Miracle-dz/UniFAR-FTUs huggingface dataset:
Paroxetine is an effective treatment for hot flashes: results from a prospective randomized clinical trial.

PURPOSE In an open-label trial we have previously demonstrated that paroxetine reduces hot flashes. We initiated a stratified, randomized, double-blind, cross-over, placebo-controlled trial to investigate the efficacy of paroxetine 10 mg and 20 mg compared to placebo in reducing hot flash frequency and composite score. A secondary objective was to evaluate quality of life (QOL) parameters. PATIENTS AND METHODS Women who suffered at least two hot flashes a day for 1 month or longer were eligible. Women were randomly assigned to 4 weeks of paroxetine 10 mg or 20 mg followed by placebo for 4 weeks, or placebo for 4 weeks followed by paroxetine 10 mg or 20 mg for 4 weeks. Participants completed baseline daily hot flash diaries for one week prior to the start of the study and throughout the study, and QOL questionnaires at baseline, week 5 and week 9. RESULTS 279 women were screened, and 151 were randomly assigned. Paroxetine 10 mg reduced hot flash frequency and composite score by 40.6% and 45.6%, respectively, compared to 13.7% and 13.7% for placebo (P = .0006 and P = .0008, respectively). Paroxetine 20 mg reduced hot flash frequency and composite score by 51.7% and 56.1%, respectively, compared with 26.6% and 28.8% for placebo (P = .002 and P = .004, respectively). Efficacy was similar between the two doses, but women were less likely to discontinue low-dose paroxetine. Paroxetine 10 mg was associated with a significant improvement in sleep compared with placebo (P = .01). CONCLUSION Paroxetine is an effective treatment for hot flashes in women with or without a prior breast cancer.
Procoagulant Activity of T Lymphoblastoid Cells in Extrinsic and Intrinsic Coagulation Systems

Summary We have measured the procoagulant activity (PCA) of four T lymphoblastoid cell lines (Jurkat, CEM, HSB-2 and Molt 4) as well as normal peripheral blood T lymphocytes, before and after stimulation with phytohaemagglutinin (PHA), using clotting and amidolytic methods. Of the four cell lines only one, Jurkat, gave enhanced PCA after stimulation with PH A. This activity was shown to be tissue factor-like by its dependence on factor VII in plasma and in an amidolytic assay with purified factors VII and X. Jurkat was also the only one of the four cell lines to secrete interleukin-2. All four cell lines promoted the generation of large amounts of thrombin in platelet-free plasma in glass tubes. This activity was dependent on the presence of plasma factor VIII, and was probably due to phospholipids in the cell membranes. Normal T lymphocytes gave intrinsic PCA in the thrombin generation test which was only 15% of that of the lymphoma cells. These results show that some T lymphocytes can develop PCA in both intrinsic and extrinsic systems and this should be taken into account in studies of the PCA of mixed leukocyte populations.
Customer orientations and usage of financial distribution channels

This research examined the survey responses of 801 financial customers who provided information regarding their usage of, and attitudes towards, financial distribution channels. The study found that there were distinctive segments within the financial market that had significantly different levels of usage of financial distribution channels. Financial customers were asked to indicate their orientation towards convenience, service, technology, computers, change, knowledge about methods of accessing money, and confidence in using electronic banking. Financial customers’ usage of human tellers, automated teller machines, electronic funds transfer at the point of sale, credit cards, cheques, Internet banking and telephone banking was investigated, and this information was used to determine if relationships exist between customer orientations and the usage of financial distribution channels. Further results and implications of the study for financial services are addressed.
Ownership Structure And Managerial Behavior To Beat Market Expectation In Korea

This paper examines whether firms ownership structure in Korea changes managers' behavior to meet or beat market expectations. We examine whether managers manage earnings upward and/or guide analyst expectations downward to avoid negative earnings surprises. By using companies listed on the Korean Stock Exchange, we find that the inclusion of a higher proportion of foreign ownership significantly increases the probability to meet or beat market expectations. The finding suggests that the firms with higher foreign ownership try to satisfy their foreign investors who emphasize current profits by boosting the stock price. We also find that managers are less likely to avoid negative earnings surprises as large shareholders ownership increases. The results imply that large shareholders play an internal monitoring role for managers' earnings and/or expectations management. In addition, firms with large shareholders ownership rely less on income-increasing discretionary accruals. Our findings supports the convergence-of-interest hypothesis that as the controlling shareholders ownership level increases, the interest of the controlling shareholder decreases managers opportunistic behavior to manage earnings.
Business Strategy Role as Mediation of Management Capability and Orientation of Entrepreneurship on Business Performance (A Study on Micro and Small Scale Seaweed Business in Takalar District, South Sulawesi Province)

This study aims to examine and analyze: (1) whether the business strategy is directly influenced by management ability, entrepreneurship orientation, (2) whether business performance is influenced by management ability, entrepreneurship orientation, both directly and indirectly, through business strategy as mediation. Theoretically, the results of this research is expected to be enrich and complete the repertoire of knowledge in strategic management field, especially micro and small entrepreneurship, so it can be useful for academics, practitioners and government. The population in this study is businessman. Respondents used as sample are 82 people seaweed entrepreneurs at micro and small scale based on Law No. 20 of 2008 in Takalar District South Sulawesi Province. The sampling method is census and an analytical method used in hypothesis testing is Path Analysis. The results of this study indicate that: (1) management capability indirectly affects on business strategy, (2) entrepreneurship orientation directly influences business strategy. (3) management capability directly affects business performance 4) entrepreneurship orientation indirectly affects on business performance but through business strategy as a mediating variable (5) business strategies directly affect the performance of the business. An important finding in this study shows that: the management ability and their respective business strategies directly affect the performance of the business, while management ability and entrepreneurship orientation indirectly affect on business performance but through business strategy.
Priming polyvalent immunity by DNA vaccines expressing chimeric antigens with a stress protein‐capturing, viral J‐domain

The N‐terminal domain of large tumor antigens (T‐Ag) of polyomaviruses forms a DnaJ‐like structure with a conserved J domain that associates with constitutively expressed stress protein heat shock protein (hsp)73. Mutant (but not wild‐type) SV40 T‐Ag show stable, ATP‐dependent binding to the stress protein hsp73 when expressed in cells from different vertebrate tissues. Intracellular T/hsp73 complexes accumulate to high steady‐state levels. From this observation, we designed a vector system that supports stable expression of a large variety of hsp73capturing, chimeric antigens containing an N‐terminal, T‐Ag‐derived domain, and different C‐terminal antigenic domains from unrelated antigens. Most antigenic domains tested could be stably expressed only in eukaryotic cells as fusion protein/hsp73 complexes. The N‐terminal 77 residues representing the J domain of T‐Ag were required for stable hsp73 binding and efficient expression of chimeric antigens. Hsp73‐bound chimeric antigens expressed by DNA vaccines showed strikingly enhanced immunogenicity evident in humoral (antibody) and cellular cytolytic T lymphocytes (CTL) responses. The described system supports efficient expression of chimeric, polyvalent antigens and their codelivery with hsp73 as a “natural adjuvant” for enhanced immunogenicity for T and B cells.
What really is alliance management capability and how does it impact alliance outcomes and success

Strategy scholars have asserted that a firm's alliance capability provides competitive advantage. As interest in alliance capability has grown, we see two streams of research emerge that address different, but equally important, issues related to this subject: one stream that focuses on how alliance capability develops in firms, and a second stream that investigates what elements specifically constitute a firm's alliance capability. In recent literature, the question of how firms develop alliance capability has received greater attention than the question of what elements actually comprise it; therefore, in this study we address the latter issue in great depth. We do this by building on prior research and on our fieldwork, to conceptualize alliance management capability as a multidimensional construct that comprises three distinct but related aspects or skills to address the following aspects in managing a given individual alliance after it is up and running: coordination, communication, and bonding. We then test our conceptualization in a framework that also links this capability to relevant outcomes at the alliance and firm level. We use survey and secondary data from a large sample of interfirm relationships between software service providers and three major global software vendors. We find general empirical support for our conceptualization of alliance management capability and for its predictive validity in impacting certain alliance outcomes. Copyright © 2009 John Wiley & Sons, Ltd.
Central Changes in Glaucoma: Neuroscientific Study Using Animal Models

Since long ago scientists have been trying hard to show up the core of glaucoma. To its understanding we needed to penetrate gradually to its molecular level. The newest pieces of knowledge about the molecular biology of glaucoma are presented in the first section. The second section deals with the clinical problems of glaucoma. Ophthalmologists and other medical staff may find here more important understandings for doing their work. What would our investigation be for, if not owing to the people’s benefit? The third section is full of new perspectives on glaucoma. After all, everybody believes and relies – more or less – on bits of hopes of a better future. Just let us engage in the mystery of glaucoma, to learn how to cure it even to prevent suffering from it. Each information in this book is an item of great importance as a precious stone behind which genuine, through and honest piece of work should be observed.
Comments on “Symmetric and Asymmetric Structures of Hurricane Boundary Layer in Coupled Atmosphere–Wave–Ocean Models and Observations”

Abstract : In a recent paper, Lee and Chen (2012, hereafter LC12) presented numerical simulations of symmetric and asymmetric hurricane boundary layer structures in a fully coupled atmosphere wave ocean model and used these simulations to compare aspects of the boundary layer structure against an analysis of observations. One of their main conclusions was that the azimuthally averaged inflow layer tends to misrepresent the overall inflow structure in tropical cyclones, especially the asymmetric structure (p. 3593). Another main conclusion was that the complicated asymmetric three-dimensional boundary layer structures (attributed by them to be) due in part to the air sea and wind wave coupling make it difficult to parameterize the atmosphere wave ocean coupling effects without a fully coupled model (p. 3593). After careful examination of their study, we have a number of questions regarding their methodology, their interpretations (including their interpretations of previous literature), and their conclusions. Specifically, we inquire about aspects of the methodology for defining the dynamical boundary layer depth, the selection of the boundary layer scheme, and we question the conclusions inferred. In addition to the foregoing concerns, inaccuracies in their literature review are noted and inconsistencies between their conclusions and reported results are identified. For many decades, physical processes across the air sea interface and within the atmospheric boundary layer have been known to be essential for the development and maintenance of a tropical cyclone (Ooyama 1969; Emanuel 1986, 1995; Smith et al. 2009; Smith and Montgomery 2010; Bryan and Rotunno 2009; Bryan 2012). However, the boundary layer is the least-observed part of a storm in particular, its turbulence structure. With the advent of the global positioning system (GPS) dropsonde (Hock and Franklin 1999), the mean boundary layer structure has been progressively studied.
The Co-Evolution of Strategic Alliances

This paper proposes a co-evolutionary theory of strategic alliances. The paper proposes a framework which views strategic alliances in the context of the adaptation choices of a firm. Strategic alliances, in this view, are embedded in a firm's strategic portfolio, and co-evolve with the firm's strategy, the institutional, organizational and competitive environment, and with management intent for the alliance. Specifically, we argue that alliance intent may be described, at any time, as having either exploitation or exploration objectives. We further discuss how the morphology of an alliance-absorptive capacity, control, and identification-may be isomorphic with its intent, and, in the aggregate, drive the evolution of the population of alliances.
Dielectric relaxation and transition of porous silicon

Dielectric impedance measurements of porous silicon within the frequency range of 50 Hz–1.0 MHz and temperature range of 298–798 K revealed three semicircles in a Cole–Cole plot when the temperature is raised to 773 K; they are thought to correspond to contributions from the grain interior, grain boundary, and electrode/film interface, respectively. The enhancement in conductivity by heating follows an Arrhenius law with an activation energy transition from 0.07 to 0.79 eV at ∼565 K, which originates from band tail hopping that occurs around the Fermi edge. At a critical temperature, a high degree of dispersion in the real and imaginary parts of the permittivity also occurs at low frequencies. This dispersion behavior is interpreted as a combination of electron-lattice polarization associated to the band tail hopping and the crystal field weakening due to thermal expansion.
Surface Anatomy of the Face in Down's Syndrome: Linear and Angular Measurements in the Craniofacial Regions

Measurements (23 projective linear, 2 angular) taken in the 6 craniofacial regions of 127 patients with Down's syndrome showed that 63.1% (1,836 of 2,908) were within normal limits and 36.9% (1,072) were outside them. Abnormal measurements were subnormal in 90.8% (973) and supernormal in 9.2% (99). All statistical summaries were based on z scores (adjusting for age and sex differences) classified into a small number of ranges to yield a simplified frequency distribution for each measurement. The purpose of the study was to identify the measurements closest to normal and those indicating the most severe degrees of sub-or supernormality. Approximately a quarter of normal measurements were classified as optimal, and half the subnormal or supernormal measurements were classified as severe. Intercanthal width had the highest frequency of optimal measurements (93.7%, 119 of 127), head circumference the smallest (28.6%, 36 of 126). Knowledge of the frequency of extreme abnormalities in the craniofacial regions will help during visual examination of patients with Down's syndrome. This study found the highest percentage of severely subnormal measurements in the orbital region (57.8%, 74 of 128) and the smallest in the labio-oral region (32.7%, 16 of 49). The measurement with the highest proportion of severely subnormal to all subnormal values was the palpebral fissure length (68%, 51 of 75), and the nose width had the smallest proportion (14.3%, 1 of 7).
Environmental Sustainability In The Thai Hotel Industry

Nowadays, the growing concern of environmental sustainability does not only influence consumers’ demand but also how companies run their own business. Consumers are more conscious about the environment and demanding environmental friendly products and services. Consequently, the tourism industry currently faces increasing demands from consumers to achieve levels of environmental responsiveness. Thus, companies strive to implement environmentally friendly and socially responsible practices to gain competitive advantage, while still maintaining commercial success. Moreover, empirical evidence indicated that companies’ increased environmental support results in the development of customer trust and commitment as well as higher profitability. Thus, this study attempts to investigate the antecedents of loyalty in the hotel industry by examining the impacts of attitude toward the hotel’s environmental concern, subjective norms, perceived value and destination competitiveness on customers’ future intentions. Also, the comparative examination of these relationships between high and low environmental concern groups was included. Results revealed that perceived value is, followed by destination competiveness, the most powerful predictor of future intentions in both high and low environmental concern groups. In addition, attitude towards the hotel’s environmental concern significantly influenced future intentions solely in high environmental concern group. Contrary to our expectation, subjective norms exerted no significant effect on future intentions in both groups.
Population genetics of Glossina morsitans submorsitans (Diptera: Glossinidae)

Abstract Breeding structure of Glossina morsitans submorsitans Newstead was evaluated by using genetic markers in mitochondrial DNA where diversity was scored at two loci in five natural populations from The Gambia and two populations in Ethiopia (form ugandensis Vanderplank), countries separated by c. 5450 km. Twenty six haplotype combinations were found, of which 17 were shared among two or more populations. Nine haplotypes were found in The Gambia and 23 haplotypes in Ethiopia. There were 12 unique haplotypes. Only six haplotypes were shared between the two countries. Populations in The Gambia (he = 0.26 ± 0.04) showed less than a third of the diversity of populations in Ethiopia (he= 0.84 ± 0.03). This suggests recovery from an earlier reduction in population. In a nested analysis of molecular variance of haplotype frequencies, 65%of the variance was due to differences within populations, 34% to differences between populations grouped by country, and only 1% was due to differences among populations within countries. In terms of gene flow, the fixation index FST= 0.35, which leads to an estimate by Wright’s island model of less than one reproducing migrant per generation exchanged between the eastern and western submorsitanspopulations. Nei’s genetic similarity measure showed a deep division between Gambian and Ethiopian populations.
Accounting Variables, Market Variables and Stock Return in Emerging Markets: Case of Iran

It is of great significance to identify the variables affecting stock return and its price in the emerging markets. According to CAPM, Beta (β) is the only variable capable of predicting the return. The recent studies demonstrate that there exist other variables which outperform stock return predictability potential of the Beta. Included among such variables are the size, debt-to-equity, book-to-market, earnings-to-price and sale-to-price ratios. The present research was aimed at testing the above variables and Beta for the prediction of stock return in order to recognize the variables which are better capable of predicting the stock return in Tehran Stock Exchange (TSE). Independent variables were tested against the dependant variable (return) on an annual basis for the years 1997- 2003. Further, multi-variable models were tested, both annually and pooled cross-sectionally. In single variable tests, a significant relationship was observed between the stock return and sale-to-price ratio, earnings-to-price ratio and size (stock market value) in 4 consecutive years. The book-to-market ratio demonstrated great dispersion in results. However, since the results of different years varied greatly, no stable relationship was observed between Beta and stock return as predicted in the CAPM model. Further, no relation was observed between debt-to-equity ratio and the stock return. Considering the potential effect of statistical models on the
The Purchasing of International Financial Services by Medium‐ and Large‐Sized UK Companies with European Subsidiaries

Reports a piece of empirical research that concentrates on just one segment of the corporate market – those companies, which have subsidiary companies in Europe. Says that these companies were chosen because they represent a rapidly growing market segment due to the increasing importance of European markets for UK industry. Highlights that the banks used in Europe for a subsidiary's financing were dependent on factors of chance or convenience. Concludes that banks will have to organise themselves more on traditional industrial lines, with divisions between salesmen, marketing, technical staff, personnel and general management, but in spite of 1970s difficulties the banking community is in a health condition.
Partner Nationality and the Structure-Performance Relationship in Strategic Alliances

The dramatic growth of global strategic alliances between firms is fundamentally reshaping the nature of international business, Indeed, interfirm cooperation has become a crucial component of the pursuit of global competitive advantage. Yet such alliances are enormously complex to manage successfully, in part because of the opportunity and incentive to cheat, and profit at the partner's expense, that is an inescapable part of these relationships. Consequently, strategic alliances are frequently subject to high instability, poor performance, and premature dissolution.Thus, an important question arises: Is it possible to promote more stable cooperation and higher alliance performance through a realignment of companies' incentives? This question is addressed empirically in the present paper using recent work in game theory, which suggests that high performance is linked to specific elements of the alliance structure. Further, this study applies insights from international business literature, suggesting that alliance partners from different countries are often characterized by sharp cultural, national, and organizational differences, to test this linkage in an international context.The study's data strongly support the hypothesis that alliance performance is linked to alliance structure. This finding has broad implications both for managers and management scholars, in suggesting that “up front” attention to alliance structure may help arrest the high failure rates, and improve alliance stability and performance levels. However, the data also support the hypothesis that the linkage between structure and performance varies by partner nationality. This finding points to the need for: (a) systematic assessment of salient characteristics of potential international partners; (b) development of programs to effectively deal with important differences between partner firms; and (c) attention to different key alliance structure dimensions, depending upon partner nationality. Finally, this study shows game theory to provide an extremely useful perspective in understanding crucial aspects of strategic alliances, although in the analysis of cross-border strategic alliances, the perspective must be enriched by an appreciation of interfirm diversity.