Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimente zur Generierung einer knockout Maus für Untersuchungen zur Funktion des Plasmodium chabaudi induzierbaren imap38 Gens

Das imap38 Gen wurde fruher in unserem Labor durch differenzielles ? screening? identifiziert und charakterisiert. Imap38 gehort zur Familie der AIG-ahnlichen Proteine, welche in Mausen, Ratten, Menschen und Pflanzen gefunden wurden. AIG-ahnliche Gene aus Saugetieren sind sehr konservativ in ihrer Struktur. Die Funktionen anderer Gene der Familie sind noch nicht genau bekannt. ian1 nimmt Teil an der Differenzierung der T-Zellen. ian4 spielt auch eine wichtige Rolle wahrend der Apoptose von T-Zellen. Man vermutet, dass imap38 wichtig bei der Heilung von Malaria Infektionen ist. Es wurde gezeigt, dass imap38 wahrend der Malaria Infektion induziert wird und sogar 13 Wochen nach der Infektion auf einem hohem Niveau exprimiert wird. Die Expression des imap38 Gens wurde in der Milz der Maus in Makrophagen und B-Zellen, sehr niedrig in T-Zellen nach der Plasmodium chabaudi Infektion bestimmt. Wahrend P53-vermittelten Apoptose in Kulturen der myeloiden leukamischen Zellinie LTR6 der Maus wurde eine sechsfache Uberexpression von imap38 ermittelt. Keine Stimulierung fuhrte zur Induzierung von imap38 in Milzzellen in vitro oder ex vivo. Diese Arbeit wurde durchgefuhrt um eine imap38-knockout Maus zu generieren, die als ein Werkzeug fur Untersuchung der Funktion von imap38 in vivo dient. Die Untersuchung der Funktion von imap38 kann die kenntnisse uber Immunantworten gegenuber der Malaria verbessern und dadurch einen Fortschritt in die Antimalariaforschung bringen. Der Mausstamm C57BL/6 wurde als Modell fur Knockout ausgewahlt, weil er P. chabaudi Malaria uberlebt, immun wird und imap38 wahrend der akuten Phase und auch nach der Infektionsheilung auf einem hohen Niveau exprimiert. Imap38 hat eine typische fur AIG ahnliche Gene Struktur. Es besteht aus zwei kleinen Exonen und einem dritten grosten Exon, die mit 2 bzw. 1 kbp grosen Intronen von einander getrennt sind. Der N-terminus des IMAP38 ist in 43 bp vom zweiten Exon kodiert. Es enthalt weder Signalsequenzen noch funktionelle Domanen. Die Entfernung des grosten Exons, das ein ATP-Bindungsmotiv und eine Transmembranedomane kodiert, war das Ziel des Targeting. Eine verbesserte, klassische Targeting Strategie wurde realisiert. Eine Cre-vermittelte Rekombination wurde fur das Ausschneiden des Resistenzmarkers zusammen mit Cre Rekombinase Genen wahrend Spermatogenese benutzt. Es wurde ein Targeting Vektor (replacement type) konstruiert, der eine selbst-ausschneidende ACN-Kassette enthalt. Sieben embryonale Stammzellklone mit einem targeted Allel wurden generiert und in CB20, NMRI, C57BL/6×129sv und c2J Blastozysten injiziert. Es wurden 13 Chimeren gewonnen. Von 241 analysierten Nachkommen der Chimeren hatte keiner ein deletiertes Allel. Mogliche Grunde und Perspektiven werden diskutiert. Die Verwendung der alternativen Methode zur Herstellung einer imap38-knockdown Maus mittels RNAi konnte die gewunschten imap38-defizienten Mause generieren.
The Analysis of Dividend Announcement Impact on Stock Prices of Baltic Companies

The paper is aimed to analyze and evaluate the dividend announcement impact on stock prices of companies listed on the NASDAQ OMX Baltic market during 2010-2015. The analysis was performed using the market model event study analysis and calculating AARs based on 3 strategies, which assume that investors buy shares 30 days prior to the dividend announcement and sell them either 1, 3 or 7 days after the dividend announcement. During the research period, dividends were paid by 40 out of 72 companies listed on the NASDAQ OMX Baltic. A total of 168 dividend announcements have been made and analyzed in this paper. The results of the research revealed that within the analyzed event windows, positive AARs exist; however, they are not statistically significant. Positive AARs obtained 3 or 7 days after the dividend announcement imply that stock prices do not drop shortly after the dividend announcement, which would indicate weak NASDAQ OMX Baltic market efficiency.
Changes in protein profile and RNA content of Apis mellifera worker pupa on parasitization with Tropilaelaps clareae

Tropilaelaps infestation of Apis mellifera pupa caused reduction in total protein concentration of the infested pupa. This may be due to protein feeding by mite. The additional protein fractions observed by SDS-PAGE and the difference in the nature of free amino acids suggested synthesis of newer proteins perhaps related to the stress response of the host. This opinion is strengthened by the increase in concentration of RNA ( 184.580Â±36.987 in non-infested pupa and 293.402Â±50.329 in infested pups) observed in the present study which was responsible for increased transcription of genes encoding antiparasite peptides as reported by other workers.
Finite Element Solution for Thermal Shock Phenomenon in Multilayered Cylindrical Bodies

General finite element (F.E.) coupled transient-dynamic model of three layers cylinder in polar coordinates under stress plane assumption, will be introduced and discussed. We have found through an analytical analysis and literature comparison that four main factors might affect the solution qualitative and quantitative behavior: (1) Temperature-stress boundary conditions, (2) Model size and length, (3) Number of layers, and (4) Materials properties in each layer. Finally, good qualitative agreement was found between the F.E. analysis results and the relevant literature for the radial displacement, the tangential and radial stresses
Antioxidant activity of bioactive extracts obtained from rhizomes of Cyperus digitatus Roxb.

Los miembros de la familia Cyperaceae, tales como Cyperus alopecuroides, Cyperus articulatus, Cyperus scariosus y Cyperus rotundus poseen una cantidad significativa de estudios sobre sus actividades antioxidantes y otras propiedades. Sin embargo, la planta Cyperus digitatus perteneciente al genero Cyperus carece de estudio de cualquier tipo de actividad intrinseca. Razon por la cual se estudio sus propiedades antioxidantes (FRAP, DPPH y blanqueamiento del β-caroteno), cuantificacion de contenido fenolico y flavonoides totales en extractos y fracciones obtenidos de los rizomas de Cyperus digitatus, y un perfil fitoquimico. De todos los extractos obtenidos, BE y AqE mostraron el mejor potencial antioxidante, por otra parte ninguna de las fracciones obtenidas a partir del extracto EAE mostro una actividad relevante
EXPERIMENTAL STUDY ON SHEAR BEHAVIOR OF PP-ECC BEAMS WITH DIFFERENT STIRRUP RATIOS

Title EXPERIMENTAL STUDY ON SHEAR BEHAVIOR OF PP-ECC BEAMS WITH DIFFERENT STIRRUP RATIOS Author(s) ZHANG, R. ; MATSUMOTO, K. ; NIWA, J.; HIRATA, T. ; ISHIZEKI, Y. Citation Proceedings of the Thirteenth East Asia-Pacific Conference on Structural Engineering and Construction (EASEC-13), September 11-13, 2013, Sapporo, Japan, B-5-5. , B-5-5 Issue Date 2013-09-11 Doc URL http://hdl.handle. net/2115/54260 Type proceedings Note The Thirteenth East Asia-Pacific Conference on Structural Engineering and Construction (EASEC-13), September 1113, 2013, Sapporo, Japan. File Information easec13-B-5-5.pdf
An investigation into unit design for developing undergraduate independent learning abilities

Many universities aspire to produce graduates who are independent learners. This paper describes explorations into what independent learning means and how it can be developed in practice within the typical resources of a standard undergraduate unit. The paper proposes techniques for advancing students along the path to independent learning and describes how these techniques have been applied in practice, including pragmatic observations on the techniques. Given the absence of clear methods for assessing independent learning, qualitative focus groups were conducted based around questions related to student perceptions of their learning and experience. These perceptions are being explored in an ongoing research investigation into a hybrid content-based/projectbased final year undergraduate unit, designed to improve the development of students’ independent learning. Some initial evaluation outcomes are presented and discussed, along with lessons learned in relation to conducting the focus groups. One interesting finding is that students were positive about their learning experience despite the unfamiliar class structure and their recognition of challenging material and strict marking. We conclude by describing how we are approaching our on-going investigation along with some possibilities for future research.
Transitioning in higher education: an exploration of psychological and contextual factors affecting student satisfaction

Abstract In view of recent changes in the higher education sector, such as increased tuition fees, a greater focus has been placed on widening participation initiatives and monitoring student satisfaction. The aims of the current study were twofold: (1) to explore whether pre-entry programmes foster successful transition to higher education, and (2) to examine longitudinally the factors associated with course satisfaction. Eighty-eight first-year psychology students completed a questionnaire measuring academic self-efficacy, social identity and student satisfaction at the start (Time 1, November 2015) and end (Time 2, March 2016) of the academic year. Findings indicated that students who participated in a pre-entry programme reported higher academic self-efficacy and satisfaction compared to typical route students. Moreover, academic self-efficacy predicted student satisfaction at the start of the academic year, whereas in-group affect (a facet of social identity) predicted this at the end of the academic year. The current findings indicate that pre-entry programmes may have a positive impact on students’ sense of academic self-efficacy. On a more general level, the findings also suggest that academic self-efficacy and social identity may be key indicators of student satisfaction. This highlights the complexities of the concept of ‘student satisfaction’, and demonstrates the utility of examining multiple factors relating to student satisfaction across different time points.
Determinants of Nutrition Label Use among Turkish Consumers

The purpose of this study is to examine the various factors that affect Turkish consumers‟ use of nutrition labels. Data was collected from a total of 500 consumers living in Istanbul through the use of a structured and undisguised questionnaire. Unlike previous research, hypotheses regarding „gender‟, „marital status‟, „preschool child ownership‟, „working status‟, „time pressure‟, „nutrition knowledge‟, „importance given to price‟, and „awareness of diet-disease relation‟ all yielded insignificant results. Again, contrary to most of the earlier studies, the direction of the relationship in case of „age‟ and „income‟ was negative rather than positive. It seems that different aspects of “concern about, interest in, and importance given to health and nutritious eating” are influential in nutrition label use in the Turkish market. Although the findings of the study pertain to the Turkish market, its implications may be applicable in other countries, as well, where nutrition labeling is not mandatory for the time being.
INVESTIGATION THE EFFECT OF HYPOTHYROIDISM ON HEMATOLOGICAL PARAMETERS

Aim: To investigate impact of the hypothyroidism on hematological parameters. Material and Method: Twenty patients with hypothyroidism and twenty two healthy subjects were enrolled in this study between February 2015 and July 2015. We collected clinical and laboratory data of patients with hypothyroidism and randomized healthy subject’s from the Adiyaman University Medical Faculty Hospital records retrospectively. The patients with anemia, rheumatic diseases, chronic kidney diseases, chronic liver diseases, chronic obstructive pulmonary disease, chronic heart diseases, inflammatory bowel diseases, malignancy and acute infections were excluded from the study. Patients were divided into two groups; hypothyroid group and healthy group. TSH values were increased in all of the hypothyroid patients. We compared hematological parameters consist of hemoglobin, platelet count, white blood cell (WBC), red cell distribution width (RDW) and mean platelet volume (MPV) between the two groups. Results: 70% of patients with hypothyroidism were female and 30% of patients were male. Mean age of patients with hypothyroidism were 44,8±13,4. 72,7% of healthy subjects were female and 27,3% of healthy subjects were male. Mean age of healthy subjects was 31±14,6. In the result with Independent sample T test increased RDW-CV values was significantly associated with hypothyroidism ( P value =0.01). The other hematological parameters weren’t different between the groups ( P value >0.05). Conclusion: The present study demonstrated that increased RDW values was associated with hypothyroidism. Key words: Hypothyroidism, RDW, MPV
Analysis of hydrogen in olivine by SIMS: Evaluation of standards and protocol

Abstract We measured hydrogen concentrations in 12 olivines using secondary ion mass spectrometry (SIMS and NanoSIMS), cross-calibrated against Fourier transform infrared (FTIR) spectroscopy and nuclear reaction analysis (NRA). Five of these samples are routinely used for calibration in other laboratories. We assess the suitability of these olivines as standards based on over 300 SIMS analyses, comprising 22 separate calibrations. Seven olivines with 0-125 ppm H2O give highly reproducible results; in contrast to previous studies, the data are fit to well-constrained calibration lines with high correlation coefficients (r2 = 0.98-1). However, four kimberlitic megacrysts with 140-245 ppm H2O sometimes yield 16O1H/30Si ratios that have low internal precision and can vary by up to a factor of two even in sequential analyses. A possible cause of this behavior is the presence of sub-microscopic inclusions of hydrous minerals, such as serpentine. In most cases, however, we link the anomalous results to the presence of sub-micrometer to micrometer-scale pores (as small as 100 nm), which we imaged using SEM and NanoSIMS. These pores are interpreted to be fluid inclusions containing liquid H2O, other volatiles (including fluorine), and/or hydrous phase precipitates. Ionization of the contents of the pores contributes variably to the measured 16O1H, resulting in analyses with erratic depth profiles and corresponding high uncertainties (up to 16%, 2σmean). After filtering of these analyses using a simple criterion based on the error predicted by Poisson counting statistics, all the data fit well together. Our results imply that the Bell et al. (2003) calibration can be applied accurately to all olivines with IR bands from -3400-3700 cm-1, without the need for band-specific IR absorption coefficients.
‘For Richer, for Poorer’: Assortative Mating and Savings Preferences

Do couples share the same values? The social sciences have mainly concentrated on comparing the socioeconomic characteristics of spouses, but rarely consider their attitudes to risk and time. In this paper, we use conventional measurements and an original method of scoring. We find that spouses are very similar in their savings preferences, even when we control for the individual characteristics. Our results suggest that most of this relationship comes from marital sorting. These conclusions are decisive in explaining the decision process within households and its implications for wealth inequalities between households since homogamy causes a divide in the population.
Outcomes - Based Evaluation of the Transformative Learning Design in Environmental Science Course of De La Salle Lipa

Environmental Science is one of the General Education subjects among college students that focuses on preservation and conservation of biological and physical aspects of the natural world by emphasizing problems and corresponding solutions. To understand these concepts and to demonstrate the Expected Lasallian Graduate Attributes (ELGAs) such as developing students to become critical thinkers, excellent communicators and socially responsible citizens, the transformative learning design was employed. Thus, this study aimed to evaluate the outcomes of employing the said design specifically in the attainment of ELGAs. This study used descriptive method of research with the aid of the questionnaire checklist and unstructured interview to assess students' perception regarding the level of attainment of the three expected learning outcomes among purposively sampled students who were enrolled in Environmental Science course during the SY 2010-2011 and 2011-2012. Based on the results of this study, an action plan for 2012 – 2013 and guideline for transformative learning were proposed.
Adaptive output-feedback servocompensator design using high-gain scaling

The error-feedback servomechanism problem is addressed for a general class of strict-feedback-like systems. The design is based on our recent results on adaptive output-feedback based on dynamic dual high-gain scaling. The design technique provides strong robustness properties and allows the system to contain both unknown functions dependent on all states and uncertain parameters coupled with all states (with no a priori magnitude bounds required on uncertain parameters).
Quantifying seasonal air-sea gas exchange processes using noble gas time-series: A design experiment

A multi-year time-series of measurements of five noble gases (He, Ne, Ar, Kr, and Xe) at a subtropical ocean location may allow quantification of air-sea gas exchange parameters with tighter constraints than is currently available by other methods. We have demonstrated this using a one-dimensional upper ocean model forced by 6-hourly NCEP reanalysis winds and heat flux for the Sargasso Sea near Bermuda. We performed ensemble model runs to characterize the response of the modeled noble gas saturation anomalies to a range of air-sea gas exchange parameters. We then used inverse calculations to quantify the sensitivity of the parameters to hypothetical observations. These calculations show that with currently achievable measurement accuracies, noble gas concentrations in the Sargasso Sea could be used to constrain the magnitude of equilibrium gas exchange to 11%, the magnitude of the total air injection flux to 14%, and the magnitude of net photosynthetic oxygen production to 1.5 mol O2 m -2 y -1 . Additionally, we can use noble gases to quantify the relative contributions of bubbles that are partially dissolved to bubbles that are completely dissolved. These constraints are based on idealized assumptions and may not fully account for some of the uncertainties in the meteorological data, in lateral transport processes, and in the solubilities of the noble gases. As a limited demonstration, we applied this approach to a time series of He, Ne, Ar, and O2 measurements from the Sargasso Sea from 1985 to 1988 (data from Spitzer, 1989). Due to the limited number of gases measured and the lower accuracy of those measurements, the constraints in this example application are weaker than could be achieved with current capabilities.
Spatial distribution of lead in Amaonye Forest soils of Ishiagu Communities in Ebonyi State of Nigeria

Geostatistical technique was applied to study the spatial distributions of lead (Pb) in Amaonye forest soil of Ishiagu communities in Ebonyi State, Nigeria. A total of 605 soil samples were collected at depths of 10, 20, 30, 40 and 50 cm from all grid points in an area of 1km x 1km gridded at 100 m grids and were analysed for Pb concentration. Using the ArcGIS geostatistical extension, the metal distribution was modeled and shown on concentration maps. The variogram (CO/C) ratio values obtained as 0% at 10, 20 and 30 cm, 11.1% at 40 cm and 9.9% at 50 cm indicated strong spatial dependence. The study shows that the metal has irregular spatial distribution in the studied area, with the highest accumulation around the stream channel and spread in the direction of water-flow into the forest soil as influenced by the topography of the landscape.Keywords: Lead, Ishiagu, geostatistics, pollution risk
Participatory urban appraisal and its application for research on violence

This paper emphasizes the importance of conducting participatory research on violence and describes the range of participatory urban appraisal tools that can be used to do so. This includes tools that can document the perceptions of poorer groups regarding the kinds of violence (economic, social or political), the extent, causes (and the links with poverty and exclusion) and consequences of violence, as well as the strategies for coping with or reducing, it. The use of these tools is illustrated with examples drawn from the findings of research on violence in 18 low-income communities in different cities in Colombia and Guatemala. The paper also outlines a conceptual framework on violence, poverty/exclusion, inequality and social capital that can help in the research design and in analyzing the findings.
Impact of human resource practices on employee perceived performance in banking sector of Pakistan

The main endeavor of this study is to examine the relationship and nature of relationship between the employee perceived performance and human resource (HR) practices (compensation, performance evaluation, and promotion practices) in the banking sector of Pakistan. Survey of 235 banking personnel was conducted through personally administrated questionnaire to investigate the impact of HR practices on employees’ perceived performance. The relationship and nature of relationship is calculated by applying the Spearman’s correlation matrix and multiple regression analysis. The Spearman’s correlation results demonstrate that, the employee perceived performance and HR practices has the positive and significant relationship. The regression results indicate that the two HR practices: performance evaluation and promotion practices are significant but the compensation practices are not significant. Moreover, this study provides help for top-management of banking sector to design or revise their HR policies and make practices to attain high employee performance. Key words: Employee perceived performance, HR practices, banking sector, Pakistan.
Syddansk Universitet Societal costs of diabetes mellitus 2025 and 2040 forecasts based on real world cost evidence and observed epidemiological trends in Denmark

Aim: The objective is to contribute with real world evidenced economic forecasts of diabetes attributable costs in 2025 and 2040 differentiated according to patients’ morbidity status which is a novel approach within forecasting. Methods: Method of forecasting is based on an annual calendar year prediction of diabetes attributable costs by using the BOX-model, an established and tested epidemiological transition-state model. The study population includes all Danish diabetes patients presented in 2011 (N= 318,729) according to the Danish National Diabetes Register. Forecasting is based on individual patient data from 2000 to 2011 for incidence, mortality, patterns of morbidity and complication rates combined with demographic population projections from Statistics Denmark. The 2011 estimation of diabetes attributable costs were applied to the epidemiological framework. Forecasting was performed for three different epidemiological scenarios.Results: Our three epidemiological scenarios indicate that within the shorter time span increases in the prevalent population are difficult to change primarily due to the already achieved historic improvements in diabetes mortality and morbidity. These will approximately double societal costs of diabetes in the next 10 years,assuming current trends in morbidity and mortality are maintained.The resulting diabetes population will incur three times current costs in 2040.A 20% reCorresponding author.
Generalization of Khan fixed point theorem

In this paper, we study some results of existence and uniqueness of fixed points for a class of mappings satisfying an inequality of rational expressions. Our main result extends and unifies the well-known results of Khan [M. S. Khan, Rend. Inst. Math. Univ. Trieste, 8 (1976), 69–72]. c ©2017 all rights reserved.