Miracle-dz/UniFAR-FTUs huggingface dataset:
Pulmonary function changes after different extent of pulmonary resection under video-assisted thoracic surgery.

Background Limited resections for early stage lung cancer have been of increasing interests recently. However, it is still unclear to what extent a limited resection could preserve pulmonary function comparing to standard lobectomy, especially in the context of minimally invasive surgery. The purpose of this study was to evaluate postoperative changes of spirometry in patients undergoing video-assisted thoracic surgery (VATS) lobectomy or limited resections. Methods Spirometry tests were obtained prospectively before and 6 months after 75 VATS lobectomy, 34 VATS segmentectomy, 15 VATS wedge resection. Eleven VATS mediastinal procedures without lung resection were taken as a control group. Results were compared between groups of different resection extent. Results Demographic characteristics and preoperative pulmonary function showed no differences among the four groups. Forced vital capacity (FVC) loss after lobectomy was significantly greater than after segmentectomy (P=0.048), and much significantly greater than after wedge resection (P<0.001). Forced expiratory volume in 1 second (FEV1) loss after lobectomy was similar to segmentectomy (P=0.273), both significantly greater than after wedge resection (P<0.01). Diffusing capacity of the lungs for carbon monoxide (DLCO) loss was similar among these three groups (P=0.293). There was no significant difference in any spirometry index between wedge resection and mediastinal procedures (FVC: P=0.856; FEV1: P=0.671; DLCO: P=0.057). When compared by average value per segment resected, pulmonary function loss was significantly less after lobectomy than after segmentectomy in all spirometry indexes (P<0.001). On average, pulmonary function loss was around 5% per segment for VATS lobectomy and 10% per segment for VATS segmentectomy. Conclusions In minimal invasive surgery, wedge resection best preserves pulmonary function with similar spirometry change with VATS mediastinal procedures without lung resection. Compared with VATS lobectomy, VATS segmentectomy may help minimize loss of FVC but not FEV1 or DLCO. Pulmonary function loss per segment resected is doubled after VATS segmentectomy than after lobectomy. These results should be taken into account when deciding the extent of resection for patients with early stage lung cancer.
Rainfall From Resolved Rather Than Parameterized Processes Better Represents the Present‐Day and Climate Change Response of Moderate Rates in the Community Atmosphere Model

Deficiencies in the parameterizations of convection used in global climate models often lead to a distorted representation of the simulated rainfall intensity distribution (i.e., too much rainfall from weak rain rates). While encouraging improvements in high percentile rainfall intensity have been found as the horizontal resolution of the Community Atmosphere Model is increased to ∼25 km, we demonstrate no corresponding improvement in the moderate rain rates that generate the majority of accumulated rainfall. Using a statistical framework designed to emphasize links between precipitation intensity and accumulated rainfall beyond just the frequency distribution, we show that CAM cannot realistically simulate moderate rain rates, and cannot capture their intensification with climate change, even as resolution is increased. However, by separating the parameterized convective and large‐scale resolved contributions to total rainfall, we find that the intensity, geographic pattern, and climate change response of CAM's large‐scale rain rates are more consistent with observations (TRMM 3B42), superparameterization, and theoretical expectations, despite issues with parameterized convection. Increasing CAM's horizontal resolution does improve the representation of total rainfall intensity, but not due to changes in the intensity of large‐scale rain rates, which are surprisingly insensitive to horizontal resolution. Rather, improvements occur through an increase in the relative contribution of the large‐scale component to the total amount of accumulated rainfall. Analysis of sensitivities to convective timescale and entrainment rate confirm the importance of these parameters in the possible development of scale‐aware parameterizations, but also reveal unrecognized trade‐offs from the entanglement of precipitation frequency and total amount.
IMPAIRED ANGIOGENESIS IN AGING MYOCARDIAL MICROVASCULAR ENDOTHELIAL CELLS IS ASSOCIATED WITH REDUCED IMPORTIN α AND DECREASED NUCLEAR TRANSPORT OF HIF1 α : MECHANISTIC IMPLICATIONS

of impaired angiogenesis with a focus on novel targets and mechanisms of VEGF gene activation - downregulation of importin α and impaired nuclear transport of HIF1 α . the Aging is associated with increased incidence of myocardial infarctions and impaired angiogenesis - new capillary blood vessel formation from preexisting vessels. The molecular mechanism(s) of aging-related impairment of angiogenesis are unknown. In the present study we focused on the mechanism of activation of the gene for vascular endothelial growth factor (VEGF - the most potent stimulator of angiogenesis) in young and aging myocardial microvascular endothelial cells (MMEC). Activation of VEGF gene in the cell nucleus is mediated in part by the transcription factor hypoxia-inducible factor 1 α (HIF1 α ). In order to activate VEGF gene, HIF1 α must first be transported to the nucleus, but the mechanisms of this transport are unknown. We hypothesized that reduced VEGF gene activation and impaired angiogenesis in myocardium during aging can result from downregulation of the nuclear transport receptor - importin α that leads to decreased transport of HIF1 α to the nucleus. We examined in MMEC isolated from young (3 months of age) and aging (24 months old) Fisher F-344 rats: 1) in vitro angiogenesis; and 2) the expression of VEGF, importin α and HIF1 α . Aging MMEC exhibited a 3.7-fold reduction in angiogenesis and a corresponding reduction in VEGF (by 3-fold) and importin α (by 1.9-fold) levels compared to young MMEC. Aging MMEC also exhibited cytoplasmic accumulation (by 1.8-fold) of HIF1 α protein, reduced HIF1 α transport to the nucleus and decreased binding of HIF1 α protein to the VEGF gene promoter. This study is the first demonstration of the downregulation of importin α in aging MMEC and reduced nuclear transport of HIF1 α , which likely lead to decreased VEGF gene activation and impaired angiogenesis. in the nucleus indicating impaired nuclear transport) and decreased transcriptional activation of the VEGF gene. We demonstrated that importin α binds to HIF1 α and therefore is involved in the transport of HIF1 α to the nucleus of endothelial cells and that during aging, importin α expression is reduced. In aging MMEC, the decreased importin α level likely impairs transport of HIF1 α to the nucleus, resulting in reduced VEGF gene activation and thereby significantly diminished angiogenic capability of the aging MMEC. Our findings demonstrate a potential mechanistic role of importin α as one of the major players in myocardial angiogenesis and also as a potential therapeutic target.
Ballroom Dancing Promotes Neural Activity in the Sensorimotor System: A Resting-State fMRI Study

Objective This study aims at investigating differences in the spontaneous brain activity and functional connectivity in the sensorimotor system between ballroom dancers and nondancers, to further support the functional alteration in people with expertise. Materials and Methods Twenty-three ballroom dancers and twenty-one matched novices with no dance experience were recruited in this study. Amplitude of low-frequency fluctuation (ALFF) and seed-based functional connectivity, as methods for assessing resting-state functional magnetic resonance imaging (rs-fMRI) data, were used to reveal the resting-state brain function in these participants. Results Compared to the novices, ballroom dancers showed increased ALFF in the left middle temporal gyrus, bilateral precentral gyrus, bilateral inferior frontal gyrus, left postcentral gyrus, left inferior temporal gyrus, right middle occipital gyrus, right superior temporal gyrus, and left middle frontal gyrus. The ballroom dancers also demonstrated lower ALFF in the left lingual gyrus and altered functional connectivity between the inferior frontal gyrus and temporal, parietal regions. Conclusions Our results indicated that ballroom dancers showed elevated neural activity in sensorimotor regions relative to novices and functional alterations in frontal-temporal and frontal-parietal connectivity, which may reflect specific training experience related to ballroom dancing, including high-capacity action perception, attentional control, and movement adjustment.
Anhedonia as a clinical correlate of inflammation in adolescents across psychiatric conditions

Abstract Objectives: Peripheral inflammation has been associated with multiple psychiatric disorders, particularly with depression. However, findings remain inconsistent and unreproducible, most likely due to the disorder’s heterogeneity in phenotypic presentation. Therefore, in the present study, in an effort to account for inter-individual differences in symptom severity, we utilised a dimensional approach to assess the relationships between a broad panel of inflammatory cytokines and key psychiatric symptoms (i.e. depression, anhedonia, anxiety, fatigue and suicidality) in adolescents across psychiatric disorders. We hypothesised that only anhedonia (reflecting deficits of reward function) will be associated with inflammation. Methods: Participants were 54 psychotropic medication-free adolescents with diverse psychiatric conditions and 22 healthy control (HC) adolescents, aged 12–20. We measured 41 cytokines after in vitro lipopolysaccharide stimulation. Mann-Whitney U and Spearman correlation tests examined group comparison and associations, respectively, while accounting for multiple comparisons and confounds, including depression severity adolescent. Results: There were no group differences in cytokine levels. However, as hypothesised, within the psychiatric group, only anhedonia was associated with 19 cytokines, including haematopoietic growth factors, chemokines, pro-inflammatory cytokines, and anti-inflammatory cytokines. Conclusions: Our findings suggest that general inflammation may induce reward dysfunction, which plays a salient role across psychiatric conditions, rather than be specific to one categorical psychiatric disorder.
Characterization of Aneurinibacillus aneurinilyticus Strain CKMV1 as a Plant Growth Promoting Rhizobacteria

A bacterial collection of approximately thirty native strains were isolated from rhizosphere soil associated with the seedlings of Valeriana jatamansi grown in moist temperate forest located in and around Chamba district of Himachal Pradesh. The strain CKMV1 showed PGP traits like, phosphate solubilization (257.0 mg l−1), indole acetic acid (7.0 μ gml−1) and siderophore production (53.43%) at 35±2oC. Besides, the strain also exhibited growth on nitrogen free medium, hydrogen cyanide production and antifungal activity against different fungal pathogens. Significant growth inhibition of fungal pathogens occurred in the order as S. rolfsii > R. solani > D. necatrix > Alternaria spp. > F. oxysporum. The results suggested that the rhizosphere of native V. jatamansi growing in their natural habitat of Chamba district of H.P. is a rich source of Bacillus sp. , which have potential to be used in the future as PGP inoculants to improve crop productivity. Morphological, biochemical and molecular based characterization of a selected isolate CKMV1, based on sequence homology of a partial 1375-bp fragment of 16S rDNA amplicon with the ribosomal database sequence validated the strain as Aneurinibacillus aneurinilyticus. Therefore, these results suggested that out of 30 isolates, Aneurinibacillus aneurinilyticus strain CKMV1 possessed multiple PGP traits thus can be further explored for its efficacy as effective PGPR.
Fracture Resistance of Ceramic Laminate Veneers Bonded to Teeth with Class V Composite Fillings after Cyclic Loading

Purpose Porcelain laminate veneers (PLVs) are sometimes required to be used for teeth with composite fillings. This study examined the fracture strength of PLVs bonded to the teeth restored with different sizes of class V composite fillings. Materials and Methods Thirty-six maxillary central incisors were divided into three groups (n=12): intact teeth (control) and teeth with class V composite fillings of one-third or two-thirds of the crown height (small or large group, resp.). PLVs were made by using IPS e.max and bonded with a resin cement (RelyX Unicem). Fracture resistance (N) was measured after cyclic loading (1 × 106 cycles, 1.2 Hz). For statistical analyses, one-way ANOVA and Tukey test were used (α=0.05). Results There was a significant difference between the mean failure loads of the test groups (P=0.004), with the Tukey-HSD test showing lower failure loads in the large-composite group compared to the control (P=0.02) or small group (P=0.05). The control and small-composite groups achieved comparable results (P > 0.05). Conclusions Failure loads of PLVs bonded to intact teeth and to teeth with small class V composite fillings were not significantly different. However, extensive composite fillings could compromise the bonding of PLVs.
Attentional Control and Retrieval Induced Forgetting Self-regulation Perspective

Retrieval Induced Forgetting (RIF) refers to the fi nding that the retrieval of some items from memory (RP+) impairs the retrieval of related items (RP-). The RIF effect is indicated by a comparison of RPwith unrelated but also tobe-remembered items (NRP). Since RIF appears during intentional memorizing of words, therefore we checked whether it depends on attentional control (AC) involved in goal maintenance, and also if implicit evaluations of to-be-remembered (RP) contents moderate this process (causing e.g. inhibition). In three experiments, each including AC as the independent variable, we found AC to be related to the RIF effect. Only high but not low AC subjects showed the presence of RIF. The results of the affective priming procedure showed that implicit evaluations of NRP items moderate the relationship of high AC and the RIF effect. The explanation why temporarily devaluated NRP could enhance the RIF effect and suggestion concerning future research summarize the article.
Osteology and skeletal development of Pyxicephalus adspersus (Anura: Ranidae: Raninae)

Despite the abundance and diversity of neobatrachians, relatively few descriptions exist of their ontogenesis and skeletal development. Herein, the adult and larval skeleton and the ontogenesis of the skeleton of the African frog, Pyxicephalus adspersus (Ranidae: Raninae), are described on the basis of cleared and double‐stained, dry, and alcohol‐preserved specimens. In P. adspersus, the first elements that ossify are the neural arches of the pre‐ and postsacral vertebrae (Gosner Stage 35), followed by the parasphenoid, frontoparietals, and exoccipitals (beginning at Stage 36). Major modifications of the chondrocranium begin at approximately Stage 40. The skull of the adult P. adspersus is exostosed and hyperossified, with many of the dermal bones of the cranium fused and highly ornamented. The osteology of the adult P. adspersus is compared to the skeletal morphologies of Conraua alleni (Raninae), which represents an African ranine for which osteological descriptions exist, and Ceratophrys cornuta (Leptodactylidae), which represents a hyperossified anuran with convergent morphology and behavior. The larval morphology and development of P. adspersus is compared to those of Rana pipiens and R. temporaria, which have been described in relative detail. The sequence of ossification of elements is compared with those of R. pipiens and R. temporaria. This study includes a discussion of the morphology of the elements forming the orbit, as well as a survey of the distribution of several characters related to dentary tusks of other Asian and African ranids. J. Morphol. 240:49–75, 1999. © 1999 Wiley‐Liss, Inc.
The receptor protein tyrosine phosphatase PTPRJ negatively modulates the CD98hc oncoprotein in lung cancer cells

PTPRJ, a receptor protein tyrosine phosphatase strongly downregulated in human cancer, displays tumor suppressor activity by negatively modulating several proteins involved in proliferating signals. Here, through a proteomic-based approach, we identified a list of potential PTPRJ-interacting proteins and among them we focused on CD98hc, a type II glycosylated integral membrane protein encoded by SLC3A2, corresponding to the heavy chain of a heterodimeric transmembrane amino-acid transporter, including LAT1. CD98hc is widely overexpressed in several types of cancers and contributes to the process of tumorigenesis by interfering with cell proliferation, adhesion, and migration. We first validated PTPRJ-CD98hc interaction, then demonstrated that PTPRJ overexpression dramatically reduces CD98hc protein levels in A549 lung cancer cells. In addition, following to the treatment of PTPRJ-transduced cells with MG132, a proteasome inhibitor, CD98hc levels did not decrease compared to controls, indicating that PTPRJ is involved in the regulation of CD98hc proteasomal degradation. Moreover, PTPRJ overexpression combined with CD98hc silencing consistently reduced cell proliferation and triggered apoptosis of lung cancer cells. Interestingly, by interrogating the can Evolve database, we observed an inverse correlation between PTPRJ and SLC3A2 gene expression. Indeed, the non-small cell lung cancers (NSCLCs) of patients showing a short survival rate express the lowest and the highest levels of PTPRJ and SLC3A2, respectively. Therefore, the results reported here contribute to shed lights on PTPRJ signaling in cancer cells: moreover, our findings also support the development of a novel anticancer therapeutic approach by targeting the pathway of PTPRJ that is usually downregulated in highly malignant human neoplasias.
[Suicide risk associated with bullying and depression in high school].

INTRODUCTION Suicide risk is increasingly common among children and adolescents. There are no current and local studies of this reality in northern Peru. The objective was to determine whether suici de risk was associated with bullying and depression in high school students. PATIENTS AND METHOD An analytical cross-sectional study was carried out in a city in northern Peru, using validated surveys to measure suicide risk, bullying and depression. Statical association data were obtained using generali zed linear models. RESULTS Out of 289 schoolchildren, 20% was at suicide risk and had some type of depression. Among those on the upper tertile of the bullying scale, 38% had suicidal ideation, while those who were depressed, 63% had suicidal ideation. The frequency of suicide risk increased as a result of bullying score (aPR: 1.83, 95% CI: 1.13-2.99, p value = 0.015), being depressed (aPR: 3.32, 95% CI: 1.69-6.51, p value < 0.001), family history of suicide (aPR: 1.99, 95% CI: 1.55-2.56, p va lue < 0.001), the passive desire to die (aPR: 2.20, 95% CI: 1.86-2.61, p value < 0.001), have planned suicide at some point (aPR: 2.05, 95% CI: 1.60-2.64; p value < 0.001) and study in a private school (aPR: 1.16, 95% CI: 1.14-1.18, p value < 0.001); adjusted by gender and school location. Conclu sion: Mental health of schoolchildren was involved in many aspects, several of them associated with a higher frequency of suicide risk.
Serum procalcitonin levels in incisional surgical site infections requiring a secondary suture after cesarean sections

Abstract Purpose: Surgical site infections (SSIs) after cesarean section cause maternal morbidity and economic and emotional burdens on society. Our aim is to measure procalcitonin (PCT) levels in patients who developed incisional SSIs after cesarean section while also comparing PCT concentrations between patients who underwent a secondary suture and who did not require a secondary suture. Methods: Ninety-four patients who developed incisional SSI after cesarean section were enrolled in our study. At the time of admission, serum PCT, C-reactive protein (CRP), and white blood cell (WBC) counts were measured. The study population was grouped into two, based on the need of a secondary suture and the patients baseline blood tests were compared. Results: The mean serum CRP level was not significant among the groups; however, the median serum PCT level was significantly higher in patients who required a secondary suture (0.21 vs. 0.05 ng/ml, p ≤ .0001). Serum PCT levels were positively correlated with the length of hospital stay (r = 0.72, p = .0001). Area under the curve (AUC) for PCT in predicting the need of a secondary suture was 0.85 (95% CI: 0.772–0.922) and the cutoff point was 0.142 ng/ml with a sensitivity of 75% and specificity of 97.8% (p = .0001). Conclusion: Serum PCT is a promising marker for both diagnosing and predicting the severity of SSIs after cesarean sections.
Holocene fluvial history of the Nile's west bank at ancient Thebes, Luxor, Egypt, and its relation with cultural dynamics and basin‐wide hydroclimatic variability

In the Theban area around modern Luxor (Egypt), the River Nile divides the temple complexes of Karnak and Luxor from New Kingdom royal cult temples on the western desert edge. Few sites have been archaeologically identified in the western flood plain, despite its presumed pivotal role in the ancient ritual landscape as the territory that both physically divided and symbolically connected the areas inhabited by the living and the areas occupied by the dead. Using borehole data and electrical resistivity tomography, the current investigation of subsurface deposits reveals the location of an abandoned channel of the Nile. This river course was positioned in the western, distal part of the Nile flood plain. Over 2100 ceramic fragments recovered from boreholes date the abandonment of the relatively minor river channel to the (late) New Kingdom. This minor river branch could have played an important role in the cultural landscape, as it would have served to connect important localities in the ritual landscape. Changes in the fluvial landscape match with established periods of basin‐wide hydroclimatic variability. This links cultural and landscape changes observed on a regional scale to hydroclimatic dynamics in the larger Nile catchment, in one of the focal areas of Ancient Egyptian cultural development.
Cardiovascular Risk Factors in a Suburban Community in Nigeria

The burden of hypertension, a silent killer, continues to increase in low- and middle-income countries. This study evaluated blood pressure (BP) in healthy adults to determine their risk of developing hypertension and to reduce associated morbidity of the disease. Overall, 182 subjects aged >16 years participated in the study. Systolic (SBP) and diastolic blood pressure (DBP) was measured after a resting period using mercury sphygmomanometer. Random blood glucose (RBG) concentration was also determined. Regression models were used to determine risk of high BP with p values < 0.05 indicating statistical difference. Prehypertension was present in 36.8% population and high BP in 31% individuals with hypertensive symptoms. DBP ≥ 90 mmHg was prevalent in the undiagnosed group, while diabetes comorbidity was detected in only 4 individuals. High BP or diabetes was not detected in those <20 year olds. Age > 35 years was an independent risk (likelihood ratio: 22.56, p < 0.0001); this increases to 26.48 (p < 0.0001) in the presence prediabetes and RBG > 100 mg/dl. Undiagnosed hypertension rate is high in the study area, and urgent interventions for large scale screening and management of the disease are required to reduce the burden of hypertension in Nigeria.