Miracle-dz/UniFAR-FTUs huggingface dataset:
Acceleration of image-based resolution modelling reconstruction using an expectation maximization nested algorithm

Recent studies have demonstrated the benefits of a resolution model within iterative reconstruction algorithms in an attempt to account for effects that degrade the spatial resolution of the reconstructed images. However, these algorithms suffer from slower convergence rates, compared to algorithms where no resolution model is used, due to the additional need to solve an image deconvolution problem. In this paper, a recently proposed algorithm, which decouples the tomographic and image deconvolution problems within an image-based expectation maximization (EM) framework, was evaluated. This separation is convenient, because more computational effort can be placed on the image deconvolution problem and therefore accelerate convergence. Since the computational cost of solving the image deconvolution problem is relatively small, multiple image-based EM iterations do not significantly increase the overall reconstruction time. The proposed algorithm was evaluated using 2D simulations, as well as measured 3D data acquired on the high-resolution research tomograph. Results showed that bias reduction can be accelerated by interleaving multiple iterations of the image-based EM algorithm solving the resolution model problem, with a single EM iteration solving the tomographic problem. Significant improvements were observed particularly for voxels that were located on the boundaries between regions of high contrast within the object being imaged and for small regions of interest, where resolution recovery is usually more challenging. Minor differences were observed using the proposed nested algorithm, compared to the single iteration normally performed, when an optimal number of iterations are performed for each algorithm. However, using the proposed nested approach convergence is significantly accelerated enabling reconstruction using far fewer tomographic iterations (up to 70% fewer iterations for small regions). Nevertheless, the optimal number of nested image-based EM iterations is hard to be defined and it should be selected according to the given application.
An extended UTAUT model for understanding of the effect of trust on users' acceptance of cloud computing

In this paper, we propose an extended Unified Theory of Acceptance and Use of Technology (UTAUT) model with trust to investigate the effect of trust on users' behavioural intention to use cloud computing. Structural Equation Modelling (SEM) was used to analyse the collected data and to assess the proposed model. The results indicated that trust, performance expectancy and facilitating conditions have significant effects on behavioural intention to use cloud computing. However, we also found that effort expectancy and social influence do not significantly affect users' behavioural intention to use cloud computing. In addition, the five constructs (effort expectancy, performance expectancy, social influence, facilitating conditions and trust) accounted for 70% of the variance in the attitude toward adopting cloud computing. The paper concludes with the limitations of the study, implications for academic research and practical institutions and some directions for future work.
Why Superman Can Wait: Cognitive Self-Transformation in the Delay of Gratification Paradigm

We examined middle-class Israeli preschoolers’ cognitive self-transformation in the delay of gratification paradigm. In Study 1, 66 un-caped or Superman-caped preschoolers delayed gratification, half with instructions regarding Superman's delay-relevant qualities. Caped children delayed longer, especially when instructed regarding Superman's qualities. In Study 2 with 43 preschoolers, with the respective relevant superhero qualities emphasized (i.e., patient vs. impulsive), Superman-caped children tended to delay longer than Dash-caped children. In Study 3, 48 preschoolers delayed gratification after being instructed to pretend to be Superman or a child with the same patient qualities, or after watching a video of Superman, with or without pretend instructions. Invoking Superman led to longer delays and instructions regarding Superman's qualities tended to lead to longer delays than watching the Superman video. In accounting for the data, we differentiated cognitive transformations of the reward's consummatory value and cognitive transformations as basic intellectual processes.
Concentration-Dependent Selection of Small Phenotypic Differences in TEM β-Lactamase-Mediated Antibiotic Resistance

ABSTRACT In this paper, the first robust experimental evidence of in vitro and in vivo concentration-dependent selection of low-level antibiotic-resistant genetic variants is described. The work is based on the study of an asymmetric competition assay with pairs of isogenicEscherichia coli strains, differing only (apart from a neutral chromosomal marker) in a single amino acid replacement in a plasmid-mediated TEM-1 beta-lactamase enzyme, which results in the new TEM-12 beta-lactamase. The mixture was challenged by different antibiotic concentrations, both in vitro and in the animal model, and the selective process of the variant population was carefully monitored. A mathematical model was constructed to test the hypothesis that measured growth and killing rates of the individual TEM variants at different antibiotic concentrations could be used to predict quantitatively the strength of selection for TEM-12 observed in competition experiments at these different concentrations.
Brain activity in bilingual developmental dyslexia: An fMRI study

The aim of this study was to identify the neural substrates of an adult English-German bilingual with dyslexia (in both languages) during lexical decision-making using functional magnetic resonance imaging (fMRI). A lexical decision task with five conditions in a block design was employed (nonverbal shape judgment, lettercase judgment, regular word judgment, irregular word judgment, and nonword judgment), and the activation was compared to a non-dyslexic control bilingual and a control monolingual participant. Both of the control participants matched the dyslexic bilingual BK on age, sex, IQ, handedness, and education level. Results indicated that the bilingual adult with dyslexia was strongly right lateralized for stimuli that required phonological processing, a profile that differed particularly from the activation observed from the monolingual participant. These results are consistent with the idea of increased activation (mostly in the right hemisphere) during linguistic tasks in adults with dyslexia and in late proficient bilinguals relative to monolinguals. Findings also suggest that the additional activation observed in both of the bilinguals are similar, suggesting that these effects are not additive in the dyslexic bilingual.
SOLVABILITY OF SECOND-ORDER BOUNDARY-VALUE PROBLEMS AT RESONANCE INVOLVING INTEGRAL CONDITIONS

This article concerns the second-order differential equation with integral boundary conditions x′′(t) = f(t, x(t), x′(t)), t ∈ (0, 1), x(0) = Z 1 0 x(s)dα(s), x(1) = Z 1 0 x(s)dβ(s). Under the resonance conditions, we construct a projector and then applying coincidence degree theory to establish the existence of solutions.
Fibroxanthosarcoma of the soft tissues. A type of malignant fibrous histiocytoma

The clinical and pathologic features of 30 soft tissue tumors which have a storiform fibrous stroma and bizarre histiocytes and giant cells are reviewed. Because of the resemblance of these lesions to the fibrous histiocytomas and because three of the tumors metastasized, they have been designated as fibroxanthosarcomas. Local recurrence was also common. Fibroxanthosarcoma occurs in many areas of the soft tissues but most commonly in the extremities. Histologically, it resembles storiform fibrous xanthoma (dermatofibrosarcoma protuberans) but can be separated from this entity by the presence of anaplastic bizarre giant cells and numerous mitoses. A proposed nomenclature for the fibrous histiocytomas is also presented. It is concluded that fibroxanthosarcoma is a distinctive malignant fibrous histiocytoma with a bizarre histologic pattern which can be distinguished from other soft tissue sarcomas and from the other fibrous histiocytomas.
Central pacific El Niño, the "subtropical bridge," and Eurasian climate

[1] This study contributes to the discussion on possible effects of El Nino on North Atlantic/European regional climates. We use NCEP/NCAR reanalysis data to show how the two different types of El Ninos (the central Pacific, or CP, and the east Pacific, or EP) result in remarkably different European winter temperature anomalies, specifically weak warming during EP and significant cooling during CP El Ninos, the latter being associated with a negative phase of the winter North Atlantic Oscillation (NAO). Our results diverge from former suggestions addressing the weakened stratospheric polar vortex as the dominant factor contributing to the El Nino/NAO teleconnection. We propose a tropospheric bridge as the mechanism primarily responsible for the establishment of a negative NAO phase and of associated cold European winters. This mechanism includes the subtropical jet (STJ) waveguide being activated only during CP El Ninos, when anomalous convective heating occurs near the edge of the Pacific warm pool. Under these conditions the STJ is enhanced by planetary wave flux divergence in the subtropical upper troposphere, providing favorable conditions for the propagation of a wave number 5 disturbance around the subtropical Northern Hemisphere. This wave contributes to weakening of the Azores High and, hence, to the negative NAO phase. As global warming scenarios project an increase in the frequency of CP El Nino events, the distinctive nature of this mechanism implies that the probability of cold European winters may increase as well in future decades.
The lncRNA PCAT29 Inhibits Oncogenic Phenotypes in Prostate Cancer

Long noncoding RNAs (lncRNA) have recently been associated with the development and progression of a variety of human cancers. However, to date, the interplay between known oncogenic or tumor-suppressive events and lncRNAs has not been well described. Here, the novel lncRNA, prostate cancer–associated transcript 29 (PCAT29), is characterized along with its relationship to the androgen receptor. PCAT29 is suppressed by DHT and upregulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increased proliferation and migration of prostate cancer cells, whereas PCAT29 overexpression conferred the opposite effect and suppressed growth and metastases of prostate tumors in chick chorioallantoic membrane assays. Finally, in prostate cancer patient specimens, low PCAT29 expression correlated with poor prognostic outcomes. Taken together, these data expose PCAT29 as an androgen-regulated tumor suppressor in prostate cancer. Implications: This study identifies PCAT29 as the first androgen receptor–repressed lncRNA that functions as a tumor suppressor and that its loss may identify a subset of patients at higher risk for disease recurrence. Visual Overview: http://mcr.aacrjournals. org/content/early/2014/07/31/1541-7786.MCR-14-0257/F1.large. jpg. Mol Cancer Res; 12(8); 1081–7. ©2014 AACR. Visual Overview
A meta-analysis of hypnotically induced analgesia: How effective is hypnosis?

Abstract Over the past two decades, hypnoanalgesia has been widely studied; however, no systematic attempts have been made to determine the average size of hypnoanalgesic effects or establish the generalizability of these effects from the laboratory to the clinic. This study examines the effectiveness of hypnosis in pain management, compares studies that evaluated hypnotic pain reduction in healthy volunteers vs. those using patient samples, compares hypnoanalgesic effects and participants' hypnotic suggestibility, and determines the effectiveness of hypnotic suggestion for pain relief relative to other nonhypnotic psychological interventions. Meta-analysis of 18 studies revealed a moderate to large hypnoanalgesic effect, supporting the efficacy of hypnotic techniques for pain management. The results also indicated that hypnotic suggestion was equally effective in reducing both clinical and experimental pain. The overall results suggest broader application of hypnoanalgesic techniques with pain patients.
Modification of Innervation Pattern by Fluoroquinolone Treatment in the Rat Salivary Glands

Fluoroquinolone antibiotics (FQAs) are widely used in dental and medical therapy. Despite their known severe adverse actions on the central and peripheral nervous system, little attention has been directed toward the potential toxic side effects of these compounds on the oral tissues. As the saliva secretion is controlled by the nervous system and neuropeptides, the neurotoxic effect of pefloxacin (PEF), a representative member of FQAs, was studied in rats in the present work. Previously, we demonstrated a significant weight loss of parotid gland tissue, a marked decrease in 3H‐thymidine incorporation, a decreased volume of saliva and amylase activity of the glandular tissue in response to PEF. Animals received intraperitoneal injection of PEF (20 mg/100 g body weight daily) for 3 and 7 days. Normal histology, and neurofilament 200, substance P (SP) and calcitonin gene‐related polypeptide (CGRP) containing nerve fibers were detected with immunohistochemical methods. A marked decrease of the weights in salivary glands and the acinar diameters were measured. Similarly, a strong and significant decrease of the number of SP and CGRP containing nerve fibers were detected. These findings suggest that the impaired morphology and innervation pattern of salivary glands is related to the neurotoxic adverse effect of FQA treatment. Anat Rec, 2010. © 2009 Wiley‐Liss, Inc.
Examination of the Two Types of ENSO in the NCEP CFS Model and Its Extratropical Associations

AbstractTwo types of El Nino–Southern Oscillation (ENSO) simulated by the National Centers for Environmental Prediction (NCEP) Climate Forecast System (CFS) model are examined. The model is found to produce both the eastern Pacific (EP) and central Pacific (CP) types of ENSO with spatial patterns and temporal evolutions similar to the observed. The simulated ENSO intensity is comparable to the observed for the EP type, but weaker than the observed for the CP type. Further analyses reveal that the generation of the simulated CP ENSO is linked to extratropical forcing associated with the North Pacific Oscillation (NPO) and that the model is capable of simulating the coupled air–sea processes in the subtropical Pacific that slowly spreads the NPO-induced SST variability into the tropics, as shown in the observations. The simulated NPO, however, does not extend as far into the deep tropics as it does in the observations and the coupling in the model is not sustained as long as it is in the observations. As a .
A Case of Clinical Indolent Natural Killer Cell Lineage Large Granular Lymphocytic Leukemia in a Patient with Rheumatoid Arthritis

We report a case of natural killer (NK) cell leukemia with unusual biological features in a 65-year-old woman with a 20-year history of rheumatoid arthritis. She presented with neutropenia, thrombocytopenia, splenomegaly and bone marrow infiltration. Immunophenotyping (CD2+ CD3- CD4- CD5- CD8- CD16+ CD56-) confirmed NK cell leukemia. Her neutropenia and thrombocytopenia resolved following splenectomy and she has remained well with stable disease for 12 months on oral low-dose methotrexate. In contrast to all previous reports, in this instance the phenotype of large granular lymphocytic (LGL) leukemia occurring in the context of rheumatoid arthritis was NK-cell rather than T-cell. Furthermore, the clinical course was indolent, whereas, all prior literature reports have described a very aggressive clinical course for this disorder with a median survival of just 3.5 months. This case illustrates previously unrecognized heterogeneity in the natural history of this disorder.
Efficient Resource Utilization in Virtual Cloud Computing Environment

Cloud computing is a platform that provides user to implement revolutionary technologies. The main phenomena of cloud computing is based on accessing the resources using remote computation. Task scheduling is one of the major area that should be focused on. In cloud environment there may be a condition where the resources are limited that may affect resource availability. This paper presents an Enhanced version of MaxMin task scheduling algorithm that improves the turnaround time. The tasks are divided in two groups and the larger task is assigned to the resource (virtual machine) with high mips rate and other task is assigned to resource with low mips rate. To perform the experiment CloudSim toolkit is used. Our result shows that the Enhanced MaxMin algorithm gives the better result.
In vivo effects of a recombinant vaccinia virus expressing a mouse mammary tumor virus superantigen

Early after infection, the mouse mammary tumor virus (MMTV) expresses a superantigen (SAg) at the surface of B lymphocytes. Interaction with the T-cell receptor Vbeta domain induces a polyclonal proliferative response of the SAg-reactive T cells. Stimulated T cells become anergic and are deleted from the T-cell repertoire. We have used a recombinant vaccinia virus encoding the MMTV(GR) SAg to dissect the effects of the retroviral SAg during an unrelated viral infection. Subcutaneous infection with this recombinant vaccinia virus induces a very rapid increase of Vbeta14 T cells in the draining lymph node. This stimulation does not require a large Plumber of infectious particles and is not strictly dependent on the expression of the major histocompatibility complex class II I-E molecule, as it is required after MMTV(GR) infection. In contrast to MMTV infection during which B cells are infected, we do not observe any clonal deletion of the reactive T cells following the initial stimulation phase. Our data show that contrary to the case with MMTV, macrophages but not B cells are the targets of infection by vaccinia virus in the lymph node, indicating the ability of these cells to present a retroviral SAg. The altered SAg expression in a different target cell observed during recombinant vaccinia virus infection therefore results in significant changes in the SAg response.
Progression of an Orbital T-cell Rich B-cell Lymphoma to a B-cell Lymphoma in a Dog

An 11-year-old Shetland Sheepdog was presented for exophthalmos caused by a locally extensive, poorly defined mass located behind the right eye. The primary orbital mass was identified by light microscopy and immunohistochemistry as a T-cell rich B-cell lymphoma (TCRBCL) composed predominantly of BLA.36- positive large neoplastic lymphoid cells admixed with fewer CD3- and CD79a-positive small lymphocytes. The dog was treated for lymphoma, but 6 months after presentation it was euthanatized for suspected hepatic and gastrointestinal metastasis. Gross findings revealed an enlarged liver with multiple well-demarcated, randomly distributed 0.1—1.5-cm white nodules, five firm white submucosal jejunal nodules, and ileocecal, mediastinal, and hilar lymphadenopathy. Metastatic liver lesions consisted of sheets of monomorphic large neoplastic lymphoid cells that effaced and expanded portal and centrilobular zones. These cells were morphologically similar to the large neoplastic cells of the original orbital tumor and were CD3-negative and variably BLA.36-positive, consistent with B-cell lineage. Similar cells comprised the jejunal nodules and effaced the lymph nodes. The progression of TCRBCL to a diffuse B-cell lymphoma in this case is consistent with reported human cases and has not been previously reported in the dog.
Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors.

A series of aliphatic propargylamine derivatives has been synthesized. Some of them possess highly potent, irreversible, selective, inhibitory activity toward monoamine oxidase B (MAO-B). The potency of the inhibitors is related to chain length and substitution of a hydrogen on the terminal carbon of the aliphatic chain. MAO inhibitory activity as assessed in vitro increased as the aliphatic carbon chain length increased. Substitution of a hydrogen by hydroxyl, carboxyl, or carbethoxyl groups at the aliphatic chain terminal or replacement of the methyl group on the nitrogen atom by an ethyl group considerably reduced the inhibitory activity. Stereospecific effects were observed with the R-(-)-enantiomer being 20-fold more active than the S-(+)-enantiomer. Inhibitors with relatively short carbon chain lengths (i.e. four to six carbons) were found to be more potent than those with longer chains in inhibiting brain MAO-B activity in vivo especially after oral administration. Chronic administration of low doses of the aliphatic propargylamines caused a slight cumulative inhibition of MAO-A activity in the mouse brain. These MAO-B inhibitors appear to be nontoxic, and they do not possess an amphetamine-like moiety in their structure as is the case for deprenyl. We expect that these aliphatic propargylamines may be useful in the treatment in certain neuropsychiatric disorders.
Preeclampsia in the parous woman: who is at risk?

OBJECTIVE The purpose of this study was to identify risk factors for preeclampsia in second pregnancies and to determine whether gestational age at delivery in the first pregnancy increases the risk of recurrent preeclampsia. STUDY DESIGN We conducted a population-based, case-control study using birth certificate data from the Missouri maternally linked cohort. Data from women delivered of their first 2 singleton pregnancies between 1989 and 1997 (2332 cases with preeclampsia in the second pregnancy and 2370 control cases) were analyzed with logistic regression. RESULTS Significant risk factors for preeclampsia in a second pregnancy include longer birth interval, previous preterm delivery, previous small-for-gestational-age newborn, renal disease, chronic hypertension, diabetes mellitus, obesity, black race, and inadequate prenatal care. Smoking and same paternity are protective. A history of preeclampsia confers the highest risk for preeclampsia in the second pregnancy; the risk is inversely proportional to gestational age at delivery of the first pregnancy: adjusted odds ratio, 15.0; 95% CI, 6.3-35.4 for 20 to 33 weeks; adjusted odds ratio, 10.2; 95% CI, 6.2-17.0 for 33 to 36 weeks; and adjusted odds ratio, 7.9; 95% CI, 6.3-10.0 for 37 to 45 weeks. CONCLUSION The relative risk of recurrent preeclampsia increases with earlier gestational age at delivery of the first pregnancy that was complicated by preeclampsia.