Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of foot orthotics on three-dimensional kinematics of the leg and rearfoot during running.

Foot orthotics have been used successfully in the treatment of musculoskeletal symptoms associated with structural variations of the foot. Their effectiveness has been primarily addressed through two-dimensional, frontal plane motion studies of the subtalar joint in individuals considered "clinical pronators. " Recent evidence suggests that assessment of tibial axial rotation in combination with frontal plane analysis of calcaneal inversion/eversion may provide improved understanding of subtalar joint function. The purpose of this study was to examine the effects of semi-rigid foot orthotics on three-dimensional lower limb kinematics in 20 recreational runners presenting with distinct structural foot characteristics. Radiographic measurements were used to classify subjects into a low or high rearfoot profile group. The results of the kinematic analysis showed a significant orthotic effect for rotations occurring from heel contact to peak tibial internal rotation, as well as in the coupling relationship between tibial axial rotation and calcaneal inversion/eversion. Both groups responded similarly with a mean reduction of 2 degrees in tibial internal rotation. No differences were found for the frontal plane rotations for either group when orthotics were worn. The findings suggest that the maximum effect of orthotics may be realized in the first 50% of stance and related to the changes in tibial axial rotation.
Activation of CD4+ and CD8+ T-lymphocytes by insulin and GAD in patients with type 1 or 2 diabetes mellitus

Background The origin of autoimmune disease type 1 diabetes is still unknown. Aim This study assessed the activation of CD4+ and CD8+ T-lymphocytes by human insulin and human glutamate decarboxylase (GAD) in patients with type 1 or type 2 diabetes mellitus (DM) and healthy volunteers. Materials and methods The expression of CD69, a marker of T-lymphocyte activity, was determined in whole blood samples by flow cytometry after 12 h of incubation with or without insulin or GAD. The analysis included samples from 12 type 1 DM patients, 14 type 2 DM patients and 12 healthy volunteers. Results Significant increases in the number of activated CD4+ and CD8+ T-lymphocytes following pre-incubation of whole blood samples with human insulin or GAD were observed in samples from patients with type 1 DM, whereas no activation of these cells was detected in samples from either type 2 DM patients or healthy subjects. Discussion These results indicated that latent pre-activation of CD4+ and CD8+ T-lymphocytes in response to insulin or GAD epitopes occurred in type 1 DM patients. Conclusion These findings suggest that pre-immunization against insulin and/or GAD might be associated with the development of type 1 DM. Alternatively, these results might reflect a non-specific, bystander autoimmune response.
Applications of deep learning in supervised speech separation

Recently, deep learning has been proposed and verified to possess the strong ability to learn and express complex features, which has brought significant research achievements in signal processing. As a challenging task in speech signal processing, monaural speech separation has always been the research focus of researchers. From the usage of traditional signal processing methods and shallow models to the applications of deep learning, a breakthrough has been made in the study of monaural speech separation. This paper firstly makes a brief introduction to various monaural speech separation methods, and then intensively presents the general process of speech separation and the applications of deep learning in speech separation.
Influence of the genetic heterogeneity of the ISDR and PePHD regions of hepatitis C virus on the response to interferon therapy in chronic hepatitis C

Two genomic regions of hepatitis C virus (HCV), the interferon sensitivity‐determining region (ISDR) of the non‐structural 5A gene (NS5A) and the protein kinase‐RNA activated (PKR)‐eukariotic transcription factor (eIF2‐α) phosphorylation homology domain (PePHD) of the structural E2 gene, interact in vitro with the interferon‐inducible cellular PKR protein kinase. Mutations within these regions might, therefore, influence the response to interferon therapy. Viral load at baseline and sequence heterogeneity of HCV in NS5A and E2 regions was studied in 74 HCV‐1b and in 12 HCV‐3a infected patients with chronic hepatitis C who were treated with interferon. As previously reported by us, in a smaller series of patients in which the ISDR region was analyzed [Saiz et al. ( 1998 ) Journal Infectious Diseases 177:839–847], in the present study a low viral load and a high number of amino acid mutations within the ISDR, but not within the PePHD region, were significantly associated with long‐term response to interferon among HCV‐1b infected patients. No relationship between these viral features and response to therapy was disclosed in patients infected with HCV‐3a. J. Med. Virol. 65:35–44, 2001. © 2001 Wiley‐Liss, Inc.
Ensembles of Elastic Distance Measures for Time Series Classification

Recently, several alternative distance measures for comparing time series have been proposed and evaluated on Time Series Classification (TSC) problems. These include variants of Dynamic Time Warping (DTW), such as weighted and derivative DTW, and edit distance-based measures, including Longest Common Subsequence and Time Warp Edit Distance. These measures have the common characteristic that they operate in the time domain and compensate for potential localised misalignment through some elastic adjustment. Our aim is to experimentally test two hypotheses related to these distance measures. Firstly, we test whether there is any significant difference in accuracy for TSC problems between nearest neighbour classifiers using these distance measures. Secondly, we test whether combining these elastic distance measures through simple ensemble schemes gives significantly better accuracy. We test these hypotheses by carrying out one of the largest experimental studies ever conducted into time series classification. Our first key finding is that there is no significant difference between the elastic distance measures in terms of classification accuracy on our data sets. Our second finding, and the major contribution of this work, is to define an ensemble classifier that significantly outperforms the individual classifiers. Nearly all TSC papers in the data mining literature cite DTW (with warping window set through cross validation) as the benchmark for comparison. We believe that our ensemble is the first ever classifier to significantly outperform DTW and as such raises the bar for future work in this area.
Soil fungal communities of grasslands are environmentally structured at a regional scale in the Alps

Studying patterns of species distributions along elevation gradients is frequently used to identify the primary factors that determine the distribution, diversity and assembly of species. However, despite their crucial role in ecosystem functioning, our understanding of the distribution of below‐ground fungi is still limited, calling for more comprehensive studies of fungal biogeography along environmental gradients at various scales (from regional to global). Here, we investigated the richness of taxa of soil fungi and their phylogenetic diversity across a wide range of grassland types along a 2800 m elevation gradient at a large number of sites (213), stratified across a region of the Western Swiss Alps (700 km2). We used 454 pyrosequencing to obtain fungal sequences that were clustered into operational taxonomic units (OTUs). The OTU diversity–area relationship revealed uneven distribution of fungal taxa across the study area (i.e. not all taxa are everywhere) and fine‐scale spatial clustering. Fungal richness and phylogenetic diversity were found to be higher in lower temperatures and higher moisture conditions. Climatic and soil characteristics as well as plant community composition were related to OTU alpha, beta and phylogenetic diversity, with distinct fungal lineages suggesting distinct ecological tolerances. Soil fungi, thus, show lineage‐specific biogeographic patterns, even at a regional scale, and follow environmental determinism, mediated by interactions with plants.
Neuroprotection against vascular dementia after acupuncture combined with donepezil hydrochloride: P300 event related potential

Acupuncture can be used to treat various nervous system diseases. Here, 168 vascular dementia patients were orally administered donepezil hydrochloride alone (5 mg/day, once a day for 56 days), or combined with acupuncture at Shenting (DU24), Tianzhu (BL10), Sishencong (Extra), Yintang (Extra), Renzhong (DU26), Neiguan (PC6), Shenmen (HT7), Fengchi (GB20), Wangu (GB12) and Baihui (DU20) (once a day for 56 days). Compared with donepezil hydrochloride alone, P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture. Mini-Mental State Examination score was also higher. Moreover, these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture. These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia, and exerts neuroprotective effects against vascular dementia.
Validation of the Gen-Probe Aptima Qualitative HIV-1 RNA Assay for Diagnosis of Human Immunodeficiency Virus Infection in Infants

ABSTRACT The qualitative Roche HIV-1 DNA Amplicor assay has been used for the past 20 years to diagnose HIV infection in infants and young children but is being phased out; hence, alternative assays must be found. The Gen-Probe Aptima qualitative HIV-1 RNA assay is currently the only FDA-cleared HIV-1 nucleic acid assay approved for diagnosis, but data on the use of this assay with infant plasma are limited. We assessed Aptima's performance using control material for reproducibility and limit of detection and 394 plasma samples (0.2 to 0.5 ml) from HIV-exposed infected and uninfected infants and children for analytical sensitivity and specificity. Assays to assess within-run repeatability and between-run reproducibility indicated that the controls with 10,000 (5 of 5), 200 (5 of 5), 100 (16 of 16), 50 (12 of 12), and 25 (20 of 20) HIV-1 RNA copies/ml (cp/ml) were always positive, and negatives were always negative (20 of 20). The limit of detection was 14 cp/ml, as determined by probit analysis. The analytic sensitivity of the assay was 99.5% (189/190 samples; 95% confidence interval [CI], 97.1 to 99.9%) and specificity was 99.5% (199/200 samples; 95% CI, 97.2 to 99.9%). These results suggest that the assay is suitable for early infant diagnosis of HIV-1.
Subjective assessment by patients of the efficiency of two denture adhesive pastes.

PURPOSE This study evaluated the subjective responses of 30 denture wearers with regard to the effectiveness of two denture adhesive pastes. MATERIALS AND METHODS Thirty patients responded to questions related to retention, chewing ability, taste, duration of adhesives in the mouth, and removal; comparing the use of two denture adhesives based on polymethylvinylether-maleic anhydride compounds or carboxymethyl cellulose. RESULTS The denture adhesive paste based on polymethylvinylether-maleic anhydride (PVM-MA) compound was rated higher (73% and 87%) than carboxymethyl cellulose (CC) adhesive paste (60% and 37%) on chewing ability and duration in the mouth (p= 0.0001 and p= 0.0001, respectively) by experienced denture wearers in both maxilla and mandible. There were no statistically significant differences between the two denture adhesive pastes on the retention of maxillary dentures, taste, and removal of the adhesive (p= 0.08, p= 0.67, and p= 0.41, respectively). CONCLUSIONS All subjects responded that the retention of their dentures was either a little better or much better when using either of the adhesive pastes.
Is There an Association Between Radiological Severity of Lumbar Spinal Stenosis and Disability, Pain, or Surgical Outcome?: A Multicenter Observational Study

Study Design. Observational multicenter study. Objective. To evaluate if the severity of lumbar spinal stenosis (LSS) on magnetic resonance imaging (MRI) correlates with preoperative disability, pain, or surgical outcomes. Summary of Background Data. Surgeons use the morphological appearance of LSS on MRI for clinical decision making. However, the associations between radiological severity of LSS and disability, pain, or surgical outcomes remain unclear. Methods. Evaluation of severity of LSS on preoperative MRI according to the Schizas morphological classification. Patient and treatment data were retrieved from the Norwegian Registry for Spine Surgery. Preopertaive outcome measures were Oswestry disability index (ODI) and numeric rating scale (NRS) scores for back and leg pain. Postopertive outcome measures were ODI and NRS scores for back and leg pain at 1 year, changes in ODI and NRS scores after treatment, duration of surgery, length of hospital stay, and perioperative complications. Results. Of 202 patients included, 7 were found to have mild stenosis, 38 had moderate stenosis, 108 had severe stenosis, and 49 had extreme stenosis. The radiological severity of LSS was not linked to preoperative ODI (P = 0.089), NRS back pain (P = 0.273), or NRS leg pain (P = 0.282) scores. There were no differences in ODI (P = 0.933), NRS back pain (P = 0.652), or NRS leg pain (P = 0.912) scores after 1 year. The radiological severity of stenosis was not associated with change in ODI (P = 0.494), NRS back pain (P = 0.235), NRS leg pain (P = 0.790), duration of surgery (P = 0.661), length of hospital stay (P = 0.739), or perioperative complication rates (P = 0.467). Conclusion. Among patients who underwent decompressive surgery for LSS, radiological severity of stenosis was not associated with preoperative disability and pain, or clinical outcomes 1 year after surgery. In this patient group, the radiological severity of LSS has no clear clinical correlation and should therefore not be overemphasized in clinical decision making. Level of Evidence: 2
Prediction of Toxigenic Fungal Growth in Buildings by Using a Novel Modelling System

ABSTRACT There is growing concern about the adverse effects of fungal bioaerosols on the occupants of damp dwellings. Based on an extensive analysis of previously published data and on experiments carried out within this study, critical limits for the growth of the indoor fungiEurotium herbariorum, Aspergillus versicolor, and Stachybotrys chartarum were mathematically described in terms of growth limit curves (isopleths) which define the minimum combination of temperature (T) and relative humidity (RH) at which growth will occur. Each growth limit curve was generated from a series of data points on a T-RH plot and mathematically fitted by using a third-order polynomial equation of the form RH =a3T3 +a2T2 +a1T + a0. This fungal growth prediction model was incorporated within the ESP-r (Environmental Systems Performance [rstands for “research”]) computer-based program for transient simulation of the energy and environmental performance of buildings. For any specified location, the ESP-r system is able to predict the time series evolution of local surface temperature and relative humidity, taking explicit account of constructional moisture flow, moisture generation sources, and air movement. This allows the predicted local conditions to be superimposed directly onto fungal growth curves. The concentration of plotted points relative to the curves allows an assessment of the risk of fungal growth. The system’s predictive capability was tested via laboratory experiments and by comparison with monitored data from a fungus-contaminated house.
Occupational profiles of men since 1947

* I would like to thank Stephen Knights and Woei Tan Liew for their assistance in assembling the data for this project, John Freebairn, John Creedy, David Johnson, Pete Summers, Joanne Loundes, Mark Harris, Tom Crossley, Bruce Chapman and Matthew Gray for useful comments. All errors remain my responsibility. This project has been funded by a University of Melbourne, Faculty of Economics and Commerce Research Grant.
Head-shaking nystagmus in lateral medullary infarction

Objective: Horizontal head shaking at 2 to 3 Hz can induce nystagmus in patients with central as well as in patients with peripheral vestibulopathy. However, the characteristics and diagnostic value of this post-head-shaking nystagmus (HSN) have not been studied systematically in central vestibulopathy, and little is known of the mechanisms involved. Methods: We analyzed spontaneous and HSN and the effects of baclofen, a GABAB agonist, in 16 patients with acute lateral medullary infarction. Results: These patients showed several characteristics of HSN unlike those observed in peripheral vestibulopathy. HSN was observed in 14 of 16 patients (87.5%), and in all cases, the horizontal component beats toward the lesion side, i.e., was ipsilesional. Even in the eight patients with contralesional spontaneous horizontal nystagmus, the HSN was opposite to the spontaneous nystagmus. Three patients showed unusually strong HSN with a maximum slow-phase velocity greater than 60 degrees/second. Visual fixation markedly suppressed HSN and baclofen reduced HSN. In most of the patients, MRI showed infarctions in the caudal or middle portion of the medulla and spared the rostral portion. Conclusions: We propose that head-shaking nystagmus in lateral medullary infarction is due to unilaterally impaired nodulouvular inhibition of the velocity storage. This proposal is consistent with the results of neuroanatomic studies that demonstrate that Purkinje cells controlling velocity storage in the nodulus and ventral uvula project to the caudal or middle portion of the vestibular nuclei, whereas those subserving visual-vestibular interactions in the flocculus project to the more rostral portion.
Self-Correcting Unsound Reasoning Agents

This paper introduces a formal framework for relating learning and deduction in reasoning agents. Our goal is to capture imperfect reasoning as well as the progress, through introspection, towards a better reasoning ability. We capture the interleaving between these by a reasoning/deduction connection and we show how this—and related—definition apply to a setting in which agents are modeled by first-order logic theories. In this setting, we give a sufficient condition on the connection ensuring that under fairness assumptions the limit of introspection steps is a sound and complete deduction system. Under the same assumption we prove every falsehood is eventually refuted, hence the self-correction property.
Quantitative and qualitative investigations of surface enlarged titanium and titanium alloy implants.

Screw shaped implants of commercially pure (c.p.) titanium and titanium-6aluminum-4vanadium (Ti6A14V) were blasted with particles of TiO2 of mean sizes of 25 microns (Group I) and 75 microns (Group II) and inserted in rabbit bone for 3 months. The surface roughness of the implants was examined and quantified with an optical scanning 3-dimensional instrument (TopScan 3D system), revealing the two alloy surfaces in each group had similar surface roughness. Biomechanical (removal torque) tests showed the c.p. titanium implants to be significantly more stable in the bone bed than those of Ti6A14V. In Group I, the c.p. titanium implants demonstrated a mean removal torque of 38 N cm while the Ti6A14V demonstrated a mean removal torque of 27 N cm (P = 0.004). Group II implants revealed a mean removal torque of 70 N cm for the c.p. ti and 50 N cm for the alloy samples (P = 0.003). The removal torque values were converted to shear forces/strengths by three calculation methods, based on (a) the entire length of the implant surface in the cortical region, (b) the thickness of the cortical bone measured in close vicinity to the thread peaks and (c) the bone-metal contact length measured on the non-unscrewed neighbouring implants. Group I: (a) the c.p. ti implants revealed a mean shear force of 4 vs a mean of 3 N/mm2 for the alloy samples. Shear strengths based on (b); were 8 for c.p. ti vs 6 N/mm2 for the alloy. The mean shear strength/force if calculated according to (c) revealed 23 for c.p. ti vs 18 N/mm2 for the alloy. Corresponding numbers for Group II; (a) c.p. ti 8 compared to 6 N/mm2 for the alloy, (b) c.p. ti demonstrated a mean value of 17 vs 11 N/mm2 for the alloy. According to method (c); c.p. ti had a mean shear strength of 26 vs 22 N/mm2 for the alloy samples. Histomorphometrical comparisons were performed on 10 microns thick undecalcified ground sections in the light microscope. In both Group I and Group II, the calculations of the mean bone-to-metal contact demonstrated more bone in contact to the c.p. titanium implants than to the Ti6A14V ones. Whereas comparisons of the bone volume inside the threads demonstrated slightly higher bone volumes around the alloy samples, no statistically significant difference was obtained between the two materials histomorphometrically.
Effects of a Positive Allosteric Modulator of Group II Metabotropic Glutamate Receptors, LY487379, on Cognitive Flexibility and Impulsive-Like Responding in Rats

Orthosteric group II metabotropic glutamate receptor (mGluR) agonists are regarded as novel, effective medications for all major symptom domains of schizophrenia, including cognitive disturbances. mGluR2s also can be affected in a more subtle way by positive allosteric modulators (PAMs) characterized by a unique degree of subtype selectivity and neuronal frequency-dependent activity. Because currently available treatments for schizophrenia do not improve cognitive dysfunction, the main aim of the present study was to examine the effects of a mGluR2 PAM, N-(4-(2-methoxyphenoxy)-phenyl-N-(2,2,2-trifluoroethylsulfonyl)-pyrid-3-ylmethylamine (LY487379), on rat cognitive flexibility and impulsive-like responding, assessed in an attentional set-shifting task (ASST) and a differential reinforcement of low-rate 72 s (DRL72) schedule of food reinforcement. In addition, in vivo microdialysis was used to assess the drug's impact on cortical levels of dopamine, norepinephrine, serotonin, and glutamate. Rats treated with LY487379 (30 mg/kg) required significantly fewer trials to criteria during the extradimensional shift phase of the ASST. Under a DRL72 schedule, LY487379 (30 mg/kg) decreased the response rate and increased the number of reinforcers obtained. These effects were accompanied by the shift of the frequency distribution of responses toward longer inter-response time durations. LY487379 significantly enhanced extracellular norepinephrine and serotonin levels in the medial prefrontal cortex. In summary, the present study demonstrates that a mGluR2 PAM, LY487379, promotes cognitive flexibility and facilitates behavioral inhibition. These procognitive effects may contribute to the therapeutic efficacy of agents stimulating mGluR2 in schizophrenia.