Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality of labeling on dispensed medicines and associated factors among public health care facilities in Bahir dar city , Northwest Ethiopia

Purpose: To determine the quality of labeling on dispensed medicines and identify the associated factors among public health facilities in Bahir Dar city. Methods: A cross sectional study was conducted from August 5 to 20, 2013 at selected health care facilities in Bahir Dar city. Simple random sampling and systematic random sampling techniques was used to select health facilities and dispensing encounters respectively. Data was collected from non participatory observations of the drug dispensing process using check list. Data was entered into EPI Info (version 3.5.2) and analyzed using SPSS version 16. Bivariate and multivariate regression analysis was computed to test the strength of association and level of significance. P-value <0.05 was considered as statistical significant. Results: A total of 400 dispensing encounters and 636 drugs dispensed were observed in eight (8) outpatient pharmacies. The percentage of drugs adequately labeled was 32.2%. Drugs adequate labeling score was higher in private health facilities (39.3%) compared to government health facilities (25.83%). The name, strength and dosage form of the drugs were labeled in 95.6%, 90% and 85.8% respectively. Differences in dispenser work experiences (AOR = 2.99, CI: 1.67 – 5.37), average dispensing time (AOR = 6.22, CI: 3.08-12.57), average consultation time (AOR=3.42, CI: 1.64-7.13), level of health facility (AOR = 4.31, CI 1.94 – 9.59) and type of health facilities (AOR = 4.29, CI 1.72 – 10.66) were found to be independently associated factors for quality of labeling score. Conclusion: The quality of labeling on dispensed medicines was not adequate. Dispenser work experiences, average dispensing time, average consultation time, level of health facility and type of health facilities were found to be significant factors for quality of labeling score. Therefore, attention should be given to strong skill development, increasing manpower and implementation of regular monitoring for the application of dispensing ethics.
Theophylline versus terbutaline in treating critically ill children with status asthmaticus: A prospective, randomized, controlled trial

Objective: To compare the efficacy of theophylline, terbutaline, or theophylline combined with terbutaline treatment in critically ill children with status asthmaticus who are already receiving continuous nebulized albuterol and intravenous corticosteroids. Design: Randomized, prospective, controlled, double-blind trial. Setting: Pediatric intensive care unit of a tertiary-care children’s medical center. Patients: Forty critically ill children between the ages of 3 and 15 yrs with impending respiratory failure secondary to status asthmaticus. Interventions: All patients received intravenous methylprednisolone and continuous nebulized albuterol. The three study groups received theophylline plus placebo (group 1), terbutaline plus placebo (group 2), or theophylline and terbutaline together (group 3). Measurements and Main Results: Differences in baseline characteristics, change in clinical asthma score over time, length of pediatric intensive care unit stay, and incidence of adverse events were determined. The three study groups were similar in age, gender, race, asthma severity, and treatment. There were no differences in clinical asthma score over time, length of pediatric intensive care unit stay, or incidence of adverse events between the three groups, with the exception of a higher incidence of nausea in children in group 3. The median hospital cost of medication and theophylline blood levels was significantly lower in group 1 compared with groups 2 and 3 ($280 vs. $3,908 vs. $4,045, respectively, p < .0001). Conclusions: Theophylline, when added to continuous nebulized albuterol therapy and intravenous corticosteroids, is as effective as terbutaline in treating critically ill children with status asthmaticus. The addition of theophylline to baseline therapy is more cost-effective when compared with terbutaline alone or terbutaline and theophylline together. Theophylline should be considered for use early in the management of critically ill asthmatic children.
Regional brain atrophy and functional disconnection across Alzheimer's disease evolution

Objective To assess the contribution of regional grey matter (GM) atrophy and functional disconnection in determining the level of cognitive decline in patients with Alzheimer's disease (AD) at different clinical stages. Methods Ten patients with amnesic mild cognitive impairment (a-MCI), 11 patients with probable AD and 10 healthy controls were recruited. T1 volumes were obtained from each subject and postprocessed according to an optimised voxel based morphometry protocol. Resting state functional MRI data were also collected from the same individuals and analysed to produce connectivity maps after identification of the default mode network (DMN) by independent component analysis. Results Compared with healthy controls, both AD and a-MCI patients showed a similar regional pattern of brain disconnection between the posterior cingulate cortex (PCC) and the medial prefrontal cortex and the rest of the brain. Conversely, the distribution of GM atrophy was significantly more restricted in a-MCI than in AD patients. Interestingly, the PCC showed reduced connectivity in a-MCI patients in the absence of GM atrophy, which was, in contrast, detectable at the stage of fully developed AD. Conclusions This study indicates that disconnection precedes GM atrophy in the PCC, which is a critical area of the DMN, and supports the hypothesis that GM atrophy in specific regions of AD brains likely reflects a long term effect of brain disconnection. In this context, our study indicates that GM atrophy in PCC accompanies the conversion from MCI to AD.
Research anxiety and students' perceptions of research: An experiment. Part I. Effect of teaching Kuhlthau's ISP model

This two-part study investigates the effect of a 30-minute presentation of Carol Kuhlthau's Information Search Process (ISP) model on students' perceptions of research and research paper anxiety. An experiment was designed to collect both quantitative and qualitative data during a semester. An upper division undergraduate course, Technical and Professional Writing, with four sections participated in the experiment in fall 1999. A survey instrument, the Research Process Survey (RPS), was developed to collect data about students' feelings and thoughts at the onset of their course research project (pretest) and at the completion of the project (posttest). A standard anxiety test (STAI Y-1) was adopted to measure anxiety levels during pretest and posttest sessions and at two additional points between. Two of the four sections heard a guest presentation of the ISP model as treatment after the pretest; the other two sections heard a different guest speak about career experiences as a technical writer (a placebo talk). The results of this experiment are reported in two articles according to the nature of the collected data. This article reports on results of the quantitative analysis. Four hypotheses were proposed to examine the effects on awareness of cognitive aspects, awareness of affective aspects, level of anxiety, and satisfaction with research. One hypothesis was supported. A significant change in anxiety levels was measured (p = 0.5). Although statistical tests did not reject three null hypotheses, positive trends in change as a result of the ISP model were identified. A second article reports on results of qualitative analysis of the texts that participants wrote about a memorable past research experience and about the current research experience.
COINCIDENCE AND FIXED POINT THEOREMS OF INTUITIONISTIC FUZZY MAPPINGS WITH APPLICATIONS

The purpose of this paper is to prove some new common fixed point and coincidence point theorems for a pair of intuitionistic fuzzy mappings on a complete metric linear space in association with the Hausdorff metric as well as d∞ metric on the family of intuitionistic fuzzy sets (IFS). Moreover, as an application, in function space C [a, b], an existence of coincidence theorem for a family of nonlinear integral equations has been established. Some illustrative examples which demonstrate the validity of the hypothesis and novelty of our main results are presented
E ethical leadership , leader-follower relationship and performance : a study in a telecommunications company JEANE RODRIGUES

Purpose: Analyze the influence of ethical leadership on the relationship between leaders and followers, as well as its consequences for individual performance, commitment to work goals, and organizational citizenship. Originality/gap/relevance/implications: Although ethics in leadership is supposed to promote positive consequences in the work context, its association with performance and other relevant aspects in the business environment – such as the commitment to goals – has not yet been empirically studied. The present research contributes by filling this gap, therefore expanding the knowledge about the implications of ethical leadership in Brazil. Key methodological aspects: A survey was conducted in a multinational telecommunications company, with a sample of 161 store clerks and 15 managers responsible for the sales units located in the city of Rio de Janeiro. The statistical analysis was done using the software SPSS, through multiple regression analyses conducted with the variables studied. Summary of key results: The results corroborate the benefits of ethical leadership. They show a positive association between ethical leadership and both the quality of the leader-follower relationships and employee performance. Key considerations/conclusions: The research suggests that ethical leadership seems to have a positive impact on work productivity, by building a better relationship with employees. Therefore, based on the findings, it is possible to recommend specific actions in leadership development programs, calling attention to the importance of discussing ethical dilemmas, behaviors, and models of practice.
Early detection and integrated care for adolescents and young adults with severe psychotic disorders: rationales and design of the Integrated Care in Early Psychosis Study (ACCESS III)

The Integrated Care in Early Psychosis (ACCESS III) Study examined the efficacy and cost‐effectiveness of a combined intervention consisting of strategies to improve early detection and quality of care (integrated care including therapeutic assertive community treatment) in adolescents and young adults in the early phase of a severe psychotic disorder from 2011 to 2014.
Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade: A Critical Role of Interferon-&ggr;

Dendritic cell-derived exosomes (Dex) are nanovesicles bearing major histocompatibility complexes promoting T-cell−dependent antitumor effects in mice. Two phase I clinical trials aimed at vaccinating cancer patients with peptide-pulsed Dex have shown the feasibility and safety of inoculating clinical-grade Dex, but have failed to show their immunizing capacity. These low immunogenic capacities have led us to develop second-generation Dex with enhanced immunostimulatory properties. Here, we show that interferon-&ggr; is a key cytokine conditioning the dendritic cell to induce the expression of CD40, CD80, CD86, and CD54 on Dex, endowing them with direct and potent peptide-dependent CD8+ T-cell-triggering potential in vitro and in vivo. In this study, we describe the clinical grade process to manufacture large-scale interferon-&ggr;-Dex vaccines and their quality control parameters currently used in a phase II trial.
Phenotypic and genetic parameter estimates for grasscutter production traits . 1 . ( Co ) variance components and heritability

1 Department of Animal Science Education, College of Agriculture Education, University of Education, Winneba, P.O. Box 40, Mampong-Ashanti, Ghana. 2 Department of Animal Science, College of Agriculture and Consumer Sciences, University of Ghana, P.O. Box LG 571, Legon, Accra, Ghana. 3 Animal Research Institute, Council for Scientific and Industrial Research, P.O. Box AH 20, Achimota, Accra, Ghana. 4 Department of Animal Science, College of Agriculture and Life Sciences, North Carolina State University, Campus Box 7621/232B Polk Hall, Raleigh NC 27695-7621, North Carolina, USA
Mediating Effect of Academic Engagement in Relationship between Academic Self-Efficacy and Academic Achievement among Adolescent in Tehran

Studies have shown the academic self-efficacy and other psychological influences account for considerable variance in academic achievement through a range of meditational pathway, although no research to date has tested the meditational relationships identified. The present study investigated the relations among academic self-efficacy and academic engagement on academic achievement of 500 students aged 12-18 years in Tehran-Iran. The Morgan & Jink academic self-efficacy scale and Short, Feleming, Guiling, & Ropper academic engagement scale were administered to participants prior to academic achievement being assessed using cumulative grade point average (CGPA). The results of a 3-step multiple regression analysis and Sobel-test indicated that the positive effects of academic self-efficacy on academic achievement is significantly mediated by academic engagement. [Zahra Houshmand Neghabi, Sudabeh Morshedian Rafiee. Mediating Effect of Academic Engagement in Relationship between Academic Self-Efficacy and Academic Achievement among Adolescent in Tehran. J Am Sci 2013;10(5s):393-399]. (ISSN: 1545-1003). http://www.americanscience. org. 71 Keyword: Academic Self-Efficacy, Academic Engagement, Academic Achievement
Lysine methyltransferase Smyd 2 regulates Hsp 90-mediated protection of the sarcomeric titin springs and cardiac function ☆

a Dept. of Cardiovascular Physiology, Ruhr University Bochum, MA 03/56, D-44780 Bochum, Germany b Cardiovascular Physiology, University Clinic Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany c Dept. of Internal Medicine II, University Hospital Ulm, Albert-Einstein-Allee 23, D-89081 Ulm, Germany d Heart Center, University Medicine Göttingen, Robert-Koch-Str. 40, D-37075 Göttingen, Germany
Fusion imaging-guided radiofrequency ablation for hepatocellular carcinomas not visible on conventional ultrasound.

OBJECTIVE The objective of our study was to assess whether fusion imaging of conventional ultrasound and liver CT or MR images can improve the conspicuity of lesions and feasibility of percutaneous radiofrequency ablation (RFA) for the treatment of hepatocellular carcinomas (HCCs) not visible on ultrasound. Whether peritumoral anatomic landmarks can be used for the placement of an electrode in HCCs not visible on ultrasound even after image fusion was also evaluated. MATERIALS AND METHODS Planning ultrasound for percutaneous RFA was performed using conventional ultrasound first and then using fusion imaging later during the same session. The visibility of HCCs and feasibility of RFA on conventional ultrasound and on fusion imaging were assessed. We evaluated how many HCCs initially not visible on conventional ultrasound could be visualized and ablated after applying the fusion imaging technique. One hundred twenty HCCs not visible on conventional ultrasound in 96 patients were included. RESULTS When fusion imaging was applied, 38 of the 120 (31.7%) HCCs that were initially not visible could be seen and RFA was feasible. Among the remaining 82 HCCs still not visible after image fusion, 26 (31.7%) were ablated under the guidance of fusion imaging the technique based on peritumoral anatomic landmarks. Overall, 64 of 120 (53.3%) HCCs (59.4%, 57 of 96 patients) not visible on conventional ultrasound could be ablated under the guidance of the fusion imaging technique. CONCLUSION Fusion imaging can improve the conspicuity of HCCs and the feasibility of percutaneous RFA of HCCs not visible on conventional ultrasound. Peritumoral anatomic landmarks can be used for electrode placement in HCCs that are still not visible even after image fusion.
An integrated fuzzy MCDM approach , and analysis , to the evaluation of the financial performance of Iranian cement companies

In today's highly competitive environment, suitable appraisal of a company’s performance is of vital importance not only for the company but also for its suppliers and customers. The main objectives of this study were to analyze the financial ratios of Iranian cement-producing companies and to develop a fuzzy model to evaluate financial performance. The proposed fuzzy approach is based on fuzzy analytical hierarchy process (FAHP) and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method. In contrast to other studies in the literature, in the present study the FAHP method was used in determining the weightage of criteria by decision makers, and the ranking of the companies was determined by the TOPSIS method. The proposed combined method was used to evaluate the performance of eight Iranian cement companies listed in the Tehran Stock Exchange using data from their financial tables, and subsequent ranking of these companies. The final results of the analysis revealed performance ranking of companies Sabhan, Sarab, Sedasht, Safar, Sekaroun, Sakarma, Sanir and Sahrmoz with priority scores of 0/55, 0/51, 0/50, 0/49, 0/42, 0/37, 0/36 and 0/33, respectively. The results indicate an overall performance ranking because the weights of the criteria were determined by decision makers with different experiences, positions and proficiencies. If it is desired, it is possible to make an evaluation only for creditors, investors or shareholders, however, in such cases the weights of the criteria will vary and the ranking of the companies can change. The proposed method can also be applied tothe evaluation of companies in other sectors. [Moghimi R, Anvari A, Amoozesh N, Ghesary T. An integrated fuzzy MCDM approach, and analysis, to the evaluation of the financial performance of Iranian cement companies. Life Sci J 2013;10(5s):570-586] (ISSN:1097-8135). http://www.lifesciencesite. com. 101
Chapter 2 Public Choice : An Introduction 1

Public Choice has been defined as the application of the methodology of economics to the study of politics. This definition suggests that public choice is an inherently interdisciplinary field, and so it is. Depending upon which person one selects as making the pioneering contribution to public choice, it came into existence either in the late 18th century as an offshoot of mathematics, or in the late 1940s as an offshoot of economics. The case for the earlier date rests on the existence of publications by two French mathematicians, J.C. de Borda (1781) and M. de Condorcet (1785). Condorcet was the first person, as far as we know, to discover the problem of cycling, the possibility when using the simple majority rule that an alternative x can lose to y in a vote between the two, y can lose to another alternative z, but z will also lose to x. The existence of such a possibility obviously raises the issue of how a community can decide among these three alternatives, when a cycle exists, and what the normative justification for any choice made will be. No cycle exists, of course, if some alternative, say y, can defeat both x and z. The literature has commemorated Condorcet’s contribution by naming such an issue like y a Condorcet winner. A vast number of papers and books have analyzed both the normative and positive implications of the existence of cycles. Condorcet gave his name to one other important part of the public choice literature, when he proved what he called a theorem about juries, and what we now call the Condorcet jury theorem. This remarkable theorem provides both a justification for making collective decisions with the simple majority rule, and for the institution of democracy itself. It rests on three assumptions: (1) The community faces a binary choice between x and y, with only one of the two choices being the ‘‘right’’ choice for the community. (2) Everyone in the community wants to make the right choice. (3) The probability p that a citizen votes for the right choice is greater than 0.5. The theorem states that the probability that the community makes
New insights into roles of intermediate filament phosphorylation and progeria pathogenesis

Intermediate filaments (IFs) form one of the major cytoskeletal systems in the cytoplasm or beneath the nuclear membrane. Because of their insoluble nature, cellular IFs had been considered to be stable for a long time. The discovery that a purified protein kinase phosphorylated a purified IF protein and in turn induced the disassembly of IF structure in vitro led to the novel concept of dynamic IF regulation. Since then, a variety of protein kinases have been identified to phosphorylate IF proteins such as vimentin in a spatiotemporal regulated manner. A series of studies using cultured cells have demonstrated that preventing IF phosphorylation during mitosis inhibits cytokinesis by the retention of an IF bridge‐like structure (IF‐bridge) connecting the two daughter cells. Knock‐in mice expressing phosphodeficient vimentin variants developed binucleation/aneuploidy in lens epithelial cells, which promoted microophthalmia and lens cataract. Therefore, mitotic phosphorylation of vimentin is of great importance in the completion of cytokinesis, the impairment of which promotes chromosomal instability and premature aging. © 2014 IUBMB Life, 66(3):195–200, 2014
Modulation of luminol chemiluminescence of fMet-Leu-Phe-stimulated neutrophils by affecting dephosphorylation and the metabolism of phosphatidic acid.

This paper is addressed to study how PKC-mediated effects and phosphatidic acid interact together in activation of NADPH-oxidase in formyl-methionyl-leucyl-phenylalanine (fMet-Leu-Phe) stimulated neutrophils as detected by luminol chemiluminescence. The early luminescence response in fMet-Leu-Phe-stimulated cells (up to 5 min after stimulation) depends mainly on reactive oxygen species generated extracellularly, whereas all later events are caused by oxidation of luminol inside the cells. The two protein phosphatase inhibitors, okadaic acid and calyculin A, dramatically increased the late luminescence of cells. This enhancement was totally inhibited by the phospholipase D modulator butanol, while the protein kinase C (PKC) inhibitor bisindolylmaleimide I was insensitive. The early luminescence response of the cells was slightly inhibited by both protein phosphatase inhibitors and depended on protein kinase C as well as on phospholipase D activities. Propranolol, an inhibitor of phosphatidate phosphohydrolase, enhanced all parts of luminescence response of fMet-Leu-Phe-stimulated neutrophils at concentrations up to 2.5 x 10(-5) mol/L. While the late luminescence response of propranolol-treated cells was not inhibited by the PKC inhibitor bisindolylmaleimide I, the first response depended on protein kinase C. The inhibitor of diacylglycerol kinase R59949 enhanced the luminescence signal only during the first 4 min in fMet-Leu-Phe-stimulated cells. Only diacylglycerols derived from phospholipase C, such as 1-stearoyl-2-arachidonoyl-sn-glycerol, were able to initiate an oxidative burst in cells. Saturated diacylglycerols (e.g. 1,2-dipalmitoyl-sn-glycerol or 1,2-distearoyl-sn-glycerol) did not yield any luminol chemiluminescence, although they were incorporated into the plasma membrane, as evidenced by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Our results demonstrate that phosphatidic acid produced by phospholipase D is responsible for NADPH-oxidase activity in fMet-Leu-Phe-stimulated neutrophils over the entire measuring time, whereas PKC-mediated processes are only involved during the first 5 min.