Miracle-dz/UniFAR-FTUs huggingface dataset:
Epidermal growth factor dependent phosphorylation of a 35-kilodalton protein in placental membranes.

In human placental membranes isolated in the presence of ethylenediaminetetraacetic acid (EDTA), epidermal growth factor (EGF) stimulated the [gamma-32P]ATP-dependent phosphorylation of tyrosine residues on the 170-kilodalton (kDa) EGF receptor and on a 35-kDa protein. The initial rate of phosphorylation of these proteins in the presence of EGF was 5.2 and 3.5 nmol of phosphate min-1 (mg of receptor protein)-1, and this was approximately 10- and 6-fold higher than the basal rate, respectively. Half-maximal phosphorylation of both proteins occurred at about 2.5 nM EGF. In the presence of p-nitrophenyl phosphate, EGF stimulated the phosphorylation of the 35-kDa protein but not the EGF receptor, suggesting that hormone-stimulated autophosphorylation of the receptor/kinase was not required for kinase activation. The 35-kDa protein exists in two forms: (1) 35Keluate, which was associated with the membrane in the presence of Ca2+ but was eluted with EDTA, and (2) 35Kmemb, which was not eluted from membranes with EDTA. Both forms were immunologically related to a 35-kDa protein previously isolated from A431 cells. Antiserum against the 35-kDa protein also reacted with a protein with an apparent size of 66 kDa that was phosphorylated in an EGF-dependent manner. In phosphorylation reactions performed in the presence of Mg2+, Ca2+ was required for phosphorylation of the 35Keluate form, but Ca2+ was not required for phosphorylation of the 35Kmemb form. Phosphorylation appears to change the membrane-binding properties of the 35Kmemb form because 32P-labeled 35Kmemb could be eluted from the membrane by EDTA. (ABSTRACT TRUNCATED AT 250 WORDS)
Pat hogenic and pandemic Vibrio parahaemolyticus detection in fish and shellfish isolates

In this study, one hundred and seventy isolates of V. parahaemolyticus from marine water fish and shellfish were analyzed by PCR for the presence of tdh and trh virulence genes and toxRS region pandemic gene. The tdh and trh gene was detected in 55.3% and 0.59% of isolates respectively; whereas, toxRS region was detected in 34.1% isolates. Findings of the present study suggested that marine water fish and shellfish isolates of V. parahaemolyticus harbor pathogenic as well as pandemic genes which may serve as source for clinical infection through food chain. [K eywords: Vibrio parahaemolyticus, tdh-gene, trh-gene, toxRS region, GS- PCR].
Nanoelectroablation of human pancreatic carcinoma in a murine xenograft model without recurrence

We have identified an effective nanoelectroablation therapy for treating pancreatic carcinoma in a murine xenograft model. This therapy initiates apoptosis in a nonthermal manner by applying low energy electric pulses 100 ns long and 30 kV/cm in amplitude to the tumor. We first identified the minimum pulse number required for complete ablation by treating 30 tumors. We found that the minimum number of pulses required to ablate the tumor with a single treatment is between 250 and 500 pulses. We settled on a single application of either 500 or 1,000 pulses to treat pancreatic carcinomas in 19 NIH‐III mice. Seventeen of the 19 treated tumors exhibited complete regression without recurrence. Three mice died of unknown causes within 3 months after treatment but 16 lived for 270–302 days at which time we sacrificed them for histological analysis. In the 17 untreated controls, the tumor grew so large that we had to sacrifice all of them within 4 months.
Effectiveness of physical therapy for pregnancy-related low back and/or pelvic pain after delivery: A systematic review

The aim of this work was to investigate the effectiveness of physical therapy for the treatment of low back pain (LBP) and pelvic girdle pain (PGP) related to pregnancy after delivery. A systematic review of studies published since 1985 in the databases Medline, PEDro, SciELO, SCOPUS, LILACS, and the Cochrane Library was made. Studies that focused on postpartum LBP or PGP, without being related to pregnancy or in other non-pregnant patients, were excluded, as were papers addressing LBP or PGP indicating radiculopathy, rheumatism, or any other serious disease or pathologic condition. In accordance with the exclusion criteria and duplicate articles, of the 105 articles retrieved only six were considered for quality assessment with the PEDro Scale. Among these six papers, two were follow-ups, such that only four trials were included in this review. All trials used exercise for motor control and stability of the lumbopelvic region, but with different intervention approaches. The study affording the best evidence used individual guidance and adjustments given by the physiotherapists. Nevertheless, this systematic review was inconclusive and showed that more randomized clinical trials, with good quality, are needed.
Quality management and business excellence.

An excellent organization involves much more than the implementation and the certification of one or more models of management systems. It means developing techniques and tools of busin excellence which lead the organization to outstanding performance on quality, costs and deadlines in order to meet the expectations of all their stakeholders. Such an approach is needed especially in the context of an economy marked by globalization, extremely complex and dynamic that causes spectacular changes in the business environment by integrating quality management principles on purpose to develop sustainable excellence.
The Nature of the 660-Kilometer Upper-Mantle Seismic Discontinuity from Precursors to the PP Phase

Global Seismic Network data were used to image upper-mantle seismic discontinuities. Stacks of phases that precede the PP phase, thought to be underside reflections from the upper-mantle discontinuities at depths of 410 and 660 kilometers, show that the reflection from 410 kilometers is present, but the reflection from 660 kilometers is not observed. A continuous Lamé's constant λ and seismic parameter at the 660-kilometer discontinuity explain the missing underside P reflections and lead to a P-wave velocity jump of only 2 percent, whereas the S-wave velocity and density remain unchanged with respect to previous global models. The model deemphasizes the role of Lamé's constant λ with regard to the shear modulus and constrains the mineralogical composition across the discontinuity.
The autopsy and epidemiology ‐ Olmsted County, Minnesota and Malmo, Sweden

The existence of high quality, population‐based, medical data facilitates the practice of modern epidemiology with its concomitant benefits for clinical practice and public health policy. Two exceptional examples of such databases are provided by Malmo, Sweden, and Olmsted County, Minnesota. This paper outlines briefly the similarities between these two geographic entities, and focuses, in particular, on the central role of the autopsy in Olmsted County. Changing temporal and spatial patterns of autopsy are reviewed as well as two important related issues: the role of consent and the medico‐legal autopsy. The paper concludes with a summary of some of the more noteworthy contributions of autopsy‐based epidemiological research in Olmsted County, and offers several recommendations for the establishment of a select network of special population‐based study areas. These epidemiological “laboratories”, through the interchange of data and tissue specimens, could make significant contributions to the study of diseases both nationally and internationally. Their interactive efforts and high quality data bases would help to increase the efficiency of the expenditure of scarce societal resources in epidemiology and health care.
Data warehouse for detection of occupational diseases in OHS data.

BACKGROUND Occupational health and safety (OHS) services collect a wide range of data during health surveillance. AIMS To build a 'data warehouse' to make OHS data available for research and to investigate sector-specific health problems. METHODS Medical data were extracted, transformed and loaded into the data warehouse. After validation, data on lifestyle, categorized medication use, ICD-9-CM encoded sickness absences and health complaints, collected between 2010 and 2014, were analysed with logistic regression to compare proportions between employment sectors, taking into account age, gender, body mass index (BMI) and year of examination. RESULTS The data set comprised 585000 employees. Average age and employment seniority were 39 ± 12 and 8 ± 9 years, respectively. BMI was 26 ± 5 kg/m(2). Health complaints, medication use and sickness absence significantly increased with BMI and age. The proportion of employees with health problems was highest in health care (64%), government (61%) and manufacturing (60%) and lowest in the service sector. In all sectors, 10% of workers reported locomotor health problems, apart from the service sector (8%) with similar results for medication consumption. Neuropsychological drugs were more frequently used by health care workers (8%). The transport sector contained the highest proportion of cardiological medication users (12%). Finally, 30-59% of employees reported at least one sickness absence episode. Sickness absence due to locomotor issues was highest in manufacturing (11%) and health care (10%), followed by government (9%) and construction (9%). CONCLUSIONS Significant differences in indices of workers' health were observed between sectors. This information is now being used in the implementation of a sector-oriented health surveillance programme.
Global Imbalances from the Historical Perspective

»Globale Ungleichgewichte aus historischer Perspektive«. This paper examines the global imbalances in two eras of globalization. The main focus is on the medium-run factors that determine the current account balances. The results suggest that relatively rich countries with developed financial markets, high quality institutions and high proportion of dependent persons tend to run current account deficits (or lower surpluses) in both periods. On the other hand, the high initial level of net foreign assets increases the current account balance. This holds especially in the prewar period. The government budget balance has a positive effect on the current account balance in some instances. In the prewar period, the government budget balance plays the role only in the short-run, suggesting the importance of the short-run fluctuations in the current account balance. The twin deficits hypothesis plays a more important role in the second era of the globalization. However, it holds only for developing countries. These results suggest that the twin deficit hypothesis and the global savings glut hypothesis are not mutually exclusive.
Genomic instability in patients with autosomal-dominant polycystic kidney disease

Objective Autosomal-dominant polycystic kidney disease (ADPKD) is a systemic disorder affecting multiple organs that results in renal and extrarenal cysts. Patients with ADPKD may have genomic instability, making them more vulnerable to developing cancer. This study aimed to investigate latent genomic instability in patients with ADPKD, using single-cell gel electrophoresis (comet assay). Methods The susceptibility of peripheral blood lymphocytes to DNA damage induced by X-ray treatment (0.5 Gy) was tested in 20 patients with ADPKD using single-cell gel electrophoresis. The percentage of DNA in the comet tail (TDNA%) before and after irradiation was compared between patients with ADPKD and 20 sex- and age-matched healthy control subjects. Results Renal and extrarenal cysts were observed in patients with ADPKD. A significantly higher mean TDNA% was determined in patients with ADPKD compared with control subjects (8.85% versus 7.50%). After in vitro irradiation, DNA damage was significantly increased in all participants, but the increase was significantly greater in patients with ADPKD compared with control subjects. Conclusion These data suggest that patients with ADPKD have genomic instability, which may trigger renal and extrarenal cyst formation.
Biblical and Talmudic medicine.

julius preuss biblical and talmudic medicine ccsplc biblical and talmudic medicine zyvpdf.ijoy365 biblical and talmudic medicine user manuals by hayashi suzune judaism post biblical and talmudic period cgymw a talmudic perspective on old testament diseases health care in the bible and the talmud curationis otology in the bible and talmud cambridge university press proposal for centers for the study of biblical psychotherapy is there life after life? superfetation in medical gary b. ferngren, medicine and religion: a historical books on judaism and health encyclopedia of medicine in the bible and the talmud by kidney and urinary tract disease in ancient babylonia “partial birth abortion” and the question of when human esoteric healing traditions:aconceptual overview koshertorah – online school for advanced biblical medicine in ancient hebrew and jewish cultures jacob’s injury: differential diagnosis of hip pathology aufstieg und niedergang der romischen welt (anrw) rabbinics judaism and health: re? ections on an emerging jsij 10 (2012) 71-93 biu medicine the history ofsneezing bmj history of ophthalmology researchgate eye of the beholder: ophthalmic illness in talmudic literature medicine the history ofsneezing researchgate god and nature: readings on the encounter between jewish medical collectors case western reserve university medical practices of ancient near east robin cohn talmudic methodology and aristotelian logic: david ibn health and medicine in the jewish tradition (review) the turkey who ate my father elosuk 3)it,6tiixg *dtieyg of new rutgers university libraries history of posttalmudic rabbinic literature booklet african journal of urology ajolfo medical malpractice in jewish law -final ssrn principles of talmudic logic studies in talmudic logic yamaha hs50m user manual expoll obstetrics and the curse of eve hakirah edward isaac reichman speakers bureau the lillie goldstein traveling judaica collection mettle of the pasture opalfs
Antisense RNA‐mediated transcriptional attenuation: an in vitro study of plasmid pT181

Antisense RNAs regulate plasmid replication by several different mechanisms. One of these mechanisms, transcriptional attenuation, was first described for the staphylococcal plasmid pT181, and later for the streptococcal plasmids pIP501 and pAMβ1. Previously, we performed detailed in vitro and in vivo analyses of the pIP501 system. Here, we present an in vitro analysis of the antisense system of plasmid pT181. The secondary structures of antisense and sense RNA species of different lengths were determined. Binding rate constants for sense/antisense RNA pairs were measured, and functional segments required for complex formation were determined. A single‐round transcription assay was used for in vitro analysis of transcriptional attenuation. A comparison between pT181 and pIP501 revealed several differences; whereas a truncated derivative of pIP501 antisense RNA was sufficient for stable complex formation, both stem–loop structures of pT181‐RNAI were required. In contrast to the sense RNA of pIP501, which showed an intrinsic propensity to terminate (30–50% in the absence of antisense RNA), the sense RNA of pT181 required antisense RNA for induced termination. Rate constants of formation of pT181 sense–antisense RNA complexes were similar to inhibition rate constants, in striking contrast to pIP501, in which inhibition occurred at least 10‐fold faster than stable binding.
Transcriptome analyses suggest a disturbance of iron homeostasis in soybean leaves during white mould disease establishment.

Sclerotinia sclerotiorum is a serious pathogen of numerous crops around the world. The major virulence factor of this pathogen is oxalic acid (OA). Mutants that cannot produce OA do not cause disease, and plants that express enzymes that degrade OA, such as oxalate oxidase (OxO), are very resistant to S. sclerotiorum. To examine the effect of OA on plants, we infiltrated soybean leaves with 5 mm OA and examined the gene expression changes at 2 h post-infiltration. By comparing the gene expression levels between leaves of a transgenic soybean carrying an OxO gene (OxO) and its parent AC Colibri (AC) infiltrated with OA (pH 2.4) or water (pH 2.4 or 5.5), we were able to compare the effects of OA dependent or independent of its pH. Gene expression by microarray analysis identified 2390 genes that showed changes in expression, as determined using an overall F-test P-value cut-off of 0.001. The additional requirement that at least one pairwise t-test false discovery rate (FDR)-corrected P value should be less than 0.001 reduced the list of the most highly significant differentially expressed genes to 1054. Independent of pH, OA altered the expression levels of 78 genes, with ferritin showing the strongest induction by OA. The combination of OA plus its low pH caused 1045 genes (99% of all significant genes) to be differentially expressed, with many of the up-regulated genes being related to basal defence, such as genes of the phenylpropanoid pathway and various cytochrome P450s. RNA-seq was also conducted on four samples: OxO and AC genotypes infiltrated with either OA pH 2.4 or water pH 2.4. The RNA-seq analysis also identified ferritin paralogues as being strongly induced by OA. As the expression of ferritin, a gene that encodes for an iron storage protein, is induced by free iron, these results suggest that S. sclerotiorum benefits from the ability of OA to free iron from plant proteins, as this induces host cell death, and also allows the uptake and assimilation of the iron for its own metabolic needs.
SocLab: A Framework for the Modeling, Simulation and Analysis of Power in Social Organizations

This paper is a comprehensive presentation of a framework for the modeling, the simulation and the analysis of power relationships in social organizations, and more generally in systems of organized action. This framework relies on, and slightly extends, the Crozier and Freidberg's sociology of organized action, which supports a methodology for understanding why, in an organizational context, people behave as they do. SocLab intends to complement the discursive statement of sociological analyses with a formal formulation easing the objectivization of findings. It consists of a meta-model of organizations, a model of bounded-rational social actors and analytical tools for the study of the internal properties of organizations.
Determinants of Management Ownership of Unrestricted Equity: Overconfidence Versus Tax Explanations

We document frequent and large selling of equity by CEOs. Such selling is designed not simply to offset the current year grant of options and stock. We find that the tax burden associated with the sale and (various measures of CEO) overconfidence both decrease CEOs' propensity to sell their vested equity. However, the effect of taxes on a CEO's decision to sell equity is far more pronounced than overconfidence. We also find that taxable institutional investors and CEOs both respond to taxes, although the CEOs appear to be less tax-sensitive. Other determinants affect the selling decisions largely as predicted in the existing literature.
Volatility and Mean Spillover of Chinese ADRs at New York Stock Exchange

This paper examines how the returns and volatility of Chinese ADRs listed at NYSE are affected by their host market (US), underlying market (Hong Kong) and local market (Shanghai). Using a GARCH spillover model and data from 1 January 2002 to 30 September 2007, we find that the volatility spillover from US (host market), Hong Kong (underlying market) and Shanghai (local market) to Chinese ADRs, following the order: Hong Kong > US > Shanghai which can also be reflected in variance ratios. The increasing impact from host market and local market may attribute to strengthened integration between Chinese market and world market after China entered WTO. For US investors, they may need to be more prudent in diversification by using Chinese ADRs. However, there is relatively weak mean spillover from US (host market), Hong Kong (underlying market) and Shanghai (local market) to Chinese ADRs. Chinese ADRs including China Mobile Ltd. experience mean spillover from Hong Kong, whereas no mean spillover is found in Chinese ADRs excluding China Mobile Ltd. This difference may due to closer relationship between Hong Kong market and China Mobile Ltd. Finally, we find symmetric responses in Chinese ADRs to upturns and downturns as well as the positive shocks and negative shocks in the US, Hong Kong and Shanghai markets.
Balloon Valvuloplasty and Angioplasty in Pediatric Practice

Copyright: © 2011 Rao PS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Congenital heart defect (CHD) is the most common congenital anomaly in children and constitutes approximately 1% of live births. This will result in nearly 35,000 babies born with heart defects in the USA alone. Nearly 50% of these babies can be managed with simple medications, observation and follow-up without any major therapeutic intervention. However, the remaining 50%, in the past, required surgical, some under cardiopulmonary bypass, intervention. Since the advent of transcatheter techniques, 50% of these babies can be managed with less invasive, percutaneous, transcatheter techniques. In this editorial the role of balloon valvuloplasty and angioplasty in the management of children with CHDs will be reviewed.
Uninsured Unemployment Risk and Optimal Monetary Policy

I study optimal monetary policy in a New Keynesian economy wherein house- holds precautionary-save against uninsured, endogenous unemployment risk. In this economy greater unemployment risk raises desired savings, causing aggregate demand to fall and ul- timately feed back to greater unemployment risk. I show this deationary feedback loop to be constrained-ine¢ cient and to call for an accommodative monetary policy response: after a contractionary aggregate shock the policy rate should be kept signi cantly lower and for longer than in the perfect-insurance benchmark. For example, the usual prescription obtained under perfect insurance of a hike in the policy rate in the face of a bad supply (i.e., productivity or cost-push) shock is easily overturned. If implemented, the optimal policy e¤ectively breaks the deflationary feedback loop and takes the dynamics of the imperfect-insurance economy close to that of the perfect-insurance benchmark.
Gene expression and phenotypic change in Paramecium tetraurelia exconjugants.

A study of the patterns of phenotypic change in exconjugants using the recessive behavioural mutant pawn ( pwA ) and its wild-type allele shows that both cytoplasmic and nuclear factors contribute to phenomic lag. Following loss of the wild-type allele from the macronucleus, phenomic lag lasts for 6–11 cell cycles in various sublines of a single clone. Inherited cytoplasmic material is estimated to be responsible for phenomic lag of no more than 5–6 cell cycles. Longer persistence of the parental phenotype is due to continued gene activity in macronuclear fragments carrying the wild-type allele. Genes in fragments remain active and can result in maintenance of the parental phenotype as long as fragments are present (up to 11 cell cycles). Phenomic lag in the other direction, from pawn to wild type, varies from 0 to 2 cell cycles. The major cytoplasmic factor involved is the amount of wild-type material acquired from the mate during conjugation. Extensive cytoplasmic exchange often occurs during normal conjugation and can lead to change of phenotype as early as the first meiotic division. Phenotypic change due to gene expression in macronuclear anlagen brings about phenotypic change near the end of the first cell cycle in +/+ cells and about a cell cycle later in heterozygotes.