Miracle-dz/UniFAR-FTUs huggingface dataset:
Abstract P4-13-10: DoBRCA1andBRCA2mutation carriers have an earlier natural menopause than their non-carrier relatives: A study from the Kathleen Cuningham Foundation Consortium For Research Into Familial Breast Cancer (kConFab).:

BACKGROUND: Limited data from the in vitro fertilisation setting suggest that germline BRCA1 mutations are associated with occult primary ovarian insufficiency. We examined whether carriers of a BRCA1 or BRCA2 mutation have earlier natural menopause than their non-carrier relatives. PATIENTS AND METHODS: Eligible subjects were female mutation carriers and tested non-carriers from families segregating BRCA1 or BRCA2 mutations enrolled in KConFab. Women who had not been tested for the family mutation and those with primary amenorrhoea were excluded. Data were self-reported using uniform questionnaires completed at cohort entry and every 3 years thereafter. Age at natural menopause (NM) was defined as age at cessation of menses for ≥ 12 months in the absence of other causes. Cox proportional hazards analysis was applied, modelling time in years from birth to NM, adjusting for year of birth (continuous), body mass index (continuous), ever regular cigarette smoking (no, yes), and ever regular alcohol use (no, yes). Analysis time was censored at the earliest of: cessation of menses for 12 months in the absence of other reasons (natural menopause), last follow-up, pelvic surgery including oophorectomy or hysterectomy, commencement of hormone replacement therapy or Tamoxifen as a risk reducing medication, or any cancer diagnosis. Hazard ratios (HR) were estimated as a measure of how rapidly mutation carriers reach natural menopause relative to non-carriers. RESULTS: No difference was observed in the rate at which carriers and non-carriers went through natural menopause, regardless of the gene mutated in the families. The adjusted hazard ratio estimates were 0.97, (95% CI 0.69–1.35, p = 0.8) for BRCA1 mutation carriers versus non-carriers and 1.02, (95%CI 0.72–1.44, p = 0.9) for BRCA2 mutation carriers versus non-carriers. CONCLUSIONS: This study found no evidence that BRCA1 and BRCA2 mutation carriers do reach natural menopause at an earlier age than their non-carrier relatives. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-13-10.
Do Trajectories of At-Home Dementia Caregiving Account for Burden After Nursing Home Placement? A Growth Curve Analysis

Transitioning to the nursing home setting is a complex process for family caregivers of older adults with dementia. While nursing home placement (NHP) can alleviate certain caregiving responsibilities, new stressors can also emerge. In the present study, the researchers examined how care-related factors can change leading up to NHP and how these factors influence caregiver outcomes following NHP. A sample of 634 family dementia caregivers (n = 634) were surveyed at three six-month intervals prior to NHP and once during the 12 month period following institutionalization. Growth curve modeling revealed dynamic changes in certain factors leading up to NHP (e.g., caregivers' perceived health), while other factors remained stable (e.g., caregiver burden). Several factors emerged as significant predictors of caregiver burden following NHP, including pre-placement burden and adult day service utilization. For geriatric social workers, these findings may be useful in assessing family caregivers, and in the development and utilization of appropriate interventions.
Health Functional Food Use and Related Variables Among the Middle-Aged in Korea

Various types of health functional foods (HFF) are popularly used among middle-aged. We surveyed 946 middle-aged in Korea for HFF use and significant variables for their HFF use including demographic characteristics, health related variables and nutritional beliefs. The use prevalence of HFF was 58.9%, and among all types of HFF, red ginseng products were taken most frequently, followed by nutritional supplements, ginseng products > mushroom products. HFF was taken more frequently in subjects from high monthly family income (p
The Role of the Social Worker in the Adult Critical Care Unit: A Systematic Review of the Literature

Social workers provide care to patients and families in the adult critical care unit. We conducted a systematic review of the literature to more clearly identify the role of the social worker practicing in the intensive care unit. We conducted a comprehensive search of the literature using the Pubmed, Embase, ISI, Scopus, and Social Work Abstracts databases using the terms “intensive care,” “critical care,” and “social work. ” Articles were selected for review if they met the following criteria: formal studies or opinion papers whose primary focus was the role or scope of practice of the social worker in the adult critical care unit. Articles were selected and reviewed independently by two social work investigators. Our search retrieved 550 potentially relevant articles. Twelve full-text articles were deemed eligible for abstracting. Three of the articles were studies that examined different aspects of social work practice including implementation of a family assistance program, social work response to anxiety levels of families in critical care and common activities of critical care social workers. Nine articles were primarily opinion pieces. All of the opinion articles described psychosocial support and counseling as a primary role of critical care social work. Other frequently identified roles were crisis intervention, psychosocial assessment, facilitating communication, end-of-life care, and practical assistance. There is little empiric data describing the role of the critical care social worker. Consistent themes from the articles identified include the role of social workers as counseling professionals, facilitators of communication, and resource agents. Further research to identify formal assessment tools and outcome studies of specific counseling techniques will provide important information for best practice guidelines in this area.
Low Social Support and Further Risk Factors for Nicotine Abuse in Childhood and Adolescence in Germany

The health hazards of tobacco consumption are well known; numerous prevention programs exist, but knowledge of risk factors for starting to smoke is scarce. This study addressed the question if school-related factors influence smoking behavior in 7–17-year-old pupils. A cross-sectional study including 2459 pupils of schools in Rhineland-Palatinate, Germany, was conducted. Roughly every twentieth child (n = 135, 4.5%) had smoked at least once. In the multivariate model the probability of smoking was associated with older age, being male, not being content, and having inadequate family support, as well as with feeling unfairly treated at school. These findings suggest the imposition of gender- and age-adequate prevention with a focus on social support from school and parents to decrease the number of juvenile smokers.
Fibromyalgia Associated Syndromes

SUMMARY Objectives: To describe the syndromes that share overlapping clinical features with fibromyalgia [FMS]. Findings: There are a number of semantic terms currently used to described systemic syndromes that share overlapping features with FMS. These include chronic fatigue syndrome, multiple chemical sensitivity, somatoform disorders, and Gulf War Illnesses. There are also a number of regional or “organ-specific” syndromes that overlap with these conditions that have as their common features regional pain, with and without dysfunction of internal organs. Conclusions: In aggregate, chronic multisymptom illnesses such as FMS are extremely common. Hallmarks of these syndromes include non-nociceptive pain, fatigue, memory difficulties, and dysfunction of visceral organs.
Postoperative Complications After Gynecologic Surgery

OBJECTIVE: To estimate the association of age, medical comorbidities, functional status, and unintentional weight loss (as a marker of frailty) with postoperative complications in women undergoing major gynecologic surgery. METHODS: We conducted a cross-sectional analysis of the American College of Surgeons National Surgical Quality Improvement Program 2005–2009 participant use data files to analyze gynecologic procedures. The primary outcome was a composite of 30-day major postoperative complications. RESULTS: A total of 22,214 women were included in our final analysis. The overall prevalence of composite 30-day major postoperative complications was 3.7% (n=817). Age 80 years or older (adjusted odds ratio [OR] 1.8, 95% confidence interval [CI] 1.25–2.58), dependent functional status (adjusted OR 2.37, 95% CI 1.53–3.68), and unintentional weight loss (adjusted OR 2.49, 95% CI 1.48–4.17) were significantly associated with postoperative morbidity after adjusting for diabetes mellitus (adjusted OR 1.44, 95% CI 1.15–1.79), known bleeding disorder (adjusted OR 2.29, 95% CI 1.49–3.52), morbid obesity (adjusted OR 1.77, 95% CI 1.45–2.17), ascites (adjusted OR 3.27, 95% CI 2.18–4.90), preoperative systemic infection (adjusted OR 3.02, 95% CI 2.03–4.48), procedures for gynecologic cancer (adjusted OR 1.60, 95% CI 1.27–2.0), disseminated cancer (adjusted OR 2.57, 95% CI 1.64–4.03), emergency procedures (adjusted OR 1.82, 95% CI 1.18–2.79), operative time more than 4 hours compared with less than 1 hour (adjusted OR 2.91, 95% CI 2.18–3.89), and wound class 4 compared with wound class 1 (adjusted OR 4.28, 95% CI 1.82–10.1). CONCLUSION: Age 80 years or older, medical comorbidities, dependent functional status, and unintentional weight loss are associated with increased major postoperative complications after gynecologic procedures. LEVEL OF EVIDENCE: III
Social Challenges for Children With Hemophilia: Child and Parent Perspectives

The impact of pediatric chronic illness on peer relations and social adjustment in nine school-aged boys with hemophilia was examined using qualitative interview methods. Literature on boys' psychosocial development provided a theoretical perspective to interpret findings. Three main themes emerged from the interviews: Awareness of difference, efforts to conceal difference, and efforts to connect with peers and friends. Findings suggest that hemophilia may be a socially stigmatizing condition for many boys because it limits gender-typical interactions with same-sex peers. Recommendations are offered for research on interventions to assist children in communicating with peers about their health condition and to involve close friends and parents in such interventions.
Health Risks of Separated or Divorced Over-Indebted Fathers: Separation From Children and Financial Distress

The study examines over-indebted fathers after separation/divorce with respect to health-related lifestyles/state of health. A cross-sectional survey was conducted among over-indebted persons in Germany 2006/2007 (response rate 39.7%). Fathers in complete families (n = 73; M = 37 years) and single mothers (n = 72; M = 33.5 years) served as comparison groups to the separated fathers (n = 59; M = 37 years). Risks of depressive mood, unhealthy nutrition, and hypertension were higher compared to fathers in complete families. Tobacco use and low health awareness proved to be higher than among both comparison groups. The findings indicate problematic health-related behavior and health status among separated over-indebted fathers, and suggest recognizing them as a high risk group within social work.
Characteristics of Youth in the U.S. Receiving Services From a Patient-Centered Medical Home (PCMH)

Using data from the 2007 National Survey of Children's Health, this study identifies the characteristics of those youth served and not served by a medical home. Although Patient-Centered Medical Homes (PCMHs) are being piloted with Medicaid clients, these national data indicate that adolescents are least likely to receive services from a medical home as are youth of color, those with family income levels between 0–99% of the Federal poverty level, and those currently uninsured. These populations, as well as children with special health care needs and youth in the child welfare system, however, may be those most likely to benefit from a PCMH.
Octreotide lessens peritoneal injury in experimental encapsulated peritoneal sclerosis model

Aim: Encapsulated peritoneal sclerosis is characterized by neoangiogenesis and fibrosis. Octreotide, a somatostatin analogue is a well‐known antifibrotic, antiproliferative and anti‐angiogenic agent. The aim of the study is to evaluate the effects of octreotide in encapsulated peritoneal sclerosis‐induced neoangiogenesis and fibrosis and compare the results with resting.
Moving an Evidence-Based Intervention Into Routine Mental Health Care: A Multifaceted Case Example

Many evidence-based interventions fail to translate into routine care for individuals experiencing significant mental health disorders. Moving the evidence-based intervention from the controlled research settings to the broader mental health systems is an ongoing challenge for administrators and practitioners in the mental health delivery network. In the United States, the movement to bring evidence-based mental health interventions into the public mental health system to enhance consumer recovery and improve outcomes has been a major thrust of federal and state efforts over the past 10 years (IOM, 2006; New Freedom Commission on Mental Health, 2003; Michigan Mental Health Commission, 2004; U.S. Department of Health and Human Services, 1999). Using a multifaceted case example, this article will address one state's efforts to implement an evidence-based intervention, Family Group Psychoeducation (FPE), into routine care for individuals living with schizophrenia and their families. The Consolidated Framework for Implementation Research (CFIR) (Damshcroder et al., 2009) guides the discussion of the dissemination efforts. This CFIR framework involves examining five major domains: intervention characteristics, outer setting, inner setting, characteristics of the individuals involved, and the process of implementation
Invasive pneumococcal pneumonia is the major cause of paediatric haemolytic‐uraemic syndrome in Taiwan

Aim: Streptococcus pneumoniae‐associated haemolytic uraemic syndrome (SP‐HUS) is a major concern of paediatric acute renal failure in Taiwan; it leads to significant morbidity and mortality during the acute phase and to long‐term morbidity after an acute episode.
The Challenges of Health Care Reform for Hospital Social Work in the United States

This article examines the potential impact of the Patient Protection and Affordable Care Act (ACA) of 2010 on the practice of hospital social work in the United States and its implications for social work education and training. It briefly traces the history of hospital social work, outlines some contemporary issues in the health care field, particularly those that create persistent health disparities, summarizes the major provisions of the Act that have implications for social work practice, and discusses how social workers in hospital settings might respond effectively to the changes produced by the legislation.
Unverifiable Accomplishments and Publications on Applications for Gynecologic Oncology Fellowships

OBJECTIVE: Selection of physicians for fellowships in obstetrics and gynecology subspecialties has become increasingly competitive. The number and quality of research publications is an important factor in the selection process. We sought to estimate the incidence of unverifiable publications among gynecologic oncology fellowship applicants. METHODS: We reviewed the applications to a single gynecologic oncology fellowship program during 2004–2008. Articles and book chapters reported as published, in press, submitted, or in progress were searched for systematically by three reviewers using PubMed and Google. &khgr;2 analysis was used to evaluate associations between demographic factors and unverifiable publications. RESULTS: Two hundred forty-three applications met the inclusion criteria. Of the 35 applicants who listed membership in Alpha Omega Alpha, four (11%) were not listed on the organization's web site as inductees. Of the 464 articles reported as published or in press, only 387 (83%) could be verified. Of the 148 applicants who reported at least one published or in press article, 44 (30%) had at least one unverifiable publication. On multivariable analysis, only male gender increased the likelihood of unverifiable (“ghost”) publications (odds ratio 2.1, 95% confidence interval 1.1–4.1). Of the 282 manuscripts reported as submitted or in progress, only 126 (45%) were published. Of the 124 applicants who reported at least one submitted or in progress manuscript, 88 (71%) had at least one unverifiable manuscript. CONCLUSION: The proportion of unverifiable publications listed on gynecologic oncology fellowship applications is concerning. Stringent review of applications before interview invitations and match list submission is warranted. LEVEL OF EVIDENCE: III
Effect of gastric acid suppression with pantoprazole on the efficacy of calcium carbonate as a phosphate binder in haemodialysis patients

Aim: Metallic phosphate binders require acidity to dissociate to the free metallic ion and bind phosphorus. Altered gastric acidity may, therefore, influence phosphate‐binding efficacy. We evaluated the clinical effect of pantoprazole on the efficacy of calcium carbonate phosphate binders in haemodialysis patients.
Agentes causantes de diarrea en niños menores de 5 años en Tunja, Colombia

Objetivos Determinar la prevalencia y tipo de agentes infecciosos causantes de EDA en una muestra de ninos menores de 5 anos que consultaron a IPS de Tunja durante el ano 2004. Materiales y Metodos Estudio de corte transversal, la informacion se recogio mediante aplicacion de una encuesta a 129 ninos menores de 5 anos afectados de EDA. Adicionalmente se recogio una muestra de heces, en las consultas externas del Hospital San Rafael y Clinica Saludcoop de Tunja. Resultados Se encontro Rotavirus en 48,1 %, Shigella 0,8 %, E. coli 13,9 %; Campylobacter 2,3 %; Giardia lamblia 12,4 %; E. histolytica 7 %; en 15,5 % de casos no se identifico agente causal. La asociacion es creciente con la edad para Rotavirus (p Conclusion Rotavirus es el mayor agente causal de EDA en menores de 1 ano, y en general, en menores de 5 anos. Las prevalencias encontradas coinciden con lo reportado en estudios realizados en Facatativa, Bogota, Santander, Manizales y Choco; tambien con estudios adelantados en Venezuela, Peru y Mexico.
Addressing the Spiritual Needs of American Indians: Predictors of Satisfaction

Spirituality is instrumental to health and wellness in many American Indian (AI) cultures. Although the Joint Commission requires spiritual assessments to identify and address clients’ spiritual needs during hospitalization, little is known about the operationalization of this process for American Indians (AIs). To address this gap in the literature, the present study employed a national sample of AIs (N = 1,281) to identify predictors of satisfaction with the manner in which their spiritual needs were addressed. The results suggest the discharge process, physicians, room quality, and nurses play important roles in satisfactorily addressing AIs’ spiritual needs. Of these, the discharge process had the largest effect on satisfaction, underscoring the salience of social workers in addressing the spiritual needs of hospitalized AIs.
The determinants of self-medication: Evidence from urban Vietnam

ABSTRACT This study examines the primary determinants of self-medications among urban citizens in Ho Chi Minh City, Vietnam using survey data. Employing logistic models, the article finds that the probability of self-medication is positively associated with the respondents’ high school degree or vocational certificate, married status, and income while it is negatively related to employed status, the number of children, the geographical distance from home to the nearest hospital, doing exercise, and living in a central region. Meanwhile, using Poisson models the article finds that the frequency of self-medication is positively associated with the respondents’ high school and vocational, married, income, and chronic disease while the frequency of self-medication is adversely related to male, employed, children number, distance, being close to health professional and central areas.
Revised terminology for cervical histopathology and its implications for management of high-grade squamous intraepithelial lesions of the cervix.

In March 2012, the College of American Pathologists and American Society for Colposcopy and Cervical Pathology, in collaboration with 35 stakeholder organizations, convened a consensus conference called the Lower Anogenital Squamous Terminology (LAST) Project. The recommendations of this project include using a uniform, two-tiered terminology to describe the histology of human papillomavirus-associated squamous disease across all anogenital tract tissues: vulva, vagina, cervix, penis, perianus, and anus. The recommended terminology is "low-grade" or "high-grade squamous intraepithelial lesion (SIL). " This terminology is familiar to clinicians, because it parallels the terminology of the Bethesda System cytologic reports. Biopsy results using SIL terminology may be further qualified using "intraepithelial neoplasia" (IN) terminology in parentheses. Laboratory p16 tissue immunostaining is recommended to better classify histopathology lesions that morphologically would earlier have been diagnosed as IN 2. p16 is also recommended for differentiating between high-grade squamous intraepithelial lesions and benign mimics. The LAST Project recommendations potentially affect the application of current guidelines for managing cervical squamous intraepithelial lesions. The authors offer interim guidance for managing cervical lesions diagnosed using this new terminology with special attention paid to managing young women with cervical high-grade squamous intraepithelial lesions on biopsy. Clinicians should be aware of the LAST Project recommendations, which include important changes from prior terminology.
The effect of advocacy for overcoming stigma on posttraumatic growth: Focusing on childhood cancer survivors

ABSTRACT The aim of this study was to investigate both strategies for coping with stigma and the effects of participating in advocacy. The participants were childhood cancer survivors who had been diagnosed before the age of 18 years who had completed treatment. An embedded-design mixed-methods approach was used with 30 interview scripts, and 145 survey results were collected. Coping strategies for the stigma of cancer were “secrecy, avoid stereotypes, and discrimination” and “disclosure of medical history. ” Participation in advocacy confirmed self-worth, helped in achievement, and promoted social skills. Quantitative analysis showed that greater advocacy participation was associated with higher levels of posttraumatic growth. This study could provide support for advocacy among childhood cancer survivors by demonstrating its positive effects.
Women’s strategies for coping with the impacts of domestic violence in Kyrgyzstan: A grounded theory study

ABSTRACT This paper provides an account of the adverse impacts of domestic violence on women in Kyrgyzstan and develops a grounded theory of coping among survivors of abuse. The results indicate that women adopt a range of strategies to prevent, avert, and minimize anticipated violence. Two key aspects of coping appeared in the narratives: 1) maintaining the status quo and 2) developing agency to resist the abuse. The results suggest that Government and nongovernmental organizations must take additional action to draw women to formal violence prevention services. Providing professional help at several levels (e.g., clinical, community, and societal) and promoting problem-focused strategies as part of therapeutic intervention are essential.