Miracle-dz/UniFAR-FTUs huggingface dataset:
Adjuvant Chemotherapy with High-Dose Cyclophosphamide, Etoposide and Cisplatin Intensification without Progenitor Cell Support in Breast Cancer Patients with Ten or More Involved Nodes: 5-Year Results of a Pilot Trial

Objectives: The purpose of this study was to evaluate the clinical efficacy and tolerability of high-dose (HD) chemotherapy with growth factor support in primary breast cancer with extensive nodal involvement. Patients and Methods: Fifty-three patients with ten or more involved nodes were recruited and were given three cycles of standard-dose fluorouracil, epidoxorubicin and cyclophosphamide followed by one single course of high-dose CEP (cyclophosphamide, etoposide and cisplatin). No autologous progenitor support was used. Results: Five-year actuarial disease-free and overall survival were 40 and 60%, respectively. High-dose CEP required a median of 22 days of hospitalization and was associated with grade G3–G4 nausea and vomiting in two thirds of the cases. Hematological toxicity was comparable to that of high-dose therapies delivered with autologous progenitor support. No therapy-related mortality was observed. Conclusions: The efficacy of treatment was comparable to the best results of conventional therapy, with only a trend for improved survival. High-dose CEP was feasible with acceptable toxicity. Although this regimen does not require stem cell harvesting and storage, it requires clinical support comparable to autotransplantation procedures and side effects are not so manageable to recommend its use outside specialized units.
Neurofibroma of the parapharyngeal space

Solitary neurofibroma and carotid body tumour thus form the commonest of these raie but interesting swellings encountered in the upper part of the neck. Their clinical differentiation may be quite impossible and in some quarters these tumours are jegarded as being related, an opinion in keeping with the widely held but debatable view that the carotid body tumour is of neural origin (Cullen and Monro, 1952). Solitary neurofibroma of the parapharyngeal space can, rarely, protrude into the lateral wall of the pharynx without being detectable in the neck. Only two such cases have been reported by Lukovskii and Dzyza (1962). The present case of ours also came with a swelling in the pharynx in the peritonsillar region.
A Frequency-Domain Algorithm for Dynamic Synchrophasor and Frequency Estimation

Next-generation phasor measurement units (PMUs) are expected to play a key role for monitoring the behavior of future smart grids. While most of the PMUs used nowadays in transmission networks rely on static phasor models, more sophisticated representations and stricter accuracy requirements are needed to track amplitude, phase, and frequency changes of power waveforms in strongly dynamic scenarios as those expected in future distribution systems. In this paper, a discrete Fourier transform (DFT)-based algorithm based on a dynamic phasor model (referred to as interpolated dynamic DFT-based synchrophasor estimator) is used to estimate not only amplitude and phase of the collected waveforms, but also their frequency and rate of change of frequency. The performances of the proposed method are evaluated through multiple simulations in different steady-state and transient conditions described in the Standard IEEE C37.118. 1-2011.
Diagnosis of adenocarcinoma in prostate needle biopsy tissue

Prostate cancer is a major public health problem throughout the developed world. For patients with clinically localised prostate cancer, the diagnosis is typically established by histopathological examination of prostate needle biopsy samples. Major and minor criteria are used to establish the diagnosis, based on the microscopic appearance of slides stained using haematoxylin and eosin. Major criteria include an infiltrative glandular growth pattern, an absence of basal cells and nuclear atypia in the form of nucleomegaly and nucleolomegaly. In difficult cases, basal cell absence may be confirmed by immunohistochemical stains for high-molecular-weight cytokeratins (marked with antibody 34βE12) or p63, which are basal cell markers. Minor criteria include intraluminal wispy blue mucin, pink amorphous secretions, mitotic figures, intraluminal crystalloids, adjacent high-grade prostatic intraepithelial neoplasia, amphophilic cytoplasm and nuclear hyperchromasia. Another useful diagnostic marker detectable by immunohistochemistry is α-methylacyl coenzyme A racemase (AMACR), an enzyme selectively expressed in neoplastic glandular epithelium. Cocktails of antibodies directed against basal cell markers and AMACR are particularly useful in evaluating small foci of atypical glands, and in substantiating a diagnosis of a minimal adenocarcinoma. Reporting of adenocarcinoma in needle biopsy specimens should always include the Gleason grade and measures of tumour extent in the needle core tissue. Measures of tumour extent are (1) number of cores positive for cancer in the number of cores examined, (2) percentage of needle core tissue affected by carcinoma and (3) linear millimetres of carcinoma present.
Appropriate or Remix? The Effects of Social Recognition and Psychological Ownership on Intention to Share in Online Communities

Even though negative aspects of making use of others’ work, such as illegal appropriation, have been found in online communities, remixing is considered a type of constructive creation for generating and recreating creative works. To make constructive creation via remixing sustainable, it is critical for users to share their own creations and allow others to use them in these online communities. We propose psychological ownership and social recognition as key antecedents for original creators to increase their intention to share their works in an online remix context. In this study, we aim to examine the relationships between intention to share, psychological ownership, and social recognition. To investigate the effects of psychological ownership and social recognition on intention to share, we proposed research hypotheses based on the theories of social recognition and psychological ownership. Prior to testing the hypotheses, we conducted a preliminary study including user interviews and community log analysis within an online remix community. Specific patterns of psychological ownership and social recognition in the online remix context were found in accordance with the theoretical background. The results from the preliminary study were applied to forms of apparatus and stimuli in the following experiment. A quasi-experiment was designed to test hypotheses of causal relationships between the key factors. A prototype of an online remix community for smartphone themes was developed based on the detailed findings of the preliminary study and utilized as an experimental apparatus. Sixty-nine participants carried out our experimental procedure of creating, sharing their own work, checking responses from others, and reporting their intention to share their future creations. The results of the quasi-experiment supported all our research hypotheses. Social recognition was found to increase the intention to share. Moreover, psychological ownership was found to increase the intention to share, an observation that may seem at odds with the exclusive aspects of ownership found in prior studies. More interesting, the positive effect of social recognition on intention to share becomes stronger with a higher perception of psychological ownership. This article ends with theoretical and practical implications of the study results.
[Validation of an instrument to monitor food insecurity in Sierra de Manantlán, Jalisco].

OBJECTIVE To validate a version of the Food Security Scale (FSS) in communities located in Sierra de Manantlán, Jalisco. MATERIAL AND METHODS Using focus groups, the FSS was modified to fit the Mexican context. Subsequently, a survey was applied to women with pre-school aged children. The FSS was validated in correlation with a household food inventory and the dietary variety of the individual being interviewed. The interview also included a socioeconomic questionnaire. RESULTS Forty-four percent of the households reported mild food insecurity, 33% reported moderate hunger and 19.7% reported severe hunger. Food insecurity was significantly and inversely correlated with the number of food items in the household (r=-0.36**), animal source foods (r=-0.28**), dairy products (r=-0.25*), processed foods (r=-0.37**), fruits (r=-0.21*), and vegetables (r=-0.28**); *p<0.05, **p< 0.01. Food insecurity was also associated with low dietary variety (r=-0.23, p=0.02). These associations were maintained in multivariate models. CONCLUSIONS The FSS is a useful tool for monitoring food insecurity in rural regions of Jalisco.
Conventional And Robust Paired And Independent-Samples t Tests: Type I Error And Power Rates

Monte Carlo methods were used to examine Type I error and power rates of 2 versions (conventional and robust) of the paired and independent-samples t tests under nonnormality. The conventional (robust) versions employed least squares means and variances (trimmed means and Winsorized variances) to test for differences between groups.
Compare the safety and efficacy of endoscopic third ventriculostomy and ventriculoperitoneal shunt placement in infants and children with hydrocephalus: a systematic review and meta-analysis

Abstract Purpose Endoscopic third ventriculostomy (ETV) and ventriculoperitoneal shunt placement are two surgical options used for treatment of non-communicating hydrocephalus. The purpose of this study was to compare the efficiency and safety of these techniques in pediatric patients. Materials and methods An extensive literature review regarding the clinical outcome, safety and efficiency of ETV and shunting in treatment of hydrocephalus was conducted in Medline, PubMed, Cochrane and Google Scholar databases up to 27 November 2015. Patient demographics, ETV and shunting success and failure rates were extracted. Results A total of seven two-arm studies were included for quantitative analysis and 25 single-arm studies were included for systematic review. The two-arm studies recruited a total of 6995 patients: 1046 in the ETV group and 5949 in the shunt group. The pooled results showed that the 1 year success rate of ETV and shunt-placement procedure were similar (pooled RR = 0.870, 95% CI = 0.680–1.112, P = 0.266). The failure rate in the ETV treatment group was 0.9 times higher than in the shunt group; however, the results did not reach statistical significance (pooled RR = 0.893, 95% CI = 0.576–1.383, P = 0.611). Conclusions Both ETV and shunts are associated with similar 1 year success and failure rates. Therefore, there are no current indications to recommend one mode of treatment over the other. Future studies designed to assess the effectiveness of ETV and shunt procedures depending on patient’s age and etiology are warranted.
Acetoacetate and Glucose as Lipid Precursors and Energy Substrates in Primary Cultures of Astrocytes and Neurons from Mouse Cerebral Cortex

Abstract: Primary cultures of astrocytes and neurons derived from neonatal and embryonic mouse cerebral cortex, respectively, were incubated with [3‐14C]acetoacetate or [2‐14C]glucose. The utilization of glucose and acetoacetate, the production of lactate, d‐3‐hydroxybu‐tyrate, and 14CO2 and the incorporation of 14C and of 3H from 3H2O into lipids and lipid fractions were measured. Both cell types used acetoacetate as an energy substrate and as a lipid precursor; lactate was the major product of glucose metabolism. About 60% of the acetoacetate that was utilized by neurons was oxidized to CO2, whereas this was only ∼20% in the case of cultured astrocytes. This indicates that the rate at which 14C‐labeled Krebs cycle intermediates exchange with pools of unlabeled intermediates is much higher in astrocytes than in neurons. Acetoacetate is a better precursor for the synthesis of fatty acids and cholesterol than glucose, presumably because it can be used directly in the cytosol for these processes; preferential incorporation into cholesterol was not observed in these in vitro systems. We conclude that ketone bodies can be metabolized both by the glial cells and by the neuronal cells of developing mouse brain.
The role of parasite–induced immunodepression, rank and social environment in the modulation of behaviour and hormone concentration in male laboratory mice (Mus musculus)

Peripheral immune responsiveness in male laboratory mice was reduced by infection with the trichostrongyloid nematode Heligmosomoides polygyrus. Responsiveness was also lower among high–ranking (aggressive) males regardless of infection status. Reduced responsiveness in both infected animals and high rankers was associated with elevated serum corticosterone concentration (a potential immunodepressant) and was compounded among high–ranking males by subsequent high aggressiveness. As in previous experiments, only low rankers modulated testosterone secretion in relation to current immunocompetence and corticosterone concentration. The lack of any downregulation of aggression in response to parasite–induced immunodepression contrasted with previous results using antithymocyte serum and may be due to the more localized nature of immunodepression during H. polygyrus infection. However, the additional increase in corticosterone concentration resulting from exposure to female odour and destabilized aggressive social relationships did result in downregulation of aggression among high rankers and of testosterone among mice generally, suggesting that modulation rules of thumb are at least partly dependent on the proximate cues associated with immunodepression.
Decreased protein binding of mycophenolic acid associated with leukopenia in a pancreas transplant recipient with renal failure.

BACKGROUND Mycophenolate mofetil (MMF) is rapidly hydrolyzed to its active metabolite mycophenolic acid (MPA), which is excreted by the kidney after undergoing glucuronidation to MPAG. MPAG has been shown to accumulate in patients with renal failure. MPA is extensively and avidly bound to human serum albumin. In vitro inhibition of the pharmacologic target, inosine monophosphate dehydrogenase, is dependent on free MPA. It has been demonstrated that high MPAG concentrations decrease MPA protein binding in vitro. In addition, the uremic state is associated with altered protein binding of many drugs. METHODS We assessed free MPA, total MPA, and MPAG kinetics in a patient with renal failure receiving MMF for a pancreas transplant, who presented with signs of MMF toxicity. MPA, MPAG, and free MPA were measured by high performance liquid chromatography and a validated 14C-MPA ultrafiltration methodology. RESULTS The MPAG area under the concentration curve (AUC) in this patient was extremely high (5899 microg x hr/ml). The total MPA AUC of 36.8 microg x hr/ml was within the range usually obtained in stable renal patients. The free fraction of MPA and the free MPA AUC were markedly elevated (13.8% and 5.07 microg x hr/ml, respectively). CONCLUSIONS Patients with severe renal insufficiency may have markedly increased free MPA levels that may not be reflected in total MPA concentrations. These patients may be at increased risk for MMF-related toxicity.
Generalized theory of förster-type nonradiative energy transfer in nanostructures with mixed dimensionality

Forster-type nonradiative energy transfer (NRET) is widely used, especially utilizing nanostructures in different combinations and configurations. However, the existing well-accepted Forster theory is only for the case of a single particle serving as a donor together with another particle serving as an acceptor. There are also other special cases previously studied; however, there is no complete picture and unified understanding. Therefore, there is a strong need for a complete theory that models Forster-type NRET for the cases of mixed dimensionality including all combinations and configurations. We report a generalized theory for the Forster-type NRET, which includes the derivation of the effective dielectric function due to the donor in different confinement geometries and the derivation of transfer rates distance dependencies due to the acceptor in different confinement geometries, resulting in a complete picture and understanding of the mixed dimensionality.
Encyclopedia of substance abuse prevention, treatment, & recovery

Substance abuse is one of the most frequent and serious problems encountered by human service workers, criminal justice professionals, and clinicians. Unfortunately, many professionals in these fields receive little, if any, formal training about this problem. Our planned encyclopedia presents state-of-the-art research and evidence-based applications in A-to-Z format. Rather than create a compendium of specific drugs and drug effects, for which there are any number of fine titles already available, the focus will be upon practical knowledge and skills for pre-service and in-service human service professionals, including substance abuse counselors and prevention specialists.
Maternal deaths in the Lagos University Teaching Hospital: a ten-year review (1989 - 1998).

UNLABELLED To determine the causes and frequencies of maternal deaths in the Lagos University Teaching Hospital (LUTH) as seen at autopsy; to find their age associated frequencies; and to compare these findings with previous studies done in this hospital as well as those from other parts of the world. MATERIALS AND METHODS Those cases for which autopsies were requested and performed between January 1989 and December 1998 (inclusive) formed the material for this study. Excluded were patients who were dead on arrival, as well as badly autolysed cases. Records including autopsy protocols were retrieved from the Morbid Anatomy Department and relevant information was extracted and analysed from these records. RESULTS About 81% of autopsy certified were due to direct causes. The three leading causes of maternal death were obstetric haemorrhage (25.61% ), genital sepsis (19.68% ) and pregnancy-induced hypertension (16.71% ). The most common indirect cause of death was anaemia (7.01% ) making it the fifth leading cause of death in this study. Majority of deaths (70% ) occurred in those between 11 and 30 years. Maternal mortality Ratio was 2,920/100,000 live births. CONCLUSION Though maternal mortality figures from hospital-based studies are usually over-estimates of the true picture in the community they tend to provide a more thorough assessment of the underlying causes of death and their contributing factors, hence providing useful data for planning interventions.
MerTK is a novel therapeutic target in gastric cancer

Introduction The role of MerTK has not been assessed in gastric cancer (GC). The aim of this study was to identify a subgroup of GC patients with MerTK tumor overexpression, and to evaluate MerTK as a potential therapeutic target in this disease. Methods Protein and mRNA expression of MerTK were evaluated, and other various in vitro analyses including shRNA transfection, cell cycle anslysis, MTS assay and colony forming assay were carried out with GC cell lines and GC patient-derived cells (PDCs). Results shRNA-mediated knockdown of MerTK resulted in inhibition of cell growth, as well as increased cellular apoptosis in MerTK positive GC cells. Out of 192 GC patients, 16 (8.3%) patients showed strong protein expression and they had a significantly shorter overall survival compared to those with no MerTK expression. In 54 cases of GC PDCs, 4 cases (7.4%) showed mRNA overexpression, which was comparable to the protein expression rate. When we administered UNC1062, a novel MerTK-selective small molecular tyrosine kinase inhibitor, proliferation of MerTK overexpressing GC cells and PDCs were considerably inhibited. Conclusion MerTK may be involved in GC carcinogenesis, and it could be a potential novel therapeutic target in GC patients.
[Change in muscle strength in patients with anorexia nervosa during inpatient treatment--a pilot study].

OBJECTIVE Changes in muscular strength during treatment of inpatients suffering from anorexia nervosa were to be documented by exact measurement. METHODS The maximum strength of each side of the body was measured in 10 patients in the 1st, 2nd, 3rd, 4th, 6th, 8th and 10th weeks of inpatient treatment by means of a series of four different exercises. A well-established measurement technique, including the computer program "Quantitative Muscle Assessment", was used. All patients showed comparable symptoms of an anorexia nervosa, restricting type before admission (pure food restriction without over-exercising). RESULTS A polyphase course of the restitution of muscular strength could be seen in all patients. Since it is easily applied, the exercise "handigrip" has been used frequently elsewhere. In our study it failed to show a consistent development, in contrast to other muscle groups studied. Differences between the left and right sides could not be observed. CONCLUSIONS Patients with anorexia nervosa showed an objectively comparable inter-individual polyphase increase in the maximum strength of the muscles under investigation during weight restitution.
Basic Biological Sciences

Acidic proline-rich proteins were localized histologically by means of the indirect immunoperoxidase technique in the acinar cells of parotid and submandibular gland sections of both man and Macaca fascicularis. These proteins were also identified as constituents of the long term in vivoformed acquired pellicle on human tooth surfaces employing the same immunoperoxidase technique. Immunological quantitation of proline-rich proteins in whole and parotid saliva of 42 subjects indicates the presence of high concentrations in parotid secretions varying between 19-80 mg%, while their levels in whole saliva are significantly lower, ranging between 0-18 mg%. The concentrations of these proteins in whole saliva exhibited a negative correlation with plaque accumulation (r = -0.464) and gingival index scores (r = -0.576).
The Effect of Music Intervention on Dental Anxiety During Dental Extraction Procedure

Background: In order to minimize the possibility of unsuccessful dental extraction procedure due to dental anxiety, there are several approaches that can be used, including music intervention. Objective: The objective of this research was to investigate the effectiveness of classical and religious Islamic music on reducing dental anxiety. Materials and methods: Two hundred and twenty-five muslim participants (105 males, 120 females) were recruited for this study and randomly assigned to three groups: classical music group, religious Islamic music group, and the group with no music intervention, equally in numbers. Participant’s blood pressure (BP) and blood sample were taken prior to and after dental extraction to evaluate systolic and diastolic BP as well as nor-adrenaline plasma (NAP) level. All data were then analyzed by using t-test, ANOVA test, Mann-Whitney and Kruskawallis test. Results: There was a decrease in NAP level in the religious music group (0.110 ng/mL) and the control group (0.013 ng/mL) when initial NAP level was compared to post extraction NAP level, whilst the classical music group showed an increase of 0.053 ng/mL. There were significant differences found between the religious Islamic music group and the classical music group (p = 0.041) as well as the control group (p = 0.028) for the difference between pre and post NAP level, of which the NAP level of the religious Islamic group participants were lower. Conclusion: Religious Islamic music was proven to be effective in reducing dental anxiety in Muslim participants compared to classical music. Despite, further evaluation in a more heterogenous population with various religious and cultural background is needed.