Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of non-essential amino acids (proline and glutamic acid) and sugar polyol (sorbitol) on brood of honey bees

Dietary nutrients provide fuel for the growth and development of insects as well as chemicals for their tissue construction. Apis mellifera L. , an important pollinator, collects nectar and pollens from different plants to get their nutritional needs. Honey bees use protein for growth and development and carbohydrates as energy sources. Pollens predominantly contain proline and glutamic acid (non-essential amino acids). This is the first study to evaluate the role of proline, glutamic acid and sorbitol on bee broods. The composition of the diet can optimize the in vitro rearing process. Therefore, we elaborated on the possible impact of these amino acids and sugar alcohol on bee broods. This study aimed to achieve this objective by rearing honey bee larvae under different concentrations of proline, glutamic acid, and sorbitol (1, 4 and 8%), which were supplemented into the standard larval diet. The supplementation of proline helped the quick development of larvae and pupae of honey bees, whereas developmental time only decreased in pupae in the case of glutamic acid. The duration of the total bee brood development was the shortest (20.1 and 20.6 days) on Pro8 and Glu4, respectively. Proline only increased larvae survival (93.8%), whereas glutamic acid did not increase the survival of any brood stage. Pupal and adult weights were also increased with proline and glutamic acid-supplemented diets. Sorbitol did not change the developmental period of the honey bee brood but increased larval survival (93.7%) only at the lowest concentration (Sor1). The small concentration of sorbitol can be used to increase the survival of the honey bee brood. However, a higher concentration (Sor8) of sorbitol reduced the body weight of both pupae and adults. This study predicted that rearing bee brood could be one of the factors for the selectivity of pollen with higher proline and glutamic acid during the foraging of bees.
Impacts of the development of mineral metal resources on surface water quality in the Mongolian Plateau based on meta-analysis

The mining of metal resources is one of the major sources of heavy metals in surface water, but studies on the different characteristics of the impact of the exploitation of mineral metal resources on surface water from a large-scale perspective are lacking. In the present study, we quantified the impacts of mineral metal resource development on As, Cu, Cr, Pb, Zn, Hg, Ni, Cd, Mn, and Fe in the overlying water and sediments of surface water under different scenarios (i.e., different geographic units and different mined metal types) using meta-analysis for the Mongolian Plateau of Mongolia and the Inner Mongolia Autonomous Region of China, which is rich in mineral metal resources and has high exploitation and use intensity. Finally, funnel plots and Egger’s regression analysis were used to test the publication bias of the data. The results show that the order of heavy metal content in the overlying water of the Mongolian Plateau was Fe > Mn > As > Zn > Cu > Pb > Cr > Ni > Cd > Hg, and the order of heavy metal content in the sediment was Fe > Mn > Zn > Cr > Pb > Ni > Cu > As > Cd > Hg. In addition, As, Cr, Zn, Hg, Cd, and Pb in overlying water exceeded the standard to different degrees, among which the contents of As and Pb were 1.4 and 1.3 times higher than the World Health Organization guideline, and the contents of Cr, Pb, Hg, Cd were 1.5, 1.3, 25.4, 2.6 times Chinese environmental quality standards for surface water, and the contents of As, Pb, Zn, Hg were 1.4, 1.3, 4.7, 12.7 times Mongolian water quality standards, respectively. The content of As in sediments was 2.6 times the background value of soil environmental quality in Inner Mongolia. Significant differences existed in the content of heavy metal pollutants in surface water of different countries; the content of heavy metals in the overlying water was significantly higher in Inner Mongolia Autonomous Region of China than in Mongolia. Copper and molybdenum polymetallic mines significantly increased the content of Cd, Cr, Cu, Fe, Hg, Pb, and Zn in the overlying water, while the content of As, Cr, Pb, and Zn in overlying water increased significantly due to lead–zinc mining. However, the mining of gold–silver, lead–zinc, copper–molybdenum, and other polymetallic mines all significantly affected the concentration of As in sediments. The results of the present study can provide data support for environmental protection and the restoration of surface water in metal mining areas of the Mongolian Plateau.
Urban Expansion and Loss of Agricultural Land in Osogbo, Osun State Nigeria, using Multi-Temporal Imageries

Osogbo, the state capital of Osun State is one of the rapidly urbanizing cities in Nigeria. This article examined urban expansion and the transition of agricultural land in Osogbo with the use of multi-temporal imageries between 1986 and 2018. Large amounts of cultivated land has been transformed into other land uses in the past 31 years. This paper presents the process of the loss of agricultural land and urban growth in Osogbo with the use of remote sensing and GIS. Landsat imageries for 1986, 2002 and 2018 were used to analyse land use and land cover change. Supervised image classification was applied to classify the images into different land use categories. Six land use classes were identified: built-up area, water body, cultivated area, gallery zone, dense vegetation and rocky outcrops. Built-up areas (residential, educational and industrial areas) have greatly increased while agricultural lands (i.e. farmland and wetland) have considerably decreased during the study period. Built-up area covered 7.06% in 1986 but increased to 53.61% in 2018 while agricultural land decreased from 86.28% to 41.53% in the same period. The study therefore recommends that government should integrate agricultural lands into urban land use, planning for efficient management and protection of the dwindling agricultural space.
Comparative genomics of Myxococcus and Pyxidicoccus, including the description of four novel species: Myxococcus guangdongensis sp. nov., Myxococcus qinghaiensis sp. nov., Myxococcus dinghuensis sp. nov., and Pyxidicoccus xibeiensis sp. nov.

Myxobacteria are recognized for fascinating social behaviors and producing diverse extracellular active substances. Isolating novel myxobacteria is of great interest in the exploitation of new antibiotics and extracellular enzymes. Herein, four novel strains were isolated from Dinghu Mountain Biosphere Reserve, Guangdong province, and Qinghai virgin forest soils, Qinghai province, China. The phylogenetic analysis based on 16S rRNA gene and genomic sequences indicated that the four strains belong to the genera Myxococcus and Pyxidicoccus, sharing the highly similarities of 16S rRNA gene with the genera Myxococcus and Pyxidicoccus (99.3–99.6%, respectively). The four strains had average nucleotide identity (ANI) values of 82.8–94.5%, digital DNA–DNA hybridization (dDDH) values of 22.2–56.6%, average amino acid identity (AAI) values of 75.8–79.1% and percentage of conserved protein (POCP) values of 66.4–74.9% to members of the genera Myxococcus and Pyxidicoccus. Based on phylogenetic analyses, physiological and biochemical characteristics, and comparative genomic analyses, we propose four novel species of the genera Myxococcus and Pyxidicoccus and further supported the two genera above represented the same genus. Description of the four novel species is Myxococcus guangdongensis sp. nov. (K38C18041901T = GDMCC 1.2320T = JCM 39260T), Myxococcus qinghaiensis sp. nov. (QH3KD-4-1T = GDMCC 1.2316T = JCM 39262T), Myxococcus dinghuensis sp. nov. (K15C18031901T = GDMCC 1.2319T = JCM 39259T), and Pyxidicoccus xibeiensis sp. nov. (QH1ED-7-1T = GDMCC 1.2315T = JCM 39261T), respectively. Furthermore, comparative genomics of all 15 species of the genera Myxococcus and Pyxidicoccus revealed extensive genetic diversity. Core genomes enriched more genes associated with housekeeping functional classes while accessory genomes enriched more genes related to environmental interactions, indicating the former is relatively indispensable compared to signaling pathway genes. The 15 species of Myxococcus and Pyxidicoccus also exhibited great gene diversity of carbohydrate-active enzymes (CAZymes) and secondary metabolite biosynthesis gene clusters (BGCs), especially related to glycosyl transferases (GT2 and GT4), glycoside hydrolases (GH13 and GH23), non-ribosomal peptide synthetases (NRPS), and Type I polyketide synthase (PKS)/NRPS hybrids.
The impact of tumor associated macrophages on tumor biology under the lens of mathematical modelling: A review

In this article, we review the role of mathematical modelling to elucidate the impact of tumor-associated macrophages (TAMs) in tumor progression and therapy design. We first outline the biology of TAMs, and its current application in tumor therapies, and their experimental methods that provide insights into tumor cell-macrophage interactions. We then focus on the mechanistic mathematical models describing the role of macrophages as drug carriers, the impact of macrophage polarized activation on tumor growth, and the role of tumor microenvironment (TME) parameters on the tumor-macrophage interactions. This review aims to identify the synergies between biological and mathematical approaches that allow us to translate knowledge on fundamental TAMs biology in addressing current clinical challenges.
Exoskeleton Control System Based on Motor-Imaginary Brain–Computer Interface

С. Ю. Гордлеева, к. ф. -м. н. , научный сотрудник лаборатории математического моделирования в нейронауке1; М. В. Лукоянов, ассистент кафедры нормальной физиологии им. Н. Ю. Беленкова2; младший научный сотрудник лаборатории разработки мозго-машинных интерфейсов1; С. А. Минеев, к. ф. -м. н. , доцент кафедры информационных технологий в физических исследованиях1; М. A. Хоружко, инженер лаборатории разработки интеллектуальных биомехатронных технологий1; В. И. Миронов, младший научный сотрудник лаборатории разработки интеллектуальных биомехатронных технологий1; А. Я. Каплан, д. б. н. , зав. лабораторией нейрофизиологии и нейрокомпьютерных интерфейсов3; зав. лабораторией разработки мозго-машинных интерфейсов1; В. Б. Казанцев, д. ф. -м. н. , зав. кафедрой нейротехнологий, проректор по научной работе1
Assessment of Beef Cattle Husbandry Practices in North Shoa Zone, Amhara Region, Ethiopia

The study was conducted with the objectives of assessment of beef cattle husbandry practice in North Shoa Zone, Amhara Regional State. The data were collected through semi structured questionnaire, group discussions and field observation. A total of 490 households were randomly selected and interviewed by using pre-tested questioner. Statistical package for social science (SPSS 16) were used to analyze the collected data. Majority of respondents 70.0% 73.9% and 61.9% provide supplementary feed for their calves, manage their calves together with other animal and fatten exotic breeds respectively. Based on the respondent’s response 87.6% practice culling and the main reasons of culling animals were aging (52.2%), Infertility (10.3%), unhealthy (22.8%), deformed conformation (6.2%) and unwanted color (0.3%). Modern treatment (85%) and government clinics were more preferred by the farmers and 89.4% of farmers vaccinate their animal. Most farmers 57.7% and 67.9% have their own grazing land and conserve both hey and straw respectively. Concentrate or industrial by product utilization was limited wheat bran utilization was zero in Basonaworana and Ankober woreda and oilseed cake also zero in Minjarshenkora, Efratanagidim and Ankober Woredas. 60.8% of the respondents provide separate house for their cattle. The intervention which will be done in the future should consider the existing traditional management and herding practices.
Effect of gangue composition on assimilation characteristic of iron ore in the sintering process

A new method for determining the timing of assimilation reaction by measuring the change of electrical conductivity of assimilation reaction contact surface was proposed. Experimental study of lowest assimilation temperature (LAT) of 15 iron ores were conducted, and pure reagents simulating tests of LAT were also carried out for purpose of achieving the influence of gangue composition on LAT. The results show that for pure reagents, the increase of Al2O3 and MgO promoted the LAT, low SiO2 (≤3.0 wt%) was good to the LAT, but high SiO2 (>3.0 wt%) was bad, LOI was favorable for LAT. For iron ores, the influence of gangue composition on LAT is basically the same as that of pure reagents, but the linear correlation coefficient is not obvious. It is better to study the effect of synergy of SiO2, Al2O3 and MgO content in iron ore on LAT than that of single factor.
Low expression of INMT is associated with poor prognosis but favorable immunotherapy response in lung adenocarcinoma

Background: The expression of INMT (indolethylamine N-methyltransferase) has been reported to be downregulated in non-small-cell lung cancer (NSCLC). However, the role of INMT in NSCLC remains elusive. We aim to investigate the underlying mechanisms and clinical value of INMT in NSCLC, especially in lung adenocarcinoma (LUAD). Methods: Gene expression cohorts from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed to assess the effect of INMT on NSCLC. Gene expression data from an immunotherapy cohort were used to investigate the association of INMT with immunotherapy in NSCLC. Results: INMT expression was significantly downregulated in NSCLC compared with adjacent normal tissues. Downregulated INMT was associated with poor overall survival in LUAD, but not in lung squamous carcinoma. Multivariate Cox regression analysis suggested that INMT was an independent prognostic marker in LUAD. INMT had a reference value in the diagnosis and prognostic estimation of LUAD. Gene set enrichment analysis showed that pathways of the cell cycle and DNA damage response were enriched in the INMT low-expression group. The top 10 hub genes upregulated in the INMT low-expression group mainly activated the cell cycle pathway. In addition, more frequently mutated TP53 genes, higher aneuploidy scores, a fraction of genomes altered, MANTIS scores, and tumor mutation burden were found in tumors with low expression of INMT. Furthermore, patients with low expression of INMT showed favorable clinical benefits to anti-PD-1 treatment with higher enrichment scores of immune-related signatures. Conclusion: The low expression of INMT was associated with poor prognosis but favorable immunotherapy response in LUAD. INMT may affect the progression of LUAD by regulating the cell cycle and may serve as a valuable independent prognostic biomarker in patients with LUAD.
Southern Hemisphere Atmospheric Blocking in CMIP5 and Future Changes in the Australia‐New Zealand Sector

Many general circulation models fail to capture the observed frequency of atmospheric blocking events in the Northern Hemisphere; however, few studies have examined models in the Southern Hemisphere and those studies that have, have often been based on only a few models. To provide a comprehensive view of how the current generation of coupled general circulation models performs in the Southern Hemisphere and how blocking frequency changes under enhanced greenhouse gas forcing, we examine the output of 23 models from the Coupled Model Intercomparison Project Phase 5 (CMIP5). We find that models have differing biases during winter, when blocking occurrence is highest, though models underestimate blocking frequency south of Australia during summer. We show that models generally have a reduction in blocking frequency with future anthropogenic forcing, particularly in the Australia‐New Zealand sector with the number of winter blocked days reduced by about one third by the end of the 21st century.
An extension of the results of hirsch on systems of differential equations which are competitive or cooperative

A vector field in n-space determines a competitive (or cooperative) system of differential equations provided all the off-diagonal terms of its Jacobian matrix are nonpositive (or nonnegative). The principal result is that limit sets of such systems cannot be more complicated than invariant sets of systems of one lower dimension. In fact orthogonal projection along any positive direction maps a limit set homeomorphically and equivariantly onto an invariant set of a Lipschitz vector field in a hyperplane. Limit sets are nowhere dense, unknotted and unlinked. In dimension 2 every trajectory is eventually monotone. In dimension 3 a compact limit set which does not contain an equilibrium is a closed orbit or a cylinder
Two-dimensional, intratidal model study of salinity intrusion structure and motion in partially-mixed estuaries (Virginia)

A two-dimensional, longitudinal-vertical model for partially-mixed estuaries has been developed. The model provides intratidal predictions of surface level, velocity, and salinity through a semi-implicit finite-difference solution to the continuity and momentum equations and an explicit finite-difference solution to the salinity equation. The model was verified through comparison with analytical solutions, laboratory data, and prototype data. Following verification, the model was used to simulate the destratification-stratification cycle which occurs in the James River Estuary, Virginia, coincident with the spring-neap tidal cycle. In a second application to the James, a simulation of the movement of the salinity intrusion following a storm-generated freshwater flow pulse was conducted. Investigations were conducted into the reaction of a hypothetical estuary to step-like and pulse-like alterations in wind stress, tide range, boundary conditions and flow. It was noted that the reaction time-scale of the estuary was much longer than the time-scale of alterations in the forcing functions. Thus, in prototype estuaries in which forcing functions are periodic and/or randomly superimposed, truly steady-state conditions are never attained.
Editorial: Monocot phylogenetics and trait evolution

COPYRIGHT © 2022 Remizowa, Graham and Rudall. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. TYPE Editorial PUBLISHED 10 November 2022 DOI 10.3389/fpls.2022. 1076169
Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma

Dedifferentiated liposarcoma (DDLPS) is an aggressive adipogenic cancer with poor prognosis. DDLPS tumors are only modestly sensitive to chemotherapy and radiation, and there is a need for more effective therapies. Genetically, DDLPS is characterized by a low tumor mutational burden and frequent chromosomal structural abnormalities including amplification of the 12q13-15 chromosomal region and the MDM2 gene, which are defining features of DDLPS. The MDM2 protein is an E3 ubiquitin ligase that targets the tumor suppressor, p53, for proteasomal degradation. MDM2 amplification or overexpression in human malignancies is associated with cell-cycle progression and worse prognosis. The MDM2–p53 interaction has thus garnered interest as a therapeutic target for DDLPS and other malignancies. MDM2 binds p53 via a hydrophobic protein interaction that is easily accessible with synthetic analogues. Multiple agents have been developed, including Nutlins such as RG7112 and small molecular inhibitors including SAR405838 and HDM201. Preclinical in vitro and animal models have shown promising results with MDM2 inhibition, resulting in robust p53 reactivation and cancer cell death. However, multiple early-phase clinical trials have failed to show a benefit with MDM2 pathway inhibition for DDLPS. Mechanisms of resistance are being elucidated, and novel inhibitors and combination therapies are currently under investigation. This review provides an overview of these strategies for targeting MDM2 in DDLPS.
Power Factor Angle Droop Control—A General Decentralized Control of Cascaded Inverters

This letter proposes a general decentralized control of single phase cascaded inverters-power factor angle droop control. Compared to the existing control strategies, it has the following attractive benefits: 1) it is suitable for both grid-connected and islanded modes; 2) Seamless transition between different modes can be obtained; 3) stability condition in the grid-connected mode is independent of the transmission line impedance; 4) it is suited for any types of loads in islanded modes; 5) multi-equilibrium point problem is avoided; 6) it is suitable for four quadrant operation of inverters. The small signal stability of the control is proved.
Effect of Irrigation Techniques and Quantities on Kalamata Olive Trees under North Sinai Conditions

This study was carried out during three successive seasons, (2013, 2014 and 2015) in a private orchard located in North Sinai governorate, Egypt. The study was conducted on 10 years old Kalamata olive trees planted at 6 X 6 m apart grown in sandy soil, under drip irrigation system and uniform in shape and received the common horticultural practices. The aim of this study was conducted to evaluate Kalamata olive trees irrigation techniques which involve two types (whole root-zone irrigation – alternate partial root-zone irrigation) and three levels of regulated deficit irrigation values based on crop evapotranspiration (irrigated with 100%, 80% and 60% of ETc). The obtained results indicate that alternate partial root-zone irrigation increased vegetative growth, number of inflorescences per shoot, number of perfect flowers, crop yield, fruit oil content and fruit quality characteristics as compared with whole root-zone irrigation technique. On the other hand, the previous parameters recorded strong correlation with the highest level of irrigation treatments (100% ETc control treatment) while, regulated deficit irrigation with 60% of ETc recorded the lowest values in these respect while 80% ETc treatment came in between. In general alternate partial root-zone irrigation technique saved at least 20% of irrigation water as compared with whole root-zone irrigation and improving water use efficiency.