Miracle-dz/UniFAR-FTUs huggingface dataset:
Thyroid hormone affects the development of Sertoli cell function in the rat.

The relationship between thyroid activity and Sertoli cell function has been investigated in prepubertal rats. Male 28-day-old Wistar rats were used to prepare Sertoli cells by sequential enzyme digestion of the testes. Hypothyroidism, induced by oral administration of methimazole from the day of birth, was characterized by a severe retardation of body and testis growth and a net inhibition of the increase in Sertoli cell gamma-glutamyl transpeptidase (GGT) activity as well as in androgen-binding protein (ABP) and lactate production, which normally occur during postnatal development of Sertoli cells. The functional parameters of Sertoli cells from hypothyroid 28-day-old rats approximated to those of cells from euthyroid 15-day-old animals. These results are consistent with the impairment of protein synthesis in Sertoli cells from hypothyroid rats compared with controls. Body and testis growth were improved and Sertoli cell functions were restored with 3,3',5-tri-iodothyronine (T3) replacement therapy. An excess of T3 in the serum, induced by daily i.p. injections of T3 (100 micrograms/kg body wt) during the last week before the rats were killed, failed to induce changes in body and testis growth or in the activity of GGT and lactate dehydrogenase of Sertoli cells. Cells from hyperthyroid rats exhibited a specific decrease in ABP production. These results indicate that thyroid hormone is necessary for the postnatal maturation of Sertoli cell function and suggest a regulatory role of the hormone on gametogenic development in the prepubertal rat.
PERIODICITY OF DNA SYNTHETIC ENZYMES DURING THE HeLa CELL CYCLE

The levels of the deoxynucleoside phosphokinases have been determined during the cell cycle in synchronous cultures of HeLa cells. Deoxycytidine and thymidine phosphokinases showed temporally similar periodic fluctuations while the purine deoxynucleoside phosphokinases showed a constant high activity. Experiments with metabolic inhibitors suggest that the observed rise in thymidine phosphokinase activity is directly due to the enzyme's biosynthesis.
Quantitative and qualitative methods in medical education research: AMEE Guide No 90: Part I

Abstract Medical educators need to understand and conduct medical education research in order to make informed decisions based on the best evidence, rather than rely on their own hunches. The purpose of this Guide is to provide medical educators, especially those who are new to medical education research, with a basic understanding of how quantitative and qualitative methods contribute to the medical education evidence base through their different inquiry approaches and also how to select the most appropriate inquiry approach to answer their research questions.
A utilization management intervention to reduce unnecessary testing in the coronary care unit.

BACKGROUND There have been no studies of interventions to reduce test utilization in the coronary care unit. OBJECTIVE To determine whether a 3-part intervention in a coronary care unit could decrease utilization without affecting clinical outcomes. METHODS Practice guidelines for routine laboratory and chest radiographic testing were developed by a multidisciplinary team, using evidence-based recommendations when possible and expert opinion otherwise. These guidelines were incorporated into the computer admission orders for the coronary care unit at a large teaching hospital, and educational efforts were targeted at the house staff and nurses. Utilization during the 3-month intervention period was compared with utilization during the same 3 months in the prior year. The hospital's medical intensive care unit, which did not receive the specific intervention, provided control data. RESULTS During the intervention period, there were significant reductions in utilization of all chemistry tests (from 7% to 40%). Reductions in ordering of complete blood counts, arterial blood gas tests, and chest radiographs were not statistically significant. After controlling for trends in the control intensive care unit, however, the reductions in arterial blood gas tests (P =.04) and chest radiographs (P<.001) became significant. The reductions in potassium, glucose, calcium, magnesium, and phosphorus testing, but not other chemistries, remained significant. The estimated reduction in expenditures for "routine" blood tests and chest radiographs was 17% (P<.001). There were no significant changes in length of stay, readmission to intensive care, hospital mortality, or ventilator days. CONCLUSION The utilization management intervention was associated with significant reductions in test ordering without a measurable change in clinical outcomes.
Controlling intrinsic-shear alignment in three-point weak lensing statistics

Three-point weak lensing statistics provide cosmic information that complements two-point statistics. However, both statistics suffer from intrinsic-shear alignment, which is one of their limiting systematics. The nulling technique is a model-independent method developed to eliminate intrinsic-shear alignment at the two-point level. In this paper we demonstrate that the nulling technique can also be naturally generalized to the three-point level, thereby controlling the corresponding GGI systematics. We show that under the assumption of exact redshift information the intrinsic-shear alignment contamination can be completely eliminated. To show how well the nulling technique performs on data with limited redshift information, we apply the nulling technique to three-point weak lensing statistics from a fictitious survey analogous to a typical future deep imaging survey, in which the threepoint intrinsic-shear alignment systematics is generated from a power-law toy model. Using 10 redshift bins, the nulling technique leads to a factor of 10 suppression of the GGI/GGG ratio and reduces the bias on cosmological parameters to less than the original statistical error. More detailed redshift information allowing for finer redshift bins leads to better bias reduction performance. The information loss during the nulling procedure doubles the statistical error on cosmological parameters. A comparison of the nulling technique with an unconditioned compression of the data suggests that part of the information loss can be retained by considering higher order nulling weights during the nulling procedure. A combined analysis of two- and three-point statistics confirms that the information contained in them is of comparable size and is complementary, both before and after nulling.
In vitro activities of eight macrolide antibiotics and RP-59500 (quinupristin-dalfopristin) against viridans group streptococci isolated from blood of neutropenic cancer patients

From January 1988 to December 1994, 66 consecutive blood culture isolates of viridans group streptococci collected from febrile neutropenic cancer patients were tested for antimicrobial susceptibilities by the agar dilution method. The antibiotics studied were erythromycin, clarithromycin, roxithromycin, dirithromycin, azithromycin, josamycin, diacetyl-midecamycin, spiramycin, and quinupristin-dalfopristin. A total of 26 (39.4%) strains were resistant to erythromycin with an MIC range of 0.5 to > 128 micrograms/ml. The strains were classified into three groups according to their penicillin susceptibility: 42 (63.6%) were susceptible, 8 (12.1%) were intermediately resistant, and 16 (24.3%) were highly resistant. The percentages of erythromycin-resistant strains in each group were 23.8, 62.5, and 68.8%, respectively. Streptococcus mitis was the species most frequently isolated (83.3%) and showed the highest rates of penicillin (40%) and erythromycin (43.6%) resistance. MICs of all macrolide antibiotics tested and of quinupristin-dalfopristin were higher for penicillin-resistant strains than for penicillin-susceptible strains. All macrolide antibiotics tested had cross-resistance to erythromycin, which was not observed with quinupristin-dalfopristin. Our study shows a high rate of macrolide resistance among viridans group streptococci isolated from blood samples of neutropenic cancer patients, especially those infected with penicillin-resistant strains. These findings make macrolides unsuitable prophylactic agents against viridans group streptococcal bacteremia in this patient population.
Tissue expansion 1984–1999: A 15-year review

We assessed all patients who underwent tissue expansion, excluding breast reconstructions, between 1984 and 1999. A total of 237 patients had 257 expansions, normally for distorted scars, 202 of 257 cases (79%). Their mean age was 27 (range 7–67) years, most being women, 149 of 237 (63%). The mean duration of expansion was 16 weeks (range 0.4–118). The most common site was the skull (61/257). Prophylactic antibiotics were used in 224 of 257 (86%) at the time of expander insertion and 147 of 257 (56%) at the removal of the expander. Sixty-two patients (24%) had minor complications and 34 (13%) had major complications. Tissue expansion can be used with a currently acceptable failure rate though we continue to strive to lower this further.
The Effect of Online Reviews on Physician Demand : A Structural Model of Patient Choice

Introduction. Consumers in the healthcare market typically face uncertainty regarding the doctor’s quality, and may rely on imperfect signals to infer quality measures such as accuracy of diagnosis, bedside manner, and operational factors such as service time, waiting time, and appointment availability. By enabling large-scale distribution of information from countless other consumers, those consumer review websites can help resolve information asymmetries among a much broader peer group than has been traditionally possible. This paper provides empirical evidence on the impact of patient-generated reviews on demand in the outpatient healthcare market. We integrate and extend the advances in online marketing and healthcare operations literature, taking a step toward a more detailed understanding of patients’ choice behavior in the healthcare online markets and how it can help doctors improve the demand of outpatient care through operational strategies. The key challenges of this paper are to integrate the various sources of social media (both textual and numeric information), and leverage the aggregated level demand data into a consumer choice model. With the rapid growth and popularity of user-generated content (UGC) on the web, a new area of research has emerged that applies text mining techniques to product reviews. We have seen more and more papers in the information systems and marketing literature incorporate text information into the consumer choice models; however, limited research has looked at mining professional service reviews with operational factors and choice models in mind, and limited research in empirical operations management has utilized the information from text mining. One potential difficulty in mining doctor service reviews is deriving the operations based service features, namely, waiting time and service time. Compared to product reviews, the features for doctor service reviews have a more diverse format, due to service intangibility. Our goal here is to fill this gap by proposing a patient choice model that allows for doctors to be differentiated along multiple dimensions, contains richer distributions of taste parameters, and incorporates operational factors derived from online user-generated information.
Optimal cut-off values and population means of waist circumference in different populations

Abdominal obesity is a risk factor for cardiometabolic disease, and has become a major public health problem in the world. Waist circumference is generally used as a simple surrogate marker to define abdominal obesity for population screening. An increasing number of publications solely rely on the method that maximises sensitivity and specificity to define ‘optimal’ cut-off values. It is well documented that the optimal cut-off values of waist circumference vary across different ethnicities. However, it is not clear if the variation in cut-off values is a true biological phenomenon or an artifact of the method for identifying optimal cut-off points. The objective of the present review was to assess the relationship between optimal cut-offs and population waist circumference levels. Among sixty-one research papers, optimal cut-off values ranged from 65·5 to 101·2 cm for women and 72·5 to 103·0 cm for men. Reported optimal cut-off values were highly correlated with population means (correlation coefficient: 0·91 for men and 0·93 for women). Such a strong association was independent of waist circumference measurement techniques or the health outcomes (dyslipidaemia, hypertension or hyperglycaemia), and existed in some homogeneous populations such as the Chinese and Japanese. Our findings raised some concerns about applying the sensitivity and specificity approach to determine cut-off values. Further research is needed to understand whether the differences among populations in waist circumference were genetically or environmentally determined, and to understand whether using region-specific cut-off points can identify individuals with the same absolute risk levels of metabolic and cardiovascular outcomes among different populations.
Production efficiency of Jasmine rice producers in Northern and North-eastern Thailand

The paper jointly evaluates the determinants of switching to Jasmine rice and its productivity while allowing for production inefficiency at the level of individual producers. Model diagnostics reveal that serious selection bias exists, justifying use of a sample selection framework in stochastic frontier models. Results from the probit variety selection equation reveal that gross return (mainly powered by significantly higher Jasmine rice price), access to irrigation and education are the important determinants of choosing Jasmine rice. Results from the stochastic production frontier reveal that land, irrigation and fertilisers are the significant determinants of Jasmine rice productivity. Significantly lower productivity in Phitsanulok and Tung Gula Rong Hai provinces demonstrate the influence of biophysical and environmental factors on productivity performance. The mean level of technical efficiency is estimated at 0.63 suggesting that 59% [(100 - 63)/63] of the productivity is lost due to technical inefficiency. Policy implications include measures to keep Jasmine rice price high, increase access to irrigation and fertiliser availability, as well as investment in education targeted to farm households which will synergistically increase adoption of Jasmine rice as well as farm productivity. Copyright (c) 2009 The Authors. Journal compilation (c) 2009 The Agricultural Economics Society.
Impact of quality scales on levels of evidence inferred from a systematic review of exercise therapy and low back pain.

OBJECTIVE To assess whether the scale used affects levels of evidence inferred from a systematic review of studies on exercise therapy and chronic low back pain (LBP). DESIGN Twenty trials previously analyzed in a systematic review were assessed by 2 readers using 16 different scales. SETTING Tertiary care teaching hospital in France. PARTICIPANTS Chronic LBP patients. INTERVENTIONS Not applicable. MAIN OUTCOME MEASURE For the scales allowing classification into high- and low-quality trials, a rating system with 4 levels of evidence was used to summarize conclusions drawn. The Spearman rank correlation coefficient was used to assess correlations between the scores obtained with the different scales. Interrater reliability of the scales was assessed with the intraclass correlation coefficient and the Bland and Altman method, and the degree of agreement between the readers was calculated using the kappa coefficient. RESULTS Two of the 3 main results of the systematic review (conflicting evidence on the effectiveness of exercise therapy compared with inactive treatments; strong evidence that exercise therapy is more effective than usual care by a general practitioner) were influenced by the scale used. The range of the Spearman rank correlation coefficients between the different scales was wide (range,.49-.94), the interreader reliability of the scales was heterogeneous, and the interreader agreement was often low (kappa<or=.60 for 7/10 tests). CONCLUSIONS The use of summary scores to identify physical therapy trials of high quality is questionable. Different quality assessment scales should probably be used to assess pharmacologic interventions and physical therapies. Development and validation of quality scales specific to physical treatments are needed.
Methylphenidate Side Effects in Advanced Cancer: A Retrospective Analysis

Introduction: Methylphenidate (MP) is often recommended for symptom control in advanced cancer. Little is known about its side effects in frail adults. Objectives: To evaluate MP-associated symptoms or side effects (S/E). Methods: Data was collected from 2 published prospective cohort series and a phase 2 study of MP for symptom control in advanced cancer. All 3 reports had identical dosing schedules and symptom assessments. Initial MP doses were 10 mg/d (5 mg at 8 AM and at 12 noon) titrated up to a maximum of 30 mg/d. Depression, fatigue, and symptoms identified as possible MP S/E were evaluated for presence (prevalence) and for severity (using categorical scales) before MP (day 0) and on days 3, 5, and 7 thereafter. The categorical scale used was none, mild, moderate, and severe. Results: 62 patients were enrolled. Fifty completed 7 days of MP with a median age of 69 (range 30-90) years. Thirty-five received MP 10 mg/day. Most (96%) had improvement in depression and/or fatigue. Among the 62 patients, new symptom prevalence throughout the study was agitation (16%), insomnia (16%), dry mouth (15%), nausea (10%), tremors (6%), anorexia (5%), headache (3%), palpitations (2%), and vomiting (2%). Patients could have more than 1 symptom simultaneously. Seven (11%) withdrew due to MP S/E. Some symptoms present before MP showed significant improvement during MP therapy. Conclusions: (1) Treatment with MP (10-20 mg/d) in advanced cancer is well tolerated. (2) S/E symptoms with MP appeared to improve spontaneously despite continued MP therapy. (3) Depression and fatigue improved at doses lower than those recommended in other clinical conditions. (4) MP improved depression and fatigue, and some secondary symptoms associated with them. Methylphenidate (MP) appears safe when used in the treatment of depression and fatigue in advanced cancer.
Mode of perfusion influences infarct size, coronary flow and stress kinases in the isolated mouse heart

The isolated, retrogradely perfused heart (modified Langendorff model) is a widely used method in experimental heart research. The presence of an intraventricular balloon is necessary to get functional measurements. We have previously shown that the balloon induces phosphorylation of some suggested cardioprotective mitogen‐activated protein kinases (MAPK): P38‐MAPK, ERK 1/2 and JNK. We hypothesized that the balloon could influence cardioprotection, protect against ischaemia reperfusion injury and interfere with coronary flow.
Rhythmic Arm Cycling Induces Short-term Plasticity of Soleus H-reflex Amplitude by

Plasticity in spinal networks has been proposed as a means to permit motor skill learning and recovery after central nervous system disorders. This plasticity is significantly driven by input from the periphery (Wolpaw & Carp, 2006). For instance, attenuation of soleus Hoffmann (H) reflex can last beyond the period of different types of conditioning via putative presynaptic inhibition (Brooke et al., 1997). Interestingly, rhythmic arm cycling can also attenuate soleus H-reflex via interlimb connections and presynaptic pathways (Frigon, Collins, & Zehr, 2004). However, it remains to be studied if this attenuation is maintained beyond the period of arm cycling. In this study, we hypothesized that excitability of H-reflex pathway would remain suppressed after cessation of arm cycling. Subjects were seated with their trunk and feet fixed at a neutral position. Using an arm ergometer, they cycled at 1Hz for 30min. H-reflexes were evoked via stimulation of the tibial nerve in the popliteal fossa at 5 minute intervals. These intervals began prior to the cycling and continued during cycling and up to 30 minutes
Does Physical Exercise Influence the Frequency of Postmenopausal Hot Flushes?

The frequency of moderate and severe hot flushes was investigated in a group of women (n=142) who took part in organized physical exercise on a regular basis, and a control group of all women 52 and 54 years old in the city of Linkoping, Sweden (n = 1,246). Only women with natural menopause and without a history of hormonal replacement treatment were statistically compared in the study. It appeared that moderate and severe vegetative symptoms with hot flushes and sweatings were only half as common among the physically active postmenopausal women (21.5%) as in the control group (43.8%). Although this could be due to a positive selection of these physically active women, it might also be due to the fact that exercise may affect the mechanisms that elicit hot flushes in peri‐ and postmenopausal women.
Acoustic and perceptual analysis of speech adaptation to an artificial palate

The study investigated adaptation to a standard electropalatographic (EPG) practise palate in a group of eight adults (mean age = 24 years). The participants read the phrase “a CVC” over four sampling conditions: prior to inserting the palate, immediately following insertion of the palate, 45 minutes after palate insertion, and 3 hours after insertion of the palate. Perceptual and acoustic analyses were conducted on the initial CV portion of the stimuli. Consonants examined included: /t/, /k/, /s/, and /∫/ followed by the /i/, /a/, and /u/ vowels. Results revealed that individuals within the group were able to adapt their speech articulation to compensate for the presence of the artificial palate. Perceptually, mild consonant imprecision was observed upon insertion of the palate; however, this resolved following 45 minutes to 3 hours of adaptation. Acoustic findings indicated that the palate did not affect segment durations or vowel formant frequencies. However, a significant reduction in M1 for /s/ persisted across the sampling periods. Overall, the results suggest that a period of between 45 minutes and 3 hours of adaptation is generally suitable for participation in EPG studies.
Health and Economic Growth

The strong observable correlation between health and economic growth is crucial for economic development and sustained well-being, but the underlying causality and mechanisms are difficult to conceptualize. Three issues are of central concern. First, assessing and disentangling causality between health and economic growth are empirically challenging. Second, the relation between health and economic growth changes over the process of economic development. In less developed countries, poor health often reduces labor force participation, particularly among women, and deters investments in education such that fertility stays high and the economy remains trapped in a stagnation equilibrium. By contrast, in more developed countries, health investments primarily lead to rising longevity, which may not significantly affect labor force participation and workforce productivity. Third, different dimensions of health (mortality vs. morbidity, children’s and women’s health, and health at older ages) relate to different economic effects. By changing the duration and riskiness of the life course, mortality affects individual investment choices, whereas morbidity relates more directly to work productivity and education. Children’s health affects their education and has long-lasting implications for labor force participation and productivity later in life. Women’s health is associated with substantial intergenerational spillover effects and influences women’s empowerment and fertility decisions. Finally, health at older ages has implications for retirement and care.