Miracle-dz/UniFAR-FTUs huggingface dataset:
Motion Sickness: Current Knowledge and Recent Advance

Motion sickness (MS) is a common physiological response to real or virtual motion. Numerous studies have investigated the neurobiological mechanism and the control measures of MS. This review summarizes the current knowledge about pathogenesis and pathophysiology, prediction, evaluation, and countermeasures of MS. The sensory conflict hypothesis is the most widely accepted theory for MS. Both the hippocampus and vestibular cortex might play a role in forming internal model. The pathophysiology focuses on the visceral afference, thermoregulation and MS‐related neuroendocrine. Single‐nucleotide polymorphisms (SNPs) in some genes and epigenetic modulation might contribute to MS susceptibility and habituation. Questionnaires, heart rate variability (HRV) and electrogastrogram (EGG) are useful for diagnosing and evaluating MS. We also list MS medications to guide clinical practice. Repeated real motion exposure and combined visual‐vestibular interaction training accelerate the progress of habituation. Behavioral and dietary countermeasures, as well as physiotherapy, are also effective in alleviating MS symptoms.
Random Generation and the Executive Control of Working Memory

A series of experiments explores the capacity for generating sequences of random responses, relating it to the central executive component of working memory. Experiment 1 shows a broadly similar pattern of redundancy increasing with speed of generation for both the verbal generation of digits and the manual pressing of keys. In both cases deviations from randomness are shown to reflect the increasing use of a limited number of stereotyped response sets. The remaining experiments use keyboard generation. Experiment 2 demonstrates that concurrent immediate serial recall decreases randomness, and that longer recall sequences produce less random output. Experiments 3 and 4 show that whereas simple counting has no effect on randomness, serial recall, semantic category generation, and concurrent digit generation have substantial effects, and a concurrent fluid intelligence test has the greatest influence on the randomness of key pressing. It is suggested that the task of random generation resembles that of category fluency because it requires the subject to switch retrieval plans and inhibit repetition. On this basis it is predicted that a task involving repeated switching of categories will interfere with generation, despite being predictable and having a low memory load. Experiments 5 and 6 confirm this prediction. Strengths and limitations of the switching hypothesis are discussed, as are the implications of our results for the analysis of executive processes.
Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats

Pomegranate (Punica granatum L.) seed oil (PGO) contains more than 70% cis(c)9,frans(f)11,c13–18:3 as conjugated linolenic acids (CLN). Our previous short‐term experiment demonstrated that seed oil from bitter melon (Momordica charantia) (BMO), which is rich in c9,t11,t13‐CLN, inhibited the occurrence of colonic aberrant crypt foci (ACF) induced by azoxymethane (AOM). In this study, we investigated the effect of dietary PGO on the development of AOM‐induced colonic malignancies and compared it with that of conjugated linoleic acid (CLA). To induce colonic tumors, 6‐week old male F344 rats were given subcutaneous injections of AOM (20 mg/kg body weight) once a week for 2 weeks. One week before the AOM treatment they were started on diet containing 0.01%, 0.1%, or 1%±PGO or 1% CLA for 32 weeks. Upon termination of the bioassay (32 weeks) colon tumors were evaluated histopathologically. AOM exposure produced colonic adenocarcinoma with an incidence of 81% and multiplicity of 1.88±1.54 at week 32. Administration of PGO in the diet significantly inhibited the incidence (AOM+0.01% PGO, 44%, P<0.05; AOM+0.1% PGO, 38%, P<0.01; AOM+1% PGO, 56%) and the multiplicity (AOM+0.01% PGO, 0.56±0.73, P<0<01; AOM+0.1% PGO, 0.50±0.73, P<0.005; AOM+1% PGO, 0.88±0.96, P<0.05) of colonic adenocarcinomas, although a clear dose‐response relationship was not observed at these dose levels. CLA feeding also slightly, but not significantly, reduced the incidence and multiplicity of colonic adenocarcinomas. The inhibition of colonic tumors by PGO was associated with an increased content of CLA (c9,t11–18:2) in the lipid fraction of colonic mucosa and liver. Also, administration of PGO in the diet elevated expression of peroxisome proliferator activated receptor (PPAR) γ protein in the nontumor mucosa. These results suggest that PGO rich in c9,t11,c13‐CLN can suppress AOM‐induced colon carcinogenesis, and the inhibition is associated in part with the increased content of CLA in the colon and liver and/or increased expression of PPARγ protein in the colon mucosa.
Diaporthe: a genus of endophytic, saprobic and plant pathogenic fungi

Diaporthe (Phomopsis) species have often been reported as plant pathogens, non-pathogenic endophytes or saprobes, commonly isolated from a wide range of hosts. The primary aim of the present study was to resolve the taxonomy and phylogeny of a large collection of Diaporthe species occurring on diverse hosts, either as pathogens, saprobes, or as harmless endophytes. In the present study we investigated 243 isolates using multilocus DNA sequence data. Analyses of the rDNA internal transcribed spacer (ITS1, 5.8S, ITS2) region, and partial translation elongation factor 1-alpha (TEF1), beta-tubulin (TUB), histone H3 (HIS) and calmodulin (CAL) genes resolved 95 clades. Fifteen new species are described, namely Diaporthe arengae, D. brasiliensis, D. endophytica, D. hongkongensis, D. inconspicua, D. infecunda, D. mayteni, D. neoarctii, D. oxe, D. paranensis, D. pseudomangiferae, D. pseudophoenicicola, D. raonikayaporum, D. schini and D. terebinthifolii. A further 14 new combinations are introduced in Diaporthe, and D. anacardii is epitypified. Although species of Diaporthe have in the past chiefly been distinguished based on host association, results of this study confirm several taxa to have wide host ranges, suggesting that they move freely among hosts, frequently co-colonising diseased or dead tissue. In contrast, some plant pathogenic and endophytic taxa appear to be strictly host specific. Given this diverse ecological behaviour among members of Diaporthe, future species descriptions lacking molecular data (at least ITS and HIS or TUB) should be strongly discouraged.
Intellectual Property Rights and Cross-Border Mergers and Acquisitions

We investigate the role of intellectual property rights protection in cross-border merger and acquisition (M&A) activity. We document a significant increase in inbound cross-border M&As after a country implements reforms that strengthen local intellectual property rights. Importantly, we find that intellectual property rights have an impact on merger activity only in industries that are more intellectual capital-intensive, and when the target country has weaker intellectual property rights protection than the acquirer country. We also find that synergy gains in cross-border M&As are positively related to reforms of intellectual property rights. These results are consistent with the notion that acquirers are concerned about the local protection of intellectual capital when considering foreign acquisitions, and care the most when the target firm is in an industry that uses intellectual property intensely and in a country that has lesser-developed protections that their own country does.
Intratumoral Distribution of 1p Loss in Oligodendroglial Tumors

The favorable response of oligodendrogliomas correlates well with characteristic chromosomal losses, of which loss of the short arm of chromosome 1 is most predictive. Oligodendrogliomas are histopathologically heterogeneous tumors and, in addition to the classic honeycomb histology, fields of nonclassic histology are often encountered. Information about the distribution of 1p loss in various regions of oligodendroglioma is, therefore, important to interpret findings in tumor biopsies. In this study we investigated the distribution of 1p loss in multiple fields in 24 biopsy specimens of oligodendroglioma consisting of classic and nonclassic histology by fluorescent in situ hybridization and loss of heterozygosity analysis. By fluorescent in situ hybridization analysis, loss of 1p was found in all fields examined in 37% of the tumor samples, and no loss was detected in 46%. In fields of classic oligodendroglial and polar spongioblastoma-like histology, significantly more loss for 1p was found (p < 0.001 and p < 0.01, respectively). Although fluorescent in situ hybridization analysis indicated heterogeneity for 1p loss in the other 17% of tumors, loss of heterozygosity analysis of these samples pointed to homogeneity of 1p status in all fields. The 1p status of the fields with classic histology significantly correlated with the status of the other fields in the same tumors (Spearman's rho 0.918, p < 0.001). These results point to genotypic homogeneity for 1p in oligodendroglial tumors.
Essays on the Measurement of Economic Growth

This essay analyses national accounting theory in retrospect. The aim is to create an interface to the inter-temporal and interspatial measurement of economic growth and size of economic systems. A formal system view is emphasized as it links up with the theory of economic indexes. 1. Theoretical Concepts and Operational Definitions 1.1 Economics and Science Modern economics is a quantitative discipline. Its models and theories are formulated chiefly mathematically. Classical physics was the first paradigm of modern empirical science. Formally, classical physics was written in calculus. The main variables of early classical physics were often directly measurable in numerical terms. The concepts of length, distance, mass and velocity seem obvious. Operational rules for measurement were rather straightforward after the measurement of time was made mechanical. Even before the emergence of classical physics there was a long tradition of quantitative measurement, e.g. geometry was applied in astronomy and navigation. The research object is in a state of evolution in most empirical sciences. This is well exemplified by the gamma of cosmology and evolution theory proper. In contrast to most natural sciences, the structural evolution of studied systems in social sciences is very fast. The object of modern microeconomics has fully existed at most for a few centuries. The proper object of modern macroeconomics emerges even later. Because of its latter-day birth economics has often adopted formal ideals from classical natural sciences (see e.g. Porter in Mirowski, 1994, p. 153). Themes like constrained optimization, elasticity, stock and flow as well as simultaneous equation models and differential equations were first introduced in natural sciences. These models entail the 2 From Theoretical Concepts to Operational Definitions and Procedures: Nominal Data and National Accounting
Home and Community‐Based Medicaid Options for Dependent Older Floridians

In an era of widespread state budget constraints, Florida has been increasingly challenged to provide long‐term care services to a growing population of older dependent persons. The high costs of nursing home care have led the state to implement care management alternatives that offer potential for cost savings along with greater consumer satisfaction through maintenance of community residence. Although these alternative care approaches represent important opportunities to contain costs, it is equally important that professional care providers and policymakers understand how such programs operate. Here the Florida experience with eight home and community‐based waiver models, in addition to the Program of All‐Inclusive Care for the Elderly, are summarized and a comparative analysis offered that may enlighten the efforts of other states to establish cost‐effective and attractive care management models.
Compatibility of Market Risk Measures

An important element of everyday financial decisions is to assess the scale of the risk of investing in various financial products. Knowledge on the degree of risk of the activities undertaken in this field allows a certain predictability about the negative effects that may occur. This is of great importance in the context of aversion to risk, and thus a better allocation of resources. A multitude of market risk measures is substantial and in addition they provide information about the risk of investment considered in a different perspective and form. A very interesting issue is the scale compatibility of these measures. It is important whether such measures to the same extent define the scale of risk and whether any signals about the dangers overlap in time. The above considerations based on the value at risk and so-caled RiskGrade have become a contribution to the creation of this publication.
High-Efficiency Class-E Power Amplifier With Shunt Capacitance and Shunt Filter

An analysis of a novel single-ended Class-E mode with shunt capacitance and shunt filter with explicit derivation of the idealized optimum voltage and current waveforms and load-network parameters with their verification by frequency domain simulations with 50% duty ratio is presented. The ideal collector voltage and current waveforms demonstrate a possibility of 100% efficiency. The circuit design with transmission lines at 2.14 GHz is discussed and analyzed. In order to reduce the voltage peak factor, the load network parameters can be rearranged to correspond to Class-E/F 3 mode by providing a short-circuit condition at the third harmonic when the second-harmonic tank is connected in series to the shunt filter. Broadband capability of a Class-E mode with shunt filter using reactance compensation technique has been demonstrated by two examples, one with lumped elements and the other with transmission-line elements. The test board of a transmission-line broadband Class-E GaN HEMT power amplifier with shunt filter was measured and high-performance results with the output power of around 41 dBm, average drain efficiency of 68%, and power gain of about 9 dB were achieved across the frequency band from 1.4 to 2.7 GHz.
Rapid tracheal infusion of surfactant versus bolus instillation in rabbits: effects on oxygenation, blood pressure and surfactant distribution.

UNLABELLED Surfactant bolus instillation may be associated with a drop in blood pressure. Platelet-activating factor (PAF) has been found in surfactant preparations. The aim of this study was to evaluate rapid tracheal infusion of surfactant during 5 min as an alternative to bolus instillation and to examine whether a PAF receptor antagonist is able to prevent the decrease in blood pressure. METHODS Surfactant deficiency was induced in 16 adult rabbits by lung lavages with saline. Six animals received a bolus of a porcine surfactant preparation (Curosurf (CS); 200 mg/kg), labeled with red microspheres to assess pulmonary distribution. In another 5 rabbits, the same amount of labelled CS was instilled by tracheal infusion within 5 min. A third group of 5 animals received 3 mg/kg body weight of the PAF antagonist WEB 2170 before CS bolus instillation. RESULTS After CS bolus administration, mean PaO2 increased by 44.7 +/- 8.3 kPa (mean +/- SD) within 2 min and remained at this level. Mean arterial blood pressure dropped transiently by 2.3 +/- 2 kPa within 5 min. Pulmonary distribution of surfactant was even. After infusion, mean PaO2 rose by 22.4 +/- 16.3 kPa within 15 min. Blood pressure dropped by 1.8 +/- 1.1 kPa within 15 min. The distribution was extremely uneven. Blood pressure decreases also occurred after pretreatment with PAF receptor antagonist. CONCLUSION Rapid tracheal infusion of surfactant results in poorer oxygenation, an inhomogeneous distribution and a similar decrease in blood pressure compared to the bolus instillation method. Blood pressure changes could not be prevented by a PAF receptor-specific antagonist.
Zone of Tolerance for Healthcare Services: A Diagnostic Model of Public and Private Hospital Service Quality

This study compares the quality of services provided by public and private hospitals in North Cyprus. The paper describes the zone of tolerance for patients’ service expectations and determines patient satisfaction level for public and private hospitals. The ‘zone of tolerance’ is recognized in the service-quality literature as representing a range of expectations (desired and adequate) and an area of acceptable outcomes in service interactions. The patient satisfaction level of public and private hospitals is identified and compared. The conceptual model, HEALTHZOT, is presented in this study and the results demonstrate that the evaluation of services can be scaled according to different types of expectations – ‘desired’ and ‘adequate’ – and that patients use these two types of expectations as a comparison standard in evaluating healthcare services. The results obtained for public and private hospital services represent a narrow zone of tolerance. Patients’ ‘perceived service received’ in public hospitals was lower when compared to private hospital services. The results of an exploratory factor analysis reveal that the SERVQUAL model is found to be unidimensional for both the public and private hospitals in this study. The results, managerial implications and future research implications are discussed below in detail.
What Do We Certainly Know About $\hbox{1}/f$  Noise in MOSTs?

1/f noise is a fluctuation in the conductance of semiconductors and metals. This noise could be a fluctuation in the number of free electrons or in their mobility. Many experimental studies have proved that the 1/f noise in homogeneous samples is a fluctuation in the mobility. There is a reliable empirical relation for the power density of the mobility noise. Theoretical models for mobility noise have not had much influence in the discussions. The theoretical position for number fluctuations is quite the opposite. The generally accepted McWhorter model is simple; however, very few experimental studies definitely prove number fluctuations and exclude uncorrelated mobility fluctuations. There is an extensive literature on noise in MOSTs. Submicrometer MOSTs are notorious for their high low-frequency noise. Almost all studies start from the McWhorter generation-recombination (GR) model. The discussion is confused by the many complications of the MOSTs, such as mobility degradation, surface and contacts effects, size of the samples, etc. An additional problem is that the real 1/f noise is often mixed up with other types of low-frequency noise, such as burst and GR noises. A critical discussion is given for the Kirton and Uren model. Analytical expressions are presented for the results of their computer simulations. This explains their surprising discovery that the density of McWhorter states may be ldquosubstantiallyrdquo different from the usual 1/ tau distribution.
Differences in osteoclast formation between proximal and distal tibial osteoporosis in rats with adjuvant arthritis: inhibitory effects of bisphosphonates on osteoclasts

Patients with rheumatoid arthritis commonly suffer both systemic and periarticular osteoporosis. Bisphosphonates (BPs) are inhibitors of bone resorption, and several derivatives have been developed for treatment of enhanced bone resorption. We aimed to characterize osteoclast formation in two different sites, the proximal tibial and distal tibial areas, in rats with adjuvant arthritis, and to investigate the impact of amino or non-amino types of bisphosphonate. Adjuvant arthritis was initiated in rats while administering daily injections of either etidronate, a non-amino BP, or alendronate, an amino BP, for 3 weeks. On the day following the last injection, bone mineral density (BMD) was measured in the proximal tibia to assess systemic osteoporosis and in the distal tibia for periarticular osteoporosis using dual-energy X-ray absorptiometry. Subsequently, bone marrow cells from either end of the tibia were collected and incubated for 7 days before staining and counting tartrate-resistant acid phosphatase positive cells. In the rats with adjuvant arthritis, BMD of either end of the tibia was lower than in normal rats. Although etidronate prevented bone mineral loss at both ends, distal loss was significantly less than proximal. In contrast, alendronate significantly inhibited mineral loss primarily in the proximal area. Large osteoclasts, defined as having five or more nuclei, formed preferentially in the proximal tibia, while small osteoclasts with fewer than four nuclei were found mainly distally. The suppressive effect of alendronate was greater on the large osteoclasts, while etidronate had a greater effect on the small osteoclasts. These results show that the size and multinuclearity of osteoclasts and the number of osteoclasts formed are different in the distal and proximal areas of the tibia, and that alendronate and etidronate may suppress different types of osteoclasts as discriminated by the number of nuclei.
Genome Analysis of Listeria monocytogenes Sequence Type 8 Strains Persisting in Salmon and Poultry Processing Environments and Comparison with Related Strains

Listeria monocytogenes is an important foodborne pathogen responsible for the disease listeriosis, and can be found throughout the environment, in many foods and in food processing facilities. The main cause of listeriosis is consumption of food contaminated from sources in food processing environments. Persistence in food processing facilities has previously been shown for the L. monocytogenes sequence type (ST) 8 subtype. In the current study, five ST8 strains were subjected to whole-genome sequencing and compared with five additionally available ST8 genomes, allowing comparison of strains from salmon, poultry and cheese industry, in addition to a human clinical isolate. Genome-wide analysis of single-nucleotide polymorphisms (SNPs) confirmed that almost identical strains were detected in a Danish salmon processing plant in 1996 and in a Norwegian salmon processing plant in 2001 and 2011. Furthermore, we show that L. monocytogenes ST8 was likely to have been transferred between two poultry processing plants as a result of relocation of processing equipment. The SNP data were used to infer the phylogeny of the ST8 strains, separating them into two main genetic groups. Within each group, the plasmid and prophage content was almost entirely conserved, but between groups, these sequences showed strong divergence. The accessory genome of the ST8 strains harbored genetic elements which could be involved in rendering the ST8 strains resilient to incoming mobile genetic elements. These included two restriction-modification loci, one of which was predicted to show phase variable recognition sequence specificity through site-specific domain shuffling. Analysis indicated that the ST8 strains harbor all important known L. monocytogenes virulence factors, and ST8 strains are commonly identified as the causative agents of invasive listeriosis. Therefore, the persistence of this L. monocytogenes subtype in food processing facilities poses a significant concern for food safety.