Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term programing of psychopathology-like behaviors in male rats by peripubertal stress depends on individual’s glucocorticoid responsiveness to stress

Abstract Experience of adversity early in life and dysregulation of hypothalamus–pituitary–adrenocortical (HPA) axis activity are risk factors often independently associated with the development of psychopathological disorders, including depression, PTSD and pathological aggression. Additional evidence suggests that in combination these factors may interact to shape the development and expression of psychopathology differentially, though little is known about underlying mechanisms. Here, we studied the long-term consequences of early life stress exposure on individuals with differential constitutive glucocorticoid responsiveness to repeated stressor exposure, assessing both socio-affective behaviors and brain activity in regions sensitive to pathological alterations following stress. Two rat lines, genetically selected for either low or high glucocorticoid responsiveness to repeated stress were exposed to a series of unpredictable, fear-inducing stressors on intermittent days during the peripuberty period. Results obtained at adulthood indicated that having high glucocorticoid responses to repeated stress and having experience of peripuberty stress independently enhanced levels of psychopathology-like behaviors, as well as increasing basal activity in several prefrontal and limbic brain regions in a manner associated with enhanced behavioral inhibition. Interestingly, peripuberty stress had a differential impact on aggression in the two rat lines, enhancing aggression in the low-responsive line but not in the already high-aggressive, high-responsive rats. Taken together, these findings indicate that aberrant HPA axis activity around puberty, a key period in the development of social repertoire in both rats and humans, may alter behavior such that it becomes anti-social in nature.
Dendroclimatological potential of the Australian red cedar.

We examined Toona ciliata M.Roemer (Australian red cedar) for its potential to deliver annually resolved tree-ring proxy data. Such proxies are valuable and sought-after sources for reconstructing climate beyond instrumental records, especially in Australia. T. ciliata was chosen because it is one of the few deciduous tree species in Australia experiencing a seasonally dormant period of the cambium. This was confirmed by a preliminary tree-ring analysis which revealed distinct growth rings. Because of initial uncertainties regarding reliable annual growth rings in the wood of T. ciliata, a dendrometer-band study was conducted in addition to the tree-ring analysis. Stem increments revealed a common period of dormancy during winter and the measurements were found to correlate with both precipitation and temperature, depending on the site. For the first time, our tree-ring analysis demonstrated that samples from different individuals can be cross-dated and the resulting site index from Upper Kangaroo Valley (New South Wales) has the potential to reconstruct early season temperatures and late-season rainfall.
‘Role of sentinel lymph node biopsy as a staging procedure in patients with melanoma: A critical appraisal’ by Omgo E Nieweg, Alan Cooper and John F Thompson

Michael Sladden,* Samuel Zagarella,* Catalin Popescu* and Michael Bigby* Department of Medicine, University of Tasmania, Launceston, Tasmania, Department of Dermatology, University of Sydney Medical School, Sydney, New South Wales, Australia, Department of Dermatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, and Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Ranging Behavior, Group Size and Behavioral Flexibility in Ethiopian Hamadryas Baboons (Papio hamadryas hamadryas)

This study reports group size, home range size, daily path lengths, seasonal effects on ranging behavior and qualitative information on diet for a population of hamadryas baboons inhabiting the lowlands of the northern Rift Valley in central Ethiopia. The minimum home range size and daily path length for this population are similar to those reported for other populations of hamadryas baboons in Ethiopia and Saudi Arabia. Group sizes, however, are much larger than those in most other hamadryas populations for which published data are available. The large group sizes in this area may be related to the abundance of one food resource in particular, doum palm nuts. Overall, this study suggests that hamadryas baboons may be more flexible in some aspects of their behavioral ecology (e.g. group size) than in others (e.g. ranging behavior).
Design of Planar High-Gain Antenna Using SIW Cavity Hybrid Mode

In this communication, a planar high-gain slot antenna backed by a rectangular substrate-integrated waveguide (SIW) cavity is presented. The proposed antenna uses a narrow rectangular SIW cavity with high length-to-width ratio. This modifies the conventional sinusoidal field distribution of the cavity modes to generate a hybrid mode field distribution with more field concentration at the center of the cavity. A closed form expression is presented which represents the proposed hybrid mode field distribution as a summation of multiple TEym10 cavity modes. A slot antenna placed at the top plate of the proposed cavity is excited by the hybrid mode. Calculation of far-field radiation pattern of the proposed antenna is presented, which exhibits its potential to produce narrower main beam along with high gain. To validate the concept, a prototype is fabricated in a thin substrate ( ${h} =0.787\,\,\text {mm}$ ). The experimental result shows antenna resonance at 9.5 GHz with high gain of 9.62 dBi.
The influence of anesthetic agents on rat hepatic cytochromes P450 in vivo.

The objective of this study was to identify which anesthetics when used acutely will affect cytochrome P450 (CYP) activity in male Sprague-Dawley rats in vivo. The anesthetics tested were fentanyl citrate, alpha-chloralose, ketamine, urethane (ethyl carbamate), halothane, and ether. CO2 anesthesia was used as the control comparator. Theophylline was used as a probe for CYP1A activity, phenobarbital for CYP2B/2C, flecainide for CYP2D1, and ethosuximide for CYP3A activity. All probes were administered via tail vein injection after anesthetic-induced loss of the righting reflex. Single sample probe clearances were estimated, and used as an index of CYP activity. Fentanyl citrate, alpha-chloralose, halothane, and ether did not have statistically significant effects on any of the CYP activities. Ketamine did not significantly affect CYP1 or CYP2B/2C activity. However, it decreased the clearance of flecainide (i.e. CYP2D1 activity) by 13.4% (p < 0.001) and the clearance of ethosuximide (i.e. CYP3A activity) by 17.6% (p < 0.0001). Urethane increased the clearance of theophylline by 91.5% (p < 0.0001), and decreased the clearance of ethosuximide by 40.5% (p < 0.0001) though it did not affect CYP2B/2C or CYP2D1 activities significantly. From this data, we conclude that a single dose of ketamine mildly inhibits the activity of CYP2D1 and CYP3A, and a single dose of urethane strongly inhibits CYP3A but increases CYP1A activity.
Modeling Progression Free Survival in Breast Cancer with Tensorized Recurrent Neural Networks and Accelerated Failure Time Models

In this work we attempt to predict the progression-free survival time of metastatic breast cancer patients by combining state-of-the-art deep learning approaches with traditional survival analysis models. In order to tackle the challenge of sequential clinical records being both high-dimensional and sparse, we propose to apply a tensorized recurrent neural network architecture to extract a latent representation from the entire patient history. We use this as the input to an Accelerated Failure Time model that predicts the survival time. Our experiments, conducted on a large real-world clinical dataset, demonstrate that the tensorized recurrent neural network largely reduces the number of weight parameters and the training time. It also achieves modest improvements in prediction, in comparison with state-of-the-art recurrent neural network models enhanced with event embeddings.
Developing Predictive Equations to Model the Visual Demand of In-Vehicle Touchscreen HMIs

ABSTRACT Touchscreen human–machine interfaces (HMIs) are commonly employed as the primary control interface and touch-point of vehicles. However, there has been very little theoretical work to model the demand associated with such devices in the automotive domain. Instead, touchscreen HMIs intended for deployment within vehicles tend to undergo time-consuming and expensive empirical testing and user trials, typically requiring fully functioning prototypes, test rigs, and extensive experimental protocols. While such testing is invaluable and must remain within the normal design/development cycle, there are clear benefits, both fiscal and practical, to the theoretical modeling of human performance. We describe the development of a preliminary model of human performance that makes a priori predictions of the visual demand (total glance time, number of glances, and mean glance duration) elicited by in-vehicle touchscreen HMI designs, when used concurrently with driving. The model incorporates information theoretic components based on Hick–Hyman Law decision/search time and Fitts’ Law pointing time and considers anticipation afforded by structuring and repeated exposure to an interface. Encouraging validation results, obtained by applying the model to a real-world prototype touchscreen HMI, suggest that it may provide an effective design and evaluation tool, capable of making valuable predictions regarding the limits of visual demand/performance associated with in-vehicle HMIs, much earlier in the design cycle than traditional design evaluation techniques. Further validation work is required to explore the behavior associated with more complex tasks requiring multiple screen interactions, as well as other HMI design elements and interaction techniques. Results are discussed in the context of facilitating the design of in-vehicle touchscreen HMI to minimize visual demand.
How older adults use cognition in sentence-final word recognition

ABSTRACT This study examined the effects of executive control and working memory on older adults’ sentence-final word recognition. The question we addressed was the importance of executive functions to this process and how it is modulated by the predictability of the speech material. To this end, we tested 173 neurologically intact adult native English speakers aged 55–84 years. Participants were given a sentence-final word recognition test in which sentential context was manipulated and sentences were presented in different levels of babble, and multiple tests of executive functioning assessing inhibition, shifting, and efficient access to long-term memory, as well as working memory. Using a generalized linear mixed model, we found that better inhibition was associated with higher accuracy in word recognition, while increased age and greater hearing loss were associated with poorer performance. Findings are discussed in the framework of semantic control and are interpreted as supporting a theoretical view of executive control which emphasizes functional diversity among executive components.
Statural growth and prevalence of endocrinopathies in relation to liver iron content (LIC) in adult patients with beta thalassemia major (BTM) and sickle cell disease (SCD)

Despite regular blood transfusion and iron chelation therapy, growth impairment and pubertal delay are commonly seen in children and adolescents with transfusion-dependent Beta thalassaemia major (BTM) and sickle cell disease (SCD). We evaluated growth parameters and endocrine disorders in relation to the liver iron concentration (LIC) assessed by the Ferriscan® method in a cohort of adults with SCD (n=40) and BTM (n=52) receiving blood transfusions and iron chelation therapy since early childhood. Before transfusion, hemoglobin concentration had not been less than 9 g/dl in the past 12 years; subcutaneous daily desferrioxamine was administered for all of them since early childhood (2-5 years of age). All patients were shifted to oral therapy with deferasirox iron chelation, 20 mg/daily for the past 5 years. BTM patients with higher LIC (>15 mg Fe/g dry weight) had significantly shorter stature, lower insulin-like growth factor-I SDS (IGF-I SDS), higher alanine transferase (ALT) and serum ferritin concentrations compared to thalassemic patients with lower LIC. Patients with SCD with LIC >8 mg Fe/g dry weight had significantly shorter stature, lower IGF-I SDS and higher ALT compared to SCD patients with lower LIC. Patients with BTM had significantly shorted final height (Ht-SDS), IGF-I SDS and FT4 level compared to patients with SCD. LIC and mean fasting blood glucose (FBG) were significantly higher in patients with BTM compared to those with SCD. The linear regression analysis showed a significant correlation between LIC and serum ferritin level in SCD and BTM. LIC and serum ferritin level were also correlated significantly with IGF-I level in patients with BTM. LIC was correlated significantly with ALT in patients with BTM. In conclusion, the prevalence of endocrinopathies especially hypothyroidism, DM, and hypogonadism were significantly higher in BTM patients versus SCD patients and higher in patients with higher LIC versus those with lower LIC. These complications occurred less frequently, but still considerable, in chronically transfused patients with SCD. (www.actabiomedica.it)
How I manage peripheral T‐cell lymphoma, not otherwise specified and angioimmunoblastic T‐cell lymphoma: current practice and a glimpse into the future

Peripheral T‐cell lymphoma (PTCL), not otherwise specified (NOS) and angioimmunoblastic T‐cell lymphoma (AITL) are the most frequent of more than 20 mature PTCL entities featuring a broad spectrum of morphological, immunophenotypic, molecular and clinical characteristics. Unfortunately, recent progress in understanding the (epi)genetic background of PTCL has not been met with similar advances in treatment. Thus, CHO(E)P [cyclophosphamide, doxorubicin, vincristine, and prednisone (plus etoposide)] remains standard first‐line therapy. Patients without comorbidities achieving complete or partial remission proceed to autologous stem cell transplantation. With this approach about 50% of patients survive long‐term. Patients relapsing after or progressing during first‐line therapy have a dismal prognosis. They receive salvage gemcitabine‐therapy followed by allogeneic transplantation whenever possible. After allografting, approximately half of the patients survive long‐term; any other treatment is palliative. New drugs investigated in phase II studies achieved response rates between 10% and 30%; long‐term remissions are the exception to the rule. While most new drugs are not licensed and not readily available, a plethora of other innovative drugs targeting (epi‐)genetic abnormalities are in early development. These, together with combinations of new and old drugs, will hopefully increase response to first‐line therapy, bridge more patients to transplantation, and finally improve prognosis for all patients with PTCL.
Phase I trial of anti-GD2 monoclonal antibody hu3F8 plus GM-CSF: Impact of body weight, immunogenicity and anti-GD2 response on pharmacokinetics and survival

ABSTRACT Fifty-seven stage 4 patients with refractory/relapsed neuroblastoma were enrolled in a phase I trial (Clinicaltrials.gov NCT01757626) using humanized anti-GD2 monoclonal antibody hu3F8 in combination with granulocyte-macrophage colony-stimulating factor. The influence of body weight and human anti-human antibody (HAHA) on the pharmacokinetics (PK) of hu3F8, and the effect of de novo anti-GD2 response on patient outcome were explored. Serum samples before hu3F8 infusion, and serially up to day 12 during treatment cycle #1, and at 5 min after each hu3F8 infusion for all subsequent cycles were collected. PK was analyzed using non-compartmental modeling. Immunogenicity was assayed by HAHA response, and vaccination effect by induced host anti-GD2 response measured periodically until disease progression or last followup. Progression-free and overall survival was estimated by the Kaplan-Meier method. Despite dosing being based on body weight, smaller patients had consistently lower area-under-the-curve and faster clearance over the 15 dose levels (0.9 to 9.6 mg/kg per treatment cycle) in this trial. Positive HAHA, defined by the upper limit of normal, when measured within 10 days from the last hu3F8 dose received, was associated with significantly lower serum hu3F8. Despite prior sensitization to other anti-GD2 antibody, e.g. mouse 3F8 or ch14.18, 75% of the patients never developed HAHA response even after getting more treatment cycles. Hu3F8 induced a de novo anti-GD2 response in patients, which was prognostic of progression-free survival. We conclude that hu3F8 had low immunogenicity. During treatment, positive HAHA and low body weight affected PK adversely, whereas induced anti-GD2 response was an outcome predictor.
Genetic variability among Hymenolepis nana isolates from different geographical regions in China revealed by sequence analysis of three mitochondrial genes

Abstract Hymenolepis nana is a common tapeworm that parasitizes in the small intestine of rodent animals and humans. The present study examined the sequence diversity of three mitochondrial (mt) genes namely NADH dehydrogenase subunits 5 (nad5), small subunit ribosomal RNA (rrnS), and ATPase subunit 6 (atp6) of H. nana from mice in different geographical regions of China. A part of the nad5 (pnad5), complete rrnS and atp6 genes were amplified separately from individual H. nana isolates using polymerase chain reaction (PCR) and then sequenced. The sequences of pnad5, rrnS, and atp6 were 710 bp, 704–711 bp, and 516 bp in length, respectively. The A + T contents of the sequences were 70.1–73.5% (pnad5), 70.1–71.7% (rrnS), and 76.6–77.9% (atp6). Sequence variation within H. nana was 0–1.4% for atp6, 0–1.7% for rrnS, and 0–0.7% for pnad5. The inter-specific sequence differences between H. nana and Hymenolepis diminuta were significantly higher, which was 31.6–31.7% (pnad5), 16.1–17.6% (rrnS), and 26.5–27.1% (atp6). Phylogenetic analysis based on the combined three sequences using the maximum parsimony (MP) method supported that H. nana is a species complex or “cryptic” species. These findings demonstrated clearly the usefulness of the three mtDNA sequences for population genetics and systematic studies of H. nana of human and animal health significance.
Pneumomediastinum and Pneumothorax Associated with Herpes Simplex Virus (HSV) Pneumonia

Patient: Male, 37 Final Diagnosis: HSV pneumonia Symptoms: Cough • fever • sob Medication: — Clinical Procedure: — Specialty: Infectious Diseases Objective: Unusual clinical course Background: Pneumonia is one of the most common causes of death from infectious disease in the United States (US). Although most cases of community-acquired pneumonia (CAP) are secondary to bacterial infection, up to one-third of cases are secondary to viral infection, most commonly due to rhinovirus and influenza virus. Pneumonia due to herpes simplex virus (HSV) is rare, and there is limited knowledge of the pathogenesis and clinical complications. This report is of a fatal case of HSV pneumonia associated with bilateral pneumothorax and pneumomediastinum. Case Report: A 36-year-old homeless male Hispanic patient, who was a chronic smoker, with a history of intravenous drug abuse and a medical history of chronic hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection, not on highly active antiretroviral therapy (HAART), was admitted to hospital as an emergency with a seven-day history of productive purulent cough. The patient was admitted to the medical intensive care unit (MICU) with a diagnosis of CAP, with intubation and mechanical ventilation. Broncho-alveolar lavage (BAL) was performed and was positive for HSV. The patient developed bilateral pneumothorax with pneumomediastinum, which was fatal, despite aggressive clinical management. Conclusions: Pneumonia due to HSV infection is uncommon but has a high mortality. Although HSV pneumonia has been described in immunocompromised patients, further studies are required to determine the pathogenesis, early detection, identification of patients who are at risk and to determine the most effective approaches to prophylaxis and treatment for HSV pneumonia.
False alarm? A comprehensive reanalysis of "Evidence that psychopathology symptom networks have limited re...

Citation for published version (APA): Borsboom, D. , Fried, E. I. , Epskamp, S. , Waldorp, L. J., van Borkulo, C. D. , van der Maas, H. L. J., & Cramer, A. O. J. (2017). False alarm? A comprehensive reanalysis of "evidence that psychopathology symptom networks have limited replicability" by Forbes, Wright, Markon, and Krueger (2017). Journal of Abnormal Psychology, 126(7), 989-999. https://doi.org/10.1037/abn0000306
The JCMT Gould Belt Survey: A First Look at the Auriga–California Molecular Cloud with SCUBA-2

We present 850 and 450 μm observations of the dense regions within the Auriga–California molecular cloud using SCUBA-2 as part of the JCMT Gould Belt Legacy Survey to identify candidate protostellar objects, measure the masses of their circumstellar material (disk and envelope), and compare the star formation to that in the Orion A molecular cloud. We identify 59 candidate protostars based on the presence of compact submillimeter emission, complementing these observations with existing Herschel/SPIRE maps. Of our candidate protostars, 24 are associated with young stellar objects (YSOs) in the Spitzer and Herschel/PACS catalogs of 166 and 60 YSOs, respectively (177 unique), confirming their protostellar nature. The remaining 35 candidate protostars are in regions, particularly around LkHα 101, where the background cloud emission is too bright to verify or rule out the presence of the compact 70 μm emission that is expected for a protostellar source. We keep these candidate protostars in our sample but note that they may indeed be prestellar in nature. Our observations are sensitive to the high end of the mass distribution in Auriga–Cal. We find that the disparity between the richness of infrared star-forming objects in Orion A and the sparsity in Auriga–Cal extends to the submillimeter, suggesting that the relative star formation rates have not varied over the Class II lifetime and that Auriga–Cal will maintain a lower star formation efficiency.
Title Integration of genomic and epigenomic features to predictmeiotic recombination hotspots in human and mouse

The regulatory mechanism of meiotic recombination hotspots is a fundamental problem in biology, with broad impacts on areas ranging from disease study to evolution. Recently, many genomic and epigenomic features have been associated with recombination hotspots, but none of them can explain hotspots consistently. It is highly desirable to integrate the different features into a predictive model, and study the relation of the features with hotspots and themselves with a systems approach. Moreover, due to rapid and dynamic evolution of recombination hotspots, regulatory mechanisms of hotspots that are evolutionarily conserved among species remain unclear. We propose a machine learning approach that encodes genomic and epigenomic features into a support vector machine (SVM). Trained on known hotspots and coldspots in human and mouse genomes, the model is able to predict hotspots based on the features with good performance in both species. Moreover, the model reports a ranking of feature importance, uncovering the interactions of the features with hotspots and among themselves. Applying the method to large-scale data, we identified evolutionarily conserved patterns of trans-regulators and feature importance between human and mouse hotspots. This is the first attempt to build a predictive model to identify evolutionarily conserved mechanisms for recombination hotspots by integrating both genomic and epigenomic features.