Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential biomarkers and therapeutic targets in cervical cancer: Insights from the meta-analysis of transcriptomics data within network biomedicine perspective

The malignant neoplasm of the cervix, cervical cancer, has effects on the reproductive tract. Although infection with oncogenic human papillomavirus is essential for cervical cancer development, it alone is insufficient to explain the development of cervical cancer. Therefore, other risk factors such as host genetic factors should be identified, and their importance in cervical cancer induction should be determined. Although gene expression profiling studies in the last decade have made significant molecular findings about cervical cancer, adequate screening and effective treatment strategies have yet to be achieved. In the current study, meta-analysis was performed on cervical cancer-associated transcriptome data and reporter biomolecules were identified at RNA (mRNA, miRNA), protein (receptor, transcription factor, etc.), and metabolite levels by the integration of gene expression profiles with genome-scale biomolecular networks. This approach revealed already-known biomarkers, tumor suppressors and oncogenes in cervical cancer as well as various receptors (e.g. ephrin receptors EPHA4, EPHA5, and EPHB2; endothelin receptors EDNRA and EDNRB; nuclear receptors NCOA3, NR2C1, and NR2C2), miRNAs (e.g., miR-192-5p, miR-193b-3p, and miR-215-5p), transcription factors (particularly E2F4, ETS1, and CUTL1), other proteins (e.g., KAT2B, PARP1, CDK1, GSK3B, WNK1, and CRYAB), and metabolites (particularly, arachidonic acids) as novel biomarker candidates and potential therapeutic targets. The differential expression profiles of all reporter biomolecules were cross-validated in independent RNA-Seq and miRNA-Seq datasets, and the prognostic power of several reporter biomolecules, including KAT2B, PCNA, CD86, miR-192-5p and miR-215-5p was also demonstrated. In this study, we reported valuable data for further experimental and clinical efforts, because the proposed biomolecules have significant potential as systems biomarkers for screening or therapeutic purposes in cervical carcinoma.
The emerging health impact of voluntary medical male circumcision in Zimbabwe: An evaluation using three epidemiological models

Background Zimbabwe adopted voluntary medical male circumcision (VMMC) as a priority HIV prevention strategy in 2007 and began implementation in 2009. We evaluated the costs and impact of this VMMC program to date and in future. Methods Three mathematical models describing Zimbabwe’s HIV epidemic and program evolution were calibrated to household survey data on prevalence and risk behaviors, with circumcision coverage calibrated to program-reported VMMCs. We compared trends in new infections and costs to a counterfactual without VMMC. Input assumptions were agreed in workshops with national stakeholders in 2015 and 2017. Results The VMMC program averted 2,600–12,200 infections (among men and women combined) by the end of 2016. This impact will grow as circumcised men are protected lifelong, and onward dynamic transmission effects, which protect women via reduced incidence and prevalence in their male partners, increase over time. If other prevention interventions remain at 2016 coverages, the VMMCs already performed will avert 24,400–69,800 infections (2.3–5% of all new infections) through 2030. If coverage targets are achieved by 2021 and maintained, the program will avert 108,000–171,000 infections (10–13% of all new infections) by 2030, costing $2,100–3,250 per infection averted relative to no VMMC. Annual savings from averted treatment needs will outweigh VMMC maintenance costs once coverage targets are reached. If Zimbabwe also achieves ambitious UNAIDS targets for scaling up treatment and prevention efforts, VMMC will reduce the HIV incidence remaining at 2030 by one-third, critically contributing to the UNAIDS goal of 90% incidence reduction. Conclusions VMMC can substantially impact Zimbabwe’s HIV epidemic in the coming years; this investment will save costs in the longer term.
The Phylogeny of the Extant Hexapod Orders

Morphological and molecular data are marshalled to address the question of hexapod ordinal relationships. The combination of 275 morphological variables, 1000 bases of the small subunit nuclear rDNA (18S), and 350 bases of the large subunit nuclear rDNA (28S) are subjected to a variety of analysis parameters (indel and transversion costs). Representatives of each hexapod order are included with most orders represented multiply. Those parameters that minimize character incongruence (ILD of Mickevich and Farris, 1981, Syst. Zool. 30, 351–370), among the morphological and molecular data sets are chosen to generate the best supported cladogram. A well‐resolved and robust cladogram of ordinal relationships is produced with the topology (Crustacea ((Chilopoda Diplopoda) ((Collembola Protura) ((Japygina Campodeina) (Archaeognatha (Zygentoma (Ephemerida (Odonata ((((Mantodea Blattaria) Isoptera) Zoraptera) ((Plecoptera Embiidina) (((Orthoptera Phasmida) (Grylloblattaria Dermaptera)) ((((Psocoptera Phthiraptera) Thysanoptera) Hemiptera) ((Neuropteroidea Coleoptera) (((((Strepsiptera Diptera) Mecoptera) Siphonaptera) (Trichoptera Lepidoptera)) Hymenoptera)))))))))))))).
The radio core and jet in the broad absorption-line quasar PG 1700+518

The blueshifted broad absorption lines (BAL) or troughs are observed in active galactic nuclei (AGNs) when our line of sight is intercepted by a high-speed outflow (wind), likely originating in the accretion disc. The outflow or wind can shed light on the internal structure obscured by the AGN torus. Recently, it has been shown that this outflow is rotating in the BAL quasar PG 1700+518, further supporting the accretion disc origin of the wind. With the purpose of giving independent constraints on the wind geometry, we performed high-resolution European very long baseline interferometry (VLBI) Network (EVN) observations at 1.6 GHz in 2010. Combining the results with the Very Large Array (VLA) archival data at 8.4 GHz, we present its jet structure on scales of parsec (pc) to kiloparsec (kpc) for the first time. The source shows two distinct jet features in east-west direction with a separation of around 4 kpc. The eastern feature, which has so far been assumed to hide the core, is a kpc-scale hotspot, which is completely resolved out in the EVN image. In the western jet feature, we find a compact jet component, which pinpoints the position of the central black hole in the galaxy. Jet components on both sides of the core are additionally detected in the north-west-south-east direction, and they show a symmetric morphology on scale of < 1 kpc. This two-sided jet feature is not common in the known BAL quasars and indicates that the jet axis is far away from the line of sight. Furthermore, it is nearly parallel to the scattering plane revealed earlier by optical polarimetry. By analogy to polar-scattered Seyfert 1 galaxies, we conclude that the jet likely has a viewing angle around 45 degrees. The analogy is further supported by the recent report of significant cold absorption in the soft X-rays, a nearly unique feature to polar-scattered Seyfert galaxies. Finally, our observations have confirmed the earlier finding that the majority of radio emission in this galaxy arises from AGN activity rather than star formation.
THERMAL MODEL CALIBRATION FOR MINOR PLANETS OBSERVED WITH WIDE-FIELD INFRARED SURVEY EXPLORER/NEOWISE

With the Wide-field Infrared Survey Explorer (WISE), we have observed over 157,000 minor planets. Included in these are a number of near-Earth objects, main-belt asteroids, and irregular satellites which have well measured physical properties (via radar studies and in situ imaging) such as diameters. We have used these objects to validate models of thermal emission and reflected sunlight using the WISE measurements, as well as the color corrections derived in Wright et al. for the four WISE bandpasses as a function of effective temperature. We have used 50 objects with diameters measured by radar or in situ imaging to characterize the systematic errors implicit in using the WISE data with a faceted spherical near-Earth asteroid thermal model (NEATM) to compute diameters and albedos. By using the previously measured diameters and H magnitudes with a spherical NEATM model, we compute the predicted fluxes (after applying the color corrections given in Wright et al.) in each of the four WISE bands and compare them to the measured magnitudes. We find minimum systematic flux errors of 5%–10%, and hence minimum relative diameter and albedo errors of ∼10% and ∼20%, respectively. Additionally, visible albedos for the objects are computed and compared to the albedos at 3.4 μm and 4.6 μm, which contain a combination of reflected sunlight and thermal emission for most minor planets observed by WISE. Finally, we derive a linear relationship between subsolar temperature and effective temperature, which allows the color corrections given in Wright et al. to be used for minor planets by computing only subsolar temperature instead of a faceted thermophysical model. The thermal models derived in this paper are not intended to supplant previous measurements made using radar or spacecraft imaging; rather, we have used them to characterize the errors that should be expected when computing diameters and albedos of minor planets observed by WISE using a spherical NEATM model.
SEARCHING FOR DARK MATTER ANNIHILATION IN THE SMITH HIGH-VELOCITY CLOUD

Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use γ-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant γ-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section (∼ 3 × 10−26 cm3 s−1) for dark matter masses ≲ 30 GeV annihilating via the or τ+τ− channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.
Nas ondas do surfe: estilos de vida, territorialização e experimentação juvenil no espaço urbano

ALBUQUERQUE, Cynthia Studart. Nas ondas do surfe: estilos de vida, territorializacao e experimentacao juvenil no espaco urbano. 2006. 211f. Dissertacao (Mestrado em Sociologia)- Universidade Federal do Ceara, Departamento de Ciencias Sociais, Programa de Pos-Graduacao em Sociologia, Fortaleza-CE, 2006.
Occurrence of P element in natural populations of Drosophila melanogaster in Ukraine

Using PCR and sequencing we have demonstrated the presence of P elements in genomes of Drosophila melanogaster from natural populations of Ukraine. The degree of gonadal reduction revealed indirectly indicates low or, in some cases, zero activity of the mobile element in the inspected natural populations of Drosophila. All studied populations have been found to represent the M’ cytotype. In this study, we have shown for the first time that P element, absent two decades ago, has invaded Ukrainian populations of Drosophila melanogaster. This invasion is part of the worldwide expansion of P element in Drosophila melanogaster. In Ukraine, an initial stage of the invasion has been suggested to occur, and further evolution of the M’ cytotype into P cytotype is expected.
Theoretical and Experimental Foundations of the "Cancer Stem Cell" Model

Many human tissues are in a state of constant flux, in which large numbers of mature differentiated cells are continuously eliminated and replaced. Despite the shortlived nature of many of their cells, tissues maintain their size and structure over time through a tightly regulated process of proliferation and differentiation. In each tissue, this process is orchestrated by a remarkable population of long-lived cells, called “stem cells” (Weissman, 2000). Historically, the word “stem cell” originated to identify an ancestor/progenitor cell that stands at the “stem” of a genealogic tree, used to depict either evolutionary (i.e., phylogenetic) or developmental (i.e., ontogenetic) processes (Ramalho-Santos and Willenbring, 2007). Its meaning remains essentially intact today, where it is mainly used in developmental biology, to identify a cell capable to generate and sustain over time a specific set of diversified cell populations whose aggregate interaction leads to the formation of either an entire living organism (e.g., embryonic stem cells with pluripotent capacity) or a specific subset of its organs and tissues (e.g., adult stem cells with oligopotent or multipotent capacity) (Weissman, 2000). Traditionally, stem cells are defined by three main properties:
Cesarean Section: Incidence, Causes, Associated Factors and Outcomes: A National Prospective Study from Jordan

Objectives: To determine the rate of cesarean section (CS) in Jordan and its causes, associated factors, and neonatal outcomes. Methods: The study is part of a comprehensive national study of perinatal mortality which was conducted between 2011 and 2012 in Jordan. The study was concurrent prospective in design. A sample of 18 hospitals with maternity departments was selected. All women = 20 weeks of gestation admitted for delivery in any of the 18 selected hospitals were enrolled in the study. Data were collected by interviews and abstraction of data from medical records. Results: The overall rate of CS was 29.1% (13.2% as emergency CS and 15.9% as planned CS). Health sector, income of >350, <12 years of education, increased gestational age at delivery, primiparity, previous CS, male gender, overweight, obesity, pre-gestational and gestational diabetes, non-cephalic presentation, multiple pregnancy, preeclampsia, anemia, smoking, history of neonatal death/stillbirth, and previous hospitalization during current pregnancy were all associated with increased odds of CS in the multivariate analysis. The most frequent reason for planned CS was scarred uterus (59.4%) and for emergency CS was prolonged fetal distress (30.0%). The neonatal death rate was significantly higher (p=0.000) for planned CS (2.1%) and emergency CS (2.5%) as compared to vaginal delivery (0.9%). Conclusion: The rate of CS in Jordan is high (29.1%). CS is associated with increased risk of neonatal death. As most CSs are currently based on physicianâs judgment, it may be extremely useful to develop and implement national guidelines for performing CS. Obstetriciansâ adherence to these guidelines should be strictly monitored.
Test Report on Cold-Formed Steel Shear Walls

SUMMARY The objective of report is to detail recent cyclic tests on cold-formed steel (CFS) framed shear walls sheathed with Oriented Strand Board (OSB). The tests details are motivated from shear walls designed for a two-story ledger-framed building that will undergo full-scale shake table testing as exterior. Practical building details studied in the shear wall tests include the impact of (a) ledger track, which is attached to the top of the interior face of the wall, (b) gypsum, which is attached to the interior face of the wall below the ledger track, (c) locations of panel seams, both horizontal and vertical in the OSB, and (d) the impact of differing stud thickness and grade for the field studs. The information will be used to assess current design procedures utilizing AISI-S213-07 and to develop nonlinear (hysteretic) models of the shear walls in the CFS-NEES model building so that full building system performance can be assessed.
Orange dye—polyaniline composite based impedance humidity sensors

This study presents the fabrication and investigation of humidity sensors based on orange dye (OD) and polyaniline (PANI) composite films. A blend of 3 wt. % OD with 1 wt. % PANI was prepared in 1 ml water. The composite films were deposited on glass substrates between pre-deposited silver electrodes. The gap between the electrodes was 45 μm. The sensing mechanism was based on the impedance and capacitance variations due to the absorption/desorption of water vapor. It was observed that with the increase in relative humidity (RH) from 30% to 90%, the impedance decreases by 5.2×104 and 8.8×103 times for the frequencies of 120 Hz and 1 kHz, respectively. The impedance—humidity relationship showed a more uniform change compared to the capacitance—humidity relationship in the RH range of 30% to 90%. The consequence of annealing, measuring frequency, response and recovery time, and absorption—desorption behavior of the humidity sensor were also discussed in detail. The annealing resulted in an increase in sensitivity of up to 2.5 times, while the measured response time and recovery time were 34 s and 450 s, respectively. The impedance—humidity relationship was simulated.
Robust Sparse Recovery in Impulsive Noise via $\ell _p$ -$\ell _1$ Optimization

This paper addresses the issue of robust sparse recovery in compressive sensing (CS) in the presence of impulsive measurement noise. Recently, robust data-fitting models, such as ℓ1-norm, Lorentzian-norm, and Huber penalty function, have been employed to replace the popular ℓ2-norm loss model to gain more robust performance. In this paper, we propose a robust formulation for sparse recovery using the generalized ℓp-norm with 0 ≤ p <; 2 as the metric for the residual error. To solve this formulation efficiently, we develop an alternating direction method (ADM) via incorporating the proximity operator of ℓp-norm functions into the framework of augmented Lagrangian methods. Furthermore, to derive a convergent method for the nonconvex case of p <; 1, a smoothing strategy has been employed. The convergence conditions of the proposed algorithm have been analyzed for both the convex and nonconvex cases. The new algorithm has been compared with some state-of-the-art robust algorithms via numerical simulations to show its improved performance in highly impulsive noise.
Housing Risk and Return: Evidence from a Housing Asset-Pricing Model

Case, Cotter, and Gabriel investigate the risk–return relationship in the determination of housing asset pricing. In so doing, they evaluate the behavioral hypotheses advanced by Case and Shiller in studies of boom and post-boom housing markets. The authors specify a multifactor housing assetpricing model and evaluate whether the market factor and other measures of risk, including idiosyncratic risk, momentum, and MSA size effects, have explanatory power for metropolitan- specific housing returns. Further, they test the robustness of the asset pricing results to inclusion of controls for socioeconomic variables commonly represented in the house price literature, including changes in employment, affordability, and foreclosure incidence, and find a sizable and statistically significant influence of the market factor on MSA house price returns. Moreover, they show that market betas have varied substantially over time. Results are largely robust to the inclusion of other explanatory variables, including standard measures of risk and other housing market fundamentals. Additional tests of model validity using the Fama–MacBeth framework offer further strong support of a positive risk-and-return relationship in housing. Case, Cotter, and Gabriel’s findings are supportive of the application of a housing investment risk–return framework in explanation of the variation in the metro-area cross section and time series of U.S. house price returns. Further, results strongly corroborate the Case–Shiller survey research, which indicates the importance of speculative forces in the determination of U.S. housing returns.
Characterization of amylase and protease activities in the digestive system of Concholepas concholepas (Gastropoda, muricidae)

Concholepas concholepas (loco) is a carnivorous gastropod that inhabits the coast of Chile and Peru. Its fisheries showed a great importance in the past decades, however, now mainly relies on artisanal management of wild stocks. Feeding is one of the important factors that have restrained the establishment of large scale field rearing of loco. C. concholepas food preferences consist of mytilids and cirripeds, however its digestive physiology has not been studied and its digestive enzymes have not been yet characterized. The purification of amylase and protease from the digestive gland and the gland of Leiblein of C. concholepas were performed by ionic exchange chromatography (DEAE-cellulose), and substrate-PAGE indicated the presence of the amylase and protease in the fractions collected from the column. Amylase enzymatic assays showed its maximum activity at pH 7.0 and 50°C in the digestive gland. Protease on the other hand showed a great acidic activity, specifically at pH 3.0 in both organs, also at 50°C. Inhibition of the amylolytic activity was observed in the presence of EDTA, and metal ions like MnCl2, MgCl2, ZnSO4, while it was enhanced in the presence of CaCl2, NaCl, KCl. Protease inhibition assays were also performed evidencing mainly the presence of aspartic proteases and a low but not inexistent presence of serine proteases. Our results provide evidence of important proteolytic but also amylolytic activities present in the digestive system of loco, providing evidence that this mollusc has wider digestive capabilities than initially though, which could potentially lead to the development of alternative food diets.
The effect of silver nanoparticles and glutamine on molecular responses , and the morphology of pectoral muscle the effect of silver nanoparticles and glutamine on molecular responses , and the morphology of pectoral muscle

Background: It has been demonstrated that concentrations of certain amino acids in the egg, in late-term embryos, are not sufficient to fully support embryonic development. One of the methods to assure an adequate nutrient content in the egg is in ovo administration of nutrients, which increases hatching weight and the size of the breast muscle. The small size of silver nanoparticles allows for penetration inside tissues and even enables them to cross cell membranes. Indeed it has been shown that nanoparticles of silver applied in ovo can up-regulate the expression of fibroblast growth factor and vascular endothelial growth factor. We have therefore tested if silver nanoparticles can affect muscle development of chicken embryos and, furthermore, if they can be used in in ovo nutrition as carriers of nutrients e.g. glutamine into muscle cells. Methods: 160 broiler eggs were randomly divided into the control group (Control) without injection and injected groups with hydrocolloids of nanoparticles of silver (Nano-Ag), glutamine (Glu) and the complex of nanoparticles of silver and glutamine (Nano-Ag/Glu). The embryos were evaluated on day 20 of incubation. Samples of the breast muscles were collected for gene expression analysis or fixed for electron microscopy preparation. Results: Results indicate a significant role of silver nanoparticles and the complex Nano-Ag/Glu in muscle development. Conclusion: Nanoparticles of Ag, glutamine and the complexes of Ag and glutamine were without negative effects on embryo development. Nanoparticles of Ag and the complex of Ag with glutamine increased the number of nuclei per cell number and also fiber area. Furthermore, the complex of Ag with glutamine increased muscle mass.