Miracle-dz/UniFAR-FTUs huggingface dataset:
PROGNOSTIC SIGNIFICANCE OF CD56 EXPRESSION IN ACUTE LEUKEMIAS

Background. CD56 expression was extensively investigated in cases of acute leukemia. Many studies associated it with short overall survival, unfavorable outcome, lower rates or short complete remission, however the results remain controversial. Objectives. The aim of this study was to investigate the frequency and prognostic relevance of CD56 expression in patients with acute leukemia and to compare its value with other standard prognostic factors, such as age, gender, leukocytosis, morphologic subtypes, extramedullary invasion, cytogenetic abnormalities and performance status. Methods. Forty cases of acute leukemia treated at Ain Shmas University hospitals were investigated. They were classified by the French-American-British group (FAB) criteria, flow cytometry, and cytogenetics data. They included twenty cases of acute myeloid leukemia (AML) and twenty cases of acute lymphoblastic leukemia (ALL). Results. CD56 positive expression was detected in nine cases of AML (45 %), and only in two patients with ALL (10 %). The highest incidence of CD56 positivity was in FAB subtypes M1 (35 %) and M2 (35 %). Association studies between CD56 expression and other prognostic factors in AML cases showed no significant association with age, gender, clinical presentation, hematological data or cytogenetic risk groups. Incidence of relapse was higher in AML patients expressing CD56 than those who did not (66.7 % vs 10 %, P=0.01). Higher death rates were encountered in AML cases with CD56 expression than those without (55.6 % vs 10 %, P=0.032). Conclusions. CD56 antigenic expression in AML cases represents an adverse prognostic factor. It should be regularly investigated in cases of AML for better prognostic stratification and assessment. KEY WORDS: CD56; leukemia, myeloid; prognosis
Evaluation of sinus node automaticity and sinoatrial conduction in children with normal and abnormal sinus node function

Sinus node recovery time (SNRT) and sinoatrial conduction time (SACT) were determined in each of 28 children. Eighteen children (ages 2 to 14 years) had electrocardiographically normal sinus node function and served as controls. Ten children (ages 4 to 13 years) had electrocardiographic evidence of sinus node dysfunction, consisting of inappropriate sinus bradycardia, periods of sinus arrest or sinoatrial exit block. Mean control SNRT was 133% of the sinus cycle length with an upper normal limit of 151% (mean + 2 SD). Control SACTs ranged from 45‐105 ms with mean and mean + 2 SD values of 71 ms und 105 ms.
Inhibitory Processes Training for School-age Children: Transfer Effects

ABSTRACT Inhibition refers to a basic executive component that can be conceptualized as consisted of different inhibitory processes (i.e., perceptual, cognitive and response inhibition). These processes emerge during the first years of life, and since then are involved in different relevant every day activities. Different individual and contextual factors can modulate their developmental trajectories. The possibility of train in separate ways each inhibitory process is a subject of analysis. In such a context, the aims of this work were: (a) to design, implement and evaluate training of perceptual, cognitive and response inhibition processes, in a sample of school-aged children (6 to 8 years old); and (b) to analyze near, far, short- and long-transfer effects. An experimental design with three training groups (one for each inhibitory process) and an active control group was implemented. Near transfer effects were not observed. We found effects on a visuospatial working memory task in the short term, after the training in the response and cognitive inhibition, and effects on a fluid intelligence task in both the short and long term after the training in cognitive inhibition. The results contribute to a conceptualization of multidimensional inhibitory processes and the plausibility of training them during childhood.
Risk of Recurrent Peptic Ulcer Disease in Patients Receiving Cumulative Defined Daily Dose of Nonsteroidal Anti-Inflammatory Drugs

The purpose of this population-based case–control study was to clarify the impact of cumulative dosage of nonsteroidal anti-inflammatory drugs (NSAIDs) on recurrent peptic ulcers among chronic users after Helicobacter pylori (H. pylori) eradication. We analyzed data of 203,407 adult peptic ulcer disease (PUD) patients from the National Health Insurance Research Database in Taiwan entered between 1997 and 2013. After matching for age/gender frequencies and the length of follow-up time in a ratio of 1:1, the matched case–control groups comprised 1150 patients with recurrent PUD and 1150 patients without recurrent PUD within 3 years of follow-up. More recurrent PUDs occurred in NSAID users than in the control group (75.30% versus 69.74%; p = 0.0028). Independent risk factors for recurrent PUD included patients using NSAIDs (adjusted OR (aOR): 1.34, p = 0.0040), H. pylori eradication (aOR: 2.73; p < 0.0001), concomitant H2 receptor antagonist (aOR: 1.85; p < 0.0001) and anti-coagulant (aOR: 4.21; p = 0.0242) use. Importantly, in the initial subgroup analysis, the risk ratio of recurrent PUD did not increase in NSAID users after H. pylori eradication compared with that in non-users (p = 0.8490) but a higher risk for recurrent PUD with the increased doses of NSAIDs without H. pylori eradication therapy (aOR: 1.24, p = 0.0424; aOR: 1.47, p = 0.0074; and aOR: 1.64, p = 0.0152 in the groups of ≤28, 29–83, and ≥84 cumulative defined daily doses, respectively). The current study suggested that H. pylori eradication therapy could decrease the risk of recurrent PUD among patients with high cumulative doses of NSAIDs.
Unilateral Adrenalectomy for Primary Bilateral Macronodular Adrenal Hyperplasia: Analysis of 71 Cases

Abstract Objective Primary bilateral macronodular adrenal hyperplasia (PBMAH) is characterized by benign bilateral enlarged adrenal masses, causing Cushing’s syndrome (CS). The aim of the current article is to define the role of unilateral adrenalectomy (UA) in treating patients with CS related to PBMAH. Methods A PubMed database search was conducted to identify articles reporting UA to treat PBMAH. We also report cases of PBMAH from our medical center treated by UA. Results A total number of 71 cases of PBMAH (62 cases reported in the literature and 9 cases from our center) are presented. Most patients were women (73.2%) and most UA involved the left side (64.3%). In most cases, the resected gland was the larger one. Following UA, 94.4% of cases had remission of hypercortisolism. Recurrence rate of CS was 19.4% and hypoadrenalism occurred in 29.6%. After UA, when the size of the remained adrenal gland was equal or greater than 3.5 cm, CS persisted in 21.4% of cases, and recurrence occurred in 27.3% of cases (after 20±9.2 months). However, when the size of the remained gland was less than 3.5 cm, CS resolved in all cases and recurrence occurred in 21.2% of cases after a long period (65.6±52.1 months). High levels of urinary free cortisol (UFC) were not correlated with post-surgical CS recurrence or persistence. Conclusions UA leads to beneficial outcomes in patients with CS related to PBMAH, also in cases with pre-surgical elevated UFC or contralateral large gland.
Dietary Patterns, Exercise, and the Metabolic Syndrome Among Young People in Urban Pakistan (Lahore).

Background: Increasing urbanization, mechanization, and rural-to-urban migration has led to deranged sleeping patterns, surplus energy intake, and sedentary lifestyles in South Asian young people. This shift poses an insidious health risk for the development of metabolic syndrome (MetS). Early detection is needed because in the South Asian population, this syndrome carries an increased risk of comorbidities compared to people without the syndrome. This study was designed to elucidate the prevalence of MetS and its risk factors in young people in urban areas of Pakistan. Methods: A cross-sectional study was conducted in four undergraduate institutions in Lahore, Pakistan. Five hundred and nine young people participated, and each provided their informed consent for the collection of data on their demographic, physical, and biochemical characteristics along with information on their dietary, sleep, and physical activity habits. Results: Most participants reported consuming greater-than-recommended amounts of protein and smaller-than-recommended amounts of vegetables and fruits. The International Diabetes Federation criteria for MetS were fulfilled by 6.1% of the students. Hypertension (67.7%) and hypo-HDL-emia (64.5%) were the most common risk factors. More than 50% of the respondents slept fewer hours per day than recommended, and 33% had a sedentary lifestyle. Men, participants with a family history of metabolic illness and those with low physical activity levels had higher odds of a positive result on screening for MetS. Conclusions: The early detection of MetS and early identification of probable risk factors may make beneficial contributions to both public health and clinical interventions directed at high-risk individuals. Establishing and using cutoff values for modified waist circumference and specific body mass index in Asian populations may aid in early detection.
Naked mole-rats reduce the expression of ATP-dependent but not ATP-independent heat shock proteins in acute hypoxia

ABSTRACT Naked mole-rats are one of the most hypoxia-tolerant mammals identified, and putatively experience intermittent and severe hypoxia in their underground burrows. Systemic physiological adaptions to hypoxia have begun to be investigated in this species; however, the cellular adaptations that underlie this tolerance remain poorly understood. Hypoxia compromises cellular energy production, and the maintenance of protein integrity when ATP generation is limited poses a major challenge. Heat shock proteins (HSPs) are cellular chaperones that are cytoprotective during hypoxia, and we hypothesized that their expression would increase during acute hypoxia in naked mole-rats. To test this hypothesis, we used qPCR and western blot approaches to measure changes in gene and protein expression, respectively, of HSP27, HSP40, HSP70 and HSP90 in the brain, heart, liver and temporalis muscle from naked mole-rats following exposure to normoxia (21% O2) or hypoxia (7% O2 for 4, 12 or 24 h). Contrary to our expectations, we observed significant global reductions of ATP-dependent HSP70 and HSP90 (83% and 78%, respectively) after 24 h of hypoxia. Conversely, the expression of ATP-independent HSP27 and HSP40 proteins remained constant throughout the 24-h hypoxic treatment in brain, heart and muscle. However, with prolonged hypoxia (24 h), the expression of Hsp27 and Hsp40 genes in these tissues was also reduced, suggesting that the protein expression of these chaperones may also eventually decrease in hypoxia. These results suggest that energy conservation is prioritized over cytoprotective protein chaperoning in naked mole-rat tissues during acute hypoxia. This unique adaptation may help naked mole-rats to minimize energy expenditure while still maintaining proteostasis in hypoxia. Summary: In acute hypoxia, the regulation of heat shock proteins in naked mole-rats indicates prioritization of energy conservation over proteostasis.
Perceived neighborhood social disorder as a predictor of depressive symptoms among unmarried older women and the stress-buffering effect of friends support

ABSTRACT The current study examined whether perceived neighborhood social disorder predicted depressive symptoms among unmarried older women (N = 823) drawn from the 2016 Health and Retirement Study. This study also tested the stress-buffering effect of friends support. A negative binomial regression model showed that higher perceived neighborhood social disorder was associated with higher depressive symptoms. The number of close friends was a significant factor, but no stress-buffering effect of friends support was identified. This study highlights the adverse effect of negative perceptions of the neighborhood social environment on unmarried older women’s depressive symptoms.
Surgical anatomy of vascularized submental lymph node flap: Sharing arterial supply of lymph nodes with the skin and topographic relationship with anterior belly of digastric muscle

Development of vascularized submental lymph node (VSLN) flap has encountered dilemmas; (a) whether to include skin paddle, (b) how to reduce the harvest area while gaining most lymph nodes. To answer, these structures were studied; submental perforator, lymph nodes in neck‐level I and anterior belly of digastric muscle (ABDM).
Effects of adding dexmedetomidine to local infiltration of bupivacaine on postoperative pain in pediatric herniorrhaphy: a randomized clinical trial

Background Postoperative pain is a major problem, especially in children, as their tolerance level is lower and several drugs are contraindicated in childhood. This study aimed to compare the effect of dexmedetomidine added to local infiltration of bupivacaine for postoperative pain relief in children undergoing inguinal herniorrhaphy. Methods This double-blind, randomized clinical trial included 60 children aged 6–72 months undergoing unilateral herniorrhaphy at selected hospitals in Shiraz, Iran, randomly allocated into two groups, 30 in each group. One group received 1 µg/kg dexmedetomidine plus local infiltration of 0.2 ml/kg bupivacaine 0.5% at the incision site before surgery (BD), and the other group received bupivacaine and normal saline (BO). Analgesic requirements, emergence time, and nausea/vomiting, postoperative pain and sedation scores were assessed for 4 h after the operation. Heart rate (HR), systolic blood pressure (SBP), and oxygen saturation (SaO2) were recorded at baseline, and at 10 and 20 min after injection. Results Eighty percent were boy in each group; mean age was 22.75 ± 18.63 months. SaO2 and SBP were not different between the groups, while HR was significantly lower in the Group BD at 10 and 20 min after injection (P < 0.05). Group BD had a lower pain score at 1 and 2 h after the operation, a higher sedation score at the first three time intervals, and longer emergence time than Group BO (all P < 0.001). Group BD had a lower pain score at 1 and 2 h after the operation (P < 0.001, P < 0.047 respectively). Conclusions Addition of dexmedetomidine to local infiltration of bupivacaine in children undergoing herniorrhaphy significantly reduced postoperative pain and increased sedation.
Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia.

β-thalassemia is a genetic anemia caused by partial or complete loss of β-globin synthesis leading to ineffective erythropoiesis and RBCs with short life-span. Currently, there is no efficacious oral medication modifying anemia for patients with beta-thalassemia. The inappropriately low levels of the iron regulatory hormone hepcidin enable excessive iron absorption by ferroportin, the unique cellular iron exporter in mammals, leading to organ iron overload and associated morbidities. Correction of unbalanced iron absorption and recycling by induction of hepcidin synthesis or treatment with hepcidin mimetics ameliorates β-thalassemia. However, hepcidin modulation or replacement strategies currently in clinical development all require parenteral drug administration. We identified oral ferroportin inhibitors by screening a library of small molecular weight compounds for modulators of ferroportin internalization. Restricting iron availability by VIT-2763, the first clinical stage oral ferroportin inhibitor, ameliorated anemia and the dysregulated iron homeostasis in the Hbbth3/+ mouse model of beta-thalassemia intermedia. VIT-2763 not only improved erythropoiesis but also corrected the proportions of myeloid precursors in spleens of Hbbth3/+ mice. VIT-2763 is currently developed as an oral drug targeting ferroportin for the treatment of β-thalassemia.
Measuring the Fate of Compost-Derived Phosphorus in Native Soil below Urban Gardens

The heavy reliance on compost inputs in urban gardening provides opportunities to recycle nutrients from the urban waste stream, but also creates potential for buildup and loss of soil phosphorus (P). We previously documented P in leachate from raised-bed garden plots in which compost had been applied, but the fate of this P is not known. Here, we measured P concentrations in soils below four or six-year-old urban garden plots that were established for research. We hypothesize that the soil P concentration and depth of P penetration will increase over time after gardens are established. Soil cores were collected in five garden plots of each age and quantified for inorganic weakly exchangeable P. Inorganic weakly exchangeable P was significantly elevated in native soil below garden plots (>35 cm deep) relative to reference soil profiles, and excess P decreased with increasing depth, although differences between garden plots of different ages were not significant. Our analysis shows that excess P from compost accumulates in native soil below urban garden plots. While urban agriculture has the potential to recycle P in urban ecosystems, over-application of compost has the potential to contribute to soil and water pollution.
Disparities in healthcare providers’ interpretations and implementations of ACIP’s meningococcal vaccine recommendations

ABSTRACT Invasive meningococcal disease (IMD) caused by the bacteria Neisseria meningitidis is rare but potentially fatal. For healthy adolescents, the US Advisory Committee on Immunization Practices (ACIP) recommends routine vaccination with MenACWY and recommends MenB vaccination under shared clinical decision-making (previously “Category B”). The recommendation for MenB vaccination was the first category B recommendation in adolescents, and it is unclear how healthcare providers (HCPs) implement these guidelines. This 2017 web-based survey of US HCPs explored characteristics associated with prescribing or receiving MenB and MenACWY vaccines, HCP knowledge of vaccine recommendations, and real-world practice patterns. Of 529 respondents, 436 prescribed MenB vaccines to their eligible adolescent/young adult patients and 93 prescribed MenACWY vaccines only. MenB vaccine prescribers were more likely to be pediatricians compared with MenACWY vaccine only prescribers, and patients who received MenB vaccines were more likely to be non-Hispanic whites living in shared spaces (eg, college dormitories) than those not receiving the vaccine. Seventy-seven percent of HCPs indicated that they prescribe MenACWY vaccines consistently with ACIP recommendations (to all members of an age group), whereas only 7% indicated that they prescribe MenB vaccines consistently with ACIP recommendations (individual clinical decision making). Patient-related factors, disease-related factors, and guidelines all influenced HCP decisions to prescribe meningococcal vaccines. Providing HCPs with clear guidance on how to initiate discussion of MenB vaccines with patients and their caregivers may aid in fully protecting US adolescents against meningococcal disease caused by 5 of the disease-causing serogroups.
Psf3 as a possible biomarker of postoperative chemotherapy for patients with early pulmonary adenocarcinoma

Partner of Sld five 3 (Psf3) is a member of the heterotetrameric complex that consists of SLD5, Psf1, Psf2, and Psf3. We have shown in previous studies that high Psf3 expression was a poor prognostic marker for pulmonary adenocarcinoma. Here, we statistically evaluated the relationship between clinicopathologic factors and Psf3 expression in stage I pulmonary adenocarcinoma.
Secure Communication Based on Quantized Synchronization of Chaotic Neural Networks Under an Event-Triggered Strategy

This article presents a secure communication scheme based on the quantized synchronization of master–slave neural networks under an event-triggered strategy. First, a dynamic event-triggered strategy is proposed based on a quantized output feedback, for which a quantized output feedback controller is formed. Second, theoretical criteria are derived to ensure the bounded synchronization of master–slave neural networks. With these criteria, an explicit upper bound is given for the synchronization error. Sufficient conditions are also provided on the existence of quantized output feedback controllers. A Chua’s circuit is chosen to illustrate the effectiveness of our theoretical results. Third, a secure communication scheme is presented based on the synchronization of master–slave neural networks by combining the basic principle of cryptology. Then, a secure image communication is studied to verify the feasibility and security performance of the proposed secure communication scheme. The impact of the quantization level and the event-triggered control (ETC) on image decryption is investigated through experiments.
Feasibility of tumor-derived exosome enrichment in the onco-hematology leukemic model of chronic myeloid leukemia

Due to the discovery of their role in intra-cellular communications, exosomes, which carry information specific to the cell of origin, have garnered considerable attention in cancer research. Moreover, there is evidence to suggest the possibility of isolating different exosome sub-populations based on target antigens at the cell surface. Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasia characterized by the break-point cluster region-proto-oncogene 1 tyrosine-protein kinase (BCR-ABL1) fusion-gene, derived from the t (9;22) translocation. Tyrosine kinase inhibitors (TKIs) target BCR-ABL1 protein and induce major or deep molecular responses in the majority of patients. Despite the fact that several studies have demonstrated the persistence of leukemic cells in the bone marrow niche, even following treatment, TKIs prolong patient survival time and facilitate treatment-free remission. These characteristics render CML a plausible model for investigating the feasibility of tumor-derived exosome fraction enrichment. In the present study, patients in the chronic phase (CP) of CML were treated with TKIs, and the quantification of the BCR-ABL1 exosomal transcript was performed using digital PCR (dPCR). The possibility of tumor-derived exosomes enrichment was confirmed, and for the first time, to the best of our knowledge, the detection of the BCR-ABL1 transcript highlighted the presence of active leukemic cells in patients with CP-CML. According to these findings, tumor-derived exosomes may be considered a novel tool for the identification of active leukemic cells, and for the assessment of innovative monitoring focused on the biological functions of exosomes in CML.
Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism

Abstract Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some adult humans, residuals of brown adipose tissue are adjacent to the central nervous system and acute activation increases metabolic rate. Brown adipose tissue (BAT) recruitment occurs during cold acclimation and includes secretion of factors, known as batokines, which target several different cell types within BAT, and promote adipogenesis, angiogenesis, immune cell interactions, and neurite outgrowth. All these processes seem to act in concert to promote an adapted BAT. Recent studies have also provided exciting data on whole body metabolic regulation with a broad spectrum of mechanisms involving BAT crosstalk with liver, skeletal muscle, and gut as well as the central nervous system. These widespread interactions might reflect the property of BAT of switching between an active thermogenic state where energy is highly consumed and drained from the circulation, and the passive thermoneutral state, where energy consumption is turned off. (Endocrine Reviews 41: XXX – XXX, 2020)