Miracle-dz/UniFAR-FTUs huggingface dataset:
Weather forecast based scheduling for demand response optimization in smart grids

Demand side management is one of the most promising techniques to reduce energy losses in future electricity distribution networks. Although this topic has been addressed in literature already, the existing approaches remain on the level of mathematical and analytical models rather than deployable solutions that would actually utilize controllable demand. In this paper, we present an algorithm for scheduling water heaters' activity intervals with the purpose of balancing fluctuations of total power demand and uncontrollable photovoltaic production, and designed for real deployment. To do so, our method uses historical metering data and weather forecasts. We specify the environment the algorithm was designed for, describe predictions we did and present the steps of choosing optimal switching times.
A FIXED POINT THEOREM FOR ASYMPTOTICALLY NONEXPANSIVE MAPPINGS

Let K be a subset of a Banach space X. A mapping F.K-+KI& said to be asymptotically nonexpansive if there exists a sequence {ki} of real numbers with £? -+1 as /'-►co such that WF'x—F'yW^kiWx—yW, yE K. It is proved that if AT is a non- empty, closed, convex, and bounded subset of a uniformly convex Banach space, and if F-. K-+K is asymptotically nonexpansive, then F has a fixed point. This result generalizes a fixed point theorem for nonexpansive mappings proved independently by F. E. Browder, D. Gohde, and W. A. Kirk.
Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages*

Influenza A viruses cause infections in the human respiratory tract and give rise to annual seasonal outbreaks, as well as more rarely dreaded pandemics. Influenza A viruses become quickly resistant to the virus-directed antiviral treatments, which are the current main treatment options. A promising alternative approach is to target host cell factors that are exploited by influenza viruses. To this end, we characterized the phosphoproteome of influenza A virus infected primary human macrophages to elucidate the intracellular signaling pathways and critical host factors activated upon influenza infection. We identified 1675 phosphoproteins, 4004 phosphopeptides and 4146 nonredundant phosphosites. The phosphorylation of 1113 proteins (66%) was regulated upon infection, highlighting the importance of such global phosphoproteomic profiling in primary cells. Notably, 285 of the identified phosphorylation sites have not been previously described in publicly available phosphorylation databases, despite many published large-scale phosphoproteome studies using human and mouse cell lines. Systematic bioinformatics analysis of the phosphoproteome data indicated that the phosphorylation of proteins involved in the ubiquitin/proteasome pathway (such as TRIM22 and TRIM25) and antiviral responses (such as MAVS) changed in infected macrophages. Proteins known to play roles in small GTPase–, mitogen-activated protein kinase–, and cyclin-dependent kinase- signaling were also regulated by phosphorylation upon infection. In particular, the influenza infection had a major influence on the phosphorylation profiles of a large number of cyclin-dependent kinase substrates. Functional studies using cyclin-dependent kinase inhibitors showed that the cyclin-dependent kinase activity is required for efficient viral replication and for activation of the host antiviral responses. In addition, we show that cyclin-dependent kinase inhibitors protect IAV-infected mice from death. In conclusion, we provide the first comprehensive phosphoproteome characterization of influenza A virus infection in primary human macrophages, and provide evidence that cyclin-dependent kinases represent potential therapeutic targets for more effective treatment of influenza infections.
B-type fabric in the mantle wedgeinsights from high-resolution non-Newtonian subduction zone mode

Several hypotheses have been proposed to explain trench-parallel shear wave splitting in the mantle wedge of subduction zones. These include 3-D flow effects, parallel melt filled cracks, and B-type olivine fabric. We predict the distribution of B-type and other fabrics with high-resolution thermal and stress models of subduction zones. A composite viscous rheology is used that incorporates wet diffusion creep, wet dislocation creep, and a stress-limiting approximated Peierls creep law. Rheological parameters for dislocation and diffusion creep are based on deformation experiments. The effects of variable viscous coupling between the slab and mantle are explored using kinematic boundary conditions that change along the top of the slab. Two end-member models are observed, which depend on the depth of partial viscous coupling between the slab and mantle: (1) deep partial coupling which gives rise to cold, high-stress conditions in the fore-arc mantle and high-temperature, low-stress conditions in the arc and.back-arc mantle (2) full viscous coupling at the base of a 40 km conducting lid which is characterized by high temperature and low stress. The case with deep partial coupling, which produces a better match with attenuation tomography and heat flow, shows a large region with suitable conditions for B-type fabric in the fore-arc mantle, and a rapid transition toward the back arc to conditions that are more suitable for A, C, or E type fabrics. Full viscous coupling gives rise to high-temperature, low-stress conditions unsuitable for B-type fabric. Our modeling predicts that the best candidates for regions with B-type fabric are the fore-arc mantle and a cold 10-15 km layer above the slab.
The ATG16L1–T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients

Objective Crohn's disease (CD) is caused by a complex interplay among genetic, microbial and environmental factors. ATG16L1 is an important genetic factor involved in innate immunity, including autophagy and phagocytosis of microbial components from the gut. We investigated the effect of inflammation on the composition of microbiota in the ileal mucosa of CD patients in relation to the ATG16L1 risk status. Design Biopsies (n=35) were obtained from inflamed and non-inflamed regions of the terminal ileum of 11 CD patients homozygous for the ATG16L1 risk allele (ATG16L1-T300A) and 9 CD patients homozygous for the ATG16L1 protective allele (ATG16L1-T300). Biopsy DNA was extracted and the bacterial composition analysed by pyrosequencing. Intracellular survival rates of adherent-invasive Escherichia coli (AIEC) were analysed by determining colony forming units after exposure to monocytes isolated from healthy volunteers homozygous for the ATG16L1 risk or protective allele. Results Inflamed ileal tissue from patients homozygous for the ATG16L1 risk allele contained increased numbers of Fusobacteriaceae, whereas inflamed ileal tissue of patients homozygous for the ATG16L1 protective allele showed decreased numbers of Bacteroidaceae and Enterobacteriaceae and increased Lachnospiraceae. The ATG16L1 allele did not affect the bacterial composition in the non-inflamed ileal tissue. Monocytes homozygous for the ATG16L1 risk allele showed impaired killing of AIEC under inflammatory conditions compared with those homozygous for the ATG16L1 protective allele. Conclusions CD patients homozygous for the ATG16L1–T300A risk allele show impaired clearance of pathosymbionts in ileal inflammation indicating that ATG16L1 is essential for effective elimination of pathosymbionts upon inflammation.
Efficacy and Safety of Percutaneous Nephrolithotomy with Adult Standard Size Instruments in Children under 3 Years of Age: A 10 Years Single-Center Experience

Background Using percutaneous nephrolitotomy (PCNL) with large adult instruments in treatment of pediatricurolithiasis is still in debate. This study was conducted to evaluate the efficacy and safety of PCNL with adult's instrument in treatment of patients less than 3 years old. Methods Data on patient characteristics and outcomes for 261 consecutive children undergoing PCNL at a Labbafinejad University Hospital were collected prospectively from September 2006 to February 2016. Thirty-two children, with 34 renal units, who were treated with PCNL were enrolled in the study. All PCNL procedures were performed via subcostal approach with one access tract in all of them. Postoperative complications were evaluated according to the modified Clavien grading system. Results The mean age of patients was 19.4 ± 6.2 months. Two patients had bilateral stones; thus, PCNL was performed on 34 kidney units. The mean size of the largest stone diameter was 17.5 ± 7.8 mm. The mean duration of procedures was 121.52 ± 29.05 minutes, ranging from 60 to 180 minutes. The most common complication was fever (n = 9, 26.4%), and hemorrhage that needs transfusion was the second one (n = 4, 11.7%). Seventeen patients with complications were in the first degree of Clavien complication system and five of them were in the second degree. Conclusions Due to our experience, utilizing PCNL with adult-sized instruments in management of urolithiasis in less than 3 years old children appeared to be effective and relatively safe.
Release of Chlorpheniramine Maleate from Fatty Acid Ester Matrix Disks Prepared by Melt‐extrusion

Abstract— Chlorpheniramine maleate was incorporated into disks consisting of glyceryl fatty acid esters, polyethylene glycol fatty acid esters or a combination of the two. A melt‐extrusion process was used to prepare the matrix disks containing the drug. The release of the drug into distilled water, pH 1·2 buffer, and pH 7·5 buffer showed the expected square root of time dependence. An increase in the fatty acid ester hydrophilic‐lipophilic balance (HLB) from 1 to 14 resulted in a 10‐fold increase in the drug release rate from 0·25 ± 0·01 to 25·84 ± 1·29 mg cm−2 h−½ The maximum release rate was seen from the fatty acid ester with a melting point of 44°C. The pH of the dissolution medium had a small impact on the rate of drug release, but the rate of agitation had no significant influence on the rate of drug release. By blending a fatty acid ester of a high melting point (64°C) and a low HLB value of 2 with esters of lower melting points (33 to 50°C) or higher HLB values (10 to 14), it was possible to modify the release from 10·0 ± 0·70 to 21·5 ± 0·57 mg cm−2 h−½
To study the correlation of serum S-100 protein level with the severity of stroke and its prognostic implication

Objective: This study investigated correlation between mortality, stroke subtype and stroke severity with serum S-100 protein level prior to the treatment of the patients admitted to the emergency department and diagnosed with a stroke. Methods: Pretreatment sample were collected from the patients (n = 142) to determine S-100 protein level, age and sex-matched healthy individuals (n = 40) served as control. All patients had cranial computerized tomography scan/magnetic resonance imaging in the first 24 h. The neurological evaluation was made with the National Institute of Health Stroke Scale (NIHSS) in the acute stage. Results: Compared with controls, S-100 protein level were significantly higher in the stroke groups. In stroke groups, S-100 protein level was more significantly higher in the ischemic group than hemorrhage and transient ischemic attack group and highest in expired patients. Conclusion: Serum S-100 protein measurement can be used as an early marker of brain damage. There is a role of S-100 protein as a co-predictor of outcome in patients with acute stroke.
Will black carbon mitigation dampen aerosol indirect forcing?

If mitigation of black carbon (BC) particulate matter is accompanied by a decrease in particle number emissions, and thereby by a decrease in global cloud condensation nuclei (CCN) concentrations, a decrease in global cloud radiative forcing (a reverse “cloud albedo effect”) results. We consider two present‐day mitigation scenarios: 50% reduction of primary black carbon/organic carbon (BC/OC) mass and number emissions from fossil fuel combustion (termed HF), and 50% reduction of primary BC/OC mass and number emissions from all primary carbonaceous sources (fossil fuel, domestic biofuel, and biomass burning) (termed HC). Radiative forcing effects of these scenarios are assessed through present‐day equilibrium climate simulations. Global average top‐of‐the‐atmosphere changes in radiative forcing for the two scenarios, relative to present day conditions, are +0.13 ± 0.33 W m−2 (HF) and + 0.31 ± 0.33 W m−2 (HC).
Clinical Management of Elderly Patients with Type 2 Diabetes Mellitus

Abstract With an increase in life expectancy of the general population comes an increase in the number of elderly patients with type 2 diabetes mellitus (T2DM). Although the pharmacologic treatment options for elderly patients with T2DM are the same as for younger adults, management of this growing group poses unique challenges. Changes in renal and hepatic function and an increased prevalence of multiple comorbidities mandate an individually tailored treatment strategy that balances treatment benefits with the patient's functional status and risk for hypoglycemia and polypharmacy. This approach is hampered by the relative paucity of data regarding the pharmacotherapy of T2DM in older adults, necessitating clinical guidance based on data extrapolated from a younger population. Most current guidelines are disease–focused and do not include specific instructions on how to prioritize the treatment of hyperglycemia relative to that of other comorbidities and the functional status of patients. This article reviews the epidemiology, pathophysiology, comorbidities, pharmacokinetic considerations, treatment goals, guidelines, and treatment options for the elderly population, and highlights the current knowledge gaps complicating the management of T2DM in this population.
Diagnostic Strategies and Treatment for Ewing’s Sarcoma

Ewing’s sarcoma is an enigmatic malignancy of progenitor cell origin, driven by transcription factor oncogenic fusions. About 85% of ESFT cases harbor the t(11;22) translocation and express the fusion protein EWS-FLI. Both bone marrow-derived human Mesenchymal stem cells and Neural crest stem cells are permissive for EWS-FLI1 expression that initiates transition to ESFT-like cellular phenotype. Diagnosis of Ewing’s tumor is based on pathologic and molecular findings. The hypoxia enhances the malignancy of ESFT invasive capacity. An ALDHhigh subpopulation of Ewing’s sarcoma cells, capable of self-renewal, tumor initiation and resistant to chemotherapy in vitro, are not resistant to YK-4-279. Intensive high-dose chemotherapy followed by stem-cell reconstitution was used for ESFT patients in second remission. Plerixafor in combination with G-CSF is an effective enhance stem cell mobilization regimen for stem cell collection with lowest success rate in patients with neuroblastoma. The ESFT-derived antigens EZH2(666) and CHM1(319) are suitable targets for protective allo-restricted human CD8(+) T-cell responses against non-immunogenic ESFT. Primitive neuroectodermal features and MSC origin are both compatible with G(D2) aberrant expression and explore G(D2) immune targeting in ESFT.
De la quenelle culinaire à la quenelle politique : identification de changements sémantiques à l'aide des Topic Models

Dans cet article nous employons le \og topic modeling\fg{} pour explorer des chemins vers la detection automatique d'apparition de nouveaux sens pour des mots connus. Nous appliquons les methodes introduites dans \cite{lau_word_2012,lau_learning_2014} a un cas de neologie semantique recent, l'apparition du nouveau sens de \textit{geste} pour le mot \og quenelle\fg{}. Nos experiences mettent en evidence le potentiel de cette approche pour l'apprentissage des sens du mot, l'alignement des topics a des sens de dictionnaire et enfin la detection de nouveaux sens.
Molecular weight effects on the glass transition of gelatin/cosolute mixtures.

The structural properties of four gelatin fractions in mixture with sucrose and glucose syrup have been investigated extensively using small deformation dynamic oscillation. The total level of solids was 80%, the number average molecular weight of the protein ranged from 29.2 to 68 kD, and the temperatures were between 60 and -60 degrees C. Remarkably, the nature of the time and temperature dependence on the viscoelastic functions of all samples could be reduced to master curves using horizontal shift factors. The construction of master curves indicates a common mechanism of structure formation, which, in accordance with the synthetic polymer literature, comprises the rubbery zone, glass transition region, and glassy state. Application of Ferry's free-volume formalism and Rouse theory suggests that there is no change in the thermodynamic state of materials during vitrification, with changes in molecular weight simply introducing shifts in the time scale and temperature range of contributions to viscoelasticity. The thermorheological simplicity allowed development of the concept of "rheological" Tg. This was defined as the point between free-volume phenomena of the polymeric backbone occurring in the glass transition region and an energetic barrier to rotation required for local chain rearrangements in the glassy state. Mechanical relaxation and retardation distribution functions were calculated, thus obtaining values for the effective friction coefficient per monomer unit of the protein. It appears that the local friction coefficient is governed by a linear relationship between fractional free volume and the decreasing molecular weight of the protein, which introduces additional voids due to molecular ends.
Obstructive sleep apnea and carotid-artery intima-media thickness.

STUDY OBJECTIVES We investigated whether the carotid-artery intimamedia thickness (IMT) measured by ultrasonography, which is regarded as an indicator of atherosclerosis, was associated with the severity of obstructive sleep apnea (OSA). DESIGN Cross-sectional study. SETTING A sleep laboratory in a general hospital in Japan. PATIENTS A total of 167 patients referred to the sleep laboratory of our hospital for screening or treatment of OSA were investigated. They had no history of chronic obstructive pulmonary disease, cerebrovascular disease, or cardiovascular disease. INTERVENTIONS NA. MEASUREMENTS AND RESULTS Obstructive sleep apnea was diagnosed by polysomnography. Carotid-artery IMT was measured by ultrasonography, and known risk factors for atherosclerosis (age, obesity, hyperlipidemia, hypertension, diabetes mellitus, and insulin resistance) were also investigated. Multiple regression analysis was performed to assess the association between IMT and the severity of OSA, after adjusting for confounding factors. This analysis revealed that the apnea-hypopnea index, the duration of an oxygen saturation below 90%, and the mean nadir oxygen saturation were significantly associated with the IMT after adjustment for confounding factors that could promote atherosclerosis. Moreover, OSA-related hypoxemia was associated with the IMT independently of the apnea-hypopnea index. CONCLUSIONS Our results demonstrated that the severity of OSA is independently related to atherosclerosis and that the severity of OSA-related hypoxemia is more important than the frequency of obstructive events.
Effect of CO2, nutrients and light on coastal plankton. IV. Physiological responses

We studied the physiological response of phytoplankton to the interacting effects of 3 factors affected by global climate change: CO2, nutrient loading and irradiance. Treatments had a high and low level for each factor: CO2 was bubbled at 1000 ppm by volume versus present atmo spheric values; high nutrient treatments had a combination of inorganic and organic nutri- ents; and light treatments were obtained by covering the tanks with a single or double layer of screen. We measured esterase activity, oxidative stress (ROS), cell death, DNA damage, photosyn- thetic efficiency and 14 C assimilation as particulate or dissolved organic material (POC and DOC respectively). Conditions simulating future global change scenarios showed similar chlorophyll- normalized primary productivity as present conditions. The main effect driving phytoplankton physiology was the downregulation of the photosynthetic apparatus by elevated CO2, which decreased esterase activity, ROS, cell death and DNA damage. Nutrient concentration and light acted as additional modulators, upregulating or contributing to downregulation. The percentage of DO 14 C extracellular release (PER) was low (0 to 27%), significantly lower under ultraviolet radi- ation (UVR) than under photosynthetically active radiation (PAR), and acted mainly to re- equilibrate the internal balance when cells grown under UVR were exposed to PAR. PER was almost 3 times lower under high CO2, confirming a higher resource use efficiency of phytoplank- ton under future CO2 concentrations.
The Prevalence of Asymptomatic Intracranial Large‐Vessel Occlusive Disease: The Role of Diabetes

Objective. To investigate the prevalence of asymptomatic intracranial stenosis using transcranial Doppler ultrasonography in patients with evidence of asymptomatic carotid stenosis. Background. Symptomatic atherosclerotic intracranial largeartery stenosis accounts for approximately 10% of ischemic strokes annually. It is unknown whether a significant risk for stroke is associated with asymptomatic intracranial stenosis, especially in patients with known asymptomatic carotid disease. Design and Methods. Transcutaneous real‐time B‐mode Doppler ultrasonography was performed on 510 patients referred for the evaluation of asymptomatic carotid bruits. A peak systolic flow velocity > 1.40 m/s indicated carotid stenosis. Transcranial Doppler ultrasound was performed to identify intracranial large‐artery disease. The peak systolic flow velocity indicating stenosis was > 120 cm/s for anterior circulation and > 100 cm/s for posterior circulation. Demographic and cerebrovascular risk factor information was recorded at the time of examination. Chi‐square analysis with Pearson correction was performed to examine the significance of the findings. Results. Five hundred ten patients (252 male, 258 female) aged 71.4±10.45 years were studied. The laboratory's accuracy was previously established as 93% for each technique for laboratory certification. Two hundred patients (39.2%) were found to have extracranial carotid stenosis, and 66 (12.9%) were found to have intracranial stenosis. Thirty‐seven patients (56%, P < .01) were found to have concurrent stenosis. In patients with intracranial stenosis, 19 (28.8%, P < .03) had diabetes, and 26 (39.4%, p < .03) had coronary disease. There was no corresponding correlation with extracranial carotid disease and diabetes or coronary artery disease. Conclusions. The prevalence of patients with asymptomatic intracranial stenosis with concurrent carotid stenosis was greater than expected. Coexisting diabetes and coronary disease were significant risk factors in this population. Doppler ultrasonography may be a useful technique in delineating asymptomatic intracranial stenosis in those patients with existing carotid stenosis. Further studies are needed to clarify the risk of this population for stroke from asymptomatic intracranial stenosis and to determine optimal therapy.