Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimisation du dimensionnement d’une chaîne de conversion électrique directe incluant un système de lissage de production par supercondensateurs : application au houlogénérateur SEAREV

Le travail presente dans cette these porte sur l'etude du dimensionnement d'une chaine de conversion electrique en entrainement direct d'un systeme direct de recuperation de l'energie des vagues (searev). Cette chaine de conversion est composee d'une generatrice synchrone a aimants permanents solidaire d'un volant pendulaire, d'un convertisseur electronique compose de deux ponts triphases a modulation de largeur d'impulsion, l'un controlant la generatrice, l'autre permettant d'injecter l'energie electrique au reseau. En complement, un systeme de stockage de l'energie (batterie de supercondensateurs) est destine au lissage de la puissance produite. Le dimensionnement de tous ces elements constitutifs necessite une approche d'optimisation sur cycle, dans un contexte de fort couplage multi-physique notamment entre les parties hydrodynamique et electromecanique. Dans un premier temps, l'ensemble generatrice-convertisseur, dont le role est d'amortir le mouvement d'un volant pendulaire interne, est optimise en vue de minimiser le cout de production de l'energie (cout du kWh sur la duree d'usage). Cette optimisation sur cycle est realisee en couplage fort avec le systeme houlogenerateur grâce a la prise en compte conjointe de variables d'optimisation relatives a l'ensemble convertisseur-machine mais aussi a la loi d'amortissement du volant pendulaire. L'integration d'une strategie de defluxage, interessante pour assurer un fonctionnement en ecretage de la puissance, permet, des l'etape de dimensionnement, de traiter l'interaction convertisseur-machine. Dans un second temps, la capacite energetique du systeme de stockage de l'energie fait l'objet d'une optimisation en vue de la minimisation de son cout economique sur cycle de vie. Pour ce faire, nous definissons des criteres de qualite de l'energie injectee au reseau, dont un lie au flicker, et nous comparons des strategies de gestion de l'etat de charge tout en tenant compte du vieillissement en cyclage des supercondensateurs du a la tension et a leur temperature. Dans un troisieme temps, a partir de donnees d'etats de mer sur une annee entiere, nous proposons des dimensionnements de chaines de conversion electrique qui presentent les meilleurs compromis en termes d'energie totale recuperee et de cout d'investissement.
Tumor necrosis factor-alpha increases in the brain after intracerebral hemorrhage and thrombin stimulation.

OBJECTIVE The goals of this study were 1) to determine the effects of intracerebral hemorrhage (ICH) on brain tumor necrosis factor (TNF)-alpha levels, which are still controversial; 2) to investigate the role of TNF-alpha in ICH-induced brain injury; 3) to examine the effects of thrombin on brain TNF-alpha levels; and 4) to elucidate the role of TNF-alpha in thrombin-induced neuroprotection. METHODS Autologous whole blood and thrombin were injected into the right caudate of rats or mice. Brain TNF-alpha was then determined by enzyme-linked immunosorbent assay and immunohistochemistry. Brain edema and neurological deficits were also examined. RESULTS Perihematomal TNF-alpha levels increased after ICH. ICH-induced brain edema was less in TNF-alpha knockout mice compared with wild-type mice (P < 0.05). Intracerebral infusion of thrombin also caused an increase in brain TNF-alpha levels. Thrombin preconditioning reduced thrombin-induced brain edema, but this effect was not blocked by a neutralizing TNF-alpha antibody. CONCLUSION Increase of perihematomal TNF-alpha levels contributes to brain edema formation after ICH. Thrombin may be a major mediator of ICH-induced TNF-alpha production, but thrombin-induced brain tolerance may not be TNF-alpha mediated.
Identification of bacteria selected for biocontrol of damping-off disease and plant growth promotion

Three isolates of rhizosphere bacteria, which had been selected previously for their efficacy to control damping-off diseases in bedding plants, were subjected to various tests to determine their identity. One isolate was identified as Bacillus amyloliquefaciens Fukumoto 1943 and the other two as Pseudomonas putida (Trevisan 1889) Migula 1895.
Predicting eukaryotic protein subcellular location by fusing optimized evidence-theoretic K-Nearest Neighbor classifiers.

Facing the explosion of newly generated protein sequences in the post genomic era, we are challenged to develop an automated method for fast and reliably annotating their subcellular locations. Knowledge of subcellular locations of proteins can provide useful hints for revealing their functions and understanding how they interact with each other in cellular networking. Unfortunately, it is both expensive and time-consuming to determine the localization of an uncharacterized protein in a living cell purely based on experiments. To tackle the challenge, a novel hybridization classifier was developed by fusing many basic individual classifiers through a voting system. The "engine" of these basic classifiers was operated by the OET-KNN (Optimized Evidence-Theoretic K-Nearest Neighbor) rule. As a demonstration, predictions were performed with the fusion classifier for proteins among the following 16 localizations: (1) cell wall, (2) centriole, (3) chloroplast, (4) cyanelle, (5) cytoplasm, (6) cytoskeleton, (7) endoplasmic reticulum, (8) extracell, (9) Golgi apparatus, (10) lysosome, (11) mitochondria, (12) nucleus, (13) peroxisome, (14) plasma membrane, (15) plastid, and (16) vacuole. To get rid of redundancy and homology bias, none of the proteins investigated here had >/=25% sequence identity to any other in a same subcellular location. The overall success rates thus obtained via the jack-knife cross-validation test and independent dataset test were 81.6% and 83.7%, respectively, which were 46 approximately 63% higher than those performed by the other existing methods on the same benchmark datasets. Also, it is clearly elucidated that the overwhelmingly high success rates obtained by the fusion classifier is by no means a trivial utilization of the GO annotations as prone to be misinterpreted because there is a huge number of proteins with given accession numbers and the corresponding GO numbers, but their subcellular locations are still unknown, and that the percentage of proteins with GO annotations indicating their subcellular components is even less than the percentage of proteins with known subcellular location annotation in the Swiss-Prot database. It is anticipated that the powerful fusion classifier may also become a very useful high throughput tool in characterizing other attributes of proteins according to their sequences, such as enzyme class, membrane protein type, and nuclear receptor subfamily, among many others. A web server, called "Euk-OET-PLoc", has been designed at http://202.120. 37.186/bioinf/euk-oet for public to predict subcellular locations of eukaryotic proteins by the fusion OET-KNN classifier.
RRS1, a Conserved Essential Gene, Encodes a Novel Regulatory Protein Required for Ribosome Biogenesis inSaccharomyces cerevisiae

ABSTRACT A secretory defect causes specific and significant transcriptional repression of both ribosomal protein and rRNA genes (K. Mizuta and J. R. Warner, Mol. Cell. Biol. 14:2493–2502, 1994), suggesting the coupling of plasma membrane and ribosome syntheses. In order to elucidate the molecular mechanism of the signaling pathway, we isolated a cold-sensitive mutant with a mutation in a gene termedRRS1 (regulator of ribosome synthesis), which appeared to be defective in the signaling pathway. The rrs1-1 mutation greatly reduced transcriptional repression of both rRNA and ribosomal protein genes that is caused by a secretory defect. RRS1 is a novel, essential gene encoding a nuclear protein of 203 amino acid residues that is conserved in eukaryotes. A conditionalrrs1-null mutant was constructed by placingRRS1 under the control of the GAL1 promoter. Rrs1p depletion caused defects in processing of pre-rRNA and assembly of ribosomal subunits.
Claw retraction and protraction in the Carnivora: the cheetah ( Acinonyx jubatus ) as an atypical felid

The cheetah Acinonyx jubatus is the most cursorial felid and has been described as somewhat dog-like in both the shape and the diminished degree of retraction of the claws. In this study we evaluate and investigate the osteological correlates associated with claw retraction in the cheetah through a comparison of the morphology of its middle phalanges with those of other felids and of the wolf Canis lupus. Compared to other felids, the middle phalanges of the cheetah have better-developed grooving of the distal articulatory facets in both the manus and pes, reduced to absent angulation to the distal articulatory facets in the inner and outer digits, less marked asymmetry of the shaft, and a mid-shaft cross-section that is less triangular and more circular. In all of these features, the morphology of the cheetah is intermediate between that of other felids and that of the wolf. The cheetah’s distinctive morphology is autapomorphic within Felidae and similarities between the cheetah and the wolf are the result of convergence. Study of an ontogenetic series of specimens of the domestic cat suggests that the morphology of the cheetah can be explained, at least in part, as a product of heterochrony in which the development of the middle phalanx is truncated at an earlier stage than is typical of the adults of other felids. Some of the morphological differences in the middle phalanges of the cheetah can be associated with its distinctive hunting behaviour. The reduced manipulative capabilities of the forelimb associated with the evolution of cursorial adaptations seem to have limited the roles of the forepaws in both the subduing of prey and feeding.
Co‐inheritance of the Hb Sun Prairie mutation with a point mutation at 5′‐UTR in the eastern Indian population

Haemoglobin (Hb) Sun Prairie (α2‐globin cd130, GCT→CCT, Ala→Pro) is detected in three unrelated chromosomes, in association with a C→T transition in the 5′‐untranslated region (UTR), two bases upstream from the translation start site. Reported inversion of α/β‐mRNA ratio observed in Hb Sun Prairie mutants might stem from the second mutation and should be investigated. Molecular modelling studies indicate that the 130th residue of α‐globin faces primarily the central cavity of the molecule and is not in contact with any β‐chain residue; further, no significant disruption of the Hb structure because of the Sun Prairie mutation is discernible. Depression of translation because of the second mutation of a conserved base in the 5′‐UTR might explain the observed clinical severity.
Sentinel node detection using 99mTc-rhenium sulphide colloid in breast cancer patients: evaluation of 1 day and 2 day protocols, and a dose-finding study

Sentinel node (SN) biopsy is a promising replacement for standard axillary lymph node dissection for the staging of early breast cancer, and various techniques have been studied to identify SNs with dye or radioactive colloid. This study assesses the effect of the dose of radioactivity and the time before biopsy in order to set standards for the use of 99mTc-rhenium sulphide for the detection of SNs in breast cancer patients. Sixty patients with stage T1-2 N0 M0 breast cancer underwent SN biopsy, which was immediately followed by standard axillary dissection to confirm the SN results. For SN biopsy, 99mTc-rhenium colloid was injected peritumorally. A 1 day (morning injection and afternoon surgery) or 2 day (day before afternoon injection and morning surgery) protocol was applied. A dose-finding study was performed simultaneously using 7.4-37 MBq for the 1 day protocol and 37-74 MBq for the 2 day protocol. A scintigram was taken at 2 h for the 1 day protocol and 16 h for the 2 day protocol. After the injection of blue dye, SN biopsy was performed with a gamma probe, followed by standard axillary node dissection. The radiation exposure received by the surgical team during the operation was monitored. Histopathological comparison between SNs and axillary nodes was performed. Patient characteristics that might affect the radiocolloid uptake by SNs were assessed. SNs were identified in all patients regardless of the dose or administration protocol used. Two patients showed false negative pathological SN results, and the negative predictive value was 96% and the positive predictive value was 100%. In addition, radiation exposure to the surgical team and the amount of radioactive surgical waste were low, especially at lower doses. Two groups of patient characteristics were related to SN uptake. One was the body mass index (BMI) and the other was the age or menopausal status. Patients with a larger BMI tended to take up a smaller amount of 99mTc colloid. Older or post-menopausal patients showed lower SN uptake. 99mTc-rhenium sulphide colloid is an efficient radiopharmaceutical for SN detection. Both 1 day and 2 day protocols have equally good efficacy, and the recommended dose is 7.4 MBq for the 1 day protocol and 37 MBq for the 2 day protocol. Patients with larger BMI and older or post-menopausal patients tend to take up less 99mTc colloid.
Separating top-down and bottom-up cueing of attention from response inhibition in utilization behavior

A single case study of a patient (FK) with utilization disorder following bilateral damage to medial frontal and anterior temporal cortices is reported. FK had to localize a search target following presentation of an earlier verbal or visual cue. Search was strongly affected by semantic/visual associations between the cue and search items. Although FK was unable to name the hue of an incongruent Stroop word, his attention was drawn to a color in the display matching the hue of the cue word. FK's ability to inhibit a response activated by the cueing of attention was impaired. There is dissociation between top-down attention cueing and response inhibition.
Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival.

BACKGROUND The impact of cytomegalovirus (CMV) infection and disease on long-term outcome after kidney transplantation is still unsettled. METHODS Between 1994 and 1997, 397 consecutive first kidney graft recipients and 74 retransplants were included in the study and followed prospectively until December 31, 2001. CMV infection (CMV pp65 antigenemia) and CMV disease were recorded once weekly during the first 100 days after transplantation. No CMV prophylaxis or preemptive therapy was given. In a multiple Cox proportional hazard model allowing time-dependent covariates, the effects of asymptomatic CMV infection and CMV disease, recipient age and gender, retransplantation, living donor, panel-reactive cytotoxid antibodies, acute rejection, and graft loss were tested on overall mortality beyond 100 days post-transplantation. In a similar analysis, the effect of asymptomatic CMV infection and CMV disease plus other factors were tested on death censored graft loss beyond 100 days. RESULTS Median (range) follow up time was 66.6 (<1-86.9) months. The incidence of CMV infection and disease during the first 100 days was 62.8% and 23.4%, respectively. The number of total deaths was 96 (20%), 82 occurred after the first 100 days. Independent risk factors for overall mortality beyond 100 days were asymptomatic CMV infection, RR = 2.90 (95% CI 1.61-5.22) (P= 0.001), CMV disease, RR = 2.50 (95% CI 1.31-4.79) (P= 0.006), both compared to no infection or disease, recipient age, RR = 1.066 per year (95% CI 1.048-1.084) (P < 0.001), and graft loss in the whole study period RR = 7.88 (95% CI 4.75-13.08) (P < 0.001). Asymptomatic CMV infection and CMV disease were not independent risk factors for death censored graft loss, but they significantly reduced graft survival uncensored for death, (log rank P= 0.001, respectively). CONCLUSION Asymptomatic CMV infection and overt CMV disease during the first 100 days increase the risk of recipient mortality beyond 100 days. This raises the question whether CMV prophylaxis should be given routinely after kidney transplantation.
Investigating the Empirical Relationship between Service Quality, Trust, Satisfaction, and Intention of Customers Purchasing Life Insurance Products

The purpose of this paper was to identify the key SERVQUAL factors for consumer purchase intention in the context of life insurance products in Malaysia. The study was performed based on primary data using a self-administered questionnaire from the Klang valley region of Malaysia. Using a cross-sectional study, a total of 215 usable responses were collected using convenience sampling technique. To measure customer satisfaction, trust, and purchase intention, seven key SERVQUAL factors were utilized, that is, tangibility, reliability, responsiveness, assurance, empathy, helpfulness, and problem solving. Data were analyzed using a 5-point Likert scale. Descriptive statistics & exploratory and confirmatory factor analysis were employed. The findings revealed that customer satisfaction and trust together with SERVQUAL factors lead to purchase intention. Conversely, this paper also found that life insurance agents with problem-solving skills and helpfulness will lead to an increase in customers' intention to purchase life insurance products. From the validation of the framework, it is obvious to make sure that all the quality functions must be in accordance with increasing competitive advantage along with the organizational objectives.
Assessment of Quantity Surveying Firms' Process and Product Innovation Drive in Nigeria

Purpose- Innovation repositions and strengthens the competitive advantage and revenue drive of corporate businesses. The aim of this study is to assess the extent of the process and product innovation in Nigerian Quantity Surveying firms with a view to determining the innovative tools/concepts used. Design/Methodology- The study adopted a questionnaire survey in which simple random sampling was used to collect data from Quantity Surveyors working with Quantity Surveying firms in the study area. Relative importance Index, mean score, frequencies, andpercentages were used to analyze the data collected, and Rogers' innovation adopters categorization was employed to determine the level of adoption of innovation by Quantity Surveyors. Findings- The study found that Quantity Surveying firms do not engage the services of innovation specialist because of financial constraint. The most adopted innovative tools/concept by Quantity Surveying firms are MS Excel, Computer Aided Taking-off, CATO, and CA Estimating, and these firms are an early majority in the adoption of process and product/technological innovations. Practical Implications- The study would assist Quantity Surveying firms who have notembraced innovation to do so, by adopting and incorporating innovative practices in the running of the business transactions and operations to improve clients' satisfaction, profit generation, andcompany image.
Behavioral Intention of Consumer Towards The Existence of Go-Food

ABSTRACTThe existence of e-commerce in Indonesia makes it easy for everyone to access and get the products or services they need. One of the e-commerce game changers in Indonesia is GO-JEK which also drives Go-Food as the largest food delivery service currently in Indonesia. This study aims to determine the value of customers to Hedonic Motivation variables, prior Online Purchasing Experience, Time Savings Orientation, and Price Savings Orientation, Motivational Comfort and Usage Utility, Attitude to Online Food Delivery Service (AODS). Behavior Intention on Online Food Delivery Service (BIOFDS), Convenience Motivation, Affects Usage Post-Use. And to know Attitude variable to Online Food Delivery Service. Purposive sampling was used in this study with 400 valid questionnaires which contain 29 items question that have been distributed online. Partial Least Square (PLS) was used in this study. Two variables, price saving orientation to convenience motivation and convenience motivation towards attitude have no positive effect. Convenience motivation has the biggest positive relationship to behavioral intention towards online food delivery service.Keywords: convenience motivation, post-usage usefulness, attitude towards online food delivery system, behavioral intention towards food delivery system ABSTRAKKeberadaan e-commerce di Indonesia memudahkan semua orang untuk mengakses dan mendapatkan produk atau layanan yang mereka butuhkan. Salah satu pengubah permainan e-commerce di Indonesia adalah GO-JEK yang juga menjadikan Go-Food sebagai layanan pengiriman makanan terbesar saat ini di Indonesia. Penelitian ini bertujuan untuk menentukan nilai pelanggan terhadap variabel Motivasi Hedonic, Pengalaman Pembelian Online sebelumnya, Orientasi Penghematan Waktu, dan Orientasi Penghematan Harga, Kenyamanan Motivasi dan Utilitas Penggunaan, Sikap terhadap Layanan Pengiriman Makanan Online (AODS). Niat Perilaku pada Layanan Pengiriman Makanan Online (BIOFDS), Motivasi Kenyamanan, Mempengaruhi Penggunaan Pasca Penggunaan. Dan untuk mengetahui variabel Attitude terhadap Layanan Pengiriman Makanan Online. Purposive sampling digunakan dalam penelitian ini dengan 400 kuesioner yang valid yang berisi 29 item pertanyaan yang telah didistribusikan secara online. Partial Least Square (PLS) digunakan dalam penelitian ini. Dua variabel, orientasi penghematan harga untuk motivasi kenyamanan dan motivasi kenyamanan terhadap sikap tidak memiliki efek positif. Motivasi kenyamanan memiliki hubungan positif terbesar dengan niat perilaku terhadap layanan pengiriman makanan online.Kata Kunci: motivasi kenyamanan, kegunaan pasca penggunaan, sikap terhadap sistem pengiriman makanan online, niat perilaku terhadap sistem pengiriman makanan
Errors in drug administration by anaesthetists in public hospitals in the Free State.

OBJECTIVE To investigate errors in administering drugs by anaesthetists working in public hospitals in the Free State province. METHODS Anonymous questionnaires were distributed to doctors performing anaesthesia in public hospitals in the Free State, i.e. 188 doctors at 22 public sector hospitals. Outcomes included demographic information on respondents, information regarding the administration of anaesthetics, reporting of errors, and the occurrence of errors during anaesthesia. RESULTS The response rate was 46.3%; 48.8% were medical officers, and 39.3% of participants were involved in at least one event of erroneous drug administration. Registrars and specialists reported the most errors. Most events were of no clinical significance, caused no permanent harm to patients, and most commonly involved fentanyl and suxamethonium. Of the respondents, 23.8% indicated that they were aware of a South African standard for colour-coding syringe labels, and 92.9% indicated that they would report anaesthetic errors if a single reporting agency for such events existed. CONCLUSIONS. More than a third of participating anaesthetists were involved in a drug error at some stage in their practice. Preventive systems and precautionary measures should be put in place to reduce drug administration errors.