Miracle-dz/UniFAR-FTUs huggingface dataset:
Posttransplant Lymphoproliferative Disorder among Renal Transplant Patients in Relation to the Use of Mycophenolate Mofetil

Background. The introduction of increasingly effective immunosuppressants has raised the question of whether posttransplant lymphoproliferative disorder (PTLD), a complication of immunosuppression, would become more frequent. This study assessed the risk of PTLD in relation to immunosuppression during a period that saw the introduction and eventual market dominance of mycophenolate mofetil (MMF). Methods. A case-control study was conducted at 23 U.S. transplant centers. All participants received a renal-only transplant on or after July 1, 1995. PTLD cases were reported by centers and confirmed by central review. The United Network for Organ Sharing (UNOS) supplemented case ascertainment and identified controls matched on center, transplant date, and age. Center personnel abstracted risk factor and therapy data for cases and up to four controls per case. Cases and controls were compared, using a matched multivariate analysis, to assess the impact of MMF as one component of triple-therapy adjusted for other drug therapies and known risk factors. Results. Data were collected for 108 PTLD cases and 404 controls. PTLD risk for individuals on triple therapy with MMF was similar to the risk experienced by individuals on triple therapy with no MMF (adjusted odds ratio = 1.19; 95% CI 0.55–2.55). There was no dose response relationship between MMF and PTLD risk. Conclusions. Use of MMF was not associated with an increase in PTLD among patients who received triple immunosuppressive therapy, but an excess in risk as large as 155% or a reduction in risk by as much as 45% cannot be ruled out.
RNA Polymerase II-Controlled Expression of Antigenomic RNA Enhances the Rescue Efficacies of Two Different Members of the Mononegavirales Independently of the Site of Viral Genome Replication

ABSTRACT De novo generation of negative-strand RNA viruses depends on the efficient expression of antigenomic RNA (cRNA) from cDNA. To improve the rescue system of Borna disease virus (BDV), a member of the Mononegavirales with a nuclear replication phase, we evaluated different RNA polymerase (Pol) promoters for viral cRNA expression. Human and mouse Pol I promoters did not increase the recovery rate of infectious BDV from cDNA compared to the originally employed T7 RNA polymerase system. In contrast, expression of viral cRNA under the control of an RNA Pol II promoter increased the rescue efficacy by nearly 20-fold. Similarly, rescue of measles virus (MV), a member of the Mononegavirales with a cytoplasmic replication phase, was strongly improved by Pol II-controlled expression of viral cRNA. Analysis of transcription levels derived from different promoters suggested that the rescue-enhancing function of the Pol II promoter was due mainly to enhanced cRNA synthesis from the plasmid. Remarkably, correct 5′-terminal processing of Pol II-transcribed cRNA by a hammerhead ribozyme was not necessary for efficient rescue of BDV or MV. The correct 5′ termini were reconstituted during replication of the artificially prolonged cRNA, indicating that the BDV and MV replicase complexes are able to recognize internal viral replication signals.
Electrocardiogram in Pneumocystis carinii pneumonia: Can it be used as a prognostic variable?

Objective Many prognostic variables have been studied in patients with Pneumocystis carinii pneumonia and acquired immunodeficiency syndrome (AIDS). The role of the electrocardiogram in this setting has not been previously evaluated. We analyzed the admission electrocardiogram in patients with Pneumocystis carinii pneumonia and AIDS in an attempt to identify electrocardiogram findings that could be associated with adverse clinical outcomes and worse prognostic variables. Design A retrospective medical chart review. Setting All confirmed cases of Pneumocystis carinii pneumonia in patients positive for human immunodeficiency virus admitted to Albert Einstein Medical Center from 1994 to 2000. Methods Patients were assigned increasing severity ranks based on the findings on the admission electrocardiogram (normal sinus rhythm, sinus tachycardia, and right ventricular strain pattern). Data were extracted regarding study outcomes (admission to intensive care unit, mechanical ventilation, and hospital mortality) and prognostic variables. Main Results Of the 40 study patients, 14 (35%) had normal sinus rhythm, 15 (37.5%) had sinus tachycardia, and 11 (27.5%) presented with signs of right ventricular strain. The number of admissions to the intensive care unit, use of mechanical ventilation, and hospital mortality rate all increased with the severity of the electrocardiogram findings (p ≤ .03). The serum lactate dehydrogenase concentrations and the alveolar-arterial oxygen gradient both increased with the severity of the electrocardiogram findings (p ≤ .02). Conclusion Electrocardiogram findings of sinus tachycardia and right heart strain are common in Pneumocystis carinii pneumonia. These findings are associated with adverse clinical outcomes as well as worsening of prognostic variables. The electrocardiogram may be useful in predicting outcome in patients with Pneumocystis carinii pneumonia.
Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors.

BACKGROUND Although intrinsic skeletal muscle abnormalities can influence exercise intolerance during heart failure (HF), the factors responsible for muscle changes have not been elucidated. In this study we evaluated the expression of myogenic regulatory factors (MRF), myosin heavy chain (MyHC) isoforms, and fiber trophism in the soleus muscle of rats with myocardial infarction-induced heart failure. METHOD/RESULTS Six months after surgery, 2 groups of rats were studied: sham, and infarcted rats with HF (MI/HF+, MI size: 41.1±6.3% of total left ventricular area). In the infarcted group, microscopic evaluation revealed scattered foci of fiber necrosis in combination with inflammatory cells, phagocytosis, and increased fibrous tissue. The frequency of necrotic fibers was significantly higher in the MI/HF+ group than in the sham. The MI/HF+ group had atrophy of type I, IC/IIC, and IIA fibers compared to the sham group (P<0.05). MyoD gene expression was higher in the MI/HF+ group (sham: 1.00±0.49; MI/HF+: 2.53±0.71 arbitrary units; P<0.001). Myogenin and MRF4 gene expression was similar in both groups. Myogenin protein levels were reduced in the MI/HF+ group (sham: 1.00±0.21; MI/HF+: 0.74±0.21 arbitrary units; P=0.026). MyoD and MRF4 protein levels, as well as the MyHC distribution, were not different between groups. The MI/HF+ group had higher TNF-α and IL-6 serum concentrations than the sham group. CONCLUSIONS Heart failure-induced skeletal muscle atrophy is combined with fiber necrosis, increased MyoD gene expression and decreased myogenin protein levels.
[Cigarette smoking, use of snuff and other risk behaviour among students].

BACKGROUND Different prevalences of cigarette smoking and use of snus between University students and non-students, may supply us with information about the diffusion stage of the epidemic. User characteristics and involvement in other risk behaviour influences their status as diffusion agents. MATERIAL AND METHODS 1 655 students at the University of Oslo responded to a postal questionnaire about their tobacco, alcohol and drug use, gambling habits, physical activity and incidence of anxiety and depression. Data on tobacco habits of similarly aged youth outside University were obtained from Statistics Norway. RESULTS The response rate was 57 %. The proportion of daily smokers was significantly lower among students (men [10 %], women [9.6 %]), than among non-students (men [27 %], women [28 %]). The proportion of snuff users (daily + occasionally) for women was almost three times higher among students (12 %) than non-students (3.8 %). For men the results were different (28 % snuff users among students and 33 % among non-students). The quit-rate for smoking among students was higher for daily (46 %) and former users (61 %) of snus, than among students who had not used snus (34 %). Cigarette smoking increased with drug abuse, alcohol consumption, physical inactiveness, reduced mental health, and absence of parity. Use of snus was a typical male phenomenon, and increased with alcohol consumption and drug abuse. INTERPRETATION The diffusion of the snus epidemic seems to be in an early stage for women, while for men it may already have reached a level of maturity. The high proportion of previous smokers among snus users, indicates that snus may affect the prevalence and frequency of smoking in a population. Groups with a low social impact seem to have a higher prevalence of smokers, both in general and among students, while the opposite is the case for snus users.
The epidemiology of anorexia nervosa in Denmark from 1973 to 1987: a nationwide register study of psychiatric admission

A nationwide register study of psychiatric admission for anorexia nervosa in Denmark yielded average incidence rates of 1.9 per 100,000 per year for females and 0.17 per 100,000 per year for males. The prevalence was 6.7 per 100,000 per year for females and 0.6 per 100,000 per year for males. The female‐male ratio for first admissions was 11.8: 1. The incidence of anorexia nervosa showed no trend in the general population, but an increase was found among psychiatric inpatients. This increase was explained by a reduction by one third in all psychiatric first admissions and in available psychiatric beds and augmented by an increase in readmissions of anorectic patients. Males were younger than females at first admission. Females were older at first admission from 1973 to 1977 than in later periods. Of males readmitted for non‐eating disorders, more were psychotics and fewer psychopaths than among females. Age‐period and age‐cohort analysis of the 10‐ to 24‐year‐old females showed that only age exerted a significant independent influence on first‐admission rates, whereas all 3 factors exerted significant independent influence on readmission rates. This might reflect changes in admission policy, greater diagnostic vigilance and changes in attitude towards weight, shape and fitness.
Heparan Sulfate Is a Selective Attachment Factor for the Avian Coronavirus Infectious Bronchitis Virus Beaudette

Abstract The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order to understand the acquired tropism of the Beaudette strain, we compared the S protein sequences of several IBV strains. The Beaudette strain was found to contain a putative heparan sulfate (HS)-binding site, indicating that the Beaudette virus may use HS as a selective receptor. To ascertain the requirements of cell-surface HS for Beaudette infectivity, we assayed for infectivity in the presence of soluble heparin as a competitor and determined infectivity in mutant cell lines with no HS or glycosaminoglycan expression. Our results indicate that HS plays a role as an attachment factor for IBV, working in concert with other factors like sialic acid to mediate virus binding to cells, and may explain in part the extended tropism of IBV Beaudette.
Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma.

PURPOSE The major cause of death in aggressive lymphoma is relapse or nonresponse to initial therapy. Lenalidomide has activity in a variety of hematologic malignancies, including non-Hodgkin's lymphoma (NHL). We report the results of a phase II, single-arm, multicenter trial evaluating the safety and efficacy of lenalidomide oral monotherapy in patients with relapsed or refractory aggressive NHL. PATIENTS AND METHODS Patients were treated with oral lenalidomide 25 mg once daily on days 1 to 21, every 28 days, for 52 weeks, until disease progression or intolerance. The primary end point was response; secondary end points included duration of response, progression-free survival (PFS), and safety. RESULTS Forty-nine patients with a median age of 65 years received lenalidomide in this study. The most common histology was diffuse large B-cell lymphoma (53%), and patients had received a median of four prior treatment regimens for NHL. An objective response rate of 35% was observed in 49 treated patients, including a 12% rate of complete response/unconfirmed complete response. Responses were observed in each aggressive histologic subtype tested (diffuse large B-cell, follicular center grade 3, mantle cell, and transformed lymphomas). Of patients with stable disease or partial response at first assessment, 25% improved with continued treatment. Estimated median duration of response was 6.2 months, and median PFS was 4.0 months. The most common grade 4 adverse events were neutropenia (8.2%) and thrombocytopenia (8.2%); the most common grade 3 adverse events were neutropenia (24.5%), leukopenia (14.3%), and thrombocytopenia (12.2%). CONCLUSION Oral lenalidomide monotherapy is active in relapsed or refractory aggressive NHL, with manageable side effects.
Clinical features and treatment outcome in Japanese patients with social anxiety disorder: Chart review study

Abstract The lifetime prevalence of social anxiety disorder (SAD) is high at 3–13%, but there have been only limited reports investigating the clinical features of this disorder in a large number of Japanese patients. The authors have conducted a retrospective, chart review study of 52 patients with SAD and obtained the following results. (i) The proportion of SAD in first visit outpatients at the Department of Psychiatry, Niigata University Medical and Dental Hospital, Niigata, Japan, was 1.04%. The male : female ratio was 1:0.73, so male patients appeared to be more common in the sample. (ii) With regard to subtype, generalized type (73% of the patients) was more common than non‐generalized type (27%). (iii) The mean age of onset was 18.6 ± 7.8 years, and there was a trend towards onset of disease at a younger age in the generalized type compared to the non‐generalized type. (iv) The most common chief complaint was anxiety and tension in front of others (40.4%). (v) Pharmacotherapy resulted in improvement in 63.5% of the patients. Treatment by fluvoxamine and alprazolam resulted in high response rates of more than 70%.
Ecology and genetic variation of Amblyomma tonelliae in Argentina

The ecology of Amblyomma tonelliae (Ixodida: Ixodidae), including its seasonal distribution and the development periods of each stage, was investigated during a study carried out over two consecutive years in northwestern Argentina. In addition, the genetic variation of this tick was studied through analyses of 16S rDNA sequences. Amblyomma tonelliae has a 1‐year lifecycle characterized by a long pre‐moult period in larvae with no development of morphogenetic diapause. Larvae peak in abundance during late autumn and early winter; nymphs peak in abundance in spring, and adults do so from late spring to early summer. Amblyomma tonelliae shows a marked ecological preference for the driest areas of the Chaco ecoregion. In analyses of 16S rDNA sequences in genes from different populations of A. tonelliae, values for nucleotide diversity and the average number of nucleotide differences showed genetic diversity within this species to be low. No significant differences were found in comparisons among populations.
Electric signals and species recognition in the wave-type gymnotiform fish Apteronotus leptorhynchus

SUMMARY Gymnotiformes are South American weakly electric fish that produce weak electric organ discharges (EOD) for orientation, foraging and communication purposes. It has been shown that EOD properties vary widely across species and could thus be used as species recognition signals. We measured and quantified the electric signals of various species using a landmark-based approach. Using discriminant function analysis to verify whether these signals are species specific based on different signal parameters, we found that the EOD waveform is a more specific cue than EOD frequency, which shows large overlap across species. Using Apteronotus leptorhynchus as a focal species, we then performed a series of playback experiments using stimuli of different species (varying in frequency, waveform, or both). In an experiment with restrained fish, we found, in contrast to what we predicted, that the choice of stimulus waveform did not affect the production of communication signals. In an experiment with free-swimming fish, the animals spent more time near the playback electrodes and produced more communication signals when the stimuli were within their conspecific frequency range. Waveform again had no measurable effect. The production of communication signals correlated with the frequency difference between the stimulus and the fish's own EOD, but approach behavior did not.
Reação motivacional docente do Curso de Graduação em Ciências Contábeis sob a perspectiva da Teoria Atribucional

Few studies research about the causes of teacher motivation. Teachers should be considered as human beings and social actors, with problems and perspectives, people who struggle to achieve their goals and have a full career. They are motivated like any other professional, and by understanding these causes we can work on improving teaching and the effective process of teaching and learning. Thus, the aim of this study is to analyze the motivation of Accounting teach- ers from the perspective of attribution theory. The methodology used was descriptive and quantitative data collection approach. A survey was conducted among Accounting professors from three institutions in the State of Santa Catarina. Data analysis was performed using multidimensional scaling with SPSS software. Results pointed out the motives Accounting professors have to exercise their profession: love for the career; teaching and research; interpersonal relation- ships; career path; personal and professional satisfaction; working for a university; financial; learning and knowledge; vocational and professional status. The relationship between professor, students and their co-workers, effort and luck were the main causes of the motivation among these professionals.
Sexuality and intellectual disability : implications for sex education

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Recollections of J.B.S. Haldane, with special reference to Human Genetics in India

This paper is a brief account of the scientific work of J.B.S. Haldane (1892–1964), with special reference to early research in Human Genetics. Brief descriptions of Haldane's background, his important contributions to the foundations of human genetics, his move to India from Great Britain and the research carried out in Human Genetics in India under his direction are outlined. Population genetic research on Y-linkage in man, inbreeding, color blindness and other aspects are described.
Differential localization of NT‐3 and TrpM5 in glomeruli of the olfactory bulb of mice

Olfactory sensory neurons that express transient receptor potential channel M5 (TrpM5) or neurotrophin‐3 (NT‐3) project to defined clusters of glomeruli situated ventrally in the main olfactory bulb. Using genetically labeled mice, we investigated whether expression of NT‐3‐driven βgal and TrpM5‐driven GFP marked overlapping sets of glomeruli and whether expression of these markers was coordinated. Our results indicate that these markers largely characterize independent sets of olfactory sensory neuron axons and glomeruli. Further, in glomeruli in which both TrpM5‐GFP and NT‐3‐βgal labeled axons occur, they are expressed independently. The nature of staining for these two markers also differs within glomeruli. Within each labeled TrpM5‐positive glomerulus, the level of TrpM5‐GFP expression was similar throughout the glomerular neuropil. In contrast, NT‐3‐driven βgal expression levels are heterogeneous even within heavily labeled glomeruli. In addition, a population of very small TrpM5‐GFP positive glomeruli is apparent while no similar populations of NT‐3‐βgal glomeruli are evident. Taken together, these data suggest that TrpM5 and NT‐3 characterize two largely independent receptor populations both conveying odorant information to the ventral olfactory bulb. J. Comp. Neurol. 522:1929–1940, 2014. © 2013 Wiley Periodicals, Inc.
Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis

Primary biliary cirrhosis (PBC) is characterized by an immune‐mediated destruction of intrahepatic small bile ducts. Apoptosis, a unique pattern of cell death, has been suggested to be responsible for the biliary destruction in PBC. To address this issue, we attempted to detect the apoptosis of biliary epithelial cells by in situ nick‐end labeling and by the expression of apoptosis‐related proteins using immunohistochemistry in patients with various hepatobiliary diseases, including PBC. The data was noteworthy for several reasons. First, apoptosis was occasionally detected on biliary cells in all liver specimens; however, the positive rate was high in PBC and relatively low in other livers. Strong expression of CD95 was frequently observed in the epithelial cells of the injured bile ducts of PBC, which accompanied high intensity CD95 ligand‐expressing mononuclear cells. Perforin and granzyme B immunoreactivities were occasionally found on the bile ducts in control liver diseases as well as PBC, but granzyme B‐positive biliary cells were prominent in PBC. In contrast, Lewis Y expression, as detected using BM‐1 antibody, was consistently present in the injured bile ducts of PBC. These data suggest that apoptosis, via the perforin/granzyme B pathway, may be associated with the degrading fraction of cell cycle regulation in the small‐sized biliary tree under physiological and pathological liver conditions. Moreover, enhanced apoptosis, mediated by CD95/CD95 ligand interaction, may contribute to the bile duct injury and loss observed in PBC.
Emerging Adult Usage of Social Networks as Sites of Activism: A Critical Examination of the TOMS and TWLOHA Movements

_____________________________ Michaela D. E. Meyer (PhD, Ohio University, 2004) is Associate Professor at Christopher Newport University. Connie Workman Bray (B.A. Christopher Newport University, 2010) is currently employed as a media project leader for GEICO. A version of this essay was presented at the 2013 National Communication Association Annual Convention. Inquiries should be directed to mmeyer@cnu.edu. Emerging Adult Usage of Social Networks as Sites of Activism: A Critical Examination of the TOMS and TWLOHA Movements