Miracle-dz/UniFAR-FTUs huggingface dataset:
Roles of MALAT1 in development and migration of triple negative and Her-2 positive breast cancer

Background As a type of new targets for prognosis of malignancies, long non-coding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcription 1) is associated with proliferation and metastatic abilities of several malignancies. However, its relations to development and migration of triple negative and human epidermal growth factor receptor 2 (Her-2) positive breast cancers haven't been reported. Objectives In this paper, we aimed to discuss how MALAT1 is connected with and affects proliferation and invasion abilities of cells in Her-2 positive and triple-negative breast cancers (TNBC). Methods The expression of MALAT1 in clinical samples with TNBC and Her-2 positive breast cancers was tested by qRT-PCR. The statistical analysis was performed to unveil the potential relationships between the expression of MALAT1 and prognostic factors of breast cancer such as OS (overall survival), RFS (relapse-free survival), number of metastatic lymph nodes and pTNM staging in patients with TNBC or Her-2 positive breast cancer. MALAT1 and XBP1 were knockdown respectively in Her-2 positive cell line MDA-MB-231, and MALAT1 and Her-2 were knockdown respectively in TNBC cell line MDA-MD-435 using siRNA. The alterations of expressions of MALAT1 and related genes were detected by qRT-PCR in two breast cancer cell lines. The changes of proliferation abilities in two cell lines were observed using CCK8 assays. Furthermore, transwell assays were performed to detect changes to invasion abilities of the cells. Results The expression of MALAT1 in triple negative and Her-2 positive breast cancers was positively correlated to the number of metastatic lymph nodes in patients with breast cancer. MALAT1 promotes proliferation and invasion abilities of breast cancer cells through XBP1 (X-box binding protein 1)-HIF (hypoxia-inducible factor)-1α pathway in MDA-MB-231 and through Her-2 pathway in MDA-MD-435. Moreover, MALAT1 could possibly be involved in regulation of MYC gene and CD47 (an immune checkpoint gene) in both cell lines. Conclusions Our study suggested that MALAT1 is a core signaling molecule for promoting development and migration of triple negative and Her-2 positive breast cancers. It would be employed as common markers for prognosis of the two types of breast cancer mentioned above and potential targets for treating them.
Validity and Reliability of the Short Form- 36 Items Questionnaire as a Measure of Quality of Life in Elderly Iranian Population

The utility of The SF-36 questionnaire for evaluation of health related quality of life was not clear in elderly people. The Cross-Sectional study was designed and Iranian version of The SF-36 was administered to random sample of 100 old subjects over 60 years old. Finding showed good internal consistency over 0.7 for all subscales of questionnaire. Convergent validity was obtained for all subscales with comparison for General Health Questionnaire-28 (GHQ-28) but was not strongly at 2 subscales Role emotional and Role physical. Discriminant validity was addressed for gender but for age groups role emotional, mental health and general health subscales were not different significantly. A principal component analysis was leaded one factor structure. Evidence for reliability of the questionnaire was good. But validity appeared moderate satisfactory. However this questionnaire seems the only measure for assessment of health related quality at life among elderly population.
Effects of Heavy Metals on Soil Enzymatic Activities in the Ishiagu Mining Area of Ebonyi State-Nigeria.

Effects of heavy metal pollution on the enzymatic activities of soils were investigated in the Ishiagu mining area of Ebonyi State, Nigeria. Soil dehydrogenase, polyphenol oxidase, hydrogen peroxidase, alkaline and acid phosphatases and urease were measured to evaluate the effects of heavy metals mining operations on soil biochemical characteristics. Results showed that the soil pH ranged from 5.04 to 6.56 while the heavy metals were of the ranges: Pb (13,754-29,491 mg/kg), Zn (1,151-2,778 mg/kg), Cd (17.65-27.71 mg/kg), Cu (9.59-39.91 mg/kg) and total heavy metals (014,932.24-32,336.62 mg/kg). Soil heavy metals concentrations significantly decreased with the increase of distance from the mining pit while soil pH increased with the increase of the distance from the mining pit. Analysis of the soil enzyme activities indicated a significant positive correlation at P≤ 0.05 between soil enzyme activities and soil pH. On the contrary, the activities of dehydrogenase, polyphenol oxidase, hydrogen peroxidase, alkaline and acid phosphatases and urease showed significant negative correlation at P≤ 0.05 with the heavy metal contents except for Zn against dehydrogenase activity and Cd against hydrogen preoxidase and urase activities that were though negative but statistically not significantly correlated at P≤ 0.05. This showed that the activities of the enzymes analysed could be used as sensitive indicators of heavy metals contamination. The results in general indicated that the mining operations at Ishiagu, Ebonyi State affect the soil quality due to heavy metal contamination.
Impact of hot carrier stress on small-signal parameters of FD-SOI NMOSFETs

The continuous evolution and physical scaling of RF CMOS devices empowers the high performance millimeter wave applications of modern technologies. The reliable operation of these devices is also becoming more and more important with the rapid scaling to achieve higher performance. To obtain in depth understanding of reliability of FD-SOI RF devices, the worst case hot carrier stress was induced and the corresponding impact on small signal parameters is analyzed using S-parameter and DC measurements. The physical origin of the variation and the link with DC parameter degradation is investigated.
Modelling and Simulation for Performance Evaluation of IEC61850-Based Substation Communication Systems

With the publishing of IEC 61850, the global communication standard for substation automation system (SAS), interoperability issue between intelligent electronic devices (IEDs) from different venders has been resolved. However, the overall performance and extensibility of this communication network are still left unanswered. This paper introduces the modeling technique of IED generic models and the setup of a research platform for resolving those issues using the OPNET Modeler. These configurable IED models allow the engineers to easily build SAS network model with different topologies for all kinds of substations so that the dynamic performance issues could be studied and rules could be developed to guide the SAS network planning and design. Some examples of using those models to construct SAS network as well as the network performance simulation results are also included in this paper.
FREQUENCY OF ISOLATION OF STAPHYLOCOCCUS INTERMEDIUS FROM CANINE PYODERMA AND ITS ANTIBIOGRAM PATTERN

A total of 77 skin swabs from canine pyoderma were subjected for culture and antibiogram. The Staphylococcus intermedius was isolated (60 %) along with other bacteria and fungi. It showed sensitivity to amikacin-72%, ciprofloxacin- 60%, gentamicin-56%, amoxicillin- clavulanic acid-54% and complete resistance to ampicillin. The medical records analysis evidenced that the isolates (5%) showed resistant to all antimicrobial drugs were from cases with recurrent pyoderma.
Is the voice an auditory face? An ALE meta-analysis comparing vocal and facial emotion processing

Abstract This meta-analysis compares the brain structures and mechanisms involved in facial and vocal emotion recognition. Neuroimaging studies contrasting emotional with neutral (face: N = 76, voice: N = 34) and explicit with implicit emotion processing (face: N = 27, voice: N = 20) were collected to shed light on stimulus and goal-driven mechanisms, respectively. Activation likelihood estimations were conducted on the full data sets for the separate modalities and on reduced, modality-matched data sets for modality comparison. Stimulus-driven emotion processing engaged large networks with significant modality differences in the superior temporal (voice-specific) and the medial temporal (face-specific) cortex. Goal-driven processing was associated with only a small cluster in the dorsomedial prefrontal cortex for voices but not faces. Neither stimulus- nor goal-driven processing showed significant modality overlap. Together, these findings suggest that stimulus-driven processes shape activity in the social brain more powerfully than goal-driven processes in both the visual and the auditory domains. Yet, whereas faces emphasize subcortical emotional and mnemonic mechanisms, voices emphasize cortical mechanisms associated with perception and effortful stimulus evaluation (e.g. via subvocalization). These differences may be due to sensory stimulus properties and highlight the need for a modality-specific perspective when modeling emotion processing in the brain.
Asymmetric Effects of Oil Prices on the Manufacturing Sector in Turkey

We investigate the relationship between oil prices and manufacturing sector of a small open economy, Turkey. We take into account exogeneity of oil prices, extreme oil-reliance and import-dependence, as well as asymmetric responses of oil product prices to world crude oil price changes. We also control for the global liquidity and domestic finance conditions, along with real exchange rate dynamics in our VAR estimations. We report that while oil price increases do not significantly affect the manufacturing sector in aggregate terms, some sub-sectors are adversely affected.
Patency of Autologous Reverse Great Saphenous Vein Versus Polytetrafluroethylene in Below Knee Femoro popliteal Bypass Grafting

Correspondence: Dr. Rashid Usman 1* Department of Vascular Surgery Combined Military Hospital Lahore Cantt E mail: drrashidusman@yahoo.com INTRODUCTION: First ever bypass grafting for peripheral vascular occlusive disease was performed by Kunlin in 1949 using an autologous saphenous vein as a conduit. Since then many studies were performed to find out the best possible material for bypass grafting as venous conduit may not be always available. Most of the studies suggested saphenous vein as the best conduit for infragenicular bypasses. 6 Considering the refinement in the prosthetic material A B S T R A C T
Impact of Teacher-Gender on Primary Students' Achievement: A Study at Malaysian Standpoint

This study attempts to find the impact of teacher-gender on primary student achievement. The quantitative method of research was used for this study. This study, first in its nature in Malaysia, uses test scores of primary grades for five consecutive years which is obtained from a school in Kuala Lumpur. This study engages a total of 1 school, 20 classes, 30 teachers and 604 students. The overall finding in this study is that women are slightly better to teach in primary when the test scores are analyzed. Although there are some differences in the breakdown analysis, the combined result analysis do not find strong evidence to claim whether students have to be taught by teachers of same or alternative gender. The findings of this study provide important information for the policy makers and especially for the primary teachers’ recruiters in primary schools of Malaysia.
Analysing the influence of the DCBF data structure on the DoS attack detection

One of the most common threats to internet security is the Denial of Service attack. There are numerous methods and protocol changes in an effort to detect them. The most common DoS attack detection method relies on the number of the TCP control packet in the network flow. The Bloom filter represents a space efficient data structure that is commonly utilized to detect matching pairs. There are multiple algorithms for the DoS attack detection based on the Bloom filter. The SACK2 algorithm uses the SYN/ACK — ACK matching pair detection with the Bloom filter data structure. The false positive error introduced by the Bloom filter influences on the matching pair detection in the algorithm. The improved SACK2 algorithm significantly reduces the false positive error by replacing the Counting Bloom Filter (CBF) data structure with the Dual Counting Bloom Filter (DCBF) data structure. This improvement significantly improves the matching pair detection. It is expected that the false positive error should influence on the detection of the DoS attack. In this paper, the experimental study is performed to analyse this influence. This study confirms the correlation between the false positive error and the DoS attack detection.
Socratic Teachers and Confucian Learners: Examining the Benefits and Pitfalls of a Year Abroad

This paper explores the interplay between Western conceptions of education and students from other educational traditions, most specifically Japan, through the lens of the author's practice in international education. He examines models of the private and public spheres and public discourse advanced by Hannah Arendt and Jurgen Habermas in relation to the purpose of education, and discusses the transferability of these concepts to cross-cultural contexts, through an analysis of the nature of the public and the private in Japanese society. Finally, the paper urges international educators to take responsibility for the message they send exchange students by providing the mediation necessary to put their exchange experience into the proper context.
Review in Muscle Nerve Genetics and pathogenesis of malignant hyperthermia

Malignant hyperthermia (MH) is manifest in response to anesthetic triggering agents with symptoms of sustained uncontrolled skeletal muscle contracture, hypermetabolism, rapid increase in body temperature, rhabdomyolysis, and cardiac arrhythmia. Susceptibility to MH, an autosomal dominant trait, may be associated to congenital myopathies, but in the majority of the cases, no clinical signs of disease are visible outside of anesthesia. For diagnosis, a functional test on skeletal muscle biopsy, the in vitro contracture test (IVCT), is performed. Over 50 % of the families show linkage of the IVCT phenotype to the gene encoding the skeletal muscle ryanodine receptor and over 20 mutations therein have been described. At least 5 other loci have been defined implicating greater genetic heterogeneity than previously assumed, but so far only one further gene encoding the main subunit of the voltage-gated dihydropyridine receptor was found to be associated to MH. Thanks to extensive research on mechanisms of excitation contraction coupling and recent functional characterization of several disease-causing mutations in heterologous expression systems, much is known today about the molecular etiology of the disorder.
Bi-Directional Faraday Rotation Selective Enhancement on Embedded Nano-Gratings

The magneto-optic rotation enhanced by plamonic resonance brought a new method in the research of magnetoplasmon and magneto-optical devices. To further the availability of this method, the Faraday effect on embedded nano-gratings with Bi-substituted yttrium iron garnet substrate is investigated here to achieve bi-directional rotation enhancement selectively. The surface of the simulation structure is designed as 1-D gratings to excite extraordinary optical transmission, and the transmitted light is rotated in the magneto-optic (MO) material. It is found that the characteristic of the bi-directional Faraday rotation enhancement can be greatly influenced by the embedding depth of the metal strips in the MO material. According to this, without changing the applied magnetic field or turning over the MO material, the selectively enhanced Faraday rotation is produced along two opposite directions. Moreover, by optimizing the thickness of metal, a great improvement of figure of merit is obtained. Finally, in the same wavelength regime, the properties of the structure are contrasted when the metal is set to be gold or silver, respectively. This letter provides a useful thought in magnetoplasmon studies, and can be used to fabricate many magneto-optical devices.
Fast all-optical 10 Gb/s NRZ wavelength conversion and power limiting function using hybrid InP on SOI nanocavity

A new optical switch is presented using InP/SOI hybrid photonic crystal nanocavity. Switching contrast of 11 dB with 20 mW peak power and recovery time of 14 ps are measured. NRZ wavelength conversion and power limiter are demonstrated at 10 Gb/s through system experiments with 6 and 1 mW peak power respectively.
Internal Marketing , Job Satisfaction and Service Quality : A Study of Higher Education Institutions of Pakistan

This paper explores the element of internal marketing that impact job satisfaction and service quality of faculty members employed in public and private universities in Pakistan. Our sample consists of 372 faculty members. The results provide evidence that all of internal marketing elements (empowerment, recognition, employee motivation & market orientation) have significant effect on job satisfaction. Empowerment and motivation have significant effect on service quality, while market orientation and recognition have no significant effect on service quality. On the other hand job satisfaction has strong effect on service quality indicating the importance of this relationship. This study is a pioneering effort to explore the role of internal marketing in an emerging economy. The results could guide mangers of universities in enhancing job satisfaction and service quality, leading to improved employee performance and student satisfaction.
Electrolyte Level Changes in Acute Myocardial Infarction Patients as Compared to Healthy Individuals in Khan Younis Governorate, Gaza Strip

Acute myocardial infarction (AMI) is one of the leading causes of morbidity and mortality across the world. Serum electrolytes changes in AMI have not been studied in Khan Younis Governorate-Palestine. Hence, this study was undertaken to investigate any changes in the serum electrolytes with special attention to serum sodium, potassium, calcium, magnesium and chloride in cases of AMI. Aim: To determine the pattern of changes of serum electrolytes AMI patients and then compare with non AMI (i.e. healthy persons). Materials and Method: The study consisted of a hundred people divided equally into study group and control group. Samples were taken from the Central Heart Unit in Nasser Hospital - Khan Younis. The study group comprised cases of confirmed diagnosis of recent onset of AMI. Clinical data was collected using interviewing questionnaires. The first paragraph of the questionnaire was for personal data which included age, sex and education level. The blood samples of both groups were automatically analyzed for serum electrolytes (Na + , K + , Cl - , Ca + and Mg + ) where the latter was analyzed manually. The cases were taken from AMI patients within 48 hours of admission. Results: The mean of age of controls was 47.18±64 while that of cases was 56.34±12.84. Significant low level of calcium was found in AMI patients while the level observed for magnesium was high. The levels of potassium and magnesium in AMI patients with hypertension was observed to be low with p-value < 0.05. Moreover, potassium levels were also low in AMI patients with diabetes with p-value <0.05. The changesin electrolytes werenot statistically significant in association with smoking. Conclusion: The decrease in sodium level was observed only in patients with AMI compared with healthy persons.
Screening for psychiatric symptoms in a general outpatient clinic in Lagos, Nigeria: Th e need for a psychiatric evaluation

Previous empirical studies indicated that a significant number of patients seen at the general outpatients department (GOPD) present with various types of common mental disorders. The comorbidity between psychopathologies such as anxiety, depression, psychological distress, and physical disorders have also been published previously [1,2]. These mental health conditions have been reported to make significant contribution to the burden of disease and disability in the low and middle-income countries and were observed to be responsible for about 13% of total global disease burden [3,4]. Published evidence showed that 20-45% of visitations to the primary care clinics were attributed to mental health disorders [5,6]. However, the inabilities and difficulties encountered by medical officers and family physicians at the GOPD and primary healthcare settings in recognizing these psychopathologies have also been documented [7,8]. The identified factors found to be responsible for the inability of primary healthcare clinicians Screening for psychiatric symptoms in a general outpatient clinic in Lagos, Nigeria: Th e need for a psychiatric evaluation
Learning in Cognitive Niches

In 2002, the first season’s first episode of the Brazilian TV series City of Men, named “The Emperor’s Crown”, began with a scene of a History lesson in a public school of Rio de Janeiro. The teacher described the facts related to the journey of the Royal Portuguese Family from Portugal to Brazil in 1808, to escape from the threat of Napoleon’s inbreak. She used a map of the Western World as a support to locate some countries involved in important historical events in the early nineteenth century: France, England, Germany, Italy, Russia, Portugal and Brazil. The children, characterized as students who lived in the slums built on the hills of Rio de Janeiro, asked questions about information not given by the teacher, but objects of interest to boys and girls familiar with the slum environment in Rio: modern weapons handling, war, violence and death. Some students expressed that the subject of the lesson was not clear for them (one of them thought that there was a participation of the Ancient Romans in the episode), and some had problems about the meaning of some words, such as the polysemous Portuguese word “coroa” (in English “crown”), but their doubts and questions were not solved by the teacher.
Do Political Institutions Influence International Trade? Measurement of Institutions and the Long-Run Effects

The past literature presents ambiguous evidence about the bidirectional and causal influences between countries’ institutional framework and their trading activity. In our analysis, we investigate the relationship between institutions and trade constructing a measure of institutions from the information given by the International Country Risk Guide and using a methodology that can control for omitted variables bias, endogeneity in the regressors, as well as cross-country heterogeneity. We examine the long-run effects of the political institutional framework on trade for a panel of 87 countries for the period from 1990 to 2007. We employ recent panel econometric methods for testing and estimating in the presence of non-stationarity, investigate panel causality and use methods that are robust to slope heterogeneity. Our results imply that an improved political institutional framework is a cause of increased trading activity.
Schorfheide “ Macroeconomic Dynamics Near the ZLB : A Tale of Two Countries ” PIER Working Paper 14-035

We propose and solve a small-scale New-Keynesian model with Markov sunspot shocks that move the economy between a targeted-inflation regime and a deflation regime and fit it to data from the U.S. and Japan. For the U.S. we find that adverse demand shocks have moved the economy to the zero lower bound (ZLB) in 2009 and an expansive monetary policy has kept it there subsequently. In contrast, Japan has experienced a switch to the deflation regime in 1999 and remained there since then, except for a short period. The two scenarios have drastically different implications for macroeconomic policies. Fiscal multipliers are about 20% smaller in the deflationary regime, despite the economy remaining at the ZLB. While a commitment by the central bank to keep rates near the ZLB doubles the fiscal multipliers in the targeted-inflation regime (U.S.), it has no effect in the deflation regime (Japan). JEL CLASSIFICATION: C5, E4, E5