Miracle-dz/UniFAR-FTUs huggingface dataset:
Incorporation biologique de l'adversité sociale précoce : le rôle de la charge allostatique dans une perspective biographique

Introduction. La notion d'" embodiment " propose que chaque humain est a la fois un etre social ainsi que biologique, integrant le monde dans lequel il/elle vit. Nous faisons l'hypothese que la position socioeconomique pendant l'enfance peut etre biologiquement incorporee, conduisant a la production des inegalites sociales de sante entre les sous-groupes de population. La charge allostatique (CA) est un concept qui tente de capturer l'usure physiologique globale du corps liee a l'activation repetee des mecanismes physiologiques compensatoires en cas d'exposition a des stress chroniques. La CA pourrait permettre une meilleure comprehension des voies biologiques qui jouent un role potentiel dans la construction du gradient social de sante des adultes. Objectif. Pour explorer l'hypothese d'incorporation biologique, nous avons examine les voies de mediation entre les adversites psychosociales et la position socioeconomique precoces et la CA a 44 ans. Nous avons egalement confronte l'indice de CA a une mesure multidimensionnelle de sante latente a 50 ans. Methodes. Les donnees sont issues de la cohorte Britannique de naissance de 1958 (n=18 000). La CA a ete construite avec les donnees de l'enquete biomedicale conduite a 44 ans, comme une mesure physiologique synthetique, multi-systeme, a l'aide de 14 biomarqueurs representant les systemes neuroendocrinien, metabolique, immunitaire / inflammatoire et cardiorespiratoire. Resultats. L'ensemble de nos resultats suggerent que la CA pourrait etre un indice approprie pour capturer partiellement la dimension biologique des processus d'embodiment. Discussion. Comprendre comment l'environnement affecte notre sante en se " glissant sous la peau " et penetrant dans les cellules, les organes et les systemes physiologiques de notre corps est un principe cle dans la recherche en sante publique. Promouvoir le recueil de marqueurs biologiques dans des grandes etudes prospectives et representatives est crucial pour continuer la recherche sur ce sujet. Les etudes de replication pourraient faire partie des futures perspectives de recherche, pour comparer entre populations avec des contextes culturels differents pour observer si un index de CA peut etre considere comme "universel ".
Application of an Online-Coupled Regional Climate Model, WRF-CAM5, over East Asia for Examination of Ice Nucleation Schemes: Part I. Comprehensive Model Evaluation and Trend Analysis for 2006 and 2011

Online-coupled climate and chemistry models are necessary to realistically represent the interactions between climate variables and chemical species and accurately simulate aerosol direct and indirect effects on cloud, precipitation, and radiation. In this Part I of a two-part paper, simulations from the Weather Research and Forecasting model coupled with the physics package of Community Atmosphere Model (WRF-CAM5) are conducted with the default heterogeneous ice nucleation parameterization over East Asia for two full years: 2006 and 2011. A comprehensive model evaluation is performed using satellite and surface observations. The model shows an overall acceptable performance for major meteorological variables at the surface and in the boundary layer, as well as column variables (e.g., precipitation, cloud fraction, precipitating water vapor, downward longwave and shortwave radiation). Moderate to large biases exist for cloud condensation nuclei over oceanic areas, cloud variables (e.g., cloud droplet number concentration, cloud liquid and ice water paths, cloud optical depth, longwave and shortwave cloud forcing). These biases indicate a need to improve the model treatments for cloud processes, especially cloud droplets and ice nucleation, as well as to reduce uncertainty in the satellite retrievals. The model simulates well the column abundances of chemical species except for column SO2 but relatively poor for surface concentrations of several species such as CO, NO2, SO2, PM2.5, and PM10. Several reasons could contribute to the underestimation of major chemical species in East Asia including underestimations of anthropogenic emissions and natural dust emissions, uncertainties in the spatial and vertical distributions of the anthropogenic emissions, as well as biases in meteorological, radiative, and cloud predictions. Despite moderate to large biases in the chemical predictions, the model performance is generally consistent with or even better than that reported for East Asia with only a few exceptions. The model generally reproduces the observed seasonal variations and the difference between 2006 and 2011 for most variables or chemical species. Overall, these results demonstrate promising skills of WRF-CAM5 for long-term simulations at a regional scale and suggest several areas of potential improvements.
Effect of imidapril versus ramipril on urinary albumin excretion in hypertensive patients with type 2 diabetes and microalbuminuria

Objective: Aim of this study was to compare the antiproteinuric effect of imidapril (I) and ramipril (R) in diabetic hypertensive patients with microalbuminuria. Research design and methods: One hundred and seventy-six patients were randomised to I 10 – 20 mg once daily (od) (n = 88) or R 5 – 10 mg od (n = 88) for 24 weeks. Clinic, ambulatory, central blood pressure (BP), urinary albumin excretion (UAE), plasma Angiotensin II (Ang II), bradykinin and brain natriuretic peptide (BNP) were assessed at baseline and after 6, 12 and 24 weeks. Results: Both I and R produced a similar decrease in clinic, ambulatory and central BP (p < 0.001 vs baseline). Both treatments significantly reduced UAE throughout the study, but the decrease in UAE associated with I was more pronounced, being evident at week 6 (p = 0.05) and maximal at week 24 end-point (−42 vs –29%, p < 0.01). BNP and Ang II levels were similarly reduced by I and R, while bradykinin increased more with R (+132 vs +86%, p < 0.05). Conclusions: These findings showed that in diabetic hypertensive patients with microalbuminuria, despite equivalent BP-lowering effect, I produced a greater antiproteinuric effect than R, which might be due to different intrinsic molecular properties of the two drugs.
Permutation pattern matching

Cette these s'interesse au probleme de la recherche de motif dans les permutations, qui a pour objectif de savoir si un motif apparait dans un texte, en prenant en compte que le motif et le texte sont des permutations. C'est-a-dire s'il existe des elements du texte tel que ces elements sont tries de la meme maniere et apparaissent dans le meme ordre que les elements du motif. Ce probleme est NP complet. Cette these expose des cas particuliers de ce probleme qui sont solvable en temps polynomial.Pour cela nous etudions le probleme en donnant des contraintes sur le texte et/ou le motif. En particulier, le cas ou le texte et/ou le motif sont des permutations qui ne contiennent pas les motifs 2413 et 3142 (appele permutation separable) et le cas ou le texte et/ou le motif sont des permutations qui ne contiennent pas les motifs 213 et 231 sont consideres. Des problemes derives de la recherche de motif et le probleme de la recherche de motif bivinculaire sont aussi etudies.
Extensor digitorum brevis manus: Anatomical, radiological and clinical relevance: A Review

The extensor digitorum brevis manus (EDBM) is a supernumerary muscle in the dorsum of the hand frequently misdiagnosed as a dorsal wrist ganglion, exostosis, tendon sheath cyst or synovitis. Its presence in a living subject, confirmed by magnetic resonance imaging (MRI), is presented together with a review of the hitherto reported cases and the results of an anatomical study on 128 adult human cadavers (59 males and 69 females). The EDBM was found in three (2.3%) of the 128 cadavers. It occurred in two (3.4%) of the 59 male cadavers (one bilateral and one unilateral on the right side) and in one (1.5%) of the 69 female cadavers (unilateral on the left side). Consequently, the EDBM was found in four (1.6%) of the 256 upper limbs. It originated from the dorsal wrist capsule within the compartment deep to the extensor retinaculum for the extensor digitorum and inserted into the extensor hood of the index finger in one case and into that of the middle finger in three cases. In both hands of the living subject, the origin was similar but the insertion was into the index and middle fingers. In all cases, it was innervated by the posterior interosseous nerve and its blood supply was provided by the posterior interosseous artery. Clin. Anat. 15:286–292, 2002. © 2002 Wiley‐Liss, Inc.
Parkinsonism Signs and Symptoms in Agricultural Pesticide Handlers in Washington State

ABSTRACT Objectives: Examine associations between pesticide exposure and signs or symptoms of parkinsonism. Methods: Prior to the 2014 pesticide spray season, the authors examined 38 active pesticide handlers aged 35 to 65 (median: 43.5) who participated in the State of Washington’s cholinesterase monitoring program in the Yakima Valley, where cholinesterase-inhibiting insecticides are applied in fruit orchards. A movement disorder specialist assessed the workers using the Unified Parkinson’s Disease Rating Scale (UPDRS) motor subscore 3 (UPDRS3). Participants also self-reported work and medical histories, including the UPDRS activities of daily living subscore 2 (UPDRS2). The authors explored the relation between these scores and lifetime occupational pesticide exposure while accounting for age. Results: All participants were Hispanic men born in Mexico who had worked in agriculture for 4 to 43 years (median: 21 years, including 11 years applying pesticides, mostly in the United States). Ten participants (26%) reported difficulty with one or more UPDRS2 activities of daily living (maximum = 2), and nine (24%) had a UPDRS3 >0 (maximum = 10). The most common symptom and sign, respectively, were excess saliva (n = 6) and action tremor (n = 5). UPDRS2 and UPDRS3 scores were unrelated to the number of years applying pesticides, but UPDRS3, especially action tremor, was positively associated with living on or by a farm. Conclusions: Symptoms and signs of parkinsonism were absent to mild in this small sample of active workers who apply cholinesterase-inhibiting insecticides in Washington State, USA. Future studies should be larger and examine older, retired workers with greater cumulative exposure to agricultural pesticides at work and home, including other types of agricultural pesticides.
Long-term survival and prognostic implications after coronary artery bypass grafting in Chinese patients with coronary artery disease

Objectives — This hospital-based study was conducted to determine the survival rates of patients after coronary artery bypass grafting (CABG) surgery and the associated prognostic factors related to all-cause mortality during a 7-year follow-up in Taiwan. Methods and results — Between January 1997 and December 2003, the medical records of 1877patients who underwent primary, isolated CABG surgery were studied. The Kaplan-Meier method was used to estimate survival. Multiple Cox regression was used to investigate the independence of prognostic factors associated with all-cause mortality. Of the 1877patients who underwent CABG surgery, 192 expired during the 7-year study period. The overall patient survival rate was 85.96% (95% CI: 83.74-88.16). Using multiple Cox regression analysis, in addition to female gender, older age at surgery, pulmonary oedema, longer ischaemic time, longer cardiopulmonary bypass time, and poorer postoperative left ventricular ejection fraction were significant factors associated with all-cause mortality for both men and women. Associated prognostic factors varied by gender. For men, smoking (RR=2.82, 95% CI: 1.06-4.16), respiratory failure (RR=6.88, 95% CI: 3.29-14.40) and cardiogenic shock (RR=4.04, 95% CI: 2.13-7.67) were significantly related to all-cause mortality, but not for women. Sepsis (RR=8.97, 95% CI: 1.19-19.81) and ICU stay (RR=1.03, 95% CI: 1.01-1.05) were significantly related to all-cause mortality among female patients only. Conclusions — Several gender-related differences were noted pertaining to all-cause mortality and the relationships between smoking, sepsis, respiratory failure, cardiogenic shock, and ICU stay.
E7080, a Multi–Tyrosine Kinase Inhibitor, Suppresses the Progression of Malignant Pleural Mesothelioma with Different Proangiogenic Cytokine Production Profiles

Purpose: Malignant pleural mesothelioma (MPM) is a biologically heterogeneous malignant disease with a poor prognosis. We reported previously that the anti–vascular endothelial growth factor (VEGF) antibody, bevacizumab, effectively inhibited the progression of VEGF-high-producing (but not VEGF-low-producing) MPM cells in orthotopic implantation models, indicating the need for novel therapeutic strategies to improve the poor prognosis of this disease. Therefore, we focused on the multi–tyrosine kinase inhibitor E7080 and assessed its therapeutic efficacy against MPM cells with different proangiogenic cytokine production profiles. Experimental Design: The efficacy of E7080 was assayed in orthotopic implantation of severe combined immunodeficient mouse models with three human MPM cell lines (MSTO-211H, NCI-H290, and Y-MESO-14). Results: With regard to proangiogenic cytokine production profiles, MSTO-211H and Y-MESO-14 cells were MPM cells producing high levels of fibroblast growth factor-2 and VEGF, respectively. NCI-H290 cells produced low levels of fibroblast growth factor-2 and VEGF compared with the other two cell lines. E7080 potently suppressed the phosphorylation of VEGF receptor-2 and FGF receptor 1 and, thus, inhibited proliferation of endothelial cells, but not that of the MPM cell lines, in vitro. Orthotopically inoculated MSTO-211H cells produced only thoracic tumors, whereas NCI-H290 and Y-MESO-14 cells also developed pleural effusions. Treatment with E7080 potently inhibited the progression of these three MPM cell lines and markedly prolonged mouse survival, which was associated with decreased numbers of tumor-associated vessels and proliferating MPM cells in the tumor. Conclusions: These results strongly suggest broad-spectrum activity of E7080 against MPM with different proangiogenic cytokine production profiles in humans. (Clin Cancer Res 2009;15(23):7229–37)
Multiple myeloma in cosmetologists.

In an hypothesis-generating activity, data in a population-based cancer registry were analyzed according to occupation and industry. The number of cases of multiple myeloma was found to be excessive for females in the occupation "cosmetologists, hairdressers and manicurists. " Race did not explain the excess. People in this occupation have potential exposure to a number of chemicals that produce mutations in bacteria. Studies should be done to investigate the hypothesis that these chemicals cause multiple myeloma in cosmetologists.
Ranking Terrorists in Networks: A Sensitivity Analysis of Al Qaeda's 9/11 Attack

All over the world intelligence services are collecting data concerning possible terrorist threats. This information is usually transformed into network structures in which the nodes represent the individuals in the data set and the links possible connections between these individuals. Unfortunately, it is nearly impossible to keep track of all individuals in the resulting complex network. Therefore, Lindelauf et al. (2013) introduced a methodology that ranks terrorists in a network. The rankings that result from this methodology can be used as a decision support system to efficiently allocate the scarce surveillance means of intelligence agencies. Moreover, usage of these rankings can improve the quality of surveillance which can in turn lead to prevention of attacks or destabilization of the networks under surveillance. The methodology introduced by Lindelauf et al. (2013) is based on a game theoretic centrality measure, which is innovative in the sense that it takes into account not only the structure of the network but also individual and coalitional characteristics of the members of the network. In this paper we elaborate on this methodology by introducing a new game theoretic centrality measure that better takes into account the operational strength of connected subnetworks. Moreover, we perform a sensitivity analysis on the rankings derived from this new centrality measure for the case of Al Qaeda’s 9/11 attack. In this sensitivity analysis we consider firstly the possible additional information available about members of the network, secondly, variations in relational strength and, finally, the absence or presence of a small percentage of links in the network. We also introduce a case specific method to compare the different rankings that result from the sensitivity analysis and show that the new centrality measure is robust to small changes in the data.
Examining the effects that manipulating information given in the change of shift report has on nurses' care planning ability.

AIM OF THE STUDY To investigate the effect that manipulating the style and content of the nurse change of shift report had on an individual's ability to plan patient care. BACKGROUND The nurse change of shift report occurs on most hospital wards at least two if not three times a day. However, little research exists examining how changing the style and information content of the shift report may affect an individual's ability to process the information they hear. It is suggested that how individuals structure their knowledge, in the form of schema, is an important consideration when examining how they process information. DESIGN This was an experimental study where two independent variables, report style (retrospective vs. prospective) and schema information (schema consistent vs. schema inconsistent) were compared in a factorial design. A convenience sample of 48 registered nurses from acute medical and acute surgical wards were randomly allocated to one of the four experimental conditions. Outcome measures included the amount of information that subjects accurately recorded and recalled from the shift report, together with their ability to plan patient care. RESULTS Results indicated that the type of report had a significant effect on an individual's ability to plan patient care, and type of information content on their ability to accurately record and recall the information they heard. CONCLUSIONS The implications of the results, both for schema theory as an explanation of nursing knowledge, and for the type of report which should be used in acute medical and acute surgical wards are discussed, together with the implications of the study for further research.
On the singularity-induced bifurcation theorem

The singularity-induced bifurcation theorem (SIBT) is extended in this note to quasi-linear singular ordinary differential equations. The hypotheses supporting this result are simplified and rewritten in terms of matrix pencils. This approach shows that the SIB follows from a minimal index change at the singularity. The use of a quasi-linear reduction leads to a simple statement of the SIBT for semiexplicit index-1 differential algebraic equations.
A pure nongestational ovarian choriocarcinoma in a 10‐year‐old girl: Case report and literature review

Nongestational ovarian choriocarcinoma (NGCO) is a rare form of malignancy, which is difficult to diagnose. We present a case of a 10‐year‐old girl diagnosed with pure nongestational ovarian choriocarcinoma. This patient responded well to conservative surgery and cisplatin‐based regimen chemotherapy. Approximately 38 authenticated cases of NGCO have been reported in the English published work to date in the world. We report here the clinical features, differential diagnosis, appropriate management and outcome of our case, together with analysis of the reported cases in the published work.
Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2-selective inhibitors in patients with rheumatoid arthritis.

BACKGROUND Interaction with platelet function by non-steroidal anti-inflammatory drugs (NSAIDs) is related to the inhibition of cyclo-oxygenase-1 (COX-1). In patients with rheumatoid arthritis (RA), only one of the COX-2-selective NSAIDs (nabumetone) has been demonstrated to spare platelet function partially. OBJECTIVE To compare the effects of the COX-2-selective inhibitor, meloxicam, with those of the non-selective NSAID, naproxen, on platelet function and thromboxane levels in RA patients. METHODS In this randomized, controlled, cross-over trial, 10 RA patients used meloxicam 7.5 mg bid and naproxen 500 mg bid, each during a 2-week period. Washout periods were applied. Before and after each 2-week period of NSAID intake, laboratory studies were performed. RESULTS Platelet aggregation was significantly less influenced, thromboxane levels were less inhibited (246 vs 117 pg/ml) and bleeding times were less prolonged with meloxicam than with naproxen (3.2 vs 2.3 min). Moreover, the results of all tests during meloxicam exposure were comparable with baseline values. CONCLUSION In RA patients, meloxicam, a representative of the selective COX-2 inhibitors, does not interfere with platelet function and thromboxane levels, in contrast with naproxen (a non-selective COX inhibitor).
Asian Economic and Social Society Toxic Effects of Cadmium ( Cd ) and Lead ( Pb ) on Growth and Productivity of Arachis Hypogaea ( L ) and Glycine Max ( L )

A study was conducted to determine the effects of different concentrations of cadmium and lead on the growth and productivity of Arachis hypogaea and Glycine max. Seeds were sown on soils irrigated with 0, 10, 20, 30 and 40ppm concentrations of cadmium and lead. Growth and productivity indices were recorded at the 8 th week of growth and the elemental contents of the seeds produced were determined using Atomic Absorption Spectrophotometer. The data generated were subjected to One-Way Analysis of Variance and Duncan Multiple Range Test. The results showed that both lead and cadmium treatments had toxic effects on various growth indices and productivity of Arachis hypogaea and Glycine max. Increasing the concentrations of the metals (lead and cadmium) to 40 ppm, significantly (p<0.05) decreased seed germination and number of leaves in both Arachis hypogaea and Glycine max as compared to Control. The filling potentials of the two plants were greatly reduced with increase in concentrations of cadmium and lead regimes. The seeds produced accumulated a lot of cadmium and lead and their concentrations in the seeds increased as the regime concentrations increased. This study has been able to show the risks/hazards of the consumption of groundnuts and cowpeas that are irrigated with effluents or wastewaters. It is recommended that soils polluted with Pb and Cd should not be used to raise these crops.
Deoxycholic Acid Blocks Vibrio cholerae OmpT but Not OmpU Porin*

OmpT and OmpU are general diffusion porins of the human intestinal pathogen Vibrio cholerae. The sole presence of OmpT in the outer membrane sensitizes cells to the bile component deoxycholic acid, and the repression of OmpT in the intestine may play an important role in the adaptation of cells to the host environment. Here we report a novel important functional difference between the two porins, namely the sensitivity to deoxycholic acid. Single channel recordings show that submicellar concentrations of sodium deoxycholate induce time-resolved blocking events of OmpT but are devoid of any effect on OmpU. The effects are dose-, voltage-, and pH-dependent. They are elicited by deoxycholate applied to either side of the membrane, with some asymmetry in the sensitivity. The voltage dependence remains even when deoxycholate is applied symmetrically, indicating that it is intrinsic to the binding site. The pH dependence suggests that the active form is the neutral deoxycholic acid and not the negatively charged species. The results are interpreted as deoxycholic acid acting as an open-channel blocker, which may relate to deoxycholic acid permeation.