Miracle-dz/UniFAR-FTUs huggingface dataset:
Successful treatment of human Waldenström's macroglobulinemia with combination biological and chemotherapy agents.

The immunomodulating effects and antitumor activity of two biological agents, bryostatin 1 (Bryo1) and alpha-interferon, were tested in vitro and in vivo either alone or prior to chemotherapy agents, against a Waldenström's macroglobulinemia tumor line (WSU-WM). Bryol caused a decrease in the expression of CD10, CD19, IgM, Leu10, and CD22 and a temporary growth inhibition as measured by cell cycle analysis. alpha-Interferon did not show any major effects. In vivo, severe combined immunodeficient mice were used to test the activity of the agents against WSU-WM. Bryo1 (i.p.) was given either alone or sequentially with doxorubicin (i.v.), vincristine (i.v.), melphalan (i.v.), and alpha-interferon (i.v.). Bryo1 given 24 h before vincristine or melphalan resulted in the highest tumor growth inhibition, tumor growth delay, and tumor cell kill. Two of five mice receiving Bryo1/vincristine combination were free of tumors > 200 days after treatment and were considered cured. In light of our findings, we recommend that Bryo1 be considered for clinical investigation in human B-cell tumors and might best be given combined with other chemotherapy agents used in the treatment of that disease. Whether Bryo1 is acting as a differentiating agent or as a direct anti-Waldenström's macroglobulinemia tumor agent, remains unclear.
Evaluation of microRNA alignment techniques

Genomic alignment of small RNA (smRNA) sequences such as microRNAs poses considerable challenges due to their short length (∼21 nucleotides [nt]) as well as the large size and complexity of plant and animal genomes. While several tools have been developed for high-throughput mapping of longer mRNA-seq reads (>30 nt), there are few that are specifically designed for mapping of smRNA reads including microRNAs. The accuracy of these mappers has not been systematically determined in the case of smRNA-seq. In addition, it is unknown whether these aligners accurately map smRNA reads containing sequence errors and polymorphisms. By using simulated read sets, we determine the alignment sensitivity and accuracy of 16 short-read mappers and quantify their robustness to mismatches, indels, and nontemplated nucleotide additions. These were explored in the context of a plant genome (Oryza sativa, ∼500 Mbp) and a mammalian genome (Homo sapiens, ∼3.1 Gbp). Analysis of simulated and real smRNA-seq data demonstrates that mapper selection impacts differential expression results and interpretation. These results will inform on best practice for smRNA mapping and enable more accurate smRNA detection and quantification of expression and RNA editing.
CORPORATE SOCIAL ENVIRONMENTAL RESPONSIBILITYEXPENDITURE, FOREIGN INVESTMENT AND CORPORATEFINANCIAL PERFORMANCE

The accounting system of corporate social and environmental responsibility (CSER) costs is still unable to disclose and accumulate the true value of CSER activities. The costs of CSER is known as CSER expenditure. The CSER expenditure consists of three elements namely expenditure of environmental management, expenditure of social contribution, and expenditure of research and development of production. The purpose of this study is to examine the relationship between the elements of CSER expenditure on foreign investment activities and its impact on corporate financial performance. Sample of this study consists of 132 manufacturing companies for period of 2012-2016, The results of this study show that the elements of CSER expenditure have significant influence on foreign investment and corporate financial performance.
Treatment of eight dogs with nasal tumours with alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam.

OBJECTIVE To determine the efficacy and toxicity of chemotherapy in the treatment of canine nasal tumours. DESIGN Retrospective clinical study PROCEDURE Eight dogs with histologically confirmed nasal tumours were staged by means of complete blood count, serum biochemical analysis, cytological analysis of fine needle aspirate of the regional lymph nodes, thoracic radiographs and computed tomography scan of the nasal cavity. All dogs were treated with alternating doses of doxorubicin, carboplatin and oral piroxicam. All dogs were monitored for side effects of chemotherapy and evaluated for response to treatment by computed tomography scan of the nasal cavity after the first four treatments. RESULTS Complete remission was achieved in four dogs, partial remission occurred in two dogs and two had stable disease on the basis of computed tomography evaluation. There was resolution of clinical signs after one to two doses of chemotherapy in all dogs. CONCLUSIONS This chemotherapy protocol was efficacious and well tolerated in this series of eight cases of canine nasal tumours.
Drivers and barriers of entrepreneurial intentions in times of economic crisis: The gender dimension

This paper shows results of a study on entrepreneurial intentions in Greece in times of a major and prolonged economic crisis, with a focus on the dimension of gender. The paper provides insights about drivers and barriers that affect intentions of becoming an entrepreneur. Results show relatively low intention of starting a business, whereas personal attitudes toward becoming an entrepreneur and perceived desirability are high. Furthermore, economic barriers, public policy barriers and business risk barriers towards undertaking entrepreneurial activities are considered to be highly important as compared to personal barriers. As far as gender is concerned, results show that, generally speaking, male and female potential entrepreneurs are quite similar in their motivation towards entrepreneurship during turbulent times.
Corporate Social Responsibility Effect on Information Asymmetry

This study was aimed to answer the question of whether Corporate Social Responsibility (CSR) disclosure as one form of voluntary disclosure can reduce the asymmetric information in Indonesian capital market, as a developing country. In other words, whether information about the performance of CSR provides benefits to investors by reducing uncertainty. The 267 samples used were all companies listed on the Indonesia Stock Exchange from 2014 to 2015, except for the financial and banking industries. Asymmetry information would be measured with bid-ask spreads, the larger the spread, the higher the asymmetry information. CSR disclosure would be measured by content analysis, using the index of previous research that has been adjusted to the conditions in Indonesia, then the sample will be separated based on the mining industry, manufacturing, and services. The results of this study showed that the disclosure of corporate social responsibility could reduce information asymmetry. Companies in the manufacturing industry were more sensitive to social and environmental issues (covered by CSR activities) so that CSR information on this industry was more relevant to investors than to the service industry.
A New Information System for Inventory Management in Hospitality Industry

Design/methodology/approach – This study adopts case study on a sample of five-star hotel chains. The study adopted the typical sampling. Data collection tools of the study are observation, interviews and document analysis (procedures and forms). The ARIMA (2,1,1) Model was utilized as the estimator in this study. The software is web-based, and uses SQL 2008 R2 as database management system. Coding was performed in C #.
PENGARUH INTELLECTUAL CAPITAL TERHADAP KINERJA KEUANGAN DAN NILAI PERUSAHAAN (Studi pada Perusahaan Sektor Manufaktur yang terdaftar di Bursa Efek Indonesia Periode 2012-2017)

This research is conducted considering that intellectual capital is an important resource used to create value added for companies in the era of knowledge based business. This research is conducted on Manufacturing companies listed on Indonesian Stock Exchange periode 2012-2017 because manufacturing sector companies have the highest investment rates compared to other industrial sectors. The purpose of this study is to determine the effect of intellectual capital on firm’s value, to know the effect of intellectual capital on financial performance, and to know the effect of financial performnace on firm’s value. The type of this research is explanatory research with quantitative approach, using Partial Least Square (PLS) method with Smart PLS 3.0 application.The result of this studyshows that there is a positive significant influence between intellectual capital to firm’s value. It means that, the higher intellectual capital, the higher firm’s value, vice versa. Furthemore, the study shows that intellectual capital has no significant effect on financial performance and financial performance has no effect on firm’s value.This research indicates that the manufacturing sector companies value periodes 2012-2017 is influence by intellectual capital. Kеywords: Intellectual Capital, Financial Performance, and Firm’s Value. АBSTRАK Penelitian ini dilakukan mengingat intellectual capital merupakan sumber daya yang penting digunakan untuk menciptakan nilai tambah bagi perusahaan pada era knowledge based business. Penelitian ini dilakukan pada perusahaan sektor manufaktur yang terdaftar di Bursa Efek Indonesia periode 2012-2017, karena perusahaan sektor manufaktur memiliki tingkat investasi tertinggi dari pada sektor industri lainnya.Tujuan penelitian ini adalah untuk mengetahui pengaruh intellectual capital terhadap nilai perusahaan, mengetahui pengaruh intellectual capital terhadap kinerja keuangan , dan pengaruh kinerja keuangan terhadap nilai perusahaan. Jenis penelitian ini adalah penelitian eksplanatori dengan pendekatan kuantitatif, menggunakan Partial Least Square (PLS) dengan aplikasi SmartPLS 3.0. Hasil penelitian ini menunjukkan bahwa terdapat pengaruh signifikan positif dari intellectual capital terhadap nilai perusahaan. Hal ini menunjukkan bahwa semakin tinggi intellectual capital maka semakin tinggi nilai perusahaan, begitu pula sebaliknya . Selanjutnya, hasil penelitian ini menunjukkan bahwa tidak terdapat pengaruh yang signifikan dari intellectual capital terhadap kinerja keuagan, serta tidak terdapat pengaruh yang signifikan dari kinerja keuangan terhadap nilai perusahaan. Hal ini menunjukkan bahwa nilai perusahaan pada sektor manufaktur yang terdaftar pada Bursa Efek Indonesia selama periode 2012-2017 dipengaruhi oleh intellectual capital. Kаtа Kunci: Intellectual Capital, Kinerja Keuangan, dan Nilai Perusahaan.
Narrative assessment of attachment representations: Links between secure base scripts and adolescent attachment

Abstract We explored the notion that adolescents possess mental secure base scripts of attachment-related events and examined, for the first time, whether these scripts were linked to adolescent attachment security. Results indicated that adolescents possessed a general script for mother and for father, and that they drew upon these scripts across different contexts. Adolescents' scripts for mother and for father were related, but only the scripts for mother predicted unique variance in adolescents' scripts for nonspecific others. Moreover, greater attachment security (as measured by the Adult Attachment Interview; AAI) was linked to greater access to and knowledge of secure base scripts for mothers, fathers, and nonspecific others. Only mother scripts, however, predicted unique variance in adolescents' AAI coherence of mind scores. Adolescents' romantic-attachment avoidance and anxiety scores (as assessed using the Experiences in Close Relationship Inventory) were linked negatively to scripts for mothers and nonspecific others, respectively.
Chromosomal instability detected by interphase fluorescence in situ hybridization and its relation to p53 alteration in prostate carcinoma in Saudi patients.

OBJECTIVE Chromosomal instability (CIN) is a feature of human neoplasm. The p53 mutation has been shown to be associated with CIN in many human dysplastic and neoplastic lesions. The objective of this study was to examine CIN and p53 mutations in prostate carcinoma (Pca) resected from Saudi patients. METHODS Testing of p53 alteration using immunohistochemistry was performed on 28 archived prostatic carcinoma specimens containing Pca foci from Saudi patients seen at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Chromosomal instability was evaluated in the same tissues by interphase in situ hybridization (IFISH) using centromere probes for chromosome 7 and 8. Immunohistochemistry and IFISH were performed at Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada in 2001. RESULTS The p53 immunoreactivity was found in 29% in Pca and 0% in benign epithelium. Interphase in situ hybridization revealed numerical chromosomal alterations in keeping with CIN in 63% of p53 positive and 20% p53 negative Pca. No evidence of CIN was seen in non-neoplastic epithelium. CONCLUSION We concluded that CIN as determined by IFISH is present in Pca from Saudi patients similarly to those reported in western countries. The p53 mutation occurs relatively infrequently in Pca and is associated with the presence of CIN at least in a subset of Pca.
Leverage Capability in Controlling Free Cash Flow to Improve Financial Performance

Free Cash Flow, in general, being a problem for the company if it is not good in controlling. The manager can use free cash flow for actions that can harm the company. Leverage is a cost that can control the usage of free cash flow for the company's activity, which in turn can improve financial performance. The purpose of this study is to examine the role of leverage in mediating the relationship between free cash flow and financial performance. The research variable consists of Free Cash Flow as the independent variable, the Leverage as the mediator and Financial Performance as the dependent variable. The population of this research is manufacturing companies listed on the Indonesia Stock Exchange periods 2011-2015. The sampling method is purposive sampling with criteria, and the samples that meet the criterion are 70 manufacturing companies. The research model is used Warp PLS 3.0. The results show that free cash flow has an effect on financial performance, and Leverage mediates the relationships between free cash flow and financial performance. This research contribute a novelty of science in the field of management accounting, and has positive implications for companies in determining control strategies of free cash flow through the leverage could improve the financial performance. Keywords— Leverage, Free Cash Flow, Financial Performance
PURE ENDOTOXIN DOES NOT PASS ACROSS THE INTESTINAL EPITHELIUM IN VITRO

ABSTRACT Numerous reports suggest that endotoxin (LPS) may play a central role in triggering the inflammatory cascade that leads to the systemic inflammatory response syndrome. Although conditions that promote bacterial translocation in vivo may also facilitate direct translocation of LPS, the exact mechanisms by which LPS crosses the intestinal barrier to reach the systemic circulation are unknown. This study was designed to determine whether pure endotoxin could pass across injured rat ileal mucosa in the Ussing chamber. Sprague-Dawley rats were subjected to mild or severe hemorrhagic shock following carotid artery cannulation, and then resuscitated. Control animals underwent carotid artery cannulation only (sham-shock). Bacterial translocation to the mesenteric lymph nodes, liver, or spleen was measured after 24 h. Transmucosal passage of fluorescein isothiocyanate (FITC)-labeled E. coli C-25, or FITC-conjugated LPS was measured in the Ussing chamber. Intestinal membranes were examined by light and confocal laser microscopy. Severe hemorrhagic shock resulted in a 60% mortality rate and a 100% incidence of bacterial translocation in surviving animals. Sham-shock rats had a 100% survival rate and a 33% incidence of bacterial translocation. Transmucosal passage of FITC-E. coli C-25 was similar in both groups; however, passage of FITC-LPS was never detected. Histologic analysis confirmed mucosal injury to the intestinal epithelium of rats subjected to severe hemorrhagic shock, and confocal laser microscopy demonstrated passage of FITC-E. coli C-25, but not of FITC-LPS across the ileal membranes. Disruption of the intestinal epithelium with a potent mucolytic agent did not result in significant increase in transmucosal passage of FITC-LPS. We conclude that pure LPS does not pass across the intestinal mucosa in vitro. Transmucosal passage of LPS in vivo may be due, at least in part, to the release of bacterial cell wall fragments containing LPS from killed bacteria that had previously translocated.
Mutant small heat shock protein B3 causes motor neuropathy

Objective: Idiopathic peripheral neuropathy is common and likely due to genetic factors that are not detectable using standard linkage analysis. We initiated a candidate gene approach to study the genetic influence of the small heat shock protein (sHSP) gene family on an axonal motor and motor/sensory neuropathy patient population. Methods: The promoter region and all exonic and intronic sequences of the 10 sHSP genes (HSPB1-HSPB10) were screened in a cohort of presumed nonacquired, axonal motor and motor/sensory neuropathy patients seen at the Ohio State University Neuromuscular Clinic. Results: A missense mutation in the gene encoding small heat shock protein B3 (HSPB3, also called HSP27, protein 3) was discovered in 2 siblings with an asymmetric axonal motor neuropathy. Electrophysiologic studies revealed an axonal, predominantly motor, length-dependent neuropathy. The mutation, HSPB3(R7S), is located in the N-terminal domain and involves the loss of a conserved arginine. Conclusions: The discovery of an HSPB3 mutation associated with an axonal motor neuropathy using a candidate gene approach supports the notion that the small heat shock protein gene family coordinately plays an important role in motor neuron viability.
Accuracy of Intraoperative Frozen-Section Diagnosis in Stage I Endometrial Adenocarcinoma

The purpose of our study was to determine if frozen-section diagnosis accurately identified patients suffering from endometrial adenocarcinoma FIGO stage I for surgical staging consisting of total abdominal hysterectomy, bilateral salpingo-oophorectomy, peritoneal cytology, and complete bilateral pelvic lymphadenectomy in moderately differentiated tumors with myometrial invasion. In all poorly differentiated tumors, and in all tumors with deep myometrial invasion (more than 50%) surgical staging included additional para-aortic lymphadenectomy. We performed a retrospective study including 70 patients. Frozen-section diagnosis of myometrial invasion and tumor grade was compared with permanent-section diagnosis. The accuracy rates were determined, and compared with accuracy rates of frozen-section diagnosis in the literature, and a total accuracy rate for 624 patients suffering from stage I endometrial adenocarcinoma was evaluated. In our patient collective, the overall accuracy rate of frozen-section diagnosis for myometrial invasion and tumor grade was 80 and 84%, respectively. In the five comparable studies, the mean accuracy rate for myometrial invasion and tumor grade was 89 and 84%, respectively. In combination with the five comparable studies our recent study produced an accuracy rate of frozen-section diagnosis for myometrial invasion and tumor grade of 88 and 84% in 624 patients, respectively. Despite an accuracy level of frozen-section diagnosis for myometrial invasion of 80 and 84% for tumor grade in our patient collective, all patients who required surgical staging were accurately identified.
Cross-Sectional Analysis of Renal Function in Black Americans With NIDDM

Our objective was to define glomerular filtration rate (GFR) and renal plasma flow (RPF) in Black Americans with non-insulin-dependent diabetes mellitus (NIDDM). This was a cross-sectional study of 71 Black NIDDM patients with diagnosed diabetes duration from 1 mo to 21 yr. Hyperglycemia was regulated and stabilized before patients were entered into the study. GFR and RPF were determined by the clearance of [l25I]iothalamate and 131I-labeled hippuran, respectively, with a constant-infusion technique and four urine collection periods. Hyperfiltration, as defined by a GFR of >140 ml · min−1 · 1.73 m−2, was found in 7 of 20 patients (35%) with newly diagnosed (<2 yr duration) NIDDM. The percentage of patients with hyperfiltration decreased with increasing duration of diagnosed diabetes. Decreasing GFR and RPF occurred with increasing duration of diagnosed diabetes. In conclusion, renal hemodynamic changes in Black Americans with NIDDM are similar to those known to occur in White populations with IDDM.
Differences in the In Vitro Susceptibility of Planktonic and Biofilm-Associated Escherichia Coli Strains to Antimicrobial Agents

Abstract The In Vitro susceptibility of seven Escherichia Coli biofilm-producing strains in their planktonic and biofilmassociated forms to amoxicillin, amoxicillin/clavulanic acid, cefotaxime, gentamicin, and ciprofloxacin was studied. Minimum inhibitory concentrations (MICs) were determined by the standard microdilution method and by the Alamar blue assay (providing the AB-MIC) at two levels of metabolic suppression and using standard and large inocula. Minimal biofilm inhibitory concentrations (AB-MBICs) on preformed biofilms on polystyrene plates were higher than the MICs and AB-MICs. Differences in magnitude depended on the antibiotic, strain, inoculum size, and the level of suppression of metabolism. Ciprofloxacin and gentamicin showed the greatest differences in the AB-MBIC as compared to AB-MIC. The possibility of antibiotic-resistant mutant selection within the biofilms was ruled out since bacteria recovered from the biofilm maintained the same MICs as before exposure to the antimicrobial agents. E. coli biofilms were much less sensitive than their planktonic counterparts.
Glycoprotein Hormone Assembly in the Endoplasmic Reticulum

All three human glycoprotein hormone heterodimers are assembled in the endoplasmic reticulum by threading the glycosylated end of α-subunit loop two (α2) beneath a disulfide “latched” strand of the β-subunit known as the “seatbelt. ” This remarkable event occurs efficiently even though the seatbelt effectively blocks the reverse process, thereby stabilizing each heterodimer. Studies described here show that assembly is facilitated by the formation, disruption, and reformation of a loop within the seatbelt that is stabilized by the most easily reduced disulfide in the free β-subunit. We refer to this disulfide as the “tensor” because it shortens the seatbelt, thereby securing the heterodimer. Formation of the tensor disulfide appears to precede and facilitate seatbelt latching in most human choriogonadotropin β-subunit molecules. Subsequent disruption of the tensor disulfide elongates the seatbelt, thereby increasing the space beneath the seatbelt and the β-subunit core. This permits the formation of hydrogen bonds between backbone atoms of the β-subunit cystine knot and the tensor loop with backbone atoms in loop α2, a process that causes the glycosylated end of loop α2tobe threaded between the seatbelt and the β-subunit core. Contacts between the tensor loop and loop α2 promote reformation of the tensor disulfide, which explains why it is more stable in the heterodimer than in the uncombined β-subunit. These findings unravel the puzzling nature of how a threading mechanism can be used in the endoplasmic reticulum to assemble glycoprotein hormones that have essential roles in vertebrate reproduction and thyroid function.