Miracle-dz/UniFAR-FTUs huggingface dataset:
Implementing yoga therapy adapted for older veterans who are cancer survivors.

OBJECTIVES This goal of this paper is to describe the reach, application, and effectiveness of an 8-week yoga therapy protocol with older cancer survivors within a Veterans Health Administration setting. METHODS To document the reach of this intervention, recruitment efforts, attendance, and practice rates were tracked. To explore the application of the protocol to this population, physical therapy preassessment and observations by the yoga therapist were recorded to ascertain necessary pose modifications. Effectiveness was measured through pre- and post-course structured interviews, tracking self-reported symptoms of combat-related posttraumatic stress disorder, depression, anxiety, fatigue, insomnia, and pain. RESULTS Regarding reach, 15% of eligible veterans (n = 14) enrolled, participated in 3-16 classes (M±SD = 11.64±3.39), and practiced at home for 0-56 days (M±SD = 26.36±17.87). Participants were primarily Caucasian (n = 13), male (n = 13), ranged in age from 55 to 78 years (M±SD = 65.64±5.15), and had multiple medical problems. During application, substantial individualized modifications to the yoga therapy protocol were necessary. Effectiveness of the intervention was mixed. During post-course interviews, participants reported a variety of qualitative benefits. Notably, the majority of participants reported that breathing and relaxation techniques were the most useful to learn. Group comparisons of mean pre- and post-course scores on standardized measures showed no significant differences. CONCLUSIONS A minority of older veterans express an interest in yoga, but those who do have high rates of class attendance and home practice. Careful physical pre-assessment and attentive therapists are required to undertake the adaptations required by participants with multiple comorbidities. The effectiveness of yoga in this setting requires additional study.
Cultural Differences, Assimilation, and Behavior

We examine the impact of a different cultural background on individual behavior, focusing on penalties in football matches of southern European and northern European football players in the English Premier League. Southern European football players collect on average more football penalties than their British colleagues, and northern European football players collect on average less football penalties than their British colleagues. The number of football penalties incurred by southern European players is initially higher but converges toward the local average the longer their experience in the English Premier League.
Pain and Depression in Older Adults With Arthritis

BACKGROUND: The experience of chronic pain negatively impacts the general health of individuals. Evidence shows that depression and chronic pain co-occur, and both experiences tend to worsen as the number of comorbidities increases. PURPOSE: The purpose of this study was to examine the relationships between pain and depression as well as the impact of number of comorbidities in older adults with arthritis. METHOD: A cross-sectional analysis of existing data was conducted with a sample of 1,592 community-dwelling older adults (mean age = 74.3 years, SD = 5.9 years). FINDINGS: The majority of participants reported the presence of bodily pain. Mild depressive symptoms and multimorbidities were found. More severe pain correlated with a higher number of comorbidities and worsening depression. IMPLICATIONS: Prevalence and impact of pain and other co-occurring conditions suggest their importance in planning care for the elderly with arthritis.
Nodular histiocytic/mesothelial hyperplasia on transthoracic biopsy: another source of potential pitfall in a lesion frequently present in spontaneous pneumothorax

MLH1 immunoreactivity in prostatic adenocarcinoma. The increased MLH1 expression in the precursor lesion HGPIN suggests a role of MLH1 in prostatic carcinogenesis. However, its expression may not be related to the aggressiveness of prostatic cancer, because the intensity of immunoreactivity is similar in both intermediate and high-grade prostatic adenocarcinoma. Lastly, we have demonstrated the feasibility of creating new cocktails containing antibodies specific for malignant (MLH1, AMACR) and benign (34bE12, p63) prostatic epithelia.
The Putnam Group of eastern Connecticut

--_-__-_--____--____-_-__. _--___-_-_----__-_____-___-____ Cl Introduction ______________________________________________________ 1 Putnam Group. __. _. _____-_. ___-. __-_-------___-____-__-___-_-___. 1 Tatnic Hill Formation . ____. ___-. _____. ___. __ 2 Quinebaug Formation__________________________________________ 8 References. ---. -. -. __. -_. -_. _ ______________________________ 11
Essential Role of Cofilin-1 in Regulating Thrombin-induced RelA/p65 Nuclear Translocation and Intercellular Adhesion Molecule 1 (ICAM-1) Expression in Endothelial Cells*

Activation of RhoA/Rho-associated kinase (ROCK) pathway and the associated changes in actin cytoskeleton induced by thrombin are crucial for activation of NF-κB and expression of its target gene ICAM-1 in endothelial cells. However, the events acting downstream of RhoA/ROCK to mediate these responses remain unclear. Here, we show a central role of cofilin-1, an actin-binding protein that promotes actin depolymerization, in linking RhoA/ROCK pathway to dynamic alterations in actin cytoskeleton that are necessary for activation of NF-κB and thereby expression of ICAM-1 in these cells. Stimulation of human umbilical vein endothelial cells with thrombin resulted in Ser3 phosphorylation/inactivation of cofilin and formation of actin stress fibers in a ROCK-dependent manner. RNA interference knockdown of cofilin-1 stabilized the actin filaments and inhibited thrombin- and RhoA-induced NF-κB activity. Similarly, constitutively inactive mutant of cofilin-1 (Cof1-S3D), known to stabilize the actin cytoskeleton, inhibited NF-κB activity by thrombin. Overexpression of wild type cofilin-1 or constitutively active cofilin-1 mutant (Cof1-S3A), known to destabilize the actin cytoskeleton, also impaired thrombin-induced NF-κB activity. Additionally, depletion of cofilin-1 was associated with a marked reduction in ICAM-1 expression induced by thrombin. The effect of cofilin-1 depletion on NF-κB activity and ICAM-1 expression occurred downstream of IκBα degradation and was a result of impaired RelA/p65 nuclear translocation and consequently, RelA/p65 binding to DNA. Together, these data show that cofilin-1 occupies a central position in RhoA-actin pathway mediating nuclear translocation of RelA/p65 and expression of ICAM-1 in endothelial cells.
Cytokine Genotyping in Preeclampsia

Problem Considering that cytokines are involved in preeclampsia (PE) pathogenesis and that cytokine gene polymorphism may affect cytokine production, our purpose was to investigate the association of PE with tumor necrosis factor (TNF)‐α (−308), transforming growth factor‐β1 (+10; 25), interleukin (IL)‐10 (−1082), IL‐6 (−174), and interferon‐γ (+874) polymorphisms.
Oral manifestations of HIV infection in patients receiving highly active antiretroviral therapy (HAART) in Bahia, Brazil.

OBJECTIVES We investigated the oral manifestations of HIV-infected patients in Salvador, Brazil, and their relationship to immunologic, sociodemographic, and therapeutic factors. METHODS This was a cross-sectional study that used data from adult patients' medical records in the dentistry service of the AIDS Reference Center in Salvador, Brazil. We reviewed the patients' records to collect information concerning oral health status and data on socioeconomic status, immunologic status, and treatment. RESULTS A total of 993 patients were included in the study, of whom 473 (47.6 percent) were male. Approximately 5.5 percent of the patients presented with any oral lesions. Oral lesions were the most common in the patients with fewer than 350 CD4+ T lymphocytes (8.4 percent) and with viral loads greater than 10,000 copies (8.3 percent). CONCLUSIONS Our study shows that lesions are more common in patients with advanced immune suppression and low level of schooling. Oral candidiasis and angular chelitis were the most common lesions seen.
Posttraumatic adaptation and distress among adult burn survivors.

OBJECTIVE The purpose of this study was to examine the prevalence, natural history, and psychosocial impact of posttraumatic symptoms in adult burn survivors. METHOD Forty-three adult inpatients at a regional burn center were assessed at discharge with standardized instruments to determine the presence of psychiatric disorder, assess personality, and quantify depression. Thirty-one patients were evaluated 4 months after discharge. RESULTS Posttraumatic stress disorder was diagnosed in 7% of patients at discharge and in over 22% of patients at follow-up. Symptoms of avoidance and emotional numbing (DSM-III-R criterion C symptoms) tended to emerge after discharge from the hospital. While posttraumatic symptoms were associated with symptoms of depression, they were not strongly associated with psychosocial adjustment to illness; psychosocial adjustment was more strongly related to aspects of personality, the injury itself, and its treatment. CONCLUSIONS Since adult burn survivors often develop new symptoms of posttraumatic distress after leaving the hospital, longitudinal surveillance is required to detect new cases and provide appropriate treatment. Survivors at risk for poor psychosocial adjustment after discharge may be identifiable during hospitalization, and preventive treatment strategies should be developed and tested for this population.
OF THE HYPOTHALAMIC-PITUITARY-THYROID AXIS

The activity of the thyroid gland is predominantly regulated by the concentration of the pituitary glycoprotein hormone, thyroid-stimulating hormone (TSH). In the absence of pituitary or of thyrotroph function hypothyroidism ensues. Thus, regulation of thyroid function in normal individuals is to a large extent determined by the factors which regulate the synthesis and secretion of TSH. Those factors are reviewed in this chapter and consist principally of thyrotropin-releasing hormone (TRH) and the feedback effects of circulating thyroid hormones at the hypothalamic and pituitary levels. The consequence of the dynamic interplay of these two dominant influences on TSH secretion, the positive effect of TRH on the one hand and the negative effects of thyroid hormones on the other, result in a remarkably stable morning concentration of TSH in the circulation and consequently little alteration in the level of circulating thyroid hormones from day to day and year to year. This regulation is so carefully maintained that an abnormal serum TSH in most patients is believed to indicate the presence of a disorder of thyroid gland function. The utility of TSH measurements has been recognized and its use has remarkably increased, due to the development of immunometric methodologies for its accurate quantitation in serum, although the criteria to define a “normal range” still remain matter of controversy. This chapter is organized into two general sections. The first portion reviews basic studies of TSH synthesis, post-translational modification and release. The second deals with physiological studies in humans which serve as the background to the diagnostic use of TSH measurements and reviews the results of TSH assays in a pathophysiological context. For complete coverage of this and all related areas of Endocrinology, please visit our online web-text, WWW.ENDOTEXT. ORG. THE REGULATION OF THYROID-STIMULATINGHORMONE SYNTHESIS AND SECRETION: MOLECULAR BIOLOGY AND BIOCHEMISTRY
Valuing Information Technology Related Intangible Assets

In this article, we assess the value of information technology related intangible assets and then use data on business practices and management capabilities to understand how this value is distributed across firms. Using a panel of 127 firms over the period 2003–2006, we replicate and extend the finding from Brynjolfsson, Hitt, and Yang (2002) that $1 of computer hardware is correlated with more than $10 of market value. We account for the “missing $9” by broadening the definition of IT to include capitalized software, and then include all purchased and internally developed software, other internal IT services, IT onsulting, and IT-related training (whether or not it is capitalized by the firm). In addition, we use data on IT-related business practices in order to analyze the distribution of IT-related intangibles within the sample. Our results suggest that the “invisible” IT not accounted for on balance sheets is being priced into the market value of firms. We also estimate that there is a 45% to 76% premium in market value for the firms with the highest organizational IT capabilities (based on separate measures of human resource practices, management practices, internal IT use, external IT use, and Internet capabilities), as compared to those with the lowest organizational IT capabilities. Our results thus suggest that contributions of IT to value depend heavily on other factors, and are not a rising tide that lifts all boats.
Innovation Diffusion among Healthcare Workforce: Analysis of Adoption and Use of Medical ICT in Ghanaian Tertiary Hospitals

One of the many notable interventions in the healthcare delivery service in Ghana is the adoption and use of medical technology to different aspects of hospital management especially the integrated Hospital Information Systems. These are comprehensive information support systems (medical sensors, scanners, expert systems, patent record management) implemented in most hospitals to integrate and provide rapid information in respect of patients, clinical, ancillary, legal, financial, service processing and other administrative issues. This research integrates each of the major elements from existing models to predict user acceptance, adoption and use of medical ICT in government hospitals in China and Ghana. Data is collected from a tertiary hospital in Ghana and analysed to evaluate a hierarchy of constraints and stimulants to the adoption and use of Medical ICT in government hospitals in Ghana, determines the extent to which cultural values or others can explain differences in the rate of adoption and use of Medical ICT in government hospitals in developing countries and make policy proposals towards amelioration of the problem of medical ICT adoption and use in government hospitals based on research outcome.
Understanding Non-Adherence From the Inside: Hypertensive Patients’ Motivations for Adhering and Not Adhering

Patients’ low adherence to medical treatment in chronic illnesses is one of the biggest public health problems. Numerous studies attend to the diverse factors associated with patient adherence. However, little research has been done to explore patients’ reasons for non-compliance from their own point of view. In this article, we aim to understand patient non-adherence using dialogical self-theory and qualitative research methods. We interviewed 51 hypertensive patients to explore their anti- and pro-adherence motivations. Results show that most patients adhere and non-adhere to different aspects of treatment programs (medication, exercise, diet) according to the way they construct meaning to those activities. Also, our findings support the notion that patients’ non-adherent behavior aims to preserve important values such as self-esteem, autonomy, affiliation, well-being, freedom, and health (or that more adherence is not worth the extra effort). We discuss the therapeutic relevance of empathically understanding patients’ worldview and implicit beliefs.
[Double crush syndrome in patients with cervical spondylosis or ossification of posterior longitudinal ligament--a clinicophysiological study].

To clarify the clinical characteristics of double crush syndrome (DCS), we evaluated 207 patients with cervical spondylosis (CS) and 19 with ossification of posterior longitudinal ligament of the cervical spine (OPLL) clinicophysiologically. A diagnosis of DCS was based on the following criteria; 1) radiological evidence of CS or OPLL on X-ray films; 2) definite spinal cord compression on cervical magnetic resonance imaging (MRI); 3) neurological deficits in the upper extremities resulting from CS or OPLL; and 4) clinical and/or electrophysiological evidence of entrapment neuropathies in the upper extremities, namely carpal tunnel syndrome (CaTS), Guyon's tunnel syndrome (GTS), and/or cubital tunnel syndrome (CuTS). Pressure-provocative tests were used to confirm clinical entrapment neuropathies. Nerve conduction velocities were also examined. We found 28 patients with DCS (23 CS, 5 OPLL; 12.8% of all patients). There were 9 patients with clinical and electrophysiological DCS, 5 with clinical DCS, and 14 with electrophysiological DCS. Of the total number of patients with DCS, 21 proved to have CaTS, 4 had CuTS, 1 had GTS, 1 had both CaTS and CuTS, and 1 had both CaTS and GTS. Definite spinal cord compression was seen at C5/6 (23 patients), C4/5 (21), C3/4 (13) and C6/7 (10) on cervical MRI. In the majority of patients, neurological deficits of the upper extremities did not result from a single peripheral nerve lesion. It is well known that a discrepancy between neurological manifestation and neuro-imaging sometimes occurs in CS and OPLL, and circulatory disturbance in the spinal cord has been considered a possible pathogenetic mechanism of the disorder. (ABSTRACT TRUNCATED AT 250 WORDS)
Multiscale 3D model of cardiac contraction based on a fiber array

The heart has been modeled as an anatomically arranged and oriented array of contracting fibers. The model was developed to study the interplay between cellular mechanisms and global myocardial function. Our modeling approach combines cellular electrophysiology, force development, and anatomical ventricle model into a multiscale model of cardiac contraction. The model represents myocardial deformation and fluid dynamics. Results show that the multiscale ventricular model is capable of simulating mechanical contraction, pressure generation and load interactions.
Faculty Experiences Developing and Implementing Policies for Exit Exam Testing

Nursing schools use standardized exit examinations to determine student readiness for the NCLEX-RN. Yet little is known about how nursing programs develop policies for using the examinations, set benchmarks scores, and implement remediation strategies with their students. In a phenomenological study, faculty identified a testing policy process that fell into the major themes of triggers for change, policy modification, and reactions to change.
Impaired quality of life in growth hormone–deficient adults is independent of the altered skeletal muscle oxidative metabolism found in conditions with peripheral fatigue

Growth hormone–deficient (GHD) adults often report impaired quality of life (QoL) – with fatigue, a key element. This deficit can improve following GH replacement. The basis of this response is unclear. Perturbations in skeletal muscle metabolism have been demonstrated in several conditions in which fatigue is a prominent symptom. We wished to define the role of skeletal muscle metabolism in the impaired QoL observed in patients with GHD.
Establishing Trauma: The Difficulty Distinguishing between Memories and Fantasies

This paper is intended as a contribution to understanding why, up until recently, there have been so few case reports of actual abuse and its sequelae in the psychoanalytic literature. We suggest that psychoanalytic insights into the nature of psychic reality, while indispensable to the evolution of psychoanalytic thinking, have nonetheless had the adverse effect of collapsing any distinction between unconscious fantasies and repressed memories. Moreover, the idea that knowledge of external reality is itself mentally constructed also has diminished interest in uncovering trauma and “real” history. We present a report of an adult analysis that illustrates the recovery of a dissociated memory of sexual abuse that occurred during adolescence, as a springboard to discuss problems analysts have had in dealing with trauma theoretically. We hypothesize that repressed memories and conscious fantasies can often be distinguished insofar as they may be “stored” or encoded differently, and that consequently the sequelae of trauma and fantasy often, but not always, can be disentangled. We describe some different modes of encoding trauma and some different ways of remembering, reexperiencing, and reenacting it. And, finally, we suggest why traumatic memories are increasingly accessible to patients today.
QTc Prolongation Associated with Combination Therapy of Levofloxacin, Imipramine, and Fluoxetine

OBJECTIVE: To report QTc interval prolongation associated with combination therapy including levofloxacin, imipramine, and fluoxetine. CASE SUMMARY: A 49-year-old white female presented to the emergency department with fever, aches, and pains for the past 3 days. She was diagnosed and treated for pyelonephritis in the hospital. Therapy included intravenous levofloxacin 500 mg every 24 hours and ceftriaxone 2 g every 24 hours, along with her medications upon admission, including imipramine 50 mg at bedtime and fluoxetine 10 mg/day. She was discharged after 5 days and returned the next day with chest tightness and shortness of breath. Upon the second admission, a 12-lead electrocardiogram showed a QTc interval of 509 msec. Levofloxacin was discontinued and the QTc interval fell to 403 msec. The patient was discharged 3 days later and instructed to consult with her primary care physician about discontinuing imipramine. DISCUSSION: This adverse drug reaction is thought to be a pharmacodynamic additive effect among fluoxetine, imipramine, and levofloxacin. Fluoxetine is a potent inhibitor of CYP2D6, and imipramine is metabolized by CYP2D6. Therefore, fluoxetine is able to increase the plasma concentrations of imipramine, leading to QT interval prolongation. Taken with imipramine, levofloxacin can lead to even greater prolongation of the QT interval. Based on the Naranjo probability scale, levofloxacin was possibly associated with cardiac arrhythmias in our patient. CONCLUSIONS: The use of levofloxacin alone, or more often in concomitant therapy with other medications that are known to prolong the QT interval, may cause QT interval prolongation; however, additional studies/case reports are needed to validate this conclusion.
Using personal selling skills to promote pharmacy services.

In recent years, pharmacists have made significant progress in building the supply of pharmaceutical care services. Pharmacists in a variety of practice settings are developing new clinical services and disease management programs to help patients achieve desired health outcomes. These services range from blood lipid management and diabetes education to smoking cessation programs and cancer risk assessment.2–5 As pharmaceutical care pioneer Charles D. Hepler has noted, however, the pharmacy profession has put far less focus on building demand for these same services. Because many patients and physicians may not yet recognize the value of pharmacy-based patient services, the demand for pharmaceutical care remains limited. Although some pharmacies have developed and implemented effective marketing strategies to build demand for new services, many others have experienced difficulty in this regard.6 Creating and maintaining mutually beneficial relationships with patients, physicians, and other stakeholders is essential for successful marketing of pharmacy-based services. This approach, known as relationship marketing, depends on effective use of personal (one-on-one) selling skills.6 By combining personal selling skills with a sound marketing plan, pharmacists can more effectively promote and generate demand for their patient services. This article reviews techniques that help pharmacists become more comfortable and proficient with personal selling activities. These strategies have been used by one of the authors (McDonough) in promoting pharmacy services at Main at Locust Pharmacy in Davenport, Iowa.