Miracle-dz/UniFAR-FTUs huggingface dataset:
UvA-DARE ( Digital Academic Repository ) Kinome activity profiling and kinase modulation of pulmonary inflammation

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Receptors for cold-insoluble globulin (plasma fibronectin) on human monocytes

This investigation focused on the role played by cold-insoluble globulin (CIg, plasma fibronectin) in monocyte function. Surface-bound CIg mediated a concentration-dependent of human blood monocytes to gelatin-coated surfaces. CIg also mediated the binding of gelatin- coated particles such as latex beads or tanned erythrocytes to surface- bound human monocytes. However, CIg did not mediate particle ingestion. Subfractionated CIg that was highly enriched in monomeric forms (zone II CIg, mol wt 190,000-235,000) was less effective than were fractions enriched in dimeric forms (zone I CIg, mol wt 450,000) in promoting monocyte attachment. Binding of CIg to a gelatin or plastic surface occurred in the absence of divalent cations, but monocyte attachment to CIg-coated surfaces required divalent cations, Mg++ being much more effective than Ca++. Cation-dependent cell attachment was reversible in that bound cells could be released by treatment with EDTA. Serum- mediated binding of monocytes to gelatin-coated plastic dishes was a result of its content of CIg because the binding activity was abolished by removal of CIg from serum, and could be restored by readdition of purified CIg. Treatment of monocytes with trypsin abolished subsequent cell attachment to CIg-gelatin surfaces or particles. Expression of certain other known monocyte membrane receptors (Fc and C3b) was markedly enhanced as a result of CIg-monocyte interaction. These several observations indicate that monocytes bear membrane receptors (termed receptor cold-insoluble globulin) for surface-bound CIg.
Local treatment of the inner ear: A study of three different polymers aimed for middle ear administration

Abstract Conclusion: A formulation based on sodium hyaluronate (NaHYA) was the most promising candidate vehicle for intra-tympanic drug administration regarding conductive hearing loss, inflammatory reactions, and elimination. Objectives: Recent advances in inner ear research support the idea of using the middle ear cavity for drug administration to target the inner ear. This paper presents rheological and safety assessments of three candidate polymer formulations for intra-tympanic drug administration. Method: The formulations were based on sodium carboxymethyl cellulose (NaCMC), sodium hyaluronate (NaHYA), and poloxamer 407 (POL). Rheological studies were performed with a controlled rate instrument of the couette type. Safety studies were performed in guinea pigs subjected to an intra-tympanic injection of the formulations. Hearing function was explored with ABR before and 1, 2, and 3 weeks after the injection. Elimination of the formulations marked with coal was explored with an endoscopic digital camera 1, 2, and 3 weeks after injection. Middle and inner ear morphology was examined with light microscopy 6 days after injection. Results: The results speak in favor of NaHYA, since it did not cause prolonged hearing threshold elevations. The results of the elimination and morphological investigations support the conclusion of NaHYA being the most promising candidate for intra-tympanic administration.
Lingual-occlusal surface position predicts retroglossal obstruction in patients with obstructive sleep apnea hypopnea syndrome

Abstract Conclusion: Lingual-occlusal surface position was significantly related to retroglossal obstruction, and lingual-occlusal surface position may be an available reference in clinical practice for the preliminary assessment of retroglossal obstruction. Objective: To investigate the relationship between lingual-occlusal surface position and retroglossal obstruction in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Materials and methods: A total of 140 patients with OSAHS diagnosed by polysomnography (PSG) were enrolled. Lingual-occlusal surface position was evaluated and classified into three types. Airway computed tomograpy (CT) was performed to measure the retroglossal cross-sectional area and inner diameter. The PSG was repeated after the nasopharyngeal tube insertion (NPT-PSG). The NPT-PSG results, CT-measured data and incidence of retroglossal obstruction were compared among the different lingual-occlusal surface positions groups. Results: The demographics of OSAHS patients with different lingual-occlusal surface positions was similar. As lingual-occlusal surface position type varied from type I to type III, retroglossal cross-sectional area and inner diameter decreased, retroglossal airway obstruction rate increased, apnea hypopnea index (AHI) measured by NPT-PSG increased, and lowest oxygen saturation (LaSO2) decreased.
Multimodal Neuromonitoring in Neurocritical Care

&NA; Neuromonitoring is important for patients with acute brain injury. The bedside neurologic examination is standard for neurologic monitoring; however, a clinical examination may not reliably detect subtle changes in intracranial physiology. Changes found during neurologic examinations are often late signs. The assessment of multiple physiological variables in real time can provide new clinical insights into treatment decisions. No single monitoring modality is ideal for all patients. Simultaneous assessment of cerebral hemodynamics, oxygenation, and metabolism, such as in multimodal monitoring, allows an innovative approach to individualized patient care.
Dynamic output feedback stabilisation with H∞ performance for a class of LTIPD systems using PPDQ functions

This paper describes a new sufficient condition for the Dynamic Output Feedback (DOF) stabilisation of linear time invariant parameter-dependent systems in the presence of norm-bounded non-linear uncertainties. The required sufficient conditions with high precision are expressed as Linear Matrix Inequalities (LMIs) using the idea of Polynomial Parameter-Dependent Quadratic (PPDQ) functions. It is shown that the parameter-dependent DOF control ensures robust asymptotically stability and robust disturbance attenuation, simultaneously, based on the Hamiltonian-Jacobi-Isaac method. The applicability of the proposed method is illustrated with a simple example.
Exposure to non-core foods and beverages in the first year of life: Results from a cohort study

Aim: To report the proportion of Australian infants who were introduced to non-core foods and beverages and to identify factors that are associated with the introduction of non-core foods and beverages to infants in the first year of life. Methods: Participants were 587 women recruited from two maternity hospitals in Perth and followed up by telephone interview at 4, 10, 16, 22, 32, 40 and 52 weeks post-partum to collect information on infant feeding practices. Factors associated with introduction of non-core foods and beverages by 52 weeks post-partum were identified using multivariate logistic regression. Results: The three non-core foods most commonly introduced to infants by 52 weeks post-partum were biscuits and cakes (91.6%, n = 415), hot chips/French fries (78.6%, n = 356) and ice-cream (68.2%, n = 309). Independent predictors of introduction of non-core foods and beverages by 52 weeks post-partum were age at which solids were first introduced and the presence of older siblings. Conclusion: Identifying factors associated with the introduction of non-core foods and beverages to infants is important to help health professionals better target early feeding interventions. Consistent recommendations are required to ensure clear understanding of what foods are suitable and not suitable for infants.
Autofluorescence spectroscopy in the differentiation of laryngeal epithelial lesions – preliminary results

Abstract Conclusions Autofluorescence spectroscopy may be a supporting tool for differential diagnosis of changes in laryngeal epithelium. Objectives Early detection and differential diagnosis of proliferative changes in the larynx are still a challenge for laryngologists. The aim of the study was to evaluate the autofluorescence spectroscopy technique to in vitro differential diagnosis of pathological changes in the epithelium of the larynx. Methods Forty-two patients aged 34–79 years were included in the study. The fifty-two tissue specimens, including 10 samples of cancerous lesion, 10 adjacent normal tissue, 10 chronic inflammation, eight cyst, three leukoplakia, four polyp, and seven Reinke’s edema, were obtained during laryngological procedures. All tissue samples were independently diagnosed histopathologically. The autofluorescence emission spectra at two excitation wavelengths, 290 nm and 370 nm, were measured for every sample studied. Results The autofluorescence signals of cancerous tissue samples at both excitations exhibited identical emission band shapes of much lower intensities at their maxima as compared to the adjacent healthy tissue samples studied. The autofluorescence spectra intensities of cancerous and normal tissues varied inter-individually. Evident differences in autofluorescence intensities and its band shapes of different pathological laryngeal changes at the 290 nm excitations were demonstrated.
O potencial diagnóstico dos indicadores da obesidade centralizada

OBJETIVO: Tem sido sugerido que os indicadores da obesidade centralizada, representados pela relacao entre as medidas das circunferencias da cintura e do quadril e pela medida da circunferencia da cintura, expressam disturbios metabolicos diferentes. Assim, realizou-se estudo para verificar o potencial diagnostico da relacao circunferencia cintura/circunferencia do quadril com fatores sociais, comportamentais e biologicos, determinantes da obesidade centralizada. METODOS: Em uma amostra da populacao do Municipio de Sao Paulo, SP, composta por 1.042 pessoas, foram utilizados dois modelos de analise hierarquica de regressao multipla para se avaliar as relacoes entre os indicadores e os fatores determinantes da obesidade centralizada. Foram realizados tres inqueritos (clinico, bioquimico e laboratorial e comportamental), utilizando questionario padronizado. Para avaliacao, foram utilizados os instrumentos: pressao arterial, medidas antropometricas, medida de cintura e medida do quadril. RESULTADOS: A medida de circunferencia da cintura e do quadril (RCQ) mostrou associacao significativa com a baixa estatura e foi fortemente relacionada ao nivel socioeconomico, nao ocorrendo o mesmo com a CC. A RCQ e a medida de circunferencia da cintura (CC) foram fortemente associadas a idade, sexo e sedentarismo. As mulheres tem maior risco de apresentaram obesidade centralizada: OR=5,04 e 7,27, para a RCQ e CC, respectivamente. No que se refere aos disturbios metabolicos, a RCQ associou-se significativamente com as alteracoes indicativas da sindrome metabolica: hipertensao e baixos niveis de HDL-colesterol. A CC associou-se significativamente com a hipertensao isolada. Ambos os indicadores associaram-se intensamente com a presenca concomitante de duas ou mais alteracoes ligadas a sindrome metabolica. A CC associou-se a hipercolesterolemia, o que nao ocorreu com a RCQ. CONCLUSOES: A RCQ relacionou-se melhor com os fatores socioeconomicos, risco de desnutricao pregressa e com as alteracoes indicativas da sindrome metabolica do que a CC, mais associada aos fatores de risco para doencas cardiovasculares ateroscleroticas.
Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings

Abstract Conclusion: In Kikuchi-Fujimoto disease (KFD), a low ratio of blastic cells (<70%) in lymph node specimens and absence of atypical lymphocytes in peripheral blood are predictive of a protracted clinical course. Objectives: Since KFD is a self-limiting disorder that does not require any specific management, prognostic factors have received little attention. The present study identified clinical and pathological factors that may affect the period from onset to cure of KFD. Methods: This retrospective study investigated 43 KFD patients who underwent lymph node biopsy diagnosed by immunohistochemical staining at Okayama University Hospital and Okayama Medical Center from January 2001 to December 2013. Results: Mean total period from onset to cure was 6 months (median =9.4 months; range =1–37 months). Low ratios of blastic cell proliferation area (<70%) in lymph node specimens (p = 0.011) and absence of atypical lymphocytes in peripheral blood (p = 0.026) were associated with a relatively long duration of KFD.
The role of standardized protocols in unplanned extubations in a medical intensive care unit.

BACKGROUND Many patients admitted to medical intensive care units require mechanical ventilation to assist with respiratory management. Unplanned extubations of these patients are associated with poor outcomes for patients and organizations. No previous research has investigated the role of standardized protocols in unplanned extubations when examined in conjunction with traditional risk factors. OBJECTIVE To identify risk factors associated with unplanned extubation among patients receiving mechanical ventilation and determine degree of compliance with pain, sedation, and weaning protocols. METHODS A prospective cohort study design was used. Data on all patients admitted to the medical intensive care unit who required mechanical ventilation were gathered daily. Additional data were gathered on those patients who experienced unplanned extubation. Descriptive, correlational, and regression analyses were performed. RESULTS Weaning protocols were a significant predictor of unplanned extubation: patients who had weaning protocols ordered and followed were least likely to experience unplanned extubation. Only 10% of the 190 patients in the study required reintubation, resulting in a significantly shorter ventilation time and unit length of stay among the unplanned extubation group. CONCLUSIONS Weaning protocols were associated with decreased incidence of unplanned extubation. Use of standardized protocols was feasible, as compliance among health care providers was high when protocols were medically prescribed. The reintubation rate in this study was low and associated with a significantly shorter ventilatory period and unit length of stay in the unplanned extubation group.
Single injury incidents among pedestrians and biscyclists in northern Sweden : safety and preventive issues

Every year, in Sweden, more than 4,000 people require inpatient care for single injury incidents obtained while walking or bicycling in a traffic environment. The aim of this study is to describe causes of single injury incidents among pedestrians and bicyclists and to identify preventive strategies. The study is based on data from the injury registration database at the University Hospital in Umea and from a complementary questionnaire containing questions regarding the causes of injury and preventive strategies. The questionnaire was distributed to all pedestrians and bicyclists injured in single incidents in a city in northern Sweden and who had visited the hospital in 2009 because of those injuries. The data set is comprised of medical data for all 367 patients (244 pedestrian and 123 bicyclists) who responded to the questionnaire. The results from this study show that the pedestrians and bicyclists differ in their reports regarding causes of their injuries and the differences seem to be related to injury severity. The pedestrians mainly referred to environmental factors as causes to their injuries, while the bicyclists referred to environmental factors, product factors, and human factors as causes of the injury incident. Regarding preventive strategies, the views of the pedestrians and the bicyclists is in line with their views of causes to their injuries. The results are useful for developing preventive strategies for differing groups of road users.
Does School Bullying Affect Adult Health? Population Survey of Health-Related Quality of Life and Past Victimization

Objective: The purpose of the present study was to determine the proportion of adult South Australians who report having experienced school bullying and to examine the relationship between past victimization and adult health-related quality of life. Method: A representative sample (n=2833) of metropolitan and country South Australian adults were asked in a face-to-face interview whether they had experienced bullying when they were at school. Health-related quality of life was measured using the Medical Outcomes Study Short Form 36-item health survey questions (SF-36). Regression analyses (linear and logistic) were performed, taking into account survey weights. Results: Nearly one-fifth of adults reported having experienced bullying when they were at school. Older persons and those born overseas were less likely to report having been bullied. Those reporting that they had been bullied experienced significantly poorer mental and physical health compared to those who had not been bullied. Conclusions: Adults commonly reported experiencing bullying while at school and these reports were associated with lower health-related quality of life in adulthood. School bullying needs further investigation as a preventable cause of mental health problems across the lifespan.
Evolution of Human Brain Functions: The Functional Structure of Human Consciousness

The functional structure of self-aware consciousness in human beings is described based on the evolution of human brain functions. Prior work on heritable temperament and character traits is extended to account for the quantum-like and holographic properties (i.e. parts elicit wholes) of self-aware consciousness. Cladistic analysis is used to identify the succession of ancestors leading to human beings. The functional capacities that emerge along this lineage of ancestors are described. The ecological context in which each cladogenesis occurred is described to illustrate the shifting balance of evolution as a complex adaptive system. Comparative neuroanatomy is reviewed to identify the brain structures and networks that emerged coincident with the emergent brain functions. Individual differences in human temperament traits were well developed in the common ancestor shared by reptiles and humans. Neocortical development in mammals proceeded in five major transitions: from early reptiles to early mammals, early primates, simians, early Homo, and modern Homo sapiens. These transitions provide the foundation for human self-awareness related to sexuality, materiality, emotionality, intellectuality, and spirituality, respectively. The functional structure of human self-aware consciousness is concerned with the regulation of five planes of being: sexuality, materiality, emotionality, intellectuality, and spirituality. Each plane elaborates neocortical functions organized around one of the five special senses. The interactions among these five planes gives rise to a 5 × 5 matrix of subplanes, which are functions that coarsely describe the focus of neocortical regulation. Each of these 25 neocortical functions regulates each of five basic motives or drives that can be measured as temperaments or basic emotions related to fear, anger, disgust, surprise, and happiness/sadness. The resulting 5 × 5 × 5 matrix of human characteristics provides a general and testable model of the functional structure of human consciousness that includes personality, physicality, emotionality, cognition, and spirituality in a unified developmental framework.
Transcutaneous Feeding: The Effect of Massage with Coconut Oil on Weight Gain in Preterm Newborns

Background: Transcutaneous feeding has been suggested for infants with very low birth-weight. In this study, we evaluated the effect of massage with coconut oil on weight gain in preterm newborns. Patients and Methods: This quasi-experimental study was conducted from August 2007 to March 2008 in Mashhad Medical University in Mashhad, IR Iran. Seventy-three newborns were randomly assigned to 3 groups: A (massage with coconut oil), B (massage only), and C (control group). The weights of the newborns in all 3 groups were measured daily by a nurse who was blinded to the study. Data were plotted and analyzed using the SPSS 14 graphical software. Analysis of variance (ANOVA), Kruskal-Wallis test, and paired t test analyses were performed to evaluate the effect of massage with coconut oil on weight gain. Results: There was a significant difference between the weight gain in the 3 groups after the intervention. The results of Tukey test indicated that there was a significant difference between the results in groups A and B and groups A and C, but there was no significant difference between those in groups B and C. Conclusions: Massage with coconut oil has a positive effect on weight gain in preterm newborns.
New Di- and Triorganotin(IV) Tyrosylalaninates as Models for Metal—Protein Interactions: Synthesis, Structural Characterization, and Potentiometric Studies of Tyrosylalanine, Glycyltyrosine, and Glycylisoleucine with Di- and Trimethyltin(IV) Moieties in Aqueous Medium

Di- and triorganotin(IV) derivatives of tyrosylalanine (H2Tyr-Ala) with general formula R2Sn(Tyr-Ala) (where R = Me, n-Bu, n-Oct, and Ph) and R3Sn(HTyr-Ala) (where R = Me and Ph) have been synthesized and structurally characterized in the solid state as well as in solution on the basis of various spectroscopic techniques, namely. FT-IR, multinuclear (1H, 13C and 119Sn) NMR and 119Sn Mossbauer. These investigations suggest that tyrosylalanine in R2Sn(Tyr-Ala) acts as dianionic tridentate ligand coordinating through carboxylate oxygen [–C(O)O−], amino (–NH2), and (CO)N−peptide nitrogen, while in the case of R3Sn(HTyr-Ala), the ligand acts as monoanionic bidentate coordinating through –C(O)O− and –NH2, and the polyhedron around tin in R2Sn(Tyr-Ala) and R3Sn(HTyr-Ala) is a distorted trigonal-bipyramidal. Equilibrium (pH-metric) studies of the interaction of Me2Sn(IV)2
Assessment of renal function of Nigerian children infected with Plasmodium falciparum

The levels of kidney function parameters were estimated in children infected withPlasmodium falciparum malaria to determine its association with renal impairment. Apparently healthy children with no malaria infection were included as the control subjects. It was observed that the levels of serum urea, serum creatinine, and protein in urine were significantly higher in infected children when compared with the control values. The relationship between parasitaemia density and serum urea were negatively correlated (r = -0.44), but serum creatinine (r = 0.61) and protein in urine (r = 0.47) were positively correlated. There was no significant change in serum electrolytes levels in the infected subjects compared to the control. Children within 1 - 5 years of age had higher parasitaemia density (8677.48 ± 3241.82 /µL) than those between 6 - 12 years of age (4881.72 ± 872.36 /µL). These children (1 - 5 years) had higher levels of serum urea (6.44 ± 0.36 mmol/L), serum creatinine (126.88 ± 12.24 µmol/L) and protein in urine (28.07 ± 2.66 mg/dl) when compared with children between 6 - 12 years (serum urea = 5.27 ± 0.91 mmol/L, serum creatinine = 123.76 ± 4.32 µmol/L and protein in urine = 19.64 ± 3.91 mg/dl). The result suggested that renal impairment was associated with malaria infection. Key words: Children, Plasmodium falciparum, renal function.