Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and determinants of pain and pain-related disability in urban and rural settings in southeastern Ontario.

BACKGROUND Canadian chronic pain prevalence estimates range from 11% to 66%, are affected by sampling and measurement bias, and largely represent urban settings. OBJECTIVES To estimate chronic pain prevalence and factors associated with pain in southeastern Ontario, a region with a larger rural than urban residence. METHODS A systematic sampling with a random start was used to contact households. A telephone-administered questionnaire using the Graded Chronic Pain Scale, with questions on health care and medication use, health status, depression and demographics, was administered to consenting adults (18 to 94 years of age; mean age 50.2+/-16.6 years). RESULTS The response rate was 49% (1067 of 2167), with 76% reporting some pain over the past six months. Low pain intensity with low pain interference prevalence was 34% (grade I), high pain intensity with low pain interference was 26% (grade II), and high pain intensity with high pain interference was 17% (grades III and IV). Of those reporting pain, 49% reported chronic pain (ie, pain for a minimum of 90 days over the past six months) representing 37% of the sample. Being female, unmarried, lower income, poorer self-reported health status and rural residence were associated with increasing pain. Once depression was considered in this pain analysis, residence was no longer significant. Lower rates of health care utilization were reported by rural residents. In those reporting the highest pain grades, poor health, greater medication and health care use, depression and more pain sites were associated with higher odds for pain-related disability. CONCLUSION There is an elevated prevalence of pain in this almost equally split rural/urban region. Further examination of health care utilization and depression is suggested in chronic pain prevalence research.
Gaia 20eae: A Newly Discovered Episodically Accreting Young Star

The Gaia Alert System issued an alert on 2020 August 28, on Gaia 20eae when its light curve showed a ∼4.25 magnitude outburst. We present multiwavelength photometric and spectroscopic follow-up observations of this source since 2020 August and identify it as the newest member of the FUor/EXor family of sources. We find that the present brightening of Gaia 20eae is not due to the dust-clearing event but due to an intrinsic change in the spectral energy distribution. The light curve of Gaia 20eae shows a transition stage during which most of its brightness (∼3.4 mag) has occurred on a short timescale of 34 days with a rise rate of 3 mag/month. Gaia 20eae has now started to decay at a rate of 0.3 mag/month. We have detected a strong P Cygni profile in Hα, which indicates the presence of winds originating from regions close to the accretion. We find signatures of very strong and turbulent outflow and accretion in Gaia 20eae during this outburst phase. We have also detected a redshifted absorption component in all of the Ca ii IR triplet lines consistent with a signature of hot infalling gas in the magnetospheric accretion funnel. This enables us to constrain the viewing angle with respect to the accretion funnel. Our investigation of Gaia 20eae points toward magnetospheric accretion being the phenomenon for the current outburst.
Acquisition of High-Risk Human Papillomavirus Infections and Pap Smear Abnormalities among Women in the New Independent States of the Former Soviet Union

ABSTRACT The rates of acquisition and the times of incident high-risk (HR) human papillomavirus (HPV) infections and Pap smear abnormalities and their predictive factors were analyzed in women participating in a multicenter screening study in three countries of the New Independent States of the former Soviet Union. The 423 patients were prospectively monitored for a mean of 21.6 months. At the baseline, 118 women were HR HPV DNA negative (Hybrid Capture II assay) and Pap smear negative (group 1), 184 were HPV DNA positive and Pap smear negative (group 2), and 121 were HPV DNA negative and Pap smear positive (group 3). The time to the acquisition of an incident abnormal Pap smear (19.4 months) was significantly longer in group 1 than in group 2 (9.2 months) (P = 0.0001). The times of acquisition of incident HR HPV infection were 16.6 and 11.0 months in group 1 and group 3, respectively (P = 0.006). The monthly rates of acquisition of incident HR HPV infections were very similar in group 1 (1.0%) and group 3 (0.8%), whereas the rate of acquisition of an abnormal Pap smear was significantly higher in group 2 (3.1%) than in group 1 (1.5%) (P = 0.0001). The acquisition of HR HPV infection (but not a positive Pap smear result) was significantly (P = 0.0001) age dependent. The only significant independent (P = 0.001) predictor of the incidence of an abnormal Pap smear result was a high HR HPV load of >20 relative light units/control value (CO) (rate ratio, 2.050; 95% confidence interval, 1.343 to 3.129). Independent predictors of incident HR HPV infection were patient category (a sexually transmitted disease) and ever having been pregnant. The time of acquisition of HR HPV infection was 3 months shorter than that of an abnormal Pap smear. At the baseline the high load of a particular HR HPV type is the single most important predictor of an incident Pap smear abnormality, whereas young age and having a sexually transmitted disease predict incident HR HPV infections.
A Major Fraction of Fibronectin Present in the Extracellular Matrix of Tissues Is Plasma-derived*

The origin of the fibronectin (FN) found in the extracellular matrix of tissues has not been defined experimentally. Previous studies suggest that there is contribution from both local tissue production and transfer from plasma, but the extent of this phenomenon has not been addressed. We have shown before that engineered mice constitutively expressing extra domain A-containing FN (EDA+FN) have a significant decrease of FN levels in plasma and most tissues. We showed that hepatocytes modified to produce EDA+FN have normal extracellular matrix-FN levels but secrete less soluble FN. When we performed a liver-specific EDA-exon deletion in these animals, FN levels were restored both in plasma and tissues. Therefore, an important fraction of tissue FN, approximately an equal amount of that produced by the tissue itself, is actually plasma-derived, suggesting that plasma is an important source of tissue FN. The present results have potential significance for understanding the contributions of plasma FN, and perhaps other plasma proteins, in the modulation of cellular activities and in the formation of the extracellular matrix of tissues.
The Effect of Degree of Recycle on the Nitrifier Growth Rate

The nitrifier maximum specific growth rate, μA,max, is a critical parameter for the design and performance of nitrifying activated sludge systems. Although many investigations studied μA,max, only a few have dealt with the effect of the reactor configuration on this important kinetic parameter. Bench‐ and full‐scale trials were devised to study the effect of the internal mixed‐liquor recycle (IMLR) on the nitrifier growth rate constant. The nitrifier growth rate constant for an existing activated sludge plant was determined at different operational conditions using the high food‐to‐microorganism ratio (F/M) test and by process model calibration. Overall, the results obtained during this study indicate that high IMLR values have a negative effect on μA,max. Based on the results obtained during this investigation, a 15% decrease in μA,max was observed at an IMLR of 4Q or higher. It is surmised that, at high IMLRs, the reactor behavior shifts from a plug‐flow configuration to a “quasi” complete‐mix configuration, influencing either the species selection in activated sludge population or at least the adaptation of specific species. These results have a tremendous effect on the design of activated sludge processes that incorporate IMLR for denitrification, such as the Bardenpho, Modified Ludzack‐Ettinger (MLE), University of Cape Town (UCT), and Phoredox or anaerobic‐anoxic‐aerobic (A2/O) processes.
Behavioural variant Frontotemporal Dementia: Not all it seems?

Background: The diagnosis of the behavioural variant of frontotemporal dementia (bvFTD) can be challenging. At present there is a paucity of prospective work addressing the specificity of current diagnostic criteria for bvFTD with respect to long-term outcome (i.e., false positives versus true positives). Methods: Here we report two individuals who met current clinical criteria for bvFTD and who underwent detailed long-term clinical and neuropsychological follow-up. In addition, both had serial volumetric MRI and functional metabolic (FDG-PET) imaging separated by 5 years. Results: One case had a slow clinical decline as well as both progressive atrophy and hypometabolism in a frontotemporal distribution, consistent with a neurodegenerative FTD syndrome. However, the second developed neither atrophy nor hypometabolism and remained clinically stable, a decade from symptom onset. Conclusion: We propose that these cases illustrate that while there may be a slow evolution in bvFTD, it is possible that some cases who meet current criteria may not have a neurodegenerative syndrome. If correct, this hypothesis has important implications for the current diagnostic criteria. A potential hierarchy for diagnostic certainty in bvFTD is suggested.
Recent Advances in Mammalian Target of Rapamycin Inhibitor Use in Heart and Lung Transplantation

Abstract The mammalian target of rapamycin (mTOR) inhibitors sirolimus and everolimus are increasingly used in cardiothoracic transplantation. Several recent clinical trials have demonstrated their efficacy in combination with reduced cyclosporine dosing in de novo heart transplant recipients, in particular with everolimus. A number of other studies have demonstrated their efficacy for improving renal function and reducing calcineurin inhibitor use, attenuating cardiac allograft vasculopathy progression and reducing cytomegalovirus infections in maintenance heart transplant populations. A growing body of literature, including a small number of clinical trials, now describes the use mTOR inhibitors in lung transplant recipients. The benefits in this population include improved lung and renal function in limited studies. Considerably less evidence is available in pediatric heart transplantation, though similar indications in the maintenance therapy population have been described. The benefits of mTOR inhibitors must be weighed against the increased risk of adverse events and drug intolerance compared with other primary immunosuppressants, and discontinuation rates are particularly high in lung transplant recipients. The risks of surgical wound healing complications in transplant recipients receiving mTOR inhibitors previously or actively supported by mechanical circulatory support devices remains poorly described in the current literature. The current role and recent evidence for mTOR inhibitor use in heart and lung transplantation is examined in this review.
Brain Lesions in Pigs Affected with Postweaning Multisystemic Wasting Syndrome

Anti-porcine circovirus type 2 (anti-PCV2) immunostaining was associated with cerebellar lymphohistiocytic vasculitis combined with hemorrhages (50 pigs) or with lymphohistiocytic meningitis (23 pigs) in pigs naturally affected with postweaning multisystemic wasting syndrome (PMWS). The animals originated from 12 farms in Rio Grande do Sul, Brazil. In total, 456 unthrifty 3- to 5-month-old postweaning pigs confirmed as PMWS cases were necropsied. Although most findings mimicked those extensively reported in PMWS-affected pigs, there were distinctive brain lesions that included multiple hemorrhages in the cerebellar leptomeninges associated with lymphohistiocytic vasculitis and fibrinoid degeneration in vessels of the cerebellum and periventricular areas (69 pigs). These vascular lesions were also seen in conjunction with lymphohistiocytic meningitis (38 additional pigs). PCV2 antigen was immunohistochemically demonstrated in the cytoplasm and nuclei from intralesional perivascular macrophages and endothelial-like cells in brain tissues. Together these findings suggest that these lesions were caused by PCV2.
Quantitative Analysis of Benzodiazepine Receptor in Temporal Lobe Epilepsy: [125I]Iomazenil Autoradiographic Study of Surgically Resected Specimens

Summary: Purpose: To evaluate the changes of the inhibitory neurotransmitter receptor system related to epileptogenesis by measuring central benzodiazepine receptors (BZDRs) in surgically resected specimens of temporal lobe epilepsy by using [125I]iomazenil autoradiography.
Epidermal patterning genes impose non-cell autonomous cell size determination and have additional roles in root meristem size control.

The regulation of cellular growth is of vital importance for embryonic and postembryonic patterning. Growth regulation in the epidermis has importance for organ growth rates in roots and shoots, proposing epidermal cells as an interesting model for cellular growth regulation. Here we assessed whether the root epidermis is a suitable model system to address cell size determination. In Arabidopsis thaliana L. , root epidermal cells are regularly spaced in neighbouring tricho- (root hair) and atrichoblast (non-hair) cells, showing already distinct cell size regulation in the root meristem. We determined cell sizes in the root meristem and at the onset of cellular elongation, revealing that not only division rates but also cellular shape is distinct in tricho- and atrichoblasts. Intriguingly, epidermal-patterning mutants, failing to define differential vacuolization in neighbouring epidermal cell files, also display non-differential growth. Using these epidermal-patterning mutants, we show that polarized growth behaviour of epidermal tricho- and atrichoblast is interdependent, suggesting non-cell autonomous signals to integrate tissue expansion. Besides the interweaved cell-type-dependent growth mechanism, we reveal an additional role for epidermal patterning genes in root meristem size and organ growth regulation. We conclude that epidermal cells represent a suitable model system to study cell size determination and interdependent tissue growth.
Do outcomes vary according to the source of admission to the pediatric intensive care unit?*

Objective: To examine associations between mortality, length of stay, and the sources of admission to tertiary pediatric intensive care. Design: A retrospective analysis of prospectively collected data. Setting: A tertiary medical center with a 16-bed medical-surgical intensive care unit and a 15-bed cardiac pediatric intensive care unit (PICU). Patients: All admissions from July 1, 1998, through June 30, 2004. Multivariable regression methods compared length of stay and mortality between the sources of PICU admission, controlling for multiple variables, including severity of illness. Interventions: None. Measurements and Main Results: Of 8,897 eligible admissions, 74% were directly from the study hospital’s emergency department or operating rooms, while 26% were from indirect sources, including the study hospital’s wards (11%) or interhospital transfer from either non-PICU (12%) or PICU settings (3%). Compared with emergency department admissions, ward admissions had higher odds of mortality (odds ratio 1.65, 95% confidence interval 1.08–2.51), transfer admissions from non-PICU settings did not have elevated odds of mortality (odds ratio 0.80, 95% confidence interval 0.51–1.25), and inter-PICU transfer admissions had higher odds of mortality (odds ratio 1.43, 95% confidence interval 0.80–2.56), although not reaching statistical significance. Compared with emergency department admissions, ward admissions stayed almost 4 days longer in the PICU, while interhospital transfer admissions from non-PICU and PICU settings stayed 2 and 6 days longer, respectively. Conclusions: Outcomes of tertiary pediatric intensive care vary significantly by source of admission. Strategies aimed at reduction of mortality at the tertiary PICU should target transfer admissions from the hospital’s wards and from PICUs of other hospitals.
Spontaneous intracranial hemorrhage: which patients need diagnostic cerebral angiography? A prospective study of 206 cases and review of the literature.

BACKGROUND AND PURPOSE In spontaneous intracerebral hemorrhage (ICH), the site, age of the patients, and preexisting hypertension are important factors in determining the possibility of finding an underlying vascular abnormality by cerebral angiography. To what extent these three factors affect the indication for angiography remains controversial. A prospective study was carried out to correlate the angiographic findings with these three factors. METHODS Two hundred six consecutive spontaneous ICH cases with an age range from 5 to 79 years (median, 45) were investigated with CT and cerebral angiography over a 3-year period (April 1993 through March 1996). Exclusion criteria were (1) poor surgical risk or severely neurologically disabled patients, (2) refusal of angiography, (3) patients in whom severe coagulopathy accounted for the hemorrhage, (4) bleeding into tumor, or (5) subarachnoid hemorrhage-predominant cases. RESULTS Angiographic yield (the frequency of positive angiography in a defined patient group) was significantly higher in patients (1) at or below the median age of 45 than those above (53/105, 50%, versus 18/101, 18%; P < .001) and (2) without preexisting hypertension than those with (64/145, 44%, versus 5/58, 9%; P < .001). The correlation of age and preexisting hypertension to angiographic yield was independent (logistic regression coefficients -0.056 and -1.59 and SE 0.12 and 0.515, respectively, both P < .001). In patients of the younger age group without preexisting hypertension, angiographic yield was 48% in putaminal, thalamic, or posterior fossa ICH and 65% in lobar ICH. In the older hypertensive patients, the yields were 0% and 10%, respectively. However, in patients with isolated intraventricular hemorrhage, most were normotensive and the yield was high in both age groups (67% versus 63%). CONCLUSION Diagnostic cerebral angiography should be considered for all spontaneous ICH patients except those over 45 years old with preexisting hypertension in thalamic, putaminal, or posterior fossa hemorrhage.
Cytoplasmic calcium transients due to single action potentials and voltage‐clamp depolarizations in mouse pancreatic B‐cells.

Changes in the cytoplasmic free calcium concentration ([Ca2+]i) in pancreatic B‐cells play an important role in the regulation of insulin secretion. We have recorded [Ca2+]i transients evoked by single action potentials and voltage‐clamp Ca2+ currents in isolated B‐cells by the combination of dual wavelength emission spectrofluorimetry and the patch‐clamp technique. A 500–1000 ms depolarization of the B‐cell from −70 to −10 mV evoked a transient rise in [Ca2+]i from a resting value of approximately 100 nM to a peak concentration of 550 nM. Similar [Ca2+]i changes were associated with individual action potentials. The depolarization‐induced [Ca2+]i transients were abolished by application of nifedipine, a blocker of L‐type Ca2+ channels, indicating their dependence on influx of extracellular Ca2+. Following the voltage‐clamp step, [Ca2+]i decayed with a time constant of approximately 2.5 s and summation of [Ca2+]i occurred whenever depolarizations were applied with an interval of less than 2 s. The importance of the Na(+)‐Ca2+ exchange for B‐cell [Ca2+]i maintenance was evidenced by the demonstration that basal [Ca2+]i rose to 200 nM and the magnitude of the depolarization‐evoked [Ca2+]i transients was markedly increased after omission of extracellular Na+. However, the rate by which [Ca2+]i returned to basal was not affected, suggesting the existence of additional [Ca2+]i buffering processes.
Social Capital and Entrepreneurial Outcomes: Evidence from Informal Sector Entrepreneurs in Ethiopia

In Africa, social capital (SC) is an important resource for the informal economy. It substitutes the limited formal business support systems as factor inputs for enterprise development. This article investigates the effect of Burt’s structural holes theory of social capital in the context of the Ethiopian informal economy. Data were collected from street entrepreneurs in Addis Ababa using multiple name generators constructed on the basis of entrepreneurs’ frequent interaction with people related to resources needed for entrepreneurial activities. Social network analyses and statistical procedures of instrumental variables estimation were used to analyse the data. By controlling the potential endogeneity problem between structural holes and enterprise outcomes, the findings of the study show that entrepreneurs’ dense network structure, which lacks structural holes, has a significant negative effect on entrepreneurial outcome. Accordingly, policies that aim at supporting informal entrepreneurs need to consider the benefits of social contacts while taking into account the downside of being excessively embedded in dense networks.
Inclusive parliaments: a trigger for higher electoral integrity?

ABSTRACT Free, fair and transparent elections are a prerequisite for the functioning of democracy. In a functioning democracy, the integrity of elections guarantees high citizens’ trust in the democratic system; in a new or fledgling democracy fair and transparent elections help to consolidate the regime. In this article, the authors test whether inclusive parliaments improve the fairness and objectivity of elections. Using data from more than 100 elections, the authors establish through descriptive and inferential statistics that only one of the three indicators of inclusiveness – women’s representation, minority representation and average age – namely women’s representation, significantly improves the fairness and transparency of elections.
Quantifying low back peak and cumulative loads in open and senior sheep shearers in New Zealand: Examining the effects of a trunk harness

Sheep shearing requires shearers to adopt sustained flexed postures for prolonged periods of time and has been associated with an increased risk of developing low back pain (LBP). However, these postures do not generally result in acute compressive values at L4/L5 exceeding the action limit proposed by the National Institute for Occupational Safety and Health, despite the high prevalence of LBP in this occupation. Therefore, it may not be peak loading that is responsible for LBP in this occupation but instead it may be the effect of cumulative loading over the course of a workday. The primary purpose of this research was to quantify the low back cumulative load exposure in 12 sheep shearers with and without the aid of a commercial trunk harness. Results revealed a significant reduction in the magnitude of cumulative compression with the use of the trunk harness and therefore its use may potentially reduce the risk of injury. The use of the trunk harness also reduced the time spent in axially twisted postures, which have been associated with LBP. However, using the trunk harness also resulted in increased time spent in laterally bent postures, which has been associated with increased risk for pain and injury.