Miracle-dz/UniFAR-FTUs huggingface dataset:
Patient satisfaction 8–14 years after dental implant therapy – a questionnaire study

Abstract Objective: The aim of this questionnaire study was to investigate patient satisfaction 8–14 years after dental implant therapy and complications influencing the degree of satisfaction. Materials and methods: A questionnaire was sent by post to 587 patients at a specialist clinic of periodontology. The questionnaire consisted of 19 statements or questions such as the degree of satisfaction with the implants and knowledge of complications. In nine of the questions, respondents were asked to grade the extent of their agreement with a statement by selecting from fixed answers. Three of the questions were designed to be answered using a visual analog scale. Results: In total, 400 individuals (81%) responded to the questionnaire. The mean time elapsed since implant installation was 10 years. A great majority (81%) experienced a high chewing comfort and was satisfied or sufficiently satisfied (94%) with the aesthetic aspects of their implant restorations, while 32% of the individuals had experienced problems with their implant reconstructions. The disadvantage that patients remarked on was the cost of the treatment. Those who had experienced problems with their implant reconstructions were also less satisfied with the treatment. Conclusion: A great majority of the patients expressed a high degree of satisfaction with their dental implants 8–14 years after the treatment. Patients were less satisfied if they had experience of problems with their implant reconstructions and in cases when the clinicians were unable to resolve their complications.
[Polyglandular autoimmune syndrome type II: epidemiology and forms of manifestation].

BACKGROUND AND OBJECTIVE Polyglandular autoimmune syndrome (PAS), is characterized by the coexistence of several autoimmune diseases, affecting predominantly the endocrine glands. The juvenile form (PAS type I) is distinguished from the adult type II in which autoimmune thyroiditis, adrenal cortical insufficiency and diabetes mellitus type I predominate. The connections between epidemiological, clinical and immunological aspects were analysed and described in this study of patients with PAS type II. PATIENTS AND METHODS Among a total patient population of over 15,000 seen in our endocrinological university policlinic from 1992 through 1996, the clinical data of all 151 patients with PAS type II were analysed retrospectively. RESULTS Of the 151 patients with PAS 37 were male (aged 16-74 years, median 42 years) and 114 female (aged 16-84 years; median 46 years), a prevalence of 1:100, 92 patients (61%) had diabetes mellitus type I (78% males, 55% females; p = 0.013), 50 (33%) had hyperthyroidism (32% and 33%; difference not significant), 49 had Hashimoto's thyroiditis (14% and 39%; p = 0.005) and 28 (18.5% had Addison's disease (14% males, 20% females; n.s.). Vitiligo was less common, occurring in 30 (20%), alopecia in 9 (6%), pernicious anaemia in 5 (5%) and hypogonadism in 8 (5%). The most common combination was diabetes type I with thyroiditis (33%), the time between manifestations of each disease being highly variable, diabetes was the first manifestation in half the cases. Partial cell antibodies were present in 62 patients (54%), and 52% had positive thyroid-associated antibodies without manifest signs of thyroid disease. CONCLUSION PAS occurs relatively often among patients of an endocrinological centre, with a 3:1 female to male ratio. Because there is usually a long interval between the onset of the various endocrine diseases, regular monitoring of patients with an endocrine autoimmune disease is indicated, specific tests to be performed if additional immune diseases are suspected.
Effect of upstream reading frames on translation efficiency in simian virus 40 recombinants

In a previous report (S. Subramani, R. Mulligan, and P. Berg, Mol. Cell. Biol. 1:854-864, 1981), it was shown that mouse dihydrofolate reductase (DHFR) could be efficiently expressed from simian virus 40 recombinant viruses containing the DHFR cDNA in different locations in the viral late region. This was true even in the case of the SVGT7dhfr26 recombinant, which had the DHFR coding sequence 700 to 800 nucleotides from the 5' end of the mRNA, where it was preceded by the VP2 and VP3 initiator AUGs and a number of other noninitiator AUGs. To investigate the process of internal translation initiation in mammalian cells, we constructed a series of SVGT7dhfr recombinants in which the upstream VP2 and VP3 reading frame was terminated in various positions relative to the DHFR initiation codon. The efficient production of DHFR in infected CV1 cells depended on having the terminators of the VP2-VP3 reading frame positioned upstream or nearby downstream from the DHFR initiation codon. These results reinforce the notion that mammalian ribosomes are capable of translational reinitiation.
Investigation into the Presence of Insulin‐degrading Enzyme in Cultured Type II Alveolar Cells and the Effects of Enzyme Inhibitors on Pulmonary Bioavailability of Insulin in Rats

The purpose of this study was to investigate the role of insulin‐degrading enzyme (IDE, EC 3.4.22.11) in insulin degradation in alveolar epithelium. The primary culture of isolated rat type‐II pneumocytes was used for the in‐vitro characterization of IDE. Insulin was then administered intratracheally with various inhibitors to assess the improvement in its pulmonary bioavailability.
Incidence of rheumatoid arthritis in central Massachusetts.

OBJECTIVE To determine whether there is a secular decline in the incidence of rheumatoid arthritis (RA), as has been suggested by previous studies. METHODS In the absence of comprehensive data in the United States population, we estimated RA incidence in a health maintenance organization population from 1987 through 1990 and compared the rates with those in an earlier, similarly performed study from Rochester, Minnesota, which covered the years 1950 through 1974. RA estimates were based on our review of medical records of patients who had been diagnosed as having RA or related diseases during the period of January 1, 1987 through December 31, 1990. RESULTS Annual age-standardized incidence of classic or definite RA (according to the American College of Rheumatology [formerly, the American Rheumatism Association] 1958 criteria) in patients aged 18 or older was 22 per 100,000 in men and 60 per 100,000 in women. The incidence of RA increased with age, with a marked increase in women older than 50. CONCLUSION We found no secular change in RA incidence compared with the similarly ascertained historical data.
Psychosocial Correlates of Decision Certainty in Academic Major Selection of College Students.

CH A PTER I. IN I ROUUC 1 IO N . Overview . The Developmental Importance o f Major Selection . Indecision Studies: Historical Pe rspec tive . Higher Education Attendance and M atriculation . Decision M a k in g . The Harren Model o f Career Decision Making The Case for Decision C erta in ty . Theoretical Constructs . Conceptual Model Framing the S tudy . Rationale for IHilizing Psychosocial Variables. Self-Efficacy. Locus o f C on tro l . Distinction Between Self-Efficacy and Locus o f Control. Self-Appraisal Process. Decision C erta in ty . Commitment and Contentm ent. Statement o f the P ro b le m . Purpose o f the S tudy. Importance/Significance o f the S tu d y . Study V ariab les . Conceptual/Operational Definitions. Dependent Variable. Decision C erta in ty . Independent Variables. Self-Efficacy. Self-Appraisal P rocess. Locus o f Control . Research Hypotheses And Questions. Hypotheses and Rationales. Hypothesis 1: Self-Efficacy Beliefs and Decision Certainty. R a t iona le .
Effect of Peer Counselors on Breastfeeding Initiation, Exclusivity, and Duration Among Low-income Urban Women

This study examined the effect of support from trained peer counselors on breastfeeding initiation, duration, and exclusivity among low-income urban women. Training of counselors, under the supervision of a registered nurse certified in lactation, adapted education techniques from Paulo Freire to provide information about lactation management and other health care issues. The study compared infant feeding practices of women who planned to breastfeed and received support from counselors (counselor group, N=59) to women who requested counselors but, owing to inadequate numbers of trained counselors, did not have a counselor (No-counselor group, N=43). Women in the counselor group had significantly greater (p<.05) breastfeeding initiation (93 percent vs. 70 percent), exclusivity (77 percent vs. 40 percent), and duration (mean of 15 weeks vs. mean of 8 weeks) than women in the no-counselor group. The findings suggest that peer counselors, well-trained, and with on-going supervision, can have a positive effect on breastfeeding practices among low-income urban women who intend to breastfeed.
The Use of Extracorporeal Membrane Oxygenation Systems in Severe Accidental Hypothermia After Drowning: A Centre Experience

Cardiopulmonary failure because of drowning with accidental hypothermia (AH) remains a major task for emergency care physicians. In this case series, we describe our experience in nine patients with cardiopulmonary failure after drowning with AH less than 35°C, who were provided on an emergency basis with extracorporeal life support (ECLS) system or extracorporeal membrane oxygenation (ECMO). Conservative rewarming methods are not considered for this study. Preclinical conditions and protocols were gathered. Surgical reports and clinical data sets were collected. Median age was 24 years (range, 6–75 years). Six patients were male. Climatic conditions mostly showed cold to frosty weather. All cases had different preclinical rescue procedures. They reached the emergency department under cardiopulmonary resuscitation (CPR). Indications for ECLS were cardiac arrest, and in one case, pulmonary failure. Mean CPR duration was 60 min (range: 15–120 min). Before implantation, the median pH value was 6.9. Two patients could be successfully weaned from the systems. Cause of death was severe neurologic damage in six patients and cardiac failure in one patient. The use of ECLS/ECMO is a therapy option for a small range of patients with cardiopulmonary failure because of drowning with AH. Nevertheless, the interval of preclinical rescue remains extensively long.
Can sedentary adults accurately recall the intensity of their physical activity?

BACKGROUND Physical activity, in particular vigorous activity (i.e., > or =6 METs), lowers mortality from chronic diseases such as cardiovascular disease (CVD). The 7-Day Physical Activity Recall (PAR), a self-administered activity log (LOG), and heart rate monitoring (HR) were used to quantify activity patterns among sedentary adults. We hypothesized that individuals in this population could accurately estimate the duration, but not the intensity, of their activity. METHODS Sedentary adults (n = 94, 47.8 +/- 7.1 years) completed two PARs 1 week apart and underwent HR monitoring while completing a LOG for 1 day during the PAR assessment interval. RESULTS The relationship between PARs (kcal. kg(-1). day(-1) ) was significant (r = 0.80, 95% CI 0.68-0.87) among individuals (n = 63) reporting "typical" activity patterns and among all individuals (n = 94) reporting "typical" and "not typical" activity patterns combined (r = 0.44, 95% CI 0.26-0.59). Quantity of moderate activity was greater (P = 0.0001) on PAR and LOG compared to that measured by HR. Quantity of hard (vigorous) activity was also greater (P = 0.019) on LOG compared to that measured by HR. CONCLUSIONS Sedentary adults tend to overestimate the intensity of their activity, specifically for moderate activity. Furthermore, the aerobic capacity of our sedentary adult sample (about 7.3 METs) suggests that the definition of a threshold intensity level of activity necessary to reduce mortality from CVD should be reexamined, because a value of > or =6 METs appears to be too high in this population.
Late-Onset Idiopathic Scoliosis in Children Six to Fourteen Years Old. A Cross-Sectional Prevalence Study*

We performed a point-prevalence survey of 15,799 children, six to fourteen years old, who formed part of a prospective longitudinal study. Our purpose was to detect the prevalence of scoliosis and to investigate associated factors. On the basis of the initial screening, 934 children (5.9 per cent) were referred for additional clinical and radiographic examinations; 896 children returned for this second evaluation. A lateral spinal curve with a Cobb angle of more than 5 degrees was seen in 431 children (2.7 per cent of the 15,799 children). Only seventy-six children (0.5 per cent) had a curve that met our definition of idiopathic scoliosis (a curve of more than 10 degrees with concordant apical rotation). The point-prevalence rate was higher in girls, and it increased with age. The rate was 0.1 per cent (four of 5246) in the age-group of six to eight years, 0.3 per cent (sixteen of 5831) in the age-group of nine to eleven years, and 1.2 per cent (fifty-six of 4722) in the age-group of twelve to fourteen years old. With allowance for the fact that different definitions of idiopathic scoliosis have been used in earlier studies, our results suggest that the natural history of idiopathic scoliosis may be becoming more benign spontaneously.
A Confocal Laser Scanning Microscope investigation of different dental adhesives bonded to root canal dentine.

AIM To evaluate the resin-dentine interface of different adhesive systems and corresponding luting cements proposed for bonding fibre posts to root canal dentine. METHODOLOGY Fifty extracted maxillary canines and central incisors were used. After root canal treatment the teeth were randomly divided into five groups of 10 teeth each. Fibre posts were inserted with five different adhesive systems and corresponding luting cements. Group 1: Clearfil Core/New Bond (Kuraray), group 2: Multilink (Vivadent), group 3: Panavia 21/ED Primer (Kuraray), group 4: PermaFlo DC (Ultradent), and group 5: Variolink II/Excite DSC (Vivadent). The primer was labelled in each case with 0.1% Rhodamine B isothiocyanate (RITC). Each root was sectioned into 2 mm thick slices at 1, 4 and 7 mm below the cementoenamel junction. The resin-dentine interface was evaluated using a Confocal Laser Scanning Microscope; the thickness of the hybrid layer and the number of resin tags were measured. The statistical analysis was performed using nonparametrical tests for comparisons between groups; for overall comparisons the Kruskal-Wallis test was used. Intraindividual analysis within teeth was performed using a linear model. RESULTS The thickness (microm) of the hybrid layer of group 1 (5.45; SD 1.21), group 4 (3.36; SD 1.59), and group 5 (4.33; SD 1.19) was significantly higher than in the other groups (P < or = 0.05). The number of resin tags observed in group 1 was significantly higher than in groups 2-4 (P < 0.05), but did not differ from group 5. Each group showed significantly more resin tags in the coronal and in the central part of the root canal than in the apical part (P < 0.001). CONCLUSION Conditioning of the root canal dentine with phosphoric acid and the use of one- and two-bottle-bonding systems gave a thicker and more uniform hybrid layer with considerably more resin tags than observed after the use of 'self-etching' adhesives. This might provide a more durable bond of the post to root canal dentine.
Conceptualising the Other: Online discourses on the current refugee crisis in Cyprus and in Poland

Abstract Framed within cognitive linguistics, Critical Metaphor Analysis and social psychology, the present paper explores the dynamics of the online construction of the Other in the context of migration and current refugee crisis. Thematically, it scrutinizes online refugee- and migrant-related mainstream and social media discourses in two European countries, Cyprus and Poland, in 2015–2016. On the theoretical and methodological level, it looks at the constituted and constitutive nature of metaphorical conceptualisations of migrants/refugees, their axiological and emotional potential for threat construction, and thus impact on possible cognitive-affective attitudes of the host countries’ citizens. It is theorized here, in line with Conceptual Metaphor Theory, that the choices of particular metaphors and their frequency of usage are likely to influence the salience of issues among the public, activate certain moral evaluations and generate fear, thereby creating grounds for verbal and physical aggression targeted at the Other. The paper addresses the following questions: 1) How is the Other conceptualised as a THREAT in both physical and symbolic sense? 2) To what extent are particular metaphorical conceptualisations within the representation of migrants and refugees common to corpora from both countries and/or socio-cultural context dependent? 3) How can metaphors, including dehumanization, serve as a springboard for individual acts of prejudice, as well as systematic discrimination, and violence? The analysed data was collected within the European project C.O. N.T. A.C. T. , exploring various aspects of hate speech and hate crime in ten EU countries.
Antihistamine use and breast cancer risk

Antihistamines are structurally similar to DPPE, a tamoxifen derivative known to promote tumor growth, and to antidepressants. Animal experiments have linked certain antihistamines and antidepressants with enhanced tumor growth in mice. The few epidemiologic studies examining antihistamine use have not indicated an increased risk. In light of suggestive animal data, structural similarities between antihistamines and DPPE, the widespread use of antihistamines, and the lack of epidemiologic investigation into their use and breast cancer risk, it is important to examine this issue. Female cases aged 25–74 years, diagnosed 1996 to 1998, were identified through the Ontario Cancer Registry. Controls were a random, age‐matched sample of women. Cases (n=3,133) and controls (n=3,062) completed a mailed questionnaire that included questions about antihistamines used regularly (undefined), type and duration. Age‐adjusted odds ratio (OR) estimates and 95% confidence intervals (CIs) were obtained using logistic regression. Antihistamine users were at no increased risk for breast cancer (OR=0.93, 95% CI: 0.81, 1.06), and no trend in risk was observed for age starting or duration of use. Antihistamine users were at no increased risk. No confounding or effect modification was identified in multivariate modeling. Our findings do not support the hypothesis that women who use antihistamines are at a greater breast cancer risk than those who do not. © 2003 Wiley‐Liss, Inc.
Joint modeling quality of life and survival using a terminal decline model in palliative care studies

Palliative medicine is a relatively new specialty that focuses on preventing and relieving the suffering of patients facing life‐threatening illness. For cancer patients, clinical trials have been carried out to compare concurrent palliative care with usual cancer care in terms of longitudinal measurements of quality of life (QOL) until death, and overall survival is usually treated as a secondary endpoint. It is known that QOL of patients with advanced cancer decreases as death approaches; however, in previous clinical trials, this association has generally not been taken into account when inferences about the effect of an intervention on QOL or survival have been made. We developed a new joint modeling approach, a terminal decline model, to study the trajectory of repeated measurements and survival in a recently completed palliative care study. This approach takes the association of survival and QOL into account by modeling QOL retrospectively from death. For those patients whose death times are censored, marginal likelihood is used to incorporate them into the analysis. Our approach has two submodels: a piecewise linear random intercept model with serial correlation and measurement error for the retrospective trajectory of QOL and a piecewise exponential model for the survival distribution. Maximum likelihood estimators of the parameters are obtained by maximizing the closed‐form expression of log‐likelihood function. An explicit expression of quality‐adjusted life years can also be derived from our approach. We present a detailed data analysis of our previously reported palliative care randomized clinical trial. Copyright © 2012 John Wiley & Sons, Ltd.
Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

The up-regulation of phase II detoxifying and stress-responsive genes is believed to play an important role in cancer prevention, and many natural compounds have been shown to be potent inducers of these genes. Previous studies showed that the antioxidant responsive element (ARE), found in these genes, can be bound by the transcription factor Nrf2, and is responsive to the activation by chemopreventive compounds and by oxidative stress. In the present study, we investigated the roles of extracellular signal-regulated kinase (ERK) and c-Jun-NH2-kinase (JNK) in the regulation of phenethyl isothiocyanate (PEITC)–induced and Nrf2-dependent ARE activity and ARE-driven heme oxygenase-1 (HO-1) gene expression in PC-3 cells. ARE activity and HO-1 expression were strongly increased after treatment with PEITC. PEITC also increased the phosphorylation of ERK1/2 and JNK1/2 and caused release of Nrf2 from sequestration by Keap1, and its subsequent translocation into the nucleus. Importantly, Nrf2 was also translocated into the nucleus after transfection with ERK or JNK and that these activated ERK and JNK colocalized with Nrf2 in the nucleus. Activation of ERK and JNK signaling also resulted in the elevation of ARE activity and HO-1 expression. Importantly, PEITC-induced ARE activity was attenuated by inhibition of ERK and JNK signaling. In vitro kinase assays showed that both ERK2 and JNK1 could directly phosphorylate glutathione S-transferase–Nrf2 protein. Taken together, these results strongly suggest a model in which PEITC treatment of PC-3 cells activates ERK and JNK, which, in turn, phosphorylate Nrf2 and induce its translocation to the nucleus. Nuclear Nrf2 activates ARE elements and induces expression of stress-responsive genes, including HO-1. [Mol Cancer Ther 2006;5(8):1918–26]
A Disturbance in the Neuronal Insulin Receptor Signal Transduction in Sporadic Alzheimer's Disease

Disturbances of glucose and energy metabolism are hypothesized as pathogenetic factors in sporadic dementia of Alzheimer type (SDAT). Insulin and is receptors play an important role in the regulation of brain glucose metabolism and neuronal growth. In postmortem brain cortex in SDAT, the densities of brain insulin receptors were decreased compared to adult controls, but were increased in relation to aged controls. Tyrosine kinase activity, a signal transduction mechanism common to insulin and IGF-1 receptors, was reduced in SDAT in comparison to middle-aged and age-matched control groups. The data are consistent with a neurotrophic role of insulin in the human brain and an upregulation of insulin receptors is SDAT brain as a compensatory mechanism, possibly due to impaired signal transduction mechanism.
Asymptotically exact H2 guaranteed cost computation by means of a special parameter-dependent Lyapunov function

This paper deals with guaranteed, H2 norm computation for continuous-time uncertain linear systems in convex bounded domains. As main result, we show that a special choice for the parameter-dependent Gramian solution allows us to establish a convergent sequence of polynomially parameter-dependent linear matrix inequalities whose solutions are constant symmetric matrices parametrized in terms of an integer k. Then, we propose some linear matrix inequality relaxations to numerically compute the H2 guaranteed cost and we investigate the trade off between accuracy of the results and computational effort.