Miracle-dz/UniFAR-FTUs huggingface dataset:
Epidemiological, Clinical, Molecular Features and Early Detection Strategy of Most Frequent Hereditary Cancers in Latvia

Epidemiological, Clinical, Molecular Features and Early Detection Strategy of Most Frequent Hereditary Cancers in Latvia The aim of the study was to determine epidemiological, clinical and molecular features of hereditary breast-ovarian, colorectal, endometrial, prostate and pancreatic cancer in Latvia. The study was performed from 2006 to 2009. Family cancer histories and DNA samples from 5,040 cancer cases were collected, and more than 6,000 molecular tests were performed including multiplex PCR, direct sequencing, denaturing high performance liquid chromatography and others. For the first time, a BRCA2 gene mutation positive hereditary breast cancer family was identified. The necessity of 2 BRCA1 gene founder mutations testing, irrespective of family cancer history for breast and ovarian cancer patients, was confirmed on a large number of positive cases. Regarding hereditary ovarian cancer, every ninth case affected with this malignancy was associated with the BRCA1 gene mutation. For the first time, positive familial adenomatous polyposis cases positive for APC gene mutation were reported and data on the clinical frequency of hereditary endometrial and prostate cancer were provided. In pancreatic cancer patients there was a 3.5% frequency of BRCA1 gene founder mutations. Izplatītākā Pārmantotā Vēža Gadījumu Epidemiologisko, Klīnisko un Molekulāro Īpatnību Agrīnas Noteikšanas Stratēgija Darba mērķis bija izpētīt pārmantotā krūts, olnīcu, kolorektālā, endometrija, prostatas un aizkuņga dziedzera vēža epidemiologiskās, klīniskās un molekulārās īpatnības Latvijā. Pētījums tika veikts no 2006. gada līdz 2009. gadam. Kopumā gimenes onkologiskā anamnēze un perifēro asiņu DNS paraugi tika iegūti 5040 vēža gadījumos. Tika veikti vairāk kā 6000 molekulārie testi, lietojot polimerāzes ķēdes reakcijas, sekvenēšanas, denaturējošo augstas veiktspējas šķidrās hromatogrāfijas metodes un citus molekulāros izmeklējumus. Pirmo reizi Latvijā atklāta BRCA2 gēna mutācija, kas pārmantota krūts vēža gadījumā. Ar lielu gadījumu skaitu tika apstiprināts divu Latvijā biežāko BRCA1 gēna mutāciju (4153delA and 5382insC) testa lietderīgums visiem krūts un olnīcu vēža gadījumiem, neatkarīgi no gimenes onkologiskās anamnēzes. Pārmantotā olnīcu vēža pētījumā tika konstatēts, ka katrs devītais olnīcu vēža gadījums Latvijā ir saistīts ar BRCA1 gēna mutāciju. Pirmo reizi arī ziņojam par gimenes adenomatozās polipozes gadījumiem, kas saistīti ar APC gēna mutācijām. Pētījuma gaitā iegūti unikāli epidemiologiski dati par pārmantoto endometrija un prostatas vēzi, kā arī atklāts, ka 3,5% gadījumos aizkuņga dziedzera vēzis saistīts ar patogēnu mutāciju BRCA1 gēnā.
External Iliac Artery Stenting

Objectives: To review immediate results, patency rates, hemodynamic success, and incidence of concomitant procedures with external iliac artery stenting (EIAS). Methods: Demographic features, category and clinical grade, Trans-Atlantic Inter-Society Consensus II classification lesion type, pre- and postprocedure ankle–brachial indices, and primary patency were compared between group 1 (EIAS without distal revascularization) and group 2 (EIAS with concomitant distal revascularization). Results: No mortality and a 100% immediate technical success rate was recorded in group 1 (n = 12) and group 2 (n = 24). Eleven patients (30.6%) also had stenting of the adjacent common iliac artery. Two thirds of group 2 patients required concomitant femoral or distal revascularization. Conclusions: No difference in stent patency rates was found between patients in group 1 versus group 2. Patients requiring EIAS tend to have more diffuse arterial disease necessitating complicated open reconstruction and/or distal revascularization, as well as more proximal iliac stenting.
Nitrogen Fertilizer Rate and Cultivar Interaction Effects on Nitrogen Recovery, Utilization Efficiency, and Agronomic Performance of Spring Barley

A study was carried out at Lacombe, Alberta, to develop baseline information on nitrogen recovery, utilization efficiency, and agronomic performance of spring barley. This information may enable us to understand where the inefficiencies of N nutrition may lay and determine strategies to improve nitrogen use efficiency (NUE). Three divergent cultivars, “Manley” (two-rowed, tall, late maturing), “Noble” (six-rowed, mid-height, intermediate maturing), and “Tukwa” (six-rowed, semidwarf, early maturing), were grown under low (0 kg ha-1), moderate (50 kg ha-1) and high (100 kg ha-1) rates of applied N fertilization. Both N recovery and utilization efficiency decreased with the increase in rate of applied N fertilizer, and NUE declined from 45 kg kg-1N under the low N treatment to 33 kg kg-1N under the moderate treatment and 24 kg kg-1N under the high N treatment. The test cultivars were comparable in N uptake, but Tukwa and Noble were more efficient in their utilization of the N taken up than Manley, particularly under high N. Subsequently, while grain yield of Tukwa and Noble had increased linearly with rate of N fertilizer, the grain yield of Manley showed a declining trend under high N. This implies that, where a high input condition is targeted, improvement in N utilization efficiency may need to be given due consideration.
Deficiencies Persist in the Experience of UK Vascular Trainees

Aims.To evaluate the training experience of the current United Kingdom (UK) vascular trainees. Methods. A Web-based questionnaire was administered to 217 members of the Rouleaux Club, which represents UK vascular and endovascular trainees, between May and June 2011. Results. A total of 153 trainees (71% response rate) completed the survey; 52% were in posts that do not offer endovascular training, 88% performed <10 peripheral angiograms, and 67% performed part or all of <10 endovascular aneurysm repairs in the last year. Half had no access to formal ultrasound training; 85% believe that vascular access will play a role in their future practice, but 49% performed no vascular access procedures in the past year. No experience of endovenous laser, radiofrequency ablation, or foam sclerotherapy was reported by 33%, 49%, and 46%, respectively. Conclusions. Trainee experience is insufficient for a modern specialist practice. Separate specialty training in the United Kingdom must address these deficiencies.
A new simple ∞OH neuron model as a biologically plausible principal component analyzer

A new approach to unsupervised learning in a single-layer neural network is discussed. An algorithm for unsupervised learning based upon the Hebbian learning rule is presented. A simple neuron model is analyzed. A dynamic neural model, which contains both feed-forward and feedback connections between the input and the output, has been adopted. The, proposed learning algorithm could be more correctly named self-supervised rather than unsupervised. The solution proposed here is a modified Hebbian rule, in which the modification of the synaptic strength is proportional not to pre- and postsynaptic activity, but instead to the presynaptic and averaged value of postsynaptic activity. It is shown that the model neuron tends to extract the principal component from a stationary input vector sequence. Usually accepted additional decaying terms for the stabilization of the original Hebbian rule are avoided. Implementation of the basic Hebbian scheme would not lead to unrealistic growth of the synaptic strengths, thanks to the adopted network structure.
Analysis and assessment of the effects of phase noise in constant envelope multicarrier satellite transmissions

Constant-Envelope (CE) multicarrier techniques have been recently proposed in order to enable the use of multicarrier waveforms in channels characterized by severe nonlinear distortions. They are based on a phase modulation applied to the multicarrier signal, generated in the time domain by means of a real-valued DFT. Such techniques, known as CE-OFDM and CE-SC-FDMA, demonstrated their superior performance with respect to conventional OFDMA and SC-FDMA, when applied to nonlinear satellite channels, at the price of reduced spectral efficiency. An open issue still to be evaluated is related to the impact of phase noise on the performance of CE multicarrier systems. This is especially important in view of the use of EHF bands for broadband satellite communications. This paper aims at analyzing the effects of phase noise on CE-OFDM and CE-SC-FDMA, highlighting the different behavior of conventional and CE multicarrier signals in the presence of such impairment. Then, simulation results will be discussed considering two different phase noise masks. The performed analysis demonstrates that CE multicarrier signals have globally better performance when both phase noise and nonlinear distortions are considered. Moreover, the sensitivity to the phase noise is strongly dependent from the modulation order and the angular modulation index.
A General Projection Neural Network for Solving Monotone Variational Inequalities and Related Optimization Problems

Recently, a projection neural network for solving monotone variational inequalities and constrained optimization problems was developed. In this paper, we propose a general projection neural network for solving a wider class of variational inequalities and related optimization problems. In addition to its simple structure and low complexity, the proposed neural network includes existing neural networks for optimization, such as the projection neural network, the primal-dual neural network, and the dual neural network, as special cases. Under various mild conditions, the proposed general projection neural network is shown to be globally convergent, globally asymptotically stable, and globally exponentially stable. Furthermore, several improved stability criteria on two special cases of the general projection neural network are obtained under weaker conditions. Simulation results demonstrate the effectiveness and characteristics of the proposed neural network.
Multilaboratory Approach to Preclinical Evaluation of Vaccine Immunogens for Placental Malaria

ABSTRACT Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes that adhere to the placental receptor chondroitin sulfate A (CSA) and sequester in the placenta; women become resistant to pregnancy malaria as they acquire antiadhesion antibodies that target surface proteins of placental parasites. VAR2CSA, a member of the P. falciparum EMP1 variant surface antigen family, is the leading candidate for a pregnancy malaria vaccine. Because VAR2CSA is a high-molecular-weight protein, a vaccine based on the full-length protein may not be feasible. An alternative approach has been to develop a vaccine targeting individual Duffy binding-like (DBL) domains. In this study, a consortium of laboratories under the Pregnancy Malaria Initiative compared the functional activity of antiadhesion antibodies elicited by different VAR2CSA domains and variants produced in prokaryotic and eukaryotic expression systems. Antisera were initially tested against laboratory lines of maternal parasites, and the most promising reagents were evaluated in the field against fresh placental parasite samples. Recombinant proteins expressed in Escherichia coli elicited antibody levels similar to those expressed in eukaryotic systems, as did the two allelic forms of the DBL4 and DBL5 domains. The procedures developed for this head-to-head comparison will be useful for future evaluation and down-selection of malaria vaccine immunogens.
Replication and Distribution of Toxoplasma gondii in the Small Intestine after Oral Infection with Tissue Cysts

ABSTRACT Natural infection by Toxoplasma gondii occurs via oral ingestion of tissue cysts that rupture in the small intestine, releasing zoites that infect locally before disseminating throughout the host. The studies presented here used fluorescent parasites combined with flow cytometry and multiphoton microscopy techniques to understand the events associated with parasite replication in the mucosa. At 3 days postinfection with tissue cysts, parasites were localized in small foci and flow cytometry revealed parasites present in macrophages, neutrophils, and monocytes in the lamina propria. By day 6 postinfection, there were large foci of replicating parasites; however, foci unexpectedly varied in the number of villi involved and were associated with the presence of viable tachyzoites within the intestinal lumen. Consistent with the flow cytometry data, neutrophils and monocytes in the lamina propria were preferentially associated with parasite plaques. In contrast, dendritic cells comprised a small fraction of the infected immune cell population and were localized at the periphery of parasite plaques. Together, these findings reveal the formation of localized sites of parasite replication and inflammation early during infection and suggest that sustained replication of T. gondii in the gut may be a function of pathogen luminal spread.
Facial expression recognition using kernel canonical correlation analysis (KCCA)

In this correspondence, we address the facial expression recognition problem using kernel canonical correlation analysis (KCCA). Following the method proposed by Lyons et al. and Zhang et al. , we manually locate 34 landmark points from each facial image and then convert these geometric points into a labeled graph (LG) vector using the Gabor wavelet transformation method to represent the facial features. On the other hand, for each training facial image, the semantic ratings describing the basic expressions are combined into a six-dimensional semantic expression vector. Learning the correlation between the LG vector and the semantic expression vector is performed by KCCA. According to this correlation, we estimate the associated semantic expression vector of a given test image and then perform the expression classification according to this estimated semantic expression vector. Moreover, we also propose an improved KCCA algorithm to tackle the singularity problem of the Gram matrix. The experimental results on the Japanese female facial expression database and the Ekman's "Pictures of Facial Affect" database illustrate the effectiveness of the proposed method.
Effective task scheduling in proximate mobile device based communication systems

Despite the increasing capabilities, mobile devices still cannot satisfy the computation requirement of many applications. Intuitively, this can be solved by outsourcing tasks to external resources such as a remote server, cloud, or closely deployed cloudlet. However, all of them require extra infrastructures. In this paper, we consider a proximate-mobile-device based communication system in which all tasks and resources are under the control of a central scheduler. We propose a friendship-based task scheduling algorithm to address the contentions when resources are not sufficient. We also present two attack models including the denial-of-service (DoS) attack and the collusion attack. We evaluate the performance of the proposed algorithm along with another contribution-based task scheduling algorithm through extensive experiments.
The Rickettsia conorii Autotransporter Protein Sca1 Promotes Adherence to Nonphagocytic Mammalian Cells

ABSTRACT The pathogenesis of spotted fever group (SFG) Rickettsia species, including R. conorii and R. rickettsii, is acutely dependent on adherence to and invasion of host cells, including cells of the mammalian endothelial system. Bioinformatic analyses of several rickettsia genomes revealed the presence of a cohort of genes designated sca genes that are predicted to encode proteins with homology to autotransporter proteins of Gram-negative bacteria. Previous work demonstrated that three members of this family, rOmpA (Sca0), Sca2, and rOmpB (Sca5) are involved in the interaction with mammalian cells; however, very little was known about the function of other conserved rickettsial Sca proteins. Here we demonstrate that sca1, a gene present in nearly all SFG rickettsia genomes, is actively transcribed and expressed in R. conorii cells. Alignment of Sca1 sequences from geographically diverse SFG Rickettsia species showed that there are high degrees of sequence identity and conservation of these sequences, suggesting that Sca1 may have a conserved function. Using a heterologous expression system, we demonstrated that production of R. conorii Sca1 in the Escherichia coli outer membrane is sufficient to mediate attachment to but not invasion of a panel of cultured mammalian epithelial and endothelial cells. Furthermore, preincubation of a recombinant Sca1 peptide with host cells blocked R. conorii cell association. Together, these results demonstrate that attachment to mammalian cells can be uncoupled from the entry process and that Sca1 is involved in the adherence of R. conorii to host cells.
STUDIES UPON MINUTE HEMOLYTIC STREPTOCOCCI

1. Minute beta hemolytic streptococci were found to occur from one-third to one-half as frequently in normal individuals as do ordinary beta hemolytic streptococci. 2. They were rarely isolated from the rhinopharynges of individuals suffering from chronic disease. 3. In acute respiratory tract infection other than that due to the ordinary beta hemolytic streptococcus the incidence of minute streptococci was slightly higher than in normal individuals. 4. In acute streptococcal infections, scarlet fever and acute tonsillitis, for example, the incidence of minute hemolytic streptococci did not significantly vary from the incidence found in normal human beings. 5. Minute beta hemolytic streptococci were found in the throats of 33 out of 42 patients ill with glomerular nephritis and in 25 out of 59 patients who were suffering from the various manifestations of rheumatic fever. 6. In glomerular nephritis and rheumatic infection the minute beta hemolytic streptococci were isolated from the throats of more patients than were the ordinary beta hemolytic streptococci.
Shiga Toxin Subtypes Display Dramatic Differences in Potency

ABSTRACT Purified Shiga toxin (Stx) alone is capable of producing systemic complications, including hemolytic-uremic syndrome (HUS), in animal models of disease. Stx includes two major antigenic forms (Stx1 and Stx2), with minor variants of Stx2 (Stx2a to -h). Stx2a is more potent than Stx1. Epidemiologic studies suggest that Stx2 subtypes also differ in potency, but these differences have not been well documented for purified toxin. The relative potencies of five purified Stx2 subtypes, Stx2a, Stx2b, Stx2c, Stx2d, and activated (elastase-cleaved) Stx2d, were studied in vitro by examining protein synthesis inhibition using Vero monkey kidney cells and inhibition of metabolic activity (reduction of resazurin to fluorescent resorufin) using primary human renal proximal tubule epithelial cells (RPTECs). In both RPTECs and Vero cells, Stx2a, Stx2d, and elastase-cleaved Stx2d were at least 25 times more potent than Stx2b and Stx2c. In vivo potency in mice was also assessed. Stx2b and Stx2c had potencies similar to that of Stx1, while Stx2a, Stx2d, and elastase-cleaved Stx2d were 40 to 400 times more potent than Stx1.
Teachers' role breadth and perceived efficacy in supporting student mental health

Teachers are considered well placed to identify issues concerning students' mental health and well-being and can play a critical role in the helping process for their concerns. However, little is known about the views of teachers regarding their role in supporting student mental health and how well-equipped they feel to fulfil it. The aim of this study was to investigate teachers' perceived role breadth and perceived self-efficacy in supporting students' mental health. Interviews were conducted with 21 teachers from Canberra, Australia. Teachers viewed supporting student mental health as part of their role, though perceived a lack of knowledge and skills in mental health-related areas. They clearly emphasized the need to work within a well-coordinated pastoral care system. Additional training in mental health and clear role delineation within the school may assist teachers to feel better prepared to effectively and appropriately support student mental health.
Spatio–Temporal Adaptation in the Unsupervised Development of Networked Visual Neurons

There have been many computational models mimicking the visual cortex that are based on spatial adaptations of unsupervised neural networks. In this paper, we present a new model called neuronal cluster which includes spatial as well as temporal weights in its unified adaptation scheme. The ldquoin-placerdquo nature of the model is based on two biologically plausible learning rules, Hebbian rule and lateral inhibition. We present the mathematical demonstration that the temporal weights are derived from the delay in lateral inhibition. By training with the natural videos, this model can develop spatio-temporal features such as orientation selective cells, motion sensitive cells, and spatio-temporal complex cells. The unified nature of the adaption scheme allows us to construct a multilayered and task-independent attention selection network which uses the same learning rule for edge, motion, and color detection, and we can use this network to engage in attention selection in both static and dynamic scenes.
Cryoplasty for Canine Iliac Artery Stenosis and its Impact on Expression of TIMP-2 and MMP-2

Objective: This study was performed to observe the effects of cryoplasty on canine iliac artery stenosis and the expression of tissue inhibition of matrix metalloproteinase 2 (TIMP-2) and matrix metalloproteinase 2 (MMP-2). Methods: We produced a reliable canine model to mimic the atherosclerotic stenosis in the iliac artery by suturing the artery followed by vessel ligation to create an injury to intimal and medial walls. Sixteen mongrel dogs with iliac artery stenosis were randomized to conventional balloon angioplasty (n = 8) or cryoplasty (n = 8). Results: Four weeks posttreatment, the cryoplasty group with less collagen fibers and smooth muscle demonstrated significantly larger luminal diameter of iliac artery compared to the balloon angioplasty group (P < .001). Expression of TIMP-2 significantly increased and expression of MMP-2 significantly reduced in iliac artery of the cryoplasty group compared to conventional balloon angioplasty. Conclusion: Our study suggests cryoplasty might increase the expression of TIMP-2 and decrease the expression of MMP-2, thereby inhibiting vascular hyperplasia and collagen fibers synthesis of the stenotic vessels.
Minimum-Volume-Constrained Nonnegative Matrix Factorization: Enhanced Ability of Learning Parts

Nonnegative matrix factorization (NMF) with minimum-volume-constraint (MVC) is exploited in this paper. Our results show that MVC can actually improve the sparseness of the results of NMF. This sparseness is L0-norm oriented and can give desirable results even in very weak sparseness situations, thereby leading to the significantly enhanced ability of learning parts of NMF. The close relation between NMF, sparse NMF, and the MVC_NMF is discussed first. Then two algorithms are proposed to solve the MVC_NMF model. One is called quadratic programming_MVC_NMF (QP_MVC_NMF) which is based on quadratic programming and the other is called negative glow_MVC_NMF (NG_MVC_NMF) because it uses multiplicative updates incorporating natural gradient ingeniously. The QP_MVC_NMF algorithm is quite efficient for small-scale problems and the NG_MVC_NMF algorithm is more suitable for large-scale problems. Simulations show the efficiency and validity of the proposed methods in applications of blind source separation and human face images analysis.