Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Cloning of Mouse Ganglioside Sialidase and Its Increased Expression in Neuro2a Cell Differentiation*

Ganglioside sialidases have been implicated in neuronal differentiation processes, including neurite outgrowth. To understand further the roles and regulation mechanisms of the sialidase in neuronal systems, we have cloned mouse ganglioside sialidase cDNA and observed its expression in Neuro2a cell differentiation. A 3339-base pair cDNA, cloned based on the sequence information of previously cloned enzymes, encodes 418 amino acids containing three Asp boxes characteristic of sialidases. Northern blot analysis revealed a 3.4-kilobase transcript expressed highly in heart but also in several other tissues including brain. In situ hybridization of mouse brain demonstrated the mRNA to be present in the cerebral cortex, as well as in the granule cell layer, Purkinje cells, and deep cerebellar nucleus of the cerebellum. Transient expression of the cDNA in COS-1 cells resulted in over 300-fold increase in sialidase activity toward gangliosides compared with the control level, with a preference for ganglioside substrate. During 5-bromodeoxyuridine-induced Neuro2a cell differentiation, the expression of the sialidase was increased as assessed by activity assays and quantitative reverse transcription-polymerase chain reaction analyses. Stable transfection of the sialidase in Neuro2a cells resulted in accelerated neurite arborization following 5-bromodeoxyuridine treatment, indicating the direct participation of this ganglioside sialidase in neuronal cell differentiation.
Counterintuitive Investment Opportunities in the WSE. Evidence from the Field of Asset Pricing

How mispriced is the equity in emerging economies? We join this academic discussion by studying stock returns in the contemporary stock market of Poland. We test for abnormal excess returns yield using classic and modern asset pricing models. We report the evidence of certain time-varying return patterns that show investment potential. While size, investment, and momentum effects are not unequivocal enough to advertise them as trading opportunities, strategies based on profitability and value anomaly are evident and persistent throughout different investment climates. Counterintuitively, at an aggregated level we report higher level of mispricing, and thus higher abnormal investment opportunities, in the period of bear market and stable macro-conditions (2000-2006) than during and after the recent global financial crisis (2007-2013). We advocate that in emerging stock markets, like the Warsaw Stock Exchange, investors’ asset pricing skills outweigh the effect of international portfolio rebalancing in the process of asset pricing.
The value of financial advice: An analysis of the investment performance of advised and non-advised individual investors

ABSTRACT This study investigates the value added by financial advisors on the investment performance of advised versus non-advised individuals. A sample of 4 142 individual investors from a large South African investment house were analysed over a period of 10 years from 1 January 2005 to 31 December 2014. The data was analysed to draw conclusions on the return and trading behaviour of investors. The results indicate no statistical difference between the returns generated between advised and non-advised investors. However, advised investors make statistically significantly more trades than non-advised investors. The results indicate that there is no significant additional benefit of utilising a financial advisor, after the initial fund selection decision has been made.
Determination of Optimal Loading During the Power Clean, in Collegiate Athletes

Abstract Comfort, P, Fletcher, C, and McMahon, JJ. Determination of optimal loading during the power clean, in collegiate athletes. J Strength Cond Res 26(11): 2970–2974, 2012—Although previous research has been performed in similar areas of study, the optimal load for the development of peak power during training remains controversial, and this has yet to be established in collegiate level athletes. The purpose of this study was to determine the optimal load to achieve peak power output during the power clean in collegiate athletes. Nineteen male collegiate athletes (age 21.5 ± 1.4 years; height 173.86 ± 7.98 cm; body mass 78.85 ± 8.67 kg) performed 3 repetitions of power cleans, while standing on a force platform, using loads of 30, 40, 50, 60, 70, and 80% of their predetermined 1-repetition maximum (1RM) power clean, in a randomized, counterbalanced order. Peak power output occurred at 70% 1RM (2,951.7 ± 931.71 W), which was significantly greater than the 30% (2,149.5 ± 406.98 W, p = 0.007), 40% (2,201.0 ± 438.82 W, p = 0.04), and 50% (2,231.1 ± 501.09 W, p = 0.05) conditions, although not significantly different when compared with the 60 and 80% 1RM loads. In addition, force increased with an increase in load, with peak force occurring at 80% 1RM (1,939.1 ± 320.97 N), which was significantly greater (p < 0.001) than the 30, 40, 50, and 60% 1RM loads but not significantly greater (p > 0.05) than the 70% 1RM load (1,921.2 ± 345.16 N). In contrast, there was no significant difference (p > 0.05) in rate of force development across loads. When training to maximize force and power, it may be advantageous to use loads equivalent to 60–80% of the 1RM, in collegiate level athletes.
MGNEUROPATHY DIABETES HEART PROTECTION OVERACTIVE BLADDER PROSTATE BONES BONES BLOOD PRESSURE BLOOD PRESSURE BLOOD PRESSURE KIDNEY PROTECTION BLOOD PRESSURE KIDNEY PROTECTION BLOOD PRESSURE DIURETIC JOINT PAIN CHOLESTEROL LOTREL LOPRESSOR ORETIC ZOCOR TYLENOL PLENDIL ZESTRIL FOSAMAX CALTRATE FLOMAX 

Correspondence: Jeannie Kim Lee Clinical Assistant Professor, Department of Pharmacy Practice and Science, University of Arizona, College of Pharmacy, 1295 N. Martin Ave. P.O. Box 210202, Tucson, AZ 85721-0202, USA Tel +1 520 626 9419 Fax +1 520 626 7355 Email jlee@pharmacy.arizona. edu Abstract: Clinical practice research provides a unique opportunity to care for a diverse patient population in various health care system settings. Federal study of Adherence to Medications in the Elderly (FAME) was the fi rst prospective observational and randomized controlled trial to implement effective strategies to enhance medication adherence and health outcomes in older patients using polypharmacy. Ten lessons learned from conducting this adherence intervention trial are described: (1) Link the trial to existing clinical work, (2) Begin with a thorough understanding of medication adherence, (3) Ensure that trial highlights individualized intervention, (4) Tailor inclusion criteria and study duration to target population, (5) Employ a range of outcomes linked to meaningful clinical effects, (6) Win the support of the multidisciplinary team and the administration, (7) Promote team work, (8) Consider the potential limitations, (9) Seize the grant opportunities, and (10) Share the fi ndings.
Online corporate social responsibility (CSR) disclosure in the banking industry

Purpose – The purpose of this paper is twofold: first, this study analyzes the extent to which banks report online their corporate social responsibility (CSR) practices; second, it determines the impact of size, ownership structure, multiple exchange listing, and the internationalization of banks on the level of their online CSR reporting. Design/methodology/approach – This study examines the Turkish banking industry’s online CSR communications by performing a content analysis of banks’ online reporting of their CSR practices in four sub-dimensions, namely, environment and energy, human resources, products and customers, and community involvement. A sample of 25 banks in Turkey was grouped according to the criteria of size, ownership structure (listed or unlisted on stock exchanges), multiple exchange listing (listing on home and foreign exchanges), and internationality (local or foreign). This study employs a nonparametric Kruskal-Wallis test to determine the significance of the differences among these g.
Microsatellite instability in esophageal squamous cell carcinoma is not associated with hMLH1 promoter hypermethylation

To test whether a subset of esophageal squamous cell carcinomas (SCC) develop through a deficiency in DNA mismatch repair, we examined microsatellite instability (MSI) using 11 microsatellite markers including BAT‐26, hMLH1 protein expression by immunohistochemistry, and methylation status of the hMLH1 promoter by methylation‐specific polymerase chain reaction (MSP). p53 mutations were also investigated. Microsatellite instability at one or more loci was observed in 40% (12/30) of esophageal SCC tumor samples, although only one of these tumors was categorized as high‐frequency MSI (MSI‐H) and none showed BAT‐26 instability. While immunohistochemistry revealed decreased hMLH1 protein expression in 27% (8/30) of the tumors, hMLH1 promoter hypermethylation was not observed. Absence of hMLH1 protein expression was relatively common in well‐differentiated (keratinizing‐type) esophageal SCC, but was not associated with hMLH1 promoter hypermethylation. p53 mutation was detected in 37% (11/30) and loss of heterozygosity (LOH) in 90% (27/30) of esophageal SCC samples. Our results suggested that most esophageal SCC develop through defects in tumor suppressor genes (i.e. the suppressor pathway), and that MSI in esophageal SCC probably represent random replication errors rather than being associated with DNA mismatch repair deficiency.
A conceptual model for e-commerce adoption in developing countries: a task-technology fit perspective

The adoption of B2B e-commerce in developed economies has, overall, been successful. This success, however, has not been reflected in developing countries, indicating that models for IT adoption in developed economies may not be appropriate. In response to this we develop a strategic fit perspective to investigate the issue of successful adoption of interorganisational information technologies in developing countries. This perspective is operationalised through the Task-Technology Fit (TTF) model by integrating interorganisational theories and theories of national culture. The model demonstrates that in an interorganisational context the fit of technologies to support tasks may not have the desired impact on performance in developing economies without considering the precursors of utilisation, national culture, the nature of business relationships, and the readiness of the technological infrastructure in the implementation environment. The model may be useful for better understanding how organisations in developing countries may adopt e-commerce technologies enabling online business processes in B2B settings.
Should the 'adenosine-challenge test' be part of the routine work-up for syncope?

The adenosine compounds [adenosine and adenosine triphosphate (ATP)] exert negative chronotropic and dromotropic effects at the level of the sinus node and atrio-ventricular (AV) node.1 These effects are both potent and short lasting. Therefore, the adenosine compounds replaced verapamil as the first-line drug for terminating re-entrant supraventricular tachycardias involving the AV node (AV node re-entry tachycardia or AV reciprocating tachycardia). 1 Cardiologists also take advantage of these effects for diagnostic purposes.2 For example, the transient AV block caused by iv injection of adenosine during sinus rhythm allows the identification of antegrade accessory pathways in patients with Wolff–Parkinson– White syndrome when only minor pre-excitation is present.3 Similarly, we have used the ‘adenosine challenge test’ for the identification of the presence of dual AV-node physiology and concealed (retrograde) accessory pathways in patients palpitations of unclear aetiology.4 Finally, since sudden bradycardia has strong effects on ventricular repolarization, we have proposed the ‘adenosine challenge test’ for diagnosing congenitally long QT syndrome.5 In this issue of Europace , Fragakis et al. 's data suggest that the ‘adenosine challenge test’ may be as effective as …
A Study of the Relationship between Customer Satisfaction and Customer Loyalty toward an Economy Hotel Chain in Guangzhou, China

This research aims to examine the main factors affecting customer loyalty and investigate the relationships between customer satisfaction on service quality and price and customer loyalty toward an economy hotel chain in city of Guangzhou, in the Guangdong province, China. Self-administered questionnaires were collected from 402 customers who have stayed in 7 Days hotels and the Pearson correlation employed for data analysis. The results of this study confirmed that service quality dimensions and perceived price are the main drivers of customer satisfaction in terms of affecting customer loyalty. Surprisingly, the findings also show that perceived price has a stronger impact on customer loyalty than any other service quality dimensions.
Describing function analysis of the electric nonlinear model of a SRM autonomous AC generator

This paper focuses on the Switched Reluctance Motor (SRM) used as self-excited generator. The phase inductance resonates autonomously with an external capacitor parallel connected producing an AC voltage almost sinusoidal. Although the voltage quality is not good enough to be directly connected the network utility it is able to be used as a battery charger in isolated locations. As the machine shows a nonlinear relationship among current, flux and angular position, the system equations are nonlinear therefore, analytical solutions describing its behaviour can not be found. However, it is shown that the system follows a known nonlinear second order equation describing mechanical systems. This experience is transferred to gain insight in this application. It is shown that the steady state can be identified as a limit cycle whose main variables are derived. The analysis procedure followed is known as the describing function method. It is an extended version of the frequency response method, and can be used to approximately analyze and predict nonlinear behaviour. The main use of describing function method is for the prediction of limit cycles in nonlinear systems. A simulated example is developed to illustrate the method and to derive the relationship among the electrical variables, useful for design purposes.
Discretionary Measurement of Level 3 Fair Values During the 2008 Financial Crisis

In the absence of quoted prices in active markets, the measurement of fair values is complex and difficult to verify. Prior literature finds that investors discount fair value estimates based on unobservable inputs (i.e., Level 3). However, these value relevance tests cannot discern whether the discount is attributable to managerial opportunism or illiquidity concerns. This paper examines whether banks use Level 3 fair value estimates to manage earnings during the 2008 Financial Crisis. Based on a sample of 329 U.S. banks, we find that banks with earnings management incentives (i.e., low earnings, negative change in earnings, small negative earnings, and low Tier 1 capital) recognize lower-than-necessary losses on Level 3 positions. Our inferences are robust to alternative specifications including the use of bank fixed effects, placebo tests with Level 3 gains or losses recognized in other comprehensive income (OCI), and benchmarking against discretionary loan loss provisions (LLP).
Experimental Pain Responses Support Peripheral and Central Sensitization in Patients With Unilateral Shoulder Pain

Objective:The aims of this study were to (1) examine the pattern of experimental pain responses in the affected and nonaffected extremities in patients with shoulder pain and (2) explore the intraindividual association between sensitization states derived from experimental pain testing. Methods:Experimental pain responses from 58 patients with shoulder pain (17 women, aged 18 to 52 y) were compared with those from 56 age-matched and sex-matched pain-free volunteers (16 women, aged 21 to 58 y). Experimental pain responses included pressure pain threshold (PPT), thermal pain threshold and tolerance, and suprathreshold heat pain response. Comparisons were made between the affected and nonaffected extremities of clinical participants and the average response of extremities in control participants. Peripheral and central sensitization indexes were computed for clinical participants using standardized scores and percentile cutoffs on the basis of the data from the control sample. Experimental pain responses in clinical participants observed beyond the 25th and 75th percentile of control sample responses were used for investigation of intraindividual association of sensitization states. Results:PPT at the acromion and masseter on the affected side of clinical participants were diminished compared with that on their nonaffected side (P<0.015). Bilateral sensitivity in clinical participants was noted for PPT at the acromion and suprathreshold heat pain response (P<0.015). Peripheral and central sensitization indexes demonstrated that individuals with shoulder pain present with variable patterns of peripheral and central sensitization. Conclusions:Collectively, experimental pain responses supported peripheral and central sensitization in response to pressure and thermal stimuli. No clear association was made between individuals exhibiting peripheral or central sensitization, thus suggesting heterogeneity in pain processing in this clinical population.
Health Related Quality of life after Corrective Surgery for Congenital Heart Disease

Abstract After corrective surgery for congenital heart defects (CHD) many patients suffer from residual defects, some with reduced cardiorespiratory capacity and possible impairment of their health related quality of life (HRQoL). The aim of our study is to evaluate, how children after surgery for CHD rate their HRQoL. Method: A standardised questionnaire developed for self-rating in children between 8 and 18 years and dealing with 7 different domains concerning the HRQoL (friends, family, physical functioning, cognition, body image, emotional function and autonomy) was independently answered from patients and their parents during an outpatient visit at their pediatric cardiologist throughout Germany. Results: 173 patients (40% female, 60% male, mean age 11.6 years) were interviewed, 167 questionnaires could be evaluated. The mean time interval after surgery was 9.8±3.4 years. Patient had had surgery for complete different types of CHD (ventricular septal defects n=50, Tetralogy of Fallot n=51, univentricular heart n=26, transposition of great arteries n=40). The results were compared with those of an age-matched control group (n=169). Patients with CHD reported a better HRQoL than the controls for all items (p<0.01). There was no significant gender specific difference. After puberty, the rating for most items, except of “body image“, had become very similar compared to controls. Parents assessed their children significantly worse in 3 domains (friends, body image and emotion; p<0.01). Conclusion: Children with congenital heart defects are able to develop coping structures, that enable them to live a normal life from their individual point of view. Integration in psychosocial structures seems to be rather normal when compared to healthy controls. Many patients considered their HRQoL as even better.
Implantation Metastasis after Percutaneous Transthoracic Needle Aspiration Biopsy

The risk of tumour spread at aspiration biopsy of pulmonary tumours through the needle track has been analyzed by reviewing the case histories of 1 264 patients with a malignant tumour demonstrated by needle biopsy. Only in one case did metastatic tumour growth develop at the site of the biopsy. The history of this case is presented and the available literature on the subject discussed.
Intersection and Union Types for X

This paper presents a notion of intersection and union type assignment for the calculus X , a substitution free language that can be used to describe the behaviour of functional programming languages at a very low level of granularity, and has first been defined in [14, 5]. X has been designed to give a Curry-Howard-de Bruijn correspondence to the sequent calculus for classical logic. In this paper we will define a notion of sequent-style intersection type assignment on X that needs union types, and show that this notion is closed for both subject-reduction and subject-expansion. We will also show that it is an extension of the Strict system for lc.
Knowledge of Management Tools and Systems in SMEs: Knowledge Transfer in Management

The chapter deals with knowledge management principles and their implication to knowledge in management represented by contemporary sophisticated management tools and systems. The most important management branches and methods, tools and systems, generally considered as very helpful for professional business operating, are presented. Further research results of management tools knowledge in contemporary enterprises are presented impacting the need of education and knowledge transfer in management responsible positions. The need of management knowledge for the competitiveness of enterprises is accented. Business and competitive intelligence as media for competitiveness are introduced. In the last part of the chapter, a model of the knowledge management system applicable in SMEs is suggested. The purpose of the chapter is to make the reader familiar with some of the most important management tools, methods and systems and suggest principles for an easy and effective knowledge management system in the enterprise.
Enjoy your heart-beets. The role of dietary inorganic nitrate in cardiovascular health.

Kardiologia Polska Copyright © Polskie Towarzystwo Kardiologiczne 2016 Andrzej Beręsewicz, MD, PhD, professor emeritus in the Department of Clinical Physiology, Postgraduate Medical School, Warsaw, Poland, former head of the Department (1999–2014). He graduated from the Medical Faculty, Warsaw Medical School (1968) and started his research career in the Department of Clinical Physiology in 1971. His main research interests include: myocardial ischaemia/reperfusion injury, endogenous cardioprotective mechanisms, post-ischaemic coronary endothelial dysfunction, and no-reflow phenomenon, mechanisms of vascular oxidative stress. Memberships: Polish Physiological Society; Polish Cardiac Society; International Society for Heart Research; The Physiological Society.
Elliptic solutions in the Neumann–Rosochatius system with mixed flux

Closed strings spinning in AdS_3 x S^3 x T^4 with mixed Ramond-Ramond and Neveu-Schwarz-NeveuSchwarz three-form fluxes are described by a deformation of the one-dimensional Neumann-Rosochatius integrable system. In this articlewe find general solutions to this systemthat can be expressed in terms of elliptic functions. We consider closed strings rotating either in S^3 with two different angularmomenta or in AdS_3 with one spin. To find the solutions, we will need to extend the Uhlenbeck integrals of motion of the Neumann-Rosochatius system to include the contribution from the flux. In the limit of pure Neveu-Schwarz-NeveuSchwarz flux, where the problem can be described by a supersymmetricWess-Zumino-Witten model, we find exact expressions for the classical energy in terms of the spin and the angular momenta of the spinning string.