Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults

Background: Executive function tends to decline as people age. Transcranial direct current stimulation (tDCS) is assumed to have beneficial effects on various cognitive functions. Some prior investigations have shown that repeated sessions of tDCS enhance the executive function performance of healthy elderly people by mediating cognitive training gains. However, studies of the effect of long-term stimulation on executive function without cognitive training are absent. Objective: The purpose of this study was to explore whether the executive function of healthy older adults could be enhanced with long-term tDCS alone applied on the prefrontal cortex. Methods: Sixty-five cognitively normal older adults were enrolled and randomly assigned to two groups: an anodal tDCS group and a sham tDCS group. The participants in the two groups received anodal stimulation or sham stimulation over the left dorsolateral prefrontal lobe, for 30 min per day for 10 consecutive days. Executive function was tested before stimulation, immediately after stimulation and 3 months after stimulation. Three core components of executive function were tested using a two-back task for updating, a flanker task for inhibition, and a switching task for shifting. Results: Across the three tasks, we failed to discover any differences between the anodal and sham stimulation. Moreover, we found no statistically significant stimulation effect in the follow-up session. Conclusion: Our study does not support the assumption that multiple sessions of tDCS that are independent of cognitive training have a beneficial effect on executive function in healthy older adults, presumably because the effect of the stimulation lies in its amplification of training gains. It indicates that combining traditional cognitive training methods with brain stimulation may be a better approach to improve older adults’ executive function.
P649: Transcranial direct current stimulation (tDCS) of left parietal cortex facilitates gesture processing in healthy subjects

Gesture processing deficits constitute a key symptom of apraxia, a disorder of motor cognition frequently observed after left-hemispheric stroke. The clinical relevance of apraxia stands in stark contrast to the paucity of therapeutic options available. Transcranial direct current stimulation (tDCS) is a promising tool for modulating disturbed network function after stroke. Here, we investigate the effect of parietal tDCS on gesture processing in healthy human subjects. Neuropsychological and imaging studies suggest that the imitation and matching of hand gestures involve the left inferior parietal lobe (IPL). Using neuronavigation based on cytoarchitectonically defined anatomical probability maps, tDCS was applied over left IPL-areas PF, PFm, or PG in healthy participants (n = 26). Before and after tDCS, subjects performed a gesture matching task and a person discrimination task for control. Changes in error rates and reaction times were analyzed for the effects of anodal and cathodal tDCS (compared with sham tDCS). Matching of hand gestures was specifically facilitated by anodal tDCS applied over the cytoarchitectonically defined IPL-area PFm, whereas tDCS over IPL-areas PF and PG did not elucidate significant effects. Taking into account tDCS electrode size and the central position of area PFm within IPL, it can be assumed that the observed effect is rather the result of a combined stimulation of the supramarginal and angular gyrus than an isolated PFm stimulation. Our data confirm the pivotal role of the left IPL in gesture processing. Furthermore, anatomically guided tDCS of the left IPL may constitute a promising approach to neurorehabilitation of apraxic patients with gesture processing deficits.
Impaired endogenous fibrinolysis in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention is a predictor of recurrent cardiovascular events: the RISK PPCI study

Aims The endogenous fibrinolytic system serves to prevent lasting thrombotic occlusion and infarction following initiation of coronary thrombosis. We aimed to determine whether impaired endogenous fibrinolysis can identify patients with ST-segment elevation myocardial infarction (STEMI) who remain at high cardiovascular risk despite dual antiplatelet therapy (DAPT). Methods and results A prospective, observational study was conducted in 496 patients presenting with STEMI for primary percutaneous coronary intervention (PPCI). Blood was tested on arrival pre-PPCI, at discharge and at 30 days to assess thrombotic status using the automated point-of-care global thrombosis test and patients followed for 1 year for major adverse cardiovascular events (MACEs). Endogenous fibrinolysis was significantly impaired [baseline lysis time (LT) ≥2500 s] in 14% of patients and was highly predictive of recurrent MACE [hazard ratio (HR) 9.1, 95% confidence interval (CI) 5.29-15.75; P < 0.001], driven by cardiovascular death (HR 18.5, 95% CI 7.69-44.31; P < 0.001) and myocardial infarction (HR 6.2, 95% CI 2.64-14.73; P < 0.001), particularly within 30 days. Fibrinolysis remained strongly predictive of MACE after adjustment for conventional risk factors (HR 8.03, 95% CI 4.28-15.03; P < 0.001). Net reclassification showed that adding impaired fibrinolysis improved the prediction of recurrent MACE by >50% (P < 0.001). Patients with spontaneous ST-segment resolution pre-PPCI had more rapid, effective fibrinolysis [LT 1050 (1004-1125) s vs. 1501 (1239-1997) s, P < 0.001] than those without. Lysis time was not altered by standard of care STEMI treatment including DAPT and was unchanged at 30 days. Conclusion Endogenous fibrinolysis assessment can identify patients with STEMI who remain at very high cardiovascular risk despite PPCI and DAPT. Further studies are needed to assess whether these patients may benefit from additional, personalized antithrombotic/anticoagulant medication to reduce future cardiovascular risk. Clinical trial registration http://www.clinicaltrials. gov. Unique identifier: NCT02562690.
Nutrient and ruminal fermentation profiles of Camellia seed residues with fungal pretreatment

Objective The experiment was conducted to evaluate the effects of four fungal pretreatments on the nutritional value of Camellia seed residues, and to evaluate the feeding value of pre-treated Camellia seed residues for ruminants. Methods Camellia seed residues were firstly fermented by four lignin degrading fungi, namely, Phanerochaete chrysosporium (P. chrysosporium)-30942, Trichoderma koningiopsis (T. koningiopsis)-2660, Trichoderma aspellum (T. aspellum)-2527, or T. aspellum-2627, under solid-state fermentation (SSF) conditions at six different incubation times. The nutritional value of each fermented Camellia seed residues was then analyzed. The fermentation profiles, organic matter degradability and metabolizable energy of each pre-treated Camellia seed residue were further evaluated using an in vitro rumen fermentation system. Results After 5 days of fermentation, P. chrysosporium-30942 had higher degradation of lignin (20.51%), consumed less hemicellulose (4.02%), and the SSF efficiency reached 83.43%. T. koningiopsis-2660 degraded more lignin (21.54%) and consumed less cellulose (20.94%) and hemicellulose (2.51%), the SSF efficiency reached 127.93%. The maximum SSF efficiency was 58.18% for T. aspellum-2527 and 47.61% for T. aspellum-2627, appeared at 30 and 15 days respectively. All the fungal pretreatments significantly improved the crude protein content (p<0.05). The Camellia seed residues pretreated for 5 days were found to possess significantly increased organic matter degradability, volatile fatty acid production and metabolizable energy (p<0.05) after the treatment of either P. chrysosporium-30942, T. koningiopsis-2660 or T. aspellum-2527. The fungal pretreatments did not significantly change the rumen fermentation pattern of Camellia seed residues, with an unchanged ratio of acetate to propionate. Conclusion The fungi showed excellent potential for the solid-state bioconversion of Camellia seed residues into digestible ruminant energy feed, and their shorter lignin degradation characteristics could reduce loss of the other available carbohydrates during SSF.
A Priori Estimates of the Generalization Error for Two-layer Neural Networks

New estimates for the generalization error are established for the two-layer neural network model. These new estimates are a priori in nature in the sense that the bounds depend only on some norms of the underlying functions to be fitted, not the parameters in the model. In contrast, most existing results for neural networks are a posteriori in nature in the sense that the bounds depend on some norms of the model parameters. The error rates are comparable to that of the Monte Carlo method for integration problems. Moreover, these bounds are equally effective in the over-parametrized regime when the network size is much larger than the size of the dataset.
Testosterone correlates of mate guarding, singing and aggressive behaviour in male barn swallows,
 Hirundo rustica
 


Abstract Sexual and social behaviour in male birds is largely controlled by gonadal secretions, most notably testosterone. In this paper the relationships between natural testosterone plasma concentrations and mate guarding, singing and rates of aggression in male barn swallows are reported. Behaviour of individually marked male swallows was observed in three breeding colonies. Individual mate-guarding rate was positively correlated with individual testosterone plasma level adjusted for stage in the breeding cycle in which blood was sampled. Mean mate-guarding rates by males at different stages in the breeding cycle were also positively correlated with mean testosterone levels in the population. Individual singing and fighting rates did not show a significant correlation with testosterone but mean singing rate in the population was positively correlated with mean testosterone levels. Male tail length, which is a morphological trait currently under directional sexual selection, was inversely correlated with mate-guarding rates after controlling statistically for the effects of testosterone.
The commuting system of Serengeti spotted hyaenas: how a predator copes with migratory prey. III. Attendance and maternal care

Abstract Abstract. In the Serengeti, spotted hyaenas spent 46-62% of the year foraging by commuting between their clan's territory and the nearest herds of migratory herbivores. During the first 12 months of their life, cubs were stationed at the communal den and were dependent on milk from their mother ('denning female'). This study assessed the impact of the commuting system on maternal care in terms of den attendance and commuting effort, and its fitness consequences in terms of cub growth and survival. Duration of absence intervals decreased while frequency of maternal visits and cub growth rates increased with prey abundance. Mothers of singletons attended their cubs at the same rate as mothers of twins. Growth rates of singletons were higher than those of twins at each level of prey abundance. Cubs growing at higher long-term rates had a significantly better chance of survival. When migratory herbivores were absent from the clan's territory, denning females visited the den more often than non-denning females and males because the mean duration of their commuting trips was shorter (3-4 days versus 6-10 days). The higher attendance by denning females required an increase in travelling effort by a factor of 2·6-3·2 above the level of non-denning females and males. Because maternal effort was highest when cub growth was at a minimum, maternal fitness would be maximized by commuting as little as possible.
Possible male coalitions in a solitary mongoose

Abstract Abstract. Slender mongooses, Herpestes sanguineus , are solitary but males sometimes form loose, non-aggressive associations. Since 1975, sightings of marked animals in the Serengeti National Park, Tanzania, indicate that (1) up to four males may jointly use the same home range, each of which may overlap the ranges of up to six females but no other males; (2) association membership can be stable for up to 7 years; (3) members of an association generally appear on the study site together as young adults, presumably having immigrated from off the study site; and (4) larger associations have persisted for longer periods. DNA fingerprinting confirms that paternity is not monopolized by any single association member, and that association members can be closely related. These results suggest that associations of male slender mongooses are coalitions that exclude other males from access to females within a common territory. Coalitions have also been reported within other mongoose species; this form of escalated mate competition, which has been generally associated only with certain primates and felids, may be more widely distributed.
Transcutaneous Electrical Acupoint Stimulation Improves Immunological Function During the Perioperative Period in Patients With Non-Small Cell Lung Cancer Undergoing Video-Assisted Thoracic Surgical Lobectomy

The immunological function of patients with malignant tumors may be suppressed during the perioperative period. However, details on the effects of transcutaneous electrical acupoint stimulation (TEAS) on immunological function are relatively lacking. We designed this study to examine the effects of TEAS on the immunological function of patients with non-small cell lung cancer (NSCLC) during the perioperative period. Participants (n = 144) were enrolled and randomly assigned into group TEAS or group sham TEAS. TEAS on bilateral Feishu (BL13), Hegu (L14), and Zusanli (ST36) was performed continuously throughout the procedure. The primary outcome was the quantities of natural killer (NK) cells at 30 minutes before induction (T0), 5 minutes after intubation (T1), at the beginning of the operation (T2), at the beginning of the lobectomy (T3), at the beginning of the lymphadenectomy (T4), and immediately after extubation (T5). The secondary outcomes were the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) at T0 to T5, the mean arterial pressure (MAP) and heart rate (HR), the intraoperative consumption of propofol and remifentanil, the incidence of hypoxemia, postoperative nausea and vomiting (PONV), and the length of hospital stay. The quantities of NK cells were decreased in group sham TEAS after intubation compared to that in group TEAS, while the quantities of NK cells in group TEAS were similar at T0 to T5. Meanwhile, the quantities of NK cells in group sham TEAS at T1 (P = .012), T2 (P < .001), T3 (P = .027), T4 (P = .045), and T5 (P = .021) were lower than those in group TEAS. In group TEAS, the serum levels of TNF-α were lower at T1 to T5, while the levels of IL-6 were lower at T2 to T5. Furthermore, the intraoperative MAP and HR were more stable, the total propofol and remifentanil consumptions were lower, and the length of hospital stay was shorter than those in group sham TEAS. The application of TEAS can effectively reverse the decrease in NK cells, decrease the serum levels of TNF-α and IL-6, maintain hemodynamic stability during the perioperative period, decrease the consumption of propofol and remifentanil, and shorten the length of the hospital stay.
Pruning Filter via Geometric Median for Deep Convolutional Neural Networks Acceleration

Previous works utilized "smaller-norm-less-important" criterion to prune filters with smaller norm values in a convolutional neural network. In this paper, we analyze this norm-based criterion and point out that its effectiveness depends on two requirements that not always met: (1) the norm deviation of the filters should be large; (2) the minimum norm of the filters should be small. To solve this problem, we propose a novel filter pruning method, namely Filter Pruning via Geometric Median (FPGM), to compress the model regardless of those two requirements. Unlike previous methods, PFGM compresses CNN models by determining and pruning those filters with redundant information via Geometric Median (GM), rather than those with "relatively less" importance. When applied to two image classification benchmarks, our method validates its usefulness and strengths. Notably, on Cifar-10, PFGM reduces more than 52% FLOPs on ResNet-110 with even 2.69% relative accuracy improvement. Besides, on ILSCRC-2012, PFGM reduces more than 42% FLOPs on ResNet-101 without top-5 accuracy drop, which has advanced the state-of-the-art.
Male response to female vocalizations in the carpenter frog, Rana virgatipes


Abstract Abstract. Female carpenter frogs give a low-intensity, high-frequency, single-note call during courtship. The female call is distinct from the similar sounding male single-note aggressive call in having higher dominant and secondary dominant frequencies, and less pronounced harmonics. Playback experiments were conducted in which synthetic variants of the female call were played to territorial males. Male response to natural female calls was similar to their response to male vocalizations: there was a switch from advertisement calls to a high rate of single-note aggressive calls. Males did not discriminate between the natural female call and a synthetic call of lower dominant frequency, or between two series of four natural female calls with different inter-note durations. Finally, the rate of multi-note aggressive calls (encounter calls) was greater when the natural female call was accompanied by the movement of a life-sized rubber model of a frog placed within 20 cm of the male. Therefore, territorial males obtain information from both the sound and mechanical disturbance of the water.
Variation of Retinal and Choroidal Vasculatures in Patients With Age-Related Macular Degeneration.

Purpose To investigate variations in chorioretinal vasculatures in fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD). Methods We included fellow eyes of consecutive patients with unilateral nAMD from swept source optical coherence tomography (SS-OCT) angiography database. Vascular and nonvascular indices were determined based on SS-OCT and SS-OCT angiography images. Variation of the vascular or nonvascular index was compared between fellow eyes with and without early AMD. Results In 146 fellow eyes, 88 (60.3%) had early AMD and 58 (39.7%) had a normal fundus. Vascular density (VD) values of the superficial and deep retinal capillary plexus and choriocapillaris were smaller in eyes with early AMD than in those without (P < 0.001, P = 0.001, P = 0.006, respectively). Flow void area in choriocapillaris was greater in eyes with early AMD than those without (P = 0.015). In 88 fellow eyes with early AMD, vascular indices of the retina were correlated with those of choroid while nonvascular indices were not. Fellow eyes of patients with classic exudative AMD had greater foveal avascular zone area and smaller VD values of the deep retinal capillary plexus than those with polypoidal choroidal vasculopathy (P < 0.001, P = 0.004). Conclusions In addition to vascular insufficiency in the choroid or choriocapillaris, retinal vascular alteration was apparent in eyes with early AMD. It may suggest that retinal vessels were involved in the pathogenesis of AMD even while changes in nonvascular components of the retina were not yet apparent.
Mode Transition of Droplet Formation in a Semi-3D Flow-Focusing Microfluidic Droplet System

Uniform droplets have significant potential in many biological applications due to their higher surface area to volume ratio. This paper proposed a semi-three-dimensional (sime-3D) flow-focusing microfluidic system, which was fabricated using the multi-layer soft lithography method. Based on the semi-3D structure, we focus on droplets formation modes and droplet uniformity at different bulk concentration of surfactant. The relationships between droplets uniformity, droplets breakup processes (jetting mode, dripping mode and tip-streaming mode) and surfactant concentration was investigated. It was found that three droplet generation modes occur through adjusting the pressure ratio in two inlet channels and the concentration of surfactant in continuous phase liquid. The jetting mode would transform to the dripping mode or the tip-streaming mode as the pressure ratio in different surfactant concentrations increased. Furthermore, the uniformity of droplets could be improved through the transition of jetting to dripping mode. We assumed that the uniformity declined through the transition of jetting to tip-streaming, and explored the specific transitions from jetting to dripping mode and tip-streaming mode. Dripping mode leads to high droplet uniformity, and generation frequency decreases with increasing pressure ratio. Tip-streaming mode is considered as an extreme state of jetting mode, leading to higher formation frequency and smaller droplet size at low uniformity.
Do Medicare Advantage Rebates Reduce Enrollees’ Out-of-Pocket Spending?

The majority of Medicare Advantage (MA) plans receive payments that exceed their costs of providing basic Medicare benefits. There is controversy about whether these payments are passed on to the enrollees as supplemental benefits or are retained by plans. We used survey data on MA beneficiaries’ actual out-of-pocket (OOP) spending linked to MA payment information to test whether higher plan payments and rebates lowered enrollee OOP spending. We used instrumental variables regression models to address concerns that plan payments and rebates may reflect anticipation of enrollees with particular health-spending profiles. We found that beneficiaries recovered only $0.65 of every $1.00 in payments exceeding fee-for-service spending through lower OOP spending but more than fully recovered the value of the rebates supporting supplemental benefits.
Outstanding Photoluminescence in Pr3+-Doped Perovskite Ceramics

Ba (Zr0.2Ti0.8) O3-50% (Ba0.7Ca0.3) TiO3 (BZT-0.5BCT) ceramics with different doping contents of Pr3+ were prepared by the conventional solid-state reaction. The phase structure and crystallinity of the fabricated ceramics were investigated by X-ray diffraction, Raman spectroscopy, and scanning electron microscopy. Photoluminescence (PL) emission spectra were measured to analyze the PL characteristics. The strong intensities of a green band at 489 nm and a red band at 610 nm were observed. The maximum emission intensity of the PL spectrum was achieved in the BZT-0.5BCT ceramic with 0.2% mol of Pr3+ ions. Furthermore, the PL spectra of BZT-0.5BCT ceramics were found to be sensitive to polarization of the ferroelectric ceramics. Compared with the unpoled ceramics, the green emission increased about 42% and a new emission peak at 430 nm appeared for the poled ceramics. With excellent intrinsic ferroelectricity and an enhanced PL property, such material has potential to realize multifunctionality in a wide application range.
Income Inequality and Population Health: A Global Gradient?

Cross-national empirical research about the link between income inequality and population health produces conflicting conclusions. We address these mixed findings by examining the degree to which the income inequality and health relationship varies with economic development. We estimate fixed-effects models with different measures of income inequality and population health. Results suggest that development moderates the association between inequality and two measures of population health. Our findings produce two generalizations. First, we observe a global gradient in the relationship between income inequality and population health. Second, our results are consistent with income inequality as a proximate or conditional cause of lower population health. Income inequality has a 139.7% to 374.3% more harmful effect on health in poorer than richer countries and a significantly harmful effect in 2.1% to 53.3% of countries in our sample and 6.6% to 67.6% of the world’s population but no significantly harmful effect in richer countries.