Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Affecting the Surgical Outcome of Primary Exotropia

Aims To identify the predictors for motor outcome and response to surgical treatment of primary exotropia. Setting Taunton and Somerset Hospital, Somerset, United Kingdom. Study type Retrospective analysis of the surgical treatment of primary exotropia performed in our department over a period of 12 years from April 1991 to May 2003. Methods Case-notes of the patients who had surgical treatment for primary exotropia for the specified period were identified by a hospital computer database (MDI coding). All case-notes were reviewed and the following data were recorded and used for statistical analysis: age at the time of surgery, type and severity of exotropia, presence of amblyopia, AV pattern and vertical deviation, the level of stereopsis, type of surgery, and motor and cosmetic results. The surgical outcome was determined as good motor outcome if tropia was within 10 PD of orthotropia. The response to surgery was derived from the difference between the preoperative and postoperative angle of deviation for distance per amount of muscle surgery in millimetres. Results A total of 124 cases were included in the study. Good motor outcome was achieved in 83 (67%) cases. There was a positive correlation between the preoperative angle of deviation at distance and dose response to surgery (r = 0.6 and p < 0.001) and a negative correlation between average corrected visual acuity and response (r = −0.21 and p = 0.025). There was a statistically significant negative relationship between preoperative stereopsis and response to surgery (p = 0.02). Conclusions Surgical treatment for exotropia is effective and the dose response is correlated to the preoperative angle of deviation and average visual acuity. Poor or no preoperative stereopsis was associated with better response to surgery.
Importance of adult literacy in understanding health disparities

AbstractBACKGROUND: In several recent studies, the importance of education and race in explaining health-related disparities has diminished when literacy was considered. This relationship has not been tested in a nationally representative sample of U.S. adults. OBJECTIVE: To understand the effect of adult literacy on the explanatory power of education and race in predicting health status among U.S. adults. DESIGN: Using the 1992 National Adult Literacy Survey, logistic regression models predicting health status were estimated with and without literacy to test the effect of literacy inclusion on race and education. SUBJECTS: A nationally representative sample of 23,889 noninstitutionalized U.S. adults. MEASURES: Poor health status was measured by having a work-impairing condition or a long-term illness. Literacy was measured by an extensive functional skills test. RESULTS: When literacy was not considered, African Americans were 1.54 (95% confidence interval, 1.29 to 1.84) times more likely to have a work-impairing condition than whites, and completion of an additional level of education made one 0.75 (0.69 to 0.82) times as likely to have a work-impairing condition. When literacy was considered, the effect estimates of both African-American race and education diminished 32% to the point that they were no longer significantly associated with having a work-impairing condition. Similar results were seen with long-term illness. CONCLUSIONS: The inclusion of adult literacy reduces the explanatory power of crucial variables in health disparities research. Literacy inequity may be an important factor in health disparities, and a powerful avenue for alleviation efforts, which has been mistakenly attributed to other factors.
Electromagnetic and mechanical characterisation of ITER CS-MC conductors affected by transverse cyclic loading. III. Mechanical properties

The magnetic field and current of a coil wound with a cable-in-conduit conductor causes a transverse force pushing the cable to one side of the conduit. This load causes elastic and plastic deformation with friction as well as heating due to friction. A special cryogenic press has been built to study the mechanical and electrical properties of full-size ITER conductors under transverse mechanical loading. The cryogenic press can transmit at 4.2 K cyclic forces of 650 kN/m to conductor sections of 400 mm length representative of the peak load on a 50 kA conductor at 13 T. In order to transmit the force directly onto the cable, the conduit is opened partly to allow the cable deformation. The force acting on the cable as well as the displacement are monitored simultaneously in order to determine the mechanical heat generation due to friction. The mechanical loss under load is investigated for the Nb/sub 3/Sn, 45 kA, 10 and 13 T, central solenoid model cell conductors (CSMC). The mechanical heat generation is determined from the hysteresis in the measured curves of displacement versus applied force. The first results of the effect of some 40 loading cycles are presented and the two conductors are compared. A significant decrease of the cable mechanical heat generation after loading cycles is observed.
30 jaar na Wassenaar: de Nederlandse arbeidsverhoudingen in perspectief

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The world's two new middles: Growth, precarity, structural change, and the limitations of the special case

This paper discusses the emergence of two new middles since the Cold War, namely middle-income countries and people living above absolute poverty but below a security-from poverty-line. The paper sets out what has happened. It is argued that although there has been substantial economic growth, only a relatively small group of the new middle-income countries have achieved structural transformation, and a large proportion of the . middle. people sit precariously just above the new global poverty line. The patterns of growth, precarity, and structural change underlying the emergence of the world.s two middles are discussed.
A four-month gatifloxacin-containing regimen for treating tuberculosis.

BACKGROUND Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin-sensitive pulmonary tuberculosis. METHODS We conducted a noninferiority, randomized, open-label, controlled trial involving patients 18 to 65 years of age with smear-positive, rifampin-sensitive, newly diagnosed pulmonary tuberculosis in five sub-Saharan African countries. A standard 6-month regimen that included ethambutol during the 2-month intensive phase was compared with a 4-month regimen in which gatifloxacin (400 mg per day) was substituted for ethambutol during the intensive phase and was continued, along with rifampin and isoniazid, during the continuation phase. The primary efficacy end point was an unfavorable outcome (treatment failure, recurrence, or death or study dropout during treatment) measured 24 months after the end of treatment, with a noninferiority margin of 6 percentage points, adjusted for country. RESULTS A total of 1836 patients were assigned to the 4-month regimen (experimental group) or the standard regimen (control group). Baseline characteristics were well balanced between the groups. At 24 months after the end of treatment, the adjusted difference in the risk of an unfavorable outcome (experimental group [21.0%] minus control group [17.2%]) in the modified intention-to-treat population (1356 patients) was 3.5 percentage points (95% confidence interval, -0.7 to 7.7). There was heterogeneity across countries (P=0.02 for interaction, with differences in the rate of an unfavorable outcome ranging from -5.4 percentage points in Guinea to 12.3 percentage points in Senegal) and in baseline cavitary status (P=0.04 for interaction) and body-mass index (P=0.10 for interaction). The standard regimen, as compared with the 4-month regimen, was associated with a higher dropout rate during treatment (5.0% vs. 2.7%) and more treatment failures (2.4% vs. 1.7%) but fewer recurrences (7.1% vs. 14.6%). There was no evidence of increased risks of prolongation of the QT interval or dysglycemia with the 4-month regimen. CONCLUSIONS Noninferiority of the 4-month regimen to the standard regimen with respect to the primary efficacy end point was not shown. (Funded by the Special Program for Research and Training in Tropical Diseases and others; ClinicalTrials.gov number, NCT00216385.).
Time Course of Changes in Neuromuscular Parameters During Sustained Isometric Muscle Actions

Abstract Smith, CM, Housh, TJ, Herda, TJ, Zuniga, JM, Camic, CL, Bergstrom, HC, Smith, DB, Weir, JP, Hill, EC, Cochrane, KC, Jenkins, NDM, Schmidt, RJ, and Johnson, GO. Time course of changes in neuromuscular parameters during sustained isometric muscle actions. J Strength Cond Res 30(10): 2697–2702, 2016—The objective of the present study was to identify the time course of changes in electromyographic (EMG) and mechanomyographic (MMG) time and frequency domain parameters during a sustained isometric muscle action of the leg extensors at 50% maximal voluntary isometric contraction. The EMG and MMG signals were measured from the vastus lateralis of 11 subjects to identify when motor unit activation strategies changed throughout the sustained isometric muscle action. The EMG amplitude (muscle activation) had a positive linear relationship (p = 0.018, r 2 = 0.77) that began to increase at the initiation of the muscle action and continued until task failure. Electromyographic frequency (motor unit action potential conduction velocity) and MMG frequency (global motor unit firing rate) had negative quadratic relationships (p = 0.002, R 2 = 0.99; p = 0.015, R 2 = 0.94) that began to decrease at 30% of the time to exhaustion. The MMG amplitude (motor unit activation) had a cubic relationship (p = 0.001, R 2 = 0.94) that increased from 10 to 30% of the time to exhaustion, then decreased from 40 to 70% of the time to exhaustion, and then markedly increased from 70% to task failure. The time course of changes in the neuromuscular parameters suggested that motor unit activation strategies changed at approximately 30 and 70% of the time to exhaustion during the sustained isometric muscle action. These findings indicate that the time course of changes in neuromuscular responses provide insight into the strategies used to delay the effects of fatigue and are valuable tools for quantifying changes in the fatiguing process during training programs or supplementation research.
The association between periodontitis and obstructive sleep apnea: a preliminary study.

BACKGROUND AND OBJECTIVE Periodontitis is becoming a highly prevalent disease worldwide. Obstructive sleep apnea (OSA) is a common disorder that is characterized by repeated disruptions in breathing during sleep, and mouth breathing is a common characteristic among patients with OSA. We aimed to assess the hypothesis that OSA is associated with the onset and progression of periodontal disease. MATERIAL AND METHODS This is a cross-sectional study of a total of 687 participants (460 men and 227 women), 47-77 years of age, who were examined between August 2009 and September 2010 as part of the Korean Genome and Epidemiology Study. The participants underwent standard polysomnography, clinical periodontal examination and health-screening examinations. Periodontitis was defined as clinical attachment level (CAL) ≥ 6 mm and probing pocket depth ≥ 4 mm. OSA was determined using the apnea-hypopnea index (AHI), and an AHI score of ≥ 5 was the cut-off used to indicate the presence of OSA. RESULTS The results showed that 17.5% of the participants had periodontitis, 46.6% had OSA and 60.0% who were diagnosed with periodontitis had OSA. In our study, old age, male gender, current smoking status, mouth breathing during sleep and high AHI were identified as risk factors for periodontitis. OSA was positively associated with periodontitis [odds ratio (OR) = 1.84, 95% confidence interval (CI) = 1.18-2.87], probing pocket depth (OR = 2.22, 95% CI = 1.30-3.77) and CAL (OR = 1.86, 95% CI = 1.07-3.21) in a dose-response manner. Additionally, OSA was positively associated with periodontitis (OR = 2.51, 95% CI = 1.37-4.62) in subjects ≥ 55 years of age, but not in subjects < 55 years of age. CONCLUSION There is a significant association between OSA and periodontal disease. Further research is needed to clarify the causal relationship between the two conditions.
Multiphase Magnetic Resonance Angiography of the Abdominal and Pelvic Arteries: Results of a Bicenter Multireader Analysis

Schoenberg SO, Essig M, Hallscheidt P, et al. Multiphase magnetic resonance angiography of the abdominal and pelvic arteries: results of a bicenter multireader analysis. Invest Radiol 2002;37:20–28. rationale and objectivesThe objective is to assess the diagnostic accuracy and interobserver variability of multiphase 3D gadolinium-enhanced magnetic resonance angiography (3D-Gd-MRA) for assessment of abdominal and pelvic vascular disease. methods.In 41 patients from two different institutions multiphase 3D-Gd-MRA of the aorta and pelvis was performed using an identical scanning protocol. In a single breath-hold three to four consecutive phases were acquired. Stenoses in the renal arteries, and aorta and pelvic arteries were independently evaluated by three readers and compared with digital subtraction angiography. Interobserver variability was compared by means of a &kgr; statistic. results.Accuracy for stenosis grading consistently ranged between 80% and 90% for all three readers in all vessel segments studied. Good interobserver agreement was found with &kgr; values exceeding 0.75. Vessel segments with delayed fill-in could be reliably detected on the multiple successive MRA phases. Overall, MRA was rated slightly superior to Digital Subtraction Angiography in terms of interobserver variability, diagnostic confidence and image quality. conclusions.Multiphase MRA is a highly robust technique with reproducible accuracy for different observers and different institutions. It can therefore be recommended for screening of atherosclerotic abdominal and pelvic disease.
Characterization of the Mixed-Phase States Using Self-Similarity Phenomenon for First-Order Magnetocaloric Metamagnets

The understanding of how magnetocaloric metamagnets transition near the metamagnetic transition region is profoundly important to fundamental research and the application of near-room temperature magnetic refrigeration. Metamagnetic transition is characterized by field-induced transitions between the ferromagnetic (FM) and the paramagnetic (PM) state at temperatures above the Curie temperature. The metamagnetic region has been experimentally shown to exhibit coexistence of FM and PM phases attributed to the materials' intrinsically layered crystallographic structures. An analytical characterization approach is proposed to numerically calculate the fractional compositions of the mixed-state phases. The fractional composition state functions for magnetocaloric metamagnets are formulated by utilizing the self-similarity phenomenon within the material's (∂M/∂T)H curves. This self-similarity is demonstrated by the collapse of the (∂M/∂T)H curves at different field values onto a single scaled curve with low index of dispersion. To study the effectiveness of this new analytical approach, the fractional compositions functions for Gd5Si2Ge2 was evaluated. The calculated Gd5Si2Ge2 fractional composition state functions demonstrate considerable characteristic agreements with previous experimental results. Knowledge of the FM and PM cluster compositions near the metamagnetic region impacts the calculation of Maxwell's Relation and provides a new numerical perspective for enhancing the magnetocaloric properties via the methods of nano-engineering or chemical substitution processes.
Fractured identities: injury and the balletic body

Social worlds shape human bodies and so it is inevitable that there are strong relationships between the body, professional dance and identity. In this article we draw on Bourdieu’s notions of habitus, and various forms of capital, as the main theoretical framework for our discussion. Our ethnography of the balletic body elicited dancers and ex-dancers’ perceptions of their bodies and sought to reveal some of the facets of their embodied habitus. The sheer physicality of their working lives - of feeling exhausted, sweaty and out of breath - is something dancers (like all athletes) become ‘addicted to’. Ageing and injury can reveal this compulsion to dance and so dancers invariably find it very difficult to, for example, give up class once they retire from the stage; or miss a performance if they have a ‘slight injury’. In other words, the vocational calling to dance is so overwhelming that their balletic body is their identity. In addition, there is an unremitting loop between individual habitus and institutional habitus (the ballet company), which affects both the meaning and management of injury. All our informants at the Royal Ballet (London: n = 20) had suffered dance injuries. The injured, dancing body is perceived as an inevitable part of a career in ballet. Everyone spoke of the improved athleticism of dancers, and of the expansion in facilities to maintain healthy dancers. However, most dancers can expect several major injuries during their careers. Such epiphanies force dancers to confront their embodiment, and their thoughts invariably turn to their body, career and self. Critical injuries threaten to terminate a dancer’s career and so endanger their embodied sense of self. On a more everyday level, dancing and performing with painful, niggling injuries is the norm.
Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in eastern Slovakia: a population-based study.

BACKGROUND Elevated gamma-glutamyl transpeptidase (GGT) is present approximately in half of all patients with non-alcoholic fatty liver disease (NAFLD). NAFLD is the liver manifestation of metabolic syndrome (MS). This study aimed to explore the relationship between GGT and MS or proinflammatory parameters. METHODS Data from the cross-sectional HepaMeta study conducted in Slovakia in 2011 among Roma living in rural communities were used. Participants (n = 446) were divided into 2 groups; those with elevated GGT and those with normal GGT levels. MS was diagnosed according to the International Diabetes Federation criteria; presence of central obesity and low density lipoproteins (LDL) or high density lipoproteins (HDL), high triglycerides, hypertension, glucose intolerance or type 2 diabetes. Participants were tested for the presence of MS and its components, and biochemical tests for lipid levels (total cholesterol, HDL, LDL, TG) and inflammatory parameters (high sensitivity C-reactive protein--hs-CRP and ferritin) were performed. RESULTS Of 446 Roma participants, only 29 (6.5%) had GGT levels above the normal value. After exclusion of patients with viral hepatitis and alcohol abuse, patients with elevated GGT suffered from MS more often (p < 0.001), and patients with more MS components had a higher risk of elevated GGT. We found a significant association between GGT and the individual MS components, except HDL (waist circumference > or = 94 cm in men or 80 cm in women: p < 0.01; BMI > 30: p < 0.001; fasting glucose > or = 5.6 mmol/l: p < 0.001; arterial hypertension: p < 0.05, and TAG > or = 1.7 mmol/l: p < 0.001). Patients with elevated GGT levels had also significantly higher hs-CRP (hs-CRP > 2 mg/l: p < 0.001; hs-CRP > 3 mg/l: p < 0.001) and ferritin (ferritin > 300 mg/l: p < 0.01) levels. CONCLUSION Patients with MS have more significantly elevated levels of GGT. There is a significant association of GGT with individual MS components, except HDL and inflammatory parameters (hs-CRP, ferritin).
The 5'-flanking regions of CYP19A1 and CYP19A2 in zebrafish.

This report describes the structure of the 5'-flanking regions of both the CYP19A1 and A2 genes that were isolated from the genome of the zebrafish (Danio rerio). Consensus sequences of three cAMP-responsive elements (CRE), an aryl hydrocarbon-responsive element (AhR/Arnt), a steroidogenic factor 1 (SF-1) site, and a TATA box were observed in the 5'-flanking region of CYP19A1. In contrast, the 5'-flanking region of CYP19A2 was located upstream of an untranslated exon and possessed consensus sequences of a single CRE, an estrogen-responsive element (ERE), a peroxisome proliferator-activated receptor alpha/retinoid X receptor alpha heterodimer-responsive element (PPARalpha/RXRalpha), and a TATA box. Primer extension analysis revealed that the predominant transcription initiation sites for CYP19A1 and A2 transcripts were 28 and 91 bp upstream from the putative translation initiation codon, respectively. These analyses indicate that substantially different regulators, including a variety of environmental xenobiotics, control the expression the two CYP19 genes.
Enforced Bcl‐2 expression in B lymphocytes induces rheumatoid factor and anti‐DNA production, but the Yaa mutation promotes only anti‐DNA production

The presence of rheumatoid factors (RF) is a characteristic feature of patients with rheumatoid arthritis, but not systemic lupus erythematosus. In this study, we have explored the role of theanti‐apoptotic Bcl‐2 protein and the Y‐linked autoimmune acceleration (Yaa) mutation in the production of IgG RF in comparison with IgG anti‐DNA autoimmune responses. Analysis in C57BL/6 mice, in their F1 hybrids with lupus‐prone NZW mice, and in bone marrow chimeras containing mixtures of C57BL/6 bcl‐2‐transgenic and BXSB non‐transgenic cells demonstrated that an enforced Bcl‐2 expression in B cells promoted the induction of IgG anti‐DNA production in these mice, while significant IgG RF responses were observed only in mice developing high levels of gp70‐anti‐gp70 immune complexes and lethal glomerulonephritis. Moreover, in contrast to a synergistic interaction between the Yaa mutation and Bcl‐2 overexpression on IgG anti‐DNA production, the Yaa mutation failed to enhance the production of IgG RF induced in bcl‐2‐transgenic mice. Our results reveal that defects in the regulation of B cell apoptosis play a critical role in the production of IgG RF, and that the Yaa mutation differentially modulates RF and anti‐DNA autoimmune responses, likely related to the nature of autoantigens involved in each autoimmune response.