Miracle-dz/UniFAR-FTUs huggingface dataset:
6-17-2019 System Dynamics to Investigate Opioid Use and Chiropractic Care for Chronic Musculoskeletal Pain

Objective: The purpose of this investigation was to create a system dynamics (SD) model, including published data and required assumptions, as a tool for future research identifying the role of chiropractic care in the management of chronic, nonmalignant pain in a Canadian population. Methods: We present an illustrative case description of how we evaluated the feasibility of conducting a large-scale clinical trial to assess the impact of chiropractic care in mitigating excessive opioid use in Canada. We applied SD modeling using current evidence and key assumptions where such evidence was lacking. Modeling outcomes were highlighted to determine which potential factors were necessary to account for compelling study designs. Results: Results suggest that a future clinical study diverting patients with nonmalignant musculoskeletal pain early to the chiropractic stream of care could be most effective. System dynamics modeling also highlighted design challenges resulting from unresearched assumptions that needed to be proxied for model completion. Assumptions included changing rates in opioid-associated deaths and rates of success in treatment management of addicted patients. Conclusion: In this case, SD modeling identified current research gaps and strong contenders for appropriate followup questions in a clinical research domain, namely the role of chiropractic care in the management of chronic, nonmalignant pain in a Canadian population. (J Manipulative Physiol Ther 2019;xx:1-xxx) Key Indexing Terms: Chronic Pain; Musculoskeletal Pain; Pain Management; Chiropractic; Opioid-Related
Seroprevalence of Hepatitis C Virus Infection in Kohat Division , KhyberPakhtoonkhwa , Pakistan

The current study was conducted to investigate prevalence of Hepatitis C virus (HCV) infection in Kohat division. A total of 270 ICT (Immunuochromatography test) positive male and female subjects were included in this study and divided into three groups according to their age. Blood samples were collected and processed to confirm the anti-HCV status and data was collected on pretested questionnaires to identify the risk factors. Out of 270 ICT positive patients, 224 were confirmed positive by ELISA (Enzyme Linked Immunosorbent Assay). Results revealed that male population was more affected (46.29%) as compared to female (36.66%). The people with age group 15-40 years were found to be more affected (87.03%) followed by above 40 years (30.37%). The mean age group of HCV positive for male was 37.57±7.85 while for female i.e., 38.26±8.47. Infection was related to different risk factors and it was observed that 69.25% patients have the history of hospitalization, 50.37% piercing, 39.25% blood transfusion, 17.40% dental treatment, 31.85% surgical procedure, 22.22%have shaving practices at barber shops while 14.44% have tattooing on body. Statistical analysis shows that both educational and occupational status is significantly associated with anti-HCV antibody. Other factors associated significantly with infection were blood transfusion (p-value <0.0001, OR (Odds Ratio) =0.021, CI (Confidence Interval) =0.0050-0.0913), dental treatment (p-value=0.0059, OR=0.367, CI=0.176-0.764) and diagnosis in family member (p-value=0.0012, OR=0.3508, CI=0.183-0.6710). Most of the factors associated significantly with infection are demographic and hospital associated, reflecting the fact of unawareness of disease in public, improper sterilization of instruments in hospitals and poor blood
Efficient Object Tracking based on Circular and Structural Multi-level Learners

We propose a novel efficient tracking framework. Firstly, we incorporate DCF and SOSVM to obtain a novel formulation for training circular and structural learners (CSL). Secondly, we introduce a collaborative optimization strategy to update the learners, which significantly reduces computational complexity and improves robustness. Thirdly, we observe the fact that features extracted from only single-level are not robust to handle all challenge factors, thus we suggest to get a multi-level confidence score map with deep features in the continuous spatial domain, and we exploit an implicit interpolation model to extract multi-resolution complementary deep features based on different pre-trained CNNs, including both the deep appearance features and deep motion features of the target. Finally, in order to get an optimal confidence score map for more accurate localization, we propose a novel ensemble post-processor which based on relative entropy to combine the sing-level confidence score maps. Comprehensive evaluations are conducted on three object tracking benchmarks. Our approach obtains an absolute gain of 0.3% and 0.6% in mean AUC score compare to the top-ranked method on the OTB-2013 and OTB-2015 benchmarks, respectively, and provides a third-best performance with expected average overlap (EAO) score of 29.8% on the VOT2017 challenge, while operates at frame-rate.
The Effect of Thymus vulgaris Extracts on Enterotoxins ( A-D ) Production by Staphylococcus aureus Isolated from Urinary Tract Infection

One hundred and eighty five urine samples were collected eight isolates (4.3%) were obtained and diagnosed as Staphylococcus aureus. The identification of all S. aureus isolates was confirmed by conventional biochemical tests. Among 8 isolates, 5 (62.5%) S. aureus isolates were found to be enterotoxigenic . Approximately most of isolates produced at least two types of staphylococcal enterotoxins ( SEs). These enterotoxins may be important in the physiopathology of urinary tract infection . The production of staphylococcal enterotoxins (A– D) in the presence or absence of Thymus vulgaris the crude extracts (aqueous and alcoholic ) were was estimated in microtiter plates using a reversed passive latex agglutination (SETRPLA) kit . The extracts reduced enterotoxin production at subminimal inhibitory concentrations compared with the control. At 400 μg/ml , total enterotoxin inhibition was observed for enterotoxin C production, whereas production of enterotoxins A, B, and D were totally eliminated at 800 μg/ml . The results show that the aqueous and alcoholic extracts from the leaves of T. vulgaris significantly decreased, in a dose-dependent manner, the production of SEA, SEB,SEC and SED by S. aureus .
The Effects of Mannan Oligosaccharide and Chitosan Oligosaccharide on Performance and Blood Parameters of Broilers

Bu arastirma, broyler rasyonlarina mannan oligosakkarit (MOS) ve kitosan oligosakkarit (KOS) ilavesinin performans ve bazi kan parametreleri uzerine etkisini degerlendirmek amaciyla yapilmistir. Denemede toplam 120 adet erkek broyler civciv kullanilmistir. Her bir denemede, 10 civcivden olusan 4 tekrarli grup kullanilmistir. Deneme 6 hafta surmustur. Deneme rasyonlari, kontrol grubu (basal rasyon); MOS grubu (basal rasyon + 100 ppm Mannan oligosakkarit) ve KOS grubunu (basal rasyon +100 ppm Kitosan oligosakkarit) icermektedir. Arastirma sonunda, rasyona MOS ve KOS ilavesinin canli agirlik, canli agirlik artisi, yem tuketimi, yemden yararlanma orani, karkas randimani ve bazi kan parametreleri uzerine istatistiksel olarak etkisi gozlenmemistir. MOS ve KOS ilave edilen grup, kontrol grubu ile karsilastirildiginda, serum Cu seviyesi onemli bir sekilde artmistir. Sonuc olarak rasyona MOS ve KOS ilavesi broylerlerde sadece serum Cu duzeyinde gelismeye sebep olmustur.
Comparative study of B-ultrasound and CT in preoperative diagnosis of myometrial invasion and lymph node metastasis in endometrial carcinoma

Objective: To examine the diagnostic performance of B-ultrasound and CT in preoperative assessment of endometrial carcinoma. Methods: From January 2015 to December 2017, a retrospective analysis was performed for the clinical data from 100 patients admitted to our hospital who had endometrial carcinoma confirmed by postoperative pathologic examination. All patients received B-ultrasound and CT examination before surgery. Postoperative pathologic findings were taken as the gold standard. The specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV) and Youden’s index of the two imaging techniques were compared in preoperative diagnosis of myometrial invasion and lymph node metastasis. Agreement analysis (kappa test) was used to evaluate the performance of B-ultrasound and CT in preoperative diagnosis of myometrial invasion and lymph node metastasis. Results: In diagnosis of myometrial invasion, the specificity, sensitivity, PPV, NPV and Youden’s index of B-ultrasound were 69.6%, 61.0%, 87%, 34.8% and 0.306, respectively, and the corresponding values of CT were 78.3%, 66.2%, 91.1%, 40.9%, and 0.445, respectively. The diagnostic measures of CT were better than those of B-ultrasound, but the difference was statistically insignificant. In diagnosis of lymph node metastasis of endometrial carcinoma, the specificity, sensitivity, PPV, NPV and Youden’s index of B-ultrasound were 100%, 25.0%, 100%, 90.7% and 0.250, respectively; the corresponding values of CT were 96.6%, 75.0%, 75.0%, 96.6% and 0.716, respectively. Among them, the value for sensitivity of CT was significantly better than that of B-ultrasound (P=0.041), and the rest diagnostic measures were not significantly different between the two imaging techniques. Agreement analysis (kappa test) showed that there were poor agreements between preoperative B-ultrasound diagnosis of myometrial invasion and lymph node metastasis and the corresponding postoperative pathologic findings. There was also a poor agreement between preoperative CT diagnosis of myometrial invasion and the corresponding postoperative pathologic findings, but there was a good agreement between preoperative CT diagnosis of lymph node metastasis and the corresponding postoperative pathologic findings. Conclusion: CT may have a better performance in preoperative diagnosis of myometrial invasion and lymph node metastasis in patients with endometrial carcinoma than B-ultrasound.
Associated Factors to Nutritional Status and Infant and Young Child Feeding (IYCF) Practices in Rural Area of Burkina Faso: A Study in Ouargaye Health District

Although the global trend of malnutrition among children under five is declining, it remains a major public health problem in developing countries such as Burkina Faso. IYCF are major determinants of nutritional status and hence health and child survival. Material and Method: We carried out a cross-sectional study in primary health care centers randomly selected. The objectives of this work were to analyze associated factors to children’s nutritional status and child feeding. The Z-scores (WHO, 2006) were used to determine nutritional’s status of the children. The quality of feeding practices was assessed according to IYCF index. Results: In total, we surveyed 287 children. The average age of children was 10.87 months. The sex ratio was at 1:11. Among children, the prevalence of underweight was 19.2%, that of stunting 31.2% and that of wasting 10.1%. Multigravidity was the predictive risk factor related to underweight in children. Practice of EBF was associated with Z-score Height/Age (p=0.04). The majority (70%) of children had a good score of IYCF index. Among children aged 9–12 months, the Z-score Height/Age (p=0.04) and Z-score Weight/Height (p=0.001) were associated with IYCF index in univariate analysis. For those with at least 12 months of age, sex ant type of habit was the predictive risk factors associated to IYCF index. Conclusion: Malnutrition is common in children. Feeding practices are good and are not associated with sociodemographic characteristics of mothers. IYCF index score decreases with age and is lower after 12 months.
Correctional Nurse Competency and Quality Care Outcomes Corresponding

Purpose: In this paper, we report on the clinical care outcomes resulting from implementing a nurse competency education intervention to a nursing staff in a statewide correctional system. Background: State correctional healthcare systems face ongoing and serious challenges attracting and retaining an adequate number of qualified health professionals owing to the perceived undesirability of working in correctional facilities; high occupational stressors; and the effects of high turnover on the workloads of remaining nursing staff. Methods: Nursing outcomes were evaluated on four most frequently used nursing protocols. The education intervention consisted of self-directed computer-based modules, hands-on clinical review of skills, and validation of learning through high-fidelity simulation tailored for the correctional environment. A multilevel random coefficient modeling approach for analysis was utilized. Records reviewed at 7 facilities comprising a sample of 736 records were compared for nursing care performance between facilities. Findings: The education intervention as designed increased nurse competency (t= 2.591, df=729, p=0.010) on average 4% across the state system (facility range -4% to +10.8%). A four percent system change has been found to be an effective rate of change in other studies. Facilities with an overall higher RN to LPN ratio perform at a relatively high level (t=4.211, df=730, p=0.000). Increase in inmate census without change in RN/LPN nurse staffing reduced performance (t= -4.347, df=730, p=0.000). Conclusions: This multi-component nursing education intervention improved quality of nursing care, most dramatically in the area of psychiatric care. Structural challenges related to paper charts and security suggest improvements may be seen with an electronic record system and expanded training between nursing and Correctional Officers for health care. An examination of the effectiveness of current models of care delivery may be warranted. This article is available in Journal for Evidence-based Practice in Correctional Health: https://opencommons.uconn. edu/jepch/vol2/ iss1/3 Correctional Nurse Competency and Quality Care Outcomes Corresponding Author: Deborah Shelton, PhD, RN, NE-BC, CCHP, FAAN Professor Emeritus, School of Nursing Center for Correctional Health Networks, University of Connecticut Consultant, Shelton Consulting Services SheltonConsultingServices@gmail.com 860-268-4425 William Barta, PhD Assistant Chief Quantitative Research Unit New Jersey State Judiciary Research Associate, Center or Correctional Health Networks Louise Reagan, PhD, APRN, ANP-BC, FAANP Assistant Professor, School of Nursing Director, Center for Correctional Health Networks
Relationship between Progression-free Survival and Overall Survival in Randomized Clinical Trials of Targeted and Biologic Agents in Oncology

Introduction: With a gap in a full understanding of the mechanisms by which survival is extended for patients with cancer who are treated with novel biologic and targeted agents, there is the risk that discordant progression-free and overall survival outcomes are observed due to poor clinical trial design or biases in the interpretation of data. This study was designed to examine the role of study quality and design on the outcomes observed with biologic and targeted agents. Methods: A review of studies in clinicaltrials.gov supplemented with a literature review in OVID Medline was conducted to identify all randomized trials of a biologic/targeted agent versus a non-biologic/targeted comparator in oncology that report both median overall and progression-free survival outcomes. Details of the study, design, population, drugs, and outcomes were extracted. Study quality was evaluated using the PEDro scale. Data were summarized using SPSS 22.0.0. 0. Results: A total of 192 unique studies of 206 pairwise comparisons between a biologic/targeted and comparator were identified. The average absolute magnitude of post-progression survival (difference between OS and PFS) was 9.7 months for biologic/targeted therapy and 9.8 for the comparator. A total of 64 comparisons (31.1%) showed an increase in OS and decrease in PFS, or vice versa, and 25 (12.1%) showed a magnitude of more than 4 months difference between the delta of OS and delta of PFS between the biologic/targeted and comparator arms. Average study quality was high overall (7.7/10), and was comparable for studies with directional differences (7.2/10) as well as for those with the greatest magnitude in post-progression survival (7.4/10). Conclusion: This review and analysis specifically examined small PFS benefit with large OS benefit as well as small OS benefit with large PFS benefit, including differences in direction of PFS and OS outcomes. No evidence was identified that these are the result of poor study design, but may rather be due to the mechanism of action, specific disease, and population under study. Further work is needed to understand the mechanism of action of novel biologic/targeted agents to better understand their interaction with the tumor microenvironment.
Recipe to Reproduce the Solar System R-Process Abundances

The astrophysical site for the r-process has not yet been uniquely identified. Neutron star mergers (NSMs) have recently received special attention as production sites for the r-process. The ejected matter from the NSMs is extremely neutron-rich (Ye < 0.1) and the r-process path proceeds along the neutron drip line and enters the region of fissile nuclei. In this situation, theoretical models of nuclear masses and fission modes are quite important. In this study, we carry out r-process nucleosynthesis simulations in NSMs based upon recent numerical simulations. We here constructed a nuclear reaction network code and utilize a new model for nuclear masses and a fission fragment distributions. In our nucleosynthesis simulations the final r-process elemental abundances exhibit a very flat distribution for A= 90−180. This due to the fact that several fission cycles occur in the extremely neutron-rich conditions of NSMs. Combining these results with magneto-rotationally driven core-collapse supernovae (CCSNe) that predict successful r-process abundance peaks at A ∼ 130 and 195, we find that NSMs can resolve the underproduction problems of such CCSN models for the isotopes just below and above the abundance peaks. We discuss the relative contributions to the solar-system r-process yields from CCSNe and NSMs.
tionof pottery from consumer sites with that of pottery from production sites. How ever,in the case of the analysis of pottery from the prehistoric Jomon period of Japan

The purpose of this paper is to examine whether Jomon pottery from two neighboring sites can be chemically distinguished from each other. For this purpose, minor and trace element composition of Jomon potsherds from the Honmura-cho and Isarago sites was determined using energy dispersive x-ray fluores cence(EDXRF). The results supported the hypothesis that the majority of the Ear lyJomon pottery from each of these two sites was produced locally using different raw materials. The paper also demonstrates the utility of multi-element, multivari ateanalyses for distinguishing pottery made in different locations.
Increasing the Accuracy of Blood Hematocrit Measurement by Triplicate Wavelength Photoplethysmography Method

Email: m_azarnoosh@mshdiau . ac.ir Abstract Background and objectives: The importance of continuous monitoring and rapid and accurate informing of changes in blood components (e.g., percentage of hematocrit [HCT]), especially in acute conditions, has motivated researchers to use non-invasive measurement methods. Therefore, this study aimed to evaluate the association between blood HCT and photoplethysmographic signal and the possibility of increasing the accuracy of its measurement by optical method at three specific wavelengths.
We present results of a simulation of a substorm on 23 March 2007 using the one ‐ way coupled

[1] We present results of a simulation of a substorm on 23 March 2007 using the one‐way coupled Open Geospace General Circulation Model–Rice Convection Model (OpenGGCM/RCM). In the standalone RCM, inputs are typically taken from empirical models or inferred from satellite data; however, in this simulation, the OpenGGCM magnetic field and plasma information are used to supply inputs and boundary conditions for the RCM. The OpenGGCM ionospheric potential is used to drive a RCM run. That simulation is used to investigate the short time scale dynamics that occurred around substorm onset and assumes the OpenGGCM has a realistic representation of the inner magnetospheric magnetic field during this event. In these runs, a channel of low total entropy plasma opened up on the RCM tailward boundary around substorm onset, and plasma bubbles were injected into the inner magnetosphere. These bubbles were produced by nonadiabatic processes in the OpenGGCM such as magnetic reconnection. We compare the RCM energetic particle flux with measurements from two Los Alamos National Laboratory (LANL) satellites. A dispersionless electron injection is reproduced at the LANL‐89 location and a dispersed flux increase at the LANL‐97A location. The results indicate the low‐PV 5/3 plasma accompanying magnetic field dipolarization produced earthward plasma motion as the result of these low‐entropy flux tubes interchanging their way into the inner magnetosphere; this process may play an important role in substorm particle injection. A comparison simulation in which the electric field is solved by the RCM is also presented, suggesting the need to use RCM’s electric field for more accurate inner magnetosphere modeling.
NEK 2 is up-regulated in oral squamous cell carcinoma and correlates with patients ’ disease severity

Background: Nek2 is a centrosome kinase and an important regulator in mitosis. Nek2 overexpression has been observed in many cancers including breast cancer, colorectal cancer and pancreatic cancer. However, Nek2 expression has not been examined in oral squamous cell carcinoma (OSCC). Objective: Our study aims to examine the expression of Nek2 in OSCC and explore its correlation with patients’ clinical features and disease severity. Methods: Sixty tissue specimens were collected from 60 OSCC patients who underwent surgical treatment at the Stomatological hospital affiliated to Guizhou Medical University, China. Sixty normal oral tissues were collected from 60 ageand sex-matched healthy controls. Expression of Nek2 was assessed by Reverse Transcription-Polymerase Chain Reaction assay and Immunohistochemistry. Results: Nek2 was up-regulated in OSCC tissues at both the mRNA and protein level compared to control group (P<0.05). Expression of Nek2 in patients with lowly differentiated OSCC was higher than that of patients with highly differentiated OSCC. Expression of Nek2 was higher in patients with stage III and IV than patients with stage I and II OSCC. Higher Nek2 expression was also associated with the presence of vascular and nerve invasion, lymph node and distant metastasis. Conclusions: Expression of Nek2 in OSCC is markedly increased at both the mRNA and protein level; the increased expression of Nek2 correlates positively with clinical stages and tumor differentiation.