Miracle-dz/UniFAR-FTUs huggingface dataset:
Ischaemic stroke in the young adult: clinical features, risk factors and outcome.

BACKGROUND Stroke is an important cause of morbidity and mortality in young adults, especially in developing countries. This study aimed to evaluate the clinical features, risk factors and outcome of ischaemic stroke in young adults aged 15-45 years. METHODS A retrospective review was done of the medical records of 177 patients seen in a tertiary referral centre in Thiruvananthapuram, Kerala between January 1988 and March 1994. RESULTS There were 135 males and 42 females with a mean (SD) age of 34.7 (8) years at onset of stroke. An aetiological categorization of stroke was obtained in 111 (63%) patients and it was uncertain or unknown in the rest. Athero-thrombotic stroke and cardio-embolic stroke occurred in 24% and 17%, respectively. Hypertension, smoking, hyperlipidaemia and athero-thrombotic stroke were significantly more prevalent in the 31-45 year age group compared to the 15-30 year age group. There was only one patient with postpartum intracranial sinovenous thrombosis. At a mean follow up of 7 months (range 1-62 months), 75% of the patients were independent or only mildly disabled. The case-fatality rate was 1%. CONCLUSION Ischaemic stroke in the young adult is more frequent in males. The aetiopathogenesis can be determined in the majority and the athero-thrombotic process predominates. The mortality is negligible and the functional outcome is good in most patients.
Risk factors for severe retinopathy of prematurity in premature infants: a single-center study.

OBJECTIVE To evaluate the incidence and risk factors for severe retinopathy of prematurity (ROP) in preterm infants. METHODS Between May, 2008 and May, 2011, a total of 957 preterm infants at 4-6 weeks of chronological age or 32 weeks of postmenstrual age underwent retinal evaluation by RetCamII in our center, and the data of infants with ROP in any stage were analyzed. RESULTS Among the 957 preterm infants, we found 86 (8.99%) infants to have ROP in different stages, including 60 (6.27%) with mild ROP and 26 (2.72%) with severe ROP. The birth weight and gestational age of the infants with severe ROP averaged 1 420.40∓328.64 g and 29.88∓1.67 weeks, as compared to 1 593.28∓339.30 g and 31.78∓2.53 weeks in those with mild ROP, respectively, showing a significant difference between the two groups (P<0.005). The significant variables for severe ROP included gestational age (P=0.001), birth weight (P=0.035), 1 min Apgar score (P=0.001), 5 min Apgar score (P=0.005), number of blood transfusions (P=0.032), and the presence of apnea (P=0.04) and retinal hemorrhage (P=0.000). Gestational age and retinal hemorrhage were the independent risk factors for severe ROP (OR=0.353, 95%CI 0.163-0.763, P=0.008; OR=26.133, 95%CI 3.042-224.501, P=0.035). CONCLUSION Severe ROP tends to have a decreasing incidence and occurs more often in more mature preterm infants. The affected infants have the characteristics of the first epidemics. Gestational age and retinal hemorrhage are independent predictive factors for severe ROP.
New nonlinear device model for microwave power GaN HEMTs

This paper presents a new nonlinear device model, for microwave power GaN HEMTs, amenable for integration into a commercial harmonic balance simulator. All the steps taken to extract it are explained, starting with the extrinsic elements' determination and ending with the intrinsic ones. This model was validated by comparing measured and simulated output power and intermodulation distortion data of a GaN HEMT. Very good agreement was obtained from small- to large-signal excitation regimes.
Quantum Monte Carlo study of the one-dimensional symmetric Kondo lattice.

We present numerical results for the one-dimensional symmetric Kondo lattice, obtained by using a lattice-fermion Monte Carlo algorithm in conjunction with recently developed low-temperature stabilization techniques. The results are extrapolated in imaginary-time increment and lattice size to obtain controlled estimates for various quantities in the thermodynamic limit. In particular, we compare spin correlations with Ruderman-Kittel-Kasuya-Yosida predictions and two-impurity data, and note the opening of a gap as the temperature is lowered. We next discuss certain properties of the frequency-dependent conductivity, and compare ground-state results with a strong-coupling expansion. We then perform a particle-hole transformation to obtain an attractive-{ital J}'' lattice and discuss the existence of superconductivity in such a model. Finally, we discuss the relevance of our results to various theoretical treatments of Kondo and Anderson lattice models.
İlkokulda Aritmetik Problemlerini Çözmede Etkili Görülen Bazı Faktörler

Matematikte problem cozmedeki basariyi degerlendirme yalnizca problemlerin cozumlerinin dogru veya yanlis olduguna bakmak ve dogru cozulen problemlerin sayisina veya durumuna gore ogrenciye deger bicmek degildir. Ozellikle ilkokulda ogrencilerin her adimda izlenmesi gerekir. Boyle bir dusunce, problem cozmede basarili ogrencilerin ozellikle gosterdikleri kritik davranislarin ortaya cikarilmasi, basarisiz olanlarin ise bu davranislardan hangilerini daha cok gostermedikleri veya kritik davranislardan hangilerinin bu ogrencilerde olusmamis oldugunun ortaya konulmasini gerektirir. Ayrica bu yaklasim problemlerin cozumleriyle ilgili temel kavramlari, ilkeleri ve hesaplama gibi zihinsel becerilerin de ogrencilerde yoklanmasini zorunlu kilar. Boyle bir yaklasim ozellikle temel becerilerin gelistigi ilkokul duzeyinde buyuk onem tasir.
Phytoplasmas and disease symptoms of crops and weeds in the semi-arid tropics of the Northern Territory, Australia

This study used molecular techniques to investigate the little-known characteristics of phytoplasmas in the semi-arid tropics of northern Australia in sesame, mung bean and peanut crops, and in adjacent non-crop species. Five new records of plant species associated with phytoplasma diseases are reported. No phytoplasmas were associated with fasciation but four phytoplasma strains were linked with other symptoms. Sweet potato little leaf variant Vinca 4, the most prevalent phytoplasma, was associated with symptoms of little leaf, or little leaf and phyllody, in all hosts (crop and non-crop species) except sesame, where it was most often associated with floral dieback. Tomato big bud was found only in sesame showing phyllody. Pigeon pea little leaf occurred in one mung bean and one peanut plant with little leaf and phyllody, and one non-crop species with yellowing and rosette formation. Waltheria little leaf was found in a single non-crop individual with little leaf and bunching symptoms. The findings show that adjacent non-crop species have the potential to function as reservoirs of phytoplasma disease for crop species but symptoms alone are not sufficient to diagnose specific phytoplasma strains.
Evidence of vagus nerve sprouting to innervate the urinary bladder and clitoris in a canine model of lower motoneuron lesioned bladder

Complete spinal cord injury does not block perceptual responses or inferior solitary nucleus activation after genital self‐stimulation, even though the vagus is not thought to innervate pelvic structures. We tested if vagus nerve endings sprout after bladder decentralization to innervate genitourinary structures in canines with decentralized bladders.
Alteration of peripheral blood dendritic cells in patients with primary Sjögren's syndrome.

OBJECTIVE We recently identified 3 fractions of human peripheral blood (PB) dendritic cells (DC), including the monocyte-associated fractions 1 and 2 (CD1a+,CD11c+ and CD1a-,CD11c+, respectively) and the lymphoid-associated fraction 3 (CD1a-,CD11c-). We attempted to determine whether these fractions were altered in Sjögren's syndrome (SS). METHODS We examined 23 patients with primary SS and 22 normal control subjects. DC were purified from PB and analyzed by flow cytometry. Immunohistochemical staining of labial salivary glands of SS patients was performed with monoclonal antibodies against fascin, which is known to be specific for DC. RESULTS The total numbers of PB DC and fraction 1 DC were decreased in SS. Immunohistochemical staining demonstrated that fascin+,CD11c+,HLA-DR+ mononuclear cells were present and scattered among numerous fascin-hyperfiltrating cells in SS patients. Interferon-gamma (IFNgamma)-producing Th1 cells were shown to be increased in both PB and salivary glands of patients, indicating the presence of general IFNgamma-producing Th1 polarization in SS. Furthermore, numbers of Thl cells were increased when naive T cells were cocultured with fraction 1 DC in vitro. CONCLUSION These findings suggest selective trafficking of fraction 1 DC into focal sites of inflammation and subsequent promotion of Th1 balance, suggesting a novel pathogenesis of SS.
The Herbicide Metolachlor Induces Liver Cytochrome P450s 2B1/2 and 3A1/2, but Not Thyroxine-Uridine Dinucleotide Phosphate Glucuronosyltransferase and Associated Thyroid Gland Activity

Metolachlor (2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl) acetamide) is widely used internationally as a corn and cotton herbicide. The metolachlor effects noted in rats during testing for U.S. pesticide registration include increased liver weight and hepatocarcinogenicity associated with eosinophilic foci. These properties, plus nongenotoxicity, are also characteristic of the prototypical rat liver tumor promoter, phenobarbital. Phenobarbital induces hepatic cytochrome P450s CYP2B1/2 and CYP3A1/2 and thyroxine (T4)-UDP-glucuronosyltransferase (T4-UGT), which enhances thyroxine clearance and thus indirectly increases thyroid gland activity. Because other chloroacetanilide herbicides are known to similarly affect rat thyroid gland, this study tested the hypothesis that metolachlor would have these additional phenobarbital-like effects on liver, especially that of T4-UGT induction with consequential stimulation of thyroid gland. Effects of metolachlor, fed to male Sprague-Dawley rats for 14 days at the carcinogenic dose of 3000 ppm, were compared to those of equimolar phenobarbital. Liver microsomal CYP2B1/2 and CYP3A1/2 were probed by immunoblotting and T4-UGT was measured enzymat-ically. Serum T4, triiodothyronine (T3), and thyroid-stimulating hormone (TSH) and thyroid follicular epithelial cell morphology and proliferation were used to assess thyroid gland activity. Metolachlor induced CYP2B1/2 and CYP3A1/2 proteins, but unlike phenobarbital, did not affect T4-UGT activity. In agreement, serum T4, T3, or TSH were unaffected by metolachlor. Also, no significant effects of metolachlor on thyroid gland morphology or follicular epithelial cell height or proliferation were observed. These data demonstrate that metolachlor is an inducer of hepatic CYP2B1/2 activity. But unlike the prototypical CYP2B1/2 inducer phenobarbital, metolachlor does not cause an increase in T4-glucuronidation and thyroid gland activation.
Pellagra, a study in human nutrition; the multiple-factor principle of the determination of minimum vitamin requirements.

ROM a study of the relation of the diet as a whole to ·the minimum requirement of dietary nicotinic acid, the subject matter of this paper has been derived. It is based upon an analysis of the many data on the experimental production and cure of pellagra which have accumulated during the past thirty years. These carefully collected dietary records, accompanied by clinical ob£ervations, are valuable because they indicate not only the minimum requirement of nicotinic acid, but they also point to an interrelation between the levels of intake of nicotinic acid, good quality proteins and other food factors. Although pellagra had undoubtedly affected man in previous ages, it did not attract attention until the introduction of maize in the dietary of western civilizat ion more than 200 years ago. Several theories as to its etiology have been proposed since the disease was first described by Gasal in 1735 (1) . The very voluminous literature concerning these theories has been so well reviewed by others that we shall only mention the three general categories into which they fall: (a) the maize theory, that pellagra results from a high consumption of corn, especially of spoiled corn ; (b) the infectious theory, that pellagra is due to an infectious agent; (c) the dietary de-
Primary Hodgkin's lymphoma of the esophagus.

The esophagus is the least commonly involved gastrointestinal organ, accounting for fewer than 1% of patients with lymphoma. Such involvement is mostly secondary, from mediastinal lymph nodes or gastric lymphoma. The primary form arises from the esophageal wall itself and occurs much less frequently. Primary esophageal lymphoma is mostly seen in male patients with Hodgkin's disease. A primary non-Hodgkin's lymphoma of the esophagus with concomitant involvement of the bone marrow is presented, and imaging features of esophageal lymphoma are reviewed.
SEROLOGIC SURVEY OF DOMESTIC FELIDS IN THE PETÉN REGION OF GUATEMALA

Abstract Blood samples were analyzed from 30 domestic cats (Felis domesticus) from the Petén region of Guatemala to determine the seroprevalence of common pathogens that may pose a potential risk to native wild felids. Eight of the cats had been vaccinated previously; however, owners were unable to fully describe the type of vaccine and date of administration. In addition, blood samples were obtained from two captive margays (Leopardus wiedii). Samples were tested for antibodies to feline immunodeficiency virus, Dirofilaria immitis, feline panleukopenia virus, feline herpesvirus, feline coronavirus, canine distemper virus, and Toxoplasma gondii and for feline leukemia virus (FeLV) antigen. Fifty percent or more of the cats sampled were seropositive for feline herpesvirus (22 of 30), feline panleukopenia (15 of 30), and T. gondii (16 of 30). Five cats were positive for FeLV antigen. Both margays were seropositive for feline coronavirus and one was strongly seropositive to T. gondii. All animals were seronegative for D. immitis. This survey provides preliminary information about feline diseases endemic to the Petén region.
New coplanar-like transmission lines for application in monolithic integrated millimeter-wave and submillimeter-wave circuits

In monolithic microwave integrated circuits (MMICs) for application at millimeter-wave and submillimeter-wave frequencies, new transmission lines with low loss and low dispersion are needed. An additional requirement is that these transmission lines can be produced using conventional MMIC technology. In this paper two new coplanar-like transmission lines which fulfil the above mentioned requirements are analyzed using a finite difference time domain (FDTD) analysis and a quasi-static finite difference method (FD). It will be shown that transmission lines with a low value of the effective dielectric constant, with low dispersion and low losses can be easily produced.
The cortical projections of foveal striate cortex in the rhesus monkey.

1. The cortical projections of the foveal and extrafoveal parts of the striate cortex have been compared, using conventional degeneration techniques, as well as combinations of anatomical methods. While both foveal and extrafoveal striate cortex share a common pattern of projections (to areas V2, V3 and the visual area in the medial part of the posterior bank of the superior temporal sulcus), foveal striate cortex was found to have an additional projection (to part of the cortex of the fourth visual areas, V4). The latter projection includes the posterior lip of the inferior occipital sulcus which, on anatomical grounds, is regarded as the ventral extension of V4. 2. Anatomical studies using double tracers were employed to clarify the nature of the projections from the striate cortex and from V2 to V4. In one such experiment, tritiated proline was injected into extra‐foveal striate cortex and a small lesion was made in that part of V2 receiving a direct projection from the region of the striate cortex into which the radioactive tracer was injected. Only degenerating fibres (due to the lesion), and no radioactive label, was found in V4. Such an experiment showed that, unlike foveal striate cortex, the projections from extrafoveal striate cortex to V4 are not direct, but through V2. 3. In another type of anatomical experiment using double tracers, the corpus callosum was sectioned and tritiated proline was injected into foveal striate cortex. Such an experiment allowed a more accurate determination of the extent of V4, as judged from its callosal connexions, to which foveal striate cortex projects. 4. Considering the projections of V1 to areas V2, V3 and the visual area in the medial part of the posterior bank of the superior temporal sulcus, and considering the differences in the projections of foveal and extrafoveal striate cortex, it is suggested that, among other functions, the striate cortex acts as a distribution centre for the information coming over the retino‐geniculo‐cortical pathways, parcelling this information out to different visual areas of the prestriate cortex for further analysis.
Lung cancer death rates in lifelong nonsmokers.

BACKGROUND Few studies have directly measured the age-, sex-, and race-specific risks of lung cancer incidence and mortality among never tobacco smokers. Such data are needed to quantify the risks associated with smoking and to understand racial and sex disparities and temporal trends that are due to factors other than active smoking. METHODS We measured age-, sex-, and race-specific rates (per 100,000 person-years at risk) of death from lung cancer among more than 940,000 adults who reported no history of smoking at enrollment in either of two large American Cancer Society Cancer Prevention Study cohorts during 1959-1972 (CPS-I) and 1982-2000 (CPS-II). We compared lung cancer death rates between men and women and between African Americans and whites and analyzed temporal trends in lung cancer death rates among never smokers across the two studies by using directly age-standardized rates as well as Poisson and Cox proportional hazards regression analyses. All statistical tests were two-sided. RESULTS The age-standardized lung cancer death rates among never-smoking men and women in CPS-II were 17.1 and 14.7 per 100,000 person-years, respectively. Men who had never smoked had higher age-standardized lung cancer death rates than women in both studies (CPS-I: hazard ratio [HR] = 1.52, 95% confidence interval [CI] = 1.28 to 1.79; CPS-II: HR = 1.21, 95% CI = 1.09 to 1.36). The rate was higher among African American women than white women in CPS-II (HR = 1.43, CI = 1.11 to 1.85). A small temporal increase (CPS-II versus CPS-I) in lung cancer mortality was seen for white women (HR = 1.25, CI = 1.12 to 1.41) and African American women (HR = 1.22, CI = 0.64 to 2.33), but not for white men (HR = 0.89, CI = 0.74 to 1.08). Among white and African American women combined, the temporal increase was statistically significant only among those aged 70-84 years (P < .001). CONCLUSIONS Contrary to clinical perception, the lung cancer death rate is not higher in female than in male never smokers and shows little evidence of having increased over time in the absence of smoking. Factors that affect the interpretation of lung cancer trends are discussed. Our novel finding that lung cancer mortality is higher among African American than white women never smokers should be confirmed in other studies.
Experimental exposure to methyl tertiary-butyl ether. II. Acute effects in humans.

Methyl tertiary-butyl ether (MTBE) is widely used in gasoline as an oxygenate and octane enhancer. Acute effects, such as headache, nausea, and nasal and ocular irritation, have been associated with the exposure to gasoline containing MTBE. The aim of this study was to assess acute health effects up to the Swedish occupational exposure limit value, both with objective methods and a questionnaire. Ten healthy male volunteers were exposed to MTBE vapor for 2 h at three levels (5, 25, and 50 ppm), during light physical work (50 W). All subjects rated the degree of irritative symptoms, discomfort, and CNS effects before, during, and after all three exposure occasions using a questionnaire. Answers were given on a 100-mm visual analog scale, graded from "not at all" to "almost unbearable. " Ocular (redness, tear film break-up time, self-reported tear film break-up time, conjunctival epithelial damage, and blinking frequency) and nasal (mouth and nasal peak expiratory flow, acoustic rhinometry, biochemical inflammatory markers, and cells in nasal lavage) measurements were performed mainly at the highest exposure level. The ratings of solvent smell increased dramatically (ratings up to 50% of the scale) as the volunteers entered the chamber and declined slowly with time (p < 0.05, repeated-measures ANOVA). All other questions were rated from "not at all" to "hardly at all" (0-10% of the scale) with no significant relation to exposure. The eye measurements showed no effects of MTBE exposure. Blockage index, a measure of nasal airway resistance calculated from the peak expiratory flows, increased significantly after exposure; however, the effect was not related to exposure level. In addition, a nonsignificant tendency of decreased nasal volume was seen in the acoustic rhinometry measurements, but with no clear dose-effect relationship. In conclusion, our study suggests no or minimal acute effects of MTBE vapor upon short-term exposure at relatively high levels.
Cyclically Neutral Generational Accounting

This paper introduces a methodological innovation into Generational Accounting. By incorporating cyclically-adjusted balances into the forward-looking budget projections underlying the concept we isolate pure policy effects, which render comparisons of the fiscal sustainability indicators obtained across time and countries truly meaningful. We also show that a demographic effect and a debt effect may bias fiscal sustainability measures over time, and establish a routine to control for these effects in the generational accounting framework. An empirical application for Spain illustrates that our proposed decomposition of indicators is empirically relevant. Standard generational accounting suggests that fiscal sustainability in Spain improved substantially in preparing for EMU. However, calculation of the pure policy effects reveals that this has not been the case.
PEAK FACTOR FOR NON-GAUSSIAN PROCESSES REVISITED

This paper discusses non-Gaussian peak factor for univariate stationary non-Gaussian processes, which can be used for estimating expected positive and negative extremes of non-Gaussian processes, e.g., a time history of wind pressure fluctuations in separated flow regions like the roof of a low-rise building. A previous analytical expression for the peak factor for non-Gaussian processes given in [Kareem and Zhao (1994)] based on a moment-based Hermite model is revisited and the standard deviation of this estimate is derived. In addition, some improvements concerning the estimation of the peak factor are discussed. Examples illustrate the efficacy of this data-driven model-based peak factor approach.