Miracle-dz/UniFAR-FTUs huggingface dataset:
QoS-Aware Single Cell Admission Control for UTRAN LTE Uplink

UTRAN Long Term Evolution (LTE) architecture shall support end-to-end quality of service (QoS). To maintain the QoS of in-progress sessions in a cell it is important to admit a new radio bearer only if all the existing sessions and the new bearer can be guaranteed QoS according to their requirements. Hence admission control (AC) has an important role to play for QoS provisioning. In this paper we propose an AC algorithm for LTE uplink utilizing the fractional power control formula agreed in 3GPP. The proposed AC algorithm is compared with a reference AC algorithm. It is shown that at 10% unsatisfied user probability the carried traffic gain of the proposed AC algorithm can be up to around 29% over the reference AC algorithm. Furthermore, the proposed AC algorithm inherently tunes itself for varying load conditions without additional complexity.
Endocrine therapy for male breast cancer: rates of toxicity and adherence.

PURPOSE Most male breast cancer tumours are hormone receptor-positive; the patients therefore receive endocrine therapy. There is, however, a paucity of published data on toxicities experienced by male breast cancer patients who are prescribed endocrine therapy. In the present study, we examined rates of adherence to and toxicity from endocrine treatments in male breast cancer patients treated at a single institution. PATIENTS AND METHODS We conducted a retrospective study of male patients diagnosed with breast cancer at The Ottawa Hospital Cancer Centre during 1981-2003. Data collected included patient age, hormone receptor status, therapy adherence, self-reported toxicities, and type and duration of endocrine therapies. RESULTS The review located 59 cases of early-stage and metastatic male breast cancer. Median patient age was 68.0 years. Tamoxifen was given to 38 patients (64.4%), anastrozole to 8 (13.6%), and letrozole to 5 (8.5%). Of patients who received endocrine therapy, 10 (25%) received adjuvant systemic chemotherapy. Toxicity was reported by 19 patients taking tamoxifen (50%), with hot flashes being the most common complaint (18.4%). Decreased libido, weight gain, and malaise were reported by 5 patients (13.2%). Rash and erectile dysfunction were reported by 3 patients (7.9%). Increased liver enzymes, pulmonary embolism, superficial thrombophlebitis, myalgia, depression, visual blurring, and loose stools were each reported in 1 patient (2.6%). Tamoxifen therapy was discontinued secondary to toxicity in 9 patients (23.7%). Of the patients treated with anastrozole, 3 (37.5%) reported toxicity, with 1 report each of decreased libido, leg swelling, and depression (12.5%). Toxicity was reported in 2 patients taking letrozole (40%), with both reporting peripheral edema, and 1 reporting hot flashes. No patient discontinued anastrozole or letrozole because of toxicity. CONCLUSIONS Few studies specifically report data on adherence to and toxicities from endocrine therapies in male breast cancer patients. The rate of discontinuation at our institution because of toxicity (23.7%) is similar to that reported in the female breast cancer population. Future prospective studies should explore strategies to improve adherence to endocrine therapy in this population.
Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls.

AIM We conducted a systematic review and a meta-analysis, in order to investigate the potential association of cytokine gene polymorphisms with either aggressive or chronic periodontal disease. MATERIAL AND METHODS A comprehensive literature search was performed. We retrieved a total of 53 studies summarizing information about 4178 cases and 4590 controls. Six polymorphisms were included in our meta-analysis which are the following: IL-1A G[4845]T, IL-1A C[-889]T, IL-1B C[3953/4]T, IL-1B T[-511]C, IL-6 G[-174]C and TNFA G[-308]A. Random effect methods were used for the analysis. We calculated the specific odds ratios along with their 95% confidence intervals to compare the distribution of alleles and genotypes between cases and controls. RESULTS AND CONCLUSIONS Using random effect methods we found statistically significant association of IL-1A C[-889]T and IL-1B C[3953/4]T polymorphisms with chronic periodontal disease without any evidence of publication bias or significant statistical heterogeneity. A weak positive association was also found concerning IL-1B T[-511]C and chronic periodontal disease. No association was found for all the cytokines examined as far as the aggressive form of the disease is concerned. Future studies may contribute to the investigation of the potential multigenetic predisposition of the disease and reinforce our findings.
Systematic review of the prevalence of suicidal ideation and behavior in minors who have been sexually abused.

UNLABELLED The experience of sexual abuse in childhood is a serious public health problem that is associated with suicidal behavior in numerous cases. Awareness of the relation between the experience of sexual abuse in childhood with suicidal ideation and behavior in adolescence is relevant in academic and professional terms. METHOD A systematic review was made of published studies on the prevalence of suicide among childhood victims of sexual abuse in the European Union. Studies cited in the PsycINFO, Scopus and MEDLINE Web of Science databases were retrieved using the terms: “sexual abuse” AND “child” AND “suicide” AND “prevalence” OR “incidence”. RESULTS The results obtained from the 16 studies reviewed show a high frequency of suicidal ideation and behavior in these victims and highlight a serious consequence of sexual abuse that seems to affect a significant number of minors. The victims of childhood sexual abuse have a 2- to 3-fold higher risk of suicidal ideation and 3- to 4-fold higher risk of attempted suicide than nonvictims. CONCLUSIONS In the health care field, it is important to understand the specific short-term and long-term effects of childhood sexual abuse, which could improve the effectiveness of intervention in victims and treatment for those at increased risk of suicide.
BONE COMPOSITION AND THE RECONSTRUCTION OF DIET: EXAMPLES FROM THE MIDWESTERN UNITED STATES

Recently employed chemical analytical methods offer a means for measuring past subsistence practices. Carbon isotope analysis and trace element analysis provide in dications of the importance of certain dietary components. The present study deals with the trace element analysis of bone samples from prehistoric sites in Wisconsin. Changes in strontium values through time suggest increasing plant use from the Late Archaic to the Mississippian. Comparison is made with other recent studies of diet.
A prelude to modern science

Part I. Character and Purpose of the Tabulae: 1. The Vesalian problem 2. Advent of the graphic method 3. The art of the Tabulae Part II. Vesalius and the schools of Louvain and Paris: 1. Early years of Vesalius 2. Anatomy at Paris 3. Charles Estienne 4. Vesalius at Paris 5. Vesalius returns to Louvain 6. Anatomical equipment of Vesalius in 1537 Part III. Italian Predecessors of Vesalius: 1. Early Italian Humanist anatomists 2. Early Italian illustrated anatomies 3. Massa (c.1480-1569) Part IV. Galenic Physiology and its Latin Presentation: 1. Basic principle of Galenic physiology 2. The Galenic physiological scheme Part V. Certain Anatomica Elements in the Tabulae: 1. Reliance of Vesalius on animal anatomy 2. Rete mitabile 3. Position and form of the heart 4. Branches of aortic arch 5. Superior vena cava 6. Caval system 7. Posterior intercostal vessels 8. Relative levels of kidneys and of renal vessels 9. Five equal lobes of liver 10. Homologies of generative organs of the two sexes 11. Prostate gland 12. Asymmetry of spermatic veins 13. Seven segments of sternum Part VI. Renaissance Anatomical Vocabulary: 1. General sources of the vocabulary 2. Direct sources of the 'modern' vocabulary 3. Anatomical incunabula 4. Contributions to the vocabulary from Renaissance antomies Part VII. Semitic elements in the Tabulae: 1. Introduction 2. History of Arabic anatomical nomenclature 3. Passage of Arabic anatomical nomenclature to Latin West 4. The Hebrew elements in the Renaissance anatomical vocabulary 5. Did Vesalius know Arabic and Hebrew? 6. General character of Medieval Hebrew 9. Hebraic corruptions in the Tabulae 10. General character of the Arabic vocabulary in the Tabulae 11. Hebraized Romace terms in the Tabulae Part VIII. Translation and Commentary Part IX. General Index Part X. Greek Index Part XI. Arabic Index Part XXII. Hebrew index Plates.
The Emerging Role of the Gut Microbiome in Adult Patients With Multiple Sclerosis

ABSTRACT Background: Approximately 2.3 million people worldwide are currently living with multiple sclerosis (MS). The pathophysiologic mechanism of MS is not well known. It has been suggested that alterations in the normal gut flora may contribute to MS etiology and symptoms. Objective: The aims of this review are to describe the data suggesting a role for the gut microbiome in MS research and address its implications for practice. Methods: A literature search of the following databases (PubMed, CINAHL, Cochrane library database, MEDLINE, Scopus, and Psychology and Behavioral Sciences) was conducted to find published studies relevant to gut microbiome in patients with MS. Study Selection: Five articles met the inclusion criteria of research studies of human gut microbiome in adults in English language and those receiving disease-modifying medications. Exclusion criteria were case reports and reviews. Results: Human studies found that the gut microbiome was different among patients with MS, patients with MS who were treated with glatiramer acetate, and healthy controls. Discussion: There is beginning evidence to suggest that the gut microbiota is related to autoimmunity and the pathology of MS. However, more research is necessary to clarify these mechanisms. Implications for Practice: A better understanding of the role of the gut microbiota in MS may lead to the development of targeted individualized interventions affecting the gut microbiota. These interventions may emphasize symptom self-management strategies such as diet.
Experimental investigation of the conduction phase of the microsecond plasma opening switch

Results of experimental studies of the conduction phase of the microsecond plasma opening switch are presented. It is shown that during this phase, translation of the current channel in the plasma near the anode takes place with anomalously high velocity. The ion component of the current reaches 25-30% of the total value, and the current streamlines late in the conduction phase acquire a considerable slant in the axial direction. The ion current behind the current channel makes up more than 30% of the total current there. The ion current density reaches a maximum during the conduction phase and decreases slowly during switching. >
Chronic Obstructive Pulmonary Diseases : Journal of the COPD Foundation Correlation Between Emphysema and Lung Function in Healthy Smokers and Smokers With COPD

Background: Emphysema is an important component of COPD; however, in previous studies the correlation between airflow limitation (AFL) and computed tomography (CT) lung density as a surrogate for emphysema has varied. We hypothesised a good correlation between lung function (forced expiratory volume in first second [FEV1]) and emphysema (15th percentile density [PD15]) and that this correlation also exists between loss of lung tissue and decline in lung function even within the time frame of longitudinal studies of relatively short duration. Methods: We combined 2 large longitudinal studies (the Danish Lung Cancer Screening Trial [DLCST] and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints [ECLIPSE]) of smokers or former smokers, with a wide range of AFL and CT lung density, and analysed data from 2148 participants who did not change smoking habits and who had at least 2 CT scans and 2 FEV1 measurements at least 3 years apart. Results: Baseline correlation between FEV1 and PD15 was high (r=0.716, 95% confidence interval [CI]: 0.6940.736, p<0.001) indicating that at least half of the variation in FEV1 can be explained by variation in CT lung density. Correlation between the decline in FEV1 and progression of PD15 was considerably weaker (r=0.081, 95% CI: 0.038-0.122, p<0.001). Conclusions: Correlation is very high between lung density and lung function in a broad spectrum of smokers and ex-smokers. In contrast, the temporal associations (slopes) are weakly correlated, probably due to uncertainty in the estimation of slopes within a time frame of 3-4 years. Abstract
Self-Organized Supercriticality and Oscillations in Networks of Stochastic Spiking Neurons

Networks of stochastic spiking neurons are interesting models in the area of Theoretical Neuroscience, presenting both continuous and discontinuous phase transitions. Here we study fully connected networks analytically, numerically and by computational simulations. The neurons have dynamic gains that enable the network to converge to a stationary slightly supercritical state (self-organized supercriticality or SOSC) in the presence of the continuous transition. We show that SOSC, which presents power laws for neuronal avalanches plus some large events, is robust as a function of the main parameter of the neuronal gain dynamics. We discuss the possible applications of the idea of SOSC to biological phenomena like epilepsy and dragon king avalanches. We also find that neuronal gains can produce collective oscillations that coexists with neuronal avalanches, with frequencies compatible with characteristic brain rhythms.
Survival of patients identified as candidates for intestinal transplantation: a 3-year prospective follow-up.

BACKGROUND & AIMS The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated the appropriateness of these indications. METHODS Survival on home parenteral nutrition or after transplantation was analyzed in 153 (97 adult, 56 pediatric) candidates for transplantation and 320 (262 adult, 58 pediatric) noncandidates, enrolled through a European multicenter cross-sectional survey performed in 2004. Kaplan-Meier and chi-square test statistics were used. RESULTS The 3-year survival was 94% (95% CI, 92%-97%) in noncandidates and 87% (95% CI, 81%-93%) in candidates not receiving transplants (P = .007). Survival was 80% (95% CI, 70%-89%), 93% (95% CI, 86%-100%), and 100% in parenteral nutrition failure, high-risk primary disease, and high-morbidity intestinal failure, respectively (P = .034). Fifteen candidates underwent transplantation. Six died, including all 3 of those who were in hospital, and 25% of those who were at home at time of transplantation (P = .086). Survival in the 10 patients receiving a first isolated small bowel transplant was 89% (95% CI, 70%-100%), compared with 85% (95% CI, 74%-96%) in the candidates with parenteral nutrition failure not receiving transplants because of central venous catheter complications, or 70% (95% CI, 53%-88%) in those with parenteral nutrition-related liver failure (P = .364). CONCLUSIONS The results confirm home parenteral nutrition as the primary therapeutic option for intestinal failure and support the appropriateness and potential life-saving role of timely intestinal transplantation for patients with parenteral nutrition failure.
Excitation and desensitization of mouse rod photoreceptors in vivo following bright adapting light

Electroretinographic (ERG) methods were used to determine response properties of mouse rod photoreceptors in vivo following adapting illumination that produced a significant extent of rhodopsin bleaching. Bleaching levels prevailing at ∼10 min and ∼20 min after the adapting exposure were on average 14% and 9%, respectively, based on the analysis of visual cycle retinoids in the eye tissues. Recovery of the rod response to the adapting light was monitored by analysing the ERG a‐wave response to a bright probe flash presented at varying times during dark adaptation. A paired‐flash procedure, in which the probe flash was presented at defined times after a weak test flash of fixed strength, was used to determine sensitivity of the rod response to the test flash. Recovery of the response to the adapting light was 80% complete at 13.5 ± 3.0 min (mean ±s.d.; n= 7) after adapting light offset. The adapting light caused prolonged desensitization of the weak‐flash response derived from paired‐flash data. By comparison with results obtained in the absence of the adapting exposure, desensitization determined with a test‐probe interval of 80 ms was ∼fourfold after 5 min of dark adaptation and ∼twofold after 20 min. The results indicate, for mouse rods in vivo, that the time scale for recovery of weak‐flash sensitivity substantially exceeds that for the recovery of circulating current following significant rhodopsin bleaching. The lingering desensitization may reflect a reduced efficiency of signal transmission in the phototransduction cascade distinct from that due to residual excitation.
Acoustic cues to perception of word stress by English, Mandarin, and Russian speakers.

PURPOSE This study investigated how listeners' native language affects their weighting of acoustic cues (such as vowel quality, pitch, duration, and intensity) in the perception of contrastive word stress. METHOD Native speakers (N = 45) of typologically diverse languages (English, Russian, and Mandarin) performed a stress identification task on nonce disyllabic words with fully crossed combinations of each of the 4 cues in both syllables. RESULTS The results revealed that although the vowel quality cue was the strongest cue for all groups of listeners, pitch was the second strongest cue for the English and the Mandarin listeners but was virtually disregarded by the Russian listeners. Duration and intensity cues were used by the Russian listeners to a significantly greater extent compared with the English and Mandarin participants. Compared with when cues were noncontrastive across syllables, cues were stronger when they were in the iambic contour than when they were in the trochaic contour. CONCLUSIONS Although both English and Russian are stress languages and Mandarin is a tonal language, stress perception performance of the Mandarin listeners but not of the Russian listeners is more similar to that of the native English listeners, both in terms of weighting of the acoustic cues and the cues' relative strength in different word positions. The findings suggest that tuning of second-language prosodic perceptions is not entirely predictable by prosodic similarities across languages.
The importance of understanding individual differences in Down syndrome

In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences at every level of description. We argue that, in the context of significant increases in DS life expectancy, a focus on individual differences in trisomy 21 at all levels—genetic, cellular, neural, cognitive, behavioral, and environmental—constitutes one of the best approaches for understanding genotype/phenotype relations in DS and for exploring risk and protective factors for Alzheimer’s disease in this high-risk population.
Moral disengagement among children and youth: a meta-analytic review of links to aggressive behavior.

A growing body of research has demonstrated consistent links between Bandura's theory of moral disengagement and aggressive behavior in adults. The present meta-analysis was conducted to summarize the existing literature on the relation between moral disengagement and different types of aggressive behavior among school-age children and adolescents. Twenty-seven independent samples with a total of 17,776 participants (aged 8-18 years) were included in the meta-analysis. Results indicated a positive overall effect (r = .28, 95% CI [.23, .32]), supporting the hypothesis that moral disengagement is a significant correlate of aggressive behavior among children and youth. Analyses of a priori moderators revealed that effect sizes were larger for adolescents as compared to children, for studies that used a revised version of the original Bandura scale, and for studies with shared method variance. Effect sizes did not vary as a function of type of aggressive behavior, gender, or publication status. Results are discussed within the extant literature on moral disengagement and future directions are proposed.
Ebola and Indirect Effects on Health Service Function in Sierra Leone

Background: The indirect effects of the Ebola epidemic on health service function may be significant but is not known. The aim of this study was to quantify to what extent admission rates and surgery has changed at health facilities providing such care in Sierra Leone during the time of the Ebola epidemic. Methods: Weekly data on facility inpatient admissions and surgery from admission and surgical theatre register books were retrospectively retrieved during September and October. 21 Community Health Officers enrolled in a surgical task-shifting program personally visited the facilities. The study period was January 6 (week 2) to October 12, (week 41) 2014. Results: Data was retrieved from 40 out of 55 facilities. A total of 62,257 admissions and 12,124 major surgeries were registered for the study period. Total admissions in the week of the first Ebola case were 2,006, median 40 (IQR 20-76) compared to 883, median 12 (IQR 4-30) on the last week of the study. This equals a 70% drop in median number of admissions (p=0.005) between May and October. Total number of major surgeries fell from 342, median 6 (IQR 2-14) to 231, median 3 (IQR 0-6) in the same period, equal 50% reduction in median number of major surgeries (p=0.014). Conclusions: Inpatient health services have been severely affected by the Ebola outbreak. The dramatic documented decline in facility inpatient admissions and major surgery is likely to be an underestimation. Reestablishing such care is urgent and must be a priority.
The Occupational History of Galindo, Moche Valley, Peru

Abstract The archaeological site of Galindo, located in the Moche Valley, is one of the most important Late Moche (ca. A. D. 600—800) centers on the North Coast of Peru. The site was once thought to have been occupied only after the nearby Huacas de Moche, the paramount Middle Moche (ca. A. D. 300–600) center in the valley, was abandoned. Recent radiocarbon dates from the Huacas de Moche, however, indicate that it continued to be occupied well into the eighth century A. D. This paper presents data on the occupational history of Galindo recently obtained during the Galindo Archaeological Project (GAP). These data, along with similar data from the Huacas de Moche, present a new understanding of the occupational history of the Moche Valley during the first half of the Middle Horizon (A.D. 600–1000).