Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of anthropogenic activities on the water quality parameters of federal university of agriculture Abeokuta reservoir

The study aimed to investigate the impacts of land use types on surface water quality and to determine the various anthropogenic activities of the surface water flowing into the reservoir. Four sampling stations were selected around the study location and water samples collected biweekly from February to June 2013. The result showed that the water quality parameter varied during the study with temperature ranged between 26.88-31.440C, pH (6.82-7.98), alkalinity (6.66-14.5mg/l) and dissolved oxygen (DO) (3.94-6.82mg/l). Highest DO was observed at the reservoir. No significant difference (p<0.05) was observed in the values of alkalinity among the water bodies. Temperature was statistically similar (p>0.05) at three of the stations but significantly different (p<0.05) at the reservoir. The study concluded that water quality of the reservoir was adversely affected by human activities such as domestic runoff, agricultural runoff, and refuse dump as well as seasonality in the streams flowing into the FUNAAB reservoir.
Leptospira interrogans Lsa 23 protein recruits plasminogen , factor H and C 4 BP from normal human serum and mediates C 3 b and C 4 b degradation

Correspondence Ana L. T. O. Nascimento ana.nascimento@butantan.gov. br Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503-900, São Paulo, SP, Brazil Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Professor Lineu Prestes, 1730, 05508-900, São Paulo, SP, Brazil Instituto Adolfo Lutz, Avenida Doutor Arnaldo, 355, 01246-000, São Paulo, SP, Brazil Laboratório de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Avenida Professor Dr Orlando Marques de Paiva, 87, 05508-270, São Paulo, SP, Brazil
Fetal Nutrition and Adult Disease: Programming of Chronic Disease through Fetal Exposure to Undernutrition

The nutritional basis of the fetal origins of adult disease The early life origins of cardiovascular disease Associations between fetal growth and adult disease: are they causal? Associations between fetal and infant growth and non-insulin-dependent diabetes Associations between human obesity and growth restriction during intrauterine life Renal disease and fetal undernutrition Fetal programming of immune function Programming in the pre-implantation embryo
Cornea Hyperosmotic Stress – Induced TRPM 2 Channel Activation Stimulates NLRP 3 Inflammasome Activity in Primary Human Corneal Epithelial Cells

Citation: Zheng Q, Tan Q, Ren Y, et al. Hyperosmotic stress–induced TRPM2 channel activation stimulates NLRP3 inflammasome activity in primary human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2018;59:3259– 3268. https://doi.org/10.1167/ iovs.18-23965 PURPOSE. The purpose of this study was to determine whether either a hyperosmotic or oxidative stress induces NLRP3 inflammasome activation and increases in bioactive IL-1b secretion through transient receptor potential melastatin 2 (TRPM2) activation in primary human corneal epithelial cells (PHCECs).
Chapter 6 Word-based Items-and-processes ( WoBIP ) : Evidence from Hebrew morphology

In his seminal book A-Morphous Morphology, Anderson provides ample evidence supporting the item-and-process approach to morphology, whereby relations between words, and thus the derivation of one word from another is expressed in terms of processes. Although Anderson excluded Semitic languages from the paradigm, I argue in this paper for the advantage of item-and-process in the analysis of Modern Hebrew word relations. Under this approach, the word/stem is the base, and the putative consonant root is just a residue of phonological elements, which are lexically prominent as are consonants in non-Semitic languages. The empirical basis of the arguments is drawn from natural and experimental data of adult Hebrew as well as child Hebrew.
Analysis of Myocardial Collagen in Male and Female Spontaneously Hypertensive Rats

Each year, nearly 250,000 women will die of coronary heart disease, the leading cause of death for women in America. A major contributing factor to coronary heart disease is the onset of hypertension, or high blood pressure. Hypertension is characterized as pertaining to a blood pressure of 140/90 mmHg or greater, 90-95% cases of which have no directly identifiable cause. It has been estimated that 6% of the world’s deaths can be attribute to the effects of hypertension; these effects are systemic, and include damage to the brain, blood vessels, heart and kidneys. Most of these effects, however, often occur before the symptoms of hypertension actually arise, including arterial lesions of the brain, heart and kidneys, hyperinsulinemia, dyslipidemia, and elevated hematocrit levels. Much valuable research has been conducted in the past pertaining to hypertension, but with a deficiency in the area of gender studies with most research being performed exclusively on male test subjects. The present study simultaneously compares the effects of hypertension on both male, female, and ovariectomized female subjects, using the Spontaneously Hypertensive Rat (SHR) as a model. Collagen, which is the main focus of this study and the major ultrastructural protein in the heart, is quantitated using 2D-PAGE to analyze the differences in collagen density in male and female SHR hearts. It is our hypothesis that given the difference between male and female physiology, specifically the presence or absence of estrogen, that hypertensive effects will manifest differently between the sexes, in terms of collagen deposition and density in the cardiac architecture.
GENETIC PARAMETER ESTIMATES FOR PRODUCTION AND REPRODUCTION TRAITS IN DAIRY BUFFALOES 1

The objective of this study was to determine the genetic variation in milk production, milk components, and reproductive traits in dairy buffaloes. A total of 9,318 lactation records from 3,061 cows were used to estimate the heritability of milk yield (MY), fat percentage (%F), protein percentage (%P), lactation length (LL), calving interval (CI), and age at first calving (AFC), as well as genetic and phenotypic correlations between these traits. Covariance components were estimated by Bayesian inference in a multitrait animal model using the GIBBS2F90 program. Contemporary groups and number of milkings (1 or 2) were included as fixed effects, age of dam at calving (linear and quadratic effects) as a covariate, and additive genetic, permanent environmental, and residual effects as random effects. The heritability estimates (± standard deviation) were 0.24 ± 0.02, 0.34 ± 0.05, 0.40 ± 0.05, 0.09 ± 0.01, 0.05 ± 0.01, and 0.16 ± 0.04 for MY, %F, %P, LL, CI, and AFC, respectively. The genetic correlations between MY and %F, %P, LL, CI, and AFC were -0.29, -0.18, 0.66, 0.08, and 0.24, respectively. Milk production and milk components showed sufficient genetic variation to obtain genetic gains through selection. The genetic correlations between MY and milk components were negative, and thus, undesirable because efforts to increase MY may decrease milk quality. Reproductive traits had little genetic influence, indicating that improvement of management would be sufficient to obtain better performance.
ALtERNAtIVE EStIMAtES OF thE RELIAbILIty OF COLLEGE GRAdE POINt AVERAGES ARtICLE 130

The purpose of this paper is to explore differences in the reliabilities of cumulative college grade point averages (GPAs), estimated for unweighted and weighted, one-semester, 1-year, 2-year, and 4-year GPAs. using cumulative GPAs for a freshman class at a major university, we estimate internal consistency (coefficient alpha) reliabilities for the several GPAs. We compare these reliabilities to similar reliabilities found in the literature. Principal findings are that different cumulative GPAs have different degrees of reliability and that GPA reliability increases at a decreasing rate with number of semesters completed. understanding these differences in reliability has implications for how GPAs are used by institutional researchers in practical as well as theoretical studies. The literature review and methods of the study should be useful to the institutional researcher who undertakes an investigation that involves GPA reliability.
Simultaneous determination of the ratio of live , dead and adherent bacteria in the presence of various single-walled carbon nanotubes 1

Methods: This paper provides a simple experimental setup and a mathematical formulation for simultaneous determination of ratios of the live/dead and adherent/non-adherent bacteria based on impedance changes. This method is especially useful in case of colored samples where traditional optical methods fail. The usefulness of our method is demonstrated by analyzing the effect of single-walled carbon nanotubes bearing various functional groups exerted on Staphylococcus aureus bacteria.
NR 4 A 2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells

The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the adenocarcinoma cell lines AR42J and AGS-GR, which both possess the gastrin/CCK2 receptor. In vivo, NR4A2 is strongly expressed in the gastrin responsive neuroendocrine ECL cells in normal mucosa, whereas gastric adenocarcinoma tissue reveals a more diffuse and variable expression in tumor cells. We show that NR4A2 is a primary early transient gastrin induced gene in adenocarcinoma cell lines, and that NR4A2 expression is negatively regulated by inducible cAMP early repressor (ICER) and zinc finger protein 36, C3H1 type-like 1 (Zfp36l1), suggesting that these gastrin regulated proteins exert a negative feedback control of NR4A2 activated responses. FRAP analyses indicate that gastrin also modifies the nucleus-cytosol shuttling of NR4A2, with more NR4A2 localized to cytoplasm upon gastrin treatment. Knock-down experiments with siRNA targeting NR4A2 increase migration of gastrin treated adenocarcinoma AGS-GR cells, while ectopically expressed NR4A2 increases apoptosis and hampers gastrin induced invasion, indicating a tumor suppressor function of NR4A2. Collectively, our results uncover a role of NR4A2 in gastric adenocarcinoma cells, and suggest that both the level and the localization of NR4A2 protein are of importance regarding the cellular responses of these cells. Citation: Misund K, Selvik L-KM, Rao S, Nørsett K, Bakke I, et al. (2013) NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells. PLoS ONE 8(9): e76234. doi:10.1371/journal.pone. 0076234 Editor: DunFa Peng, Vanderbilt University Medical Center, United States of America Received May 5, 2013; Accepted August 21, 2013; Published September 27, 2013 Copyright: © 2013 Misund et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by the Norwegian Cancer Association and the Cancer Fund at St. Olavs Hospital, Trondheim, Norway. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist. * E-mail: Liv.Thommesen@ntnu.no
Identification of Etoricoxib Polymorphic Crystalline Form in Pharmaceutical Raw Materials

The determination of the spatial configuration of the compounds structures used in the production of drugs is of utmost importance due to the different physical characteristics that each have in their solid state and therefore the different qualities of each one for its use as pharmaceutical raw material. This study aimed to identify the polymorphic crystalline form of Etoricoxib raw material, a non-steroidal anti-inflammatory drug (NSAIDs) selective inhibitor of cyclooxygenase 2 (COX2) enzyme widely used in the present, which was done through four different instrumental analytical techniques: X-ray diffractometry, differential scanning calorimetry, thermogravimetry and infrared spectroscopy, comparing and studying the results obtained from the analysis with those found in the literature. Using the data obtained with these four techniques it was demonstrated that the study sample exists predominantly in the 1 anhydrous Etoricoxib form.
Ju n 20 14 Diameter critical graphs

A graph is called diameter-k-critical if its diameter is k, and the removal of any edge strictly increases the diameter. In this paper, we prove several results related to a conjecture often attributed to Murty and Simon, regarding the maximum number of edges that any diameter-k-critical graph can have. In particular, we disprove a longstanding conjecture of Caccetta and Häggkvist (that in every diameter-2-critical graph, the average edge-degree is at most the number of vertices), which promised to completely solve the extremal problem for diameter-2-critical graphs. On the other hand, we prove that the same claim holds for all higher diameters, and is asymptotically tight, resolving the average edge-degree question in all cases except diameter-2. We also apply our techniques to prove several bounds for the original extremal question, including the correct asymptotic bound for diameter-k-critical graphs, and an upper bound of ( 6 +o(1))n for the number of edges in a diameter-3-critical graph.
Optical Interconnects for Next Generation Data Centers

The current data center architectures based on blade servers and electronic packet switches face several problems, e.g., limited resource utilization, high power consumption and cost, when handling the rapidly growing of data traffic. Optical networks offering ultra-high capacity and requiring low energy consumption are considered as a good option to address these problems. This thesis presents new data center architectures based on optical interconnects and transmissions, and evaluates performance by extensive simulations. The first main contribution of the thesis is to introduce a passive optical top-of-rack interconnect (POTORI) architecture. The data plane of POTORI mainly consists of passive components to interconnect the servers within the rack. Using the passive components makes it possible to significantly reduce power consumption while achieving high reliability in a cost-efficient way. In addition, the POTORI’s control plane is based on a centralized controller, which is responsible for coordinating the communications among the servers in the rack. A cycle-based medium access control (MAC) protocol and a dynamic bandwidth allocation (DBA) algorithm are designed for the POTORI to efficiently manage the exchange of control messages and the data transmission inside the rack. Simulation results show that under realistic DC traffic scenarios, the POTORI with the proposed DBA algorithm is able to achieve an average packet delay below 10 μs with the use of fast tunable optical transceivers. The second main contribution of the thesis is to investigate rack-scale disaggregated data center (DDC) architecture for improving resource utilization. In contrast to the traditional DC with blade servers that integrate various types of resources (e.g., central processing unit (CPU), memory) in a chassis, the rack-scale DDC contains fully decoupled resources held on different blades, referred to as resource blades. The resource blades are required to be interconnected within the rack by an ultra-high bandwidth optical interconnect through the optical interfaces (OIs). A resource allocation (RA) algorithm is proposed to efficiently schedule the resources in the DDC for virtual machine requests. Results show that with sufficient bandwidth on the OIs, the rack-scale DDC with the proposed RA algorithm can achieve 20% higher resource utilization and make 30% more revenue comparing to the traditional DC.
Demonstration of a protective immune response in infectious salmon anaemia ( 1 SA )-infected Atlantic salmon

A protective immune response in intectious salmon anaemia (1SA)-infected Atlantic salmon Salmo salar L. was demonstrated. Atlantic salmon that had survived a n ISA infection 75 d previously were less susceptible to reinfection. Fish passively immunized with serum from fish that had recovered from ISA were found to be partly protected against ISA. Neutralizing activity of ISAconvalescent antiserum was demonstrated by mixing convalescent antiserum w ~ t h ISA-infective tissue homogenate and injecting this preparation into Atlantic salmon.
Identification of transcriptional targets of healthspan in adipose tissue and modulation by resveratrol

Although calorie restriction (CR) slows the aging process in diverse species, CR is not a pragmatic strategy to attenuate aging in free-living humans. Accordingly, there is growing interest in identifying CR mimetics—compounds that elicit the salutary effects of CR without a reduction in energy intake. Because increased white adipose tissue (WAT) is associated with accelerated onset of many age-associated diseases, and because a reduction of WAT is a consistent feature of CR, diet-induced changes in WAT bioactivity may be attractive targets for assessing the efficacy of CR mimetics. We analyzed gene expression datasets from WAT of obese mice and humans and found a significant modulation of 22 pathways indicating decreased mitochondrial function and an up-regulation of the immune response and lysosomal structure. The change with obesity was abrogated by long-term CR in WAT of both mice and rats for 13 of the 22 pathways. For those 13 pathways, consumption of the putative CR mimetic resveratrol both opposed the effect obesity and mimicked the effect of CR for 11 and 10 pathways in human and mouse adipose tissue, respectively. Numerous studies have shown that resveratrol delays diverse aspects of the aging process, suggesting that our observed transcriptional response in WAT is indicative of increased healthspan. We propose that these pathways may be used as a framework to screen for novel CR mimetics.
Trim 37-deficient mice recapitulate several features of the multi-organ disorder

Mulibrey nanism (MUL) is a rare autosomal recessive multi-organ disorder characterized by severe prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes. MUL is caused by loss-of-function mutations in TRIM37, which encodes an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family and having both peroxisomal and nuclear localization. We describe a congenic Trim37 knock-out mouse (Trim37) model for MUL. Trim37 mice were viable and had normal weight development until approximately 12 months of age, after which they started to manifest increasing problems in wellbeing and weight loss. Assessment of skeletal parameters with computer tomography revealed significantly smaller skull size, but no difference in the lengths of long bones in Trim37mice as compared with wildtype. Both male and female Trim37mice were infertile, the gonads showing germ cell aplasia, hilus and Leydig cell hyperplasia and accumulation of lipids in and around Leydig cells. Male Trim37 mice had elevated levels of follicle-stimulating and luteinizing hormones, but maintained normal levels of testosterone. Sixmonth-old Trim37 mice had elevated fasting blood glucose and low fasting serum insulin levels. At 1.5 years Trim37 mice showed non-compaction cardiomyopathy, hepatomegaly, fatty liver and various tumors. The amount and morphology of liver peroxisomes seemed normal in Trim37 mice. The most consistently seen phenotypes in Trim37 mice were infertility and the associated hormonal findings, whereas there was more variability in the other phenotypes observed. Trim37 mice recapitulate several features of the human MUL disease and thus provide a good model to study disease pathogenesis related to TRIM37 deficiency, including infertility, non-alcoholic fatty liver disease, cardiomyopathy and
Helicobacter pylori: resistance and treatment results in Finland

5 List of abbreviations 7 List of original publications 8 Introduction 9 Review of the literature 11 History 11 Helicobacter pylori infection 11 Bacteriology 11 Epidemiology 12 Antibiotic resistance 12 Metronidazole 12 Clarithromycin 14 Amoxicillin 16 Tetracycline 17 Fluoroquinolones 17 Rifabutin 17 Dual resistance to both metronidazole and clarithromycin 18 Secondary resistance 18 Helicobacter pylori and gastroduodenal diseases 18 Gastritis 18 Peptic ulcer 20 Malignancies 20 Dyspepsia 21 Diagnosis of Helicobacter pylori infection 22 Invasive tests 22 Noninvasive tests 26 Clinical use of the tests 28 Helicobacter pylori eradication therapy 29 Challenges in the therapy 29 Indications for eradication therapy 30 Test-and-treat 30 First-line therapy 31 Rescue therapies after a failure 33 Side effects of the eradication treatment 34 Benefits from the eradication therapy 34 Present study 37 Aims of the present study 37 Patients 38 Methods 41 Culture 41 Antibiotic Resistance 42 Serum Antibody determination 42 Questionnaires 42 Statistical analyses 43 Ethics 43 Results 44 Resistance 44 Results of the eradication therapies 46
MEASURING THE LINK BETWEEN INTERGENERATIONAL OCCUPATIONAL MOBILITY AND EARNINGS : EVIDENCE FROM 8 EUROPEAN COUNTRIE S N ° 2011-03 MARS 2011

This paper investigates the relationship between family background and earnings using relative social mobility to decompose residual background correlations, namely the effect of background on earnings left after controlling for background-related intervening factors. Using the European Union Survey on Income and Living Conditions for 8 countries, we first show that country differences in terms of intergenerational inequality concern residual background correlations and then decompose these correlations using changes in relative social positions. In immobile countries, we find that significant residual correlations are mainly driven by penalisation of upward mobility in the UK (glass ceiling) and by an insurance against downward mobility in Spain and Italy (parachute). In mobile countries, insignificant residual correlations mask heterogeneous returns to social mobility. While our findings for Southern countries hardly concur with human capital theory, the widespread emergence of glass ceiling effects appears to be consistent with this theory. JEL Classification: D31, J62, J24, J31