Miracle-dz/UniFAR-FTUs huggingface dataset:
Deterministic delay guarantee in OBS edge node for premium services

In optical burst switched (OBS) networks, the queueing delay in ingress edge node is an important performance measure. In this paper, we propose a deterministic delay model and derive the upper bound of the burst queueing delay in an edge node. On this basis, the edge-to-edge delay guarantee framework for premium services is further outlined.
Multiple stress effects of Vision® herbicide, pH, and food on zooplankton and larval amphibian species from forest wetlands

As part of a multiple‐tier research program, interactions of the herbicide Visionn® (glyphosate) with two stressors, pH and food level, were examined. Effects of the formulated product Vision were tested at two test concentrations (0.75 and 1.50 mg acid equivalent/L), two pH levels (pH 5.5 and 7.5), and under high and low food concentrations. Effects of each stressor alone and in combination were examined using two common wetland taxa: Zooplankton, Simocephalus vetulus, and tadpoles (Gosner stage 25) of Rana pipiens. For S. vetulus, survival, reproduction, and development time were measured; survival was measured for R. pipiens. For both species, significant effects of the herbicide were measured at concentrations lower than the calculated worst‐case value for the expected environmental concentration ([EEC], 1.40 mg acid equivalent/L). Moreover, high pH (7.5) increased the toxic effects of the herbicide on all response variables for both species even though it improved reproductive rate of S. vetulus over pH 5.5 in the absence of herbicide. Stress due to low food alone also interacted with pH 5.5 to diminish S. vetulus survival. These results support the general postulate that multiple stress interactions may exacerbate chemical effects on aquatic biota in natural systems.
The Odyssey of TAVR from concept to clinical reality.

On 16 April 2002, my colleagues and I performed, in an inoperable and desperately ill man with critical calcific aortic stenosis (AS), the first clinical percutaneous implantation of an aortic valve bioprosthesis. As of 2013, more than 80,000 patients have been treated; and transcatheter aortic valve replacement (TAVR), so strongly criticized by all the experts throughout the early years, continues to grow in parallel with its constant technological improvements. Transcatheter aortic valve replacement can now be recognized as a medical breakthrough. It is a revolutionary technology that meets an unfulfilled clinical need for a common disease, is validated by rigorous evidence-based studies, and is applicable worldwide. We report here the main phases of this 20-year odyssey and briefly consider the prospects of TAVR, which remains in continuous development.
Complex mass-movement terrains in the western Cascade Range

A variety of mass-movement processes interact to form complex mass-movement terrains in the western Cascade Range in Oregon. Slow, deep-seated (>5 m depth) processes of creep, slump, and earthflow operate simultaneously and sequentially, resulting in unstable conditions that may initiate rapid, shallow (<5 m) soil mass movements on hillslopes and debris torrents in stream channels. This combination of massmovement processes supplies large volumes of sediment to streams and determines the geometry of the channel and valley floor. Creep movement in western Oregon has been monitored at rates as high as 15 mm/yr. Relative movement between discrete blocks in the Lookout Creek earth flow ranges up to nearly 10 times as fast. Movement rate accelerates during periods of high moisture availability. Geomorphic observations and tree-ring analysis indicate that mass-movement terrains may have histories spanning centuries and possibly millennia.
A comparative study of clinical and food isolates of Listeria monocytogenes and related species

SUMMARY Ninety-six isolates of presumptive or confirmed Listeria monocytogenes were obtained from local clinical (30 isolates) or food laboratories (66 isolates). Minimal biochemical analysis identified only 80% of these isolates as L. monocytogenes the remaining included L. seeligeri, 1%, or the non-haemolytic L. innocua, 19%. The 27 clinical and 50 food isolates, mainly from meat products, frozen confectionaries, and cheeses, confirmed as L. monocytogenes were compared biochemically and serologically. Twenty-one isolates, including some strains of L. innocua and L. seeligeri, were examined for pathogenicity in immunocompromized mice and 44 typed using bacterial restriction endonuclease DNA analysis (BRENDA). Only isolates of L. monocytogenes were found to be pathogenic. Biovar-typing of the isolates was unreliable and provided poor discrimination. Serogroups 1/2 and 4 predominated among clinical and food isolates and BRENDA provided better discrimination among isolates. Ten stable and reproducible restriction patterns were observed among the Listeria sp. isolates studied. Overall, a combination of techniques gave the best discrimination and indicated their potential for use as epidemiological tools.
Identification of a herpes simplex labialis susceptibility region on human chromosome 21.

BACKGROUND Most of the United States population is infected with either herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2, or both. Reactivations of HSV-1 infection cause herpes simplex labialis (HSL; cold sores or fever blisters), which is the most common recurring viral infection in humans. METHODS To investigate the possibility of a human genetic component conferring resistance or susceptibility to cold sores (i.e., a HSL susceptibility gene), we conducted a genetic linkage analysis that included serotyping and phenotyping 421 individuals from 39 families enrolled in the Utah Genetic Reference Project. RESULTS Linkage analysis identified a 2.5-Mb nonrecombinant region of interest on the long arm of human chromosome 21, with a multipoint logarithm of odds score of 3.9 noted near marker abmc65 (D21S409). Nonparametric linkage analysis of the data also provided strong evidence for linkage (P = .0005). This region of human chromosome 21 contains 6 candidate genes for herpes susceptibility. CONCLUSIONS The development of frequent cold sores is associated with a region on the long arm of human chromosome 21. This region contains several candidate genes that could influence the frequency of outbreaks of HSL.
Resolution of chronic severe refractory thrombocytopenia after treatment of hypothyroidism

The case of a 52 year old woman with chronic severe refractory thrombocytopenia is presented. Over a three year period, her platelet count was persistently less than 20 × 109/litre (normal range, 150–400). She required repeated hospital admission for management of bleeding and received multiple blood transfusions. She was given repeated courses of steroids, immunosuppression, immunoglobulin, and splenectomy, without success, in an attempt to stop the chronic blood loss. Eventually, she was found to be profoundly hypothyroid. On correction of her thyroid deficiency the platelet count returned to the normal range and all bleeding stopped. The platelet count remains in the normal range three years later.
Perception of Corruption and the Erosion of Social Capital in Croatia 1995-2003

The paper analyses the changes at the level of social capital (SC) in Croatia during the period of 1995 to 2003. Starting from theoretical and empirical arguments which link SC with economic growth, social development and political stability, the author uses data from two research projects carried out on representative national samples (World Values Survey – Croatia 1995 and South East European Social Survey, 2003), in order to establish and discuss changes at the SC level. The conducted analyses show a decrease in social capital, which cannot be solely attributed to the situational effect present during the 1995 survey. The paper analyses the suitability of the standard macro approach to measuring SC in the transitional context, but also points out the influence of perception of the extent of corruption on the negative dynamics of SC.
Broadband Wireless Internet Forum White Paper BWIF - Bringing Broadband Wireless Access Indoors Document Number WP-4_TG-1 Version 1.0

Notice BWIF DISCLAIMS ANY AND ALL WARRANTIES, WHETHER EXPRESSED OR IMPLIED, INCLUDING (WITHOUT LIMITATION) ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. BWIF reserves the right to make changes to the document without further notice. The document may be updated, replaced or made obsolete by other documents at any time. BWIF (acting itself or though its designees), is, and shall at all times, be the sole entity that may authorize the use of certification marks, trademarks, or other special designations to indicate compliance with these materials. About the Broadband Wireless Internet Forum (BWIF) BWIF, formed in July 2000, is an incorporated, non-profit association of industry-leading companies that will work together to ensure adoption of a single, unified broadband wireless access industry standard. Members of BWIF will drive product roadmaps that will lower product costs, simplify deployment of advanced services, and ensure the availability of interoperable standards-based solutions based on Vector Orthogonal Frequency Division Multiplexing (VOFDM) technology. BWIF members agree to cross-license to other BWIF members, the technologies required to implement the standard on a worldwide, royalty-free basis.
What's the difference? comparing humans and machines on the Aurora 2 speech recognition task

The comparison of human speech recognition (HSR) and machine performance allows to learn from the differences between HSR and automatic speech recognition (ASR) and serves as motivation for using auditory-inspired strategies in ASR. The recognition of noisy digit strings from the Aurora2 framework is one of the most widely used tasks in the ASR community. This paper establishes a baseline with a close-to-optimal clas-siﬁer, i.e., our auditory system by comparing results from 10 normal-hearing listeners to the Aurora2 reference system using identical speech material. The baseline ASR system reaches the human performance level only when the signal-to-noise ratio is increased by 10 or 21 dB depending on the training condition. The recognition of 1-digit recordings was found to be considerably better for HSR, indicating that onset detection is an important feature neglected in standard ASR systems. Results of recent studies are considered in the light of these ﬁndings to measure how far we have come on the way to human speech recognition performance.
Phase I trial of imexon in patients with advanced malignancy.

PURPOSE Imexon, a pro-oxidant small molecule, has antitumor activity in preclinical models. The drug induces apoptosis through accumulation of reactive oxygen species. The purpose of this trial was to define the maximum-tolerated dose (MTD), toxicities, pharmacokinetics, and pharmacodynamics of imexon in patients with advanced cancers. PATIENTS AND METHODS Forty-nine patients with metastatic cancer received intravenous imexon over 30 to 45 minutes for 5 consecutive days (one course) every other week (days 1 through 5 and 15 through 19) monthly. Doses were initially escalated using an accelerated trial design and then a modified Fibonacci method. Plasma imexon levels and six different thiols were measured by high-performance liquid chromatography assays. RESULTS There were 13 dose levels evaluated, from 20 mg/m2/d to 1,000 mg/m2/d. The MTD recommended for phase II studies was 875 mg/m2/d for 5 days every 2 weeks (n = 9 patients). The two dose-limiting toxicities at 1,000 mg/m2/d involved grade 3 abdominal pain and fatigue and grade 4 neutropenia, which occurred in one patient each. Other common toxicities included nausea and vomiting (58%) and constipation (63%); both were managed well with prophylactic medications. One partial response was obtained in a heavily pretreated patient with non-Hodgkin's lymphoma. Pharmacokinetic studies showed dose-independent clearance, with a 95-minute mean half-life. Plasma thiol studies showed a dose- and area under the curve-dependent decrease in cystine levels 8 hours after dosing at 750 mg/m2/d. CONCLUSION The phase II recommended dose of imexon is 875 mg/m2/d for 5 days every other week. A decrease in plasma thiols did correlate with imexon exposure.
Histone H4 gene is transcribed in S phase but also late in G2 phase in Physarum polycephalum

The myxomycete Physarum polycephalum contains two types of H4 histone genes. Southern blotting of restriction endonuclease fragments of P. polycephalum DNA and hybridization to a cloned probe labelled by nick‐translation indicate that there are only one or two copies of each H4 gene per haploid genome. A cloned homologous genomic probe was used to study the cellular abundance of H4 mRNA during the cell cycle. We report that the H4 mRNA is not only transcribed in S phase as previously described for other organisms but that transcription of the H4 gene also occurs at the end of G2 phase. Since no translation of the histone messenger was observed in G2 phase this suggests that the histone mRNA synthesized in G2 constitutes a pool of molecules in anticipation of the next S phase.
Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats

El plomo es uno de los mas importantes contaminantes ambientales, toxico para la mayoria de los sistemas organicos. La D-penicillamina (D-P) es una droga quelante, la cual se ha usado para el tratamiento de la toxicidad por plomo durante varios anos. Este estudio fue dirigido para evaluar la eficacia de la D-P en la reduccion de los efectos del plomo en los indices hematologicos. Este estudio se realizo en 36 machos adultos de ratas Wistar albinas de 6-8 semanas, en la Universidad de Ciencias Medicas de Gorgan, Iran. Al inicio, las ratas machos adultas fueron expuestas al acetato de plomo en el agua de beber. Despues de 8 semanas, 6 ratas se seleccionaron para evaluar los efectos de la toxicidad del plomo en muestras sanguineas. Las restantes ratas expuestas fueron divididas para su recuperacion, a las cuales se les administro agua destilada y un grupo con tratamiento al que se le suministro D-P. Despues de la exposicion al plomo, el conteo de globulos rojos se incremento ligeramente, pero la hemoglobina y el hematocrito disminuyeron. Tambien el MCV y el valor de MCH disminuyeron significativamente (P< 0,05). Los valores de RDW, PDW y MPV fueron significativamente altos en las ratas expuestas al plomo (p< 0,05). Luego del periodo de recuperacion, la mayoria de los parametros se acercaron al valor normal y no hubo diferencias significativas entre el grupo recuperado y con tratamiento. Este estudio mostro que los efectos hematologicos del plomo son reversibles y la administracion de D-P no juega un rol importante en la intoxicacion subcronica
Use of diagnostic ultrasound in trophoblastic neoplasms and ovarian tumors

Analyses of the data on the ultrasonic diagnostic accuracies are presented for the cases of hydatidiform mole and ovarian tumors. These data are derived from two sources: the State University of New York Downstate Medical Center (SUNY‐DMC) and the Chiba University School of Medicine (Chiba U.), Japan. Diagnosis of hydatidiform mole was correct in 47 (92.2%) of 51 (SUNY‐DMC) and 66 (91.6%) of 72 cases (Chiba U.). The incidences of lutein cysts were 29.4% (SUNY‐DMC) and 18.1% (Chiba U.). Ultrasound plays an important role in the postmolar follow‐up: increased intrauterine echoes in the subinvoluted uterus may signal a developing invasive mole or choriocarcinoma. Ultrasonic diagnoses of 223 (SUNY‐DMC) and 183 (Chiba U.) ovarian tumors have been analyzed and the rates of diagnostic errors for the individual tumors are presented. Solid ovarian tumors appear to be more difficult to diagnose than cystic ovarian tumors.
A discontinous Galerkin finite element method with an efficient time integration scheme for accurate simulations

A discontinuous Galerkin finite element method (DG-FEM) with a highly-accurate time integration scheme is presented. The scheme achieves its high accuracy using numerically constructed predictor-corrector integration coefficients. Numerical results show that this new time integration scheme uses considerably larger time steps than the fourth-order Runge-Kutta method when combined with a DG-FEM using higher-order spatial discretization/basis functions for high accuracy.
Pectins from Apple Pomace

Extractions of apple pectins from apple pomace were performed using an experimental design with 2 2 factorial. The extractor agent was 5 % (w/v) citric acid and the variables were time (30, 50 and 80 min) and temperature (50, 75 and 100 °C). The best yield (16.8 %) was obtained using higher temperatures (100 °C; 80 min). Monosaccharide composition of the pectic fractions was similar to others already described.
Antimicrobial Activity of the Marine Algal Extracts against Selected Pathogens

The inhibitory effect of Ulva lactuca (Chlorophyta), Dilophus spiralis (Phaeophyta) and Jania rubens (Rhodophyta) marine algae species has been evaluated against 2 Grampositive bacterial (Streptococcus pyogenes and Micrococcus luteus); 2 Gram-negative bacterial (Shigella flexneri and Vibrio cholerae) and 2 fungal (Candida albicans and Aspergillus niger) isolates using aqueous and six organic extracts (methanol, ethanol, chloroform, acetone, ethyl acetate and hexane). Data revealed that the M. luteus bacteria was the most sensitive pathogen by showing the highest zone of inhibitions (ZIs) of 17 mm with the lowest Minimum Inhibitory Concentration (MIC) of 26.7 μgmL and the lowest Minimum Bactericidal Concentration (MBC) of 53.3 μg mL with chloroform D. spiralis extract. Whereas, aqueous extracts were not active against all selected pathogens regardless of the examined algae species. Based upon data presented herein, chloroform D. spiralis extract was the most active against examined pathogens. Thereby, future performance research in D. spiralisis requested due to their high effectiveness as a cheap antimicrobial agent.
HCI and NBTI including the effect of back-biasing in thin-BOX FD-SOI CMOSFETs

Hot carrier injection (HCI) and negative bias temperature instability (NBTI) of fully depleted silicon-on-insulator (FD-SOI) CMOSFETs with thin-buried oxide (BOX) were investigated for the first time. A comparison with conventional bulk devices showed that no halo implant in this structure produces better reliability. The impact of back-biasing in thin-BOX FD-SOI devices on reliability is also reported.
Swift observations of GRB 050904: the most distant cosmic explosion ever observed

Context. Swift discovered the high redshift (z = 6.29) GRB 050904 with the Burst Alert Telescope (BAT) and began observing with its narrow field instruments 161 s after the burst onset. This gamma-ray burst is the most distant cosmic explosion ever observed. Because of its high redshift, the X-ray Telescope (XRT) and BAT simultaneous observations provide 4 orders of magnitude of spectral coverage (0.2-150 keV; 1.4-1090 keV in the source rest frame) at a very early source-frame time (22 s). The X-ray emission was monitored by the XRT up to 10 days after the burst. Aims. We present the analysis of BAT and XRT observations of GRB 050904 and a complete description of its high energy phenomenology. Methods. We performed time resolved spectral analysis and light curve modeling. Results. GRB 050904 was a long, multi-peaked, bright GRB with strong variability during its entire evolution, The light curve observed by the XRT is characterized by the presence of a long flaring activity lasting up to 1-2 h after the burst onset in the burst rest frame, with no evidence of a smooth power-law decay following the prompt emission as seen in other GRBs. However, the BAT tail extrapolated to the XRT band joins the XRT early light curve and the overall behavior resembles that of a very long GRB prompt. The spectral energy distribution softens with time, with the photon index decreasing from -1.2 during the BAT observation to -1.9 at the end of the XRT observation. The dips of the late X-ray flares may be consistent with an underlying X-ray emission arising from the forward shock and with the properties of the optical afterglow reported by Tagliaferri et al. (2005b, AA very low metallicities of the progenitor at these epochs may provide an explanation. © ESO 2007.
Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival

Polycomb group genes (PcGs) have been implicated in cancer based on altered levels of expression observed in certain tumors and the behavior of cultured cells containing inserted PcG transgenes. Endometrial stromal tumors provide evidence for a direct causal relationship because they contain several chromosomal translocations and resultant gene fusions involving PcGs, the most common of which joins portions of theJAZF1 gene to the PcGJJAZ1/SUZ12. We show here that both benign and malignant forms of this tumor have theJAZF1–JJAZ1 fusion but only the malignant form also exhibits exclusion of the unrearrangedJJAZ1 allele. To evaluate the effects of both theJJAZ1/SUZ12 fusion and allelic exclusion on functions related to cell growth, we studied HEK293 cells that were modified with respect toJJAZ1 expression. We found that theJAZF1–JJAZ1 fusion restored levels of the polycomb protein EZH2 and histone 3 lysine 27 trimethylation, which were reduced by knockdown of endogenous JJAZ1. At the same time, the presence ofJAZF1–JJAZ1 markedly inhibited apoptosis and induced above normal proliferation rates, although the latter effect occurred only when normalJJAZ1 was suppressed. Our findings suggest a genetic pathway for progression of a benign precursor to a sarcoma involving increased cell survival associated with acquisition of a PcG rearrangement, followed by accelerated cellular proliferation upon allelic exclusion of the unrearranged copy of that gene. Furthermore, these results indicate the likely functional importance of allelic exclusion of genes disrupted by chromosomal translocations, as seen in a variety of other cancers.
Consumer trust, perceived security and privacy policy: Three basic elements of loyalty to a web site

Purpose – The purpose of this paper is to analyze the effect of privacy and perceived security on the level of trust shown by the consumer in the internet. It also aims to reveal and test the close relationship between the trust in a web site and the degree of loyalty to it.Design/methodology/approach – First, there is an explanation of the main attributes of the concepts examined, with special attention being paid to the multi‐dimensional nature of the variables and the relationships between them. This is followed by an examination of the validation processes of the measuring instruments.Findings – Specifically, the study reveals that an individual's loyalty to a web site is closely linked to the levels of trust. Thus, the development of trust not only affects the intention to buy, as shown by previous researchers, but it also directly affects the effective purchasing behavior, in terms of preference, cost and frequency of visits, and therefore, the level of profitability provided by each consumer. In ad.