Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Yield and Quality of Sorghum and Millet as Alternative Forage Crops to Corn under Normal and Deficit Irrigation Regimes

Two field experiments were conducted to evaluate the possibility of increasing diversity of winter cereals- based double cropping systems and their responses to deficit irrigation. In experiment 1, forage yield and quality of three corn hybrids, three sorghum cultivars and three species of millet (foxtail, common and pearl millet) were evaluated. Based on the results obtained from experiment 1, corn hybrid S.C. 704, sorghum cultivar Jumbo, and pearl millet were selected for further investigations. In experiment 2, the effects of irrigation treatments of I100, I75 and I50 (providing 100%, 75%, and 50% of the corn estimated water requirement, respectively) were investigated on selected crops. Sorghum showed higher drought tolerance, but produced lower yield than pearl millet and corn, except at I50. The highest dry forage yield in I100 was produced by corn followed by pearl millet. A reduction of 25% in the amount of irrigation water reduced the yield of corn, sorghum and millet by 28, 13 and 24%, respectively. Corn had the highest value of digestibility and relative feed value (RFV). Deficit irrigation led to a rise in crude protein (CP) and acid detergent fiber (ADF) content, and caused significant reductions in digestibility and RFV values in the three crop species. Results indicated that pearl millet and sorghum could be considered as reasonable alternatives to corn in a double cropping system under moderate and severe deficit irrigation conditions, respectively.
Karyotypic abnormalities and molecular analysis of Y chromosome microdeletion in Iranian Azeri Turkish population infertile men

ABSTRACT Infertility is one of the major health-threatening problems in communities which may lead to psychological problems among couples. Y chromosome abnormalities and microdeletions have recently been considered as one of the male infertility factors. The aim of this study was to evaluate different chromosomal disorders and azoospermia factor b (AZFb), AZFc and AZFd microdeletions in idiopathic non-obstructive oligo or azoospermia infertile men. One hundred infertile (78 azoospermia and 22 oligospermia) and 100 fertile men were included in this study. Luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were evaluated by electrochemiluminescence. Karyotyping was performed according to standard methods and interpreted using the International System for Human Cytogenetic Nomenclature (ISHCN) recommendation. For Y chromosome microdeletion analysis, a multiplex polymerase chain reaction (PCR) was performed using STS primers. Higher FSH (24.32 ± 15.32 versus 8.02 ± 3.37, p < 0.0001) and LH (14.97 ± 8.26 versus 5.42 ± 2.73, p < 0.0001) were observed in infertile patients compared to their fertile counterpart. Additionally, 14% of infertile patients exhibited abnormal karyotype. The frequency of Y chromosome microdeletions in azoospermic and oligospermic patients was 32.05% (25/78) and 0% (0/22), respectively. Additionally, in azoospermic patients, the highest microdeletion frequency was related to the AZFc region (80%). Our data indicate the presence of chromosomal changes in the most infertile men, suggesting karyotype and molecular analysis of Y chromosome microdeletions for genetic counseling before assisted reproduction. Abbreviations: ART: assisted reproductive technology; AZF: azoospermia factor; DAZ: deleted in azoospermia; FCS: fetal calf serum; FSH: follicle stimulating hormone; LH: luteinizing hormone; PCR: polymerase chain reaction; SRY: sex-determining region Y; STS: sequence-tagged sites
Phosphatidylethanolamine-Binding Protein 1 Ameliorates Ischemia-Induced Inflammation and Neuronal Damage in the Rabbit Spinal Cord

In a previous study, we utilized a proteomic approach and found a significant reduction in phosphatidylethanolamine-binding protein 1 (PEBP1) protein level in the spinal cord at 3 h after ischemia. In the present study, we investigated the role of PEBP1 against oxidative stress in NSC34 cells in vitro, and ischemic damage in the rabbit spinal cord in vivo. We generated a PEP-1-PEBP1 fusion protein to facilitate the penetration of blood-brain barrier and intracellular delivery of PEBP1 protein. Treatment with PEP-1-PEBP1 significantly decreased cell death and the induction of oxidative stress in NSC34 cells. Furthermore, administering PEP-1-PEBP1 did not show any significant side effects immediately before and after ischemia/reperfusion. Administration of PEP-PEBP1 improved the Tarlov’s neurological score at 24 and 72 h after ischemia, and significantly improved neuronal survival at 72 h after ischemia based on neuronal nuclei (NeuN) immunohistochemistry, Flouro-Jade B staining, and western blot study for cleaved caspase 3. PEP-1-PEBP1 administration decreased oxidative stress based on malondialdehyde level, advanced oxidation protein products, and 8-iso-prostaglandin F2α in the spinal cord. In addition, inflammation based on myeloperoxidase level, tumor necrosis factor-α level, and high mobility group box 1 level was decreased by PEP-1-PEBP1 treatment at 72 h after ischemia. Thus, PEP-1-PEBP1 treatment, which decreases oxidative stress, inflammatory cytokines, and neuronal death, may be an effective therapeutic strategy for spinal cord ischemia.
Alternative chronologies for Late Quaternary ( Last Interglacial – Holocene ) deep sea sediments via optical dating of silt-sized quartz

We summarize the results of a test on the potential of optical dating for the age assessment of Late Quaternary deep-sea sediments. Our approach combines a single aliquot regeneration (SAR) protocol for equivalent dose (De) estimation on fine silt-sized quartz with a time-dependent evaluation of supported and unsupported long-lived radioisotopes within the deposited sediment matrix. For this purpose nine samples from two independently dated deep-sea cores from the Indian Ocean were obtained. The SAR analysis resulted in mean De estimates with precisions ranging from 0.9% to 3.7%. Combination of these data with measured radioisotope concentrations resulted in stratigraphically sensible ages ranging from ca 7 to 120 ka. These ages exhibit good agreement with existing chronologies for the cores based on radiocarbon age determinations and correlation of key volcanic, palaeoecological and isotopic events. Optical dating may provide an important additional dating method for Late Quaternary deepsea sediments. r 2003 Elsevier Science Ltd. All rights reserved.
EVIDENCE OF CARRYING CAPACITY EFFECTS IN NEWFOUNDLAND

Newfoundland moose (Alces alces americana) increased following 1904, the year of successful introduction, to peak numbers in 1958. The population subsequently decreased to record low numbers by 1973, when an area-quota management system was instituted throughout the island (112,000 km) in 38 moose management areas, in part, to respond to issues related to habitat and accessibility for hunting. Subsequent quota-management manipulations permitted the islandwide population to increase in accessible areas to record high numbers by 1986, after which populations again decreased, to a 1999 estimate of 125,000 animals (post-hunt). We hypothesise that, unlike most studied irruptions of cervid populations, moose populations in Newfoundland, and subsequently habitat carrying capacity (K), decreased on inaccessible range following 1958 to very low density, from which both have never recovered. Decreases in relative numbers of young moose seen while hunting and during winter classifications are consistent with increases in the number of moose seen during increase phases during 1966–99. These observations are less obvious for less accessible management areas. We explore other recruitment and density relationships as they have been developed in association with our estimate of K in moose for Newfoundland. We illustrate that, although some decrease in moose numbers following 1958 and 1986 was the result of management, changes to population size and to K also resulted in reduction in productivity, such that density dependence explains > 10% and up to 76% of hunter-observed recruitment. ALCES VOL. 38 : 123-141 (2002)
Rising Mortality From Alcohol-Associated Liver Disease in the United States in the 21st Century.

OBJECTIVES In contrast with other developed nations, life expectancy is decreasing in the United States, in part due to increasing mortality from alcohol-associated liver disease (ALD). Up-to-date estimates of ALD mortality are necessary for setting public health priorities to reverse this concerning trend. We therefore aimed to assess current (2017) estimates of ALD mortality and temporal trends from 1999 to 2017. METHODS Using national data from the Centers for Disease Control and Prevention, we analyzed stratified ALD mortality rates between 1999 and 2017. We determined the age-adjusted death rates, stratified by sex and categorized by age, race/ethnicity, urbanization, and census region. We also identified statistically significant changes in the annual rate difference (ARD), annual percentage change (APC), and average APC in ALD mortality. RESULTS In 2017, mortality from ALD was higher than any other year since 1999 with age-adjusted rates of 13.1 per 100,000 (95% confidence interval [CI] 12.9-13.3) in men and 5.6 per 100,000 (95% CI 5.4-5.7) in women. Mortality was highest among men and women who were middle aged, Native American, and from rural areas. Since 2006, ALD mortality has increased in almost every age group and race with the exception of non-Hispanic black men. Absolute increases in mortality rates have been particularly pronounced in Native American women (2005-2017 ARD 0.8, 95% CI 0.6-0.9), non-Hispanic/white men (2006-2017 ARD 0.4, 95% CI 0.3-0.4), and non-Hispanic/white women (2013-2017 ARD 0.4, 95% CI 0.3-0.5). DISCUSSION Mortality from ALD is increasing over time in most demographic groups. Increased effort is needed to develop targeted public health strategies to address high and increasing ALD mortality.
Illuminating Economic Growth

This paper seeks to illuminate the uncertainty in official GDP per capita measures using auxiliary data. Using satellite-recorded nighttime lights as an additional measurement of true GDP per capita, we provide a statistical framework, in which the error in official GDP per capita may depend on the country’s statistical capacity and the relationship between nighttime lights and true GDP per capita can be nonlinear and vary with geographic location. This paper uses recently developed results for measurement error models to identify and estimate the nonlinear relationship between nighttime lights and true GDP per capita and the nonparametric distribution of errors in official GDP per capita data. We then construct more precise and robust measures of GDP per capita using nighttime lights, official national accounts data, statistical capacity, and geographic locations. We find that GDP per capita measures are less precise for middle and low income countries and nighttime lights can play a bigger role in improving such measures.
Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets

Gene expression governs cell fate, and is regulated via a complex interplay of transcription factors and molecules that change chromatin structure. Advances in sequencing-based assays have enabled investigation of these processes genome-wide, leading to large datasets that combine information on the dynamics of gene expression, transcription factor binding and chromatin structure as cells differentiate. While numerous studies focus on the effects of these features on broader gene regulation, less work has been done on the mechanisms of gene-specific transcriptional control. In this study, we have focussed on the latter by integrating gene expression data for the in vitro differentiation of murine ES cells to macrophages and cardiomyocytes, with dynamic data on chromatin structure, epigenetics and transcription factor binding. Combining a novel strategy to identify communities of related control elements with a penalized regression approach, we developed individual models to identify the potential control elements predictive of the expression of each gene. Our models were compared to an existing method and evaluated using the existing literature and new experimental data from embryonic stem cell differentiation reporter assays. Our method is able to identify transcriptional control elements in a gene specific manner that reflect known regulatory relationships and to generate useful hypotheses for further testing.
Economy-wide Estimates of Rebound Effects: Evidence from Panel Data

Energy consumption and greenhouse emissions across many countries have increased over time despite widespread energy efficiency improvements. One explanation offered in the literature is the rebound effect (RE), however there is a debate about its magnitude and the appropriate model for estimating it. Using a combined stochastic frontier analysis (SFA) and two-stage dynamic panel data approach, we explore these two issues of magnitude and model for 55 countries over the period 1980 to 2010. Our central estimates indicate that in the short-run, 100% energy efficiency improvement is followed by 90% rebound in energy consumption, but in the long-run it leads to a 136% decrease in energy consumption. Overall, our estimated cross-country RE magnitudes indicate the need to consider or account for RE when energy forecasts and policy measures are derived from potential energy efficiency savings.
Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation

Deregulation of different intracellular signaling pathways is a common feature in cancer. Numerous studies indicate that persistent activation of the phosphoinositide 3-kinase (PI3K) pathway is often observed in cancer cells. 3-phosphoinositide dependent protein kinase-1 (PDK1), a transducer protein that functions downstream of PI3K, is responsible for the regulation of cell proliferation and migration and it also has been found to play a key role in different cancers, pancreatic and breast cancer amongst others. As PI3K is being described to be aberrantly expressed in several cancer types, designing inhibitors targeting various downstream molecules of PI3K has been the focus of anticancer agent development for a long time. In particular, dual inhibitory drugs targeting key signaling molecules in the PI3K pathway have attracted the attention of scientists. Several drugs have progressed to clinical trials, with limited success due to toxicity and bioavailability concerns. Very few anticancer drugs targeting the PI3K pathway have been approved for clinical use and their efficacy is particularly limited towards certain tumors such as pancreatic cancer. Here, we tested two drugs displaying dual inhibitory activity towards PDK1 and Aurora kinase A in a panel of pancreatic cancer cell lines and in two in vivo models of pancreatic cancer. Our data show that both inhibitors are able to impair cell proliferation and clonogenic potential in pancreatic cancer cells. However, the limited activity of both compounds in vivo indicates that further optimization of the pharmacokinetics properties is required.
Photogrammetric Outcomes of Primary Nasal Correction in Unilateral Cleft Lip Patients: Early Childhood Results From a Single Surgeon's Experience.

BACKGROUND Concerns of nonlasting results and potential nasal growth damage precluded cleft nasal correction at the time of initial cleft lip repair. Our goal was to evaluate the outcome of primary cleft nasal correction in our patients with unilateral cleft lip. METHODS A retrospective review of patients with complete and incomplete unilateral cleft lip who underwent primary cleft nasal correction from 2010 to 2017 by the same surgeon was performed. The cleft-to-noncleft nostril height, width, one-fourth medial part of nostril height, nasal sill height, and nostril area ratios, as well as inner nostril height-to-width ratios were determined from standard basilar view photographs taken in different time points (T1, <3 months; T2, 3-12 months; T3, 12-36 months; and T4, >36 months after surgery). A 5-point visual analog scale (1 = worst, 5 = best) was used to assess each patient's nose appearance. RESULTS Seventy-two patients were identified (66.7% male, 51.3% with a complete cleft lip). Average visual analog scale scores T1-T4 were 3.88 ± 0.85, 3.72 ± 0.93, 3.54 ± 0.99, and 3.40 ± 0.71, respectively. Intraclass correlation ranged from 0.61 to 0.94. A significant decrease [mean difference (SD)] was found for cleft-to-noncleft nostril width ratio [0.15 (0.18)] from T1 to T2, and an increase for one-fourth medial height ratio [-0.09 (0.07)] and for inner nostril height-to-width ratio in the noncleft side [-0.23 (0.25)] from T1 to T3. Thirteen patients required secondary surgical revision. CONCLUSION Based on photogrammetry, primary cleft nasal correction in our patients with unilateral cleft lip achieved acceptable and stable outcomes during early childhood.
Flowering traits in tetraploid Brachiaria ruziziensis breeding

Tetraploid Brachiaria ruziziensis genotypes which reproduce sexually are essential for the breeding of other species of the Brachiaria genus which reproduce by apomixis. Aiming at studying the available phenotypic and genetic variability in the breeding population of B. ruziziensis, it was estimated the parameters heritability and genetic and phenotypic correlations between the traits associated with flowering, and the traits responsible for forage yield and nutritional quality. Seventeen traits in 1180 individuals from 59 open pollinated families were studied, and the data were analyzed by mixed model methods. Individuals with sparse flowering presented higher breeding values for total dry matter, yield, and total number of panicles per plant than individuals with early or late flowering. Considering breeding population differences on flowering behavior, on individual narrow sense heritability and on genetic correlations between flowering, agronomic quality and nutritional quality traits have to be considered in intrapopulation breeding and in intrapopulational recurrent selection.
Association between the Prognostic Nutritional Index and Dietary Intake in Community-Dwelling Older Adults with Heart Failure: Findings from NHANES III

The objective of this study was to examine the association between nutritional status and dietary intake in community-dwelling older adults with heart failure (HF). A cross-sectional analysis of NHANES III data was conducted. The analytic sample was comprised of n = 445 individuals aged 50+ years with congestive HF (54.4% male, 22.9% non-Hispanic Black, 43.8% low-income). Nutritional status was measured using the Prognostic Nutritional Index (PNI). Participants were classified by PNI quintiles with lower PNI scores indicating lower nutritional status. Participants in quintile 5 showed significantly greater intakes of energy, protein, vegetables, magnesium, zinc, copper, potassium, red meat, saturated fat, and sodium. In multivariate analyses, increased intake of red meat (β = 0.253, p = 0.040) and vegetables (β = 0.255, p = 0.038) was associated with significantly better nutritional status. In the absence of comprehensive nutritional guidance for HF patients, it appears that small increases in energy, protein (red meat), and vegetable consumption are associated with improved nutritional status.
Numerical Tracking of Limit Points for Direct Parametric Analysis in Nonlinear Rotordynamics

A frequency-domain approach for direct parametric analysis of limit points of nonlinear dynamical systems is presented in this paper. Instead of computing responses curves for several values of a given system parameter, the direct tracking of limit points is performed. The whole numerical procedure is based on the Harmonic Balance Method and can be decomposed in three distinct steps. Firstly, a response curve is calculated by HBM combined with a continuation technique until a limit point is detected. Then this starting limit point is used to initialize the direct tracking of limit points which is based on the combination of a so-called extended system and a continuation technique. With only one computation, a complete branch of limit points is obtained, which provides the stability boundary with respect to system parameters such as nonlinearity or excitation level. Several numerical examples demonstrate the capabilities and the performance of the proposed method.
Viscosity, pressure and support of the gas in simulations of merging cool-core clusters

Major mergers are considered to be a significant source of turbulence in clusters. We performed a numerical simulation of a major merger event using nested-grid initial conditions, adaptive mesh refinement, radiative cooling of primordial gas, and a homogeneous ultraviolet background. By calculating the microscopic viscosity on the basis of various theoretical assumptions and estimating the Kolmogorov length from the turbulent dissipation rate computed with a subgrid-scale model, we are able to demonstrate that most of the warm-hot intergalactic medium can sustain a fully turbulent state only if the magnetic suppression of the viscosity is considerable. Accepting this as premise, it turns out that ratios of turbulent and thermal quantities change only little in the course of the merger. This confirms the tight correlations between the mean thermal and non-thermal energy content for large samples of clusters in earlier studies, which can be interpreted as second self-similarity on top of the self-similarity for different halo masses. Another long-standing question is how and to which extent turbulence contributes to the support of the gas against gravity. From a global perspective, the ratio of turbulent and thermal pressures is significant for the clusters in our simulation. On the other hand, a local measure is provided by the compression rate, i.e. the growth rate of the divergence of the flow. Particularly for the intracluster medium, we find that the dominant contribution against gravity comes from thermal pressure, while compressible turbulence effectively counteracts the support. For this reason it appears to be too simplistic to consider turbulence merely as an effective enhancement of thermal energy.
Model cohesive powders : assembling process and plastic consolidation

Discrete element simulations are used to investigate the as s mbling and the plastic consolidation behavior of model cohesive powders which consist of two-dimensional aggrega tes of disks. The material state varies with a reduced pressureP ∗ comparing the confining pressure to the maximum tensile cont a t force, and sensitively depends on the assembling process. If ininitially a continuous struct ure has formed before the confining stress is applied, loose configurations are obtained, with the fractal dimension of b allistic aggregation clusters characterizing density correlations on scales between the grain size and a certain b lob sizeξ. The coordination number varies with the initial agitation velocity and with the resistance to rolli ng in contacts. Under growing P , the system undergoes an irreversible collapse similar to the plastic consolidatio n f clays and powders in which the characteristic size ∼ ξ of the larger pores decreases and the microstructure of cohe si nless granular assemblies is gradually recovered.