Miracle-dz/UniFAR-FTUs huggingface dataset:
Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.

The cdc21+ gene of Schizosaccharomyces pombe was originally identified in a screen for cdc mutants affecting S phase and nuclear division. Here we show that the cdc21+ gene product belongs to a family of proteins implicated in DNA replication. These include the Saccharomyces cerevisiae MCM2 and MCM3 proteins, which are needed for the efficient function of certain replication origins, and S.cerevisiae CDC46, which is required for the initiation of chromosome replication. The cdc21 mutant is defective in the mitotic maintenance of some plasmids, like mcm2 and mcm3. The mutant arrests with a single nucleus containing two genome equivalents of DNA, and maintains a cytoplasmic microtubular configuration. Activation of most, but not all, replication origins in the mutant may result in failure to replicate a small proportion of the genome, and this could explain the arrest phenotypes. Using the polymerase chain reaction technique, we have identified new cdc21(+)-related genes in S.cerevisiae, S.pombe and Xenopus laevis. Our results suggest that individual members of the cdc21(+)-related family are highly conserved in evolution.
Kafka versus RabbitMQ: A comparative study of two industry reference publish/subscribe implementations: Industry Paper

Publish/subscribe is a distributed interaction paradigm well adapted to the deployment of scalable and loosely coupled systems. Apache Kafka and RabbitMQ are two popular open-source and commercially-supported pub/sub systems that have been around for almost a decade and have seen wide adoption. Given the popularity of these two systems and the fact that both are branded as pub/sub systems, two frequently asked questions in the relevant online forums are: how do they compare against each other and which one to use? In this paper, we frame the arguments in a holistic approach by establishing a common comparison framework based on the core functionalities of pub/sub systems. Using this framework, we then venture into a qualitative and quantitative (i.e. empirical) comparison of the common features of the two systems. Additionally, we also highlight the distinct features that each of these systems has. After enumerating a set of use cases that are best suited for RabbitMQ or Kafka, we try to guide the reader through a determination table to choose the best architecture given his/her particular set of requirements.
A chronicle of the banking and currency crises

The research undertaken in the area of banking and currency crises is surveyed. The causes and implications of the twin crises are discussed, along with the theoretical and empirical framework for investigating them. The overview has highlighted a number of interesting aspects. A consistent set of economic indicators is identified as being able to predict possible financial jitters. Non-quantified factors such as expectations, herding behaviour and contagion are also crucial beyond and above economic fundamentals. The direction of the twin crises’ causality is not clearly established yet. It is usually a banking crisis that precedes a currency downfall, with the latter creating a vicious spiral. Finally, a few other points are identified as issues of future concern.
Perinatal Care at the Threshold of Viability: An International Comparison of Practical Guidelines for the Treatment of Extremely Preterm Births

Over the last 2 decades, the survival rate of infants born at ≤25 weeks of gestation has increased; however, significant morbidity and disability persist. The commitment for their care gives rise to a variety of complex medical, social, and ethical aspects. Decision-making is a crucial issue that involves the infant, the family, health care providers, and society. In a review of the existing guidelines, we investigated the different approaches in the care of extremely preterm births in various countries. We found that many scientific societies and professional organizations have issued guidelines that address the recommendations for the care of these fetuses/neonates although to varying degrees. In this article we compare different approaches and assess the scientific grounds of the specific recommendations. With current standards, intensive care is generally considered justifiable at ≥25 weeks, compassionate care at ≤22 weeks, and an individual approach at 23 to 24 weeks, consistent with the parents' wishes and the infant's clinical conditions at birth.
Defective DNA‐mismatch repair: a potential mediator of leukemogenic susceptibility in therapy‐related myelodysplasia and leukemia

We investigated the potential role of defective DNA‐mismatch repair (MMR) as a mediator of leukemogenic susceptibility in patients with therapy‐related myelodysplasia (t‐MDS) and leukemia (t‐leuk). Thirty‐seven individuals with t‐MDS/t‐leuk were analyzed for microsatellite instability (MSI), the hallmark of defective DNA‐MMR. Using standardized international criteria, 5/37 (14%) patients displayed high MSI, whereas 3 other patients had low MSI (8%). To determine the stage at which MSI had developed, we analyzed the primary tumors of 12 patients. Three of 4 patients with high MSI t‐MDS/t‐leuk also had microsatellite unstable primary tumors. Conversely, MSI was not detected in any primary malignancy of patients with low MSI or microsatellite stable t‐MDS/t‐leuk (P = 0.0182). In the high MSI group, we further investigated genes targeted by defective DNA‐MMR (BAX, TGFBRII, IGFIIR, Caspase‐5, APC, PTEN, E2F4, MBD4, MSH6, and MSH3) in both primary tumor and t‐MDS/t‐leuk. However, no mutation was found in any gene. The significant association of MSI in t‐MDS/t‐leuk and corresponding primary tumors suggests that defective DNA‐MMR confers leukemogenic susceptibility to this cohort of patients. © 2002 Wiley‐Liss, Inc.
The Relationship Between The Real Exchange Rate and The Trade Balance: An Empirical Reassessment

This paper presents an empirical reassessment of the relationship between the real exchange rate and the trade balance, using the multivariate cointegration approach. Based on bilateral trade between the U. S. and the other G7 countries, we find evidence that the trade balance is unresponsive to the exchange rate in the very short run but is significantly affected by it within two years. We also find evidence supporting the empirical validity of the Marshall-Lerner condition, indicating that devaluations do improve the trade balance in the long run. [F32]
Some Perspectives from Rural School Districts on the No Child Left Behind Act.

While considerable policy research has spotlighted the impact of the No Child Left Behind Act (NCLB) on urban schools, less attention has been paid specifically to the experiences of rural schools and school districts as they implement the Act. This report by the Center on Education Policy (CEP), an independent nonprofit organization, examines the impact of NCLB on student achievement and teacher quality in some rural districts and the challenges those rural districts face in complying with the Act. It also analyzes differences in responses to NCLB between rural districts and urban or suburban districts (sometimes combined into a “non-rural” category).
Probabilistic Stability Analysis of Subsynchronous Resonance for Series-Compensated DFIG-Based Wind Farms

The wind speed of high uncertainty has an important impact on the emerging subsynchronous resonance (SSR) caused by the interaction between doubly-fed induction generator (DFIG)-based wind farms and series-compensated transmissions. This paper proposes a piecewise probabilistic collocation method (PPCM) for assessing the probabilistic stability of SSR in terms of the random wind speed. The PPCM can tackle the inherent nonlinearity resulting from the switching among different operational modes of DFIG. Using the proposed PPCM, the more accurate probability density function (PDF) of the damping can be obtained with a small computation burden. Furthermore, for the probabilistic stability assessment of SSR, this paper also develops the Weibull probabilistic model of the wind speed using the two-year statistical data. The results obtained with the proposed method show consistence with those of the Monte Carlo method (MCM). Finally, field data of SSR events in the practical wind farms are also presented to validate the effectiveness of the proposed method and its produced results.
SOE and Chinese Real Business Cycle

Chinese real business cycle (RBC) exhibits a unique pattern, which is characterized by moderate consumption volatility, substantially low investment volatility, and acyclical trade balance. These features are quite different from business cycles in other emerging markets and cannot be explained by existing emerging market RBC theories. Motivated by the facts that China undertook dramatic and persistent reform on state-owned enterprises (SOE) in the last 30 years, we construct a full-fledged general equilibrium model with SOE sector and show that the model does a fairly good job in accounting for the above features. The two main driving forces are: (1) shock to the share of downstream SOE in manufacturing sectors and (2) shock to upstream SOE's monopolistic position. These two shocks can explain 85 percent of output volatility, 79 percent of consumption volatility, 72 percent of investment volatility, and 57 percent of the volatility of trade balance-to-output ratio. Relatively speaking, standard shocks such as permanent productivity shock, credit shocks, country risk premium shocks, and preference shocks are less important in explaining Chinese economic fluctuations. Our results show that Chinese RBC may be affected substantially by domestic policies.
Tangential effects on magnetic vibrations and acoustic noise of induction machines using subdomain method and electromagnetic vibration synthesis

In the vibroacoustic analysis of electrical machines, the effect of the tangential magnetic force on the vibrations is generally neglected compared with the radial magnetic force, as well as the effect of the tangential flux density on the radial force, especially for induction machines. In this paper, these two assumptions are studied for the case of an induction machine at no-load and load states. First, time and space distribution of the magnetic flux density — including radial and tangential components — is computed in the air gap using a new semi-analytical subdomain modeling technique of squirrel-cage induction machine, including all harmonics. Then, magnetic forces are obtained by applying the Maxwell stress tensor. Stator vibrations are finally computed with and without neglecting the tangential effects using electromagnetic vibration synthesis implemented in MANATEE software. Results show that both tangential effects have a small impact on the maximum emitted noise in the case of the studied induction machine.
Theoretical calculation of relative intensity noise of multimode vertical-cavity surface-emitting lasers

An analytical calculation of relative intensity noise spectra of weakly index-guided vertical-cavity surface-emitting lasers (VCSELs) in a multimode regime is performed. We obtain analytical expressions that incorporate the spatial dependence of electrical field and carrier density profiles. Expressions are derived for single-mode and two-transverse-mode operation. Our analysis shows that single-mode noise spectrum depends on the spatial mode profile through a modal effective volume. Two-mode noise spectra also incorporate the dependence on the degree of spatial overlapping between the modes. Two resonance peaks appear in the noise spectra of the individual modes and total power of the two-mode VCSEL. We analytically show that those peaks appear at frequencies that correspond to the relaxation oscillation frequencies of the multimode laser. Simple analytical expressions are also derived for noise spectra at zero frequency.
The determinants of capital structure of Palestine‐listed companies

Purpose - The purpose of this paper is to examine the relationship between capital structure and debt lifetime among listed companies in Palestine stock market. Design/methodology/approach - This study investigates firms that have been listed on the Palestine securities exchange (PSE) over a five-year period (2000-2004). In total, 28 companies were listed in PSE since 1999. Only 15 firms working in different economic sectors qualified to be included in the study sample according to the availability and continuity of published financial statements during the period of 2000-2004. Variables used for the analysis include profitability, leverage ratios (total debt (TD), short-term debt (STD) and long-term debt (LTD)), liquidity (LQ), age, asset structure, and firm size and sales growth are also included as control variables. The panel character of the data allows for the use of panel data methodology. Panel data involves the pooling of observations on a cross-section of units over several times. Findings - The study has shown that the service companies have the highest TD ratio (53.69 percent), followed by industrial companies (50.86 percent), trade companies (34.11 percent) and agriculture companies (24.02 percent). The one way analysis of variance (ANOVA) shows no significant difference in the use of debt, neither total, LTD or STD among companies in the four sectors. Adding to that, ANOVA indicates insignificant differences among the companies in the sample with respect growth opportunities, size, age, tangibility (TAN), and LQ. The correlation analysis has shown that TD is positively and significantly related to TAN, on the country, no significant relationship between the long debt and STD on the one hand and age, growth, LQ, TAN, and size on the other hand. Originality/value - This paper is the first that employs a new database containing the market and accounting data (from 2000 to 2004). This study will contribute in examining the relationship between capital structure and debt lifetime among listed companies in the Palestine stock market.
Genome Sequence of Salt-Tolerant Bacillus safensis Strain VK, Isolated from Saline Desert Area of Gujarat, India

ABSTRACT Bacillus safensis strain VK was isolated from the rhizosphere of a cumin plant growing in the saline desert of Radhanpar, Gujarat, India. Here, we provide the 3.68-Mb draft genome sequence of B. safensis VK, which might provide information about the salt tolerance and genes encoding enzymes for the strain's plant growth-promoting potential.
RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection

Acute cellular rejection (ACR) is the adverse response of the recipient's immune system against the allogeneic graft. Using human surveillance endomyocardial biopsies (EMBs) manifesting ACR and murine allogeneic grafts, we profiled implicated microRNAs (miRs) and mRNAs. MiR profiling showed that miR‐21, ‐142‐3p, ‐142‐5p, ‐146a, ‐146b, ‐155, ‐222, ‐223, and ‐494 increased during ACR in humans and mice, whereas miR‐149‐5p decreased. mRNA profiling revealed 70 common differentially regulated transcripts, all involved in immune signaling and immune‐related diseases. Interestingly, 33 of 70 transcripts function downstream of IL‐6 and its transcription factor spleen focus forming virus proviral integration oncogene (SPI1), an established target of miR‐155, the most upregulated miR in human EMBs manifesting rejection. In a mouse model of cardiac transplantation, miR‐155 absence and pharmacological inhibition attenuated ACR, demonstrating the causal involvement and therapeutic potential of miRs. Finally, we corroborated our miR signature in acute cellular renal allograft rejection, suggesting a nonorgan specific signature of acute rejection. We concluded that miR and mRNA profiling in human and murine ACR revealed the shared significant dysregulation of immune genes. Inflammatory miRs, for example miR‐155, and transcripts, in particular those related to the IL‐6 pathway, are promising therapeutic targets to prevent acute allograft rejection.
Willingness to pay for publicly-financed health care: how should we use the numbers?

This paper addresses the question of how willingness to pay (WTP) values in health care evaluation can be used by policy makers. The way in which WTP values are used depends on from whom values are elicited and whether the good concerned is privately-financed or publicly-financed through taxation. Thus, four possible uses of WTP values are identified. The focus is on the two uses which arise in the publiclyfinanced situation. ‘Conventional’ use of WTP values, where the decision as to whether or not to provide a service depends upon whether or not WTP values are greater than total cost, applies only in the privately-financed, and not publiclyfinanced situations. The situations with publicly-financed goods are more complex. The use of WTP values for publicly-financed goods is justified and illustrated.
Urea modulation of β‐amyloid fibril growth: Experimental studies and kinetic models

Aggregation of β‐amyloid (Aβ) into fibrillar deposits is widely believed to initiate a cascade of adverse biological responses associated with Alzheimer's disease. Although it was once assumed that the mature fibril was the toxic form of Aβ, recent evidence supports the hypothesis that Aβ oligomers, intermediates in the fibrillogenic pathway, are the dominant toxic species. In this work we used urea to reduce the driving force for Aβ aggregation, in an effort to isolate stable intermediate species. The effect of urea on secondary structure, size distribution, aggregation kinetics, and aggregate morphology was examined. With increasing urea concentration, β‐sheet content and the fraction of aggregated peptide decreased, the average size of aggregates was reduced, and the morphology of aggregates changed from linear to a globular/linear mixture and then to globular. The data were analyzed using a previously published model of Aβ aggregation kinetics. The model and data were consistent with the hypothesis that the globular aggregates were intermediates in the amyloidogenesis pathway rather than alternatively aggregated species. Increasing the urea concentration from 0.4 M to 2 M decreased the rate of filament initiation the most; between 2 M and 4 M urea the largest change was in partitioning between the nonamyloid and amyloid pathways, and between 4 M and 6 M urea, the most significant change was a reduction in the rate of filament elongation.
Pension Reform, Factor Mobility and Trade with Country-Specific Goods

This paper studies the effects of pension reform in a two-country model with country-specific goods. It shows that in the case of dynamic efficiency, a switch from a pay-as-you-go to a more-funded pension scheme leads to an inflow of labour to the reforming country. Reallocation of capital depends on the degree of substitutability between goods produced in the countries. If the goods produced in the countries are substitutes (complements), capital stock grows (declines) in the reformed country relative to the neighbouring country. Social security reform makes goods produced in the reformed country cheaper; this has an additional negative effect on the old generation in the reformed country, but compensates the old generation in the neighbouring country with cheaper imports due to a reduction in the tax base arising from emigration.
Surplus deferred pension compensation for long-term K-12 employees: an empirical analysis for the Denver Public School Retirement System and four state plans

Abstract This study uses a unique data set of retiree characteristics and salary histories for administrators, teachers, and non-professional employees of the Denver Public School Retirement System (DPSRS) to analyze surplus deferred compensation for DPSRS and four state K-12 defined benefit pension plans. We find sizable levels of surplus deferred compensation for each plan, with significant differences across plans, job classes, and age groups. Across plans, differences in cost of living allowances impact the expected present value of retirement benefits more than benefit table differences when controlling for each respective factor. Somewhat surprisingly, the plans in our study with the largest present value of future benefits had lower employee contribution rates. Pension wealth for reduced benefits showed larger wealth accrual at younger ages than full, unreduced benefits, and younger cohorts starting work at an earlier age received significantly higher surplus deferred compensation.
There's No Place Like Home: The Influence of Home-State Going-Concern Reporting Rates on Going-Concern Opinion Propensity and Accuracy

SUMMARY: Prior research has had success identifying client financial characteristics that influence auditors' going-concern reporting decisions. In contrast, relatively little research has addressed whether auditors' circumstances and surroundings influence their propensities to issue modified opinions. We investigate whether auditors' decisions to issue GC opinions are affected by the rate of GC opinions being given in their proximate area. Controlling for factors that prior research associates with going-concern opinions and state-level economics, we find that non-Big 4 auditors located in states with relatively high first-time going-concern rates in the prior year are up to 6 percent more likely to issue first-time going-concern opinions. The results from our state-based GC measure casts doubt that this increased propensity is explained by economic factors and suggests that psychological factors may explain this behavior among auditors. Interestingly, this higher propensity increases auditors' Type I e.
Do We Need Computer Skills to Use a Computer? Evidence from Britain

Using data from the 1997 Skills Survey of the Employed British Workforce, we examine the returns to computer skills in Britain. Many researchers, using information on computer use, have concluded that wage differentials between computer users and non-users might, among others, be due to differences in the embodiment of computer skills. Using unique information on the importance, level of sophistication and effectiveness of computer use, we show that computer skills do not yield significant labour market returns for most types of use. Examining the returns to computer skills at different levels of sophistication of use, yields estimates suggesting returns to computer skills at the highest level of sophistication of use only.
Acute haematogenous osteomyelitis: An experimental model

A simple and reproducible model of acute haematogenous staphylococcal osteomyelitis is described. Twenty‐nine day‐old chickens were inoculated intravenously with 104–108 viable organisms Staphylococcus aureus per kg body weight and were killed 1–8 days after inoculation. Macroscopic septic foci could be detected within 24 hr of inoculation and were most commonly situated in the metaphyseal region of the proximal tibia and distal femur. Lesions in other organs were not observed. The production of osteomyelitis was dependent on the bacterial inoculum size. It was estimated that 5.5 × 105 viable organisms per kg body weight of chicken were required to produce osteomyelitis in 50 per cent of injected chickens. Chicken weights were monitored throughout the experiment. A close negative correlation existed between the logarithm of the bacterial inoculum size and the chicken growth rate in the first 24 hr following inoculation (r = −0.968, P< 0.01). The chicken growth rate was therefore used as an accurate predictor of osteomyelitis in individual chickens.