Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis

Background Previous studies on the diagnostic value of arterial calcium stimulation with hepatic venous sampling (ASVS) for the localization of insulinoma have reported inconsistent results. Here, we performed a meta-analysis of the relevant published studies. Methods PubMed, Embase, Web of Science, the Cochrane Library, and Wanfang Data were searched for studies on the diagnostic value of ASVS in insulinoma localization published up to May 2019. We calculated the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and receiver operating characteristic (ROC) curve of ASVS in the localization of insulinoma. Results We included ten studies involving 337 patients in the study. The pooled sensitivity, specificity, PLR, and NLR were 0.93 (95% confidence interval [CI]: 0.83–0.97), 0.86 (95%CI: 0.75–0.93), 6.8(95%CI: 3.7–12.7), and 0.08 (95%CI: 0.03–0.19), respectively. The DOR was 84 (95%CI: 30–233), and the area under the ROC curve was 0.96 (95%CI: 0.94–0.97). The results of the heterogeneity of the studies (P = 0.00, I2 = 80.17) were calculated using forest plots of the DOR. Conclusion ASVS is of significant value in localization of insulinoma. If a qualitative diagnosis of insulinoma is definite and the imaging examination results are negative, ASVS should be performed to confirm the localization of insulinoma.
Occupational co‐exposure to biomechanical factors and neurotoxic chemicals in a representative sample of French employees

Musculoskeletal disorders, mainly carpal tunnel syndrome, represent a leading cause of compensation claims of workers worldwide. Despite this, and the fact that occupational exposures to biomechanical factors and neurotoxic chemicals have been individually associated with peripheral nerve damage, the prevalence of occupational co‐exposure to biomechanical factors and neurotoxic chemicals has rarely been explored. Therefore, our aim was to assess the prevalence of occupational co‐exposure to biomechanical factors and neurotoxic chemicals in a national representative sample of the French working population.
Amniotic fluid levels of selected trace elements and heavy metals in pregnancies complicated with neural tube defects

The aims of this study were to determine the levels of trace elements and heavy metals, namely aluminum (Al), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), molybdenum (Mo), cadmium (Cd), tin (Sn), antimony (Sb), mercury (Hg), and lead (Pb), in the amniotic fluid of pregnant women, and to investigate their relationship with neural tube defects (NTDs). The study included 36 pregnant women whose fetuses were complicated with NTDs (study group) and 39 pregnant women with unaffected healthy fetuses (control group), who were matched for body mass index and gestational weeks. The amniotic fluid levels of trace elements and heavy metals were measured using inductively coupled plasma‐mass spectrometry and compared between the two groups. Significantly lower mean levels of Zn and Mo and significantly higher levels of Al, Sn, Sb, and Hg in the study group than in the healthy control group were observed, which implied that these elements are possibly correlated with risk factors for the occurrence of NTDs. In contrast, there were no significant differences in the levels of Cr, Mn, Co, Ni, Cu, As, Cd, and Pb between the groups (P ≥ .05).
Extraction and isolation of the active ingredients of dandelion and its antifungal activity against Candida albicans

In this study, six compounds were isolated and purified from dandelion, and only sample I exhibited notable antifungal effect on Candida albicans (CA). high-performance liquid chromatography-diode-array detector-electrospray ionization-tandem mass spectrometry analysis showed that sample I comprised 4-coumaric acid, ferulic acid, quercetin pentoside, 3,5-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid, luteolin, and two unknown compounds, at a relative percent composition of 11.45, 3.96, 10.48, 34.24, 3.91, 11.80, 3.65 and 4.21%, respectively. Further antimicrobial experiments showed that the minimum inhibitory concentration of sample I was 32.0 mg/ml, and sample I mainly acts on bacterial growth in the exponential phase of CA growth. Optical density and infrared analyses conclusively suggested that sample I damages the structure of CA cells, particularly the cell wall and cell membrane, resulting in macromolecule leakage of intracellular nucleic acids and cell metabolism disruption. In conclusion, dandelion sample I was reported to increase CA cell membrane permeability by affecting the glycosidic bond in β-(1–3)-D glucan and destroying the cell wall, ultimately leading CA to death.
The roles of MRI-based prostate volume and associated zone-adjusted prostate-specific antigen concentrations in predicting prostate cancer and high-risk prostate cancer

Prostate biopsies are frequently performed to screen for prostate cancer (PCa) with complications such as infections and bleeding. To reduce unnecessary biopsies, here we designed an improved predictive model of MRI-based prostate volume and associated zone-adjusted prostate-specific antigen (PSA) concentrations for diagnosing PCa and risk stratification. Multiparametric MRI administered to 422 consecutive patients before initial transrectal ultrasonography-guided 13-core prostate biopsies from January 2012 to March 2018 at Fujian Medical University Union Hospital. Univariate and multivariate logistic regression analyses and determination of the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was performed to evaluate and integrate the predictors of PCa and high-risk prostate cancer (HR-PCa). The detection rates of PCa was 43.84% (185/422). And the detection rates of HR-PCa was 71.35% (132/185) in PCa patients. Multivariate analysis revealed that prostate volume(PV), PSA density(PSAD), transitional zone volume(TZV), PSA density of the transitional zone(PSADTZ), and MR were independent predictors of PCa and HR-PCa. PSA, peripheral zone volume(PZV) and PSA density of the peripheral zone(PSADPZ) were independent predictors of PCa but not HR-PCa. The AUC of our best predictive model including PSA + PV + PSAD + MR + TZV or PSA + PV + PSAD + MR + PZV was 0.906 for PCa. The AUC of the best predictive model of PV + PSAD + MR + TZV was 0.893 for HR-PCa. In conclusion, our results will likely improve the detection rate of prostate cancer, avoiding unnecessary prostate biopsies, and for evaluating risk stratification.
Role of Phosphorylated Tau and Glucose Synthase Kinase 3 Beta in Huntington's Disease Progression.

The purpose of our article is to critically assess the role of phosphorylated tau in Huntington's disease (HD) progression and pathogenesis. HD is a fatal and pure genetic disease, characterized by chorea, seizures, involuntary movements, dystonia, cognitive decline, intellectual impairment, and emotional disturbances. HD is caused by expanded polyglutamine (polyQ or CAG) repeats within the exon 1 of the HD gene. HD has an autosomal dominant pattern of inheritance with genetic anticipation. Although the HD gene was discovered 16 years ago, there is no complete understanding of how mutant huntingtin (mHTT) selectively targets medium spiny projection neurons in the basal ganglia of the brain in patients with HD. Several years of intense research revealed that multiple cellular changes are involved in disease process, including transcriptional dysregulation, mitochondrial abnormalities and impaired bioenergetics, defective axonal transport, calcium dyshomeostasis, synaptic damage and caspase, and NMDAR activations. Recent research also revealed that phosphorylated tau and defective GSK-3β signaling are strongly linked to progression of the disease. This article summarizes the recent developments of cellular and pathological changes in disease progression of HD. This article also highlights recent developments in phosphorylated tau and defective GSK-3β signaling and the involvement of calcineurin in HD progression and pathogenesis.
Individual and socio-demographic determinants of suicide: An examination on WHO countries

Background: Suicide cases have psychological, socio-economic and cultural aspects, and such cases may have catastrophic impacts in societies due to their outcomes. Purpose: This study was aimed to reflect the effect of psychological, behavioral, socio-demographic and economic determinants on suicide. Methods: The Ordinary Least Square (OLS) Regression Analysis was utilized for the purposes of this study. Five models were established. In this contex, the first model includes the variables on psychological determinants; the second model with the variables on behavioral determinants; the third model with the variables on socio-demographic determinants; the fourth model with the variables on economic determinants and finally the fifth model with all of the independent variables. Conclusion: According to the results, the variables of depression prevalence, alcohol consumption and unemployment rates had statistically significant effect on the suicide cases (p < .05). The study’s outcomes are considered to contribute on the evidence-based policy development process.
The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis

Objectives No information exists about whether fetal inflammatory-response(FIR), early-onset neonatal sepsis(EONS) and chorioamnionitis(an advanced-stage of maternal inflammatory-response in extraplacental membranes) continuously increase according to the progression of inflammation in umbilical-cord(UC). The objective of current-study is to examine this-issue. Methods Study-population included 239singleton pregnant-women(gestational-age[GA] at delivery: 21.6~36weeks) who had inflammation in extraplacental membranes or chorionic plate (CP) and either preterm-labor or preterm-PROM. We examined FIR, and the frequency of fetal inflammatory-responses syndrome(FIRS), proven-EONS, suspected-EONS and chorioamnionitis according to the progression of inflammation in UC. The progression of inflammation in UC was divided with a slight-modification from previously reported-criteria as follows: stage0, inflammation-free UC; stage-1: umbilical phlebitis only; stage-2: involvement of at least one UA and either the other UA or UV without extension into WJ; stage-3: the extension of inflammation into WJ. FIR was gauged by umbilical-cord-plasma(UCP) CRP concentration(ng/ml) at birth, and FIRS was defined as an elevated UCP CRP concentration at birth(≥200ng/ml). Results Stage-0, stage-1, stage-2 and stage-3 of inflammation in UC were present in 48.1%, 15.5%, 6.7%, and 29.7% of cases. FIR continuously increased according to the progression of inflammation in UC(Kruskal-Wallis test,P<0.001; Spearman-rank-correlation test,P<0.000001,r = 0.546). Moreover, there was a significant and stepwise increase in the frequency of FIRS, proven-EONS, suspected-EONS and chorioamnionitis according to the progression of inflammation in UC(each for P<0.000005 in both chi-square test and linear-by-linear-association). Multiple logistic-regression analysis demonstrated that the more advanced-stage in the progression of inflammation in UC(i.e., stage-1 vs. stage-2 vs. stage-3), the better predictor of suspected-EONS (Odds-ratio[OR]3.358, 95%confidence-interval[CI]:1.020–11.057 vs. OR5.147, 95%CI:1.189–22.275 vs. OR11.040, 95%CI:4.118–29.592) and chorioamnionitis(OR6.593, 95%CI:2.717–15.999 vs. OR16.508, 95%CI:3.916–69.596 vs. OR20.167, 95%CI:8.629–47.137). Conclusion FIR, EONS and chorioamnionitis continuously increase according to the progression of inflammation in UC among preterm-gestations with inflammation in extraplacental membranes or CP. This finding may suggest that funisitis(inflammation in UC) is both qualitatively and quantitatively histologic-counterpart of FIRS, and a surrogate-marker for chorioamnionitis.
Setting the record straight: System justification and rigidity-of-the-right in contemporary Hungarian politics.

Despite international concern about the resurgence of right-wing authoritarianism and xenophobic prejudice throughout Central and Eastern Europe, researchers have argued recently that rightists may be less cognitively rigid and system-justifying than liberals and leftists in the context of Hungary (Kelemen, Szabó, Mészáros, László, & Forgas, 2014; Lönnqvist, Szabó, & Kelemen, 2019). We identify shortcomings of the research on which these claims are based and provide evidence that "rigidity-of-the-right" does indeed characterise contemporary Hungarian politics. Specifically, we hired professional survey firms to administer measures of personal needs for order and structure, system justification and political orientation to two large, nationally representative samples in Hungary. Results revealed that self-identified rightists scored higher than leftists on needs for order and structure and system justification (Study 1, N = 1005) and that supporters of right-wing parties (Fidesz and Jobbik) scored higher on both general and economic system justification than supporters of liberal and leftist parties (Study 2, N = 886). In exploratory analyses, we also observed that rightists expressed more intolerance than leftists toward groups that are commonly mistreated in Eastern Europe, including the Roma, religious minorities and sexual minorities.
Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice

Caloric restriction has been associated with increased life span and reduced aging-related disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of excess fibrous material in tissues and organs and is caused by aging, chronic stress, injury, or disease. Myofibroblasts are fibroblast-like cells that secrete high levels of extracellular matrix proteins, resulting in fibrosis. Histological studies have identified many-fold increases of myofibroblasts in aged organs where myofibroblasts are constantly generated from resident tissue fibroblasts and other cell types. However, it remains unclear how aging increases the generation of myofibroblasts. Here, using mouse models and biochemical assays, we show that sirtuin 6 (SIRT6) deficiency plays a major role in aging-associated transformation of fibroblasts to myofibroblasts, resulting in tissue fibrosis. Our findings suggest that SIRT6-deficient fibroblasts transform spontaneously to myofibroblasts through hyperactivation of transforming growth factor β (TGF-β) signaling in a cell-autonomous manner. Importantly, we noted that SIRT6 haploinsufficiency is sufficient for enhancing myofibroblast generation, leading to multiorgan fibrosis and cardiac dysfunction in mice during aging. Mechanistically, SIRT6 bound to and repressed the expression of key TGF-β signaling genes by deacetylating SMAD family member 3 (SMAD3) and Lys-9 and Lys-56 in histone 3. SIRT6 binding to the promoters of genes in the TGF-β signaling pathway decreased significantly with age and was accompanied by increased binding of SMAD3 to these promoters. Our findings reveal that SIRT6 may be a potential candidate for modulating TGF-β signaling to reduce multiorgan fibrosis during aging and fibrosis-associated diseases.
Important factors in left atrial posterior wall isolation using 28‐mm cryoballoon ablation for persistent atrial fibrillation—Block line or isolation area?

Left atrial (LA) roof ablation using the cryoballoon technique, combined with pulmonary vein isolation (PVI), has been reported to be beneficial for ablation therapy in patients with persistent atrial fibrillation (AF). Left posterior wall ablation also results in improved patient outcomes. However, the contribution of these techniques to the success of cryoballoon ablation (CBA) treatment of AF is not known. The present study examined the influence of the roofline block and isolation area on outcomes after CBA.
Poikilodermatous mycosis fungoides with CD30‐positive large cell transformation successfully treated by brentuximab vedotin

We present a patient with a 33‐year history of poikilodermatous mycosis fungoides (MF) who subsequently developed CD30‐positive large cell transformation. After 6 years of conventional MF treatment, side effects of therapy and/or concomitant diseases prevented the previously applied treatment modalities. The CD30‐directed antibody‐cytotoxic drug conjugate (brentuximab vedotin) was introduced and followed by quick and excellent therapeutic response.
Novel Insect Antifeedant and Ixodicidal Nootkatone Derivatives

Naturally occurring nootkatone, with reported insecticidal and acaricidal properties, has been used as a lead to generate molecular diversity and, consequently, new insect antifeedant and ixodicidal compounds. A total of 22 derivatives were generated by subjecting this molecule to several reactions including dehydrogenation with the iodine/DMSO system, oxidation with SeO2, epoxidation with mCPBA, oxidation or carbon homologations of the α-carbonyl position with TMSOTf (trimethylsilyl trifluoromethanesulfonate) followed by Rubottom and Dess Martin periodane oxidations, condensation with formaldehyde using Yb(OTf)3 as catalyst and dehydroxilation using the Grieco protocol. The insect antifeedant (against Myzus persicae and Ropaloshysum padi) and ixodicidal (against the tick Hyalomma lusitanicum) activities of these compounds were tested. Compound 20 was the most active substance against M. persicae and R. padi, and twice more efficient than nootkatone in the antitick test.
Advantage and use of S-patch cardio solution in competitive motor sports1.

BACKGROUND Motorsport karting has developed into a professional international competition. Kart racing poses a unique set of physiologic challenges for athletes who compete in this sport. Until today no major study has evaluated the physical and cardiac challenge in professional kart racing. OBJECTIVE The aim for this study was to measure and analyze heart rate and cardiac rhythm by a mobile, smartphone based ECG (s-patch) on professional kart-race-drivers during actual karting races through annual seasons to test the hypotheses that high g-force and stress could trigger cardiac arrhythmia. MATERIAL AND METHODS ECG-data from kart-drivers were acquired during local races, the ADAC Kart-Masters (KZ2), the German Kart Championship (DSKC) and the European Championship Senior CIK-FIA-Serie and analyzed in this observational study. In total, free practice, qualifying practice and 32 races were assessed during the kart season 2019. Data were interpreted by two independent experienced physicians. RESULTS The average heart rate (HR) during a selected German Kart Championship (DSKC) race in Genk (Belgium) was 169 beats min-1. The longest R-R interval was 0.72 sec. The average HR during a selected European Championship CIK-FIA-race in Lonato (Italy) was 160 beats min-1. The longest R-R interval was 0.74 sec. The average HR during a selected ADAC Kart-Masters (KZ2) races in Wackersdorf (Germany) was 147 beats min-1. The longest R-R interval was 0.86 sec. In total 32 races could be recorded successful. No couplets or bigeminy cycles were detected. In one other kart racer a supraventricular extrasystole and a ventricular extrasystole was detected. Interestingly, kart-drivers were found to have sinustachycardia throughout the races most likely triggered by emotional and physiological stress during speeding. CONCLUSION Professional kart racing drivers had sinustachycardia with heart rates up to 193 beats min-1 during races. This is most likely attributed to a considerably high emotional and physiological stress affecting the cardiovascular system. Episodes of tachycardia positively correlated with mean speed. In the warm-up lap the heart rate was significantly lower in comparison to the race, suggesting that faster driving speed would induce greater cardiovascular stress to professional drivers during actual races. The experimental results showed that the proposed S-patch system provided a good ECG signal quality with accurate measurements even during the kart race and could detect the ECG features of the race in real time. The cardiac interpretation software performs well and is a useful tool to assist clinicians.
How does MobileMums work? Mediators of a physical activity intervention

Abstract Objectives: To establish which Social Cognitive Theory constructs mediated effects of the MobileMums (MMP) program on increased duration and frequency of moderate-vigorous physical activity (MVPA) in women with young children (<5 years). Methods: This secondary data analysis is from a community-based randomised controlled trial. Over 12 weeks, intervention participants received a minimum of 52 individually tailored text messages, one face-to-face and one telephone-delivered session with a trained behavioural counsellor. Participants identified a support person who also received 12 weeks of individually tailored text messages. Control participants received minimal intervention contact. Data were collected pre- and post-program. Five potential mediators were assessed: barrier self-efficacy, goal setting skills, outcome expectancies, perceived environmental opportunity for physical activity and social support for physical activity. Results: Improvements in MVPA frequency were mediated by improvements in barrier self-efficacy, goal setting skills, outcome expectancies and perceived social support. Improvements in MVPA duration resulting from the MMP were mediated by improvements in women’s barrier self-efficacy and goal setting skills. Conclusions: MMP improved targeted theoretical constructs and this led to changes in women’s MVPA. These findings are valuable for refinement and translation of the MMP and for further research to create theory- and evidence-based physical activity behaviour change programs for women with young children.
Prevalence of multi, extensively and pan drug resistant uropathogens among the women patients visiting a tertiary care hospital in central India

Background: The escalation of drug resistance among the uropathogens poses a global threat. The indiscriminate, inadequate and the irrational usage of antimicrobials have contributed to the emergence of resistant strains, which may turn out to be a leading cause for the morbidity and mortality in the developing countries. Aims: The aim of the study was to provide an outlook on the prevalence of drug resistance among the isolated uropathogens. Subjects and Methods: The present study was carried out in the department of Microbiology of a teaching tertiary care hospital from July 2013 to September 2013. A total of 314 urine samples were tested, out of which 115 samples were culture positive. All the uropathogenic isolates were identified up to species level by conventional methods. Antibiotic sensitivity testing was done through disc diffusion method and all interpretations were done in accordance with the Clinical and Laboratory Standards Institute (CLSI)-2013 guidelines. Simultaneously, the extended-spectrum beta-lactamases (ESBL), Amp C and carbapenemase production mechanisms were also detected among the various isolates. Antibiotic resistance profile of the various Gram negative isolates was evaluated and the percentage prevalence of multi drug resistant(MDR), extensively drug resistant(XDR) and pan drug resistant(PDR) isolates was determined. Results: Out of the 314 urine samples tested, 120 isolates were detected among which 91 isolates were Gram negative bacilli. Among the 91 Gram negative isolates, 69 (75.8%) were MDR, 11 (12%) were XDR whereas 2 (2.1%) were PDR isolates. Conclusions: Before prescribing an empirical anti microbial therapy, an in depth knowledge of the etiology, the predisposing factors, the culture positivity and the continued evaluation of the susceptibility patterns of the uropathogens to the traditional as well as new antimicrobials is essential to avoid irrational drug usage and to ascertain the optimal prophylactic therapy.