Miracle-dz/UniFAR-FTUs huggingface dataset:
Histamine in Canned and Smoked Fishery Products Sold in Serbia

An increase in seafood-related illnesses as a consequence of an increase in seafood consumption has been documented recently. The United States Food and Drug Administration (FDA) has identified histamine as the major chemical hazard of seafood. The aim of this study was to determine histamine levels in 227 production lots (2043 subsamples) of canned tuna, canned sardines, canned mackerel and smoked salmon obtained from Serbian retail stores in 2018. Levels of histamine were determined using high performance liquid chromatography tandem mass-spectrometry. In addition, we compared histamine levels found in analysed products with levels established by the European Commission (EC) and FDA. Mean levels of histamine in compliant lots, according to EC Regulation 2073/2005, were 9.21, 3.16, 3.34 and 5.22 mg/kg in canned tuna, canned sardines, canned mackerel and smoked salmon, respectively. The highest histamine levels were found in canned tuna and canned mackerel, 1112 mg/kg and 412 mg/kg, respectively. Histamine was detected in 468 (22.91%) of all analysed subsamples. Levels above 100 mg/kg, which is the maximum histamine level allowed in canned fish in the EU, were found in 38 (1.86%) of analysed subsamples. According to EC Regulation 2073/2005, six (2.64%) of all analysed lots were found non-compliant, while 21 (9.25%) of analysed lots should be rejected according to the FDA limit (50 mg/kg).
Getting Pregnant after Infertility Management without Assisted Reproductive Technology in a Low-Income Setting

Getting pregnant after infertility management is a more challenging situation in some under equipped sub-Saharan setting. To highlight the determinants of conception without Assisted Reproductive technology (ART) in a low-income area. The current study concerned 2958 patients who sought care for infertility in the University Clinic of Kinshasa et the Centre Medical Edith, from January 2003 to December 2013. For them, any technique of ART was used. Age of patients ranged from 18 to 49 with average of 33.2 ± 5.6 years old. After treatment, 249 (9%) patients conceived (clinical pregnancy). Most of the patients who conceived were less than 36 years, without history of illegal abortions et who suffered from genital infections. The treatments closely associated with conception were antibiotics (73%), hydrotubation (12%) ovulation inductors (11%) and gynecologic surgery (4%). In that setting, ART is a must. Very few infertility problems, apart from infection and its consequences, can get solution.
Dwarfism: Medical and psychosocial aspects of profound short stature.

Read more and get great! That's what the book enPDFd dwarfism medical and psychosocial aspects of profound short stature will give for every reader to read this book. This is an on-line book provided in this website. Even this book becomes a choice of someone to read, many in the world also loves it so much. As what we talk, when you read more every page of this dwarfism medical and psychosocial aspects of profound short stature, what you will obtain is something great.
Intraspecific trait variability and community assembly in hawkmoths (Lepidoptera: Sphingidae) across an elevational gradient in the eastern Himalayas, India

Recent progress in functional ecology has advanced our understanding of the role of intraspecific (ITV) and interspecific (STV) trait variation in community assembly across environmental gradients. Studies on plant communities have generally found STV as the main driver of community trait variation, whereas ITV plays an important role in determining species co-existence and community assembly. However, similar studies of faunal taxa, especially invertebrates, are very few in number. We investigated variation of hawkmoth (Lepidoptera: Sphingidae) traits along an environmental gradient spanning 2600 m in the eastern Himalayas and its role in community assembly, using the morpho-functional traits of body mass (BM), wing loading (WL) and wing aspect ratio (AR). We employ the recently proposed T-statistics to test for non-random assembly of hawkmoth communities and the relative importance of the two opposing forces for trait divergence (internal filters) and convergence (external filters). Community-wide trait-overlap decreased for all three traits with increasing environmental distance, suggesting the presence of elevation specific optimum morphology (i.e. functional response traits). Community weighted mean of BM and AR increased with elevation. Overall, the variation was dominated by species turnover but ITV accounted for 25%, 23% and <1% variability of BM, WL and AR, respectively. T-statistics, which incorporates ITV, revealed that elevational communities had a non-random trait distribution, and that community assembly was dominated by internal filtering throughout the gradient. This study was carried out using easily measurable morpho-traits obtained from calibrated field images of a large number (3301) of individuals. That these also happened to be important environmental response traits resulted in a significant signal in the metrics that we investigated. Such studies of abundant and hyperdiverse invertebrate groups across large environmental gradients should considerably improve our understanding of community assembly processes.
The relationship between leg dominance and knee mechanics during the cutting maneuver

Females have shown a 3-9 times greater risk for anterior cruciate ligament (ACL) disruption compared to their male counterpart while participating in sports that involve high risk jumping or cutting maneuvers [4]. These ACL injuries are non-contact (NC) in nature and are shown to occur more frequently in field and court sports such as soccer, rugby and basketball [1, 2]. Soccer is known as a predominantly lower extremity sport, where athletes are required to run, cut and kick over a 90 minute period. During this time, an estimated 60-80% of all injuries occur at the ACL [2, 3]. Female soccer players have also shown close to a 70% greater chance of sustaining an ACL disruption to their support leg or nondominant limb (NDL) when compared to their kicking leg or dominant limb (DL) [2]. To date, few studies have looked into the role of limb dominance as a possible mechanism for NC ACL injuries in female soccer players.
Effects of extended intervention conditions on levels of physical activity exhibited by young children

By Ingunn Kristjansdottir Oveny University of the Pacific 2019 Physical activity is an important health-related behavior, and The Centers for Disease Control and Prevention (CDC) recommends that children engage in at least 60 minutes of moderate-to-vigorous-physical activity (MVPA) daily (CDC, 2015). However, worldwide, many children do not reach those requirements and health problems associated with physical inactivity are becoming more prevalent (CDC, 2015; World Health Organization [WHO], 2016). Recently, a few studies have conducted an intervention analysis to evaluate implications for function-based interventions to increase physical activity (Larson, Normand, Morley, & Miller, 2014; Zerger, Normand, Boga, & Patel, 2016). However, intervention analyses, indicate an overall decrease in levels of MVPA. This limitation could hinder further improvements of function-based interventions to increase physical activity, and is thus important to investigate. The current study partially replicated Zerger et al. (2016), and investigated the effects of alternating FA test conditions and repeated presentation of single condition exposure on maintenance of levels of MVPA in children. Additionally, the current study also evaluated the effectiveness of a more intermittent contingent schedules of reinforcement (i.e., fixed-interval limited-hold schedule) during intervention conditions. Results suggest it might be beneficial for caretakers and parents to deliver reinforcement in the form of social reinforcement to increase MVPA in preschool children. Additionally, the data suggest to promote MVPA, a more
A prospective study on the relevance of skin preparation for noise, impedance and ECG intervals among healthy males

Background and purpose: The relevance of skin preparationby abrasion preceded or not by alcohol cleansing for digitalECG (dECGs) variables was prospectively evaluated.Methods: In 22 healthy male subjects (40.2±9.7 years) dECGswere recorded continuously over 5 minute periods at 5 differenttime points at 3 separate 24-hour visits, employing 2 electrodetypes and no skin preparation, abrasion and alcohol cleansingbefore abrasion. Smoothed means dECG data covering 5minutes used for statistical analysis on leads V2-3 and V5.Results: Significant of skin preparation with reductions forskin-impedance and noise (pand with no further effect by alcohol cleansing (p>0.46). PRintervalswere significantly prolonged by skin preparation(p=0.0003 – p=0.0165) in leads V2-3 at 120 and 1 440 minutes;with additional impact of alcohol at 1 440 minutes (p=0.0005). Subject comfort was markedly higher with one of the electrodetypes (pConclusion: Skin preparation by abrasion should be employedprior to dECG recordings to improve signal properties.Cleansing with alcohol is generally not warranted. Skinirritation is dependant on choice of electrode.
How to Design Teaching Materials to Improve the Ability of Mathematical Reflective Thinking of Senior High School Students in Indonesia?

This research is a research and development which produces teaching materials. The research method consists of stages, namely: an introduction (literature study, observation, and interviews), product development of teaching materials, test by a team of experts, and restricted trial to the eleventh-grade students of senior high school in Cimahi, West Java, Indonesia. It was concluded that the teaching materials through scientific approach with what if not strategy load some activities including observing, trying, reasoning, asking, and concluding. The activities of asking using what if not strategy involve changing the data, adding the data, changing the data with the same question, and changing the question to the same data. In the teaching materials, it is presented some contextual problems in accordance with the experience of students. The design of teaching materials consists of three parts, namely: the beginning involves cover, preface, and table of contents; the content section: containing the title of the chapter dealing with the enumeration rules as a representation of the contents of the chapter; and closing: as a reflection and evaluation of the material presented on teaching materials for the next revision. Teaching materials can enhance the ability of reflective thinking of the students with medium criteria.
Genomic analyses reveal selection footprints in rice landraces grown under on‐farm conservation conditions during a short‐term period of domestication

Traditional rice landraces grown under on‐farm conservation conditions by indigenous farmers are extremely important for future crop improvement. However, little is known about how the natural selection and agriculture practices of indigenous farmers interact to shape and change the population genetics of rice landraces grown under on‐farm conservation conditions during the domestication. In this study, we sequenced DNA from 108 core on‐farm conserved rice landraces collected from the ethnic minority regions of Yunnan, China, including 56 accessions collected in 1980 and 52 accessions collected in 2007 and obtained 2,771,245 of credible SNPs. Our findings show that most genetic diversity was retained during the 27 years of domestication by on‐farm conservation. However, SNPs with marked allele frequency differences were found in some genome regions, particularly enriched in genic regions, indicating changes in genic regions may have played a much more prominent role in the short‐term domestication of 27 years. We identified 186 and 183 potential selective‐sweep regions in the indica and japonica genomes, respectively. We propose that on‐farm conserved rice landraces during the short‐term domestication had a highly polygenic basis with many loci responding to selection rather than a few loci with critical changes in response to selection. Moreover, loci affecting important agronomic traits and biotic or abiotic stress responses have been particularly targeted in selection. A genome‐wide association study identified 90 significant signals for six traits, 13 of which were in regions of selective sweeps. Moreover, we observed a number of significant and interesting associations between loci and environmental factors, which implies adaptation to local environment. Our results provide insights into short‐term evolutionary processes and shed light on the underlying mechanisms of on‐farm conservation.
TECHNICAL EFFICIENCY ASSESSMENT OF MATERNAL HEALTH SERVICES IN NEGERI SEMBILAN, MALAYSIA USING DATA ENVELOPMENT ANALYSIS

Introduction : Primary care is the first level of contact with the health system to promote health, prevent illness, care for common illnesses, and manage on-going health problems. Maternal health services were one of the important components of primary care delivered through health clinics and community clinics. It is crucial to ensure scarce resources in health clinic were utilized efficiently. Data envelop analysis is a technique which had advantage in assessment of efficiency of primary care because the technique can handle multiple inputs and outputs in efficiency score calculation. Objectives: To assess technical efficiency of maternal health services and it determinants in primary care setting of health clinics in Negeri Sembilan using data envelopment analysis (DEA). Methodology: This e valuation research employing cross-sectional study design using primary data from health district offices and health clinics in Negeri Sembilan. Sources of data includes administrative records and expenditure records from district health offices, and maternal health services utilization obtained from clinic records. The study randomly selected 16 maternal health services of health clinics as DMUs. Data for 2016 and 2017 were used in the analysis. Analysis of DEA used two-stage DEA. In the first stage DEA to efficiency score, namely: overall technical efficiency (OTE), pure technical efficiency (PTE) and scale efficiency (SE) scores. In the second stage, four environmental variables namely location of health clinic, distance of health clinic to the nearest health facility, years of service of nurses and comorbidity of patient regressed against PTE score using Tobit regression analysis. Results: In 2016, average pure technical efficiency (PTE) for maternal health services were 60.50% (SD 35.50). An increased in mean PTE in 2017 for maternal health services with the score of 67.30% (SD 34.30). Maternal health services in type 2 health clinic were efficient as compared with other types of health clinic in 2016. In 2017, maternal health services in health clinic type 6 were efficient. One determinant was found to significantly affect TE (comorbidity of patient). Conclusion: The findings from this study found that technical efficient maternal health services in Negeri Sembilan were in Health Clinic Type 5 (31.25%) and Health Clinic Type 6 (37.50%) in 2016 and 2017 respectively. Patients with more comorbidity significantly decrease technical efficiency of maternal health services. Keywords : technical efficiency, maternal health, primary care service, health clinic, data envelopment analysis.
Risk assessment of FLT3 and PAX5 variants in B-acute lymphoblastic leukemia: a case–control study in a Pakistani cohort

AIMS B-cell acute lymphoblastic leukemia (B-ALL) is amongst the most prevalent cancers of children in Pakistan. Genetic variations in FLT3 are associated with auto-phosphorylation of kinase domain that leads to increased proliferation of blast cells. Paired box family of transcription factor (PAX5) plays a critical role in commitment and differentiation of B-cells. Variations in PAX5 are associated with the risk of B-ALL. We aimed to analyze the association of FLT3 and PAX5 polymorphisms with B cell leukemia in Pakistani cohort. METHODS We collected 155 B-ALL subject and 155 control blood samples. For analysis, genotyping was done by tetra ARMS-PCR. SPSS was used to check the association of demographic factors of SNPs present in the population with the risk of B-ALL. RESULTS Risk allele frequency A at locus 13q12.2 (rs35958982, FLT3) was conspicuous and showed positive association (OR = 2.30, CI [1.20–4.50], P = 0.005) but genotype frequency (OR = 3.67, CI [0.75–18.10], P = 0.088) failed to show any association with the disease. At locus 9p13.2 (rs3780135, PAX5), the risk allele frequency was significantly higher in B-ALL subjects than ancestral allele frequency (OR = 2.17, CI [1.37–3.43], P = 0.000). Genotype frequency analysis of rs3780135 polymorphism exhibited the protective effect (OR = 0.55, CI [0.72–1.83], P = 0.029). At locus 13q12.2 (rs12430881, FLT3), the minor allele frequency G (OR = 1.15, CI [1.37–3.43], P = 0.043) and genotype frequency (OR = 2.52, P = 0.006) reached significance as showed p < 0.05. CONCLUSION In the present study, a strong risk of B-cell acute lymphoblastic leukemia was associated with rs35958982 and rs12430881 polymorphisms. However, rs3780135 polymorphism showed the protective effect. Additionally, other demographic factors like family history, smoking and consanguinity were also found to be important in risk assessment. We anticipate that the information from genetic variations in this study can aid in therapeutic approach in the future.
Gradients in the cerebellar cortex enable Fourier-like transformation and improve storing capacity

Cerebellar granule cells (GCs) making up majority of all the neurons in the vertebrate brain, but heterogeneities among GCs and potential functional consequences are poorly understood. Here, we identified unexpected gradients in the biophysical properties of GCs. GCs closer to the white matter (inner-zone GCs) had higher firing thresholds and could sustain firing with larger current inputs. Dynamic clamp experiments showed that inner- and outer-zone GCs preferentially respond to high- and low-frequency mossy fiber inputs, respectively, enabling to disperse the mossy fiber input into its frequency components as performed by a Fourier transformation. Furthermore, inner-zone GCs have faster axonal conduction velocity and elicit faster synaptic potentials in Purkinje cells. Neuronal network modeling revealed that these gradients improve spike-timing precision of Purkinje cells and decrease the number of GCs required to learn spike-sequences. Thus, our study uncovers biophysical gradients in the cerebellar cortex enabling a Fourier-like transformation of mossy fiber inputs.
PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3K/Akt/mTOR signaling pathway

The present study aimed to explore the role of the PTEN/Akt/mTOR signaling pathway in the neurite outgrowth and apoptosis of cortical neurons. Cortical neurons were seeded on or adjacent to chondroitin sulfate proteoglycans. The length, number and crossing behavior of the neurites were calculated. Immunohistochemical staining and TUNEL data were analyzed. Neurites treated with PTEN inhibitor exhibited significant enhancements in elongation, initiation and crossing abilities when they encountered chondroitin sulfate proteoglycans in vitro. These effects disappeared when the PTEN/Akt/mTOR signaling pathway was blocked. Neurons exhibited significant enhancements in survival ability following PTEN inhibition. The present study demonstrated that PTEN inhibition can promote axonal elongation and initiation in cerebral cortical neurons, as well as the ability to cross the chondroitin sulfate proteoglycan border. In addition, PTEN inhibition is useful for protecting the neuron from apoptosis. The PTEN/Akt/mTOR signaling pathway is an important signaling pathway.
Firm-Specific Attributes and the Value Relevance of Accounting Information in Nigeria

This paper examines how firm-specific attributes affect the value relevance of summary accounting numbers in Nigeria. The paper also investigates whether the adoption of International Financial Reporting Standards (IFRS) affects the relationship between the summary accounting numbers (book value of equity and earnings) and firm-specific characteristics (firm size, liquidity and leverage). Data from 54 firms in 10 sectors of the Nigerian Stock Exchange (covering a period of 6 years, 2009 to 2014, divided into 3 years pre-IFRS period and 3 years IFRS period) were analyzed based on the Ohlson (1995) model. Results from the analyses indicate that firm-specific characteristics affect the relationship between summary accounting numbers and market value, and this effect increased in the period after IFRS adoption. The implication of these findings is that firms seeking to improve their market values must work towards the firm-specific attributes that enhance firm value. By examining the effect of firm-specific attributes on the value relevance of accounting information using data from the Nigerian Stock Exchange, before and after IFRS adoption, this study fills a research gap.
Cell-wall synthases contribute to bacterial cell-envelope integrity by actively repairing defects

Cell shape and cell-envelope integrity of bacteria are determined by the peptidoglycan cell wall. In rod-shaped Escherichia coli, two conserved sets of machinery are essential for cell-wall insertion in the cylindrical part of the cell, the Rod complex and the class-A penicillin-binding proteins (aPBPs). While the Rod complex governs rod-like cell shape, aPBP function is less well understood. aPBPs were previously hypothesized to either work in concert with the Rod complex or to independently repair cell-wall defects. First, we demonstrate through modulation of enzyme levels that class-A PBPs do not contribute to rod-like cell shape but are required for mechanical stability, supporting their independent activity. By combining measurements of cell-wall stiffness, cell-wall insertion, and PBP1b motion at the single-molecule level we then demonstrate that PBP1b, the major class-A PBP, contributes to cell-wall integrity by localizing and inserting peptidoglycan in direct response to local cell-wall defects.