Miracle-dz/UniFAR-FTUs huggingface dataset:
Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice.

RATIONALE Aerobic conditioning improves exercise capacity and decreases symptoms in patients with asthma. However, its benefits in the context of allergic airway inflammation are poorly understood. OBJECTIVES To evaluate the effects of two intensities of aerobic exercise on airway inflammation and remodeling in a model of chronic allergic lung inflammation. METHODS Mice were subjected to chronic ovalbumin (OVA) sensitization and to 4 weeks of low (OVA+Low) or moderate (OVA+Mod) exercise training in a treadmill. Airway inflammation and remodeling and expression of helper T-cell type 1 and 2 cytokines were evaluated. MEASUREMENTS AND MAIN RESULTS OVA-induced allergic airway inflammation and remodeling were characterized by an increase in collagen (288%), elastic fiber (56%), smooth muscle (380%), and epithelial (402%) contents (P < 0.001) when compared with the control group. OVA+Low and OVA+Mod groups presented a decrease in bronchoalveolar lavage fluid eosinophils (respectively, 84 and 75%; P < 0.01) and airway walls (respectively, 94 and 58%; P < 0.001) when compared with the OVA group. OVA+Low and OVA+Mod groups also presented a reduction in the number of peribronchial inflammatory cells expressing IL-4 (respectively, 85 and 75%; P < 0.01) and IL-5 (respectively, 88 and 89%; P < 0.01) when compared with the OVA group. Aerobic conditioning did not change the expression of either IFN-gamma or IL-2 by inflammatory cells or plasma levels of IgE or IgG1. OVA+Low and OVA+Mod groups presented an increase in the expression of IL-10 (P < 0.001). Low and moderate aerobic conditioning also reduced airway remodeling in OVA-sensitized mice when compared with the OVA group. CONCLUSIONS We concluded that low and moderate aerobic exercise decreases airway inflammation and remodeling in a murine model of asthma.
Responsiveness of Cerebral Osmoreceptors in the Anesthetized Dog

Abstract Experiments were carried out to determine if, in the anesthetized dog undergoing a water diuresis, selective elevation of cerebral osmolality induced an antidiuresis. Bilateral intracarotid infusion of hypertonic sodium chloride in an amount previously shown to increase jugular plasma osmolality by 3% was associated with a significant decline in C H2O. The same volume of hypertonic sodium chloride infused intravenously did not alter C H2O significantly. These experiments do not support the view that anesthesia blocks the response of cerebral osmoreceptors.
A RETROSPECTIVE STUDY OF PRESENTATION, TREATMENT, AND OUTCOME OF FREE-RANGING RAPTORS IN GREECE (1997–2000)

Abstract A retrospective study was conducted on free-ranging raptors (n = 402) presented to the Veterinary Medical Teaching Hospital, School of Veterinary Medicine, Aristotle University of Thessaloniki, Greece, during a 3-yr period (1997–2000). Representatives of 19 species were admitted from taxonomic orders Accipitriformes (n = 295), Falconiformes (n = 35), and Strigiformes (n = 72). Traumatic injuries (n = 305, 75.8%) were the most common cause of presentation in all raptors. Starvation (n = 38 birds, 9.4%) was the second most common reason, whereas toxicoses (n = 28, 6.9%) were suspected in a limited number of birds. Orphans (n = 31, 7.7%) were presented during breeding season primarily because of inappropriate human intervention. Surgical and medical treatment was given to all birds when necessary. In total, 229 (56.9%) of the presented raptors were successfully rehabilitated and released, 121 (30%) were rehabilitated but nonreleasable, whereas 52 (12.9%) of them died despite treatment. Human intervention (79.2%) plays the most important role in birds of prey morbidity and mortality.
Physical activity levels and energy expenditure in urban Serbian adolescents--a preliminary study.

INTRODUCTION The aim of this study was to evaluate the level of PA and EE in Serbian urban adolescents, using an objective measure. In particular, we explored gender and weight status related differences in PA level and EE among Serbian adolescents. In addition, their PA and EE obtained during schooldays and weekends were compared. METHODS From the representative sample of elementary schools in Belgrade, one school was selected by random sampling for the purpose of the objective PA assessment. The sample included 115 students (53 boys and 62 girls) of the average age 14.0 (0.6) years. EE and the duration of PA levels were assessed by the Sense Wear PRO3 Armband device (Body Media Inc., Pittsburgh, PA, USA). IOTF cut-off points were used to define subjects as non-overweight, overweight or obese. Analysis of variance was applied to examine the impacts of gender and weight status on EE and PA duration. RESULTS Adolescents spent most of the time in sedentary regime 241.7 ± 62.8 min/day, on average and they were totally physically active for 196.0 ± 73.5 min/day. Boys accumulated more PA than girls and during schooldays, the PA of all adolescents was higher than during weekend days. OW girls spent less time in total PA, MPA, and VVPA. On the other hand, NW and OW boys differed only in VVPA. Consequently, OW girls had lower energy expenditure compared with their NW peers, but no such differences in boys were found. DISCUSSION The results of this study indicate that low PA activity might be a more important factor in propagation of overweight in girls than boys, at least in early adolescent period. PA in girls should be strongly encouraged, with a special focus on vigorous PA during weekends.
Chirp-modulated visual evoked potential as a generalization of steady state visual evoked potential

Visual evoked potentials (VEPs) are of great concern in cognitive and clinical neuroscience as well as in the recent research field of brain–computer interfaces (BCIs). In this study, a chirp-modulated stimulation was employed to serve as a novel type of visual stimulus. Based on our empirical study, the chirp stimuli visual evoked potential (Chirp-VEP) preserved frequency features of the chirp stimulus analogous to the steady state evoked potential (SSVEP), and therefore it can be regarded as a generalization of SSVEP. Specifically, we first investigated the characteristics of the Chirp-VEP in the time–frequency domain and the fractional domain via fractional Fourier transform. We also proposed a group delay technique to derive the apparent latency from Chirp-VEP. Results on EEG data showed that our approach outperformed the traditional SSVEP-based method in efficiency and ease of apparent latency estimation. For the recruited six subjects, the average apparent latencies ranged from 100 to 130 ms. Finally, we implemented a BCI system with six targets to validate the feasibility of Chirp-VEP as a potential candidate in the field of BCIs.
Dampak Indikator Rasio Keuangan terhadap Profitabilitas Bank Umum Syariah di Indonesia

This study aims to determine: the bank’s performance in terms of aspects of risk profile, earnings, and capital in Islamic Banks in Indonesia in 2012-2014. This research used a descriptive quantitative method. This paper is using eleven Islamic Banks in Indonesia since the year 2012 until 2014 as samples. Risks are measured by credit risk (financing), liquidity risk is proxied by FDR, while asset quality is proxied by the NPF, company size (Size) measured by Total Assets, measured by ROA profitability analysis, efficiency analysis is measured by ROA and NIM (NOM), while Capital is measured by CAR, financial reporting data used in this study includes data on the FDR, ROA. NPF, SIZE, CAR, NOM, and ROA, these data indicate a relationship with the financial ratio indicators Profitability in Islamic Banks. Based on the analysis and interpretation of data that has been done, it can be concluded that FDR, NPF, BOPO have a positive effect to ROA, while Size has no significant effect to return on Asset at Sharia Commercial Bank, Assets of sharia banks in Indonesia is relatively small which is less than 5 trillion, which is included in the category of book 1 and book 2, so the size of the bank does not affect the profitability of sharia banks in Indonesia
Analysis of Indonesian Marketplace Based on Customer Satisfaction, Trust and Loyalty

Indonesian people are starting to realize to make the internet one of their sources of income such as making sales in the marketplace. The public's interest in using e-commerce can be seen from the number of local and international companies trying to dominate the online market in Indonesia. Online shopping transactions in the marketplace are new experiences for people in Indonesia. The success of a marketplace can be measured based on the number of visitors and transaction volume that occurs in the marketplace. Marketplace that customers often make repeated purchases will increase the marketplace revenue. The repurchase is the main goal of the marketplace company. Many marketplace companies compete to provide the best to their customers by continuing to improve system quality, information quality, and service quality. This study aims to determine the satisfaction, trust and Loyalty factors of Marketplaces in Indonesia. This study uses the Structural Equation Modeling (SEM) model to examine 12 hypotheses in the study. The results of the study show that all of these hypotheses are accepted.
Developmental Switch in Spike Timing-Dependent Plasticity and Cannabinoid-Dependent Reorganization of the Thalamocortical Projection in the Barrel Cortex

The formation and refinement of thalamocortical axons (TCAs) is an activity-dependent process (Katz and Shatz, 1996), but its mechanism and nature of activity are elusive. We studied the role of spike timing-dependent plasticity (STDP) in TCA formation and refinement in mice. At birth (postnatal day 0, P0), TCAs invade the cortical plate, from which layers 4 (L4) and L2/3 differentiate at P3-P4. A portion of TCAs transiently reach toward the pia surface around P2-P4 (Senft and Woolsey, 1991; Rebsam et al., 2002) but are eventually confined below the border between L2/3 and L4. We previously showed that L4-L2/3 synapses exhibit STDP with only potentiation (timing-dependent long-term potentiation [t-LTP]) during synapse formation, then switch to a Hebbian form of STDP. Here we show that TCA-cortical plate synapses exhibit robust t-LTP in neonates, whose magnitude decreased gradually after P4-P5. After L2/3 is differentiated, TCA-L2/3 gradually switched to STDP with only depression (t-LTD) after P7-P8, whereas TCA-L4 lost STDP. t-LTP was dependent on NMDA receptor and PKA, whereas t-LTD was mediated by Type 1 cannabinoid receptors (CB1Rs) probably located at TCA terminals, revealed by global and cortical excitatory cell-specific knock-out of CB1R. Moreover, we found that administration of CB1R agonists, including Δ9-tetrahydrocannabinol, caused substantial retraction of TCAs. Consistent with this, individual thalamocortical axons exuberantly innervated L2/3 at P12 in CB1R knock-outs, indicating that endogenous cannabinoid signaling shapes TCA projection. These results suggest that the developmental switch in STDP and associated appearance of CB1R play important roles in the formation and refinement of TCAs. SIGNIFICANCE STATEMENT It has been shown that neural activity is required for initial synapse formation of thalamocortical axons with cortical cells, but precisely what sort of activities in presynaptic and postsynaptic cells are required is not yet clear. In addition, how activity is further translated into structural changes is unclear. We show here that the period during which spike timing-dependent long-term potentiation and depression (t-LTP, t-LTD) can be induced closely matches the time course of synapse formation and retraction, respectively, at the thalamocortical synapse. Moreover, administration of cannabinoid agonists, which mimic t-LTD, caused TCA retraction, suggesting that cannabinoids translate physiological changes into morphological consequences.
An ultrastructural study of germ plasm in spermatogenesis of Xenopus laevis.

Spermatogonia and primary diplotene and zygotene spermatocytes contain an electrondense, finely granular substance which is usually closely associated with mitochondria; small patches of this substance also occur close to the nuclear membrane, often in the nuclear pores, and within the nucleus of primary spermatogonia. The fine structure of this substance is very similar to the fine structure of germ plasm in other stages of development, and since an ontogenetic continuity with germ plasm can be demonstrated, it was concluded that this substance is also germ plasm. The substance disappears about pachytene, earlier than in oogenesis where it persists until mid-diplotene, a difference which may be due to the fact that the oocyte stores large quantities of germ plasm in its cortex for the next generation of primordial germ cells. If the presence of the substance in the nuclear pores and within the nucleus is an indicator of synthesis of germ plasm, then synthesis stops in the secondary spermatogonium, which correlates with the subsequent absence of germ plasm from the pachytene spermatocyte stages. It is suggested that the function of the germ plasm in specifying germ line cells is carried out between the gastrula stage and the beginning of meiosis. The three events which take place during this period are (i) the migration of the presumptive primordial germ cells from the endoderm to the genital ridges, (ii) mitosis of the primordial germ cells and subsequently of the oogonia and spermatogonia in the developing gonads and (iii) preparations for meiosis. It is suggested that the mechanism of action of the germ plasm may be in the control of one or more of these processes. Other types of granular cytoplasmic deposits are also described, and their possible relationship to germ plasm discussed.
Factors affecting YouTube influencer marketing credibility: a heuristic-systematic model

ABSTRACT The rise of influencer marketing makes YouTube an ideal media platform to implement such marketing strategies. Many scholars consider the success of YouTube influencer marketing as a result of high consumer perception of information credibility. This study employs heuristic-systematic model to investigate how informational cues influence credibility evaluations of information posted by YouTube influencers. An online survey was conducted to investigate the factors, and a two-step, structural equation modelling data analysis approach was utilised to explore the correlation between variables. The results reveal that trustworthiness, social influence, argument quality, and information involvement are influential factors affecting consumer perceived information credibility on YouTube. The analytic results also reveal a strong and positive correlation between perceived information credibility and brand/video attitudes.
A Schematic View of Government as a Regulator and Insurer of the Financial System

The purpose of this paper is to present a schematic of the interactions between the government as the REGULATOR of financial institutions and the government as the INSURER of financial institutions while considering the long-term feedback relationships between the size and the scope of the financial sector and the level of public debt resulting from financial crises over time. The analysis concludes that at certain high level of public debt and size of the expected support of the financial sector by the government, the regulator and/or the central bank may have to “stabilize” the situation, but there may be cases where the support becomes socially “unacceptable”.
Charged Residues in Transmembrane Domains II and XI of a Vesicular Monoamine Transporter Form a Charge Pair That Promotes High Affinity Substrate Recognition*

Vesicular monoamine transporters package monoamine neurotransmitters into secretory vesicles for regulated exocytotic release. Both vesicular monoamine transporter 1 and 2 contain several charged residues predicted to reside within transmembrane domains (TMDs), and conservation of these residues in multiple species and in other members of the gene family suggest important roles in transporter structure and function. To determine the role of these residues, we have used site-directed mutagenesis. Replacement of Asp-263 in TMD6 with Asn (D263N) had no effect on transport activity. However, replacement of Lys-139 in TMD2 with Ala (K139A), Asp-400 in TMD10 with Asn (D400N), or Asp-427 in TMD11 with Asn (D427N) eliminated transport activity despite normal levels of protein expression. Remarkably, the double mutant K139A/D427N showed substantial transport activity, suggesting that Lys-139 and Asp-427 interact to form an ion pair in the native protein and hence that TMD2 occurs next to TMD11. Nonetheless, the double mutant showed reduced apparent affinity for serotonin and reduced ability of serotonin to inhibit reserpine binding, suggesting that although not required for activity, the ion pair promotes high affinity interaction with the substrate. In addition, a double mutant in which the polarity of the charged residues was reversed (K139D/D427K) showed no active transport. Remarkably, however, this mutant displayed normal reserpine binding that remained coupled to ΔH+, but serotonin failed to inhibit reserpine binding, suggesting that the charge reversal specifically disrupts substrate recognition.
Shorting in Broad Daylight: Short Sales and Venue Choice

Using a novel database on venue short sales and market design characteristics, we ask: Where do short sellers exploit their information advantage? Consistent with the prediction of Zhu (2014), we find that exchange short sales comprise a larger proportion of trading and are more informative about future prices than dark-pool short sales, particularly when there is greater competition among short sellers to trade and in the presence of short-lived information. When examining market design characteristics, we find that dark pools offering volume-weighted average price crossing attract more short sales, whereas those offering block trading attract fewer short sales.
A comparative analysis of dimensions of COO and animosity on industrial buyers’ attitudes and intentions

Purpose Country of origin (COO) is well established as an extrinsic product cue that influences buyer behavior in the business-to-business (B2B) context. However, non-product-specific attitudes to a COO, including the notion of animosity, have received rather less attention. This paper aims to investigate COO as a multi-dimensional construct and animosity as a normative dimension of buyers’ attitudes and intentions. Design/methodology/approach The work is based on data collected from industrial buyers in Egypt and Canada to enable a comparative perspective between developing and developed countries. Structural equation modeling was used to test the study’s hypotheses. Findings Country of manufacture was an antecedent of perceived quality and a determinant of brand evaluation in both countries. Price was an antecedent of perceived risk and value in Egypt, while its impact on perceived risk was less pronounced in Canada. Perceived value was the strongest determinant of willingness to buy, while animosity played a significant role in this respect in Canada but not in Egypt. Research limitations/implications Country of brand was not included as a dimension to be investigated; industry type was not controlled and may confound the results; and generalization of the results is limited given the cross-sectional approach. Originality/value The study’s contribution lies in four main elements, viewed individually and in combination: investigating a large number of COO constructs that have not been studied within a single research context in B2B before; including the animosity construct in a B2B setting; contrasting “benefit received” and “sacrifice given” constructs that help to shape industrial buyers’ purchase decisions; and carrying out the research in two very different countries to help improve the generalizability of results.
The experimental use of antisense oligonucleotides: a guide for the perplexed.

Antisense oligonucleotide biotechnology, at least in theory, provides a specific, rapid, and potentially high-throughput method for inhibiting gene expression and exploring gene function. Over the past decade, a plethora of experiments has been submitted, and a lesser number published, employing this approach to inhibiting gene expression at the mRNA level. The specificity of the antisense approach stems, of course, from the specificity (or, the “information content”) of the Watson-Crick base pair interaction. The fact that antisense oligonucleotides carry significant information in addition to that denoted by their nucleotide sequences is frequently overlooked. This oversight has frequently led to the lack of rigorous controls for many antisense experiments, and, on all too many occasions, to the inappropriate interpretation of experimental data (1). Indeed, serious questions have arisen as to whether an observed biological effect in an antisense experiment has indeed been produced by an antisense mechanism, or whether it is due to a complex combination of non–sequence specific effects. Investigators must therefore understand how to employ antisense technology properly and should recognize its limitations.
Regulation of polar morphogenesis in Caulobacter crescentus

Deoxyribonucleic acid (DNA) phage phi CbK-resistant nonmotile mutants of Caulobacter crescentus CB15 were examined for their formation of polar surface structures (a stalk, a single flagellum, pili, and DNA phage receptors). These mutants were devoid of pili and DNA phage receptors and simultaneously defective either in both stalk formation and flagellar activity (stalk-defective type) or in the formation of normal flagella (flagella-defective type). DNA phage phi Cr30-mediated transductions revealed that stalk-defective mutants were of a single genetic type, whereas flagella-defective mutants were grouped into two different genetic types, I and II. To investigate how membrane proteins change in the above morphology mutants, cell envelopes pulse-labeled with L-[35S]methionine were analyzed by two-dimensional gel electrophoresis. No gross change of membrane proteins was observed in the stalk-defective mutant CB15 pdr-803, except a 49,000-molecular-weight (49K) protein which was found reduced. However, a 27K, two 28.5K, and a 70.5K protein were missing from the membrane of the flagella-defective type I mutant CB15 pdr-813. These proteins are most likely to be flagella-related protein, flagellins A and B, and hook protein, respectively. In another flagella-defective type II mutant, CB15 pdr-816, the 27K and two 28.5K proteins were similarly absent but the 70.5K protein was consistently present in the membrane. The synthesis of flagellin was next assayed radioimmunologically in the above 35S-labeled mutants. Stalk-defective CB15 pdr-803 synthesized flagellin normally, compared to the wild-type strain. Flagellins A (26K) and B (28K) formed multiple spots in isoelectric focusing. A 29K protein was also detected in the flagellin-specific radioactivity from the cytoplasm. Flagella-defective type I CB15 pdr-813 synthesized flagellin only at a basal level. Thus transcription or translation of flagellin appeared to be repressed in this mutant. Another flagella-defective type II strain, CB15 pdr-816, however, synthesized flagellin at an apparently enhanced rate compared with the wild type. Flagellin synthesized in CB15 pdr-816 was flagellin A and a smaller 22K flagellin. Flagellin B was not synthesized in the mutant. It then follows that flagellin B is not a precursor of flagellin A and the 22K flagellin. Flagella-defective type II CB15 pdr-816, without flagellin B, formed a stub structure with a hook attached to one end instead of normal flagella. In the wild-type membrane, flagellin B was the major flagellin, whereas flagellin A was major in the cytoplasm and the flagellar filament. It is suggested from these results that flagellin B is important in the assembly of normal flagella.