Miracle-dz/UniFAR-FTUs huggingface dataset:
Convergent and divergent validity of the Connor-Davidson Resilience Scale in children with concussion and orthopaedic injury

ABSTRACT Objective. Psychological resilience is an important predictor of outcome in concussion; however, there is no published evidence of psychometric support for use of a measure of psychological resilience in children with concussion. This study examined construct validity of the Connor-Davidson Resilience Scale (CD-RISC) in a paediatric concussion and orthopaedic injury sample. Methods. Seventy-five children with a history of concussion or orthopaedic injury were recruited from a children’s hospital. Total sample and within-group correlations between the CD-RISC (25- and 10-item versions) and measures presumed to be related or unrelated to the construct of psychological resilience were analysed. Results. In the total sample, both versions of the CD-RISC were negatively correlated with self-reported depressive symptoms and general behaviour problems. The 10-item version was also negatively correlated with parent-reported general behaviour problems and self-reported anxiety, and was positively correlated with self-reported quality of life. The injury groups did not exhibit significantly different correlations. Conclusions. The construct validity of the CD-RISC is satisfactory when used with children with concussion. The 10-item version may provide a more efficient measure of resiliency with better construct validity in this population.
Mesenchymal stem cells derived from human iPS cells via mesoderm and neuroepithelium have different features and therapeutic potentials

Mesenchymal stem cells (MSCs) isolated from adult human tissues are capable of proliferating in vitro and maintaining their multipotency, making them attractive cell sources for regenerative medicine. However, the availability and capability of self-renewal under current preparation regimes are limited. Induced pluripotent stem cells (iPSCs) now offer an alternative, similar cell source to MSCs. Herein, we established new methods for differentiating hiPSCs into MSCs via mesoderm-like and neuroepithelium-like cells. Both derived MSC populations exhibited self-renewal and multipotency, as well as therapeutic potential in mouse models of skin wounds, pressure ulcers, and osteoarthritis. Interestingly, the therapeutic effects differ between the two types of MSCs in the disease models, suggesting that the therapeutic effect depends on the cell origin. Our results provide valuable basic insights for the clinical application of such cells.
Mining the effector repertoire of the biotrophic fungal pathogen Ustilago hordei during host and non-host infection.

The success of plant-pathogenic fungi mostly relies on their arsenal of virulence factors which are expressed and delivered into the host tissue during colonization. The biotrophic fungal pathogen Ustilago hordei causes covered smut disease on both barley and oat. In this study, we combined cytological, genomics and molecular biological methods to achieve a better understanding of the molecular interactions in the U. hordei-barley pathosystem. Microscopic analysis revealed that U. hordei densely colonizes barley leaves on penetration, in particular the vascular system. Transcriptome analysis of U. hordei at different stages of host infection revealed differential expression of the transcript levels of 273 effector gene candidates. Furthermore, U. hordei transcriptionally activates core effector genes which may suppress even non-host early defence responses. Based on expression profiles and novelty of sequences, knockout studies of 14 effector candidates were performed in U. hordei, which resulted in the identification of four virulence factors required for host colonization. Yeast two-hybrid screening identified potential barley targets for two of the effectors. Overall, this study provides a first systematic analysis of the effector repertoire of U. hordei and identifies four effectors (Uvi1-Uvi4) as virulence factors for the infection of barley.
Treating and reducing anxiety and pain in the paediatric emergency department-TIME FOR ACTION-the TRAPPED quality improvement collaborative.

Background/Objectives In 2013, the TRAPPED-1 survey reported inconsistent availability of pain and distress management strategies across all 15 Canadian paediatric emergency department (PEDs). The objective of the TRAPPED-2 study was to utilize a procedural pain quality improvement collaborative (QIC) and evaluate the number of newly introduced pain and distress-reducing strategies in Canadian PEDs over a 2-year period. Methods A QIC was created to increase implementation of new strategies, through collaborative information sharing among PEDs. In 2015, 11 of the 15 Canadian PEDs participated in the TRAPPED QIC. At the end of the year, the TRAPPED-2 survey was electronically sent to a representative member at each of the 15 PEDs. The successful introduction of the chosen strategies by the QIC was assessed as well as the addition of new strategies per site. The number of new strategies introduced in the participating and nonparticipating QIC sites were described. Results All 15 PEDs (100%) completed the TRAPPED-2 survey. Overall, 10/11 of QIC-participating sites implemented the strategy they had initially identified. All 15 Canadian PEDs implemented some new strategies during the study period; participants in the QIC reported a mean of 5.2 (1-11) new strategies compared to 2.5 (1-4) in the nonactively participating sites. Conclusion While all PEDs introduced new strategies during the study, QIC-participating sites successfully introduced the majority of their previously identified new strategies in a short time period. Sharing deadlines and information between centres may have contributed to this success.
Cardiovascular disease in Williams syndrome

Purpose of review Williams syndrome is a multisystem disorder seen with some regularity at most pediatric centers and usually fairly often at larger centers. Cardiovascular abnormalities, because of elastin deficiency, are the leading cause of morbidity and mortality in patients with Williams syndrome. The present article presents a review of the most recent developments regarding the cardiovascular issues in Williams syndrome. Recent findings Cardiovascular abnormalities occur in 80% of patients with Williams syndrome, the majority of which are arterial stenoses. The stenoses seen in Williams syndrome now appear to arise from deficient circumferential arterial growth. Pharmacological therapies aimed at improving the vascular stenoses have shown some promise in animal models. Surgical outcomes for supravalvar aortic stenosis are good at most centers. Transcatheter interventions are largely ineffective in Williams syndrome. Multilevel surgical pulmonary artery reconstruction has excellent results for peripheral pulmonary artery stenosis. Periprocedural risk stratification and management algorithms may decrease the risk of cardiovascular complications. Summary Cardiovascular abnormalities are a major determining factor in the clinical picture and trajectory of patients with Williams syndrome. Advances in surgical techniques, medical therapeutic options, and periprocedural management hold promise for significant improvements in the cardiovascular outcomes of these patients.
Who Gains More: Experts or Novices? The Benefits of Interaction Under Numerical Uncertainty

Interacting to reach a shared decision is an omnipresent component of human collaboration. We explored the interaction between dyads of individuals with different levels of expertise. The members of the dyads completed a number line task privately, jointly and privately again. In the joint condition, dyad members shared their private estimates and then negotiated a joint estimate. Both dyad members averaged their private individual estimates to determine joint estimates, thereby showing a strong equality bias. Their performance in the joint condition exceeded the performance of the dyad’s best estimator, demonstrating interaction benefit, only when the dyad members had similar levels of expertise and when the averaged dyad performance was sufficiently accurate. At the end of the task, participants rated their level and their partner’s level of competence. Participants were accurate in classifying themselves as the expert or the novice within the dyad. Nevertheless, novices tended to overestimate their ability as they admitted to being less competent but only slightly worse than their expert partner. Experts, instead, believed themselves to be more competent but were humble and considered their performance only marginally better than their partner’s. Overall, these results have important implications for settings in which people with different levels of expertise interact.
Towards a contextually appropriate framework to guide counseling of torture survivors in Sub-Saharan Africa.

INTRODUCTION If the right to rehabilitation is to become a meaningful reality for torture survivors in sub-Saharan Africa, it is necessary that counseling practice be responsive to the contextual and cultural demands of the region. Recent reviews of evidence-based practice with torture survivors are discussed with a focus on those approaches developed and/or tested with torture survivors in sub-Saharan Africa. METHODS The results of a mixed methods study of ongoing torture rehabilitation work are reported. This study incorporated a review of 85 case files of torture survivors treated at torture rehabilitation centers in three countries in sub-Saharan Africa, and in depth interviews with fifteen counsellors and fourteen clients at those same centers. Quantitative data are presented in tabular form supported by uni- and bi-variate statistical analyses as appropriate. Qualitative data are presented in terms of themes identified through emergent coding. RESULTS AND DISCUSSION Help-seeking torture survivors in this region are a diverse and highly symptomatic group, often struggling to survive with their families in precarious circumstances and under ongoing threat. In addition to incorporating key aspects of existing evidence-based practice, counselors also use a range of psychosocial approaches to assist torture survivors to protect and support their families in the face of seemingly overwhelming life challenges. We propose that more systematic methodologies that facilitate the inclusion of the voices of clients and clinicians in ongoing international debates relating to evidencebased practice with torture survivors will enhance the application of such practices in diverse contexts.
Longitudinal Typhoid Fever Trends in India from 2000 to 2015

Abstract. A very high incidence of typhoid was described in studies conducted in urban locations on the Indian subcontinent at the end of the twentieth century. Despite their availability, licensed immunogenic conjugate typhoid vaccines have not been introduced in the national immunization program, in part, because of a lack of understanding of where and for whom prevention is most necessary. Uncertainty regarding the burden of disease is based on the lack of reliable, recent estimates of culture-confirmed typhoid and an observed trend of low isolations of Salmonella Typhi and fewer complications at large referral hospitals in India. In this article, we examine the trends of S. Typhi isolation at three large tertiary care centers across India over 15 years and describe trends of recognized risk factors for typhoid from published literature. There appears to be a decline in the isolation of S. Typhi in blood cultures, which is more apparent in the past 5 years. These trends are temporally related to economic improvement, female literacy, and the use of antibiotics such as cephalosporins and azithromycin. The analysis of trends of culture-confirmed typhoid may not accurately capture the typhoid incidence trends if antibiotic use confounds the burden of disease presenting to larger facilities. Emerging antimicrobial resistance may result in a resurgence of disease if the underlying incidence and transmission of typhoid are not adequately addressed through public health approaches.
Risk factors for acute kidney injury after percutaneous nephrolithotomy

Abstract Percutaneous nephrolithotomy (PNL) is a minimally invasive technique for renal stone removal but can cause renal parenchymal injury. Renal stones can also affect renal function. We evaluated the risk factors for acute kidney injury (AKI) after PNL. The study cohort included 662 patients who underwent PNL. Patient characteristics, preoperative laboratory values, intraoperative data, and stone characteristics were collected. Univariate and multivariate logistic regression analyses were performed to identify risk factors for AKI after PNL. Postoperative outcomes such as hospitalization, intensive care unit admission rate and stay duration, and chronic kidney disease were also evaluated. Of the total study series, there were 107 (16.2%) cases of AKI after PNL (AKI group), and 555 (83.8%) patients who showed no injury (no-AKI group). The risk factors for AKI after PNL were found to be a higher preoperative serum uric acid level [odds ratio (OR) = 1.228; 95% confidence interval (95% CI) = 1.065–1.415; P = . 005], longer operation time (OR = 1.009; 95% CI = 1.004–1.014; P < .001), and intraoperative hypotension (OR = 12.713; 95% CI = 7.762–20.823; P < .001). Hospitalization and intensive care unit stay duration were significantly longer in the AKI group (8.7 ± 5.2 vs 6.6 ± 2.8 days, P < .001; 0.34 ± 1.74 vs 0.07 ± 0.48 days, P = .002, respectively). Chronic kidney disease was also significantly higher in the AKI group (63.6% vs 32.7%, P = .024). As intraoperative hypotension is an important risk factor for AKI after PNL, which leads to poor postoperative outcomes, it should be prevented or managed vigorously during PNL.
Nature contact at school: The impact of an outdoor classroom on children’s well-being

ABSTRACT Nature contact facilitates healthy child development and a disconnect with nature presents potential health risks. This study was designed to test a nature intervention at an elementary school among children. An experimental crossover design was implemented over six weeks; two teachers taught their respective kindergarten classes the daily language arts lesson in either the control (indoor classroom) or nature treatment (outdoor classroom) conditions. Child well-being measures were compared in the two conditions. Teachers’ redirections of child behavior were significantly fewer in the nature condition (t = 2.49, p < 0.05) compared to the control. Also, fewer children were off task in the nature condition on average. There were mixed well-being results; children reported no significance difference in happiness in the two conditions, but teachers reported modest benefit in child well-being in the nature condition. The outdoor classroom is a promising method for increasing nature contact and promoting student well-being.
Neuronal Activation Detection Using Vector Phase Analysis with Dual Threshold Circles: A Functional Near-Infrared Spectroscopy Study

In this paper, a new vector phase diagram differentiating the initial decreasing phase (i.e. initial dip) and the delayed hemodynamic response (HR) phase of oxy-hemoglobin changes ( Δ HbO) of functional near-infrared spectroscopy (fNIRS) is developed. The vector phase diagram displays the trajectories of Δ HbO and deoxy-hemoglobin changes ( Δ HbR), as orthogonal components, in the Δ HbO- Δ HbR polar coordinates. To determine the occurrence of an initial dip, dual threshold circles (an inner circle from the resting state, an outer circle from the peak values of the initial dip and the main HR) are incorporated into the phase diagram for making decisions. The proposed scheme is then applied to a brain-computer interface scheme, and its performance is evaluated in classifying two finger tapping tasks (right-hand thumb and little finger) from the left motor cortex. Three gamma functions are used to model the initial dip, the main HR, and the undershoot in generating the designed HR function. In classifying two tapping tasks, the signal mean and signal minimum values during 0-2.5 s, as features of initial dip, are used. The linear discriminant analysis was utilized as a classifier. The experimental results show that the active brain locations of the two tasks were quite distinctive ( p < 0.05 ), and moreover, spatially specific if using the initial dip map at 4 s in comparison to the map of HRs at 14 s. Also, the average classification accuracy was improved from 59% to 74.9% when using the phase diagram of dual threshold circles.
Compositional Dependence of Phase Selection in CoCrCu0.1FeMoNi-Based High-Entropy Alloys

To study the effect of alloy composition on phase selection in the CoCrCu0.1FeMoNi high-entropy alloy (HEA), Mo was partially replaced by Co, Cr, Fe, and Ni. The microstructures and phase selection behaviors of the CoCrCu0.1FeMoNi HEA system were investigated. Dendritic, inter-dendritic, and eutectic microstructures were observed in the as-solidified HEAs. A simple face centered cubic (FCC) single-phase solid solution was obtained when the molar ratio of Fe, Co, and Ni was increased to 1.7 at the expense of Mo, indicating that Fe, Co, and Ni stabilized the FCC structure. The FCC structure was favored at the atomic radius ratio δ ≤ 2.8, valence electron concentration (VEC) ≥ 8.27, mixing entropy ΔS ≤ 13.037, local lattice distortion parameter α2 ≤ 0.0051, and ΔS/δ2 > 1.7. Mixed FCC + body centered cubic (BCC) structures occurred for 4.1 ≤ δ ≤ 4.3 and 7.71 ≤ VEC ≤ 7.86; FCC or/and BCC + intermetallic (IM) mixtures were favored at 2.8 ≤ δ ≤ 4.1 or δ > 4.3 and 7.39 < VEC ≤ 8.27. The IM phase is favored at electronegativity differences greater than 0.133. However, ΔS, α2, and ΔS/δ2 were inefficient in identifying the (FCC or/and BCC + IM)/(FCC + BCC) transition. Moreover, the mixing enthalpy cannot predict phase structures in this system.
Comparison of Pharmacy Claims and Electronic Pill Bottles for Measurement of Medication Adherence Among Myocardial Infarction Patients

Background: Medication adherence after myocardial infarction remains low. Pharmacy claims have typically been used to measure medication adherence, but electronic pill bottles may offer additional information. Objective: The main objectives of this study were to compare the association of adherence measured by prescription claims and remote monitoring technologies with cardiovascular events. Research Design: This study was a secondary analysis of a remote monitoring intervention to increase medication adherence in myocardial infarction patients. Subjects: In total, 682 myocardial infarction patients were randomized to the intervention group with both medical and pharmacy benefits. Measures: Pharmacy claims adherence was measured using proportion of days covered (PDC) and GlowCap adherence (GC) was measured as the proportion of days the pill bottle was opened. We compared the association of PDC and GC adherence for statins with time to first vascular readmission or death and assessed model fit using Akaike information criterion and Bayesian information criterion and the likelihood ratio test. Results: Higher PDC was significantly associated with a lower hazard rate for vascular readmissions or death (hazard ratio=0.435; P=0.009). There was also an association between GC adherence and vascular readmissions or death (hazard ratio=0.313; P⩽0.001). Adding the GC adherence variable to the model using only PDC improved the model fit (likelihood ratio test, P=0.001), as well as vice versa (P=0.050). Conclusions: Pharmacy claims data provide useful but not complete data for medication adherence monitoring. New wireless technologies have the potential to provide additional data about clinical outcomes.
Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism.

BACKGROUND & OBJECTIVE Metabolic syndrome (MetS) is an interconnected group of physiological, biochemical, clinical and metabolic factors that directly increase the risk of cardiovascular disease, type 2 diabetes mellitus (T2DM) and mortality. Rising evidence suggests that MetS plays a significant role in the progression of Alzheimer's disease and other neurodegenerative diseases. Nonetheless, the factors linking this association has not yet been elucidated. As we are facing an increasing incidence of obesity and T2DM in all stages of life, understanding the association of MetS and neurodegenerative diseases is crucial to lessen the burden of the disease. CONCLUSION In this review, we will discuss the possible mechanisms which may relate the association between MetS and cognitive decline which include vascular damages, elevation of reactive oxygen species (ROS), insulin resistance and low-grade inflammation.
Anti‐TNF‐α restricts dengue virus‐induced neuropathy

Proinflammatory TNF‐α facilitates dengue virus (DENV) infection in endovascular dysfunction and neurotoxicity. The introduction of TNF‐α blocking therapy with Abs is performed to test its therapeutic effect in this study. In DENV‐infected mice, TNF‐α production in the brain accompanied the progression of neurotoxicity and encephalitis. DENV infection caused the loss of hippocampal neurons with TNF‐α expression around damaged regions, and immunostaining showed the induction of apoptosis in hippocampal neurons. TNF‐α was expressed in active microglia and astrocytes in DENV‐infected mice. TNF‐α facilitated DENV‐induced neurotoxicity in vitro in murine Neuro‐2a cells. Using a currently established encephalitic mouse model in which DENV infection causes progressive hunchback posture, limbic seizures, limbic weakness, paralysis, and lethality 7 days postinfection, we showed that TNF‐α transgenic mice represented the progressive disease development and administration of neutralizing TNF‐α Ab reduced dengue encephalitis and mortality. These results demonstrate an immunopathogenesis of TNF‐α for mediating DENV‐induced encephalitis‐associated neurotoxicity and that targeting TNF‐α can be used as a strategy against dengue encephalitis.
Increased brain iron deposition in patients with sickle cell disease: an MRI quantitative susceptibility mapping study.

Progressive white matter disease, especially silent cerebral infarction (SCI), is a major problem in sickle cell disease (SCD). 1,2 Although the risk of symptomatic ischemic stroke has been reduced by chronic transfusion therapy and hydroxyurea, the prevalence of SCI in SCD patients continues to be 1% to 2% per age year with no plateau.2 Many studies have focused on the structural and hemodynamic aspects of SCI,3-5 but few have examined brain iron accumulation6,7 and its possible role in reinforcing white matter injury. Brain iron has been shown to increase with recurrent ischemia-reperfusion injuries,8,9 chronic hypoxia,10,11 and microvasculaturedamage,12 which are common conditions in SCD.13,14 As a consequence, excessive brain iron could potentially aggravate white matter damage15,16 and accelerate neurodegeneration.12