Miracle-dz/UniFAR-FTUs huggingface dataset:
Body fat has stronger associations with bone mass density than body mass index in metabolically healthy obesity

Objective The effect of obesity-induced metabolic abnormalities on bone mineral density (BMD) and osteoporosis are well established. However, the association between metabolically healthy obesity (MHO) and BMD remains unclear. Our aim was to investigate whether different obesity phenotypes in MHO were associated with BMD in a cross-sectional study. Methods All eligible adults receiving a health examination at the Tri-Service General Hospital from 2010 to 2016 were included. They were categorized based on body mass index (BMI) or percentage body fat (PBF). The associations between BMI or PBF and BMD were analyzed by adjusting for pertinent covariables. Results Males with normal weight and overweight and females with underweight and normal weight were associated with reduced BMD (β = 0.221, 95%CI = -0.354, -0.088; β = -0.155, 95%CI = -0.286, -0.023) (β = -0.736, 95%CI = -1.043, 0.429; β = -0.340, 95%CI = -0.567, -0.112), respectively. Females in Q1 had close to significant associations with reduced BMD (β = -0.253, 95%CI = -0.465, -0.041). Normal weight, overweight, Q2, and Q3 had stronger prediction of low BMD with ORs of 0.402 (95%CI = 0.204–0.791), 0.539 (95%CI = 0.321–0.905), 0.694 (95%CI = 0.490–0.982), and 0.466 (95%CI = 0.342–0.636), respectively. The relationship remained significant in male population that PBF was associated with reduced BMD with ORs of 0.435 (95%CI = 0.203, 0.935), 0.494 (95%CI = 0.247, 0.991), 0.268 (95%CI = 0.120, 0.597) in Q1, Q2, Q3 respectively. Conclusion Increased PBF had a significant association with low BMD in the MHO population. Obesity defined by PBF might be a useful indicator for low BMD. The association between body fat and bone health deserves further investigation regarding the potential pathophysiological mechanisms.
University of Birmingham Guidelines for biomarkers in autoimmune rheumatic diseases-evidence based analysis

Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation. In last years, despite many progresses in managing these patients, it has been shown that clinical remission is reached in less than 50% of patients and a personalised and tailored therapeutic approach is still lacking resulting in a significant gap between guidelines and real-world practice. In this context, the need for biomarkers facilitating early diagnosis and profiling those individuals at the highest risk for a poor outcome has become of crucial interest. A biomarker generally refers to a measured characteristic which may be used as an indicator of some biological state or condition. Three different types of medical biomarkers has been suggested: i. mechanistic markers; ii. clinical disease markers; iii. therapeutic markers. A combination of biomarkers from these different groups could be used for an ideal more accurate diagnosis and treatment. However, although a growing body of evidence is focused on improving biomarkers, a significant amount of this information is not integrated on standard clinical care. The overarching aim of this work was to clarify the meaning of specific biomarkers during autoimmune diseases; their possible role in confirming diagnosis, predicting outcome and suggesting specific treatments.
Dysphagia with fatal choking in oculopharyngeal muscular dystrophy

Rationale: Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant late-onset progressive muscle disorder typically characterized by ptosis, difficulty in swallowing, and proximal limb weakness. Underdiagnosis of OPMD is common in Asian countries and results in delayed diagnoses and fatal events. Patient concerns: Here, we report the case of a 53-year-old female who suffered from progressive dysphagia and experienced several choking events involving solid material. An extensive family history of dysphagia was noted, and 2 family members had died as a result of aspiration. Diagnoses: PABPN1 genotyping and DNA sequence analysis revealed a heterozygous (GCG)10(GCA)3GCG mutation that led to the diagnosis of OPMD. Interventions: Rehabilitation exercises, namely, the Shaker exercise and the Masako maneuver, were suggested. Outcomes: Improved swallowing ability with safe food intake was noted after 2 months of training. Surgical intervention will be considered when progression of the disease is noted. Lessons: Underdiagnosis and a lack of awareness of OPMD may lead to choking, aspiration pneumonia, and death in multiple members of affected families. Currently, there is no definitive treatment for OPMD, but rehabilitation exercises and surgical intervention are helpful in relieving dysphagia.
Laser-induced Single-bit Faults in Flash Memory: Instructions Corruption on a 32-bit Microcontroller

Physical attacks are a known threat posed against secure embedded systems. Notable among these is laser fault injection, which is often considered as the most effective fault injection technique. Indeed, laser fault injection provides a high spatial accuracy, which enables an attacker to induce bit-level faults. However, experience gained from attacking 8-bit targets might not be relevant on more advanced micro-architectures, and these attacks become increasingly challenging on 32-bit microcontrollers. In this article, we show that the flash memory area of a 32-bit microcontroller is sensitive to laser fault injection. These faults occur during the instruction fetch process, hence the stored value remains unaltered. After a thorough characterisation of the induced faults and the associated fault model, we provide detailed examples of bit-level corruption of instructions and demonstrate practical applications in compromising the security of real-life codes. Based on these experimental results, we formulate a hypothesis about the underlying micro-architectural features that explain the observed fault model.
A Modified Extended Kalman Filter for a Two-Antenna GPS/INS Vehicular Navigation System

Recently, the integration of an inertial navigation system (INS) and the Global Positioning System (GPS) with a two-antenna GPS receiver has been suggested to improve the stability and accuracy in harsh environments. As is well known, the statistics of state process noise and measurement noise are critical factors to avoid numerical problems and obtain stable and accurate estimates. In this paper, a modified extended Kalman filter (EKF) is proposed by properly adapting the statistics of state process and observation noises through the innovation-based adaptive estimation (IAE) method. The impact of innovation perturbation produced by measurement outliers is found to account for positive feedback and numerical issues. Measurement noise covariance is updated based on a remodification algorithm according to measurement reliability specifications. An experimental field test was performed to demonstrate the robustness of the proposed state estimation method against dynamic model errors and measurement outliers.
Non-homologous recombination between Alu and LINE-1 repeats results in a 91 kb deletion in MERTK causing severe retinitis pigmentosa

Purpose Retinitis pigmentosa (RP) represents a large group of inherited retinal diseases characterized by clinical and genetic heterogeneity. Among patients with RP in northern Sweden, we identified two severely affected siblings and aimed to reveal a genetic cause underlying their disease. Methods Whole exome sequencing (WES) was performed on both affected individuals. Sequence variants were filtered using a custom pipeline to find a rare or novel variant predicted to affect protein function. Genome-wide genotyping was used to identify copy number variants (CNVs) and homozygous regions with potential disease causative genes. Results WES uncovered a novel heterozygous variant in the MER proto-oncogene, tyrosine kinase (MERTK) gene, c.2309A>G, p.Glu770Gly located in the tyrosine kinase domain and predicted to be likely pathogenic. The second variant, a large heterozygous deletion encompassing exons 1 to 7 of the MERTK gene, was revealed with genome-wide genotyping. The CNV analysis suggested breakpoints of the deletion, in the 5′-untranslated region and in intron 7. We identified genomic sequences at the site of the deletion as part of L1ME4b (LINE/L1) and AluSx3 that indicated a non-homologous recombination as a mechanism of the deletion evolvement. Conclusions Patients with RP in this study were carriers of two novel allelic mutations in the MERTK gene, a missense variant in exon 17 and an approximate 91 kb genomic deletion. Mapping of the deletion breakpoints allowed molecular testing of a cohort of patients with RP with allele-specific PCR. These findings provide additional information about mutations in MERTK for molecular testing of unsolved recessive RP cases and highlight the necessity for analysis of large genomic deletions.
Sexual dimorphism in the Arachnid orders

Sexual differences in size and shape are common across the animal kingdom. The study of sexual dimorphism (SD) can provide insight into the sexual- and natural-selection pressures experienced by males and females in different species. Arachnids are diverse, comprising over 100,000 species, and exhibit some of the more extreme forms of SD in the animal kingdom, with the males and females of some species differing dramatically in body shape and/or size. Despite this, research on arachnid SD has primarily focused on specific clades as opposed to observing traits across arachnid orders, the smallest of which have received comparatively little attention. This review provides an overview of the research to date on the trends and potential evolutionary drivers for SD and sexual size dimorphism (SSD) in individual arachnid orders, and across arachnids as a whole. The most common trends across Arachnida are female-biased SSD in total body size, male-biased SSD in relative leg length and SD in pedipalp length and shape. However, the evolution of sexually dimorphic traits within the group is difficult to elucidate due to uncertainty in arachnid phylogenetic relationships. Based on the dataset we have gathered here, we highlight gaps in our current understanding and suggest areas for future research.
The tick sign – a new and simple test to diagnose keratoconus at the slit lamp

containing Kenalog Orifarm were observed to have a grainy appearance with agglomerates, which did not dissolve after shaking. As a consequence of our observation and the analysis performed by DKMA, we have stopped using Kenalog Orifarm and have subsequently given more than 300 periocular injections in our department without complication using the original product from BristolMyers Squibb Company (Kenalog BMS). We speculate that the four cases of persistent diplopia resulted from steroid accumulation in the proximity of the inferior rectus muscle in insoluble agglomerates in the Kenalog Orifarm. Due to the particle size, diffusion to the nearby tissue may have been impaired leaving a high toxic concentration of steroid near the muscle, ultimately causing muscle atrophy, impaired function of the inferior rectus muscle and diplopia. This is in accordance with observation done by Rodger (1965) and Raab (1974). Rodger et al. injected methylprednisolone acetate 40 mg/ml into the belly of a rectus muscle during a bilateral resection; one muscle was resected, whereas the other was resected 2 weeks later and submitted for histological examination. Microscopic examination revealed a 100 micron long nonstainable spicule embedded in the muscle fragment. A mild infiltration of inflammatory cells was present in the immediate area (Rodger 1965). Raab has described a case with hyperand esotropia after an injection of methylprednisolone acetate 40 mg/ml near the upper fornix in one eye. During strabismus surgery 7 months later, the superior rectus muscle was found to be moderately thin and atrophic whereas the inferior rectus muscle appeared normal (Raab 1974). These two observations support our hypothesis that the steroid formulation (Kenalog Orifarm) used in the four cases with persisting diplopia may have caused damage to the inferior rectus muscle. In conclusion, great care must be taken when administering periocular steroid injections with ‘off label’ products. Original, parallel imported and generic products may differ with respect to adjuvants and preservative, which may influence pharmacokinetics effect of the drugs and side-effects. References
Investigation of factors affecting postpartum maternal weight retention: A cross-sectional study.

OBJECTIVE To examine weight retention and affecting factors among 12-18 months postpartum women. METHODS The descriptive cross-sectional study was conducted from January 1 to June 30, 2012 at Gazikent 3rd Primary Health Care Centre, Izmir, Turkey, and comprised pregnant women registered with the centre in their 12-18 months postpartum phase. Data was collected using Mother Introduction Form and International Physical Activity Questionnaire-Short Form. SPSS 15 was used for data analysis. RESULTS There were 239 women with a mean age of 30.81±4.59 years. Of the total, 182(76.2%) subjects had weight retention; 106(44.4%) having 0.5-5kg, and 49(20.6%) with 5.5-10 kg. Overall mean weight retention rate was 4.09±4.90kg (range: -9-27kg). Weight retention had significant correlations with chronic illness (p=0.037), having been educated about physical exercise during pregnancy (p=0.001), skipping meals (p=0.036), average pre-pregnancy weights (p=0.019), average pre-pregnancy body mass index (p=0.049), average weight gained during pregnancy (p=0.009), achieving weight gain during pregnancy as recommended by the Institute of Medicine guidelines (p=0.002), and mean physical activity score (p=0.006). CONCLUSIONS Women should be monitored for their body mass index and weight in the postpartum period and during pregnancy.
On aggregation in ranking median regression

In the present era of personalized customer services and recommender systems, predicting the preferences of an individual over a set of items indexed by (cid:74) n (cid:75) = { 1 , . , n } , n ≥ 1, based on its characteristics, modelled as a r.v. X say, is an ubiquitous issue. Though easy to state, this predictive problem referered to as ranking median regression (RMR in short) is very diﬃcult to solve in practice. The major challenge lies in the fact that, here, the (discrete) output space is the symmetric group S n , composed of all permutations of (cid:74) n (cid:75) , of explosive cardinality n ! , and which is not a subset of a vector space. It is thus far from straightforward to build (non parametric) predictive rules taking their values in S n , except by means of ranking aggregation techniques implemented at a local level, as proposed in [1] or [2]. However, such local learning techniques exhibit high instability and it is the main goal of this paper to investigate to which extent Kemeny ranking aggregation of randomized RMR rules may remedy this drawback. Beyond a theoretical analysis establishing its validity, the relevance of this novel ensemble learning technique is supported by experimental results.
iLamps: geometrically aware and self-configuring projectors

Projectors are currently undergoing a transformation as they evolve from static output devices to portable, environment-aware, communicating systems. An enhanced projector can determine and respond to the geometry of the display surface, and can be used in an ad-hoc cluster to create a self-configuring display. Information display is such a prevailing part of everyday life that new and more flexible ways to present data are likely to have significant impact. This paper examines geometrical issues for enhanced projectors, relating to customized projection for different shapes of display surface, object augmentation, and co-operation between multiple units.We introduce a new technique for adaptive projection on nonplanar surfaces using conformal texture mapping. We describe object augmentation with a hand-held projector, including interaction techniques. We describe the concept of a display created by an ad-hoc cluster of heterogeneous enhanced projectors, with a new global alignment scheme, and new parametric image transfer methods for quadric surfaces, to make a seamless projection. The work is illustrated by several prototypes and applications.
Out of Site

GrabYourWallet, #boycottNRA and other online boycott campaigns have attracted substantial public interest in recent months. However, a number of significant challenges are preventing online boycotts from reaching their potential. In particular, complex webs of brands and subsidiaries can make it difficult for participants to conform to the goals of a boycott. Similarly, participants and organizers have limited visibility into a boycott's progress. This affects their ability to use sociotechnical innovations from social computing to incentivize participation. To address these challenges, this paper makes a system contribution: a new boycott tool called Out of Site. Out of Site uses lightweight automation to remove obstacles to successful online boycotts. We describe the design challenges associated with Out of Site and report results from two phases of deployment with the GrabYourWallet and Stop Animal Testing boycott communities. Our findings highlight the potential of boycott-assisting technologies and inform the design of this new class of technologies. Finally, like is the case for many systems in social computing, while we designed Out of Site for pro-social uses, there are a number of easily predictable ways in which the system can be leveraged for anti-social purposes (e.g. exacerbating filter bubble issues, empowering boycotts of businesses owned by racial, ethnic, and religious minorities). As such, we developed for this project a new, very straightforward design approach that treats preventing these anti-social uses as a top-tier design concern. This approach stands in contrast to the status quo of ignoring potential anti-social uses and/or considering them to be a secondary design priority. We discuss how our simple approach may help other research projects reduce their potential negative impacts with minimal burden.
Bottom-up processing of curvilinear visual features is sufficient for animate/inanimate object categorization

Animate and inanimate objects differ in their intermediate visual features. For instance, animate objects tend to be more curvilinear compared to inanimate objects (e.g., Levin, Takarae, Miner, & Keil, 2001). Recently, it has been demonstrated that these differences in the intermediate visual features of animate and inanimate objects are sufficient for categorization: Human participants viewing synthesized images of animate and inanimate objects that differ largely in the amount of these visual features classify objects as animate/inanimate significantly above chance (Long, Stormer, & Alvarez, 2017). A remaining question, however, is whether the observed categorization is a consequence of top-down cognitive strategies (e.g., rectangular shapes are less likely to be animals) or a consequence of bottom-up processing of their intermediate visual features, per se, in the absence of top-down cognitive strategies. To address this issue, we repeated the classification experiment of Long et al. (2017) but, unlike Long et al. (2017), matched the synthesized images, on average, in the amount of image-based and perceived curvilinear and rectilinear information. Additionally, in our synthesized images, global shape information was not preserved, and the images appeared as texture patterns. These changes prevented participants from using top-down cognitive strategies to perform the task. During the experiment, participants were presented with these synthesized, texture-like animate and inanimate images and, on each trial, were required to classify them as either animate or inanimate with no feedback given. Participants were told that these synthesized images depicted abstract art patterns. We found that participants still classified the synthesized stimuli significantly above chance even though they were unaware of their classification performance. For both object categories, participants depended more on the curvilinear and less on the rectilinear, image-based information present in the stimuli for classification. Surprisingly, the stimuli most consistently classified as animate were the most dangerous animals in our sample of images. We conclude that bottom-up processing of intermediate features present in the visual input is sufficient for animate/inanimate object categorization and that these features may convey information associated with the affective content of the visual stimuli.
Seasonal dynamics and changing sea level as determinants of the community and trophic structure of oribatid mites in a salt marsh of the Wadden Sea

Global change processes affect seasonal dynamics of salt marshes and thereby their plant and animal communities. However, these changes have been little investigated for microarthropod communities. We studied the effect of seasonality and changes in sea level on oribatid mites in the natural salt marsh and on artificial islands in the back-barrier environment of the island Spiekeroog (Wadden Sea, Germany). Three zones of the artificial islands were filled with transplanted sods from the lower salt marsh zone and thereby exposed to three different inundation frequencies. We hypothesized that oribatid mite communities will differ along the natural salt marsh vegetation zones [upper salt marsh (USM), lower salt marsh (LSM), pioneer zone (PZ)], which are influenced by different tidal regimes. Accordingly, total oribatid mite densities declined from the USM and LSM to the PZ. Similarly, oribatid mite species compositions changed along the salt marsh transect and also responded to variations in inundation frequency in LSM on artificial islands with typical species of the USM, LSM and PZ being Multioppia neglecta (USM), Hermannia pulchella (LSM), Zachvatkinibates quadrivertex (LSM, PZ) and Ameronothrus schneideri (LSM, PZ). Oribatid mite density in the salt marsh and on the artificial islands was at a maximum in winter and spring; this was due in part to high density of juveniles, pointing to two reproductive periods. We hypothesized that oribatid mite trophic structure changes due to variations in abiotic (e.g., tidal dynamics, temperature) and biotic conditions (e.g., resource availability). Stable isotope (15N, 13C) and neutral lipid fatty acid analyses indicated that oribatid mite species have different diets with e.g., Z. quadrivertex feeding on macroalgae and fungi, A. schneideri feeding on microalgae and bacteria, and Scheloribates laevigatus and M. neglecta feeding on dead organic matter, bacteria and fungi. Overall, the results indicate that oribatid mite species in salt marshes are affected by changes in environmental factors such as inundation intensity, with the effects being most pronounced in species with narrow trophic niches and limited niche plasticity. The results also indicate that oribatid mite communities of the LSM respond little to short-term (one year) changes in inundation frequency.