Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings

Objective: The effects of aging on the presentation of HIV-associated neurocognitive disorders are largely unknown. In a cross-sectional observational study, we compared the neuropsychological profiles of 67 HIV-positive patients aged at least 50 years with those of 52 participants aged 35 years or less. Methods: Participants received neuropsychological, psychiatric and neuromedical evaluations. Raw neuropsychological test scores were converted to demographically corrected T-scores; all were corrected for the effects of normal aging. Clinical ratings of impairment were assigned to the neuropsychological results. Results: The two groups did not differ statistically with respect to demographic variables, percentage with AIDS, or CD4 cell counts. The ‘younger’ group had higher viral burdens in plasma and cerebrospinal fluid (CSF), and fewer were receiving antiretroviral treatment. The proportion of neuropsychologically impaired subjects in the ‘older’ group was slightly greater than in the younger group, and the older group tended to have higher rates of impairment across most ability domains. When group differences in CSF viral load were modeled statistically, both viral burden and age were significant predictors of neuropsychological impairment, together with a significant interaction between viral burden and age. Older individuals with detectable virus in CSF had twice the prevalence of neuropsychological impairment of those with undetectable levels. Among younger individuals, this proportion was not affected by viral load. Lifetime major depression, substance use disorder, and current depression symptoms were not associated with neuropsychological impairment. Conclusion: Although further studies with larger and older samples are needed, this investigation suggests that older adults may be at greater risk of HIV-related neurocognitive dysfunction.
Cell Type-Specific Quantitative Predictions of Radiation-Induced Chromosome Aberrations: A Computer Model Approach

Abstract Kreth, G. , Pazhanisamy, S. K. , Hausmann, M. and Cremer, C. , Cell Type-Specific Quantitative Predictions of Radiation-Induced Chromosome Aberrations: A Computer ModelApproach. Radiat. Res. 167, 515–525 (2007). A quantitative computer model was applied to simulate the three-dimensional (3D) spatial organization of chromatin in human cell nuclei under defined conditions of virtual irradiation to explore the implications of spatial organization on chromosome aberrations. To calibrate the virtual irradiation algorithm, a dose-dependent spectrum of radiation-induced chromosome aberrations such as dicentrics, translocations and centric rings was calculated for low-LET radiation doses ranging from 0.5 to 5 Gy. This was compared with the results from experimental studies. While the dose–response curves calculated from model simulations agree well with experimental dose–response curves for dicentrics and translocations, centric rings are significantly more frequent in the model simulation than in experiments despite taking into account exclusive arm territories in the applied Spherical 1 Mbp Chromatin Domain (SCD) computer model explicitly. Taking into account the non-random positioning of chromosome territories observed in lymphocyte cell nuclei (a so-called gene density-correlated arrangement of chromosome territories), aberration frequencies were calculated with the calibrated irradiation algorithm to investigate the impact of chromosome territory neighborhood effects (proximity effects). The absolute frequencies of pairwise exchanges agree well with those found in an experimental study. In conclusion, the results obtained using the computer model approach presented here based on only a few adjustable parameters correlated well with those of experimental studies of chromosome aberration frequencies. Thus the model may be a useful tool in radiation-induced cancer risk estimates in combination with epidemiological studies.
Total quality management and sustainable competitive advantage: serial mediation of transformational leadership and executive ability

Improving performance through better processes should be the focus of quality professionals. Based on the IPO (Input-Process-Output) model, this study considers total quality management (TQM) as an input of the internal and external of an organisation and transformational leadership (TL) and executive ability (EA) as the mechanism (Process) to promote and coordinate internal–external elements for the organisation obtaining its sustainable competitive advantage (SCA) (Output). Taking samples in the southern Taiwan Science Park in Tainan city for the questionnaire survey in this study, a total of 252 valid responses are collected and analysed to discuss the relationships among TQM, TL, EA and SCA. Reliability analysis, validity analysis, CFA and SEM are utilised for the analyses. The research findings are summarised as follows: (1) TQM significantly affects TL, EA and SCA. (2) TL and EA significantly affect a firm’s SCA and each of them has the mediating effect between TQM and SCA. (3) Both of them have a serial mediating effect on the relationship between TQM and SCA. Implications, limitations and future research directions are discussed.
PRINSIP-PRINSIP MUAMALAH DALAM ISLAM

Praktek curang dalam muamalah(mengambil keuntungan sepihak tanpa menghiraukan kerugian pihak pembeli), menjual barang tidak sesuai dengan promosi, bahkan tak jarang mereka mengurangi timbangan sangat masif terjadi. Lebih jauh dinamika pengembangan harta yang bersifat eksploitatif terhadap kelompok lain pun sering terjadi, dan disinyalir keuntunganlah yang menjadi prima klausanya. Padahal menjaga prinsip-prinsip muamalah secara berkelanjutan, akan diikuti oleh keuntungan yang seimbang antara penjual dan pembeli. Pembahasan ini akan menjelaskan secara deskriptif prinsip prinsip muamalah . Pembahasan ini juga akan mengangkat kajian berkaitan prinsip dan asas dalam muamalah. Ketentuan dan batasan muamalah hakikatnya adalah mendatangkan segala mashlahah untuk kita dan menghilangkan segala ke madhorroh. Seperti halnya Allah mengharamkan praktek riba karena terdapat banyak madhorroh didalamnya, bahkan untuk aspek makro ekonomi dapat menyebabkan kehancuran sistemik terhadap masyarakat bahkan terhadap negara. Kata Kunci : Muamalah, prinsip, maslahah . Abstract Fraudulent practices in muamalah (taking unilateral benefits regardless of the loss of the buyer), selling goods not in accordance with the promotion, even not infrequently they reduce the scale is very massive occurs. Furthermore, the dynamics of exploitative development of property against other groups are also common, and it is assumed that profit is the prime of the clause. While keeping the principles of muamalah in a sustainable, will be followed by a balanced profit between sellers and buyers. This discussion will explain descriptively the principles of muamalah. This discussion will also raise the study of principles and principles in muamalah. The provisions and limitations of muamalah essence is to bring all mashlahah for us and remove everything to madhorroh. Just as Allah forbids the practice of usury because there are many madhorroh in it, even for macroeconomic aspects can lead to systemic destruction of society even to the state. Keyword: Muamalah, principle, maslahah.
Population Structure and Properties of Candida albicans, as Determined by Multilocus Sequence Typing

ABSTRACT We submitted a panel of 416 isolates of Candida albicans from separate sources to multilocus sequence typing (MLST). The data generated determined a population structure in which four major clades of closely related isolates were delineated, together with eight minor clades comprising five or more isolates. By Fisher's exact test, a statistically significant association was found between particular clades and the anatomical source, geographical source, ABC genotype, decade of isolation, and homozygosity versus heterozygosity at the mating type-like locus (MTL) of the isolates in the clade. However, these associations may have been influenced by confounding variables, since in a univariate analysis of variance, only the clade associations with ABC type and anatomical source emerged as statistically significant, providing the first indication of possible differences between C. albicans strain type clades and their propensity to infect or colonize different anatomical locations. There were no significant differences between clades with respect to distributions of isolates resistant to fluconazole, itraconazole, or flucytosine. However, the majority of flucytosine-resistant isolates belonged to clade 1, and these isolates, but not flucytosine-resistant isolates in other clades, bore a unique mutation in the FUR1 gene that probably accounts for their resistance. A significantly higher proportion of isolates resistant to fluconazole, itraconazole, and flucytosine were homozygous at the MTL, suggesting that antifungal pressure may trigger a common mechanism that leads both to resistance and to MTL homozygosity. The utility of MLST for determining clade assignments of clinical isolates will form the basis for strain selection for future research into C. albicans virulence.
Cimetidine‐Induced Hemolytic Anemia: The Fallacy of Clinical Associations

Two patients developed hemolytic anemia while taking cimetidine. Neither patient was taking other drugs known to cause hemolytic anemia. In both, the hemolytic anemia resolved after the drug was stopped. In one patient, the direct antiglobulin (Coombs') test was strongly positive when the hemolytic anemia was recognized and became only weakly positive as the hemolysis subsided. However, serologic studies for antidrug antibodies yeilded negative results in both patients; readministration of cimetidine for 55 days in patient 1 and for more than 24 months in patient 2 did not cause recurrence of hemolysis. We conclude that we cannot incriminate cimetidine as the cause of the bemolytic anemia in either of our patients. These findings emphasize that a temporal association of drug administration and hemolytic anemia is not proof of a cause-effect relationship and that reports of drug-related adverse hematologic effects must be interpreted with caution.
Elucidating the Behavior of Consumers toward Online Grocery Shopping: The Role of Shopping Orientation

Abstract This research examined the factors affecting consumer buying intention in the online grocery market in Thailand. The conceptual framework incorporates the theories of technology adoption and shopping behavior, including the technology acceptance model, consumer shopping orientation, and online shopping experience. The study was conducted as a quantitative online self-administered survey of Thai consumers who had bought groceries online. The sample was primarily female, younger than 40 years of age, and highly educated. Most participants were infrequent online grocery buyers (once a month or less). The data were analyzed using structural equation modeling. The findings showed that the technology acceptance model variables had the strongest effect on attitude for online shopping, although all hypotheses were accepted. The predictive value of attitude for the online buying intention for groceries was very high. The implication of this research is that online shopping is both a technology decision and a consumer decision and needs to be examined as such.
Plasma membrane localization and function of the estrogen receptor α variant (ER46) in human endothelial cells

Estrogen receptor (ER) α variants have been identified in an array of nonendothelial cells. We previously demonstrated that estrogen rapidly induces nitric oxide release via a phosphatidylinositol 3-kinase/Akt/endothelial nitric-oxide synthase (eNOS) pathway in EA.hy926 cells (immortalized human endothelial cells), which express a 46-kDa ER. We now confirm that, due to alternative splicing, the 46-kDa endothelial cell protein (ER46) is an amino-terminal truncated product of full-length ERα (ER66). ER46 is expressed in the plasma membrane, cytosol, and nucleus of resting, estrogen-deprived cells. Flow cytometric and immunofluorescence microscopic analyses demonstrated that the ER46 C but not N terminus is Ab-accessible in the plasma membrane. Inhibition of palmitoylation with tunicamycin and [3H]palmitic acid labeling demonstrated an estrogen-induced, palmitoylation-dependent plasma membrane ER46 recruitment, with reorganization into caveolae. In reconstituted, estrogen-stimulated COS-7 (ER-null) cells, membrane ER46 more efficiently triggered membrane eNOS phosphorylation than ER66. Conversely, ER66 more efficiently mediated estrogen response element reporter-gene transactivation than ER46. These results demonstrate that ER46 is localized and further dynamically targeted to the plasma membrane in a palmitoylation-dependent manner. ER46 more efficiently modulates membrane-initiated estrogen actions, including eNOS activation, than full-length ER66. These findings may have important implications in vascular-specific targeting of estrogen receptor agonists.
Recurrent Exophytic Meningioma in Pregnancy

BACKGROUND: Meningiomas are slow-growing tumors that may present in pregnancy because of accelerated growth. We present the case of a recurrent meningioma in two separate pregnancies in the same woman. CASE: A 35-year-old woman presented at 30 weeks of gestation with limb weakness, vomiting, and a progressive decreased level of consciousness with an enlarging forehead mass. Imaging revealed a massive extra-axial exophytic tumor. An emergency craniotomy was performed, complicated by massive blood loss. Final pathology showed a grade I meningioma positive for progesterone receptors. Maternal–fetal outcome was good, with return of normal neurologic status and elective delivery at 38 weeks of gestation. CONCLUSION: Pregnancy is associated with accelerated meningioma growth and recurrence. Treatment during pregnancy is possible and requires a multidisciplinary approach.
From offline healthcare to online health service : the role of offline healthcare satisfaction and habits

With the rapidly growing popularity of the delivery of health services through the Internet, it is timely to examine online health service (OHS) diffusion from the human decision process perspective for its development and diffusion. The health service possesses an offline-to-online nature; that is, its online service is an extension of its offline service. Therefore, we develop a research model to bridge offline healthcare and the OHS-decision, which is contingent on different levels of offline healthcare habits, drawing on user satisfaction literature, the Innovation Diffusion Theory, and the habit literature. Data were collected from 323 Internet users, and our empirical results show that high satisfaction on offline healthcare hinders the awareness of OHS and subsequently influences adoption intention. On the other hand, offline healthcare habits weaken the effects of offline health satisfaction on the OHS awareness. Discussions and implications are also proposed in the concluding sections of this research.
Late Mousterian Persistence near the Arctic Circle

Artefacts at a site in the northern Urals dating to about 33,000 years ago suggest a last northern refuge of Neandertals. Palaeolithic sites in Russian high latitudes have been considered as Upper Palaeolithic and thus representing an Arctic expansion of modern humans. Here we show that at Byzovaya, in the western foothills of the Polar Urals, the technological structure of the lithic assemblage makes it directly comparable with Mousterian Middle Palaeolithic industries that so far have been exclusively attributed to the Neandertal populations in Europe. Radiocarbon and optical-stimulated luminescence dates on bones and sand grains indicate that the site was occupied during a short period around 28,500 carbon-14 years before the present (about 31,000 to 34,000 calendar years ago), at the time when only Upper Palaeolithic cultures occupied lower latitudes of Eurasia. Byzovaya may thus represent a late northern refuge for Neandertals, about 1000 km north of earlier known Mousterian sites.
GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol

The neurotransmitter GABA mediates the majority of rapid inhibition in the CNS. Inhibition can occur via the conventional mechanism, the transient activation of subsynaptic GABAA receptors (GABAA-Rs), or via continuous activation of high-affinity receptors by low concentrations of ambient GABA, leading to “tonic” inhibition that can control levels of excitability and network activity. The GABAA-R α4 subunit is expressed at high levels in the dentate gyrus and thalamus and is suspected to contribute to extrasynaptic GABAA-R-mediated tonic inhibition. Mice were engineered to lack the α4 subunit by targeted disruption of the Gabra4 gene. α4 Subunit knockout mice are viable, breed normally, and are superficially indistinguishable from WT mice. In electrophysiological recordings, these mice show a lack of tonic inhibition in dentate granule cells and thalamic relay neurons. Behaviorally, knockout mice are insensitive to the ataxic, sedative, and analgesic effects of the novel hypnotic drug, gaboxadol. These data demonstrate that tonic inhibition in dentate granule cells and thalamic relay neurons is mediated by extrasynaptic GABAA-Rs containing the α4 subunit and that gaboxadol achieves its effects via the activation of this GABAA-R subtype.
The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis

Alzheimer's disease (AD) is a devastating neurodegenerative disease and there is no effective therapy for it. Peroxisome proliferators activated receptor-gamma (PPAR-γ) agonists is a promising therapeutic approach for AD and has been widely studied recently, but no consensus was available up to now. To clarify this point, a meta-analysis was performed. We searched MEDLINE, EMBASE, Cochrane Central database, PUBMED, Springer Link database, SDOS database, CBM, CNKI and Wan fang database by December 2014. Standardized mean difference (SMD), relative risk (RR) and 95% confidence interval (CI) were calculated to assess the strength of the novel therapeutics for AD and mild-to-moderate AD. A total of nine studies comprising 1314 patients and 1311 controls were included in the final meta-analysis. We found the effect of PPAR-γ agonists on Alzheimer's Disease Assessment Scale – Cognitive Subscale (ADAS-cog) scores by using STATA software. There was no evidence for obvious publication bias in the overall meta-analysis. There is insufficient evidence of statistically incognition of AD and mild-to-moderate AD patients have been improved who were treated with PPAR-γ agonists in our research. However, PPAR-γ agonists may be a promising therapeutic approach in future, especially pioglitazone, with large-scale randomized controlled trials to confirm.
Recent trends in research on teacher–child relationships

Theoretical and empirical work on relationships between teachers and children relies on developmental systems theory as the foundational conceptual model, drawing heavily from basic work in attachment as well as research on social development. Recently, the focus on relational processes in effort to support children's development in the classroom has proliferated, with multiple disciplines and fields engaging in research on teacher–child relationship quality to understand and improve the experiences and learning of students. This paper updates the conceptual framework and continues the necessary integration between disciplines by exploring three areas of research: (1) concordance between children's relationships with teachers and parents; (2) the moderating role of teacher–child relationships for the development of at-risk children; and (3) training teachers from a relational perspective. Each of the three areas of research on teacher–child relationships is examined in light of recent findings and considers implications for understanding the nature and impact of relationships between teachers and children.
Altererythrobacter namhicola sp. nov. and Altererythrobacter aestuarii sp. nov., isolated from seawater.

Two non-motile, orange- or yellow-pigmented bacteria, designated strains KYW48(T) and KYW147(T), were isolated from seawater collected from the South Sea, Republic of Korea. Cells of both strains were Gram-reaction-negative, aerobic and catalase- and oxidase-positive. The major fatty acids of strain KYW48(T) were C(18 : 1)ω7c (35.3 %), summed feature 3 (iso-C(15 : 0) 2-OH and/or C(16 : 1)ω7c) (22.7 %), C(17 : 1)ω6c (19.8 %), C(14 : 0) 2-OH (7.4 %) and C(16 : 0) (5.9 %), and those of strain KYW147(T) were C(18 : 1)ω7c (36.0 %), summed feature 3 (18.3 %), C(16 : 0) (14.7 %), 11-methyl C(18 : 1)ω7c (10.7 %), C(16 : 0) 2-OH (9.1 %) and C(18 : 1)ω9c (8.0 %). The predominant isoprenoid quinone of both strains was ubiquinone 10 (Q-10). The DNA G+C contents of strains KYW48(T) and KYW147(T) were 63.8 and 67.2 mol%, respectively. A phylogenetic tree based on 16S rRNA gene sequences showed that strains KYW48(T) and KYW147(T) were grouped with the members of the family Erythrobacteraceae and formed a distinct clade with the members of the genus Altererythrobacter (<95.7 % sequence similarity). On the basis of the evidence presented in this study, the novel species Altererythrobacter namhicola sp. nov. (type strain KYW48(T) = KCTC 22736(T) = JCM 16345(T)) and Altererythrobacter aestuarii sp. nov. (type strain KYW147(T) = KCTC 22735(T) = JCM 16339(T)) are proposed.
Cytotoxic immune response after retroviral-mediated hepatic gene transfer in rat does not preclude expression from adeno-associated virus 1 transduced muscles.

Intravenous delivery of nls-lacZ retroviral vectors to the regenerating liver triggers a cytotoxic immune response directed against transduced hepatocytes. We sought to determine whether prior immunization with retroviral vectors impacted on adeno-associated virus (AAV)-mediated muscular expression of the same transgene. The first group of rats first received nls-lacZ retroviral vectors intravenously after a partial hepatectomy. Thirty days later they received AAV vectors intramuscularly in both legs. In the second group, animals received the same vectors in the opposite sequence (i.e., AAV first and retroviruses 20 days later). In the first group, immune response occurred after retrovirus delivery with appearance of anti-beta-galactosidase antibodies and elimination of transduced hepatocytes. However, the immune response did not prevent sustained (9-month) beta-galactosidase expression in AAV-injected muscles. In the second group, AAV injections did not induce immune response and resulted in beta-galactosidase expression in myofibers. In this group, subsequent delivery of retroviral vectors triggered appearance of immune response and elimination of transduced hepatocytes. However, the immune response did not modify beta-galactosidase expression in AAV-transduced myofibers for up to 9 months. These results demonstrate a differential susceptibility between retrovirally transduced liver and AAV-transduced muscles to immune response against the transgene product.