Miracle-dz/UniFAR-FTUs huggingface dataset:
Representações maternas: teóricos e possibilidades de avaliação e intervenção clínica

As representacoes maternas englobam expectativas, fantasias e desejos da mae sobre o bebe, assim como os aspectos transgeracionais ligados a isso. O objetivo do presente artigo e abordar essas representacoes, destacando as representacoes da mulher sobre a sua propria mae e sobre o bebe. Alem disso, buscou-se apresentar as possibilidades de avaliacao e intervencao clinica sobre essas representacoes, segundo a perspectiva psicanalitica. Ressalta-se que a exploracao das representacoes maternas constitui uma importante ferramenta da clinica pais-bebe, auxiliando na melhoria da qualidade dessa relacao. Em decorrencia disso, tal investigacao poderia ser mais utilizada tanto no contexto clinico como de pesquisa.
Further evidence for linkage of autosomal-dominant medullary cystic kidney disease on chromosome 1q21.

BACKGROUND Autosomal-dominant medullary cystic kidney disease (ADMCKD) is characterized by the development of cysts at the corticomedullary border of the kidneys. It resembles nephronophthisis (NPH) with an autosomal-recessive mode of inheritance. Genetic linkage has been shown either on chromosome 1q21 (ADMCKD1) or 16p12 (ADMCKD2), and families exist who are not linked to the aforementioned loci. No disease-causing gene underlying this disorder has been reported. METHODS The Finnish Transplantation Register and hospital records were searched to identify all of the ADMCKD families in the Finnish population. Detailed clinical information of the patients was collected. Linkage analysis was used to study whether the Finnish families originating from a homogeneous population showed genetic linkage to the ADMCKD1 or ADMCKD2 loci. Also, the coding region of a strong candidate gene, natriuretic peptide receptor A (NPRA), located on the chromosome 1q21 critical region, was sequenced using polymerase chain reaction sequencing with an ABI 377XL Automated DNA sequencer (Applera Corp., Norwalk, CT, USA). RESULTS Five of the six families showed linkage to the previously identified region of chromosome 1q21. Family 6 with hyperuricemia as a prominent clinical feature was linked to neither of the ADMCKD loci. Wide interfamiliar and intrafamiliar variability in the clinical picture of the patients was detected. The NPRA gene mutation was excluded as a causative gene by sequencing. CONCLUSION This study locates the gene for ADMCKD1 close to a marker D1S1595 in a region <5 cM, and further confirms the existence of at least three loci for the medullary cystic kidney disease. Heterogeneity of the symptoms complicates the clinical diagnosis and classification of the patients. Further studies are needed to identify the disease-causing gene.
A model to classify the sedative load of drugs

T. Linjakumpu*, S. Hartikainen, T. Klaukka, H. Koponen, S. -L. Kivelä and R. Isoaho Department of Psychiatry, University of Oulu, Finland Department of Public Health and General Practice, Division of Geriatrics, University of Kuopio, Municipal Hospitals of Kuopio, Finland Research and Development Centre of the Social Insurance Institution, Helsinki, Finland Department of Psychiatry, University of Oulu, Department of Psychiatry, Hospital District of Lapland, Rovaniemi, Finland Institute of Clinical Medicine, General Practice, University of Turku, Satakunta Central Hospital, Pori, Finland Institute of Clinical Medicine, General Practice, University of Turku, Härkätie Health Center, Lieto, Finland
Dilated LMI conditions for time-varying polytopic descriptor systems: the discrete-time case

This article addresses the admissibility analysis and state-feedback control synthesis problems of discrete-time polytopic descriptor systems with possibly time-varying parameters. First, we present a new necessary and sufficient strict linear matrix inequality (LMI) condition for the admissibility analysis of linear time-invariant (LTI) descriptor systems. Then, based on the concept of poly-quadratic admissibility, introduced in this article, we extend this result to the admissibility analysis of possibly time-varying parameter-dependent descriptor systems. This extension, which applies to both uncertain and measurable parameters, uses parameter-dependent Lyapunov functions and employs two slack variables. The extended conditions are also expressed as strict LMI conditions which are easily tractable numerically compared to the non-strict ones often encountered when dealing with descriptor systems. Note that we have proposed two separate admissibility analysis conditions: one directly exploitable for state estimation and the other for state-feedback control. The need for different admissibility analysis conditions for each synthesis problem is motivated by the fact that the duality between state estimation and state-feedback control, which hold in the case of measurable parameters, does not hold when dealing with uncertain ones. In our approach, we overcome the absence of such duality by considering a dilation only on the dynamical part of the descriptor system. The application of our analysis result to both robust state-feedback control and polytopic state-feedback control are also presented in this article. Our analysis results extend to descriptor systems, some existing results developed for regular systems.
The (−1486T/C) promoter polymorphism of the TLR‐9 gene is associated with end‐stage knee osteoarthritis in a Chinese population

Based on the recent observation that Toll‐like receptors (TLRs) may be involved in the pathogenesis of osteoarthritis (OA) we explored the possibility that human TLR gene polymorphisms are associated with OA. Two separate populations were studied in a two‐stage case–control study with a total of 503 OA patients and 428 healthy controls. The TLR‐2, TLR‐4, and TLR‐9 genotypes were assessed by real‐time polymerase chain reaction. Our data demonstrated a lack of association among TLR‐2, TLR‐4, and TLR‐9 (T‐1237C) polymorphisms and the risk of developing OA in both stages of the study. T‐1486C was significantly associated with OA in both populations with G1635A of TLR‐9 gene was found to be significantly associated with OA when the two populations were combined. Stratifying the samples by K‐L score there were significant differences in the genotype of the TLR‐9 T‐1486C and G1635A between OA of the knee grade 4 and controls. In haplotype analyses, the haplotype TTG and TTA revealed higher risk of OA and TCA confers a lower risk of OA in combined population. The present results demonstrate that TLR‐9 polymorphisms, in particular T‐1486C is significantly associated with OA. TLR‐9 gene polymorphisms may play a role in the etiology of knee OA. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:9–14, 2012
Test of Dufrêne's production model on two contrasting families of oil palm in North Sumatra

Les resultats de la simulation realisee en Cote d'Ivoire par Dufrene (1990) sur la famille L2TxD10D ont montre une grande compatibilite avec les observations en champ sur des palmiers non soumis aux stress hydrique ou nutritif. Pour verifier l'applicabilite du modele aux conditions de l'Indonesie, 14 parametres physiologiques et biometriques ont ete etudies chez 2 familles dont l'une originaire de La Me et l'autre locale. Lors d'une premiere comparaison ne prenant en compte que la difference de radiation entre les deux pays, on a observe une augmentation annuelle theorique de 4 % des assimilats, une baisse de 2 % de la respiration, un gain de 18 % de la production annuelle de matiere seche et de pres de 80 % du poids de FFB. En integrant les donnees meteorologiques de l'Indonesie et les caracteristiques des varietes, on a obtenu des rendements theoriques de 40,1 t FFB/ha pour la var. "Lame" contre 35,8 pour la var. locale, pour des rendements observes d'environ 24 et 17 t respectivement. La difference pourrait s'expliquer par des degâts d'insectes defoliateurs, ou par les effets des frequentes inondations sur le systeme racinaire
The Effect of Mobile Portfolio (M-Portfolio) Supported Mastery Learning Model on Students’ Achievement and Their Attitudes towards Using Internet

The term mobile portfolio refers to creating, evaluating and sharing portfolios in mobile environments. Many of the states that pose an obstacle for portfolio usage are now extinguished through mobile portfolios. The aim in this research is to determine the effect of mobile portfolio supported mastery learning model on students’ success and attitudes towards using internet. The research was carried out in the Academic Year 2014-2015 with students, taking Computer-I course at Primary School Teacher Education and Social Sciences Teaching Departments in Faculty of Education in Siirt University. The Internet Usage Attitudes Scale developed by Tavsancil & Keser (2002), was used to determine student attitudes towards internet usage. The scale was prepared as a five point Likert type scale. An academic achievement test developed by researchers was used to determine achievement of course. The data analysis methods used in this study were average, standard deviation, independent groups t-test and dependent groups t-test. As a result of research, the effect of mobile portfolio supported mastery learning model on students’ academic achievement was found to be positive. Furthermore, use of mobile portfolio among students tested in research, a positive increase was seen in their attitudes towards internet use. As a result of the data analysis, this difference shows no significant difference. According to the findings recommendations have been made.
PTF1 J191905.19+481506.2—A PARTIALLY ECLIPSING AM CVn SYSTEM DISCOVERED IN THE PALOMAR TRANSIENT FACTORY

We report on PTF1 J191905.19+481506.2, a newly discovered, partially eclipsing, outbursting AM CVn system found in the Palomar Transient Factory synoptic survey. This is only the second known eclipsing AM CVn system. We use high-speed photometric observations and phase-resolved spectroscopy to establish an orbital period of 22.4559(3) minutes. We also present a long-term light curve and report on the normal and super-outbursts regularly seen in this system, including a super-outburst recurrence time of 36.8(4) days. We use the presence of the eclipse to place upper and lower limits on the inclination of the system and discuss the number of known eclipsing AM CVn systems versus what would be expected.
Corticosteroids for the treatment of hyperemesis gravidarum

Lynch L. , Bussel J . B. , McFarland J. G. , Chitkara U. & Berkowitz R. L. (1992) Antenatal treatment of alloimmune thrombocytopenia. Obstet Gynecol80, 67-71. Marzusch K. , Schnaidt M. , Diet1 J., Wiest E. , Hofstatter C. & Goelz E. (1992) High-dose immunoglobulin in the antenatal treatment of neonatal alloimmune thrombocytopenia: case report and review. Br J Obstet Gynaecol 99, 260-262. Mir N. et al. (1988) Failure of antenatal high-dose immunoglobulin to improve fetal platelet count in neonatal alloimmune thrombocytopenia. Vox Sang 55, 188189. Mueller-Eckhardt C. , Mueller-Eckhardt G. & Willen-OrfT H. (1985) Immunogenicity of and immune responses to the human platelet antigen Zw (a) is strongly associated with HLA-B8 and DR3. Tissue Antigens 26,71-76. Mueller-Eckhardt C. , Kiefel V. , Grubert A. et a/ . (1989) 384 cases of suspected neonatal alloimmune thrombocytopenia. Lancet i,
Do human cancers express shared protective antigens? or the necessity of remembrance of things past.

A majority of CTL-recognized antigens of human melanomas have turned out to be unmutated differentiation antigens expressed on melanomas and melanocytes alike. Additional, relatively cancer-specific antigens which are expressed on a significant proportion of melanomas, but not on most normal tissues, have also been shown to be recognized by CTLs. Finally, CTLs have been shown to detect mutated oncoproteins which are expressed in a wide spectrum of cancers but not in normal tissues. These observations have given rise to a view that human cancers share a number of antigens, which can form the basis for their immunotherapy. In contrast, cancer antigens of mice and rats (which are detected by tumor rejection assays in vivo, rather than CTLs generated in vitro) have been observed, generally, to be individually distinct, i.e. unique for each individual cancer. No convincing examples of shared cancer antigens exist in animal models of cancer. This dichotomy between the nature of cancer antigens of humans ('shared'), and of rodents ('unique') is addressed, and hopefully, resolved in this article.
Deletion of a GC-rich region flanking the enhancer element within the long terminal repeat sequences alters the disease specificity of Moloney murine leukemia virus

Moloney murine leukemia virus (M-MuLV) is a replication-competent retrovirus which induces T-lymphoblastic lymphoma 2 to 4 months after inoculation. Enhancer sequences in the U3 region of the M-MuLV long terminal repeat, primarily the 75-bp tandem repeats, strongly influence the disease specificity and latency of M-MuLV. We investigated the role of GC-rich sequences downstream of the tandem repeats in the disease specificity of M-MuLV. A recombinant M-MuLV lacking 23 bases of a GC-rich sequence (-174 to -151), Delta 27A M-MuLV, was tested for pathogenesis in neonatal NIH Swiss mice. Delta 27A M-MuLV induced disease with a longer latency than did M-MuLV (7 versus 3 months) in greater than 85% of inoculated mice. More interestingly, this virus showed an expanded repertoire of hematopoietic diseases. Molecular analyses and histopathologic examinations indicated that while 39% of mice inoculated with Delta 27A M-MuLV developed T-cell lymphoblastic lymphoma typical of wild-type M-MuLV, the majority developed acute myeloid leukemia, erythroleukemia, or B-cell lymphoma. Viral DNA corresponding to Delta 27A M-MuLV was detectable in most of the tumors analyzed. These findings indicate that the GC-rich region significantly influences the disease specificity and latency of M-MuLV.
Magnetoencephalography study of different relationships among low‐ and high‐frequency‐band neural activities during the induction of peaceful and fearful audiovisual modalities among males and females

Our previous study estimated the bias from the match attributes of the auditory and visual modalities related to a peaceful mood in the male brain. However, the interactions among the four main frequency bands of neural activity remain unknown. Therefore, this study uses magnetoencephalography to explore gender differences in the perceptions of auditory and visual modalities related to peaceful and fearful moods. Instead of analyzing single frequencies, this study analyzes interactions between low‐frequency phase and high‐frequency amplitude to reflect neural communication. The top four values in each of the 10 brain regions were averaged to give a representative value for further analysis with repeated‐measures ANOVA. The results from the cross‐frequency analyses suggest that delta–theta, delta–alpha, delta–beta, and delta–gamma couplings are associated with interactions between emotion and modality; theta–alpha, theta–beta, and theta–gamma couplings are associated with interactions between gender and emotion/time; alpha–beta and alpha–gamma couplings are associated with time; and beta–gamma coupling is associated with interactions between gender and modality. Although no obvious hemispheric lateralization of emotion in the macroscopic neural activity was found, these results reveal that males have stronger couplings (e.g., beta–gamma coupling) in the visual modality related to peaceful mood, whereas females have stronger couplings (e.g., beta–gamma coupling) in the audiovisual modality related to fearful mood. Gender differences become much more apparent when analysis is based on cross‐frequency coupling. © 2016 Wiley Periodicals, Inc.
Can Hospital Cultural Competency Reduce Disparities in Patient Experiences With Care?

Background:Cultural competency has been espoused as an organizational strategy to reduce health disparities in care. Objective:To examine the relationship between hospital cultural competency and inpatient experiences with care. Research Design:The first model predicted Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores from hospital random effects, plus fixed effects for hospital cultural competency, individual race/ethnicity/language, and case-mix variables. The second model tested if the association between a hospital’s cultural competency and HCAHPS scores differed for minority and non-Hispanic white patients. Subjects:The National CAHPS Benchmarking Database’s (NCBD) HCAHPS Surveys and the Cultural Competency Assessment Tool of Hospitals Surveys for California hospitals were merged, resulting in 66 hospitals and 19,583 HCAHPS respondents in 2006. Measures:Dependent variables include 10 HCAHPS measures: 6 composites (communication with doctors, communication with nurses, staff responsiveness, pain control, communication about medications, and discharge information), 2 individual items (cleanliness and quietness of patient rooms), and 2 global items (overall hospital rating, and whether patient would recommend hospital). Results:Hospitals with greater cultural competency have better HCAHPS scores for doctor communication, hospital rating, and hospital recommendation. Furthermore, HCAHPS scores for minorities were higher at hospitals with greater cultural competency on 4 other dimensions: nurse communication, staff responsiveness, quiet room, and pain control. Conclusions:Greater hospital cultural competency may improve overall patient experiences, but may particularly benefit minorities in their interactions with nurses and hospital staff. Such effort may not only serve longstanding goals of reducing racial/ethnic disparities in inpatient experience, but may also contribute to general quality improvement.
Spectroscopic and thermodynamic evidence for a complex denaturation mechanism of bovine β‐lactoglobulin A

We present a spectroscopic and calorimetric study on the thermal denaturation of bovine β‐lactoglobulin (β‐lg) variant A. Spectroscopic data allowed detection of a stable intermediate emerging from structural modifications restricted to local regions of the native molecule. It is suggested that this kind of intermediate could be a common property of lipocalins. Using the same set of parameters that has successfully related thermodynamics and structural properties of other proteins, it is shown that the thermally denatured state of β‐lg retains a significant amount of buried hydrophobic surface area. Thus, despite being a small protein composed of a single structural domain, β‐lg exhibits a complex unfolding mechanism, comprising at least two other species different from the native and completely unfolded states.
ConvNets with Smooth Adaptive Activation Functions for Regression

Within Neural Networks (NN), the parameters of Adaptive Activation Functions (AAF) control the shapes of activation functions. These parameters are trained along with other parameters in the NN. AAFs have improved performance of Convolutional Neural Networks (CNN) in multiple classification tasks. In this paper, we propose and apply AAFs on CNNs for regression tasks. We argue that applying AAFs in the regression (second-to-last) layer of a NN can significantly decrease the bias of the regression NN. However, using existing AAFs may lead to overfitting. To address this problem, we propose a Smooth Adaptive Activation Function (SAAF) with a piecewise polynomial form which can approximate any continuous function to arbitrary degree of error, while having a bounded Lipschitz constant for given bounded model parameters. As a result, NNs with SAAF can avoid overfitting by simply regularizing model parameters. We empirically evaluated CNNs with SAAFs and achieved state-of-the-art results on age and pose estimation datasets.
Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma

CXC chemokines modulate host immunity, neovascularization, growth and invasive behaviour of tumours. Despite their relevance in tumour biology, chemokine expression in intestinal‐ and diffuse‐type gastric carcinoma, which exhibit a completely different growth pattern, has not been investigated in detail. In this study, expression of the CXC chemokines CXCL8 [interleukin (IL)‐8], CXCL1 [growth‐related oncogene alpha (Groα)], CXCL9 [monokine induced by interferon (IFN)‐γ] and CXCL10 [IFN‐γ‐inducible protein‐10 (IP‐10)] and the corresponding chemokine receptors CXCR1–3 was investigated by immunohistochemistry in intestinal‐ and diffuse‐type gastric carcinoma. Tumour cells of all patients expressed CXCL8. CXCL8 expression was significantly stronger in tumour cells of diffuse‐ rather than intestinal‐type gastric carcinoma (P < 0·01) as determined by a semiquantitative score. CXCL1 was expressed almost exclusively by diffuse‐ but not intestinal‐type carcinoma cells. The corresponding chemokine receptors, CXCR1 and CXCR2, were found on carcinoma cells. Furthermore, CXCL8 expression correlated with number of tumour vessels (P < 0·01), suggesting an angiogenetic function in gastric carcinoma not only in vitro but also in vivo. CXCL10 and CXCL9, attractants for T cells, were expressed by peritumorous macrophages in close proximity to IFN‐γ‐producing CXCR3‐positive T cells in both tumour types. These chemokines may attract gastric carcinoma‐infiltrating T cells via an IFN‐γ‐mediated pathway and enhance host immunity against the tumour. In gastric carcinoma a complex interplay between CXC‐chemokine signals derived from both tumour cells and tumour‐infiltrating immune cells may exhibit pleiotropic effects in tumour biology that go far beyond their originally described functions as leucocyte chemoattractants. Because CXCL8 and CXCL1, which are known to increase growth and invasive behaviour of malignant tumours, are significantly stronger expressed in diffuse‐ than intestinal‐type gastric carcinoma, one may speculate that these chemokines influence the different growth pattern of gastric carcinoma types.
The Influence of Different Cultivating Conditions on Polymorphonuclear Leukocyte Apoptotic Process In Vitro, II: Ultrastructural Characteristics of PMN Populations Incubated with Proteinase 3 Anti-neutrophil Autoantibodies

The present study shows the effects of proteinase 3 anti-neutrophil cytoplasmic autoantibodies (PR3 ANCA) on polymorphonuclear leukocytes (PMN) apoptotic processes in vitro. The results are part of a generalized morphological analysis of 3 identical experiments on the influence of different cultivating conditions on the apoptotic processes. As controls, the authors use the results on spontaneous PMN apoptosis (Guejes L, Zurgil N, Deutsch M, Gilburd B, Shoenfeld Y. Ultrastruct Pathol. 2003;27:23–32) and PMN populations incubated with normal human IgG. Interaction of PR3 ANCA with the target antigen proteinase 3 (PR3) is one of the crucial pathogenic factors in Wegener granulomatosis (systemic autoimmune vasculitis). Following 40 min and 12 h incubation, PMN populations were evaluated by light microscopy, transmission electron microscopy, and immunogold electron microscopy. Twelve-hour cultures, either control or incubated with PR3 ANCA, contained different cell forms ranging from normal cells to cells at the final stages of apoptosis. Neutrophils at the state of complete manifestation of apoptotic phenotype were analyzed and compared. Three morphologically distinct apoptotic cell lines were characteristic for all PMN populations studied, regardless of cultivating conditions. As in spontaneous apoptosis, these cell lines are code-named “first,” “second,” and “third. ” The present study has shown, firstly, that in the presence of PR3 ANCA, all 3 apoptotic lines were modified or altered. Secondly, the modifications or alterations of apoptotic cell lines effected by PR3 ANCA are specific for each cell line: the “first” line is characterized by intensification and modification of activation; the “second” by vacuolized cell forms; and the “third” by pronounced lytic alterations of the nuclei, while the cytoplasm is fully identical to that of control cell lines.