 to 35.25) and traffic crashes involving pedestrians (aOR=6.03, 95% CI=1.39 to 26.20) and on wet surfaces (aOR=7.26, 95% CI=4.15 to 48.89) were significantly associated with the HWZ. Conclusion These results support the introduction of prevention measures such as strict traffic enforcement, traffic separation, improving pedestrian visibility, and hazard signage at HWZs in Pakistan. The feasibility and effectiveness of these measures remains to be evaluated.
The safety of anti PD-1 therapeutics for the treatment of melanoma

ABSTRACT Introduction: The introduction of immunotherapies into clinical practice has substantially improved the prognosis of metastatic melanoma patients as well as patients suffering from other cancers. The two FDA-approved checkpoint inhibitors against PD-1 (nivolumab and pembrolizumab) have been shown to significantly improve patient survival while being less toxic than previous treatment options. Areas covered: The current scientific literature on safety and adverse events (AEs) related to anti-PD-1 therapies has been investigated with special attention to case reports and to the latest results announced at the major clinical cancer and melanoma meetings, including ASCO (American Society of Clinical Oncology), ESMO (European Society of medical Oncology) and EADO (European Association of Dermato-Oncology) annual meetings. Expert opinion: Even though anti-PD-1 therapies are better tolerated than conventional chemo- or other immune-therapies, they still induce a plethora of AEs. Given the mechanism of action, it is supposed that most if not all of them are immune related. Fortunately, the majority are mild and manageable. However, due to the increase in patients’ life expectancy, there is a substantial need to understand and prevent severe cutaneous, pulmonary, neurological and other AEs which have major impact on the quality of life. The safety profile after long term use of these medications is still unclear. In addition, non-steroid based immune interventions to control autoimmunity are still to be developed.
Does adoption of conservation farming practices result in increased crop revenue? Evidence from Zambia

ABSTRACT We determine the impacts of conservation farming (CF) practices on crop net revenue of smallholder farm households using nationally representative household and plot survey data in Zambia. We estimate a multinomial endogenous switching regression model of farm household’s choice of combinations of CF practices and their impacts on crop net revenue. Four primary results are found. First, several factors affect adoption of CF practices depending on the combinations in which they are adopted. Second, all CF practices significantly increase crop net revenue per hectare when practised either singly or jointly. Third, a joint adoption of crop residue retention and minimum soil disturbance yields the highest crop net revenue per hectare among all the possible combinations of CF practices. Thus a more comprehensive approach that focuses on joint adoption of all CF practices is not the best income yielding portfolio. Fourth, adoption of CF practices in combination generally results in more crop net revenue per hectare than adopting them in isolation. Therefore, results point towards the need for promotion of adoption of CF practices in combination while considering the influence from household, seed, plot level, agro-ecological, and miscellaneous factors to enable farmers in Zambia to realise most payoffs.
Analysis of the Effect of Return on Equity (Roe) and Debt to Equity Ratio (Der) On Stock Price on Cement Industry Listed In Indonesia Stock Exchange (Idx) In the Year of 2011-2015

The purpose of this research is to determine the effect simultaneously and partially variable of financial factors consisting of Return on Equity (ROE) and Debt to Equity Ratio (DER) on stock price. Population in this research is cement industry listed in Indonesia Stock Exchange totaling 3 cement companies. The method of data collection used is documentation method, while the method of analysis used is Ordinary Least Square (OLS) method with linear regression model facilitated by SPSS 23. The results shows that Return on Equity (ROE) has significant effect on the stock price, and Debt to Equity Ratio (DER) has effect but not significant on stock price. Through this research it is suggested that the investors in implementing the investment not only consider financial factor, but also pay attention to other factor that is not raised in this study, such as politic, economic and other in order to the investment decision can benefit the investors.
AXIOMATIZING SEMANTIC THEORIES OF TRUTH?

Abstract We discuss the interplay between the axiomatic and the semantic approach to truth. Often, semantic constructions have guided the development of axiomatic theories and certain axiomatic theories have been claimed to capture a semantic construction. We ask under which conditions an axiomatic theory captures a semantic construction. After discussing some potential criteria, we focus on the criterion of ℕ-categoricity and discuss its usefulness and limits.
Occult HBV infection in Morocco: from chronic hepatitis to hepatocellular carcinoma

Morocco is one of low to intermediate endemic areas for hepatitis B virus (HBV) infection, but no reports have been published on Occult HBV infection (OBI). To determine the prevalence of OBI and its clinical impact among patients with cryptogenic and HCV‐related chronic liver disease in Morocco.
Visual Speech Synthesis Using Dynamic Visemes, Contextual Features and DNNs

This paper examines methods to improve visual speech synthesis from a text input using a deep neural network (DNN). Two representations of the input text are considered, namely into phoneme sequences or dynamic viseme sequences. From these sequences, contextual features are extracted that include information at varying linguistic levels, from frame level down to the utterance level. These are extracted from a broad sliding window that captures context and produces features that are input into the DNN to estimate visual features. Experiments first compare the accuracy of these visual features against an HMM baseline method which establishes that both the phoneme and dynamic viseme systems perform better with best performance obtained by a combined phoneme-dynamic viseme system. An investigation into the features then reveals the importance of the frame level information which is able to avoid discontinuities in the visual feature sequence and produces a smooth and realistic output.
Presence of Aedes (Stegomyia) aegypti (Linnaeus, 1762) and its natural infection with dengue virus at unrecorded heights in Colombia.

INTRODUCTION Aedes aegypti is the main vector of urban yellow fever, dengue, chikungunya and Zika viruses. The biogeographical distribution of this species has expanded due to global warming, and socioeconomic and cultural factors. The changes in the altitudinal distribution patterns of this vector and its natural infection are priority fields of research to develop entomological, virological and public health surveillance strategies. OBJECTIVE To evaluate the presence of A. aegypti and its natural infection with dengue virus in altitudes above 1.800 meters above sea level in two peripheral municipalities of the Valle de Aburrá, Antioquia, Colombia. MATERIALS AND METHODS Twenty-one ovitraps were set in the municipalities of Bello and San Pedro de los Milagros, at altitudes ranging from 1.882 to 2.659 masl. Emerged adults caught in the ovitraps were tested by RT-PCR for dengue virus detection. RESULTS We collected 367 A. aegypti adults, seven of which were found as high as 2.302 masl in Tierradentro, Bello. We detected serotype 2 dengue infection in 12 A. aegypti specimens collected in the neighbourhood of París, in Bello, at 1.984 masl. CONCLUSION We recorded A. aegypti at 2.302 masl, so far the highest altitudinal record in Colombia for this vector. Furthermore, mosquitoes collected at 1.984 masl were positive for dengue virus. These findings are significant as they identify regions in Colombia at risk of potential autochthonous transmission of dengue and other arboviruses by A. aegypti.
A hybrid fem-based method for aligning prone and supine images for image guided breast surgery

In breast conserving surgery clinicians may benefit from information from preoperative images (e.g. high quality dynamic contrast enhanced magnetic resonant image obtained in the prone position), by registering them to the supine patient on the operating table in the theatre. Due to large deformation involved between prone and supine, either non-rigid intensity-based mage registration methods or biomechanical model based methods alone have limited success. In this paper, we proposed a hybrid finite element method (FEM) based image registration method by combining patient-specific biomechanical models with nonrigid intensity-based image registration methods. FEM-based biomechanical models were used to estimate the major deformation of breasts while non-rigid intensity based image registration methods were used to recover the difference between experimental acquisitions and FE predictions due to the simplifications and approximations of biomechanical models. The proposed method shows a good performance for image registration, demonstrated by the experimental example of prone and supine MR breast image registration.
Effect of U-74500A, A 21-Aminosteroid on Renal Ischemia-Reperfusion Injury in Rats

Renal ischemia-reperfusion injury constitutes the most common pathogenic factor for acute renal failure and is the main contributor to renal dysfunction in allograft recipients and revascularization surgeries. Many studies have demonstrated that reactive oxygen species play an important role in ischemic acute renal failure. The aim of the present study was to investigate the effects of the synthetic antioxidant U-74500A, a 21-aminosteroid in a rat model of renal ischemia-reperfusion injury. Renal ischemia-reperfusion was induced by clamping unilateral renal artery for 45 min followed by 24 h of reperfusion. Two doses of U-74500A (4.0 mg/kg, i.v.) were administered 45 min prior to renal artery occlusion and then 15 min prior to reperfusion. Tissue lipid peroxidation was measured as thiobarbituric acid reacting substances (TBARS) in kidney homogenates. Renal function was assessed by estimating serum creatinine, blood urea nitrogen (BUN), creatinine and urea clearance. Renal morphological alterations were assessed by histopathological examination of hematoxylin-eosin stained sections of the kidneys. Ischemia-reperfusion produced elevated levels of TBARS and deteriorated the renal function as assessed by increased serum creatinine, BUN and decreased creatinine and urea clearance as compared to sham operated rats. The ischemic kidneys of rats showed severe hyaline casts, epithelial swelling, proteinaceous debris, tubular necrosis, medullary congestion and hemorrhage. U-74500A markedly attenuated elevated levels of TBARS as well as morphological changes, but did not improve renal dysfunction in rats subjected to renal ischemia-reperfusion. These results clearly demonstrate the in vivo antioxidant effect of U-74500A, a 21-aminosteroid in attenuating renal ischemia-reperfusion injury.
PENERAPAN MODEL UTAUT2 UNTUK MENJELASKAN MINAT DAN PERILAKU PENGGUNAAN MOBILE BANKING DI KOTA DENPASAR

Mobile banking is a service provided by the bank to support various banking transactions in order to gain effectiveness and efficiency. Theresearch purpose is to explain the use intention and use behavior of mobile banking through the application of Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) model. The research took place in Denpasar. The sampling method used accidental sampling. Data were obtained through a survey method with questionnaire technique. Research data analysis used multiple linear regression. The results showed performance expectancyaffects use intention of mobile banking. Habit and use intention affect use behavior of mobile banking.
Cell adhesion and movement in relation to the developing limb pattern in normal and talpid mutant chick embryos.

Descriptive studies of the talpid 3 chick embryonic lethal mutant ( ta 3 / ta 3 ) have suggested that the multiple effects produced by this gene are of mesodermal origin, and that they arise from defective mesenchymal cell movement and condensation (Ede & Kelly, 1964 a , b ). It may be argued that condensation in vivo is comparable to cell reaggregation of dissociated cells in vitro , and that defects in the former are likely to be reflected in the latter. In this case it should be possible to obtain experimental verification of this effect of the gene at the cellular level, using the quantitative methods for assessing aggregation developed by Moscona (1961 a , b ) and Curtis & Greaves (1965). The experiments reported here show a clear genetic effect upon cell adhesion in the wing-bud mesenchyme of the talpid 3 mutant. The wing-bud was chosen because it was hoped to establish a connexion between the effect of the gene at the cellular level and its dramatic effect on limb morphogenesis.
Standardization, Calibration, and Control in Flow Cytometry

Because flow cytometers are designed to measure particle characteristics, particles are the most common materials used to calibrate, control, and standardize the instruments. Definitions are provided for common terms to alert the reader to critical distinctions in meaning. The unit presents extensive background on particle types and cautions and goes on to describe practical aspects of methods to standardize and calibrate instruments, in terms of optical alignment, fluorescence and light scatter resolution, and sensitivity. Finally, suggestions follow for analyzing particles used for calibration.
Chronic allograft nephropathy--clinical guidance for early detection and early intervention strategies.

Improvements in reducing acute rejection rates following kidney transplantation in the last decade have not been mirrored by improvements in long-term graft survival rates [1,2]. One of the major causes of late graft loss in renal transplant recipients is chronic allograft nephropathy (CAN) [3–5] (Figure 1). CAN is highly prevalent in renal transplant recipients, with moderate to severe CAN present in 24.7% of recipients at 1 year post-transplant and in 89.8% of recipients by 10 years post-transplant [6]. CAN is defined by the histopathological features of interstitial fibrosis and tubular atrophy, but can also be associated with subclinical rejection, transplant glomerulopathy [6–8] or transplant vasculopathy caused by smooth muscle cell proliferation [4,9]. Therefore, the term CAN is being employed quite widely to describe a clinical syndrome instead of defining the presence of interstitial fibrosis or tubular atrophy. In order to avoid misinterpretations of this term, at the most recent ‘Banff’ meeting, it was proposed that pathologists no longer use this term, and simply refer to interstitial fibrosis and tubular atrophy (IF/TA) [10]. The term ‘chronic rejection’ has also been suggested as a possible replacement for CAN. However, this implies the pathology has an immune aetiology. As a pathological change often precedes any deterioration in function, the alternative term ‘chronic allograft dysfunction’ also has limitations. The revised Banff classification now recognizes chronic antibody-mediated rejection, in addition to IF/TA, broadening the underlying pathological lesions and pathophysiology of patients with