Miracle-dz/UniFAR-FTUs huggingface dataset:
Gold Nanoparticle Based Surface-Enhanced Raman Scattering Spectroscopy of Cancerous and Normal Nasopharyngeal Tissues under Near-Infrared Laser Excitation

The capabilities of using gold nanoparticle based near-infrared surface-enhanced Raman scattering (SERS) to obtain biochemical information with high spatial resolution from human nasopharyngeal tissue were presented in this paper. The gold nanoparticles used have a mean diameter of 43 nm with a standard deviation of 6 nm. The SERS bands of nasopharyngeal tissue were assigned to known molecular vibrations of nucleic acids, amino acids, proteins, and metabolites. We also observed the blinking phenomenon at the tissue level when measuring the nasopharyngeal tissue SERS spectra, most frequently in signal intensity but also occasionally in peak positions. This phenomenon is excitation light intensity dependent. This work demonstrated great potential for using SERS imaging for distinguishing cancerous and normal nasopharyngeal tissues on frozen sections without using any dye labeling or other chemical species as functionalized binding sites.
Developmental cell interactions of Myxococcus xanthus: analysis of mutants

A set of developmental mutants have been examined that behave as if defective in cellular interactions necessary for the formation of myxospores during fruiting body development. Sporulation is rescued in these mutants if they are mixed with wild-type cells. Complementation experiments with whole cells divide the mutants into four groups (A, B, C, and D). Mutants of group A appear to be less responsive to starvation, a condition that normally initiates development. Mutants of group D respond to starvation but fail to synthesize myxobacterial hemagglutinin, a protein normally synthesized midway in development. Mutants of groups B and C respond to starvation and synthesize hemagglutinin, but they can be distinguished genetically. Group C mutations all map in a single cluster near insertion omega 1519 of transposon Tn5, which is distant from group B mutations. Thus, each group represents a different defect in development. All of the mutants are induced to sporulate by glycerol. Therefore, we argue that sporulation during fruiting body development depends on several prior interactions between cells.
Characterization of thromboxane A2/prostaglandin H2 binding sites in guinea pig cardiac membrane preparations.

Thromboxane A2 (TXA2) and prostaglandin H2 (PGH2) induce platelet aggregation and are potent vasoconstrictors, and they have been implicated in coronary vasospasm and myocardial infarction. The TXA2 mimetic [1S-(1 alpha, 2 beta (5Z), 3 alpha (1E,3S*), 4 alpha)]-7-[3-(3-hydroxy-4-(4'- iodophenoxy)-1-butenyl)-7-oxabicyclo-[2.2. 1]heptan-2-yl]-5-h eptenoic acid (IBOP) was used to characterize binding to microsomal membrane preparations from saline-perfused guinea pig atria (GPA) and ventricles (GPV). [125I]IBOP bound to GPA and GPV in a protein-dependent and saturable manner, although total binding was two-fold greater and non-specific binding was proportionately less in GPA compared to GPV. Analysis of equilibrium binding data indicated one class of binding sites in both GPA and GPV with Kd values of 333 +/- 117 and 645 +/- 187 pM, respectively, which were in close agreement with kinetically determined Kd values of 226 and 882 pM, respectively. Bmax values of GPA and GPV of 57 +/- 5.6 and 24 +/- 4.3 fmol/mg protein were significantly different (P < 0.01). Ki values (from IC50s) were determined for various TXA2/PGH2 analogues and prostaglandins in competition binding assays with [125I]IBOP. The rank order for ability to inhibit binding in GPA was U46619 = SQ29548 > I-PTA-OH > PGF2 alpha = PGE2. In GPV, the rank order was U46619 = SQ29548 > PGF2 alpha = I-PTA-OH = PGE2. [125I]IBOP binding to GPA and GPV was completely displaced by the TXA2/PGH2 agonist U46619 and by the TXA2/PGH2 antagonist SQ29548. (ABSTRACT TRUNCATED AT 250 WORDS)
Systemic Lupus Erythematosus: Predisposition for Uterine Cervical Dysplasia

A previous retrospective study has found an increased risk of uterine cervical atypia in women with systemic lupus erythematosus (SLE) who have been treated with cytotoxic drugs. Our objective was to prospectively reveal any increased incidence of cervical atypia in SLE patients and to evaluate the relationship to previous chemotherapy. A total of 39 SLE women were prospectively referred for cytologic PAP smears of the uterine cervix. A significantly higher incidence of cervical atypia was found in SLE women (35.9%) compared with non-SLE control groups (≤5%; P < 0.01). No significant difference was found between the incidence of atypia in patients previously treated by cytotoxic medications such as cyclophosphamide pulses or methotrexate (4 of 9) compared with SLE women not receiving cytotoxic drugs (10 of 30). Colposcopically directed biopsies revealed three cases of cervical intraepithelial neoplasia (CIN) I-III (23%) among the cases with atypia. We conclude that women with SLE should have regular cytologic cervical smears because of a significantly increased incidence of atypia, regardless of previous cytotoxic therapy.
Productive aging, work engagement and participation of older workers. A triadic approach to health and safety in the workplace

Background Aging of the workforce poses a dramatic challenge for health and safety in all European countries. Method Our study was based on a comprehensive review of the literature on productive aging, work engagement, and human engineering, with particular reference to older worker issues. Results Productive aging, work engagement, and participatory ergonomics appear to be the most promising areas of research in the field of worker aging. An analysis of intervention programs enabled us to identify three main approaches that could be used to tackle the problem. These include encouraging older adults to be involved in work activities, enhancing their work engagement, and sustaining their productive efforts through participatory changes in the working environment and the promotion of healthy lifestyles. Occupational health and safety services in the workplace must extend their activities of prevention to encompass not only traditional environmental risk factors, but also non-occupational risk factors, so that this holistic approach promotes good practices and positive attitudes. Conclusions A set of recommendations and policy briefs for supra-national, national and local authorities was formulated.
Thrombosis and Factor VII Activity

The tests for the coagulation time of the blood which are in general use have contributed little to the understanding of abnormal tendencies to thrombosis, as they are extremely insensitive to all but gross changes in the coagulation mechanism. A variety of techniques have been evolved to meet this defect. One group of these methods depends on the addition of an inhibitor, e.g., heparin, to the routine clotting time method (Waugh and Ruddick, 1944; Silverman, 1948). It has been shown, using a heparin sensitized method (Poller, 1956), that statistically the coagulation time is significantly shortened 48 hours after a thrombo-embolic episode. The drawbacks to the use of such methods as simple prediction tests have been discussed (Poller, 1955). As thromboplastin and heparin are to a large extent mutually antagonistic in action, and shortened heparin plasma clotting times have been found in the first few days after operation when tissue damage and other factors may cause an increase in thromboplastin activity, it may be supposed that increased resistance to heparin may be related to the ability to produce thromboplastin in the plasma of such patients. An investigation of various aspects of thromboplastin production was therefore performed in a group of patients and parallel controls. Prothrombin activity, factor V and VII activity, and the production of thromboplastin in the thromboplastin generation test were studied in both groups, together with heparin plasma clotting times. In view of the recently established effect of chylomicra on the coagulation time (Poole, 1955), serum cholesterol values were determined in both groups as a feature of secondary interest.
PENGARUH GAYA KEPEMIMPINAN TERHADAP KOMITMEN ORGANISASI MELALUI ASPEK KEPUASAN KERJA KARYAWAN DAN KEPERCAYAAN PADA SEKTOR PERBANKAN

This research refers to the previous research which has done by Chiang and Wang (2012) and also completed by Kalber and Cenker (2007). This research is about “the impact of leadership style on organization commitment mediating by job satisfaction and trust on employed at bank sectors”. The background of this research is to know the impact of leadership style on organization commitment. The purpose of this research is to examine the impact of leadership style on organization commitment mediating by job satisfaction and trust. The research is using primary data by spreading questionnaires to 250 employes of banking sectors in DKI Jakarta, such as: Bank Mandiri, Bank Negara Indonesia, Bank Jabar, Bank Bukopin and Bank Central Asia during 2015, however there are 201 questionnaires were returned. The method of data analysis used is Structural Equation Model (SEM). The result of this research concludes that there are positive impacts of leadership style on organization commitment mediating by job satisfaction and trust. Keywords: Leadership Style, Job Satisfaction, Trust, Organization Commitment, Banking Sectors.
MEDIASI PROFITABILITAS PADA HUBUNGAN ANTARA GOOD CORPORATE GOVERNANCE DAN FIRM SIZE TERHADAP CORPORATE SOCIAL RESPONSIBILITY

This research aimed to analyze the mediating effect of profitability on therelationship of good corporate governance and firm size to corporate socialresponsibility. The population were 29 firm of Indonesia trusted companies based onthe survey of Indonesia Institute for Corporate Governance in Indonesia StockExchange from 2014 – 2015. The sampling technique used was purposive sampling.Based on the sampling criteria, the number of selected samples were 20 firms. Dataanalysis used was path analysis method. The research findings were: 1). Goodcorporate governance had no effect to profitability and corporate social responsibility,2). Firm size and profitability had positive influence on corporate socialresponsibility.3). Firm size had negative effect to profitability. 4). Profitability did notmediate the relationship of good corporate governance and firm size to corporate socialresponsibility.
Technical report bds : 00-07 Equivalence of hybrid dynamical models

This paper establishes equivalences among five classes of hybrid systems: mixed logical dynamical (MLD) systems, linear complementarity (LC) systems, extended linear complementarity (ELC) systems, piecewise affine (PWA) systems, and maxmin-plus-scaling (MMPS) systems. Some of the equivalences are established under (rather mild) additional assumptions. These results are of paramount importance for transferring theoretical properties and tools from one class to another, with the consequence that for the study of a particular hybrid system that belongs to any of these classes, one can choose the most convenient hybrid modeling framework.
Cognitive behavioral therapy for the treatment of binge eating disorder: what constitutes success?

In the historical development of psychiatric nosology, as in the rest of medicine, more severe disorders tend to be recognized before disorders with milder symptom profiles. Thus, psychiatric classifications recognized schizophrenia and melancholia before schizotypal personality disorder and dysthymia. So, too, with the classification of eating disorders; anorexia nervosa, which may result in death, was recognized many years before bulimia nervosa. The most recent addition to the psychiatric classification of eating disorders is “binge eating disorder. ” The diagnosis of binge eating disorder is given to the many obese individuals who are distressed by recurrent binge eating, yet do not regularly engage in the compensatory behavior (e.g., vomiting or use of laxatives) that is seen in individuals with bulimia nervosa. Although binge eating disorder is not an official DSM-IV diagnosis, a variety of studies support its validity (1–4). A description of the disorder and its diagnostic criteria appear in DSM-IV Appendix B, titled “Criteria Sets and Axes Provided for Further Study. ” Binge eating disorder is common among study groups drawn from weight-control programs (15%–50%), which show women are approximately 1.5 times more likely to have the disorder than men. In nonpatient community samples, a prevalence rate of 1%–4% has been reported (1, 3). Typically, the disorder begins in late adolescence or in the early 20s, often after weight loss from severe dieting. Common associated features include marked fluctuations in weight over time and a history of depression, anxiety, low self-esteem, somatic concern, and interpersonal sensitivity. Along with the recognition of binge eating disorder and its clinical features, there has been increasing interest in developing effective treatments for the disorder. Several studies have examined the relative efficacy of psychotherapeutic and psychopharmacological approaches (5). This case conference illustrates some of the challenges and rewards involved in the treatment of a patient with binge eating disorder.
Statistical mechanics of cosmic strings.

An analytic approach to the phase space for a network of cosmic strings is presented, based on earlier work of Frautschi and Carlitz. It correctly predicts the main features of the network at formation, and is in good agreement with the picture emerging from string simulations. Our results also have important implications for superstrings or heterotic strings in the early Universe.
The essential order of approximation for neural networks

There have been various studies on approximation ability of feedforward neural networks (FNNs). Most of the existing studies are, however, only concerned with density or upper bound estimation on how a multivariate function can be approximated by an FNN, and consequently, the essential approximation ability of an FNN cannot be revealed. In this paper, by establishing both upper and lower bound estimations on approximation order, the essential approximation ability (namely, the essential approximation order) of a class of FNNs is clarified in terms of the modulus of smoothness of functions to be approximated. The involved FNNs can not only approximate any continuous or integrable functions defined on a compact set arbitrarily well, but also provide an explicit lower bound on the number of hidden units required. By making use of multivariate approximation tools, it is shown that when the functions to be approximated are Lipschitzian with order up to 2, the approximation speed of the FNNs is uniquely determined by modulus of smoothness of the functions.
Influence of Dynamic Strength Index on Countermovement Jump Force-, Power-, Velocity-, and Displacement-Time Curves

The dynamic strength index (DSI), often calculated as the ratio of countermovement jump (CMJ) propulsion peak force to isometric mid-thigh pull (IMTP) peak force, is said to inform whether ballistic or maximal strength training is warranted for a given athlete. CMJ propulsion peak force is highly influenced by jump strategy, however, which is not highlighted by the DSI alone. This study aimed to quantitatively compare CMJ force-, power-, velocity-, and displacement-time curves between athletes who achieved high versus low DSI scores. Fifty-three male collegiate athletes performed three CMJs and IMTPs on a force platform. Athletes were ranked based on DSI score and the CMJ kinetic and kinematic-time curves of the bottom and top twenty athletes were compared. The low DSI group (0.55 ± 0.10 vs. 0.92 ± 0.11) produced greater IMTP peak force (46.7 ± 15.0 vs. 31.1 ± 6.6 N·kg−1) but a larger braking net impulse in the CMJ, leading to greater braking velocity and larger countermovement displacement. This strategy resulted in a similar CMJ propulsion peak force (25.9 ± 2.2 vs. 25.4 ± 3.1 N·kg−1) to the high DSI group. These results, taken together with those of previous studies, support the notion of ballistic versus maximal strength training likely being better suited to low versus high DSI scorers, respectively.
Expression of epidermal growth factor receptors in four histologic cell types of lung cancer

Lung cancer tissues from 68 patients were examined for epidermal growth factor (EGF) receptor levels and EGF receptor gene copy numbers. Histologic cell types of these lung cancer tissues included squamous‐cell carcinoma (n = 30), adenocarcinoma (n = 28), large‐cell carcinoma (n = 4), and small‐cell carcinoma (n = 6). Tissues of squamous‐cell carcinoma exhibited exceptionally high 125I‐EGF binding activity, and those of small‐cell carcinoma showed no EGF binding activity. Southern blot hybridization analysis revealed EGF receptor gene amplification in the squamous‐cell carcinomas with high EGF binding activity. The EGF receptor levels in squamous‐cell carcinomas and adenocarcinomas were compared with their pathological staging grouping and pathological findings, including degree of differentiation, diameter of tumor, and lymph node metastasis. However, unlike previous reports on breast and bladder cancers, there was no obvious correlation between these pathological characteristics and the EGF receptor levels of lung cancer.
Women in the workforce

This article reviews the participation of female employees in the Malaysian labour market. It seeks to highlight female significance and contribution towards Malaysian economy. The Malaysian government has projected an increase of female in the workforce in order to achieve a high-income nation by the year 2020; however female employees are still underutilized in the Malaysian labour market compared to male. This article discusses various issues and challenges faced by female employees particularly concerning sexist human resource practices in the recruitment, appraisal, as well as in the benefits and compensation practices.
A Fisherian Approach to the Dividend Puzzle: Taxes, Consumption, and Risk Diversification

This paper presents an alternative theory explaining why firms adopt dividend policies of various kinds at intermediate levels. We extend the dividend clientele model from a traditional corner-solution framework to an interior-solution framework. For some investors, intertemporal double taxation and transaction costs produce a V-shaped function that is inflected at the point where the dividend payment just satisfies the investor's current liquidity needs. Because, generally speaking, clientele effects and risk diversification are not completely compatible, a firm's dividend pattern is expected to be consistent with the median shareholder's intertemporal consumption allocation when consumption preferences dominate tax preferences for majority shareholders.
CROSS-SECTIONAL VARIATION IN STOCK RETURNS: EVIDENCE FROM AN EMERGING MARKET

Fama and French (1992) reported that the two fundamental factors, size and book-to-market (BM) explains the cross-sectional variation in stock returns and the relationship between beta and average returns is flat. This study reports the market risk as the most significantly priced factor for Pakistan? s stocks. Investors in Pakistan? s equity market are compensated for the size, BM and momentum factors, but the relationship between risk and return as given by Capital Asset Pricing Model (CAPM) is strong and remains powerful even with the addition of size, BM and momentum factors. The significant role of beta reported for Pakistan? s stocks justifies the use of CAPM in stock valuation.
Effective Antibiotic Treatment of Methicillin-Resistant Staphylococcus aureus-Associated Glomerulonephritis

Background: A new type of glomerulonephritis following a methicillin-resistant Staphylococcus aureus (MRSA) infection has been reported. The purpose of this study is to elucidate the clinicopathological features and the responsiveness to treatment of the disease. Methods: We studied the treatment of 8 patients with glomerulonephritis related to MRSA infection. We observed the eight cases and analyzed clinical features, laboratory findings and histopathological data. Results: On admission, all patients had no renal abnormalities. One to four months after suffering from MRSA infection, severe proteinuria and hematuria developed. Renal biopsy specimens revealed moderate to severe mesangial proliferative glomerulonephritis with various degrees of crescent formation. Immunofluorescence studies showed IgA and C3. Antibiotic therapy was performed in six cases, resulting in successfully reducing the proteinuria in parallel with the decreased activity of MRSA infection in five cases. The other 2 cases received corticosteroid treatment after complete cessation of MRSA infection, but they had a relapse of MRSA infection and later died from sepsis. Conclusions: These results suggested that MRSA-associated glomerulonephritis might respond to antibiotic treatment in most cases. This also indicated that special care must be taken in the application of steroid therapy for the glomerulonephritis with crescents, even though the MRSA infection has gone into an inactive state.
Nitric Oxide Mediates Nitrite-Sensing and Acclimation and Triggers a Remodeling of Lipids1

In Phaedactylum, NO produced from nitrite by the nitrate reductase up-regulates the expression of genes involved in nitrite assimilation into amino acids and triggers a remodeling of lipids. Nitric oxide (NO) is an intermediate of the nitrogen cycle, an industrial pollutant, and a marker of climate change. NO also acts as a gaseous transmitter in a variety of biological processes. The impact of environmental NO needs to be addressed. In diatoms, a dominant phylum in phytoplankton, NO was reported to mediate programmed cell death in response to diatom-derived polyunsaturated aldehydes. Here, using the Phaeodactylum Pt1 strain, 2E,4E-decadienal supplied in the micromolar concentration range led to a nonspecific cell toxicity. We reexamined NO biosynthesis and response in Phaeodactylum. NO inhibits cell growth and triggers triacylglycerol (TAG) accumulation. Feeding experiments indicate that NO is not produced from Arg but via conversion of nitrite by the nitrate reductase. Genome-wide transcriptional analysis shows that NO up-regulates the expression of the plastid nitrite reductase and genes involved in the subsequent incorporation of ammonium into amino acids, via both Gln synthesis and Orn-urea pathway. The phosphoenolpyruvate dehydrogenase complex is also up-regulated, leading to the production of acetyl-CoA, which can feed TAG accumulation upon exposure to NO. Transcriptional reprogramming leading to higher TAG content is balanced with a decrease of monogalactosyldiacylglycerol (MGDG) in the plastid via posttranslational inhibition of MGDG synthase enzymatic activity by NO. Intracellular and transient NO emission acts therefore at the basis of a nitrite-sensing and acclimating system, whereas a long exposure to NO can additionally induce a redirection of carbon to neutral lipids and a stress response.