Miracle-dz/UniFAR-FTUs huggingface dataset:
The Political Socialization of Adolescent Children of Immigrants.

OBJECTIVES This study aims to evaluate the adolescent political socialization processes that predict political participation in young adulthood, and whether these processes are different for children of immigrants compared to white 3rd-plus generation adolescents. We focus on socialization agents based in the family, community and school. METHODS We use a nationally representative longitudinal survey of adolescents to evaluate the predictors of three measures of political participation: Voter registration, voting, and political party identification, and whether the process leading to political participation varies by immigrant status and race/ethnic group. RESULTS We find that the parental education level of adolescents is not as predictive for many minority children of immigrants compared to white children of native-born parents for registration. Additionally, the academic rigor of the courses taken in high school has a greater positive estimated effect on the likelihood of registration and party identification for Latino children of immigrants compared to white 3rd-plus generation young adults. CONCLUSIONS The process of general integration into U.S. society for adolescent children of immigrants may lead to differing pathways to political participation in young adulthood, with certain aspects of their schooling experience having particular importance in developing political participation behaviors.
Histopathologic Aspects of Photodynamic Therapy for Dysplasia and Early Adenocarcinoma Arising in Barrett’s Esophagus

The efficacy of photodynamic therapy (PDT) is currently evaluated for the treatment of superficial neoplasms arising in Barrett’s esophagus (BE). An accurate assessment of this technique requires the evaluation of biopsies before and after treatment. However, despite the importance of pathology, only a limited number of studies have systematically assessed the mucosal changes after PDT. To evaluate mucosal changes after PDT, and pathologic variables that may impact on the success of this therapy, we analyzed the pre- and post-PDT biopsies of a cohort of patients treated by this modality. Thirty-three patients (mean age, 71 years) with high-grade dysplasia (HGD) and/or intramucosal carcinoma (IMC) arising in BE and followed up after PDT using Porfimer sodium form the basis of this study. In all patients, a review of all pre- and post-PDT biopsies was performed. The variables recorded included the histologic grade and architecture of neoplasms, the distribution of neoplasms, and squamous re-epithelialization. IMC and HGD coexisted in the pre-PDT biopsies of 18 patients (54.5%). IMC and HGD showed a prominent tubular proliferation in 14 patients and displayed a papillary pattern (at least partially) in 19 patients. In post-PDT, patches of specialized columnar epithelium were buried under squamous epithelium in 17 patients (51.5%), and foci of dysplasia/carcinoma covered by squamous epithelium were found in 9 patients (27.3%). HGD and/or IMC were eradicated in 17 patients (eradicated group) and persisted in 16 patients (persistent group). In the persistent group, grade and architecture were unchanged after PDT in 62.5% and 87.5% of patients, respectively. The persistent group was characterized by: 1) a more frequent papillary architecture (P < 0.05), and 2) a diffuse distribution of the neoplasms on pre-PDT biopsies (P = 0.05). Singularly, the persistent neoplastic lesions were observed in the distal esophagus (P < 0.05). A systematic histopathologic evaluation allowed us to draw attention to the fact that distally located and papillary-type neoplasia seem resistant to PDT. The higher than expected incidence of buried residual neoplastic epithelium should also be emphasized since it represents a risk for undetected growth of malignancy.
Mastectomy patients and the fear of cancer recurrence

Summary ABSTRACT The purpose of this study was to determine the relationship between significant others and fear of disease recurrence in patients in cancer remission. A sample, consisting of 30 mastectomy patients in cancer remission, was administered a Fear of Recurrence Questionnaire and a Significant Other Interview instrument. Data analyses indicated a strong negative relationship between significant others and fear of recurrence. Those subjects reporting fewer significant others had higher fear of recurrence scores, whereas those subjects reporting more significant others had lower fear of recurrence scores. A strong negative relationship was also found between the number of significant others whom the subject identified as understanding her health concerns and fear of recurrence. Analysis of the demographic data showed that age, marital status, extent of disease, type of adjuvant treatment, time since surgery, and time since last treatment were not significantly related to fear of recurrence. Discussion centered on the crucial relationship between subjects' number of significant others and their threat of disease recurrence. Also discussed was the importance of mobilizing support systems as a means of lessening the threat of disease recurrence and maximizing subjects' potential for quality of life.
Heart rate and the cardiovascular risk

In recent years evidence has been accumulating that the heart rate is a major correlate of blood pressure, that it may predict the development of sustained hypertension in subjects with normal or borderline elevated blood pressure values, and that it is associated with increased risks of cardiovascular and noncardiovascular death. In spite of the evidence physicians tend to overlook these facts, and the heart rate is either ignored or viewed as a particularly benign prognostic sign. The educators in our field also tend to underestimate the value of the topic; most textbooks contain little reference to research results on relationships among the heart rate, hypertension and cardiovascular prognosis.
Energy Evaluation of Spatial Modulation at a Multi-Antenna Base Station

In this paper, we aim to study the Energy Efficiency (EE) of Spatial Modulation (SM) at different Base Stations (BSs) taking into account the total power consumption. Compared to conventional Multiple-Input Multiple-Output (MIMO) schemes, SM benefits from a single Radio Frequency (RF) chain which results in decreased power supply (W), higher EE (Mbits/J), and reduced complexity. Using the fundamental limits of Shannon capacity, we show that SM achieves a range of average data rates with only a fraction, which can be as low as 24% for four transmit antennas, of the total power supply of conventional MIMO. In addition, we demonstrate that the EE of the studied schemes is maximized for a certain average data rate and that SM achieves the highest EE among them. Finally, we note that a BS employing SM can be up to 67% more energy efficient compared to a BS under a conventional MIMO transmission scheme, for four transmit antennas.
Relationship between ocular surface temperature and peripheral vasoconstriction in healthy subjects: A thermographic study

An impairment of ocular blood flow regulation is commonly considered one of the main pathogenetic mechanisms involved in the development of several eye diseases, like glaucoma. The aim of this study was to investigate whether an alteration of ocular blood supply induced by peripheral vasoconstriction might be detected by measuring the ocular surface temperature. The ocular surface temperature was evaluated in a group of 38 healthy young subjects (28 males and 10 females; mean age: 25.4 ± 4.1 years) by infrared thermography. For each subject, the experimental procedure consisted of two thermographic acquisitions both lasting 10 s, recorded before and during the immersion of both hands in a mixture of ice and water (1.6 °C ± 0.4 °C). Specifically, the second acquisition began 20 s after the hand immersion. Analysis of variance was used to compare the ocular surface temperature of the two profiles. The analysis of infrared images was carried out every 2 s: at the eye opening (t0) until 10 s (t5), for both profiles. Data showed that ocular surface temperature increased significantly (p-value < 0.05), especially near the sources of ocular blood supply, that is, temporal and nasal areas (mean increasing temperature at t0 for P1 = 0.12 °C ± 0.13 °C). Therefore, these results suggest a response of the ocular hemodynamic to the peripheral vasoconstriction. The ocular surface temperature may represent a cheap, non-invasive and non-time-consuming test to evaluate ocular vaso-regulation.
GSK3β: role in therapeutic landscape and development of modulators

Glycogen synthase kinase‐3 beta (GSK3β) is a multifunctional serine/threonine kinase which was originally identified as a regulator of glycogen metabolism. It plays a key role in the regulation of numerous signalling pathways including cellular process such as cell cycle, inflammation and cell proliferation. Over the last few years there is a considerable rise in the number of journals and patents publication by different workers worldwide. Many pharmaceutical companies are focusing on GSK3β as a therapeutic target for the treatment of disease conditions. The present review is focused on signalling pathways of different disease conditions where GSK3β is implicated. In this review, we present a comprehensive map of GSK3β signalling pathways in disease physiologies. Structural analysis of GSK3β along with molecular modelling reports from numerous workers are reviewed in context of design and development of GSK3β inhibitors. Patent landscape of the small molecule modulators is profiled. The chemo space for small molecule modulators extracted from public and proprietary Kinase Chembiobase for GSK3β are discussed. Compounds in different clinical phases of discovery are analysed. The review ends with the overall status of this important therapeutic target and challenges in development of its modulators.
Some surprising phenomena in weak-bond fracture of a triangular lattice

A semi-in3nite crack growing along a straight line in an unbounded triangular-cell lattice and in lattice strips is under examination. Elastic and standard-material viscoelastic lattices are considered. Using the superposition similar to that used for a square-cell lattice (J. Mech. Phys. Solids 48 (2000) 927) an irregular stress distribution is revealed on the crack line in mode II: the strain of the crack-front bond is lower than that of the next bond. A further notable fact about mode II concerns the bonds on the crack line in the lattice strip deformed by a ‘rigid machine’. If the alternate bonds, such that are inclined di=erently than the crack-front bond, are removed, the stresses in the crack-front bond and in the other intact bonds decrease. These facts result in irregular quasi-static and dynamic crack growth. In particular, in a wide range of conditions for mode II, consecutive bond breaking becomes impossible. The most surprising phenomenon is the formation of a binary crack consisting of two branches propagating on the same line. It appears that the consecutive breaking of the right-slope bonds—as one branch of the crack—can proceed at a speed di=erent from that for the left-slope bonds—as another branch. One of these branches can move faster than the other, but with time they can change places. Some irregularities are observed in mode I as well. Under the inAuence of viscosity, crack growth can be stabilized and crack speed can be low when viscosity is high; however, in mode II irregularities in the crack growth remain. It is found that crack speed is a discontinuous function of the creep and relaxation times. 2002 Elsevier Science Ltd. All rights reserved.
N′-(2,4-Dichlorobenzylidene)-2-methylbenzohydrazide

In the title hydrazone compound, C15H12Cl2N2O, the dihedral angle between the two benzene rings is 12.2 (2)°. In the crystal, molecules are linked through intermolecular N—H⋯O hydrogen bonds, forming forming C(4) chains propagating in [001].
Modelling the Small Throw Fault Effect on the Stability of a Mining Roadway and Its Verification by In Situ Investigation

The small throw fault zones cause serious problems for mining engineers. The knowledge about the range of fractured zone around the roadway and about roadway’s contour deformations helps a lot with the right support design or its reinforcement. The paper presents the results of numerical analysis of the effect of a small throw fault zone on the convergence of the mining roadway and the extent of the fracturing induced around the roadway. The computations were performed on a dozen physical models featuring various parameters of rock mass and support for the purpose to select the settings that reflects most suitably the behavior of tectonically disturbed and undisturbed rocks around the roadway. Finally, the results of the calculations were verified by comparing them with in situ convergence measurements carried out in the maingate D-2 in the “Borynia-Zofiowka-Jastrzebie” coal mine. Based on the results of measurements it may be concluded that the rock mass displacements around a roadway section within a fault zone during a year were four times in average greater than in the section tectonically unaffected. The results of numerical calculations show that extent of the yielding zone in the roof reaches two times the throw of the fault, in the floor 3 times the throw, and horizontally approx. 1.5 to 1.8 times the width of modelled fault zone. Only a few elasto-plastic models or models with joints between the rock beds can be recommended for predicting the performance of a roadway which is within a fault zone. It is possible, using these models, to design the roadway support of sufficient load bearing capacity at the tectonically disturbed section.
Jantunen Fixed and Free : Order of the Verbal Predicate and Its Core Arguments in Declarative Transitive Clauses in Finnish Sign Language

The study presented in this article deals with the order of the verbal predicate (V) and its nominal core arguments (Aand P-argument) in declarative transitive clauses in Finnish Sign Language (FinSL). A central finding of the study was that at the macro level of FinSL transitive clauses are not ordered in one unambiguous way, but at least three structural combinations of the verbal and its core arguments are possible: AVP, APV, and PAV. The type of clause was found to affect sign order in that isolated clauses only occurred with the orders AVP and APV, whereas textual clauses also manifested the order PAV, or even involved omission of the core arguments. At the micro level, however, sign order in FinSL showed regular patterns similar to those found in other sign languages: (i) A-argument was always expressed before V, and there was also a strong tendency to express A-argument before P-argument; (ii) verbal initial structures were not used; and (iii) verbals including a classifier morpheme – i.e. verbals on the basis of which FinSL could be identified as a head-marking language – were placed at the end of the sentence. The article also discusses the extent to which the clause is an appropriate unit to be used in the future description of FinSL.
mRNA sequence of three respiratory syncytial virus genes encoding two nonstructural proteins and a 22K structural protein

An mRNA sequence of two human respiratory syncytial viral nonstructural protein genes and of a gene for a 22,000-molecular-weight (22K) protein was obtained by cDNA cloning and DNA sequencing. Sequences corresponding to the 5' ends of the respective transcripts were deduced directly by primer extension and dideoxy nucleotide sequencing of the mRNAs. The availability of a bicistronic clone (pRSC6) confirmed the gene order for this portion of the genome. Contrary to other unsegmented negative-stranded RNA viruses, a 19-nucleotide intercistronic sequence was present between the NS1 and NS2 genes. The translation of cloned viral sequences in the bicistronic and monocistronic clones (pRSNS1 and pRSNS2) revealed two moderately hydrophobic proteins of 15,568 and 14,703 daltons. Their similarity in molecular size explained our earlier inability to resolve these proteins. A DNA sequence of an additional recombinant plasmid (pRSA2) revealed a long open reading frame encoding a 22,156-dalton protein containing 194 amino acids. It was relatively basic and moderately hydrophobic. A protein of this size was readily translated in vitro from a viral mRNA hybrid selected by this plasmid and corresponded to an unglycosylated 22K protein seen in purified extracellular virus but not associated with detergent- and salt-resistant cores. A second open reading frame of 90 amino acids partially overlapping with the C terminus of the 22K protein was also present within this sequence. This was reminiscent of the viral matrix protein gene which was previously shown by us to contain two overlapping reading frames. The finding of three additional viral transcripts encoding at least three identifiable proteins in human respiratory syncytial virus was a novel departure from the usual genetic organization of paramyxoviruses. The 5' ends of all three transcripts had a 5'NGGGCAAAU sequence that is common to all viral transcripts analyzed so far. Although there was no obvious homology immediately upstream of the polyadenylate tail, an AGUUA (AGUAA in the case of NS2) was present between 1 and 4 nucleotides upstream of the polyadenylate end of NS1 and 22K protein mRNAs.
Renal Biopsy in 2015 - From Epidemiology to Evidence-Based Indications

Background: Although the number of patients reaching end-stage kidney disease without a biopsy-proven diagnosis is increasing, the utility of renal biopsy is still an object of debate. We analyzed epidemiological data and the main indications for renal biopsy with a systematic, evidence-based review at current literature. Summary: There is a high discrepancy observed in biopsy rates and in the epidemiology of glomerular diseases worldwide, related to the different time frame of the analyzed reports, lack of data collection, the different reference source population and the heterogeneity of indications. The evidence-based analysis of indications showed that renal biopsy should be crucial in adults with nephrotic syndrome or urinary abnormalities as coexistent hematuria and proteinuria and in corticosteroid resistant-children with severe proteinuria. The knowledge of renal histology can change the clinical management in patients with acute kidney injury significantly, after the exclusion of pre-renal or obstructive causes of kidney damage. Scarce evidence indicates that renal biopsy can be useful in patients with advanced chronic kidney disease and its use should always be considered after weighing the benefits and potential risks. Renal biopsy should be crucial in patients with renal involvement due to systemic disease. In patients with diabetes with atypical features, renal biopsy may be fundamental to diagnose an unexpected parenchymal disease mislabeled as diabetic nephropathy. Finally, in elderly patients, the indications and the risks are not different from those in the general population. Key Message: Renal biopsy still remains a concrete approach for managing a substantial percentage of renal diseases.
Somatostatin receptor scintigraphy in liver metastasis detection from gastroenteropancreatic neuroendocrine tumors.

UNLABELLED In patients with gastroenteropancreatic (GEP) neuroendocrine tumors, we investigated the usefulness of somatostatin receptor scintigraphy (SRS) in the detection of liver metastasis, which represents the most important prognostic factor in these tumors, and in the management of affected patients. METHODS We enrolled 149 patients with GEP tumors, 69 during initial staging and 80 in follow-up. All patients underwent whole-body scanning at 4 and 24 h, followed by abdominal planar and SPECT imaging after intravenous injection of 250 MBq (111)In-pentetreotide. The patients had previously been submitted to 2 of 3 conventional imaging procedures (CIP), such as CT, MRI, and ultrasound of the abdomen within 1 mo before SRS; on the basis of liver CIP data, the patients had been classified into 3 groups as follows: no evidence of liver metastases, the presence of resectable metastases, or the presence of nonresectable metastases. RESULTS Liver metastases were histologically proven in 65 cases. SPECT identified malignant lesions in 60 of 65 patients with metastases (sensitivity, 92.3%), planar imaging identified malignant lesions in 38 of 65 patients (sensitivity, 58.5%), and CIP identified malignant lesions in 52 of 65 patients (sensitivity, 80%). Only SPECT demonstrated liver involvement in 13 patients, whereas CIP showed liver involvement in 5 other cases. Moreover, SPECT was significantly more sensitive than planar imaging and CIP in identifying patients with single lesions. Neither SPECT nor planar imaging showed false-positive results in patients with no evidence of liver metastases, including 21 patients with hemangiomas (specificity, 100%), 12 of which were false-positive on CIP (specificity, 85.7%). SPECT per-lesion sensitivity (92.4%) was significantly higher than that of planar imaging (52.4%) and CIP (79.4%). Moreover, SPECT correctly changed patient classification and, thus, management in 28 of 149 patients (18.8%), whereas planar imaging changed classification in 13 patients (8.7%), identifying new or additional metastases not evident on CIP or excluding metastases on CIP of patients with false-positive findings, thus avoiding unnecessary surgery; however, SPECT classification was incorrect in 3.3% of patients, and planar imaging was incorrect in 17.4%. CONCLUSION (111)In-Pentetreotide SRS is a useful diagnostic tool in the detection of liver metastases in GEP tumor patients. In particular, SPECT proved to be significantly more sensitive and accurate than both planar imaging and CIP. Moreover, SPECT was also the most reliable procedure to obtain correct patient classification, thus guiding the most appropriate therapeutic strategy.
A longitudinal mediation analysis of the effect of negative-self-schemas on positive symptoms via negative affect

Abstract Background Cognitive models postulate that negative-self-schemas (NSS) cause and maintain positive symptoms and that negative affect mediates this link. However, only few studies have tested the temporal mediation claim systematically using an appropriate design. Methods A longitudinal cohort design in an online community sample (N = 962) from Germany, Indonesia, and the USA was used. NSS, negative affect and positive symptoms were measured at four time-points (T0–T3) over a 1-year period. Cross-lagged panel and longitudinal mediation analyses with structural equation modeling were used to test the temporal mediation. Results Independent cross-lagged panel models showed a significant unidirectional longitudinal path from NSS to positive symptoms (T2–T3, β = 0.18, p < 0.01) and bidirectional longitudinal associations from NSS to negative affect (T0–T1, γ = 0.14, p < 0.01) and vice versa (T0–T1, γ = 0.19, p < 0.01). There was also a significant indirect pathway from NSS at baseline via negative affect at T1 and T2 to positive symptoms at T3 (unstandardized indirect effect coefficient = 0.020, p < 0.05, BCa CI 0.004–0.035), indicating mediation. Conclusions Our findings support the postulated affective pathway from NSS to positive symptoms via negative affect. Specifically, our data indicate that NSS and negative affect influence each other and build up over the course of several months before leading on to positive symptoms. We conclude that interrupting this process by targeting NSS and negative affect early in the process could be a promising strategy to prevent the exacerbation of positive symptoms.