Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase-Stabilized W-Band Planar Imaging System for Near-to-Far-Field Projection Based on Photonic Sensors

This letter presents a highly stabilized planar near-field imaging system for millimeter-wave antenna characterization based on dual electrooptic sensors. The issue of system instability, which often occurs in millimeter-wave sensing, is effectively eliminated by employing error correction techniques with field-calibrated probes. This technique compensates for the phase vibration of a radio frequency source by using an additional reference probe. Detailed stabilization techniques for the phase drift are discussed. A probe is also field-calibrated on the W-band so as to provide electric field imaging with the absolute value. W-band horn antenna characterization at 95 GHz is conducted, and the absolute field distribution is compared using the proposed system and a conventional electrical near-field system. A simulation is also conducted. The radiation far-field pattern and gain, calculated from the near-field measurements, are in good agreement with each other according to a comparison of these outcomes. Moreover, a back-projection algorithm with a far electric field as input is utilized to reconstruct the aperture fields of a horn antenna. Finally, a comparison between the measured and reconstructed near-field data with different distances between the probe and the horn antenna is made.
Individual and Collective Behaviors Within Gatherings, Demonstrations, and Riots

The life cycles of gatherings, demonstrations, and riots begin with an assembling phase and end with a dispersal phase. The three types of events are primarily distinguished by the form and content of individual and collective behaviors that occur in the interim phase when a number of people are in the same locale at the same time. We review the past 15 years’ research on behaviors in this phase. We first consider some elementary forms of collective behavior that frequently occur in all gatherings, demonstrations, and riots. We next examine more complex dimensions and forms of behavior within political, religious, and sport demonstrations. We then review research on the individual and aggregate violence against person, property, and property rights that distinguishes riots. Finally, we note some recurring patterns in the research on all three types of events, and we identify problems warranting further investigation.
Conceptualizing and Defining the Intention Construct for Future Physical Activity Research

Intention has been an extremely important concept in physical activity theory and research but is complicated by a double-barreled definition of a decision to perform physical activity and the commitment to enact that decision. We put forth the hypothesis that these separate meanings have different measurement requirements, are situated in distinctly different intention-based models, and show discrete findings when explaining physical activity motives.
Systematic review of success factors and barriers for software process improvement in global software development

Nowadays, many software development organisations are globalising their work throughout the world. The motivation behind the software globalisation is competitive advantage and business profits that it yields to an organisation. Besides, these organisations are facing various challenges due to the distributed nature of the software development. However, software process improvement (SPI) is one of the biggest issues in the domain of global software development (GSD). The aim of this research study is to identify success factors and barriers to assist GSD organisations for successful implementation of SPI program. Accordingly, a systematic literature review approach was adopted to identify the success factors and barriers. A total of nine success factors and six barriers were identified that could impact SPI. Using the criteria of the factors having a frequency >50% as critical, total four success factors were ranked as critical success factors, i.e. management commitment, staff involvement, allocated resources and pilot projects. Moreover, total four barriers were classified as critical barriers, i.e. lack of resources, inexperienced staff, organisational politics and time pressure.
Two‐year‐olds can socially learn to think divergently

This study aimed to discover whether 2-year-olds can socially learn to think divergently. Two-year-olds (N = 22) who saw an experimenter model a high level of divergent thinking on the Unusual Box Test (modelling 25 different actions, once each) went on to demonstrate a higher level of divergent thinking themselves than (N = 22) children who saw a low level of modelling (five different actions, once each), where divergent thinking was measured by the number of different actions children produced that had not been modelled by the experimenter. Additionally, all children in both High and Low Divergence conditions had higher divergent thinking than imitation scores, where imitation involved copying the experimenter's previous actions. This is the first experiment to show that 2-year-olds' divergent thinking can be increased, and that 2-year-olds do so by socially learning to think more divergently. Statement of contribution What is already known on this subject Recent research found that children as young as 1 year can think divergently, and that this is influenced by parents' own divergent thinking. What does this study add? This paper is important as it provides the first method to increase divergent thinking in toddlers. It also shows that social learning can directly affect individual learning processes, which suggests current theories of social and individual learning should be revised to be more iterative.
Dental Caries Susceptibility in Mice Is Closely Linked to the H-2 Region on Chromosome 17

The generation of dental caries in humans is thought to be regulated by many intrinsic and social factors. In this study, we examined the effect of MHC on susceptibility to dental caries in mice. The mean carious score of BALB.K/Ola, a H-2 congenic strain in which the H-2 region derived from C3H/HeJ (H-2k/k) is introduced into BALB/cJ (H-2d/d), was markedly reduced as compared with that of its recipient strain (BALB/cJ). Mating experiments confirmed a strong genetic linkage between H-2 haplotype and caries susceptibility. These results demonstrate that one of the genetic factors of the susceptibility in the mouse is mapped within the H-2 region. This finding of a host genetic factor influencing the generation of dental caries will help in developing clinical preventive strategies.
Single-Phase to Three-Phase Unified Power Quality Conditioner Applied in Single-Wire Earth Return Electric Power Distribution Grids

This paper deals with the deployment of a local three-phase four-wire (3P4W) electrical power distribution system (EPDS), using a single- to three-phase unified power quality conditioner (UPQC) topology, called UPQC-1Ph-to-3Ph. The topology is indicated for applications in rural or remote areas in which, for economic reasons, only EPDS with single-wire earth return are accessible to the consumer. Since the use of three-phase loads is increasing in these areas, access to a three-phase distribution system becomes preponderant. By adopting a dual compensation strategy, the proposed UPQC-1Ph-to-3Ph is able of draining from the single-phase electrical grid a sinusoidal current and in phase with the voltage, resulting high-power factor. Furthermore, the system is also able to suppress grid voltage harmonics, as well as to compensate for other disturbances, such as voltage sags. Thus, a 3P4W system with regulated, balanced, and sinusoidal voltages with low-harmonic contents is provided for single- and three-phase loads. An analysis of the power flow through the series and parallel converters is performed in order to aid the designing of the power converters. Experimental results are presented for validating the proposal, as well as evaluating the static and dynamic performances of the proposed topology.
Targeted therapy of human glioblastoma via delivery of a toxin through a peptide directed to cell surface nucleolin

Targeted anticancer therapies demand discovery of new cellular targets to be exploited for the delivery of toxic molecules and drugs. In this perspective, in the last few years, nucleolin has been identified as an interesting surface marker to be used for the therapy of glioblastoma. In this study, we investigated whether a synthetic antagonist of cell‐surface nucleolin known as N6L, previously reported to decrease both tumor growth and tumor angiogenesis in several cancer cell lines, including glioblastoma cells, as well as endothelial cells proliferation, could be exploited to deliver a protein toxin (saporin) to glioblastoma cells. The pseudopeptide N6L cross‐linked to saporin‐S6 induced internalization of the toxin inside glioblastoma cancer cells. Our results in vitro demonstrated the effectiveness of this conjugate in inducing cell death, with an ID50 four orders of magnitude lower than that observed for free N6L. Furthermore, the preliminary in vivo study demonstrated efficiency in reducing the tumor mass in an orthotopic mouse model of glioblastoma.
Constellations of Dyadic Relationship Quality in Stepfamilies: A Factor Mixture Model

Stepfamilies are an increasingly common family form, marked by distinct challenges, opportunities, and complex networks of dyadic relationships that can transcend single households. There exists a dearth of typological analyses by which constellations of dyadic processes in stepfamilies are holistically analyzed. Factor mixture modeling is used to identify population heterogeneity with respect to features of mother–child, stepfather–child, nonresident father–child, and stepcouple relationships using a representative sample of 1,182 adolescents in mother–stepfather families with living nonresident fathers from Wave I of the National Longitudinal Study of Adolescent to Adult Health. Results favor a 4-class factor-mixture solution with class-specific factor covariance matrices. Class 1 (n = 302, 25.5%), the residence-centered pattern, was marked by high-quality residential relationships. Class 2 (n = 307, 26%), the inclusive pattern, was marked by high-quality relationships across all four dyads, with an especially involved nonresident father–child relationship. Class 3 (n = 350, 29.6%), the unhappy couple pattern, was marked by very low stepcouple relationship quality. Class 4 (n = 223, 18.9%), the parent–child disconnection pattern, was marked by distant relationships between youth and all three parental figures. The residence-centered and inclusive patterns encompassed some positive correlations between dyadic relationships whereas the unhappy couple and parent–child disconnection patterns encompassed some negative correlations between dyadic relationships. The patterns present with differences across sociodemographic and substantive covariates and highlight important opportunities for the development of new and innovative interventions, particularly to meet the needs of stepfamilies that reflect the parent–child disconnection pattern.
Experiences of Social Support Among Chinese Women with Breast Cancer: A Qualitative Analysis Using a Framework Approach

Background Breast cancer and its treatment provoke a series of emotional changes in patients during their breast cancer journeys. Social support is critical in helping women cope with their negative emotional responses. However, few studies have described the experiences of women with breast cancer within the Chinese context. This qualitative study explored the experiences of Chinese women with breast cancer regarding social support. Material/Methods This qualitative study was based on constructivism epistemology. Chinese women with breast cancer were invited to interview between June and August 2016. Purposive sampling was used, and the women were recruited until data saturation was reached (n=25). Results We found that all participants expressed the importance of social support during their breast cancer journeys. The thematic framework of social support was identified, which included the following 4 interrelated themes: providers, types of support, outcomes of support, and challenges for care. Conclusions Social support is important in the health care of women living with breast cancer. Healthcare professionals should provide more individualized support and care to women during this vulnerable period.
A Developmental Cascade Model of Behavioral Sleep Problems and Emotional and Attentional Self-Regulation Across Early Childhood

This article documents the longitudinal and reciprocal relations among behavioral sleep problems and emotional and attentional self-regulation in a population sample of 4,109 children participating in Growing Up in Australia: The Longitudinal Study of Australian Children (LSAC)–Infant Cohort. Maternal reports of children’s sleep problems and self-regulation were collected at five time-points from infancy to 8–9 years of age. Longitudinal structural equation modeling supported a developmental cascade model in which sleep problems have a persistent negative effect on emotional regulation, which in turn contributes to ongoing sleep problems and poorer attentional regulation in children over time. Findings suggest that sleep behaviors are a key target for interventions that aim to improve children’s self-regulatory capacities.
AlM2B2 (M  =  Cr, Mn, Fe, Co, Ni): a group of nanolaminated materials

Combining theory with experiments, we study the phase stability, elastic properties, electronic structure and hardness of layered ternary borides AlCr2B2, AlMn2B2, AlFe2B2, AlCo2B2, and AlNi2B2. We find that the first three borides of this series are stable phases, while AlCo2B2 and AlNi2B2 are metastable. We show that the elasticity increases in the boride series, and predict that AlCr2B2, AlMn2B2, and AlFe2B2 are more brittle, while AlCo2B2 and AlNi2B2 are more ductile. We propose that the elasticity of AlFe2B2 can be improved by alloying it with cobalt or nickel, or a combination of them. We present evidence that these ternary borides represent nanolaminated systems. Based on SEM measurements, we demonstrate that they exhibit the delamination phenomena, which leads to a reduced hardness compared to transition metal mono- and diborides. We discuss the background of delamination by analyzing chemical bonding and theoretical work of separation in these borides.
Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells

ABSTRACT Tumor necrosis factor (TNF)/TNF receptor (TNFR) superfamily members play essential roles in the development of the different phases of the immune response. Mouse LIGHT (TNFSF14) is a type II transmembrane protein with a C-terminus extracellular TNF homology domain (THD) that assembles in homotrimers and regulates the course of the immune responses by signaling through 2 receptors, the herpes virus entry mediator (HVEM, TNFSFR14) and the lymphotoxin β receptor (LTβR, TNFSFR3). LIGHT is a membrane-bound protein transiently expressed on activated T cells, natural killer (NK) cells and immature dendritic cells that can be proteolytically cleaved by a metalloprotease and released to the extracellular milieu. The immunotherapeutic potential of LIGHT blockade was evaluated in vivo. Administration of an antagonist of LIGHT interaction with its receptors attenuated the course of graft-versus-host reaction and recapitulated the reduced cytotoxic activity of LIGHT-deficient T cells adoptively transferred into non-irradiated semiallogeneic recipients. The lack of LIGHT expression on donor T cells or blockade of LIGHT interaction with its receptors slowed down the rate of T cell proliferation and decreased the frequency of precursor alloreactive T cells, retarding T cell differentiation toward effector T cells. The blockade of LIGHT/LTβR/HVEM pathway was associated with delayed downregulation of interleukin-7Rα and delayed upregulation of inducible costimulatory molecule expression on donor alloreactive CD8 T cells that are typical features of impaired T cell differentiation. These results expose the relevance of LIGHT/LTβR/HVEM interaction for the potential therapeutic control of the allogeneic immune responses mediated by alloreactive CD8 T cells that can contribute to prolong allograft survival.
Work-related stress in midlife and all-cause mortality: can sense of coherence modify this association?

BACKGROUND Survival reflects the accumulation of multiple influences experienced over the life course. Given the amount of time usually spent at work, the influence of work may be particularly important. We examined the association between work-related stress in midlife and subsequent mortality, investigating whether sense of coherence modified the association. METHODS Self-reported work-related stress was assessed in 1393 Swedish workers aged 42-65 who participated in the nationally representative Level of Living Survey in 1991. An established psychosocial job exposure matrix was applied to measure occupation-based stress. Sense of coherence was measured as meaningfulness, manageability and comprehensibility. Mortality data were collected from the Swedish National Cause of Death Register. Data were analyzed with hazard regression with Gompertz distributed baseline intensity. RESULTS After adjustment for socioeconomic position, occupation-based high job strain was associated with higher mortality in the presence of a weak sense of coherence (HR, 3.15; 1.62-6.13), a result that was stronger in women (HR, 4.48; 1.64-12.26) than in men (HR, 2.90; 1.12-7.49). Self-reported passive jobs were associated with higher mortality in the presence of a weak sense of coherence in men (HR, 2.76; 1.16-6.59). The link between work stress and mortality was not significant in the presence of a strong sense of coherence, indicating that a strong sense of coherence buffered the negative effects of work-related stress on mortality. CONCLUSIONS Modifications to work environments that reduce work-related stress may contribute to better health and longer lives, especially in combination with promoting a sense of coherence among workers.
Necrosis in anti-SRP+ and anti-HMGCR+myopathies

Objective To characterize muscle fiber necrosis in immune-mediated necrotizing myopathies (IMNM) with anti–signal recognition particle (SRP) or anti–3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGCR) antibodies and to explore its underlying molecular immune mechanisms. Methods Muscle biopsies from patients with IMNM were analyzed and compared to biopsies from control patients with myositis. In addition to immunostaining and reverse transcription PCR on muscle samples, in vitro immunostaining on primary muscle cells was performed. Results Creatine kinase levels and muscle regeneration correlated with the proportion of necrotic fibers (r = 0.6, p < 0.001). CD68+iNOS+ macrophages and a Th-1 immune environment were chiefly involved in ongoing myophagocytosis of necrotic fibers. T-cell densities correlated with necrosis but no signs of cytotoxicity were detected. Activation of the classical pathway of the complement cascade, accompanied by deposition of sarcolemmal immunoglobulins, featured involvement of humoral immunity. Presence of SRP and HMGCR proteins on altered myofibers was reproduced on myotubes exposed to purified patient-derived autoantibodies. Finally, a correlation between sarcolemmal complement deposits and fiber necrosis was observed (r = 0.4 and p = 0.004). Based on these observations, we propose to update the pathologic criteria of IMNM. Conclusion These data further corroborate the pathogenic role of anti-SRP and anti-HMGCR autoantibodies in IMNM, highlighting humoral mechanisms as key players in immunity and myofiber necrosis.
Host defenses in the neonate: prospects for enhancement.

Abstract The phagocytes won't eat microbes unless the microbes are nicely buttered for them. Well, the patient manufactures the butter for himself all right; but my discovery is that the manufacture of that butter, which I call opsonin, goes in the system by ups and downs. There is at bottom only one genuinely scientific treatment for all diseases, and that is to stimulate the phagocytes .
Callus induction and somatic embryogenesis in Stevia rebaudiana Bertoni as a medicinal plant.

Stevia rebaudiana (Bert.) from Asteraceae family is a useful medicinal plant that prevents and cures diabetes, blood pressure, weight gain and tooth decay. Due to self-incompatibility in stevia, somatic embryo investigation for artificial seed production is valuable in this plant. In order to evaluate the callus induction characteristics in stevia, a factorial experiment was laid out based on a completely randomized design with three replications. The factors included ten hormone combinations and control, two kinds of media (MS and B5) and two types of explants (leaf and internode). Callus induction characters including the percentage of callus formation, days to callus induction, fresh and dry callus weight were recorded. Analysis of variance showed significant differences (p<0.01) among hormone combinations, media and explant types as well as their interactions. The best treatment for callus induction with minimum time to callus formation was 1 mg/l NAA+1 mg/l BAP. The highest fresh and dry callus weight were obtained on B5 medium supplemented by 1 mg/l 2,4-D+1 mg/l BAP (in leaf explant) and 0.25 mg/l 2,4-D+ 0.1 mg/l BAP (in internode explant). These results can be used in suspension culture. To induce somatic embryogenesis in suspension culture, six hormone treatments were investigated. The highest somatic embryogenesis percentage was obtained in MS medium supplemented by 2 mg/l 2,4-D+ 0.5 mg/l NAA+0.5 mg/l BAP.
Prevalence of Psychotropic Medication Use Among Dutch Military Personnel Between 2003 and 2012 and Its Comparison to the Dutch General Population.

BACKGROUND The armed forces work under high pressure and in stressful environments and it is well known that being in the military is a risk factor for psychiatric problems. However, it remains unknown how prevalent psychotropic medication use is in military personnel. OBJECTIVE To assess prevalence of psychotropic medication use in Dutch military personnel and compare to the Dutch general population. METHODS Data were obtained from the military pharmacy. From 2003 to 2012, the year-prevalence of psychotropic medication use was calculated from the number of distributed psychotropic medications and the number of Dutch military personnel. For the year 2011, the year-prevalence of psychotropic medication use in the military was compared to that of the Dutch general population. RESULTS The year-prevalence of psychotropic medication use increased by 55%, from 1.64% in 2003 to 2.54% in 2012 in Dutch military personnel. An increase is seen in the number of users of psychotropic medication. Also the use of antidepressants and attention deficit hyperactivity disorder medication increased. CONCLUSION Over the last decade, there has been a 1.5-fold increase in psychotropic medication dispensed to Dutch military personnel. However, Dutch military personnel were significantly less likely to use psychotropic medications compared to the Dutch general population.