Miracle-dz/UniFAR-FTUs huggingface dataset:
Complementary Medicine Use by Psychiatry Patients of an Australian Hospital

BACKGROUND: Complementary medicine (CM) usage continues to grow in popularity and is now widespread in many cultures throughout the world. Even so, detailed research addressing the use of many of these products in specific populations has yet to be undertaken. OBJECTIVE: To investigate CM usage among patients treated in an Australian psychiatry unit and to assess fundamental attitudes and beliefs regarding CM in this cohort. METHODS: Fifty-two patients were recruited from the department of psychiatry of an Australian teaching hospital. Forty-eight subjects were men, 4 were women, and the mean ± SD age of subjects was 56.7 ± 9.1 years. Structured interviews were conducted to obtain details of the extent of CM use, usage patterns, reasons for use, and general perceptions about CM. The questionnaire also elicited information about the subjects' past medical and psychiatric history, prescribed medication, and substance use. Satisfaction with conventional drugs and CMs was measured using visual analog scales. Responses to a series of structured statements were used to assess attitudes and beliefs about complementary therapies. RESULTS: Eighty-five CM treatments had been used by 27 (51.9%) subjects during the preceding 6 months, and 18 subjects were current CM users (44 items). The most common products taken were vitamins and minerals (n = 18) and herbal medicines (n = 14). Use of CM products was not related to demographic or medical factors, but was significantly less frequent among patients seeing their local physician >1 time per month. Only 17 of the respondents using CMs (63.0%) informed their physician about these therapies. Daily users of CMs ranked their satisfaction level with these products significantly higher (mean satisfaction score 79.0 ± 21.9) than with conventional therapies (62.9 ± 26.8). The attitude toward CMs was positive overall, and was slightly more favorable among users than nonusers. CONCLUSIONS: This survey provides insight into the nature of CM usage in an Australian population of psychiatry patients. As this and other studies have revealed extensive use of CM products in various populations, healthcare providers should take this into account and include this issue in discussions with patients.
Ultra-sensitive and responsive capacitive humidity sensor based on graphene oxide

Humidity sensors have attracted extensive attentions due to their various applications in environment monitoring, health care and internet of things. Graphene oxide has recently been exploited as a humidity sensing material because of its good hydrophilicity and excellent sensitivity. Here we report an ultra-sensitive and responsive capacitive humidity sensor using graphene oxide as sensing material. A capacitance change of ten times is observed when the relative humidity changes from 50% to 90%. The response and recovery time of the sensor are measured to be 0.066 and 0.154 s, respectively, which are several orders of magnitude shorter than conventional humidity sensors. Furthermore, its responses to flow rate, temperature and other vapors are also characterized.
Epidemiologic Evidence on Serum Adiponectin Level and Lipid Profile

The concentration of adiponectin, a hormone which is secreted from adipose tissue, is inversely correlated with body fat mass. This hormone has anti inflammatory and anti atherogenic properties. Its concentration reduces in metabolic syndrome and cardiovascular diseases. This study reviews the evidence on the relationship between serum adiponectin concentration and lipid profile. In this study former clinical trials, cross sectional and prospective studies have been reviewed. The PubMed search engine has been used to find related research for the topic by considering dyslipidemia, total cholesterol (TC), high and low density protein (HDL and LDL), triglyceride (TG), lipid profile (LP) and adiponectin as the key words. Finally, 25 articles were recruited to review in the present article. Serum adiponectin level was positively correlated with plasma HDL cholestrol concentrations. There was a significant inverse relationship between plasma triglyceride and serum adiponectin. An inverse correlation between very low density lipoprotein (VLDL) and LDL levels and adiponectin was reported from the studies. So, Adiponectin has an important role in the metabolism of lipid profile including HDLc.
Video Superresolution via Motion Compensation and Deep Residual Learning

Video superresolution (SR) techniques are of essential usages for high-resolution display devices due to the current lack of high-resolution videos. Although many algorithms have been proposed, video SR still remains a very challenging inverse problem under different conditions. In this paper, we propose a new method for video SR named motion compensation and residual net (MCResNet). We use optical flow algorithm for motion estimation and motion compensation as a preprocessing step. Then, we employ a novel deep residual convolutional neural network (CNN) to predict a high-resolution image using multiple motion compensated observations. The new residual CNN model preserves the low-frequency contents and facilitates the restoration of high-frequency details. Our method is able to handle large and complex motions adaptively. Extensive experimental results validate that our proposed method outperforms state-of-the-art single-image-based and multi-frame-based algorithms for video SR quantitatively and qualitatively.
A LASSO-Based Diagnostic Framework for Multivariate Statistical Process Control

In monitoring complex systems, apart from quick detection of abnormal changes of system performance and key parameters, accurate fault diagnosis of responsible factors has become increasingly critical in a variety of applications that involve rich process data. Conventional statistical process control (SPC) methods, such as interpretation and decomposition of Hotelling’s T2-type statistic, are often computationally expensive in such high-dimensional problems. In this article, we frame fault isolation as a two-sample variable selection problem to provide a unified diagnosis framework based on Bayesian information criterion (BIC). We propose a practical LASSO-based diagnostic procedure which combines BIC with the popular adaptive LASSO variable selection method. Given the oracle property of LASSO and its algorithm, the diagnostic result can be obtained easily and quickly with a similar computational effort as least squares regression. More importantly, the proposed method does not require making any extra tests that are necessary in existing diagnosis methods. Finally, we present several specific SPC examples, including multistage process control and profile monitoring, to demonstrate the effectiveness of our method. This article has supplementary material online.
Assessment of Tumor Vascularity in Lung Cancer Using Volume Perfusion CT (VPCT) With Histopathologic Comparison: A Further Step Toward an Individualized Tumor Characterization

Objective To measure perfusion in different lung cancer subtypes and compare results with histopathological/immunohistochemical results. Methods Seventy-two consecutive untreated patients with lung cancer (40 adenocarcinomas, 20 squamous cell, and 12 small cell lung cancers) were enrolled. A 40-second volume perfusion computed tomography of the tumor bulk was obtained. Blood flow (BF), blood volume (BV), and transit constant were determined. Tumor volume and tumor necrosis were determined on contrast-enhanced computed tomography. Pathologic specimens were assessed for microvessel density (MVD), hypoxia-induced transcription (hif-1/-2), and proliferation (Ki-67). Results Higher MVD is associated with higher BF and BV. Higher tumor grade leads to lower BF but increased necrosis and tumor volume. Markers of hypoxia were independent from perfusion parameters, extent of necrosis or MVD. Blood flow, BV, and MVD were not significantly different among lung cancer subtypes. Transit constant was significantly reduced in small cell lung cancer versus adenocarcinoma. Conclusions Perfusion values are related to MVD and tumor grade but vary considerably among lung cancer subtypes.
RENAL INFECTION IN PREGNANCY

SINCE Kass ( 1 955, 1956, 1957) defined the meaning of the three levels of bacteriuria which are now accepted there has been a great advance in the understanding of pyelonephritis. Much attention has been given to significant bacteriuria in the pregnant woman but little has been said about the progress of bacteriuria from lower levels in such patients. In this study a group of antenatal patients has been observed during the process of increasing bacteriuria, and from the detection of significant bacteriuria to the onset of clinical pyelonephritis. The main causative organisms have been identified. From consideration of these findings it is possible to outline a practical programme for the follow up of patients with doubtful levels of bacteriuria on initial examination.
Complete Genome Sequence of Lactobacillus casei LC5, a Potential Probiotics for Atopic Dermatitis

Probiotics are living microorganisms providing health beneficial effect to the host (1). Probiotics have been used for the treatment or prevention of various diseases related to diarrhea (2), cholesterol (3) immune function (4), and inflammatory bowel disease (5). In addition, recent study also presents that probiotic bacteria in the Bifidobacterium and Lactobacillus genera are able to have therapeutic effects in the patients of psychological disorders, such as depression, anxiety, and memory (6). Lactobacillus casei is a Gram-positive bacterium that naturally inhabits the human and animal gastrointestinal and mouth organs (7). As its name implies, this heterofermentative microorganism is the dominant species present in ripening cheddar cheese (8). In probiotic aspects, L. casei showed beneficial roles in the activation of the gut mucosal immune system (9), treatment of diabetics (10), and chronic constipation (11). In the previous study, we isolated L. casei LC5 strain from fermented dairy products, which showed immune regulatory functions, especially, therapeutic effect on atopic dermatitis as a member of complex probiotics (12–14). In order to gain better insight of the probiotic effect on atopic dermatitis, we analyzed the genome sequence of L. casei LC5. According to the report of NCBI Genome,1 more than two hundreds of Lactobacillus organisms are sequenced and their beneficial properties derived from genomic information are used in the food industry. However, the available genomes of L. casei strains as members of health promoting probiotics are still insufficient. Furthermore, L. casei strains are frequently confused with the closely related strains such as Lactobacillus paracasei and Lactobacillus rhamnosus. Therefore, comparative study in a whole genome scale is required to clarify taxonomic association of L. casei LC5 as well as its functional characteristics. The availability of the genomic information of L. casei LC5 will aid as a basis for further in-depth analysis of the probiotic function of L. casei strains.
Effects of Obesity and Smoking on Survival in Non-Small Cell Lung Cancer

Background: Obesity is an emerging leading cause of morbidity and mortality in the US and the relationship between obesity, tobacco, and survival in NSCLC is unclear. Methods: Data (n = 87,631) were obtained from linkage of the 1996-2007 Florida Cancer Data System to the Agency for Health Care Administration database providing procedure and diagnoses codes. Survival time was calculated from date of diagnosis to date of death. Smoking status was categorized as never, current, and former. Obesity (yes/no) = ICD9 code BMI > 30 kg/m2, cachexia = ICD9 code “wasting syndrome”, & non-obese = non-obese & non cachectic. Cox proportional regression models used to predict survival; demographic, clinical, treatment factors, & comorbidities were included in adjusted models with smoking status and obesity as the main factors. Results: The majority of patients (pts) were either former (49%) or current (40%) smokers, & non-obese (88%). 6.8% of pts were obese & 4.8% of pts were cachectic. There were significant differences between survival curves and median survival (months) for obese vs. non-obese vs. cachectic pts. (20 vs 10 vs. 7.9; P < 0.001). Former and current smokers had shorter median survival than never smokers (10.8 & 9.2 vs. 11.9; P < 0.001). Survival rates (%) at 1-yr (60.1 vs. 45.2 vs. 37.7; P < 0.001), 5-yr (30.3 vs. 15.4 vs. 9.5; P < 0.001), 10-yr (18.1 vs. 7.6 vs. 2.7; P < 0.001) were better for obese vs. non-obese and cachectic pts respectively. Independent predictor of worse survival in the unadjusted model was former (HR 1.08; P < 0.001) and current (HR 1.20; P < 0.001) smokers compared to never. Obese and non-obese pts had better survival vs. cachexia pts. (HR 0.52; P < 0.001 and HR 0.80, p < 0.001 respectively) and obese had better survival than Non-obese pts (HR 0.65, p < 0.001). In the adjusted model, controlling for extensive variables and comorbidities, former (HR 1.11; P < 0.001) and current (HR 1.19; P < 0.001) smokers still had significantly worse survival vs. never smokers. Obese patients still had better survival (HR 0.87; P < 0.001, and HR 0.88, p < 0.001) vs. cachexia patients and non-obese respectively, survival rate was not significantly different compare non-obese with cachexia. Conclusions: Our results show that being a former or current smoker worsens survival while obesity improved survival when compared with cachexia patients or Non-obese.
K4‐free and C6¯ ‐free Planar Matching Covered Graphs

A bi‐subdivision of a graph J is a graph H obtained from J by subdividing each of its edges by inserting an even number of vertices. A matching covered subgraph H of a matching covered graph G is conformal if G−V(H) has a perfect matching. Using the theory of ear decompositions, Lovász (Combinatorica, 3 (1983), 105–117) showed that every nonbipartite matching covered graph has a conformal subgraph which is either a bi‐subdivision of K4 or of C6¯ . (The graph C6¯ is the triangular prism.) A matching covered graph is K4‐based if it contains a bi‐subdivision of K4 as a conformal subgraph; otherwise it is K4‐free. C6¯ ‐based and C6¯ ‐free graphs are analogously defined. The result of Lovász quoted above implies that any nonbipartite matching covered graph is either K4‐based or C6¯ ‐based (or both). The problem of deciding which matching covered graphs are K4‐based and which are C6¯ ‐based is, in general, unsolved. In this paper, we present a solution to this classification problem in the special case of planar graphs. In Section 2, we show that a matching covered graph is K4‐free ( C6¯ ‐free) if and only if each of its bricks is K4‐free ( C6¯ ‐free). In Section 5, we show that a planar brick is K4‐free if and only if it has precisely two odd faces. In Section 6, we determine the list of all C6¯ ‐free planar bricks; apart from one exception, it consists of two infinite families of bricks. The principal tool we use for proving our results is the brick generation procedure established by Norine and Thomas (J Combin Theory Ser B, 97 (2007), 769–817).
Presence of a trs-Like Motif Promotes Rep-Mediated Wild-Type Adeno-Associated Virus Type 2 Integration

ABSTRACT High-throughput integration site (IS) analysis of wild-type adeno-associated virus type 2 (wtAAV2) in human dermal fibroblasts (HDFs) and HeLa cells revealed that juxtaposition of a Rep binding site (RBS) and terminal resolution site (trs)-like motif leads to a 4-fold-increased probability of wtAAV integration. Electrophoretic mobility shift assays (EMSAs) confirmed binding of Rep to off-target RBSs. For the first time, we show Rep protein off-target nicking activity, highlighting the importance of the nicking substrate for Rep-mediated integration.
Clinical Pharmacology of Topiramate: A Review

Clinical success with an antiepileptic drug (AED) depends primarily on its efficacy and tolerability. Clinicians also need to have a basic understanding of an AED's pharma‐cokinetic characteristics, particularly those affecting the potential for drug interactions such as hepatic enzyme inhibition or induction and protein‐binding displacement. Successful treatment may be complicated by pharmacokinetic characteristics such as a short half‐life, nonlinear kinetics, and active metabolites. Pharmacokinetic characteristics that make a drug easy to use may affect patient adherence. In general, newer AEDs such as topiramate (TPM) are simpler to use than traditional AEDs because they have more favorable pharmacokinetic characteristics and fewer drug interactions.
IL - 17 in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies and the formation of immune complexes that can damage multiple tissues, organs and systems. IL-17 is a proinflammatory cytokine that plays an important role in several autoimmune diseases including SLE. The expression of IL-17 is elevated in both SLE patients and in lupus-prone mice, and it is positively correlated with disease activity. IL-17 also appears to participate in the development of several SLE complications. In this article, we provide an overview and an update of the role of IL-17 in SLE.
Thermodynamic and kinetic properties of surface dislocations on Au(001) from atomistic simulations

We examined the thermodynamic and kinetic properties of surface dislocations on the Au 001 surface using atomistic simulations based on a modified embedded atom potential that was optimized for Au surfaces. Two different surface dislocations are obtained, containing five displaced atomic columns type I or three displaced atomic columns type II. Both configurations are more stable than adatoms on the surface and type I is more stable than type II surface dislocation. The energy of the surface containing type I surface dislocations decreases with decreasing dislocation spacing, while that containing type II surface dislocations exhibits a minimum at a particular dislocation spacing. The surface stress of surfaces with type I surface dislocations surprisingly increases with decreasing surface dislocation spacing, while the surface stress decreases with decreasing dislocation spacing on surfaces containing type II surface dislocations. We also calculated the activation energies for surface dislocation migration in directions perpendicular and parallel to the surface dislocation line using a string method. The activation energies of both perpendicular and parallel motions are similar, and therefore a surface dislocation can move both parallel and normal to itself. This has been confirmed experimentally. We also found that type II surface surface dislocation corresponds to a metastable structure through which the type I surface dislocation must pass as it migrates perpendicular to its line direction.
Temporal trends and geographic variations in surgical treatment of femoral neck fractures.

BACKGROUND The objectives of this study were to examine temporal trends in treatment of femoral neck fractures, factors associated with treatment, and variations in practice patterns among counties and hospitals in Ontario, Canada. METHODS Hospital discharge data were analyzed. Cases were defined as age > 50 years with a surgically treated femoral neck fracture between 1981 and 1992 (n = 29,391). RESULTS The age-adjusted and sex-adjusted proportion of patients treated with hemiarthroplasty (HA) increased from 45% in 1981 to 61% in 1992 (p < 0.0001). HA is more likely to be performed among women, older patients, and nursing home patients. Among counties there was a 38-fold variation for total hip arthroplasty (0.5-38%) and a 9-fold variation in use of HA (9-83%). The degree of variation in treatment was mainly the result of individual hospitals. CONCLUSION The wide regional variations in treatment of femoral neck fractures reflect a lack of consensus in Ontario.
MANDIBULAR GROWTH AND DENTAL OCCLUSION IN JUVENILE RHEUMATOID ARTHRITIS.

Summary and ConclusionsThe effect of juvenile rheumatoid arthritis on mandibular growth and the dental occlusion in nineteen patients at the Hospital for Rheumatic Diseases of the Oslo Women's Health Association were examined. When the tmj is involved insufficient condylar growth with subsequent reduction in the forward and downward displacement of the lower jaw is frequently seen.The growth deficiency is especially marked when the tmj is affected in the first years of life.Most cases reveal a posterior rotation of the lower jaw, with a short ascending ramus, an obtuse angle between the mandibular body and the ascending ramus, a moderate vertical height of the alveolar process in the molar region and a pronounced vertical height in the incisor region. A short and distally directed condylar neck is occasionally found.Subsequent changes in the dental occlusion are a tendency toward distocclusion and an anterior open bite.The micrognathia causes a decreased tongue space which is partly compensated for by an .
El Estado y la migración global colombiana

In less than two decades, the Colombian state’s position vis–a–vis its national population abroad has radically changed. this change includes the implementation of novel initiatives actively seeking to incorporate this population into the national project. these initiatives include several constitutional changes that grant a wide range of rights to Colombians residing abroad, such as the right to dual citizenship, voting from abroad, representation in the House of Representatives of the national Congress, and official programs that promote the active integration of migrants to the quotidian live of the country, such as the Ministry of Foreign Relations’ Colombia nos Une program and Conexion Colombia, a program cosponsored with the private sector. What factors have pushed the state to adopt this new and determined position in relation to its connationals abroad? Who are the migrants and how have they incorporated themselves abroad? these are some of the questions this essay tries to respond aiming at a better understanding of the Colombian migration process from a global perspective.
Attachment and ingestion of bacteria by trophozoites of Entamoeba histolytica

Entamoeba histolytica trophozoites were found to be very selective in their interactions with bacteria. Two principal mechanisms were shown to be responsible for these interactions. Certain bacteria, such as a number of Escherichia coli and Serratia marcescens strains which are known to contain mannose-binding components on their cell surface, bound to mannose receptors on the amoeba membrane. This attachment was markedly inhibited by alpha-methylmannoside (0.5%), especially when the incubations were done at low temperature (5 degrees C). Other bacterial species, such as Shigella flexneri and Staphylococcus aureus, which do not possess a mannose-binding capacity, attached to the amoebae, but only with the aid of concanavalin A or after opsonization of the bacteria with immune serum. In both types of attachment, between 40 and 100 bacteria bound per amoeba, and considerable ingestion of bacteria into amoeba vacuoles was observed at 37 degrees C. The attachment of opsonized bacteria to the amoebae does not appear to be mediated by Fc receptors since Fab' dimers obtained after pepsin digestion of immunoglobulin were capable of mediating adherence. Furthermore, preincubation of the amoebae with aggregated human immunoglobulin G or with heat-inactivated immune serum and EDTA did not inhibit the attachment of opsonized bacteria. The attachment of opsonized bacteria was markedly inhibited by N-acetylglucosamine-containing glycoconjugates, such as peptidoglycan and chitin oligosaccharides, as well as by N-acetylgalactosamine. These results indicate that amoebae can attach and ingest bacteria either by using their membrane-associated carbohydrate-binding protein or by having their mannose-containing cell surface components serve as receptors.