Miracle-dz/UniFAR-FTUs huggingface dataset:
A Prediction Rule for Overall Survival in Non-Small-Cell Lung Cancer Patients with a Pathological Tumor Size Less Than 30 mm

We sought to develop and validate a clinical nomogram model for predicting overall survival (OS) in non-small-cell lung cancer (NSCLC) patients with resected tumors that were 30 mm or smaller, using clinical data and molecular marker findings. We retrospectively analyzed 786 NSCLC patients with a pathological tumor size less than 30 mm who underwent surgery between 2007 and 2017 at our institution. We identified and integrated significant prognostic factors to build the nomogram model using the training set, which was subjected to the internal data validation. The prognostic performance was calibrated and evaluated by the concordance index (C-index) and risk group stratification. Multivariable analysis identified the pathological tumor size, lymph node metastasis, and Ki-67 expression as independent prognostic factors, which were entered into the nomogram model. The nomogram-predicted probabilities of OS at 1 year, 3 years, and 5 years posttreatment represented optimal concordance with the actual observations. Harrell's C-index of the constructed nomogram with the training set was 0.856 (95% CI: 0.804-0.908), whereas TNM staging was 0.814 (95% CI: 0.742-0.886, P = 5.280221e − 13). Survival analysis demonstrated that NSCLC subgroups showed significant differences in the training and validation sets (P < 0.001). A nomogram model was established for predicting survival in NSCLC patients with a pathological tumor size less than 30 mm, which would be further validated using demographic and clinicopathological data. In the future, this prognostic model may assist clinicians during treatment planning and clinical studies.
Low birth weight in a municipality in the southeast region of Brazil.

OBJECTIVE to identify the prevalence of low birth weight in the city of São Paulo. METHOD epidemiological cross-sectional study with data collected by means of the Brazilian Live Birth Information System related to births occurred in the city of São Paulo between 2007 and 2013. Maternal, gestational, childbirth, and neonatal variables were analyzed descriptively and by association. RESULTS 9.65% (1,342,655) of live births were underweight (mean of 3234.55 grams in the term group and 2312.17 in the pre-term group) with a mean maternal age of 27.53 years old. The risk factors identified include maternal age, not having a partner, low maternal level of education, other race rather than white, pre-term pregnancy, multiple births, low number of prenatal check-ups, and cesarean delivery. CONCLUSION knowledge of this evidence favors planning the care provided by defining strategies to reduce it and consequently improve maternal and infant health care.
The Self-Perceived Knowledge of Special Education Administrators in Kuwait

Administrators of special education identify and provide essential services for students with disabilities. No research has been conducted on the perceptions of Kuwait’s special education administrators regarding their knowledge in key special education standard areas. This study examined those perceptions and the extent to which they are influenced by administrators’ experience, qualification level, school district, or educational setting. Quantitative data were collected by surveying 62 special education administrators and were analyzed using descriptive statistics, a one-way ANOVA, and Spearman’s rank-order correlations. The results indicated that the participants consider themselves most knowledgeable in two areas (1) collaboration and (2) leadership and policy—but less knowledgeable in the areas of research and inquiry, individual and program evaluation, and professional development and ethical practice. A significant relationship was found between self-assessment ratings and the educational setting where the administrator was working. Recommendations are made with the aim of enhancing the knowledge and development of special education administrators. The limitations of the study and further research possibilities are also discussed.
Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression.

AIM To evaluate the effect of resveratrol, alone and in combination with fenofibrate, on fructose-induced metabolic genes abnormalities in rats. METHODS Giving a fructose-enriched diet (FED) to rats for 12 wk was used as a model for inducing hepatic dyslipidemia and insulin resistance. Adult male albino rats (150-200 g) were divided into a control group and a FED group which was subdivided into 4 groups, a control FED, fenofibrate (FENO) (100 mg/kg), resveratrol (RES) (70 mg/kg) and combined treatment (FENO + RES) (half the doses). All treatments were given orally from the 9(th) week till the end of experimental period. Body weight, oral glucose tolerance test (OGTT), liver index, glucose, insulin, insulin resistance (HOMA), serum and liver triglycerides (TGs), oxidative stress (liver MDA, GSH and SOD), serum AST, ALT, AST/ALT ratio and tumor necrosis factor-α (TNF-α) were measured. Additionally, hepatic gene expression of suppressor of cytokine signaling-3 (SOCS-3), sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), malonyl CoA decarboxylase (MCD), transforming growth factor-β1 (TGF-β1) and adipose tissue genes expression of leptin and adiponectin were investigated. Liver sections were taken for histopathological examination and steatosis area were determined. RESULTS Rats fed FED showed damaged liver, impairment of glucose tolerance, insulin resistance, oxidative stress and dyslipidemia. As for gene expression, there was a change in favor of dyslipidemia and nonalcoholic steatohepatitis (NASH) development. All treatment regimens showed some benefit in reversing the described deviations. Fructose caused deterioration in hepatic gene expression of SOCS-3, SREBP-1c, FAS, MDA and TGF-β1 and in adipose tissue gene expression of leptin and adiponectin. Fructose showed also an increase in body weight, insulin resistance (OGTT, HOMA), serum and liver TGs, hepatic MDA, serum AST, AST/ALT ratio and TNF-α compared to control. All treatments improved SOCS-3, FAS, MCD, TGF-β1 and leptin genes expression while only RES and FENO + RES groups showed an improvement in SREBP-1c expression. Adiponectin gene expression was improved only by RES. A decrease in body weight, HOMA, liver TGs, AST/ALT ratio and TNF-α were observed in all treatment groups. Liver index was increased in FENO and FENO + RES groups. Serum TGs was improved only by FENO treatment. Liver MDA was improved by RES and FENO + RES treatments. FENO + RES group showed an increase in liver GSH content. CONCLUSION When resveratrol was given with half the dose of fenofibrate it improved NASH-related fructose-induced disturbances in gene expression similar to a full dose of fenofibrate.
1-aminocyclopropane-1-carboxylate oxidase activity limits ethylene biosynthesis in Rumex palustris during submergence.

Submergence strongly stimulates petiole elongation in Rumex palustris, and ethylene accumulation initiates and maintains this response in submerged tissues. cDNAs from R. palustris corresponding to a 1-aminocyclopropane-1-carboxylate (ACC) oxidase gene (RP-ACO1) were isolated from elongating petioles and used to study the expression of the corresponding gene. An increase in RP-ACO1 messenger was observed in the petioles and lamina of elongating leaves 2 h after the start of submergence. ACC oxidase enzyme activity was measured in homogenates of R. palustris shoots, and a relevant increase was observed within 12 h under water with a maximum after 24 h. We have shown previously that the ethylene production rate of submerged shoots does not increase significantly during the first 24 h of submergence (L.A.C.J. Voesenek, M. Banga, R. H. Thier, C.M. Mudde, F.M. Harren, G.W.M. Barendse, C.W.P.M. Blom [1993] Plant Physiol 103: 783-791), suggesting that under these conditions ACC oxidase activity is inhibited in vivo. We found evidence that this inhibition is caused by a reduction of oxygen levels. We hypothesize that an increased ACC oxidase enzyme concentration counterbalances the reduced enzyme activity caused by low oxygen concentration during submergence, thus sustaining ethylene production under these conditions. Therefore, ethylene biosynthesis seems to be limited at the level of ACC oxidase activity rather than by ACC synthase in R. palustris during submergence.
Positioning new treatments in the management of immune thrombocytopenia

Immune thrombocytopenia (ITP) is a syndrome characterized by low platelet counts and an increased risk of bleeding. For most children, ITP is a self‐limiting disease; however, for some children and most adults, thrombocytopenia can become chronic. Newer therapies for ITP include rituximab and thrombopoietin (TPO) receptor agonists. Rituximab is a useful second‐line therapy and may be splenectomy‐sparing. Thrombopoeitin receptor agonists have demonstrated large treatment effects with respect to increasing platelet levels; however, they require maintenance dosing. This review summarizes how these new agents might be positioned in the management of patients with chronic ITP. Pediatr Blood Cancer 2012; 60: S19–S22. © 2012 Wiley Periodicals, Inc.
Design principles for support in developing students’ transformative inquiry skills in Web-based learning environments

The aim of this explorative study was to find the factors limiting sixth-grade learners’ outcomes in acquiring skills related to the transformative inquiry learning processes as well as to analyse the interrelations between inquiry skills in order to develop an optimal support system for designing Web-based inquiry learning environments. A Web-based learning environment ‘Young Scientist’ was developed and applied to the domain of integrated science. The skill of identifying the correct research questions appeared to be a prerequisite for formulating research questions. When students understand how to identify the research questions correctly, there is no need for supporting formulation of research questions or hypotheses. We have found that at the stages of analysing data and inferring, students have to be provided with the tools to activate their prior knowledge, assignments help to organize their work into manageable sections, and reflective support or adaptive feedback to relate the results achieved with the process of inquiry. Our findings demonstrate that the effectiveness of inquiry learning can be strongly influenced by regulative support; however, a particular level of initial inquiry knowledge in theoretical context is also needed in order to develop inquiry skills in a situational context.
Regulation of the L‐Type Ca2+ Channel Current in Rat Pinealocytes

Abstract : In the present study, the role of phosphoprotein phosphatase in the regulation of L‐type Ca2+ channel currents in rat pinealocytes was investigated using the whole‐cell version of the patch‐clamp technique. The effects of three phosphatase inhibitors, calyculin A, tautomycin, and okadaic acid, were compared. Although all three inhibitors were effective in inhibiting the L‐type Ca2+ channel current, calyculin A was more potent than either tautomycin or okadaic acid, suggesting the involvement of phosphoprotein phosphatase‐1. To determine the kinase involved in the regulation of these channels, cells were pretreated with H7 (a nonspecific kinase inhibitor), H89 (a specific inhibitor of cyclic AMP‐dependent kinase), KT5823 (a specific inhibitor of cyclic GMP‐dependent kinase), or calphostin C (a specific inhibitor of protein kinase C). Pretreatment with either H7 or calphostin C decreased the inhibitory effect of calyculin A on the L‐type Ca2+ channel current. In contrast, pretreatment with H89 or KT5823 had no effect on the inhibition caused by calyculin A. Based on these observations, we conclude that basal phosphatase activity, probably phosphoprotein phosphatase‐1, plays an important role in the regulation of L‐type Ca2+ channel currents in rat pinealocytes by counteracting protein kinase C‐mediated phosphorylation.
Women’s Center Staff Perceptions of the Campus Climate on Sexual Violence

Background: Sexual assault is a major public health problem disproportionately affecting women on college and university campuses. As sexual assault is often unreported, survivors may not have the access to resources and services that are helpful in healing. Campus-based women’s centers provide a comfortable place and resource to address women’s issues on campus. Individuals who work in these centers have open communication channels with students and a role in the administrative structure that may provide a unique understanding of survivors, the student environment, and the institutional context regarding sexual assault. Objective: The purpose of this study was to understand the perceptions of campus-based women’s center staff on college and university campuses, specifically regarding campus-based responses to sexual assault. Methods: Participants responded electronically to six open-ended survey questions. Data were analyzed using a qualitative content analysis approach to identify key themes present within the data. Results: Key concepts identified included respect, trust, confidentiality, trained professionals, and comprehensive and consistent response. Conclusions: The findings provide an early description of the perceptions of staff in campus-based women’s centers related to prevention, reporting, and response to sexual violence on campuses and can be used to inform campus policies and practices as well as forensic and college-based nursing practice.
Food Insufficiency and Material Hardship in Post-TANF Welfare Families

This Aicle uses a newly available dataset on welfare recipients in Michigan to examine the prevalence and correlates offood insufficiency and material hardship in the new welfare caseload. The authors found that twentyfive percent ofrecipients report that they sometimes or often did not have enough to eat, and that thirty-six percent experienced one or more of the following hardships:food insufficiency, eviction, homelessness, or having their utilities cut off. The strongest predictors offood insufflciency and/or material hardship were: lack of a high school diploma, low work experience, alcohol and drug dependence, physical health problems, depression, and domestic violence.
Effect on Group Detection Based on Human Proximity for Human Relationship Extraction in Daily Life

In this paper, we investigate an effect on group detection based on human proximity depending on RSSI values, measured by BLE signals. To realize the investigation, we present a novel method for detecting groups. In the method, we developed a smartphone application for measurement of RSSI values of BLE, and determine a threshold of RSSI values which selected experimentally by making the propagation characteristics of BLE signal. To show the effectiveness of proposed method, we evaluated the method through a series of experiments and investigated the effect on group detection by the difference of human proximity. As the results, we found that the group detection was affected by the difference of human proximity.
Myasthenic syndrome caused by mutation of the SCN4A sodium channel

In a myasthenic syndrome associated with fatigable generalized weakness and recurrent attacks of respiratory and bulbar paralysis since birth, nerve stimulation at physiologic rates rapidly decremented the compound muscle action potential. Intercostal muscle studies revealed no abnormality of the resting membrane potential, evoked quantal release, synaptic potentials, acetylcholine receptor channel kinetics, or endplate ultrastructure, but endplate potentials depolarizing the resting potential to -40 mV failed to excite action potentials. Pursuing this clue, we sequenced SCN4A encoding the skeletal muscle sodium channel (Nav1.4) and detected two heteroallelic mutations involving conserved residues not present in 400 normal alleles: S246L in the S4/S5 cytoplasmic linker in domain I, and V1442E in the S3/S4 extracellular linker in domain IV. The genetically engineered V1442E-Na channel expressed in HEK cells shows marked enhancement of fast inactivation close to the resting potential, and enhanced use-dependent inactivation on high-frequency stimulation; S246L is likely a benign polymorphism. The V1442E mutation in SCN4A defines a novel disease mechanism and a novel phenotype with myasthenic features.
Postoperative CEA is a better prognostic marker than CA19-9, hCGβ or TATI after resection of colorectal liver metastases

Liver metastases of colorectal cancer can be operated with a curative intent in selected cases. However, more than half of the patients have a recurrence. The aim of this study was to evaluate the prognostic and predictive value of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), human chorionic gonadotropin β (hCGβ) and tumour-associated trypsin-inhibitor (TATI) in colorectal cancer patients before and 3 months after resection of liver metastases. Marker concentrations were determined in blood samples from 168 colorectal cancer patients, who underwent liver resection between the years 1998 and 2007 at Helsinki University Hospital, Finland. The samples were taken before and 3 months after curative resection. Increased concentrations of CEA (>5 µg/L) and hCGβ (>1 pmol/L) 3 months after liver resection correlated with recurrence and impaired overall survival and increased CA19-9 (>26 kU/L) with impaired overall survival, but postoperative TATI was not prognostic. Preoperatively elevated CEA and CA19-9 correlated with impaired overall survival, but not with recurrence. Neither preoperative hCGβ nor TATI was prognostic. In conclusion, CEA is a useful prognostic marker, when measured 3 months after resection of colorectal liver metastases. CA19-9 also has prognostic significance and may have additional value.
Exchange Rate Dynamics with Chartists, Fundamentalists, and Rational Speculators in the Foreign Exchange Market

This paper extends previous work on speculative dynamics in the foreign exchange market. The analysis shows how the behavior of chartists, fundamentalists and rational speculators, together with uncertainty about the long-run equilibrium exchange rate level, can result in fluctuations of the spot rate triggered by a random shock to the market. Although the exact exchange rate path depends on the extent of the shock and on specific values of model parameters, the heterogeneity of expectations can explain several characteristics of short-term exchange rate developments, which have often been emphasized in empirical studies on exchange rate dynamics.
Becoming a mother: a study exploring occupational change in first-time motherhood

Having a first baby is considered a major life event, due to significant role change impacting on the ordinary and familiar activities the new mother performs every day. The aim of this study was to explore changes in the occupational lives of first time mothers. A concurrent nested strategy of enquiry was used. Quantitative data via the Modified Interest Checklist and the Role Checklist was nested within the predominantly qualitative data collection in the form of semi-structured interviews. Six first time mothers, who were two and a half years post motherhood and aged between 28 and 42 years, participated in this study. The findings indicate that 'new mothers' engaging in a balanced lifestyle pre-motherhood in the areas of self-care, leisure, productivity and rest experience a period of occupational disruption and occupational imbalance before adapting into motherhood through activities, tasks and finally occupations. These mothers' occupational lives are productivity dominant with most of their time being spent in paid employment and/or performing homecare/family care activities. Their occupational lives are also obligatory dominant, for example, they are performing activities they need to do to enable them to fulfil their role as mother, as opposed to activities they choose to do. Also evident is a daily process of change as individuals adapt into motherhood.
Comparison of ExPress Mini-Device Implantation Alone or Combined with Phacoemulsification for the Treatment of Open-Angle Glaucoma

We propose comparative assessment of the effectiveness of two surgical methods for the treatment of open-angle glaucoma: (1) ExPress mini-device implantation combined with phacoemulsification and (2) ExPress mini-device implantation alone. In this prospective study, 81 patients (88 phakic eyes) with uncontrolled open-angle glaucoma enrolled for surgery. They were assigned two groups, those with coexisting cataracts (46 eyes; P-ExPress group) and those with glaucoma alone (42 eyes; ExPress group). The follow-up period was 12.9 ± 0.4 months in P-ExPress and 12.2 ± 0.6 months in ExPress group. In both groups the following parameters were measured: best corrected visual acuity (BCVA), intraocular pressure (IOP), number of complications and necessary postoperative interventions, and number of glaucoma medications. The IOP at the end of follow-up was similar in both groups (18.8 ± 5.9 versus 18.1 ± 4.8 mmHg; P = 0.814). There were no statistical differences in the average number of glaucoma medications between ExPress and P-ExPress groups (0.9 ± 1.65 versus 1.3 ± 1.7; P = 0.419) as well as in the number of postoperative complications (26 versus 21%; P = 0.179 in the P-ExPress and ExPress groups, resp.). Both methods are safe and effective for the surgical treatment of open-angle glaucoma. Coexistence of cataracts does not constitute a compelling contraindication for combined surgery.
Components of visual bias: a multiplicative hypothesis

Attentional selection can be viewed as having two aspects: selection with respect to particular objects and selection with respect to particular categories. Both aspects are mathematically modeled in the theory of visual attention (TVA). In this paper, we expand the rate equation of the TVA and propose that the visual bias toward seeing an object x as a member of category i is a product of three factors: the expectancy (prior probability) of being presented with members of category i, the subjective importance (utility) of seeing objects in category i as members of that category, and the general level of alertness. Together, the three factors also determine the level of arousal in the visual system. The hypothesized multiplicative interaction between the three components of visual bias seems consistent with the function of an ideal observer and also paves the way for a Bayesian interpretation of the TVA.
Compliance with periodic surveillance for Von-Hippel-Lindau disease

Purpose: To assess compliance with a periodic surveillance regimen for Von Hippel-Lindau disease.Methods: In this nationwide study, Von Hippel-Lindau disease mutation carriers and those at 50% risk were invited to complete a questionnaire assessing (compliance with) advice given for periodic surveillance. Medical record data on compliance with recommended radiologic surveillance examinations were also collected.Results: Of the 84 (77%) participants, 78 indicated having received advice to undergo periodic surveillance. Of these, 71 reported being fully compliant with that advice. In 64% of the cases, this advice was only partially consistent with published guidelines. Based on medical record data, between one quarter and one third of individuals did not undergo surveillance as recommended in the guidelines for central nervous system lesions and one half for visceral lesions. Screening delay for central nervous system lesions was significantly higher in one hospital and in those cases where “the advice given” deviated from the guidelines.Conclusions: The majority of those with or at risk of Von Hippel-Lindau disease reported having received and being fully compliant with screening advice. However, in many cases, the advice given was only partially consistent with published guidelines, and screening delays were observed. Efforts should be undertaken to stimulate guideline-based surveillance advice and to minimize screening delay.