Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards a Model of Electronic Word-of-Mouth and Its Impact on the Hotel Industry

ABSTRACT Scholars and practitioners recognize that spreading word-of-mouth can play an important role in the formation of a hotel’s image. However, the relationships among various measures of online customer engagement are relatively unknown. The present study analyzes the relationships and quantifies the impacts of various measures of online engagement including the number of online reviews, overall rating, and relative ranking. The researchers used path analysis on a sample of 178 hotels to study the relationships among relevant variables and build a model to explain the impact of such measures (Figure 2). The results reveal there is a positive direct effect of the number of reviews on a hotel’s TripAdvisor rating. A negative direct effect was found between TripAdvisor rating and a hotel’s comparative ranking. Finally, the researchers discovered that TripAdvisor rating fully mediates the relationship between the number of reviews and a hotel’s comparative ranking. This article concludes with a discussion of both the theoretical and practical implications of such findings.
Modulation of Cystathionine β-Synthase Level Regulates Total Serum Homocysteine in Mice

Elevated total plasma homocysteine is an independent risk factor in the development of vascular disease in humans. Cystathionine β-synthase (CBS) is an enzyme that condenses homocysteine with serine to form cystathionine. In this article, we describe the effects of modulating CBS activity using a transgenic mouse that contains the human CBS cDNA under control of the zinc-inducible metallothionein promoter (Tg–CBS). In the presence of zinc, Tg–CBS mice have a 2- to 4-fold increase in liver and kidney CBS activity compared with nontransgenic littermates. Transgenic mice on standard mouse chow had a 45% decrease in their serum homocysteine (12.1 to 7.2 μmol/L; P<0.0001) when zinc was added to drinking water, although zinc had minimal effect on their nontransgenic siblings (13.2 μmol/L versus 13.0 μmol/L; P=NS). Tg–CBS mice maintained on a high-methionine, low-folate diet also had significantly lower serum homocysteine compared with control animals (179 μmol/L versus 242 μmol/L; P<0.02). CBS overexpression also significantly lowered serum cysteinylglycine (3.6 versus 2.8 μmol/L; P<0.003) levels and reduced the levels of many amino acids in the liver. We also found that expression of Tg-CBS rescued the severe hyperhomocysteinemia and neonatal lethality of Cbs deletion animals. Our results show that elevating CBS activity is an effective method to lower plasma homocysteine levels. In addition, the creation of an inducible mouse system to modulate plasma homocysteine will also be useful in the study of homocysteine-related vascular disease.
D2-40: A Reliable Marker in the Diagnosis of Pleural Mesothelioma

Objective: Malignant mesotheliomas of the pleura, peritoneum and pericardium can easily be confused with either metastatic adenocarcinomas or reactive pleural lesions. D2-40, a monoclonal antibody used as a marker for seminomatous germ cell tumours and lymphatic endothelial cells, was recently described in mesothelial cells and type I but not type II pneumocytes. Method: The immunoreactivities of D2-40 in 76 lung carcinomas of different histological types (adenocarcinomas, squamous cell, small cell, and bronchioloalveolar carcinomas) were compared with those of 36 pleural epithelioid and sarcomatoid mesotheliomas and 5 specimens of chronic pleuritis. Results: While all 18 analysed epithelioid mesotheliomas displayed a strong membranous immunostaining, 18 sarcomatoid mesotheliomas showed no, or a merely faint, cytoplasmic signal, comparable with fibroblasts in chronic pleuritis. Out of all analysed lung carcinomas, 49 showed no immunoreactivity for D2-40 (64%), while the other 27 (36%) showed a focal weak to moderate and only cytoplasmic signal. Conclusions: We regard D2-40 as a valid marker in the differential diagnosis of epithelioid mesotheliomas versus pulmonary adenocarcinomas. However, this marker may not properly label sarcomatoid mesotheliomas or distinguish them from reactive pleural lesions.
Immaturity of medullary cardiorespiratory neurones leading to inappropriate autonomic reactions as a likely cause of sudden death in Rett’s syndrome

Editor,—Rett’s syndrome is a cause of intellectual disability with frequent respiratory dysrhythmia. In a survey in Great Britain, we identified episodic hyperventilation in 75%, apnoeic attacks in 70%, non-seizure vacant spells in 77%, and epileptic seizures in 70% of 191 classic cases. Of all reported deaths from Rett’s syndrome, 25% were sudden and unexpected. Certain groups of interacting neurones in the medulla perform autonomic and respiratory functions that can be measured non-invasively. With informed consent and the approval of the local ethics committee, we measured the autonomic reactions …
Brucella ribosomal protein L7/L12 is a major component in the antigenicity of brucellin INRA for delayed-type hypersensitivity in brucella-sensitized guinea pigs

A delayed-type hypersensitivity (DTH) reaction in the course of brucellosis in humans and animals can be revealed by the brucellin INRA (Brucellergen) skin test. Brucellergen is composed of more than 20 proteins of different molecular weights. A 12-kDa protein eliciting DTH in Brucella melitensis Rev1-sensitized guinea pigs was found to be a significant component for the allergenic properties of Brucellergen. Sequencing of the gene encoding this protein identified it as the L7/L12 ribosomal protein. The L7/L12 gene of B. melitensis was amplified by PCR and subcloned in the Escherichia coli pQE30 plasmid. The resulting recombinant protein did not produce a DTH reaction in sensitized animals. It was used to raise specific antibodies in a rabbit. Affinity chromatography with these antibodies was used to isolate a single protein from Brucellergen and from B. melitensis cytosol preparations which produced a DTH reaction in guinea pigs sensitized with B. melitensis Rev1. N-terminal amino acid sequencing of the protein confirmed that it was the L7/L12 ribosomal protein. This is the first complete report on the involvement of a defined bacterial ribosomal protein in the DTH response of animals infected with intracellularly multiplying bacteria.
A statistical study of EMIC waves observed by Cluster: 1. Wave properties

Electromagnetic ion cyclotron (EMIC) waves are an important mechanism for particle energization and losses inside the magnetosphere. In order to better understand the effects of these waves on particle dynamics, detailed information about the ellipticity, normal angle, energy propagation angle distributions, and local plasma parameters are required. Previous statistical studies have used in situ observations to investigate the distribution of these parameters in the L-MLT frame within a limited MLAT range. In this study, we present a statistical analysis of EMIC wave properties using ten years (2001-2010) of data from Cluster, totaling 17,987 minutes of wave activity. Due to the polar orbit of Cluster, we are able to investigate EMIC waves at all MLATs and MLTs. This allows us to further investigate the MLAT dependence of various wave properties inside different MLT sectors and further explore the effects of Shabansky orbits on EMIC wave generation and propagation. The current paper focuses on the wave occurrence distribution as well as the distribution of wave properties.
Personal Value of Alcohol Use as a Predictor of Intention to Decrease Post-College Alcohol Use

This study examines the utility of a new measure of personal value of alcohol use in predicting intentions to reduce post-college alcohol use. This measure is intended to distinguish college students who drink due to situational norms versus intrinsic commitment to alcohol use. As expected, alcohol consumption quantity/frequency and frequency of consuming five or more drinks per occasion were unrelated to intention to reduce alcohol use after college. When these alcohol consumption measures were controlled using partial correlation, the personal value of alcohol measure was significantly and negatively related to intention to reduce alcohol use. Conversely, when personal value of alcohol use was controlled in partial correlations, the relationship between alcohol consumption variables and intention to reduce alcohol use after college became positive, though only at marginally significant levels. Implications are discussed.
Determinants of Access to Formal Credit by the Poor Households

This paper investigates the determinants of access to formal credit by poor households in South Africa. Despite some progress in poverty reduction in the recent years, it remains astonishingly high by historical and international standards. Access to credit is believed by some scholars to be a primary means to address poverty and improve the standards of living of poor households. Thus, it is necessary to identify the determinants of the propensity to borrow and of the amount that is borrowed. Using 2008-2012 data from the National Income Dynamics Study (NIDS), a Heckman Selection model was estimated. The results from this study suggest that age of the household head, race, educational level, gender, employment, geographic location of households affect the propensity to borrow by poor households in South Africa.
Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-γ1

We have previously shown that systemic staphylococcal enterotoxin A (SEA) injections cause CD4 T cells in TCR-transgenic mice to become tolerant to subsequent ex vivo restimulation. An active IFN-γ-dependent mechanism of suppression was responsible for the apparent unresponsiveness of the CD4 T cells. In this study, we analyze the response of CD4 T cells isolated throughout the first 10 days of the in vivo response to injected SEA. We show that CD4 T cells isolated at the peak of the in vivo response undergo very little activation-induced cell death after sterile FACS sorting or restimulation in the presence of neutralizing Abs to IFN-γ. We also show that the IFN-γ-dependent tolerance develops soon after SEA injection in the spleens of both normal and TCR-transgenic mice. This suppression is dependent upon myeloid cells from the SEA-treated mice and is optimal when inducible NO synthase activity and reactive oxygen intermediates are both present. The data indicate that IFN-γ, myeloid cells, and a combination of NO and reactive oxygen intermediates all contribute to a common pathway of T cell death that targets activated or responding CD4 T cells. Sorted Gr-1+ cells from SEA-treated mice also directly suppress the response of naive CD4 T cells in mixed cultures, indicating that this tolerance mechanism may play a role in down-regulating other vigorous immune responses.
Isolation and characterization of a monoclonal antibody directed against type 1 fimbriae organelles from Escherichia coli

We have isolated a mouse immunoglobulin M (IgM) monoclonal antibody directed against type 1 fimbriae from the Escherichia coli K-12-derived strain CSH50. Antibody specificity was demonstrated by (i) the ability of fimbriate but not nonfimbriate bacteria to compete with solid-phase purified fimbriae for antibody binding in an enzyme-linked immunosorbent assay, (ii) the visualized binding of antibody to fimbriae alone by electron microscopy, and (iii) the appearance in a radioimmunoprecipitation assay of a single electrophoretic band comigrating with pure type 1 fimbriae. The monoclonal antibody was further characterized by immunoblot analysis and compared with previously prepared rabbit anti-fimbrial antisera. Whereas the monospecific but polyvalent antisera recognized both fimbrial monomeric subunits and non-disaggregated fimbriae organelles, the monoclonal antibody recognized only the intact organelles even when the samples were prepared under nondenaturing conditions. The monoclonal antibody, therefore, might be directed against an epitope spanning two (or more) adjacent fimbrial subunits.
Asymptotical statistics of misspecified hidden Markov models

This paper deals with the problem of modeling data generated by an ergodic stochastic process as the output of a hidden Markov model (HMM). More specifically, we consider the problem of fitting a parametric family of HMM with continuous output to an ergodic stochastic process with continuous values, which does not necessarily belong to the family. In this context, we derive the main asymptotic results: almost sure consistency of the maximum likelihood estimator, asymptotic normality of the estimation error and the exact rates of almost sure convergence.
A new isolate of hepatitis B virus from the Philippines possibly representing a new subgenotype C6

Hepatitis B virus (HBV) genotypes and subgenotypes show distinct geographical prevalence. A genotyping analysis of 28 samples from asymptomatic HBV carriers from the Philippines gave a distribution of HBV genotypes as expected from a previous study: 54% B (15/28), C5 18% (5/28), 14% D (4/28), 7% A1 (2/28). In addition, 7% (2/28) of the samples showed a double infection with genotypes B and D. One of the isolates sequenced completely, ph105, did not group into one of the known subgenotypes after phylogenetic analysis. Ph105 formed a separate clade in genotype C. With a genome length of 3,215 nt. and a serological subtype adr, ph105 exhibited the main features of most genotype C strains. However, ph105 differed by 4.1–7.2% from HBV subgenotypes C1 to C5 when comparing the nucleotide sequence of whole genomes. With only 4.1% difference ph105 was most closely related to subgenotype C2. SimPlot analysis gave no indication for recombination with known HBV genotypes. Ph105 fulfils all criteria for a new subgenotype C6. J. Med. Virol. 81:983–987, 2009. © 2009 Wiley‐Liss, Inc.
The role of Leptospira spp. in horses affected with recurrent uveitis in the UK

Summary Background Equine recurrent uveitis (ERU) is a common cause of ocular pain and blindness in horses. Leptospira spp. have been commonly implicated in the pathophysiology of ERU in mainland Europe and the USA. No recent studies have been carried out in the UK, but Leptospira is reported not to be a major factor in the aetiology of ERU in the UK. Objectives To establish the prevalence of Leptospira‐associated ERU in the UK and to identify the serovars involved in these cases; to compare serum vs. aqueous humour antibody levels in cases and controls in order to confirm the diagnosis of Leptospira‐associated ERU, and to assess the usefulness of serology alone as a confirmatory test for Leptospira‐associated ERU in the UK. Study design Case–control study. Methods Eyes enucleated for clinical reasons in ERU‐affected horses were collected. Blood and aqueous humour were obtained to determine antibody levels against a variety of Leptospira serovars and C‐values (aqueous humour value/serum value) were calculated. In addition, eyes, blood and aqueous humour were obtained from control cases for comparison. Histopathology was performed in all eyes to confirm uveitis in each case. Differences in seroprevalences between ERU and control cases and between Leptospira‐ and non‐Leptospira‐associated ERU cases were calculated. Results A total of 30 ERU and 43 control eyes were analysed. Of the ERU eyes, only two had a C‐value of >4 (prevalence of Leptospira‐associated uveitis: 6.7%). Serovars hardjo and javanica were detected. There was no difference in seroprevalence between horses with uveitis and control cases (65.5% and 41.9%, respectively; P = 0.11) or between Leptospira‐ and non‐Leptospira‐associated uveitis cases (100% and 63.0%, respectively; P = 0.52). Main limitations The study was limited by low case numbers. Eyes were presented at different stages of disease. The only test used to detect Leptospira was the microscopic agglutination test. Conclusions Leptospira‐associated ERU is uncommon in the UK. Serology alone may not help to definitively diagnose Leptospira‐associated uveitis in this country.
Computing Dominant Poles of Power System Multivariable Transfer Functions

This paper describes a numerical linear algebra algorithm to compute the dominant poies of multiinput/multioutput (MIMO) high-order transfer functions. The results presented are related to the study of electromechanical oscillations in large electric power systems, but the algorithm is completely general. The computed dominant poles may then be used to build modal equivalents for MIMO transfer functions of large linear systems, among other applications.
Monetary Policy's Rising FX Impact in the Era of Ultra-Low Rates

We show that the FX impact of monetary policy has been growing significantly. We use a high-frequency event study of the joint response of fixed income instruments and exchange rates to monetary policy news from seven major central banks spanning 2004-2015. News affecting short maturity bonds have the strongest impact, highlighting the relevance of communication regarding the path of future policy. The FX impact of monetary policy is state-dependent and is stronger the lower is the level of interest rates. A greater adjustment burden falls onto the exchange rate, as rates are increasingly constrained by the effective lower bound.
Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a meta-analysis.

OBJECTIVE Programmed cell death 1 (PD-1) and one of its ligands, PD-L1, are key immune checkpoint proteins. Evidences showed PD-L1 is an emerging biomarker for immunotherapy by anti-PD-1 and anti-PD-L1 antibody in non-small cell lung cancer (NSCLC). To investigate the association of PD-L1 protein expression with clinicopathological features and its impact on survival outcome, we conducted a meta-analysis. METHODS A comprehensive literature search of electronic databases (up to July 10, 2014) was performed. Correlation between PD-L1 expression and clinicopathological features and overall survival (OS) was analyzed by synthesizing the qualified data. Publication biases were examined. RESULTS A total of 1,550 NSCLC patients from 9 studies were included. The pooled odds ratios (ORs) indicated high PD-L1 expression was associated with poor tumor differentiation [OR =0.53, 95% confidence interval (CI): 0.39-0.72, P<0.0001]. Whereas, none of other clinicopathological characteristics [gender, smoking status, histological type, invasive depth of tumor, status of lymph node metastasis and tumor node metastasis (TNM) stage] were correlated with PD-L1 expression in current analysis. The combined hazard ratio (HR) for OS showed high expression of PD-L1 impaired the OS in NSCLC (HRpositive/negative =1.47, 95% CI: 1.19-1.83, P=0.0004). CONCLUSIONS Our meta-analysis indicated PD-L1 protein expression in NSCLC was not associated with common clinicopathological characteristics, except tumor differentiation. It was a poor prognostic biomarker for NSCLC. Further research should be performed to investigate the precise clinicopathological and prognostic significance of PD-L1 in NSCLC under uniform testing standard.
Can governments use Get Out The Vote letters to solve Europe’s turnout crisis? Evidence from a field experiment

Abstract Declining levels of turnout are a problem in European elections. Are Get Out The Vote campaigns the solution to the problem? While many studies have investigated such campaigns in the US, little is known about their effect in Europe. The article presents a field experiment in which encouragement to vote in an upcoming Danish election is delivered to more than 60,000 first-time voters using direct personal letters. Eight different letters are designed, based on the calculus of voting and prospect theory. The sample is randomly divided into treatment groups or the control group. Using validated turnout, small positive effects of receiving a letter on turnout are found, with little difference across letters. The letters mostly mobilised voters with a low propensity to vote and thus increased equality in participation. In sum, while letters have some effect, they are not likely to be a panacea for solving Europe’s turnout challenges.
Sleep/wake measurement using a non‐contact biomotion sensor

We studied a novel non‐contact biomotion sensor, which has been developed for identifying sleep/wake patterns in adult humans. The biomotion sensor uses ultra low‐power reflected radiofrequency waves to determine the movement of a subject during sleep. An automated classification algorithm has been developed to recognize sleep/wake states on a 30‐s epoch basis based on the measured movement signal. The sensor and software were evaluated against gold‐standard polysomnography on a database of 113 subjects [94 male, 19 female, age 53 ± 13 years, apnoea–hypopnea index (AHI) 22 ± 24] being assessed for sleep‐disordered breathing at a hospital‐based sleep laboratory. The overall per‐subject accuracy was 78%, with a Cohen’s kappa of 0.38. Lower accuracy was seen in a high AHI group (AHI >15, 63 subjects) than in a low AHI group (74.8% versus 81.3%); however, most of the change in accuracy can be explained by the lower sleep efficiency of the high AHI group. Averaged across subjects, the overall sleep sensitivity was 87.3% and the wake sensitivity was 50.1%. The automated algorithm slightly overestimated sleep efficiency (bias of +4.8%) and total sleep time (TST; bias of +19 min on an average TST of 288 min). We conclude that the non‐contact biomotion sensor can provide a valid means of measuring sleep–wake patterns in this patient population, and also allows direct visualization of respiratory movement signals.
Comparison of two rapid microscopic methods and culture for detection of Chlamydia trachomatis in ocular and nasopharyngeal specimens from infants

The data available for the diagnosis of chlamydial infections in infants which compare direct fluorescent-monoclonal-antibody stains (DFAs) with culture are limited to one reagent, MicroTrak (Syva Inc., Palo Alto, Calif.). We therefore performed a comparison of Pathfinder (Kallestad Diagnostics, Chaska, Minn.) and MicroTrak with chlamydia culture. Paired conjunctival and nasopharyngeal specimens for DFAs and cultures were obtained from 56 infants less than 1 month of age with conjunctivitis. The sensitivities for detecting C. trachomatis in conjunctival specimens with MicroTrak and Pathfinder were 93.8 and 88.2%, respectively, and the specificities were 87.5 and 94.9%, respectively. The DFA tests on nasopharyngeal specimens from infants with conjunctivitis did not perform as well. The sensitivities for Pathfinder and MicroTrak were 33 and 50%, respectively. There were a total of six patients with culture-positive chlamydial conjunctivitis whose nasopharyngeal specimens were DFA positive and culture negative; four of the specimens were positive by both DFAs. These six discordant specimens were further evaluated by preparing pellets and smears of the original culture specimens. All six contained typical fluorescing elementary bodies when stained with the Syva DFA reagent.