Miracle-dz/UniFAR-FTUs huggingface dataset:
A 33W GaN HEMT Doherty amplifier with 55% drain efficiency for 2.6GHz base stations

A 33W average output power Doherty power amplifier (PA) for 2.6GHz band was developed using compact package advanced GaN HEMTs which have Cds reduced 20%. A small-footprint Doherty network was successfully designed with plain small signal analysis, and the method was very practical. The Doherty PA exhibited a saturation output power of 52.5dBm (178W) and a saturated drain efficiency of 65.6%. The Doherty PA also achieved a drain efficiency of 55%, an ACLR of −52.8dBc and a power gain of 13.8dB at the average output power of 45.2dBm (33W) with 4-carrier W-CDMA signal at 2.6GHz using commercially available digital pre-distortion system. These excellent performances show good suitability for 2.6GHz band basestations (BTS), for example, W-CDMA, LTE and WiMAX, and small-sized circuit structure contributes to realize compact remote radio head type of BTS.
Normal Reproductive Function in InhBP/p120-Deficient Mice

ABSTRACT The inhibins are gonadal transforming growth factor β superfamily protein hormones that suppress pituitary follicle-stimulating hormone (FSH) synthesis. Recently, betaglycan and inhibin binding protein (InhBP/p120, also known as the product of immunoglobulin superfamily gene 1 [IGSF1]) were identified as candidate inhibin coreceptors, shedding light on the molecular basis of how inhibins may affect target cells. Activins, which are structurally related to the inhibins, act within the pituitary to stimulate FSH production. Betaglycan increases the affinity of inhibins for the activin type IIA (ACVR2) receptor, thereby blocking activin binding and signaling through this receptor. InhBP/p120 may not directly bind inhibins but may interact with the activin type IB receptor, ALK4, and participate in inhibin B's antagonism of activin signaling. To better understand the in vivo functions of InhBP/p120, we characterized the InhBP/p120 mRNAs and gene in mice and generated InhBP/p120 mutant mice by gene targeting in embryonic stem cells. InhBP/p120 mutant male and female mice were viable and fertile. Moreover, they showed no alterations in FSH synthesis or secretion or in ovarian or testicular function. These data contribute to a growing body of evidence indicating that InhBP/p120 does not play an essential role in inhibin biology.
Elicitation non-paramétrique de la fonction d'utilité et de l'aversion aux pertes sous l'hypothèse "prospect theory"

Dans ce travail, les fonctions d'utilite des gerants de portefeuilles sont elicitees et leurs degres d'aversion aux pertes mesures sous l'hypothese de la theorie des prospects (1992) et suivant la methode non-parametrique d'Abdellaoui et al. (2006). Les resultats obtenus sur le terrain corroborent les resultats obtenus par ces derniers au laboratoire quant a la concavite de la fonction d'utilite pour les gains et la convexite pour les pertes. En ce qui concerne l'aversion aux pertes, nos observations confirment son existence; neanmoins, le gerant de portefeuilles median est moins averse aux pertes que l'etudiant median. Les conditions qui caracterisent une experience reelle du marche mais qui sont difficiles a reproduire dans le contexte artificiel du laboratoire pourraient expliquer les differences de comportement: notamment, la volatilite du marche boursier, les compensations incitatives de Wall Street et le fait que les gerants de portefeuilles acquierent sur le terrain une gamme de formation et un haut niveau de connaissance qui font qu'ils evaluent les enjeux differenmment des etudiants. La fonction d'utilite doit neanmoins, refleter les preferences de l'individu et l'utilite ne doit pas changer selon la methode utilisee. En effet, l'etude qualitative des preferences d'etudiants en MBA suivant la methode non-parametrique de Baucells et Heukamp (2006) confirme les resultats d'Abdellaoui et al. (2006) pour etudiants. Il est a noter cependant que les etudiants changent de preference (ne sont plus averses aux pertes mais recherchent le gain) quand l'une des deux loteries offre une plus grande probabilite globale de gain ou une plus grande probabilite de gain maximal combinee avec une perte extreme limitee.
Energetics of glycerol conduction through aquaglyceroporin GlpF

Aquaglyceroporin GlpF selectively conducts water and linear polyalcohols, such as glycerol, across the inner membrane of Escherichia coli. We report steered molecular dynamics simulations of glycerol conduction through GlpF, in which external forces accelerate the transchannel conduction in a manner that preserves the intrinsic conduction mechanism. The simulations reveal channel-glycerol hydrogen bonding interactions and the stereoselectivity of the channel. Employing Jarzynski's identity between free energy and irreversible work, we reconstruct the potential of mean force along the conduction pathway through a time series analysis of molecular dynamics trajectories. This potential locates binding sites and barriers inside the channel; it also reveals a low energy periplasmic vestibule suited for efficient uptake of glycerol from the environment.
Frequency drift reduction through alternating magnetic field between coupled resonators in power transfer systems

In order to reduce the impact of frequency drift, a new technique taking advantage of the strong alternating magnetic field between strongly coupled resonators in power transfer systems is proposed. Through these resonators with high quality factors, highly efficient power transmission is achievable. This paper focuses on exploiting the oscillator state information hidden in mutual strong alternating magnetic field for power transfer to reduce the cost for communication devices and acquire higher robustness against frequency drift. Comparison is made between our system and the typical phase shift-keying (PSK) systems with phase-locked loop and pilots in terms of bit error rate (BER). Simulation results illustrate lower BER and higher stability can be achieved by the proposed systems, especially when the frequencies of oscillators are unstable due to ambient temperature fluctuation.
Effects of positive reinforcement training techniques on the psychological welfare of zoo‐housed chimpanzees (Pan troglodytes)

Captive environments encompass various factors that can elevate stress levels and jeopardize the wellbeing of the captive animals. The use of positive reinforcement training (PRT) techniques enables researchers and caretakers to reduce tension directly associated with potentially stressful procedures and states. The current study tested the general effect of PRT on the wellbeing of zoo‐housed chimpanzees (Pan troglodytes) by measuring behaviors that reflect poor and good welfare and that were not directly connected to the specific aim of the training session. The behavior of a group of twelve chimpanzees was measured throughout the day from the exhibition yard, at baseline (12 weeks) and during the PRT period (10 weeks). The results show a significant decrease in abnormal and stress‐related behaviors and a significant rise in prosocial affiliative behaviors following implementation of the training program. The training was shown to have a greater positive effect on low‐ranking individuals compared with high‐ranking ones. This research shows for the first time that PRT offers an enrichment effect whose general influence lasts throughout the day, irrespective of any direct link to a specific trained behavior. Consequently, it can be claimed that PRT presents an effective enrichment tool that can be implemented with captive animals. Because of the above‐noted differential effect between high‐ and low‐ranking chimpanzees, however, this should be taken into consideration when combining PRT with the non‐human primates' daily routine. Am. J. Primatol. 71:687–695, 2009. © 2009 Wiley‐Liss, Inc.
Activation peptide of carboxypeptidase B and anionic trypsinogen as early predictors of the severity of acute pancreatitis

Early prediction of severity is important in the management of patients with acute pancreatitis. The presence of activation peptides and certain pancreatic proenzymes in plasma and urine has been shown to correlate with severity. This study was designed to assess the value of measuring levels of the activation peptide of carboxypeptidase B (CAPAP) and of anionic trypsinogen.
Evaluation of functional impairment in psoriasis.

BACKGROUND Psoriasis is a chronic disease, the course of which is punctuated by exacerbations and remissions. The impact of a chronic, relapsing, and disfiguring disease such as psoriasis on occupational, social, and other areas of functioning is substantial and needs attention. AIM The purpose of this study was to assess the level and nature of functional impairment in psoriasis. METHODS Forty-three consecutive patients attending the dermatology clinic of a rural hospital were studied for psychiatric comorbidity and the level of functioning, using a semistructured questionnaire. RESULTS Psoriasis affected social functioning of 48% patients, led to decreased work efficiency in 51.1% and to subjective distress at work in 62.8% of patients. Stress in home environment and interpersonal relationships was reported by 69.8%. Social and occupational functioning worsened with increasing severity of psoriasis after 1-year duration of illness. Patients complaining of pruritus frequently had anxiety disorders. Psychiatric comorbidity was detected in 67.4% cases. CONCLUSION Substantial proportion of patients suffered deterioration of functioning, especially with increasing duration of illness. Thus, timely attention by dermatologists is needed in order to limit the disability caused by psoriasis. To achieve this, liaison with psychiatrist would be crucial along with illness education and emotional support.
Psychological and physical pain as predictors of suicide risk: evidence from clinical and neuroimaging findings

Purpose of review Suicide is a multidimensional clinical phenomenon with complex biological, social and psychological risk factors. Therefore, it is imperative for studies to focus on developing a unified understanding of suicide risk that integrates current clinical and neurobiological findings. A recent line of research has implicated different classifications of pain in understanding suicide risk, including the concepts of psychache and pain tolerance. Although psychache is defined as the experience of unbearable psychological pain, pain tolerance refers to the greatest duration or intensity of painful stimuli that one is able to bear. This review will focus on integrating current clinical and neurobiological findings by which psychache and pain tolerance confer suicide risk. Recent findings Results indicate that psychache has been identified as a significant risk factor for suicide and that psychache may be associated with the neurocircuitry involved in the modulation of physical pain. Converging evidence has also been found linking pain tolerance to self-injurious behaviours and suicide risk. The experience of psychache and physical pain in relation to other predictors of suicide, including reward processing, hopelessness and depression, are further discussed. Summary Future research examining the pain-suicide connection is required to understand the mechanism behind clinically relevant risk factors for suicide, which can ultimately inform the construction of empirically supported suicide risk assessment and intervention techniques.
Electrical, optical, and magnetic properties of poly(2,5-diethoxy-p-phenylene vinylene).

L'evolution des etats localises est mise en evidence par le changement spectral avec le dopage electrochimique. La bande interdite est evaluee a environ 2,2 eV. La susceptibilite de spin augmente d'environ un facteur 1000 avec la concentration du dopant jusqu'a 2,2% en mole puis elle diminue legerement. La largeur de raie en RPE est minimale a cette meme concentration. Le dopage entraine une diminution du facteur g
Noninvasive hemoglobin measurement in pediatric trauma patients

INTRODUCTION Hemorrhage is a major cause of preventable death secondary to traumatic injury. Diagnosis often requires multiple blood draws, which are psychologically stressful in pediatric patients. The Pronto device is a pulse co-oximeter that measures the total hemoglobin level using multiple wavelengths of light. The purpose of this study was to evaluate the accuracy of the noninvasive hemoglobin measurements relative to current invasive and point of care testing methods in pediatric trauma patients. METHODS We performed a prospective observational trial involving patients younger than 17 years presenting to a Level I pediatric trauma center. Following admission, blood was sampled from each patient for testing using an i-Stat device (point-of-care hemoglobin) and a complete blood count within our core laboratory (invasive hemoglobin). Noninvasive hemoglobin analysis was performed within 15 minutes of phlebotomy. Data were evaluated using Spearman correlation and Bland-Altman analysis. RESULTS Over 2 years, 114 patients had attempted noninvasive hemoglobin measurements, with a success rate of 89%. Mean ± SD age was 9.2 ± 5.1 years. Ninety percent of admissions were for blunt injury, 3% penetrating, 5% near drowning, and 1% burns. Mean invasive hemoglobin was 12.6 ± 1.9 g/dL, mean point-of-care hemoglobin was 12.2 ± 2.0 g/dL, and mean noninvasive hemoglobin was 12.3 ± 1.6 g/dL. Noninvasive hemoglobin values were strongly correlated with both invasive and point of care measurements (R = 0.672 and R = 0.645, respectively; p < 0.001). Bland-Altman analysis comparing noninvasive to point-of-care and invasive hemoglobin levels resulted in an estimated bias of −0.39 and −0.49, respectively. CONCLUSION Noninvasive hemoglobin values had excellent correlation with both invasive and point-of-care hemoglobin measurements, although the device was not successful for all patients. Given the rapid availability of results and the lack of requirement of venipuncture, noninvasive hemoglobin monitoring may be a valuable adjunct in the initial evaluation and monitoring of pediatric trauma patients. LEVEL OF EVIDENCE Diagnostic test study, level II.
Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase in the Human Kidney

The secosteroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) plays a vital role in calcium metabolism, tissue differentiation, and normal bone growth. Biosynthesis of 1,25(OH)2D3 is catalyzed by the mitochondrial cytochrome P450 enzyme 25-hydroxyvitamin D3 1alpha-hydroxylase (1alpha-hydroxylase). Although activity of this enzyme has been described in several tissues, the kidneys are recognized to be the principal site of 1,25(OH)2D3 production. To date, enzyme activity studies using vitamin D-deficient animals have suggested that 1alpha-hydroxylase is expressed exclusively in proximal convoluted tubules. With the recent cloning of 1alpha-hydroxylase, specific cRNA probes and in-house polyclonal antiserum have been used to determine the distribution of 1alpha-hydroxylase along the human nephron. Immunohistochemistry and in situ hybridization studies indicated strong expression of 1alpha-hydroxylase protein and mRNA in the distal convoluted tubule, the cortical and medullary part of the collecting ducts, and the papillary epithelia. Lower expression was observed along the thick ascending limb of the loop of Henle and Bowman's capsule. Weaker and more variable expression of 1alpha-hydroxylase protein and mRNA was seen in proximal convoluted tubules, and no expression was observed in glomeruli or vascular structures. These data show for the first time the distribution of alpha1-hydroxylase expression in normal human kidney. In contrast to earlier enzyme activity studies conducted in vitamin D-deficient animals, our data indicate that the distal nephron is the predominant site of 1alpha-hydroxylase expression under conditions of vitamin D sufficiency.
Cytokine Genotyping (TNF and IL-10) in Patients With Celiac Disease and Selective IgA Deficiency

OBJECTIVE:Selective IgA deficiency (IgAD) and celiac disease (CD) are frequently associated and share the ancestral haplotype human leukocyte antigen (HLA)-8.1, which is characterized by a peculiar cytokine profile. The aim of this study was to evaluate the role of tumor necrosis factor (TNF) and interleukin (IL)-10 alleles in CD and CD-IgAD.METHODS:The distribution of some biallelic polymorphisms of both cytokine promoters (−308G→A and −863C→A at TNF promoter sequence and −1082G→A, −819C→A, and −592C→T at IL-10 promoter) were typed using biotilinated specific probes in 32 celiac patients, in 34 CD-IgAD patients, and in 96 healthy controls.RESULTS:In CD and CD-IgAD, the −308A allele was significantly more frequent than in controls, whereas no significant differences were observed for the biallelic polymorphisms at the −863 and for the three IL-10 promoter polymorphisms. The evaluation of combined TNF and IL-10 genotypes showed in CD-IgAD a significant reduction of −308G/−1082G homozygous subjects and both in CD and CD-IgAD groups an increase of 308AA/1082GG. Accordingly, CD-IgAD patients positive both for −308A TNF and −1082A IL-10 showed an increase of TNF-α and a reduction of IL-10 serum levels.CONCLUSIONS:Genetically determined increased production of TNF-α and reduction of IL-10 may be relevant for susceptibility to CD, mainly in IgAD, as the different allele expression at TNF and IL-10 loci seems to influence cytokine production profile.
The Effect of E-Service Quality on E-Trust and E-Satisfaction as Key Factors Influencing Creation of E-Loyalty in E-Business Context: The Moderating Role of Situational Factors

Development of loyalty in customers is a strategic goal of many firms and organizations and today, the main effort of many firms is allocated to retain customers and obtaining even more ones. Characteristics of loyal customers and method for formation of loyalty in customers in internet space are different to those in traditional one in some respects and study of them may be beneficial in improving performance of firms, organizations and shops involving in this field of business. Also it may help managers of these types of businesses to make efficient and effective decisions towards success of their organizations. Thus, present study aims to investigate the effects of e-service quality in three aspects of information, system and web-service on e-trust and e-satisfaction as key factors influencing creation of e-loyalty of Iranian customers in e-business context; Also it was tried to demonstrate moderating effect of situational factors e.g. time poverty, geographic distance, physical immobility and lack of transportation on e-loyalty level. Totally, 400 questionnaires were distributed to university students, that 382 questionnaires were used for the final analysis, which the results from analysis of them based on simple linear regression and multiple hierarchical regression show that customer loyalty to e-shops is directly influenced by e-trust in and e-satisfaction with e-shops which in turn are determined by e-service quality; also the obtained results shows that situational variables can moderate relationship between e-trust and/or e-satisfaction and e-loyalty. Therefore situational variables studied in present research can influence initiation of transaction of customer with online retailer and customer attitude importance and this in turn makes it necessary for managers to pay special attention to situational effects in examination of current attitude and behavior of customers.
Petrological Constraints on Crystallization Conditions of Mesoarchean Sanukitoid Rocks, Southeastern Amazonian Craton, Brazil

We report petrological and geochemical data for the 2*87 Ga Rio Maria sanukitoid granodiorite and associated rocks from Mesoarchean granite-greenstone terranes of the eastern Amazonian craton, Brazil. The dominant rocks have granodiorite to subordinate monzogranitic compositions, with minor proportions of intermediate quartz diorites or quartz monzodiorites, in addition to mafic endmembers occurring as layered rocks or as enclaves. The mineral assemblage is dominated by amphibole-plagioclase-biotite and epidote minerals, all of inferred magmatic origin, pyroxenes being notably absent. Textural and compositional criteria indicate that amphibole is a principal mineral on the liquidus of all the Rio Maria rocks. Crystallization conditions have been derived from a comparison between natural phase assemblages, proportions and compositions and experimental studies carried out on similar magma compositions. The comparison shows that the parental magmas were water-rich, with more than 7 wt % dissolved H2O, with crystallization temperatures in the range 950-680°C. The Mg/(Mg + Fe) ratios of both amphibole and biotite indicate fO2 conditions in the range NNO + 0*5 to NNO + 2*5 (where NNO is nickel-nickel oxide buffer), therefore pointing to both water-rich and oxidizing conditions for sanukitoid magmas. Amphibole compositions indicate emplacement at around 200 MPa, and record a high-pressure stage of magma crystallization around 600-900 MPa. Sanukitoid magmas share two of the principal characteristics of modern arc magmas, elevated redox state and volatile contents, which suggest that they may have formed in a geodynamic environment broadly similar to present-day subduction zones.
Effect of 2 Soccer Matches in a Week on Physical Performance and Injury Rate

Background: Recovery duration may be too short during the congested fixtures of professional soccer players with regard to maintaining physical performance and a low injury rate. Purpose: To analyze the effects of 2 matches per week on physical performance and injury rate in male elite soccer players. Study Design: Cohort study; Level of evidence, 3. Methods: Match results, match-related physical performance, and injuries were monitored during 2 seasons (2007–2008 and 2008–2009) for 32 professional soccer players in a top-level team participating in the UEFA (Union of European Football Associations) Champions League. Total distance, high-intensity distance, sprint distance, and number of sprints were collected for 52 home matches. Injuries and player participation in matches and training were recorded throughout the full season. Results: Physical performance, as characterized by total distance covered, high-intensity distance, sprint distance, and number of sprints, was not significantly affected by the number of matches per week (1 versus 2), whereas the injury rate was significantly higher when players played 2 matches per week versus 1 match per week (25.6 versus 4.1 injuries per 1000 hours of exposure; P < .001). Conclusion: The recovery time between 2 matches, 72 to 96 hours, appears sufficient to maintain the level of physical performance tested but is not long enough to maintain a low injury rate. The present data highlight the need for player rotation and for improved recovery strategies to maintain a low injury rate among athletes during periods with congested match fixtures.