Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term hospitalization for tuberculosis control. Experience with a medical-psychosocial inpatient unit.

CONTEXT Patients with tuberculosis (TB) who are nonadherent to therapy or have complicated medical or social problems pose a threat to public health. In some cases, hospitalization may be a necessary component of a comprehensive TB control program. OBJECTIVE To describe experience with a new inpatient program for TB control. DESIGN Retrospective review. SETTING Eighteen-bed, secure, TB treatment unit in a state public health hospital providing a spectrum of acute and chronic care services. PATIENTS Patients with known or suspected TB who were unable to be treated as outpatients and were hospitalized from 1990 through 1995. INTERVENTIONS Voluntary or involuntary hospitalization, with medical, psychosocial, and legal services. MAIN OUTCOME MEASURES Admissions, treatment completion, and disposition. RESULTS A total of 166 patients with a confirmed diagnosis of TB accounted for 214 hospitalizations for TB. The mean age was 42 years, 132 (79.5%) were men, 84 (50.6%) were nonwhite, and 45 (27.1%) were foreign born. At the time of admission, 58 patients (34.5%) were homeless, 116 (69.9%) had a history of abuse of alcohol or other drugs, and 46 (31.7%) were positive for human immunodeficiency virus. The mean length of stay was 119.7 days (median, 70 days; range, 7-656 days), and was higher among homeless patients than nonhomeless patients (168.8 vs 93.4 days). Of 48 patients (28.9%) who were admitted involuntarily, 21 required long-term confinement under court order. Admission indications (not mutually exclusive) changed over 5 years: nonadherence decreased (95% to 34%), medical complexity increased (14% to 77%), short-term isolation increased (19% to 39%), and involuntary admission decreased (54% to 13%). Of 157 patients with positive cultures for Mycobacterium tuberculosis, 36 (23.1%) were resistant to at least 1 drug, including 16 who were multidrug resistant. A total of 123 patients (74.7%) were discharged to an outpatient setting to complete therapy, 40 (24.1%) required inpatient care to complete therapy, and 3 died (1 from TB) before discharge. CONCLUSIONS A high proportion of patients with TB who failed outpatient therapy completed treatment in a combined medical and psychosocial inpatient unit. During the 5-year study period, involuntary admissions decreased and most patients completed therapy as outpatients. In Massachusetts, this program plays an important role in protecting public health and in providing specialized medical management for patients to complete therapy in a safe and supportive environment.
Success and Complication Rates with Prehospital Placement of an Esophageal-Tracheal Combitube as a Rescue Airway

Abstract Introduction: Previous studies have proven the success of the EsophagealTracheal Combitube (ETC) as a primary airway, but not as a rescue airway. Objective: The object of this study was to observe success and complication rates of paramedic placement of an ETC as a rescue airway, and to compare success rates with endotracheal tube (ETT) intubation. The primary outcome indicator was placement with successful ventilation. Complication rates, esophageal placement, and return of spontaneous circulation (ROSC) were secondary measures. Methods: A retrospective review of the records of patients who had ETC attempts by Emergency Medical Services (EMS) was conducted for a period of three years. Complications were defined a priori. The ETC is used primarily as rescue airway for a failed attempt at an endotracheal tube (ETT) intubation. A control group for ETT placements was drawn from the EMS quality assurance (QA) database for the same period. Results: Esophageal-Tracheal Combitube insertion was attempted on 162 patients, of which, 113 (70%) were successful, 46 (28%) failed, and the outcome of three (2%) was not recorded. Inability to place the ETC occurred in 29 (18%) patients, and accounted for 48% (22/46) of failures. The use of the ETC caused dental trauma in one patient, and one placement of the ETC was related to the onset of subcutaneous emphysema. Blood in the ETC from active upper gatrointestinal bleeding occurred in nine patients (6%), and four tubes (3%) became dislodged en route to the hospital. The a priori complication rate was 44/162 (27%). Inability to determine placement of the ETC due to emesis from both ports occurred in 21 cases. Combining these problems with the a priori complications, the overall rate was 40% (65/162). EsophagealTracheal Combitube location was noted in a subset of 90 charts, of which, 76 (84%) were esophageal, and 14 (16%) were tracheal. Thirteen of 126 (10%) patients in cardiac arrest had return of spontaneous circulation (ROSC) in the field after placement of the ETC. An ETT was attempted in 128 control patients, of which, 107 (84%) were successful, 21 (16%) failed (odds ratio (OR) for ETT vs. ETC = 2.1; 95% CI = 1.12–3.86). Conclusion: Despite a low ROSC rate, the complication and success rates of ETC are acceptable for a rescue airway device. Tracheal placement of the Combitube is uncommon, but requires fail-safe discrimination. Similar to previous reports, the success ratio for ETT was greater than for the ETC.
Sub-100 nm /spl Gamma/-gate MOSFETs with self-aligned drain extension formed by solid phase diffusion

High performance 60 nm /spl Gamma/-gate n-MOSFETs have been fabricated. The very fine poly-Si gates were made using deposition and etchback of poly-Si to form a sidewall along the conductive poly-Si/PSG dummy stack. Due to the relatively wide dummy stack, the low gate resistance r/sub g/ is independent of the actual gate length; this is especially essential for rf circuits as high gate resistance could severely degrade high frequency performance. The diffusion source, PSG layer underneath the poly-Si, allowed the formation of an ultra-shallow self-aligned drain extension by solid phase diffusion. Together with a steep retrograde channel using indium, good subthreshold characteristics as well as high current drive were obtained.
Non-invasive determination of body composition in pigs using a Norland XR-26 bone densitometer

measurement of body composition provides advantages in growth studies compared to conventional techniques. The same individual can be measured several times, the measurement is faster, and the number of pigs required as well as the random effect of animal are reduced. The aim of the present study was to determine the composition of the half carcass and of the ham/shank region by a whole body dual-energy X-ray absorptiometry (DXA) scan of the live pig using a Norland XR-26. Accuracy and precision of DXA measurement were evaluated by regression analysis between DXA-derived values and chemical analysis as well as dissection. Pigs of different gender were used covering a wide range of body weights and body composition. Single regression analysis for lean and fat mass revealed a close relationship between half carcass DXA and chemical analysis (R² = 0.97 and R² = 0.91, respectively) as well as dissection (R² = 0.99 and R² = 0.98, respectively). The prediction accuracy (R²) was lower for the tissue percentages than for the respective tissue masses. The relationship between live pig DXA and reference methods was close for dissected lean meat (R² = 0.90) and adipose tissue mass (R² = 0.93). For chemical lean and fat mass, R² were slightly lower. Multiple regression analysis using one to four independent variables improved accuracy of prediction. The composition of ham and shank could be predicted more accurately than the half carcass composition.
Isotope composition of Zelkova serrata leaves as an indicator of atmospheric pollution in Japan

In spite of increasing concern regarding the effects of greenhouse gases, atmospheric CO2 concentration continues to increase, with current levels now as high as 370 ppm. This elevated CO2 concentration influences not only atmospheric characteristics, but also ground vegetation: leaf structure, chemical composition and carbon-isotope composition are all affected. It was with this in mind that we investigated the viability of coupling an isotopic and a botanical approach to determine leaf interaction in relation to atmospheric pollution levels. Results show that, among the botanical indexes considered, the most reliable proxy of atmospheric CO2 levels would appear to be leaf mass per area (LMA), which increases with pollution. Our study also shows that LMA determination coupled with carbon-isotope compositions is a sensitive tracer of the local pollution-level variations.
Anti‐tRNP(ser)sec/SLA/LP autoantibodies. Comparative study using in‐house ELISA with a recombinant 48.8 kDa protein, immunoblot, and analysis of immunoprecipitated RNAs

Background: Antibodies against tRNP(ser)sec (ribonucleoproteins, RNP) have been described in our laboratory as markers of poor outcome in type 1 autoimmune hepatitis (AIH). The antigenic protein has been sequenced and cloned as a 48.8 kDa protein and identified with soluble liver antigen (SLA) and liver–pancreas (LP) antigen. The aim of this paper was to determine the best assay by which to detect these antibodies in type 1 AIH.
The objectives, design and implementation of the INTERGROWTH‐21st Project

Please cite this paper as: Villar J, Altman D, Purwar M, Noble J, Knight H, Ruyan P, Cheikh Ismail L, Barros F, Lambert A, Papageorghiou A, Carvalho M, Jaffer Y, Bertino E, Gravett M, Bhutta Z, Kennedy S, for the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH‐21st). The objectives, design and implementation of the INTERGROWTH‐21st Project. BJOG 2013; 120 (Suppl. 2): 9–26.
Agglomeration externalities and technical efficiency: An empirical application to the pond aquaculture of Pangas and Tilapia in Bangladesh

Abstract This article analyzes the effects of agglomeration externalities on productivity and efficiency by applying a stochastic production frontier model with a technical inefficiency model to the aquaculture industry. Agglomeration externalities refer to the costs and benefits to firms from clustering. Agglomeration studies within aquaculture have focused on the intensive salmon industry, whereas this study focuses on low-technology, extensive pond aquaculture, representing most farmers in the developing world and using Bangladesh as an empirical case. The results show that there is a positive externality effect of regional industry size on the production possibility frontier and a negative effect on technical efficiency. Farm density enhances efficiency and the farm proximity to output markets decreases efficiency. Thus, policies aimed at increasing aquaculture pond production in developing countries should consider farm locations and their access to input and output markets, all of which affect farm productivity and efficiency.
The relationship between excessive daytime sleepiness and metabolic syndrome in severe obstructive sleep apnea syndrome

Excessive daytime sleepiness (EDS), which is commonly considered a cardinal sign of obstructive sleep apnea (OSA), may lead to an increased rate of metabolic syndrome (MetS), and be an independent risk factor for cardiovascular morbidity and mortality. The aim of this cross‐sectional study was to examine the role of EDS in MetS and its components by researching severe OSA patients.
Housing market filtering in the Oslo region: pro-market housing policies in a Nordic welfare-state context

Abstract Vacancy chain theory suggests that mobility opportunities spread within and between specific states, typically flowing from attractive to less attractive units, with households moving in the opposite direction. We explore whether such welfare gains apply in a context, the Oslo region, which combines egalitarian welfare programmes and pro-market housing policies. We use merged census and register data from 2011, and include all events that initiate vacancies. Our results show that rental submarkets function poorly. There are many vacancies, but most of them are immediately absorbed by recruits, that is, households who leave no vacancy behind. Opportunities for disadvantaged groups are further reduced by rapid absorption of owner-occupied flats, often because privileged nest-leavers eschew the rental markets. Two related outcomes are segmentation between submarkets and segregation between Oslo Outer East and the remaining city. All of these adverse consequences reflect the costs of current policies, and call for initiatives that increase and improve opportunities in the rental sector.
IL-1 Receptor Antagonist Reduced Chemical-Induced Keratinocyte Apoptosis through Antagonism to IL-1α/IL-1β

Extracellular interleukin 1 alpha (IL-1α) released from keratinocytes is one of the endpoints for in vitro assessments of skin irritancy. Although cells dying via primary skin irritation undergo apoptosis as well as necrosis, IL-1α is not released in apoptotic cells. On the other hand, active secretion has been identified in interleukin-1 receptor antagonist (IL-1ra), which was discovered to be a common, upregulated, differentially-expressed gene in a microarray analysis performed with keratinocytes treated using cytotoxic doses of chemicals. This study examined whether and how IL-1ra, particularly extracellularly released IL-1ra, was involved in chemically-induced keratinocyte cytotoxicity and skin irritation. Primary cultured normal adult skin keratinocytes were treated with cytotoxic doses of chemicals (hydroquinone, retinoic acid, sodium lauryl sulfate, or urshiol) with or without recombinant IL-1ra treatment. Mouse skin was administered irritant concentrations of hydroquinone or retinoic acid. IL-1ra (mRNA and/or intracellular/extracellularly released protein) levels increased in the chemically treated cultured keratinocytes with IL-1α and IL-1β mRNAs and in the chemically exposed epidermis of the mouse skin. Recombinant IL-1ra treatment significantly reduced the chemically-induced apoptotic death and intracellular/extracellularly released IL-1α and IL-1β in keratinocytes. Collectively, extracellular IL-1ra released from keratinocytes could be a compensatory mechanism to reduce the chemically-induced keratinocyte apoptosis by antagonism to IL-1α and IL-1β, suggesting potential applications to predict skin irritation.
Intermittent preventive treatment of malaria in pregnant women and infants: making best use of the available evidence

Introduction: Malaria continues to represent a huge global health burden on the most vulnerable populations. The Intermittent Preventive Treatment (IPT) strategy has been shown to be an efficacious intervention in preventing most of the deleterious effects of malaria in pregnant women and infants. Yet, the effectiveness of the IPT strategy may be impaired by the increasing resistance to sulfadoxine-pyrimethamine (SP), and the scarcity of alternative antimalarial drugs. Areas covered: This review examines all the available information on IPT, in an aim to provide the scientific community with a framework to understand the benefits and limitations of this malaria control strategy. It includes the understanding of the historical background of the IPT strategy, the drug's mechanisms of actions, updated information on current available evidence, the implications of drug resistance and choice of alternative drugs, and a comprehensive discussion on the perspectives of IPT for malaria control in pregnant women and infants. Expert opinion: IPT in pregnancy and infants is a cost-effective strategy that can contribute significantly to the control of malaria in endemic areas. Monitoring its effectiveness will allow tracking of progress, evaluation of the adequacy of currently used drugs and will highlight the eventual need for new therapies or alternative interventions.
Application of Aaker’s Brand Personality Scale on Human Brands in Surf Sports

Abstract Purpose: This research explores the application of Aaker’s brand personality scale on human brands in surf sports. It investigates the potential for detecting differences in the brand personality profile used on human brands. Aaker (1997) developed a brand personality framework consisting out of five dimensions of brand personality and fifteen brand personality attributes. This framework has been used in several studies; however, it has been criticized by researchers for its lack of applicability as a general scale. This paper addresses this issue by testing all forty-two original brand personality attributes, used by Aaker, on professional surfers as human brands. A second objective was to establish an ultra-short scale for practical reasons since brand personality is often only one of several measures in a questionnaire. Methodology: In order to determine what attributes were the most appropriate when describing a professional surfer, a web survey with a 7-point Likert scale was conducted, which resulted in a convenience sample of n=219 respondents. In this study, the author conducted principle factor analysis and compared the results of an oblique rotation with Aaker’s results in order to investigate whether Aaker’s brand personality scale provides similar results on human brands as it does on product brands. Findings: This paper concludes that partially different facets than Aaker’s (1997) brand personality framework apply to human brands in the surf context. The more appropriate facets for human brands in the surf context include: real, wholesome, good-looking, secure, Western, and up-to-date. Research limitations/Implications: Further research on specific athletes in different contexts is needed. It could incorporate other brand personality scales e.g. Geuens et al. (2009), Braunstein and Ross (2010) and Tsiotsou (2012) scales. Practical Implications: The findings of this study are useful for sports marketers to better understand athletes as human brands as well as their facets, in order to develop target positioning with specific marketing strategies.
A Prediction Rule to Stratify Mortality Risk of Patients with Pulmonary Tuberculosis

Tuberculosis imposes high human and economic tolls, including in Europe. This study was conducted to develop a severity assessment tool for stratifying mortality risk in pulmonary tuberculosis (PTB) patients. A derivation cohort of 681 PTB cases was retrospectively reviewed to generate a model based on multiple logistic regression analysis of prognostic variables with 6-month mortality as the outcome measure. A clinical scoring system was developed and tested against a validation cohort of 103 patients. Five risk features were selected for the prediction model: hypoxemic respiratory failure (OR 4.7, 95% CI 2.8–7.9), age ≥50 years (OR 2.9, 95% CI 1.7–4.8), bilateral lung involvement (OR 2.5, 95% CI 1.4–4.4), ≥1 significant comorbidity—HIV infection, diabetes mellitus, liver failure or cirrhosis, congestive heart failure and chronic respiratory disease–(OR 2.3, 95% CI 1.3–3.8), and hemoglobin <12 g/dL (OR 1.8, 95% CI 1.1–3.1). A tuberculosis risk assessment tool (TReAT) was developed, stratifying patients with low (score ≤2), moderate (score 3–5) and high (score ≥6) mortality risk. The mortality associated with each group was 2.9%, 22.9% and 53.9%, respectively. The model performed equally well in the validation cohort. We provide a new, easy-to-use clinical scoring system to identify PTB patients with high-mortality risk in settings with good healthcare access, helping clinicians to decide which patients are in need of closer medical care during treatment.
Predictors of Early Neurological Deterioration after Ischaemic Stroke: A Case-Control Study

Background: Early neurological deterioration after ischaemic stroke (stroke in progression) is reported to be common and associated with poor outcome or death. The causes of progressing stroke are, however, uncertain. Objective: To determine whether prior drug treatment (with anticoagulant or antiplatelet agents) or early adverse physiological features (pyrexia, hypoxia, dehydration or hyperglycaemia) are associated with progressing ischaemic stroke. Methods: The study used a case-control design. From a database of 873 consecutive acute stroke admissions, 196 cases of progressing ischaemic stroke (defined by point deterioration in components of the Scandinavian Stroke Scale or death over the first 72 h after hospital admission) were matched to 196 controls on the basis of age and stroke type. Univariate and conditional logistic regression techniques were used to explore predictors of progressing stroke. Results: Cases and controls were well matched for baseline stroke severity. Warfarin use prior to admission was associated with a reduced risk of progressing stroke [odds ratio (OR) 0.10, p = 0.005]. Prior antiplatelet use was not related. A previous history of diabetes (OR 2.11, p = 0.039) and elevated systolic blood pressure on admission (OR 1.01 for each 1 mm Hg rise, p = 0.017) predicted progressing stroke. Although there were no differences in time to presentation or to brain imaging, a visible causative lesion on CT scanning was more common in the progressing stroke group (OR 2.30, p = 0.022). We found no evidence that adverse physiological features were associated with progressing stroke. Outcomes were worse in the progressing stroke group with 70% being dead or dependent by 30 days compared to 55% in the control group (p = 0.002). Conclusion: Prior warfarin use may be protective against progressing ischaemic stroke. A previous history of diabetes along with elevated admission systolic blood pressure predict deterioration. We found no evidence for an association between adverse physiological features and progressing stroke.
Use of an Injectable Calcium Phosphate Bone Cement in the Treatment of Tibial Plateau Fractures: A Prospective Study of Twenty-Six Cases With Twenty-Month Mean Follow-Up

Objective To evaluate the potential benefit of a new injectable mineral bone cement (Norian SRS, Cupertino, CA, USA) for the treatment of tibial plateau fractures OTA types 41.B2–B3 and C3. Design Prospective study with established protocol. Setting University hospital; university teaching hospital. Patients Twenty-six patients gave informed consent to participate in this study and were available for follow-up examinations. All patients had sustained intraarticular tibial plateau fracture types OTA B2–B3 and C3. All cases were followed with a mean follow-up time of 19.7 months (6 to 36 months, median eighteen months). Intervention Twenty-five cases were treated with open reduction, osteosynthesis with screws or plate, and injection of Norian SRS in the subchondral bone defect. One case had closed reduction, screw osteosynthesis, and percutaneous cement injection. Main Outcome Measurements Radiographs in two planes were evaluated prospectively at six, twelve, and twenty-six weeks postoperatively and at last follow-up using Rasmussen's radiologic score. Clinical parameters were measured at the same time intervals using Lysholm's and Tegner's knee scores. Results Two cases required early wound revisions because of sterile drainage. Two cases developed partial loss of reduction of the fracture between four and eight weeks after surgery, requiring revision surgery in one case (total complication rate 15.3 percent). No other patients had complications, and all other fractures healed without any displacement. The high mechanical strength of the cement allowed early weight bearing after a mean postoperative period of 4.5 weeks (1 to 6 weeks). Conclusions An injectable mineral bone cement with high initial mechanical strength was used to fill bone defects in unstable tibial plateau fractures with good success. This material offers new perspectives in the treatment of tibial plateau fractures.