Miracle-dz/UniFAR-FTUs huggingface dataset:
Drivers and obstacles on the way to the one million dollar business opportunity: The interplay of human capital and intra-team trust in entrepreneurial team opportunity recognition and selection

The present dissertation examines how intra-team trust in entrepreneurial teams affects the influence of prior experience on opportunity recognition performance. The empirical results of an experimental study with 75 entrepreneurial teams in Germany show that intra-team trust is a hindering condition for the relationship between prior experience and the opportunity recognition performance. Taken together, the present dissertation contributes most to the literature on entrepreneurial teams.
An unusual phenotype of X‐linked developmental delay and extreme behavioral difficulties associated with a mutation in the EBP gene

We report on a family in which four males over three generations are affected with X‐linked recessive developmental delay, learning difficulties, severe behavioral difficulties and mild dysmorphic features. Plasma sterol analysis in three of the four affected males demonstrated increased concentrations of 8‐dehydrocholesterol (8‐DHC) and cholest‐8(9)‐enol. All four affected males had a novel hemizygous missense mutation, p.W47R (c.139T>C), in EBP. Functional studies showed raised levels of cholest‐8(9)‐enol in patient's cultured fibroblast cells, which were suppressed when the cells were incubated with simvastatin. EBP encodes 3β‐hydroxysteroid‐delta8, delta7‐isomerase, a key enzyme involved in the cholesterol biosynthesis pathway. Mutations in EBP have previously been associated with Conradi–Hunermann–Happle syndrome (CHH), an X‐linked dominant disorder characterized by skeletal dysplasia, skin, and ocular abnormalities, which is usually lethal in males. Four previous reports describe X‐linked recessive multiple anomaly syndromes associated with non‐mosaic EBP mutations in males, two at the same amino acid position, p.W47C. This phenotype has previously been described as “MEND” syndrome (male EBP disorder with neurological defects). The family reported herein represent either a novel phenotype, or an expansion of the MEND phenotype, characterized by extreme behavioral difficulties and a scarcity of structural anomalies. Simvastatin therapy is being evaluated in two males from this family. © 2014 Wiley Periodicals, Inc.
Optical absorption in semiconductor quantum dots: A tight-binding approach.

We present a tight-binding calculation of the interband optical transitions in semiconductor quantum dots (QD's). The calculated optical-absorption spectra are in good agreement with the existing experimental spectra of CdS and CdSe QD's. We establish a correspondence between the tight-binding (TB) energy levels and those calculated using the spherical multiband effective-mass approximation (EMA). Consequently, the comparatively stringent selection rules of the latter are applicable to a large extent. Thus rue formulate a convenient and quantitatively accurate description of the optical absorption in QD's in terms of the TB energy levels and multiband EMA quantum numbers
Phenotypic Suppression of the Gibberellin-Insensitive Mutant (gai) of Arabidopsis

The semidominant gibberellin-insensitive (gai) mutant of Arabidopsis thaliana shows impairment in multiple responses to the plant hormone gibberellin A3, which include effects on seed germination, stem elongation, apical dominance, and rapid flowering in short days. Results presented here show that the gai mutation also interferes with development of fertile flowers in continuous light. Mu-tagenesis of the gai mutant resulted in recovery of 17 independent mutants in which the gibberellin-insensitive phenotype is partially or completely suppressed. Sixteen of the suppressor mutations act semidominantly to restore gibberellin responsiveness. One representative of this class, the gar1 mutation, could not be genetically separated from the gai locus and is proposed to cause inactivation of the gai gene. The exceptional gar2 mutation partially suppresses the gai phenotype, is completely dominant, and is not linked to the gai locus. The gar2 mutation may define a new gene involved in gibberellin signaling. A recessive allele of the spindly (SPY) locus, spy-5, was also found to partially suppress the gai mutant phenotype.
Nucleotide Sequence of the SrRNA Gene and Phylogenetic Analysis of Trichomonas tenax

The small subunit ribosomal RNA (SrRNA) gene of Trichomonas tenax ATCC30207 was amplified by PCR and the 1.55‐kb product was cloned into plasmid vector pUC18. Four clones were isolated and sequenced. The insert DNAs were 1,552 bp long and their G+C contents were 48.1%; three of them had exactly the same DNA sequences and one had only one nucleotide change. A representative SrRNA sequence was analyzed and a phylogenetic tree was estimated by the neighbor‐joining (NJ) method. Among the protists examined, T. tenax was placed as the closest relative of Tritrichomonas foetus, as expected from the traditional taxonomy. The total homology between the two SrRNA sequences was 89.2%.
Renal Sympathetic Denervation for the Treatment of Systemic Hypertension

Systemic hypertension is a common cardiovascular problem that often cannot be fully treated with existing nonpharmacologic and pharmacologic measures. A catheter-based strategy which denervates the renal afferent and efferent autonomic nervous system has been developed for the treatment of drug-resistant hypertension. In early clinical trials, this procedure was shown to be both feasible and safe in reducing blood pressure in patients with uncontrolled hypertension receiving treatment with a minimum of 3 antihypertensive drugs. In addition, this procedure has been associated with decreased renin secretion, preservation of renal function, improved glucose tolerance, and a reduction in left ventricular hypertrophy. The long-term effects of this procedure (beyond 3 years) still need to be determined. A large 530-patient sham-controlled trial is now in progress.
Mineral content of calcium and magnesium in the serum and longitudinal periodontal progression in Japanese elderly smokers.

OBJECTIVE Evidence from physiological and clinical studies regarding the mechanism by which calcium and magnesium are associated with periodontal disease, adjusted for smoking habits, is lacking. This longitudinal study evaluated the association of serum calcium levels and the calcium/magnesium (Ca/Mg) ratio with periodontal disease progression among smokers and non-smokers. MATERIAL AND METHODS A total of 309 subjects aged 73 years were included. Follow-up surveys were carried out every year for 6 years. After dividing subjects into smokers and non-smokers, multiple logistic regression analysis for men was performed to evaluate the relationship between the serum Ca/Mg ratio and periodontal disease progression. We used the 25th percentile of periodontal disease events for 6 years as the dependent variable and seven other variables, including quartiles for serum Ca/Mg ratios, as independent variables. RESULTS There was a clear dose-response relationship of Ca/Mg ratio quartiles for periodontal disease events among smokers. Significant differences in odds ratios in the first and second quartiles were seen compared with the fourth quartile (reference): 6.28 (p=0.014) and 5.96 (p=0.022), respectively. However, there was no significant dose-response relationship among non-smokers. CONCLUSION A low serum Ca/Mg ratio was significantly associated with periodontal disease progression in Japanese elderly smokers.
Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

There is a limited understanding about the impact of rare protein truncating variants across multiple phenotypes. We explore the impact of this class of variants on 13 quantitative traits and 10 diseases using whole-exome sequencing data from 100,296 individuals. Protein truncating variants in genes intolerant to this class of mutations increased risk of autism, schizophrenia, bipolar disorder, intellectual disability, ADHD. In individuals without these disorders, there was an association with shorter height, lower education, increased hospitalization and reduced age. Gene sets implicated from GWAS did not show a significant protein truncating variants-burden beyond what captured by established Mendelian genes. In conclusion, we provide the most thorough investigation to date of the impact of rare deleterious coding variants on complex traits, suggesting widespread pleiotropic risk. Main abbreviations PTV = Protein Truncating Variants PI = Protein Truncating Intolerant PI-PTV = Protein Truncating Variant in genes that are Intolerant to Protein Truncating Variants
Application of the Willis Covered Stent in the Treatment of Aneurysm in the Cisternal Segment of the Internal Carotid Artery: A Pilot Comparative Study with Midterm Follow-up

Purpose: To compare the use of the Willis stent-graft versus coil embolization for complicated aneurysms in the cisternal segment of the internal carotid artery (ICA). Methods: Thirty-four patients (19 women; mean age 46.7±16.8 years, range 3–79) with 36 complicated aneurysms were treated either by Willis covered stents (n=19) or by coil embolization (n=17). Follow-up angiography was performed to investigate aneurysm recurrence, endoleak, and parent artery stenosis. Kaplan-Meier curves were constructed to compare the freedom from recurrence and parent artery stenosis rates in both groups. Clinical follow-up data were retrospectively analyzed and categorized as fully recovered, improved, unchanged, or worsened. Results: In the covered stent group, total exclusion was immediately achieved in 13 aneurysms; there were 5 minor endoleaks and 1 delivery failure. In the patients treated with coil embolization, total/near-total occlusion was achieved in 7 aneurysms, subtotal in 8, and partial in 2. Acute thrombosis occurred in 1 patient in each group, while 1 patient experienced recurrent hemorrhage after embolotherapy. Follow-up angiography (mean 14.3±9.4, range 3–31) revealed that 16 aneurysms were completely isolated in the stent-graft group, with only 2 mild in-stent stenoses. Eighteen months after the procedure, Kaplan-Meier analysis showed recurrence-free rates of 93.3% and 50% for the stent-graft versus coil groups, respectively; freedom from parent artery stenosis was 87.5% and 100%. Symptoms were fully eliminated in 9 patients in each group; they were improved in 3 and 5, unchanged in 2 and 2, and worsened in 1 and 0, respectively, at the end of the follow-up period. Conclusion: Willis stent-graft application is an alternative to treat complicated aneurysms in the cisternal segment of the ICA. In the case of a tortuous parent artery or potential side branch coverage, however, it is still not a first choice therapy.
The Impact of Top Management Team Diversity on Firm Performance: A Study of Large Companies in Malaysia

The current economic climate has changed the landscape of business dramatically in the perspective of global environment. Hence, in order to respond for the global changes in term of economic, social, politic and technology, organization should enhance the right mix of top management teams (TMT) for current and future progression and growth of the organization. Diversity of top management team plays an important role to determine the performance of the organization. This conceptual paper is to examine the impact of top management team diversity traits on firm performance. The study will adopt quantitative research design with secondary data, for the average of five years. Secondary data mainly involves financial data that will be obtained financial databases such as DATASTREAM based on 200 nonfinancial large companies in Malaysia. The multiple regression analysis and cross-sectional study will be used to test the hypothesis. Issues surrounding top management team’s diversity, upper echelon theories and the mixed findings from previous research are offered as potential avenues for empirical research. Therefore, the line of inquiries needs a fundamental work and empirical analysis using above methodology. The preliminary results leading toward for a better understanding of the factor that explains how top management diversity translates into greater organizational achievements and argues the need to analyse the characteristics of top management teams and their composition more extensively, especially in the context of large companies. This is a cross-sectional study, variables, concepts, constructs and hypotheses will be carefully constructed and developed to meet the objectives of the study. Multivariate analyses will be adopted, and in this regard, panel data analyses using the E- VIEW/STATA statistical software will be used to suit the requirement of considering both crosssectional and time series data in the analyses.
Pengaruh Due Professional Care, Time Budget Pressure, Etika Auditor Dan Fee AuditorTerhadap Kualitas Audit (Studi Empiris Pada Kantor Akuntan Publik Di Surakarta Dan Semarang)

Purpose of the research was to know effect of due ofessional care, timebudget pressure, auditor‘s ethics and auditor’s fee on quality of audit. Populationof the research was auditors working in Public Accountant Offices of Surakarta and Semarang.Sample was taken by using convenience sampling. Sample of the researchwas 54 respondents. Analysis data of the research used multiple regressionanalysis.Results of the research indicated that coefficient of determination of the multiple regression was adjusted R2 of 0.847. It means that 84.7% of variablevariances consisting of due professional care, time budget pressure, auditor‘sethics and auditor’s fee and the rest of 15.3% were explained by factors other thaninvestigated in the research. Results of t-testindicated that due professional careand time budget pressure had no significant effect on quality of audit, whereasauditor’s ethics and auditor’s fee had significant effect on the audit quality.
Data Warehouse Success Lead towards Supply Chain Efficiency

Data warehouse management is crucial challenge due to which most of the supply chain companies are facing the issues of data management. These challenges effect adversely on data warehouse success and ultimately effect negatively on supply chain efficiency. Different studies are carried out by different researchers on the area of supply chain, however, these studies are missing with the element of data warehouse management. Therefore, the objective of the study is to examine the factors that influence on data warehouse success and supply chain efficiency. Data were collected from warehouse employees working in Indonesian supply chain companies. Results of the study shows that data warehouse success is based on various factors such as system quality, information quality, service quality and relationship quality. These factors have positive association with data warehouse success and data warehouse success increases the supply chain efficiency. Thus, companies should focus on these elements to promote data warehouse success. This study is helpful for practitioners to promote supply chain efficiency through data warehouse success.
Desensitization of IP3‐induced Ca2+ release by overexpression of a constitutively active Gqα protein converts ventral to dorsal fate in Xenopus early embryos

The constitutively active Gqα mutant construct (GqαQ‐L) in Xenopus early embryos was overexpressed and the effects on dorsoventral patterning examined. It was found that prolonged stimulation of inositol 1,4,5‐trisphosphate (IP3)‐Ca2+ signaling by overexpression of GqαQ‐L led to desensitization of IP3‐induced Ca2+ release (IICR). Desensitization of IICR on the ventral side specifically induced an ectopic dorsal axis due to the conversion of ventral marginal mesoderm to adopt a dorsal fate. This effect of desensitization resembles that of inhibitory antibodies against the IP3 receptor, as reported previously. These results strengthen the earlier finding that active IP3‐Ca2+ signaling functions in ventral signaling during the early embryonic development of Xenopus. Furthermore, the nature of downregulation of the Xenopus IP3 receptor through continuous stimulation of IP3‐Ca2+ signaling might play a role in regulating endogenous IP3‐Ca2+ signaling in Xenopus early development.
Did investors feel fairer after Regulation Fair Disclosure? Evidence from abnormal trading volume before earnings announcements

This paper examines the impact of Regulation Fair Disclosure on the abnormal trading volume before earnings announcements. The authors show that after Regulation Fair Disclosure, the average abnormal trading volume over a period of eight days before earnings announcements is 4% lower than before. In addition, the paper shows that this lower abnormal trading volume is more pronounced in small firms and technology firms. The empirical results are consistent with Regulation Fair Disclosure inducing investors to perceive higher earnings-related information asymmetry before earnings announcements.
Microenvironment and Immunology T Lymphocytes Expressing a CD 16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing

To expand applications for T-cell–based immunotherapy in cancer, we designed a receptor that binds the Fc portion of human immunoglobulins and delivers activation signals. The construct included the high-affinity CD16 (FCGR3A) V158 variant, CD8a hinge, and transmembrane domains, alongwith signaling domains fromCD3z and 4-1BB (TNFRSF9), forming a chimeric receptor termed CD16V-BB-z. After retrovirus-mediated expression in human T cells, CD16V-BB-z bound humanized antibodies with higher affinity than a control receptor containing the more common F158 variant. Engagement of CD16V-BB-z provoked T-cell activation, exocytosis of lytic granules, and sustained proliferation, with amean cell recovery after 4-week coculturewithDaudi lymphoma cells and rituximab of nearly 70-fold relative to input cells. In contrast, unbound antibody alone produced no effect. CD16V-BB-z T cells specifically killed lymphoma cells and primary chronic lymphocytic leukemia cells in combinationwith rituximab at a low effector:target ratio, evenwhen assayed onmesenchymal cells. Trastuzumab triggered CD16V-BB-z–mediated killing of HER2 (ERBB2)þ breast and gastric cancer cells; similar results were obtainedwith an anti-GD2 antibody in neuroblastoma and osteosarcoma cells. Furthermore, coadministration of CD16V-BB-z T cells with immunotherapeutic antibodies exerted considerable antitumor activity in vivo. Signaling mediated by 4-1BB-CD3z induced higher T-cell activation, proliferation, and cytotoxicity than CD3z or FceRIg , and the receptor was expressed effectively after mRNA electroporation without viral vectors, facilitating clinical translation. Our results offer preclinical proof of concept for CD16V-BB-z as a universal, next-generation chimeric receptor with the potential to augment the efficacy of antibody therapies for cancer. Cancer Res; 74(1); 1–11. 2013 AACR.
Critical conditions for co-workershipin healthcare organizations: A workplace health promotion perspective

The workplace is well-established as one of the priority settings for promoting health in a large population. To achieve a good work environment, cooperation between managers and employees is essential. However, there is a large discrepancy between the amount of management and leadership research that has been performed and the amount of research investigating the impact of important factors of co-workership. Thus, the overall aim of this thesis was to increase knowledge about critical conditions for co-workership in healthcare organizations from the employee’s point of view. This thesis has also a practical aim of providing information that can be used and applied in establishing a holistic and sustainable health-promoting workplace. A qualitatively-driven mixed-methods approach was applied, combining different qualitative methods to gather and analyze data. Study I used data collected through observations, interviews, focus group interviews, and feedback seminars, analyzed with content analysis and descriptive statistics. Study II used data collected from twelve focus group interviews with 68 employees, analyzed with phenomenography. The results from Study I show that the communication flow and organization of the observed meetings varied in terms of physical setting, frequency, time allocated, and duration. The topics for the workplace meetings were mainly functional with a focus on clinical processes. Overall, the meetings were viewed not only as an opportunity to communicate information from the top downwards, but also as a means by which employees could influence decision-making and development at the workplace. The results from Study II show that the phenomenon of coworkership was experienced as a collective process, which included colleagues but not did explicitly include managers. Five categories emerged, representing different conceptions of co-workership: group coherence and striving toward a common goal, cooperation over professional and organizational boundaries, work experience and trusting each other’s competence, social climate and sense of community, and participation and influence. The conclusion of this thesis is that conditions such as participation and influence, social support, and communication were mostly related to the employees’ everyday work, especially the clinical work, and were not seen in relation to the overall organization. Workplace meetings seemed to be a well-functioning setting for conditions of importance for co-workership, although the outcomes of these meetings varied to a large extent. This knowledge provided in this thesis can be of importance for future strategies to develop health-promoting workplaces.
Operational Management of Enterprise Structures in the Sphere of Education and Science: Problems and Methods for their Solution

In the present article the author examines the practices and problems of information and communication technologies (including the Internet) to improve the organization and management of educational institutions of higher education and research institutions in the Russian Federation at the present stage of information-communication technologies implementation for optimization of scientific, educational and administrative processes. During the study, the author examines the functionality of various software and hardware complexes of Russian and foreign production. Attention is paid to software products from Microsoft and of Sun, however, without neglecting products, developed by the Russian software companies. During the study, the author draws attention to the specific features of the structure of the major educational institutions of higher education and scientific organizations in the Russian Federation. It is noted, that in view of significant geographical remoteness (and not only in one subject of the Russian Federation, but also a variety of subjects of Russian Federation, which are often located in different federal districts) of different structural units of the introduction of information and communication technologies can not only speed up the process, but also significantly save costs and increase control. In the conclusion the author presents five scientifically proven points.