Miracle-dz/UniFAR-FTUs huggingface dataset:
The Consistency Between Scientific Papers Presented at the Orthopaedic Trauma Association and their Subsequent Full-Text Publication

Objectives: To determine the consistency of conclusions/statements made in podium presentations at the annual meeting of the Orthopaedic Trauma Association (OTA) with those in subsequent full-text publications. Also, to evaluate the nature and consistency of study design, methods, sample sizes, results and assign a corresponding level of evidence. Data Sources: Abstracts of the scientific programs of the OTA from 1994 to 1997 (N = 254) were queried by using the PubMed database to identify those studies resulting in a peer-reviewed, full-text publication. Study Selection: Of the 169 articles retrieved, 137 studies were the basis of our study after the exclusion criteria were applied: non-English language, basic science studies, anatomic dissection studies, and articles published in non-peer-reviewed journals. Data Extraction/Synthesis: Information was abstracted onto a data form: first from the abstract published in the final meeting program, and then from the published journal article. Information was recorded regarding study issues, including the study design, primary objective, sample size, and statistical methods. We provided descriptive statistics about the frequency of consistent results between abstracts and full-text publications. The results were recorded as percentages and a 95% confidence interval was applied to each value. Study results were recorded for the abstract and full-text publication comparing results and the overall conclusion. A level of scientific-based evidence was assigned to each full-text publication. Results: The final conclusion of the study remained the same 93.4% of the time. The method of study was an observational case series 52% of the time and a statement regarding the rate of patient follow-up was reported 42% of the time. Of the studies published, 18.2% consisted of a sample size smaller than the previously presented abstract. When the published papers had their level of evidence graded, 11% were level I, 16% level II, 17% level III, and 56% level IV. Conclusions: Authors conclusions were consistent with those in full-text publications. Most studies were observational, less than half reported on the rate of patient follow-up. Many abstracts followed by publication had a smaller sample size in the published paper. Half of all studies were graded level IV evidence.
Synchronous double primary lung cancers via p53 pathway induced by heavy smoking

Differences in the histological manifestation of synchronous lung cancers are rare. Synchronous multiple primary lung cancers (SMPLC) are associated with long-term tobacco use, which could independently lead to mutations in the p53 and K-ras genes. We present the case of an 82-year-old man who smoked 30 cigarettes daily for the past 60 years. CT of the chest showed a right upper lobe mass. Bronchoscopy revealed an intra-lumen nodular lesion in the right lower lobe bronchus. The diagnoses of small cell lung carcinoma (SCLC) of the right upper lobe and non-small cell lung carcinoma (NSCLC) of the right lower lobe were confirmed by the morphologic features and the detected immunoreactivity. Immunohistochemical analyses showed a strong positive reaction for p53 in samples of the SCLC and NSCLC. The cancers had a different phenotype, but similar genetic abnormalities may have developed due to the carcinogens in the cigarettes.
An investigation of recurrent neural network architectures for statistical parametric speech synthesis

In this paper, we investigate two different recurrent neural network (RNN) architectures: Elman RNN and recently proposed clockwork RNN [1] for statistical parametric speech synthesis (SPSS). Of late, deep neural networks are being used for SPSS which involve predicting every frame independent of the previous predictions, and hence requires post-processing for ensuring smooth evolution of speech parameters. RNNs, on the other hand, are intuitively better suited for the task as they inherently model temporal dependencies, but were restricted in use because of the difﬁculty in training. Lately, techniques such as sparse initialization, Nesterov’s accelerated gradient, gradient clipping and leaky integration (LI) have been shown to overcome this difﬁculty. We study the utility of these techniques for SPSS task. In addition, we show that clockwork RNN is equivalent to an Elman RNN with a particular form of LI. This perspective enables us to understand the reason why a simple Elman RNN with LI units performs well on sequential tasks.
Acute Renal Failure in the Neonatal Period

Acute renal failure (ARF) is a common problem in the neonatal intensive care unit (NICU). In most cases, ARF is associated with a primary condition such as sepsis, metabolic diseases, perinatal asphyxia and/or prematurity. This retrospective study investigated the course of illness, therapeutic interventions, early prognosis and risk factors associated with development of ARF in the neonatal period. A total of 1311 neonates were treated in our NICU during the 42‐month study period, and 45 of these babies had ARF. This condition was defined as serum creatinine level above 1.5 mg/dL despite normal maternal renal function. The data collected for each ARF case were contributing condition, cause and clinical course of ARF, gestational age and birth weight, age at the time of diagnosis, treatment, presence of perinatal risk factors and need for mechanical ventilation. The frequency of ARF in the NICU during the study period was 3.4%. Premature newborns constituted 31.1% of the cases. The mean birth weight in the group was 2863 ± 1082 g, and the mean age at diagnosis was 6.2 ± 7.4 days. The causes of ARF were categorized as prerenal in 29 patients (64.4%), renal in 14 patients (31.1%) and postrenal in 2 patients (4.4%). Forty‐seven percent of the cases were nonoliguric ARF. Asphyxia was the most common condition that contributed to ARF (40.0%), followed by sepsis/metabolic disease (22.2%) and feeding problems (17.8%). Therapeutic interventions were supportive in 77.8% of the cases, and dialysis was required in the other 22.2%. The mortality rate in the 45 ARF cases was 24.4%. Acute renal failure of renal origin, need for dialysis, and need for mechanical ventilation were associated with significantly increased mortality (p < 0.05). There were no statistical correlations between mortality rate and perinatal risk factors, oliguria, prematurity or blood urea nitrogen and creatinine levels. The study showed that, at our institution, ARF in the neonatal period is frequently associated with preventable conditions, specifically asphyxia, sepsis and feeding problems. Supportive therapy is effective in most cases of neonatal ARF. Acute renal failure of renal origin, need for dialysis, and need for mechanical ventilation were identified as indicators of poor prognosis in these infants. Early recognition of risk factors and rapid effective treatment of contributing conditions will reduce mortality in neonatal ARF.
Crystal structure of pyrazoxyfen

The title compound, C20H16Cl2N2O3 (systematic name: 2-{[4-(2,4-dichlorobenzoyl)-1,3-dimethylpyrazol-5-yl}oxy}-1-phenylethan-1-one), is the benzoylpyrazole herbicide pyrazoxyfen. The asymmetric unit comprises two independent molecules, A and B, in which the pyrazole ring makes dihedral angles of 80.29 (10) and 61.70 (10)° and 87.60 (10) and 63.92 (8)°, respectively, with the dichlorophenyl and phenyl rings. In the crystal, C—H⋯O and C—H⋯N hydrogen bonds, and C—H⋯π and π–π [3.646 (2) Å] interactions link adjacent molecules, forming a two-dimensional network parellel to (011). In addition, the networks are linked by weak intermolecular C—Cl⋯π [3.356 (2), 3.950 (2), 3.250 (2) and 3.575 (2) Å] interactions, resulting in a three-dimensional architecture.
Teratocarcinosarcoma of the nasal cavity and ethmoid

Abstract Sinonasal teratocarcinosarcoma is very unusual malignant neoplasm histologically consisting of an epithelial element and one or more mesenchymal components. This is a report of teratocarcinosarcoma, in a 74-year-old male, involving the right nasal cavity and ethmoids with intracranial extension. The tumour was totally resected via the craniofacial approach and the patient was given post-operative chemotherapy. Extensive tumour necrosis, rapid growth and local destruction are the prominent features of this tumour. The clinical presentation, pathological features and clinical course of this rare malignancy are discussed with a review of the literature.
Apolipoproteins A–I, A–II and B, lipoprotein(a) and the risk of ischaemic heart disease: the Caerphilly Study

Apolipoproteins B, A–I and Lp(a) have been proposed as independent predictors of subsequent ischaemic heart disease (IHD) improving on the prediction obtained by routine lipid measurements. In this report we have investigated the relative predictive ability of apolipoproteins and plasma lipids in a prospective study of middle aged men.
Infrared Dim and Small Target Detection Based on Stable Multisubspace Learning in Heterogeneous Scene

Infrared (IR) dim and small target detection in a highly complex background play an important role in many applications, and remain a challenging problem. In this paper, a novel method named stable multisubspace learning is presented to deal with this problem. The new method takes into account the inner structure of actual images so that it overcomes the shortage of the traditional method. First, by analyzing the multisubspace structure of heterogeneous background data, a corresponding image model is proposed using subspace learning strategy. This model is also stable to noise interference. Second, an efficient optimization algorithm is designed to solve the proposed IR image model. By adding the proper postprocessing procedure, we can get the detection result. Experiments on simulation scenes and real scenes show that the proposed method has superior detection ability under heterogeneous background.
Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells*

O-GlcNAcylation is a dynamic post-translational modification consisting of the addition of a single N-acetylglucosamine sugar to serine and threonine residues in proteins by the enzyme O-linked β-N-acetylglucosamine transferase (OGT), whereas the enzyme O-GlcNAcase (OGA) removes the modification. In cancer, tumor samples present with altered O-GlcNAcylation; however, changes in O-GlcNAcylation are not consistent between tumor types. Interestingly, the tumor suppressor p53 is modified by O-GlcNAc, and most solid tumors contain mutations in p53 leading to the loss of p53 function. Because ovarian cancer has a high frequency of p53 mutation rates, we decided to investigate the relationship between O-GlcNAcylation and p53 function in ovarian cancer. We measured a significant decrease in O-GlcNAcylation of tumor tissue in an ovarian tumor microarray. Furthermore, O-GlcNAcylation was increased, and OGA protein and mRNA levels were decreased in ovarian tumor cell lines not expressing the protein p53. Treatment with the OGA inhibitor Thiamet-G (TMG), silencing of OGA, or overexpression of OGA and OGT led to p53 stabilization, increased nuclear localization, and increased protein and mRNA levels of p53 target genes. These data suggest that changes in O-GlcNAc homeostasis activate the p53 pathway. Combination treatment of the chemotherapeutic cisplatin with TMG decreased tumor cell growth and enhanced cell cycle arrest without impairing cytotoxicity. The effects of TMG on tumor cell growth were partially dependent on wild type p53 activation. In conclusion, changes in O-GlcNAc homeostasis activate the wild type p53 pathway in ovarian cancer cells, and OGA inhibition has the potential as an adjuvant treatment for ovarian carcinoma.
Genetic imbalances in 67 synovial sarcomas evaluated by comparative genomic hybridization

We used comparative genomic hybridization (CGH) to evaluate DNA sequence copy number changes in 67 synovial sarcomas of both monophasic and biphasic histological subtypes. Changes (mean among aberrant cases: 4.7 aberrations/tumor; range: 1–17), affecting most often entire chromosomes or chromosome arms, were detected in 37 sarcomas (55%). Gains and losses were distributed equally, but different chromosomes were affected with variable frequencies. The most frequent aberrations, each detected in 9–11 of 67 tumors, were gain of 8q and gain at 12q (12q14‐15 and 12q23‐qter), loss of 13q21‐31, and loss of 3p. Other frequent changes (in 7 or 8 cases) included gains at 2p, 1q24‐31, and 17q22‐qter, and losses at 3cen‐q23 and 10q21. High‐level amplifications were seen in 7 cases. A total of 16 regions were detected. Two of them, 8p12‐qter and 21q21‐qter, seen in 4 and 2 tumors, respectively, were recurrent. No aberrations specific to histological subtype were identified. However, genetic changes in the monophasic tumors were more complex and numerous (mean among aberrant cases: 5.3 aberrations/tumor; range: 1–17) than in the biphasic tumors (mean: 2.5 aberrations/tumor; range: 1–5), and high‐level amplifications occurred more frequently. All but 1 of the sarcomas showing high‐level amplification were of the monophasic subtype. These findings may reflect differences in the pathogenesis and biological behavior of both histological subtypes of synovial sarcoma. Genes Chromosomes Cancer 23:213–219, 1998. © 1998 Wiley‐Liss, Inc.
Variations in the Hemodialysis Treatment Process

The Medicare end-stage renal disease (ESRD) program costs more than $2 billion a year. Costs per treatment vary significantly across hemodialysis facilities, yet the relationship of these cost differentials to case mix and outcomes is uncertain. This study analyzed treatment variations in 527 chronic hemodialysis patients dialyzing in four freestanding and three hospital-based facilities. Results indicated that patients receiving care in the hospital-based units received a more costly routine dialysis treatment as well as more intensive nursing care during the treatment process than did patients in freestanding units. Policy and clinical implications of the findings are discussed.
Proteomic profiling of N‐linked glycoproteins identifies ConA‐binding procathepsin D as a novel serum biomarker for hepatocellular carcinoma

The aim of this study was to identify novel biomarkers for the diagnosis of, and potential therapeutic targets for, hepatocellular carcinoma (HCC). Multilectin affinity chromatography was used to enrich N‐linked glycoproteins from nontumorous liver and HCC tissues followed by 2DE and protein identification by MS. Twenty‐eight differentially expressed proteins were identified. Western blotting validated consistently lower concentrations of human liver carboxylesterase 1 and haptoglobin, and higher concentration of procathepsin D (pCD) in HCC tissues. Knockdown of cathepsin D (CD) expression mediated by siRNA significantly inhibited the in vitro invasion of two HCC cell lines, SNU449 and SNU473, which normally secrete high‐levels of CD. Prefractionation using individual lectins demonstrated an elevation in ConA‐binding glycoforms of proCD and CD in HCC tissues. In the serum of HCC patients, “ConA‐binding proCD” (ConA‐pCD) is significantly increased in concentration and this increase is comprised of several distinct upregulated acidic isoforms (pI 4.5–5.5). Receiver operating characteristic analysis showed that the sensitivity and specificity of serum ConA‐pCD for HCC diagnosis were 85% and 80%, respectively. This is the first report that serum ConA‐pCD is increased significantly in HCC and is potentially useful as a serological biomarker for diagnosis of HCC.
Oil Price Shock and Structural Changes in CMEA Trade

We analyse trade between countries of the Council of Mutual Economic Assistance in Eastern Europe between 1950 and 1990. Despite central planning and political motivation of the CMEA, we show that trade could be explained by standard demand factors surprisingly well. Moreover, we document that the oil price crisis had several repercussions on Eastern Europe. The Soviet Union as a supplier of crude oil benefited from the energy crisis in the 1970s. In particular, it used energy exports as an instrument of foreign policy. In turn, the responses of the individual CMEA countries in Central Europe were largely different.
Free France's Lion: The Life of Philippe Leclerc, de Gaulle's Greatest General

'William Mortimer Moore has written a fine biography of Leclerc, who played almost as important a part as De Gaulle himself in restoring French pride in the Second World War'. - Antony Beevor, author of D-Day: The Battle of Normandy 'Superb. General Leclerc is one of the few authentic French heroes of the Second World War, and in this exhaustively researched and fast-moving account of his extraordinary life, Mortimer Moore does him full justice. ' - Professor Saul David, author of Zulu: the Heroism and Tragedy of the Zulu War of 1879 But for his early death, many Frenchmen believe Leclerc would have been their greatest figure to emerge from World War II. De Gaulle himself admitted to his son-in-law that he gave up smoking when Leclerc died, in case France needed him, because Leclerc was no longer there. From the fall of France until 1943, Leclerc dovetailed his operations with the British effort in North Africa, establishing himself as a dynamic combat leader in the battles against Rommel. But once the conflict shifted to European soil he became even more prominent as the commander of the 2nd French Armored Division. For the next two years he was under the operational control of either Patton's Third Army, Hodges' First Army, at the Westwall, or Patch's Seventh Army in the south. His career not only includes the liberation of Paris, for which he is most famous, but the retaking of Strasbourg and the reduction of the Colmar Pocket. Aside from a fast-paced narrative covering combat at all levels of command, Leclerc's story will make fascinating reading for any serious student of the full scope of World War II.
Group B Streptococcus Sequence Type 283 Disease Linked to Consumption of Raw Fish, Singapore

An outbreak of invasive group B Streptococcus (GBS) disease occurred in Singapore in mid-2015. We conducted a case–control study of 22 adults with invasive GBS infections during June 21–November 21, 2015. Consumption of raw fish was strongly associated with invasive sequence type 283 infections, but not with non–sequence type 283 infections.
Factors Affecting the Intention of Adopting Cloud Computing in Jordanian Hospitals

The purpose of this study is to examine the different factors that are expected to influence the intention of hospitals to adopt cloud computing in Jordan. This study is conducted using quatititative methodology. 223 questionnaires were distributed to the IT departments of different hospitals to evaluate their ability and willingness to adopt cloud computing. The data were tested using multiple regression in order to determine whether Technology, Organizational, and Environmental factors (TOE) played a role in hospitals’ decision to consider cloud computing as a beneficial investment. The findings of this study showed that all the factors had a significant positive impact on the intention of hospitals to adopt cloud computing, with the Technological factor having the most impact on the decision made.
Interventions to reduce the incidence of falls in adult patients in Acute Care Hospitals: A Systematic Review

Review Objective: The objective of this review is to present the best available evidence for the effectiveness of interventions designed to reduce the incidence of falls in adult patients during hospitalisation. Review Question: How effective are interventions that are designed to reduce the incidence of falls in adult patients during hospitalisation when compared with standard practice or no intervention? Inclusion Criteria: Types of Participants: The review will consider all studies that involved adult patients (aged 18 years or over) in acute care hospitals. Types of Intervention(s): The interventions of interest include those designed to assess the risk of falling or those used to minimise the risk of falling in adult hospital patients. These interventions will be compared to either standard practice, which includes any method or technique already in place at the facility, or no intervention Type of Outcome: This review will consider studies where the outcome of interest is the number of patient falls during hospitalisation.
Variation de trois types de marqueurs genetiques dans l'evolution de l'espece oryctolagus cuniculus : aspects moleculaires et relations avec la biologie et la structure des populations

Trois marqueurs genetiques ont ete utilises pour mesurer l'impact de l'organisation sociale et de l'histoire (dispersion naturelle et dirigee par l'homme) du lapin de garenne sur la structure genetique des populations. Les modalites d'evolution de chacun de ces marqueurs ont ete etudiees. Les microsatellites se comportent apparemment comme des marqueurs neutres. La region de controle de l'adn mitochondrial, par contre, presente une variabilite tres fluctuante le long de sa sequence, probablement en liaison avec differents signaux. Le gene codant pour la partie constante de la chaine legere des immunoglobulines, enfin, est clairement soumis a une selection diversificatrice. L'analyse conjointe de ces marqueurs a permis de confirmer l'existence de deux sous-especes. Elle montre d'autre part que ces deux groupes ne sont pas isoles du point de vue reproductif et qu'ils ont ete remis en contact relativement recemment. Ils sont cependant probablement issus tous deux de populations localisees sur la peninsule iberique. Sur le territoire francais, parmi toutes les populations etudiees, une seule s'est apparemment constituee naturellement, les autres etant le resultat de l'activite humaine. Au sein des populations, enfin, il existe des sous-ensembles, les colonies, qui se comportent comme des unites panmictiques. L'absence de consanguinite sur de si petites unites est probablement liee a la migration differentielle suivant les sexes dont les traces sont visibles d'un point vue genetique
In vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase/invertase family.

The genome of the broad host range Streptomyces temperate phage, phiC31, is known to integrate into the host chromosome via an enzyme that is a member of the resolvase/invertase family of site-specific recombinases. The recombination properties of this novel integrase on the phage and Streptomyces ambofaciens attachment sites, attP and attB, respectively, were investigated in the heterologous host, Escherichia coli, and in an in vitro assay by using purified integrase. The products of attP/B recombination, i.e., attL and attR, were identical to those obtained after integration of the prophage in S. ambofaciens. In the in vitro assay only buffer, purified integrase, and DNAs encoding attP and attB were required. Recombination occurred irrespective of whether the substrates were supercoiled or linear. A mutant integrase containing an S12F mutation was completely defective in recombination both in E. coli and in vitro. No recombination was observed between attB/attB, attP/attP, attL/R, or any combination of attB or attP with attL or attR, suggesting that excision of the prophage (attL/R recombination) requires an additional phage- or Streptomyces-encoded factor. Recombination could occur intramolecularly to cause deletion between appropriately orientated attP and attB sites. The results show that directionality in phiC31 integrase is strictly controlled by nonidentical recombination sites with no requirement to form the topologically defined structures that are more typical of the resolvases/invertases.