Miracle-dz/UniFAR-FTUs huggingface dataset:
Cancer Precision Medicine: Physiological Function of C-MYC as Targeted Molecule

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by /4.0) ABSTRACT The genome represents a design for creating the body, with each one being different. In cancer genomic medicine, many genes are simultaneously examined using mainly cancer tissues (the oncogene panel test), and gene mutations are revealed. Cancer treatments are then initiated according to each individual’s constitution and medical condition based on gene mutations. A system for cancer genome medical treatment is currently being developed. In the treatment of several cancer types, the “oncogene test with an oncogene companion diagnosis” is already being performed as a standard test using cancer tissue to detect one or several gene mutations. Precision Medicine: discovering unique therapies that treat an individual’s cancer based on the specific abnormalities, i.e. germline or somatic mutations of their tumors. In this paper, we will explain the biological role of C-MYC and emphasize the importance of C-MYC as a target factor in cancer precision medicine. The functional activated C-MYC for cell proliferation and tumorigenesis is potential candidate as anti-oncogenic molecule.
Effect of Processing Parameters on Proteolysis during ripening in Cheddar cheese

Proteolysis in Cheddar cheese, caused by various proteolytic enzymes present in cheese system, results in production of the smaller peptides. The current research was conducted to study the effect of heating temperature (72°C, 75°C, 78°C/15 second) and level of salting (1%, 1.5%, 2%) on proteolysis in Cheddar cheese during ripening. The extent of proteolysis was measured quantitatively by soluble protein content and qualitatively by the urea-PAGE throughout the four months of ripening. During ripening, an increase was found in the soluble protein content. The urea-PAGE had shown the degradation of β--casein and s1-casein to smaller fraction of γ-caseins and proteose-peptones. The highest soluble protein content (21.74 %w/w) was found in sample with 75°C/15 second heat treatment and 2% salt content at the 4 month of ripening. The effect of heat treatment and level of salting was not reflected in ureaPAGE, but it had shown the clear picture of degradation of native caseins to peptides during ripening.
Improvement of soil properties and plant responses by compost generated from biomass of phytoremediation plant

Phytoremediation is an emerging green technology that uses plants to remediate environments contaminated with toxic materials. However, plants used for phytoremediation in the leachate channel of a sanitary landfill must be harvested and recycled to prevent re-release of contaminants during decomposition. Therefore, experiments were conducted to test the use of the harvested remediation macrophytes, Phragmites australis and Typha angustifolia, as composting material. Compost produced from these macrophytes significantly improved soil conditions, and, for plants grown in soil with macrophyte compost, their performance improved based on chlorophyll contents, a stress evaluation, and increase in biomass. Additionally, the bioaccumulation of contaminants was not high, with the concentrations of some elements even lower than those in the control. The decomposition rate of macrophytes in the semiarid condition of the landfill was slow, but, once composted, plant biomass was more applicable to soil. This macrophyte compost can then also be used as an economical substitute for the commercial barks currently used as co-composting material. Therefore, the composting of remediation macrophytes from the leachate channel of a sanitary landfill for application to soil will help in the sustainable management of both the leachate channels and the soils on the slopes.
Perceived barriers to physical activity among women with arthritis

Arthritis is one of the most prevalent and debilitating chronic health conditions for Americans. As no cure exists for arthritis, one emphasis of treatment focuses on the selfmanagement of the disease through regular physical activity. Despite the well known health benefits, low physical activity rates exist among people with arthritis, particularly women. Research needs to focus on what influences decisions to participate in physical activity, one such influence is barriers. The purpose of the study was to examine the relationships among perceived barrier presence and perceived barrier limitation of 25 general and 16 arthritisspecific barriers and moderate physical activity. Participants were 279 women (Mage = 48.57) with arthritis who completed a web-based survey. A hierarchical multiple regression to predict moderate physical activity was significant (p < .001). General barrier limitation contributed the most to predicting total moderate physical activity participation. Education, body mass index, general barrier presence, arthritis-specific barrier presence, and arthritisspecific barrier limitations were also significant independent predictors. Findings suggest that the more general and arthritis-specific barriers identified (barrier presence) and higher extent of limitation (barrier limitation) was associated with lower levels of participation in physical activity. Future research would benefit from including a measurement of frequency of perceived barriers to better understand the impact of barriers to physical activity. A greater understanding of general and arthritis-specific barriers to physical activity may be used as a basis for targeted interventions to help women with arthritis participate in physical activity.
The Effect of Follicular Fluid on the Proliferation and Osteoblastic Differentiation of Human Bone Marrow Mesenchymal Stem Cells

Background and Aims: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are a well-known source of multipotent adult stem cells. Despite using different methodologies of MSCs preparing for clinical applications, the top safest procedure to manipulate these cells, has not yet been determined. Recently, ex-vivo expansion of MSCs for their subsequent implantation, using some biological product, is suggested instead of fetal bovine serum (FBS). Previous studies have shown the effect of follicular fluid (FF) (a dynamic fluid in ovarian follicle) as an additive component in cell culture. Hence, this study aimed to decipher its role on the human BM-MSC proliferation.Materials and Methods: In this study, BM-MSCs at 3rd passage were cultivated in the presence of 20% FF (group I), 10% FF+ FBS 10% (group II) and FBS 20% as control group. The capacity of proliferation as calculating population doubling times and gene expression levels of stem cell factor, stromal cell-derived factor 1, and transforming growth factor beta were analyzed in osteogeneic media to examine the impacts of FF on osteogenesis of MSCs.Results: Our results corroborated an up-regulatory effect of FF on the proliferation of BM-MSCs by shorter population doubling times in the group II of treated cells and an increase in gene expression level of osteocalcin and transforming growth factor beta in the presence of higher concentrations of FF in cell culture FF 20% and 10%, respectively.Conclusions: FF is a potent mitogen for cell proliferation. FF may be an efficient substitution of FBS in ex-vivo cell culture, eliminating zoonotic infections and immunological reactions.
Effect of conditioner and moisture content on flowability of yellow cornmeal

Abstract Flow characterization of ground materials based on standard physical properties is not always accurate and must be complemented with other properties that help characterize their flowability. The flow properties of yellow cornmeal as a function of moisture content (10.0%, 13.5% 17.0%, and 20.0% wet basis) and concentrations of added conditioner (calcium stearate, a caking agent classified at GRAS, at 0.50%, 0.75%, and 1.00% wt/wt) were measured. The optimum flow behavior characteristics of the cornmeal were achieved at 0.50% wt/wt calcium stearate and 10.0% (w.b.) moisture content based on the flow function test. Overall, the material's flowability decreased with increased moisture content based on very high values for Hausner's ratio, Carr's Index, and angle of repose. The flow index (ffc) obtained by the flow function test decreased from 6.47 to 3.82 as moisture increased, indicating increased cohesivity. Calcium stearate increased the flowability of the material at 0.50% wt/wt, beyond which the flowability was not affected (p > .05). Samples were very hygroscopic and classified as Class IV. The Hausner's ratio, Carr's Index, and angle of repose showed a strong linear relationship with the flow index with correlation values of 0.91, 0.88, and 0.88, respectively. Isotherms together with physical properties should be used to determine the flow characteristics of granulated materials such as yellow cornmeal to establish the best storage and processing conditions.
Effects of the Ethanolic Extracts of Guava Leaves, Licorice Roots and Cloves on the Cariogenic Properties of Streptococcus mutans

Dental caries (tooth decay) is an important oral infection, which is commonly found in people at any age. In Thailand, the incidence of dental caries was reported at 66-90% in 2007.1 Although many types of bacteria are found to be involved in the etiology of dental caries, Streptococcus mutans, gram-positive acid-producing cocci, is a major causative agent of dental caries in humans.2 The virulence of S. mutans involves its crucial cariogenic properties, including biofilm formation, surface adherence and acid production. The formation of bacterial biofilm or dental plaque on the tooth surface plays an important role in the pathogenesis of dental caries. The biofilm-forming bacteria can metabolize fermentable carbohydrates, especially sucrose into acid, which aggressively dissolve the mineral components of tooth structure. These lead to tooth demineralization, which subsequently results in dental caries. Dental caries can be treated by using several dental procedures, including tooth filling, root canal treatment and antibacterial therapy. Nonetheless, these methods need to be performed exclusively by the dentist. The preventions of dental caries by tooth brushing and using mouthwash and dental floss, are thus the better strategy to tackle dental caries. Some chemicals such as chlorhexidine and triclosan, are used in oral health-care products to eradicate acid-producing bacteria and prevent dental caries. However, there are some limitations of these agents such as tooth discoloration, oral and gastrointestinal irritations, and taste disturbance. The overuse of these substances may also destroy the normal flora and give rise to superinfection and antibacterial resistance.3 Therefore, using herbal products with anti-cariogenic activity is an interesting alternative for the prevention of dental caries.
Large Variation in Temperature Dependence of Band-to-Band Tunneling Current in Tunnel Devices

The observation of a significant temperature-dependent variation in the <inline-formula> <tex-math notation="LaTeX">${I}$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">${V}$ </tex-math></inline-formula> characteristics of tunneling devices is often interpreted as a signature of a trap-assisted-tunneling dominated current. In this letter, we use a ballistic 2D quantum-mechanical simulator, calibrated using the measured temperature-dependent <inline-formula> <tex-math notation="LaTeX">${I}$ </tex-math></inline-formula>–<inline-formula> <tex-math notation="LaTeX">${V}$ </tex-math></inline-formula> characteristics of Esaki diodes, to demonstrate that the temperature dependence of band-to-band tunneling (BTBT) current can vary significantly in both Esaki diodes and tunnel FETs. The variation of BTBT current with temperature is impacted by doping concentration, gate voltage, possible presence of a highly-doped pocket at the tunnel junction, and material.
Structure-property relationships in azobenzene-based twist-bend nematogens

ABSTRACT The synthesis and characterisation of a new set of azobenzene-based non-symmetric liquid crystal dimers, the 1-(4-substitutedazobenzene-4ʹ-yloxy)-6-(4-methoxybiphenyl-4ʹ-yl)hexanes (MeOB6OABX), that exhibit the twist-bend nematic phase, NTB, is described. The terminal substituents are methyl, methoxy, ethyl, butyl, butoxy, and nitrile. All six dimers exhibit both the NTB and conventional nematic, N, phases. The identification of the NTB phase was performed using polarised light microscopy and confirmed for binary mixtures with a standard twist-bend nematogen 1,7-bis-4-(4ʹ-cyanobiphenyl) heptane (CB7CB). The transitional behaviour of the MeOB6OABX dimers is compared with that of the corresponding ether-linked 1-(4-substitutedazobenzene-4ʹ-yloxy)-6-(4-methoxybiphenyl-4ʹ-yloxy)pentanes, MeOBO5OABX, all of which exhibit a conventional nematic phase. In addition, the nitrile-substituted MeOBO5OABCN shows the NTB phase. The behaviour of these non-symmetric dimers is also compared to that of the corresponding symmetric dimers. Differences in the transitional properties between these sets of new materials are accounted for in terms of not only molecular shape but also other factors including the strength of the mixed mesogen interaction. GRAPHICAL ABSTRACT
Diurnal and nocturnal cloud segmentation of all-sky imager (ASI) images using enhancement fully convolutional networks

Abstract. Cloud segmentation plays a very important role in astronomical observatory site selection. At present, few researchers segment cloud in nocturnal all-sky imager (ASI) images. This paper proposes a new automatic cloud segmentation algorithm that utilizes the advantages of deep-learning fully convolutional networks (FCNs) to segment cloud pixels from diurnal and nocturnal ASI images; it is called the enhancement fully convolutional network (EFCN). Firstly, all the ASI images in the data set from the Key Laboratory of Optical Astronomy at the National Astronomical Observatories of Chinese Academy of Sciences (CAS) are converted from the red–green–blue (RGB) color space to hue saturation intensity (HSI) color space. Secondly, the I channel of the HSI color space is enhanced by histogram equalization. Thirdly, all the ASI images are converted from the HSI color space to RGB color space. Then after 100 000 iterative trainings based on the ASI images in the training set, the optimum associated parameters of the EFCN-8s model are obtained. Finally, we use the trained EFCN-8s to segment the cloud pixels of the ASI image in the test set. In the experiments our proposed EFCN-8s was compared with four other algorithms (OTSU, FCN-8s, EFCN-32s, and EFCN-16s) using four evaluation metrics. Experiments show that the EFCN-8s is much more accurate in cloud segmentation for diurnal and nocturnal ASI images than the other four algorithms.
THE EFFECT OF GEL COMBINATION OF BINAHONG LEAF EXTRACT AND TURMERIC RHIZOME EXTRACT ON THE MATURE COLLAGEN DENSITY OF RATS WHICH HAVE II B DEGREE BURNS

The aim of this research was to study the effect of giving a combination gel of Binahong leaf extract and Turmeric rhizome extract on mature collagen which has II B degree burns. Twenty five male rats, 3 months of age, 150-200 gram body weight were used. This research consists of five treatments. T0 were normal skin, T1 were used 1% silver sulfadiazine, T2, T3, and T4 are gel combination of Binahong leaf extract and Turmeric rhizome extract with increase concentration of Binahong leaf extract i.e. 1.25%, 2.5%, and 5%, while the concentration of Turmeric rhizome extract i. e 2% for each treatment. Treatments have been given topically for 14 days, twice a day, started after burn wound application. At the end of the treatment period, skin excision was carried out, then the histopathological examination was performed. Microscopic observation on the wound healing process on mature collagen density showed that T0 was not a significant difference with T3 and T4 (p>0.05), but T0 was significant difference with T1 and T2 (p<0.05). The better burn healing process on T3 is allegedly because of the activity of saponin, and tannin, contained in the Binahong, and curcumin in Turmeric rhizome which has the function to stimulate collagen and make collagen mature early. The combination of Binahong leaf extract 2.5% and Turmeric rhizome extract 2% have been proven to be effective for topical burn therapy.
Effects of season, browse species and polyethylene glycol addition on in vitro degradability of forages in the sub-humid subtropical savannah, South Africa

Effects of season, browse species and polyethylene glycol (PEG) on in vitro digestibility of five plant species from sub-humid subtropical savannah of South Africa were investigated. Leaves of Acacia natalitia, Acacia nilotica, Dichrostachys cinerea, Scutia myrtina and Chromolaena odorata were harvested during dry (June/July), early wet (November/December) and late wet (February/March) seasons. An in vitro technique (72 h incubating time) was used in two experiments carried out with nine replicates (3 runs x 3 replicates). Experiment 1, tested the effects of season and browse species, while Experiment 2, tested the effect of condensed tannins using PEG (4000) on an in vitro degradability of the forages. Season and species affected the true degradability (TrDeg), short chain fatty acids (SCFA) and partitioning factor (PF). TrDeg ranged from 684 to 856 g/kg dry matter (DM). Total SCFA varied (P<0.05) among seasons and browse species. Addition of PEG decreased TrDeg and PF but increased total SCFA. Results suggested these browse species have potential to be used as feed supplements. Key words: Tannin-rich species, tannins, true degradability, short chain fatty acid.
The effect of sugar substitutes on selected characteristics of shortcrust pastry

The aim of this study was to evaluate the possibility of substituting sugar in crust pastry with natural substitutes, such as stevia, xylitol, coconut sugar as well as dried banana. Furthermore, a comparison of physicochemical properties was carried out. The crust pastry obtained was analyzed in terms of color by CIEL*a*b*, textures, water activity, bake loss, semi-consumer assessments and the nutritional value was calculated. There was a clear impact caused by the sugar substitute on the physicochemical properties and their sensory assessment. The cakes with xylitol had the closest color, smell and taste to the control sample (with sucrose). The cakes with dried banana had a significantly reduced hardness compared to the control sample. The lowest bake loss was observed in the case of pastry with dried banana, while the highest was in the case of xylitol. In sensory analysis, the “Just-about-right” method was used, and pastries with a sweter taste were more desirable (xylitol) and pastry with the stevia substitute showed the lowest desirability. The lowest energy value per 100 g was obtained for stevia (392 kcal/ 100g), while for xylitol energy, the value was reduced by 6%.
Injuries among professional soccer players of different age groups : a prospective four-year study in an English Premier League Football Club : research article

lIgBackground:l/Ig There are very few studies that compare the incidence and type of injuries in youth and senior elite soccer players with similar training and playing conditions over a sustained period of time. lbrglIgHypothesis:l/Ig The aim of this study was to investigate and compare the incidence and severity of injuries sustained by the senior and youth team soccer players at an English Premiership Football Club over four years. Study design:l/Ig Prospective and descriptive study. Data related to the occurrence, severity and location of injury, and how they affected participation in training and games, were collected for both groups over four years. lbrglIgMethods:l/Ig Injuries were prospectively recorded by the club's medical staff on a standardised database. Statistical analyses were performed with SPSS. lbrglIgResults:l/Ig There were 191 injuries in the senior team (85 players) and 236 in the youth team (112 players). All senior players sustained at least one recordable injury, compared with 110 injured players out of 112 in the youth team. The injury incidence during games was 23.2 injuries per 1000 hours in the senior team and 25.0 injuries per 1000 hours in the youth team, which was higher than that during training (4.2 injuries per 1000 training hours in senior team, 6.1 injuries per 1000 training hours in the youth team). There was no significant difference in absence per injury between the senior team (average 27.7 days) and the youth team (average 28.7 days). The knee (24%) and thigh (22%) represented the most common locations of injury in the senior team, whilst in the youth team the knee (19%) and ankle (19%) were most frequently injured. lbrglIgConclusions:l/Ig Although there is a slightly different injury pattern between senior and youth team players, the consequences for participation in training and games in the senior and youth team players of this English Premier Football Club are similar. Clinical relevance:l/Ig Youth team players are selected by Premier League Football Clubs with the ultimate aim to establish themselves in the first team squad. Injury, at such an important stage of their career development could significantly influence this progression.
Sensorineural Hearing Loss in Mucosal Type of Chronic Otitis Media

Sensorineural hearing loss as a complication of chronic suppurative otitis media is currently well established. However, most of the studies have been on patients with squamous otitis media as it is more prone for complications. Hence we have made an attempt to see (1) the occurrence of sensorineural hearing loss in mucosal type of chronic otitis media (2) the relation of sensorineural component with age of the patient, duration of the disease and (3) any special features of hearing loss. This is a cross sectional study done in Bangalore Medical College and Research Institute from June 2012 to May 2014. A total of 200 cases of mucosal type of chronic otitis media were studied. Their pure tone audiogram was assessed. Observation and results: Of the total 200 patients, 16 patients (8%) had sensorineural hearing loss. There were 11 males and 5 females in the group with a male to female ratio of 2.2: 1. The mean age was 34.75years with standard deviation (SD) being 9.08. It was found that the incidence of sensorineural hearing loss progressively increased with increasing duration of the disease. Mean bone conduction threshold of the diseased ear was 44.13 (standard deviation= 12.79) and in the control ear was 18.78 (standard deviation= 4.68). The sensorineural hearing loss was also noted to involve more of higher frequencies. The mean bone conduction (BC) threshold differences between the diseased and the control ears were 20.02 to 32.56 from 0.5 kHz to 4 kHz respectively. In the diseased ears, there were no significant correlation between the age and the degree of sensorineural hearing loss. Conclusions: Patients with mucosal type of chronic otitis media had a significant degree of sensorineural hearing loss in our study. The higher frequencies were more affected. The duration of the disease had an effect on the degree of sensorineural hearing loss but age factor did not have any significance.