Miracle-dz/UniFAR-FTUs huggingface dataset:
Automatic processing of fundamental information: the case of frequency of occurrence.

One view of memory supposes that several fundamental aspects of experience are stored in memory by an implicit or automatic encoding process. In this article we review the evidence that suggests that information about frequency of occur- rence is encoded in such a manner. This evidence shows that frequency information is stored for a wide variety of naturally occurring events. Laboratory research shows that usually powerful task variables (for example, instructions, practice) and subject vari- ables (for example, age, ability) do not influence the encoding process. Evidence is also reviewed that either directly or indirectly implicates the use of frequency information across issues in psychology ranging from the acquisition and representation of knowledge domains to decision making to sex role development.
Expected Spot Prices and the Dynamics of Commodity Risk Premia

We analyse a novel time series of investors’ expectations on future commodity spot prices, and show that a model with adaptive learning can replicate investors' forecasts. We use this framework to back out the dynamics of the (ex-ante) risk premia for different commodities and maturities, and provide evidence that commodity risk premia are time-varying and their dynamics is predominantly due to the changing nature of risk sharing and appetite, as proxied by open interest, hedging pressure and time-series momentum. Finally, we show that the explanatory power of alternative factors is not constant over time, both across commodities and time horizons.
Effect of Presurgical Iodine-Based Disinfection on Bacterial Colonization of the Equine Peripodal Region.

OBJECTIVE To compare bacterial colonization after diluted iodine tincture or povidone iodine solution for presurgical disinfection of the equine peripodal region. STUDY DESIGN Complete block design. ANIMALS Five horses. METHODS Disinfection protocols using iodine tincture or povidone iodine solutions were tested on 5 pairs (n = 10) equine front feet. Iodine tincture was applied to the left feet and povidone iodine to the right feet. Fixed surfaces of the sole, frog, hoof wall, and peripodal skin were swabbed pre-preparation (T0), after a standard pre-disinfection step (T1), after short disinfection with a 4-minute application of 0.5% iodine tincture or povidone iodine (T2), and after long disinfection with 12-hour soaking in 0.25% iodine tincture or povidone iodine (T3). Quantitative bacteriology was performed on each swab. RESULTS The frog and sole were the most contaminated sites compared to hoof wall and skin at T0. Bacterial counts were significantly decreased at T2 for both solutions. Bacterial counts did not change significantly with iodine tincture at T3 but increased with povidone iodine compared to T2. Skin abrasions were detected on almost all feet but were subjectively more severe on iodine tincture-treated feet. CONCLUSION Soaking for 12 hours with either iodine tincture or povidone iodine is not recommended as these solutions damaged the skin and bacterial recolonization was noted with povidone iodine. Four-minute disinfection using either iodine tincture or povidone iodine (0.5% available iodine) is appropriate for presurgical preparation of the equine peripodal region.
Comparative Neuroprotective Properties of Stilbene and Catechin Analogs: Action Via a Plasma Membrane Receptor Site?

Various studies have reported on the neuroprotective effects of polyphenols, widely present in food, beverages, and natural products. For example, we have shown that resveratrol, a polyphenol enriched in red wine and other foods such as peanuts, protects hippocampal cells against β‐amyloid (Aβ)‐induced toxicity, a key protein involved in the neuropathology of Alzheimer disease. This effect involves, at least in part, the capacity of resveratrol to activate the phosphorylation of delta isoform of protein kinase C (PKC‐δ). The neuroprotective action of resveratrol is shared by piceatannol, a stilbene derivative, as well as by tea‐derived catechin gallate esters. The thioflavin T assay indicated that all these polyphenols inhibited the formation of Aβ fibrils, suggesting that this action likely also contributes to their neuroprotective effects. Binding and autoradiographic studies revealed that the effects of polyphenols might involve specific binding sites that are particularly enriched in the choroid plexus in the rat brain. Interestingly, the choroid plexus secretes transthyretin, a protein that has been shown to modulate Aβ aggregation and that may be critical to the maintenance of normal learning capacities in aging. Taken together, these data suggest that polyphenols target multiple enzymes/proteins, leading to their neuroprotective actions, possibly through action via specific plasma membrane binding sites.
Rheological behavior of litchi juice concentrates during storage

The rheological behavior of litchi juice concentrate prepared from two cultivars viz. cv. Dehradun and cv. Seedless late was studied as a function of storage temperature, storage period and preservative used during storage for six months. The rheological behavior of prepared juice concentrate was studied at temperature range of 20-50°C over the shear rate of 0.6-145.80 s -1 and the data was fitted to power law equation. Consistency index varied between 29.6-1559.7 Pa.s and 18.9-3218.1 Pa.s whereas, the flow behavior index (n) varied between 0.65-0.96 and 0.72-0.97 for cv. Dehradun and cv. Seedless late, respectively. The values of consistency index were found to increase with the increase in storage period and the increase was more prominent for concentrates stored at low temperature for both the varieties. Flow behavior index decreased during storage however, the decrease was slightly higher in juice concentrate prepared from Deharadun variety at the end of storage period. The increase in viscosity was higher in the concentrate stored at low temperature as compared to the samples stored at ambient temperature in both varieties. The activation energy ranged between 29.38-44.27 kJ/mol and 28.88-42.45 kJ/mol for cv. Dehradun and cv. Seedless late, respectively.
Ho:YAG Laser Treatment of Hyperplastic Inferior Nasal Turbinates

Objectives: Although preliminary studies about the successful use of the Ho:YAG laser in nasal turbinate surgery have been reported, no clinical study has been performed on this procedure. The aim of this prospective clinical study was to assess the long‐term effect of Ho:YAG laser in the treatment of hyperplastic inferior nasal turbinates.
Evolutionary Balancing of Fitness‐Limiting Factors

Debates concerning the roles of different factors that may limit an organism’s reproductive success pervade evolutionary ecology. We suggest that a broad class of limiting‐factors problems involving essential resources or essential components of reproductive effort can be analyzed with an evolutionary application of Liebig’s law of the minimum. We explore life‐history evolution using the metaphor of an organism that must harvest two essential resources (resources 1 and 2) from a stochastically varying environment. Our models make three predictions. First, organisms should overinvest, relative to the deterministic case, in harvesting the resource whose per‐offspring harvest cost is smaller. Second, at the optimum, organisms balance multiple fitness‐limiting factors rather than being consistently limited by one factor. Third, the optimal investment in harvesting a resource is directly linked to the probability that the organism’s fitness will be limited by that resource. Under temporal variation, the optimal proportional investment in harvesting resource 1 is equal to the probability that resource 1 will limit fitness. Our results help to explain why the responses of populations to environmental perturbations are hard to predict: as an organism transitions between different limiting factors, its responses to perturbations of those factors will likewise change.
Quantitative Feedback Contribution to Design of Voltage Regulator Modules

This work presents a new design method suitable for voltage regulator modules (VRM) requirements. The new method takes into account system uncertainty and it could be easily adapted to new requirements from the industry. The limitations of voltage and current modes to match the output impedance requirement are derived while the measurement of load current is found to be a valid approach to obtain the required voltage regulation characteristic. Simulation results prove the theoretical analysis and controller design.
Images Perceived After Chromatic or Achromatic Contrast Sensitivity Losses

Purpose. We simulate how subjects with losses in chromatic and achromatic contrast sensitivity perceive colored images by using the spatiochromatic corresponding pair algorithm. Methods. This is a generalized version of the algorithm by Capilla et al. (J Opt Soc Am (A) 2004;21:176–186) for simulating color perception of color deviant subjects, which incorporates a simple spatial vision model, consisting of a linear filtering stage, with a band-pass achromatic filter and two low-pass chromatic ones, for the red-green and blue-yellow mechanisms. These filters, except for the global scaling, are the subject's contrast sensitivity functions measured along the cardinal directions of the color space. In its present form, the algorithm would serve to simulate alterations both in the spectral sensitivities and in the contrast sensitivities of the visual mechanisms. Results. After a preliminary theoretical study on the effect of frequency selective and overall reductions in the contrast sensitivity function of a single mechanism, we present cases of real subjects with glaucoma and diabetes, suffering alterations of different magnitude in the three mechanisms. Conclusions. The simulations allow us to learn about the different types of distortions that can be experienced by a subject with impaired contrast sensitivities (blur, haloes, color shifts, local or global contrast, brightness and colorfulness reductions, etc.) and highlight the difficulties arising when trying to predict the quality of the final image from the losses in the individual mechanisms.
Improved Microsurgical Creation of Venous Pouch Arterial Bifurcation Aneurysms in Rabbits

BACKGROUND AND PURPOSE: The choice of the experimental aneurysm model is essential for valid embolization-device evaluations. So far, the use of the rabbit venous pouch arterial bifurcation aneurysm model has been limited by demanding microsurgery, low aneurysm patency rates, and high mortality. This study aimed to facilitate microsurgery and to reduce mortality by optimized peri-/postoperative management. MATERIALS AND METHODS: Aneurysms were created in 16 New Zealand white rabbits under general intravenous anesthesia. Using modified microsurgical techniques, we sutured a jugular vein pouch into a bifurcation created between both CCAs. Aggressive anticoagulation (intraoperative intravenous: 1000-IU heparin, 10-mg acetylsalicylic acid/kg; postoperative subcutaneous: 14 days, 250-IU/kg /day heparin) and prolonged postoperative anesthesia (fentanyl patches: 12.5 μg/h for 72 hours) were applied. Angiographic characteristics of created experimental aneurysms were assessed. RESULTS: The reduced number of interrupted sutures and aggressive anticoagulation caused no intra-/postoperative bleeding, resulting in 0% mortality. Four weeks postoperation, angiography showed patency in 14 of 16 aneurysms (87.5%) and Ohshima type B bifurcation geometry. Mean values of parent-artery diameters (2.3 mm), aneurysm lengths (7.9 mm), and neck widths (4.1 mm) resulted in a mean 1.9 aspect ratio. CONCLUSIONS: Compared with historical controls, the use of modified microsurgical techniques, aggressive anticoagulation, and anesthesia resulted in higher aneurysm patency rates and lower mortality rates in the venous pouch arterial bifurcation aneurysm model. Gross morphologic features of these aneurysms were similar to those of most human intracranial aneurysms.
Genetic variants of NBS1 predict clinical outcome of platinum-based chemotherapy in advanced non-small cell lung cancer in Chinese.

OBJECTIVE NBS1 plays a key role in the repair of DNA double-strand break (DSB). We conducted this study to investigate the effect of two critical polymorphisms (rs1805794 and rs13312840) in NBS1 on treatment response and prognosis of advanced non-small cell lung cancer (NSCLC) patients with platinum-based chemotherapy. METHODS Using TaqMan methods, we genotyped the two polymorphisms in 147 NSCLC patients. Odds ratios (ORs) and their 95% confidential intervals (CIs) were calculated as a measure of difference in the response rate of platinum-based chemotherapy using logistic regression analysis. The Kaplan-Meier and log-rank tests were used to assess the differences in progression-free survival (PFS) and overall survival (OS). Cox proportional hazards model was applied to assess the hazard ratios (HRs) for PFS and OS. RESULTS Neither of the two polymorphisms was significantly associated with treatment response of platinum-based chemotherapy. However, patients carrying the rs1805794 CC variant genotype had a significantly improved PFS compared to those with GG genotype (16.0 vs. 8.0 months, P = 0.040). Multivariable cox regression analysis further showed that rs1805974 was a significantly favorable prognostic factor for PFS [CC/CG vs. GG: Adjusted HR = 0.62, 95% CI: 0.39-0.99; CC vs. CG/GG: Adjusted HR = 0.56, 95% CI: 0.32-0.97). Similarly, rs13312840 with a small sample size also showed a significant association with PFS (CC vs. CT/TT: Adjusted HR = 25.62, 95% CI: 1.53-428.39). CONCLUSIONS Our findings suggest that NBS1 polymorphisms may be genetic biomarkers for NSCLC prognosis especially PFS with platinum-based chemotherapy in the Chinese population.
Running head : MATHEMATICS IN AUTISM

Although clinical practitioners often express concerns about the mathematical functioning of children with autism spectrum disorder (ASD), the field of mathematics remains a relatively unexplored topic in individuals with ASD. Moreover, research findings are fragmentary and hold inconclusive results. The present study aimed to examine whether grade 1 (aged 6-7 years) to 4 (aged 9-10 years) elementary school children with ASD scored significantly different from age-adequate norms on mathematics. To this end, a multi-componential approach of mathematics was used. Four domains of mathematics were assessed in 121 children with ASD: procedural calculation, number fact retrieval, word/language problems, and time-related competences. All children attended general education classrooms, following the standard curriculum, and were coached by integrated educational services. Children with ASD showed a strength in word/language problems in second and fourth grade. There was evidence of a weakness for procedural calculation in first grade and for time-related competences in first and third grade. In all other cases, average scores were shown. As such, results revealed a profile of strengths, average abilities and weaknesses in mathematics and highlighted the importance of focusing on different domains of mathematics. Since a high variability in mathematical performance could be observed, we recommend an individual assessment when considering the mathematical trajectory of children with ASD. MATHEMATICS IN AUTISM 4
Measurement of malarial infectivity of human populations to mosquitoes in the Madang area, Papua New Guinea

Summary The proportion of blood meals taken on humans which are infectious to mosquitoes in the Madang area, Papua New Guinea was estimated by two methods. In the first, laboratory reared Anopheles farauti were fed on individuals of all ages at village surveys. The results showed that 3·8% of people were infectious and that the mean percentage of mosquitoes which became infected by feeding on these people was 37·9%. From the average proportion of mosquitoes infected, the probability that a mosquito feeding on a human would pick up infection was 0·013±0·005. In the second approach mosquitoes were fed on identified Plasmodium falciparum, P. vivax and P. malariae gametocyte carriers. The results indicated that 46% of gametocyte carriers were infectious and that the mean probability of a mosquito becoming infected after feeding on a gametocyte carrier was 0·151±0·029. Gametocyte prevalence rates in all ages measured over 18 months in three villages averaged 3·3% P. falciparum, 4·0% P. vivax and 0·7% P. malariae, totalling 8·0±0·7%. Combining gametocyte prevalence rates with the probability of a mosquito becoming infected from a gametocyte carrier, the probability of a mosquito becoming infected following a blood meal on a member of the human population was estimated to be 0·012±0·003.
Manufacturing Job Loss in U.S. Deindustrialized Regions—Its Consequences and Implications for the Future

The loss of manufacturing jobs in the United States has been widely noted in the popular press as well as in public policy debate. We examine several of the most prominently made assertions about manufacturing decline and its consequences for deindustrializing metropolitan areas and find not all of them supported by the data. In particular, we find that, given their industrial structure some of these areas performed better than expected, that long-term economic distress was not inevitable, that manufacturing remains an important component in many metropolitan area economies, and that much of the growth in the service sector is based upon or complementary to the existence of manufacturing. We also find that low growth in these deindustrialized areas was due more to these regions losing their market share of individual industries to other U.S. regions than it was to the areas having an adverse industrial structure, that economies that were more diversified in 1980 did not have greater employment growth from 1980-2011 than those that were less diverse, and that declines in manufacturing did result in a movement of jobs from relatively high-wage to relatively low-wage industries and thus a decline in earnings per jobs.
Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors

Persistent relapse to addictive drugs constitutes the most challenging problem in addiction therapy, and is linked to impaired prefrontal cortex regulation of motivated behaviors involving the nucleus accumbens. Using a rat model of heroin addiction, we show that relapse requires long-term potentiation (LTP)-like increases in synaptic strength in the prefrontal cortex projection to the nucleus accumbens. The increased synaptic strength was paralleled by dendritic spine enlargement in accumbens spiny neurons and required up-regulated surface expression of NMDA2b-containing receptors (NR2B). Accordingly, blocking NR2B before reinstating heroin-seeking prevented the induction of LTP-like changes in spine remodeling and synaptic strength, and inhibited heroin relapse. These data show that LTP-like neuroplasticity in prefrontal-accumbens synapses is initiated by NR2B stimulation and strongly contributes to heroin relapse. Moreover, the data reveal NR2B-containing NMDA receptors as a previously unexplored therapeutic target for treating heroin addiction.
What is a reasonable length of employment for health workers in Australian rural and remote primary healthcare services?

BACKGROUND Optimising retention of rural and remote primary healthcare (PHC) workers requires workforce planners to understand what constitutes a reasonable length of employment and how this varies. Currently, knowledge of retention patterns is limited and there is an absence of PHC workforce benchmarks that take account of differences in geographic context and profession. METHODS Three broad strategies were employed for proposing benchmarks for reasonable length of stay. They comprised: a comprehensive literature review of PHC workforce-retention indicators and benchmarks; secondary analysis of existing Australian PHC workforce datasets; and a postal survey of 108 rural and remote PHC services, identifying perceived and actual workforce-retention patterns of selected professional groups. RESULTS The literature review and secondary data analysis revealed little that was useful for establishing retention benchmarks. Analysis of primary data revealed differences in retention by geographic location and profession that took time to emerge and were not sustained indefinitely. Provisional benchmarks for reasonable length of employment were developed for health professional groups in both rural and remote settings. CONCLUSIONS Workforce-retention benchmarks that differ according to geographic location and profession can be empirically derived, facilitating opportunities for managers to improve retention performance and reduce the high costs of staff replacement. WHAT IS KNOWN ABOUT THE TOPIC? Health services located in small rural and remote locations are likely to continue to experience workforce shortages and high costs of recruitment. Health workforce retention is therefore crucial. However, effective rural health workforce planning and use of strategies to maximise retention of existing health workers is hindered by inadequate knowledge about baseline employment-retention patterns. WHAT DOES THIS PAPER ADD? Differences in health worker retention patterns by geographic location and profession are most evident after the first 6 months through until the end of the second year of employment. Health worker-retention benchmarks that differ according to geographic location and profession are proposed. WHAT ARE THE IMPLICATIONS FOR PRACTITIONERS? Benchmarking workforce retention in comparable health services can enable identification of best practice and the underpinning retention strategies. Workforce planners can use this, together with knowledge of baseline retention patterns and the high cost of staff replacement, to guide the design, timing and implementation of cost-neutral retention strategies.
Aspirin response: Differences in serum thromboxane B2 levels between clinical studies

Abstract Serum thromboxane B2 (TxB2) is a specific marker of platelet inhibition by aspirin. Yet, TxB2 levels differ by up to 10-fold between some aspirin-treated patient cohorts. This study aimed to identify factors responsible for differences in serum TxB2 between cohorts in the ADRIE study (n = 657) and the BOSTON study (n = 678) of aspirin-treated cardiovascular patients originally tested with different ELISA assays. TxB2 levels were assessed in representative subgroups of the two cohorts (34 samples in BOSTON and 39 in ADRIE) by both ELISAs, as well as liquid chromatography and tandem mass spectroscopy (MS). A multivariate analysis was performed on the whole cohort database to identify determinants of the difference of TxB2 levels between cohorts. There was no systematic bias between the original ELISA TxB2 values and the MS values and the median difference was small, 0.12 ng/ml, thus not explaining the difference between median TxB2 levels in the two study populations (7 and 0.6 ng/ml in the ADRIE and BOSTON studies, respectively). In the combined dataset of the ADRIE and BOSTON cohorts (n = 1342), body mass index, age, gender, aspirin dose, time from aspirin intake to blood draw, NSAID intake, platelet count and C-reactive protein were significantly associated with TxB2 levels. After adjustment for patient characteristics, the difference between cohorts did not decrease. Unexplained differences in serum TxB2 levels in different populations of aspirin-treated cardiovascular patients suggest that further studies are needed to confirm the role of serum TxB2 level as a prognostic factor or rather as a marker of therapeutic observance.