Miracle-dz/UniFAR-FTUs huggingface dataset:
How Important Is Option-Implied Volatility for Pricing Credit Default Swaps ?

This paper empirically examines the role of option-implied volatility in determining the credit default swap (CDS) spread. Using Þrm-level time-series regressions, we Þnd that implied volatility dominates historical volatility in explaining CDS spreads. More importantly, the advantage of implied volatility is concentrated among Þrms with lower credit ratings, higher option volume and open interest, and Þrms that have experienced important credit events such as a signiÞcant increase in the level of CDS spreads. To accommodate the inherently nonlinear relation between CDS spread and volatility, we estimate a structural credit risk model called CreditGrades.  Assessing the performance of the model with either implied or historical volatility as input, we reach broadly similar conclusions. Further analysis reveals that for individual stocks, implied volatility generally dominates historical volatility in predicting future volatility. However, the ability of implied volatility to explain CDS spreads stems from a combination of better prediction of future volatility and the volatility risk premium embedded in option prices.
Higher Theological Seminary of The Order of Friars Minor Capuchin – Cracow, Poland STRATEGIES OF COPING WITH TRANSGRESSOR - POLISH VALIDATION OF TRIM-18 QUESTIONNAIRE

The aim of this paper is to present the results of Polish validation of Transgression – Related Interpersonal Motivations questionnaire (TRIM-18) by McCullough, Root, and Cohen (2006) which measures the phenomena of forgiveness. The article contains a description of the procedure of Polish translation, the results of the test reliability, discriminant and confirmatory validity. The study was conducted among 530 participants aged between 18 and 84 (345 females and 185 males). Eleven questionnaires were used for assessing the validity of the measurement. This study confirms that the structure of Polish TRIM-18 is relevant to the English language version. Polish TRIM-18 is also a very reliable tool. It can be successfully used in Polish conditions.
Tinea Capitis in Adolescent : A Case Report

Background: Tinea capitis is a dermatophyte infection of the scalp, eyebrows, and eyelashes with a propensity for attacking hair shafts and follicles, commonly affect children. The treatment remains the same between child, adolescent and adult Purpose: To evaluate the clinical manifestation, species causing agent, and management of tinea capitis. Case: An adolescent woman, 16 years old, body weight 33 kg with primary amennorhea came to Dermatovenereology Outpatient Clinic Dr. Soetomo Hospital because of baldness on her head since 3 weeks before admission. At first the lession was appeared as an itchy redness patches covered with thin scale followed by hairs turning into grey, lusterless and easily to pulled out leaving a patch of baldness. Dermatological examination demonstrated a well defined 10 cm x 10 cm alopecia with mild erythematous plaque covered with thin scale located in the parieto-occipitalis area. Wood’s lamp examination revealed bright green fluorescence. Potassium hydroxide examination showed ectothrix spores. The positive result of fungal culture on Sabouraud’s Dextrose Agar (SDA) was identified as Microsporum audouinii. Patient was diagnosed with tinea capitis greypatch type, and was treated with oral griseofulvin 125 mg microsize 2x3 tablets per day and ketoconazole 2% shampoo once a day. At 6 weeks of follow up, the lesion of her scalp was improved, the itchy was decreased, Wood’s Lamp and Potassium hydroxide examination were negative. Discussion: In patient with amenorrhea, the progesterone level was low, the sebum production was decreased, as the consequence free fatty acid component which has fungistatic and fungisidal effect also low and increase the risk of tinea capitis. Griseofulvin remains the mainstay of treatment for tinea capitis caused by Microsporum audounii. Conclusions: The wood’s lamp can detect Microsporum sp. infection with its greenish fluorescence. Definitive diagnosis and exact identification of the causative organism of tinea capitis could be determined by culture.
Interactive comment on “ A systematic comparison of bias correction methods for paleoclimate simulations

Dear authors, Two reviewers have now posted comments on your manuscript. Both have raised substantive issues. Although I note that Referee #2 has recommended rejection, I am willing to consider a revised manuscript. However, this would be dependent upon you comprehensively revising the manuscript in line with the comments that you have received. Therefore, please ensure that you respond carefully and thoroughly to each review comment. Steven Phipps, Handling Editor C1
The Open Access Israeli Journal of Aquaculture – Bamidgeh

The acute toxicity of nitrite (133.33, 266.66, 399.99mg/L) to 15 days posthatched Lates calcarifer (barramundi) was studied by semi-static bioassay method; 0 mg/L nitrite was used as control. Samples were obtained at 0, 6, 12, 24, 36, 48, 72 and 96 h respectively to measure and analyze the activity of antioxidant, digestive enzymes, and concentration of serum cortisol. Nitrite concentration and exposure time significantly affected the antioxidant and digestive enzymes activities. By the end of the experiment, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in the experimental group were significantly higher than in the control group, while peroxidase (POD) and catalase activities were significantly lower than in the control group except for in higher concentrations. Differing from POD and catalase, the acid phosphatase (ACP) activity of sub-concentration treatment was significantly higher than in the control group. Amylase activity in the nitrite stressed group was significantly lower than the control group, while the results of protease and lipase activity were reversed. Cortisol activity was delayed because of acute nitrite stress in the barramundi. Lates calcarifer showed certain short-term tolerance to nitrite stress. Results from the present study indicate that nitrite stress stimulates the responses of antioxidant and digestive enzyme activity and cortisol in fish, and these parameters can be used as physical indicators of stress. Published as an open-access journal by the Society of Israeli Aquaculture & Marine Biotechnology (SIAMB). To read papers free of charge, please register online at the website http://www.aquaculturehub. org/group/israelijournalofaquaculturebamidgehija The sale of IJA papers is strictly forbidden
Population density , sex ratio and body size in a population of Salamandra atra atra on the Dolomites

Salamandra atra atra is the most widespread subspecies of the Alpine Salamander, both in Italy and in the other parts of the species distribution range. However, in particular for Italian populations, its ecology and demographic parameters are poorly known. We studied biometry (length, mass, body condition index) and demography (population density, sex ratio, proportion of gravid females) of this fully terrestrial salamander in the “PaneveggioPale di San Martino” Natural Park in the Dolomites. We used removal methods to estimate abundance on a surface of about 1000 m2. Density estimate of adults was 472 salamanders/ha, which falls within the density estimates that are available for this taxon. Sexes did not differ significantly in size and body mass. Body sizes of adults included the maximum sized salamander recorded in Italy. There was a high rate of gravid females (50%), which were comparable in size with non-gravid females. Males and non-gravid females did not show significant differences in their body condition index.
Escaping the Doldrums of Non-Innovation: Path From Non-Innovator to Radical Innovator

An important challenge for any firm is not only to become innovative, but also to strengthen the innovative capabilities over time, to at least remain innovative or even increase innovativeness. However, statistics repeatedly report that a significant share of firms across Europe are not able to break out of the non-innovative stage and hence jeopardize their own future competitiveness. This study investigates how the adoption and extent of use of specific organizational practices and production technologies discriminate between firms that are not innovative, innovative and radically innovative in new products. Based on survey data for manufacturing firms from five European countries, the article finds that to change from being non-innovative to incrementally innovative, firms benefit from adopting process technologies like e.g. rapid prototyping, whereas the further change from being incrementally innovative to become radically product-innovative requires implementation of organizational innovations like e.g. implementation of knowledge base systems and arrangements for flexible working hours. Interestingly, the process technologies do not statistically support this additional increase in innovative performance. The article discusses the paths towards increased product innovativeness, where our study highlights the importance of organizational innovation practices, leaving a limited role for process innovative technologies. ESCAPING THE DOLDRUMS OF NON-INNOVATION: PATH FROM NON-INNOVATOR TO RADICAL INNOVATOR
Iron speciation in minerals and glasses probed by M2/3-edge x-ray Raman scattering spectroscopy

We present a spectroscopic study of the iron M2/3-edge for several minerals and compounds to reveal information about the oxidation state and the local coordination of iron. We describe a novel approach to probe the iron M2/3-edge bulk sensitively using xray Raman scattering. Significant changes in the onset A. Nyrow, C. Sternemann, K. Mende and M. Tolan Fakultät Physik / DELTA, Technische Universität Dortmund, Dortmund, D-44221, Germany E-mail: alexander.nyrow@tu-dortmund.de; christian.sternemann@tu-dortmund.de M. Wilke Deutsches GeoForschungsZentrum, Section 3.3, Potsdam, D-14473, Germany R. A. Gordon PNCSRF, APS Sector 20, Argonne, IL, USA 60439 H. Yavaş Photon Science at DESY, D-22607 Hamburg, Germany L. Simonelli European Synchrotron Radiation Facility, Grenoble Cedex, F-38043, France Present address: CELLS ALBA Synchrotron Light Facility, Barcelona, Spain N. Hiraoka National Synchrotron Radiation Research Center, Hsinchu 30076, Taiwan Ch. J. Sahle and S. Huotari Department of Physics, P.O. Box 64, University of Helsinki, FI-00014 Helsinki, Finland G. B. Andreozzi Dipartimento di Scienze della Terra, Sapienza Università di Roma, I-00185 Rome, Italy A. B. Woodland Institut für Geowissenschaften, Universität Frankfurt, Altenhöferallee 1, D-60438 Frankfurt, Germany J. S. Tse Department of Physics and Engineering Physics, University of Saskatchewan, Saskatoon, Canada S7N 5E2 and shape of the Fe M2/3-edge were observed on ferrous and ferric model compounds with Fe in octahedral and tetrahedral coordination. Simulation of the spectra is possible using an atomic multiplet code, which potentially allows determination of e.g. crystal field parameters in a quantitative manner. A protocol is discussed that allows for determination of the Fe oxidation state in compounds by linear combination of spectra of ferric and ferrous end-members. The presented results demonstrate the capabilities of Fe M2/3-edge spectroscopy by x-ray Raman scattering to extract information on the ratio of trivalent to total iron Fe/ ∑ Fe and local coordination. As x-ray Raman scattering is performed with hard x-rays, this approach is suitable for in-situ experiments at high pressure and temperature. It thus may provide indispensable information on oxidation state, electronic structure and local structure of materials that are important for physical and chemical processes of the deep Earth.
Titre : Title : Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures Auteurs :

Recombinant yeast pyruvate carboxylase (PYC2) expression was previously shown to be an effective metabolic engineering strategy for reducing lactate formation in a number of relevant mammalian cell lines, but, in the case of CHO cells, did not consistently lead to significant improvement in terms of cell growth, product titer and energy metabolism efficiency. In the present study, we report on the establishment of a PYC2-expressing CHO cell line producing a monoclonal antibody and displaying a significantly altered lactate metabolism compared to its parental line. All clones exhibiting strong PYC2 expression were shown to experience a significant and systematic metabolic shift toward lactate consumption, as well as a prolonged exponential growth phase leading to an increased maximum cell concentration and volumetric product titer. Of salient interest, PYC2-expressing CHO cells were shown to maintain a highly efficient metabolism in fed-batch cultures, even when exposed to high glucose levels, thereby alleviating the need of controlling nutrient at low levels and the potential negative impact of such strategy on product glycosylation. In bioreactor operated in fed-batch mode, the higher maximum cell density achieved with the PYC2 clone led to a net gain (20%) in final volumetric productivity. Crown Copyright © 2015 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
The Distribution of Gains from Globalization, WP/18/54, March 2018

We study economic globalization as a multidimensional process and investigate its effect on incomes. In a panel of 147 countries during 1970-2014, we apply a new instrumental variable, exploiting globalization’s geographically diffusive character, and find differential gains from globalization both across and within countries: Income gains are substantial for countries at early and medium stages of the globalization process, but the marginal returns diminish as globalization rises, eventually becoming insignificant. Within countries, these gains are concentrated at the top of national income distributions, resulting in rising inequality. We find that domestic policies can mitigate the adverse distributional effects of globalization. JEL Classification Numbers: F62, F63, I24, O15, O47
A systematic review of how studies describe educational interventions for evidence-based practice

Background: The aim of this systematic review was to identify which information is included when reporting educational interventions used to facilitate foundational skills and knowledge of evidence-based practice (EBP) training for health professionals. This systematic review comprised the first stage in the three stage development process for a reporting guideline for educational interventions for EBP. Methods: The review question was ‘What information has been reported when describing educational interventions targeting foundational evidence-based practice knowledge and skills? ’ MEDLINE, Academic Search Premier, ERIC, CINAHL, Scopus, Embase, Informit health, Cochrane Library and Web of Science databases were searched from inception until October December 2011. Randomised and non-randomised controlled trials reporting original data on educational interventions specific to developing foundational knowledge and skills of evidence-based practice were included. Studies were not appraised for methodological bias, however, reporting frequency and item commonality were compared between a random selection of studies included in the systematic review and a random selection of studies excluded as they were not controlled trials. Twenty-five data items were extracted by two independent reviewers (consistency > 90%). Results: Sixty-one studies met the inclusion criteria (n = 29 randomised, n = 32 non-randomised). The most consistently reported items were the learner’s stage of training, professional discipline and the evaluation methods used (100%). The least consistently reported items were the instructor(s) previous teaching experience (n = 8, 13%), and student effort outside face to face contact (n = 1, 2%). Conclusion: This systematic review demonstrates inconsistencies in describing educational interventions for EBP in randomised and non-randomised trials. To enable educational interventions to be replicable and comparable, improvements in the reporting for educational interventions for EBP are required. In the absence of a specific reporting guideline, there are a range of items which are reported with variable frequency. Identifying the important items for describing educational interventions for facilitating foundational knowledge and skills in EBP remains to be determined. The findings of this systematic review will be used to inform the next stage in the development of a reporting guideline for educational interventions for EBP.
GENETIC DIVERSITY OF MYCOBACTERIUM AVIUM subsp. HOMINISSUIS STRAINS ISOLATED IN ITALY BASED ON VNTR LOCI ANALYSIS

Abstract.Background. Mycobacterium avium subsp. hominissuis (MAH) is an important pathogen responsible for most of the human-associated nontuberculous mycobacteria infections. Over the past few decades the incidence of MAH infections is increasing in Italy, as in many countries worldwide. The present study is aimed to elucidate the genetic characteristics of MAH strains isolated from human patients using VNTR typing and to show the genetic relatedness among them.Methods. The genetic diversity of 108 human isolates of MAH was determined by VNTR analysis targeting 8 loci, coded 32, 292, X3, 25, 3, 7, 10 and 47.Results. The VNTR analysis revealed 25 distinct VNTR patterns; of these, 13 patterns were unique, while 12 patterns were shared by 2 or more isolates, thus yielding 12 clusters including a total of 95 isolates. The discriminatory power of our VNTR analysis yielded an HGDI of 0.990, indicating that VNTR typing has an excellent discriminatory power. No association of a particular VNTR pattern with a particular clinical feature, such as the disseminated, pulmonary or extrapulmonary type of infection, was observed. Minimum spanning tree analysis showed that 21 VNTR patterns, occurring either as clustered or unique isolates, differed from the nearest one for one allelic variation.Conclusions. The results obtained through the VNTR analysis showed that most MAH strains displayed a close genetic relationship. This high phylogenetic proximity of the VNTR loci over a long time period supports the concept that the MAH genotype is highly homogeneous in our geographical area, suggesting the hypothesis of the presence of possible sources of infection and transmission pathways at the local level.
UvA-DARE ( Digital Academic Repository ) Comments on AdS 2 Gravity

We revisit some properties of AdS2 Einstein-Maxwell gravity with the aim of reconciling apparently conflicting results in prior literature. We show that the two dimensional theory can be obtained as a dimensional reduction of the three dimensional Einstein gravity with the CSS boundary condition [3]. In general, this theory on AdS2 can be viewed as an effective theory of the near horizon geometry of a (near-)extremal black hole. We provide an interpretation of our results in terms of the microscopic description of an extremal black hole.
BENTHIC MACROINVERTEBRATE DIVERSITY AND FUNCTIONAL FEEDING GROUPS IN RELATION TO PHYSICOCHEMICAL FACTORS IN SANJIANG PLAIN WETLANDS , NORTHEAST CHINA

Sanjiang plain wetland is the largest freshwater ecosystem in northeast China, and with its richness in animal and plant species, it displays a high biodiversity. This study provides information about benthic macroinvertebrate diversity and functional groups in association with physicochemical parameters in wetland habitats of Sanjiang plain. Benthic macroinvertebrate samples were collected using a D-frame aquatic net. Shannon-Wiener, Simpson and Pileou’s evenness indices were calculated in terms of abundance. The relationship between measured physicochemical variables and benthic macroinvertebrate functional feeding groups (FFGs) was explored using CCA. A total of 57 macroinvertebrate taxa were collected from the 16 sampling sites. Aquatic insects were the most abundant with 11 families, Dytiscidae, Chironomidae, Leptophlebiidae, Belostomatidae, Corixidae, Gerridae, Corduliidae, Gomphidae, Macromiinae, Libellulidae and Phryganeidae. Chironomids were the most diverse and abundant with 26 taxa. The metrics of abundance, Shannon-Wiener, Simpson and Pileou’s evenness indices differed significantly among the 16 sampling sites (p = 0.0163, p = 0.0092, p = 0.0474, p = 0.0222, respectively). The findings showed that these 57 benthic macroinvertebrate taxa were categorized in six functional feeding groups, including 19 predators, 15 gathering-collectors, 7 scrapers, 6 filtering-collectors, 5 omnivores and 5 shredders. CCA results displayed that benthic macroinvertebrate functional feeding groups had strong relationships with the physicochemical characteristics in the wetlands of Sanjiang plain.
Detection of cytogenetic and genotoxic effects of gamma radiation on M1 generation of three varieties of Triticum aestivum L.

The effects of Cobalt (Co) gamma radiation on cell division and chromosomal structure in M1 generations of three varieties (NKU Lider, Bezostaja and GK Beke’s) of Triticum aestivum L. genotypes were determined in this study. To understand and compare the tolerance of on three bread wheat varieties to gamma radiation (100, 200 and 300Gy), the frequency of mitotic index, phase indices and genotoxicity rate were scored and statistically interpreted under irradiated and unirradiated conditions, respectively. In parallel with the increasing radiation dose, mean mitotic index rate decreased in NKU Lider and GK Beke’s genotypes. 100Gy Co gamma radiation application of NKU Lider was the most powerful genotype to increase mitotic activity as compared to other genotypes. However; depending on increasing dose of gamma radiation, cell division decreased in all studied genotypes except 200Gy application of Bezostaja genotype. Moreover, genotoxicity index of M1 generation in NKU Lider genotype was decreased in all studied radiation doses with the increasing dose of Co. Furthermore, three different variety of T. aestivum L. seeds treated with different doses of Co gamma radiation showed many aberrant chromosomes such as disorderly prophase, stickiness, uncoiling chromosomes, disrupted equatorial plate, fragment, micronucleus, alignment anaphase, fault polarization, anaphase and telophase bridges, lagging chromosomes and stickiness in all mitotic phases. Consequently, the results suggest that gamma radiation effects are specific to the radiation dose and species, and even show different responses in different varieties of the same species.