Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of Seprafilm bioresorbable membrane in adhesion prevention.

OBJECTIVE To evaluate, the safety and efficacy of Seprafilm, a novel bioresorbable membrane of chemically modified hyaluronic acid and carboxymethylcellulose, in preventing and reducing postoperative adhesion formation. DESIGN Randomized, controlled, blinded, prospective multicenter study. SETTING Major academic surgical centers. SUBJECTS 183 (treatment, n = 91; control, n = 92) patients with ulcerative colitis or familial polyposis. INTERVENTIONS Restorative proctocolectomy and ileal J-pouch anastomosis with diverting ileostomy followed by second-stage laparoscopy for ileostomy closure and direct visual assessment of the peritoneal cavity. Before abdominal closure in treated patients, Seprafilm, averaging 406.9 cm2 per patient, was applied without suturing between the midline incision and underlying tissues and organs. MAIN OUTCOME MEASURES Determination of the incidence, extent (mean percentage of midline incision associated with adhesions), severity (grade 1, least severe; grade 2, moderately severe; grade 3, very severe), and distribution of adhesions. RESULTS In 175 (treatment, n = 90) evaluable patients, Seprafilm significantly reduced the incidence (49% and 94%, respectively, p < 0.0001), extent (23% and 63%, respectively, p < 0.0001), and severity (15% versus 58% grade 3 severity, respectively, p < 0.0001) of postoperative adhesions. Seprafilm decreased the rate of adhesion formation by nearly 50%. More than half (51%) of Seprafilm recipients were adhesion-free, versus only 6% of untreated patients. Thus treated patients were eight times more likely to be free of adhesions than untreated controls. The incidence of incisional adhesions associated with the omentum, small bowel, left sidewall, bladder, ileostomy, and stomach was significantly reduced in the Seprafilm patients. Effects on vital signs and laboratory parameters were comparable in the two groups and were attributable to the operative procedure, concomitant therapy, or comorbid disease. All reported adverse events were associated with the surgical procedure and/or comorbid disease and did not differ significantly between the two groups (p > 0.05). CONCLUSION Seprafilm is safe and significantly reduces the incidence, extent, and severity of postoperative adhesions to the midline incision compared with no treatment, the current standard of surgical care.
Prediction of membrane protein types and subcellular locations

Membrane proteins are classified according to two different schemes. In scheme 1, they are discriminated among the following five types: (1) type I single‐pass transmembrane, (2) type II single‐pass transmembrane, (3) multipass transmembrane, (4) lipid chain‐anchored membrane, and (5) GPI‐anchored membrane proteins. In scheme 2, they are discriminated among the following nine locations: (1) chloroplast, (2) endoplasmic reticulum, (3) Golgi apparatus, (4) lysosome, (5) mitochondria, (6) nucleus, (7) peroxisome, (8) plasma, and (9) vacuole. An algorithm is formulated for predicting the type or location of a given membrane protein based on its amino acid composition. The overall rates of correct prediction thus obtained by both self‐consistency and jackknife tests, as well as by an independent dataset test, were around 76–81% for the classification of five types, and 66–70% for the classification of nine cellular locations. Furthermore, classification and prediction were also conducted between inner and outer membrane proteins; the corresponding rates thus obtained were 88–91%. These results imply that the types of membrane proteins, as well as their cellular locations and other attributes, are closely correlated with their amino acid composition. It is anticipated that the classification schemes and prediction algorithm can expedite the functionality determination of new proteins. The concept and method can be also useful in the prioritization of genes and proteins identified by genomics efforts as potential molecular targets for drug design. Proteins 1999;34:137–153. © 1999 Wiley‐Liss, Inc.
Skin toxicities and survival in advanced hepatocellular carcinoma patients treated with sorafenib

Aim: Sorafenib is the first small molecule with significant clinical activity for advanced hepatocellular carcinoma (HCC). However, intolerable adverse events are sometimes observed. On the other hand, it has been reported that some toxicities of molecular targeted drugs, such as skin toxicities and arterial hypertension, are correlated with good clinical outcomes in other cancers.
Review article: symptom improvement through eradication of Helicobacter pylori in patients with non‐ulcer dyspepsia

The aim of this article is to determine, by reviewing the literature, whether treatment of Helicobacter pylori infection in patients with non‐ulcer dyspepsia affects symptoms. Ten publications were identified through a computerized and manual literature search, and the percentage of patients with symptom improvement after successful or unsuccessful eradication therapy for H. pylori infection was calculated. In the 10 studies, symptom improvement after treatment was found in 73% of the patients that became H. pylori‐negative and 45% of the patients that remained H. pylori‐positive. Symptom improvement was modified by various clinical features and methodological aspects. If eradication of H. pylori failed, symptoms only improved over a short period. Symptom improvement was more pronounced in dyspeptic patients in whom H. pylori was eradicated than in those in whom H. pylori infection persisted.
Building Generalizable Agents with a Realistic and Rich 3D Environment

Towards bridging the gap between machine and human intelligence, it is of utmost importance to introduce environments that are visually realistic and rich in content. In such environments, one can evaluate and improve a crucial property of practical intelligent systems, namely \emph{generalization}. In this work, we build \emph{House3D}, a rich, extensible and efficient environment that contains 45,622 human-designed 3D scenes of houses, ranging from single-room studios to multi-storeyed houses, equipped with a diverse set of fully labeled 3D objects, textures and scene layouts, based on the SUNCG dataset (Song et al., 2017). With an emphasis on semantic-level generalization, we study the task of concept-driven navigation, \emph{RoomNav}, using a subset of houses in House3D. In RoomNav, an agent navigates towards a target specified by a semantic concept. To succeed, the agent learns to comprehend the scene it lives in by developing perception, understand the concept by mapping it to the correct semantics, and navigate to the target by obeying the underlying physical rules. We train RL agents with both continuous and discrete action spaces and show their ability to generalize in new unseen environments. In particular, we observe that (1) training is substantially harder on large house sets but results in better generalization, (2) using semantic signals (e.g., segmentation mask) boosts the generalization performance, and (3) gated networks on semantic input signal lead to improved training performance and generalization. We hope House3D, including the analysis of the RoomNav task, serves as a building block towards designing practical intelligent systems and we wish it to be broadly adopted by the community.
Is seroprevalence of anti-IGM CMV among blood donors relevant in India?

BACKGROUND Infection with cytomegalovirus (CMV) is more common in developing nations and the people belonging to the lower socioeconomic section of the society. The immunosuppressed population for whom CMV-seronegative blood products are requested is increasing due to advances in medical care. AIM To study the prevalence of CMV antibodies among the different sexes and age groups in healthy blood donors. MATERIALS AND METHODS A retrospective study was done on 5600 serum samples stored frozen in a repository for CMV antibodies using the ELISA technique. RESULTS Five thousand three hundred and fifty (95.5%) were male and 250 (4.5%) were female. Four cases (0.071%) out of 5600 samples were positive for anti-IgM CMV with 95% Confidence Interval (95% C.I) of 0.02 - 0.17. CONCLUSION In a developing country like India, screening for IgM antibody on a routine basis may not be feasible, given the likely positive yield to be low and the cost being high. It is recommended that in a tertiary care hospital, blood units to be transfused to neonates, organ transplant recipients, those suffering from malignancies and other immunocompromised patients should be screened for anti-IgM CMV or preventive strategies like universal leucodepletion to be implemented to decrease the transmission of CMV in these groups of patients.
Measuring quality of Life among Colorectal Cancer Patients in Jordan

Quality of life among colorectal cancer (CRC) patients was evaluated using the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ) C30 and EORTC QLQ-CR29. We interviewed 74 CRC patients, and our results indicated lower anxiety functional scores and higher abdominal pain and embarrassment symptom scores among patients aged 55 and under. Patients with disease metastasis showed significantly lower global health scores and higher fatigue, loss of appetite, hair loss, and change in taste symptom scores. Scores for emotional functioning were significantly lower among patients with stage IV disease. Fatigue, nausea and vomiting, loss of appetite, abdominal pain, and change in taste symptom scores were significantly higher in patients treated with a combination of surgery and chemotherapy compared to surgery alone. Age, disease metastasis, late disease stage, and combined treatment modalities were associated with lower scores on health-related quality-of-life scales; patients likely to have low scores on these measures should receive special attention from healthcare providers and be targeted by supportive care strategies. Nous avons évalué la qualité de vie de patients atteints du cancer colorectal à l'aide du Questionnaire C30 et EORTC QLQ-CR29 de l'Organisation européenne pour la recherche et le traitement du cancer. Nous avons interviewé 74 patients et nos résultats indiquent que les patients agés de 55 ans et moins éprouvent un moindre niveau d'anxiété alors que le niveau de douleurs abdominales et du sentiment de gêne est élevé. Les patients atteints de métastases ont démontré lors des tests que leur état général de santé était plutôt mauvais et qu'ils souffraient de fatigue accrue, de perte de cheveux et de la perte du goût L'état émotionel était à son plus bas chez les patients au stade IV de la maladie. La fatigue, la nausée, le vomissement, la perte d'appétit, les douleurs abdominales, et la perte de goût étaient significativement plus élevés chez les patients ayant été traités par chirurgie et chimiothérapie comparativement à ceux qui n'avaient subi que la chirurgie. L'âge, les métastases et le stade avancé de la maladie combinés à divers traitements médicaux sont les facteurs ayant contribué aux scores plus bas observés sur l'échelle de qualité de vie. Les patients susceptibles de démontrer de faibles résultats devraient recevoir une attention spéciale de la part des soignants et être la cible de soins de soutien appropriés à leur état.
5-GHz low phase noise CMOS LC-VCO with PGS inductor suitable for ultra-low power applications

A fully integrated LC-VCO fabricated in 0.13 µm CMOS technology is presented in this paper. The VCO achieves a wide tuning range of 31.43 % (from 3.841 GHz to 5.381 GHz). The measured phase noise is −120.63 dBc/Hz at 1 MHz offset from the carrier at 5.287 GHz. The current dissipation of the VCO is 1.32 mA from the 1.5 V power supply. The VCO figure of merit is greater than 190 placing this design among the top of the state-of-the-art.
Age-Related Social Desirability Responding Among Australian Women

THE FINDING by Ray (1988) that an overall correlation (r) of about . 3 among women but not among men existed between age and social desirability responding (i.e., presenting oneself in an unrealistically favorable light) was based on a range of adult general population surveys in several countries. Therefore, the finding must be regarded as one of the better established findings in social psychology. Ray, however, examined only the linear relationship between age and scores on a form of the scale by Crowne and Marlowe (1964). The possibilities of curvilinear relationships were not explored, and regrettably, the original data are no longer available to allow us to examine whether the relationship is constant across all age ranges. Large changes have been associated with the midlife crisis around age 40 (Sheehy, 1976), and they possibly account for the higher level of social desirability responding. The present study was designed to test this hypothesis. Senior sociology students at the University of New South Wales in Sydney, Australia, were asked to administer questionnaires to women whom they knew under the constraints (a) that no more than one person in three was to be educat-
Effects of low-level laser therapy on pain and scar formation after inguinal herniation surgery: a randomized controlled single-blind study.

OBJECTIVE The aim of this study was to investigate the efficacy of an infrared GaAlAs laser operating with a wavelength of 830 nm in the postsurgical scarring process after inguinal-hernia surgery. BACKGROUND Low-level laser therapy (LLLT) has been shown to be beneficial in the tissue-repair process, as previously demonstrated in tissue culture and animal experiments. However, there is lack of studies on the effects of LLLT on postsurgical scarring of incisions in humans using an infrared 830-nm GaAlAs laser. METHOD Twenty-eight patients who underwent surgery for inguinal hernias were randomly divided into an experimental group (G1) and a control group (G2). G1 received LLLT, with the first application performed 24 h after surgery and then on days 3, 5, and 7. The incisions were irradiated with an 830-nm diode laser operating with a continuous power output of 40 mW, a spot-size aperture of 0.08 cm(2) for 26 s, energy per point of 1.04 J, and an energy density of 13 J/cm(2). Ten points per scar were irradiated. Six months after surgery, both groups were reevaluated using the Vancouver Scar Scale (VSS), the Visual Analog Scale, and measurement of the scar thickness. RESULTS G1 showed significantly better results in the VSS totals (2.14 +/- 1.51) compared with G2 (4.85 +/- 1.87); in the thickness measurements (0.11 cm) compared with G2 (0.19 cm); and in the malleability (0.14) compared with G2 (1.07). The pain score was also around 50% higher in G2. CONCLUSION Infra-red LLLT (830 nm) applied after inguinal-hernia surgery was effective in preventing the formation of keloids. In addition, LLLT resulted in better scar appearance and quality 6 mo postsurgery.
Light microscopic morphometry of the kidneys of fourteen avian species.

Kidney volume and the volume proportions of the cortex, medulla, blood vessels larger than capillaries and ureter and ureteral ducts were investigated in 61 birds from 14 species representing passeriformes, psittaciformes, podicipediformes, anseriformes, galliformes, and columbiformes. The kidneys were fixed in situ by perfusion via their arterial supply. Kidney volume and body weight were strongly correlated (r = 0.991); the allometric function relating kidney volume (Vk) to body weight (W) was: Vk = 13.96W0. 902. Histological sections of one kidney from each bird were analysed by point counting with a Zeiss integrating eyepiece to estimate the volume proportions and subsequently the absolute volumes of the main components of the kidney. The avian kidney was found to consist of a very large cortex (range 71-81%), a relatively small medulla (range 5-15%), blood vessels larger than capillaries (range 10-13%). For all the birds, the mean volume proportions of the kidney components were as follows: cortex, 77%; medulla, 10%; blood vessels larger than capillaries, 12%; ureter and ureteral ducts, 1%. The values for the absolute volume of each of the main components of the kidney were well correlated with body weight. The allometric equations and correlation coefficients (r) relating: (a) the volume of cortex (Vc) and the body weight (W) was Vc = 10.06W0. 914, r = 0.991; (b) the volume of medulla (Vm) and body weight was Vm = 2.27W0. 795, r = 0.974; (c) the volume of blood vessels larger than capillaries (Vb) and body weight was Vb = 1.76W0. 894, r = 0.988. All the birds were divided into two groups in the following five sets: (a) passeriform and non-passeriform orders; (b) galliform and non-galliform orders; (c) small and large birds weighing less than and more than 500 g respectively; (d) aquatic and non-aquatic birds; (e) desert and non-desert birds. In the two groups of each set the differences between kidney volume per gram body weight and those between the respective percentage proportions of cortex, medulla and blood vessels larger than capillaries were assessed by Student's t-test. The differences between kidney volume per gram body weight were significant for all sets except desert and non-desert birds; those between the respective percentage proportions of cortex and medulla were significant for all sets; those between the percentage proportions of blood vessels larger than capillaries were significant only in desert and non-desert birds. (ABSTRACT TRUNCATED AT 400 WORDS)
Association of Atypical Decelerations With Acidemia

OBJECTIVE: To estimate the incidence of atypical fetal heart rate deceleration characteristics in term labor and their association with acidemia. METHODS: A 5-year retrospective cohort study was performed of all singleton, nonanomalous gestations delivered at 37 weeks or after. Thirty minutes of electronic fetal monitoring before delivery were interpreted by two formally trained research nurses, blind to clinical and outcome data, using American College of Obstetricians and Gynecologists (the College) guidelines as well as deceleration features historically referred to as atypica such as shoulders, slow return, and variability within the deceleration. Acidemia was defined as umbilical cord arterial pH 7.10 or less. Incidence of atypical features was estimated; univariable and multivariable analyses were performed. RESULTS: Within 5,388 women, the atypical feature seen with the most frequency was shoulders (n=2,914 [54.1%]) followed by slow return (n=2,618 [48.6%]), minimal deceleration variability (n=430 [8.0%]), and absent deceleration variability (n=4 [0.07%]). There was no difference in the incidence of atypical features between neonates with acidemia (n=57) and without (n=5,331). There was no association between shoulders (adjusted odds ratio [OR] 1.06, 95% confidence interval [CI] 0.63–1.81) or slow returns (adjusted OR 0.91, 95% CI 0.54–1.53) and acidemia. Similarly, compared with patients with moderate variability within deceleration nadirs, neither minimal (adjusted OR 0.82, 95% CI 0.43–1.55) nor marked (adjusted OR 0.65, 95% CI 0.27–1.55) variability was significantly associated with acidemia. CONCLUSION: These data support the absence of these specific atypical deceleration characteristics from the recognized definitions of decelerations stipulated by the College and the Eunice Kennedy Shriver National Institute of Child Health and Human Development in 2008 given their lack of association with acidemia or neonatal depression. LEVEL OF EVIDENCE: II
Genotypic characterization of Mycobacterium avium strains recovered from animals and their comparison to human strains

Mycobacterium avium was recovered from 21 birds and 10 pigs. Bird isolates carried IS901 and a few copies of IS1245 and appeared highly related by pulsed-field gel electrophoresis. Pig isolates showed features previously described in human isolates: a lack of IS901, a high copy number of IS1245, and marked polymorphism by pulsed-field gel electrophoresis.
Acute compartment syndrome of the thigh. A spectrum of injury.

Twenty-one compartment syndromes of the thigh in seventeen patients were identified for retrospective review. Ten of the compartment syndromes were associated with an ipsilateral femoral fracture; five of these femoral fractures were open. In five patients, the syndrome followed femoral intramedullary stabilization. The remaining eleven syndromes followed blunt trauma to the thigh, prolonged compression by body weight, or vascular injury. The patients who were awake and alert at the time of the examination complained of intense pain in the thigh, and they had neuromuscular deficits. For the patients who could not cooperate with a subjective physical examination because they were under general anesthesia or because of associated injuries, the measurement of compartment pressure assumed a more important diagnostic role. All of the patients had tense swelling of the involved thigh. The predisposing risk factors for the development of compartment syndromes of the thigh, which are common in the multiply injured population, include: systemic hypotension, a history of external compression of the thigh, the use of military antishock trousers, coagulopathy, vascular injury, and trauma to the thigh, with or without a fracture of the femur. In approximately one-half of these patients, a crush syndrome developed, with myoglobinuria, renal failure, and collapse of multiple organ systems. Eight patients (47 per cent) died as a result of multiple injuries. Of the nine patients (ten compartment syndromes) who survived, infection developed at the site of the fasciotomy in six. Follow-up examination revealed marked morbidity, including sensory deficit and motor weakness of the lower extremity. (ABSTRACT TRUNCATED AT 250 WORDS)
Evaluating Telepresence Experience and Game Players' Intention to Purchase Product Advertised in Advergame

In line with changes of consumers modern lifestyle has call for the advertising strategy to change. This research is to find out how game with telepresence and product experience embedded in the computer game to affect users’ intention to purchase. Game content developers are urging to consider of placing product message as part of game design strategy that can influence the game player’s intention to purchase. Experiment was carried out on two hundred and fifty undergraduate students who volunteered to participate in the Internet game playing activities. A factor analysis and correlation analysis was performed on items designed to measure telepresence, attitudes toward telepresence, and game player intention to purchase the product advertise in the game that respondents experienced. The results indicated that telepresence consist of interactive experience and product experience. The study also found that product experience is positively related to the game players’ intention to purchase. The significance of product experience implies the usefulness of an interactive advertising in the game playing to attract players’ intention to purchase the advertised product placed in the creative game design. Keywords—Purchase Intention, Telepresence, Product Experience, Interactive Experience