Miracle-dz/UniFAR-FTUs huggingface dataset:
Cortical Areas Associated With Mismatch Negativity: A Connectivity Study Using Propofol Anesthesia

Auditory mismatch negativity (MMN) is an event-related potential (ERP) waveform induced by rare deviant stimuli that occur in a stream of regular auditory stimuli. The generators of MMN are believed to include several different cortical regions like the bilateral temporal and the right inferior frontal gyrus (IFG). However, exact cortical regions associated with MMN remain controversial. In this study, we compared the number of long-distance connections induced by the standard and deviant stimuli during awake state and propofol anesthesia state to identify the cortical areas associated with the generation of MMN. In awake state, we find that deviant stimuli synchronize more information between the right frontal and temporal than standard stimuli. Moreover, we find that the deviant stimuli in awake state activate the bilateral frontal, central areas, the left temporal and parietal areas as compared to the anesthesia state, whereas the standard stimuli do not. These results suggest that, in addition to the bilateral temporal and the right IFG, the bilateral frontal and centro-parietal regions also contribute to the generation of MMN.
Event-Triggered Adaptive Tracking Control for Multiagent Systems With Unknown Disturbances

This paper considers the event-triggered tracking control problem of nonlinear multiagent systems with unknown disturbances. The event-triggering mechanism is considered in the controller update, which decreases the amount of communication and reduces the frequency of the controller update in practice. By designing a disturbance observer, the unknown external disturbances are estimated. Moreover, a part of adaptive parameters are only dependent on the number of followers, which weakens the computational burden. It is shown that all the signals are bounded, and the consensus tracking errors are located in a small neighborhood of the origin based on the Lyapunov stability theory and backstepping approach. Finally, the effectiveness of the approach proposed in this paper is proved by simulation results.
Estimating the Weights of Media Tonalities in the Measurement of Media Coverage of Corporations

This study estimates the weights of media tonalities in the measurement of media coverage of corporations by using linear regression analysis. Two new measures—Three Factor Media Favorability (TFMF) index and Four Factor Media Favorability (FFMF) index—are developed based on these estimations. These two measures are compared with other linear function measures of media coverage of corporations. Two types of measures—the measure of media favorability, and the composite measure of media favorability and visibility—are differentiated based on the different roles of media visibility in the formulas. Empirical analyses find that TFMF index and FFMF index have a certain degree of relative advantage over other measures of media favorability in predicting corporate reputation, and a composite measure of media favorability and visibility has a certain degree of relative advantage over the measures of media favorability in predicting corporate reputation. The analyses are based on a content analysis of 2,817 news articles from both the elite newspapers and local newspapers.
Patient cardiovascular risk self-management: results from a randomized trial of motivational interviewing delivered by practice nurses

Abstract Background To enhance cardiovascular risk management and patients’ self-management, a tailored programme to improve cardiovascular risk management was tested in a randomized trial. The presented study concerned secondary analysis. Objectives To explore the correlations of practice nurses’ counselling skills at baseline on chronic illness care (measured with Patient Assessment of Chronic Illness Care questionnaire) and patients’ self-management (assessed with Patient Activation Measure) at follow-up and to examine the effect of the tailored implementation programme on chronic illness care and patients’ self-management. Methods A two-arm cluster randomized trial was conducted in 34 general practices in the Netherlands. Counselling skills of practice nurses at baseline were abstracted from audio-taped consultations, which were assessed by Motivational Interviewing Treatment Integrity. Data of 2184 patients with established cardiovascular disease or at high cardiovascular risk were gathered at inclusion and at 6 months follow-up by a composite questionnaire. Multilevel regression analysis was applied, controlling for patient characteristics. Results Counselling skills of practice nurses were not associated with chronic illness care and patients’ self-management scores. At follow-up, patients in the intervention group experienced less chronic illness care and were less activated in disease management than patients in the control group. The most important predictors were patients’ age, gender and education level. Conclusions The logic model underlying the implementation programme needs to be reconsidered, because patient perceptions were neither influenced by nurses’ counselling skills nor by other components of the implementation programme.
Mean Field Control for Efficient Mixing of Energy Loads

We pose an engineering challenge of controlling an ensemble of energy devices via coordinated, implementation-light, and randomized on/off switching as a problem in nonequilibrium statistical mechanics. We show that mean-field control with nonlinear feedback on the cumulative consumption, assumed available to the aggregator via direct physical measurements of the energy flow, allows the ensemble to recover from its use in the demand response regime, i.e., transition to a statistical steady state, significantly faster than in the case of the fixed feedback. Moreover when the nonlinearity is sufficiently strong, one observes the phenomenon of "super-relaxation," where the total instantaneous energy consumption of the ensemble transitions to the steady state much faster than the underlying probability distribution of the devices over their state space, while also leaving almost no devices outside of the comfort zone.
Reactive Oxygen Species and Gibberellin Acid Mutual Induction to Regulate Tobacco Seed Germination

Seed germination is a complex process controlled by various mechanisms. To examine the potential contribution of reactive oxygen species (ROS) and gibberellin acid (GA) in regulating seed germination, diphenylene iodonium chloride (DPI) and uniconazole (Uni), as hydrogen peroxide (H2O2) and GA synthesis inhibitor, respectively, were exogenously applied on tobacco seeds using the seed priming method. Seed priming with DPI or Uni decreased germination percentage as compared with priming with H2O, especially the DPI + Uni combination. H2O2 and GA completely reversed the inhibition caused by DPI or Uni. The germination percentages with H2O2 + Uni and GA + DPI combinations kept the same level as with H2O. Meanwhile, GA or H2O2 increased GA content and deceased ABA content through corresponding gene expressions involving homeostasis and signal transduction. In addition, the activation of storage reserve mobilization and the enhancement of soluble sugar content and isocitrate lyase (ICL) activity were also induced by GA or H2O2. These results strongly suggested that H2O2 and GA were essential for tobacco seed germination and by downregulating the ABA/GA ratio and inducing reserve composition mobilization mutually promoted seed germination. Meanwhile, ICL activity was jointly enhanced by a lower ABA/GA ratio and a higher ROS concentration.
Resting‐state basal ganglia network codes a motor musical skill and its disruption From dystonia

Background: Musician's dystonia critically impacts professional musicians' careers as they may lose musical skills, which have been acquired through long and intensive training. Yet the pathophysiology of musician's dystonia and its link to the neural mechanisms supporting musical skills is poorly understood. We tested if resting‐state functional connectivity might reflect an aspect of musical skill linked to the pathophysiology of musician's dystonia. We also tested a second hypothesis that the region with altered resting‐state functional connectivity might be correlated with a quantitative measure of musical skills.
Non-vitamin K Antagonist Oral Anticoagulants and Cognitive Impairment in Atrial Fibrillation: Insights From the Meta-Analysis of Over 90,000 Patients of Randomized Controlled Trials and Real-World Studies

Background: The relationship between the use of non-vitamin K antagonist oral anticoagulants (NOACs) and the impairment of cognition in atrial fibrillation (AF) remains unknown. Methods: A comprehensive database search of Medline, Embase, Cochrane Library databases, and ClinicalTrials.gov Website was performed for randomized controlled trials (RCTs) reporting cognitive impairment events and observational nationwide database studies reporting adjusted hazard ratio (HR) in AF patients with NOACs. The primacy outcome was a composite of any cognitive impairment. Summary of HRs and 95% confidence intervals (95%CI) were calculated using the fixed- and random-effects models. Subgroup analyses were undertaken according to the individual NOACs, study types, and duration of follow-up. Results: Finally, eight studies including 97,595 patients (77,643 patients in 6 RCTs and 19,952 patients in 2 observational database studies) met the inclusion criteria, among which 55,337 (56.7%) patients were receiving NOACs and 42,258 (43.3%) patients were receiving vitamin K Antagonists (VKAs) or acetylsalicylic acid. The results showed a borderline significant association between the use of NOACs and the lower risk of cognitive impairment when compared with VKAs/ acetylsalicylic acid (HR: 0.80, 95%CI: 0.63–0.98 for fixed-effects model; HR: 0.77; 95%CI: 0.53–1.01 for random-effects model), with no significant heterogeneity between the studies (I2 = 39.4%, P = 0.12). The results were consistent across the key subgroups (Pinteraction > 0.05 for each). Conclusions: The results indicated that the use of NOACs might lower the tendency on the risk of cognitive impairment in comparison to VKAs/acetylsalicylic acid, and further RCTs and real-world studies are required on an urgent basis to obtain a robust result.
Resistive Nickel Temperature Sensor Integrated Into Short-Gate Length AlGaN/GaN HEMT Dedicated to RF Applications

This letter describes a new method to extract the operating temperature in short-gate length AlGaN/GaN high electron mobility transistors (HEMTs) dedicated to RF applications. For this goal, a nickel resistive sensor is integrated into the HEMT active area close to the hot thermal spot thanks to a well-suited technological process. Operating temperature of the HEMT is extracted showing the capabilities of this method to monitor the thermal behavior of the device. Furthermore, it is shown that dc and RF characteristics are not degraded by additional parasitic capacitance and/or sensor biasing.
Comparison of Disaster Preparedness Between Urban and Rural Community Hospitals in New York State

ABSTRACT Objective The intent of this study was to determine whether there are differences in disaster preparedness between urban and rural community hospitals across New York State. Methods Descriptive and analytical cross-sectional survey study of 207 community hospitals; thirty-five questions evaluated 6 disaster preparedness elements: disaster plan development, on-site surge capacity, available materials and resources, disaster education and training, disaster preparedness funding levels, and perception of disaster preparedness. Results Completed surveys were received from 48 urban hospitals and 32 rural hospitals.There were differences in disaster preparedness between urban and rural hospitals with respect to disaster plan development, on-site surge capacity, available materials and resources, disaster education and training, and perception of disaster preparedness. No difference was identified between these hospitals with respect to disaster preparedness funding levels. Conclusions The results of this study provide an assessment of the current state of disaster preparedness in urban and rural community hospitals in New York. Differences in preparedness between the two settings may reflect differing priorities with respect to perceived threats, as well as opportunities for improvement that may require additional advocacy and legislation. (Disaster Med Public Health Preparedness. 2019;13:424-428)
Injury Prevention Programs Based on Flywheel vs. Body Weight Resistance in Recreational Athletes.

Monajati, A, Larumbe-Zabala, E, Sampson, MG, and Naclerio, F. Injury prevention programs based on flywheel vs. body weight resistance in recreational athletes. J Strength Cond Res XX(X): 000-000, 2018-This study compares the effect of an isoinertial flywheel technology vs. a traditional gravity-dependent exercise protocol on modifiable factors associated with the incidence of hamstring strain (HAM) and anterior cruciate ligament (ACL) injuries. Furthermore, the effect on repeated sprint ability was also considered. Eighteen recreationally trained volleyball players completed one of the following 6-week protocols: (a) flywheel (FY) included 3 exercises using a YoYo isoinertial-squat machine and 3 exercises with a Versa-Pulley isoinertial device, and (b) gravity-dependent (GT) involved 6 similar exercises with no external resistance (participants' body weight). Both programs consisted in 2 sessions·wk performing 2 sets of 8 repetitions with 2 minutes of rest. Outcomes included a 10-second tuck jump assessment (TJA), landing knee valgus score, hamstring and quadriceps concentric and eccentric isokinetic 60°·s peak torque, optimal peak torque localization, conventional and functional hamstring-to-quadriceps ratio, and 10-m repeated shuttle sprint ability (RSSA) test. FY improved TJA (-2, interquartile range [IQR] = -3 to -1) and valgus (-1, IQR = -1 to 0) scores, hamstring eccentric (20.37, 95% confidence interval [CI] = 9.27-31.47 N·m) and concentric (17.87, 95% CI = 0.40-35.34 N·m) peak torque, as well as the RSSA (-0.28, 95% CI = -0.45 to -0.10 seconds), whereas GT only improved hamstring eccentric peak torque (21.41, 95% CI = 9.00-33.82 N·m). A 6-week protocol using flywheel technology seems to elicit better positive adaptations to protect athletes from HAM and ACL injuries and to enhance RSSA performance compared to exercising with no external resistance other than athletes' body weight.
A New Method for Detection of Phishing Websites: URL Detection

Phishing is an unlawful activity wherein people are misled into the wrong sites by using various fraudulent methods. The aim of these phishing websites is to confiscate personal information or other financial details for personal benefits or misuse. As technology advances, the phishing approaches used need to get progressed and there is a dire need for better security and better mechanisms to prevent as well as detect these phishing approaches. The primary focus of this paper is to put forth a model as a solution to detect phishing websites by using the URL detection method using Random Forest algorithm. There are 3 major phases such as Parsing, Heuristic Classification of data, Performance Analysis in this model and each phase makes use of a different technique or algorithm for processing of data to give better results.
Diet-Modulated Lipoprotein Metabolism and Vascular Inflammation Evaluated by 18F-fluorodeoxyglucose Positron Emission Tomography

Vascular inflammation plays a central role in atherosclerosis, from initiation and progression to acute thrombotic complications. Modified low-density lipoproteins (LDLs) and apoB-containing particles stimulate plaque inflammation by interacting with macrophages. Loss of function of high-density lipoprotein (HDL) for preventing LDL particles from oxidative modification in dyslipidemic states may amplify modified LDL actions, accelerating plaque inflammation. Diets are one of the most important factors that can affect these processes of lipoprotein oxidation and vascular inflammation. Recently, 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has emerged as a reliable noninvasive imaging modality for identifying and quantifying vascular inflammation within atherosclerotic lesions based on the high glycolytic activity of macrophages infiltrating active atherosclerotic plaques. Vascular inflammation evaluated by FDG PET has been positively related to metabolic syndrome components and traditional risk factors of cardiovascular disease, including high-sensitivity C-reactive protein, body mass index, and insulin resistance. A positive association of vascular inflammation with endothelial dysfunction, resistin levels, pericardial adipose tissue, and visceral fat area has also been reported. In contrast, HDL cholesterol and adiponectin have been inversely related to vascular inflammation detected by FDG PET. Because of its reproducibility, serial FDG PET shows potential for tracking the effects of dietary interventions and other systemic and local antiatherosclerotic therapies for plaque inflammation.
Long-Term Clinical Experience with Selectively Constrained SECURE-C Cervical Artificial Disc for 1-Level Cervical Disc Disease: Results from Seven-Year Follow-Up of a Prospective, Randomized, Controlled Investigational Device Exemption Clinical Trial

ABSTRACT Background: This research was initiated to compare the long-term clinical safety and effectiveness of the selectively constrained SECURE-C (Globus Medical, Audubon, Pennsylvania) Cervical Artificial Disc to anterior cervical discectomy and fusion (ACDF). To preserve segmental motion, cervical total disc replacement (CTDR) was developed as an alternative to ACDF. Current CTDR designs incorporate constrained and unconstrained metal-on-metal or metal-on-polymer articulation with various means of fixation. Methods: Eighteen investigational sites participated in this prospective clinical trial; 380 patients were enrolled and treated in the investigational device exemption study. The first 5 patients treated at each site were nonrandomized and received the investigational SECURE-C device. Patients were randomized, treated surgically, and evaluated postoperatively at 6 weeks, 3 months, 6 months, 12 months, 24 months, and annually thereafter through 84 months postoperative. Results: Overall results for the randomized cohorts demonstrated statistical superiority of the investigational SECURE-C group over the control ACDF group at 84 months postoperative. SECURE-C showed clinically significant improvement in pain and function in terms of neck disability index and visual analog scale scores, and superiority in patient satisfaction was also achieved for patients treated with SECURE-C. Conclusion: Clinical study results indicated that the selectively constrained SECURE-C Cervical Artificial Disc is as safe and effective as ACDF. Long-term results from the Post Approval Study demonstrated that SECURE-C is statistically superior to ACDF in terms of overall success and patient satisfaction. Lower rates of subsequent index-level surgeries and device-related adverse events were observed in the SECURE-C group than in the ACDF group. The long-term, level 1 clinical evidence presented here is consistent with other reports supporting the safety and efficacy of cervical arthroplasty, and furthers advocacy for motion preservation as a viable alternative to fusion.
Evaluation of Galactomannan Testing, the Aspergillus-Specific Lateral-Flow Device Test and Levels of Cytokines in Bronchoalveolar Lavage Fluid for Diagnosis of Chronic Pulmonary Aspergillosis

Background: Diagnosis of chronic pulmonary aspergillosis (CPA) is challenging. Symptoms are unspecific or missing, radiological findings are variable and proof of mycological evidence is limited by the accuracy of diagnostic tests. The goal of this study was to investigate diagnostic performance of galactomannan (GM), the newly formatted Aspergillus-specific lateral-flow-device test (LFD), and a number of cytokines in bronchoalveolar lavage fluid (BALF) samples obtained from patients with CPA, patients with respiratory disorders without CPA and healthy individuals. Methods: Patients with CPA (n = 27) and controls (n = 27 with underlying respiratory diseases but without CPA, and n = 27 healthy volunteers) were recruited at the Medical University of Graz, Austria and the Research Center Borstel, Germany between 2010 and 2018. GM, LFD and cytokine testing was performed retrospectively at the Research Center Borstel. Results: Sensitivity and specificity of GM testing from BALF with a cut off level of ≥0.5 optical density index (ODI) was 41 and 100% and 30 and 100% with a cut off level of ≥1.0 ODI. ROC curve analysis showed an AUC 0.718 (95% CI 0.581–0.855) for GM for differentiating CPA patients to patients with other respiratory diseases without CPA. The LFD resulted positive in only three patients with CPA (7%) and was highly specific. CPA patients did not differ significantly in the BALF cytokine profile compared to patients with respiratory disorders without CPA, but showed significant higher values for IFN-γ, IL-1b, IL-6, IL-8, and TNF-α compared to healthy individuals. Conclusion: Both GM and LFD showed insufficient performance for diagnosing CPA, with sensitivities of BALF GM below 50%, and sensitivity of the LFD below 10%. The high specificities may, however, result in a high positive predictive value and thereby help to identify semi-invasive or invasive disease.
Deriving a State Model of a Control Program by Symbolic Execution

This paper presents an approach for deriving a state transition model which represents the behavior of a control component using symbolic execution. Symbolic execution is a technique for executing a program using symbolic values for unknowns. It explores execution paths in a program and then uses a SAT/SMT solver to prove that paths are feasible. Further, the approach allows using constraints on the environment and simplifications with a widening operator similar to abstract interpretation.We present the formal foundation of the approach, depict the the tool implementation, present results from a preliminary evaluation, and discuss various application scenarios.
Dislocation of the Hip: A Review of Types, Causes, and Treatment

Background: Dislocation of the hip is a well-described event that occurs in conjunction with high-energy trauma or postoperatively after total hip replacement. Methods: In this review, the types, causes, and treatment modalities of hip dislocation are discussed and illustrated, with particular emphasis on the assessment, treatment, and complications of dislocations following total hip replacement. Results: Hip dislocations are commonly classified according to the direction of dislocation of the femoral head, either anterior or posterior, and are treated with specific techniques for reduction. Generally, closed reduction is the initial treatment method, usually occurring in the emergency room. Bigelow first described closed treatment of a dislocated hip in 1870, and since then many reduction techniques have been proposed. Each method has unique advantages and disadvantages. Anterior hip dislocation is commonly reduced by inline traction and external rotation, with an assistant pushing on the femoral head or pulling the femur laterally to assist reduction. Posterior hip dislocations are the most common type and are reduced by placing longitudinal traction with internal rotation on the hip. Conclusion: Patients with hip dislocations must receive careful diagnostic workup, and the treating physician must be well versed in the different ways to treat the injury and possible complications. Timely evaluation and treatment, including recognizing the potential complications, are necessary to offer the best outcome for the patient.