Miracle-dz/UniFAR-FTUs huggingface dataset:
Demand Curves for Stocks Slope Down in the Long Run: Evidence from the Chinese Split-Share Structure Reform

The Split-Share Structure Reform in China mandated the conversion of nontradable local A-shares into tradable status and increased A-share float. This paper examines the long-term pricing effects of the increased float. Given that foreign B-shares were not directly affected by this reform, we use B-share price to control for possible changes in firm fundamentals. We find that, across firms, larger increases in A-share float leads to larger decreases in A-share price relative to B-share price, even up to around ten years after the reform, suggesting that demand curves slope down in the long run. We also find that larger increase in float leads to larger decrease in turnover and volatility, and demand curves are less elastic when divergence of opinion is larger, consistent with the theory modelling investors with divergence of opinion.
Platelet Aggregation of Migraineurs During and Between Attacks

Platelet aggregation induced by ADP, collagen and platelet-activating factor was studied in common (migraine without aura) and classical migraine (migraine with aura) patients during and between attacks. The EC 50 * values for ADP and platelet-activating factor were significantly higher, whilst that for collagen was significantly lower in classical migraine patients during headache-free intervals compared to healthy volunteers. The EC50 values obtained for common migraine sufferers during symptom-free periods were similar to those of controls. During attacks, the EC 50 value for ADP, but not for collagen and platelet-activating factor, was significantly higher than that of the controls. In healthy subjects a positive correlation was found between ADP and collagen-induced aggregation. In contrast, there was a U-shaped correlation matrix in classical migraine patients. The present observations show that platelet aggregation is altered in migraine patients and this raises the possibility that platelet-activating factor may be involved in the pathogenesis of migraine.
Trichodiene synthase. Identification of active site residues by site-directed mutagenesis.

Derivatization of 5,5'-dithiobis(2-nitrobenzoic acid)-treated trichodiene synthase with [methyl-14C]methyl methanethiosulfonate and analysis of the derived tryptic peptides suggested the presence of two cysteine residues at the active site. The corresponding C146A and C190A mutants were constructed by site-directed mutagenesis. The C190A mutant displayed partial but significantly reduced activity, with a reduction in kcat/Km of 3000 compared to the wild-type trichodiene synthase, while the C146A mutant was essentially inactive. A hybrid trichodiene synthase, constructed from amino acids 1-309 of the Fusarium sporotrichioides enzyme and amino acids 310-383 of the Gibberella pulicaris cyclase, had steady state kinetic parameters nearly identical to those of the wild-type F. sporotrichioides enzyme. From this parent hybrid, a series of mutants was constructed by site-directed mutagenesis in which the amino acids in the base-rich region, 302-306 (DRRYR), were systematically modified. Three of these mutants were overexpressed and purified to homogeneity. The importance of Arg304 for catalysis was established by the observation that the R304K mutant showed a more than 25-fold increase in Km, as well as a 200-fold reduction in kcat. In addition, analysis of the incubation products of the R304K mutant by gas chromatography-mass spectrometry (GC-MS) indicated that farnesyl diphosphate was converted not only to trichodiene but to at least two additional C15H24 hydrocarbons, mle 204. Replacement of the Tyr305 residue of trichodiene synthase with Phe had little effect on kcat, while increasing the Km by a factor of ca. 7-8. (ABSTRACT TRUNCATED AT 250 WORDS)
The President and the Public: Inaugural Addresses in American History

This article examines presidential inaugural addresses to gain a perspective on the changing relationship between the people and the presidency throughout American political history. The analysis suggests three distinct models of inaugural address—constitutional, party, and plebiscitary—each articulating a different understanding of presidential leadership and the relationship between the presidency and the people. The constitutional presidents see themselves largely as restrained, constitutional officers with a minimal relationship to the people. The party model yields a role for the president which is more tied to the people's will, especially as expressed through party. Even though tied more strongly to the public, party presidents recognize constitutional limits on their roles and powers. Plebiscitary presidents often eschew party affiliation and the guise of constrained constitutional officer, and cast themselves as engines of the American political system fully tied to public opinion. Plebiscitary presidents often make few references to other political actors or to the Constitution. Beyond helping us to better understand the contours of American political development, this analysis challenges the prevalent assumption in studies of the presidency that nineteenth-century presidents were not popular or “public” leaders.
Cell cycle control as a promising target in melanoma

Purpose of review This review highlights recent clinical developments in the therapeutic targeting of cell cycle control in melanoma with cyclin-dependent kinase inhibitors, checkpoint kinases, MDM2, MDM4 and p53 inhibitors. Recent findings The high prevalence of activating genetic aberrations along the p16INK4A:cyclinD-CDK4/6:RB pathway in melanoma and increasing evidence that alterations in this pathway are linked to melanomagenesis, make targeting the p16INK4A:cyclinD-CDK4/6:RB pathway in melanoma logical and highly attractive. The presence of elevated CDK4 activity appears to correlate with greater CDK4/6 inhibitor therapeutic activity, whereas the loss of RB1 has been linked to CDK inhibitor resistance. Other novel compounds targeting cell cycle control via reactivating wild-type p53 and checkpoint kinases are also currently under investigation in melanoma. Summary Cell cycle control is a promising target in the management of melanoma with early data reporting therapeutic benefit with cyclin-dependent kinase inhibitors, MDM2, and p53 reactivation compounds. Many of these drugs have entered phase I and II clinical trial development. Preliminary data from these studies are discussed in this review along with future treatment strategies for maximizing treatment outcomes in advanced melanoma. Video abstract http://links.lww. com/COON/A12
Competitive pressure and managerial decisions

Purpose This study aims to examine the impact of product market competition (PMC) from existing rivals and potential market entrants on earnings quality (EQ) in China. Design/methodology/approach This study examines the impact of PMC on EQ by using the EQ measure of Kothari et al. (2005), and it uses measures for competition from existing and potential rivals. This study analyzed Chinese firms for the period of 2000-2014 and also examined the impact of International Financial Reporting Standards (IFRS) adoption and state ownership on the relationship between PMC and EQ. Findings This study found a positive relationship between PMC and EQ. It also documents that competition from existing rivals does not improve EQ by reducing real activity manipulation, but competition from potential entrants does. The findings propose that market competition from existing rivals is a relevant factor for determining EQ before and after IFRS adoption, but competition from potential entrants improves EQ only after IFRS adoption. Moreover, the results suggest that market competition plays no role in improving the EQ of state-owned enterprises (SOEs). Originality/value The results support the argument that PMC acts as a governance mechanism and influences managerial decisions regarding financial reporting. Our study also helps to understand the impact of change in the regulatory regime, i.e. IFRS adoption, on the relationship between PMC and EQ. This study also helps demonstrate the impact of competition on management decisions with respect to the EQ of SOEs.
Developmental Surface Dyslexia and Dysgraphia: An Orthographic Processing Impairment

This study presents a detailed investigation of a young man in his early twenties who has suffered from a severe spelling impairment since childhood, and currently has a spelling age of only 9 years and 2 months. In contrast with the developmental phonological dyslexics reported by Campbell and Butterworth (1985) and Funnell and Davison (1989), his performance on tests of phonological awareness is good. In addition, he can read and spell non-words competently and, unlike normal 9-year-old children, virtually all of his spelling errors are phonologically appropriate. Further analysis of these errors reveals that he has knowledge of many of the different ways in which a given phoneme can be written, and that he uses phoneme-to-grapheme correspondences at the end of a word that are different from those he uses earlier in a word. However, he finds it difficult to spell words that contain uncommon phoneme-to-grapheme correspondences, which is compatible with the view that he has not developed an orthographic spelling lexicon. Although his oral reading of words is prompt and generally accurate, analysis of his lexical decision performance and the way that he defines homophones indicate that he does not have fully specified lexical entries available for reading either. We suggest that he suffers from a general orthographic processing deficit, and relies instead upon the combination of sub-lexical phonology and a lexicon that contains only partial information about way in which words are spelt. This leads to reasonably competent reading, even of many irregular words, but produces very poor spelling. It is argued that qualitatively different types of developmental dyslexia do genuinely exist, but that reading impairments are likely to be much more pronounced in children who have a phonological rather than an orthographic processing deficit.
Human Immunodeficiency Virus-Specific CD8+ T Cells in Human Breast Milk

ABSTRACT Breast-feeding infants of human immunodeficiency virus (HIV)-infected women ingest large amounts of HIV, but most escape infection. While the factors affecting transmission risk are poorly understood, HIV-specific cytotoxic T-lymphocyte (CTL) responses play a critical role in controlling HIV levels in blood. We therefore investigated the ability of breast milk cells (BMC) from HIV-infected women from the United States and Zambia to respond to HIV-1 peptides in a gamma interferon enzyme-linked immunospot assay. All (n = 11) HIV-infected women had responses to pools of Gag peptide (range, 105 to 1,400 spot-forming cells/million; mean = 718), 8 of 11 reacted to Pol, 7 reacted to Nef, and 2 of 5 reacted to Env. Conversely, of four HIV-negative women, none responded to any of the tested HIV peptide pools. Depletion and tetramer staining studies demonstrated that CD8+ T cells mediated these responses, and a chromium-release assay showed that these BMC were capable of lysing target cells in an HIV-specific manner. These data demonstrate the presence of HIV-specific major histocompatibility complex class I-restricted CD8+ CTLs in breast milk. Their presence suggests a role in limiting transmission and provides a rationale for vaccine strategies to enhance these responses.
Effects of Treatment Intensity in Upper Limb Robot-Assisted Therapy for Chronic Stroke

Background and Objectives. Robot-assisted therapy (RT) is a current promising intervention in stroke rehabilitation, but more research is warranted for examining its efficacy and the dose–benefit relation. The authors investigated the effects of higher intensity versus lower intensity RT on movements of forearm pronation–supination and wrist flexion–extension relative to conventional rehabilitation (CR) in patients poststroke for a mean of 21 months. Methods. In this pilot study, 18 patients with initial mean Fugl-Meyer Assessment (FMA) of 37 to 44 for the upper extremity were randomized to higher intensity RT, lower intensity RT, or CR intervention for 4 weeks. The dose of the higher intensity RT was twice the number of repetitions in the lower intensity RT. Outcome measures at pretreatment and posttreatment were administered to patients to evaluate beneficial and adverse effects of interventions. Primary outcomes were the FMA and Medical Research Council scale. Results. There were significant differences in motor function (P = .04) and daily performance (P = .03) among the 3 groups. The higher intensity RT group showed better improvement in motor function, muscle strength, performance of daily activities, and bimanual ability than the other 2 groups. The intensive RT intervention did not induce higher levels of an oxidative DNA biomarker. Conclusions. Higher intensity of RT that assists forearm and wrist movements may lead to greater improvement in motor ability and functional performance in stroke patients. A sample size of only 20 to 25 in each arm of a larger randomized controlled trial is needed to confirm the findings for similar subjects.
Women\'s Retirement Income Satisfaction and Saving Behaviors

Retirement saving research frequently has investigated the differences between working men and working women and primarily focused on the near retirement and retirement years. There is limited research targeting young to old working-age women including those who do not work for pay and are unemployed. The purpose of this study was to examine what factors affect non-retired working-age (25 years and older) women’s retirement saving behaviors, retirement savings, and retirement income satisfaction. To implement the study, a research framework was developed based on Deacon and Firebaugh’s Family Resource Management Model. The research framework for this study consisted of three major sections: (a) input (demographics, saving motives, retirement saving involvement level, retirement information seeking, current financial assets and debts, and future expectations), (b) throughput (retirement saving behaviors such as calculating needed retirement savings, being a retirement saver, starting saving for retirement age, and being a regular retirement saver), and (c) output (the objective retirement savings and the subjective retirement income satisfaction). An online survey instrument was developed to obtain data for the study. Two pilot tests were conducted to confirm the validity and reliability of the instrument. Data for this study were collected from a national population between May 25, 2012 and May 30, 2012 with 591 valid responses. Several statistical methods were employed: descriptive statistics, one-way between-groups analysis of variance (ANOVA), direct logistic regression, and standard multiple regression.
Regression equations for peak expiratory flow in healthy children aged 7 to 14 years from Punjab, India

Background: Measurement of peak expiratory flow (PEF) is imperative for management and evaluation of asthmatic children. It is well-known that lung function parameters show wide variations with respect to regional, racial, and genetic factors. Aim: This study was conducted to measure PEF in healthy Punjabi children aged 7-14 years as only a few studies have evaluated the lung functions in North Indian children. Materials and Methods: A cross-sectional study was conducted in which PEF was measured in 366 healthy schoolchildren (186 boys and 180 girls) of Patiala district, using the Mini Wright Peak Flow Meter. Best of the three trials was recorded. All the subjects were tested in standing position after recording their age, height, and weight. SPSS v. 13 was used for the statistical analysis. Results: The present study showed that all the three independent variables (age, height, and weight) had a significant positive correlation with PEF, in both genders. Furthermore, height was maximally correlated with PEF in both boys (r = 0.970) and girls (r = 0.964). The mean PEF value in boys (249.34 ± 81.36 L/min) was significantly higher than girls (233.31 ± 67.06 L/min). Regression equations for PEF were also determined using age, height, and weight, separately for the genders. Conclusion: Equations derived from this study for estimation of expected PEF values would help the clinicians in assessing the airway obstruction in this population subset.
Impaired glucose tolerance during pregnancy is associated with increased fetal mortality in preceding sibs

Objectives, To analyze whether women with a diagnosis of gestational diabetes in the current pregnancy had an increased rate of stillbirths or of large for gestational age infants in previous pregnancies without an overtly present/diagnosed gestational diabetes. Design. A case‐control analysis with two controls for each case, matched for year of delivery, maternal age (5 year class), and parity. Material ami methods. All women with a diagnosis of gestational diabetes and delivered between 1987 and 1992 were identified from the Swedish Medical Birth Registry. For each woman, the first delivery with that diagnosis was used as proband case (n = 3,958). To each case and control, all previous sibs since 1973 were identified. Comparisons were made between cases and controls but also between sibs of cases and sibs of controls. Results. No significant difference was found in stillbirth rate between cases and controls (OR 1.33. CL 0.64: 2.77). The rate of intrauterine deaths was significantly increased among previous sibs of the cases compared with the sibs of the controls: after stratification for year of birth, maternal age and parity an odds ratio of 1.56 (95% CL 1.12;2.19) was found. Infants born of women with gestational diabetes were heavier (mean 145 g, 95% CL 123; 168 g). Similar differences were seen between immediately previous sibs of cases and controls (mean 155g. 95% CL 127: 183 g). Conclusions. The figures indicate that in pregnancies before a delivery with gestational diabetes the perinatal prognosis was significantly poorer than expected which could be due to the presence of undiagnosed and untreated gestational diabetes. The results argue for an improved screening for gestational diabetes during pregnancy.
Network Quantile Autoregression

It is a challenging task to understand the complex dependency structures in an ultra-high dimensional network, especially when one concentrates on the tail dependency. To tackle this problem, we consider a network quantile autoregres- sion model (NQAR) to characterize the dynamic quantile behavior in a complex system. In particular, we relate responses to its connected nodes and node spe- ci c characteristics in a quantile autoregression process. A minimum contrast estimation approach for the NQAR model is introduced, and the asymptotic properties are studied. Finally, we demonstrate the usage of our model by in- vestigating the nancial contagions in the Chinese stock market accounting for shared ownership of companies.
Disciplinary Differences in Out-of-School High School Science Experiences and Influence on Students’ Engineering Choices

Participation from a variety of students is important to the long-term growth of the engineering field. Much of the research on engineering recruitment or career choice has focused on engineering as a whole, even though engineering disciplines are varied in student participation and focus. This work examines how students’ out-of-school interests and experiences in high school predict the likelihood of choosing a career in a particular engineering discipline. Out-of-school experiences offer more unstructured ways for students to meaningfully engage with science and engineering outside of the confines of the classroom. These experiences offer opportunities to spark particular science interests not included in traditional high school science curriculum. Additionally, participation in engineering for women has been historically low. For this reason, we also examined reported differences in out-of-school experiences by gender. Our findings indicate that reported out-of-school experiences increased the odds of students choosing particular engineering disciplines. Experiences traditionally stereotyped as masculine and more often reported by men, such as tinkering, increased the odds of choosing engineering disciplines with higher representation of men. However, some experiences equally reported by men and women, such as mixing chemicals or engaging with chemistry in the kitchen or talking with friends or family about science, predicted higher odds of choosing engineering disciplines with higher representation of women (chemical, biomedical, environmental). These quantitative results are a first step in understanding how out-of-school experiences are connected to the nuanced decisions of disciplinary engineering career decisions and have implications for the way engineering faculty draw on prior experience in the classrooms and for researchers on how out-of-school activities may predict students’ long-term career decisions.
Decreased immunoreactive beta-endorphin in mononuclear leucocytes from patients with chronic fatigue syndrome.

OBJECTIVE To investigate beta-endorphin concentrations in the peripheral blood mononuclear cells (PBMC) of patients with chronic fatigue syndrome (CFS). METHODS Sixteen patients with CFS were enrolled in this study. Ten healthy subjects were studied as controls. Beta-endorphin concentrations were measured in PBMC by radioimmunoassay performed with antibodies specific for the C-terminal portion of human beta-endorphin. RESULTS Beta-endorphin concentrations in the PBMC of chronic fatigue patients were significantly lower (p < 0.001) than in healthy subjects (mean +/- SD: 8.5 +/- 7.0 vs. 42.6 +/- 22.6). CONCLUSION Patients with CFS were found to have low levels of PBMC beta-endorphin. This finding may reflect the condition of chronic immune activation in CFS that has been reported in previous investigations. Beta-endorphin concentrations in PBMC seem to mirror the central nervous system homeostasis of the opioid. Therefore, we would postulate that the fatigue and weakness typical of CFS could be related to low beta-endorphin concentrations at the central nervous system level.
Efficient and Robust Emergence of Norms through Heuristic Collective Learning

In multiagent systems, social norms serves as an important technique in regulating agents’ behaviors to ensure effective coordination among agents without a centralized controlling mechanism. In such a distributed environment, it is important to investigate how a desirable social norm can be synthesized in a bottom-up manner among agents through repeated local interactions and learning techniques. In this article, we propose two novel learning strategies under the collective learning framework, collective learning EV-l and collective learning EV-g, to efficiently facilitate the emergence of social norms. Extensive simulations results show that both learning strategies can support the emergence of desirable social norms more efficiently and be applicable in a wider range of multiagent interaction scenarios compared with previous work. The influence of different topologies is investigated, which shows that the performance of all strategies is robust across different network topologies. The influences of a number of key factors (neighborhood size, actions space, population size, fixed agents and isolated subpopulations) on norm emergence performance are investigated as well.