Miracle-dz/UniFAR-FTUs huggingface dataset:
Encephalitozoonosis (nosematosis) of the cornea.

has shown no abnormality. A bone marrow smear was negative. A blood examination gave the following results: haemoglobin 9 4 g. (64 per cent.), white blood count I2,200 per cm3. , polymorphs 51 per cent. , lymphocytes 20 per cent. , eosinophils 22 per cent. , mononuclears 7 per cent.
Job satisfaction and its influential factors.

BACKGROUND This study aimed at determining the job satisfaction level of the staff in Shahroud University of Medical Sciences (SUMS), northern Iran, and its influential factors. METHODS In this descriptive study, conducted in 2008, the participants were 384 workers in SUMS selected through simple random sampling procedure. The par-ticipants received a 33-item questionnaire in a Likert format (8 general items and 25 items related to job satisfaction facets). The collected data in form of frequen-cies and percentages were analyzed with SPSS software. RESULTS 53.4% of interviewees were female and more than 60% had associate or higher degrees. 42.6% had less than 10 yr and 30.9% had 20 to 30 yr of job experience, respectively. The mean of the overall satisfaction was 13.02 out of 20. Regarding the facets of job satisfaction, work, coworkers, supervisor, and pro-motion had the highest means, respectively. Pearson and Spearman correla-tion coefficients showed a significant relationship between overall satisfaction and the facets (P= 0.001). Analysis of variance also showed significant difference in overall satisfaction based on organizational units; however, no significant rela-tionship was observed between overall satisfaction and gender, degree, age, job experience and type of employment. CONCLUSION Improvement of promotion process, training and qualifying manag-ers, observing meritocracy principles in appointments, using cooperative man-agement, creating convivial and friendly atmosphere and improving work envi-ronment conditions, have brought about an increase in overall satisfaction of em-ployees in SUMS.
Treating Older Adults with Advanced Non‐Small Cell Lung Cancer: A Community Cancer Center Experience

ments in velocity and stride length (Table 1) that was not observed in individuals with dementia. Individuals with dementia exhibited significant interactions between fewer chair stands and the presence of impaired processing speed, verbal fluency, and executive function (Table 1). These interactions were not observed in the control group or the group with MCI. Verbal fluency was related to changes in balance in every group, with individuals with dementia also selectively exhibiting strong interactions between poorer balance and impaired executive function (Table 1). These data suggest that there are significant interactions between declines in multiple aspects of cognition and the development of poorer physical performance and gait impairment. Many of these interactions are selectively observed within people with and without dementia. These data are consistent with the potential for reciprocal interactions between specific cognitive domains (processing speed, executive function) and the development of motor disturbances during the progression of dementia. These data support previous studies outlining the potential for therapeutic interventions based on better physical performance and motor function potentially modulating cognitive decline. Such interventions may be particularly important not only in delaying or slowing the development of dementia, but also in modulating frailty and greater fall risk observed in people with MCI or dementia.
Lifespan ontogeny of breeding and reproductive success in Mongolian gerbils

An analysis was made of demographic data collected from a colony of Mongolian gerbils (Meriones unguiculatus). The data on births of over 3800 gerbils provide evidence on several aspects of development and fecundity. Approximately 4% more females than males survived to weaning. Mean number of pups per dam per year was estimated to be 48·3, greater reproductive success than reported previously. The shortest period of gestation resulting in viable pups was 25 days. Implantation was delayed by the presence of suckling pups. When gestation was prolonged, there was a direct relationship between the number of pups being suckled concurrently and the length of the delay. Length of gestation did not affect the size of the subsequent litter. Female gerbils gave birth as early as 72 days of age. Gerbils continued to reproduce until after 2 years of age in some cases. There were fewer pups per litter born to older females, fewer pups per litter with increasing parity, and longer intervals between litters with increasing age.
Protein Kinase A Inhibits Leukotriene Synthesis by Phosphorylation of 5-Lipoxygenase on Serine 523*

Leukotrienes (LTs) are lipid messengers generated by leukocytes that drive inflammation and modulate neighboring cell function. The synthesis of LTs from arachidonic acid is initiated by the enzyme 5-lipoxygenase (5-LO). We report for the first time that LT synthesis is inhibited by the direct action of protein kinase A (PKA) on 5-LO. The catalytic subunit of PKA directly phosphorylated 5-LO in vivo and in vitro and inhibited activity in intact cells and in vitro. Mutation of Ser-523 on human 5-LO prevented phosphorylation by PKA and restored LT synthesis. Treatment with PKA activators inhibited LTB4 synthesis in 3T3 cells expressing wild type 5-LO but not in cells expressing the S523A mutant of 5-LO. The mechanism of inhibition of LTB4 synthesis did not involve either reduced membrane association of activated 5-LO or redistribution of 5-LO from the nucleus to the cytoplasm. Instead, PKA phosphorylation of recombinant 5-LO inhibited in vitro activity, as did co-transfection of cells with 5-LO plus the catalytic subunit of PKA. Also, substitution of Ser-523 with glutamic acid, mimicking phosphorylation, resulted in the total loss of 5-LO activity. These results indicate that PKA phosphorylates 5-LO on Ser-523, which inhibits the catalytic activity of 5-LO and reduces cellular LT generation. Thus, PKA activation, as can occur in response to adenosine, prostaglandin E2, β-adrenergic agonists, and other mediators, is a means of directly reducing 5-LO activity and LT synthesis that may be important in limiting inflammation and maintaining homeostasis.
Chemokine Receptor CCR2 but Not CCR5 or CCR6 Mediates the Increase in Pulmonary Dendritic Cells during Allergic Airway Inflammation1

Increased numbers of pulmonary dendritic cells (DCs) are recruited to the lungs during allergic airway inflammation and contribute to the maintenance of the inflammatory immune response. The chemokine receptors that directly control DC accumulation into the lungs are largely unknown. To explore this issue, we generated mixed bone marrow chimeric mice containing both wild-type and knockout cells for a given chemokine receptor. After induction of allergic airway inflammation, we specifically tracked and compared chemokine receptor knockout vs wild-type DC populations through various lung compartments. Using this approach, we show that CCR2, but not CCR5 or CCR6, directly controls the accumulation of DCs into allergic lungs. Furthermore, the size of inflammatory monocyte populations in peripheral blood was strikingly CCR2 dependent, suggesting that CCR2 primarily mediates the release of monocytic DC precursors into the bloodstream.
Analyses of reproductive interactions that occur after heterospecific matings within the genus Caenorhabditis.

Formation of zygotes in internally fertilizing organisms requires a number of successful interactions between oocytes and sperm within a receptive female reproductive tract. These interactions are usually assumed to be species-specific. For most species, it is either not possible to inseminate females with sperm from a different species or not possible to observe the consequences of such an insemination because the female is opaque. Nematodes of the genus Caenorhabditis are optically transparent and prior work indicates copulation between individuals of two different species is possible. We have used a series of vital stains and other cytological methods to analyze sperm after cross-species mating. We present here a series of analyses of the postcopulatory, prefertilization interactions among three Caenorhabditis species and find that reproductive biology is conserved, to varying degrees, among all three species. This approach allows investigation into which in vivo interactions between sperm and both oocytes and the somatic gonad have been maintained during the reproductive isolation that accompanies speciation.
Modified GLRT and AMF Framework for Adaptive Detectors

The well-known general problem of signal detection in background interference is addressed for situations where a certain statistical description of the interference is unavailable, but is replaced by the observation of some secondary (training) data that contains only the interference. For the broad class of interferences that have a large separation between signal-and noise-subspace eigenvalues, we demonstrate that adaptive detectors which use a diagonally loaded sample covariance matrix or a fast maximum likelihood (FML) estimate have significantly better detection performance than the traditional generalized likelihood ratio test (GLRT) and adaptive matched filter (AMI') detection techniques, which use a maximum likelihood (ML) covariance matrix estimate. To devise a theoretical framework that can generate similarly efficient detectors, two major modifications are proposed for Kelly's traditional GLRT and AMF detection techniques. First, a two-set GLRT decision rule takes advantage of an a priori assignment of different functions to the primary and secondary data, unlike the Kelly rule that was derived without this. Second, instead of ML estimates of the missing parameters in both GLRT and AMF detectors, we adopt expected likelihood (EL) estimates that have a likelihood within the range of most probable values generated by the actual interference covariance matrix. A Gaussian model of fluctuating target signal and interference is used in this study. We demonstrate that, even under the most favorable loaded sample-matrix inversion (LSMI) conditions, the theoretically derived EL-GLRT and FL-AMF techniques (where the loading factor is chosen from the training data using the EL matching principle) gives the same detection performance as the loaded AMF technique with a proper a priori data-invariant loading factor. For the least favorable conditions, our EL-AMF method is still superior to the standard AMF detector, and may be interpreted as an intelligent (data-dependent) method for selecting the loading factor.
Ghrelin, leptin, adiponectin, and insulin levels and concurrent and future weight change in overweight, postmenopausal women

Objective:Weight loss and maintenance can be particularly challenging for postmenopausal women given the changes in body composition, metabolism, and lifestyle that can accompany the menopausal transition. Peptides mediating energy homeostasis (ghrelin, leptin, adiponectin, and insulin) may play an important role in the weight and body composition changes of postmenopausal women and may in turn be affected by hormone therapy (HT) use. This study examines how success with weight loss may be related to peptides mediating energy homeostasis and HT use. Methods:The present analysis involves 200 women from a lifestyle intervention trial in overweight, postmenopausal women for whom data on the peptides ghrelin, leptin, adiponectin, and insulin were collected at 0 and 18 months. Peptide levels were compared with changes in weight from 0 to 18 and from 18 to 30 months. Results:Baseline peptide levels were not significantly related to future weight change. From 0 to 18 months, ghrelin (P = 0.0005) and adiponectin (P ≤ 0.0001) levels increased, whereas leptin (P ≤ 0.0001) and insulin (P = 0.0003) levels decreased with increasing amount of weight loss. However, only leptin change was related to 18-30-month weight change. Women who were on HT at 0 months but discontinued by 18 months had a greater increase in ghrelin level from 0 to 18 months compared with women with continuous HT use or nonuse. Conclusions:In overweight, postmenopausal women, changes in energy homeostasis peptides relate to both concurrent and future weight change. Future studies should continue to address how ghrelin, leptin, insulin, and adiponectin contribute to body composition changes and weight loss maintenance after menopause.
Performance comparisons for adaptive LEO satellite links

This paper considers the potential to achieve improved throughput in time‐varying satellite links which have flexibility in information bit rate and/or transmit power. We assume that other parameters of the link budget such as antenna gains and operating frequency are fixed. Simple results are derived, which illustrate what improvements in data throughput or power consumption are possible under two low‐earth orbit scenarios: inter‐satellite links and satellite to ground communications. Copyright © 2006 John Wiley & Sons, Ltd.
Preoperative management of antithrombotic medication in Mohs micrographic surgery.

© 2015 The Authors. doi: 10.2340/00015555-2090 Journal Compilation © 2015 Acta Dermato-Venereologica. ISSN 0001-5555 Many patients presenting for dermatologic surgery use antithrombotic medication. It remains controversial whether or not this medication should be withheld prior to cutaneous surgery. Different studies, including one meta-analysis, have assessed the risk of bleeding when antithrombotic medication was continued and showed conflicting results (1–8). Furthermore, case reports illustrated the potential life-threatening risk of temporary discontinuation of antithrombotic medication (9–11). We evaluated the frequency of postoperative haemorrhage and thrombotic events in patients continuing their antithrombotic medication with those temporarily withholding this medication prior to Mohs micrographic surgery.
Multifocal or generalized tonic dystonia of complex regional pain syndrome: A distinct clinical entity associated with HLA‐DR13

We report on 26 patients with a distinct phenotype of complex regional pain syndrome that progressed toward a multifocal or generalized tonic dystonia. The dystonia initiated distally, involved mainly flexor muscles, and was associated with sensory and autonomic symptoms. Dryness of the eyes or mouth and bladder and bowel disturbances were frequently reported. There was no increase in the familial prevalence of autoimmune‐mediated diseases. Compared with controls, a significant elevation of HLA‐DR13 was found in the patients. Thus, HLA‐DR13 may be a factor indicating susceptibility to this distinct phenotype of complex regional pain syndrome. Ann Neurol 2000;48:113–116
2-Keto-d-Gluconate-Yielding Membrane-Bound d-Glucose Dehydrogenase from Arthrobacter globiformis C224: Purification and Characterization

Glucose dehydrogenase (GlcDH) is the rate-limiting catalyst for microbial conversion of glucose to the important organic acid 2-ketogluconic acid (2KGlcA). In this study, a d-glucose dehydrogenase was purified from the industrial 2KGlcA producer Arthrobacter globiformis C224. After four purification steps, the GlcDH was successfully purified over 180 folds and specific activity of 88.1 U/mg. A single protein band of 87 kDa was detected by SDS-PAGE. The purified GlcDH had the broad substrate specificity with the Km values for d-glucose, d-xylose, d-galactose and maltose of 0.21 mM, 0.34 mM, 0.46 mM and 0.59 mM, respectively. The kinetic studies proved that A. globiformis GlcDH followed the ping-pong kinetic mechanism. The GlcDH showed an optimum catalytic activity at pH 5.0 and 45 °C with the stable activity at temperature of 20–40 °C and pH of 6.0–7.0. Organic solvents, metal ions or EDTA could significantly influence the GlcDH activity to different degrees.
The capacitance loss mechanism of metallized film capacitor under pulsed discharge condition

The metalized capacitor has high energy storage density for its self-healing characteristic and is often used in pulsed power applications. The pulse life is defined as the number of charge/discharge cycles before 5% decrease in capacitance. In order to reduce the capacitance loss in the active electrode area (AEA), segmented electrodes are designed to decrease the clearing energy. In this electrode pattern, a large capacitance loss is observed along the segmented electrode edge (SEE). The loss along the SEE is caused by two reasons: electrode recession caused by electrochemical corrosion and self-healing induced by the combined effect of partial discharge and electric field distortion. According to teardown observation, there is an unexpected capacitance loss competition in the AEA and along the SEE under various voltages. Based on the analysis of the capacitance loss mechanism, three kinds of metalized electrode patterns are designed and tested. The result indicates that a proper electrode pattern helps to increase the pulse life of capacitor.
Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: Results of a multicenter, prospective survey*

Objective:To survey the natural history of disseminated intravascular coagulation (DIC) in patients diagnosed according to the Japanese Association for Acute Medicine (JAAM) DIC scoring system in a critical care setting. Design:Prospective, multicenter study during a 4-month period. Setting:General critical care center in a tertiary care hospital. Patients:All patients were enrolled when they were diagnosed as DIC by the JAAM DIC scoring system. Interventions:None. Measurements and Main Results:Platelet counts, prothrombin time ratio, fibrinogen, and fibrin/fibrinogen degradation products were measured, and the systemic inflammatory response syndrome criteria met by the patients were determined following admission. Of 3,864 patients, 329 (8.5%) were diagnosed with DIC and the 28-day mortality rate was 21.9%, which was significantly different from that of the non-DIC patients (11.2%) (p < .0001). The progression of systemic inflammation, deterioration of organ function, and stepwise increase in incidence of the International Society on Thrombosis and Haemostasis (ISTH) DIC and its scores all correlated with an increase in the JAAM DIC score as demonstrated by the patients on day 0. There were significant differences in the JAAM DIC score and the variables adopted in the scoring system between survivors and nonsurvivors. The logistic regression analyses showed the JAAM DIC score and prothrombin time ratio on the day of DIC diagnosis to be predictors of patient outcome. The patients who simultaneously met the ISTH DIC criteria demonstrated twice the incidence of multiple organ dysfunction (61.1 vs. 30.5%, p < .0001) and mortality rate (34.4 vs. 17.2%, p = .0015) compared with those without the ISTH DIC diagnosis. Conclusions:This prospective survey demonstrated the natural history of DIC patients diagnosed by the JAAM DIC diagnostic criteria in a critical care setting. The study provides further evidence of a progression from the JAAM DIC to the ISTH overt DIC.
A NEW EURYPTERID LAGERSTÄTTE FROM THE UPPER SILURIAN OF PENNSYLVANIA

ABSTRACT Eurypterids are generally rare in the fossil record, but occasionally occur in abundance. The genus Eurypterus, in particular, is well known from certain upper Silurian Lagerstätten of the northern Appalachian basin (New York and Ontario), but occurs far less frequently in the central and southern Appalachian basin (Pennsylvania, Maryland, and West Virginia, respectively). The recent discovery of an exceptionally preserved mass assemblage of Eurypterus in the upper Tonoloway Formation (upper Ludlow–Přídolí) of Pennsylvania provides new information on the behavior and life habitat of the genus in this region. Eurypterids at this locality are found in thinly laminated, calcareous shale deposited within the lower intertidal to shallow subtidal zone of a coastal mudflat or sabkha. Rare associated fauna of limited diversity, and evaporitic and desiccation features in associated beds, suggest a stressed environment with variable salinity and possible hypoxic conditions. Most eurypterids are disarticulated and fragmentary, but several fully articulated, exceptionally preserved specimens are present. Exoskeletal features and taphonomic indices values indicate a molt rather than death assemblage, and the presence of arthropod trackways suggests that Eurypterus sp. may have molted en masse in the vicinity of the burial site. Sequence stratigraphic interpretation of the site suggests that preservation of eurypterid remains is the result of occupation of ephemeral environmental (salinity/oxygen) conditions during a transgression. The occurrence of this new Lagerstätte within the upper Silurian succession of the central Appalachians, an interval which had heretofore yielded only rare, fragmentary remains, indicates that eurypterids were more prevalent in this region than previously thought.
Quantitative EEG Neurometric Analysis–Guided Neurofeedback Treatment in Postconcussion Syndrome (PCS): Forty Cases. How Is Neurometric Analysis Important for the Treatment of PCS and as a Biomarker?

Postconcussion syndrome (PCS) has been used to describe a range of residual symptoms that persist 12 months or more after the injury, often despite a lack of evidence of brain abnormalities on magnetic resonance imaging and computed tomography scans. In this clinical case series, the efficacy of quantitative EEG–guided neurofeedback in 40 subjects diagnosed with PCS was investigated. Overall improvement was seen in all the primary (Symptom Assessment-45 Questionnaire, Clinical Global Impressions Scale, Hamilton Depression Scale) and secondary measures (Minnesota Multiphasic Personality Inventory, Test of Variables for Attention). The Neuroguide Traumatic Brain Index for the group also showed a decrease. Thirty-nine subjects were followed up long term with an average follow-up length of 3.1 years (CI = 2.7-3.3). All but 2 subjects were stable and were off medication. Overall neurofeedback treatment was shown to be effective in this group of subjects studied.
A Comparison of Three Extraction Methods for Phenolic Compounds and Antioxidant Activities from Moringa oleifera Leaves

In our study, the proximate analysis of dried Moringa oleifera leaves was firstly evaluated; then three different extracts were obtained by using different extraction techniques including agitation (AG), sonication (SO) and aqueous (AQ) were used to investigate the phytochemical screening (total phenolic content (TPC) and total flavonoid content (TFC)) and antioxidant activities (2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, 2,2′-azino-bis-3-ethylbenzothiazoline6-sulphonic acid (ABTS) assay, ferric reducing ability of plasma (FRAP) assay and reducing power (RP) assay) of the Moringa leaves in order to find the best extraction method for further study. Finally, the presence of phenolic compounds was analyzed using high performance liquid chromatography (HPLC) analysis. The results showed Moringa leaves contained a large amount of carbohydrate and protein; while there was only small amount of lipid. The highest extraction yield was obtained aqueous method at 62.22 ± 0.68%. For phytochemical screening, the agitation presented the best results for highest total phenolic content at 74.87 ± 0.19 mg Gallic acid equivalent (GAE)/g dry weight and highest total flavonoid content at 18.46 ± 0.25 mg Catechin equivalent (CE)/g dry weight, respectively. Besides, agitation method also showed significantly different in antioxidant abilities compared to the others. Due to dose-dependent manners of all extracts to scavenging DPPH and ABTS free radicals; it strongly reconfirmed the correlation of TPC to antioxidant abilities. Thus, finding the most effective extraction method for highest yield and phenolic compound content is beneficial for achieving greater antioxidant ability and can be applied in further works in the food and pharmaceutical industry.