Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolic risk factors in adolescent girls with type 1 diabetes

Abstract Background: The incidence of pediatric metabolic syndrome (MS) has progressively increased. The incidence of type 1 diabetes mellitus (T1DM) has also increased. Thus, some children and adolescents with T1DM exhibit MS parameters. The aim of the study was to evaluate the presence of MS parameters in female adolescents with T1DM based on their nutritional status. Methods: We evaluated 44 adolescents with T1DM (consecutive non-randomized sample) aged between 14 and 18 years, who were on intensive therapy with insulin. Patients were subdivided according to their body mass index (BMI). Variables evaluated include: age, age at diagnosis, weight, height, BMI, abdominal circumference, blood pressure, glycated hemoglobin (HbA1c), abdominal and pelvic ultrasound and lipoprotein profile. Gynecological history data were also collected. Results: Lipid profile changes were identified in 32% of overweight or obese girls and in 23% of those with an adequate weight. Hypertension (HT) was observed in 19% of overweight or obese girls and in 14% of those with a BMI≥85th percentile (Pc). The only statistically significant difference between the groups was the presence of abdominal adiposity. All other features, including the presence of dyslipidemia, HT, abdominal adiposity, non-alcoholic steatohepatitis (NASH) and polycystic ovarian syndrome (PCOS), were present in both groups. Conclusions: Although being overweight and/or obese aggravates the risk of cardiovascular disease, MS is already present in many young adolescents with T1DM of normal weight. It is necessary that MS risk factors are routinely evaluated in all diabetic adolescents, including those with an adequate BMI.
We Are Patriots: National Identity Discourse in the Tea Party Movement and an Echoing Press

We Are Patriots: National Identity Discourse in the Tea Party Movement and an Echoing Press Damon Timothy Di Cicco Chair of the Supervisory Committee: Professor David Domke Department of Communication This dissertation explored the communicative means through which a social movement might connect its identity and goals with the national identity. It focused on invocations of the nation by Tea Party activists and in news depictions of the movement. I analyzed (1) how individual Tea Party members thought about the movement, (2) how the discourse of the Tea Party was presented to the public via high-profile events, and (3) how news media depicted foundational Tea Party events. Methodologically, the project combined in-depth qualitative interviews, participant observations, and a quantitative content analysis. Taken together, the findings suggest that the discourse of the Tea Party was shot-through with a variety of nation-invoking messages that constructed the movement as being of, by, and for America and its people, and that such messages were also highlighted in journalistic coverage, sometimes displacing more critical styles. By studying this domain of political communication, I sought to understand a relatively unexplored phenomenon in the field of communication—the discourse of conservative protest— and to shed light on the ways that social movement discourse might be related to news content. The work presented here has implications for both public activism and the practice of journalism, and thus how future social movements might engage with news media.
The politics of environmental mediation

Put most simply, environmental mediation is a process in which representatives of environmental groups, business groups, and government agencies sit down together with a neutral mediator to negotiate a binding resolution to a particular environmental dispute.I Since its beginning in the mid-seventies, environmental mediation has been the subject of serious political disagreement. 2 Proponents argue that environmental mediation is often less costly and less time consuming than litigation. 3 In addition, they claim mediated agreements are impartial and just.4 It is assumed that the agreements are mutually beneficial to the parties. In part, this assumption is based on the fact that mediation, as opposed to arbitration, is seen as a purely voluntary process in which the mediator has no power to impose a settlement.5 The voluntary nature of the process is thought to ensure that no party is forced into accepting a disadvantageous agreement. Despite this reassuring view of mediation and despite a growing
Child Poverty and Inequality: New Perspectives

The 21st century starts with vast inequalities for children in terms of income, access to food, water, health, education, housing, or employment for their families. Half of the world’s children are below the poverty line of $2 a day and suffer from multiple deprivations and violations to basic human rights. More than 22,000 children die each day, and most of their deaths are preventable. This volume presents some of the critical acknowledged voices to move a necessary agenda forward. It explains multidimensional poverty measurements, describes current trends and presents policies to reduce poverty and inequality.
Assessing and Addressing Health Literacy

The ability to communicate effectively with patients who have low health literacy depends on our ability to recognize this problem and to create a patient-centered and shame-free healthcare environment. Because of the shame and embarrassment these patients experience, they often use their well-developed coping skills to mask their limited literacy. Although a number of reading- and comprehension-assessment tools are available, there is debate whether or not these tools should be used clinically. This article provides guidance in regard to establishing an environment that promotes health literacy, assessing health literacy levels, utilizing strategies to increase health literacy, evaluating the learning that has occurred, and incorporating health literacy concepts into the nursing curriculum.
Intra-annual wood formation of subtropical Chinese red pine shows better growth in dry season than wet season

China's subtropical forests play a vital role in sequestering global carbon; therefore, it is critical to conduct a precise investigation of intra-annual wood formation in these ecosystems to clarify the mechanisms behind this. Two field experiments were established in Chinese subtropical forests to monitor weekly the intra-annual xylem formation of Pinus massoniana Lamb. from January to December 2015, using the recently developed micro-sampling approach. The effects of climate on wood formation were also assessed using linear or mixed models. Results indicate that there is an inactive period that might be semi-dormancy in subtropical pine ecosystems in January compared with the complete dormancy in temperate and boreal ecosystems and the fully active or short-term dormancy in tropical ecosystems. The duration of xylem formation of Chinese red pine in subtropical China in 2015 was 4-6 months longer than temperate and boreal forests. Moreover, trees were found to grow better during the dry season than the wet season, indicating that the Chinese red pine ecosystem is more strongly regulated by net energy than by environmental factors. Our findings indicate that China's subtropical pine forests may benefit from the expected longer dry seasons, possibly leading to better forest growth and improved carbon sequestration under continued climate warming.
How do grammatical patterns emerge? The origins and development of the English proper noun modifier construction

This article studies the emergence of a grammatical pattern, the proper noun modifier construction shown in the Obama administration, an Edinburgh restaurant. The only dedicated historical corpus study, by Rosenbach (2007, 2010), is limited in terms of time depth and data included, and suggests that only proper noun modifiers denoting places such as Edinburgh are found in the early seventeenth century. Using corpus data that span the full history of English, we trace the construction back to two Old English precursors, genitival modifiers without inflectional marking, e.g. Jericho feldes ‘the fields of Jericho’, and compounds, e.g. Easter æfen ‘Easter eve’. We combine macro-level visualisations of distributions and qualitative micro-analyses to show how these source constructions developed into the present-day English construction. The development defies simplistic views on grammatical change, but illustrates that grammatical patterns develop out of multiple sources under the influence of a multiplicity of factors. New patterns only emerge gradually and exploit existing ambiguities in the language.
Fronto‐Parietal Subnetworks Flexibility Compensates For Cognitive Decline Due To Mental Fatigue

Fronto‐parietal subnetworks were revealed to compensate for cognitive decline due to mental fatigue by community structure analysis. Here, we investigate changes in topology of subnetworks of resting‐state fMRI networks due to mental fatigue induced by prolonged performance of a cognitively demanding task, and their associations with cognitive decline. As it is well established that brain networks have modular organization, community structure analyses can provide valuable information about mesoscale network organization and serve as a bridge between standard fMRI approaches and brain connectomics that quantify the topology of whole brain networks. We developed inter‐ and intramodule network metrics to quantify topological characteristics of subnetworks, based on our hypothesis that mental fatigue would impact on functional relationships of subnetworks. Functional networks were constructed with wavelet correlation and a data‐driven thresholding scheme based on orthogonal minimum spanning trees, which allowed detection of communities with weak connections. A change from pre‐ to posttask runs was found for the intermodule density between the frontal and the temporal subnetworks. Seven inter‐ or intramodule network metrics, mostly at the frontal or the parietal subnetworks, showed significant predictive power of individual cognitive decline, while the network metrics for the whole network were less effective in the predictions. Our results suggest that the control‐type fronto‐parietal networks have a flexible topological architecture to compensate for declining cognitive ability due to mental fatigue. This community structure analysis provides valuable insight into connectivity dynamics under different cognitive states including mental fatigue.
Enhancing Backchannel Prediction Using Word Embeddings

Backchannel responses like “uh-huh”, “yeah”, “right” are used by the listener in a social dialog as a way to provide feedback to the speaker. In the context of human-computer interaction, these responses can be used by an artiﬁcial agent to build rapport in conversations with users. In the past, multiple approaches have been proposed to detect backchannel cues and to predict the most natural timing to place those backchannel utterances. Most of these are based on manually optimized ﬁxed rules, which may fail to generalize. Many systems rely on the location and duration of pauses and pitch slopes of speciﬁc lengths. In the past, we proposed an approach by training artiﬁcial neural networks on acoustic features such as pitch and power and also attempted to add word embeddings via word2vec. In this work, we reﬁned this approach by evaluating different methods to add timed word embeddings via word2vec. Comparing the performance using various feature combinations, we could show that adding linguistic features improves the performance over a prediction system that only uses acoustic features.
Genetic heterogeneity and actionable mutations in HER2-positive primary breast cancers and their brain metastases

Brain metastases constitute a challenge in the management of patients with HER2-positive breast cancer treated with anti-HER2 systemic therapies. Here we sought to define the repertoire of mutations private to or enriched for in HER2-positive brain metastases. Massively parallel sequencing targeting all exons of 254 genes frequently mutated in breast cancers and/or related to DNA repair was used to characterize the spatial and temporal heterogeneity of HER2-positive breast cancers and their brain metastases in six patients. Data were analyzed with state-of-the-art bioinformatics algorithms and selected mutations were validated with orthogonal methods. Spatial and temporal inter-lesion genetic heterogeneity was observed in the HER2-positive brain metastases from an index patient subjected to a rapid autopsy. Genetic alterations restricted to the brain metastases included mutations in cancer genes FGFR2, PIK3CA and ATR, homozygous deletion in CDKN2A and amplification in KRAS. Shifts in clonal composition and the acquisition of additional mutations in the progression from primary HER2-positive breast cancer to brain metastases following anti-HER2 therapy were investigated in additional five patients. Likely pathogenic mutations private to or enriched in the brain lesions affected cancer and clinically actionable genes, including ATR, BRAF, FGFR2, MAP2K4, PIK3CA, RAF1 and TP53. Changes in clonal composition and the acquisition of additional mutations in brain metastases may affect potentially actionable genes in HER2-positive breast cancers. Our observations have potential clinical implications, given that treatment decisions for patients with brain metastatic disease are still mainly based on biomarkers assessed in the primary tumor.
Campylobacteriosis in dogs and cats: a review

Abstract Campylobacter species are commonly isolated from faecal samples collected from dogs and cats, with the most prevalent species being C. upsaliensis, C. helveticus, and C. jejuni. Although the majority of dogs and cats are subclinically infected, some will develop mild to moderate enteritis. Immature animals, animals from intensive housing backgrounds, and animals with concurrent disease are especially predisposed to infection and the development of clinical signs. Bacterial culture methods applied in diagnostic laboratories remain biased to C. jejuni and C. coli detection, but molecular methods to diagnose Campylobacter spp. infections in dogs and cats have become widely available and can aid rapid and accurate diagnosis. Multilocus sequence typing has also been developed for subtyping different strains and has been used in epidemiological investigations. In the majority of cases, clinical signs are self-limiting and antimicrobial treatment is not warranted. Campylobacter spp. isolated from dogs and cats have shown resistance to commonly used antimicrobials, so antimicrobial therapy should only be administered where this is justified. Contact with dogs and cats is a recognised risk factor for human campylobacteriosis, thus people living or working in close contact with cats and dogs should be made aware of the zoonotic organisms these animals can shed.
Curative effect of PCI and CABG on left main coronary artery lesions

Coronary atherosclerotic heart disease (CHD) is the most common type of cardiovascular disease with increased incidence and serious damage to human life and health. Left main coronary artery lesions lead to severe ischemic symptoms, including ventricular fibrillation, cardiac shock, cardiac arrest, and even death. At present, two kinds of intervention such as percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) could be used for treatment. Comparison of their effects is still under investigation. 462 cases of patients who were diagnosed as left main coronary artery disease and received blood reconstruction surgery in our hospital between Jan 2009 and Dec 2012 were retrospectively analyzed. 270 cases were treated by PCI combined drug-coated stents, and 192 cases received CABG therapy. Parsonnet score and Karnofsky score were compared. Target lesion revascularization rate, incidence of myocardial infarction, adverse cerebrovascular events (MACCE), mortality, and curative effect were evaluated. No statistical difference was observed in Parsonnet score (P > 0.05). Follow-up analysis found PCI group has higher rate of target lesion revascularization, incidence of angina pectoris, incidence of MACCE than CABG group, whereas lower Karnofsky score (P < 0.05). Myocardial infarction and fatality rate were similar between two groups. In conclusion, our study showed that PCI and CABG showed similar curative effect for the treatment of left main coronary artery lesions, while CABG presented better long-term curative effect.
Establishing a Surgical Procedure for Rhesus Epiretinal Scaffold Implantation with HiPSC-Derived Retinal Progenitors

Background To develop an effective surgical procedure for cellular scaffold epiretinal implantation in rhesus, facilitating subsequent epiretinal stem cell transplantation. Methods Retinal progenitors were seeded onto a poly(lactic-co-glycolic) acid (PLGA) scaffold. First, the cellular scaffolds were delivered by 18G catheter or retinal forceps into rabbit epiretinal space (n = 50). Then, the cell survival rate was evaluated by Cell Counting Kit-8 (CCK-8). Second, three methods of scaffold fixation, including adhesion after gas-liquid exchange (n = 1), tamponade by hydrogel (n = 1), and fixation by retinal tacks (n = 4), were performed in rhesus monkeys. After one month, fundus photography and SD-OCT were performed to assess the outcomes, and histological examination was performed to evaluate proliferation. Results The cell survival rate was significantly higher in the catheter group. Follow-up examination showed that retinal tack fixation was the only method to maintain the scaffolds attached to host retina for at least 3 weeks, which is the minimal time required for cell integration. Histological staining demonstrated slight glial fibrillary acidic protein (GFAP) accumulation in the retinal tack insertion area. Conclusions The established surgical procedure offers a new insight into research of epiretinal cell replacement therapy in rhesus eyes. The successful delivery and long-term fixation provide a prerequisite for cell migration and integration.
Electrochemically Triggered Co-Conformational Switching in a [2]catenane Comprising a Non-Symmetric Calix[6]arene Wheel and a Two-Station Oriented Macrocycle

Catenanes with desymmetrized ring components can undergo co-conformational rearrangements upon external stimulation and can form the basis for the development of molecular rotary motors. We describe the design, synthesis and properties of a [2]catenane consisting of a macrocycle—the ‘track’ ring—endowed with two distinct recognition sites (a bipyridinium and an ammonium) for a calix[6]arene—the ‘shuttle’ ring. By exploiting the ability of the calixarene to thread appropriate non-symmetric axles with directional selectivity, we assembled an oriented pseudorotaxane and converted it into the corresponding oriented catenane by intramolecular ring closing metathesis. Cyclic voltammetric experiments indicate that the calixarene wheel initially surrounds the bipyridinium site, moves away from it when it is reduced, and returns in the original position upon reoxidation. A comparison with appropriate model compounds shows that the presence of the ammonium station is necessary for the calixarene to leave the reduced bipyridinium site.
Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis.

Background Dysfunction of the gut microbiota is frequently reported as a manifestation of chronic diseases, and therefore presents as a modifiable risk factor in their development. Diet is a major regulator of the gut microbiota, and certain types of dietary fiber may modify bacterial numbers and metabolism, including short-chain fatty acid (SCFA) generation. Objective A systematic review and meta-analysis were undertaken to assess the effect of dietary fiber interventions on gut microbiota composition in healthy adults. Design A systematic search was conducted across MEDLINE, EMBASE, CENTRAL, and CINAHL for randomized controlled trials using culture and/or molecular microbiological techniques evaluating the effect of fiber intervention on gut microbiota composition in healthy adults. Meta-analyses via a random-effects model were performed on alpha diversity, prespecified bacterial abundances including Bifidobacterium and Lactobacillus spp. , and fecal SCFA concentrations comparing dietary fiber interventions with placebo/low-fiber comparators. Results A total of 64 studies involving 2099 participants were included. Dietary fiber intervention resulted in higher abundance of Bifidobacterium spp. (standardized mean difference (SMD): 0.64; 95% CI: 0.42, 0.86; P < 0.00001) and Lactobacillus spp. (SMD: 0.22; 0.03, 0.41; P = 0.02) as well as fecal butyrate concentration (SMD: 0.24; 0.00, 0.47; P = 0.05) compared with placebo/low-fiber comparators. Subgroup analysis revealed that fructans and galacto-oligosaccharides led to significantly greater abundance of both Bifidobacterium spp. and Lactobacillus spp. compared with comparators (P < 0.00001 and P = 0.002, respectively). No differences in effect were found between fiber intervention and comparators for α-diversity, abundances of other prespecified bacteria, or other SCFA concentrations. Conclusions Dietary fiber intervention, particularly involving fructans and galacto-oligosaccharides, leads to higher fecal abundance of Bifidobacterium and Lactobacillus spp. but does not affect α-diversity. Further research is required to better understand the role of individual fiber types on the growth of microbes and the overall gut microbial community. This review was registered at PROSPERO as CRD42016053101.
Neural Machine Translation for Bilingually Scarce Scenarios: a Deep Multi-Task Learning Approach

Neural machine translation requires large amount of parallel training text to learn a reasonable quality translation model. This is particularly inconvenient for language pairs for which enough parallel text is not available. In this paper, we use monolingual linguistic resources in the source side to address this challenging problem based on a multi-task learning approach. More specifically, we scaffold the machine translation task on auxiliary tasks including semantic parsing, syntactic parsing, and named-entity recognition. This effectively injects semantic and/or syntactic knowledge into the translation model, which would otherwise require a large amount of training bitext to learn from. We empirically analyze and show the effectiveness of our multitask learning approach on three translation tasks: English-to-French, English-to-Farsi, and English-to-Vietnamese.
ELM triggering by local pellet perturbations in type-I ELMy H-mode plasma at JET

The pellet pacing ELM control concept developed at the mid-sized tokamak ASDEX Upgrade is considered for the larger machines JET and ITER as well. By driving up the ELM frequency, the ELM size can be reduced and eventually suppressed below a dangerous level. An according pellet injection system for JET is under construction; the ITER design includes one as well. However, it is still to be proven whether the concept will also work for bigger machine sizes. A step forward in this mission was achieved by re-analysing previous JET experiments dedicated to pellet particle fuelling. Although the experiments were performed in a parameter regime unsuitable for pellet ELM pacing both with respect to pellet frequency and size they demonstrate that prompt triggering of ELMs takes place at JET as well. Prompt triggering, an indispensable premise for useful pacing, obviously can be achieved already with a pellet size sufficiently small to avoid unbearable side-effects by particle fuelling. An ELM released by the local perturbation imposed by the ablating pellet in the plasma edge region is detected when only a minor fraction (less than 1%) of the fuelling size pellets (containing about 4 × 1021 D) was ablated and deposited. It is thus very likely that JET will allow for investigations on the operational technique and the underlying physics of pellet pacing once the new system becomes operational.