Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Team Learning Behaviors on Team Innovative Work Behavior

The aim of this review was to get insight into the impact of learning behaviors on innovative behavior in work teams. We addressed this issue by carrying out a systematic literature review. Thirty-one articles that reported studies on learning and innovation development in work teams were included in the review. By integrating the correlational findings of the original studies, we found that, at large, all investigated team learning behaviors had an effect on aspects of team innovative work behavior. Concerning specific team learning behaviors, sharing, team reflection, and team activity had the strongest impact on teams’ engagement in innovation development. A central conclusion is that learning and innovation development are mutually dependent aspects of teamwork and that fostering one aspect will also be beneficial for the other. Based on our findings, we draw practical implications for fostering team development through enhancing learning behaviors and innovative work behavior in teams.
Stretch‐activated anion currents of rabbit cardiac myocytes.

1. Stretch‐activated anion currents were studied in sino‐atrial and atrial cells using the whole‐cell patch clamp technique. With continuous application of positive pressure (5‐15 cmH2O) through the patch clamp electrode, the cell was inflated and the membrane conductance was increased. 2. Voltage clamp steps revealed that the stretch‐activated currents had time‐independent characteristics. The increase in membrane conductance was reversible on subsequent application of negative pressure to the electrode. 3. The reversal potential of the stretch‐activated currents was shifted by 60 mV for a 10‐fold change in intracellular Cl‐ concentration, while it was unaffected by replacement of Na+ in the extracellular solution by N‐methyl‐D‐glucamine. Cell superfusion with Cl(‐)‐deficient solution (10 mM Cl‐) reduced the amplitude of outward current. These findings indicate that the stretch‐activated conductance is Cl‐ selective. 4. The sequence of anion permeability through the stretch‐activated conductance was determined to be I‐(1.7) > NO3‐(1.5) > Br‐(1.2) > Cl‐(1.0) > and F‐(0.6). SCN‐ appeared to be more permeant than I‐. 5. The stretch‐activated conductance was reduced by the Cl‐ channel blockers, 4,4'‐dinitrostilbene‐2,2'‐disulphonic acid disodium salt, 4‐acetamido‐4'‐isothiocyanatostilbene‐2,2'‐disulphonic acid or anthracene‐9‐carboxylate (9‐AC). Administration of furosemide or bumetanide had no effect. 6. The stretch‐activated Cl‐ current was recorded even though intracellular Ca2+ ions were chelated by including 10 mM EGTA in the pipette solution. Neither the specific peptide inhibitor of cyclic AMP‐dependent protein kinase (50 microM), nor the non‐selective blocker of protein kinases, H‐7 (20 microM), was effective in reducing the stretch‐activated Cl‐ current, suggesting that the stretch‐activated Cl‐ current is a novel type of cardiac Cl‐ current, which shows a different modulatory mechanism from that of other cardiac Cl‐ currents.
Effect of elevated total cholesterol level and hypertension on the risk of fatal cardiovascular disease: a cohort study of Chinese steelworkers.

BACKGROUND Increased blood pressure and elevated total cholesterol (TC) level are the two most important modifiable risk factors of cardiovascular disease (CVD) in the world. Hypertension and hypercholesterolemia co-exist more often than would be expected and whether there is a synergistic impact on fatal CVD between elevated TC and hypertension need to be further examined in Chinese population. METHODS We conducted a cohort study which recruited 5092 Chinese male steelworkers aged 18 - 74 years in 1974 - 1980 and followed up for an average of 20.84 years. Totally 302 fatal CVD events were documented by the year of 2001. Cox proportional hazards regression models were undertaken to adjust for baseline variables with fatal CVD events as the outcome variable. Additive interaction model was used to evaluate the interaction between elevated TC and hypertension. RESULTS Hypercholesterolemia and hypertension were significantly associated with an increased hazard ratio (HR) of fatal CVD (1.67 (95%CI 1.18 - 2.38) and 2.91 (95%CI 2.23 - 3.80) respectively. Compared to participants with normotension and TC < 240 mg/dl, the HRs were 1.11 (95%CI 0.56 - 2.21), 2.74 (95%CI 2.07 - 3.64) for hypercholesterolemia and hypertension respectively, and 5.51 (95%CI 3.58 - 8.46) for participants with both risk factors. There was an additive interaction with a 2.65 (95%CI 0.45 - 4.85) relative excess risk (RERI) between hypercholesterolemia and hypertension on CVD. CONCLUSION We found that the risk of fatal CVD was significantly associated with an additive interaction due to hypercholesterolemia and hypertension besides a conventional main effect derived from either of them, which highlights that the prevention and treatment of both risk factors might improve the individual risk profile thus reduce the CVD mortality.
The preventative power of “pink”: Delineating the effects of social identification and protection motivation theory in breast cancer-related advertisements

ABSTRACT An online experiment was conducted to assess the extent gender-salient breast cancer awareness advertisements had on influencing risk perception, encouraging preventative behaviors, and gathering health information. Social identification theory and protection motivation theory postulate gender-salient pink-branded advertisements trigger defense mechanisms, countering desired outcomes. This study concludes gender-salient ads focusing on women, and displaying the Susan G. Komen logo caused aversive behaviors, whereas gender-neutral ads, showing medical providers and logos such as American Medical Association, improve health-related reporting. Results also highlight a disconnect between women who socially identify as breast cancer survivors/supporters, and those with no prior experience with breast cancer.
JC Virus Latency in the Brain and Extraneural Organs of Patients with and without Progressive Multifocal Leukoencephalopathy

ABSTRACT JC virus (JCV) is latent in the kidneys and lymphoid organs of healthy individuals, and its reactivation in the context of immunosuppression may lead to progressive multifocal leukoencephalopathy (PML). Whether JCV is present in the brains or other organs of healthy people and in immunosuppressed patients without PML has been a matter of debate. We detected JCV large T DNA by quantitative PCR of archival brain samples of 9/24 (38%) HIV-positive PML patients, 5/18 (28%) HIV-positive individuals, and 5/19 (26%) HIV-negative individuals. In the same samples, we detected JCV regulatory region DNA by nested PCR in 6/19 (32%) HIV-positive PML patients, 2/11 (18%) HIV-positive individuals, and 3/17 (18%) HIV-negative individuals. In addition, JCV DNA was detected in some spleen, lymph node, bone, and kidney samples from the same groups. In situ hybridization data confirmed the presence of JCV DNA in the brains of patients without PML. However, JCV proteins (VP1 or T antigen) were detected mainly in the brains of 23/24 HIV-positive PML patients, in only a few kidney samples of HIV-positive patients, with or without PML, and rarely in the bones of HIV-positive patients with PML. JCV proteins were not detected in the spleen or lymph nodes in any study group. Furthermore, analysis of the JCV regulatory region sequences showed both rearranged and archetype forms in brain and extraneural organs in all three study groups. Regulatory regions contained increased variations of rearrangements correlating with immunosuppression. These results provide evidence of JCV latency in the brain prior to severe immunosuppression and suggest new paradigms in JCV latency, compartmentalization, and reactivation.
Vitamin D intoxication with severe hypercalcemia due to manufacturing and labeling errors of two dietary supplements made in the United States.

CONTEXT More than 50% of Americans use dietary supplements, and 60-70% fail to report this use to their physicians. Intoxication from vitamin D supplements has been rarely reported but may now occur more frequently. This may be attributable to an increase in vitamin D supplement intake due to the findings that deficiency is common and has been associated with a number of disease states. OBJECTIVE We report two cases of vitamin D intoxication with dietary supplements made in the United States caused by manufacturing and labeling errors. METHODS Case histories were obtained, and serial laboratory data (calcium and vitamin D metabolites) were measured. Each dietary supplement was analyzed by UV spectrophotometry followed by HPLC. RESULTS In both cases, repetitive inquiries were required to elicit the use of dietary supplements. Because of significant manufacturer errors and a labeling error, patients had been consuming more than 1000 times the recommended daily dose of vitamin D(3). Hypercalcemia is directly proportional to serum 25-hydroxyvitamin D [25(OH)D] but not 1,25-dihydroxyvitamin D levels. It took approximately 1 yr to normalize 25(OH)D levels. However, once 25(OH)D levels decreased below 400 ng/ml, both patients became normocalcemic and asymptomatic without long-term sequelae. CONCLUSIONS Although rare, vitamin D intoxication should be considered in the differential diagnosis of hypercalcemia. Patients should be asked whether they are using dietary supplements, and serial questioning may be required because patients may not consider these supplements to be potential health risks. Errors in the manufacturing and labeling of dietary supplements made in the United States may place individuals at increased risks for side effects.
Tonometry in Corneal Edema after Cataract Surgery: Rebound versus Goldmann Applanation Tonometry

Abstract Purpose: Goldmann applanation tonometry (GAT) is known to be influenced by corneal properties, whereas the effect of corneal edema on intraocular pressure (IOP) measurement using Rebound tonometry (RT) is not clear. In this study, IOP was measured before and after cataract surgery using GAT and RT to investigate differences between methods and the effect of postsurgical corneal edema. Methods: Thirty patients with cataract were included in a prospective study. IOP was measured using GAT and RT (Icare PRO, Tiolat Oy, Finland) before and after one day of phacoemulsification. Central corneal thickness (CCT) was determined before and after surgery (Pentacam, Oculus, Germany). Results: CCT increased significantly after surgery by 52.2 ± 35.1 µm (p < 0.0001). IOP values of GAT and RT were significantly correlated before surgery (r = 0.65, p < 0.0001) and after surgery (r = 0.94, p < 0.0001). No significant correlation of GAT and RT to CCT before surgery (GAT: r = 0.18, p = 0.36; RT: r = 0.03, p = 0.87) or after surgery (GAT: r = −0.08, p = 0.69; RT: r = 0.17, p = 0.37) was found. The mean difference between GAT and RT (GAT-RT) was −1.0 ± 2.9 mmHg (range −6.2 to 6.4 mmHg, p = 0.08) before surgery and −1.1 ± 2.2 mmHg (range −5.1 to 4.8 mmHg, p = 0.01) after surgery. Before surgery, a positive correlation of GAT-RT with mean IOP of both methods is apparent (r = 0.45, p = 0.01). After surgery, no such correlation was found (r = −0.08, p = 0.69). Conclusions: RT underestimates IOP in higher values and overestimates IOP in lower values compared to GAT before surgery. This is not apparent in eyes with corneal edema. Large differences between methods may be present in individual patients with and without corneal edema.
Joint User Activity and Data Detection Based on Structured Compressive Sensing for NOMA

Non-orthogonal multiple access (NOMA) has been regarded as one of the promising key technologies for future 5G systems. In the uplink grant-free NOMA schemes, dynamic scheduling is not required, which can significantly reduce the signaling overhead and transmission latency. However, user activity has to be detected in grant-free NOMA systems, which is challenging in practice. In this letter, by exploiting the inherent structured sparsity of user activity naturally existing in NOMA systems, we propose a low-complexity multi-user detector based on structured compressive sensing to realize joint user activity and data detection. In particular, we propose a structured iterative support detection algorithm by exploiting such structured sparsity, which is able to jointly detect user activity and transmitted data in several continuous time slots. Simulation results show that the proposed scheme can achieve better performance than conventional solutions.
A new method for isolating tyrosine kinase substrates used to identify Fish, an SH3 and PX domain‐containing protein, and Src substrate

We describe a method for identifying tyrosine kinase substrates using anti‐phosphotyrosine antibodies to screen tyrosine‐phosphorylated cDNA expression libraries. Several potential Src substrates were identified including Fish, which has five SH3 domains and a recently discovered phox homology (PX) domain. Fish is tyrosine‐phosphorylated in Src‐transformed fibroblasts (suggesting that it is a target of Src in vivo) and in normal cells following treatment with several growth factors. Treatment of cells with cytochalasin D also resulted in rapid tyrosine phosphorylation of Fish, concomitant with activation of Src. These data suggest that Fish is involved in signalling by tyrosine kinases, and imply a specialized role in the actin cytoskeleton.
The Norwegian naturalistic treatment study of depression in general practice (NORDEP)—I: randomised double blind study

Abstract Objective: To evaluate the efficacy of emotional support and counselling combined with placebo or antidepressants with single or dual mechanism of action in the treatment of depression in primary care. Design: Randomised double blind study. Setting: Several locations in Norway. Subjects: 372 patients with depression. Main outcome measures: Improvement (clinical remission) reported both by the patient (Montgomery Åsberg depression rating scale) and the physician (clinical global improvement and impression scales). Results: Intention to treat analyses showed 47% remission in patients randomised to placebo compared with 61% remission in patients randomised to sertraline (odds ratio 0.56, 95% confidence interval 0.33 to 0.96) and 54% in patients randomised to mianserin (0.75, 0.44 to 1.27). Women responded better than men (1.86, 1.17 to 2.96). Subgroup analyses showed that subjects with recurrent depression (n=273) responded more frequently to sertraline than to placebo (0.43, 0.23 to 0.82) than those having their first episode of depression (1.18, 0.39 to 3.61). Statistically significant interactions between type of drug treatment and history of depression were not shown by logistic regression. Conclusion: The combination of active drug and simple psychological treatment (counselling, emotional support, and close follow up over a 24 week period) was more effective than simple psychological treatment alone, in particular for those with recurrent depression. Overall, women may benefit more than men. If confirmed in future studies, the findings should lead to more differentiated treatment guidelines for depression in primary care.
Wideband Tympanometry Normative Data for Different Age Groups in Turkish Population.

OBJECTIVE Studies on the use of wideband tympanometry (WBT) for the evaluation of middle ear pathologies have been increasing gradually in recent years. However, studies regarding normative data of WBT are not sufficient. The aim of this study was to determine normative values of WBT for different age groups in Turkish population. MATERIALS AND METHODS One hundred fifty volunteers from five age-related groups were included in this study. Values of resonance frequency (RF), absorbance percentage according to frequency, maximum absorbance ratio, and maximum absorbance frequency were obtained using WBT. Measurements were recorded at a pressure of 0 decapascal (daPa) using a sound stimulus given at 90±3 decibel sound pressure level (dB SPL). RESULTS The RF was detected to be significantly lower only in the group of subjects in the age range of 0-1 month. The absorbance value at 250 Hz was detected to be significantly higher in the age groups of 0-1 month and 1 month-2 years than in the other groups. CONCLUSION We believe that the findings obtained in this study would be helpful in determining normative data regarding WBT; by the determination of this normative data, the clinical use of WBT would become widespread.
Understanding the relationship between lung function and cardiovascular phenotypes in the young: opportunity for a better cardiovascular risk prevention in adulthood?

R espiratory and cardiovascular diseases (CVD) are major public health problems worldwide. They contribute substantially to the global morbidity and mortality burden and are often associated with a substantial reduction of the quality of life [1,2]. Several studies have documented associations between multiple measures of lung function, and cardiovascular risk factors, subclinical measures of CVD or risk of CVD mortality [3–9]. Among these, the most reported associations are between forced expiratory volume 1 (FEV1) or forced vital capacity (FVC) and current or future risk of high blood pressure (BP)/hypertension. In this issue of the Journal of Hypertension, Lu et al. reported results from the multiethnic young population of the Determinants of young Adult Social well-being and Health (DASH) study [10], confirming a strong relationship between lung function and SBP. The authors described a positive association between change in FEV1 and raise in SBP over 10 years. Importantly, this association remained highly significant after adjustment for several covariates, including age, sex, employment, ethnicity, racism, weightto-height ratio, and smoking use. In addition, the availability of central (aortic) haemodynamic parameters [including pulse wave velocity (PWV) and augmentation index] at the end of the follow-up provided the authors with the opportunity to test the association between these variables and cross-sectional measurements or longitudinal changes of FEV1, which resulted nonsignificant. Based on these findings, Lu et al. conclude that earlier lung function plays important roles in SBP development [10].
Integrin-associated protein and thrombospondin-1 as endothelial mechanosensitive death mediators.

Recently, it was reported that the offset of hemodynamic forces induces an unusual pattern of apoptosis in vascular endothelium (1). Although the apoptotic trigger covers all cells and is maintained for a longer time period, only few cells become apoptotic. So, in contrast to common apoptosis inducers, the lack of hemodynamic forces initiates only a low basal level of apoptosis, however steadily increases with time, this way preventing the complete vessel destruction upon an only transient offset of blood flow. The molecular means by which the mechanical stimulus and apoptosis are smoothly coupled have now been identified as an autocrine loop of thrombospondin-1 (TSP-1) and the alpha(v)beta(3) integrin/integrin-associated protein (IAP) complex as its receptor. Vascular EC (EC) secrete TSP-1 only in postconfluent static monolayers and not under flow. This also holds true for the IAP whereas the alpha(v)beta(3) integrin is present under static conditions, as well as under flow, assigning the IAP an essential and new switch function in the receptor complex.
Two Is Not Enough: Privacy Assessment of Aggregation Schemes in Smart Metering

Abstract The widespread deployment of smart meters that frequently report energy consumption information, is a known threat to consumers’ privacy. Many promising privacy protection mechanisms based on secure aggregation schemes have been proposed. Even though these schemes are cryptographically secure, the energy provider has access to the plaintext aggregated power consumption. A privacy trade-off exists between the size of the aggregation scheme and the personal data that might be leaked, where smaller aggregation sizes leak more personal data. Recently, a UK industrial body has studied this privacy trade-off and identified that two smart meters forming an aggregate, are sufficient to achieve privacy. In this work, we challenge this study and investigate which aggregation sizes are sufficient to achieve privacy in the smart grid. Therefore, we propose a flexible, yet formal privacy metric using a cryptographic game based definition. Studying publicly-available, real world energy consumption datasets with various temporal resolutions, ranging from minutes to hourly intervals, we show that a typical household can be identified with very high probability. For example, we observe a 50% advantage over random guessing in identifying households for an aggregation size of 20 households with a 15-minutes reporting interval. Furthermore, our results indicate that single appliances can be identified with significant probability in aggregation sizes up to 10 households.
Reliability and Validity of the VmaxST Portable Metabolic Analyzer

Background: The reliability and validity of the SensorMedics VmaxST was tested. Methods: Thirty subjects (age = 24.5 ± 4.0 years, height = 174.8 ± 9.8 cm, weight = 70.3 ± 12.6 kg) performed treadmill exercise on three occasions, twice using the VmaxST and once using the SensorMedics 2900 system. Oxygen consumption (VO2; L/min) and heart rate (HR; beats/min) were measured continuously during three, 6- minute stages: 80 m/min, 0% grade; 94 m/min, 5% grade; and 160 m/min, 0% grade, and VO2max. Results: Reliability was high, and measurement error was low for VO2 (Rxx range = 0.97 - 0.99, CI = 0.94 - 1.00, SEM = 0.03 - 0.08 L/min) and HR (Rxx = 0.94 - 0.99, CI = 0.88 - 1.00, SEM = 1.8 - 3.2 beats/min). Validity was high for VO2 (Rxy range = 0.92 - 0.98, CI = 0.84 - 0.99, SEE = 0.08 - 0.21 L/min) and HR (Rxy = 0.97 - 0.99, CI = 0.94 - 1.00, SEE = 0.9 - 1.8 beats/min). Mean differences in VO2 between VmaxST and 2900 were small yet significant (P < 0.001). Conclusions: The VmaxST demonstrated excellent reliabilit.
Argyrophilic nucleolar organizer region counts predict survival in thymoma

Background. The prognosis of thymoma is related mainly to the tumor stage. The prognostic value of argyrophilic nucleolar organizer regions (AgNORs) has been demonstrated in several human neoplasias. Ninety primary thymomas were investigated retrospectively to assess whether AgNOR analysis could offer additional prognostic information.
Protein Kinase C μ Is Negatively Regulated by 14-3-3 Signal Transduction Proteins*

Recent studies have documented direct interaction between 14-3-3 proteins and key molecules in signal transduction pathways like Ras, Cbl, and protein kinases. In T cells, the 14-3-3τ isoform has been shown to associate with protein kinase C θ and to negatively regulate interleukin-2 secretion. Here we present data that 14-3-3τ interacts with protein kinase C μ (PKCμ), a subtype that differs from other PKC members in structure and activation mechanisms. Specific interaction of PKCμ and 14-3-3τ can be shown in the T cell line Jurkat by immunocoprecipitiation and by pulldown assays of either endogenous or overexpressed proteins using PKCμ-specific antibodies and GST-14-3-3 fusion proteins, respectively. Using PKCμ deletion mutants, the 14-3-3τ binding region is mapped within the regulatory C1 domain. Binding of 14-3-3τ to PKCμ is significantly enhanced upon phorbol ester stimulation of PKCμ kinase activity in Jurkat cells and occurs via a Cbl-like serine containing consensus motif. However, 14-3-3τ is not a substrate of PKCμ. In contrast 14-3-3τ strongly down-regulates PKCμ kinase activity in vitro. Moreover, overexpression of 14-3-3τ significantly reduced phorbol ester induced activation of PKCμ kinase activity in intact cells. We therefore conclude that 14-3-3τ is a negative regulator of PKCμ in T cells.