Miracle-dz/UniFAR-FTUs huggingface dataset:
Medical insurance, socioeconomic status, and age of onset of endstage renal disease in patients with lupus nephritis.

OBJECTIVE Limited access to care may hasten progression to endstage renal disease (ESRD) in patients with lupus nephritis. We examined associations between type of medical insurance, socioeconomic status (SES), and age at onset of ESRD in a national, population-based cohort. METHODS Using the United States Renal Data System, incident cases of ESRD due to lupus nephritis in the US from January 1, 1996, to June 30, 2004, were examined in this cross-sectional study (n = 7971). Age at onset of ESRD was compared among patients with different types of medical insurance and by SES. RESULTS In each ethnic group, patients with private insurance were older at the onset of ESRD than those with no insurance or Medicaid. For example, whites with private insurance were on average 7.5 years older than those with no insurance and 8.2 years older than those with Medicaid. There were no differences in age at onset of ESRD between those with no insurance and those with Medicaid. SES, based on the socioeconomic characteristics of the patient's area of residence, was associated with age of onset of ESRD only in whites. CONCLUSION Among patients with lupus nephritis who develop ESRD, those with private medical insurance are older when they begin ESRD treatment than those with Medicaid or no insurance. Given that medical insurance is unrelated to the age at onset of lupus nephritis, these findings suggest that progression to ESRD varies with medical insurance status, possibly because of differences in quality of care or access to care.
Spatial & temporal variability of sibilants in children with Down's syndrome

This paper presents findings from EPG analysis of word initial /s/ and /ʃ/ in twenty five children with Down’s syndrome (DS) and ten cognitively age-matched typically developing children (TD). Spatial and temporal variability measures show evidence of increased variability in all attempts of target /s/ and /ʃ/ for the speakers with DS. The findings also show evidence of high levels of spatial variability in children with DS and typically developing children in perceptually acceptable productions of the target sounds. These findings support previous research that links speech production difficulties in children with DS to impaired speech motor ability.
Runoff and Sediments from Hillslope Soils within a Native American Agroecosystem

Farmers of the Zuni Indian Reservation in New Mexico rely on materials transported from upper watersheds to maintain productivity of some of the oldest agricultural fields in North America. This study determined runoff and sediment production from hillslopes as functions of slope position, soil cover, and rainfall characteristics. Runoff was collected from plots in summit or shoulder [SU], backslope [BS], and footslope [FS] positions and in bare soil, microbiotic crust, oak, juniper, pinyon, and grass cover. In rainfall events that generated runoff, sediment C and N concentrations decreased with total sediment yield, but C/N ratios increased. Carbon/nitrogen ratios were generally lower in sediments from early season events. Backslope plots yielded the most sediment (125 g m -2 ) and the most organic C (2.2 g m -2 ), total N (116 mg m -2 ), and total P (34.2 mg m -2 ), but those from SU plots had the highest concentrations (e.g., 31 g C kg -1 compared with 23 g C kg -1 at BS and FS). Bare soil and microbiotic crust plots yielded the most sediments (441 g m -2 ) and grass the least (107 g m -2 ). Though variable, oak plots yielded more C (32.6 g m -2 ) and N (1.5 g m -2 ) than others, but bare soil and microbiotic crust plots yielded the most P (62.7 and 54.4 mg m -2 , respectively). Slope position, cover type, and rainfall characteristics interact to influence movement and processing of materials responsible for agriculturally, ecologically, and hydrologically important alluvium-derived soils in this semiarid agroecosystem.
From Clinical Research to Clinical Practice: A 4-Year Review of Ziprasidone

ABSTRACT Ziprasidone is a second-generation antipsychotic that received Food and Drug Administration approval in February 2001. It has a unique receptor profile that includes high-affinity antagonist activity at dopamine D2 receptors, inverse agonist activity at serotonin (5-HT)2A receptors, agonist activity at 5-HT1A receptors, and a relatively high affinity for the serotonin and norepinephrine transporters. The 5-HT1A affinity, together with the inhibitory effect on monoamine reuptake, may underlie the hypothesized beneficial effects on comorbid affective and cognitive abnormalities in schizophrenia and schizoaffective disorder. The short-term efficacy of ziprasidone for core positive symptoms of schizophrenia appears to be comparable to other conventional and atypical antipsychotics. The short-term efficacy of ziprasidone in acute mania has been established based on two 3-week, double-blind, placebo-controlled trials. Open-label treatment for up to 52 weeks confirms the sustained efficacy and safety of ziprasidone in bipolar disorder. Maintenance studies in schizophrenia and schizoaffective disorder indicate that long-term ziprasidone therapy is effective in preventing relapse, while maintaining cognitive and psychosocial benefits. The safety database suggests that the overall cardiovascular and cerebrovascular risk associated with ziprasidone is lower than with other atypicals, with notably lower risk of drug-related increases in weight, glucose, or lipids. The data also suggest a modestly increased risk of QTc prolongation that is not dose related or linked to torsades de pointes. Switching to ziprasidone from other atypicals appears to improve both clinical symptoms and metabolic parameters, though more studies are needed to fully characterize these benefits. This monograph summarizes the efficacy, tolerability, and safety of oral ziprasidone in the treatment of schizophrenia, schizoaffective disorder, and bipolar mania.
Avaliação Morfofisiológica da Leucena (Leucaena leucocephala) Submetida a Dois Espaçamentos em Duas Épocas

Foi conduzido um experimento com o objetivo de avaliar a altura dos ramos, numero de brotacoes, diâmetro dos ramos, a producao de MS/ha e composicao bromatologica da leucena submetida a dois espacamentos (1,0 x 1,0 e 1,0 x 0,5 m) em duas epocas de corte (seca e chuvosa), num delineamento inteiramente casualizado com seis repeticoes. Os cortes foram a 50 cm do solo, utilizando um intervalo entre cortes de 90 dias para epoca seca (dois cortes) e 60 dias para epoca chuvosa (tres cortes). O plantio foi realizado por meio de covas em parcelas de 10 x 10 m, com uma area util de 4 m 2 . A analise da variância nao mostrou efeito significativo (P>0,05) para o espacamento e a interacao espacamento/epoca. Houve significância (P
The effects of the mother wavelet for transmission line fault detection and classification

The analysis of fault-induced transients can provide extensive information about the fault type, detection, location, direction, and sustained time. Voltages and currents with fault-induced transients can be properly analyzed by using the wavelet transform. However, the effectiveness of the wavelet analysis is largely influenced by the choice of the mother wavelet. This paper evaluates three different mother wavelets: Daubechies, Symlet, and Coiflet families in order to select the most suitable wavelet applied for fault detection and classification by using the analysis of voltages and currents with fault-induced transients.
Fiber Connections of the Corpus Mamillare in a Percomorph Teleost, Tilapia Oreochromis niloticus

The hypothalamus and perhaps its function appear to be similar among vertebrates. Thus, studying the teleostean hypothalamus could be a good model for understanding common neural circuits and mechanisms retained through the vertebrates. However, connections of the inferior lobe, which is considered the hypothalamus in teleosts, is poorly known. The corpus mamillare (CM) is a nucleus of the inferior lobe named after the mammalian mamillary body based on similarities in external morphology. Afferent connections of the CM have been reported only in cypriniform teleosts. These include projections from the nucleus pretectalis superficialis pars magnocellularis, a nucleus lacking in percomorph teleosts, and projections from the secondary gustatory nucleus. Efferent connections of the CM have not been reported in teleosts. In the present study, the CM and its subdivisions and the connections of these subnuclei were identified in isolated and maintained brains of tilapia Oreochromis niloticus by local DiI and biocytin injection. Afferent connections confirmed by reciprocal injections were from the nucleus diffusus lobi inferioris (NDLI) and the nucleus diffusus tori lateralis (NDTL). Efferent connections of each CM subnuclei were also reciprocally confirmed. These connections were to the area dorsalis pars medialis of the telencephalon, the nucleus ventromedialis (NVM) of the thalamus, the tectum opticum (TO), and the nucleus posterioris periventricularis. Because the NDLI is known to receive gustatory information in tilapia, the CM could relay gustatory inputs to multisensory areas, the TO and NVM, for which there are no current reports regarding gustatory inputs.
Mindfulness-Based Stress Reduction ( MBSR ) as supportive therapy in cancer care : A

Aim To systematically review and critically appraise th evidence on the effectiveness of Mindfulness-Based Stress Reduction (MBSR) for cance r supportive care. Methods A comprehensive search of major biomedical database s including Medline, EMBASE, CINAHL, PsycINFO and the Cochrane Library was condu cted. Specialist complementary and alternative medicine (CAM) databa ses including AMED and CISCOM were also searched. Additionally, efforts we re made to identify unpublished and ongoing research. Relevant research was categor is d by study type and appraised according to study design. Clinical commentaries we re obtained for each study and included in the review. Findings Three randomised controlled clinical trials (RCTs) and seven uncontrolled clinical trials were found. A lack of relevant qualitative research studies was identified. Studies report positive results including improvements in mood, sl eep quality and reductions in stress. A dose-response effect has been observed between prac tice of MBSR and improved
Genus Enhydrobacter Staley et   al. 1987 should be recognized as a member of the family Rhodospirillaceae within the class Alphaproteobacteria

The genus Enhydrobacter, first reported as a member of the family Vibrionaceae, has been placed in the family Moraxellaceae, but as a genus incertae sedis in Bergey's Manual of Systematic Bacteriology 2nd edition. During our taxonomic investigation of Enhydrobacter‐like organisms, we observed that the 16S rRNA sequences of E. aerosaccus‐type strain versions NCIMB 12535T, ATCC 27094 T and CCUG 58314T were very different from the accessible data (accession no. AJ550856). Phylogenetic analysis of our 16S rRNA sequence data revealed that these organisms were located within the family Rhodospirillaceae. The genera Inquilinus, Oceanibaculum, Skermanella and Nisaea were closely related (sequence similarities were 88.3∼87.0%), but Enhydrobacter could be distinguished from these genera by growth characteristics, fatty acid profiles (C19:0 cyclo ω8c; 38.4% C18:1ω7c; 32.2%, and C16:0; 8.9% were major components), in being non‐flagellated, and differing in enzymatic activities, including trypsin and β‐glucosidase. From these data, we conclude that the genus Enhydrobacter should be recognized as an independent genus of the family Rhodospirillaceae within the class Alphaproteobacteria.
A finger or not? Prostate examinations by non-urologists at a South African academic institution.

BACKGROUND According to the South African (SA) National Cancer Registry 2009, prostate cancer is the most commonly diagnosed solid-organ cancer in SA men: the incidence increases at ~3% every year, with 1/26 men developing prostate cancer in their lifetime and five men dying every day. Screening for prostate cancer by performing a digital rectal examination (DRE) adds to the sensitivity and specificity of serum prostate-specific antigen (PSA) testing and is an important component of the assessment for the early detection of prostate cancer. OBJECTIVES To ascertain whether doctors who are not in the field of urology perform DREs and PSA testing to screen for prostate cancer, where indicated, and to determine the reason, if any, why doctors do not perform prostate examinations. METHODS Doctors (including specialists and primary care practitioners) who consulted adult male patients in the emergency departments and polyclinics of three academic hospitals were included in the sample and asked to complete an anonymous questionnaire. Doctors with specialist urological training were excluded from the sample. The questionnaire included the following aspects: gender, year of graduation and university, current position, knowledge of PSA screening and DRE, whether these were being performed, and reasons for non-performance. RESULTS The response rate was 303/350 participants. Fifty-nine percent of the respondents were female. The median duration of experience was 5 years. The mean (standard deviation) knowledge score with regard to screening was 56.1% (20). The PSA test alone was most frequently done (35%), followed by asking the patient about urinary tract symptoms (28%). In contrast, DRE of the prostate, alone or combined with a PSA test, was performed less frequently (13.2% and 10.6%, respectively). Some of the most common reasons for not performing a DRE included: 'It's more convenient to do a PSA test'; 'Urologists will examine the prostate anyway'; 'No privacy in the emergency department/admission ward'; 'Prostate exam is not relevant to my practice'; 'There is not enough time'; and 'The practitioner forgets'. Doctors with >7 years of working experience are the least likely to do a DRE. CONCLUSION Performance rates of DRE and PSA testing by doctors who are not urologists are very low, which may have significant clinical implications. It is recommended that SA prostate cancer screening guidelines are necessary to change practice with regard to this condition.
Naked Dense Bodies Provoke Depression

At presynaptic active zones (AZs), the frequently observed tethering of synaptic vesicles to an electron-dense cytomatrix represents a process of largely unknown functional significance. Here, we identified a hypomorphic allele, brpnude, lacking merely the last 1% of the C-terminal amino acids (17 of 1740) of the active zone protein Bruchpilot. In brpnude, electron-dense bodies were properly shaped, though entirely bare of synaptic vesicles. While basal glutamate release was unchanged, paired-pulse and sustained stimulation provoked depression. Furthermore, rapid recovery following sustained release was slowed. Our results causally link, with intramolecular precision, the tethering of vesicles at the AZ cytomatrix to synaptic depression.
Clinicopathological evaluation of sinunasal neoplasm in a tertiary care hospital

Objective: Though sinu-nasal neoplasms comprise of a small percentage of head neck tumours, they areincreasing in incidence due to rapid industrialization and an increase in life expectancy. Further in many cases they present at an advanced stage and data from studies on them from eastern region of the country is limited, encouraging this study. The aim of this study to evaluate the clinical and demographic profile as well as the histological variation of sinunasal neoplasms and it relation with occupation and addiction. Methods: Design: Prospective study Setting: Tertiary government teaching hospital Participants: All patients presenting with neoplastic lesion in nasal cavity between December, 2009 to May, 2011 Results: Eighty two(82) patients-- 57 (69.51%) male and 25 (30.49%) female aged upto 80 years, were included, displaying male predominance and clustering in the fifth decade of life. Benign lesions (44 cases , 53.66%) were more common than the malignant lesions (33 cases , 40.24% ) and 5 cases (6.10%) were seen indeterminant for malignancy/low-grade malignant potential. Most common anatomical location was nasal cavity(57.32%) and farmers were mostly affected by sinonasal neoplasm (30%). Commonest clinical presentation was epistaxis (31.71%). Conclusion: Sinonasal neoplasms have wide range of possibilities. Commonly, patients present with nasal obstruction and epistaxis. Early diagnosis with the help of newer diagnostic modalities with prompt treatment is necessary for these patients. Histopathological diagnosis is necessary for any neoplastic lesion in nasal cavity. This will guide us for further management of these lesions Keywords: Paranasal sinus ; Neoplastic lesion ; Nasal obstruction ; Epistaxis ; Sinonasal neoplasm
Headache in United States Emergency Departments

Headache is a common complaint in the emergency department (ED). In order to examine headache work-ups and diagnoses across the USA, we queried a representative sample of adult ED visits (the National Hospital Ambulatory Medical Care Survey) for the years 1992–2001. Headache accounted for 2.1 million ED visits per year (2.2% of visits). Of the 14% of patients who underwent neuroimaging, 5.5% received a pathological diagnosis. Of the 2% of patients who underwent lumbar puncture, 11% received a pathological diagnosis. On multivariable analysis, a decreased rate of imaging was noted for patients without private insurance [odds ratio (OR) 0.61, confidence interval (CI) 0.44, 0.86] and for those presenting off-hours (OR 0.55, CI 0.39, 0.77). Patients over 50 were more likely to receive a pathological diagnosis (OR 3.3, CI 1.2, 9.3). In conclusion, clinicians should ensure that appropriate work-ups are performed regardless of presentation time or insurance status, and be vigilant in the evaluation of older patients.
PSR J1723−2837: AN ECLIPSING BINARY RADIO MILLISECOND PULSAR

We present a study of PSR J1723−2837, an eclipsing, 1.86 ms millisecond binary radio pulsar discovered in the Parkes Multibeam survey. Radio timing indicates that the pulsar has a circular orbit with a 15 hr orbital period, a low-mass companion, and a measurable orbital period derivative. The eclipse fraction of ∼15% during the pulsar's orbit is twice the Roche lobe size inferred for the companion. The timing behavior is significantly affected by unmodeled systematics of astrophysical origin, and higher-order orbital period derivatives are needed in the timing solution to account for these variations. We have identified the pulsar's (non-degenerate) companion using archival ultraviolet, optical, and infrared survey data and new optical photometry. Doppler shifts from optical spectroscopy confirm the star's association with the pulsar and indicate a pulsar-to-companion mass ratio of 3.3 ± 0.5, corresponding to a companion mass range of 0.4 to 0.7 M☉ and an orbital inclination angle range of between 30° and 41°, assuming a pulsar mass range of 1.4–2.0 M☉. Spectroscopy indicates a spectral type of G for the companion and an inferred Roche-lobe-filling distance that is consistent with the distance estimated from radio dispersion. The features of PSR J1723−2837 indicate that it is likely a “redback” system. Unlike the five other Galactic redbacks discovered to date, PSR J1723−2837 has not been detected as a γ-ray source with Fermi. This may be due to an intrinsic spin-down luminosity that is much smaller than the measured value if the unmeasured contribution from proper motion is large.
Micronutrient deficiencies in inflammatory bowel disease: From A to zinc

Inflammatory bowel disease (IBD) has classically been associated with malnutrition and weight loss, although this has become less common with advances in treatment and greater proportions of patients attaining clinical remission. However, micronutrient deficiencies are still relatively common, particularly in CD patients with active small bowel disease and/or multiple resections. This is an updated literature review of the prevalence of major micronutrient deficiencies in IBD patients, focusing on those associated with important extraintestinal complications, including anemia (iron, folate, vitamin B12) bone disease (calcium, vitamin D, and possibly vitamin K), hypercoagulability (folate, vitamins B6, and B12), wound healing (zinc, vitamins A and C), and colorectal cancer risk (folate and possibly vitamin D and calcium). (Inflamm Bowel Dis 2012)
Comparative Evaluation of Clinical Efficacy of Two New Gingival Retraction Systems-An In Vivo Research

Background: Making an impression for fixed prosthesis require the gingival tissue to be displaced to expose the finish lines on the prepared teeth. Therefore, effectively managing the gingiva prior to making an impression is a critical preliminary step in the process of fabricating restorations. Because of enormous variability of clinical cases, it is not possible to use a single method or impression material for fixed prosthesis. Aims: The aim of this study was to evaluate and compare the amount of lateral displacement by laser and magicfoam retraction systems. Methods and Material: Study was conducted on prepared right or left maxillary central incisor for 30 subjects. The pre and post displacement impressions were made with addition silicone material using two stage double mix technique. Final cast were sectioned longitudinally into equal halves. The sectioned halves were assessed under stereomicroscope. The measurements were made from crest of gingival margin to midbuccal surface of the tooth. The amount of gingival displacement in each group was calculated by subtracting the pre displacement values from post displacement values. From the observations obtained statistical analysis was performed using independent sample t test. Results: Group A showed more amount of lateral displacement than group B. However, amount of gingival displacement between group A and group B showed statistically significant difference. Conclusion: Laser retraction system produced more lateral displacement of gingival compared to magicfoam retraction system.
Fused deposition modeling of metals

Studies have been conducted to improve previous work performed in developing a Fused Deposition Modeling for metals (FDMm) system used for applications in electronics and fabrication of 3-dimensional metallic structures. A FDM 3000 system was modified to achieve controlled deposition of eutectic Bi58Sn42 and non-eutectic Sn60Bi40 materials. Toolpath command modifications were required to achieve controlled deposition of metals. Results are presented which include a redesigned metal deposition head, computer modeling of fluid flow, and finally examples of the successful deposition of metal alloys. Additionally, FDMmfabricated metal samples were prepared and analyzed using optical and scanning electron microscopy. Controlled deposition of metals using FDMm allows for parts that can be used for jigs and fixtures, electroforming mandrels, encapsulation molds, dies, electronic joining applications, as well as printing 3-dimensional electronic circuitry.