Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma.

PURPOSE Bendamustine HCl is a bifunctional mechlorethamine derivative with clinical activity in the treatment of non-Hodgkin's lymphoma. This study evaluated bendamustine plus rituximab in 67 adults with relapsed, indolent B-cell or mantle cell lymphoma without documented resistance to prior rituximab. PATIENTS AND METHODS Patients received rituximab 375 mg/m(2) intravenously on day 1 and bendamustine 90 mg/m(2) intravenously on days 2 and 3 of each 28-day cycle for four to six cycles. An additional dose of rituximab was administered 1 week before the first cycle and 4 weeks after the last cycle. Sixty-six patients (median age, 60 years) received at least one dose of both drugs. RESULTS Overall response rate was 92% (41% complete response, 14% unconfirmed complete response, and 38% partial response). Median duration of response was 21 months (95% CI, 18 to 24 months). Median progression-free survival time was 23 months (95% CI, 20 to 26 months). Outcomes were similar for patients with indolent or mantle cell histologies. The combination was generally well tolerated; the primary toxicity was myelosuppression (grade 3 or 4 neutropenia, 36%; grade 3 or 4 thrombocytopenia, 9%). CONCLUSION Bendamustine plus rituximab is an active combination in patients with relapsed indolent and mantle cell lymphoma.
Oxidized lipids as mediators of coronary heart disease

Purpose of review To summarize the recent evidence on the physiological relevance of the view that LDL lipid oxidation may play a major role in the inflammatory reaction that leads to or amplifies atherogenesis. Oxidation of LDL phospholipids containing arachidonic acid at the sn-2 position occurs when a critical concentration of ‘seeding molecules’ derived from the lipoxygenase pathway is reached in LDL. This generates a series of biologically active, oxidized phospholipids that mediate the cellular events seen in the developing fatty streak. Recent findings We have observed that LDL from mice that are genetically predisposed to diet-induced atherosclerosis is highly proinflammatory when the mice are maintained on an atherogenic diet, when they are injected with LDL-derived oxidized phospholipids, or once they are infected with influenza A virus. Patients with coronary atherosclerosis also had highly proinflammatory LDL, despite having normal blood lipid levels or normal plasma HDL levels. Summary We and others have hypothesized that HDL and LDL-derived oxidized phospholipids may be part of a system of nonspecific innate immunity. We therefore propose that determination of HDL capacity against LDL oxidation and the detection of proinflammatory HDL may be a useful marker of susceptibility to atherosclerosis.
THE ART AND SCIENCE OF TEACHING ROUNDS: A Strategy for Staff Development

Teaching rounds can be a highly interactive, fluid process for developing staff nurses' critical thinking, assessment, and interpersonal skills. In this article, the authors describe how to conduct and evaluate teaching rounds using the example of Pain Management Teaching Rounds conducted by an advanced practice nurse on medical-surgical units of a large medical center. Qualitative and quantitative outcomes of the pain management rounds are discussed.
Academic Coach and Classroom Teacher: A Look inside a Rural School Collaborative Partnership.

This yearlong qualitative case study examines the successful collaborative partnership between a first year academic coach and a teacher in a rural school setting. The partnership became a source of interest as a means to understanding how rural school partnerships are developed and sustained. Data was collected through thirty-four site visits utilizing formal and informal interviews, observations, artifact collection, and detailed field notes. Characteristics that were associated with a successful rural school collaborative partnership include life experiences, personality, a willingness to change, empathy, trust and confidentiality, respect, and persistence. The partnership was also impacted by personal and professional needs, many of which were rural in context. The findings present a nuanced look inside a rural school collaborative partnership.
Financial Structure and Instability in an Open Economy

The subprime loan mortgage crisis has revived scholarly interest in Minsky fs financial instability hypothesis. The related mathematical models present two types of Minskian financial structures, which we identify as the lenders f risk type (LR) and the hedge, speculative and Ponzi type (HSP) We construct macrodynamic models in a fixed and floating exchange rate sys- tem which considers both the LR and HSP financial structures. We examine the effects of international capital mobility and international lenders f risks and demonstrate the significance of the LR and HSP financial structures in the fixed and floating exchange rate system. We emphasize the significance of stable financial structures in order to stabilize dynamic systems in an open economy.
Hepatitis B and C Virus Infection and Risk of Pancreatic Cancer: A Population-Based Cohort Study (JPHC Study Cohort II)

Background: The aim of this study was to assess the association between hepatitis B virus (HBV) and hepatitis C virus (HCV) and the risk of pancreatic cancer among Japanese adults. Methods: A total of 20,360 subjects of the Japan Public Health Center (JPHC)–based prospective study cohort II with available data on HBV and HCV infection status from blood samples were followed up until the end of 2010 for an average of 16 years. Cox proportional hazards models were employed to calculate HRs and 95% confidence intervals (CI). Results: During 324,394 person-years, 116 newly diagnosed cases of pancreatic cancer were identified. Compared with individuals without a positive infection marker, the multivariate-adjusted HRs were 1.22 (95% CI, 0.81–1.84) for anti-HBc and 0.69 (95% CI, 0.28–1.69) for anti-HCV. There were no pancreatic cancer cases among HBsAg-positive participants. Conclusion: In the JPHC study, we did not observe a statistically significant association between hepatitis B or C and the risk of pancreatic cancer. Impact: Our results do not support an association between hepatitis B or C and the risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev; 25(3); 555–7. ©2015 AACR.
Does corruption limit FDI and economic growth? Evidence from MENA countries

Purpose The purpose of this paper is to analyze the effects of corruption on investment and growth in 15 Middle East and North African (MENA) countries during the period 1985-2013. The authors used the International Country Risk Guide (ICRG) corruption index and conducted a panel cointegration analysis and Granger causality procedure to detect the dynamic relationships between the variables. Results indicate that corruption is a serious hurdle to economic growth in MENA countries since it affects investment activities and foreign direct investment inflows. In this case, policymakers have to implement effective anti-corruption strategies to avoid the epidemic of corruption. Design/methodology/approach The authors used the ICRG corruption index and conducted a panel cointegration analysis and Granger causality procedure to detect the dynamic relationships between the variables. Findings The main findings of this paper show that corruption is a serious hurdle to economic growth in MENA countries since it affects investment activities and foreign direct investment inflows. In this case, policymakers have to implement effective anti-corruption strategies to avoid the epidemic of corruption. Research limitations/implications Unfortunately, in this study the authors did not use institutional variables to see their role and to judge whether governments should enhance the quality of institution and improve the corporate governance. This would be an opportunity to expand the sample and to conduct a new research in the near future to assess the real costs of corruption in the MENA region. Practical implications Governments and policymakers need to apprehend and admit that corruption is an important issue that deters foreign direct investment and threats the economic development and growth. Corruption can also deteriorate the infrastructure and increase the cost of doing business for both government and private sector which in turn will lower the growth (Tanzi and Doovi, 1997). It is worth recalling that during the past five years, a large part of the MENA region has witnessed multiple social upheavals. Hence, corruption must be tackled effectively and coherently to avoid further social tensions. It is the proper time to take serious steps and strict policy actions within a zero-tolerance framework to fight corruption and its widespread. New rules, laws, and anti-corruption procedures are among the most important initiatives that governments should implement. The governments should also increase the public awareness of the multiple drawbacks of corruption by publishing official reports and data on the most corrupted sector in the country. In this case, media will have a key role to diffuse the necessary information. Originality/value While most of the previous studies have employed GMM and OLS techniques, the authors opt a panel vector error correction model and cointegration technique to detect causality between the variables used in the model for the present study.
Cell associations and surface features in cultures of juvenile rat seminiferous tubules

Short pieces of seminiferous tubules from juvenile rats were grown in tissue culture and studied by phase contrast light microscopy while living and by transmission and scanning electron microscopy after fixation and appropriate processing. The pieces of tubules remodeled in vitro, with the original explant becoming surrounded closely by a sheet of epithelioid cells and more peripherally by elongate cells. The epithelioid cells were identifiable as Sertoli cells because of the presence of characteristic Sertoli‐Sertoli cell junctions near their upper surface. The elongate cells were derived from peritubular tissues, but could not be specifically identified as to cell type. Clusters of stellate cells and of round cells were present on the upper surface of the Sertoli cell sheets, but not on the elongate cells or the bare floor of the culture dish. The stellate cells were spermatogonia and the round cells were spermatocytes, as identified by fine structural features. Intercellular bridges were maintained between germ cells in culture without being surrounded by processes of Sertoli cells. Rudimentary junctions were present between germ cells and Sertoli cells in culture. The shape of germ cells in vitro was the same as the shape in situ, indicating that shape is an inherent feature of germ cells and is not determined by surrounding Sertoli cells.
Assessing the Climate Effects of Biofuels Using Integrated Assessment Models, Part I: Methodological Considerations

Estimates of the climate‐change mitigation benefits of biofuels are varied and controversial. Some analysts rely on attributional life cycle assessment (ALCA), limiting the analytic scope to the direct supply chain, whereas others supplement an ALCA result with an estimate of land‐use change (LUC) emissions intensity. Other analysts have used consequential life cycle assessment (CLCA), with methods ranging from static market assessments to identify the likely marginal product and supplier, to running partial and general equilibrium models to estimate changes in global production and consumption. In this article, we consider another alternative—using an integrated assessment model (IAM) as a platform for CLCA of biofuels. In this article (part I of II), we focus on the methodological challenges of this approach. In part II, we present a case study using one IAM—the global change assessment model (GCAM)—to estimate the climate effects of several biofuels.
G-Protein-coupled Receptors and Fcγ-receptors Mediate Activation of Akt/Protein Kinase B in Human Phagocytes*

Activation of the serine/threonine kinase Akt, also called protein kinase B (PKB), was investigated in human neutrophils. Stimulation of the cells with the chemoattractant fMet-Leu-Phe or the chemokines IL-8 and GROα leads to the rapid and transient activation of PKB. Maximum PKB activation correlates with the well documented kinetics of respiratory burst and exocytosis. Wortmannin, a selective inhibitor of phosphoinositide 3-kinases (PI 3-kinases) in neutrophils, abrogates PKB activation. Similarly homo and heterotypic cross-linking of FcγIIA and FcγIIIB causes a transient activation of PKB that is sensitive to wortmannin treatment. Kinase activity measurements in immunoprecipitates from lysates of the myelocytic GM-1 cells or GM-1/CXCR1 cells, which are transfected with the IL-8 receptor 1, confirmed the transient activation of PKB observed in neutrophils. Stimulation of human monocytes with the CC chemokine RANTES (regulated on activation normal T cell expressed and secreted) also results in the activation of PKB. Preincubation of monocytes and neutrophils with Bordetella pertussis toxin inhibits fMet-Leu-Phe and RANTES-stimulated PKB activation, demonstrating that coupling of the receptors to heterotrimeric Gi-protein is required. The data show, that activation of PKB by Gi-protein-coupled receptors is mediated by PI 3-kinase and suggest that PKB is a constituent of neutrophil activating pathways.
Saccharomyces cerevisiae immobilized onto cross-linked chitosan beads: application of a novel material for the removal of dye toxicity

ABSTRACT Waste from textile industries can severely harm the environment. Dyes are the main residues of these effluents. Saccharomyces cerevisiae is already known to be an efficient adsorbent for the removal of dyes. However, the lack of applicability and limitation of the use of cell biomass in an industrial treatment makes it impossible to apply them. Thus the aim of this work was to immobilize S. cerevisiae in cross-linked chitosan beads by two different techniques (contact immobilization and encapsulation in the polymer matrix), proposing two new materials for adsorption. Adsorption experiments were carried out to analyse the kinetics, isotherm and thermodynamics adsorptive of the synthesized materials. The adsorption data obtained were compared with the S. cerevisiae biomass and with the cell-free cross-linked chitosan beads to evaluate the efficiency of the two synthesized materials. The Fourier transform infrared spectrophotometer was used to characterize and analyse the main adsorption sites of the tested materials. Bioassays using the microcrustacean Daphnia similis verified if the materials could reduce the toxicity of the medium after its application in the treatment. Both materials synthesized in this work can potentially remove dyes from effluents, in addition to being able to significantly decrease dye toxicity from an aqueous medium.
Nonfatal dog bite-related injuries treated in hospital emergency departments--United States, 2001.

In 1994, the most recent year for which published data are available, an estimated 4.7 million dog bites occurred in the United States, and approximately 799,700 persons required medical care. Of an estimated 333,700 patients treated for dog bites in emergency departments (EDs) in 1994, approximately 6,000 (1.8%) were hospitalized. To estimate the number of nonfatal dog bite-related injuries treated in U.S. hospital EDs, CDC analyzed data from the National Electronic Injury Surveillance System-All Injury Program (NEISS-AIP). This report summarizes the results of the analysis, which indicate that in 2001, an estimated 368,245 persons were treated in U.S. hospital EDs for nonfatal dog bite-related injuries. Injury rates were highest among children aged 5-9 years. To reduce the number of dog bite-related injuries, adults and children should be educated about bite prevention, and persons with canine pets should practice responsible pet ownership.
Etiology of childhood diarrhea in Korea

To assess the role of recently recognized enteropathogens in childhood diarrhea in Korea, 231 children with diarrhea admitted to and 104 children without diarrhea seen at the well-baby clinic or the outpatient department of Hanyang University Hospital in Seoul, Korea, were evaluated during a 14-month period. Stools were cultured for bacterial pathogens, including enterotoxigenic (heat-labile and heat-stable enterotoxin-producing) and enteroadherent organisms. Only those stools obtained from patients with diarrhea were examined for rotavirus. All Escherichia coli isolates were screened for Shiga-like toxin (SLT) I, SLT-II, enterohemorrhagic E. coli fimbriae, and enteroinvasiveness by colony hybridization. One or more pathogens were identified in 75.8% of the children with diarrhea. Rotavirus was the most frequently identified pathogen, accounting for 47% of the cases. Other major enteropathogens were enterotoxigenic E. coli (22%), Clostridium difficile (16%), enteroadherent E. coli (15%), and enteropathogenic E. coli (6%). Shigella spp. , Campylobacter jejuni, Salmonella spp. , SLT-I-and enterohemorrhagic-E. coli-fimbria-probe-positive E. coli serotype O26:H11 and enteroinvasive E. coli were isolated from only a few patients. Aeromonas hydrophila and E. coli O157 were not isolated. Compared with those of the controls, the isolation rates of heat-stable-enterotoxin-producing E. coli (P less than 0.05), C. difficile (P less than 0.025), and enteroadherent E. coli (P less than 0.05) were significantly higher in the patients with diarrhea. The greatest number of rotavirus, enterotoxigenic E. coli, and C. difficile cases were identified during the cool, dry months of October and November.
Skewed Business Cycles

This paper studies how the distribution of the growth rate of firm-level variables (sales, profit, inventories, and employment) changes over the business cycle. Using a panel of Compustat firms from 1964 to 2013 we find that, in addition to the well-documented counter cyclicality in dispersion, the third moment---skewness---is strongly pro cyclical. This happens because the distribution of negative growth rates expands during recessions while the distribution of positive growth rates changes little. In fact, this pattern---of lower tail greatly expanding during recessions---is also the main driver behind the counter cyclicality of dispersion. These results are robust to different selection criteria, across firm size categories, and across industries. We also analyze the distribution of macroeconomic outcomes such as GDP growth and stock returns using a panel of developed and developing countries. Here we also find evidence of declining skewness during periods of low economic activity.
Explaining Physicians' Acceptance and Resistance to the NHI Pharmacloud: A Theoretical Model and Empirical Test

The PharmaCloud allows physicians to streamline many of their healthcare processes and ensure patient safety in a more efficient and cost-effective manner. Despite its great potential, however, there are gaps in our understanding of how physicians evaluate change in relation to the PharmaCloud and why they decide to resist it. Thus, this study develops an integrated model to explain physicians’ intention to use the PharmaCloud and their intention to resist it. A field survey was conducted in Taiwan to collect data from physicians. Structural equation modeling (SEM) using the partial least squares (PLS) method was employed to test the research model. The results show that physicians’ resistance to the use of the PharmaCloud is the result of regret avoidance, inertia, perceived value, transition costs, and perceived threat. Information quality, system quality, and service quality are shown to have positive and direct effects on physicians’ intention to use the PharmaCloud. Our study illustrates the importance of incorporating user resistance in technology acceptance studies in general and health technology usage studies in particular, providing grounds for a model of resistance that can serve as the starting point for future research in this relatively unexplored yet potentially fertile area of research.
Recent progress in vaccination against human papillomavirus‐mediated cervical cancer

It has been more than 7 years since the commercial introduction of highly successful vaccines protecting against high‐risk human papillomavirus (HPV) subtypes and the development of cervical cancer. From an immune standpoint, the dependence of cervical cancer on viral infection has meant that HPV proteins can be targeted as strong tumour antigens leading to clearance of the infection and the subsequent protection from cancer. Commercially available vaccines consisting of the L1 capsid protein assembled as virus‐like particles (VLPs) induce neutralising antibodies that deny access of the virus to cervical epithelial cells. While greater than 90% efficacy has been demonstrated at the completion of large phase III trials in young women, vaccine developers are now addressing broader issues such as efficacy in boys, longevity of the protection and inducing cross‐reactive antibody for oncogenic, non‐vaccine HPV strains. For women with existing HPV infection, the prophylactic vaccines provide little protection, and consequently, the need for therapeutic vaccines will continue into the future. Therapeutic vaccines targeting HPVE6 and E7 proteins are actively being pursued with new adjuvants and delivery vectors, combined with an improved knowledge of the tumour microenvironment, showing great promise. This review will focus on recent progress in prophylactic and therapeutic vaccine development and implementation since the publication of end of study data from phase III clinical trials between 2010 and 2012. Copyright © 2015 John Wiley & Sons, Ltd.
Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis

The two‐dimensional membrane topology of the Escherichia coli and Staphylococcus aureus MraY transferases, which catalyse the formation of the first lipid intermediate of peptidoglycan synthesis, was established using the β‐lactamase fusion system. All 28 constructed mraY–blaM fusions produced hybrid proteins. Analysis of the ampicillin resistance of the strains with hybrids led to a common topological model possessing 10 transmembrane segments, five cytoplasmic domains and six periplasmic domains including the N‐ and C‐terminal ends. The agreement between the topologies of E. coli and S. aureus, their agreement to a fair extent with predicted models and a number of features arising from the comparative analysis of 25 orthologue sequences strongly suggested the validity of the model for all eubacterial MraYs. The primary structure of the 10 transmembrane segments diverged among orthologues, but they retained their hydrophobicity, number and size. The similarity of the sequences and distribution of the five cytoplasmic domains in both models, as well as their conservation among the MraY orthologues, clearly suggested their possible involvement in substrate recognition and in the catalytic process. Complementation tests showed that only fusions with untruncated mraY restored growth. It was noteworthy that S. aureus MraY was functional in E. coli. An increased MraY transferase activity was observed only with the untruncated hybrids from both organisms.