Miracle-dz/UniFAR-FTUs huggingface dataset:
Dual Active Bridge-Based Battery Charger for Plug-in Hybrid Electric Vehicle With Charging Current Containing Low Frequency Ripple

Manufacturers want high power density for the on-board battery chargers of plug-in hybrid electric vehicles. Wide bandgap devices can be used to shrink other passive components by increasing the switching frequency, but the bulk dc link capacitor of the ac-dc power factor correction stage, becomes one of the major barriers to higher power density, because its volume depends on the ripple power at the double line frequency in a dc current charging system. However, if this double line frequency ripple flows into the battery, the dc link capacitance can be significantly reduced. This charging scheme, named as sinusoidal charging in this paper, is analyzed and implemented based on a two-stage battery charging system, which is comprised of one full bridge ac-dc stage and one dual active bridge dc-dc stage. We further find that converter loss causes ripple power imbalance and bigger dc link capacitance. Therefore, the impact of converter loss on the ripple power balance is analyzed, and a feedback control on the dc link voltage ripple is proposed based on this analysis in order to further reduce the dc link capacitance. The effectiveness of the proposed solutions is verified in both Si-based and GaN-based charging systems.
Reconstruction of Escherichia coli mrcA (PBP 1a) Mutants Lacking Multiple Combinations of Penicillin Binding Proteins

ABSTRACT Previously, we constructed a set of mutants from which eight penicillin binding protein (PBP) genes were deleted in 192 combinations from Escherichia coli (S. A. Denome, P. K. Elf, T. A. Henderson, D. E. Nelson, and K. D. Young, J. Bacteriol. 181:3981-3993, 1999). Although these mutants were constructed correctly as determined by restriction mapping and the absence of relevant protein products, we recently discovered by PCR mapping that strains from which mrcA (PBP 1a) was deleted were also missing two neighboring genes of unknown function (yrfE and yrfF). We created a new deletion mutation in mrcA and reconstructed 63 strains lacking PBP 1a and other PBP mutant combinations. The new mrcA mutants do not exhibit mucoidy, phage resistance, temperature sensitivity, growth rate defects, or antibiotic resistance, suggesting that these phenotypes require the loss of either yrfE oryrfF alone or in combination with the absence of multiple PBPs.
Sex differences in the use of the Internet as a source of health information among adolescents.

BACKGROUND The Internet is a fundamental part of the day-to-day lives of adolescents. Faced with the difficulties of accessing conventional health services, adolescents use the Internet as a confidential and safe means of accessing information about health issues. OBJECTIVES To describe sex differences in the way in which adolescents search for health information on the Internet. METHODS Cross-sectional survey with a questionnaire administered by an interviewer. Sociodemographic and health variables and those related to the conditions of access and use of information and communication technologies were gathered (multivariate analysis). RESULTS About 823 school-age youths were interviewed (21 questionnaires were discarded due to low quality), among whom 54.1% were girls and 46% were boys. The girls had a lower self-assessed level of health than the boys. About 86.5% of the girls used the Internet, compared with 89.9% of the boys (p = 0.155). About 21.7% and 48.3% of the boys used it daily/weekly and occasionally, respectively, compared with 17.9% and 59.1% of the girls who used it daily/weekly and occasionally, respectively. The multivariate analysis shows that girls (odds ratio [OR], 1.709; 95% confidence interval [CI], 1.277-2.287), those in their last year of secondary school (OR, 1.369; 95% CI, 1.025-1.830) and those who had visited the doctor most often the previous year (OR, 1.061; 95% CI, 1.017-1.107), were statistically significantly more likely to search for health information on the Internet. CONCLUSION Adolescent girls tend to seek more information about health than boys and there are differences in the way in which these girls search for health information on the Internet. The Internet provides adolescents, especially adolescent girls, with an opportunity for relaying health recommendations.
Chronic psychosocial stress exacerbates impairment of synaptic plasticity in β-amyloid rat model of Alzheimer's disease: prevention by nicotine.

Alzheimer's disease (AD) is a degenerative disorder that leads to progressive, irreversible cognitive decline. It develops as a result of over-production and aggregation of β-amyloid (Aβ) peptides in the brain. We have recently shown that stress exacerbates, while nicotine prevents long-term memory impairment induced by β-Amyloid. In this study, we evaluated the effect of chronic psychosocial stress on synaptic plasticity (Late-phase long-term potentiation; L-LTP, and long-term depression; LTD) in the β-Amyloid rat model of AD, and the positive impact of chronic nicotine treatment. Chronic psychosocial stress was induced by an intruder method. The Rat AD model was induced by 14-day i.c. v. osmotic pump infusion of a 1:1 mixture of 300 pmol/day Aβ1-40/Aβ1-42. The rats were treated with nicotine (2 mg/kg/day) for 6 weeks. In vivo electrophysiological recordings of L-LTP, and LTD in hippocampal area CA1 showed that chronic stress by itself did not affect L-LTP. However, it markedly aggravated the impairment of this response as well as LTD in Aβ- treated rats. The effects of Aβ and the combination of stress and Aβ were totally prevented by chronic nicotine treatment. Immunoblot analysis revealed that stress and/or Aβ significantly increased the basal levels of calcineurin and prevented the expected L-LTP-induced increase in CREB phosphorylation, and CaMKIV levels. These effects were not seen in Aβ- infused rats chronically treated with nicotine. The changes in synaptic plasticity-related molecules may explain the effects of stress and/or chronic nicotine on L-LTP in Aβ animals.
Anticancer activity of Sasa borealis leaf extract-mediated gold nanoparticles

Abstract Advancements in metal nanoparticle synthesis using plant extracts and their anticancer activity have received significant attention in recent years. The green approach for the synthesis of gold nanoparticles (AuNPs) using leaf extract of Sasa borealis is reported in this study. Synthesis of AuNPs was performed at 50 °C, and nanoparticle formation was observed after 20 min incubation. AuNPs formation was confirmed by the UV–visible spectrum peak at 542 nm. The synthesized AuNPs were oval, spherical with sizes around 10–30 nm observed using the transmission electron microscope. Energy dispersive X-ray analysis was utilized for the detection of elemental compound. The face centered cubic structure was confirmed by X-ray diffraction pattern. The reduction of tetrachloroauric acid into AuNPs by the phytochemical compounds of S. borealis extract was determined by Fourier transform infrared spectroscopy and the presence of biomolecules was studied by GC–MS. The synthesized AuNPs was tested for toxic effect on HEK293 cells and anticancer activity on AGS cells by WST-1® assay. Condensation or fragmentation is a characteristics of apoptosis, which was confirmed by 4,6-diamidino-2-pheynylindole dihydrochoride (DAPI) staining. The S. borealis-mediated AuNPs have good activity as an anticancer agent and it will be beneficial in cancer therapeutics.
Synthesis of hapten and production of a monoclonal antibody against a derivative of L-hydroxyproline, a special amino acid in hydrolyzed animal protein

China's government has prohibited the addition of simply hydrolyzed animal protein from solid leather waste into milk. The objective of this study was to produce a monoclonal antibody against L-hydroxyproline, a special amino acid in hydrolyzed animal protein. L-hydroxyproline was derivatized with N-acetylsulfanilyl chloride and 5-chlorovaleric acid to synthesize the haptens HP1 and HP2. Then, two immunogens from the two haptens were prepared to produce the antibodies. Results showed that only HP1 was able to stimulate the animal immune system and generate the specific antibody to L-hydroxyproline (as the formation of HP1). The obtained monoclonal antibody from HP1 and the heterologous coating hapten HP2 were incorporated into a competitive indirect enzyme linked immunosorbent assay (ELISA) to determine the antibody's specificity and sensitivity. The IC50 and the limit of detection for HP1 were 0.16 μg/mL and 0.05 μg/mL respectively. The antibody showed low crossreactivity to parental L-hydroxyproline and showed negligible crossreactivity to D-hydroxyproline and other amino acids. The monoclonal antibody was therefore suitable for the development of an immunoassay to monitor the simply hydrolyzed animal protein from solid leather waste in foodstuffs with L-hydroxyproline as the target analyte.
Building Economic Efficiency into Multicast Content Delivery Networks

Internet-scale dissemination of streaming contents (e.g. live sport games) is most successfully being provided by Multicast Content Delivery Networks (Multicast CDN). Multicast CDN is composed of dedicated servers placed strategically over the Internet, which forward content from origin site to end users. Multicast CDN delivers huge amount of data traffic, and therefore its major operational cost is the ISP cost for network access. Existing Multicast CDNs route user requests to most suitable server based on application performance, such as network delay, server throughput, Internet path congestion etc., without taking into account the potentially high ISP cost it may incur. Multicast CDNs need to control their ISP cost to remain commercially competitive since ISP cost is the most indicative factor affecting the pricing of their services. In this work, we present novel Multicast CDN Request Routing algorithms that minimize ISP cost while still maintaining good network performance for users. Multicast CDN Request Routing algorithms control majority of traffic assigned to servers and therefore directly impacts the ISP cost. ISP cost and user network performances are orthogonal metrics of performance and in order to balance the trade-off between them we introduce overall delay as a constraint to the Multicast CDN Request Routing algorithm. Multicast CDNs are business customers of ISPs and therefore can independently choose to reduce their bills by considering the ways in which ISPs charge. We have designed Request Routing algorithms that exploit the economy of scale in ISP charging function in assigning users to servers. We have developed Request Routing algorithms that exploit the nature of Percentile-based charging used by ISPs to compute the charging volume for traffic generated at server sites. Multicast CDN can cooperate with ISPs to reduce the operational cost of both the parties. Multicast CDN controls how traffic is redirected on the overlay, and that can conflict with how underlying ISPs want the traffic to be forwarded. We have developed Request Routing algorithms that assign users to servers that are available over cheaper IP routes. This reduces the transmission costs for ISPs and these savings can be transferred onto Multicast CDN.
Absolute low-energy e--Ar scattering cross sections.

Relative measurements of {ital e}{sup {minus}}-Ar angular distributions in the energy range 3--20 eV have been placed on an absolute scale by both a phase-shift analysis and relative flow normalization. The two sets of absolute differential cross sections are in excellent agreement with each other over the entire energy range. These measurements are also in agreement with previous calculations and measurements in different energy and angular ranges. Total cross sections calculated from the derived phase shifts are in excellent agreement with recent direct experimental determinations.
An Investigation of the Relationship Between Cortical Connectivity and Schizotypy in the General Population

Recent neuroimaging investigations have identified a relationship between psychotic symptoms in schizophrenia and abnormal brain connectivity. On the basis of the continuum model of psychosis, it was hypothesized that schizotypal traits in healthy control participants would be associated with relatively impaired frontotemporal white matter health as assessed using diffusion tensor imaging. Twenty-one participants (12 women and 9 men aged 18 to 58 years) completed the Schizotypal Personality Questionnaire (SPQ) and underwent diffusion-weighted magnetic resonance imaging scanning as part of a larger study. White matter integrity for the major association fibre tracts was assessed using standard measures of diffusivity, specifically fractional anisotropy (FA) and axial and radial diffusivity. A series of negative binomial regressions yielded significant relationships between reduced FA in seven white matter tracts and increased scores on the SPQ cognitive-perceptual factor. These findings are consistent with research relating brain connectivity to the positive symptoms of schizophrenia, suggesting that the neurobiological bases of schizotypal personality in healthy controls may be analogous to the neurobiological bases of schizophrenia spectrum disorders.
Cardiovascular management of Marfan syndrome.

• Vol 10 • March 2008 182 In 1896, at a meeting of the Medical Society of Paris hospitals, Antoine Marfan presented a 5 year old girl with abnormalities of the skeletal system and elongation of the long bones and fingers (arachnodactyly). In 1914 the disorder was given official recognition as Marfan syndrome, based on skeletal abnormalities and ectopia of the lenses. In 1943, a description of a dilated aortic root as well as dissection was reported for the first time [1]. Marfan syndrome is an autosomal dominant connective tissue disorder affecting mainly the cardiovascular system, eyes and skeleton. With regard to its epidemiology, the incidence is approximately 1:5000–10,000; about 25% of cases have no family history and their syndrome is the result of sporadic mutation [2-4]. Marfan syndrome affects males and females equally and appears to be distributed equally among all races and ethnic groups.
Physical activity ratio of selected activities in Indian male and female subjects and its relationship with body mass index

The physical activity level of an individual can be determined by assigning physical activity ratios (PAR) to different activities. The PAR is the ratio of the energy expended in a particular activity and the BMR, and is thought to be independent of body weight. PAR values of selected activities in Indian male and female subjects were measured and their association with BMI was assessed. The BMR and energy cost of selected activities were measured in thirty male and thirty female subjects in the age group of 20–40 years, who were categorised into different groups of BMI. The PAR values of the underweight male subjects were significantly lower than the overweight subjects for activities such as walking at 3·2 and 4·8km/h and walking at 3·2km/h with a 5kg load. In the female subjects, the underweight subjects had significantly lower PAR values for floor swabbing, and walking at 3·2 and 4·8km/h when compared with overweight females. The mean data of the male and female subjects of the present study were slightly but significantly different to the previously reported FAO, WHO and United Nations University values and other compilations. The BMI was significantly correlated with the PAR value of the studied activities. In India, where a large proportion of the population have BMI below 18·5 and above 25kg/m2, considerations of the influence of body weight and BMI on PAR become important in accurately determining total energy expenditure.
A Control Method for Voltage Balancing in Modular Multilevel Converters

The modular multilevel converter (MMC) is attractive for medium- or high-power applications because of the advantages of its high modularity, availability, and high power quality. The voltage balancing of the floating capacitors in the cascaded submodules of the MMC is a key issue. In this paper, a voltage-balancing control method is proposed. This method uses the phase-shifted carrier-based pulsewidth modulation scheme to control high-frequency current components for capacitor voltage balancing in the MMC without measuring the arm currents. Simulations and experimental studies of the MMC were conducted, and the results confirm the effectiveness of the proposed capacitor voltage-balancing control method.
Energy band alignment in chalcogenide thin film solar cells from photoelectron spectroscopy

Energy band alignment plays an important role in thin film solar cells. This article presents an overview of the energy band alignment in chalcogenide thin film solar cells with a particular focus on the commercially available material systems CdTe and Cu(In,Ga)Se2. Experimental results from two decades of photoelectron spectroscopy experiments are compared with density functional theory calculations taken from literature. It is found that the experimentally determined energy band alignment is in good agreement with theoretical predictions for many interfaces. These alignments, in particular the theoretically predicted alignments, can therefore be considered as the intrinsic or natural alignments for a given material combination. The good agreement between experiment and theory enables a detailed discussion of the interfacial composition of Cu(In,Ga)Se2/CdS interfaces in terms of the contribution of ordered vacancy compounds to the alignment of the energy bands. It is furthermore shown that the most important interfaces in chalcogenide thin film solar cells, those between Cu(In,Ga)Se2 and CdS and between CdS and CdTe are quite insensitive to the processing of the layers. There are plenty of examples where a significant deviation between experimentally-determined band alignment and theoretical predictions are evident. In such cases a variation of band alignment of sometimes more than 1 eV depending on interface preparation can be obtained. This variation can lead to a significant deterioration of device properties. It is suggested that these modifications are related to the presence of high defect concentrations in the materials forming the contact. The particular defect chemistry of chalcogenide semiconductors, which is related to the ionicity of the chemical bond in these materials and which can be beneficial for material and device properties, can therefore cause significant device limitations, as e.g. in the case of the CuInS2 thin film solar cells or for new chalcogenide absorber materials.
Prevalence of Diabetes Mellitus in the Surgical Population of the University of Puerto Rico Affiliated Hospitals: A Study using the Surgery Database.

OBJECTIVE To evaluate the prevalence of diabetes mellitus in the surgical population of the University of Puerto Rico (UPR)-affiliated hospitals. METHODS We examined all the surgical cases that were entered into the Surgical Database from April 1, 2014 through September 30, 2014. This database collects patient and procedural information from different surgical services of various UPR-affiliated hospitals (the University District Hospital, the University Pediatric Hospital, the UPR Carolina Hospital, the Dr. Isaac Gonzalez Oncologic Hospital, the PR Cardiovascular Center [thoracic service], the Pavia Hospital [colorectal service], and the Auxilio Mutuo Hospital [colorectal and oncological services]). The prevalence of diabetes mellitus (types 1 and 2 combined) was estimated, and the nondiabetic and diabetic groups were compared. The difference between groups was evaluated using a Chi2 test, Student's t-test, or ANOVA, whichever was appropriate, with a p-value of less than 0.05 being considered significant. RESULTS Information from 2,603 surgical patients was available. The mean age of the group was 49 (±23) years. The gender distribution indicated that 56% were women and 44% were men. Diabetes was present in 21% of the surgical population, increasing to 40% in patients aged 65 and over. The surgical procedures most frequently required by diabetic patients were in the categories of general surgery (36%), colorectal surgery (22%), vascular surgery (16%) and oncologic surgery (14%). Complications (5%, diabetic group vs. 2%, nondiabetic group; p < 0.05) and postoperative mortality (2%, diabetic group vs. 0.2%, nondiabetic group; p < 0.05) were significantly higher in the diabetic group than in the nondiabetic group. CONCLUSION Our surgical population has a high prevalence of diabetes, and these diabetic patients showed higher complication and mortality rates from surgery than did the non-diabetic patients. Surgeons must consider the specific needs of these diabetic patients in order to provide optimal care.
of spatially relevant and irrelevant optic flow: An investigation with fMRI

■ Perception of known patterns results from the interaction of current sensory input with existing internal representations. It is unclear how perceptual and mnemonic processes interact when visual input is dynamic and structured such that it does not allow immediate recognition of obvious objects and forms. In an fMRI experiment, meaningful visual motion stimuli depicting movement through a virtual tunnel and indistinct, meaningless visual motion stimuli, achieved through phase scrambling of the same stimuli, were presented while participants performed an optic flow task. We found that our indistinct visual motion stimuli evoked hippocampal activation, whereas the corresponding meaningful stimuli did not. Using independent component analysis, we were able to demonstrate a functional connectivity between the hippocampus and early visual areas, with increased activity for indistinct stimuli. In a second experiment, we used the same stimuli to test whether our results depended on the participantsʼ task. We found task-independent bilateral hippocampal activation in response to indistinct motion stimuli. For both experiments, psychophysiological interaction analysis revealed a coupling from posterior hippocampus to dorsal visuospatial and ventral visual object processing areas when viewing indistinct stimuli. These results indicate a close functional link between stimulus-dependent perceptual and mnemonic processes. The observed pattern of hippocampal functional connectivity, in the absence of an explicit memory task, suggests that cortical–hippocampal networks are recruited when visual stimuli are temporally uncertain and do not immediately reveal a clear meaning. ■
Chronic Lateral Instability: Arthroscopic Findings and Long-Term Results

Background: A wide variety of procedures have been described to treat chronic lateral ankle instability. Nonanatomic procedures sacrifice normal tissue and can restrict motion. Anatomic reconstruction of the anterior talofibular and calcaneofibular ligaments, supplemented by reefing of the exstensor retinaculum (modified Broström procedure) provides good long-term stability with minimal drawbacks. Methods: Twenty-one patients had arthroscopic evaluation followed by the Gould modification of the Broström procedure. All patients filled out a detailed questionnaire, including the American Orthopaedic Foot and Ankle Society Ankle/Hindfoot Score, Modified Weber Score, and Hamilton Score at an average of 60 months after surgery. All patients were re-examined, and 14 had stress radiographs for comparison with the preoperative films. Results: Ninety-five percent of the patients (20 of 21) had associated intra-articular problems. The mean score for the Modified Weber Score was 96; for the Ankle/Hindfoot Score, 97; and for the Hamilton score, 100% good and excellent results. All 14 patients recorded a side-to-side difference of less than 3 degrees on their postoperative stress radiographs. Conclusions: A high percentage of patients with lateral ankle instability have intra-articular pathology. Excellent results can be expected in patients with ankle instability who undergo arthroscopic treatment of associated intra-articular pathology and the modified Broström procedure.