Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationships of Onset and Exacerbation of Pustulosis Palmaris et Plantaris to Smoking and Focal Infections

Clinical data, including focal infection and habitual cigarette smoking, were obtained from 203 male patients with pustulosis palmaris et plantaris (PPP) (age: 43.3 ± 13.4) and 266 female patients (age: 44.0 ± 13.7) for the 20 years from 1975 through 1994 to evaluate the relationship between the onset or severity of PPP and smoking. Seasonal incidences of onset were also studied. The incidence of onset of PPP symptoms was highest in June, when it is the most humid in Japan, and lowest in December. The most common infectious disease associated with PPP was tonsillitis. The percentages of heavy smoking (more than 20 cigarettes per day) were 74.7% and 32.9% for male and female patients, while those in the normal control population in Japan were 37.2% and 9.8% for males and females. These results suggest that heavy smoking, tonsillitis, and seasonal factors such as high humidity and high temperature may be related to the onset and exacerbation of PPP.
DETECTION OF AN OUTBURST ONE YEAR PRIOR TO THE EXPLOSION OF SN 2011ht

Using imaging from the Pan-STARRS1 survey, we identify a precursor outburst at 287 and 170 days prior to the reported explosion of the purported Type IIn supernova (SN) 2011ht. In the Pan-STARRS data, a source coincident with SN 2011ht is detected exclusively in the zP1 and yP1-bands. An absolute magnitude of Mz ≃ −11.8 suggests that this was an outburst of the progenitor star. Unfiltered, archival Catalina Real Time Transient Survey images also reveal a coincident source from at least 258 to 138 days before the main event. We suggest that the outburst is likely to be an intrinsically red eruption, although we cannot conclusively exclude a series of erratic outbursts which were observed only in the redder bands by chance. This is only the fourth detection of an outburst prior to a claimed SN, and lends credence to the possibility that many more interacting transients have pre-explosion outbursts, which have been missed by current surveys.
Native versus non‐native invasions: similarities and differences in the biodiversity impacts of Pinus contorta in introduced and native ranges

To determine whether one of the most invasive pine species introduced to the Southern Hemisphere, Pinus contorta, has changed plant species richness, composition, diversity, and litter depth where it has invaded into native open forest, shrub steppe and grassland communities and to assess whether changes were similar in its native and introduced ranges.
Human papillomavirus and p16 protein expression as prognostic biomarkers in mobile tongue cancer

Abstract Objectives: The objectives were to determine the prevalence of human papillomavirus (HPV) in mobile tongue cancer (MTC) and evaluate associations and survival. Materials and methods: Patients who underwent surgical resection as primary treatment for MTC (n = 127) were retrospectively evaluated. Formalin-fixed paraffin-embedded (FFPE) specimens were assessed for p16 and p53 by immunohistochemistry; for HPV DNA by nested multiplex polymerase chain reaction (PCR) using two pairs of consensus primers (MY09–MY11 and GP5+–GP6+); and for E6 and E7 oncogenes from 13 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 52, 56, 58, 59, 66, and 68) by real-time reverse transcription PCR (RT-PCR). Results: There were 18 (14.2%) p16-positive, 45 (35.4%) p53-positive, 9 (7.1%) HPV DNA-positive, and 7 (5.5%) E6 and/or E7 mRNA-positive tumors, but the correlation of all pairs was poor. There was no demographic or histopathologic association with HPV status. Cause-specific survival was significantly better with p16-positive than with p16-negative tumors (p = .037). Conclusions: The prevalence of HPV and p16 positivity was relatively low and p16 status was a poor surrogate marker for HPV status. The results showed the importance of p16 expression in prognosticating mobile tongue cancer.
Abelard and Héloise: Why Data and Publications Belong Together

This article explores the present state of integration between data and publications. The statistical findings are based on the project PARSE.Insight, which was carried out with the help of EU funding in 2008 - 2010. The main conclusion drawn from these findings is that currently very few conventions and best practices exist among researchers and publishers in how to handle data. There is strong preference among researchers and publishers alike for data and publications to be linked in a persistent way. To achieve that, we advocate good collaboration across the whole information chain of authors, research institutes, data centers, libraries and publishers. DataCite is an excellent example of how this might work.
Safety and immunogenicity of a nonavalent pneumococcal vaccine conjugated to CRM197 administered simultaneously but in a separate syringe with diphtheria, tetanus and pertussis vaccines in Gambian infants

Background. Unrelenting high morbidity and mortality have mandated that immunogenic vaccines be used to combat pneumococcal disease in infants. Objectives. To evaluate the safety and immunogenicity of a nonavalent pneumococcal conjugate vaccine and the antigenic interaction when administered simultaneously with diphtheria, tetanus and pertussis vaccines. Methods. Two hundred seven infants were randomized to receive three doses of either nonavalent protein conjugate pneumococcal vaccine (PnCV) or inactivated polio vaccine (IPV) at 2, 3 and 4 months of age with routine Expanded Program of Immunization vaccines as scheduled. Vaccinees were visited on Days 1, 2 and 7 to observe local and systemic adverse reactions. Blood was drawn before the first dose and 1 month after the third dose. Antibody concentrations in sera were measured by standardized enzyme-linked immunosorbent assay. Nasopharyngeal carriage of pneumococci was tested at 5 and 9 months of age. Results. No serious reactions were observed. Local induration and tenderness were observed more commonly at the site of administration of diphtheria, tetanus and pertussis vaccines than at the site of administration of IPV or PnCV. Between 79 and 91% achieved ≥1 μg/ml antibody against specific pneumococcal serotypes. Antibody responses to diphtheria and pertussis antigens were similar in both groups; however, antibody response to tetanus toxoid was significantly lower in infants who received PnCV (geometric mean concentration, 11.1 vs. 17.4; P < 0.001). Nasopharyngeal carriage in PnCV-vaccinated children was reduced but not significantly different from those vaccinated with IPV. Conclusion. Simultaneous administration of PnCV with Expanded Program of Immunization vaccines is safe and immunogenic. Immune response to the composite antigens is likely to confer protection.
ATTRACTION OF MATED FEMALE CODLING MOTHS (LEPIDOPTERA: TORTRICIDAE) TO APPLES AND APPLE ODOR IN A FLIGHT TUNNEL

Abstract In a flight tunnel, mated female codling moths, Cydia pomonella L. , were attracted (upwind flight with zigzagging flight patterns) to cold-stored thinning apples. Greater numbers of codling moths were attracted to apples infested with codling moth larvae than to uninfested apples. However, codling moth response to piped odor from cold-stored thinning apples infested with larvae was not significantly greater than that of moths to piped odor from uninfested apples. In a flight tunnel, significant numbers of mated female codling moths were captured in traps baited with fresh-picked immature apples or in traps through which odor from such apples was piped. Also, more codling moths were captured in traps baited with infested versus un-infested apples, and more were captured in traps with odor from infested apples compared to odor from un-infested apples. These studies demonstrate upwind attraction by flying female codling moths to apple fruit and odors from apple fruit and show increased response by moths to odors of fruit that are infested with codling moth larvae. It is suggested that this heightened response to infested apples may be due to increased apparency of infested fruit that may release greater amounts of volatile odorants.
Service Profile of Orthognathic Surgery of a Medical School

Abstract Orthognathic surgeries are very important for both the correction of dentofacial deformities as well as for the treatment of obstructive sleep apnea/hypopnea syndrome. Nowadays, most of the population presents some type of morphological and/or functional disorder of the stomatognathic system. Aim The present study aims at assessing the information from the individuals treated in the Orthognathic Surgical Service of a Medical School. Methods Search in medical records - 2004-2008, identification procedures, individual characteristics, malocclusion and surgery. Results The number of surgical treatments due to dentofacial deformities has been increasing. Maxillary advancement surgery alone comprised the highest number in the sample. Conclusion Orthognathic surgery cases have been increasing in the last years and maxillary advancement alone comprised the highest number of surgical treatments.
The recognition of emotional expression in prosopagnosia: Decoding whole and part faces

Prosopagnosia is currently viewed within the constraints of two competing theories of face recognition, one highlighting the analysis of features, the other focusing on configural processing of the whole face. This study investigated the role of feature analysis versus whole face configural processing in the recognition of facial expression. A prosopagnosic patient, SC made expression decisions from whole and incomplete (eyes-only and mouth-only) faces where features had been obscured. SC was impaired at recognizing some (e.g., anger, sadness, and fear), but not all (e.g., happiness) emotional expressions from the whole face. Analyses of his performance on incomplete faces indicated that his recognition of some expressions actually improved relative to his performance on the whole face condition. We argue that in SC interference from damaged configural processes seem to override an intact ability to utilize part-based or local feature cues. (JINS, 2006, 12, 884–895.)
Intracoronary secretin increases cardiac perfusion and function in anaesthetized pigs through pathways involving β‐adrenoceptors and nitric oxide

• What is the central question of this study? What is the primary effect of secretin on cardiac function and perfusion? Are the autonomic nervous system, secretin receptors and NO involved? • What is the main finding and its importance? Intracoronary secretin increases cardiac perfusion and function through β‐adrenoceptors and secretin receptors in the anaesthetized pig, with the coronary vasodilatation involving NO release. As downstream effectors of the observed NO production, cAMP/protein kinase A and phosphoinositide 3‐kinase/Akt‐related signalling were found. Thus, secretin could play an important role in the modulation of cardiovascular reflexes elicited by stimulation of gastrointestinal mechano/chemoreceptors. Moreover, secretin could hypothetically have a potential use in the treatment of acute left ventricular failure or ischaemic heart disease.
The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT‐mediated inflammatory bone destruction

Formation of osteoclasts and consequent joint destruction are hallmarks of rheumatoid arthritis (RA). Here we show that LIGHT, a member of the tumour necrosis factor (TNF) superfamily, induced the differentiation into tartrate‐resistant acid phosphatase (TRAP)‐positive multinucleated cells (MNCs) of CD14+ monocytes cocultured with nurse‐like cells isolated from RA synovium, but not of freshly isolated CD14+ monocytes. Receptor activator of nuclear factor‐κB ligand (RANKL) enhanced this LIGHT‐induced generation of TRAP‐positive MNCs. The MNCs showed the phenotypical and functional characteristics of osteoclasts; they showed the expression of osteoclast markers such as cathepsin K, actin‐ring formation, and the ability to resorb bone. Moreover, the MNCs expressed both matrix metalloproteinase 9 (MMP‐9) and MMP‐12, but the latter was not expressed in osteoclasts induced from CD14+ monocytes by RANKL. Immunohistochemical analysis showed that the MMP‐12‐producing MNCs were present in the erosive areas of joints in RA, but not in the affected joints of osteoarthritic patients. These findings suggested that LIGHT might be involved in the progression of inflammatory bone destruction in RA, and that osteoclast progenitors might become competent for LIGHT‐mediated osteoclastogenesis via interactions with synoviocyte‐like nurse‐like cells.
Prospective Identification of Autism Spectrum Disorders in Infancy and Toddlerhood Using Developmental Surveillance: The Social Attention and Communication Study

Objective: Despite behavioral markers of autism spectrum disorders (ASDs) being evident within the first year of life, there remains little research on the prospective identification of these children in a community-based setting before 18 months. The aim in the Social Attention and Communication Study was to identify infants and toddlers at risk of an ASD during their first 2 years. Methods: A total of 241 Maternal and Child Health nurses were trained on the early signs of ASDs at 8, 12, 18 and 24 months. Using a developmental surveillance approach with a community-based sample, a cohort of 20,770 children was monitored on early social attention and communication behaviors. Those infants/toddlers identified as “at risk” were referred to the Social Attention and Communication Study team from 12 months for developmental and diagnostic assessments at 6 monthly intervals, until 24 months. Results: A total of 216 children were referred, with 110 being further assessed. Of these, 89 children were classified with an ASD at 24 months, and 20 children had developmental and/or language delays, resulting in a Positive Predictive value of 81%. The estimated rate of ASDs in the Social Attention and Communication Study cohort ranged from 1:119 to 1:233 children. Estimated sensitivity ranged from 69% to 83.8%, and estimated specificity ranged from 99.8% to 99.9%. Conclusion: Developmental surveillance of social and communication behaviors, which differ according to the age at which the child is monitored, enables the accurate identification of children at risk for ASDs between 12 and 24 months. Education on the early signs is recommended for all primary health care professionals to facilitate early identification of ASDs.
Diet composition and surgical technique influence the postoperative recovery of portacaval shunted rats

In a series of experiments, rats were subjected to end‐to‐side portacaval shunts using either suture or nonsuture surgical procedures. Rats were maintained on cereal‐based or purified diets in pellet form. All rats recovered preoperative body weights within the experimental periods; however, recovery of preoperative body weight was influenced by surgical technique and diet composition. Portacaval shunted rats fed a cereal‐based diet required a longer period of time (14 days) to reattain preoperative body weights when compared to portacaval shunted rats fed a purified diet (7 days). Once preoperative body weight was recovered, growth rates of portacaval shunted rats were parallel to those of sham‐operated controls. Rats with a suture‐portacaval shunt appeared most sensitive to the feeding of a cereal‐based diet. All portacaval shunted rats and sham controls fed a purified diet regained preoperative body weights within 7 days after surgery. Sham controls fed either a cereal‐based or purified diet recovered preoperative body weights within an average of 4 days. Suture‐portacaval shunted rats consuming a pellet form cereal‐based diet showed a low feed efficiency which could be reversed by feeding a pellet form purified diet.
Cytomegalovirus colitis complicating ulcerative colitis in the steroid-naive patient

We report a case of cytomegalovirus (CMV) presenting as acute refractory colitis in a patient with a pre-existing 14-month history of ulcerative colitis (UC) who had never previously been treated with corticosteroids or immunosuppressants. A review of existing literature and previous cases of patients with coincident CMV and UC are examined, stratifying these cases based upon absence or presence of corticosteroid use. To date, only five previous case reports of CMV colitis in patients naive to corticosteroids have been described, and only one previous case has had UC diagnosed over 4 wk before the development of CMV colitis. We further discuss the relationship between these two diseases as well as the diagnosis, treatment, patient characteristics, and outcome of CMV infection of the colon in patients with underlying UC. We discuss the need to consider the diagnosis of CMV colitis in patients with refractory UC who are not receiving corticosteroid treatment as well as those who are refractory and are being treated with immunosuppressants and/or corticosteroids.
A Review of American Psychiatry Through Its Diagnoses: The History and Development of the Diagnostic and Statistical Manual of Mental Disorders

Abstract The history of the Diagnostic and Statistical Manual of Mental Disorders (DSM) reflects the larger history of American psychiatry. As the field anticipates DSM-5, it is useful to take stock of this history and consider not only how diagnosis impacts our understanding of mental illness but also how contemporary thought influences diagnosis. Before the DSM, the field was disjointed. The publication of the first American diagnostic manual, the precursor of the DSM, mirrored society’s interest in organized record keeping and prevention rather than treatment of mental illness. The first and second editions of DSM brought a common language to diagnosis and were largely the work of outpatient and academic psychiatrists rather than those based in large state hospitals. The third edition of the DSM saw the shift in American psychiatry’s leadership from the eminent clinician to the researcher, whereas the fourth edition reflected the rise of “evidence-based medicine. ” DSM-5 will likewise represent the current status of the field—not only with regard to science but also reflecting the place of American psychiatry in medicine today.
Left and right ventricular systolic long‐axis function and diastolic function in patients with takotsubo cardiomyopathy

Aims: Takotsubo cardiomyopathy is characterized by apical wall motion abnormalities without coronary stenosis. Limited information is available on the genesis of the underlying reversible contractile disorder. Our objective in this prospective study was to investigate biventricular changes in systolic long‐axis function and diastolic parameters in the acute phase and after recovery.
Fixation with formaldehyde induces expression of activation dependent platelet membrane glycoproteins, P selectin (CD62) and GP53 (CD63)

Summary. Platelet activation in vivo is important in the pathogenesis of thrombosis. Accurate measurement is difficult due to artefactual in vitro preparation related activation. This can be overcome by using whole blood techniques, such as flow cytometry. However, there is little consensus on methods of platelet preparation, procedures for use of fixation, or the optimal types/amounts of fixative. The use of unfixed platelets has received little attention.
A Novel Tenebrio molitor Cadherin Is a Functional Receptor for Bacillus thuringiensis Cry3Aa Toxin*

Cry toxins produced by the bacterium Bacillus thuringiensis are effective biological insecticides. Cadherin-like proteins have been reported as functional Cry1A toxin receptors in Lepidoptera. Here we present data that demonstrate that a coleopteran cadherin is a functional Cry3Aa toxin receptor. The Cry3Aa receptor cadherin was cloned from Tenebrio molitor larval midgut mRNA, and the predicted protein, TmCad1, has domain structure and a putative toxin binding region similar to those in lepidopteran cadherin B. thuringiensis receptors. A peptide containing the putative toxin binding region from TmCad1 bound specifically to Cry3Aa and promoted the formation of Cry3Aa toxin oligomers, proposed to be mediators of toxicity in lepidopterans. Injection of TmCad1-specific double-stranded RNA into T. molitor larvae resulted in knockdown of the TmCad1 transcript and conferred resistance to Cry3Aa toxicity. These data demonstrate the functional role of TmCad1 as a Cry3Aa receptor in T. molitor and reveal similarities between the mode of action of Cry toxins in Lepidoptera and Coleoptera.
Become Classroom Music Teachers or Music Performers Motivational Constructs Influencing Undergraduate Students ' Choices to

The primary purpose of this study was to examine whether any of the six motivational constructs in the expectancy-value model of motivation (i.e., expectancy, ability perceptions, intrinsic interest value, attainment value, social utility value, and cost) would predict whether students intended to have a career teaching classroom music or performing music. Participants included 270 undergraduate students enrolled in music programs at seven major U.S. universities who completed an online questionnaire. Using stepwise multiple regression, the authors documented that attainment value, intrinsic interest value, and expectancy predicted 74% of the variance in whether students intended to choose a career teaching music. They found that expectancy, attainment value, ability perceptions, and intrinsic interest value explained 65% of the variance in whether students intended to choose a career in music performance. Because of the importance of attainment value in predicting students’ intentions to teach and the importance of expectancies in predicting their intentions to have a performance career, these two constructs would be obvious choices for teachers and advisors to target if they want to encourage students to pursue these careers.
Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation

Menstrual endometrial breakdown induced by estradiol and progesterone withdrawal is regularly attributed to vasospasm of spiral arteries causing ischemia and hypoxia. We investigated whether hypoxia actually occurred in an in vivo model of menstruation. Three complementary approaches were used to look for signs of hypoxia in fragments of human functionalis xenografted to ovariectomized immunodeficient mice bearing pellets‐releasing estradiol and progesterone, and then deprived of ovarian steroids. Hormone withdrawal 21 d after grafting induced menstrual breakdown and MMP expression within 4 d. Local partial oxygen pressure (pO2) was measured by electron paramagnetic resonance using implanted lithium phtalocyanine crystals. In mice with hormone maintenance until sacrifice, pO2 was low one week after grafting (14.8±3.4 mmHg) but increased twofold from the second week when tissue was largely revascularized. After 3 wk, pO2 was not modified by hormone withdrawal but was slightly increased on hormone reimpregnation 4 d after removal (34.7 ±6.1 mmHg) by comparison with hormone maintenance (27.1 ±8.6 mmHg). These results were confirmed using fluorescence quenching‐based OxyLite measurements. In a further search for signs of hypoxia, we did not find significant HIF1‐α immunostaining, nor pimonidazole adducts after hormone withdrawal. We conclude that hypoxia is not needed to trigger menstrual‐like tissue breakdown or repair in human endometrial xenograft. —Coudyzer, P., Lemoine, P., Jordan, B. F. , Gallez, B. , Galant, C. , Nisolle, M. , Courtoy, P. J., Henriet, P., and Marbaix, E. , Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation. FASEB J. 27, 3711–3719 (2013). www.fasebj. org