Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvement of the Immunochromatographic NG-Test Carba 5 Assay for the Detection of IMP Variants Previously Undetected

Here, we evaluated the immunochromatographic assay NG-Test Carba 5v2 (NG-Biotech), with improved IMP variant detection on 31 IMP producers, representing the different branches of the IMP phylogeny, including 32 OXA-48, 19 KPC, 12 VIM, 14 NDM, and 13 multiple carbapenemase producers (CPs), 13 CPs that were not targeted, and 13 carbapenemase-negative isolates. All tested IMP variants were accurately detected without impairing detection of the other carbapenemases. ABSTRACT Here, we evaluated the immunochromatographic assay NG-Test Carba 5v2 (NG-Biotech), with improved IMP variant detection on 31 IMP producers, representing the different branches of the IMP phylogeny, including 32 OXA-48, 19 KPC, 12 VIM, 14 NDM, and 13 multiple carbapenemase producers (CPs), 13 CPs that were not targeted, and 13 carbapenemase-negative isolates. All tested IMP variants were accurately detected without impairing detection of the other carbapenemases. Thus, NG-Test Carba 5v2 is now well adapted to countries with high IMP prevalence and to the epidemiology of CP-Pseudomonas aeruginosa, where IMPs are most frequently detected.
Impact of FcγR variants on the response to alemtuzumab in multiple sclerosis

Allelic variants of genes encoding for the Fc gamma receptors IIIA and IIA have been associated with the clinical response to cell‐depleting antibodies in lymphoma patients. Here, we tested the hypothesis that FCGR3A and FCGR2A high‐affinity polymorphisms predict clinical outcomes to alemtuzumab therapy in 85 patients with relapsing‐remitting multiple sclerosis. No differences in clinical and MRI‐based efficacy parameters, the development of severe infusion‐associated reactions and secondary autoimmune diseases during a 2 year follow‐up was observed based on FCGR3A or FCGR2A polymorphisms. This study does not support the use of FCGR genetic variants to predict clinical outcomes to alemtuzumab.
Evaluation of the performance of two strains of Nile tilapia (Oreochromis Niloticus) in mixed raising systems

The aim of this study was to evaluate the productive performance of two strains of Nile tilapia (Oreochromis niloticus) in mixed raising systems. A total of 3600 fish-larvae species was used, 1800 belonging to Bouake lineage, and 1800 to Chitralada. The experiment was carried out in three phases; Phase I in an incubator in 18 boxes, in which two treatments (Bouake and Chitralada) were tested by using nine repetitions; Phases II and III were performed in 18 cement tanks with the same treatments. In phase I, regarding the final weight and gain of weight, Chitralada strain showed the highest final weight values. In phase II, Chitralada showed the highest final weight value when compared with Bouake, and, considering the gain of weight, Bouake obtained the best result. In phase III, Chitralada showed better final weight results (104 days of raising), final weight, final length and gain of length/cm (152 days of raising); but, after 279 days of the cultivation, Bouake showed a higher weight and length gain. These findings showed that Chitralada strain presented the best performance.
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY

Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe significant updates made over the seven releases during the last two years. The database is notably enhanced through the continued linking of relevant pharmacology with key immunological data types as part of the IUPHAR Guide to IMMUNOPHARMACOLOGY (www.guidetoimmunopharmacology.org) and by a major new extension, the IUPHAR/MMV Guide to Malaria PHARMACOLOGY (www.guidetomalariapharmacology.org). The latter has been constructed in partnership with the Medicines for Malaria Venture, an organization dedicated to identifying, developing and delivering new antimalarial therapies that are both effective and affordable. This is in response to the global challenge of over 200 million cases of malaria and 400 000 deaths worldwide, with the majority in the WHO Africa Region. It provides new pharmacological content, including molecular targets in the malaria parasite, interaction data for ligands with antimalarial activity, and establishes curation of data from screening assays, used routinely in antimalarial drug discovery, against the whole organism. A dedicated portal has been developed to provide quick and focused access to these new data.
Renormalization and Hopf algebraic structure of the five-dimensional quartic tensor field theory

This paper is devoted to the study of renormalization of the quartic melonic tensor model in dimension (=rank) five. We review the perturbative renormalization and the computation of the one loop beta function, confirming the asymptotic freedom of the model. We then define the Connes–Kreimer-like Hopf algebra describing the combinatorics of the renormalization of this model and we analyze in detail, at one- and two-loop levels, the Hochschild cohomology allowing to write the combinatorial Dyson–Schwinger equations. Feynman tensor graph Hopf subalgebras are also exhibited.
Development Academy 2010 Inclusive Partnerships for Sustainable Market Innovations

A debate is currently taking place in the microfinance literature between proponents of group loans and those of individual loans. The author argues that capital formation in microfinance programs, especially in the case of female clients, is accelerated by group forces. This paper offers to make a contribution by building up a theoretical model to explain why traditional concepts about gender may need to be revised in the context of microfinance. It also reveals the influence the external environment exerts on loan methodology, a force that is not sufficiently covered by the literature dedicated to microfinance. Loan Methodology, Griffin, 12 July 2010 oikos UNDP Young Scholars Development Academy 2010: Inclusive Partnerships for Sustainable Market Innovations 2 of 39
Learning By Doing and the Choice of Technology

This paper explores a one-agent Bayesian model of learning by doing and technological choice. To produce output, the agent can choose among various technologies. The beneficial effects of learning by doing are bounded on each technology, and so long-run growth in output can take place only if the agent repeatedly switches to better technologies. As the agent repeatedly uses a technology, he learns about its unknown parameters, and this accumulated expertise is a form of human capital. But when the agent switches technologies, part of this human capital is lost. It is this loss of human capital that may prevent the agent from moving up the quality ladder of technologies as quickly as he can, since the loss is greater the bigger is the technological leap. We analyze the global dynamics. We find that a human-capital- rich agent may find it optimal to avoid any switching of technologies, and therefore to experience no long-run growth. On the other hand, a human-capital-poor agent, who because of his lack of skill is not so attached to any particular technology, can find it optimal to switch technologies repeatedly, and therefore enjoy long-run growth in output. Thus the model can give rise to overtaking.
The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction

Aging, as a major risk factor of memory deficiency, affects neural signaling pathways in hippocampus. In particular, age-dependent androgens deficiency causes cognitive impairments. Several enzymes like PKC are involved in memory deficiency. Indeed, PKC regulatory process mediates α-secretase activation to cleave APP in β-amyloid cascade and tau proteins phosphorylation mechanism. Androgens and cortisol regulate PKC signaling pathways, affecting the modulation of RACK1. Mitogen-activated protein kinase/ERK signaling pathway depends on CREB activity in hippocampal neurons and is involved in regulatory processes via PKC and androgens. Therefore, testosterone and PKC contribute in the neuronal apoptosis. The present review summarizes the current status of androgens, PKC, and their influence on cognitive learning. Inconsistencies in experimental investigations related to this fundamental correlation are also discussed, with emphasis on the mentioned contributors as the probable potent candidates for learning and memory improvement.
GENETIC VARIATION AMONG OIL PALM PARENT GENOTYPES AND THEIR PROGENIES BASED ON MICROSATELLITE MARKERS

Knowl­edge on genetic dis­tances and rela­tion­ships among breed­ing mate­ri­als has a sig­nif­i­cant impact on crop improve­ment. Mol­e­c­u­lar mark­ers are being used increas­ingly to deter­mine the genetic dis­tance between indi­vid­u­als. In this study, microsatel­lite mark­ers were used to esti­mate the genetic dis­tances between selected oil palm par­ent lines. Microsatel­lite mark­ers are highly reli­able, inher­ited in codom­i­nant fash­ion whereby het­erozy­gotes and homozy­gotes are dis­tin­guish­able, easy to score and can be rapidly pro­duced using PCR tech­nol­ogy. Nine microsatel­lite mark­ers were used to screen selected par­ent palms (15 duras and 4 pisiferas) and their prog­e­nies (16 DxP crosses). Data were scored and analysed using the Biosys-1 soft­ware to cal­cu­late the genetic dis­tance val­ues. A total of 29 poly­mor­phic bands were gen­er­ated. The genetic dis­tances between prog­e­nies ranged from 0.089 to 0.313. These results indi­cate that microsatel­lite mark­ers are pow­er­ful tools for study­ing genetic rela­tion­ships among DxP prog­e­nies. These mark­ers should be fur­ther explored to assist oil palm breeding.
Corporate Governance and Social Responsibility Aspects in Top Ten IT Companies, in the Context of Globalization

The paper highlights some aspects regarding corporate governance (CG) and corporate social responsibility (CSR) by reviewing the literature and also by investigating these in the context of a sample of companies. We conducted a qualitative research based on observation of some aspects regarding corporate governance and social responsibility in software industry. Information was obtained on the basis of an analysis of last year (2011) reports like: corporate governance codes, corporate social responsibility reports, annual reports, audit reports. To achieve homogeneity of the sample, we choosed top 10 companies from software industry. According to Global Software Top 100, for year 2011, our sample is composed by world's top 10 software companies ranked by annual software revenue. Theoretical and also practical implications consists a basis for future research, seeing the importance of corporate governance and social responsibility.
Quality of Life Is Associated With Wearable-Based Physical Activity in Patients With Inflammatory Bowel Disease: A Prospective, Observational Study

OBJECTIVES: Patient-reported outcomes such as quality of life are gaining importance in the assessment of patients suffering from inflammatory bowel disease (IBD). The association of objectively measured physical activity and quality of life in patients with IBD has not been studied in depth. To investigate the association of disease-specific quality of life and physical activity as well as clinical and biochemical disease activity in patients with IBD. METHODS: A total of 91 patients with IBD were stratified into 4 groups (Crohn's disease and ulcerative colitis, in remission and with moderate-severe activity, respectively) and evaluated in terms of disease-specific quality of life (Inflammatory Bowel Disease Questionnaire [IBDQ]), physical activity (accelerometry), body composition (bioelectrical impedance analysis), as well as clinical (Harvey-Bradshaw Index and Simple Clinical Colitis Activity Index) and biochemical (C-reactive protein and fecal calprotectin) parameters of disease activity. RESULTS: In patients with moderate-severe disease activity, the IBDQ was significantly lower as compared to patients in remission (Mann-Whitney U test and Kruskal-Wallis test, P < 0.001). The physical activity level was higher in remission than in active disease (Mann-Whitney U test, P < 0.05). The IBDQ was significantly correlated with the duration of strenuous physical activity per day (P = 0.029178, r = 0.235), skeletal muscle mass (P = 0.033829, r = 0.229), and biomarkers of inflammation (C-reactive protein: P < 0.005, r = −0.335 and fecal calprotectin: P < 0.005, r = −0.385). DISCUSSION: In this prospective, cross-sectional study, disease-specific quality of life was significantly associated with accelerometrically determined physical activity and disease activity in patients with IBD. This may be related to a reciprocal impact of these factors (DRKS00011370).
Water nanostructure formation on oxide probed in situ by optical resonances

Dynamics of water nanostructure formation on oxide surface is probed in situ by optical resonances. The dynamic characterization of water multilayers on oxide surfaces is hard to achieve by currently available techniques. Despite this, there is an increasing interest in the evolution of water nanostructures on oxides to fully understand the complex dynamics of ice nucleation and growth in natural and artificial environments. Here, we report the in situ detection of the dynamic evolution of nanoscale water layers on an amorphous oxide surface probed by optical resonances. In the water nanolayer growth process, we find an initial nanocluster morphology that turns into a planar layer beyond a critical thickness. In the reverse process, the planar water film converts to nanoclusters, accompanied by a transition from a planar amorphous layer to crystalline nanoclusters. Our results are explained by a simple thermodynamic model as well as kinetic considerations. Our work represents an approach to reveal the nanostructure and dynamics at the water-oxide interface using resonant light probing.
Does Agricultural Trade Liberalization under FTA Reduce Pollution from Agriculture?: The Case of the Japan-Korea FTA

The purpose of this paper is to contribute to the debate over agricultural trade and environment by asking: Does agricultural trade liberalization under free trade agreement (FTA) reduce pollution from agriculture? In order to contribute to answering the above research question, we measure the potential impact of environmental pollution from agriculture caused by agricultural trade liberalization under the Japan-Korea FTA (JKFTA), using the Global Trade Analysis Project (GTAP) model and the OECD Nitrogen Balance Database. The scenario we model assumes the complete removal of all import tariffs between Japan and Korea, not only in the agricultural sector but in non-agricultural sectors, as well. The results show the JKFTA is likely to lead to an overall increase in the total nitrogen surplus for Japan and Korea. Therefore, our results suggest that agricultural trade liberalization under FTA does not reduce the potential pollution from agriculture in the case of the JKFTA.
Emissão de óxido nitroso com a aplicação de dejetos líquidos de suínos em solo sob plantio direto

O objetivo deste trabalho foi comparar as emissoes de oxido nitroso (N2O) para a atmosfera depois da aplicacao de dejetos liquidos de suinos, em plantio direto (PD) e preparo reduzido (PR) do solo. O delineamento experimental utilizado foi o de blocos inteiramente casualizados com cinco repeticoes. Os tratamentos consistiram na aplicacao (40 m3 ha-1), ou nao, de dejetos liquidos em PD e PR. As emissoes de N2O foram medidas in situ depois da aplicacao dos dejetos, por 28 dias. Os fluxos de N2O aumentaram com a aplicacao dos dejetos e, em apenas 20% das avaliacoes realizadas, foram superiores no PD. As emissoes de N2O relacionaram-se com o aumento do espaco poroso ocupado pela agua. Quantidades acumuladas de N na forma de N2O, emitidas em 28 dias, representaram 0,20 e 0,25% do N total aplicado com os dejetos no PD e PR, respectivamente. Os resultados demonstram que a aplicacao de dejetos liquidos de suinos em PD nao aumenta a emissao acumulada de N2O em relacao a aplicacao em PR.
Serum Analysis in Patients with Temporomandibular Disorders: A Controlled Cross-Sectional Study in Norway

Temporomandibular disorder (TMD) is characterized by pain and dysfunction in the temporomandibular join (TMJ) and the masticatory apparatus. Associations with autoimmune diseases, inflammatory conditions, and nutrition deficiencies have been reported in previous studies of TMD patients. To evaluate essential proteins, hormones, electrolytes, and vitamins in serum from TMD patients, a standard blood sample analysis was performed in 60 TMD patients and 60 healthy controls matched for age and gender, retrieving 19 different analyses. We found that TMD patients had significantly higher values of hemoglobin (p=0.036), cobalamin (p=0.023), albumin (p=0.005), parathyroid hormone (PTH) (p=0.038), and vitamin D (p=0.005), and significantly lower values of creatinine (p=0.006) and potassium (p=0.011), compared to controls. In the TMD group, most of the determinants had a wider range, and several subjects, compared to the control group, had values outside the normal reference area. However, most of the TMD patients and controls had values within normal biological range. Our findings could not associate any severe systemic disease, malnutrition, or systemic inflammation with the TMD. Results from our study suggest that serum analyses should neither be used as a biomarker of TMD nor a diagnostic tool for an individual subject with TMD.
Klonów Beds (uppermost Silurian-?lowermost Devonian) and the problem of Caledonian deformations in the Holy Cross Mts.

This paper presents the results of sedimentological, petrographical, stratigraphical and tectonic studies of the Klonow Beds from the Silurian/Devonian boundary interval in the Holy Cross Mts. They have been found in boreholes Klonow 1 and Klonow 2. Alluvial fan, braid plain and braid delta deposits have been recognized and characterized. A facies model has been constructed for the Klonow Beds which interfinger with Miedziana Gora Conglomerates and Bostow Beds. The occurrence of two marine basins, separated by an uplifted area located in the present-day Pasmo Glowne Range, has been evidenced. A detailed lithological description of the cored sedimentary and pyroclastic deposits is given. Mineral composition of greywackes and arenites were analysed allowing determination of the geotectonic character of source areas. The source area for the Klonow and Bostow Beds were different zones of a recycled orogen whereas for the Barcza Beds - mainly a continental block. Palynological studies indicate that the Klonow Beds were deposited during the Pridoli and may correspond to the earliest Gedinnian. The studied rocks have been considered exhibit fault-fold tectonics. Geological processes, which took place at the decline of the Caledonian epoch at the boundary of the Kielce and Łysogory Regions in the Holy Cross Mts. , are described. A problem of molasses representing the decline of the Lower Palaeozoic sedimentary-diastrophic cycle is also discussed. It has been evidenced that the Kielce and Łysogory units had become integrated into the single Holy Cross orogen during the Late Silurian - before the Klonow Beds were deposited, probably during the Ardennian tectonic movements.
Current surgical management of pelvic organ prolapse: Strategies for the improvement of surgical outcomes

There are a variety of surgical management strategies to help surgeons repair pelvic organ prolapse (POP). Surgical treatment for POP includes native tissue repair, augmentation with mesh, and minimally invasive surgeries. Currently, laparoscopic or robotic techniques for POP repair are increasing in popularity and continuing to evolve. The aim of this review is to present an up-to-date review of surgical techniques used for POP repair and to discuss ways to optimize surgical outcomes.
RF power tests of LEP2 main couplers on a single cell superconducting cavity

To determine the power capability of the input couplers for the LEP2 superconducting (SC) cavities a new test set-up has been built. The new set-up permits tests at high RF power levels under realistic conditions (cooled-down SC caw? )$ The couplers have been exposed to high RF po wer in matched and unmatched CW conditions as well as in pulsed operation. Power levels of more than 500 kW C W have been reached
Development of Universal Influenza Vaccines Targeting Conserved Viral Proteins

Vaccination is still the most efficient way to prevent an infection with influenza viruses. Nevertheless, existing commercial vaccines face serious limitations such as availability during epidemic outbreaks and their efficacy. Existing seasonal influenza vaccines mostly induce antibody responses to the surface proteins of influenza viruses, which frequently change due to antigenic shift and or drift, thus allowing influenza viruses to avoid neutralizing antibodies. Hence, influenza vaccines need a yearly formulation to protect against new seasonal viruses. A broadly protective or universal influenza vaccine must induce effective humoral as well as cellular immunity against conserved influenza antigens, offer good protection against influenza pandemics, be safe, and have a fast production platform. Nanotechnology has great potential to improve vaccine delivery, immunogenicity, and host immune responses. As new strains of human epidemic influenza virus strains could originate from poultry and swine viruses, development of a new universal influenza vaccine will require the immune responses to be directed against viruses from different hosts. This review discusses how the new vaccine platforms and nanoparticles can be beneficial in the development of a broadly protective, universal influenza vaccine.
Impact of nitrogen and spacing on the growth and yield of okra [Abelmoschus esculentus (L.) Moench]

The present investigations entitled “Impact of nitrogen and spacing on the growth and yield of okra” was carried out during spring summer season 2015. The applications of nitrogen at 100 kg/ha recorded higher yield attributes of the number of nods per plant, leaves per plant, internodes length, plant height, pod length, number of pods per plant, fruit yield per plant and total green pod yield per hectare. Nitrogen application upto125 kg/ha significantly decrease the days to 50% flowering. The pod weight, pod length, number of nodes per plant, number of pods per plant, fruit yield per plant and total green pod yield per hectare increased higher with the optimum plant to plant spacing of 15 cm. The data revealed the interaction between nitrogen level and plant density was present in case of plant growth and yield contributing characters of okra. Although the highest level interaction of 100 kg N/ha with plant to plat spacing 15 cm produced the high number of nods per plant, pod weight, pod length, number of pods per plant, pod yield per plant and total green pod yield per hectare and the days to 50% flowering decreased was recorded with 125 kg N/ha and plant to plant spacing 20 cm. The highest gross return (Rs.94080) and net return (Rs.84621.3) were obtained from N125S20.