Miracle-dz/UniFAR-FTUs huggingface dataset:
Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance)

Purpose To determine the pathologic complete response (pCR) rate in estrogen receptor (ER) –positive primary breast cancer triaged to chemotherapy when the protein encoded by the MKI67 gene (Ki67) level was > 10% after 2 to 4 weeks of neoadjuvant aromatase inhibitor (AI) therapy. A second objective was to examine risk of relapse using the Ki67-based Preoperative Endocrine Prognostic Index (PEPI). Methods The American College of Surgeons Oncology Group (ACOSOG) Z1031A trial enrolled postmenopausal women with stage II or III ER-positive (Allred score, 6 to 8) breast cancer whose treatment was randomly assigned to neoadjuvant AI therapy with anastrozole, exemestane, or letrozole. For the trial ACOSOG Z1031B, the protocol was amended to include a tumor Ki67 determination after 2 to 4 weeks of AI. If the Ki67 was > 10%, patients were switched to neoadjuvant chemotherapy. A pCR rate of > 20% was the predefined efficacy threshold. In patients who completed neoadjuvant AI, stratified Cox modeling was used to assess whether time to recurrence differed by PEPI = 0 score (T1 or T2, N0, Ki67 < 2.7%, ER Allred > 2) versus PEPI > 0 disease. Results Only two of the 35 patients in ACOSOG Z1031B who were switched to neoadjuvant chemotherapy experienced a pCR (5.7%; 95% CI, 0.7% to 19.1%). After 5.5 years of median follow-up, four (3.7%) of the 109 patients with a PEPI = 0 score relapsed versus 49 (14.4%) of 341 of patients with PEPI > 0 (recurrence hazard ratio [PEPI = 0 v PEPI > 0], 0.27; P = .014; 95% CI, 0.092 to 0.764). Conclusion Chemotherapy efficacy was lower than expected in ER-positive tumors exhibiting AI-resistant proliferation. The optimal therapy for these patients should be further investigated. For patients with PEPI = 0 disease, the relapse risk over 5 years was only 3.6% without chemotherapy, supporting the study of adjuvant endocrine monotherapy in this group. These Ki67 and PEPI triage approaches are being definitively studied in the ALTERNATE trial (Alternate Approaches for Clinical Stage II or III Estrogen Receptor Positive Breast Cancer Neoadjuvant Treatment in Postmenopausal Women: A Phase III Study; clinical trial information: NCT01953588).
Good outcome in young adult schizophrenia.

Retrospective analysis was made of 13 young adult schizophrenics who had maintained good outcome from 2½ to 5½ years. Data was obtained from psychiatric history, discharge summary, therapist's progress notes, nursing notes, and follow-up questionnaire. Information was then compiled on onset and nature of psychosis, signs of early psychopathological condition, premorbid social functioning, clinical course, and follow-up. Though symptoms picture and duration of illness were variable, there was striking homogeneity in clinical course. Four phases were observed: (1) phase of internal disorganization, (2) phase of postpsychotic regression, (3) middle phase of postpsychotic regression, and (4) termination of regression. Features of these phases are described with suggestions for phase-appropriate management and therapy. Follow-up data indicates that most patients presently live alone and few have continued in intensive psychotherapy.
The Effect of Branding and Firm Size on the Recurrence of Food Recall Events Associated with Pathogenic Contamination in the United States

The Effect of Branding and Firm Size on the Recurrence of Food Recall Events Associated with Pathogenic Contamination in the United States. (May 2012) Montalee Kapilakanchana, B.S., Kasetsart University Chair of Advisory Committee: Dr. Victoria Salin Food recalls caused by pathogens receive considerable public attention due to health risk and the potential loss to the companies involved. There are very few studies analyzing the relationship between food recalls and characteristics of the companies involved. Because of the significance of the problem and lack of available research, the association between food recalls caused by pathogen and characteristics of the companies involved is examined in this thesis. To address the problem, data on food product recalls in the United States from January 2000 to October 2009 are used. Only the events caused by pathogens are analyzed in the thesis. The firms that have multiple recall incidents are the units of analysis. The study employs an econometric model with discrete choice modeling approaches: logit and probit. There are two main hypotheses. Firstly, it is hypothesized that branding decreases the likelihood of the occurrence of the repeated recall event. Secondly, size of the firm is hypothesized to be associated with higher likelihood of recurrence. The major finding is that branding and firm size are associated with higher probability of the
The relationship between service marketing mix, service quality, service value and customer satisfaction in commercial car parking facilities

The role of car park facilities in economic activities, properties market and human life is imperative. The population growth and vehicle possession in tandem with the rapid development of building construction to support commercial activities in cities with scarcity of parking space, have been well identified and have become a major concern in Malaysia. This phenomenon has raised several issues that affect the satisfaction of the Malaysian public as users of car park facilities. One of the recommended solutions was to have excellent parking services but why the Malaysian public is still not satisfied with how car park facilities are being managed is a puzzle. Based on the problem statement, this study focused on the relationships between service marketing mix, service quality, service value, and customer satisfaction of commercial car parking facilities in Malaysia. The study’s research framework was supported by the Stimulus-Organism-Response theory. Three of the four main constructs namely service marketing mix, service quality and service value were conceptualised as second order construct and assessed via the reflective-formative approach. Customer satisfaction which acted as a dependent variable was measured reflectively through six multi items. All the items in the study’s variables were assessed using the 7-point Likert scale. Data was derived from 182 car park customers who subscribed to monthly season passes from selected private offices in the Klang Valley. The response rate of 23%, was analysed using the SPSS and the SmartPLS software. This study found that the priority of mix elements were varied through the non-parametric Friedman Test and all direct relationships between service marketing mix, service quality, service value and customer satisfaction were found significant through the PLS-SEM methodology. Four indirect effect hypotheses to examine the role of service quality and service value as mediators were accepted as partial mediation. The study findings were discussed thoroughly and concluded with a discussion on the implications, the limitation of the study and recommendations for future study.
Stem cells from oral niches: a review.

AIM Stem cell research in recent years have been considered the most advanced sort of medical-scientific research and early results have aroused great expectations. Also in dentistry many studies were performed with the final aim of obtaining new bone and new teeth. In this work we describe the state of the art in dental science stem cell research. METHODS We have performed a web-based research on MEDLINE within (www.pubmed.gov). We have used "stem cells from human exfoliated deciduous teeth" (24 paper found), "periodontal ligament stem cells" (32 paper found), "stem cell apical papilla" (16 paper found), "dental pulp stem cells" (136 paper found) as keywords for research. For each keyword we have performed a complete review focusing on knowledge upgrade. RESULTS For each topic was created a selection of papers in chronological order of publication date so to give a timetable of the development of the research for each niche. CONCLUSION Research about stem cell from oral niches began in 2000 and every year papers publicated were more than the precedent. This review analysed about 180 articles most of which in the last 5 years. Dentla pulp from adult as from deciduous teeth seems to be the most valuable font of stem cells due to the pluripotential type of cells.
The Research on the Impact of Service Failure Severity on Customer Service Failure Attribution in the Network Shopping

In recent years, the rapid development of electronic commerce in China has made online shopping one of the most important shopping ways. However, there are more and more service failures on online shopping, and complaints about them are increasing, which will hinder the development of e-commerce in China. After service failure occurring, customers are going to decide the parties who are responsible for the failure typically based on specific failure situation and personal experience, namely service failure attribution. A lot of research has discussed the effect of service failure attribution on service recovery, customer satisfaction, trust and loyalty, as well as consumer intent of sequent behavior. And yet, the research on service failure attribution process is relatively less. Based on the literatures, this paper examines the effect of failure severity on service failure attribution of locus, controllability, and the moderating role of customer relationship and social responsibility image. The results of this study suggest that: Severity of failure has a significantly positive effect on service failure attribution of locus, controllability; Customer relationship significantly moderates the influences of failure severity on service attribution of locus, controllability; Social responsibility image significantly moderates the influences of failure severity on service attribution of locus, controllability.
Experience in providing genetic services in Costa Rica.

Costa Ricas medical genetics program began in the 1970s with the first medical genetics unit in the National Childrens Hospital. Currently Costa Rican medical genetic resources involve 3 institutions. The Hospital Nacional de Ninos is a childrens hospital with a clinical genetic service a cytogenetics laboratory and a biochemical genetics laboratory. Its clinical genetics service provides more than 2700 outpatient appointments 130 inpatient consultations and more than 50 inpatients each year. It also has the only clinical cytogenetics laboratory in the country with more than 375 karyotypes reported per year. The clinic has been disease-oriented since July 1991 and the clinical personnel includes 4 MDs and 2 cytogeneticists. The Genetics Unit of Instituto Costarricense Investigacion y Ensenanza en Nutricion y Salud (INCIENSA) provides newborn metabolic screening and a national registry of congenital malformations. The staff is comprised of 2 MDs 1 microbiologist and 1 statistician. The Universidad de Costa Rica has 2 independent units dedicated to human genetics: the molecular biology research unit and the other unit where a prenatal cytogenetics laboratory is operated with 1 cytogeneticist. This institute also has a population genetics unit that is focused on consanguinity studies and carrier detection. This system produces numerous reports on congenital malformations (information on malformed newborns from 24 hospitals out of 29 in the country) chromosomal abnormalities (a total of 4468 karyotypes were reported of which 648 or 14.5% were abnormal) newborn metabolic screening (it tests for phenylketonuria maple syrup urine disease and congenital hypothyroidism) and isolated Mendelian disorders that have allowed a preliminary diagnosis of the Costa Rican medical genetic disorders. Since 1990 in the hospital the care has been divided among 8 clinics that deal with: general genetics chromosomal disorders familial mental retardation genetic counseling syndromes and malformations skeletal dysplasia and connective tissue disorders inborn errors of metabolism and neurocutaneous syndromes. The result of 8-months effort to improve the quality of medical care is a decrease in the waiting list from 8 months to 5 months and a substantial reduction in hospital admissions.
PERAN ENVIRONMENTAL PERFORMANCE TERHADAP ENVIRONMENTAL DISCLOSURE DAN ECONOMIC PERFORMANCE

This study aimed to determine the effect of environmental performance on environmental disclosure andeconomic performance, and also the effect of environmental disclosure on economic performance. The data wastaken from the annual report of 2009-2011companies listed on the Indonesian Stock Exchange and participatingin PROPER. This study used multiple regressions. Environmental performance results showed there wasa significant positive effect on environmental disclosure, environmental disclosure and there was a significantpositive effect on economic performance, and the environmental performance did not significantly affect theeconomic performance. Environmental performance had indirect influence on economic performance.
Brand Experience: What is It? How is it Measured? Does it Affect Loyalty?

Brand experience is conceptualized as sensations, feelings, cognitions, and behavioral responses evoked by brand-related stimuli that are part of a brand's design and identity, packaging, communications, and environments. The authors distinguish several experience dimensions and construct a brand experience scale that includes four dimensions: sensory, affective, intellectual, and behavioral. In six studies, the authors show that the scale is reliable, valid, and distinct from other brand measures, including brand evaluations, brand involvement, brand attachment, customer delight, and brand personality. Moreover, brand experience affects consumer satisfaction and loyalty directly and indirectly through brand personality associations.
Metodología para elaborar un plan de mejora continua

espanolEl presente articulo desarrolla el tema titulado “Metodologia para Elaborar un Plan de Mejora Continua”, este trata de un conjunto de acciones planeadas, organizadas, integradas y sistematizadas para obtener cambios, y mejoras de procedimientos en la organizacion. La metodologia consta de cinco niveles: analisis de las causas que provocan el problema, propuesta y planificacion del plan de mejora, implantacion y seguimiento continuo, y finalmente una evaluacion de toda la metodologia aplicada; estas acciones proporcionaran beneficios a la organizacion como reduccion de costes, incremento de la productividad, mejora de la calidad, satisfaccion del cliente, una adecuada comunicacion entre los departamentos y mayor nivel productivo EnglishThe present article develops the theme entitled "Methodology for Developing a Continuous Improvement Plan", which deals with a set of actions planned, organized, integrated and systematized to obtain changes and improvements in procedures in the organization. The methodology consists of five levels: analysis of the causes that cause the problem, proposal and planning of the improvement plan, implementation and continuous monitoring, and finally an evaluation of the methodology applied; These actions will provide benefits to the organization such as cost reduction, increased productivity, improved quality, customer satisfaction, proper communication between departments and higher level of production
Quality Attributes of Various Spray Dried Pulp Powder Prepared from Low Temperature Stored Calcium Salts Pretreated Guava Fruits

The effect of calcium salts on the storage stability and on the quality attributes of both fresh and processed product (guava powder) of white flesh guavas (var ‘Allahabad safeda’) was studied. The pulp behavioral studies of fully ripened guava fruits indicated that fruits pretreated with 3% and 4.5% calcium chloride had the least viscosity. The guava pulp powder using spray drying technique was developed and its storage stability and the moisture sorption studies were carried out for product quality evaluation at normal storage condition (27°C; 65%RH). Results revealed that powder obtained from 3% calcium chloride pretreated guavas was found to be at par with the powder obtained from control guavas after 90 days of normal storage. Studies on microbiological quality of guava pulp powder indicated that among the treatments powder obtained from guava fruit pretreated with 3% calcium chloride to be the most effective through restricting microbial counts of total plate count, yeast, mold, Staphylococcus and E. coli below their permissible limit. Moisture sorption studies of guava powder revealed that foil laminate 12μm PET/9 μm foil/38-40 μm is the most suitable packaging material recommended. Keywords—White flesh guava, calcium salts, spray drying, powder, storage stability.
Effective Competitive Strategies of U.S. In Vitro Device Manufacturers

Effective Competitive Strategies of U.S. In Vitro Device Manufacturers by Sofia Beglari MS, TA University of Technology, 1997 BS, TA University of Technology, 1994 Doctoral Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Business Administration Walden University October 2017
SynopSIS: integrating physician sign-out with the electronic medical record.

BACKGROUND Safe delivery of care depends on effective communication among all health care providers, especially during transfers of care. The traditional medical chart does not adequately support such communication. We designed a patient-tracking tool that enhances provider communication and supports clinical decision making. AIM To develop a problem-based patient-tracking tool, called Sign-out, Information Retrieval, and Summary (SynopSIS), in order to support patient tracking, transfers of care (ie, sign-outs), and daily rounds. SETTING Tertiary-care, university-based teaching hospital. PROGRAM DESCRIPTION SynopSIS compiles and organizes information from the electronic medical record to support hospital discharge and disposition decisions, daily provider decisions, and overnight or cross-coverage decisions. It reflects the provider's patient-care and daily work-flow needs. PROGRAM EVALUATION We plan to use Web-based surveys, audits of daily use, and interdisciplinary focus groups to evaluate SynopSIS's impact on communication between providers, quality of sign-out, patient continuity of care, and rounding efficiency. CONCLUSIONS We expect SynopSIS to improve care by facilitating communication between care teams, standardizing sign-out, and automating daily review of clinical and laboratory trends. SynopSIS redesigns the clinical chart to better serve provider and patient needs.
Interest rate risk management and Islamic Banking: Evidence from Malaysia

The fluctuation of interest rate in the market has let the Islamic banks becoming more cautious and taking a step ahead in managing good risk management practices. This is an important element when a country adapts a dual banking system. The interest rate is obviously prohibited in Islam; however, it does not mean that the Islamic banks will not encounter any risk due to the interest rate fluctuation in the market. This is due to the nature of the Islamic banking balance sheet where it is fixed on asset side whereas in the conventional banking it looks more flexible to the asset, thus putting the Islamic banks unable to react expeditiously to the fluctuation in market interest rate which later leads to greater exposure to the rate of return risk. Therefore, the present study aims to investigate the effect of the interest rate risk towards the portfolios of the Islamic banks operating in the Malaysia. The quantitative result reveals that the majority of the Islamic banks are exposed to the interest rate risk and it is explained by the financial and economic variables. This study is expected to add value to the existing literature in risk management by proposing policy recommendations and methodological innovation.
In‐vitro Permeability to Salicylic Acid of Human, Rodent, and Shed Snake Skin

Abstract— In‐vitro permeability to salicylic acid of human, rodent, and shed snake skin has been examined for the purpose of selecting model membranes for human skin corresponding to different anatomic sites, since a marked regional variation is suggested among the different sites. The greatest permeability to salicylic acid was observed in the scrotum, that of the sole was negligible. The cheek, neck, and inguinal skin seemed more permeable than the breast, back, thigh, lower leg, or foot skin. Shed snake and skin of hairless rat were found to show similar permeability to human breast and thigh skin. Wistar rat and nude mouse skin showed similar permeability to human cheek, neck, and inguinal skin.
Daily Winners and Losers

One of the most salient events for a stock is being a daily winner or loser: these stocks are highlighted prominently in the media, leading to investor attention spikes. We demonstrate that ranked stocks underperform unranked stocks by over 1.50% during the month after the ranking. To establish causality, we introduce an identification strategy that exploits unconventional return-measurement periods. We provide a new attention-based solution for the idiosyncratic volatility puzzle and related return patterns, and thus a simple unifying explanation for important asset pricing anomalies.
Ethnic Capital and Intergenerational Mobility

Assuming that ethnicity acts as an externality in the human capital accumulation process, this chapter analyzes the extent to which ethnic skill differentials are transmitted across generations. The skills of the next generation depend on parental inputs and on the quality of the ethnic environment in which parents make their investments, or “ethnic capital. ” The empirical evidence reveals that the skills of today's generation depend not only on the skills of their parents, but also on the average skills of the ethnic group in the parents’ generation.
SNP genotyping for detecting the ‘rare allele phenomenon’ in hybrid zones

Hybrid zones are regions where genetically distinct populations meet, mate and produce offspring. In such zones, genetically less compatible gene combinations are usually generated, resulting in reduced fitness, and hybrid zones are often maintained because of continuous removal of unfit genotypes, balanced by gene flow into the zone from the parental populations (and are then referred to as ‘tension zones’). Tension zones often display unexpectedly high frequencies of gene variants that are rare outside the zone. Previous work has shown that this ‘rare allele phenomenon’ is not the result of intragenic recombination or increased mutation rates. Further understanding of the population genetics of the phenomenon requires an approach in which both the numbers of individuals and the numbers of loci is increased. Here, we report an approach using a combination of Illumina next‐generation sequencing and mass spectrophotometer genotyping to identify markers that may be used for genome‐wide investigations of the rare allele phenomenon. We test this approach on a hybrid zone in the land snail Albinaria hippolyti from Greece.
Target registration and target positioning errors in computer‐assisted neurosurgery: proposal for a standardized reporting of error assessment

Assessment of errors is essential in development, testing and clinical application of computer‐assisted neurosurgery. Our aim was to provide a comprehensive overview of the different methods to assess target registration error (TRE) and target positioning error (TPE) and to develop a proposal for a standardized reporting of error assessment.