Miracle-dz/UniFAR-FTUs huggingface dataset:
The Breast Cancer Information Core: Database design, structure, and scope

The Breast Cancer Information Core (BIC) is an open access, on‐line mutation database for breast cancer susceptibility genes. In addition to creating a catalogue of all mutations and polymorphisms in breast cancer susceptibility genes, a principle aim of the BIC is to facilitate the detection and characterization of these genes by providing technical support in the form of mutation detection protocols, primer sequences, and reagent access. Additional information at the site includes a literature review compiled from published studies, links to other internet‐based, breast cancer information and research resources, and an interactive discussion forum which enables investigators to post or respond to questions and/or comments on a bulletin board. Hum Mutat 16:123–131, 2000. Published 2000 Wiley‐Liss, Inc.
ANTIBODIES AGAINST TOXOPLASMA GONDII IN THE AQUEOUS HUMOUR OF PATIENTS WITH ACTIVE RETINOCHOROIDITIS

In active cases of ocular toxoplasmosis, antibodies against the parasite are produced locally in the eye. This antibody production may be revealed by examination of the aqueous humour, and comparing the antibody titer with that of serum. We examined the dye test titer as well as the total IgG concentration of the aqueous humour and serum in 10 patients with active retinochoroiditis. Six of the 10 patients had a significantly higher antibody titer in the aqueous humour than in serum, in relation to their contents of total IgG, proving that the retinochoroiditis was caused by infection with Toxoplasma gondii. Negative results do not exclude the possibility that the inflammation is caused by this parasite. False negative results may occur when the total IgG concentration is either very low, or very high. The time at which the test is performed, in relation to the onset of the inflammation, is also of importance. Our results also suggest that the larger the size of the active lesion is, the higher is the chance of obtaining a definite diagnosis. It is concluded that aqueous humour analysis for antibodies against Toxoplasma gondii should be considered in cases of active retinochoroiditis of unclear or suspected toxoplasmic etiology.
EFFECTS OF EXERCISE ON SOMATOSENSORY-EVOKED POTENTIALS

The aim of this study was to investigate the effect of acute and regular exercise on somatosensory-evoked potentials (SEP). The study group was designed as 9 female and 7 male volleyball players, and the control group as 9 female and 7 male sedentary students. The P1 and P2 latency and amplitude values were measured by tibial nerve stimulation on both lower extremities in the study groups before and after exercise on a treadmill. Intra-group comparison was made to evaluate the acute effects of exercise, and inter-group comparison for the chronic effects of it. Statistically significant difference was determined in pre-exercise right P2 amplitudes and post-exercise left P2 latencies of female volleyball players and sedentary girls. There was significant difference between only the pre-exercise left P2 latency when comparison was made between the sportsmen and sedentary male subject groups. There were significant differences between the pre-exercise left P1 and P2 latency values of sportswomen and right P2 amplitudes of sedentary female subjects. There was no significant difference between left P2 latency values of sportsmen and sedentary male subjects. In conclusion, it was determined that acute and regular exercise shortened the latency of sensory-evoked potentials while decreasing their amplitudes. When evaluating the sensory-evoked potentials in electrophysiology laboratories, the exercise capacity and physical activity levels of the subjects should be considered.
Identification of neonates at risk of developing feeding problems in infancy

The increased survival of sick and preterm neonates may be associated with long‐term problems which must be recognised and managed if outcome is to be optimised. In a prospective study of 35 neonates (median gestational age at birth 34 weeks) admitted to a neonatal intensive care unit over a 3‐month period, we have documented a high incidence (14 of 35) of immature or abnormal feeding patterns when infants were assessed at 36 to 40 weeks postmenstrual age. Neonates with prolonged respiratory support and delayed enteral and oral feeding were most affected. Compared with neonates who have normal initial feeding assessments, neonates with disorganised or dysfunctional feeding were six times more likely to vomit and three times more likely to cough when offered solid food at 6 months of age. At 12 months of age significant differences were also found in tolerating lumpy food and enjoying mealtimes. We hypothesise that these feeding problems contribute to failure to thrive and psychosocial distress after discharge from the neonatal unit and propose potential neonatal measures to reduce their incidence.
Laboratory evaluation of the pivot-shift phenomenon with use of kinetic analysis: a preliminary study.

BACKGROUND Currently, a suitable and reliable noninvasive method to evaluate rotational stability in vivo in anterior cruciate ligament-deficient knees, particularly during sports movements, does not exist. We speculated that if there is a rotational instability, the patient would avoid reaching a high pivoting moment during pivoting activities as a defense mechanism, and that the ground reaction moment, as registered by dynamometric platforms, would be reduced. On the basis of this hypothesis, we developed a study using kinetic analysis to evaluate rotational stability under dynamic loading. METHODS Thirty recreationally active athletes, including fifteen healthy subjects and fifteen with an anterior cruciate ligament-deficient knee, were recruited for this study. Patients performed jumping with pivoting with internal tibial rotation and external tibial rotation on the dynamometric platform with both the healthy and the injured limb. The quantitative results were graphically plotted, and the following parameters were evaluated: loading moment, pivoting moment, torque amplitude, loading slope, pivoting slope, percentage of pivoting with load, loading impulse, pivoting impulse, and maximum body rotation angle. RESULTS There were no significant differences between the dominant and nondominant knees in the control group during the jumping with pivoting and external tibial rotation test with regard to the pivoting moment (p = 0.805), pivoting slope (p = 0.716), pivoting impulse 2 (p = 0.858), and pivoting impulse 3 (p = 0.873). In patients with a chronic tear of the anterior cruciate ligament, there was a significant decrease of the pivoting moment (p = 0.02), pivoting slope (p = 0.005), pivoting impulse 2 (p = 0.006), and pivoting impulse 3 (p = 0.035) during the jumping with pivoting and external tibial rotation test in the anterior cruciate ligament-deficient knee compared with the healthy, contralateral knee. CONCLUSION Kinetic analysis with use of a dynamic platform can objectively detect alterations of rotational stability in anterior cruciate ligament-deficient knees, which may allow this to be a useful research tool for evaluating treatment strategies in patients with anterior cruciate ligament injuries.
Alcohol-Impaired Driving: Average Quantity Consumed and Frequency of Drinking Do Matter

Objective: The objective of this article is to estimate and validate a logistic model of alcohol-impaired driving using previously ignored alcohol consumption behaviors, other risky behaviors, and demographic characteristics as independent variables. Methods: The determinants of impaired driving are estimated using the US Centers for Disease Control and Prevention's (CDC) Behavioral Risk Factor Surveillance System (BRFSS) surveys. Variables used in a logistic model to explain alcohol-impaired driving are not only standard sociodemographic variables and bingeing but also frequency of drinking and average quantity consumed, as well as other risky behaviors. We use interactions to understand how being female and being young affect impaired driving. Having estimated our model using the 1997 survey, we validated our model using the BRFSS data for 1999. Results: Drinking 9 or more times in the past month doubled the odds of impaired driving. The greater average consumption of alcohol per session, the greater the odds of driving impaired, especially for persons in the highest quartile of alcohol consumed. Bingeing has the greatest effect on impaired driving. Seat belt use is the one risky behavior found to be related to such driving. Sociodemographic effects are consistent with earlier research. Being young (18–30) interacts with two of the alcohol consumption variables and being a woman interacts with always wearing a seat belt. Our model was robust in the validation analysis. Conclusions: All 3 dimensions of drinking behavior are important determinants of alcohol-impaired driving, including frequency and average quantity consumed. Including these factors in regressions improves the estimates of the effects of all variables.
Node-Specific Diffusion LMS-Based Distributed Detection Over Adaptive Networks

Diffusion adaptation techniques have shown great promise in addressing the problem of node-specific distributed estimation where the nodes in the network are interested in different, possibly overlapping, sets of parameters. In this work, node-specific distributed detection, which has remained largely unexamined, is considered. In particular, the problem is formulated as one of binary hypothesis testing at each node for each of its parameters of interest. A distributed, online solution for this problem is sought based on diffusion adaptation techniques. In this setting, a signal to be detected by one node constitutes interference that may compromise the ability of the other nodes to detect their signals of interest reliably. Under mild assumptions on the data and network, it is shown that, for sufficiently small adaptation step-sizes, interference can be kept in check. Local detectors are developed where the test-statistics and thresholds adapt to changing conditions in real time. The distributed algorithm is analyzed; and its detection performance characterized and illustrated through numerical simulations.
Internal hydraulic control in the Little Belt , Denmark – observations of flow configurations and water mass formation

Internal hydraulic control, which occurs when stratified water masses are forced through an abrupt constriction, plays an enormous role in nature on both large and regional scales with respect to dynamics, circulation, and water mass formation. Despite a growing literature on this subject surprisingly few direct observations have been made that conclusively show the existence of and the circumstances related to internal hydraulic control in nature. In this study we present observations from the Little Belt, Denmark, one of three narrow straits connecting the Baltic Sea and the North Sea. The observations (comprised primarily of along-strait, detailed transects of salinity and temperature; continuous observations of flow velocity, salinity, and temperature at a permanent station; and numerous vertical profiles of salinity, temperature, fluorescence, and flow velocity in various locations) show that internal hydraulic control is a frequently occurring phenomenon in the Little Belt. The observations, which are limited to south-going flows of approximately twolayered water masses, show that internal hydraulic control may take either of two configurations, i.e. the lower or the upper layer being the active, accelerating one. This is connected to the depth of the pycnocline on the upstream side and the topography, which is both deepening and contracting toward the narrow part of the Little Belt. The existence of two possible flow configurations is known from theoretical and laboratory studies, but we believe that this has never been observed in nature and reported before. The water masses formed by the intense mixing, which is tightly connected with the presence of control, may be found far downstream of the point of control. The observations show that these particular water masses are associated with chlorophyll concentrations that are considerably higher than in adjacent water masses, showing that control has a considerable influence on the primary production and hence the ecosystem in the area.
A tomographic approach to polarimetrie radar cross-section imaging

Three-dimensional radar cross-section (RCS) images are a valuable support for understanding the scattering events occurring at a radar target. Traditional RCS measurement methods require a large angular range and many measurement points to provide sufficient resolution and unambiguousness. This paper proposes the usage of high-resolution techniques, enabled by taking only the polarimetric signal components into account. Therefore, the geometry of a compact antenna test range is integrated into a signal model similar to the one of the direction of arrival (DOA) problem. Subsequently, Bartlett-Beamformer, Multiple Signal Classification (MuSiC) and Deterministic Maximum Likelihood (DML) are adapted and analyzed according to their performance regarding tomographic RCS imaging. The validation of this approach is done by measuring a reference target's RCS along three dimensions. A comparison of the results of the three algorithms is provided in the end, constituting the advantages of MuSiC.
Lignocellulosic composites from brazilian giant bamboo (Guadua magna) Part 1: Properties of resin bonded particleboards

This experiment evaluated the utilization of the recently identified Brazilian giant bamboo, Guadua magna (Londono & Filg.) to manufacture medium density particleboard. Four board types were tested: two of them exclusively with particles of bamboo and two in a mixture of bamboo with Pinus taeda wood particles. The target density of the panels was 0.65 g/cm3 for all treatments. The particleboards were bonded using 8% content of urea-formaldehyde (UF) and phenol-formaldehyde (PF) resins, based on dry weight mat. Mechanical, physical and nondestructive properties of the panels were assessed. The particleboards produced with PF showed better dimensional stability than UF particleboards. The addition of wood particles improved the mechanical properties of EM, fM and IB. The flexural properties of the panels (EM, fM) could be modeled using either EMd or density and the models fitted presented high predictability (>66%).
Long-Term Outcomes of Endovascular Therapy for Aortoiliac Bifurcation Lesions in the Real-AI Registry

Purpose To report long-term outcomes of endovascular therapy (EVT) for aortoiliac bifurcation lesions. Methods Patients enrolled in the multicenter REtrospective AnaLysis of Aorto-Iliac stenting (REAL-AI) registry in Japan were pooled. Of 2096 patients who underwent EVT for de novo aortoiliac disease between January 2005 and December 2009, 190 patients (148 men; mean age 70±9 years) had aortoiliac bifurcation lesions that were treated with stents, whose configuration (single, V, or kissing) and type (balloon-expandable or self-expanding) were subjected to regression analysis to determine any impact on primary patency along with other demographic, clinical, and lesion characteristics, including Trans-Atlantic Inter-Society Consensus II C/D classification. The primary endpoints were restenosis and target lesion revascularization (TLR). Secondary endpoints were all-cause death, major cardiovascular events, and major cardiovascular + limb events. Results The overall complication rate was 6.3%, and 1- and 5-year primary patency rates were 87% and 73%, respectively. Over a mean follow-up of 31±15 months, there were 36 (19.0%) restenoses, 22 (11.6%) TLRs, and 4 (2.1%) reocclusions; stent fracture (2, 1.1%) and major amputation (2, 1.1%) were rare. Only female gender [adjusted hazard ratio (AHR) 4.26, 95% CI 1.89 to 9.71, p<0.001] and residual diameter stenosis (AHR 1.04, 96% CI 1.01 to 1.06, p=0.01) were independent predictors of primary patency. Conclusion Stenting for aortoiliac bifurcation lesions was found to be safe and effective. Neither stent configuration nor type appeared to affect vessel patency in true bifurcation lesions.
Ultrastable particle-stabilized foams.

Pump up the volume: Wet foams prepared with surfactants are thermodynamically unstable systems that undergo rapid disproportionation, drainage, and coalescence. Ultrastable foams have now been prepared using colloidal particles as stabilizers (left picture). The stabilization results from the irreversible adsorption at the air–water interface of particles surface-modified with short-chain amphiphiles (right picture).
Pyridostigmin (mestinon) as an antagonist of d-tubocurarine.

The effects of pyridostigmin were compared with those of edrophonium and neostigmine in anesthetized patients. Pyridostigmin was superior to edrophonium and equal to neostigmine as an antagonist ofd-tubocurarine. Pyridostigmin produced fewer oropharyngeal secretions and decreased the heart rate less than did neostigmine. Further clinical studies of pyridostigmin should be carried out to confirm or deny this initial favorable experience. It is recommended that adequate recovery from neuromuscular block be defined as return of twitch height to the control level and, more important, the restoration of well sustained tetanus (30 cps.) to the level seen prior to the administration of any neuromuscular blocking agents.
RT2: A Real-Time Ray-Tracing method for acoustic distance evaluations among cooperating AUVs

The paper deals with the problem of distributed acoustic localization of teams of Autonomous Underwater Vehicles (AUVs) and proposes a novel algorithm, Real-Time Ray-Tracing (RT2), for evaluating the distance between any pair of AUVs in the team. The technique, based on a modified formulation of the non-linear sound-ray propagation laws, allows efficiently handling the distorted and reflected acoustic ray paths, induced by the anisotropy of the underwater medium. Further it can be easily implemented on-board of low-cost AUVs. Indeed it just requires the presence, on each vehicle, of a simple acoustic modem and a pair of look-up tables, a-priori constructed via the assumed knowledge of the depth-dependent sound velocity profile. On such a basis, every AUV can easily on-line compute its distance w.r. t. to any other neighbour team member, through time-of-flight measurements and the exchanges of depth information only. Further, since the proposed RT2 algorithm makes available accurate distance evaluations (despite the distorted acoustic rays), the effective filtering techniques normally used by terrestrial mobile robots for distributed localization are expected to be transferable to the underwater field.
Learning to share.

The unveiling of the draft sequence of the human genome in 2000 was met with enthusiastic predictions about how genomics would dramatically change the treatment of diseases such as cancer. The years since have brought a 100,000-fold drop in the cost of sequencing a human genome (to just a few thousand US dollars), and the time needed to sequence it has been cut from months to little more than a day. Researchers can therefore now generate unprecedented quantities of data to help in the battle against cancer (see page S20).
Performance Analysis of Iterative Decoding Algorithms with Memory over Memoryless Channels

Density evolution is often used to determine the performance of an ensemble of low-density parity-check (LDPC) codes under iterative message-passing algorithms. Conventional density evolution techniques over memoryless channels are based on the assumption that messages at iteration ℓ are only a function of the messages at iteration ℓ -1 and possibly the channel output. This assumption is valid for many algorithms such as standard belief propagation (BP) and min-sum (MS) algorithms. However, there are other important iterative algorithms such as successive relaxation (SR) versions of BP and MS, and differential decoding with binary message passing (DD-BMP) algorithm of Mobini et al., for which this assumption is not valid. The reason is the introduction of memory in these algorithms. In this work, we propose a model for iterative decoding algorithms with memory which covers SR and DD-BMP algorithms as special cases. Based on this model, we derive a Bayesian network for iterative algorithms with memory over memoryless channels and use this representation to analyze the performance of the algorithms using density evolution. The density evolution technique is developed based on truncating the memory of the decoding process and approximating it with a finite order Markov process, and can be implemented efficiently. As an example, we apply our technique to analyze the performance of DD-BMP on regular LDPC code ensembles, and make a number of interesting observations with regard to the performance/complexity tradeoff of DD-BMP in comparison with BP and MS algorithms. The model presented in this paper is based on certain simplifying assumptions about the memory structure of iterative algorithms such as the existence of memory only at the output of variable nodes in the code's Tanner graph rather than at both outputs of variable and check nodes. The Bayesian network framework introduced here however, can still be used to analyze the more general scenarios.
Prerequisites for electronic learning: Iranian postgraduate nursing students’ points of view

Background: Nursing education is mostly conducted through electronic educational programs. We aimed at assessing the Iranian postgraduate nursing students’ skills and attitudes regarding the electronic education. Materials and Methods: Ninety-seven postgraduate nursing students were surveyed using questionnaires assessing their individual-social and educational characteristics, electronic education skills, and attitudes toward the electronic education. Results: Scores of the students’ skills in using computer and the Internet were significantly associated with gender and the number of hours working with computer and the Internet at home and work. Conclusion: Prerequisites for performing electronic education programs are present at moderate levels in Iran.
Penicillin-nonsusceptible Streptococcus pneumoniae at San Francisco General Hospital.

Positive pneumococcal cultures of specimens from adult inpatients at San Francisco General Hospital (SFGH) during the period of 11 August 1994 through 31 December 1996 were identified retrospectively. Of the isolates recovered, 15.5% were not penicillin-susceptible (MIC, > or =.1 microg/mL). A case-control study was performed to evaluate risk factors for colonization or infection with penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) and outcomes. Cases (n = 65) were adult inpatients with a positive culture for PNSP, and controls (n = 411) were adult inpatients with a positive culture for penicillin-susceptible pneumococci (PSSP) and no evidence of PNSP. Cases were less likely to have pneumococcal bacteremia (15.4% versus 39.4%; P<.001) and less likely to have pneumonia (50.8% versus 68.9%; P = .006). In a multiple logistic regression model, recent hospital admission and absence of bacteremia were independent predictors of penicillin-nonsusceptibility. Human immunodeficiency virus infection, mortality, and length of hospitalization were not significantly different among cases and controls. These data suggest that PNSP may be less virulent (cause less pulmonary infection) and/or less invasive (cause fewer bloodstream infections) than PSSP at SFGH.