Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacokinetics of cefaronide, ceftriaxone and cefoperazone in sheep.

The pharmacokinetics of cefaronide (16 gm/kg dose), ceftriaxone and cefoperazone (47 gm/kg dose), after intravenous (i.v.) administration were determined in six Merino ewes. The mean values for terminal half life, steady state volume of distribution Vd(ss), renal clearance (ClR) and total body clearance (ClB) for cefaronide were 1.5 h, 0.39 l/kg, 0.06 l/h/kg and 0.16 l/h/kg, for ceftriaxone; 1.7 h, 0.30 l/kg, 0.08 l/h/kg, and 0.22 l/h/kg, and 0.7 h, 0.16 l/kg, 0.02 l/h/kg and 0.16 l/h/kg for cefoperazone, respectively. After 5.5 h, approximately 42% cefaronide, and after 8 h, approximately 37% ceftriaxone and 13% cefoperazone, was excreted in urine. The non-renal elimination of ceftriaxone and cefoperazone appeared to be more rapid in sheep than is reported in man. Cefaronide was excreted largely unchanged in the urine of sheep. Therefore, the elimination of cefaronide in sheep was similar to that found in man. Cefaronide was well distributed in sheep, whereas ceftriaxone and cefoperazone appeared to be distributed to a lesser degree. These findings underline the different disposition of drugs in different species.
The Role of Ego Network Structure in Facilitating Ego Network Innovations

type="main" xml:id="jscm12075-abs-0001"> A great deal of research on innovation implicitly relies upon the network in which a firm is embedded to explain its innovative capabilities. Interestingly, however, most research examines innovation at the firm level, rather than at the network level. Thus, there is a significant gap in the literature regarding the effects of network structure on innovation within a firm's network. In this research, we contribute to the literature of supply chain innovations by developing and testing theoretically derived hypotheses regarding the effect of network structure on innovation output and distribution, as measured by the aggregate count and variance in the distribution of patents of the ego network in which a firm exists. Utilizing a manufacturing joint venture network dataset, we identify effects of various ego network constructs such as betweenness, density, brokerage, and weakness on ego network innovation. We find support for the idea that innovation in a supply chain is highly dependent upon the network structure of the interfirm relationships. Thus, it is not just what you know or how well you individually innovate, but also how well the firm can leverage its supply network connections that engender superior innovation outcomes.
TRAUMA-SHOCK-INDUCED GUT INJURY AND THE PRODUCTION OF BIOLOGICALLY ACTIVE INTESTINAL LYMPH IS ABROGATED BY CASTRATION IN A LARGE ANIMAL PORCINE MODEL

Although small animal rodent studies indicate that there is a sexual dimorphism in the resistance to organ injury after trauma-hemorrhagic shock (T/HS), confirmatory studies are largely lacking in more clinically relevant large animal species. Thus, we tested the hypothesis that castration would reduce the susceptibility of adult minipigs to gut injury and abrogate the production of biologically active intestinal (mesenteric) lymph after T/HS. The hemodynamic response to T/HS was similar between castrated and noncastrated minipigs. Mesenteric lymph collected during the preshock period and in the trauma-sham shock (T/SS) animals did not have increased biological activity. However, T/HS-lymph from the noncastrated males increased the respiratory burst of normal neutrophils, increased endothelial cell monolayer permeability, and was cytotoxic for endothelial cells. Castration abrogated the T/HS-induced neutrophil-activating and endothelial-injurious activities of mesenteric lymph, and the biological activity of the T/HS-lymph from the castrated minipigs was not different from the T/SS animals. As compared with the T/SS minipigs, T/HS increased ileal mucosal injury and intestinal permeability. This increase in gut permeability after T/HS was manifest by in vivo bacterial translocation and by the increased passage of bacteria as well as permeability probes across intestinal segments when tested in the Ussing chamber system. In contrast, neither mucosal injury nor increased intestinal permeability was observed in the castrated minipigs subjected to T/HS. In summary, this large animal porcine study validates the notion that castration limits gut injury and the production of biologically active intestinal lymph after T/HS.
The Effects of State Innovation Programs on Entrepreneurial Firms: Three Essays.

My dissertation provides new evidence on the effects of state innovation programs on entrepreneurial science and technology companies in the Great Lakes region. The first essay examines the extent to which, if at all, competitive R&D awards from Michigan innovation programs enhance the performance of participating ventures relative to startups that seek but fail to receive an award. I then expand scope to other states in the Great Lakes region and investigate the broader implications of large-scale programs on entrepreneurial activity, including patterns of entry and survival (Essay 2) and the retention of innovation-oriented startups within a state (Essay 3). Category: Entrepreneurship; Strategy; Public Policy
Identification and computationally‐based structural interpretation of naturally occurring variants of human protein C

Protein C (PC) is a key regulator of blood clotting and inflammation. Its inherited deficiency is associated with venous thromboembolism, and recombinant activated PC is currently used to increase survival in severe sepsis. The molecular basis of inherited PC deficiency is heterogeneous. Due to its multiple physiologic interactions and functions, and its modular structure, natural variants aid in the understanding of the relationship between critical residues and discrete functions. This knowledge has important therapeutic implications in the planning of a recombinant activated PC with a specific therapeutic target and devoid of major collateral effects. A way of predicting important functional consequences of residue variation is the use of molecular modeling and structural interpretation of amino acidic substitutions. A study of 21 out of 32 identified PC gene (PROC) variants is presented. For three of them, localized in the active site, electrostatic potential variation was calculated. For more than half of the studied variants, an explanation for the functional impairment could be derived from computational analysis, allowing a focused choice of which variants it is worthwhile pursuing. Hum Mutat 28(4), 345–355, 2007. © 2006 Wiley‐Liss, Inc.
The antecedents of service quality and product quality and their influences on bank reputation: evidence from the banking industry in China

Although an increasing number of studies is being performed in the field of service management, less work is being done on an integrated framework of service quality and product quality, especially that supported with evidence from developing countries. As a result, little is known about the distinction between service quality and product quality, their respective antecedents, and their distinctive contributions to performance in service industries in the developing world. Generalization of related findings from developed countries is not necessarily appropriate. Unlike most related studies that are based on evidence from developed countries, focuses attention on the distinction between, and respective antecedents of, service quality and product quality in the Chinese context. Gives much emphasis to the importance of a positive bank reputation. The findings are based on structural equation models developed by AMOS.
Supplier perceptions of knowledge sharing in buyer-supplier relationships: a service example

The increasing need for supply chain visibility and strategic partnership depends on buyer-supplier relationship and business to business (B2B) sharing of explicit and tacit knowledge. This study examines how the behavioural and psychological determinants contribute to the sharing of explicit and tacit knowledge between buyer and supplier. Surveys collected from 100 US service supplier organisations show that collective responsibility for risks and benefits, discussing long term planning; making decisions beneficial to each other and mutual dependency are instrumental in successful buyer-supplier knowledge sharing. While both explicit and tacit knowledge are perceived significant, explicit knowledge contributes to the sharing of core business processes while tacit knowledge is associated with the sharing of environmental and business planning information. Furthermore, as-needed specialty and preferred vendor contracts facilitate the association of psychological determinants and buyer-supplier knowledge sh.
Channel Estimation via Orthogonal Matching Pursuit for Hybrid MIMO Systems in Millimeter Wave Communications

We propose an efficient open-loop channel estimator for a millimeter-wave (mm-wave) hybrid multiple-input multiple-output (MIMO) system consisting of radio-frequency (RF) beamformers with large antenna arrays followed by a baseband MIMO processor. A sparse signal recovery problem exploiting the sparse nature of mm-wave channels is formulated for channel estimation based on the parametric channel model with quantized angles of departures/arrivals (AoDs/AoAs), called the angle grids. The problem is solved by the orthogonal matching pursuit (OMP) algorithm employing a redundant dictionary consisting of array response vectors with finely quantized angle grids. We suggest the use of non-uniformly quantized angle grids and show that such grids reduce the coherence of the redundant dictionary. The lower and upper bounds of the sum-of-squared errors of the proposed OMP-based estimator are derived analytically: the lower bound is derived by considering the oracle estimator that assumes the knowledge of AoDs/AoAs, and the upper bound is derived based on the results of the OMP performance guarantees. The design of training vectors (or sensing matrix) is particularly important in hybrid MIMO systems, because the RF beamformer prevents the use of independent and identically distributed random training vectors, which are popular in compressed sensing. We design training vectors so that the total coherence of the equivalent sensing matrix is minimized for a given RF beamforming matrix, which is assumed to be unitary. It is observed that the estimation accuracy can be improved significantly by randomly permuting the columns of the RF beamforming matrix. The simulation results demonstrate the advantage of the proposed OMP with a redundant dictionary over the existing methods such as the least squares method and the OMP based on the virtual channel model.
Mycoplasma and cancer: in search of the link

Melissa B. Rogers * Biochemistry & Molecular Biology, UMDNJ - NJ Medical School, Newark, New Jersey Commentary on: Barykova, YA, DY Logunov, MM Shmarov, AZ Vinarov, DN Fiev, NA Vinarova, IV Rakovskaya, PS Baker, I Shyshynova, AJ Stephenson, EA Klein, BS Naroditsky, AL Gintsburg, and AV Gudkov, Association of Mycoplasma hominis infection with prostate cancer. Oncotarget, 2011; in press. Received: April 18, 2011; Accepted: April 19, 2011; Published: April 19, 2011; Correspondence: Melissa B. Rogers, e-mail: // //
Evaluation of ISO 4049: water sorption and water solubility of resin cements

The aim of this study was to evaluate the water sorption and solubility test design of ISO 4049 for resin cements. Sorption and solubility of six dual-curing resin cements [RelyX Unicem 2 Automix (RUN), Multilink Speed CEM (MLS), Panavia SA Plus (PSA), RelyX Ultimate (RUL), Multilink Automix (MLA), and Panavia V5 (PV5)] were analyzed by storage in distilled water after dual-curing. In addition, sorption and solubility during thermal cycling were assessed with self-cured and dual-cured specimens. After water storage, all cements revealed sorption in the range of 30 μg mm-3 except for PV5, for which sorption was markedly lower (mean ± SD = 20.8 ± 0.4 μg mm-3 ). Solubility values were negative for RUN and RUL (-2.1 ± 0.08 μg mm-3 and -1.9 ± 0.13 μg mm-3 , respectively). All other cements attained positive values in the range of 0.4-0.8 μg mm-3 . Thermal cycling effects were more pronounced. The assessment of water sorption according to ISO 4049 provides reliable results. Solubility results must be interpreted with care because absorbed water may distort the values.
Investor information and asset returns in production economies

In this thesis, I explore the implications of investor information for asset returns in general equilibrium economies with production. In the first chapter, I study what determines the relationship between information quality and long-run risk in a Cox-Ingersoll-Ross type model with recursive preferences. Building on the recent work by Ai (2010), I separate the risk premium into the short-run and long-run components to highlight aspects of preferences that are important for this relationship. It is shown that the attitude towards temporal resolution of uncertainty determines the direction in which changes in information quality alter the compensation for long-run risk, while the elasticity of intertemporal substitution is important for the amplitude of this effect. In the second chapter, I investigate how incomplete information affects asset returns in a real business cycle model with Epstein-Zin preferences. In the model economy, productivity is altered by both transitory and permanent shocks. The representative agent observes movements in productivity but cannot perfectly distinguish their sources. As a result he must solve a signal extraction problem. This incomplete information model is found to be quantitatively consistent with some common observations about asset prices and aggregate quantities, including, for example, the equity premium, the risk-free rate, the price-dividend ratio and the dynamics of consumption and output. Furthermore, the model generates a downward sloping term structure of equity risk as empirically observed − namely, assets with shortduration of cash flows have larger risk premium and return volatility than assets with long-duration of cash flows.
VARYING THE CONTENT OF JOB ADVERTISEMENTS: The Effects of Message Specificity

Organizations trying to attract job applicants face a trade-off in the design of their recruiting advertisements. The use of general ads that include limited job attribute specificity has the potential to appeal to a wide array of job applicants and to increase the size of the applicant pool. However, such advertisements may also increase the number of unqualified or inappropriate applicants pursuing employment, and may be unappealing to job candidates who are highly focused in their job search strategies. Using a three-factor experimental design, two studies examine the impact of providing specific/general information on three position facets (i.e., the company, the job itself, and the work context) on a series of dependent variables. Results suggest that all three facets of message specificity impact, to varying degrees, individuals' opinions about the ad, perceived appropriateness of the job, attitudes toward the ad and company, as well as intentions to complete the job application process.
Behavioral financial engineering in the fixed-income market: The influence of the coupon structure

In this paper we investigate the influence of coupon structure on the financial behavior of Individual Investors in the fixed-income market. Examining circa 26 million decisions on 204 standard putable bonds with different coupon offerings our major findings are: (i) Products with a flat coupon structure and a high duration attract fewer investors and are significantly more often exercised early, whereas financially equal products with a steeply rising coupon structure arouse more interest among investors and are less often redeemed early. (ii) The shape of the upcoming coupon structure is an important basis on which investors decide which putable bond in a portfolio to exercise early. (iii) Issuers who exploit empirical patterns related to a bond´s coupon structure through "behavioral financial engineering" can benefit from a lower liquidity demand and a diminishing empirical option value.
The Image and Perceived Quality of Universities as Important Dimensions for Building University Brand Equity -Case Study Involving Albanian Students

Research has shown that the probability of employment for individuals lacking proper qualification is four times smaller than that of those who possess proper qualification. Qualification helps people to occupy a decent job, that is to say a good paying job, with quality working conditions supplied by social and legal benefits and protection. A higher education degree is an investment in human capital however and in our country, the cost of this investment per individual is relatively high compared to the expected income. Since the investment to have a university degree is a rare purchase and for most students can be the first and last purchase, therefore the choice of university must be carefully evaluated which means that the image and the university's perceived quality can be the main selection criteria by students. Studies about brands, describe the impact of brand image through identification with the customer. This includes personal identification, where customers can identify themselves with some brands and therefore develop a level of fondness towards them. Therefore it can be suggested that people can enrich their image through the image of the brands they buy and use. Therefore, university students, as the most important group of interest are likely to identify their own self with the university they choose. Images of the university as a brand can be used by students to enrich their image, for example, students can begin to call themselves "boy / girl of X University". Andreassen and Lindestad (1998) have found that consumer retention is influenced by the image of corporate and consumer satisfaction. Within the context of a higher education, loyalty fostered by students can be furthered by the students' own perceived image of the university, as the observed quality of the university. This paper will attempt to treat the influence of perceived quality and image of the Albanian universities as the choice of study provided to Albanian students as well as the impact that these dimensions of brand equity impress upon Albanian universities.
IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes

Interleukin (IL)-2 is a type I four-α-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor α chain (IL-7Rα) mRNA and protein. The fact that IL-7Rα is a component of the receptors for both IL-7 and thymic stromal lymphopoietin (TSLP) suggests that IL-2 can negatively regulate signals by each of these cytokines. Previously it was known that the IL-2 and IL-7 receptors shared the common cytokine receptor γ chain, γc, which suggested a possible competition between these cytokines for a receptor component. Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that IL-2 signaling can diminish IL-7Rα expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism.
An estimate of the crosstalk matrix in four‐dye fluorescence‐based DNA sequencing

Color separation is an essential step of the data processing in the four‐dye fluorescence detection strategy used in automated DNA sequencing. In this paper, we propose a model to describe the crosstalk phenomenon, and show how the assumptions of the model are supported by experimental data. The crosstalk matrix is estimated via a reparameterization based on a mapping between the distribution of fluorescence intensities and that of dye concentrations. An iterative algorithm is designed to implement the estimation. To evaluate the color‐correction quality of a crosstalk matrix, we propose a quantitative measure based on the distribution of the color‐corrected data. We illustrate this method by applying it to a sequencing trace of slab gel electrophoresis obtained at the Human Genome Center at Lawrence Berkeley National Laboratory, and that of capillary electrophoresis provided by the Department of Chemistry at UC, Berkeley. The accuracy of this method is also assessed by the bootstrap method.
Ratifiable Collusion and Bidding Systems in Procurement

This study explores stability in ecient collusion in government procurement auctions. In first- and second-price auctions with independent private values, we look at the possibility of vetoing collusion mechanisms and the learning of the other bidders after vetoing. The collusions in first-price auctions in simple case and second-price auctions are stable against the competition after a potential veto to take part in bid-rigging.
Disparate immunoregulatory potentials for double-negative (CD4- CD8-) alpha beta and gamma delta T cells from human patients with cutaneous leishmaniasis.

Although most T lymphocytes express the alphabeta T-cell receptor and either CD4 or CD8 molecules, a small population of cells lacking these coreceptors, CD4- CD8- (double negative [DN]) T cells, has been identified in the peripheral immune system of mice and humans. To better understand the role that this population may have in the human immune response against Leishmania spp. , a detailed study defining the activation state, cytokine profile, and the heterogeneity of DN T cells bearing alphabeta or gammadelta T-cell receptors was performed with a group of well-defined cutaneous leishmaniasis patients. Strikingly, on average 75% of DN T cells from cutaneous leishmaniasis patients expressed the alphabeta T-cell receptor, with the remainder expressing the gammadelta receptor, while healthy donors displayed the opposite distribution with approximately 75% of the DN T cells expressing the gammadelta T-cell receptor. Additionally, alphabeta DN T cells from cutaneous leishmaniasis patients are compatible with previous antigen exposure and recent activation. Moreover, while alphabeta DN T cells from Leishmania-infected individuals present a proinflammatory cytokine profile, gammadelta DN T cells express a regulatory profile exemplified by interleukin-10 production. The balance between these subpopulations could allow for the formation of an effective cellular response while limiting its pathogenic potential.
Cost of Bereavement: How Does Parental Loss Affect Mutual Fund Managers?

This study examines whether bereavement, a common life experience, affect the performance and behaviors of mutual fund managers. We find that mutual fund return declines by around 3 percentage points around the parental deaths of fund managers. This underperformance persists for about one year, suggesting a longer-term negative impact of bereavement on fund managers’ cognitive ability. Additionally, the underperformance cannot be explained by alternative explanations such as physical distractions around parental death. Furthermore, bereaved managers’ investing behaviors also change around the parental deaths. Bereaved managers become 1) less likely to take risk, as they reduce tracking errors, shift holdings to larger stocks, and trade less actively; 2) more impatient, as they incur higher transaction costs and close their positions more quickly to realize gains; and 3) more sensitive to losses, as they are more likely to eliminate stocks following large negative returns. Our results identify bereavement as an underexplored life experience that can significantly influence investors’ performance and behaviors.