Miracle-dz/UniFAR-FTUs huggingface dataset:
Translational Control of p27Kip1 Accumulation During the Cell Cycle

Cell cycle phase transitions in eukaryotic cells are driven by regulation of the activity of protein kinases known as cyclin-dependent kinases (Cdks). A broad spectrum Cdk-inhibitory activity associated with a 28-kilodalton protein (p28Ick1) was induced in cells treated with the drug lovastatin or upon density-mediated growth arrest and was periodic in the cell cycle, with peak activity in G1. The p28Ick1 protein was shown to be identical to p27Kip1, and the periodic or induced inhibitory activity resulted from a periodic accumulation of the protein. Variations in the amount of p27 protein occurred, whereas the abundance of the p27 messenger RNA remained unchanged. In every instance investigated, the posttranscriptional alteration of p27 protein levels was achieved in part by a mechanism of translational control, although in density-arrested fibroblasts and thymidine-arrested HeLa cells the half-life of the protein was also changed.
Ectopic Pregnancy: A Devastating Catastrophe

Ectopic pregnancy is the most devastating catastrophe in early pregnancy. The clinical presentation of ectopic pregnancy has changed from a life-threatening disease, necessitating emergency surgery, to a benign condition in frequently asymptomatic women for whom non-surgical treatment options are available. The purpose was to study the profile of the patients with ectopic pregnancy. The present study was conducted in the Department of Obstetrics and Gynaecology, Zenana Hospital, SMS Medical College, Jaipur during a period of 1 year from January 2013 to December 2013. 70 cases of ectopic pregnancy were analyzed in terms of demographic profile, clinical presentation, management, morbidity, mortality and risk factors for ectopic pregnancy. Most common age and parity affected by ectopic pregnancy were 20-25 yrs (68.57%) and para 1 (45.71%) respectively. No age and parity were immune to ectopic pregnancy. More than one clinical feature was present in most of the patients. Most common site of ectopic pregnancy was ampullary region of the tube. Salpingectomy was the most common surgical procedure performed (82.86%). Few patients had more than one complication. 35 cases had no complication. No maternal mortality occurred during this period. Around 85.71% women (n = 60) received blood transfusion. It is a disastrous condition and early diagnosis and prompt conservative surgical or medical treatment is required in reducing maternal morbidity and mortality but also go a long way in preservation of future fertility. Hence, if any sexually active women presents with acute abdomen with anaemia, one should always consider the possibility of ectopic pregnancy in mind.
Extra costs of integrity: Pharmacy markups and generic substitution in Finland

I evaluate how the probability of substitution of a prescribed drug in a pharmacy depends on the pharmacists' profits and patients' out of pocket costs. I use Finnish population-wide data covering all prescriptions of three popular antidepressants. I find that one euro increase in the total markup difference between the prescribed drug and its cheapest available substitute is associated with 1.7 percentage points decrease in the probability of substitution. This result is driven by brand-name drugs. An increase in the patients' out of pocket cost differential yields a 0.6 percentage points increase in the probability of accepting the substitution. My findings offer novel evidence that pharmacists' incentives are instrumental for prescription drug cost savings and overall cost effectiveness of the health care system.
An Adaptation of the Motivated Strategies for Learning Questionnaire (MSLQ) for Postgraduate Students in Pakistan: Results of an Exploratory Factor Analysis.

This paper presents the results of an exploratory factor analysis of the motivation scales of Motivated Strategies for Learning Questionnaire (MSLQ). This analysis was a part of my PhD research on motivational beliefs, course experiences and future plans of the postgraduate students in Pakistan. An exploratory factor analysis of motivational subscales was used to examine the factor structure and internal reliability of these scales with a sample of 368 postgraduate students in the context of Pakistan. The results of the study showed that the factor structure of the six motivation scales of the MSLQ was significantly modified with the current sample of postgraduate students in Pakistan. These results indicated that there was a need for further development and careful adaptation of MSLQ for use in other eastern contexts in general and in the context of Pakistani higher education in particular.
Correlation of Hemoglobin Level and Body Mass Index in Otherwise Healthy Young Adults

Nutritional anaemia is prevalent in the developing country like India especially among women. Adolescence is considered as a nutritionally critical period of life which is more susceptible for developing anaemia. To determine the association between haemoglobin (Hb) concentration and body mass index (BMI). Two hundred and fifty otherwise healthy young medical students of both sexes were taken as sample. Height was measured by portable stadiometer to nearest 0.1cm and weight was measured by digital weighing scale with 0.1kg sensitivity. Haemoglobin was estimated in gm% by Sahli’s acid haematin method. Data was presented in mean and standard deviation. Unpaired t-test and Pearson correlation was carried out in Microsoft Excel. Thirty-two percent girls and no boys found anaemic. There was no correlation between Hb concentration and BMI in both male and female student. Anaemia is also prevalent in literate medical students who are aware about health and disease. BMI showed insignificant correlation with haemoglobin level.
Highly selective multi-target 3D-printed microfluidic-based breath analyzer

This paper presents a low-cost, portable, and highly selective 3D-printed gas sensor for detection of human breath biomarker gases. To show the diagnostic power of the developed miniaturized gas sensor, capable of differentiating (ppm level) small concentrations of different volatile organic compounds (VOCs), the binary and triple mixtures of biomarkers in breath are tested. The main advantage of the proposed device over previous microfluidic-based gas sensors is the enhanced selectivity of gas detection in complex mixtures (using a novel surface treatment and optimization of the microchannels geometry). Moreover, the sensor recovery time is reduced to 120 seconds, as opposed to over 15 minutes in previous studies (without the coating).
The impact of cash transfers on women and girls A summary of the evidence

This briefing summarises the findings on the impacts of cash transfers on women and girls. These are drawn from a rigorous review of the evidence looking at the impacts of cash transfers across six outcome areas (Bastagli et al., 2016). The review covered literature spanning 15 years (2000–2015). It is distinct from other cash transfer reviews in terms of the methods used, the breadth of the evidence synthesised, and the focus on programme design and implementation features.
Effects of moisture content on some physical and mechanical properties of three varieties of cowpea ( v igna unguiculata ( L ) walp )

The effects of moisture content on the physical, mechanical and frictional properties of three varieties of cowpea, Ife Brown, IT86D-1010 and IAR-339-1 were investigated at four different moisture content levels (15%, 20%, 25% and 30% dry basis). These properties are important in the design of appropriate machines for harvesting, processing, transporting, separating, packaging and storage processes. The axial dimension, mean diameter, sphericity, surface area, porosity, true and bulk density, angle of repose, coefficient of friction of the three varieties of cowpea were determined by using a standard method. The results obtained from the study revealed that length, width, thickness, arithmetic and geometric diameter, sphericity, surface area and 1000 unit mass ranged from 9.87-15.21 mm, 7.00-10.88 mm, 5.49-8.47 mm, 7.45-11.52 mm, 7.24-11.19 mm, 0.67-0.79, 164.70-393.43 mm, 253.80-671.4 g accordingly. The mean porosity, true and bulk densities, hardness and angle of repose were investigated for the three varieties. The obtained results ranged from 31.4-38.6, 1 010.83-979.59 kg/m, 1 054.88-1 014.54 kg/m and 1 083.12-1 037.53 kg/m, 703.49-636.41 kg/m, 689.29-622.12 kg/m and 726.91-672.05 kg/m and 24.3-29.7. The static coefficient of friction was determined for two structural surfaces namely, glass and plywood. The plywood as structural surface had higher coefficient of static friction for all the three varieties of cowpea investigated. Data obtained were subjected to analysis of variance (ANOVA), Duncan Multiple Range (DMR), linear regression analysis and descriptive statistics using Statistical Analysis System. All the engineering properties of the three varieties of cowpea studied were significantly different (P<0.05).
Antiproliferative and cytotoxicity effects of grape products and resveratrol in human cancer cell lines

Red grape products have been known to be antioxidants and anticarcinogenic properties. The present study investigated the total phenolic compound (TPC) contents of Zinfandel grape products, wine, juice and pomace, from the Suranaree University of Technology farm. The effects of grape products and trans-resveratrol on cytotoxicity and apoptotic induction on human cancer cell lines were investigated. The TPC content of ethanolic grape pomace extract (4,407.33±13.65 mg/L) was significantly higher than those of red wine (3,613.00±15.13 mg/L) and grape juice (1,102.67±21.96 mg/L). Trans-resveratrol and ethanolic grape pomace extract exhibited cytotoxic effects on pancreatic cancer : Panc 2.03 cells and cholangiocarcinoma : SNU 1079 cells in a dose dependent manner assessed by MTS assay. The cytotoxic activity was mediated via apoptosis. These data suggest a possible mechanism of cytotoxicity in both cancer cell lines, at least in part, through the regulation of apoptosisrelated proteins.
Sensory Integration in the Learning of Aiming toward “Self-Defined” Targets

Abstract This study aimed at supporting the specificity of learning hypothesis, when aiming was based on internal cues, as directing the hand toward a “self-defined” target location. Participants practiced modest (20 trials) or intensive (720 trials) training with visual and proprioceptive information or proprioceptive information only. Pretests and posttests were performed in sensory conditions that did or did not match the training condition. Results showed that dynamic visual cues played a dominant role at the beginning of the task, and an intensive practice resulted in increased accuracy of kinesthetic information and efferent mechanisms of motor responses. These results have implications with regard to motor learning conceptions and training as a function of the task constraints.
Forward Looking Analysis Approach to Assess Copper Acetate Thermal Decomposition Reaction Mechanism

Thermal decomposition course of copper acetate monohydrate was monitored by combining diffuse reflectance infrared Fourier transform spectroscopy (DRIFT) coupled with μ gas chromatography-mass spectrometry (μGC-MS) with other analytical techniques (thermogravimetry analysis and in situ X-ray diffraction). Non-isothermal kinetic was examined in air and Ar. A complete analysis of the evolution of infrared spectra matched with crystalline phase transition data during the course of reaction allows access to significant and accurate information about molecular dynamics. While thermogravimetry gives broad conclusion about two steps reaction (dehydration and decarboxylation), in line approach (in situ X-ray and in situ DRIFT coupled to μGC-MS) is proposed as an example of a new robust and forward-looking analysis. While decomposition mechanism of copper acetate monohydrate is still not well elucidated yet previously, the present in-line characterization results lead to accurate data making the corresponding mechanism explicit.
The Agreement Theta Generalization

In this paper, we propose a new generalization concerning the structural relationship between a head that agrees with a DP in 𝜑 -features and the predicate that assigns the (ﬁrst) thematic role to that DP: the Agreement Theta Generalization (ATG). According to the ATG, conﬁgurations where the thematic-role assigner is located in a higher clause than the agreeing head are categorically excluded. We present empirical evidence for the ATG, discuss its analytical import, and show that this generalization bears directly on the proper modeling of syntactic agreement, as well as the prospects for reducing other syntactic (and syntacto-semantic) dependencies to the same underlying mechanism
Title On two simple and effective procedures for high dimensionalclassification of general populations

In this paper, we generalize two criteria, the determinant-based and trace-based criteria proposed by Saranadasa (1993), to general populations for high dimensional classification. These two criteria compare some distances between a new observation and several different known groups. The determinant-based criterion performs well for correlated variables by integrating the covariance structure and is competitive to many other existing rules. The criterion however requires the measurement dimension be smaller than the sample size. The trace-based criterion in contrast, is an independence rule and effective in the “large dimension-small sample size” scenario. An appealing property of these two criteria is that their implementation is straightforward and there is no need for preliminary variable selection or use of turning parameters. Their asymptotic misclassification probabilities are derived using the theory of large dimensional random matrices. Their competitive performances are illustrated by intensive Monte Carlo experiments and a real data analysis.
Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model.

The modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione (TTAD) were investigated in a rat wide-spectrum organ carcinogenesis model. Animals were initiated with two i.p. injections of 1000 mg/kg body wt 2,2'-dihydroxy-di-n-propylnitrosamine (DHPN) followed by two i.g. administrations of 1500 mg/kg body wt N-ethyl-N-hydroxy-ethylnitrosamine (EHEN), and then three s.c. injections of 75 mg/kg body wt 3,2'-dimethyl-4-aminobiphenyl (DMAB) during the first 3 weeks. Starting 1 week after the last injection, groups of rats received diet containing 1% gamma-oryzanol, 2% phytic acid, 0.2% TTAD or 1% tannic acid or basal diet alone for 32 weeks. Animals were then killed and complete autopsy was performed at the end of week 36. Histological examination revealed enhancement of lung carcinogenesis by gamma-oryzanol, and the incidence of urinary bladder papillomas to be increased by phytic acid. On the other hand, TTAD inhibited hepatic and pancreatic carcinogenesis. Phytic acid and tannic acid were marginally effective in inhibiting hepatic and colon carcinogenesis respectively. The results thus indicated that naturally occurring antioxidants each exert specific modifying effects depending on the organ site and indicate that wide-spectrum carcinogenesis models are useful for defining complex influences.
Assessing pre-service history teachers' pedagogical content knowledge with a video survey using open-ended writing assignments and standardized rating items

This paper explores pre-service history teachers' ability to recognize and reflect on typical situations occurring in the history classroom and to link these to students' historical learning. Therefore, we draw on the concept of professional vision (Goodwin, 1994), which assumes that teachers need a professional knowledge base to monitor and to reason about teaching and student learning. Based on theoretical notions of teachers' pedagogical content knowledge (PCK), we investigated history teachers' professional vision by means of a video survey with integrated video clips, open-ended writing assignments and standardized item ratings. We collected data from 303 and 220 pre-service teachers at the beginning and at the end, respectively, of their subject-specific teacher training. The collected data open up the possibility of 'simultaneous triangulation' (Morse, 1991), which was used for test validation. First, we tested the reliability of the closed-ended test instrument using item response theory, in order to develop a feasible test model. Second, we investigated the validity of the test instrument by comparing test results with the findings of the open-ended writing task. In general, student teachers reached rather low test scores. They experienced difficulties in assessing classroom events in terms of their potential to support historical competencies and to evaluate the consequences for students' learning. Findings from the open writing assignment show that student teachers commented largely on generic teaching strategies while hardly noticing student learning. In sum, the chosen methodological approaches seem to contribute to a more distinct picture of preservice teachers' abilities to reason about history teaching and learning.
Perforation of polycarbonate sheet when subjected to impact test– A review

Polycarbonate (PC) material has a variety of applications which offers high resistance to impact loadings. Perforation performance of a projectile striking a PC target is the main character that determines the resistance capability of PC mate-rial. There are three methods to investigate the PC penetration trajectories such as experimental test, numerical modeling and combination of experimental and simulation values. The ob-jective of this review paper is to discuss all the available re-search methods on the penetration of PC material, and record their potential and lack areas. Moreover investigations of mul-tilayered plates with different materials bonded together with PC plates to observe the impact effects of different projectiles shapes are been discussed. Furthermore the analysis of PC material behaviors during different stress-strain rates are also been presented in this paper.
How Do Indian Substance Users Perceive Stigma Towards Substance Use Vis-A-Vis Their Family Members?

Perceived stigma towards substance use may determine family members’ willingness to help in the treatment process of a substance user. This study aimed to compare the perceived stigma towards substance use among Indian substance users and their family members. Fifty dyads each of alcohol- and opioid-dependent men and their family members were recruited through purposive sampling. Perceived stigma was assessed using Perceived Stigma of Substance Abuse Scale (PSAS) in both the dependent men and the family members. PSAS scores of patients and the family members correlated with each other in both the alcohol- and opioid-dependent groups. Being currently employed predicted higher PSAS scores among patients, while being unmarried predicted higher PSAS scores among family members.
Social Cognitive Factors and Perceived Social Influences That Improve Adolescent eHealth Literacy

While adolescents are increasingly using the Internet for health information, little research has been done to assess and improve their “eHealth literacy”—the abilities to find, evaluate, and apply online health information. This study examines the extent to which adolescents' levels of eHealth literacy can be improved by known determinants such as social cognitive factors and perceived social influences, either independently or jointly. Among 182 middle-schoolers, an eHealth literacy intervention was carried out. It involved qualitative and quantitative baseline research, three online training sessions, and a postintervention survey. According to hierarchical regression model results, social cognitive factors of outcome expectations and involvement, but not health motivation, significantly improved eHealth literacy, and all the perceived social influence variables significantly improved eHealth literacy. However, no joint effect of social cognitive factors and perceived social influences was found. In light of these findings, educators need to make eHealth literacy programs personally relevant to adolescents and reinforce local social norms about the importance of seeking health information online.
Clustering of behavior-related risk factors and its association with subjective health.

OBJECTIVES To describe the clustering of behavior-related risk factors in the adult population of the Autonomous Community of Madrid (Spain) and evaluate the association between the level of aggregation of these factors and suboptimal subjective health. METHODS Data were drawn from the Non-communicable Disease Risk-Factor Surveillance System (Sistema de Vigilancia de Factores de Riesgo asociados a Enfermedades No Transmisibles [SIVFRENT]). We studied the associations between smoking, high-risk alcohol consumption, leisure-time sedentariness and unbalanced diet in 16,043 persons aged 18-64 years and compared the observed against the expected proportions. Logistic regression was used to estimate the association between clustering of risk factors and suboptimal health (fair, poor and very poor). RESULTS Almost 20% of subjects had 3 or 4 risk factors simultaneously. Most combinations of 3 risk factors exceeded expectations and, in particular, 4 factor clustering yielded observed/expected quotients of 2.15 (95% confidence interval [CI]: 1.93-2.38) in men and 2.96 (95% CI, 2.46-3.46) in women. In both sexes, the individual factor most closely associated with the remaining risk factors was smoking. Aggregation of risk factors was more frequent among men, younger age groups and subjects with low educational level. Compared with persons with none of the 4 risk factors, those that simultaneously had 3 or 4 more frequently reported suboptimal subjective health (OR = 2.49; 95% CI, 1.59-3.90 in men and OR = 1.96; 95% CI, 1.29-2.97 in women). CONCLUSIONS Behavior-related risk factors tend to aggregate, and this accumulation is higher among men, younger age groups, and subjects with a low educational level. A greater level of clustering is associated with a higher frequency of suboptimal perceived health.
Farm economic sustainability in the European Union: A pilot study

The measurement of farm economic sustainability has received intermittent academic interest in recent times, while the conceptual discussions are often quite limited. Moreover, this concept receives more attention at periods of diffi culty for the sector. The measurement of farm viability is an important precondition to enrich these discussions. Therefore, it is necessary to develop more comprehensive and detailed measurement techniques to provide more clarity on viability and vulnerability levels in the sector. This paper refocuses attention on this issue, using a pilot dataset collected at farm level across a range of EU Member States which facilitates the assessment of an additional category of viability, namely that of economically sustainable farms, i.e. farms that are economically vulnerable but which are deemed sustainable by the presence of off-farm income. Differences in viability and economic sustainability across the eight surveyed Member States are shown. The analysis is sensitive to the factors included in the measurement of viability as well as to the threshold income used to defi ne viability. Although this is a pilot study, it enhances our understanding of the factors affecting cross-country evaluation of viability and sustainability, and the policy instruments that could improve viability levels.