Miracle-dz/UniFAR-FTUs huggingface dataset:
The Large Seed Size of Domesticated Lima Beans Mitigates Intraspecific Competition among Seed Beetle Larvae

The domestication of beans has selected for larger seeds in cultivated plants compared to their wild relatives. This has not only resulted in an enhanced resource for humans, but also for the insects that feed on these seeds. Seed beetles that attack wild and cultivated seeds often lay several eggs on a single seed. We hypothesized that the larger seed size of domesticated beans will mitigate the competition among the larvae that hatch from these eggs, with important implications for their growth and survival. To test this we examined how seed size of wild and cultivated Phaseolus lunatus (lima bean) affect the performance of the Mexican bean weevil Zabrotes subfasciatus, an important pest of beans in Mexico. A negative correlation was found between the initial number of eggs on a seed and the weight of female beetles that emerged, but only for the much smaller wild seeds. Similarly, beetle survival was found to be negatively correlated with competition intensity only on wild seeds. Our results imply that by selecting for larger seeds, domestication of Phaseolus lunatus has reduced the intensity of intraspecific larval competition of Z. subfasciatus.
Characterization of a sporulation gene, spoIVA, involved in spore coat morphogenesis in Bacillus subtilis

Mutations in the spoIVA locus of Bacillus subtilis abolish cortex synthesis and interfere with the synthesis and assembly of the spore coat. We have characterized the cloned spoIVA locus in terms of its physical structure and regulation during sporulation. The locus contains a single gene capable of encoding an acidic protein of 492 amino acids (molecular weight, 55,174). The gene is transcribed from a sigma E-dependent promoter soon after the formation of the spore septum. A genetic test indicated that expression of spoIVA is only necessary in the mother cell compartment for the formation of a mature spore. This, together with the phenotypic properties of spoIVA mutations, would be in accord with the hypothesis that sigma E is only active after septation and in the mother cell compartment.
No evidence for lipid peroxidation in severe preeclampsia.

OBJECTIVE This study was undertaken to address the role of oxidative stress in preeclampsia. STUDY DESIGN We measured urinary 8,12-iso-iPF(2alpha)-VI, a chemically stable, free-radical catalyzed product, in a case control study of severe preeclampsia nested within the trial of Calcium for Preeclampsia Prevention. Cases included 29 women who developed severe preeclampsia and from whom urine had been obtained 10 to 20 weeks before the diagnosis of preeclampsia, 3 to 9 weeks before, and 1 day before through delivery. Controls did not develop hypertension or proteinuria and were matched to cases by center, gestational age at each of 3 corresponding urine collections, and date of enrollment. RESULTS Urinary 8,12-iso -iPF(2alpha)-VI did not differ significantly between cases and controls before or at diagnosis of preeclampsia, nor did it vary with gestational age. CONCLUSIONS These results call into question the importance of oxidative stress in the disease and the biochemical rationale for clinical trials of antioxidants to prevent and treat preeclampsia.
A Restrictive Theory of Agrammatic Comprehension

In this paper I propose a new, restrictive theory of Trace-Deletion in agrammatism. This theory subsumes the Trace-Deletion Hypothesis (TDH; Grodzinsky, 1984a,b, 1986, 1990), which maintains that traces are deleted from agrammatic representations and that a cognitive strategy augments the patients' performance. This claim accounts for the pattern of loss and sparing observed in these patients' comprehension of a wide variety of syntactic constructions and is thus important for our understanding of the neural representation of syntax. Yet there are reasons for revising the account and making it more precise, stemming from both recent empirical findings and new developments in the theory of syntax. The original TDH was based on observations of agrammatic comprehension of structures containing traces resulting from either NP- or Wh-movement. Nevertheless, heads (as opposed to phrasal projections) also move and leave traces behind. Head movement (of verbs, for instance) has come to play a central role in linguistic theory (which currently postulates a wider variety of empty categories than any previous theoretical framework). Recent findings suggest that verb movement is retained in agrammatism, indicating that a sweeping claim regarding the deletion of all empty categories is too strong. This motivates the first restrictive move, resulting in a theory that picks out a restricted set of traces--only those for which deficient performance is indeed observed. All other empty categories are left intact. Trace-Deletion is tied to theta-positions. The second restrictive move is motivated by two types of surprising asymmetries that have recently been discovered for agrammatic comprehenders: First, agrammatic comprehension on passives of psychological predicates provides an error pattern that distinguishes this construction from agentive passive, indicating that the deficit is tied to the thematic properties of the predicate: Second, asymmetries have been observed in agrammatic comprehension of questions and quantifiers. These findings motivate a modification of the augmentative strategy, whose domain of application is restricted to referential NPs. Thus, the new account amounts to the claim that only traces in theta-positions are deleted, and that the strategy applies to referential NPs alone. This, I argue, not only derives all the data precisely but is also conceptually superior to any previous account of agrammatism. Finally, I discuss the consequences of this account to linguistic theory, and to theories of brain/language relations.
Effects of Moderate Hypothermia on Constitutive and Inducible Nitric Oxide Synthase Activities After Traumatic Brain Injury in the Rat

Abstract: We investigated the effects of therapeutic hypothermia (30°C) on alterations in constitutive (cNOS) and inducible (iNOS) nitric oxide synthase activities following traumatic brain injury (TBI). Male Sprague–Dawley rats were anesthetized with 0.5% halothane and underwent moderate (1.8–2.2 atm) parasagittal fluid‐percussion (F‐P) brain injury. In normothermic rats (37°C) the enzymatic activity of cNOS was significantly increased at 5 min within the injured cerebral cortex compared with contralateral values (286.5 ± 68.9% of contralateral value; mean ± SEM). This rise in nitric oxide synthase activity was significantly reduced with pretraumatic hypothermia (138.8 ± 17% of contralateral value; p < 0.05). At 3 and 7 days after normothermic TBI the enzymatic activity of cNOS was decreased significantly (30 ± 8.4 and 28.6 ± 20.9% of contralateral value, respectively; p < 0.05). However, immediate posttraumatic hypothermia (3 h at 30°C) preserved cNOS activity at 3 and 7 days (69.5 ± 23.3 and 78.6 ± 7.6% of contralateral value, respectively; mean ± SEM; p < 0.05). Posttraumatic hypothermia also significantly reduced iNOS activity at 7 days compared with normothermic rats (0.021 ± 0.06 and 0.23 ± 0.06 pmol/mg of protein/min, respectively; p < 0.05). The present results indicate that hypothermia (a) decreases early cNOS activation after TBI, (b) preserves cNOS activity at later periods, and (c) prevents the delayed induction of iNOS. Temperature‐dependent alterations in cNOS and iNOS enzymatic activities may participate in the neuroprotective effect of hypothermia in this TBI model.
Organization of simple cell responses in the three-dimensional (3-D) frequency domain

Abstract The amplitude spectra of simple cells in areas 17 and 18 were estimated in two and three dimensions (2–D and 3–D) using drifting sinusoidal gratings. In 2–D, responses were sampled with 16 x 16 resolution in spatial and temporal frequency at the optimal orientation. In 3–D, responses were sampled with 12 x 12 x 10 resolution in spatial frequency, orientation, and temporal frequency. For 45/50 cells studied, the spatial attributes of the receptive fields (RFs) were independent of temporal frequency except for a scale factor. The five exceptions to this general finding could be described as follows: For four area 17 cells, responses in the null direction increased with temporal frequency, reducing direction selectivity. For one area 18 cell, the optimal spatial frequency increased with temporal frequency and vice versa. The 2–D discrete Fourier transform was applied to all of the estimated amplitude spectra assuming zero spatial and temporal phase. These transforms were compared with the results of first-order reverse correlations as described in the previous paper (McLean et al., 1994). Direction selective cells exhibited excitatory subregions that were obliquely oriented in space-time in both the raw correlation data and inverse transforms of the spectral data. The slopes of the subregions found in these two measures were highly correlated. Direction indices obtained from space and frequency domain measures were comparable. We demonstrate that the spectral response profiles of most simple cells are aligned with the coordinate axes in frequency domain. That is, they may be considered one-quadrant separable, suggesting that these cells are not velocity tuned per se, but are tuned for spatiotemporal frequency. The spectral bandwidth establishes the range of velocities to which these cells will respond. These findings are consistent with the one-quadrant separability constraint of linear quadrature models. We conclude that most simple cells perform as roughly linear filters in two dimensions of space and time.
Retrograde amnesia and consolidation: Anatomical and lesion considerations

The four papers in this issue of Hippocampus dealing with retrograde amnesia, together with relevant animal studies in the literature, are reviewed from the perspective of the anatomical location of the lesion and extent of damage to the brain. In order to evaluate the underlying damage in these and related prospective experimental studies, it is necessary to consider both the lesion techniques that were used as well as the care with which the resulting damage was determined. Both temporally graded and flat, ungraded retrograde amnesia have been reported, as well a lack of effects, following damage to structures in the medial temporal area. Most research has centered around damage to the hippocampus, but differences in selectivity of the lesions and behavioral testing procedures preclude any definite conclusions regarding the precise nature of the involvement of this structure. With a greater appreciation for the importance of the locus and extent of the damage, together with the kind of information being processed, it should be possible to obtain a better understanding of the neural substrates underlying retrograde amnesia. Hippocampus 2001;11:43–49. © 2001 Wiley‐Liss, Inc.
A Compact Dual-Band Orthogonal Circularly Polarized Antenna Array With Disparate Elements

A dual-band orthogonally and circularly polarized antenna array with disparate elements is presented. By using corner-truncated stacked patches as elements, both left hand circular polarization (LHCP) in 12 GHz band and right hand circular polarization (RHCP) in 14 GHz band are realized in a shared antenna aperture. Furthermore, by employing disparate elements, the coupling between the two bands is suppressed effectively inside the feed network, hence improving isolation. The measured results of a four-element array agreed well with the simulated ones, achieving isolation better than 20 dB in the dual bands, and a maximum gain of 13.2 dBic for the LHCP and 13.9 dBic for the RHCP. The proposed array can find applications in satellite communications.
Role of platelet-derived growth factor and vascular endothelial growth factor in obliterative airway disease.

RATIONALE Platelet-derived growth factor (PDGF) is an important smooth muscle cell mitogen, and vascular endothelial growth factor (VEGF) is a known angiogenic and proinflammatory growth factor. We hypothesized that specific therapy aimed at these growth factors might inhibit the development of experimental obliterative airway disease (OAD). METHODS In fully mismatched rat tracheal allografts, we used imatinib and PTK/ZK, either alone or in combination, to block PDGF and VEGF receptor protein tyrosine kinase (RTK) action, respectively. Prophylaxis was initiated at the time of transplantation. Early treatment was commenced on Day 7 during the inflammatory phase and late treatment on Day 14 during the fibroproliferative phase of OAD. No immunosuppression was administered. MEASUREMENTS AND MAIN RESULTS Prophylaxis with either PTK/ZK or imatinib alone significantly reduced OAD, and combined prophylaxis completely prevented its development. Early treatment with PTK/ZK and imatinib also effectively reduced the development of OAD. Late treatment failed to show significant efficacy. Blocking VEGF RTK action with PTK/ZK reduced the activation of allograft blood vessels and the number of lymph vessels in the allograft airway wall, and significantly diminished allograft inflammation, whereas PDGF blockade with imatinib inhibited the growth of smooth muscle cells in the proliferating lesion. CONCLUSIONS Combined prophylactic PDGF and VEGF RTK blockade completely prevents the development of OAD. Also, when early treatment with PTK/ZK and imatinib is commenced during the inflammatory phase of OAD development, it significantly attenuates the development of tracheal occlusion, suggesting that these drugs could potentially be used to treat bronchiolitis obliterans syndrome in its early phase.
Absenteeism, childcare and the effectiveness of pension reforms

Both economic and epidemiological literature have shown that perceived high strain at work and lack of social infrastructures are good predictors of sick leave. The latter is particularly relevant in countries where facilities for children and care services are scarce and women are asked to fill the gap. The Italian 2011 pension reform significantly restricted age and seniority requirements for retirement, especially for women in private employment. We investigated whether older Italian employed women reacted to the postponement of retirement by increasing their sick leave. The empirical analysis offers unequivocal evidence that this has indeed been the case, in particular, for low-income grandmothers living in regions with a poor supply of childcare services. Radical reforms risk losing some of their effectiveness if they are not accompanied by parallel measures designed to introduce the welfare provisions previously indirectly and inadequately provided by the pension system, such as care facilities.JEL codes: J26, J13, C33
Social-cognitive determinants of HIV risk-taking intentions among men who date men through the Internet

Abstract The present study was set up to investigate social-cognitive determinants of HIV-risk precautionary intentions among men who have sex with men (MSM), who meet sex partners on the Internet. Participants were enrolled through the major gay chat room in The Netherlands, www.chatboy. nl, and were asked to complete an online questionnaire. Theory of Planned Behaviour variables attitude, subjective norm, and perceived control explained 55% of the variance in intention to use condoms for anal sex with future e-dates. Adding descriptive norm, personal norm and anticipated regret explained 70%. Sexual fantasies and HIV-status had unique effects on intentions. Differences between high and lower intenders are presented. Limitations of the study are discussed and objectives for an intervention to promote condom use are given.
Interorgan ammonia metabolism in liver failure: the basis of current and future therapies

Hepatic encephalopathy complicates the course of both acute and chronic liver disease and its treatment remains an unmet clinical need. Ammonia is thought to be central in its pathogenesis and remains an important target of current and future therapeutic approaches. In liver failure, the main detoxification pathway of ammonia metabolism is compromised leading to hyperammonaemia. In this situation, the other ammonia‐regulating pathways in multiple organs assume important significance. The present review focuses upon interorgan ammonia metabolism in health and disease describing the role of the key enzymes, glutamine synthase and glutaminase. Better understanding of these alternative pathways are leading to the development of new therapeutic approaches.
Observed anomalous atmospheric patterns in summers of unusual Arctic sea ice melt

The Arctic sea ice retreat has accelerated over the last decade. The negative trend is largest in summer, but substantial interannual variability still remains. Here we explore observed atmospheric conditions and feedback mechanisms during summer months of anomalous sea ice melt in the Arctic. Compositing months of anomalous low and high sea ice melt over 1979–2013, we find distinct patterns in atmospheric circulation, precipitation, radiation, and temperature. Compared to summer months of anomalous low sea ice melt, high melt months are characterized by anomalous high sea level pressure in the Arctic (up to 7 hPa), with a corresponding tendency of storms to track on a more zonal path. As a result, the Arctic receives less precipitation overall and 39% less snowfall. This lowers the albedo of the region and reduces the negative feedback the snowfall provides for the sea ice. With an anticyclonic tendency, 12 W/m2 more incoming shortwave radiation reaches the surface in the start of the season. The melting sea ice in turn promotes cloud development in the marginal ice zones and enhances downwelling longwave radiation at the surface toward the end of the season. A positive cloud feedback emerges. In midlatitudes, the more zonally tracking cyclones give stormier, cloudier, wetter, and cooler summers in most of northern Europe and around the Sea of Okhotsk. Farther south, the region from the Mediterranean Sea to East Asia experiences significant surface warming (up to 2.4°C), possibly linked to changes in the jet stream.
The toxic effect of ketamine on SH‐SY5Y neuroblastoma cell line and human neuron

Ketamine used as an injectable anesthetic in human and animal medicine is also a recreational drug used primarily by young adults often at all night dance parties in nightclubs. The percentage of ketamine users has grown very fast in the last 5 years worldwide. However, this leads to the serious question of the long‐term adverse effects of ketamine on our nervous system, particularly the brain, because ketamine as an NMDA antagonist could cause neurons to commit apoptosis. Our study therefore aimed to find out the chronic effect of ketamine on neuron using prolonged incubation (48 h) of neuronal cells with ketamine in culture. Our results showed that differentiated neuronal cells were prone to the toxicity of ketamine but probably less susceptible than undifferentiated neuronal cells and fibroblasts. This suggested that the ketamine abuse would be harmful to many other organs as well as the brain. Our results also confirmed that the toxicity of ketamine is related to apoptosis via the Bax/Bcl‐2 ratio pathway and caspase‐3 in the differentiated neuronal cells. Therefore, long‐term ketamine treated cell or animal models should be sought to study this multiorgan effects of ketamine. Microsc. Res. Tech., 2010. © 2009 Wiley‐Liss, Inc.
Self-discrepancies, attentional bias and persecutory delusions.

BACKGROUND Persecutory delusions appear to involve abnormal attentional biases to threat-related information, particularly information related to the self. The present study aimed to investigate attentional biases to different types of perceived threat and changes in self-perception in response to exposure to such threat-related material. METHOD Discrepancies between actual self, ideal self and perceived others' self-representations were assessed in three groups of participants; 13 people experiencing persecutory delusions, 11 people in a psychiatric comparison group, and 13 in a non-psychiatric comparison group. An adaptation of the emotional Stroop task was then used as an experimental manipulation of attentional bias to five different types of threat (sociotropic, autonomic, physical, ego threats from others, and self-directed ego threats). Self-discrepancies were then again assessed. RESULTS Before administration of the emotional Stroop task, there were no significant differences between the groups in terms of their self-actual:self-ideal and self-actual:other-actual discrepancies. However, after the administration of the Stroop task, significant differences between the clinical groups were observed, mirroring significant reductions in self-actual:self-ideal discrepancies and significant increases in self-actual:other-actual discrepancies in the paranoid participants. CONCLUSIONS This paper is novel in repeating the assessment of self-discrepancies after the processing of threat-related information. These findings are consistent with Bentall, Kinderman, and Kaney's (1994) model of paranoid ideation and findings reported by Kinderman and Bentall (2000).
Transcatheter aortic valve implantation in the operating room: early experience

Objective Aortic stenosis is the most common valvular heart disease in the Western world and the proportion of patients unsuitable for conventional surgery is increasing as a result of aging and comorbidities. We report our early experience with transcatheter aortic valve implantation in high-risk patients with severe symptomatic aortic stenosis. Methods Transcatheter Edwards-SAPIEN valve implantation was attempted in 22 patients (80 ± 5 years) in whom surgical risk was deemed excessive because of older age, poor left ventricular function, comorbidities, or all. A retrograde transarterial approach was used in 15 cases. In seven cases, valve implantation was performed by transapical approach because of aortic or iliac artery tortuosity, or both, and stenosis. All procedures were performed without cardiopulmonary bypass. Rapid ventricular pacing was used to reduce cardiac output while delivering balloon-expandable prosthesis. Results One patient died because of aortic dissection during early catheterization maneuvers. In the remaining patients, procedural success was achieved in all cases. Successful valve replacement was associated with an increase in transthoracic echocardiographic valve area from 0.65 ± 0.14 to 2.2 ± 0.4 cm2 and significant improvement in clinical condition. During the course of this experience, we encountered three (13.6%) cases of vascular complications related to transcatheter aortic valve implantation procedures. Conclusion The present study confirms the excellent hemodynamic performances of the transcatheter-implanted aortic prosthesis, with both transarterial and transapical approaches, in inoperable candidates with end-stage aortic stenosis. With progressive improvement in patient selection, techniques, equipment, and operator endovascular skills, vascular complications can decline further.