Miracle-dz/UniFAR-FTUs huggingface dataset:
A medication screening trial evaluation of reserpine, gabapentin and lamotrigine pharmacotherapy of cocaine dependence.

AIMS To conduct a preliminary evaluation of the safety and efficacy of reserpine, gabapentin or lamotrigine versus an unmatched placebo control as a treatment for cocaine dependence. DESIGN A 10-week out-patient study using the Cocaine Rapid Efficacy and Safety Trial (CREST) study design. SETTING The study was conducted at the Cincinnati Medication Development Research Unit (MDRU). PARTICIPANTS Participants met Diagnostic and Statistical Manual version IV (DSM-IV) criteria for cocaine dependence. Sixty participants were enrolled, with 50 participants completing the final study measures. INTERVENTION The targeted daily doses of medication were reserpine 0.5 mg, gabapentin 1800 mg and lamotrigine 150 mg. All participants received 1 hour of manualized individual cognitive behavioral therapy on a weekly basis. MEASUREMENTS Primary outcome measures of efficacy included urine benzoylecgonine (BE) level, Cocaine Clinical Global Impression scale--observer and self-report of cocaine use. Safety measures included adverse events, electrocardiograms (ECGs), vital signs and laboratory tests. FINDINGS Subjective measures of cocaine dependence indicated significant improvement for all study groups. Urine BE results indicated a significant improvement for the reserpine group (P < 0.05) and non-significant changes for the other study groups. No pattern of physical or laboratory abnormalities attributable to treatment with any of the medications was identified. There were three serious adverse events reported, none of which were related to study procedures. The medications appeared to be tolerated well. CONCLUSIONS The present findings suggest that reserpine may be worthy of further study as a cocaine dependence treatment.
Academic resilience and buoyancy in second-level schools: understanding and supporting student success

vii Declaration. vii Acknowledgements: . ix Chapter One: Introduction . 10 1.0 Introduction: Placing Resilience and Buoyancy in context . 10 1.1 Research Problem . 12 1.2 Overview of the Research Methodology . 13 1.3 Outline of Thesis . 15 1.4 Author’s reflection . 16 1.5 Chapter Summary . 19 Chapter Two: Educational Disadvantage . 20 2.0 Introduction . 20 2.1 Definitions and Theoretical Perspectives . 21 2.2 Empirical Data on ‘Disadvantage’ in Ireland . 28 2.3 Chapter Summary . 37 Chapter Three: Adolescence from Sociological and Psychological Perspectives . 40 3.0 Introduction . 40 3.2 Defining Adolescence – a 20 century construction . 42 3.3 Adolescence: identity and subculture . 45 3.4 Chapter Summary . 62 Chapter Four: Perspectives on Academic Resilience and Buoyancy. 65 4.0 Introduction . 65 4.1 The Origins of Academic Resilience and Buoyancy: A historical overview . 66 4.2 How young people experience autonomy in school . 72 4.3 Contemporary Discourse: The emergence of Academic Buoyancy . 81 4.4 Furthering our understanding: Habitus and Practice . 86 4.5 Chapter Summary . 95 Chapter Five: Methodology . 97 5.0 Introduction . 97 5.1 The Research Questions . 97 5.2 Perspectives in social research . 98 5.3 Data Collection Methods . 106 5.4 Ethics . 133 5.5 Chapter Summary . 137 Chapter Six: Findings: Case Study of Smithstown College . 139
The Fate of Radioiodinated Endothelin‐1 and Endothelin‐3 in the Rat

Summary Endothelin-1 (ET-1) has been isolated from cultured endothelial cells and might have a role in cardiovascular regulation. To study the fate of labeled ET-1, we prepared [125I]-labeled ET-1 (formerly porcine and human ET) and ET-3 (formerly rat ET). Approximately 0.2 $mUCi (0.2 pmol) was injected into the left ventricle of anesthetized rats and blood samples analyzed for radioactivity for up to 40 min. The animals were then killed and the distribution of radioactivity determined in various organs. Both ET-1 and ET-3 were rapidly removed from the circulation, with more than 60% of the removal occurring in the first minute. Removal of ET-1 was somewhat faster than that of ET-3. The highest uptake of radioactivity was seen in lung, kidney, and liver. When ET-1 was infused into the isolated perfused lung of the guinea pig, 64 $$ 1.9% of the label was retained. Subcellular fractionation of the lung homogenate following infusion of labeled ET-1 showed that 93% of the label was associated with membranes and intracellular organelles, suggesting internalization of the bound ET-1. Together, the results indicate a high density of ET-1 binding sites in the lung, liver, and kidney and that these organs may be important in removing circulating ET-1.
The Acute Effects of a Caffeine-Containing Supplement on Bench Press Strength and Time to Running Exhaustion

Beck, TW, Housh, TJ, Malek, MH, Mielke, M, and Hendrix, R. The acute effects of a caffeine-containing supplement on bench press strength and time to running exhaustion. J Strength Cond Res 22(5): 1654-1658, 2008-The purpose of the present study was to examine the acute effects of a caffeine-containing supplement (SUPP) on one-repetition maximum (1-RM) bench press strength and time to running exhaustion (TRE) at a velocity that corresponded to 85% of the peak oxygen uptake (&OV0312;O2peak). The study used a double-blinded, placebo-controlled, crossover design. Thirty-one men (mean ± SD age = 23.0 ± 2.6 years) were randomly assigned to take either the SUPP or placebo (PLAC) first. The SUPP contained 201 mg of caffeine, and the PLAC was microcrystalline cellulose. All subjects were tested for 1-RM bench press strength and TRE at 45 minutes after taking either the SUPP or PLAC. After 1 week of rest, the subjects returned to the laboratory and ingested the opposite substance (SUPP or PLAC) from what was taken during the previous visit. The 1-RM bench press and TRE tests were then performed in the same manner as before. The results indicated that the SUPP had no effect on 1-RM bench press strength or TRE at 85% &OV0312;O2peak. It is possible that the acute effects of caffeine are affected by differences in training status and/or the relative intensity of the exercise task. Future studies should examine these issues, in addition to testing the acute effects of various caffeine doses on performance during maximal strength, power, and aerobic activities. These findings do not, however, support the use of caffeine as an ergogenic aid in untrained to moderately trained individuals.
Type 1 diabetes: role of intestinal microbiome in humans and mice

Type 1 diabetes is a disease involving autoimmune destruction of pancreatic beta cells in genetically predisposed individuals. Identifying factors that trigger initiation and progression of autoimmunity may provide opportunities for directed prophylactic and therapeutic measures to prevent and/or treat type 1 diabetes. The human intestinal microbiome is a complex, symbiotic ecological community that influences human health and development, including the development and maintenance of the human immune system. The role of the intestinal microbiome in autoimmunity has garnered significant attention, and evidence suggests a particular role for intestinal microbiome alterations in autoimmune disease development, including type 1 diabetes. This review will examine the role of the intestinal microbiome in the development and function of the immune system and how this relates to the development of autoimmunity. Data from animal and human studies linking alterations in the intestinal microbiome and intestinal integrity with type 1 diabetes will be closely examined. Finally, we will examine the interactions between the intestinal microbiome and dietary exposures and how these interactions may further influence autoimmunity and type 1 diabetes development.
Intradialytic exercise improves physical function and reduces intradialytic hypotension and depression in hemodialysis patients

Background/Aims As numbers of maintenance hemodialysis patients are growing, debilitating conditions of muscle wasting and atrophy are becoming some of the greatest concerns in end-stage renal disease patients. Exercise training has various potential benefits in terms of prevention of a sustained decline in functional status. This study aimed to evaluate the physical, psychological, laboratory, and dialysis-related effects of intradialytic exercise. Methods We enrolled 22 patients from a hemodialysis center for a 6-month non-randomized prospective trial. Combination of aerobic exercise with bicycle ergometer and anaerobic exercise with elastic bands was conducted during hemodialysis. Data including physical fitness test results, dialysis-related measurements, and biochemical laboratory results were collected at baseline, 3, and 6 months. Depression and quality of life were assessed using Beck Depression Inventory and Short Form-36 health survey. Results After exercise completion, there were significant improvements in back muscle power, forward and backward trunk flexibility, vertical jump, elbow flexion, sit to stand test, and 6-minute walk test (p < 0.05). No significant changes were observed in dry weight, blood pressure, Kt/V, and biochemical variables, except for intradialytic hypotension (p < 0.05). For depression, Beck Depression Inventory showed statistically significant enhancement (p < 0.05). Scores of Short Form-36 health survey did not show significant increase in each domain, except for bodily pain (p < 0.05). Conclusions Combined aerobic and anaerobic exercise training during dialysis was found to be effective on physical health status, intradialytic hypotension, and depression in terms of mental health. Therefore, the findings of the current study may provide an appropriate guidance for encouraging exercise by nephrologists.
Controlled release formulations of acephate: Water and soil release kinetics

Controlled release formulations of insecticide acephate (O,S-dimethyl acetylphosphoramidothioate) have been prepared using commercially available polyvinyl chloride, carboxy methyl cellulose and carboxy methyl cellulose with kaolinite. Kinetics of acephate release in soil and water from the different formulations was studied in comparison with the commercially available formulation 75 DF. Release from the commercial formulation was faster than the new controlled pesticide release (CR) formulations. Addition of clay in the carboxy methyl cellulose matrix reduced the rate of release. The diffusion exponent (n value) of acephate in water and soil ranged from 0.462 to 0.875 and 0.420 to 0.547 respectively in the tested formulations. The release was diffusion controlled with a half release time (T1/2) of 2.97 to 52.41 days in water and 2.98 to 76.38 days in soil from different matrices. The maximum release of acephate in water and soil from controlled released formulations occurred between 6.33 to 36.34 and 12.49 to 29.09 days respectively. The results suggest that depending upon the polymer matrix used, the application rate of acephate can be optimized to achieve insect control at the desired level and period.
Influence of load impedances on the quality of Power Line Communication

Advanced communication technologies have allowed power-line-communication (PLC) channel to be a transmission medium that enables the transfer of high-speed digital data over the classical indoor electrical wires. The development of PLC systems for Internet, voice, and data services requires measurement-based models of the transfer characteristics of the mains network suitable for performance analysis by simulation. This paper presents the impact of load impedances connected on the electrical network on insertion gain and capacity of the PLC link.
Adaptation of Tobacco Cells to NaCl.

Cell lines of tobacco (Nicotiana tabacum L. var Wisconsin 38) were obtained which are adapted to grow in media with varying concentrations of NaCl, up to 35 grams per liter (599 millimolar). Salt-adapted cells exhibited enhanced abilities to gain both fresh and dry weight in the presence of NaCl compared to cells which were growing in medium without NaCl (unadapted cells). Tolerance of unadapted cells and cells adapted to 10 grams per liter NaCl was influenced by the stage of growth, with the highest degree of tolerance exhibited by cells in the exponential phase. Cell osmotic potential and turgor varied through the growth cycle of unadapted cells and cells at all levels of adaptation, with maximum turgor occurring at approximately the onset of exponential fresh weight accumulation.Adaptation to NaCl led to reduced cell expansion and fresh weight gain, while dry weight gain remained unaffected. This reduction in cell expansion was not due to failure of the cells to maintain turgor since cells adapted to NaCl underwent osmotic adjustment in excess of the change in water potential caused by the addition of NaCl to the medium. Tolerance of the adapted cells, as indicated by fresh or dry weight gain, did not increase proportionately with the increase in turgor. Adaptation of these glycophytic cells to NaCl appears to involve mechanisms which result in an altered relationship between turgor and cell expansion.
Making Parametric Portfolio Policies Work

The implementation of parametric portfolio policies as introduced by Brandt, Santa Clara and Valkanov (RFS 2009) may run into empirical problems. For example, expected utility based on monthly returns of S&P-500 data from 1995-2013 turns non-monotonic for moderate levels of (constant) risk aversion. We establish that in the leading case of constant relative risk aversion (CRRA) strong assumptions on the properties of the returns, the variables used to implement the parametric portfolio policy and the parameter space are necessary to obtain a well defined optimization problem. Without such refinements an interior maximum of the expected utility functional may not exist. We provide economic conditions on the domain and/or the utility functions that overcome such empirical problems and that guarantee the effectiveness of the approach. We illustrate the implications of our improvements by applying parametric portfolio policies to a large universe of stocks.
Can a Taylor rule better explain the Fed’s monetary policy through the 1920s and 1930s? A nonlinear cliometric analysis

Abstract This paper investigates whether a variant of a Taylor rule applied to historical monetary data of the interwar period is useful to gain a better understanding of the Fed’s conduct of monetary policy over the period 1920–1940. To this end, we considered a standard Taylor rule (using two drivers: output gap and inflation gap) and proxied them differently for robustness. Further, we extended this Taylor rule to a nonlinear framework while enabling its coefficient to be time-varying and to change with regard to the phases in business cycle, in order to better capture any further asymmetry in the data and the structural break induced by the Great Depression. Accordingly, we showed two important findings. First, the linearity hypothesis was rejected, and we found that an On/Off Taylor Rule is appropriate to reproduce the conduct of monetary policy during the interwar period more effectively (the activation of drivers only occurs per regime). Second, unlike Field [Field, A. 2015. “The Taylor Rule in the 1920s. ” Working Paper], we validated the use of a Taylor rule to explain the conduct of monetary policy in history more effectively. Consequently, this nonlinear Taylor rule specification provides interesting results for a better understanding of monetary regimes during the interwar period, and offers useful complements to narrative monetary history.
Strain Situation after Fixation of Three-Unit Ceramic Veneered Implant Superstructures

The passive fit of superstructures used in implant prosthodontics is affected by several variables. The objective of this study was to quantify the strain development in various fixed partial dentures (FPDs), both in the condition as cast and after ceramic veneering. Five different types of three-unit FPDs (cementable/repositioning technique impression; cementable/pick-up technique impression; screw-retained/plastic cylinder; screw-retained/gold cylinder; screw-retained/bonded) with 10 samples each, representing commonly used FPD-types, were investigated before and after ceramic veneering. Two ITI implants were anchored in a measurement model simulating a real-life patient situation and strain gauges were mounted close to the implants. The strain development was recorded during cement setting and screw fixation. For statistical analysis, multivariate two-sample tests were performed with the level of significance set at P = 0.1. All FPDs revealed measurable amounts of strain. Neither the impression technique nor the fabrication modes for conventional screw-retained FPDs had a significant influence on strain development. Ceramic veneering caused an increase in strain development for the conventional bridge types. Furthermore, cementing appears to be able to compensate fabrication inaccuracies better than screw retention. The lowest strains were found in FPDs bonded to gold cylinders on the measurement model for metal frames and ceramic-veneered FPDs. Conventional procedures are unable to produce superstructures with an absolute passive fit. The technique of bonding superstructures to prefabricated components in the oral cavity seems to compensate for various shortcomings in superstructure fabrication.
Developing a diagnosis-based severity classification system for use in emergency medical services for children.

OBJECTIVES Lack of adequate risk adjustment methodologies has hindered the progress of emergency medicine health services research. The authors hypothesized that a consensus-derived, diagnosis-based severity classification system (SCS) would be significantly associated with actual measures of emergency department (ED) resource use and could ultimately be used to examine severity-adjusted outcomes across patient populations. METHODS A panel of subject matter experts used consensus methods to assign severity scores (1 = lowest severity to 5 = highest severity) to 3,041 ED International Classifications of Diseases (ICD), 9th revision, diagnosis codes. SCS scores were assigned to ED visits using the visit diagnosis code with the highest severity. We tested the association between the SCS scores and measures of ED resource use in three data sets: the Pediatric Emergency Care Applied Research Network Core Data Project (PCDP), the National Hospital Ambulatory Medical Care Survey (NHAMCS), and the Connecticut state ED data set. RESULTS There was a significant association between the five-level SCS and all six measures of resource use: triage category, disposition, ED resource use, Current Procedural Terminology Evaluation and Management (CPT E&M) codes, ED length of stay, and ED charges within the three ED data sets. CONCLUSIONS The SCS demonstrates validity in its strong association with actual ED resource use. The use of readily available ICD-9 diagnosis codes makes the SCS useful as a risk adjustment tool for health services research.
Young Children with Behçet Disease Have More Intestinal Involvement

Objective: Gastrointestinal (GI) involvement in childhood Behçet disease (BD) is not well understood. We aimed to clarify the intestinal presentation in children with BD. Methods: Medical records of 85 children with recurrent oral ulcers between 1990 and 2010 at the National Taiwan University Hospital were reviewed retrospectively. Twenty of them who fulfilled the Mason and Barnes criteria for the diagnosis of childhood BD were enrolled. The clinical and laboratory characteristics were analyzed. Results: Among 20 patients, the median age at diagnosis was 13.2 years. The common presentations included oral ulcers (100%), genital ulcers (70%), skin lesions (65%), and GI symptoms (50%). Five of 10 patients with GI symptoms received endoscopic examinations and all had ulcers. Divided by the age of 10, patients younger than 10 years tended to have higher rates of GI symptoms initially and intestinal ulcers (P = 0.002 and 0.015, respectively). Platelet count was significantly lower in young patients (P = 0.0151). Patients without GI symptoms had higher rates of skin involvement than patients with GI symptoms (P = 0.019). Conclusions: Young children with BD tended to have more GI presentations. For children with BD younger than 10 years having GI symptoms, endoscopic examinations may be considered.
The automatic component of habit in health behavior: habit as cue-contingent automaticity.

OBJECTIVE Habit might be usefully characterized as a form of automaticity that involves the association of a cue and a response. Three studies examined habitual automaticity in regard to different aspects of the cue-response relationship characteristic of unhealthy and healthy habits. DESIGN, MAIN OUTCOME MEASURES, AND RESULTS In each study, habitual automaticity was assessed by the Self-Report Habit Index (SRHI). In Study 1 SRHI scores correlated with attentional bias to smoking cues in a Stroop task. Study 2 examined the ability of a habit cue to elicit an unwanted habit response. In a prospective field study, habitual automaticity in relation to smoking when drinking alcohol in a licensed public house (pub) predicted the likelihood of cigarette-related action slips 2 months later after smoking in pubs had become illegal. In Study 3 experimental group participants formed an implementation intention to floss in response to a specified situational cue. Habitual automaticity of dental flossing was rapidly enhanced compared to controls. CONCLUSION The studies provided three different demonstrations of the importance of cues in the automatic operation of habits. Habitual automaticity assessed by the SRHI captured aspects of a habit that go beyond mere frequency or consistency of the behavior.
CONFIDENCE IN BELIEFS AND RATIONAL DECISION MAKING

Abstract: The standard, Bayesian account of rational belief and decision is often argued to be unable to cope properly with severe uncertainty, of the sort ubiquitous in some areas of policy making. This paper tackles the question of what should replace it as a guide for rational decision making. It defends a recent proposal, which reserves a role for the decision maker’s confidence in beliefs. Beyond being able to cope with severe uncertainty, the account has strong normative credentials on the main fronts typically evoked as relevant for rational belief and decision. It fares particularly well, we argue, in comparison to other prominent non-Bayesian models in the literature.
Mid-Career Academic Women: Strategies, Choices and Motivation

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Becoming Purikyua: Building the lifestyle-text in Japanese girls’ franchises

ABSTRACT The didactic elements of Japanese children’s media texts have assumed new forms alongside recent developments in franchising strategies. This paper argues that space-based franchising in Purikyua, a popular girls’ transmedia text, exemplifies a trend towards creating Japanese girls’ texts that use participatory activities to create environments that emphasise the potentially accessible nature of idealised gendered and commercialised identities. The instructive elements of girls’ transmedia texts find their fullest realisation in the creation of text-based spaces where girls are encouraged to enter the text and practise a Purikyua lifestyle. This article analyses the structure of three such text-based spaces, outlining their role in building a media system that seeks to guide children’s movements through the spaces of contemporary Japan.