Miracle-dz/UniFAR-FTUs huggingface dataset:
Puberty and depression: the roles of age, pubertal status and pubertal timing

Background. Previous work has indicated that the 2[ratio ]1 female[ratio ]male sex ratio in unipolar depressive disorders does not emerge until some time between ages 10 and 15. Methods. Data from four annual waves of data collection from the Great Smoky Mountains Study (GSMS) involving children aged nine to 16 were employed. Results. Pubertal status better predicted the emergence of the expected sex ratio than did age. Only after the transition to mid-puberty (Tanner Stage III and above) were girls more likely than boys to be depressed. The timing of this transition had no effect on depression rates. Before Tanner Stage III, boys had higher rates of depression than girls, and the prevalence of depression appeared to fall in boys at an earlier pubertal stage than that at which it began to rise in girls. In addition, recent transition to Tanner Stage III or higher had a transient effect in reducing the prevalence of depression in boys. Conclusions. The period of emergence of increased risk for depression in adolescent girls appears to be a relatively sharply demarcated developmental transition occurring in mid-puberty. Previously reported effects of the timing of puberty (which have tended to be transient) appeared less important in increase of risk for depression than pubertal status.
Impact of Loci Nature on Estimating Recombination and Mutation Rates in Chlamydia trachomatis

The knowledge of the frequency and relative weight of mutation and recombination events in evolution is essential for understanding how microorganisms reach fitted phenotypes. Traditionally, these evolutionary parameters have been inferred by using data from multilocus sequence typing (MLST), which is known to have yielded conflicting results. In the near future, these estimations will certainly be performed by computational analyses of full-genome sequences. However, it is not known whether this approach will yield accurate results as bacterial genomes exhibit heterogeneous representation of loci categories, and it is not clear how loci nature impacts such estimations. Therefore, we assessed how mutation and recombination inferences are shaped by loci with different genetic features, using the bacterium Chlamydia trachomatis as the study model. We found that loci assigning a high number of alleles and positively selected genes yielded nonconvergent estimates and incongruent phylogenies and thus are more prone to confound algorithms. Unexpectedly, for the model under evaluation, housekeeping genes and noncoding regions shaped estimations in a similar manner, which points to a nonrandom role of the latter in C. trachomatis evolution. Although the present results relate to a specific bacterium, we speculate that microbe-specific genomic architectures (such as coding capacity, polymorphism dispersion, and fraction of positively selected loci) may differentially buffer the effect of the confounding factors when estimating recombination and mutation rates and, thus, influence the accuracy of using full-genome sequences for such purpose. This putative bias associated with in silico inferences should be taken into account when discussing the results obtained by the analyses of full-genome sequences, in which the “one size fits all” approach may not be applicable.
Consecutive salmonella outbreaks traced to the same bakery

SUMMARY Two consecutive community outbreaks of Salmonella enteritidis phage type 4 (PT4) traced to the same bakery occurred in Cardiff, Wales during August–September 1992. In the first outbreak, illness was associated with eating custard slices (odds ratio 23·8, 95% confidence interval 6·5–94·4, P < 0·0001), and in the second, with eating fresh cream cakes (odds ratio 15·8, 95% confidence interval 1·6–374, P = 0·004). Environmental investigations implicated cross-contamination during preparation of the cold-custard mix as the cause of the first outbreak, and inadequate cleaning and disinfection of nozzles used for piping cream in the second outbreak. S. enteritidis PT4 was isolated from fresh cream sponge cake retained by a case and from two fresh cream cakes and four environmental swabs obtained at the bakery. This incident illustrates the hazard of widespread environmental contamination with salmonella and the need for thorough environmental cleansing of any premises implicated in an outbreak of food poisoning.
Valuing diversity: helping medical students explore their attitudes and beliefs

The General Medical Council of the United Kingdom has defined a set of standards for doctors dealing with patients, including respecting the diversity of lifestyles and beliefs of patients. These have been incorporated into the Personal and Professional Development (PPD) course unit of the undergraduate medical curriculum at Leeds University. The objectives of PPD include helping students understand how age, gender, culture, sexuality and disability affect how events are experienced or perceived. In 2002 seminars were run on valuing diversity to encourage students to develop insight into and reflect on their own attitudes to diversity. The sessions were evaluated and assessed by means of student feedback and as part of a written PPD exercise. Students rated the sessions highly and appeared to learn a great deal about diversity including approaches to communication and breaking down stereotypes. Their evaluation will help to improve the course.
THE NORMAL CONDITION OF THE FETAL ELECTROCARDIOGRAM DURING LABOUR

A real‐time computer system was employed to monitor continuously the fetal electrocardiogram (ECG) during labour. Signals from a scalp electrode were amplified, filtered and passed through an interface system to a digital computer. From 110 patients studied, 37 were selected by rigid criteria which fulfilled a strict definition of normal fetal condition in labour and delivery. The mean values and the range of the various parameters of the fetal ECG complex were defined. As a large amount of data was generated by the system, a method was developed to display the short and long‐term dynamic behaviour of the fetal ECG during labour in the form of labour profiles. By further averaging of these labour profiles, the pattern of normal behaviour was established. Certain changes in the fetal ECG, previously thought to be characteristic of fetal distress, occurred in normal patients. The P‐R interval was up to 10 per cent shorter during contractions towards the end of labour and there was a long‐term trend towards the end of labour for the P‐R interval to fall by 7 per cent. The P wave amplitude fell by 30 per cent over the last hour. These trends were statistically significant. The QRS complex was found to lengthen slightly towards the end of labour, but the R‐T interval and ST segment displacement displayed no significant changes.
Drosophila Syncrip modulates the expression of mRNAs encoding key synaptic proteins required for morphology at the neuromuscular junction

Localized mRNA translation is thought to play a key role in synaptic plasticity, but the identity of the transcripts and the molecular mechanism underlying their function are still poorly understood. Here, we show that Syncrip, a regulator of localized translation in the Drosophila oocyte and a component of mammalian neuronal mRNA granules, is also expressed in the Drosophila larval neuromuscular junction, where it regulates synaptic growth. We use RNA-immunoprecipitation followed by high-throughput sequencing and qRT-PCR to show that Syncrip associates with a number of mRNAs encoding proteins with key synaptic functions, including msp-300, syd-1, neurexin-1, futsch, highwire, discs large, and α-spectrin. The protein levels of MSP-300, Discs large, and a number of others are significantly affected in syncrip null mutants. Furthermore, syncrip mutants show a reduction in MSP-300 protein levels and defects in muscle nuclear distribution characteristic of msp-300 mutants. Our results highlight a number of potential new players in localized translation during synaptic plasticity in the neuromuscular junction. We propose that Syncrip acts as a modulator of synaptic plasticity by regulating the translation of these key mRNAs encoding synaptic scaffolding proteins and other important components involved in synaptic growth and function.
Significance of Softmax-Based Features in Comparison to Distance Metric Learning-Based Features

End-to-end distance metric learning (DML) has been applied to obtain features useful in many computer vision tasks. However, these DML studies have not provided equitable comparisons between features extracted from DML-based networks and softmax-based networks. In this paper, we present objective comparisons between these two approaches under the same network architecture.
An Examination of Medical and Psychological Morbidity in Adolescent Males With Eating Disorders

The objective of this study was to examine the clinical profile of adolescent male patients presenting for eating disorder (ED) assessment over a 17-year period. A retrospective cohort study was completed. A total of 52 patients (8% of the total sample) were included in the study. The average age of patients was 14.7 years and the most common diagnosis observed was Eating Disorder Not Otherwise Specified (EDNOS). Rates of concurrent depression and anxiety were very high, as were rates of medical co-morbidity, including osteoporosis. Our study supports findings documented in previously published reports of males with eating disorders and adds to the limited knowledge base which targets adolescents specifically. Multi-center controlled trials are required to further investigate male-specific ED symptomatology, treatment courses, and outcomes.
The pediatric hydroxyurea phase III clinical trial (BABY HUG): Challenges of study design

Evidence of the laboratory benefits of hydroxyurea and its clinical efficacy in reducing acute vaso‐occlusive events in adults and children with sickle cell anemia has accumulated for more than 15 years. A definitive clinical trial showing that hydroxyurea can also prevent organ damage might support widespread use of the drug at an early age. BABY HUG is a randomized, double‐blind placebo‐controlled trial to test whether treating young children ages 9–17 months at entry with a liquid preparation of hydroxyurea (20 mg/kg/day for 2 years) can decrease organ damage in the kidneys and spleen by at least 50%. Creation of BABY HUG entailed unique challenges and opportunities. Although protection of brain function might be considered a more compelling endpoint, preservation of spleen and renal function has clinical relevance, and significant treatment effects might be discernable within the mandated sample size of 200. Concerns about unanticipated severe toxicity and burdensome testing and monitoring requirements were addressed in part by an internal Feasibility and Safety Pilot Study, the successful completion of which was required prior to enrolling a larger number of children on the protocol. Concerns over recruitment of potentially vulnerable subjects were allayed by inclusion of a research subject advocate, or ombudsman. Finally, maintenance of blinding of research personnel was aided by inclusion of an unblinded primary endpoint person, charged with transmitting endpoint data and monitoring blood work locally for toxicity (ClinicalTrials.gov number, NCT00006400). Pediatr Blood Cancer 2010;54:250–255. © 2009 Wiley‐Liss, Inc.
Pre-aspiration and post-aspiration in Scottish Gaelic stop consonants

This paper aims to describe pre-aspirated and post-aspirated stops in an endangered language, Scottish Gaelic. Our small-scale study investigates several acoustic parameters of Scottish Gaelic stop consonants designed to measure the duration and noisiness of aspiration of the stop in its immediate phonetic context. Our study expands on previous phonetic descriptions of phonemic (pre-)aspiration in three ways: firstly, we provide a more complete durational description of Scottish Gaelic than previous work in the literature; secondly, we apply a new measure, band-pass filtered zero crossing rate (Gordeeva & Scobbie 2010), in order to examine the noisiness of aspiration in addition to durational characteristics. The results from this measure are presented in tandem with durational results in order to assess its usefulness for future research. Thirdly, we consider the possibility of change in the Scottish Gaelic stop system by examining data from older and younger speakers. Results suggest that band-pass filtered zero crossing rate is a useful tool and should be considered in future research on aspiration. Also, durational and zero crossing results indicate that younger speakers have shorter and less noisy pre-aspiration than older speakers. We discuss these results as a possible sound change in progress.
Heterobivalent ligands target cell-surface receptor combinations in vivo

A challenge in tumor targeting is to deliver payloads to cancers while sparing normal tissues. A limited number of antibodies appear to meet this challenge as therapeutics themselves or as drug-antibody conjugates. However, antibodies suffer from their large size, which can lead to unfavorable pharmacokinetics for some therapeutic payloads, and that they are targeted against only a single epitope, which can reduce their selectivity and specificity. Here, we propose an alternative targeting approach based on patterns of cell surface proteins to rationally develop small, synthetic heteromultivalent ligands (htMVLs) that target multiple receptors simultaneously. To gain insight into the multivalent ligand strategy in vivo, we have generated synthetic htMVLs that contain melanocortin (MSH) and cholecystokinin (CCK) pharmacophores that are connected via a fluorescent labeled, rationally designed synthetic linker. These ligands were tested in an experimental animal model containing tumors that expressed only one (control) or both (target) MSH and CCK receptors. After systemic injection of the htMVL in tumor-bearing mice, label was highly retained in tumors that expressed both, compared with one, target receptors. Selectivity was quantified by using ex vivo measurement of Europium-labeled htMVL, which had up to 12-fold higher specificity for dual compared with single receptor expressing cells. This proof-of-principle study provides in vivo evidence that small, rationally designed bivalent htMVLs can be used to selectively target cells that express both, compared with single complimentary cell surface targets. These data open the possibility that specific combinations of targets on tumors can be identified and selectively targeted using htMVLs.
Neural Stem Cells and Fetal-Onset Hydrocephalus

Fetal-onset hydrocephalus is not only a disorder of cerebrospinal fluid (CSF) dynamics, but also a brain disorder. How can we explain the inborn and, so far, irreparable neurological impairment in children born with hydrocephalus? We hypothesize that a cell junction pathology of neural stem cells (NSC) leads to two inseparable phenomena: hydrocephalus and abnormal neurogenesis. All neurons, glial cells, and ependymal cells of the mammalian central nervous system originate from the NSC forming the ventricular zone (VZ) and the neural progenitor cells (NPC) forming the subventricular zone. Several genetic mutations and certain foreign signals all convey into a final common pathway leading to cell junction pathology of NSC and VZ disruption. VZ disruption follows a temporal and spatial pattern; it leads to aqueduct obliteration and hydrocephalus in the cerebral aqueduct, while it results in abnormal neurogenesis in the telencephalon. The disrupted NSC and NPC are released into the CSF and may transform into neurospheres displaying a junctional pathology similar to that of NSC of the disrupted VZ. These cells can then be utilized to investigate molecular alterations underlying the disease and open an avenue into possible NSC therapy.
Vocal tract filtering and sound radiation in a songbird

SUMMARY Bird vocalizations resonate as they propagate through a relatively long trachea and radiate out from the oral cavity. Several studies have described the dynamics with which birds actively vary beak gape while singing and it has been hypothesized that birds vary beak gape as a mechanism for varying vocal tract resonances. Nevertheless, few studies have attempted to quantify the effects of beak gape on vocal tract resonances. We replaced eastern towhee, Pipilo erythrophthalmus L. , syringes with a small speaker and obtained recordings of frequency sweeps while rotating each subject in a horizontal plane aligned with either the maxilla or mandible. We describe vocal tract resonances as well as how sound radiates as a function of beak gape. Results are inconsistent with the hypothesis that songbirds vary beak gape as a mechanism for `tracking' fundamental frequencies in vocalizations. Instead, decreases in beak gape seem to attenuate resonances that occur between ∼4 and 7.5 kHz. We propose that songbirds vary beak gape as a mechanism for excluding and/or concentrating energy within at least two distinct sound frequency channels.
Development of RNA profiling tools and the implementation in forensic casework

In this thesis we have explored the use of mRNA profiling applications as tools for human body fluids and organ tissue identification of biological material found on crime scenes. The chapters cover the developmental processes and validation aspects of two RT-PCR multiplex assays; one aiming at body fluids and skin, and the second identifying organ tissues. In addition, detailed information is provided on the analysis of mixed RNA profiles, interpretation guidelines necessary for the implementation of RNA profiling in forensic laboratory and the prevalence of specific cell types on public objects.
Development and quality evaluation of defatted groundnut and melon kernel flour based ethnic product "Robo"

This study was carried out to develop a pepper-spiced flour based ethnic product “Robo” from melon and groundnut kernel with the aim of determining its nutritional quality and acceptability. Functional properties of defatted flours of groundnut and melon kernels were also determined. Crude protein (39.17 - 39.93%) and crude fat (16.80 - 17.53%) were found in groundnut “Robo” while crude protein (40.30 41.80%) and crude fat (17.70 - 17.73%) were found in melon “Robo”. Pepper spiced “Robo” generally had higher fibre (7.70 - 8.00%) and ash (6.23 - 7.10%) content. Results indicate that pepper spiced “Robo” from groundnut and melon can be regarded as a nutritious snack as it contains appreciable amount of protein, fat, minerals and fibre, this could enhance the achievement of millennium development goals on nutrition in the ethnic locality. Sensory evaluation results indicate a better acceptance of pepper spiced “Robo” from groundnut based of taste, texture, crunchiness and overall acceptability. Defatted flours of groundnut and pepper were found to have high water absorption capacity (270.40 - 274.70%), oil absorption capacity (213.90 - 235.20%) and fat emulsion capacity (28.20 - 29.50%) which indicate their potential use in food formulation for bakery products where water and oil retention is critical.
Design and Test of a Small React‐and‐Wind MgB2 Double Pancake

In the framework of the project on development of an integrated system for the production of PET tracers based on a dry NbTi supraconducting cyclotron called Lotus, the CEA and SigmaPhi examine the possibility of replacing the NbTi by MgB2. The aim of this work is to develop design tools and technologies for dry MgB2 magnet winding by the react-and-wind process. To validate this work, two dry prototype magnets have been developed: a solenoid of 1 T and a double pancake. To test these prototypes in conditions close to the Lotus cyclotron, a dry test facility, previously developed, will be used up to 3 T. This paper presents the double pancake design, fabrication, instrumentation, and the first test. The critical current and the n-value of the double pancake have been measured and compared with the sample measurement.
A Novel Image Denoising Algorithm Based on Non-Uniform Triangular Partition and Interpolation

Distinguishing from the traditional denoising methods, this paper proposes a novel denoising algorithm according to the image-surface fitting after the Non-Uniform Triangular Partition. A given image can automatically be partitioned into different triangles with different dimensions and the bivariate polynomial is used to do the Optimal Quadratic Approximation to gray values of image in each sub-triangle. When the approximation error and bivariate polynomial are specified, a specific image partition result is obtained. The partitioning codes obtained can be used to reconstruct the original image. In general, the smallest the error, the better approximation effect is obtained. However, we should select a suitable error to get the best approximation to original image instead of the noised image. On the other hand, in order to avoid the triangle effect after denoising and obtain a better denoising result, the interpolation method is used before and after the denoising by Non-Uniform Triangular Partition. Experimental results show that this method can obtain a better denoising effect by comparing with other methods to some extend.
[Total cholesterol mediates the effect of ABO blood group on coronary heart disease].

OBJECTIVE To find a potential link among ABO blood group, lipid profiles and coronary artery disease (CAD) and to estimate the effect size of connection using mediation analysis model. METHODS A total of 898 consecutive patients undergoing coronary angiography were enrolled, and divided into CAD group and non-CAD group according to angiographic findings. According to ABO blood group, patients were divided into O blood group and non-O blood group, as well as A blood group and non-A blood group. Baseline characteristics among various groups were compared and the association of ABO blood group, CAD and lipid profile was explored. RESULTS Subjects of blood type A had higher concentration of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) compared with that of non-A type (TC: (4.43 ± 1.12) mmol/L vs. (4.18 ± 1.09) mmol/L, LDL-C: (2.79 ± 0.99) mmo/L vs. (2.59 ± 1.01) mmol/L, all P < 0.01). TC and LDL-C were significantly higher while high density lipoprotein cholesterol (HDL-C) and ApoA I levels were significantly lower in CAD group than in non-CAD group (TC: (4.36 ± 1.05) mmol/L vs. (4.13 ± 1.16) mmol/L, LDL-C: (2.61 ± 0.87) mmol/L vs. (2.47 ± 0.94) mmol/L; ApoA I: (1.38 ± 0.29) mmol/L vs. (1.45 ± 0.33) mmol/L; all P < 0.01). After adjustment for traditional cardiovascular risk factors, blood group A and TC remained significantly associated with the risk of CAD (OR = 1.88, 95% CI 1.280-2.774, P < 0.01; OR = 1.03, 95% CI 1.018-1.033, P < 0.01, respectively). Specially, mediation analysis indicated that 10.5% of the effect of A blood group on CAD was mediated by TC levels (P < 0.01). CONCLUSION Our data indicate that there is an association between ABO blood group, TC levels and risk of CAD. Around 10.5% of the effect of A blood group on CAD is mediated by TC levels.
Changes in equivalence judgments following verbal, perceptual, or functional practice conditions.

The performance of first-grade children on Bruner and Olver's equivalence task was assessed with regard to special verbal, perceptual, and functional practice conditions. Practice with verbally presented equivalence tasks resulted in more functional responses than did practice with perceptually or functionally presented items. Conversely, equivalence practice with the items presented perceptually or functionally resulted in greater increments in superordination than did verbal practice. This dissociation between syntactic and semantic groupings suggests that superordination is not necessarily an indicator of developmental progression. Also, the number of functional responses was dependent upon the content of the equivalence list.