Miracle-dz/UniFAR-FTUs huggingface dataset:
Short- and Long-Term Outcome of Chronic Dialyzed Patients Admitted to the ICU and Assessment of Prognosis Factors: Results of a 6-Year Cohort Study.

OBJECTIVES Data about end-stage kidney disease patients admitted to the ICU are scarce, dated, and mostly limited to short-term survival. The aim of this study was to assess the short- and long-term outcome and to determine the prognostic factors for end-stage kidney disease patients admitted to the ICU. DESIGN Prospective observational study. SETTING Medical ICUs in two university hospitals. PATIENTS Consecutive end-stage kidney disease patients admitted in two ICUs between 2012 and 2017. INTERVENTION None. MEASUREMENTS AND MAIN RESULTS Renal replacement therapy variables, demographic, clinical, and biological data were collected. The requirement of mechanical ventilation and vasopressive drugs were also collected. In-ICU and one-year mortality were estimated and all data were analyzed in order to identify predictive factors of short and long-term mortality. A total of 140 patients were included, representing 1.7% of total admissions over the study period. Septic shock was the main reason for admission mostly of pulmonary origin. Median Simplified Acute Physiology Score II and Sequential Organ Failure Assessment score were at 63 and 6.7 respectively. In-ICU, hospital, and 1-year mortality were 41.4%, 46.4%, and 63%, respectively. ICU mortality was significantly higher as compared with ICU control group non-end-stage kidney disease (25% vs 41.4%; p = 0.005). By multivariate analysis, the short-term outcome was significantly associated with nonrenal Sequential Organ Failure Assessment score, and with the requirement of mechanical ventilation or/and vasoconstrictive agents during ICU stay. One-year mortality was associated with increased dialysis duration (> 3 yr) and phosphatemia (> 2.5 mmol/L), with lower albuminemia (< 30 g/L) and nonrenal Sequential Organ Failure Assessment greater than 8. CONCLUSIONS End-stage kidney disease patients presented frequently severe complications requiring critical care that induced significant short- and long-term mortality. ICU and hospital mortality depended mainly on the severity of the critical event reflected by Sequential Organ Failure Assessment score and the need of mechanical ventilation and/or catecholamines. One-year mortality was associated with both albuminemia and phosphatemia and with prior duration of chronic dialysis treatment, and with organ failure at ICU admission.
Ctp1CtIP and Rad32Mre11 Nuclease Activity Are Required for Rec12Spo11 Removal, but Rec12Spo11 Removal Is Dispensable for Other MRN-Dependent Meiotic Functions

ABSTRACT The evolutionarily conserved Mre11/Rad50/Nbs1 (MRN) complex is involved in various aspects of meiosis. Whereas available evidence suggests that the Mre11 nuclease activity might be responsible for Spo11 removal in Saccharomyces cerevisiae, this has not been confirmed experimentally. This study demonstrates for the first time that Mre11 (Schizosaccharomyces pombe Rad32Mre11) nuclease activity is required for the removal of Rec12Spo11. Furthermore, we show that the CtIP homologue Ctp1 is required for Rec12Spo11 removal, confirming functional conservation between Ctp1CtIP and the more distantly related Sae2 protein from Saccharomyces cerevisiae. Finally, we show that the MRN complex is required for meiotic recombination, chromatin remodeling at the ade6-M26 recombination hot spot, and formation of linear elements (which are the equivalent of the synaptonemal complex found in other eukaryotes) but that all of these functions are proficient in a rad50S mutant, which is deficient for Rec12Spo11 removal. These observations suggest that the conserved role of the MRN complex in these meiotic functions is independent of Rec12Spo11 removal.
UNITED STATES AIR FORCE RESEARCH LABORATORY ORGANIZATION AND COMPONENTS OF PSYCHOMOTOR ABILITY

from the journal article) 1 Organization and Components of Psychomotor Ability 2 Definition 2 What is known about psychomotor abilities? 2 The Latent-Structure Approach to Psychomotor Ability 3 Psychomotor Tasks and Fleishman's Taxonomy 3 Cognitive Ability 4 Time estimation • 4 Processing speed 5 Repeated testing 5 Method 5 Participants 5 Apparatus • 5 Procedure 6 General administration • • 6 Psychomotor tests: general 6 Psychomotor tests: Control Precision 7 Psychomotor tests: Multi-limb coordination 8 Psychomotor tests: Rate Control 10 Psychomotor tests: Response Orientation 11 Extended Practice • • 12 General intellectual ability 13 Specific information-processing battery 15 Results ' Descriptive Statistics on Tests • 16 Viability of Fleishman's Taxonomy 16 Learning Effects 18 Regression of Psychomotor on Cognitive Factors 19 Analysis of the Cognitive Variables Alone : 19 Forming Composites for Conducting the Regression Analysis 20 Psychomotor-on-Cognitive Regression Analysis 21 Varying the Identity of the Cognitive Factors 22 Varying the Identity of the Psychomotor Factors 22 One vs. Two Pass Estimates of Regression Coefficients 22 The Changing Nature of Psychomotor Ability with Practice 24 Discussion • 26 The Small Dimensionality of the Psychomotor Abilities Space 26 The role of g (or working memory) in psychomotor ability 27 The role of time estimation in psychomotor ability 28 Unique aspects of psychomotor ability 29 The changing nature of psychomotor skill with practice : 29 Future Research 29 References 30 Authors Note 33 Appendix Archival Tables (W1-W8) from the website archive 34
Can a Web-based food record accurately assess energy intake in overweight and obese women? A pilot study.

BACKGROUND Innovative dietary intake measurement tools, such as web-based food records, are becoming increasingly available for self-monitoring. However, the accuracy of this method has not been well studied. This pilot study aimed to evaluate the accuracy of energy intake (EI) estimated by a web-based food record, by comparison with total energy expenditure (TEE) measured by doubly-labelled water (DLW) in overweight and obese women. METHODS Total energy expenditure (TEE) was assessed in weight stable (±1 kg) women (n = 9), with a mean (SD) age of 34.5 (11.3) years and body mass index of 29.2 (1.4) kg m(-2) over 10 days using the DLW technique. All food and beverages were self-reported for 9-days using a web-based food record and mean daily EI calculated. Food record accuracy was assessed by calculating the absolute (EI - TEE) and percentage (EI/TEE × 100) differences between EI and TEE. Women were identified as under-reporters of EI based on the 95% confidence limits of the expected EI : TEE of 1. RESULTS The mean (SD) self-reported EI was 8351 (1225) kJ day(-1) [1996 (293) kcal day(-1) ] and TEE was 10 648 (1774) kJ day(-1) [2545 (424) kcal day(-1) ]. The mean (SD) absolute difference in self-reported EI and TEE was -2301 (1535) kJ day(-1) [-550 (367) kcal day(-1) ], representing a mean reporting accuracy of 79.6% (14.1%), with four participants under-reporting EI. CONCLUSIONS This pilot study highlights the opportunity for the use of the Internet as a novel medium for recording and assessing dietary intake. Although further research is needed in more diverse population groups, the accuracy of web-based food records for assessing EI appears to be consistent with other published dietary intake methods.
Space-Time block codes: A maximum SNR approach

In Tarokh et al. (1999) space-time block codes were introduced to obtain coded diversity for a multiple-antenna communication system, in this work, we cast space-time codes in an optimal signal-to-noise ratio (SNR) framework and show that they achieve the maximum SNR and, in fact, they correspond to a generalized maximal ratio combiner. The maximum SNR framework also helps in calculating the distribution of the SNR and in deriving explicit expressions for bit error rates. We bring out the connection between the theory of amicable orthogonal designs and space-time codes. Based on this, we give a much simpler proof to one of the main theorems on space-time codes for complex symbols. We present a rate 1/2 code for complex symbols which has a smaller delay than the code already known. We also present another rate 3/4 code which is simpler than the one already known, in the sense it does not involve additions or multiplications. We also point out the connection between generalized real designs and generalized orthogonal designs.
High resolution 1H‐n.m.r. study of the interaction between initiation factor IF1 and 30S ribosomal subunits.

Interaction between Escherichia coli translational initiation factor IF1 (mol. wt. 8119) and 30S ribosomal subunits was followed by high resolution 1H‐n.m. r. spectroscopy. Upon gradual addition of increasing yet largely sub‐stoichiometric amounts of biologically active deuterated 30S ribosomal subunits, selective line broadenings and chemical shift changes were observed against the background of the gradual disappearance of the whole spectrum. At the highest 30S:IF1 ratio attained (0.25), all the resonance lines were broadened beyond meaningful detection. This behaviour, which can be partly reversed by increasing the ionic strength and/or the temperature, is due to the interaction between IF1 and the 30S ribosomal subunits, and can be explained by the existence of a medium‐fast exchange dynamics between free and bound factor. The selective effects observed during titration with 30S ribosomal subunits shed some light on the mode of interaction of IF1 with 30S ribosomal subunits. At least one of the two His residues of the factor appears to be involved in the binding, since it undergoes a low‐field change of chemical shift and becomes totally immobilized in the IF1‐30S complex. Also strongly implicated in the interaction with 30S are more than one Ser and Arg residue and probably one lysine. Additional effects of the interaction of IF1 with ribosomes are a drastic reduction in the intensity of the ring current upfield shifted methyl resonances and mobilization of a previously rotationally hindered phenylalanine ring.
A Multiple Lender Approach to Understanding Supply and Search in the Equity Lending Market

Using unique data from 12 lenders, we examine how equity lending fees respond to demand shocks. We find that when demand is moderate, fees are largely insensitive to demand shocks. However, at high demand levels, further increases in demand lead to significantly higher fees and the extent to which demand shocks impact fees is also related to search frictions in the loan market. Moreover, consistent with search models, we find significant dispersion in loan fees, with this dispersion increasing in loan scarcity and search frictions. Our findings imply that search frictions significantly impact short selling costs.
Évaluation du Potentiel des Rapports Isotopiques Stables du Strontium et du Plomb pour l'Origine Géographique et l'Authenticité des Produits Alimentaires

L'authenticite et la tracabilite des aliments gagnent un interet croissant au cours de la derniere decennie puisque la connaissance de la provenance des aliments est consideree comme une garantie supplementaire de leur qualite. Les consommateurs ont egalement des inquietudes et des preoccupations par l'origine de la nourriture qu'ils consomment car divers produits sont sujets a l'adulteration ou a la fausse denomination. L'interet accru a l’egard de la protection des consommateurs et de la lutte antifraude ont entraine un accroissement de la recherche scientifique appliquee et le developpement d'outils efficaces pour controler l'authenticite des produits alimentaires. Entre techniques analytiques appliquees a l'authenticite et a la tracabilite des aliments, les methodes les plus prometteuses sont basees sur les empreintes d'elements lourds mesurees par la spectroscopie atomique. La spectrometrie de masse a multicollection a couplage a plasma induit (MC-ICP-MS) est reconnue comme la methode optimale pour effectuer des mesures de haute precision de nombreux elements du tableau periodique en controlant simultanement les rapports entre leurs isotopes stables. Cette etude presente une nouvelle strategie analytique basee sur des isotopes stables non-traditionnels combines avec des elements traces determines par ICP-MS. Les avantages de combiner les informations de deux systemes isotopiques, l'un tracant le sol (Sr), et l'autre tracant la pollution environnementale ambiante (Pb), ont permis d'obtenir de nouvelles informations exceptionnelles sur la tracabilite et l'authenticite des matrices alimentaires selectionnees : vins de Bordeaux, jambons secs et the. En utilisant des techniques analytiques complementaires telles que les empreintes des elementaires traditionnelles, la specification regionale, ainsi que le tracage du processus de preparation des aliments sont possibles. Traitee par la chimiometrie, cette approche analytique constitue un nouvel outil efficace et prometteur pour detecter des fraudes alimentaires, y compris l’imitation de produits de grande valeur, l’etiquetage errone et la substitution par des produits moins cher.
Fever of unknown origin: evaluation of 110 classical and HIV-associated cases in the last decade

ABSTRACT Background Fever is one of the critical symptoms of collagen vascular diseases, malignancies, and infectious diseases. Patients with a fever of unknown origin (FUO) were evaluated to determine the etiology. Methods In this study, 110 cases with FUO who were admitted to two hospitals with a total of 800 beds, in which 5000 daily outpatient patients were admitted between 2006 and 2016 have been evaluated retrospectively. Anamnesis and the findings were obtained from hospital records. Patients with a temperature higher than 38.3°C and lasting three weeks or longer without diagnosis despite one week of investigation in the hospital were included as FUO cases in this study. Nosocomial and neutropenic cases were excluded from the present study. Results Fifty-seven patients were male (52%), and the mean age was 40.2 ± 17.2. The distribution of the classic and HIV-associated cases was 85 (77.3%) and 18 (16.4%). Tuberculosis (TB) was the most frequent disease in both groups. The etiology was infectious in 68.2%, autoimmune in 14.5%, and neoplastic in 5.4%. There was no case of collagen vascular disease in the HIV-associated FUO group. Conclusion As a result of our study, infectious diseases and TB were still the leading factors that caused FUO. TB has been notably found higher in the HIV-associated group than the classic group. FUO is usually either a rare cause or an unusual clinical presentation of a well-known infectious disease in Turkey. Therefore, it should be noted that various manifestations of extra-pulmonary tuberculosis may be considered a FUO case.
A Comparison of Five Methods for Estimating the Standard Error of Measurement at Specific Score Levels

The Standards for Educational and Psychological Testing (1985) recommended that test publishers pro vide multiple estimates of the standard error of mea surement—one estimate for each of a number of widely spaced score levels. The presumption is that the standard error varies across score levels, and that the interpretation of test scores should take into ac count the estimate applicable to the specific level of the examinee. This study compared five methods of estimating conditional standard errors. All five of the methods yielded a maximum value close to the middle of the score scale, with a sharp decline occurring near the extremes of the scale. These trends probably char acterize the raw score standard error of most standard ized achievement and ability tests. Other types of tests, constructed using alternative principles, might well exhibit different trends, however. Two methods of estimation were recommended: an approach based on polynomial smoothing of point estimates suggested by Thorndike (1951) for specific score levels and a modification proposed by Keats (1957) for the error variance derived under the binomial error model of Lord (1955).
Scarring in External Dacryocystorhinostomy: Fact or Fiction?

Purpose: To determine patients' long-term satisfaction with external dacryocystorhinostomy (DCR) with respect to the visibility of the scar and the resolution of symptoms. Method: A single postal questionnaire with stamped addressed envelope for reply was sent to 204 sequential external primary DCR patients operated on by AAM from January 1999 to April 2002. Results: Of the 79% who replied, 67% rated the scar as invisible with 97% happy with the scar. In 92% the epiphora was either improved or cured and 85% would recommend the operation. Younger patients were significantly more likely to rate the scar as visible but equally likely to rate the scar as good or better. Women were no more likely than men to rate the scar as visible, but if visible, were more likely to consider the scar poor. Conclusions: There was an excellent response rate for a single questionnaire. Patient satisfaction with the DCR scar is very high, with the majority considering the scar invisible. Only 3% remained unhappy with the scar. Overall patient satisfaction with external DCR is very high, for the majority of patients the procedure is effective, and 85% would recommend the operation.
Software and Hardware Techniques for Efficient Polymorphic Calls

Object-oriented code looks different from procedural code. The main difference is the increased frequency of polymorphic calls. A polymorphic call looks like a procedural call, but where a procedural call has only one possible target subroutine, a polymorphic call can result in the execution of one of several different subroutines. The choice is made at run time, and depends on the type of the receiving object (the first argument). Polymorphic calls enable the construction of clean, modular code design. They allow the programmer to invoke operations on an object without knowing its exact type in advance. This flexibility incurs an overhead: in general, polymorphic calls must be resolved at run time. The overhead of this run time polymorphic call resolution can lead a programmer to sacrifice clarity of design for more efficient code, by replacing instances of polymorphic calls by several single-target procedural calls, removing run time polymorphism. This practice typically leads to a more rigid program structure and code duplication, increasing the short term effort required to build a functional prototype, and the long term effort of maintaining and adapting a program to changing needs. We study techniques to minimize the run-time cost of polymorphic calls. In the software domain, we minimize the memory overhead of table based implementations (message dispatch tables), which are most efficient in terms of number of instructions executed. In the hardware domain, we reduce the cycle cost of these instructions through indirect branch prediction. For reasonable transistor budgets, hit rates of more than 95% can be achieved. As a result, only one out of twenty polymorphic calls incurs significant cost at run time. Design of clear, maintainable and reusable code, as enabled by object-oriented technology, can thereby become less restrained by efficiency considerations. Only in very time-critical program segments should the programmer avoid the use of polymorphism. In other words, object-oriented code can become the norm rather than the exception. From our own experience in building software architectures, we consider this a Good Thing.
Internal shocks at the origin of the flat spectral energy distribution of compact jets

An internal shock model is proposed to interpret the radio to infrared (IR) emission of the compact jets observed in the hard spectral state of X-ray binaries. Assuming that the specific bulk Lorentz factor of the jet at its base varies with a flicker noise power spectrum [i.e. P(f) ∝ 1/f], we estimate the energy dissipation profile along the jet and the resulting partially self-absorbed synchrotron emission. For this type of velocity fluctuations, and a conical jet geometry, the shock dissipation at large distance from the black hole balances exactly the adiabatic losses. This leads to a flat radio to IR spectral energy distribution similar to that observed in compact jets.
Avaliação da atenção pré-natal da Estratégia Saúde da Famíliano Município de Santa Helena de Goiás.

Estudo de corte transversal descritivo, que avaliou a atencao pre-natal da Estrategia Saude da Familia no Municipio de Santa Helena de Goias, com utilizacao de indicadores de estrutura, processo e resultados, tendo como referencia os criterios e recomendacoes estabelecidos pelo Programa de Humanizacao no Pre-natal e Nascimento. Os dados foram coletados em entrevistas estruturadas com 85 puerperas internadas no Hospital Municipal de Santa Helena, no periodo de janeiro a abril de 2012, e em registros de prontuarios clinicos e cartoes de gestantes. Para avaliacao da estrutura, utilizou-se de instrumento especifico, com base nos requisitos minimos para o atendimento pre-natal. Para avaliacao do processo, os resultados foram categorizados em quatro niveis de adequacao, obedecendo a uma sequencia somativa, em que o Nivel 1 corresponde ao Indice de Kessner, modificado por Coutinho; no Nivel 2 acrescentaram-se os procedimentos clinicos obstetricos; no Nivel 3 foram somados os exames laboratoriais complementares; e, no Nivel 4, somou-se a realizacao da consulta puerperal. Para avaliacao dos resultados da atencao, foram utilizados como indicadores a proporcao de baixo peso e de prematuridade ao nascer. Os resultados mostraram ser a estrutura das unidades satisfatoria para a implementacao da assistencia pre-natal com qualidade. Os perfis sociodemografico, economico e obstetrico da amostra identificaram um grupo composto por mulheres jovens (media de 23,2 anos), pardas (42,4%), com 5 a 9 anos de estudos (42,4%), com companheiros fixos (82,4%), eles os principais provedores, com renda mensal familiar entre 1 e 3 salarios minimos; a maioria, multigestas (56,5%), com baixo risco gestacional (43,5%), apresentaram medias de inicio do pre-natal com 12,4 semanas de gestacao e7,4 consultas; 71,8% das gestacoes foram encerradas por partos vaginais. Em relacao ao processo assistencial, observou-se 70,6% de adequacao para o Nivel 1, e nenhuma adequacao para os demais niveis propostos. A inadequacao apresentou-se de forma abrupta a partir do Nivel 2, com 88,2%, e 98,5% nos Niveis 3 e 4. Quanto aos indicadores de resultados, encontrou-se 7,0% dos recem-nascidos com baixo peso e 8,2% prematuros, valores considerados aceitaveis pela OMS. A avaliacao global indica a necessidade urgente de qualificacao dos profissionais para otimizacao dos recursos disponiveis, desempenho adequado das acoes preconizadas pelo Ministerio da Saude, assim como sensibilizacao sobre a importância de seus registros, tanto como documentacao da atencao oferecida quanto como indicadores de qualidade.