Miracle-dz/UniFAR-FTUs huggingface dataset:
MicroRNA-146a inhibits NF-κB activation and pro-inflammatory cytokine production by regulating IRAK1 expression in THP-1 cells

MicroRNA (miR)-146a levels are reduced in peripheral blood mononuclear cells of patients with systemic lupus erythematosus (SLE); however, its function is not well understood. The present study investigated the role of miR-146a in the regulation of lipopolysaccharide (LPS)-induced inflammation in THP-1 cells. A miR-146a mimic and an inhibitor were used to overexpress and downregulate miR-146a expression, respectively. Reverse transcription-quantitative PCR and western blot analyses were performed to evaluate interleukin (IL)-1 receptor-associated kinase 1 (IRAK1) expression, and western blot analysis was applied to assess nuclear factor-κB activation by analyzing p65 subunit levels in the nucleus. To investigate the effects of miR-146a on LPS-induced inflammation, IL-6 and tumor necrosis factor-α (TNF-α) levels were also measured using ELISA. The results of the present study revealed thatmiR-146a overexpression significantly reduced IRAK1 expression, reduced p65 levels in the nucleus and reduced IL-6 and TNF-α levels in the supernatant of the cell culture medium of THP-1 cells following LPS treatment. Luciferase assays confirmed IRAK1 to be a direct target of miR-146a in THP-1 cells. In conclusion, miR-146a may regulate IRAK1 expression and inhibit the activation of inflammatory signals and secretion of pro-inflammatory cytokines. The present study revealed, at least in part, the mechanisms by which miR-146a regulate the inflammatory response in SLE.
Psychosocial Impact of Irritable Bowel Syndrome Among Teachers in Tabuk, Saudi Arabia

In the present study, we aimed to study the psychosocial impact of irritable bowel syndrome among Saudi teachers in Tabuk. Across-sectional descriptive study was conducted among 362 teachers randomly selected from a total number of 60 schools in Tabuk City during the period January 2015 to June 2015. Participants were invited to sign a written informed consent, then responded t a structured questionnaire to collect socio-demographic factors, absence from work or sick leave due to IBS symptoms, partner employment, house type (own vs. rent), income, income adequacy, participation in care of children, continuous stress, excessive, and sleeping hours. Irritable bowel syndrome patients were more likely to be absent from work, took sick leave, and had more stress than those without the syndrome P-value 0.05. Irritable bowel syndrome patients were more prone to stress, absent from work, and took more sick leave than those without the syndrome. Screening for and the earlier detection of workers with irritable bowel syndrome could alleviate stress save working hours.
The Continuing Story of SN IIb 2013df: New Optical and IR Observations and Analysis

This work has been supported by the Hungarian Scientific Research Fund (OTKA) Grants NN107637, K104607, K83790, and K113117. TS is supported by the OTKA Postdoctoral Fellowship PD112325. JCW’s Supernova group at the UT Austin is supported by NSF Grant AST 11-09881 grant. JMS is supported by an NSF Astronomy and Astrophysics Postdoctoral Fellowship under award AST-1302771. KS and AP are supported by the ‘Lend¨ulet-2009’ Young Researchers Program and the LP2012-31 grant of the Hungarian Academy of Sciences, respectively; KS is also supported by the ESA PECS Contract no. 4000110889/14/NL/NDe.
POSTHARVEST QUALITY OF FEIJOA FLOWERS TREATED WITH DIFFERENT PRESERVATIVE SOLUTIONS AND 1-METHYLCYCLOPROPENE

O objetivo deste trabalho foi avaliar a manutencao da qualidade pos-colheita de flores de goiabeira-serrana (Acca sellowiana Berg), em resposta ao tratamentocom solucoes conservantes e 1-metilciclopropeno (1-MCP). As flores recem-abertas de goiabeira-serrana foram colhidas no inicio da manha (entre 8 e 10 h) e submetidas a “pulsing” com solucoes conservantes de acido salicilico, acido ascorbico e sacarose, todas nas doses de 0 (testemunha), 2, 5 e 10%, e aplicacao de 1-MCP nas doses de 0 (testemunha), 250; 500 e 1.000 nL L-1. Cada ensaio com solucao conservante ou de tratamento com 1-MCP consistiu em experimento distinto, segundo delineamento experimental inteiramente casualizado, com quatro repeticoes, cada repeticao com quatro flores. Apos o tratamento, as flores foram armazenadas durante 12 dias a 10±1 oC e 85±5% UR, e as petalas avaliadas visualmente, em intervalos de dois dias, quanto a murcha e escurecimento, em uma escala de 1 (pouco acentuado) a 5 (muito acentuado), e de cor, numa escala de 1 (rosa intenso) a 5 (branco). O 1-MCP na dose de 500 nL L-1 e o acido salicilico, independentemente da dose, prolongaram a manutencao da cor das petalas por oito e seis dias de armazenamento, respectivamente. A murcha das petalas tambem foi menor nos tratamentos com acido salicilico, 1-MCP ou acido ascorbico; flores tratadas com acido salicilico passaram para 2 na escala evolutiva, no sexto dia nas doses de 5 e 10%, e no oitavo dia na dose de 2%; enquanto em flores tratadas com 1-MCP nas doses de 500 e 1.000 nL L-1 e acido ascorbico nas doses de 2 e 5%, isto ocorreu no quarto dia de armazenamento. O maior retardo no escurecimento das petalas (ate o quarto dia de armazenamento) foi obtido com 500 nL L-1 de 1-MCP.
Evaluation of a Rehabilitation System for the Elderly in a Day Care Center

This paper presents a rehabilitation system based on a customizable exergame protocol to prevent falls in the elderly population. The system is based on depth sensors and exergames. The experiments carried out with several seniors, in a day care center, make it possible to evaluate the usability and the efficiency of the system. The outcomes highlight the user-friendliness, the very good usability of the developed system and the significant enhancement of the elderly in maintaining a physical activity. The performance of the postural response is improved by an average of 80%.
The very faint hard state of the persistent neutron star X-ray binary SLX 1737-282 near the Galactic Centre

We report on a detailed study of the spectral and temporal properties of the neutron star low mass X-ray binary SLX 1737-282, which is located only ~1degr away from Sgr A. The system is expected to have a short orbital period, even within the ultra-compact regime, given its persistent nature at low X-ray luminosities and the long duration thermonuclear burst that it has displayed. We have analysed a Suzaku (18 ks) observation and an XMM-Newton (39 ks) observation taken 7 years apart. We infer (0.5-10 keV) X-ray luminosities in the range 3-6 x10^35erg s-1, in agreement with previous findings. The spectra are well described by a relatively cool (kTbb = 0.5 keV) black body component plus a Comptonized emission component with {\Gamma} ~1.5-1.7. These values are consistent with the source being in a faint hard state, as confirmed by the ~ 20 per cent fractional root mean square amplitude of the fast variability (0.1 - 7 Hz) inferred from the XMM-Newton data. The electron temperature of the corona is >7 keV for the Suzaku observation, but it is measured to be as low as ~2 keV in the XMM-Newton data at higher flux. The latter is significantly lower than expected for systems in the hard state. We searched for X-ray pulsations and imposed an upper limit to their semi-amplitude of 2 per cent (0.001 - 7 Hz). Finally, we investigated the origin of the low frequency variability emission present in the XMM-Newton data and ruled out an absorption dip origin. This constraint the orbital inclination of the system to 65 degr unless the orbital period is longer than 11 hr (i.e. the length of the XMM-Newton observation).
HUBUNGAN DUKUNGAN KELUARGA DENGAN KEPATUHAN DIET PASIEN HIPERTENSI DI PUSKESMAS PAYUNG SEKAKI PEKANBARU TAHUN 2017

Latar Belakang : Salah satu masalah kesehatan yang sangat serius saat ini adalah hipertensi yang disebut sebagai the silent killer. Peningkatan tekanan darah yang berlangsung dalam jangka waktu lama (persisten) dapat menimbulkan kerusakan pada ginjal (gagal ginjal), jantung (penyakit jantung koroner), dan otak (menyebabkan stroke) bila tidak dideteksi secara dini dan mendapat pengobatan yang memadai, maka akan menyebabkan kematian. Kepatuhan menjalankan diet merupakan salah satu cara untuk menurunkan hipertensi sehingga dapat mengatasi dan mencegah hipertensi dan komplikasinya. Tujuan : penelitian ini bertujuan untuk mengetahui adakah hubungan antara dukungan keluarga dengan kepatuhan diet pasien hipertensi di Puskesmas Payung Sekaki Pekanbaru. Metode : Metode penelitian ini adalah jenis kuantitatif dengan pendekatan studi kolerasi. Populasinya yaitu seluruh pasien hipertensi yang berkunjung di puskesmas payung sekaki Pekanbaru sebanyak 102 orang dengan jumlah sampel dari sebanyak 81 orang. Teknik pengambilan sampel yang digunakan adalah accydental sampling. Hasil : Berdasarkan hasil uji statistik dengan chi squaretest, maka diperoleh nilai p-value adalah 0,002 (p<0,05), yang berarti bahwa ada hubungan dukungan keluarga terhadap kepatuhan diet pasien hipertensi di Puskesmas Payung Sekaki Pekanbaru Tahun 2017. Kesimpulan : pasien yang mendapatkan dukungan dengan baik dari keluarganya cenderung lebih mudah patuh dalam melakukan diet hipertensinya.
Nivolumab — perspectives in cancer treatment

Blockade of the immune checkpoint PD-1 is a new and promising strategy for the treatment of advanced cancers. The introduction of nivolumab has improved prognosis in a large group of cancer patients. Currently, it is possible to obtain results of treatment that have not previously been observed in cancer immunotherapy. It seems that nivolumab has less treatment toxicity than many conventional chemo-therapeutics or ipilimumab. Nivolumab is currently registered in oncology patients with advanced melanoma, kidney cancer, and non-small cell lung cancer. In the near future the scope of registration of the drug will probably expand to other indications in malignant tumours. More details on the activity of the drug used in a variety of schemes and various types of cancer, as well as predictive factors of therapy, will be available after the announcement of further results of ongoing numerous clinical studies using nivolumab.
Asymmetric Attention and Stock Returns

This paper constructs a new measure of attention allocation by local investors relative to nonlocals using aggregate search volume from Google. We first present a conceptual framework in which local investors optimally choose to focus their attention on local stocks when they receive private news, leading to an asymmetric allocation of attention between local and nonlocal investors. Consistent with the main prediction of this framework, we find that firms attracting abnormally high asymmetric attention from local relative to nonlocal investors earn higher returns. A portfolio that goes long in stocks with high asymmetric attention and short in stocks with low asymmetric attention has an alpha of 32 basis points per month. The results are stronger for stocks with a greater degree of information friction. The new measure of asymmetric attention allows one to infer the arrival of unobservable private information by observing investors’ attention allocation behavior. This paper was accepted by Karl Diether, finance.
Network Neutrality under ISP duopoly: on the ability to assign capacity

We analyze the impact of network neutrality regulation on: (i) competition between CPs, and on (ii) ISPs. incentives to invest. We consider both competition between ISPs and between CPs and show that, if ISPs can o¤er network services of different quality to CPs, they prefer to sell the highest quality network services to the CP that collects the highest advertising revenues. We further show that the impact of network neutrality regulation on the investment in the quality of network services is potentially ambiguous and depends on: (i) whether ISPs are symmetric, and (ii) the ISPs.ability to assign network.s capacity to CPs. If ISPs are symmetric and have full discretion on how to allocate the level of quality of network services among CPs, investment and welfare are higher under the discriminatory regime.
Lysophosphatidic Acid UpRegulates Expression of Interleukin-8 and-6 in Granulosa-Lutein Cells through Its Receptors and Nuclear Factor-B Dependent Pathways : Implications for Angiogenesis of Corpus Luteum and Ovarian Hyperstimulation Syndrome

Context: Lysophosphatidic acid (LPA) was found at significant amounts in follicular fluid of preovulatory follicle. The lysophospholipase D activity of serum from women receiving ovarian stimulation was higher than women with natural cycles. Angiogenic cytokines, including IL-6, IL-8, and vascular endothelial growth factor, increased in plasma and ascites of patients with ovarian hyperstimulation syndrome. The role of LPA in ovarian follicles is unclear.
Self-care actions in patients with heart failure

Corresponding author Heloisa Ribeiro do Nascimento Doutor Enéas de Carvalho Aguiar Avenue, 419, São Paulo, SP, Brazil. Zip Code: 05403-000 helorn@usp.br Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brazil. Conflicts of interest: there are no conflicts of interest to declare. Abstract Objective: Identify self-care actions of patients with heart failure in two settings: the emergency and outpatient care units, and to identify the main precipitating factors of heart decompensation. Methods: Cross-sectional study including 120 patients with heart failure in two settings, emergency and outpatient care units. Three validated instruments were used. Results: There was no statistically significant difference between the self-care groups, with low scores on weight control, vaccination and communication. Most of the study population was elderly, retired, with Chagas disease, and patients from the emergency care unit had the worst levels of urea, creatinine and hemoglobin. Conclusion: The patients practice self-care when they perceive aggravation in their clinical conditions and communication, weight control and vaccination, with no difference between the groups. Heart failure in emergency room patients may be associated with sociodemographic factors and characteristics of severity, including hemodynamic profile related to prolonged hospitalization and high mortality.
SPECIAL ISSUES IN BREAST CANCER REGIONAL ANALGESIA AND BREAST CANCER SURGERY

Breast cancer is the most common major malignancy in women worldwide and the second leading cause of cancer death [1]. Patients undergoing breast surgery are normally associated with a high incidence of postoperative nausea and vomiting (PONV), pain and painful restricted movement. The incidence of PONV during the 24-hour interval after breast cancer surgery has been reported around 59% [2]. PONV is greater in patients undergoing general anesthesia, in female patients, in patients experiencing postoperative pain, and in women undergoing breast surgery. Troublesome pain and PONV can prolong recovery and hospitalization, and are some of the most common causes of hospital admission following ambulatory surgery [3]. Postoperative pain continues to be under-treated and it is known that bad pain relief may contribute to a high risque of developing a chronic pain in the operative site [4]. Patient-controlled intravenous analgesia with opioids remains a common strategy for management of postoperative pain; however, this method is far from ideal because efficacy is suboptimal and side effects frequent [5]. Opioids produce adverse effects such as nausea, vomiting and sedation so alternative analgesic regimes in the perioperative period may reduce unwanted side effects. Regional anesthetic techniques, such as thoracic epidural analgesia, offer better quality analgesia than systemic opioids in major abdominal and thoracic surgery [6]. Local and regional techniques, including local anesthetic infiltration has indisputable benefits in postoperative pain relief in many clinical settings, however, its efficacy in patients undergoing breast surgery remains controversial [7-9]. Regional anesthesia using paravertebral block (PVB) is a good alternative to general anesthesia for breast cancer surgery. PVB provides superior analgesia and fewer side effects related to a standard opiate-based postoperative analgesia [10-16]. It has been used as the sole anesthetic [10, 14, 16] and for ambulatory breast surgery [12]. In the course of the development of systemic analgesics and epidural anesthesia, PVB has fallen into disfavor. Numerous reports attest the safety and efficacy of PVB to provide better postoperative analgesia and its ability to shorten hospitalization after breast surgery compared to general anesthesia [10-14]. Here, we briefly review some of the background to this technique and some interesting new developments that provide additional reasons why this block should be considered as part of the anesthetic for breast surgery [15-16].
The landscape of mental health services in rural Canada

Many Canadians living in rural and remote communities face difficulty accessing mental health services. This has become a pressing issue in the Canadian healthcare system due to an increased focus on mental health and the high rate of suicide in rural regions as compared to urban communities. The inaccessibility of mental health services in rural Canada can only be partially explained by the lack of psychiatrists working in these areas. Additional access barriers arise from sociocultural nuances within individual rural communities, including an increased value placed on self-reliance and stigmatization of seeking mental health support. It has been challenging for mental health services to adequately address the vast social, economic and cultural differences that exist among individual rural communities – a reality that necessitates holistic mental health programs tailored to the unique complexities of each community. Nonetheless, programs aiming to improve accessibility of rural mental health services do exist across Canada, often employing technology to deliver psychiatric support to rural patients or provide guidance to rural primary care physicians who care for patients with mental illness. This narrative review outlines the barriers that are impeding mental health care in rural Canada, the existing strategies to circumvent these barriers, and the role of current medical students in the future of rural psychiatry.
Cumulus Microphysics and Climate Sensitivity

Precipitation processes in convective storms are potentially a major regulator of cloud feedback. An unresolved issue is how the partitioning of convective condensate between precipitation-size particles that fall out of updrafts and smaller particles that are detrained to form anvil clouds will change as the climate warms. Tropical Rainfall Measuring Mission (TRMM) observations of tropical oceanic convective storms indicate higher precipitation efficiency at warmer sea surface temperature (SST) but also suggest that cumulus anvil sizes, albedos, and ice water paths become insensitive to warming at high temperatures. International Satellite Cloud Climatology Project (ISCCP) data show that instantaneous cirrus and deep convective cloud fractions are positively correlated and increase with SST except at the highest temperatures, but are sensitive to variations in large-scale vertical velocity. A simple conceptual model based on a Marshall–Palmer drop size distribution, empirical terminal velocity–particle size relationships, and assumed cumulus updraft speeds reproduces the observed tendency for detrained condensate to approach a limiting value at high SST. These results suggest that the climatic behavior of observed tropical convective clouds is intermediate between the extremes required to support the thermostat and adaptive iris hypotheses.
New insights into the curing of epoxidized linseed oil with dicarboxylic acids

The effect of systematically increasing chain length of a series of linear α,ω-dicarboxylic acids (DCAs) from C6 to C18 diacids and a cyclic diacid, Pripol 1009F, on thermal and mechanical properties of the resultant epoxy thermosets derived from epoxidized linseed oil (ELO) are reported. Different techniques including differential scanning calorimetry (DSC), solvent extraction, FT-IR, NMR, dynamic mechanical analysis (DMA), tensile tests and thermogravimetric analysis (TGA) are used in this study. The results indicated that the obtained epoxy resins were highly crosslinked polymers with only a small fraction of low molecular weight soluble materials. The glass transition temperature (Tg), tensile strength, Young's modulus, elongation at break and toughness decreased while the thermal stability increased with respect to increasing chain length of DCAs. Interestingly, strain hardening was only observed for adipic acid (C6) sample for which the best mechanical properties observed.
Identifying climate services needs for national planning: insights from Malawi

The importance of climate services, i.e. providing targeted, tailored, and timely weather and climate information, has gained momentum, but requires improved understanding of user needs. This article identifies the opportunities and barriers to the use of climate services for planning in Malawi, to identify the types of information that can better inform future adaptation decisions in sub-Saharan Africa. From policy analysis, stakeholder interviews, and a national workshop utilizing serious games, it is determined that only 5–10 day and seasonal forecasts are currently being used in government decision making. Impediments to greater integration of climate services include spatial and temporal scale, accessibility, timing, credibility and the mismatch in timeframes between planning cycles (1–5 years) and climate projections (over 20 years). Information that could more usefully inform planning decisions includes rainfall distribution within a season, forecasts with 2–3 week lead times, likely timing and location of extreme events in the short term (1–5 years), and projections (e.g. rainfall and temperature change) in the medium term (6–20 years). Development of a national set of scenarios would also make climate information more accessible to decision makers, and capacity building around such scenarios would enable its improved use in short- to medium-term planning. Improved climate science and its integration with impact models offer exciting opportunities for integrated climate-resilient planning across sub-Saharan Africa. Accrual of positive impacts requires enhanced national capacity to interpret climate information and implement communication strategies across sectors. Policy relevance For climate services to achieve their goal of improving adaptation decision making, it is necessary to understand the decision making process and how and when various types of weather and climate information can be incorporated. Through a case study of public sector planning in Malawi, this article highlights relevant planning and policy-making processes. The current use of weather and climate information and needs, over various timescales – sub-annual to short term (1–5 years) to medium term (6–20 years) – is outlined. If climate scientists working with boundary organizations are able to address these issues in a more targeted, sector-facing manner they will improve the uptake of climate services and the likelihood of climate-resilient decisions across sub-Saharan Africa.
Poverty and Income Inequality Measurement: Accommodating a Role for Owner‐Occupied Housing

The most common method used in Australia to identify whether an income unit is in poverty is to compare the income unit's disposable cash income with a cash income-based poverty line adapted to each income unit's needs. If disposable cash income lies below the poverty threshold then the income unit is deemed to be in poverty. This approach was adopted in the Commission of Inquiry into Poverty (Henderson, 1975) and in numerous subsequent pieces of poverty-related research in Australia.