Miracle-dz/UniFAR-FTUs huggingface dataset:
Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.

OBJECTIVE To investigate the role of the novel cytokine high mobility group box chromosomal protein 1 (HMGB-1) in the pathogenesis of cutaneous lupus erythematosus (CLE). METHODS Punch biopsy specimens of lesional and unaffected skin from 10 patients with CLE and 3 healthy control subjects were investigated. Immunohistochemical staining for HMGB-1, tumor necrosis factor alpha (TNFalpha), and interleukin-1beta (IL-1beta) was performed on consecutive sections. Analysis of single-nucleotide polymorphisms of -308 TNF was performed on DNA extracted from peripheral blood mononuclear cells. RESULTS An altered expression of HMGB-1 was observed both in the epidermis and in the dermal infiltrates of lesional skin. Expression of HMGB-1 in the epidermis and dermis was increased (P < 0.01 and P < 0.001, respectively, versus unaffected skin), and translocation to the cytoplasm as well as the extracellular presence of secreted HMGB-1 were found. Increased levels of TNFalpha and IL-1beta were also observed in the dermal infiltrates of lesional skin (P < 0.01 and P < 0.05, respectively, versus unaffected skin). The carrier frequency of the -308A TNF polymorphism was 80% in patients with subacute CLE, but this was not related to higher expression of TNFalpha in biopsy specimens from the CLE group. CONCLUSION The high amount of extracellular HMGB-1 observed in skin lesions indicates that HMGB-1 is involved in the inflammatory process of CLE. TNFalpha and IL-1beta may form a proinflammatory loop with HMGB-1, since they can induce the release of each other. The extracellular HMGB-1 observed by immunostaining of the epidermis indicates that keratinocytes may be an as yet unrecognized source of secreted HMGB-1, underscoring the role of the target organ in the rheumatoid autoimmune inflammatory process.
Mechanical characterization of yeast cells: effects of growth conditions

Industrial biotechnology uses microbiological cells to produce a wide range of products. While the organisms in question are well understood regarding their genetic and molecular properties, less is known about their mechanical properties. Previous work has established a testing procedure for single Saccharomyces cerevisiae cells using a Nanoindenter equipped with a Flat Punch probe, allowing the compression between two parallel surfaces. The resulting force‐displacement curves clearly showed the bursting of the cells and served to determine characteristic values such as the bursting force, bursting energy and relative deformation. This study examined the mechanical characteristics of yeast cells under the influence of varying cultivation parameters, namely the pH value, temperature, aeration rate, stirrer speed and culture medium composition. It was observed that only temperature and medium composition showed significant effect on the mechanical properties of the cells. Higher temperatures during cultivation caused lower bursting forces and energies. Further analysis of the data showed that the mechanical characteristics of the cells were only influenced by parameters which also had an influence on the growth rate. In conclusion, higher growth rates result in a lower mechanical strength of the yeast cells.
The changing wealth of nations 2018 : building a sustainable future

Countries regularly track gross domestic product (GDP) as an indicator of their economic progress, but not wealth—the assets such as infrastructure, forests, minerals, and human capital that produce GDP. In contrast, corporations routinely report on both their income and assets to assess their economic health and prospects for the future. Wealth accounts allow countries to take stock of their assets to monitor the sustainability of development, an urgent concern today for all countries. This book begins with a review of global and regional trends in wealth over the past two decades and provides examples of how wealth accounts can be used for the analysis of development patterns. Several chapters discuss the new work on human capital and its application in development policy. The book then tackles elements of natural capital that are not yet fully incorporated in the wealth accounts like air pollution, marine fisheries, and ecosystems. This book targets policy makers but will engage anyone committed to building a sustainable future for the planet.
Vascular biomarkers in migraine

Aim Migraine has been associated with stroke as well as with several non-atherosclerotic vascular conditions leading to discussions about the potential role of endothelium in the etiopathogenesis of migraine and migraine-associated stroke. We present a systematic review of the literature on vascular biomarkers in migraine, including those suggesting endothelial activation and damage. Methods We conducted a systematic literature search from 1990 to 2013 using multiple research databases with the keywords “migraine,” “headache,” “vascular,” and “biomarkers. ” We used selected inclusion and exclusion criteria to create a final pool of studies for this review. Results The literature search identified a total of 639 citations of which 129 were included in our review. The final pool of clinical- and population-based studies assessed the level of various biomarkers (e.g. inflammatory, prothrombotic, endothelial activation, endothelial repair) in migraineurs of varying ages, gender, and demographic characteristics. Although for each biomarker there is at least one study suggesting an association with migraine, in many cases the quality of evidence is poor and there are conflicting studies showing no relationship. The results were, therefore, in each case inconclusive. Conclusion This systematic review indicated that in migraine populations there are a number of positive vascular biomarker studies, including some involving novel biomarkers such as endothelial microparticles and endothelial precursor cells. These lend insight into possible pathophysiological mechanisms by which migraine may be associated with stroke. More high-quality studies are needed to establish whether a true association between promising vascular biomarkers and migraine exists.
The role of vitamin D supplementation on erectile function D vitamininin erektil fonksiyon üzerine etkisi

In the last few years growing evidence highlighted vitamin D (VD) deficiency is one of the several dynamics that associates with increased atherosclerotic cardiovascular (ASCV) diseases. ASCV diseases and erectile dysfunction (ED) share common risk factors such as diabetes mellitus, hypertension, smoking, hyperlipidemia, and a sedentary lifestyle. The aim of this review was to summarize current progress in VD research by focusing effect of low VD level on different body systems and erectile function. Here we examine research linking VD deficiency and ED and discuss how VD influences ED and its classic risk factors that also associate to increased ED risk. We also summarize research indicating that VD associates with reduced risk of several nonvascular contributing factors for ED. Available literature demonstrates relatively high rates of low VD serum levels in ED patients. Based on the preclinical and clinical data available in the literature, to date, we infer that VD play a critical role in maintaining erectile function in humans. Nevertheless, this should also be tested through randomized controlled studies on the effect of VD supplementation with larger population.
Sex differences in dynamic closed kinetic chain upper quarter function in collegiate swimmers.

CONTEXT Upper quarter injuries have a higher incidence in female swimmers; however, to date, there are few ways to assess the basic functional ability of this region. The upper quarter Y balance test (YBT-UQ) may assist in this process because it was developed to provide a fundamental assessment of dynamic upper quarter ability at the limit of stability. OBJECTIVE To examine how sex affects performance on the YBT-UQ in swimmers. DESIGN Cohort study. PATIENTS OR OTHER PARTICIPANTS Forty-three male and 54 female National Collegiate Athletic Association Division I college swimmers were recruited preseason. MAIN OUTCOME MEASURE(S) We measured YBT-UQ performance for the left and right limbs in the medial, inferolateral, and superolateral directions. The maximum score for each direction was normalized to upper extremity length. The average of the greatest normalized reach scores in each reach direction was used to develop a composite score (average distance in 3 directions/limb length [LL] × 100). To examine reach symmetry between sexes, the difference in centimeters between the left and right sides was calculated for each reach direction prior to normalization. Statistical analysis was conducted using an independent-samples t test (P < .05). RESULTS Average scores in the medial (women: 92.5 ± 7.4%LL, men: 100.0 ± 8.7%LL; P < .01) and inferolateral (women: 85.6 ± 10.3%LL, men: 89.8 ± 10.8%LL; P = .05) directions and composite score (women: 83.4 ± 8.3%LL, men: 88.3 ± 8.9%LL; P < .01) were higher in men than in women. No differences were observed for reach symmetry in any direction. CONCLUSIONS Performance on several YBT-UQ indices was worse for female than male collegiate swimmers. These results may have implications for the use of preseason and return-to-sport testing in swimmers as a measurement of upper quarter function and symmetry.
Identification of a cellular repressor of transcription of the adenoviral late IVa(2) gene that is unaltered in activity in infected cells.

The gene encoding the adenovirus type 2 IVa(2) protein, a sequence-specific activator of transcription from the viral major late promoter, is itself transcribed only during the late phase of infection. We previously identified a cellular protein (IVa(2)-RF) that binds specifically to an intragenic sequence of the IVa(2) transcription unit. We now report that precise substitutions within the IVa(2)-RF-binding site that decreased binding affinity increased the efficiency of IVa(2) transcription in in vitro reactions containing IVa(2)-RF. Consistent with the conclusion that this cellular protein represses IVa(2) transcription, mutations that led to more efficient transcription in the presence of IVa(2)-RF were without effect in reactions lacking this cellular protein. No change in the concentration or activity of IVa(2)-RF could be detected in adenovirus-infected cells during the period in which the IVa(2) gene is transcribed. We therefore propose that restriction of IVa(2) transcription to the late phase is the result of titration of this cellular repressor as the number of copies of the IVa(2) promoter increases upon replication of the viral genome.
Rare Ectopic Pregnancies – A Literature Review for the Period 2007 – 2019 on Locations Outside the Uterus and Fallopian Tubes

The majority of ectopic pregnancies (EP) are tubal pregnancies, but other implantation sites outside the uterus and tubes are also found. These rare EP locations present a particular diagnostic and therapeutic challenge. We present an overview of potential very rare locations of ectopic pregnancies, their symptoms, diagnosis and treatment, based on a systematic analysis of case reports. A literature review of the databases PubMed, Livivo and Google Scholar for the period 2007 to 2019 was carried out. A total of 113 publications were included in our review. These studies describe EP implantations in the posterior cul-de-sac, on the uterine serosa and uterine ligaments, in the vicinity of almost all intraperitoneal organs, on the abdominal wall as well as in retroperitoneal sites. The most common presenting symptom was abdominal pain occurring in different locations. The diagnostic procedures included various imaging procedures and/or explorative surgery at different advanced stages of pregnancy. The most common and preferred option was laparotomy for surgical treatment. The placenta was successfully resected in the majority of cases. A rare EP location should be considered when making a differential diagnosis in patients of child-bearing age with abdominal pain.
The Appositional Articular Morphology of the Talo‐crural Joint: The Influence of Substrate Use on Joint Shape

The appositional articular morphology of the talo‐crural joint is the third component of the joint complex. It is a site of internal integration of this highly stable functional evolutionary unit. Prior studies of the other two components, tibia and talus, demonstrated that substrate preference influenced their articular shape. This effect was unrelated to physical attributes (size and mass) and phylogeny (superfamily). The effect of this behavioral factor, substrate preference, on shape and integration of the appositional articular morphology was investigated. Two hundred forty‐five matched distal tibial and proximal talar landmarked surfaces from 12 diverse Catarrhine taxa were studied. Shape effects due to the same factors previously studied were examined in the tibial and talar subsets and were highly significant (P < 0.0001). These were assessed using Multivariate Regression and Relative Warps analysis, and Permutation tests, with results consistent with prior unmatched cohorts. Substrate preference influenced shape and was unrelated to the other factors across taxa. Singular Warp analysis of the cross‐covariance matrix revealed sorting of taxa by substrate use, unrelated to physical attributes and phylogeny. Finally, the sorting demonstrated a signal of convergent evolution among distantly related taxa and divergent evolution among closely related taxa reflecting substrate use. Results were consistent with a behavioral influence, substrate use, affecting articular shape and integration in this highly stable functional evolutionary unit, and signals with evolutionary implications. Anat Rec, 297:618–629, 2014. © 2014 Wiley Periodicals, Inc.
Components of class II malocclusion in children 8-10 years of age.

Abstract A cross-sectional lateral cephalometric evaluation of the distribution of specific relationships in subjects with a Class II malocclusion. Broad variation was found, with retrusion and excessive height of the lower face among the most common findings. Presented at the Biennial meeting of the Edward H. Angle Society of Orthodontists, Hilton Head, South Carolina, October, 1979.
Implications of decision making process on agricultural employees’ turnover in institute of agricultural research and training Ibadan, Oyo state, Nigeria

This study was designed to determine the implications of decision making process on employees’ turnover in the Institute of Agricultural Research and Training Ibadan, Oyo State, Nigeria. Simple random sampling technique was used to select 73 respondents from the study area with the use of a well-structured questionnaire. Data were collected primarily and were analyzed using descriptive and inferential statistical tools. Results showed the mean ages of employees to be 31 years, majority (56.9%) of them were male (48.6%) had B.Sc. as their educational qualification and 66.7% were married. The mean years of experience was 5 years and 59.7% were Christians. More so, decision was easier based on employee’s opinions (𝑥 = 3.65), decisions are made by a set of people in the organization (𝑥 = 3.28) and important suggestions are neglected by supervisors (𝑥 = 2.61). Hierarchical decision making process (59.7%) was the major type identified. Furthermore, work life imbalance (𝑥 = 3.32), cost of training and recruitment (𝑥 = 3.18) and lack of growth opportunity (𝑥 = 3.10) are causes of employee turnover. Conflict (𝑥 = 2.38), unfavourable decision making process (𝑥 = 2.13) and job insecurity (𝑥 = 2.22) were major challenges affecting decision making process. The results also shows that level of decision making process with coefficient value of (0.476), age (−0.079), sex (−0.014), rank (−0.228), income (0.145) and challenges (−0.021) were variable influencing employee’s turnover. This study concluded that employees’ participation in decision making process will reduce employees’ turnover. Growth opportunity in terms of training is highly recommended. Key words : implication, decision making, process, agricultural employees, turnover and research institute
: Arguments , Facts and Sources

Social media collect and spread on the Web personal opinions, facts, fake news and all kind of information users may be interested in. Applying argument mining methods to such heterogeneous data sources is a challenging open research issue, in particular considering the peculiarities of the language used to write textual messages on social media. In addition, new issues emerge when dealing with arguments posted on such platforms, such as the need to make a distinction between personal opinions and actual facts, and to detect the source disseminating information about such facts to allow for provenance verification. In this paper, we apply supervised classification to identify arguments on Twitter, and we present two new tasks for argument mining, namely facts recognition and source identification. We study the feasibility of the approaches proposed to address these tasks on a set of tweets related to the Grexit and Brexit news topics.
The state-of-the- art of the statistical theory of antenna arrays

In the paper the author set forth foundations of the theory of antenna arrays with randomness in excitation and position of radiators. Main attention is paid to problems of the analysis of statistical characteristics of similar arrays in the far zone. The theoretical generalization to the Fresnel zone both for equidistant and non-equidistant arrays is given along with problems in the analysis (direct problems), the inverse problems - the problems of the statistical synthesis of antenna arrays. The most important literature characterizing the state-of-the-art in the statistical theory of antenna arrays is indicated.
Going Public Decision of Initial Public Offerings (IPO) in Hot Issue Market: Case of Pakistan Stock Exchange

The aim of the study is to examine the significant factors that influence the going public decision of IPOs in Pakistan during hot issue market. The study fisrtly identified the hot and cold issue periods in Pakistan by using volume based method. The study secondly examined the imapct of firm level, industry level and country level factors on going public decision in Pakistan. The study thirdly explored whether and going public theories are pertient to Pakistan. The analysis of all non-financial firms listed on the Pakistan Stock Exchange (PSX) was conducted from the period of 2000 to 2015. This study utilized the volume and initial returns-based method to identify the hot and cold issue markets. The logit regression model is used to examine the significant determinants of going public decision during hot issue market. The result indicated that the largest number of IPOs per year were issued around the year 2003-2005, 2007 and 2014-2015 trailed by the inflated underpricing, known as hot issue market. Nevertheless, the periods between 2000-2002, 2006, 2008-2013 are declared as cold issue market, where less number of IPOs and underprcing is observed. The result further shows that the industry condition along with firm-level, and country level factors played an important role in determining firmâ€™s going public decision during hot issue market. The findings of this study strongly supported the conventional wisdom of signaling, changing risk composition, information spill-over, and capital demand hypothesis. The findings of the study is consistent with previous literature (Alim et al., 2017; Shehzad Khan, 2017; Khan et al., 2016; Khan et al., 2014; Benveniste et al., 2002).
Prognosis in Hodgkin's disease with special reference to histologic type. Results of treatment predominantly by cytostatics.

Prognosis in Hodgktn's Disease with Special Reference to Histologic Type: Results of Treatment Predominantly by Cytostatics A. P. Andersen, H. Brincker & F. Lass To cite this article: A. P. Andersen, H. Brincker & F. Lass (1970) Prognosis in Hodgktn's Disease with Special Reference to Histologic Type: Results of Treatment Predominantly by Cytostatics, Acta Radiologica: Therapy, Physics, Biology, 9:2, 81-101, DOI: 10.3109/02841867009129092 To link to this article: https://doi.org/10.3109/02841867009129092
Development of phyto-technology for decreasing heavy metal in food Mechanism and source of arsenic contamination in groundwater in Bangladesh

Naturally occurring contamination of arsenic is of great concern in many Southeast Asian countries especially in Bangladesh. Because of the lack of understanding for the mechanism of As contamination, we have developed two studies through field surveys and laboratory experiments. First topic is focused on the underlying mechanisms controlling large spatial variation of As-contaminated groundwater based on the adsorption reaction. Because adsorption is kinetically first reaction, we hypothesized that groundwater As level for each household well water should controlled by adsorption equilibrium between sediment and water. To verify the hypothesis, we firstly verified adsorption equilibrium using the batch adsorption experiment for the sediment collected from As contaminated region in Bangladesh coupled with solid phase As speciation using X-ray absorption fine structure. The results indicate that dissolved As level is consistent with adsorption equilibrium. We further introduce a new insight to analyze contamination mechanism based on the adsorption equilibrium model. The second topic is the novel approach to identify the ultimate source of As using Sb stable isotope. Although there are enormous numbers of research about arsenic contamination in Bangladesh, the primordial source of arsenic is still unknown. Because arsenic is a monoisotopic element, we cannot discuss this issue using isotope geochemistry of arsenic, which can be a part of the reason why the source of arsenic contamination is unclear. Because of the similar geochemical behavior of As and Sb, we are trying to establish the antimony isotope analysis and verify its applicability to the source analysis of arsenic. Here, two topics: (i) determination method of antimony isotope in natural sample by multicollecter-type ICP-MS, and (ii) verification for the similarity of antimony and arsenic behavior in river water-sediment systems based on a model study around the Ichinokawa antimony mine, is introduced.