Miracle-dz/UniFAR-FTUs huggingface dataset:
First‐year mortality rates for selected birth defects, Hawaii, 1986–1999

Birth defects have been the leading cause of infant death in the United States for over the last decade. However, there is little population‐based data on the first‐year mortality rates for many specific birth defects and the factors that may affect these mortality rates. This investigation examined the first‐year mortality rates for 54 selected birth defects of various organ systems in Hawaii during 1986–1999 using data from a population‐based birth defects registry and evaluated the impact of the presence of chromosomal abnormalities and other structural birth defects and the year of delivery on the mortality rates. Mortality rates varied widely by defect, being highest for anencephaly (100%), trisomy 13 (82%), and trisomy 18 (74%), while no first‐year deaths were reported for glaucoma, bladder exstrophy, and persistent cloaca. The majority (36 of 54 or 67%) of the birth defects had a mortality rate of less than 25%. Among the 51 structural birth defects, 38 (75%) had higher first‐year mortality rate for cases with chromosomal abnormalities and 42 (82%) had higher first‐year mortality rates for cases with other major structural birth defects. The mortality rate among 1986–1992 deliveries was higher than the mortality rate among 1993–1999 deliveries for 37 (69%) of the 54 birth defects. This study indicates that first‐year mortality rates vary widely by type of birth defect, although the mortality rate for the majority of birth defects is relatively low. The presence of a chromosomal abnormality or other structural birth defect increases the mortality rate, and mortality rates for the majority of birth defects have declined in Hawaii during the study period. © 2003 Wiley‐Liss, Inc.
Adrenal Involvement in Polycystic Ovary Syndrome

The etiology of hyperandrogenic chronic anovulation is heterogeneous and relatively unknown in the majority of cases. Affected individuals in this latter segment are considered to have polycystic ovary syndrome (PCOS) of which 50 to 60% exhibit androgen excess of adrenal origin. An understanding of normal adrenal function provides insight into the factors that contribute to adrenal androgen excess in PCOS. Since pituitary ACTH secretion promotes developmental growth and overall steroidogenic efficiency within the adrenal cortex, it is probable that these actions of ACTH along with the adrenal's unique centripetal circulation play a major role in the induction of adrenarche. This latter phenomenon is characterized by alterations in adrenocortical morphology and steroidogenic enzyme activities culminating in increases in adrenal androgens to normal circulating adult levels. Thus, it is not surprising that adrenal dynamic testing has revealed increased 17,20 lyase activity or adrenal androgen hyper-responsiveness to ACTH as the two abnormalities leading to adrenal androgen excess in PCOS. Whereas 17,20 lyase hyperactivity diagnosed by defined criteria in response to pharmacological ACTH may be an intrinsic genetic defect, increases in 17,20 lyase activity and adrenal androgen hyper-responsiveness to ACTH in response to physiological ACTH may be promoted by the functional elevation of estrogen of ovarian origin in PCOS. The latest in vitro data suggest the estrogen may elicit its effect on the adrenal cortex through a receptor mediated mechanism. Therefore, the currently available data indicate that adrenal androgen excess in PCOS is also heterogeneous in etiology.
Timescale of material circulation in subduction zone: U–Pb zircon and K–Ar phengite double‐dating of the Sanbagawa metamorphic complex in the Ikeda district, central Shikoku, southwest Japan

We have estimated the timescale of material circulation in the Sanbagawa subduction zone based on U–Pb zircon and K–Ar phengite dating in the Ikeda district, central Shikoku. The Minawa and Koboke units are major constituents of the high‐P Sanbagawa metamorphic complex in Shikoku, southwest Japan. For the Minawa unit, ages of 92–81 Ma for the trench‐fill sediments, are indicated, whereas the age of ductile deformation and metamorphism of garnet and chlorite zones are 74–72 Ma and 65 Ma, respectively. Our results and occurrence of c. 150 Ma Besshi‐type deposits formed at mid‐ocean ridge suggest that the 60‐Myr‐old Izanagi Plate was subducted beneath the Eurasian Plate at c. 90 Ma, and this observation is consistent with recent plate reconstructions. For the Koboke unit, the depositional ages of the trench‐fill sediments and the dates for the termination of ductile deformation and metamorphism are estimated at c. 76–74 and 64–62 Ma, respectively. In the Ikeda district, the depositional ages generally become younger towards lower structural levels in the Sanbagawa metamorphic complex. Our results of U–Pb and K–Ar dating show that the circulation of material from the deposition of the Minawa and Koboke units at the trench through an active high‐P metamorphic domain to the final exhumation from the domain occurred continuously throughout c. 30 Myr (from c. 90 to 60 Ma).
Increase of urinary 5-hydroxyindoleacetic acid excretion but not serum chromogranin A following over-the-counter 5-hydroxytryptophan intake.

BACKGROUND 5-hydroxyindoleacetic acid (5-HIAA) excretion is commonly measured for biochemical detection of carcinoid tumours. A 77-year-old woman was referred for elevated 24 h urine 5-HIAA excretion (510 micromol/day; normal is less than 45 micromol/day) and serum chromogranin A (CgA) (72.1 U/L; normal is less than 18 U/L), both subsequently normalized after discontinuation of 5-hydroxytryptophan (5-HTP). 5-HTP, a precursor of serotonin, is not commonly listed as a substance that increases 5-HIAA levels in urine. The effect of 5-HTP on CgA has not been previously described. OBJECTIVES To determine whether, and to what extent, oral 5-HTP increases urine 5-HIAA excretion and serum CgA levels in healthy volunteers. PATIENTS AND METHODS A randomized, prospective, double-blind, placebo-controlled crossover study, with a four-day washout period, was performed in a general community setting. Eight healthy subjects aged 22 to 58 years were recruited by advertising. Bedtime ingestion of 5-HTP 100 mg/day was compared with placebo ingestion for 10 days. Twenty-four hour urine excretion of 5-HIAA and serum CgA were the main outcome measures. RESULTS Median (range) urinary 5-HIAA excretion was 204 micromol/day (22 micromol/day to 459 micromol/day) during 5-HTP intake, compared with 18 micromol/day (12 micromol/day to 36 micromol/day) during placebo intake (P=0.017). 5-HTP did not affect clinical symptoms or serum CgA levels. CONCLUSIONS Oral 5-HTP increases urinary 5-HIAA excretion with considerable interindividual variation. In a small number of subjects, oral 5-HTP did not affect serum CgA levels. Therefore, increased 5-HIAA levels with normal CgA levels may suggest 5-HTP ingestion. The use of over-the-counter 5-HTP should be excluded as the cause of increased urinary 5-HIAA levels before initiating diagnostic tests to search for a carcinoid tumour. 5-HTP should be added to popular references as a substance that may cause increased 5-HIAA excretion.
Learning with Noisy and Trusted Labels for Fine-Grained Plant Recognition

The paper describes the deep learning approach to automatic visual recognition of 10 000 plant species submitted to the PlantCLEF 2017 challenge. We evaluate modifications and extensions of the state-ofthe-art Inception-ResNet-v2 CNN architecture, including maxout, bootstrapping for training with noisy labels, and filtering the data with noisy labels using a classifier pre-trained on the trusted dataset. The final pipeline consists of a set of CNNs trained with different modifications on different subsets of the provided training data. With the proposed approach, we were ranked as the third best team in the LifeCLEF 2017 challenge.
A unified Lyapunov function for finite time stabilization of continuous and variable structure systems with resets

A unilaterally constrained perturbed double integrator system is studied in this paper. The aim is to establish uniform finite time stability of the non-linear dynamics in the presence of impacts due to the constraints on the position variable. A non-smooth transformation is utilized to first transform the system into a variable structure system that can be studied within the framework of a conventional discontinuous paradigm. Then, a finite time stable continuous controller is used and stability of the closed-loop dynamics is proven by identifying a new set of Lyapunov functions. The results enable continuous and discontinuous cases to be unified using one parameter that defines the set of Lyapunov functions for each case.
Measuring quality of life in patients with schizophrenia:an overview

Quality of life (QoL) is of great importance to patients with schizophrenia and their families. Although the use of QoL measures may contribute to better adherence to therapeutic interventions, more satisfaction with care, improved health outcomes and reduction of health costs, QoL assessment remains underutilized in clinical practice. In this review, the authors propose a reflection on the limitations and lack of impact of QoL measures in clinical care. Our argument is based on three challenges regarding conceptual aspects and metrics, use and limits and the usefulness of measuring QoL. For each challenge, the authors have suggested pragmatic proposals and new research directions to promote the use of QoL measures in the future. These avenues of research involve a shared responsibility between QoL researchers, the medical community and decision makers. Close collaboration between all parties is necessary to promote the use of QoL measures in schizophrenia.
Influence of solar eclipse on seawater

Eclipse induced changes in solar radiation is a common interest of scientists all over the world. The disturbance of the heat balance along the supersonic travel of the trajectory of the Moon’s shadow could generate gravity waves during solar eclipse, which results a reduction in the concentration of ozone layer in the stratosphere. We, in this context, conducted some experiments to detect the possible radiations reaching the surface of the earth and the impact of such radiation in seawater during the recent total and annular solar eclipses. This is the first time that the variation in pH value of seawater during solar eclipse is examined, and the experimental data demonstrated that the solar eclipse phenomenon affects the pH value of seawater due to the shorter wavelength radiations received on the surface of the earth. The reduction is around 20% and 40% of the difference between ordinary water and seawater during total and annular eclipses respectively. The multidisciplinary influences of these findings are addressed.
The need for early angiographic embolization in blunt liver injuries.

BACKGROUND Although nonoperative management of blunt liver injury (BLI) has become standard practice, adjuncts to nonoperative therapy, such as angiographic embolization, have not been well characterized. METHODS Patients with BLI were retrospectively identified at our American College of Surgeons-verified Level I trauma center from January 1997 through February 2001. Patients were stratified into four groups: those who received angiographic embolization (AE) as an early intervention when BLI was initially diagnosed (EARLY-AE); those who underwent AE after liver-related operation or later in the hospital course (LATE-AE); those treated with operation only (OR-ONLY); and nonoperative patients who also did not undergo AE (NO-OR). RESULTS There were 126 patients with BLI, of whom 94 were NO-OR, 20 were OR-ONLY, 6 had LATE-AE, and 6 had EARLY-AE. The NO-OR group had significantly lower liver Abbreviated Injury Scale scores. Liver Abbreviated Injury Scale scores were not different between the EARLY-AE, LATE-AE, and OR-ONLY groups. Liver-related mortality was not lower for those treated with AE. There was a trend toward lower mortality for just the EARLY-AE group compared with the LATE-AE and OR-ONLY groups (0% vs. 50% and 35%). The number of units of packed red blood cells transfused and the number of liver-related operations were lower in the EARLY-AE compared with the LATE-AE group, but liver-related complications were not different between the EARLY-AE, LATE-AE, or OR-ONLY groups. AE was successful in arresting hemorrhage in 83% of the cases. CONCLUSION In this small series, we observed similar morbidity and mortality with AE compared with operative therapy. EARLY-AE did decrease blood use and the number of liver-related operations. AE can be performed on severely injured patients with comparable liver-related mortality and complications. Further study of the timing of and outcomes from AE is needed.
Trends in the coverage of ‘universal’ child health reviews: observational study using routinely available data

Objectives Universally offered child health reviews form the backbone of the UK child health programme. The reviews assess children's health, development and well-being and facilitate access to additional support as required. The number of reviews offered per child has been reduced over recent years to allow more flexible provision of support to families in need: equitable coverage of the remaining reviews is therefore particularly important. This study assessed the coverage of universal child health reviews, with an emphasis on trends over time and inequalities in coverage by deprivation. Design Assessment of the coverage of child health reviews by area-based deprivation using routinely available data. Supplementary audit of the quality of the routine data source used. Setting Scotland. Participants Two cohorts of around 40 000 children each. The cohorts were born in 1998/1999 and 2007/2008 and eligible for the previous programme of five and the current programme of two preschool reviews, respectively. Outcome measures Coverage of the specified child health reviews for the whole cohorts and by deprivation. Results Coverage of the 10 day review is high (99%), but it progressively declines for reviews at older ages (86% for the 39–42 month review). Coverage is lower in children living in the most deprived areas for all reviews, and the discrepancy progressively increases for reviews at older ages (78% and 92% coverage for the 39–42 month review in most and least deprived groups). Coverage has been stable over time: it has not increased for the remaining reviews after reduction in the number of reviews provided. Conclusions The inverse care law continues to operate in relation to ‘universal’ child health reviews. Equitable uptake of reviews is important to ensure maximum likely impact on inequalities in children's outcomes.
The burden of community-acquired pneumonia in Spain.

BACKGROUND Community-acquired pneumonia accounts for a large number of hospitalizations and deaths in developed countries. METHODS Data for Spain were obtained from the national surveillance system for hospital data and comprises all hospital discharges for pneumonia reported during a two-year period. RESULTS The annual incidence of hospitalization for pneumonia was 160 per 100,000 population. Incidence of hospitalization, mortality, average length of stay and case-mortality rate were higher in persons > or = 65 years of age. The annual cost of these hospitalizations was 115 million ECUs (1 ECU = 1.19 US Dollars). CONCLUSION Community-acquired pneumonia accounts for 53,000 hospitalizations per year in Spain, and this imposes a large economic cost on the National Health-care System.
Developing Online Dispute Resolution for Consumers in the EU: A Proposal for the Regulation of Accredited Providers

This paper evaluates the development of online dispute resolution (ODR) methods in resolving small value disputes arising out of e-commerce transactions and the need for designing a regulatory model to realise its full potential in the EU. The paper proposes the drafting of a European Regulation in the field of ODR that would set legal standards for mandatory ODR. The proposed Regulation would create a pan-European trustmark that would be granted to those ODR providers that comply with its legal provisions. Compliance would be monitored by the co-operation between national and regional authorities through the European Consumer Centres Network (ECC-Net). The ECC-Net national offices and online businesses would refer national and cross-border disputes to accredited ODR providers. The proposed Regulation would encourage the use of consensual ODR processes as a step previous to the adjudicative processes for all accredited and mandatory ODR. Decisions will be legally binding but appealable, when appropriate, through an online procedure akin to the European Small Claims Procedure.
Environmental exposures, epigenetic changes and the risk of lupus

A dose-dependent combination of environmental exposures, estrogenic hormones and genetic predisposition is thought to be required for lupus to develop and flare, but how the environment modifies the immune system in genetically predisposed people is unclear. Current evidence indicates that environmental agents that inhibit DNA methylation can convert normal antigen-specific CD4+ T lymphocytes into autoreactive, cytotoxic, pro-inflammatory cells that are sufficient to cause lupus-like autoimmunity in animal models, and that the same changes in DNA methylation characterize CD4+ T cells from patients with active lupus. Environmental agents implicated in inhibiting T-cell DNA methylation include the lupus-inducing drugs procainamide and hydralazine, as well as diet, and agents causing oxidative stress, such as smoking, UV light exposure, and infections, which have been associated with lupus onset or disease activity. Other studies demonstrate that demethylated T cells cause only anti-DNA antibodies in mice lacking a genetic predisposition to lupus, but are sufficient to cause lupus-like autoimmunity in genetically predisposed mice and likely people, and that estrogens augment the disease. Collectively, these studies suggest that environmental agents that inhibit DNA methylation, together with lupus genes and estrogens or endocrine disruptors, combine in a dose-dependent fashion to cause lupus flares.
Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid

Objectives Epoxygenase metabolites produced by the kidney affect renal blood flow and tubular transport function and 11,12-epoxyeicosatrienoic acid (11,12-EET) has been putatively identified as an endothelium-derived hyperpolarizing factor. The current studies were performed to determine the influence of 11,12-EET on the regulation of afferent arteriolar diameter in angiotensin II-infused hypertensive rats. Materials and methods Male Sprague–Dawley rats received angiotensin II (60 ng/min) or vehicle via an osmotic minipump. Angiotensin II-infused hypertensive and vehicle-infused normotensive rats were studied for 2 weeks following implantation of the minipump. Renal microvascular responses to the sulfonimide analog of 11,12-EET (11,12-EET-SI) and angiotensin II were observed utilizing the in-vitro juxtamedullary nephron preparation. Renal cortical epoxygenase enzyme protein levels were quantified by Western blot analysis. Renal microvessels were also isolated and epoxygenase metabolite levels measured by negative ion chemical ionization (NICI)/gas chromatography–mass spectroscopy. Results Systolic blood pressure averaged 118 ± 2 mmHg prior to pump implantation and increased to 185 ± 7 mmHg in rats infused with angiotensin II for 2 weeks. Afferent arteriolar diameters of 2-week normotensive animals averaged 22 ± 1 μm. Diameters of the afferent arterioles were 17% smaller in hypertensive rats (P < 0.05); however, arterioles from both groups responded to 11,12-EET-SI (100 nmol) with similar 15–17% increases in diameter. As we previously demonstrated, the afferent arteriolar reactivity to angiotensin II was enhanced in angiotensin II-infused animals. Interestingly, elevation of 11,12-EET-SI levels to 100 nmol reversed the enhanced vascular reactivity to angiotensin II associated with angiotensin II hypertension. Renal microvascular EET levels were not different between groups and averaged 81 ± 9 and 87 ± 13 pg/mg per 30 min in normotensive and hypertensive animals, respectively. Renal cortical microsomal levels of the epoxygenase CYP2C23 and CYP2C11 proteins were also similar in normotensive and angiotensin II hypertensive rats. Conclusions Taken together, these data support the concept that renal microvascular 11,12-EET activity and levels may not properly offset the enhanced angiotensin II renal vasoconstriction during angiotensin II hypertension.
Influence of growth paramaters on the crystallinity and stress of SiGe films grown by LPCVD

SiGe thin layers were deposited using LPCVD at different temperatures and pressures. The effect of the growth characteristics on the composition, grain growth and crystallinity were studied with the aim of maximizing the tensile stress of the films deposited. As expected, at constant reactant gas ratios, temperature had the maximum effect, with stress changing from compressive to tensile at higher temperatures. Films with high crystallinity and large grain sizes were produced at higher temperatures and higher pressures.
Realistic environmental mixtures of micropollutants in surface, drinking, and recycled water: Herbicides dominate the mixture toxicity toward algae

Mixture toxicity studies with herbicides have focused on a few priority components that are most likely to cause environmental impacts, and experimental mixtures were often designed as equipotent mixtures; however, real‐world mixtures are made up of chemicals with different modes of toxic action at arbitrary concentration ratios. The toxicological significance of environmentally realistic mixtures has only been scarcely studied. Few studies have simultaneously compared the mixture effect of water samples with designed reference mixtures comprised of the ratios of analytically detected concentrations in toxicity tests. In the present study, the authors address the effect of herbicides and other chemicals on inhibition of photosynthesis and algal growth rate. The authors tested water samples including secondary treated wastewater effluent, recycled water, drinking water, and storm water in the combined algae assay. The detected chemicals were mixed in the concentration ratios detected, and the biological effects of the water samples were compared with the designed mixtures of individual detected chemicals to quantify the fraction of effect caused by unknown chemicals. The results showed that herbicides dominated the algal toxicity in these environmentally realistic mixtures, and the contribution by the non‐herbicides was negligible. A 2‐stage model, which used concentration addition within the groups of herbicides and non‐herbicides followed by the model of independent action to predict the mixture effect of the two groups, could predict the experimental mixture toxicity effectively, but the concentration addition model for herbicides was robust and sufficient for complex mixtures. Therefore, the authors used the bioanalytical equivalency concept to derive effect‐based trigger values for algal toxicity for monitoring water quality in recycled and surface water. All water samples tested would be compliant with the proposed trigger values associated with the appropriate guidelines. Environ Toxicol Chem 2014;33:1427–1436. © 2014 SETAC