Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicopathological characteristics of RHOA mutations in a Central European gastric cancer cohort

Genomically stable gastric cancers (GCs) are enriched for the diffuse phenotype and hotspot mutations of RHOA. Here we aimed to validate the occurrence, phenotype and clinicopathological characteristics of RHOA mutant GCs in an independent Central European GC cohort consisting of 415 patients. The RHOA genotype (exon 2 and 3) was correlated with various genotypic, phenotypic and clinicopathological patient characteristics. Sixteen (3.9%) tumours had a RHOA mutation including four hitherto unreported mutations, that is, p.G17Efs*24, p.V24F, p.T37A and p.L69R. RHOA mutation was more prevalent in women (5.4% vs 2.8%), distal GCs (4.5% vs 2.4%), in poorly differentiated GCs (G3/G4; 4.8% vs 1.1%), T1/T2 tumours (6.2% vs 3.1%) and lacked distant metastases. Nine RHOA mutant GCs had a diffuse, four an intestinal, two an unclassified and one a mixed Laurén phenotype. KRAS and RHOA mutations were mutually exclusive. A single case showed both a RHOA and a PIK3CA mutation. No significant difference was found in the overall survival between RHOA mutant and wildtype GCs. Our study confirms the occurrence and clinicopathological characteristics of RHOA hotspot mutations in an independent patient cohort. However, we found no evidence for a prognostic or growth advantageous effect of RHOA mutations in GC.
Day of the week lost time occupational injury trends in the US by gender and industry and their implications for work scheduling

While there is a growing body of research on the impact of work schedules on the risk of occupational injuries, there has been little investigation into the impact that the day of the week might have. The present research was completed to explore day of the week trends, reasons for such trends and the corresponding implications for work scheduling. Data for the number of injuries and illnesses involving days away from work (lost time; LT) in 2004 were provided by the US Bureau of Labor Statistics Office of Safety and Health Statistics. Data from the American Time Use Survey database were used to estimate work hours in 2004. From these two data sources, the rate of LT injuries and illnesses (per 200 000 work hours) by day of the week, industry sector and gender were estimated. The analysis revealed clear differences by day of the week, gender and major industry sector. Sundays had the highest rate overall – nearly 37% higher than the average of the remaining days, Monday to Saturday. Mondays had the next highest rate followed closely by Saturdays. This pattern was not the same for males and females. For males, Mondays had the highest LT rate (27% higher than the average of all other days) with all remaining days having essentially the same rate. For females, Sundays and Saturdays had much higher LT rates – 122% and 60% higher, respectively, than the average weekday rate. There were also differences by industry and differences between genders by industry. The present analysis suggests that several factors may be contributing to the weekend and Monday trends observed. Lower-tenured (and younger) workers on the weekends, lower female management/supervision and second jobs on the weekend seem to be contributors to the high Saturday and Sunday LT rates. Differences in day of the week employment by industry did not account for the trends observed. Fraud and overtime also could not be confirmed as contributing to these trends. Monday trends were more complex to explain, with possible explanations including non-work-related weekend injuries being reported on Mondays, soft-tissue symptoms becoming more noticeable on Mondays, greater Monday morning flexion risk and reduced supervision in the construction industry on Mondays. Interpretation of these trends and the implications for work scheduling are discussed.
Distribution of nitrogen-13 from labeled nitrate and nitrite in germfree and conventional-flora rats

The in vivo distribution of physiological concentrations of NO3- and NO2- labeled with 13N was studied in germfree and conventional-flora Sprague-Dawley rats after gastric intubation (gavage), intravenous (cardiac or tail vein), or intraluminal (intestinal) injection. Some in vitro studies were performed to determine the influence of the bacterial flora on ion distribution. After gavage with 13NO3-, essentially all of the label passed into the upper small intestine, where most was absorbed; however, up to 24% of the 13N could reach the ileum within 1 h. Gavage with 13NO2- resulted in some gastric absorption of the label, but most seemed to exit the stomach via passage into the duodenum. The exit of 13NO2- from the stomach was slower, and less 13N appeared to be absorbed from the small intestine than with 13NO3-. Movement of label through the gastrointestinal tract could be enhanced by inducing diarrhea. Absorbed 13N was either excreted in the urine, reentered the gastrointestinal tract at various points, or was temporarily stored in the eviscerated carcass. The bacterial flora, either by incorporation or chemical alteration, appeared to have some influence on the distribution of 13N from 13NO3- or 13NO2-.
The effect of succinate and amytal on the reduction of acetoacetate in animal tissues.

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COLOR IN SUNGLASS LENSES*

ABSTRACT The extensive literature dealing with color in sunglasses is reviewed. With the exception of therapy in some uncommon illnesses, there is generally no advantage to vision gained by observing through colored, as opposed to neutrally‐tinted, lenses. On the other hand, some types of colored lenses have previously been shown to introduce considerable potential hazards in road traffic where traffic signal lights are used. It is concluded that all sunglasses, tinted contact lenses, and motor vehicle windshields should comply with the coloration limits previously proposed, viz., that the “signal visibility factor” (ratio of red to white light transmission) should be between 0.8 and 1.2, and that the excitation purity should not exceed 20%.
Effect of pharmaceutical care on medication adherence and hospital admission in patients with chronic obstructive pulmonary disease (COPD): a randomized controlled study.

BACKGROUND Poor adherence leads to a high rate of exacerbation and poor health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD). However, few strategies are acceptable and effective in improving medication adherence. We investigated whether pharmaceutical care by clinical pharmacists could reinforce medication adherence to reduce exacerbation and improve HRQoL. METHODS A randomized controlled study was carried out at The First Affiliated Hospital of Guangzhou Medical University from February 2012 to January 2014. Non-adherence patients were randomly assigned to receive pharmaceutical care or to usual care. The pharmaceutical care consisted of individualized education and a series of telephone counseling for 6 months provided by clinical pharmacists. Medication adherence was measured by pill counts plus direct interview at 1- and 6-month pharmaceutical care and one-year follow-up. Severe exacerbations were defined as events that led to hospitalization for acute COPD attack. An interview was conducted to investigate hospital admissions and evaluate severe exacerbations at one-year follow-up. HRQoL was measured by St George's Respiratory Questionnaire at 6 months. RESULTS At 6-month pharmaceutical care and one-year follow-up, the pharmaceutical care group exhibited higher medication adherence than the usual care group (73.4±11.1 vs. 55.7±11.9, P=0.016 and 54.4±12.5 vs. 66.5±8.6, P=0.039, respectively). There are 60 acute exacerbations resulted in a hospital admission in the usual group while 37 ones in the pharmaceutical care group during one-year follow-up (P=0.01). Hospital admissions due to acute exacerbation in the pharmaceutical care group were 56.3% less than the usual care group (P=0.01). There was a significant difference in the symptoms and impact subscales respectively at 6-month pharmaceutical care between two groups (P=0.032, P=0.018). CONCLUSIONS Individualized pharmaceutical care improved medication adherence, reduced hospitalization and elevated HRQoL in patients with COPD.
Pathogenesis of schistosomal ‘pipestem’ fibrosis: a low‐protein diet inhibits the development of ‘pipestem’ fibrosis in mice

Mice maintained on a low protein diet for 30 days and then infected with Schistosoma mansoni for 16 weeks completely failed to develop ‘pipestem fibrosis’ of the liver, whereas 50% of well nourished controls did. Usually mice with relatively mild and prolonged S. mansoni infection develop two different pathological pictures: one consisting of disseminated portal fibrosis caused by periovular granulomas concentrated at the portal spaces (pipestem fibrosis), the other represented by scattered hepatic granulomas. The reason for this dual response is poorly understood. Combined results from parasitological, histopathological, biochemical and morphometric data revealed that peri‐ovular granulomas of undernourished mice were smaller, inflammation was less intense and there was minimal fibrosis in comparison with those of controls, which suggest that a vigorous host response is necessary for the pathogenesis of schistosomal portal fibrosis.
Impact of thyroidectomy without laryngeal nerve injury on vocal quality characteristics: An objective multiparameter approach

The main purpose of this study was to determine the impact of thyroidectomy on the subjective and objective vocal quality using the Dysphonia Severity Index. It was hypothesized that objective measures of vocal function and other vocal characteristics would change (temporarily or permanently) from the presurgical to the postsurgical conditions, even with the entire preservation of the laryngeal nerve, due to the surgical approach and other influencing factors.
Diurnal patterns and regulation of cortisol secretion in pregnancy.

Plasma concentrations of cortisol and corticosteroid-binding globulin are elevated substantially in pregnancy; only the free cortisol fraction is biologically active. Previous suggestions that plasma free cortisol increased above nongravid levels in pregnancy were difficult to reconcile with the absence of manifestations of hypercortisolism. Furthermore, any such elevation should be associated with some alteration in the regulation of cortisol secretion. Therefore, the physiology of cortisol secretion was studied by measuring plasma cortisol at 20-min intervals for 24 h. Free cortisol levels were evaluated by determining the plasma free cortisol index and the rate of urinary cortisol excretion. Circadian cortisol patterns in pregnant and nonpregnant subjects were virtually identical, but total plasma cortisol was significantly higher in pregnancy. Calculated plasma biological half-lives and production rates of cortisol were increased significantly in gravidas (t½: pregnant, 104.6 min; nonpregnant, 69.5 mi.
Attention Distribution and Decision Making in Tactical Air Combat

Tactical decision making in the air combat environment requires the rapid processing of large amounts of data in a complex and unpredictable environment. To investigate decision making in this domain, we conducted a study in which 10 experienced fighter pilots provided tactical decisions and performed a target replacement task on a tactical situation display showing a wide variety of tactical situations based on the de Groot memory paradigm. Results were analyzed to determine features related to pilot attention distribution in processing tactical situation displays and their correspondence to tactical decision making. Evidence is provided for the effect of target quantity, target location, and overall target density distribution on decision making and attention. In addition, substantial variation in decision making was found between participants. Systematic biases in attention were also discovered which have implications for decision making in combat situations. Evidence of chunking in processing the displays was also explored. Results indicate that although pilots appeared to chunk targets in a manner similar to experts studied in other fields, the criterion used for determining chunking in these studies may not be valid.
Smoking and suicidality among psychiatric patients.

OBJECTIVE This study investigated the relationship between smoking and suicidality among psychiatric patients. METHOD All psychiatric patients (N = 1,217) from Kuopio University Hospital in eastern Finland were examined for current smoking, suicidal ideation, previous suicide attempts, and other risk factors by using a cross-sectional, multivariate design. RESULTS The probability of at least one previous suicide attempt was 100% higher in current smokers than in nonsmokers. Smokers also had a 43% higher risk of experiencing mild to severe suicidal ideation than nonsmokers. CONCLUSIONS Current smoking was significantly related to suicidality in multiple logistic models, even after several confounding factors were controlled. The independence of this association seems possible, but the subject requires further research.
Stabilization of lysozyme by the introduction of Gly-Pro sequence.

Three mutant lysozymes where the Asp101-Gly102 sequence of lysozyme was converted to Asp101-Pro102, Gly101-Pro102 and Pro101-Gly102 were prepared to investigate the effect of proline residues on the stabilization of proteins. The free energy changes of lysozymes for the unfolding in aqueous solution at pH 5.5 and 35 degrees C were 10.0, 10.1, 11.0 and 7.7 kcal/mol for wild type, Asp101Pro102, Gly101Pro102 and Pro101Gly102 lysozyme respectively. When the energy level in the unfolded state of wild type lysozyme was fixed at a standard level, the energy levels in the folded state of Asp101Pro102 and Pro101Gly102 lysozymes were found to be higher than that of wild type lysozyme on the basis of delta GD(H2O) and entropy losses of their polypeptide chains in the unfolded state. The presence of some strain in the folded state of these lysozymes was supported by both the calculation of conformational energy for a trans-L-prolyl residue [Schimmel, P.R. and Flory, P.J. (1968) J. Mol. Biol., 34, 105-120] and the analysis of structures of energy-minimized mutant lysozymes. Therefore, it is concluded that the formation of the Gly-Pro sequence is effective in avoiding possible strain in the folded state of a protein caused by the introduction of proline residue(s).
ICU Admission Source as a Predictor of Mortality for Patients With Sepsis

Purpose: Sepsis is the leading noncardiac cause of intensive care unit (ICU) death. Pre-ICU admission site may be associated with mortality of ICU patients with sepsis. This study quantifies mortality differences among patients with sepsis admitted to an ICU from a hospital ward, emergency department (ED), or an operating room (OR). Methods: We conducted a retrospective cohort study of 1762 adults with sepsis using ICU record data obtained from a clinical database of an academic medical center. Survival analysis provided crude and adjusted hazard rate ratio (HRR) estimates comparing hospital mortality among patients from hospital wards, EDs, and ORs, adjusted for age, sex, and severity of illness. Results: Mortality of patients with sepsis differed based on the pre-ICU admission site. Compared to patients admitted from an ED, patients admitted from hospital wards had higher mortality (HRR: 1.35; 95% confidence interval [CI]: 1.09-1.68) and those admitted from an OR had lower mortality (HRR: 0.37; 95% CI: 0.23-0.58). Conclusion: Patients with sepsis admitted to an ICU from a hospital ward experienced greater mortality than patients with sepsis admitted to an ICU from an ED. These findings indicate that there may be systematic differences in the selection of patient care locations, recognition, and management of patients with sepsis that warrant further investigation.
Fog computing based efficient IoT scheme for the Industry 4.0

Industry 4.0 aims to dramatically enhance the productivity of manufacturing technologies through the collection and analysis of real-time data. This combines the ubiquity of the IoT with the processing capabilities of cloud computing to generate insights that help to optimize the decision making process. The increasing demand of data and the explosion in the number of sensing devices, which might be highly constrained in terms of communication, battery and computational power, introduce new challenges that need efficient IoT-Cloud architectures. With this in mind, we extend MQTT, the de facto IoT communication protocol, using a fog computing approach that introduces a low complexity computational layer between the Cloud and IoT nodes. In this approach, the MQTT broker, which is in charge of relaying data from publishers to subscribers, is placed at the fog layer. The purpose of introducing an intermediate layer to this particular scenario is to: i) predict future data measurements through prediction techniques; ii) operate as a gateway to upper layers; and iii) provide the capability to offload computationally expensive data processing jobs from the Cloud to the Fog, minimizing additional latency and operational expenses. With this architecture, the transmissions required from IoT devices may be reduced, since the publishers would only need to update the predicted data in case of mismatching. We validate our approach with an energy consumption analysis and simulations of different Machine Learning algorithms on a real dataset, and compare it with the traditional MQTT scheme.
Spatial Proximity to the U.S.—Mexico Border and Newspaper Coverage of Immigration Issues

This article examines how geographic proximity to the U.S.—Mexico border influences newspaper coverage of immigration issues. The authors investigate two questions: Do media organizations spatially proximate to the border offer more frequent coverage of Latino immigration than media organizations farther removed from the border? Do media organizations spatially proximate to the border offer more frequent coverage of the negative aspects of immigration than media organizations farther removed from the border? We find that news organizations closer to the border generate a higher volume of articles about Latino immigration, articles featuring the negative aspects of immigration, and articles regarding illegal immigration.
Foreign Capital and Economic Growth in the First Era of Globalization

We explore the association between income and international capital flows between 1880 and 1913. Capital inflows are associated with higher incomes per capita in the long-run, but capital flows also brought income volatility via financial crises. Crises also decreased growth rates of income per capita significantly below trend for at least two years leading to important short term output losses. Countries just barely made up for these losses over time, so that there is no conditional long-run income loss or gain for countries that experienced crises. This is in contrast to the recent wave of globalization when capital importing countries that experienced a crisis seemed to grow relatively faster over fixed periods of time. We discuss some possibilities that can explain this finding.
Robust Nonlinear Control of an Intrinsically Compliant Robotic Gait Training Orthosis

Robot-assisted gait therapy is an emerging rehabilitation practice. This paper presents new experimental results with an intrinsically compliant robotic gait training orthosis and a trajectory tracking controller. The intrinsically compliant robotic orthosis has six degrees of freedom. Sagittal plane hip and knee joints were powered by the actuation of pneumatic muscle actuators in opposing pair configuration. The orthosis has passive hip abduction/adduction joint and passive mechanisms to allow vertical and lateral translations of the trunk. A passive foot lifter having a spring mechanism was used to ensure sufficient dorsiflexion during swing phase. A trajectory tracking controller based on a chattering-free robust variable structure control law was implemented in joint space to guide the subject's limbs on physiological gait trajectories. The performance of the robotic orthosis was evaluated during two gait training modes, namely, “trajectory tracking mode with maximum compliance” and “trajectory tracking mode with minimum compliance. ” The experimental evaluations were carried out with ten neurologically intact subjects. The results show that the robotic orthosis is able to perform the gait training task during the two gait training modes. All the subjects tend to deviate from the reference joint angle trajectories with an increase in robotic compliance as the subjects have more freedom to voluntarily drive the robotic orthosis.
Matrix Box-Cox Models for Multivariate Realized Volatility

We propose flexible models for multivariate realized volatility dynamics which involve generalizations of the Box-Cox transform to the matrix case. The matrix Box-Cox model of realized covariances (MBC-RCov) is based on transformations of the covariance matrix eigenvalues, while for the Box-Cox dynamic correlation (BC-DC) specification the variances are transformed individually and modeled jointly with the correlations. We estimate transformation parameters by a new multivariate semiparametric estimator and discuss bias-corrected point and density forecasting by simulation. The methods are applied to stock market data where excellent in-sample and out-of-sample performance is found.
Taking Two Steps to Climb onto the Stage: Capital Taxes as Link between Trade and Growth

This contribution provides evidence for the hypothesis that trade increases growth through its curbing effect on capital taxes. The analyzed mechanism includes two different steps and considers the critical points of both the theoretical and empirical studies in this field. In particular, the estimation problems of omitted variables and parameter heterogeneity are addressed. Using panel data for a sample of 12 OECD countries in the time period 1967-1996, it is shown that the theoretical predictions can be corroborated by empirical results.
Motor Innervation of the Human Cricopharyngeus Muscle

Innervation of the human cricopharyngeus muscle remains historically controversial and unclear, encouraging numerous treatments inconsistently designed to pharmacologically or mechanically alter the contractile state of this muscle. Neuroanatomic controversy results from and is perpetuated by 1) use of nonhuman models, 2) observational misinterpretation of small-diameter, overlapping nerve fibers, and, most importantly, 3) lack of real-time verification of neural projections. We sought to overcome these difficulties by performing microdissections in 27 patients undergoing laryngectomy and using real-time electromyographic verification. We demonstrated 1) dual ipsilateral innervation by the pharyngeal plexus and recurrent laryngeal nerve, 2) segmental projection of the recurrent laryngeal nerve to anterior motor units, 3) pharyngeal plexus projection to posterior motor units, 4) absence of a sympathetic or external superior laryngeal nerve contribution, and 5) absence of contralateral innervation. Suchdual ipsilateral innervation, segmentally projected, has not been previously described in any other form of neuromuscular organization. Neuroanatomic accuracy should improve diagnostic and therapeutic strategies for future management of pharyngeal dysphagia.