Miracle-dz/UniFAR-FTUs huggingface dataset:
Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia

Essential thrombocythemia is a myeloproliferative neoplasm characterized by an increased risk of both arterial and venous thrombosis. The findings of this study show that patients with this disorder have elevated levels of platelet-and endothelium-derived microparticles, which may support thrombin generation and play a role in the pathophysiology of thromboembolic complications. Background Most cell types, including blood - and vascular cells, produce microparticles upon activation. Since cellular microparticles are known to be elevated in thromboembolic diseases, we hypothesized a role for microparticles in the pathogenesis of thrombosis in essential thrombocythemia. Design and Methods In plasma samples from 21 patients with essential thrombocythemia and ten healthy subjects, the levels and the cellular origin of microparticles were determined by flowcytometric analysis, while the microparticle-associated procoagulant activity was measured using a thrombin generation assay. Results Patients with essential thrombocythemia had significantly higher numbers of circulating annexin V-positive microparticles than controls (median 4500 vs. 2500×106 events/L; p=0.039), including significantly higher numbers of microparticles positive for the platelet marker CD61 (p=0.043), the endothelial markers CD62E (p=0.009) and CD144 (p=0.021), and for tissue factor (p=0.036). CD62E was co-expressed with the platelet marker CD41 on microparticles, suggesting a bilineage origin of such microparticles, which were observed only in patients with risk factors for thrombosis. Patients with essential thrombocythemia had higher plasma levels of mature von Willebrand factor (p=0.045) but similar propeptide levels compared to controls. In thrombin generation analyses, microparticle-rich plasma from patients with essential thrombocythemia had a shorter lag time (p=0.001) and higher peak height (p=0.038) than plasma from controls. Peak height correlated significantly with the total number of microparticles (R=0.634, p<0.001). Conclusions Patients with essential thrombocythemia had higher number of circulating microparticles with platelet and endothelial markers, suggesting ongoing platelet and endothelial activation. This was confirmed by an increased level of mature von Willebrand factor, an abnormal mature von Willebrand factor/propeptide ratio, and a hypercoagulable state reflected in thrombin generation. These findings suggest a role for microparticles in thrombosis in essential thrombocythemia.
Knowledge exchange types and strategies on the innovation interactions between KIBS firms and their clients in Taiwan

Abstract This investigation discusses the innovative activities of Knowledge-Intensive Business Services (KIBS) in the developmental process. To improve understanding of KIBS, the study aims to understand empirically the functions and mechanisms of knowledge intermediaries in different organizations and developmental processes, and also explores knowledge exchange and factors affecting KIBS. This study performs an empirical analysis of KIBS based on a recent manufacturer survey and emphasizes the connections among KIBS, innovation and forms of knowledge. The research results indicate the following conclusions: (1) Taiwanese KIBS enterprises tend to exchange knowledge with clients through mixed and codified knowledge; (2) firms that rely mainly on the exchange of codified knowledge have improved connections with clients, technologies, research innovation and application of advanced technologies; (3) enterprises mainly exchange mixed knowledge, and focus on knowledge management and information sources required during innovation processes, and (4) fewer enterprises exchange knowledge through tacit knowledge. The research implication is that enterprises emphasize different factors based on different types of knowledge exchange and services.
Effects of Poverty on Impatience: Preferences or Inattention?

We study two psychological channels how poverty may increase impatient behavior - an effect on time preference and reduced attention. We measured discount rates among Ugandan farmers who made decisions about when to enjoy entertainment instead of working. We find that experimentally induced thoughts about poverty-related problems increase the preference to consume entertainment early and delay work. The effect is equivalent to a 27 p.p. increase in the intertemporal rate of substitution. Using monitoring tools similar to eye tracking, a novel feature for this subject pool, we show this effect is not due to a lower ability to sustain attention.
COMPARISON OF SURFACE HYDROPHOBICITY OF PILIATED AND NON-PILIATED CLONES OF CORYNEBACTERIUM RENALE AND CORYNEBACTERIUM PILOSUM AND DNA HOMOLOGY STUDY OF PROBABLE NEW SPECIES OF GENUS CORYNEBACTERIUM ISOLATED FROM THE URINARY TRACT OI HOGS

Piliated (p+) and non-piliated (P) clonse of Corynebacterium renale and C. pilosum were similar in hydrophobicity as measured by hydrophobic interaction chro matography, bacterial adherence to hydrocarbons and the salt aggregation test. Therefore, the presiously reported adherence of p+ clone to various cells, which is more effective than that of P - clone of these bacteria
Reduced risk for extensive chronic graft-versus-host disease in patients receiving transplants with human leukocyte antigen-identical sibling donors given polymerase chain reaction-based preemptive therapy against cytomegalovirus

Background. The aim of this study was to investigate the relationship between cytomegalovirus (CMV) and extensive chronic graft-versus-host disease (GvHD) after allogeneic stem-cell transplantation (SCT). Methods. Two hundred sixty-two consecutive patients undergoing conventional SCT with human leukocyte antigen-identical sibling donors, given cyclosporine A and methotrexate as GvHD prophylaxis and surviving more than 3 months after SCT, were retrospectively analyzed. Most patients received transplants because of a hematologic malignancy (n=226), but 36 patients with nonmalignant disorders were included in the analysis. Ninety-nine patients were monitored for CMV infection with rapid virus isolation and 163 patients by either a pp65 antigenemia test (n=5) or a qualitative polymerase chain reaction (PCR) assay for CMV-DNA (n=158). Results. One hundred thirty (50%) of the patients developed chronic GvHD, of whom 17 (6.5%) developed extensive chronic GvHD. Risk factors for development of extensive chronic GvHD were determined by multivariate logistic regression. The strategy of PCR-based monitoring for CMV-DNA, giving preemptive antiviral therapy on demand, significantly decreased the risk for developing extensive chronic GvHD (odds ratio=0.32, P =0.03). No other factors tested, including recipient and donor age and sex, source of graft, cell dose, and acute GvHD, had any significant effect on the development of extensive chronic GvHD. Conclusions. We conclude that the risk for extensive chronic GvHD in this homogenous group of patients was reduced by the use of PCR-based preemptive therapy.
Microsatellite DNA variation in Bornean orangutans (Pongo 
pygmaeus)

Orangutans (Pongo pygmaeus) on the islands of Borneo and Sumatra are considered two separate subspecies. However, the genetic relationships between isolated populations on Borneo are not clear. This study determined the extent of variation within the Bornean subspecies of orangutan, using microsatellite DNA analysis. Blood samples were collected from 96 individuals of known origin from East, West and Central Kalimantan. Human microsatellite primer pairs located at human map position D2S141, D4S431, D11S925, D16S420 and D17S791 were suitable for use in primates. D4S431 appeared monomorphic for all orangutans. In three cases (D2S141 East and West and D16S420 West), a highly significant excess of homozygous allele frequencies was detected, but with other primer pairs no significant difference in allele frequencies occurred. We conclude that the divergence between the different populations on Borneo is less than the variation within the populations. There was also evidence that inbreeding occurred within the populations.
Variability modeling of RF characteristics for multi-finger MOSFETs using statistical methods

In this paper, the AC circuit model of multi-finger MOSFET for RF application is investigated. Test structures varying with the gate width and the number of fingers are fabricated in 0.35-μm TSMC process. The s-parameters of test structures are measured from 50MHz to 10GHz. The equivalent circuit model is proposed by hybrids of BSIM3 and the parasitic components. The parasitic components are extracted by optimizing the parameters using the measured DC and RF characteristics. Based on the extracted circuit models, the extracted parameters are verified by the analysis of variance.
Fine-temporal forecasting of outbreak probability and severity: Ross River virus in Western Australia

SUMMARY Health warnings of mosquito-borne disease risk require forecasts that are accurate at fine-temporal resolutions (weekly scales); however, most forecasting is coarse (monthly). We use environmental and Ross River virus (RRV) surveillance to predict weekly outbreak probabilities and incidence spanning tropical, semi-arid, and Mediterranean regions of Western Australia (1991–2014). Hurdle and linear models were used to predict outbreak probabilities and incidence respectively, using time-lagged environmental variables. Forecast accuracy was assessed by model fit and cross-validation. Residual RRV notification data were also examined against mitigation expenditure for one site, Mandurah 2007–2014. Models were predictive of RRV activity, except at one site (Capel). Minimum temperature was an important predictor of RRV outbreaks and incidence at all predicted sites. Precipitation was more likely to cause outbreaks and greater incidence among tropical and semi-arid sites. While variable, mitigation expenditure coincided positively with increased RRV incidence (r 2 = 0·21). Our research demonstrates capacity to accurately predict mosquito-borne disease outbreaks and incidence at fine-temporal resolutions. We apply our findings, developing a user-friendly tool enabling managers to easily adopt this research to forecast region-specific RRV outbreaks and incidence. Approaches here may be of value to fine-scale forecasting of RRV in other areas of Australia, and other mosquito-borne diseases.
Successful treatment of Providencia rettgeri cholecystitis and neutrophilic cholangitis in a cat

Case summary A 15-year-old male neutered domestic shorthair cat was presented with a recent history of seizures, diarrhoea, lethargy, fever and jaundice. Marked elevation of liver enzyme activity was present and ultrasound examination was suggestive of cholecystitis and hepatitis. Neutrophilic cholangitis was confirmed on histopathology of liver biopsies. Bile culture identified a monomicrobial infection with Providencia rettgeri, which was resistant to multiple antimicrobial agents. The cat was treated with oral pradofloxacin for 4 weeks and remained well 4 months later. Relevance and novel information Providencia species are rarely reported in the veterinary literature and are an uncommon cause of disease in humans. The significance of this species in humans relates to the high prevalence of antimicrobial resistance. This is the first report of P rettgeri causing clinical illness in a cat and highlights the importance of bile cultures in hepatic disease.
Prospective of Societal and Environmental Benefits of Piezoelectric Technology in Road Energy Harvesting

Road energy harvesting is an ingenious horizon for clean and renewable energy production. The concept is very compatible with current traffic trends and the ongoing depletion of natural resources. Yet, the idea of harvesting roadway energy is still in its genesis, and only a few real-time implementation projects have been reported in the literature. This review article summarizes the current state of the art in road energy harvesting technology, with a focus on piezoelectric systems, including an analysis of the impact of the technology from social and environmental standpoints. Based on an extensive desktop review study, this article provides a comprehensive insight into roadway energy harvesting technologies. Specifically, the article discusses the societal and environmental benefits of road energy harvesting technologies, as well as the challenges. The study outlined the meaningful benefits that positively align with the concept of sustainability. Overall, the literature findings indicate that the expansion of the roadway energy harvesting technology to a large practical scale is feasible, but such an undertaking should be wisely weighed from broader perspectives. Ultimately, the article provides a positive outlook of the potential contributions of road energy harvesting technologies to the ongoing energy and environmental challenges of human society.
On the Relationship between Intermediate Input Imports and Export Quality in China

This paper studies the connection between intermediate input imports and firms’ export quality using firm‐level data from 2000 to 2007. Our regression results show that intermediate input imports promote manufacturing firms’ export quality through ‘variety effects’ and ‘innovation effects’, though the effects are significantly different among firms with different characteristics, and the magnitude of these effects differs across import sources and the quality of imported intermediate inputs themselves. Moreover, we find that a good institutional environment is conducive to the strengthening of the positive influence of intermediate input imports on export quality. Furthermore, the dynamic decomposition demonstrates that the reallocation effect is the key force through which imported inputs boost industrial aggregate quality growth. Taken together, these results suggest that product upgrading facilitated by quality embedded in imported intermediate inputs, a good institutional environment and market share reallocation help Chinese firms to improve the quality of their export products.
Survey of Archaeal Diversity Reveals an Abundance of Halophilic Archaea in a Low-Salt, Sulfide- and Sulfur-Rich Spring

ABSTRACT The archaeal community in a sulfide- and sulfur-rich spring with a stream water salinity of 0.7 to 1.0% in southwestern Oklahoma was studied by cloning and sequencing of 16S rRNA genes. Two clone libraries were constructed from sediments obtained at the hydrocarbon-exposed source of the spring and the microbial mats underlying the water flowing from the spring source. Analysis of 113 clones from the source library and 65 clones from the mat library revealed that the majority of clones belonged to the kingdom Euryarchaeota, while Crenarchaeota represented less than 10% of clones. Euryarchaeotal clones belonged to the orders Methanomicrobiales, Methanosarcinales, and Halobacteriales, as well as several previously described lineages with no pure-culture representatives. Those within the Halobacteriales represented 36% of the mat library and 4% of the source library. All cultivated members of this order are obligately aerobic halophiles. The majority of halobacterial clones encountered were not affiliated with any of the currently described genera of the family Halobacteriaceae. Measurement of the salinity at various locations at the spring, as well as along vertical gradients, revealed that soils adjacent to spring mats have a much higher salinity (NaCl concentrations as high as 32%) and a lower moisture content than the spring water, presumably due to evaporation. By use of a high-salt-plus-antibiotic medium, several halobacterial isolates were obtained from the microbial mats. Analysis of 16S rRNA genes indicated that all the isolates were members of the genus Haloferax. All isolates obtained grew at a wide range of salt concentrations, ranging from 6% to saturation, and all were able to reduce elemental sulfur to sulfide. We reason that the unexpected abundance of halophilic Archaea in such a low-salt, highly reduced environment could be explained by their relatively low salt requirement, which could be satisfied in specific locations of the shallow spring via evaporation, and their ability to grow under the prevalent anaerobic conditions in the spring, utilizing zero-valent sulfur compounds as electron acceptors. This study demonstrates that members of the Halobacteriales are not restricted to their typical high-salt habitats, and we propose a role for the Halobacteriales in sulfur reduction in natural ecosystems.
Teachers' Reported Beliefs and Feelings About Race Talk

This three-article dissertation addressed a central question: What do teachers describe as their beliefs and feelings about race and teaching, and how can we build practices in teacher education to support them? Considering vast evidence of racial inequities, research has stressed that teachers need a deeper understanding of race and the ways in which schools and society have contributed to racial inequity and injustice. First, through a systematic review of literature on race and teacher education, emergent themes illustrated (a) shifts toward race in teacher education programs, (b) components of a race-related curriculum, and (c) pedagogical practices that center race. Next, two empirical studies drew on data from the Teachers Race Talk Survey. The first study built on the concept of self-efficacy to examine differences in and predictors of teachers’ reported feelings of preparedness to discuss race with students. Hypothesis testing and logistic regression analysis of data from 495 teachers revealed that teachers who had race-focused teacher education programs, taught mostly students of color, and had 10 or more years of experience reported significantly higher feelings of preparedness. Race-focused teacher education programs and perceptions of parental and administrator support were significantly strong predictors of preparedness for race talk. The second study used a Color-blind Racism Framework to analyze how 336 White teachers described their beliefs and feelings about talking with students about race and police violence. Findings demonstrated that many White teachers believe race is important to discuss, but they often opt out of race talks due to fear or to protect their own interests, namely their jobs. Regarding police violence, teachers counter their beliefs about the importance of race through their color-blind approach to understand and explain race. This dissertation found that opportunities to learn about race in teacher education programs are essential for supporting teachers in building race-centered practices. Implications for developing teachers’: racial critical consciousness—race consciousness and knowledge and strategies for engaging in practices that disrupt inequities; connections with parents and administrators; and opportunities for race-engagement are discussed. Potential future research with sub-groups of teachers and approaches for incorporating multiple data perspectives are also considered.
Brief Report: Reduced Cell-Associated HTLV-2 DNA in Antiretroviral Treated HIV-1–HCV-Coinfected Patients Who Either Received Interferon-&agr;/Ribavirin-Based Hepatitis C Therapy or Had Spontaneous HCV RNA Clearance

Abstract:We analyzed the effect of interferon &agr; (IFN-&agr;) and ribavirin (RBV) therapy on cell-associated human T-lymphotropic virus type 2 (HTLV-2) DNA in HIV-1-coinfected patients receiving antiretroviral therapy. Sixty-one patients under suppressive antiretroviral therapy were included: 37 with hepatitis C virus (HCV) infection, 15 with sustained virologic response (N = 10), relapse (N = 2), or with nonresponse (N = 3) after IFN-&agr;/RBV treatment, and 9 with spontaneous HCV RNA clearance. Patients who were treated with IFN-&agr;/RBV or had spontaneous HCV clearance had lower level of cell-associated HTLV-2 DNA (P = 0.022 and P = 0.040, respectively). Both IFN-alpha treatment and the ability to spontaneously clear HCV infection seem to reduce cell-associated HTLV-2 DNA in HIV-1-coinfected patients.
BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction

A proper innate inflammatory response is essential for prevention of the systemic inflammation associated with sepsis. BTLA is an immune‐regulatory receptor demonstrated to be expressed not only on adaptive immune populations and have potent inhibitory effects on CD4+ T cells but is also expressed on innate cell populations (CD11c+ and CD11b+ cells) and has been shown to diminish pathogen clearance following bacterial and parasite infection. The role of BTLA in sepsis and the mechanisms by which BTLA alters pathogen clearance, however, have not been addressed clearly. Here, we show that following acute experimental sepsis induction in mice (CLP), the number of infiltrating BTLA‐ and HVEM (the ligand for BTLA)‐expressing macrophages, inflammatory monocytes, mature and immature DCs, and neutrophils increased in the peritoneum compared with sham surgery, suggesting that a high level of HVEM:BTLA interactions occurs between these cells at the site of septic insult. Given this, we evaluated BTLA−/− mice, 24 h post‐CLP, and observed a marked increase in the degree of activation on these cell populations, as well as a reduction in peritoneal bacterial burden and IL‐10 induction, and most importantly, BTLA−/− mice exhibited a higher rate of survival and protection from organ injury when compared with WT mice. Such changes were not restricted to experimental mice, as circulating BTLA+ and HVEM+ monocytes and HVEM+ granulocytes were increased in septic ICU patients, supporting a role for BTLA and/or HVEM as potential, novel diagnostic markers of innate immune response/status and as therapeutic targets of sepsis.
Trends and Demographics in Anterior Cruciate Ligament Reconstruction in the United States

Abstract The purpose of this study was to identify the trends and demographics of patients undergoing arthroscopic anterior cruciate ligament (ACL) reconstruction in the United States. Patients who underwent arthroscopic ACL reconstruction between 2004 and 2009 were identified by searching Current Procedural Terminology codes in the PearlDiver Patient Record Database (PearlDiver Technologies, Fort Wayne, IN). The year of procedure, age, gender, and region of the United States were recorded for each patient. Associated meniscal procedures and the absence or presence of a femoral nerve block were also recorded. The incidence of ACL reconstruction significantly increased over the study period, from 40.9 cases per 10,000 patients in 2004 to 47.8 in 2009 (p < 0.001). Of these cases, 92.8% were associated with either meniscectomy or meniscal repair. ACL reconstruction was performed most commonly in patients aged 10 to 29 years (p < 0.001). A significant male predominance was observed with an incidence ratio of male-to-female of 2.03 (p < 0.001). The frequency of females undergoing ACL reconstruction as a proportion of the total number of annual cases increased from 2,295 in 2004 to 3,476 in 2009 (p = 0.0031). A significant increase in the annual proportion of ACL reconstruction performed under femoral nerve block was also observed, from 2.0% in 2004 to 8.3% in 2009 (p < 0.001). The greatest incidence of ACL reconstruction occurred in the Western region of the United States. An increase in the rate of arthroscopic ACL reconstruction was observed between 2004 and 2009 and 92.8% of the ACL reconstructions were associated with a meniscal procedure. The majority of cases were performed in patients aged 10 to 29 years, with a male predominance. Increases were observed in the number of female cases and proportion performed under a femoral nerve block. The Western region of the United States was found to have a higher incidence of ACL reconstruction.