Miracle-dz/UniFAR-FTUs huggingface dataset:
Minor salivary glands and labial mucous membrane graft in the treatment of severe symblepharon and dry eye in patients with Stevens–Johnson syndrome

Objective To evaluate minor salivary glands and labial mucous membrane graft in patients with severe symblepharon and dry eye secondary to Stevens–Johnson syndrome (SJS). Methods A prospective, non-comparative, interventional case series of 19 patients with severe symblepharon and dry eye secondary to SJS who underwent labial mucous membrane and minor salivary glands transplantation. A complete ophthalmic examination including the Schirmer I test was performed prior to and following surgery. All patients had a preoperative Schirmer I test value of zero. Results Nineteen patients with severe symblepharon and dry eye secondary to SJS were included in the study. There was a statistically significant improvement in the best spectacle-corrected visual acuity in eight patients (t test; p=0.0070). Values obtained in the Schirmer I test improved significantly in 14 eyes (73.7%) 6 months following surgery (χ2 test; p=0.0094). A statistically significant increase in tear production (Schirmer I test) was found in eyes that received more than 10 glands per graft compared with eyes that received fewer glands (χ2 test; p=0.0096). Corneal transparency improved significantly in 11 (72.2%) eyes and corneal neovascularisation improved significantly in five eyes (29.4%) (McNemar test; p=0.001 and p=0.0005). The symptoms questionnaire revealed improvement in foreign body sensation in 53.6% of the patients, in photophobia in 50.2% and in pain in 54.8% (Kruskal–Wallis test; p=0.0167). Conclusion Labial mucous membrane and minor salivary glands transplantation were found to constitute a good option for the treatment of severe symblepharon and dry eye secondary to SJS. This may be considered as a step prior to limbal stem cell and corneal transplantation in these patients.
The Unfolded Protein Response Is a Major Mechanism by Which LRP1 Regulates Schwann Cell Survival after Injury

In peripheral nerve injury, Schwann cells (SCs) must survive to exert a continuing and essential role in successful nerve regeneration. Herein, we show that peripheral nerve injury is associated with activation of endoplasmic reticulum (ER) stress and the adaptive unfolded protein response (UPR). The UPR culminates in expression of C/EBP homology protein (CHOP), a proapoptotic transcription factor in SCs, unless counteracted by LDL receptor-related protein-1 (LRP1), which serves as a major activator of phosphatidylinositol 3-kinase (PI3K). Sciatic nerve crush injury in rats induced expression of the ER chaperone GRP78/BIP, reflecting an early, corrective phase of the UPR. However, when LRP1 signaling was inhibited with receptor-associated protein, PI3K activity was decreased and CHOP protein expression increased, particularly in myelinating SCs. In cultured SCs, the PKR-like ER kinase target eIF2α was phosphorylated and CHOP was induced by (1) inhibiting PI3K, (2) treating the cells with tumor necrosis factor-α (TNF-α), or (3) genetic silencing of LRP1. CHOP gene deletion in SCs decreased cell death in response to TNF-α. Furthermore, the effects of TNF-α on phosphorylated eIF2α, CHOP, and SC death were blocked by adding LRP1 ligands that augment LRP1-dependent cell signaling to PI3K. Collectively, our results support a model in which UPR-activated signaling pathways represent a major challenge to SC survival in nerve injury. LRP1 functions as a potent activator of PI3K in SCs and, by this mechanism, limits SC apoptosis resulting from increased CHOP expression in nerve injury.
The Model of Market Orientation, Entrepreneurial Orientation and Business Performance of Small and Medium Enterprises

Small and medium business in Indonesia has different characteristics with other countries. This research aims to analyze the influence between the orientation of the market and the business performance of small and medium enterprises. Entrepreneurial orientation variables used as the antecedent of market orientation and business performance as of the variable consequences. Design research using the survey sample and FGD with owners of small and medium enterprises as the respondent. By using SEM analysis found that entrepreneurial orientation effect directly against the performance of the business, but the orientation of the market does not have significant influence on performance of the business.
Untersuchungen über Fichtengallenläuse, Dreyfusia spp. (Hom., Adelgidae) und deren Predatoren in der Nord-Türkei

In the East Pontic mountains at Giresun (Black Sea shore) three species of the genus Dreyfusia have been established: D. nordmannianae Eckst. and D. prelli Grosm. on Abies nordmanniana Link. and Picea orientalis Link. and Dreyfusia nov. spec. on A. nordmanniana. The latter species, earlier known from Greece and the Balkans, but not yet described is most probably unholocyctic on fir.In the Zigana mountains between Trabzon and Gümüsane a species producing plenty galls on young P. orientalis trees and closely resembling D. merkeri Eichh. has been observed. Further investigations are necessary to evaluate whether or not it lives unholocyclic on spruce.In the West Pontic mountains near Bolu D. nordmannianae was intensively studied in twig infestations on A. bornmülleriana Mattf. The pattern of attack differs greatly from the one experienced in central Europe in that almost exclusively the current year's shoots are attacked whereas the leader and the older twig axis remain free of attack. In Europe all parts of the trees are colonized.Considering the known facts about generation- and morph sequences, morph determination and phenological behaviour of D. nordmannianae the characteristics of their population dynamics in Turkey and the interactions of the curious mode of attack and the extraordinary efficiency of their special predators have been completely evaluated.
Food safety regulatory requirements with potentialeffect on exports of aquaculture products fromdeveloping countries to the EU and US

Aquaculture production presents unique sources of food safety hazards in addition to those common to fish and fishery products and general food stuffs. Hence, its products attract stricter controls in international trade especially in the markets within industrial countries like in the European Union (EU) and the United States (US). Environmental chemical and microbial contamination of fish culture containments, fish infection and disease, use of veterinary drugs, improper use of chemicals, use of genetically modified organisms (GMOs), and improper husbandry and hygiene practices are the major sources of food safety challenges in aquaculture. Most food safety legislations applied in major prime markets of fish like EU and US are aimed at regulating against these challenges, which means that developing countries that do not address these food safety issues may have their access to these markets blocked. Inspection and certification of aquaculture farms and application of Hazard Analysis and Critical Control Points (HACCP) and Good Aquaculture Practices (GAqPs) have been recommended as good approaches for limiting the introduction of potential food hazards in aquaculture products. These approaches are as well incorporated in international regulations and those applying to producers and traders in US and EU to prevent production and trade of unsafe food products. Already most food safety regulatory oversights applied in industrialised countries recognise the concept of equivalence, implying that developing countries that plan to export their products have to comply with the requirements in importing countries. This paper identifies international food safety and other regulatory requirements for production and trade of food from aquaculture and provides an analysis of legislations applied in the European Union (EU) and United States (US) markets that may impact on trade of food of aquaculture origin from developing countries.
Post Insertion Complaints of Removable Dental Prostheses

Objective: To determine the frequent post insertion complaints associated with removable dental prostheses. Furthermore, we planned to identify which type of removable dental prosthesis is related to more complaints. Material & Methods: This study was a survey on 30 consecutive patients wearing removable dental prostheses. Data were collected using a questionnaire and processed in SSPS program version 17 using descriptive statistics for results. Results: The majority of patients (77%) were 50 years or older, and the majority of complaints were in the partial dentures (70%). The chief complaints were of pain followed by discomfort (73.3%). Complaints were equally distributed between genders. Conclusion: We found that pain is the most common complaint with removable dentures, and that the post insertion complaint is not gender related.
Effectiveness of monitoring mechanisms and mitigation of fraud incidents in the public sector

Fraud in the public sector continues to be the major issue for the governments worldwide. Thus, this study examines the extent of monitoring mechanisms within public systems curbing fraud incidents. The authors’ survey concerned three dimensions of monitoring mechanisms: good governance, internal control procedures and fraud prevention programs. This survey has been conducted among various Malaysian government officers. The results show that, generally, misappropriation of assets is ranked as the most frequent fraudulent case in government agencies. Based on regression analysis, internal procedures or policies were significant in reducing fraud incidents. Additionally, both good governance and fraud prevention programs were proven to have a significant relationship with the occurrences of fraud within government agencies. In terms of the practical aspect, the study provides important information for public servants on the effectiveness and usefulness of good governance, internal control procedures, and fraud prevention program in the public sector. This paper provides an interesting contribution to the understanding of fraud incidents inside government agencies.
A New Reduced-Component Hybrid Flying Capacitor Multicell Converter

This paper presents a new multicell topology based on flying capacitor (FC) structure suitable for multilevel converters. The proposed topology employs the concept of phase-shifted carrier pulse width modulation (PWM) with modified modulating signals to generate appropriate PWM signals. The modulation strategy along with all possible switching states are explained. The implementation of the proposed PWM technique is shown by the help of illustrating waveforms. To show the advantages of the proposed structure, different performance criteria are compared with other FC multicell (FCM) structures. Simulation results are used to further evaluate the potential merits of the proposed topology. It is shown that the proposed structure is superior to other FCM-based structures from different standpoints. Specifically, it reduces the number of high-frequency switches, the number of FCs, and at the same time improves the quality of output voltage. A laboratory-type experimental setup is used to validate the modulation strategy and other theoretical findings.
arc-dependent thermal regulation and extragenic suppression of the Escherichia coli cytochrome d operon

In a screen for Escherichia coli genes whose products are required for high-temperature growth, we identified and characterized a mini-Tn10 insertion that allows the formation of wild-type-size colonies at 30 degrees C but results in microcolony formation at 36 degrees C and above (Ts- phenotype). Mapping, molecular cloning, and DNA sequencing analyses showed that the mini-Tn10 insertion resides in the cydB gene, the distal gene of the cydAB operon (cytochrome d). The Ts- growth phenotype was also shown to be associated with previously described cyd alleles. In addition, all cyd mutants were found to be extremely sensitive to hydrogen peroxide. Northern (RNA) blot analysis showed that cyd-specific mRNA levels accumulate following a shift to high temperature. Interestingly, this heat shock induction of the cyd operon was not affected in an rpoH delta background but was totally absent in an arcA or arcB mutant background. Extragenic suppressors of the Cyd Ts- phenotype are found at approximately 10(-3). Two extragenic suppressors were shown to be null alleles in either arcA or arcB. One interpretation of our results is that in the absence of ArcA or ArcB, which are required for the repression of the cyo operon (cytochrome o), elevated levels of Cyo are produced, thus compensating for the missing cytochrome d function. Consistent with this interpretation, the presence of the cyo gene on a multicopy plasmid suppressed the Ts- and hydrogen peroxide-sensitive phenotypes of cyd mutants.
Online--The Future of Newspapers? Germany's Dailies on the World Wide Web

The research project “Online – the future of newspapers? ” examined the producers, their products and the users of German online newspapers. The study on online editorial boards was carried out in the form of a standardized mail survey of all 81 daily newspapers with a WWW presence in May 1997 (return quote: 78%). A questionnaire for the users was placed in the Web, where it could be accessed via links to the homepage of 27 online papers (2524 respondents). In addition five individual websites of newspapers were examined (semi-structured oral interviews with the heads of the editorial boards, content analysis). Almost half of the staff in online editorial boards have journalistic duties. Technical duties are of growing importance. The majority of online editorial boards surveyed depend on the editorial decisions of the print editors. The news sections in online papers consist mainly of duplicates of the printed “parent” paper. Articles for the online version are rarely edited. Very few external links and no graphic or sound effects were added. About two-thirds of users would have chosen the print newspaper and just under a third would have preferred the online version if only one of the versions had been available. The case studies show that online publishers and users base their activities and/or expectations on the print newspaper and use or design their product accordingly.
The Influencing Factors of Impulsive Buying Behaviour in Transmart Carrefour Sidoarjo

This research examined the influence of money availability and idea shopping on impulsive buying behavior. This research was a type of associative-conclusive research to test the magnitude of the influence of money availability directly to impulsive buying behavior or indirectly through idea shopping as an intervening variable. This research used 218 respondents who made unplanned purchases spontaneously and suddenly. This research used Structural Equation Modeling (SEM) method based on General Structured Component Analysis (GSCA). The data used to test the hypothesis were obtained from the results of the distribution of questionnaires. This research finds there is good direct influence between money availability and impulsive buying behavior, or indirectly through idea shopping as an intervening variable. There are several recommendations for the company. First, the salesman should be more intensive in interacting with consumers to influence them. Second, the salesman in each outletmust have good communication skills.
The Relationship Between Investments in Intangible Resources and Liquidation for Financially Distressed Firms

Working with a sample of manufacturing and non-manufacturing firms that filed for bankruptcy protection between 1980 and 2009, the current study examines the relationship between investments in intangibles and the likelihood that the bankrupt firm will either be reorganized or face liquidation. Results for the manufacturing sub-sample show that R&D is the only significant variable associated with liquidation. Over-investment in R&D appears to increase the likelihood of liquidation. Similarly, results for the non-manufacturing sub-sample show that over-investment in advertising appears to increase the likelihood of liquidation. Our conclusion is that firms that are forced to liquidate are often guilty of over-investing in intangible assets.
The link between CSR and Audit Fees: Are Audit Fees associated with CSR?

This dissertation was written as part of the MSc in International Accounting, Auditing and Financial Management at the International Hellenic University. Prior studies show the importance of corporate social responsibility (CSR) for the society and provide steps that have been taken to disclose such information, while there is a paucity in the literature regarding the audit implications. This study examines the impact of CSR on the determination of the Audit Fees, using a large sample of publicly traded European firms for the period 2012-2016. We find a strong positive association between CSR and Audit Fees, meaning that highly rated companies for CSR activities pay more audit fees. But this association becomes negative for companies which are located in countries where there is a well-structured framework for sustainability reporting. We interpret this finding as suggesting that auditing for environmental, social and governance issues is a complex procedure that requires increased audit effort, taking into consideration that the reports will be longer and despite the financial assurance, an auditor has to provide sustainability assurance as well. Also, the recently introduced concept of CSR and the absence of a common legal framework for CSR disclosure, even among European countries, make the audit role more demanding. Taken together, our research linked CSR with Audit Fees and suggest that establishing firms’ nonfinancial disclosures may lead to harmonization of accounting policies, enhancing the transparency. Last but not least, the need for awareness and further accounting education on CSR policies should be highlighted, as a measure to eliminate economic scandals and restrict Audit Fees.
Tumor necrosis factor-alpha and interferon-gamma induce expression of functional Fas ligand on HT29 and MCF7 adenocarcinoma cells.

Tumor cells develop diverse mechanisms to escape from immune surveillance, including expression of Fas ligand (FasL), a 40-kDa type II transmembrane protein that mediates apoptosis by binding to its cognate receptor Fas (APO-1/CD95). Upon activation, T lymphocytes and natural killer (NK) cells express Fas and thus become sensitive to FasL-mediated apoptosis. Here we show that tumor necrosis factor-alpha (TNF-alpha) in addition to interferon-gamma (IFN-gamma) induces cell surface expression of functional FasL in human HT29 colon and MCF7 breast adenocarcinoma cells that constitutively lack cell surface expression of FasL. These cells, expressing FasL, are capable of inducing apoptosis in Fas-positive Jurkat T cells mediated by plasma membrane-bound FasL and soluble forms of FasL. By contrast, mutational deletion of Fas cell surface expression as well as inhibition of caspase family proteases involved in Fas signaling and monoclonal antibodies neutralizing FasL protect Jurkat T cells from apoptosis caused by the FasL-expressing HT29 or MCF7 cells. These results demonstrate that TNF-alpha and IFN-gamma induce expression of functional FasL in adenocarcinoma cells which thereby can kill T lymphocytes by the FasL/Fas pathway.
Employee’s green behavior for environmental sustainability: a case of banking sector in Pakistan

Purpose The purpose of this paper is to find out the relationship between Employee’s Green Behaviors (EGBs) and Environmental Sustainability (ES). Presently, many environmental sustainability issues have impact on organizations e.g., energy cost and climate change. In business world, there is a positive trend among organizations to start reporting over performance of environmental sustainability keeping their role as Corporate Social Responsibility (CSR) alive. Design/methodology/approach Self-administered questionnaires were floated to gather data from employees of manufacturing and service industry. In order to analyze the collected data, Regression Analysis and Correlation Coefficient were employed to check hypotheses. Statistical package of Social sciences (SPSS) has been used for data analysis. Findings Results reveal that there is direct positive relationship between employees’ green behavior and environment sustainability. Five dimensions working sustainability; conserving, avoiding harm, influenci.
Expanding the e-commerce system success theory: The impact of online visibility - Case Google

Laakkonen, Vesa Expanding the e-commerce system success theory: The impact of online visibility Case Google Jyväskylä: University of Jyväskylä, 2018, 68 p. Information Systems, Master’s Thesis Supervisor: Rousi, Rebekah New websites are being created every day and they are all competing for internet users’ attention. E-commerce systems websites selling services or products online that are not visible or easily found are less likely to be used, subsequently decreasing their chances of success. There are several e-commerce system theories made which attempt to describe the components of how ecommerce system success is created. Nevertheless, hardly any of these theories have named online visibility as a success defining variable. In this study, the focus is on studying how organic search engine visibility on Google (a form of online visibility) impacts e-commerce system use and success. The study also examines any other possible factors that might explain how a search engine user ends up using a particular e-commerce site from Google. As a result of this, we are able to gain a more detailed picture of the whole phenomenon and discover how e-commerce system owners could increase the use rate of their system and thus, the likelihood of success. The research was undertaken through conducting a literature review explaining key concepts and introducing existing e-commerce system success theories. Empirical research was done by utilizing user tests and interviews. The main findings of the research illustrate that high organic search engine visibility is not the reason for ecommerce system use, but rather use is a result of high visibility. Another finding was that there are more than just a few factors users evaluate when choosing an e-commerce system to use.
Responsiveness to Intervention in Children with Dyslexia.

We examined the responsiveness to a 12-week phonics intervention in 54 s-grade Dutch children with dyslexia, and compared their reading and spelling gains to a control group of 61 typical readers. The intervention aimed to train grapheme-phoneme correspondences (GPCs), and word reading and spelling by using phonics instruction. We examined the accuracy and efficiency of grapheme-phoneme correspondences, decoding words and pseudowords, as well as the accuracy of spelling words before and after the intervention. Moreover, responsiveness to intervention was examined by studying to what extent scores at posttest could directly or indirectly be predicted from precursor measures. Results showed that the children with dyslexia were significantly behind in all reading and spelling measures at pretest. During the intervention, the children with dyslexia made more progress on GPC, (pseudo)word decoding accuracy and efficiency, and spelling accuracy than the typical reading group. Furthermore, we found a direct effect of the precursor measures rapid automatized naming, verbal working memory and phoneme deletion on the dyslexic children's progress in GPC speed, and indirect effects of rapid automatized naming and phoneme deletion on word and pseudoword efficiency and word decoding accuracy via the scores at pretest. Copyright © 2016 John Wiley & Sons, Ltd.