Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Test Administration Order on Children's Neuropsychological Performance: Emerging One-word Expressive and Receptive Language Skills

Differences in neuropsychological performance associated with specific test presentation sequences have been reported in adults. However, these effects have received little attention in children. The EOWPVT-R, a measure of one-word expressive language, and the PPVT-R, a measure of receptive language, were administered to 6- to 14-year-olds (control [n = 17] and experimental [n = 22] groups) in a counterbalanced fashion to investigate the potential effects of test presentation sequence on neuropsychological performance. Group findings were not evidenced subsequent to variation in test administration sequence. In contrast, order of test presentation revealed differences in performance. Administration of the PPVT-R prior to the EOWPVT-R resulted in enhanced EOWPVT-R expressive language scores in both groups of participants. Presentation of the PPVT-R after the EOWPVT-R did not affect performance. Applied and theoretical implications associated with these findings are discussed.
Chlamydia Antibodies, Chlamydia Heat Shock Protein, and Adverse Sequelae After Pelvic Inflammatory Disease: The PID Evaluation and Clinical Health (PEACH) Study

Background: Among women with pelvic inflammatory disease (PID), we assessed the associations among antibodies to Chlamydia trachomatis elementary bodies (EB), antibodies to chlamydia heat shock protein (Chsp60), rates of pregnancy, and PID recurrence. Methods: Four hundred forty-three women with clinical signs and symptoms of mild to moderate PID enrolled in the PID Evaluation and Clinical Health Study were followed for a mean of 84 months for outcomes of time-to-pregnancy and time-to-PID recurrence. Antibodies to EB and Chsp60 were assessed in relation to these long-term sequelae of PID. Results: Rates of pregnancy were significantly lower (adj. hazard ratio 0.47, 95% confidence interval 0.28–0.79) and PID recurrence higher (adj. hazard ratio 2.48, 95% confidence interval 1.00–6.27) after adjusting for confounding factors among women whose antibody titers to chlamydia EB measured in the final year of follow-up were in the highest tertile. Conclusion: Among women with mild to moderate PID, antibodies to C. trachomatis were independently associated with reduced rates of pregnancy and elevated rates of recurrent PID.
Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc

The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by replicating selected results from a substantial number of high-profile papers in the field of cancer biology published between 2010 and 2012. This Registered report describes the proposed replication plan of key experiments from ‘BET bromodomain inhibition as a therapeutic strategy to target c-Myc’ by Delmore and colleagues, published in Cell in 2011 (Delmore et al., 2011). The key experiments that will be replicated are those reported in Figures 3B and 7C-E. Delmore and colleagues demonstrated that treatment with JQ1, a small molecular inhibitor targeting BET bromodomains, resulted in the transcriptional down-regulation of the c-Myc oncogene in vitro (Figure 3B; Delmore et al., 2011). To assess the therapeutic efficacy of JQ1 in vivo, mice bearing multiple myeloma (MM) lesions were treated with JQ1 before evaluation for tumor burden and overall survival. JQ1 treatment significantly reduced disease burden and increased survival time (Figure 7C-E; Delmore et al., 2011). The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange and the results of the replications will be published in eLife. DOI: http://dx.doi. org/10.7554/eLife.07072. 001
Hittite Cult Inventories – Part Two: The Dating of the Texts and the Alleged ‘Cult Reorganization’ of Tudḫaliya IV

Abstract The Hittite cult inventories constitute a corpus of ca. 550 fragments dating to the Late Empire period, dealing with local offerings and festivals in provincial towns. They are commonly viewed against the background of an assumed reorganization of local cults promoted by Tudḫaliya IV. Within such an extensive operation, local festivals would have been restyled and standardized to some degree. The paper aims at casting doubts on these assumptions, presenting a reappraisal of the questions concerning the dating of the texts and a minimalist interpretation of Tudḫaliya’s ‘cult reorganization’. It also provides an overview of the extant Middle Hittite fragments and on restorations of local cults pre-dating Tudḫaliya IV. The main conclusions are that (1) the arguments behind the assumption that the majority of the surviving fragments should be dated to Tudḫaliya IV are debatable; (2) the measures taken by Tudḫaliya reflect practices that are attested from at least the Middle Hittite period, without any substantial innovation; and (3) despite their stylistic similarities, the texts tend to treat the local festivals, the origins of which in all likelihood go back to ancestral times, in a faithful way.
Adsorption of water in activated carbons: Effects of pore blocking and connectivity

We present a simulation study of the adsorption mechanism of water in a realistic carbon structure. Water molecules are modeled using a recently developed fixed-point charge water model optimized to the vapor−liquid coexistence properties.1 Reverse Monte Carlo techniques2 are used to generate a realistic porous carbon model composed of graphitic microcrystals consisting of rigid basal plates. Arrangements of the carbon plates are driven by a systematic refinement of simulated carbon−carbon radial distribution functions to match experimentally measured radial distribution functions. The adsorption of water in activated (having oxygenated surface groups) and nonactivated (graphitic) carbon is investigated using the grand canonical Monte Carlo simulation method. The adsorption behavior is found to be strongly dependent on the presence of activated sites. No appreciable adsorption occurs in the graphitic carbon until the pressure approaches the bulk gas saturation pressure. Effects of the surface site density.
Soil radionuclide concentrations and radiological assessment in and around a refining and petrochemical company in Warri, Niger Delta, Nigeria

Radioactivity measurements have been carried out using gamma-ray spectroscopy to determine the radionuclide concentrations in soil samples in the premises of the Warri Refining and Petrochemical Company located in the Niger Delta region of Nigeria and also in communities around it. The radionuclide contents of the crude oil and petroleum additives were also similarly determined. Results indicate that on the premises used by the company, the ranges of activity concentrations of 40K, 226Ra and 228Th in the soil samples were 261.3–932.3 Bq kg−1,<4.2–23.0 Bq kg−1 and<5.1–10.2 Bq kg−1, respectively. For the 13 villages studied, activity concentrations ranged from <17.2–766.3 Bq kg−1,<4.2–104.7 Bq kg−1 and<5.1–13.7 Bq kg−1, respectively, for 40K, 226Ra and 228Th. The lowest radionuclide concentrations were found in the crude oil relative to the petroleum additives. The highest outdoor effective dose rate obtained in the study was 47.5 µSv y−1 for the villages and 35.2 µSv y−1 within the company premises. These values are less than the world average outdoor value of 70 µSv y−1 given by UNSCEAR. Overall, it can be concluded that the long duration of refining activities does not seem to have affected radionuclide concentrations in the environment. Measurements also showed that the observed radiation dose rates did not vary significantly from the previously determined Warri City outdoor gamma radiation dose rates, for which the probability of occurrence of any health effects of radiation was judged low. The measurements, therefore, are interpreted to represent baseline radiometric data for future reference and research in the area.
Predicting College Math Success: Do High School Performance and Gender Matter? Evidence from Sultan Qaboos University in Oman.

The objective of this study was to evaluate the performance of students of college of Science of Sultan Qaboos University (SQU) in Calculus I course, and examine the predictive validity of student’s high school performance and gender for Calculus I success. The data for the study was extracted from students’ database maintained by the Deanship of Admission and Registration office of SQU. The study considered a sample of 615 students who took Calculus I course during 2014 spring semester. Both descriptive and inferential statistical techniques were used for data analysis. Predictive validity of selected factors were analyzed using Hierarchical regression analysis. The analysis revealed that female students entered in SQU with a higher average high school scores than male students, and many boys with lesser high school scores than girls were succeeded in getting admission at SQU. The results indicate that female students outperformed male students in both high school and college Calculus course. About 30% of the students obtained grades lower than C in Calculus I, of which 20% failed in the course. The proportion of students with F grade was found to be significantly higher among male students compared to female students (28% vs. 7%). The analysis revealed that gender, high school math score and overall high school score are significant predictors of subsequent performance in Calculus course at college level. Thus differences among gender and high school performance should be taken into consideration during the admission process to allow for more equal opportunities to all applicants and have fairer admission decisions.
A Neural Network Approach for Automatic Detection of Acoustic Alarms

Acoustic alarms generated by biomedical equipment are relevant sounds in the noisy Neonatal Intensive Care Unit (NICU) environment both because of their high frequency of occurrence and their possible negative effects on the neurodevelopment of preterm newborns. This work addresses the detection of specific alarms in that difficult environment by using neural network structures. Specifically, both generic and class-specific input models are proposed. The first one does not take advantage of any specific knowledge about alarm classes, while the second one exploits the information about the alarm-specific frequency sub-bands. Two types of partially connected layers were designed to deal with the input information in frequency and in time and reduce the network complexity. The time context was also considered by performing experiments with long short-term memory networks. The database used in this work was acquired in a real-world NICU environment. The reported results show an improvement of more than 9% in absolute value for the generic input model and more than 12% for the class-specific input model, when both consider time information using the proposed partially connected layer.
Frequency effects in the written and spoken production of homophonic picture names

In Experiment 1, participants had to write down or to speak aloud the names of either high frequency (HF) or low frequency (LF) heterographic homophonic picture targets. The most important finding was that HF targets took less time to initialise than LF targets in both spoken and written production. In Experiment 2, participants had to categorise the same picture targets as "artificial" or "naturally occurring" objects. LF homophonic targets were categorised faster than HF ones. The findings offer no support for the claim made by Jescheniak and Levelt (1994) that low frequency word homophones inherit a processing advantage from their higher frequency mates. The implications of the findings for interpretation of the locus of word frequency effects in language production are discussed.
Is Ace Inhibitor Treatment a Possible Cause of Better Cardiovascular Remodelling in Well Functioning Kidney Transplant?

Diseases of the cardiovascular system are a common cause of death in renal transplanted patients. In this study we assessed the echocardiographic morphological and functional findings after renal transplantation of two homogenous groups of transplanted patients with normal renal function. The first (A) with spontaneously normotensive patients, the second (B) with moderate hypertension treated mainly with Ace inhibitors. Analysis of these data highlights two noteworthy results: the similar left ventricle hypertrophy found in both groups and the existence of better diastolic compliance among the hypertensive transplanted patients. If this is confirmed by studies currently in progress, the importance of Ace-inhibitors treatment in remodelling cardiac dysfunction after long term dialysis treatment might be seriously considered.
Automatic speech recognition and training for severely dysarthric users of assistive technology: The STARDUST project

The STARDUST project developed robust computer speech recognizers for use by eight people with severe dysarthria and concomitant physical disability to access assistive technologies. Independent computer speech recognizers trained with normal speech are of limited functional use by those with severe dysarthria due to limited and inconsistent proximity to “normal” articulatory patterns. Severe dysarthric output may also be characterized by a small mass of distinguishable phonetic tokens making the acoustic differentiation of target words difficult. Speaker dependent computer speech recognition using Hidden Markov Models was achieved by the identification of robust phonetic elements within the individual speaker output patterns. A new system of speech training using computer generated visual and auditory feedback reduced the inconsistent production of key phonetic tokens over time.
MicroRNA profiling for the identification of cancers with unknown primary tissue‐of‐origin

Cancer of unknown primary (CUP) represents a common and important clinical problem. There is evidence that most CUPs are metastases of carcinomas whose primary site cannot be recognized. Driven by the hypothesis that the knowledge of primary cancer could improve patient's prognosis, we investigated microRNA expression profiling as a tool for identifying the tissue of origin of metastases. We assessed microRNA expression from 101 formalin‐fixed, paraffin‐embedded (FFPE) samples from primary cancers and metastasis samples by using a microarray platform. Forty samples representing ten different cancer types were used for defining a cancer‐type‐specific microRNA signature, which was used for predicting primary sites of metastatic cancers. A 47‐miRNA signature was identified and used to estimate tissue‐of‐origin probabilities for each sample. Overall, accuracy reached 100% for primary cancers and 78% for metastases in our cohort of samples. When the signature was applied to an independent published dataset of 170 samples, accuracy remained high: correct prediction was found within the first two options in 86% of the metastasis cases (first prediction was correct in 68% of cases). This signature was also applied to predict 16 CUPs. In this group, first predictions exhibited probabilities higher than 90% in most of the cases. These results establish that FFPE samples can be used to reveal the tissue of origin of metastatic cancers by using microRNA expression profiling and suggest that the approach, if applied, could provide strong indications for CUPs, whose correct diagnosis is presently undefined. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Isoforms of steroid receptor co‐activator 1 differ in their ability to potentiate transcription by the oestrogen receptor

Steroid receptor co‐activator (SRC1) is one of a number of transcriptional co‐activators that are capable of potentiating the activity of nuclear receptors including the oestrogen receptor (ER). Here we report that two isoforms, SRC1a and SRC1e, which diverge at their C‐termini, are functionally distinct as they differ in their abilities to enhance the activity of the ER in intact cells. SRC1e enhanced the ability of the ER to stimulate transcription to a greater extent than SRC1a, which had negligible effects on certain promoters. To elucidate the basis of this functional difference, we compared the nuclear receptor‐binding properties and mapped the transcriptional activation domains in the two SRC1 isoforms. Both isoforms share a triplet of nuclear receptor‐binding motifs (LXXLL motifs) for binding to functional ER dimers, and an activation domain which co‐localizes with the CBP‐binding domain, while SRC1a contains a unique LXXLL motif in its C‐terminus. Although this LXXLL motif increases the affinity for the ER in vitro, it does not appear to be responsible for the functional difference between the two isoforms. This difference is due to a second activation domain that is CBP independent and is suppressed in the SRC1a isoform. Thus, SRC1 exists as functionally distinct isoforms which are likely to play different roles in ER‐mediated transcription.
Non-fatal Occupational Injuries among Non-governmental Employees in Malaysia

Abstract We analyzed data on non-fatal occupational injuries reported to Malaysia's social security organization from 2002 to 2006. There was a decrease in both the absolute number and the incidence rates of these injuries over time. About 40% of cases occurred in the manufacturing sector followed by the service (17%) and trading (17%) sectors. The agriculture sector reported the highest incidence rate (24.1/1,000), followed by the manufacturing sector subcategories of wood-product manufacturing (22.1/1,000) and non-metallic industries (20.8/1,000). Men age 40 to 59 and persons of Indian ethnicity had a greater tendency to sustain injuries. Government and non-governmental organizations should strive to develop strategies to reduce the occupational injuries targeting vulnerable groups. Enforcement of safety measures will further play an important role to ensure that both employees and employers take special precautions to address workplace hazards.
Lipoxins in asthma: potential therapeutic mediators on bronchial inflammation?

Arachidonic acid metabolism represents an important source of mediators with ambivalent actions. Among these, lipoxins (LXs) are the first agents identified and recognized as anti‐inflammatory endogenous lipid mediators, which are involved in the resolution of inflammation and are present in the airways of asthmatic patients. Lipoxins result mainly from the interaction between 5 and 15‐lipoxygenases (LO) and their levels are modulated by the degree of bronchial inflammation as well as by the long‐term glucocorticoid treatments. In the airways, LX synthesis is higher in mild asthmatics than in severe asthmatics, whereas in vitro chemokine release inhibition by LXs is more effective in cells from severe asthmatics than from mild asthmatics. LipoxinA4 effects on interleukin (IL)‐8 released by blood mononuclear cells and on calcium influx in epithelial cells are mediated by the specific receptor ALX. Lipoxin generation by lung epithelial cells depends mainly on 15‐LO activity. Mild asthmatics present higher 15‐LOb expression at the epithelium level than severe patients, whereas the LX deficit in severe asthma is associated with an up‐regulation of the 15‐LOa expressions. Therefore, bronchial epithelial cells become a target for therapeutic intervention and LXs represent a potential therapeutic solution for bronchial inflammation resolution in asthma.
THE BOUNDEDNESS OF CLASSICAL OPERATORS ON VARIABLE L p SPACES

We show that many classical operators in harmonic analysis|such as maximal operators, singular integrals, commutators and fractional integrals|are bounded on the variable Lebesgue space L p( ) whenever the Hardy{Littlewood maximal operator is bounded on L p( ) . Further, we show that such operators satisfy vector-valued inequalities. We do so by applying the theory of weighted norm inequalities and extrapolation. As applications we prove the Calder on{Zygmund inequality for solutions of 4u = f in variable Lebesgue spaces, and prove the Calder on extension theorem for variable Sobolev spaces.
Metabolic and biochemical factors associated with urinary calculi in children : an experience of 100 cases

1 Senior Resident, Department of Paediatrics, SHKM Govt. Medical College, Nuh, Haryana, India 2 Assistant Professor, Department of Internal Medicine, SHKM Govt. Medical College, Nuh, Haryana, India 3 Assistant Professor, Department of Community Medicine, SHKM Govt. Medical College, Nuh, Haryana, India 4 Resident, Department of Nephrology, Sri Aurobindo Medical College & Postgraduate Institute, Madhya Pradesh, India
ABCC2 (1249G > A) polymorphism implicates altered transport activity for sorafenib

Abstract 1. Multidrug resistance-associated protein 2 (MRP2), encoded by the ABCC2 gene, is an efflux transporter of several endogenous substrates and xenobiotics. Here, we investigated whether the 1249G > A (rs2273697) polymorphism in ABCC2 affects the ability of MRP2 to pump the multi-tumor drug sorafenib out of cells. 2. Human embryonic kidney 293 (HEK 293) cell lines transfected with ABCC2-1249G and ABCC2-1249A were used to assess the sensitivity and accumulation to sorafenib. The isolated MRP2 were applied to estimate the ATPase activity. 3. The HEK293 cell line overexpressing the ABCC2 1249A allele showed a significantly higher 50% inhibitory concentration (IC50) than a cell line overexpressing ABCC2-1249G or a non-overexpressing control cell line. Intracellular accumulation of sorafenib was much lower in ABCC2-1249A cells than in ABCC2-1249G cells expressing comparable levels of MRP2. Isolated ABCC2-1249A protein showed higher ATPase activity than ABCC2-1249G protein. 4. Our results suggest that the ABCC2 polymorphism 1249G > A increases the ATPase activity of MRP2, leading to greater efflux of sorafenib.
Affordable Care Act Provision Had Similar, Positive Impacts For Young Adults With And Without Disabilities.

Beginning in 2010 the Affordable Care Act (ACA) allowed young adults (ages 19-25) to remain on their parents' private health insurance plans, even if they were not full-time students. This study investigated the impact of the ACA on health insurance coverage for young adults with disabilities, comparing their experience with that of young adults without disabilities and that of a group of older adults (ages 26-34) with disabilities. We analyzed the periods 2006-09 and 2011-14, which were before and after implementation of the dependent coverage provision in the ACA, respectively. Coverage gains for older adults with disabilities were entirely attributable to changes in public insurance. Gains for young adults overall were driven by changes in private insurance. Both young adults with and without disabilities experienced a 4-percentage-point increase in private health insurance coverage between the two time periods, so the gap in private coverage between the two groups did not change significantly over time. Gains in coverage affected perhaps 2.9 million young adults overall and nearly 300,000 young adults with disabilities.
The ACPE Supervisory Education Process: An Historical Perspective

As the number of Clinical Pastoral Education students increases, supervisors in the Association for Clinical Pastoral Education (ACPE) are in short supply due to retirements. We explore factors associated with this supply problem, reporting here four results from our survey of active and retired supervisors. We identify the ages of the current supervisory pool, the ages at which supervisors were certified and the length of time spent in the supervisory education program across the decades. The survey results also identify what supervisors perceive as the most helpful components of their supervisory education. These four results identify trends across the decades that may be associated with the present and future shortages of supervisors.