Miracle-dz/UniFAR-FTUs huggingface dataset:
PPA_A_209212 1477..1486

Ahmed Saleh Kenawy Osama Gheith Torky Al-Otaibi Nashwa Othman Hasaneen Abo Atya Mohamed Al-Otaibi Mohamed Sobhy Nagy 1Hamed Al-Essa Organ Transplant Center, Ibn Sina Group of Hospitals, Ministry of Health, Kuwait City, Kuwait; 2Dasman Diabetes Institute, Ministry of Health, Kuwait City, Kuwait; 3Kuwait Cancer Center, Ministry of Health, Kuwait City, Kuwait Introduction and aim: Kidney transplantation is the optimal treatment choice for end stage renal disease; this option needs a major change in the recipients’ lifestyle and requires strict adherence to medications. The study aim was to assess the compliance of renal transplant patients to medications and lifestyle modifications in the Hamed Al-Essa Organ Transplant Center in Kuwait. Patients and methods: One-hundred and twenty renal transplant patients were interviewed for their lifestyle behaviors after transplantation, including transplant adherence to their medications, healthy meals, personal hygiene, physical activity, regular out-patient follow up visits, and preventive measures against infection and cancer, in addition to sexual function. The questionnaire used was created by staff of the Faculty of Medicine, Mansura University, Egypt. Results: Sixty percent of the renal transplant patients were compliant with medications and lifestyle. Risk factors associated with poor medication compliance were being Kuwaiti citizens, women, and having had unrelated living donors (p<0.05). Compliance with medications was associated with less transplant related complications (p=0.003). Only 15% of the participants were compliant with low-salt diet, 8% with low-fat, and 11% with low-carb. One fourth of patients were compliant with a daily shower and 20% were physically active. More than 70% of the patients were regularly visiting the out-patient clinic. Compliance to preventive measures against infection was observed in 85% of patients but only 5% were avoiding direct sun exposure. Half of the male patients had sexual dysfunction but only half of them were consulting their nephrologists about it. Conclusion: Kidney transplant patients in Kuwait had moderate compliance with medications and lifestyle modifications. Closer assessment is needed to identify the risk factors before and after transplantation to avoid any complications associated with non-compliance.
The Apolipoprotein e 4 Allele Determines Prognosis and the Effect on Prognosis of Simvastatin in Survivors of Myocardial Infarction

Background—Carriers of thee4 allele of the apolipoprotein E gene are at a higher risk of coronary heart disease than individuals with other genotypes. We examined whether the risk of death or a major coronary event in survivors of myocardial infarction depended on apolipoprotein E genotype and whether the benefits of treatment with simvastatin differed between genotypes. Methods and Results—Cox proportional hazards models were used to analyze 5.5 years of follow-up data from 966 Danish and Finnish myocardial infarction survivors enrolled in the Scandinavian Simvastatin Survival Study. A total of 16% of the 166 e4 carriers in the placebo group died compared with 9% of the 312 patients without the allele, which corresponds to a mortality risk ratio of 1.8 (95% confidence interval, 1.1 to 3.1). The risk ratio was unaffected by considerations of sex, age, concurrent angina, diabetes, smoking, and serum lipids in multivariate analyses. Simvastatin treatment reduced the mortality risk to 0.33 (95% confidence interval, 0.16 to 0.69) in e4 carriers and to 0.66 (95% confidence interval, 0.35 to 1.24) in other patients (P50.23 for treatment by genotype interaction). Apolipoprotein E genotype did not predict the risk of a major coronary event. Baseline serum levels of lipoprotein(a) also predicted mortality risk and could be combined with e4-carrier status to define 3 groups of patients with different prognoses and benefits from treatment. Conclusions—Myocardial infarction survivors with the e4 allele have a nearly 2-fold increased risk of dying compared with other patients, and the excess mortality can be abolished by treatment with simvastatin. (Circulation. 2000;101:1366-1371.)
Concepções dos pediatras acerca da educação e do desenvolvimento infantil

Na Andaluzia (Espanha), os pediatras sao a principal fonte tecnica de aconselhamento sobre o desenvolvimento e a educacao infantil. No entanto existe um conhecimento limitado sobre as suas ideias, praticas e habilidades para orientar os pais. Neste estudo, atraves da analise de conteudo das entrevistas realizadas a vinte e seis pediatras, descrevem-se os objectivos da agenda pediatrica, as percepcoes sobre as praticas parentais e as mensagens educativas transmitidas aos pais. Os resultados mostram que a agenda pediatrica e centrada sobretudo nos temas biomedicos, como alimentacao, prevencao de acidentes e crescimento. O desenvolvimento e a educacao da crianca nao sao prioridades e os temas relacionados com o desenvolvimento psicomotor e linguagem sao abordados sobretudo para preencher a historia clinica.
miRNA axis promotes genetic instability 1 HTLV-1 bZIP factor HBZ promotes cell proliferation and genetic instability by activating oncomiRs Running title : HBZ / miRNA axis promotes genetic instability

1. Université de Lyon 1, CNRS UMR5239, Oncovirologie et Biothérapies, Laboratoire de Biologie Moléculaire de la Cellule, Faculté de Médecine Lyon Sud, Pierre Bénite, France. 2. Centre de Recherche sur le Cancer de Lyon, Centre Léon Bérard, Lyon, France 3. Institut Pasteur, Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France 4. Fondation Rothschild, Service de Neurologie, Paris, France 5. CHU Henri Mondor, Laboratoire d'Immunologie, Créteil, France 6. Université Lyon I, Faculté de Médecine et de Pharmacie de Lyon, ISPBL ProfileXpertLCMT, Lyon, France 7. Université Lyon I, Service d'Hématologie, Pavillon Marcel Bérard, Centre Hospitalier Lyon-Sud, Pierre Bénite, France
A Competing Nomogram to Predict Survival Outcomes in Invasive Micropapillary Breast Cancer

Background: Although it is widely accepted that invasive micropapillary carcinoma (IMPC) presents more aggressive behavior and has a higher aggressive behavior, the prognosis of IMPC compared with invasive ductal carcinoma (IDC) remains controversial. We conducted this study to explore gene expression profiles of IMPC and establish a competing nomogram that predicts the survival outcomes across these two groups of patients. Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database were reviewed. Propensity score matching (PSM) was used to adjust for potential baseline confounding between IMPC and IDC group. The Kaplan-Meier method was used to calculate the occurrence of overall mortality. The Gray method was used to estimate the rate of breast cancer specific death (BCSD). A competing regression model was used to evaluate factors associated with BCSD. A nomogram based on the competing risk regression model was established to predict individual outcomes. IMPC-specific gene expression profiles were explored using microarrays data from the Gene Expression Omnibus (GEO) database. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were performed. Results: In this study, 330786 (99.62%) patients with IDC 1247 (0.38%) patients with IMPC were included. Patients with IMPC had more lymph node involvement and a larger tumor size compared with those with IDC. After PSM, many distributional differences were eliminated, showing that the IMPC and IDC group were more similar. Patients with IMPC had a favorable prognosis with statistical significance compared with patients with IDC (overall mortality HR = 0.68; 95%CI, 0.53-0.86; P = 0.002). Based on Gray method, patients with IMPC had a favorable prognosis with significant statistical significance compared with patients with IDC (BCSD SHR = 0.64; 95%CI, 0.47-0.88; P = 0.006). Multivariate analysis based on competing risk model demonstrated that IMPC was a favorable independent factor for BCSD. The nomogram could accurately predict BCSD with a high internal and external validated C-index (0.835, 0.818 respectively). A total of 53 upregulated differentially expressed genes (DEGs) and 40 downregulated DEGs of IMPC was identified. The GO analysis results showed that downregulated DEGs were significantly enriched in extracellular structure organization, extracellular matrix, cell-substrate adhesion junction. KEGG analysis of selective gene sets shows that downregulated DEGs significantly enriched for processes related to carbon metabolism, Rap1 signaling pathway. Conclusion: In the current study, IMPC accounted for 0.38% of the entire cohort. IMPC was found to be a favorable independent prognostic factor. The present study identified gene expression profiles and signal pathways of IMPC. The developed nomogram can help the oncologists to predict individual outcomes more accurately.
A Model of Technology Acceptance and Usage: Case of Ribbon Embroidery SMEs in Indonesia

With the problem of the management and accounting information systems, this study is intended to test the model the use of technology/information systems in Ribbon Embroidery SMEs in Semarang. Several previous studies have been done using a model of the use of technology/information systems, but only partial and not comprehensive. SMEs are in need of a lot of help. This study was able to collect data obtained from 49 respondents are owners, managers and employees of the accounting department or technology/information systems. The results of this study have not been able to prove the effect of performance expectations, business expectations, social factors, facilitating conditions on the behavioral intentions in using technology/information systems. In addition, this research has not succeeded in proving that age moderates the influence of social factors and facilitating conditions on behavioral intentions and the usage of technology/information systems. Experience also has not been proven moderating influence of the business expectations on behavioral intentions. However, self-efficacy and facilitating conditions to significantly affect the behavioral intentions and the usage of technology/information systems. The gender variable was proven to have moderating effect on the influence of performance expectations on behavioral intentions. Experience was proven to have moderating effects on the influence of facilitation conditions on the use of technology/information systems. Keywords : behavioral intentions, usage, information technology, accounting information system.
Firing temperature and firing time influence on mechanical and physical properties of clay bricks

The effects of firing time and temperature on compressive strength, water absorption, bending strength, weight loss, firing shrinkage and densities of clay bricks were determined. For a given clay and method of manufacture, higher compressive and bending strengths, higher density and lower absorptions are associated with higher firing temperatures. Increasing firing time only slightly altered the mechanical and physical properties of clay bricks. However, firing temperature significantly affected the physical properties. The results suggested that firing temperature was the key factor to modulate the physical properties in clay bricks. However, the effect of firing time was not significant. The results obtained in this study can only be compared to the properties of bricks produced under similar conditions with similar raw materials.
Effects of exposure to 50 Hz, 1 Gauss magnetic field on reproductive traits in male albino rats

The effects of extremely low frequency magnetic field ELF-MF (50 Hz/1 Gauss) on male fertility were studied in rats. Twenty eight adult male Wistar rats were divided into 4 groups, 2 experimental groups exposed to magnetic field for 21 days and 2 control groups (sham exposed). The first exposed group was sacrificed at the end of the exposure period, and the second exposed group was kept for extra 48 days post exposure to assess the delayed effects of exposure. Significant decrease in the testes weights, sperm motility, sperm count, normal sperms and live sperms was detected in the exposed groups compared to control. Serum testosterone concentrations were significantly increased after 21 days of exposure, and then these changes were corrected after 48 days post exposure. Superoxide dismutase, catalase activities and α-tocopherol concentration were significantly decreased after 21 days of exposure, while the later became non-significant after 48 days post exposure. L-ascorbate concentration was significantly increased after 21 days of exposure, and returned to normal 48 days post exposure. Histopathological examination of the testis from the exposed rats showed a disruption in its architecture with an increase in Leydig cell number and activity, whereas 48 days post exposure, the testicular germ cell layers increased with presence of high apoptotic rates. In conclusion, prolonged exposure to 50 Hz, 1 Gauss MF is biologically toxic to the testicular functions with oxidative stress on spermatogenesis that subsequently may affect male fertility and his sexual efficiency. Magnetic field, male fertility, testis, sperm, testosterone, antioxidants, delayed effects With the ever-increasing use of the electric technology, electromagnetic fields - especially
Aggressiveness, social support and school experiences as dimensions differentiating negative and positive adaptation among adolescents

participants and procedure The main determinants of the observed changes in behaviour and the development of adaptation pathways during the period of adolescence were considered to include bio-psycho-social temperamental factors (Buss & Plomin, 1984), attachment patterns (Armsden & Greenberg, 1987), trait of aggressiveness (Buss & Perry, 1992), conditions created by the environment (support of family members, peers and teachers [Malecki & Demaray, 2002]) as well as previous experiences such as being a victim of violence (Osterman & Bjorqvist, 2008) or the level of school success. The final study group comprised a total of 140 positively and 140 negatively adapted teenagers (N = 280) between the ages of 12 and 19. The study was carried out in Poland.
Comparative Study of Three Techniques of Palatoplasty in Patients with Cleft of lip and palate via Instrumental and Auditory-perceptive Evaluations

Instituição: Universidade Federal do Rio Grande do Sul (UFRGS). Porto Alegre / RS – Brasil. Endereço para correspondência: Lauren Medeiros Paniagua – Avenida João Wallig, 1705, Apto. 267 – Porto Alegre / RS – Brasil – CEP: 91340-001 – Telefone: (+55 51) 3273-5173 – E-mail: tchelauren@yahoo.com. br Apoio Financeiro: Bolsa CNPq Artigo recebido em 1o de Julho de 2009. Artigo aprovado em 3 de Janeiro de 2010.
DP 2011-06 Productivity distribution , firm heterogeneity , and agglomeration : Evidence from firm-level data

This paper empirically examines how productivity distributions of firms vary across regions based on Japan’s manufacturing census data. We find that firm productivity is distributed with wide dispersions, especially in core regions. Our firm-level estimates demonstrate that the productivity distribution of firms tends to be noticeably left-skewed, deviating from the normal distribution, especially in regions with weak market potential but also in agglomerated or urbanized regions. These findings suggest that agglomeration economies are likely to accommodate heterogeneous firms that co-exist in the same region.
AN IMPROVED ENERGY BASED LOAD-DISPLACEMENT PREDICTION FOR SLOTTED DISC SPRING

An improved calculation of the load-displacement prediction for a slotted disc spring is proposed. There are two types of slotted disc spring; a straight slotted disc spring and a bended slotted disc spring. By considering these two types of slotted disc spring, this work attempts to extend the previous work on load-displacement prediction for the slotted disc spring using the energy method. To show the validity of the improved method, the load-displacement results using the improved computation, the previous proposed method, and the finite element analyses are compared. In this work, the improved computation and the finite element analyses have accounted for the radial deflection of the disc spring which is different in the previous work. The radial deflection of the disc spring was ignored in the previous work and the comparison to the finite element analyses without accounting the radial deflection is not practical. The present work is compared to the finite element analyses which make the comparison to be more reasonable and more practical.
Title Polymorphisms in melatonin synthesis pathways : Possible influences on depression Permalink

Background: It has been reported that rs4446909, a single nucleotide polymorphism (SNP) in the promoter of acetylserotonin methyltransferase (ASMT), influences the expression of the ASMT enzyme. The common G allele is associated with lower ASMT activity, and therefore, diminishes conversion of N-acetylserotonin to melatonin. The G allele was associated with recurrent depressive disorder in a Polish group. ASMT might also affect bipolar relapse, given evidence that N-acetylserotonin might stimulate TRKB receptors, and TRKB may influence mood relapse in bipolar disorder. Additionally, arylalkylamine N-acetyltransferase (AANAT) polymorphisms have been reported associated with depression, perhaps through their influence upon N-acetylserotonin or melatonin synthesis. Results: To replicate and further explore these ideas, rs4446909 was genotyped in four research groups, as part of a panel of 610 SNPs surveyed by an Illumina Golden Gate assay. In 768 cases with delayed sleep phase disorder or matched controls, rs4446909 was indeed associated with the depressive symptoms on a self-report scale (P = 0.01, R = 0.007). However, there was no significant association of rs4446909 with self-reported depression in a sleep clinic patient group or with two groups of elderly men and women from multicenter studies, nor was the response to lithium treatment associated with rs4446909 in bipolar patients. No associations of two AANAT SNPs with depression were found. Conclusions: The evidence did not support a strong influence of rs4446909 upon mood, but the partial replication may be consistent with a modest effect. It is possible that larger or younger subject groups with improved phenotype ascertainment might demonstrate more persuasive replication.
Recapitulates Human Reactive Stroma Signaling in Prostate Cancer Mouse Models β TGF-− WNT − FGFR 1

The reactive stroma surrounding tumor lesions performs critical roles ranging from supporting tumor cell proliferation to inducing tumorigenesis and metastasis. Therefore, it is critical to understand the cellular components and signaling control mechanisms that underlie the etiology of reactive stroma. Previous studies have individually implicated fibroblast growth factor receptor 1 (FGFR1) and canonicalWNT/b-catenin signaling in prostate cancer progression and the initiation and maintenance of a reactive stroma; however, both pathways are frequently found to be coactivated in cancer tissue. Using autochthonous transgenic mouse models for inducible FGFR1 (JOCK1) and prostate-specific and ubiquitously expressed inducible b-catenin (Pro-Cat and Ubi-Cat, respectively) and bigenic crosses between these lines (Pro-Cat JOCK1 and Ubi-Cat JOCK1), we describeWNT-induced synergistic acceleration of FGFR1-driven adenocarcinoma, associated with a pronounced fibroblastic reactive stroma activation surrounding prostatic intraepithelial neoplasia (mPIN) lesions found both in in situ and reconstitution assays. Both mouse and human reactive stroma exhibited increased transforming growth factor-b (TGF-b) signaling adjacent to pathologic lesions likely contributing to invasion. Furthermore, elevated stromal TGF-b signaling was associated with higher Gleason scores in archived human biopsies, mirroring murine patterns. Our findings establish the importance of the FGFR1–WNT–TGF-b signaling axes as driving forces behind reactive stroma in aggressive prostate adenocarcinomas, deepening their relevance as therapeutic targets. Cancer Res; 74(2); 609–20. 2013 AACR.
Voice Activity Detection by Upper Body Motion Analysis and Unsupervised Domain Adaptation

We present a novel vision-based voice activity detection (VAD) method that relies only on automatic upper body motion (UBM) analysis. Traditionally, VAD is performed using audio features only, but the use of visual cues instead of audio can be desirable especially when audio is not available such as due to technical, ethical or legal issues. Psychology literature confirms that the way people move while speaking is different from while they are not speaking. This motivates us to claim that an effective representation of UBM can be used to detect "Who is Speaking and When". On the other hand, the way people move during their speech varies a lot from culture to culture, and even person to person in the same culture. This results in unrelated UBM representations, such that the distribution of training and test data becomes disparate. To overcome this, we combine stacked sparse autoencoders and simple subspace alignment methods while a classifier is jointly learned using the VAD labels of the training data only. This yields new domain invariant feature representations for training and test data, showing improved VAD results. Our approach is applicable to any person without requiring re-training. The tests applied on a publicly available real-life VAD dataset show better results as compared to the state-of-the-art video-only VAD methods. Moreover, the ablation study justifies the superiority of the proposed method and demonstrates the positive contribution of each component.
Women : A Randomized Controlled Trial Inflammatory Biomarkers in Overweight / Obese Postmenopausal Effects of a Caloric Restriction Weight Loss Diet and Exercise on

Obese and sedentary persons have increased risk for cancer; inflammation is a hypothesized mechanism. We examined the effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in 439 women. Overweight and obese postmenopausal women were randomized to 1-year: caloric restriction diet (goal of 10% weight loss, N1⁄4 118), aerobic exercise (225 min/wk of moderate-to-vigorous activity, N1⁄4 117), combined diet þ exercise (N 1⁄4 117), or control (N 1⁄4 87). Baseline and 1-year high-sensitivity C-reactive protein (hs-CRP), serumamyloidA (SAA), interleukin-6 (IL-6), leukocyte, andneutrophil levelsweremeasured by investigators blind to group. Inflammatory biomarker changes were compared using generalized estimating equations. Models were adjusted for baseline bodymass index (BMI), race/ethnicity, and age. Four hundred and thirty-eight (N1⁄4 1 in diet þ exercise group was excluded) were analyzed. Relative to controls, hs-CRP decreased by geometric mean (95% confidence interval, P value): 0.92mg/L (0.53–1.31, P< 0.001) in the diet and 0.87mg/L (0.51–1.23, P< 0.0001) in the dietþ exercise groups. IL-6 decreased by 0.34 pg/mL (0.13–0.55, P1⁄4 0.001) in the diet and 0.32 pg/mL (0.15–0.49, P < 0.001) in the diet þ exercise groups. Neutrophil counts decreased by 0.31 10/L (0.09–0.54, P 1⁄4 0.006) in the diet and 0.30 10/L (0.09–0.50, P1⁄4 0.005) in the dietþ exercise groups. Diet anddietþ exercise participantswith 5% or more weight loss reduced inflammatory biomarkers (hs-CRP, SAA, and IL-6) compared with controls. The diet and dietþ exercise groups reduced hs-CRP in all subgroups of baseline BMI, waist circumference, CRP level, and fasting glucose. Our findings indicate that a caloric restriction weight loss diet with or without exercise reduces biomarkers of inflammation in postmenopausal women, with potential clinical significance for cancer risk reduction. Cancer Res; 72(9); 2314–26. 2012 AACR.