Miracle-dz/UniFAR-FTUs huggingface dataset:
Orbital Involvement In Sinonasal Diseases.

BACKGROUND Orbital involvement in sinonasal diseases can present as proptosis, ophthalmoplegia or even as blindness due to optic nerve damage. There are a number of sinonasal diseases which can involve eyes. The purpose of this study was to enlist diagnoses of all the patients with sinonasal disease, in which orbit was also involved unilaterally or bilaterally and to analyse the management strategy and final outcome in all the cases. METHODS Hundred consecutive patients having orbital symptoms along with sinonasal complaints that presented in ENT department of Shaikh Zayed federal postgraduate medical institute were included in our prospective study. CT scan and/or MRI were done in all the cases and ophthalmological consultation was done. Patients with sinonasal complaints without clinical involvement of orbit and those with primary orbital pathology were excluded from our study. Final diagnosis was made after histopathological confirmation. RESULTS A total of 37% of the patients were diagnosed to be having "Allergic fungal rhinosinusitis" 17% had "mucormycosis", 16% had "chronic invasive fungal sinusitis". Other pathologies identified were Nasopharyngeal CA (4%), Squamous cell Ca (4%), cavernous sinus thrombosis (3%), Adenocarcinoma (3%), Angiofibroma (2%) fibrous dysplasia (2%) and Acute complicated Rhinosinusitis (2%) Following rare pathologies were identified in only one patient each. These included Lymphoma, Osteoma, and Rhabdomyosarcoma, Transitional cell carcinoma arising from inverted papilloma, Hemangiopericytoma, Spindle cell sarcoma, Pituitary adenoma, Giant cell sarcoma, malignant undifferentiated tumour, plexiform neurofibroma and sinonasal tuberculosis. Most common orbital symptom was proptosis. Eighty-one patients had proptosis followed by 23 patients with diplopia, 22 patients with ophthalmoplegia, 16 patients with visual loss and 15 patients with ptosis. CONCLUSIONS Orbital involvement in most of the sinonasal diseases indicate extensive and aggressive nature of the pathology and many of these, even if they are not malignancies are difficult to treat. This is especially true for acute fulminant and chronic invasive fungal rhinosinusitis.
Structural changes in the labor market and the rise of early retirement in Europe

The rise of early retirement in Europe is typically attributed to the European system of taxes and transfers. Contrary to a purely neoclassical framework, a model with imperfectly competitive labor market also allows to consider the effect of the bargaining power of labor and matching efficiency on preretirement. We find that lower bargaining power of workers and less efficient labor markets characterized by the declining matching efficiency have been an important determinant of early retirement in France and Germany. These structural changes, combined with early-retirement transfers and population ageing, are also consistent with the joint evolution of employment and unemployment rates, the labor share and the seniority premium.
Economic insecurity and variations in resources

Economic insecurity is a term used to describe the uncertainty surrounding economic aspects of people’s lives. Clearly, this is a multi-faceted issue and a comprehensive formal definition that subsumes all possible aspects of it is likely to remain difficult to be agreed upon for some time to come. We characterize a class of individual economic insecurity measures based on variations in economic resources. The measures involve three easily interpretable parameters and can be computed using currently available household longitudinal data. Our proposal provides a simple and intuitively appealing criterion to assist policy makers in assessing and ameliorating economic insecurity.
Sodium restriction and blood pressure in hypertensive type II diabetics: randomised blind controlled and crossover studies of moderate sodium restriction and sodium supplementation.

OBJECTIVE--To determine the effect of moderate dietary sodium restriction on the hypertension of non-insulin-dependent (type II) diabetes. DESIGN--Randomised parallel controlled study of moderate sodium restriction for three months compared with usual diabetic diet, followed by randomised double blind crossover trial of sustained release preparation of sodium for one month versus placebo for one month in patients continuing with sodium restriction. SETTING--Patients attending diabetic outpatient clinic of city hospital. PATIENTS--Thirty four patients with established type II diabetes complicated by mild hypertension (systolic blood pressure greater than 160 mm Hg or diastolic pressure greater than 95 mm Hg on three consecutive occasions). Patients already taking antihypertensive agents (but not diuretics) not barred from study provided that criteria for mild hypertension still met. Conditions precluding patients from study were diabetic or hypertensive nephropathy, cardiac failure, and pregnancy. INTERVENTIONS--After run in phase with recordings at seven weeks, three weeks, and time zero patients were allocated at random to receive moderate dietary sodium restriction for three months (n = 17) or to continue with usual diabetic diet. Subsequently nine patients in sodium restriction group continued with regimen for a further two months, during which they completed a randomised double blind crossover trial of sustained release preparation of sodium (Slow Sodium 80 mmol daily) for one month versus matching placebo for one month. END POINT--Reduction in blood pressure in type II diabetics with mild hypertension. MEASUREMENTS AND MAIN RESULTS--Supine and erect blood pressure, body weight, and 24 hour urinary sodium and potassium excretion measured monthly during parallel group and double blind crossover studies. After parallel group study sodium restriction group showed significant reduction in systolic blood pressure (supine 19.2 mm Hg, erect 21.4 mm Hg; p less than 0.001) and mean daily urinary sodium excretion (mean reduction 60 mmol/24 h). There were no appreciable changes in weight, diabetic control, or diastolic pressure. No significant changes occurred in controls. In double blind crossover study mean supine systolic blood pressure rose significantly (p less than 0.005) during sodium supplementation (to 171 mm Hg) compared with value after three months of sodium restriction alone (159.9 mm Hg) and after one month of placebo (161.8 mm Hg). CONCLUSIONS--Moderate dietary restriction of sodium has a definite hypotensive effect, which may be useful in mild hypertension of type II diabetes.
Does Immediate Arousal Enhance Response Force in Simple Reaction Time?

Three experiments assessed the hypothesis that immediate arousal enhances response force in speeded reaction-time tasks. Immediate arousal was manipulated via the physical characteristics of a warning signal that closely preceded the imperative response signal. The first experiment revealed that responses were more forceful and faster for a loud than for a soft warning signal. The second experiment manipulated the duration of an auditory warning signal; more forceful but slower responses were obtained for longer durations of the warning signal. The third experiment employed a visual warning signal, and its intensity was either rather weak or moderately bright; more forceful responses and slightly faster responses were observed for the brighter warning signal. Although the results of Experiment 1 and 2 may agree with an arousal account, the findings of Experiment 3 argue against such an account. A stimulus-response compatibility hypothesis is suggested as one possible alternative account.
Welfare Rescaling in Italy and Spain: Political Strategies to Deal with Harsh Austerity

By looking at the main welfare state reforms undertaken by the Italian and Spanish governments since the outbreak of the financial crisis, this article explores changes resulting from the implementation of austerity policies. In light of the way in which unpopular fiscal adjustment measures have been introduced in both countries, especially since 2010, we call for a revision of the existing literature on welfare retrenchment and political strategies. We argue in this article that under conditions of ‘permanent strain’, bold retrenchment policies and cuts in social spending have been justified by the Italian and Spanish governments through a ‘there is no alternative’ or TINA legitimation strategy, which creates limited interaction space between social and political actors. We tentatively conclude that this political strategy does not entirely fit the notions of blame avoidance or credit claiming as currently formulated in the specialist literature. We call for further empirical testing of the arguments made in this paper.
Effects of Presentation Level on Phoneme and Sentence Recognition in Quiet by Cochlear Implant Listeners

Objective The objectives of this study were to characterize the effects of presentation level on speech recognition in quiet by cochlear implant users with the Nucleus 22 SPEAK and Clarion v1.2 CIS speech-processing strategies, and to relate speech recognition at low presentation levels to stimulus audibility as measured by sound field thresholds. It was hypothesized that speech recognition performance in both Nucleus SPEAK and Clarion CIS participants would decrease as presentation level was decreased below 50 to 60 dBA, due to audibility limitations. However, it was expected that such level effects would be less severe in CIS participants than in SPEAK participants because the Clarion v1.2 device encodes a wider acoustic dynamic range (up to 60 dB) than the Nucleus 22 device (30 dB). Design Performance-intensity (P-I) functions for vowels, consonants and sentences in quiet were obtained from each participant. P-I functions incorporated speech levels of 70, 60, 50, 40 and 30 dBA. Subjects used their clinical speech processor maps and adjusted the loudness (volume/sensitivity) controls on their processors so that speech presented at 60 dBA was comfortably loud. Maps were created using default clinical procedures and were not adjusted to optimize sound field thresholds. Sound field thresholds and dynamic ranges were measured for warbled pure tones with frequencies of 250 to 6000 Hz. Results Consonant and sentence recognition showed strong level effects for both SPEAK and CIS participants, with performance decreasing substantially at levels below 50 dBA in most individuals. Vowel recognition showed weaker level effects. For all three speech materials, SPEAK and CIS participants demonstrated similar mean performance at 70 dBA; however, SPEAK participants showed larger reductions in performance than CIS participants with decreasing level. Sound field thresholds were more sensitive for CIS participants than for SPEAK participants, supporting the hypothesis that performance differences were related to audibility. Conclusions Cochlear implant listeners are unable to maintain good speech recognition at low presentation levels due to reduced stimulus audibility, and this may significantly limit their ability to communicate in daily life. It is likely that audibility differences between SPEAK and CIS participants in the present study can be attributed at least partly to differences in the acoustic dynamic range used by the respective processors. However, several additional factors may have contributed to differences in audibility and perception of soft speech among individual listeners with both devices. These include the minimum and maximum electrical stimulation levels specified in participants’ maps and the speech processor sensitivity setting used for testing.
Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress.

Atherothrombotic vascular diseases, such as myocardial infarction and stroke, are the leading causes of death in the industrialized world. The immediate cause of these diseases is acute occlusive thrombosis in medium-sized arteries feeding critical organs. Thrombosis is triggered by the rupture or erosion of a minority of atherosclerotic plaques that have advanced to a particular stage of "vulnerability. " Vulnerable plaques are characterized by certain key features, such as inflammation, thinning of a protective collagenous cap, and a lipid-rich necrotic core consisting of macrophage debris. A number of cellular events contribute to vulnerable plaque formation, including secretion of pro-inflammatory, procoagulant, and proteolytic molecules by macrophages as well as the death of macrophages, intimal smooth muscles cells, and possibly endothelial cells. The necrotic core in particular is a key factor in plaque vulnerability, because macrophage debris promotes inflammation, plaque instability, and thrombosis. Plaque necrosis arises from a combination of lesional macrophage apoptosis and defective clearance of these dead cells, a process called efferocytosis. This review focuses on how macrophage apoptosis, in the setting of defective efferocytosis, contributes to necrotic core formation and how a process known to be prominent in advanced lesions--activation of ER stress signal-transduction pathways--contributes to macrophage apoptosis in these plaques.
Undifferentiated Endometrial Carcinomas Show Frequent Loss of Core Switch/Sucrose Nonfermentable Complex Proteins

Undifferentiated endometrial carcinoma is an aggressive type of endometrial carcinoma that typically presents with advanced stage disease and rapid clinical progression. In contrast to dedifferentiated endometrial carcinoma, undifferentiated carcinoma lacks a concurrent differentiated (typically low-grade endometrioid) carcinoma component, though the undifferentiated component of dedifferentiated carcinoma is similar histologically and immunophenotypically to pure undifferentiated carcinoma. We recently identified 3 mutually exclusive mechanisms of switch/sucrose nonfermentable (SWI/SNF) complex inactivation (BRG1 inactivation, INI1 inactivation or ARID1A/ARID1B co-inactivation) that are associated with histologic dedifferentiation in the majority of dedifferentiated endometrial carcinoma. In the current study, we aimed to determine by immunohistochemistry whether these patterns of SWI/SNF inactivation also occur in undifferentiated endometrial carcinomas. Of the 34 undifferentiated carcinomas examined, 17 (50%) exhibited SWI/SNF complex inactivation, with 11 tumors showing complete loss of both ARID1A and ARID1B, 5 showing complete loss of BRG1 and 1 showing complete loss of INI1. Ten of the remaining 17 undifferentiated carcinomas showed the following alterations: 5 tumors (15%) showed loss of ARID1A only with intact ARID1B, BRG1, and INI1 expression, 4 tumors (12%) showed mutated patterns of p53 staining with intact SWI/SNF protein expression, and 1 tumor (3%) harbored a POLE exonuclease domain mutation (P286R). SWI/SNF complex-inactivated tumors presented more frequently with extrauterine disease spread than those with intact expression (88% vs. 41%, respectively). In addition, patients with SWI/SNF complex-inactivated tumors had a significantly worse disease-specific survival (P=0.02). The findings here demonstrate frequent SWI/SNF complex inactivation in undifferentiated endometrial carcinomas, which has future implications regarding therapies that target chromatin remodelling and epigenetic control.
Connexin 43 coupling in bovine cumulus cells, during the follicular growth phase, and its relationship to in vitro embryo outcomes

Gap junctional coupling between cumulus cells is required for oocytes to reach developmental competence. Multiple connexins, which form these gap junctions, have been found within the ovarian follicles of several species including bovine. The aim of this study was to determine the role of connexin 43 (CX43) and its relationship to embryo development, after in vitro fertilization (IVF). Cumulus−oocyte complexes (COCs) were obtained from abattoir sourced, mixed breed, bovine ovaries. COCs were isolated from follicles ranging from 2 to 5 mm in size, representing the preselected follicle pool. Immediately after isolation, two cumulus cell biopsies were collected and stored for analysis pending determination of developmental outcomes. Using in vitro procedures, COCs were individually matured, fertilized, and cultured to the blastocyst stage. Biopsies were grouped as originating from COCs that arrested at the two‐cell stage (low developmental competence [LDC]) or having developed to the late morula/blastocyst stage (high developmental competence [HDC]), after IVF and embryo culture. The expression level of CX43 was found to be significantly higher in cumulus cells from COCs that had an HDC when compared with those that had an LDC. Moreover, the gap junctional intercellular coupling rate was significantly higher in cumulus from COCs deemed to have an HDC. Significantly higher expression of the cumulus health markers luteinizing hormone receptor and cytochrome p450 19A1 was found in the cumulus originating from oocytes with HDC, suggesting that this system may provide a mechanism for noninvasively testing for oocyte health in preselected bovine follicles.
Incidence of eating disorders in Danish psychiatric secondary healthcare 1970–2008

Objective: Is an increased focus on eating disorders during the past few decades reflected by increasing occurrence in the psychiatric health service system. Method: All first-time diagnoses of eating disorders identified in the Danish Central Psychiatric Research Register 1970–2008 constitute the present research database. Age-standardized rates per 100,000 inhabitants were calculated and autoregressive models were fitted for males and females separately as well as for in- and outpatients. Results: The incidence of eating disorders diagnosed in Danish psychiatric secondary healthcare has increased considerably during a nearly 40-year period of observation both within the general category of eating disorders and also specifically for anorexia nervosa. The steepest increase is seen within females aged 15–19 years, where the highest incidences are also found. Anorexia nervosa constitutes the vast majority of all eating disorders. Throughout the time interval investigated, the number of males, however, is negligible compared to females. Most patients are seen in outpatient services, increasing towards recent years. However, the number of patients being treated as inpatients has increased linearly through the entire four decenniums investigated. Conclusions: Changes in registration principles, public awareness and higher acceptance of mental disorders in the public is the most obvious explanation for the incidence increase of anorexia nervosa and other eating disorders. This study does not answer whether there has been an increase in true incidence in the population.
Technical Change and Income Inequality in China

The purpose of this paper was to explore the inequality–technical change relationship. Different from earlier studies, we aim to gauge the impact of technical change on the overall inequality, not just a particular component of inequality. This is achieved by establishing that the labour share of income is negatively correlated with overall inequality as indicated by the popular Gini coefficient and by modelling the labour share of income as a function of technical change. The empirical model of labour share of income is estimated using 1978–2012 provincial panel data from China. The main estimation results show that technical change in China had been mostly capital-biased. It contributed to the successive reductions in China's labour share of income and thus rapid rises in income inequality.
Inhibition of Syncytia Formation and Root-knot Nematode Development on Cultures of Excised Tomato Roots.

Two different defined growth media were used to culture aseptically the root-knot nematode, Meloidogyne incognita, on excised roots of tomato, Lycopersicon esculentum cv 'Marglobe. ' One of these media, STW, was a formulation by Skoog, Tsui, and White and the other, MS, a formulation by Murashige and Skoog. From 1 through 4 weeks, inoculated tissues were fractured to observe root infection, giant-cell formation, and nematode development with the scanning electron microscope (SEM). Four weeks after inoculation, the fresh weights of roots and developmental stages of nematodes were recorded. SEM observations indicated that roots cultured on the STW medium had normal growth and infection sites with galls that supported the development of mature females by 4 weeks. Roots cultured on the MS medium were less vigorous and had infection sites with galls containing only one to four syncytialike cells that did not support the development of mature females. Eighty percent of the larvae infecting roots cultured on the MS medium failed to develop into mature females. To determine which factor(s) affected root growth and nematode development, inoculated and uninoculated roots were grown on media consisting of different combinations of the organic and inorganic fractions of the STW and MS formulations. These experiments indicated that the organic fraction of STW was essential for normal root growth; however, the inorganic fraction of MS inhibited normal gall formation and nematode development. Further testing of the inorganic fractions revealed that the high concentration of ammonium nitrate in the MS medium was a factor that inhibited giant-cell formation and nematode development.
Severe Cardiac Autonomic Derangement and Altered Ventricular Repolarization Pave the Way to Postoperative Atrial Fibrillation

Objective Postoperative atrial fibrillation (POAF) is a frequent complication after heart surgery. It has been shown that cardiac autonomic derangement plays a significant role in the genesis of atrial fibrillation (AF) and that AF might also be promoted by altered repolarization. Thus, the aim of our study was to determine the levels of cardiac autonomic modulation and repolarization properties in patients developing POAF. Methods Seventy-nine patients scheduled for aortic and/or coronary artery bypass grafting surgery with cardiopulmonary bypass were enrolled prospectively. High-resolution 20-minute electrocardiogram recordings were obtained day before surgery to determine P, PR, QT, and QTc intervals, as well as linear (time and frequency domain) and nonlinear heart rate variability parameters (fractal dimension and detrended fluctuation analysis). QTc interval was calculated using Framingham correction. Results Twenty-nine patients developed POAF (AF group), and 50 did not (non-AF group). Groups were similar regarding demographics, surgery type, and perioperative characteristics, except for older age in the AF group. QT and QTc intervals (Framingham) were longer in the AF group [442 (44) vs 422 (28) milliseconds, P = 0.018; and 448 (44) vs 431 (24) milliseconds, P = 0.031 and P = 0.019, respectively]. Time domain heart rate variability parameter PNN50 (percentage of pairs of adjacent NN intervals differing >50 milliseconds) was higher [14% (21%) vs 8% (16%), P = 0.015], and nonlinear parameter detrended fluctuation analysis α2 was lower in the AF group [0.81 (0.21) vs 0.91 (0.20), P = 0.031]. Conclusions Profound cardiac autonomic derangement, suggestive of parasympathetic excessive modulation, exists preoperatively in patients inclined to POAF after cardiac surgery, whereby parameters PNN50 and α2 differentiated the AF from the non-AF group. Prolonged QTc intervals are associated with an increased risk of POAF.