Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of hypertension induced by sorafenib in advanced renal cell carcinoma

Objective: To investigate the incidence and management of hypertension induced by sorafenib in patients with advanced renal cell carcinoma, and to evaluate the relationship between hypertension and the response to sorafenib. Methods: The incidence of blood pressure in 30 patients with advanced renal cell carcinoma treated with sorafenib was calculated and the severity of hypertension was classified as grade 1 to grade 5. The corresponding antihypertensive therapy was conducted and the change of blood pressure after treatment was observed. The predictive value of hypertension for the response to sorafenib was evaluated by using univariate analysis. Results: The median time from the initiation of sorafenib treatment to the occurrence of sorafenib-induced hypertension in 30 patients with advanced renal cell carcinoma was 15 d (range: 6-58 d). The incidence of sorafenib-induced hypertension was 30.0% (9/30). In these 9 patients, most (88.9%) of them were classified as grade 1 to grade 2 of hypertension. The hypertension was controlled well after corresponding antihypertensive treatment. No serious cardiac events or hypertensive crisis were observed. The dose of sorafenib was not reduced or the sorafenib treatment was not interrupted due to the uncontrolled hypertension. Univariate analysis revealed that sorafenib-induced hypertension was not a significant predictor for the response to sorafenib (χ2=0.635，P=0.637). Conclusion: The incidence of sorafenib-induced hypertension during the treatment of advanced renal cell carcinoma is high, but the severity of this hypertension is mostly mild or moderate, and the response to antihypertensive treatment is satisfying. The sorafenib-induced hypertension is not a predictor for the response to sorafenib. DOI:10.3781/j.issn. 1000-7431.2012. 05.013
Trends of poisoning in chandigarh a six year autopsy study

A six-year study (1994–1999) of total medico-legal autopsies conducted at Govt. Medical College, Chandigarh, revealed a continuous increase in deaths due to poisoning. Number of deaths due to poisoning which were placed third amongst all unnatural causes behind Road Side Accidents (RSA) & Burns till 1997, became second after RSA in 1998 & ultimately topped the list in the year 1999.
Assessment of Patient Expectation at Islamic Hospital Surabaya, Indonesia

Satisfaction during a health care encounter is related to the relationship between the patients’ expectations and experiences. Relevant problem areas include failure to consider the patient’s personal importance weighting of different aspects of hospital stay, insufficient operationalisation of expectation fulfilment This study aimed to understand the expectation of the customers with respect to quality of delivered health care services. A cross sectional study of 64 patients was carried out, at the Islamic Hospital Surabaya, Indonesia. Patients were offered at random to participate in the study. A questionnaire, based on the study objectives was developed and administered. This study found that patient satisfaction generally on health services in Islamic Hospital Surabaya is good (68.8%). Nevertheless, there are patient choose not bad (7,8%). Majority of the patients are satisfied with the services provided. except: cleanliness aspect of the parking, the cleanliness of the bathroom, the settlement of complaints, and the waiting time of service. So patient expectation on hospital management to improve health services in hospital, on parking, bathroom, complaints and waiting time. We suggest a pragmatic conceptual model designed to clarify the process of expectation development
CADICAL at the SAT Race 2019

Our SAT solver CADICAL provides a clean, documented, easy to understand and modify state-of-the-art solver, based on CDCL [1] with inprocessing [2]. Earlier versions participated in the SAT competition 2017 and 2018. Here we only describe differences to these versions [3], [4]. Even though CADICAL performed well on unsatisfiable instances in the SAT Competition 2018, the performance on satisfiable instances was behind the top solvers in that competition. Thus a large part of the changes made and described in this note are motivated by trying to improve CADICAL on satisfiable instances without loosing its good performance on unsatisfiable instances.
Top Management Team Pay Disparities and Financial Reporting Complexity

I examine the impact of pay disparity between the chief executive officer (CEO) and the next layer of executives in the top management team (TMT) on financial reporting complexity. I find that firms with larger TMT pay disparities exhibit more complex annual reports. The main findings are robust to corrections for endogeneity. I find some evidence that the positive relation is more pronounced for firms with larger pay gaps, lower stock performance, lower institutional ownership, and CEO duality. I also find that larger pay disparities (more complex reports) are associated with lower operating performance (greater CEO compensation) in the subsequent period. Collectively, my evidence suggests that TMT pay disparity increases the complexity of written financial communications by providing the CEO with the incentive to justify the pay inequity and/or lowering the efficiency of information processing within firms. This study provides useful insight into the distribution of executive pay and its effects on corporate financial disclosures.
BCG status in children with tuberculosis: A multicenter study in northern Nigeria

Background : Bacille Calmette.Guerin (BCG) vaccine has been in use since 1921, yet childhood TB is still very prevalent in Nigeria. Since BCG efficacy depends in part on appropriate vaccine utilization, this study was designed to investigate the current practice of BCG administration through determination of BCG status. Methodology : Consecutive HIV negative children with new diagnosis of tuberculosis disease attending five outpatient clinics in Northern Nigeria were recruited over 2 years. Using a structured questionnaire, information with regards to their BCG status was obtained and each child was examined for the presence of a BCG scar. Logistic regression was performed to identify determinants of BCG status. Results : There were 300 children aged between 1 month and 14 years. More than half of them (mainly residing in rural and semiurban areas) did not receive BCG and only one.third (49/138) of those vaccinated had identifiable BCG scars. Delivery at home was significantly associated with non.receipt of the BCG antigen (OR = 408, z =5.891, P < 0.001). Lack of BCG vaccination was a significant factor for extra pulmonary disease (ƒO2 = 37.34, OR = 11, P = 0.0001); with a four.fold increase in relative risk. Logistic regression showed that lack of a BCG scar correlated significantly with vaccination in non.governmental facilities (P = 0.006), positive tuberculin skin test (TST) values (P < 0.0001) but not with extra pulmonary disease (P = 0.909). Conclusion : Childhood TB is still driven to a large extent by low BCG coverage. In a TB endemic region, the absence of a BCG scar in a symptomatic child is an indicator for TB screening.
Cuidando de idosos com Alzheimer: a vivência de cuidadores familiares

Alzheimer’s disease compromises an elderly person’s functional capacity, increasing his or her need for assistance. This study aimed to better understand processes involved in caring for elders with dementia. A descriptive, transversal method was used; data were collected between August, 2005 and August 2006. In-home interviews were conducted with family caregivers for demented elders (N = 14), service users at a school for healthcare practices. The data were analyzed using Bardin´s model for Content and Theme Analysis. The results show that the majority of caregivers confuse the onset of the disease with normal aging processes. As the disease progresses, the elders’ dependence levels increase. The elders’ behavior changes have a strong emotional impact on their caregivers. Some key factors that affect the caregiving experience include the stage of the disease, the strength of the family support network and family history.
The Effectiveness of Training in Task Switching

The authors of this chapter describe changes in task-switching abilities over the life span. In particular, task maintenance and selection processes decline in older age. The authors summarize conditions under which the flexibility and plasticity of these processes can be improved such as external and internal prompts to behavior and intensive practice. The effectiveness of task-switching training interventions is evaluated by highlighting conditions under which transfer effects to other cognitive abilities are more likely to occur such as training variability. The author also discuss the usefulness of strategy-based interventions, the impact of inter-individual differences in baseline performance, and the specific role of motivation on the success of training in task switching.
Digesting the Profitability and Investment Premiums

This paper highlights the effects of short selling activity on the profitability and investment premiums. Recently, Fama and French (2015) extend their three-factor asset pricing model by adding profitability and investment factors. Using short interest as a proxy to measure the short selling activity, we find that the stocks without shorting show significant higher profitability premium, while short selling activity has no impact on the investment premium. We also provide evidence that the profitability premium is more likely than the investment premium to be associated with the sentiment-driven mispricing, and short sellers are skilled at eliminating sentiment-driven mispricing. Collectively, our results suggest that the two new Fama-French factors have different underlying attributions. While the profitability premium is more consistent with cash flow-based interpretation, the investment premium is more consistent with risk-based interpretations.
Chirurgie cardiaque chez l'hémodialysé chronique: résultats immédiats et à long terme.

De 1979 a 1993, 50 patients en hemodialyse chronique ont beneficie de 53 interventions de chirurgie cardiaque dans le service. L'âge moyen etait de 56±13 ans. Il y avait 33 hommes et 17 femmes. La duree moyenne de l'hemodialyse preoperatoire etait de 82±63 mois. La duree moyenne des symptomes cardiaques avant l'intervention etait de 35±52 mois. Vingt-sept patients (54%) etaient en classe fonctionnelle NYHA (New York Heart Association) III ou IV preoperatoire. Seize patients (32%) avaient une fraction d'ejection ventriculaire gauche preoperatoire au-dessous de 0,40. Douze patients (24%) ont ete operes en urgence. L'intervention a consiste en chirurgie coronaire isolee chez 29 patients, remplacement valvulaire aortique isole chez 13 patients avec reflux pour 1, chirurgie de remplacement valvulaire mitral chez 3 patients avec reflux pour deux, chirurgie combinee chez 5 patients. Le temps de clampage aortique moyen etait de 75±32 minutes, le temps de circulation extracorporelle moyen etait de 125±50 minutes. Pour les patients coronariens, la revascularisation chirurgicale a ete consideree comme incomplete dans 37% des cas du fait de la gravite de la maladie coronaire sous-jacente. Le saignement postoperatoire moyen a ete 800±650 ml, 29 patients (58%) ont ete transfuses avec une moyenne de 4,3±3 culots globulaires. La mortalite precoce globale a ete de 9 patients (18%): 10% chez les coronariens, 7% dans les remplacements valvulaires aortiques, 50% pour les procedures plus complexes. Les causes de mortalite ont ete cardiaques (n=4), septiques (n=2), et defaillance polyviscerale (n=3). La morbidite a ete de 39%, essentiellement par bas debit cardiaque. Le sejour moyen en reanimation a ete de 6,6±8 jours, a l'hopital de 13±7 jours. La survie actuarielle a 1, 5 et 10 ans a ete respectivement de 68, 40 et 40%. Les 14 deces tardifs ont ete d'origine cardiaque (n=4), septique (n=4), par defaillance polyviscerale (n=4) ou de nature inconnue (n=2). Les facteurs pronostiques mis en evidence par l'analyse univariee ont ete la classe fonctionnelle NYHA preoperatoire III-IV, l'existence d'une hypertension arterielle pulmonaire preoperatoire, un temps de clampage aortique allonge. Les resultats devraient pouvoir etre ameliores par une detection active plus precoce des signes cardiaques et une intervention rapide avant la deterioration de l'etat general chez ces dialyses chroniques, directement en rapport avec l'anciennete des dialyses preoperatoires
Does Information Disclosure Matter in Competitive Industries?

We examine the effect of information disclosure on firm performance across different levels of product market competition. Using a unique and comprehensive information rating scheme based on 114 measures over five dimensions of information disclosure at each publicly listed firm in Taiwan from 2005 to 2013, we find that firms with more information disclosure experience higher firm performance. However, this positive relationship tends to apply to firms in industries where competition is strong. Our findings suggest that the governance role of disclosure is most influential in an environment that also fosters greater competition. It offers another reason why competition is important for corporate governance in addition to its disciplinary role. JEL Classification: G30
Do Capital Market Value Corporate Social Responsibi l ty? Evidence from Seasoned Equity Offerings

This paper explores whether firms' corporate social responsibility (CSR) activities provide added value to the capital market participa nts through seasoned equity offerings (SEO). SEO represents a cleaner exogenous activity which alleviates reverse causality issue that plagues many prior studies examining the relat ion between firm performance and CSR. Using a large sample of SEO in the US, we find that high CSR issuers experience fewer negative market reactions to SEO announcements. We also show that ethical issuers have incentive to provide extensive and informative disc lo ures, which mitigate the degree of information asymmetry, and thereby leading to a dec rease in SEO underpricing. Our findings remain robust after controlling for possible self-s election bias and endogeneity problems. Overall, our findings support the stakeholder value maximization view of stakeholder theory and ethical theory.
THE IMPACT OF STRUCTURAL TRANSFORMATION ON ENVIRONMENTAL POLLUTION: EVIDENCE FROM ASIAN COUNTRIES

This paper examines the impact of structural transformation on environmental pollution in selected Asian countries for the years 1990–2015. This transformation decomposes into technological progress, structural changes, demographic changes and trade openness. We analyse the extended stochastic impacts by employing the regression on population, affluence, and technology (STIRPAT) model. Findings suggest that the industrialization process will induce increased environmental pollution, while the teritarization process lowers environmental pollution. Further, the results support the existence of an inverted-U curve between affluence level and CO emissions and urbanization and CO emissions, implying that at a higher scale of the economy, environmental pollution decreases. Nevertheless, as the scale of the economy becomes large, environmental pollution cannot be counter balanced by the positive impact of tertiarization effect. In addition, we found an interesting result by accounting for a range of demographic dynamics; the results show that an increase in aging population contributes to carbon emission increment. This study not only sheds light on existing literature, but it also provides policy makers with insightful information on how to promote growth and sustainability development policies .
Acid-base and Electrolyte Teaching Case A 90-Year-Old Man With Hyperphosphatemia

Hyperphosphatemia is a common condition in patients with decreased kidney function, and without treatment, it can lead to a variety of clinical consequences. However, the presence of hyperphosphatemia in patients with normal kidney function may be true or spurious. We present a case of pseudohyperphosphatemia in a patient with monoclonal gammopathy. An increased paraprotein level can lead to colorimetric interference of the assay of phosphate measurement and result in spurious hyperphosphatemia. The epidemiologic and clinical characteristics of paraprotein-associated pseudohyperphosphatemia also are reviewed here. Ultrafiltration of paraproteins or deproteinization can help correct the measuring error. Patients with spurious hyperphosphatemia should not be treated with phosphate binders. Clinicians treating patients with monoclonal gammopathy should be aware of this relatively common clinical phenomenon and avoid inappropriate treatment of spurious hyperphosphatemia. Am J Kidney Dis. 57(2):342-346. © 2011 by the National Kidney Foundation, Inc.
BIODEGRADATION OF THE AZO DYE (REMAZOL BLACK B) BY Pseudomonas putida ISOLATED FROM TEXTILE WASTEWATER SAMPLE

The synthetic aromatic compounds, Azo dyes, which have one or more –N=N– groups, are the most important and largest class of the used dyes with commercial applications especially in food and textile industries. The cleaning of textile wastewater containing dyes has attracted much attention in the recent years. The present study is an attempt to determine the ability of some bacterial isolates obtained from textile wastewater sample from Al Khumra station for decolorization of the Azo dye, Remazol black B. Three bacterial isolates were isolated from wastewater of textile effluents containing azo dye on basal nutrient medium. These isolated bacterial isolates were identified as Bacillus cereus, B. pumilus and Pseudomonas putida by phylogenetic analysis of their 16S rDNA. The most promising bacterial isolate was Pseudomonas putida and was used for further study. Results of study revealed that P. putida have ability of complete biodegradation (100%), if concentration is at 400 ppm while this degradation was 60 and 30 percent at 600 and 700 ppm concentration of azo dye respectively. Further, rate of biodegradation also depend on the pH and temperature of the surrounding medium, at 400 ppm concentration of azo dye, maximum degradation was obtained at pH 6.5 and temperature 40°C. This decolorization potential increased the applicability of this bacterium for the dye removal and the results suggest that the obtained isolate of P. putida can be used as a useful tool to treat waste water containing Azo dyes. Degradation potential of the bacterium depend on the presence of azoreductases, laccases and peroxidases enzymes. * Corresponding author KEYWORDS
Menstrual hygiene among married women: a hospital based cross-sectional study in an urban slum of Mumbai, India

Background: Reproductive tract an infection which has become a silent epidemic that devastates women’s life is closely interrelated with poor menstrual hygiene. The aim and objective of the study was to know the pattern of various menstrual hygiene practices and its association with STI/RTI among married females. Methods: A cross sectional study was carried out in STI/RTI Clinic of Urban Health Centre, Shivaji Nagar, Govandi, Mumbai, involving total 273 married females who attended OPD from January to March 2012. Patients were interviewed on the basis of pretested and preformed questionnaire. Confirmation of STI/RTIs was based on the symptoms as well as disease specific laboratory investigations. Results: About 35 (79.5%) females presented with STI/RTI who were practicing sex during menstruation. Problem of STI/RTI was found less in 143 (60.9%) those practicing shaving of pubic hair. Other personal hygiene practices during menses like washing genitals with soap and water, taking bath during menses were found to be helpful in reducing these infections. STI/RTIs were low in 32 (55.7%) females who were using disposable pads as compared to 95 (71.4%) females who were using reuse cloth during menses. Cleaning practices of reuse cloth were significantly associated with STI/RTI. Conclusions: The menstrual hygiene practices and its frequency associated with STI/RTI.
Post-Split Underreaction : The Relevance of Prior Split History

We document that the level of underreaction, or long-term positive abnormal returns, following a stock split depends on the number of splits that have already occurred. The largest underreaction follows firms’ first, second and third split announcements and then decreases (but remain significantly positive) with each successive split until the fifth split. The sixth and subsequent splits display returns that are no different from zero. Splitting firms demonstrate superior profitability than similar firms in the year following the first three splits, but then reverts to more normal levels following the fourth and later splits. Consistent with the information signalling hypothesis, the improved operating performance following a split is associated with abnormal returns. However, splitting firms cannot consistently outperform similar firms beyond the third split. Splitting stocks experience no significant changes in illiquidity following each split confirming that our findings are not explained by microstructure effects. Our results suggest that the efficacy of a signal steadily reduces each time the signal is sent. JEL Classification: G14, G35
Factors affecting female entrepreneurial intentions in Kabul, Afghanistan

Female Entrepreneurship is an emerging phenomenon allover the world. It has even more importance in the context of least developed economies like Afghanistan. In Afghanistan, overall situation in terms of social and cultural as well as political and geographical aspects is different from other countries around the world. Female participation in business and their public presence is some thing very new here in Afghanistan. This study presents an empirical analysis of the factors affecting female entrepreneurial intentions in Kabul, Afghanistan. The current study employs quantitative methodology. The sampling frame for this study is 60 female owned registered enterprises in Kabul, Afghanistan (ACCI, 2015). A 5point’s likert scale is used as survey instrument to collect the data from the respondents. Pull and push factors theory is considered as an underlying theory for this research. The research concluded that the input variables; economical factors and motivation play a significant role in affecting entrepreneurial intentions in Kabul city, while the other input variables; socio-cultural and security factors do not significantly impact the outcome variable i.e. entrepreneurial intentions. The study also found out that the independent variables bring 73% changes in the dependent variable. The research study recommends the formalization and promotion of female entrepreneurial activities in Afghanistan. In addition, similar studies should be conducted in other parts of the country to validate the findings from this study.