Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of Toll Like Receptors 3 & 7 in Peripheral Blood from Patients with Chronic Hepatitis C Virus Infection and Their Correlation with Interferon-α 1

Toll-like receptor 3 (TLR3) and Toll-like receptor 7 (TLR7) are pathogenrecognition receptors that are expressed on innate immune cells. They recognize viral RNA which induces their activation with subsequent increase in IFN-α transcription. It has been postulated that HCV may cause down regulation of these receptors as one of immune evading mechanisms that participate in viral persistence. The aim of this work is to investigate the expression of Toll-like receptors 3 (TLR3) and 7 (TLR7) in peripheral blood from patients with chronic hepatitis C infection and correlate their expression to the peripheral blood expression of interferon-α (IFN-α), viral load and histopathology of the liver. IFN-α, TLR3 and TLR7 expression in peripheral blood from patients with chronic hepatitis C infection (n= 30) and from healthy controls (n= 20) were measured by real time polymerase chain reaction. Viral load and Liver biopsy were done for all patients. The results showed lower expression of TLR3 and TLR7 in patients than controls, and levels of expression correlated positively with IFN-α expression. No correlation was found between TLR3 and TLR7 and viral load or histopathological staging and grading of the liver tissue. In conclusion, HCV may induce down regulation of TLRs (TLR3 and TLR7) expression on innate immune cells with subsequent decrease in INFα production suggesting that new therapies that aim to increase the expression level of TLRs may help in treatment of HCV infection.
Spinal anaesthesia for cesarean section with reduced dose of intrathecal bupivacaine plus fentanyl.

BACKGROUND AND OBJECTIVES The hypotension following spinal anesthesia remains common place in cesarean delivery. The combination of reduced dose of local anesthetics with intrathecal opioids makes it possible to achieve adequate spinal anesthesia with minimum hypotension. We investigate whether this synergistic phenomenon could be used to provide less frequent hypotension while incurring adequate spinal anesthesia for cesarean section. METHODS Forty women scheduled for cesarean delivery (twenty in each group) were divided into two groups of patients who received a spinal injection of either 13.5 mg of standardized isobaric 0.5% bupivacaine or 9 mg of isobaric bupivacaine with 20 microgr fentanyl added. Each measurement of a systolic blood pressure less than 95 mm Hg or a decrease in systolic pressure of greater than 25% from baseline was considered as hypotension and treated with a bolus of 5 to 10 mg of intravenous ephedrine. The quality of surgical anesthesia was evaluated also. RESULTS Spinal block provided excellent surgical anesthesia in almost all patients. Peak sensory level was higher (Th 2-3 vs. Th 4-5) and motor block was more intense in the plain bupivacaine group; the patients from standardized bupivacaine group were more likely to require treatment for hypotension (75% vs 15%) and had more persistent hypotension (4.6 vs. 1.0 hypotensive measurements per patient) than patients in the reduced bupivacaine-fentanyl group. Mean ephedrine requirements were 22.0 mg and 3.5 mg, respectively. Patients in the bupivacaine group also complained of emetic effects more frequently than patients in the reduced dose bupivacaine-fentanyl group. CONCLUSIONS Bupivacaine 9 mg plus fentanyl 20 microgr provided spinal anesthesia for cesarean delivery with less hypotension and vasopressor requirements while ensuring excellent perioperative surgical anesthesia.
Comparison and application of different VHDL-based fault injection techniques

Compares different VHDL-based fault injection techniques: simulator commands, saboteurs and mutants for the validation of fault tolerant systems. Some extensions and implementation designs of these techniques have been introduced. Also, a wide set of non-usual fault models have been implemented. As an application, a fault tolerant microcomputer system has been validated. Faults have been injected using an injection tool developed by the GSTF. We have injected both transient and permanent faults on the system model, using two different workloads. We have studied the pathology of the propagated errors, measured their latencies, and calculated both detection and recovery coverages. Preliminary results show that coverages for transient faults can be obtained quite accurately with any of the three techniques. This enables the use of different abstraction level models for the same system. We have also verified significant differences in implementation and simulation cost between the studied injection techniques.
ANALISIS IMPLEMENTASI TRANSAKSI NON TUNAI (NON CASH) DALAM MEWUJUDKAN GOOD GOVERNANCE PADA PEMERINTAH KOTA YOGYAKARTA

Penelitian ini dilakukan untuk mengetahui bagaimana prosedur pembayaran secara non tunai yang dilakukan Pemerintah Daerah wilayah Kota Yogyakarta, pelaporan bendahara/pencatatan yang dilakukan oleh bendahara saat terjadinya pembayaran secara non tunai, dan melihat apakah pelaksanaan transaksi non tunai (Non Cash) mampu mewujudkan good governance dalam tata kelola keuangan Pemerintah Kota Yogyakarta, yaitu Akuntabilitas, Transparan, Efektif, dan Efisien. Penelitian ini dilakukan pada Badan Pengelolaan Keuangan dan Aset Daerah Pemerintah Kota Yogyakarta. Prosedur pelaksanaan pembayaran non tunai pada Pemerintah Kota Yogyakarta belum mencapai 100 persen, karena transaksi dibawah Rp. 500.000,- masih menggunakan pembayaran tunai. Implementasi non tunai dapat mewujudkan good governance yaitu akuntabilitas, transparasi, efektif dan efesien dalam pengelolaan keuangan daerah karena setelah adanya pembayaran non tunai semua transaksi tercatat secara real, pembayaran dapat dilakukan secara cepat dan tepat tanpa harus melalui perantara, pembukuan juga dapat disajikan secara akurat dan tepat waktu.
Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5‐FU‐based neo‐adjuvant chemoradiotherapy in rectal cancer

Pre‐operative 5‐fluorouracil (5‐FU)‐based chemoradiotherapy in locally advanced rectal cancer (UICC‐II/III) may significantly reduce local tumour mass. Response to pre‐operative treatment, however, varies significantly. Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidine dehydrogenase (DPD) are thought to be important predictors for the efficiency of 5‐FU‐based treatment. The aim of this study was to determine the correlation between TS‐, TP‐, and DPD‐gene expression and the response to 5‐FU‐based long‐term pre‐operative chemoradiotherapy assessed by histopathological tumour regression. Additionally, the predictive value of intra‐tumoural TS‐, TP‐, and DPD‐gene expression in pre‐operative rectal tumour biopsies was assessed by correlation with the histopathological regression grade. Formalin‐fixed, paraffin wax‐embedded pre‐operative biopsies (n = 14) and surgical resection specimens (n = 40) from patients with rectal carcinoma (clinical UICC stage II/III) receiving neo‐adjuvant 5‐FU‐based chemoradiotherapy were studied for TS‐, TP‐, and DPD‐gene expression by quantitative TaqMan real‐time PCR after laser microdissection. Results were compared with standardized histopathological tumour regression analysis. There was a significant association between low TS‐gene expression in pre‐operative tumour biopsies and tumour response (p = 0.02). TS‐ and TP‐gene expression was significantly lower in resection specimens of responders than of non‐responders (p = 0.02) when microdissection was used. Statistical significance was even higher when TS and TP were combined (p = 0.0001). For the DPD gene, no significance was found at all. In conclusion, this study shows that TS gene expression in a pretreatment biopsy predicts the response of local rectal cancer to neo‐adjuvant 5‐FU‐based chemoradiotherapy in a high percentage. Moreover, intra‐tumoural TS‐ and TP‐gene expression in surgical rectal specimens after neo‐adjuvant chemoradiotherapy correlates significantly with histopathological tumour regression when microdissection is applied. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
of same and different in matchand matchand matchand nonmatch nonmatch nonmatch

http://dx.doi. org/10.1016/j.cogpsych. 2016.01. 005 0010-0285/ 2016 Elsevier Inc. All rights reserved. ⇑ Corresponding author at: CNRS – Institut des Sciences Cognitives – Marc Jeannerod – UMR 5304 (Laboratoire sur le le Cerveau et la Cognition – L2C2), Univ Lyon, 67 Boulevard Pinel, 69675 Bron, France. E-mail address: jr.hochmann@gmail.com (J.-R. Hochmann). Jean-Rémy Hochmann a,b,⇑, Shilpa Mody , Susan Carey a
SmvA, and not AcrB, is the major efflux pump for acriflavine and related compounds in Salmonella enterica serovar Typhimurium.

OBJECTIVES The aim was to study the role played by SmvA pump in the efflux of quaternary ammonium compounds (QACs) in Salmonella enterica serovar Typhimurium (Salmonella Typhimurium). METHODS Mutants in the smvA, acrB and tolC genes were constructed by the red swap method. P22 was used to transduce tolC to acrB and smvA mutant strains. The susceptibility of these strains to acriflavine and a variety of QACs was determined by MIC assays. RESULTS In comparison with the Salmonella Typhimurium wild-type strain, the smvA mutant was more susceptible to QACs than the acrB mutant strain. A tolC single mutant was more susceptible than an acrB mutant to QACs, acriflavine, ethidium bromide, malachite green and pyronin B. The tolC-acrB double mutant was as susceptible as the single tolC mutant to QACs. Additionally, the smvA mutant strain was more susceptible to acriflavine than the acrB mutant (MICs = 31.3 versus 125 mg/L, i.e. 4-fold). Finally, the tolC-smvA double mutant (3.9 mg/L) was approximately 10 times more susceptible to acriflavine than either smvA (31.3 mg/L) or tolC (31.3 mg/L) single mutants. CONCLUSIONS It is the SmvA efflux pump, and not AcrB, that plays the major role in the efflux of acriflavine and other QACs from Salmonella Typhimurium. This apparently conflicting report is due to the fact that in Escherichia coli the smvA gene does not exist. Our results suggest that tolC and smvA genes encode components of two different efflux systems with overlapping specificities that work in parallel to export acriflavine and other QACs.
The Effect of Knowledge Management on Empowerment of Youth and Sports General Directorate of Mazandaranprovince

The purpose of this study was to investigate the effect of knowledge management on the empowerment of employees of the Ministry of Sport and Youth in Mazandaran province. The research method was field survey and has been done on field based. The statistical population of this study is all employees of the Ministry of Sports and Youth of Mazandaran province, which were selected using the Morgan table in 129 simple random samples. The knowledge empowerment and management questionnaire was used to collect information. Regarding the analysis and analysis of the multivariate regression test, the SPSS23 software was used. The findings of the research showed that there is a positive and significant relationship between the components of knowledge management and empowerment and knowledge management has an impact on empowerment of employees.
Pulmonary Capillaritis as a Manifestation of Acute Humoral Allograft Rejection Following Infant Lung Transplantation

Pulmonary capillaritis has been described in adult lung transplant recipients, but has not been previously reported in pediatric recipients. We report a case of posttransplant pulmonary capillaritis in an 8‐month‐old infant, and demonstrate evidence of C4d deposition and B‐lymphocytes in the allograft, donor anti‐HLA antibodies in the serum and a clinical and immunohistochemical response to anti‐CD20 monoclonal antibody (rituximab) therapy. These findings strongly support the hypothesis that pulmonary capillaritis may represent a form of acute humoral rejection in the lung allograft that is less common than, and clinically and histologically distinct from, typical acute cellular rejection.
High prevalence of erectile dysfunction in diabetes: a systematic review and meta‐analysis of 145 studies

Erectile dysfunction may be common among men with diabetes, but its prevalence is still debated. We aimed to assess the relative prevalence of erectile dysfunction in diabetes searching major databases from inception to November 2016 for studies reporting erectile dysfunction in men with Type 1 and Type 2 diabetes mellitus. We conducted a meta‐analysis of the prevalence [and 95% confidence intervals (95% CIs)] of erectile dysfunction in diabetes compared with healthy controls, calculating the relative odds ratios (ORs) and 95% CIs. A random effect model was applied. From 3747 initial hits, 145 studies were included representing 88 577 men (age: 55.8 ± 7.9 years). The prevalence of erectile dysfunction in diabetes overall was 52.5% (95% CI, 48.8 to 56.2) after adjusting for publication bias, and 37.5%, 66.3% and 57.7% in Type 1, Type 2 and both types of diabetes, respectively (P for interaction < 0.0001). The prevalence of erectile dysfunction was highest in studies using the Sexual Health Inventory for Men (82.2%, 17 studies, P for interaction < 0.0001). Studies with a higher percentage of people with hypertension moderated our results (beta = 0.03; 95% CI, 0.008 to 0.040; P = 0.003; R2 = 0.00). Compared to healthy controls (n = 5385) men with diabetes (n = 863) were at increased odds of having erectile dysfunction (OR 3.62; 95% CI, 2.53 to 5.16; P < 0.0001; I2 = 67%, k = 8). Erectile dysfunction is common in diabetes, affecting more than half of men with the condition and with a prevalence odds of approximately 3.5 times more than controls. Our findings suggest that screening and appropriate intervention for men with erectile dysfunction is warranted.
Importance-Performance Matrix Analysis (IPMA) of Service Quality and Customer Satisfaction in the Ghanaian Banking Industry

Drawing from the Importance-Performance Matrix Analysis (IPMA), this paper sought to examine service quality and customer satisfaction in the Ghanaian banking industry. A quantitative approach using questionnaires was adapted to survey 476 bank customers for the study. Data were analysed using structural equation model (SEM) - Partial Least Square (PLS). We found that except tangibility, the remaining four service quality dimensions - reliability, assurance, empathy, and responsiveness - have a significant influence on customer satisfaction. Meanwhile, the Importance Performance Matrix Analysis (IPMA) identified service reliability as the most important service quality dimension valued by customers but the highest service performance belongs to service tangibility. Performing well on tangibility dimension instead, the findings indicate a mismatch between customers’ interests and banks’ efforts. We recommend that the banks give the highest priority to service reliability and responsiveness by shifting their resource allocation focus from service tangibility, which appeared to be the least relevant service quality dimension from their customers’ perspective. The study contributes to the development and relevance of service quality dimensions towards improving banks’ service quality delivery practices in emerging economies.
Oral Health Status and Treatment Needs of Lock Factory Workers in Aligarh City

Introduction: Oral health is a vital part of general health and is a valuable asset of every individual. It is an important public health problem owing to the prevalence, socio-economical aspect, expensive treatment, and lack of awareness. The health of industrial workers often goes uncared due to their stressful working conditions, busy schedules, and poor economic conditions. Aims and Objective: The aim was to assess the oral health status and treatment needs of lock factory workers in Aligarh city. Materials and Methods: A cross-sectional study was conducted among 850 lock factory workers (19-64 years) in Aligarh city. A clinical examination for recording the oral health status was based on WHO Basic Oral Health Assessment (2013). Descriptive analysis was done and the data were analyzed by using Chi-square test, fisher’s exact test, and ANOVA test. P ≤ 0.05 was considered to be statistically significant. Results: The prevalence of dental caries in the workers was found to be 46.9%. The mean dentition status of factory workers was found to be 5.16 ± 5.15. Total 72.1% workers had gingival bleeding, 42 (4.9%) had questionable form of enamel fluorosis, and 184 (21.6%) factory workers were having dental erosion. The oral mucosal lesions prevalence was 20.8% and it was found that most common site for oral mucosal lesions was buccal mucosa. 18% had traumatic teeth and only 9% factory workers had partial dentures. Conclusion: The results of the study showed that periodontal diseases, mucosal lesions, and dental caries are major public health problems among the factory workers. Primary oral health care programs like dental screening and oral health education at regular intervals should be made mandatory which will help to prevent accumulation of health care demands of the factory employees.
The Impact of Nanoscience on Heterogeneous Catalysis

Most catalysts consist of nanometer-sized particles dispersed on a high-surface-area support. Advances in characterization methods have led to a molecular-level understanding of the relationships between nanoparticle properties and catalytic performance. Together with novel approaches to nanoparticle synthesis, this knowledge is contributing to the design and development of new catalysts.
Measurement of organ blood flow using tritiated water. II. Uterine blood flow in conscious pregnant ewes.

Total uterine blood flow was measured with a tritiated water (TOH) diffusion method and with radioactive microspheres in six, conscious, pregnant ewes. With continuous infusion of TOH, equilibrium between the TOH concentration in utero-ovarian venous blood and arterial blood was attained within 50 min of the start of the infusion. The concentration of TOH in uterine and foetal tissue and in foetal blood water was the same as that in uterine venous water by 40 min; at this time, the concentration of TOH in the water of amniotic and allantoic fluids was 96% of that in uterine venous blood water. Estimates of total uterine blood flow obtained using TOH were highly correlated with those obtained with microspheres (r = 0.889, P less than 0.001, n = 8) and the corresponding mean (+/- s.e.m.) flow values obtained with the two techniques (1030.5 +/- 110.6 and 1006.2 +/- 100.0 ml min-1, respectively) did not significantly differ. The percentage of the total uterine blood flow passing through arteriovenous anastomoses ranged from 1.4 to 3.3%.
No Sorting, No Advantage: Regression Discontinuity Estimates of Incumbency Advantage in Japan

While the existing literature has identified a sizable incumbency advantage in single-member district (SMD) races in developed democracies, we argue that some political and institutional contexts of Japan's Lower House elections would undermine the incumbency advantage. Our regression discontinuity (RD) analysis indeed shows little advantage, and further examination suggests this as largely due to the “best-loser” provision in Japan's mixed-member system, which gives a loser of SMD competition a chance to be a “resurrected” incumbent. We also show no evidence of sorting – i.e., systematic difference between bare winners and bare losers – in close SMD races and thus add further evidence to support the methodological argument that the election RD analysis is a viable and promising research design.
Association of Mitogen-Activated Protein Kinase Pathways with Gingival Epithelial Cell Responses to Porphyromonas gingivalis Infection

ABSTRACT Mitogen-activated protein (MAP) kinase pathways are key factors in host signaling events and can also play important roles in the internalization of pathogenic bacteria by host cells.Porphyromonas gingivalis, a periodontal pathogen, can efficiently invade human gingival epithelial cells (GECs). In this study, we examined the activation of MAP kinase pathways in GECs infected with P. gingivalis. c-Jun N-terminal kinase (JNK) was activated after 5 min of infection with P. gingivalis, whereas noninvasiveStreptococcus gordonii did not have a significant effect on JNK activation. In contrast, extracellular signal-regulated kinase (ERK) 1/2 was downregulated in a dose-dependent manner by P. gingivalis, but not by S. gordonii, after a 15-min exposure. Nonmetabolically active P. gingivaliscells were unable to modulate MAP kinase activity. U0126, a specific inhibitor of MEK1/2 (ERK1/2 kinase), and toxin B, a specific inhibitor of Rho family GTPases, had no effect on P. gingivalis invasion. Genistein, a tyrosine protein kinase inhibitor, blocked uptake of P. gingivalis. The transcriptional regulator NF-κB was not activated by P. gingivalis. These results suggest that P. gingivalis can selectively target components of the MAP kinase pathways. ERK1/2, while not involved in P. gingivalisinvasion of GECs, may be downregulated by internalized P. gingivalis. Activation of JNK is associated with the invasive process of P. gingivalis.
Impact of Slope on Productivity of a Self-levelling Processor

Slope is a major factor affecting forest harvesting machine productivity. As ground-based harvesting methods are generally cheaper than the alternatives, forest managers need to know when ground-based harvesting equipment can be used on sloping sites. The study objective was to determine the effect of slope on the productivity, cycle time and elemental times of a Valmet 450 FXL self-levelling processor processing a 24 year-old, un- thinned radiata pine plantation previously felled and stacked by a feller-buncher. The study site slope was estimated using a LiDAR (Light Detection and Ranging) derived digital terrain model and classified using the regional terrain classification system. Study trees were selected from areas predominantly in the hilly (12-19°) and steep (20-26°) slope classes, as these classes made up the majority of the study site area. In contrast to previous research, no significant differences were found between the processor productivity, cycle time and elemental times (moving/positioning, swinging and processing) between the slope classes. This was believed to result from the processor working well within its capabilities processing the relatively small trees on the study site. Other important factors may have included that the trees were pre-felled by a feller-buncher and placed in high den- sity rows with their butt ends aligned, which minimised the processor boom and track move - ments, and that steep slope trees were selected from areas at the lower end of the steep slope class (20-23°). Further research is needed to determine whether the processor productivity would be significantly lower when processing larger trees on steeper slopes.