Miracle-dz/UniFAR-FTUs huggingface dataset:
Observations on the EB virus envelope and virus‐determined membrane antigen (MA) polypeptides

Experiments have been carried out to identify the polypeptide components of the Epstein‐Barr (EB) virusdetermined membrane antigen (MA) complex. Cells were radioiodinated using lactoperoxidase and the 125Ilabelled surface antigens, released by Triton X100, were analysed by sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS‐PAGE) after complexing either with human sera having anti‐MA activity or with a rabbit antiserum to EB virus. Using cells carrying EB virus isolated from four different conditions, including for the first time nasopharyngeal carcinoma (NPC), we have demonstrated four major polypeptides. One, with a molecular weight of 85,000, was remarkably constant irrespective of the cell line from which it came; two, with molecular weights varying from 240,000 to 270,000 and from 320,000 to 340,000, showed minor differences in mobility apparently depending on the species of origin of the cells (human or marmoset), rather than disparity between strains of virus. A fourth component, of 160,000 daltons, was found on only two of the cell lines studied. In addition, it has been shown for the first time that the same polypeptides composing the MA complex are present on the viral envelope itself. The fact that the rabbit antiserum to EB virus recognized only the two highest molecular weight MA components, yet showed virus‐neutralizing activity, indicates the importance of these two polypeptides for use in a vaccine designed to induce virus‐neutralizing antibodies.
Clustering Time Series by Network Community Analysis

Community analysis, a recently developed approach for partitioning the nodes of a network, is used as a tool for time series clustering. A network with N nodes is associated to the set of N time series, with the weight of the link (i,j) quantifying the similarity between the two corresponding time series. Then, searching for network communities allows one to identify groups of nodes (i.e., time series) with strong similarity. A quantitative assessment of the significance of the obtained partition is also provided.
Inhibition of Molecular Signaling in Huh-7 Cells by AM3: A Novel Chemotherapeutic Agent for Hepatocellular Carcinoma.

BACKGROUND According to a review of recent literature, no previous studies have reported the dose-dependent selective inhibition of the antiproliferative activity using colony and sphere formation assays and immunoblotting in human hepatoma cells in response to doxorubicin and mitoxantrone structural analogs such as AM3. OBJECTIVE We evaluated the anticancer activity of mitoxantrone (MIT) structural analogs 1,5-bis({2- [(2-hydroxyethyl) amino]ethyl}-amino)-anthracene-9,10-dione (AM3) in human hepatoma cells (Huh-7). METHODS In this paper, we synthesized AM3 through the nucleophilic amino substitution of 1,5- dichloroanthraquinone with the corresponding dichloride groups under microwave-accelerated heating. The structural characteristics of AM3 were analyzed through ultraviolet-visible spectroscopy and nuclear magnetic resonance. In vitro activity of AM3 was measured using the dose-dependent selective inhibition of the antiproliferative activity using colony and sphere formation assays and immunoblotting in Huh-7. RESULTS The antiproliferative activity of AM3 was determined using IC50 values as 2.03 and 1.70 µM for hepatocellular carcinoma cell lines Huh-7 and SK-Hep-1 cells, respectively. In addition, colony formation assay of Huh-7 cells revealed that AM3 significantly suppressed the mean colony formation rate from 99.9 % to 2.5 %, and growth inhibition rate of sphere cells was significant, in which 5.0 µM of AM3 inhibited up to 28.5 % cell growth in the Huh-7 sphere cells. Immunoblotting confirmed the overexpression of CD44, COX-2, p-Akt, and Akt. CONCLUSION Thus, AM3 is a novel therapeutic agent for suppressing cancer stemness and inflammation signaling in Huh-7 cells.
Personality Qualities of Successful Business Leaders in Ghana

The gap which the current qualitative, phenomenological study sought to fill was to explore the critical personality characteristics top business executives need to possess to be able to lead corporate organizations more effectively. Data were obtained through email and face-to-face in-depth semi-structured interviews with 10 CEOs of the best performing public and private business companies (known as Ghana Club 100) in Ghana. The interview data were transcribed verbatim and analyzed employing transcendental phenomenological analysis (Moustakas, 1994). The following personality attributes emerged from the participants’ interviews which were found to support and promote strong executive effectiveness: self-discipline, passion, self-confidence, integrity, openness to experience, adaptability, humility, emotional intelligence and maturity, big-picture orientation, and commitment to the growth of organizational members. Such knowledge could help to inform Board of Directors of Corporations in the selection, promotion, and training of executive-level managers, and potentially lower the costs associated with losing high-potential executive leaders. The findings of the present study could also help business schools, organizational psychologists and management consultants to focus better on preparing business leaders for the future. The current study is one of the first to be carried out in Ghana on leader personality traits. Keywords: leadership personality qualities, effective business leadership characteristics, leadership development
P2Y12 receptors in primary microglia activate nuclear factor of activated T‐cell signaling to induce C–C chemokine 3 expression

Microglia are widely accepted as surveillants in the central nervous system that are continually searching the local environment for signs of injury. Following an inflammatory situation, microglia alter their morphology, extend ramified processes, and undergo cell body hypertrophy. Extracellular nucleotides are recognized as a danger signal by microglia. ADP acting on P2Y12 receptors induce process extension of microglia thereby attracting microglia to the site of adenosine tri‐phosphate/ADP leaking or release. However, the question whether ADP/P2Y12 receptor signaling directly stimulates the production or release of inducible factors such as cytokines remains unclear. In this study, we found that CC chemokine ligand 3 (CCL3) is induced by ADP‐treated primary microglia. Pharmacological characterization using pertussis toxin, a P2Y12 receptor inhibitor, and a calcium chelator revealed that CCL3 induction was caused by P2Y12 receptor‐mediated intracellular calcium elevation. Next, nuclear factor of activated T‐cell dephosphorylation and nuclear translocalization were observed. Calcineurin, an inhibitor for nuclear factor of activated T cell, suppressed CCL3 induction. These data indicate that microglial P2Y12 receptors are utilized to trigger an acute inflammatory response in microglia via rapid CCL3 induction after ADP stimulation.
Student and Employer Evaluation of Hiring Criteria for Entry-Level Marketing Positions

Marketing education has many facets, including recruiting students as marketing majors, educating students in marketing concepts and applications, and placing marketing graduates in the business world. This study reports the results of a survey which investigated student and employer evaluations of potential hiring criteria for entry-level marketing positions. Suggestions of how marketing educators can use the results to help their marketing graduates also are discussed.
The economics of the UK aerospace industry : a transaction cost analysis of defence and civilian firms

The primary aim of this thesis is to assess vertical integration in the UK aerospace industry with a transaction cost approach. There is an extensive theoretical and conceptual literature on transaction costs, but a relative lack of empirical work. This thesis applies transaction cost economics to the UK aerospace industry focusing on the paradigm problem of the make-or-buy decision and related contract design. It assesses whether the transaction cost approach is supported (or rejected) by evidence from an original survey of the UK aerospace industry. The central hypothesis is that UK aerospace firms are likely to make components inhouse due to higher levels of asset specificity, uncertainty, complexity, frequency and small numbers, which is reflected in contract design. The thesis makes these concepts operational. The empirical methodology of the thesis is based on questionnaire survey data and econometric tests using Ordinary Least Squares (OLS) and logit regressions to analyse the make-or-buy decision and the choice of contract type. The results from this thesis find limited evidence in support of the transaction cost approach applied to the UK aerospace industry, in spite of a bespoke dataset. The empirical tests of vertical integration for both make-or-buy and contract type as the dependent variable yield insufficient evidence to conclude that the transaction cost approach is an appropriate framework for analysing the UK aerospace industry as applied in this thesis.
Network Ethnography

A general interest in the study of social practices has been spreading across a diversity of disciplines in organization and management research, relying mostly on rich ethnographic accounts of units or teams. What is often called the practice-turn, however, has not reached research on interorganizational networks. This is mainly due to methodological issues that call, in the end, for a mixed-method approach. This article addresses this issue by proposing a research design that balances well-established social network analysis with a set of techniques of organizational ethnography that fit with the specifics of interorganizational networks. In what we call network ethnography, qualitative and quantitative data are collected and analyzed in a parallel fashion. Ultimately, the design implies convergence during data interpretation, hereby offering platforms of reflection for each method toward new data collection and analysis. We discuss implications for mixed-method literature, research on interorganizational networks, and organizational ethnography.
Merging Professional Service Firms

The prevailing theory of mergers is that firms emphasize considerations of “strategic fit” in discussions prior to merger activity, and neglect considerations of “organizational fit”. The result is that immediately following a merger dysfunctional organizational behaviours occur. The number of empirical studies of mergers, however, is relatively modest and there are few case studies of the merger process. The present paper studies the merger involving two large accounting firms, over a period of four years. The unique features of accounting firms—in particular, their organization as professional partnerships—and of the accounting industry, make the case study an appropriate “tough” test of the general theory. Accounting firms are likely to take account of organizational fit in merger discussions.The case study rehearses the careful attention to issues of strategic and organizational fit (contrary to the general theory) but also maps the unfolding behavioural problems that followed formal merger. Interestingly, the specific difficulties observed in previous studies were less salient in the present case: problems and difficulties were of a kind peculiar to the type of organization, which suggests that theories of mergers should be sensitive to the context and setting of merger activity.The paper concludes by elaborating elements of a more systematic model of the merger process. These elements include the difference between mergers and acquisitions, the structure of governance, organizational capacity, sector cohesiveness and technology.
Evaluating the causes of uncertainty in logistics operations

Purpose – The purpose of this paper is to verify a transport uncertainty triad model taking a supply chain perspective, and determine which different forms of uncertainty impact on transport operations. The aim is to qualitatively evaluate the different types of uncertainty impacting on transport operations rather than estimating the risk that each of them involved. The literature indicates that there are many factors that influence transport operations. This paper aims to determine the key factors that impinge practice. Design/methodology/approach – On the basis of a literature review, a conceptual model was developed to categorise the different factors that impact on transport operations. In order to determine the credibility of this model and assess which factors are the main barriers to effective transport operations a series of focus groups involving UK logistics practitioners and policy makers was undertaken. Findings – The findings indicate that the main drivers impacting on transport operations are delays, delivery constraints, lack of coordination, and variable demand/poor information. The consequence of these is to reduce the efficiency of transport operations. Also, in the overall focus groups' data, unplanned road congestion represents the biggest individual issue leading to uncertainty. Research limitations/implications – The model is refined based only on participants' perceptions. Therefore, further empirical-based research is needed to quantitatively validate it, for each cluster identifying the frequency with which it occurs and the impact on economic and environmental performance. This will further strengthen understanding of the main uncertainty causes within supply chains in the UK. The model should also be tested through the investigation of real-world situations, measuring the marginal impact of logistics disruptions, in economic and environmental terms. Practical implications – The paper highlights the importance of looking at the whole of the logistics triad when dealing with uncertainty, as often there are multiple sources involving the shipper, carrier and customer. Equally, the paper highlights the importance of external factors, and managers need to consider how to deal with these issues. Although the easiest approach is to accommodate them within operational plans, there is scope for engaging with policy makers to identify ways forward. Originality/value – Many researchers have developed supply chain uncertainty models focusing mainly on manufacturing. Transport has traditionally been considered as a marginal activity within supply chains and it has not been explicitly taken into account in those frameworks. It is necessary to determine the forms of supply chain uncertainty that exist and their impact on transport operations, as they will define the performance of logistics operations.
Sex Difference in Homicide: Comparing Male and Female Violent Crimes in Korea

The comparison of the South Korean male and female homicide offenders’ characteristics and crime scene behaviours is presented in this study. A total of 537 cases of homicide offenders prosecuted in Korea between 2006 and 2010 were analyzed in terms of offenders’ characteristics, victim–offender interaction, places of crime, and crime scene actions. Significant differences between male and female offenders were revealed in prior criminal history, offenders’ personal characteristics, choice of victim, crime scene behaviours during and after the homicide, and choice of weapon. The parallel with the gender differences in homicides found in Western countries is discussed as well as the possible explanations for the gender-related characteristics found in this study.
A linear cascade near-ballistic uni-traveling-carrier photodiodes with extremely high saturation-current bandwidth product (6825mA-GHz, 75mA/91GHz) under a 50Ω load

We demonstrate linear cascade near-ballistic uni-traveling-carrier photodiodes. Compared with control (a single device), this novel structure exhibits significant improvement in bandwidth-efficiency and saturation-current-bandwidth products. Record-high saturation-current-bandwidth product ( > 6825 mA-GHz, 91GHz) under 50Ω loads can be achieved.
Modelling e‐service quality and its consequences in India: an SEM approach

Purpose – The purpose of this paper is to empirically test a research model of consumer consequences of e‐service quality (e‐SQ) perceptions of general web site users.Design/methodology/approach – The dimensions of e‐SQ are extracted and validated through exploratory and confirmatory factor analysis. The uni‐dimensional model of e‐SQ, consisting of web site attributes of ease of access, flexibility, and reliability, is then tested by structural equation modelling using AMOS 4.0 for its linkages with e‐satisfaction (e‐SAT), perceived value, and e‐loyalty‐linked behavioral intentions, i.e. repurchase and recommendation intentions.Findings – It was found that e‐SQ is a direct antecedent of perceived value, perceived value in turn significantly affects e‐loyalty‐related consumer intentions of repurchase and positive recommendations. e‐SAT is a direct antecedent of positive recommendation intentions. However, e‐SQ was not found to have any consequential relationship with e‐SAT or direct links with behavioral i.
Reliability and Validity of the Turkish Version of the Addiction Severity Index in Male Alcohol Dependents.

INTRODUCTION We aimed to evaluate the psychometric characteristics of the Turkish translation of the Addiction Severity Index (ASI) in 115 male alcohol-dependent patients. METHOD The reliability of the instrument was assessed by measuring test-retest, interrater and internal reliabilities. In the validity analysis, the correlation coefficients between corresponding severity ratings and composite scores of each subscale and concurrent validity were assessed. Moreover, the discriminant validity and concurrent validity scores were calculated. RESULTS The test-retest reliability of the ASI scores ranged from . 79 to . 91. The interrater reliability assigned by three raters was high (.74 to .99). Cronbach's alpha coefficient for internal consistency was . 85 for all scales, and it varied between . 64 and . 77 for the subscales. The Beck Depression Inventory moderately correlated with the Psychatric status, and the MacAndrew Alcoholism Scale correlated with the Alcohol and Drug Use subscales of the Addiction Severity Index (ASI). The correlation coefficient was . 91 for the alcohol use subscale. CONCLUSION The results obtained in this study suggest that the Turkish version of the ASI could be used as a reliable and valid instrument in alcohol-dependent patients.
Technological Activities and Their Impact on the Financial Performance of the Firm: Exploitation and Exploration within and between Firms

This paper analyzes the consequences for financial performance of technology strategies categorized along two dimensions: (1) explorative versus exploitative and (2) solitary versus collaborative. The financial performance implications of firms’ positioning along these two dimensions has important managerial implications, but has received only limited attention in prior studies. Drawing on organizational learning theory and technology alliances literature, a set of hypotheses on the performance implications of firms’ technology strategies are derived. These hypotheses are tested empirically on a panel dataset (1996-2003) of 168 R&D-intensive firms based in Japan, the US and Europe and situated in five different industries (chemicals, pharmaceuticals, ICT, electronics, non-electrical machinery). Patent data are used to construct indicators of explorative versus exploitative technological activities (activities in new or existing technology domains) and collaborative versus solitary technological activities (joint versus single patent ownership). The financial performance of firms is measured via a market value indicator: Tobin’s Q index.
Associação entre a capacidade funcional de idosos dependentes e a sobrecarga do cuidador familiar

A investigacao objetivou caracterizar os idosos dependentes e seus cuidadores familiares principais e verificar a associacao entre a capacidade funcional do idoso e a sobrecarga do cuidador. Estudo transversal com 112 idosos/cuidadores vinculados a uma unidade basica de Porto Alegre. Instrumento com variaveis socioeconomicas, relacionadas ao cuidadoe escalas de Atividades Fisicas e Instrumentais de Vida Diaria (AFVDs e AIVDs) eBurden Interview foram aplicados.Utilizou-se teste de Correlacao de Spearman. A media de idade dos idosos foi de 81,41 anos, o escore medio para as AFVDs foi 10,36 e6,25 para AIVDs. Dos 112 idosos, 71,4% possuiam dependencia grave. Dos cuidadores, 75% eram mulheres, 61,6%, filhos, com media de idade de 57,98 anos e de sobrecarga de 29,53, equivalente a sobrecarga moderada. Houve correlacao significativa entre a capacidade funcional dos idosos e a sobrecarga do cuidador. Verificou-se que, quanto maior a dependencia do idoso, maior a sobrecarga do cuidador.
Links Between Swiss Hotel Guests' Product Involvement and Brand Loyalty

Involvement has been studied for 30 years, but how product involvement is linked to brand loyalty in four- or five-star leisure hotels needs further examination. This study examines how Swiss leisure travelers' product involvement with a hotel relates to loyalty to the hotel brand. Findings demonstrate moderately high involvement levels yet weaker brand loyalty impacted by the tourist's desire to visit different destinations. Involvement antecedents “pleasure” and “sign value” show strong relationships, suggesting that tailored marketing strategies are needed to enhance involvement. Some potential involvement-enhancing strategies are discussed in the conclusions to the study.
The evolution of self-regulation in food advertising

The FTC envisions the Children’s Advertising Review Unit (CARU) and the Children’s Food and Beverage Advertising Initiative playing lead roles in self-regulatory efforts to address advertising’s contribution to childhood obesity. Peeler (2009) notes that CARU’s decisions provide comprehensive guidance to advertisers. Limited research has investigated those decisions. Using thematic analysis, this study examines CARU case reports from 2000 to 2010 involving food marketers from a longitudinal perspective. This study found that CARU has been responsive to the emergence of childhood obesity as evidenced in its increased pursuit of nutrition-related complaints, case language and Guidelines revisions. Suggestions for strengthening CARU, the CFBAI and media clearance are offered.
Comparison of low-molecular-weight-heparin and unfractionated heparin for acute PTE

Objective: Acute pulmonary thromboembolism (PTE) is a serious high mortality pulmonary vascular disease whose effective treatment decreases morbidity and mortality. To determine if low-molecular-weight-heparin (LMWH) is clinically as efficient and safe as unfractionated heparin (UH) in patients with diagnosis of acute non-massive PTE, our study compares the efficacy, adverse effects and costs of LMWH and UH. Methods: One hundred and fourteen patients with non-massive acute PTE were randomly divided into LMWH (nadroparin calcium) and UH groups. Oxygenation index, D-dimer, fibrinogen (FG), lung ventilation/perfusion (V/Q) scan and computed tomography pulmonary angiography (CTPA) were observed before anticoagulation and on day 14 after anticoagulation. Results: In both groups, the ABG (arterial blood gas) analysis showed PaO2 and PaCO2 were elevated, P(A-a)O2 was decreased and oxygenation index (PaO2/FIO2) was elevated, D-dimer and fibrinogen were decreased, lung V/Q and CTPA showed embolized segments reduced (P<0.05). Hemorrhage and thrombocytopenia occurred in 3.5% of the LMWH group. Hemorrhage occurred in 5.3% and thrombocytopenia occurred in 7.0% of the UH group. The average cost in the LMWH group was RMB 1218.60 Yuan and RMB 1541.40 Yuan in the UH group. Conclusion: LMWH and UH are equally effective for treatment of non-massive acute PTE, but LMWH may have a lower prevalence of complications and is less expensive.