Miracle-dz/UniFAR-FTUs huggingface dataset:
"Difficult" patient? Or does he have a personality disorder?

CASE u Bob a, age 48, comes to his family physician (fp) to ask for authorization for extended medical leave from his job as an electrician. he frequently misses days at work and complains of stress on the job, saying his coworkers look down on him and make cruel jokes at his expense. he reports having chronic interpersonal conflicts and no significant relationships with family members or friends. mr. a refuses a referral to a psychiatrist because he fears he will be “locked up and forced to take medications. ” if mr. a were your patient, how would you proceed?
Ionizing radiation utilizes c‐Jun N‐terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells

Exposure of cells to ionizing radiation induces activation of multiple signaling pathways that play a critical role in controlling cell death. However, the basis for linkage between signaling pathways and the cell‐death machinery in response to ionizing radiation remains unclear. Here we demonstrate that activation of c‐Jun N‐terminal kinase (JNK) is critical for amplification of mitochondrial cell death in human cervical cancer cells. Exposure of HeLa cells to radiation induced loss of mitochondrial membrane potential, release of cytochrome c and apoptosis inducing factor (AIF) from mitochondria, and apoptotic cell death. Radiation also induced transcriptional upregulation of Fas, caspase‐8 activation, Bax and Bak activation, and phosphorylation and downregulation of Bcl‐2. Inhibition of caspase‐8 attenuated Bax and Bak activation, but did not affect phosphorylation and downregulation of Bcl‐2. Expression of a mutant form of Bcl‐2 (S70A‐Bcl‐2) completely attenuated radiation‐induced Bcl‐2 downregulation. Interestingly, inhibition of JNK clearly attenuated radiation‐induced Bax and Bak activation, and Bcl‐2 phosphorylation as well as Fas expression. In addition, dominant‐negative form of c‐Jun inhibited radiation‐induced Fas expression and Bax and Bak activation. These results indicate that the JNK–c‐Jun pathway is required for the transcriptional upregulation of Fas and subsequent activation of Bax and Bak, and that JNK, but not c‐Jun, is directly associated with phosphorylation and downregulation of Bcl‐2 in response to ionizing radiation. These results suggest that ionizing radiation can utilize JNK for amplification of mitochondrial apoptotic cell death in human cervical cancer cells.
Approximate Controllability of Fractional Stochastic Perturbed Control Systems Driven by Mixed Fractional Brownian Motion

In this paper, the approximate controllability of nonlinear Fractional order 0<<1 Riemann-Liouville type stochastic perturbed control systems driven by mixed fractional Brownian motion in a real separable Hilbert spaces has been studied by using Krasnoselskii's fixed point theorem, stochastic analysis theory, fractional calculus and some sufficient conditions.
Filamentous Capsulated Streptococci from the Human Respiratory Tract II. Antigenic Structure of Provisional Capsular Types 89 and 83/89

Two immunologically distinct polysaccharides have been isolated from the filamentous alpha-hemolytic streptococcus of provisional capsular type 89, recovered from the human respiratory tract. Chemical analyses indicate that the capsular polysaccharide consists of glucose, galactose, and a small amount of rhamnose, whereas the cell wall-associated polymer contains galactosamine, glucosamine, glucose, and phosphorus. Immunological studies suggest that the capsular polysaccharide is type specific and that the cell wall-associated carbohydrate, which cross-reacts with the C8, or cell wall-like capsular polysaccharide of pneumococcus, may be group specific. A noncapsulated variant of the prototypic streptococcus of provisional type 89 was shown to possess the same cell wall-associated carbohydrate as the strain from which it was derived, but it proved to be poorly antigenic in rabbits. A filamentous capsulated streptococcus reacting with antisera to filamentous streptococci of both provisional capsular types 83 and 89 has been found to produce two capsular polysaccharides, each of which reacts with antibody to one of the aforementioned unitypic strains and represents an unusual binary capsulated streptococcus.
Pulmonary Thromboembolism: Epidemiology and Techniques of Nuclear Medicine

Pulmonary thromboembolism is a very common disease (about 500,000 events per year in the United States). The most important risk factors seem to be age, cancer, previous surgery, trauma, coagulation disorders, and immobilization. Analysis of epidemiologic studies shows that the incidence of pulmonary embolism is underestimated clinically. Combined ventilation/perfusion scintigraphy is an established method for the diagnosis of pulmonary embolism, but the specificity of the method still is not high enough. Diagnostic strategies and new techniques in nuclear medicine will probably be able to improve the quality of the management of patients with clinically suspected pulmonary embolism.
Effects of the estrous cycle and early pregnancy on bovine uterine, luteal, and follicular responses.

Uterine, luteal, and follicular responses associated with the estrous cycle and early pregnancy in cattle were examined. Dairy (n = 19) and beef (n 19) cattle were slaughtered either on Day 4, 8, 12, 14, 16, or 19 postestrus (estrus = Day o). Corpus Iuteum (CL) weight, specific PGF20 binding by the luteal particulate fraction (100,000 X g pellet), in vitro estradiol (E2) production by the two largest follicles, total recoverable uterine luminal protein (TP), total recoverable iinmunoreactive uterine luminal PGF (TPGF), and peripheral plasma steroids were evaluated. In a parallel study, beef cattle (n 22) were slaughtered either on Day 8, 12, 14, 16, or 19 of pregnancy for measurements of TP, TPGF, and plasma steroids. Uterine luminal proteins, from cyclic and pregnant cattle (Day 19), were subjected to sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) for determination of protein molecular weights and protein profile characterization. In cyclic cattle, CL regression was not completed by Day 19. Follicle E2 secretion varied among animals within day (,i = 4.0-24.0 ng E2 /follicle/3.5 h; P<0.O1), but not among days. Total PGF2a binding (fmole/CL) for Days 4, 8, 12, 14, 16, and 19 was 14.29, 145.79, 177.34, 111.82, 174.51, and 199.17 (P<O.ol). TPGF (ng) varied among cycle Days 4 (14.4), 8 (13.9), 12 (19.7), 14 (47.7), 16 (17.4), and 19 (111.0 ng: P<0.01). In contrast, TPGF (ng) from pregnant cattle was 481.6 and 1187.8 ng on Day 16 (n 5) and 19 (n = 6). TP (mg) in cyclic cattle varied (P<0.05) among Days 4 (7.34), 8 (7.03), 12 (4.14), 14(15.92), 16 (5.88), and 19 (11.35). Mean TP (mg) for pregnant cattle ranged from 2.73 to 12.09. Thirty-two protein categories were identified in cyclic cattle uterine flushings by SDS-PAGE (Mr range X i(T� = 18.7 to 292.0). Proteins appeared with greater frequency later in the cycle than earlier (Days 14, 16, 19: 60% vs Days 4, 8, 12: 45%). Composite SDS-PAGE profiles from Days 8-12 and Days 14-16 differed (P<0.10) suggesting luteal phase stimulation of protein secretion. Protein profiles (SDS-PAGE) from Day 19 of pregnancy differed from Day 19 of the estrous cycle, resembled those of midluteal phase, and revealed four protein constituents possibly unique to early pregnancy. In summary, uterine luminal PGF increased with luteal phase of the estrous cycle at a time when there appeared to be a stable population of specific PGF2a binding sites in the CL. Higher PGF in utero at Days 16 and 19 of pregnancy and changes in TP and SDS-PAGE protein profiles may reflect responsiveness of endometrium to changes in ovarian status (cyclic) and/or conceptus activity (pregnancy comparisons).
Modeling of an Electron Injector for the AWAKE Project

Particle-in-cell simulations were performed by using PARMELA to characterise an electron injector with a booster linac for the AWAKE project in order to provide the baseline specifications required by the plasma wakefield experiments. Tolerances and errors were investigated. A 3 GHz travelling wave structure designed by using CST code. Particles were tracked by using the field maps acquired from these electromagnetic simulations. These results are pre- sented in comparison with the generic accelerating structure model within PARMELA.
Analytic Provenance Datasets: A Data Repository of Human Analysis Activity and Interaction Logs

We present an analytic provenance data repository that can be used to study human analysis activity, thought processes, and software interaction with visual analysis tools during exploratory data analysis. We conducted a series of user studies involving exploratory data analysis scenario with textual and cyber security data. Interactions logs, think-alouds, videos and all coded data in this study are available online for research purposes. Analysis sessions are segmented in multiple sub-task steps based on user think-alouds, video and audios captured during the studies. These analytic provenance datasets can be used for research involving tools and techniques for analyzing interaction logs and analysis history. By providing high-quality coded data along with interaction logs, it is possible to compare algorithmic data processing techniques to the ground-truth records of analysis history.
Hematuria One Stop Clinic: First Experience in Italy with 150 Cases

Objectives Starting from the UK experience, we decided to test both the feasibility and the advantages of this diagnostic pathway now established in an Italian hospital. We analyzed the outcomes in detecting transitional cell carcinoma (TCC) of the bladder, other malignant and non-malignant conditions. Materials an d Methods Between April and December 2010, one hundred and fifty patients presenting with hematuria were referred to the Hematuria One Stop Clinic (HOSC) at our Institution. Each patient underwent a visit, a Urinary Tract Ultrasound, a Cystoscopy and CT IVP in selected cases (evidence of alterations or lesions of the renal parenchyma, presence of stones of the urinary tract, evidence of doubtful or positive urinary cytology). Where a TCC of the bladder was diagnosed, the patient underwent TURBT In other cases (stones, BPH etc.) the appropriate therapeutic pathway was followed. Results 25.3% of patients with hematuria were found to have a bladder cancer; 21.3% had a urinary stone (2% in the bladder); 1.3% had prostate cancer; 1.3% had a renal cell carcinoma. The mean age was 69.8 yrs. 6% of the patients (23.6% on patients with TCC of the bladder) had a G3 disease. The mean time from admission to the HOSC until the operation day, in case of TCC of the bladder, was 10.61 days. Conclusions The Italian experience of the One Stop Clinic confirms a high rate of bladder cancer detection. Furthermore, a high rate of non-malignant conditions was detected, stressing the importance of the HOSC not only as a cancer clinic but as a complete general urological clinic. We report a shorter waiting time to operation, especially for bladder TCC G3 patients.
Clinical and pathological features of acute optic neuritis in Chinese patients

Background The incentives and the factors that affect the onset and outcome of optic neuritis (ON) are not very clear. The aim of this study is to define and get a comprehensive understanding of the clinical profile of ON, and to identify the factors that were related to the prognosis of the patients. Methods Medical records of patients with diagnosis of ON at Huashan Hospital, Fudan University between March 2008 and June 2011 were reviewed. Clinical features, ophthalmologic and neurologic assessments, neuroimaging studies, laboratory examinations, visual recovery, and final outcome of the patients were evaluated by the authors. Results Records of 50 patients (32 females and 18 males), aged 15‐56 years, were reviewed, in which 22% patients had a previous onset of ON. Maximal visual deficit was severe in 72.5% (<20/200). Abnormal rates of hormone levels and rheumatoid indicators were found in 54.2% and 25.0%. ANA test returned positive in 40%, oligoclonal banding (OCB) was identified in 31.3%, and Serum neuromyelitis optica (NMO)‐IgG studies were abnormal in 25% of the patients. Neuroimaging abnormalities associated with ON were documented in six patients. Three of the 50 patients have been diagnosed with multiple sclerosis, and two with NMO. Visual acuity was 20/20 or better in 26.1% and 20/100 or worse in 39.1% affected eyes at the last visit. Poor visual acuity at onset is the main factor that would affect the final outcome of vision (P <0.05). Conclusions Vision defects of this group of patients were severe. Females had a higher incidence of ON than males. Hormone levels, rheumatoid indicators and immune parameters may be related to the onset of ON. The severe reduction of visual acuity at onset may be related to the poor outcome of vision in ON patients.
Association of insulin resistance, viral load, and adipokine levels with liver histology in patients with chronic hepatitis C: an observational, multicenter study in Turkey

Objective To evaluate the association of insulin resistance (IR), viral load, and adipokine levels with liver histology in patients with chronic hepatitis C (CHC). Patients and methods In this noninterventional, multicenter study carried out at 11 infectious diseases clinics in Turkey, 103 CHC patients [mean (SD) age: 50.2 (11.0) years, 60 (58.3%) women] planned to be treated by ribavirin and peginterferon-&agr;2a were included. Data on hepatic fibrosis and steatosis, IR, viral load, and hepatitis C virus-RNA genotyping, adipokine, and cytokine levels were collected. Results The mean (SD) Knodell score was 8.1 (3.6); grade I steatosis was evident in 46 (44.7%) patients and IR was identified in 56 (54.9%). There was a significant positive correlation of the homeostasis model assessment-IR index with Knodell fibrosis (r=0.235; P=0.027) and hepatic steatosis (r=0.435; P<0.001). There was a significant positive correlation of leptin levels with Knodell fibrosis (r=0.265; P=0.013) and hepatic activity index (r=0.218; P=0.041). Hepatic steatosis was correlated negatively with adiponectin (r=−0.320; P=0.001) and positively with leptin (r=−0.368; P<0.001) levels. Logistic regression analysis showed that increase in age [odds ratio (OR), 1.056; 95% confidence interval (CI), 1.005–1.110; P=0.030] was the only significant predictor of hepatic fibrosis (OR, 1.056; 95% CI, 1.005–1.110; P=0.030), whereas increase in age (OR, 1.066; 95% CI, 1.006–1.130; P=0.030), the presence of IR (OR, 5.621; 95% CI, 1.547–20.425; P=0.009), and decrease in adiponectin levels (OR, 0.808; 95% CI, 0.682–0.957; P=0.013) were the significant predictors of hepatic steatosis. Conclusion Our findings indicate a significant relationship of hepatic fibrosis and hepatic steatosis with IR and leptin levels, but not with the viral load in Turkish patients with CHC.
Cre‐mediated recombination in the pituitary gland

Summary: Organ‐specific expression of a cre recombinase transgene allows for the analysis of gene function in a particular tissue or cell type. Using a 4.6 kb promoter from the mouse glycoprotein hormone α‐subunit (αGSU or Cga) gene, we have generated and characterized a line of transgenic mice that express cre recombinase in the anterior and intermediate lobes of the pituitary gland. Utilizing a cre‐responsive reporter transgene, αGSU‐cre transgene expression was detected in the pituitary primordium and in all five cell types of the adult anterior pituitary. αGSU‐cre transgene activity was also detected in the cardiac and skeletal muscle. Little or no activity was evident in the gonads, adrenal glands, brain, ventromedial hypothalamus, or kidneys. The αGSU‐cre transgenic mice characterized here will be a valuable tool for examining gene function in the pituitary gland. genesis 28:167–174, 2000. © 2000 Wiley‐Liss, Inc.
Bacterial Production of Conjugated Linoleic and Linolenic Acid in Foods: A Technological Challenge

Conjugated linoleic acid (CLA) and conjugated linolenic acid (CLNA) isomers are present in foods derived from ruminants as a result of the respective linoleic acid (LA) and α-linolenic acid (LNA) metabolism by ruminal microorganisms and in animals’ tissues. CLA and CLNA have isomer-specific, health-promoting properties, including anticarcinogenic, antiatherogenic, anti-inflammatory, and antidiabetic activity, as well as the ability to reduce body fat. Besides ruminal microorganisms, such as Butyrivibrio fibrisolvens, many food-grade bacteria, such as bifidobacteria, lactic acid bacteria (LAB), and propionibacteria, are able to convert LA and LNA to CLA and CLNA, respectively. Linoleate isomerase activity, responsible for this conversion, is strain-dependent and probably related to the ability of the producer strain to tolerate the toxic effects of LA and LNA. Since natural concentrations of CLA and CLNA in ruminal food products are relatively low to exert their health benefits, food-grade bacteria with linoleate isomerase activity could be used as starter or adjunct cultures to develop functional fermented dairy and meat products with increased levels of CLA and CLNA or included in fermented products as probiotic cultures. However, results obtained so far are below expectations due to technological bottlenecks. More research is needed to assess if bacterial production kinetics can be increased and can match food processing requirements.
The emerging role of online communication between patients and their providers

Despite the explosion of online communication in the community, its use between patients and their health care providers remains low. However, rapidly growing patient and provider interest in using online communication has motivated organizations to consider options for deploying these new tools in clinical practice. In this paper, we describe the barriers and challenges health care providers and their organizations must address in developing and deploying these new tools. We formulate lessons from early experiences with e-mail and web-based communication in clinical settings. Finally, we provide a roadmap for developing and deploying these new tools in clinical practice. Health care providers and their organizations will need to consider issues related to technology, data management, operations, communication management, and financial support in order to successfully deploy online services and communication for patients in clinical settings.
H-type hypertension is an important risk factor of carotid atherosclerotic plaques

ABSTRACT Aim: To investigate the association of H-type hypertension with carotid atherosclerotic plaques in Chinese. Methods: This hospital-based large population study included 13192 patients and all the patients were sequentially recruited between May 2010 and May 2013 at the Health Medical Center of the Chinese PLA General Hospital. The subjects were divided into four groups: the H-type of hypertension group, isolated systolic hypertension, simple homocysteine (Hcy) group, and the control group without hypertension and Hcy. Univariate logistic regression analysis was performed to investigate the association of H-type hypertension with the odds of carotid atherosclerotic plaques. Results: Among the 13192 subjects, there were 9007 (68.28% of all subjects) patients with hyperhomocysteinemia and 3543 patients with H-type hypertension, which was 26.86% of all subjects and 74.45% of hypertension patients. 34.55% of all subjects (4558) had carotid atherosclerotic plaques. The carotid atherosclerotic plaques positive rate among four groups was significantly different (χ2 = 647.8988, P = 0.000). The carotid atherosclerotic plaques’ positive rate of patients with H-type hypertension was 49.31%, which was significantly higher than the other three groups. Univariate logistic regression analysis results indicated that significant correlations exist between high-Hcy hypertension and carotid atherosclerotic plaques. Incidence of carotid atherosclerotic plaques in H-type hypertension patients was 1.63 times that in patients with isolated systolic hypertension. Conclusion: H-type hypertension is independently associated with higher risk of carotid atherosclerotic plaques. H-type hypertension and Hcy should be the major intervention measures to decrease the incidence of carotid atherosclerotic plaques as well as the stroke in Health Practice Management.
Normative misperceptions and temporal precedence of perceived norms and drinking.

OBJECTIVE Previous research has shown that students overestimate the drinking of their peers, and that perceived norms are strongly associated with drinking behavior. Explanations for these findings have been based largely on cross-sectional data, precluding the ability to evaluate the stability of normative misperceptions or to disentangle the direction of influence between perceived norms and drinking. The present research was designed to evaluate (1) the stability of normative misperceptions and (2) temporal precedence of perceived norms and drinking. METHOD Participants were college students (N = 164; 94 women) who completed assessments of perceived norms and reported behavior for drinking frequency and weekly quantity. Most participants (68%) completed the same measures again two months later. RESULTS Results indicated large and stable overestimations of peer drinking for frequency and weekly quantity. Results also showed that for weekly quantity, perceived norms predicted later drinking, but drinking also predicted later perceived norms. Results for frequency revealed perceived norms predicted later drinking, but drinking did not predict later perceived norms. CONCLUSIONS These findings underscore the importance of longitudinal designs in evaluating normative influences on drinking. The present findings suggest that normative misperceptions are stable, at least over a relatively short time period. Findings support a mutual influence model of the relationship between perceived norms and drinking quantity but are more strongly associated with conformity explanations for the relationship between perceived norms and drinking frequency. Results are discussed in terms of implications for prevention interventions.
Functional similarities between human immunodeficiency virus type 1 and simian virus 40 kappa B proto-enhancers

To search for broadly active enhancer elements within the human immunodeficiency virus type 1 (HIV-1) long terminal repeat, we have used a proto-enhancer amplification assay. In this assay, the enhancer region of simian virus 40 (SV40) is replaced by heterologous regulatory sequences. Upon passage in African green monkey kidney cells. SV40 growth revertants can arise by amplification (usually duplication) of active protoenhancers within the heterologous sequences. Most of the HIV-1 U3 regulatory sequences were assayed; only amplification of one or both of the HIV-1 enhancer core kappa B motifs consistently resulted in viable SV40 virus. Examination of the cell-specific enhancer activity of the individual HIV-1 kappa B proto-enhancers showed that, like the broadly active SV40 kappa B proto-enhancer (C proto-enhancer), they are all active in noninduced cell lines of either lymphoid (H9 and Jurkat) or nonlymphoid (HeLa and CV-1) origin. Unexpectedly, one of three kappa B point mutants that exhibit little or no activity in unstimulated cells is as highly induced in stimulated Jurkat cells as are the wild-type kappa B proto-enhancers. This point mutation shows that kappa B-related proto-enhancers can display markedly different activation properties in unstimulated cells yet still activate transcription to similar levels in stimulated cells.