Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of metabolism, excretion and pharmacokinetics of a single dose of [14C]-ZD6126 in patients with solid malignant tumors

3083 Background: ZD6126 is a novel vascular-targeting agent that causes disruption of the microtubular network responsible for maintaining the shape of immature, proliferating endothelial cells in tumor vasculature. This leads to selective vessel occlusion and extensive tumor necrosis. Methods: A Phase I excretion balance study of ZD6126 has been conducted in 6 patients (47–56 yrs) with solid tumors refractory to standard therapies, a WHO performance status of 0–2 and a life expectancy of ≥12 weeks. Those with significant cardiac, hematopoietic, hepatic or renal dysfunction were excluded. Patients received a single 10 min infusion of 40 mg/m2 [14C]-ZD6126 (70 μCi; 2.6 MBq) on day 1 of a 28-day cycle. Urine and feces were collected continuously for the first 8 days and blood samples were collected on days 1 and 2. Subsequent treatment comprised a single i.v. infusion of ZD6126 (56 mg/m2). Results: Pharmacokinetic analysis showed that Cmax for plasma ZD6126 was observed 5 min into the 10 min infusion. Conce.
Spectral Analysis Of Nonlinear Operators

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Antimicrobial Effect of Different Sizes of Nano Zinc Oxide on Oral Microorganisms

Objectives: The purpose of the present study was to evaluate the antimicrobial effect of various sizes and concentrations of zinc oxide (ZnO) nanoparticles on Streptococcus mutans (S. mutans), Enterococcus faecalis (E. faecalis), Lactobacillus fermentum (L. fermentum), and Candida albicans (C. albicans). Materials and Methods: Solutions at the concentration of 10 μg/ml were prepared using 20-nm, 40-nm, and 140-nm nano ZnO (nZnO) powder. The antimicrobial effect of nZnO was determined using the disk diffusion method. The inhibition zone (mm) was measured using a ruler. Data were analyzed by analysis of variance (ANOVA) and the Bonferroni correction. The minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of nZnO were determined using the broth microdilution method in Mueller-Hinton Agar (MHA) for S. mutans and E. faecalis, De Man, Rogosa, and Sharpe (MRS) agar, and Sabouraud Dextrose Agar (SDA). Results: The greatest inhibition zones were observed against S. mutans with 20-nm and 40-nm nZnO, while 140-nm nZnO formed the greatest inhibition zones against S. mutans and E. faecalis. The smallest inhibition zones were observed against C. albicans with the three nZnO particle sizes. The MICs for C. albicans with 40-nm and 140-nm particles and for L. fermentum with 140-nm particles were higher than 10 μg/ml. A significant correlation was found between the particle size and the antibacterial activity against S. mutans (P=0.00), L. fermentum, and E. faecalis (P<0.02). Conclusion: The antimicrobial activity of nZnO increases with decreasing the particle size. The greatest antimicrobial effect was observed against S. mutans and E. faecalis. S. mutans is more sensitive to the changes in the particle size compared to other bacteria.
Cancellation of Surgeries by the Patient, Doctor or Institution: An Approach to Legal Ethical Aspects

INTRODUCTION: The cancellation of surgery represents a dilemma in establishing relatively adequate cancellation rates according to the factor, because each institution and surgical specialty have different dynamics. Objective: Describe the types of factors present for the cancellation of surgeries in a health institution. Colombia (2017-2018). METHODOLOGY: Descriptive, retrospective, cross-sectional study. We reviewed (3339) records of scheduled surgeries from January to December 2017. In 2018 they were reviewed (1733) between January and June. A total of (5072) records of a Third Level Health Institution of the Department of Cesar / Colombia were reviewed. The Neuronal Multilayer Perceptron Network model and the Gini coefficient were applied to determine the most important factor and therefore the inequality between them. RESULTS: In 2017, there was a surgical cancellation rate of 4% of the total number of scheduled surgeries (3339). For the year 2018, the rate was 3% of the total of scheduled surgeries (1733). The most important factor was due to the patient's adverse conditions. The surgical specialties that had the highest number of cancellations were general surgery followed by orthopedics. CONCLUSION: An evaluation of the factors for the cancellation of programmed surgeries with a high coefficient of inequality is described. In addition, the most important factor was related to the patient. Prospective studies by specialty are proposed for the design of solution and monitoring strategies to avoid surgical cancellations.
Assessing the impact of food insecurity on HIV medication adherence in the context of an integrated care programme for people living with HIV in Vancouver, Canada

Abstract Objective: Food insecurity, or self-reports of inadequate food access due to limited financial resources, remains prevalent among people living with HIV (PLHIV). We examined the impact of food insecurity on combination antiretroviral therapy (cART) adherence within an integrated care programme that provides services to PLHIV, including two meals per day. Design: Adjusted OR (aOR) were estimated by generalized estimating equations, quantifying the relationship between food insecurity (exposure) and cART adherence (outcome) with multivariable logistic regression. Setting: We drew on survey data collected between February 2014 and March 2016 from the Dr. Peter Centre Study based in Vancouver, Canada. Participants: The study included 116 PLHIV at baseline, with ninety-nine participants completing a 12-month follow-up interview. The median (quartile 1–quartile 3) age was 46 (39–52) years at baseline and 87 % (n 101) were biologically male at birth. Results: At baseline, 74 % (n 86) of participants were food insecure (≥2 affirmative responses on Health Canada’s Household Food Security Survey Module) and 67 % (n 78) were adherent to cART ≥95 % of the time. In the adjusted regression analysis, food insecurity was associated with suboptimal cART adherence (aOR = 0·47, 95 % CI 0·24, 0·93). Conclusions: While food provision may reduce some health-related harms, there remains a relationship between this prevalent experience and suboptimal cART adherence in this integrated care programme. Future studies that elucidate strategies to mitigate food insecurity and its effects on cART adherence among PLHIV in this setting and in other similar environments are necessary.
Various faces of the same disease: membranous nephropathy in pregnancy - A case series

Introduction. Pregnancies in women with membranous nephropathy (MN) are usually complicated by increased proteinuria and superimposed preeclampsia, and this frequently results in poor pregnancy outcomes. The aim of this paper is to present case series of pregnant women with MN and different fetal and maternal outcomes. Outline of cases. Case 1 presents a 25-year-old woman with MN, who had relapsed nephrotic syndrome in early pregnancy with proteinuria of 4.14 g/day and serum albumin of 30 g/L accompanied by hypertension. Due to a missed abortion, the pregnancy was terminated. Three months later her proteinuria was still increased, measuring 3 g/day. Case 2 presents a 29-year-old woman with a history of diffuse proliferative glomerulonephritis, who conceived with proteinuria below 0.5 g/day. The proteinuria ranged between 1 and 2 g/day from the 32nd until the 38th gestational week, when she delivered a healthy neonate. After delivery, the woman underwent a kidney biopsy, which revealed MN. Case 3 presents a 25-year-old woman with MN, whose proteinuria was 1 g/day at the time of conception, but in the 35th gestational week proteinuria of 4.2 g/day was noticed. In the 36th gestational week, increased proteinuria was detected, and a cesarean section was performed with favorable neonatal outcome. After two weeks her proteinuria dropped to 0.6 g/day. Conclusion. Pregnancies in women with MN associated with low-grade proteinuria at the time of conception may have a favorable perinatal outcome. Such pregnancies require multidisciplinary management by both obstetricians and nephrologists, and team decision regarding the best timing of delivery.
Therapeutic efficacy of Isometamidium chloride in Trypanosomiasis affected cattle

To evaluate the efficacy of Isometamidium chloride, a total of ten (10) crossbred cattle suffering from surra were taken for this study. Trypanosomiasis was confirmed after microscopic detection of Trypanosoma evansi parasite in blood smears of the affected cattle. Affected cattle were treated with Isometamidium chloride injection (@ 0.5 mg/kg bwt IM) along with supportive therapy. Blood and serum samples collected from affected cattle on day 0 (pre-treatment), 3, 7 and 14 (post-treatment) were analysed for haematological and biochemical parameters respectively. Haematological alterations recorded in affected cattle were decreased Hb (8.36 g/dl ± 0.142), PCV (25.91% ± 0.467) and TEC (4.69 ×106/μL ± 0.132) indicating affected were afflicted with anaemia. The observed Leucopenia was accompanied by Lymphocytopenia, Eosinophilia, Neutrophilia and Thrombocytopenia. Similarly biochemical alterations observed in the affected animals were significantly decreased Glucose (34.81 mg/dl ±0.7), Total Protein (5.47 g/dl ± 0.078), Albumin (1.95 g/dl ± 0.055), Globulin (3.52 g/dl ± 0.043) and increased BUN (15.46 mg/dl ± 0.211), Creatinine (0.78 mg/dl ± 0.011 IU/L), ALT (33.9 ± 0.211 IU/L) and AST (123.2 ± 1.62; Table 2). A gradual disappearance of clinical signs with no parasitemia microscopically was recorded on 3 day among all the affected cattle, along with a gradual restoration in the altered haemato-biochemical parameters on different post-treatment observation days. Hence, it was inferred that Isometamidium choride is very effective against T evansi infection in cattle.
Analysis of Satisfaction and Problems of Clinic Radiological Technologist on the Supplementary Education

본 연구는 의원에 근무하는 방사선사의 보수교육에 관한 연구로 보수교육에 대한 만족도와 문제점을 분석하여 보수교육에서 개선하여야 할 사항을 연구하기 위해 실시하였다. 연구에 사용한 도구는 설문지로 2016년 11월 01일부터 2017년 04월30일까지 경남 창원에 소재하는 의원에 근무하는 방사선사를 대상으로 교육참석 및 방문을 통한 조사로 이루어 졌으며,.
Managing the Effects of Poor Sleep Quality in Nurses

Staffing shortages, high turnover rates, and prolonged work shifts has caused decreased sleep quality in nurses due to fatigue. The fatigued nurse causes concern for safety, coordination and agility, patient avoidance, lack of compassion, impaired cognitive function, risk for chronic diseases, and patient care errors. This systematic research review was designed to identify evidence-based practice nursing interventions currently being used to manage the effects of reduced sleep quality. Methods for performing this systematic research review were to search multiple databases using keywords, scanning article titles and abstracts, and critiquing for relevance and quality. Findings from this systematic review found multiple evidence-based interventions which improved the mental, physical, and spiritual health of the nurse such as dry cupping, knitting, and changes in call schedule. Implications of this review included: education related to management of reduced sleep quality of nurses in undergraduate nursing programs, further research related to napping and duty-free breaks, and the need to create national guidelines for monitoring and managing reduced sleep quality in nurses.
An outcome analysis of intertrochanteric fracture of femur managed with proximal femoral nail antirotation II

Background: Intertrochanteric fractures are common osteoporotic fractures in adults above 60 years with high mortality and morbidity. Common techniques for fixation of these fractures are sliding hip screw and plate or intramedullary nailing. Intramedullary nailing has advantage of short incision, less operative time, rapid rehabilition & thus decreased medical complications. PFNA II is newer intramedullary implant developed to obtain better fixation strength in osteoporotic bones. Biomechanical studies has demonstrated that PFNA II blade has a significance of higher cut out resistance than other commonly used screw systems.Methods: Prospective follow up study carried out at J.L. N. Medical College Ajmer from 1 March 2017 to 31st October 2018. 30 patients with unstable intertrochanteric fractures were included and operated on fracture table in supine position with PFNA2. We measured operative time, duration of hospital stay, modified Harris hip score and complications.Results: The mean age of the patients was 70.83 years of age. The mean time in surgery was 38.2 minutes. The mean amount of blood loss in surgery was 110.8 ml. In implant related complications, 2 patients had cut out and 1 patient had pull - out of the implant. Functional results according to modified Harris hip scores was found to be excellent in 8 (30%) patients, good in 12 (40%) patients, fair in 7 (20%) patients and poor in 3 (10%) patients.Conclusions: Elderly patients treated with PFNA2 has good outcome as less operative time, minimal blood loss, early weight bearing, less union time and very few cases of medial penetration and back out of spiral blade.
The Clinicopathological Effects of the Double Immunization with Formalized Killed Vaccine against Pasteurella multocida Challenge in Rabbits

The disease caused by Pasteurella multocida is an extremely common and difficult issue of rabbits utilized for biomedical research. The vaccination techniques are dependably the most powerful preventive measures. In the present study, 30 New Zealand rabbits (1.5 kg average body weight and 6–8 weeks old) were divided into 3 groups, control group (I), challenged non-vaccinated group (II), and challenged double vaccinated group (III). 1st dose was administered at the 1st day followed by similar booster dose after 21 days. At the end of the 2nd, 4th, and 6th weeks of the experiment, blood samples were collected from the ear vein for hematological, plasma, and serum examination. At the end of the 6th week, the rabbits were anaesthetized and sacrificed to collect the tissue specimens from liver, kidneys, spleen, lungs and heart for histopathological study. The results showed that double immunization with killed vaccine of P. multocida increased the immune response of the animals and the leukocyte phagocytic activity against P. multocidaand also improved the clinicopathological and histopathological findings. Taken together, our findings proved that double immunization with killed vaccine of P. multocida increased the phagocytic activity of the immune cells and the immune status of animals against infection.
Dietary patterns of pregnant women, maternal excessive body weight and gestational diabetes

ABSTRACT OBJECTIVE To investigate the relationship between the dietary patterns of pregnant women with maternal excessive body weight and gestational diabetes mellitus. METHODS A cross-sectional study conducted with a convenience sample of 785 adult pregnant women attended by the Unified Health System of Ribeirão Preto, state of São Paulo, between 2011 and 2012. Two 24-hour dietary recalls, corrected by the multiple source method, were employed . For the classification of the body mass index and the diagnosis of gestational diabetes mellitus, the criteria by Atalah and the World Health Organization were used, respectively. Dietary patterns were obtained by principal component analysis using the Varimax rotation method. The relationship between adherence to patterns, overweight and obesity was analyzed by multinomial logistic regression models and the relationship with gestational diabetes mellitus by adjusted unconditional logistic regression models. RESULTS We identified four dietary patterns: “traditional Brazilian”; “snacks”; “coffee” and “healthy”. Women with a higher adherence to the “Healthy” (OR = 0.52; 95%CI 0.33–0.83) and “Brazilian Traditional” patterns (OR = 0.61; 95%CI 0.38–0.96) presented a lower chance of obesity, when compared to women with lower adherence, regardless of confounding factors. After adjustment for maternal excessive body weight, there was no association between dietary patterns and gestational diabetes mellitus. CONCLUSIONS Among the pregnant women, greater adherence to “traditional Brazilian” and “healthy” patterns was inversely associated with obesity, but no relationship was identified with gestational diabetes mellitus after adjusting for excessive body weight. Prospective studies are recommended to investigate the relationship between dietary patterns, overweight and gestational diabetes mellitus, reducing the chance of reverse causality.
The Space-Time Topography of English Speakers.

English speakers talk and think about Time in terms of physical space. The past is behind us, and the future is in front of us. In this way, we ‘map’ space onto Time. This dissertation addresses the specificity of this physical space, or its topography. Inspired by languages like Yupno (Núñez, et al., 2012) and Bamileke-Dschang (Hyman, 1980), languages that encode temporal events through physical downhill/uphill topography or through fine-grained proximaldistal grammatical forms, this dissertation revisits our understanding of English by asking the extent to which English speakers, too, construe temporal events as physically proximal or distal with relation to a deictic center. Through seven experiments featuring two novel paradigms with physical space both behind and in front of the deictic center, this dissertation shows that English speakers construe Time through fine-grained topographical space, with tomorrow physically closer to a deictic center than next year. Since thought and language are inextricably connected, it also addresses the extent to which grammaticalized constructions, such as future forms (be going to vs. will) and epistemic modal verbs (may vs. might) encode proximal-distal temporal distinctions (Comrie, 1985; Langacker, 2008). English speakers have multiple means of construing fine-grained past or future events, co-locating the present either with the ego (e.g., The past is behind me) or with an external locus, like a square on a calendar (Núñez and Cooperrider, 2013). Therefore, this dissertation also examines the conditions under which English speakers adopt an external deictic center or default to an internal one, essentially demonstrating the contextual flexibility of speakers’ space-time construals. Finally, English speakers have also been shown to recruit representations of physical motion when processing temporal events (e.g., We’re approaching summer) (Boroditsky & Ramscar, 2002). Using a novel paradigm in which participants estimate physical distances behind and in front of them, this dissertation shows that English speakers recruit representations of motion when co-locating the present with the ego, but not when they co-locate the present with an external locus. In these ways, this dissertation serves as a first map of English speakers’ space-time topography, providing a new perspective on the interaction of language and cognition when speakers cognize temporal events.
Outcomes of transcatheter aortic valve replacement in patients with mitral valve regurgitation

Introduction Transcatheter aortic valve replacement (TAVR) is currently considered a class I indication for patients with severe symptomatic aortic stenosis and high/prohibitive surgical risk. Aim We describe the effect of concomitant mitral valve regurgitation (MR) on post-procedural TAVR outcomes. Material and methods The study population was extracted from the 2014 National Readmissions Data (NRD) using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for TAVR, MR and post-procedural outcomes. Propensity matching was used to extract a control group of TAVR patients without MR (TAVR-C) to the TAVR with concomitant MR group (TAVR-MR). Study outcomes included in-hospital all-cause mortality, in-hospital post-procedural stroke, acute myocardial infarction (AMI), bleeding, mechanical complications of prosthetic valve, vascular complications (VC), need for new permanent pacemaker implantation (PPM) and 30-day readmission rates. Results A total of 1511 patients were identified in each group (mean age: 81.7 years, 49.3% male); the two groups were comparable in terms of baseline characteristics and co-morbidities. When compared to TAVR-C, TAVR-MR was associated with lower post-procedural stroke (3.5% vs. 5.2%, p = 0.03). There was no significant difference between groups in terms of all-cause mortality (4.1% vs. 4.5%, p = 0.59), AMI (3.2% vs. 2.9%, p = 0.59), bleeding (33.4% vs. 35.6%, p = 0.19), mechanical complications of prosthetic valve (2.5% vs. 1.9%, p = 0.31), VC (3.2% vs. 4.4%, p = 0.06), the need for PPM (7.9% vs. 9.1%, p = 0.21) or 30-day readmission rates (19.0% vs. 19.1%, p = 0.95). Conclusions TAVR-MR was associated with lower post-procedural stroke but comparable other in-hospital outcomes and 30-day readmission rates to TAVR-C.
The Expression of Definitions in Specialised Texts: a Corpus-based Analysis

This paper explores the notion that terms are often, either explicitly or implicitly, defined or explained in certain types of texts. I argue that defining can be described as a performative action when, to paraphrase, Austin, the circumstances are felicitous. I describe the felicity conditions which must be met in order for statements to be considered as partial definitions or explanations of terms. The work outlined in this paper forms part of a broader investigation into the possibility of producing spec­ ifications for the (semi-) automatic identification and retrieval of terminological definitions from corpora.
Adesão aos equipamentos de proteção individual entre trabalhadores de saúde que sofreram acidentes com material biológico/ Adherence to standard precautions among health care workers exposed to accidents with biological material

Objetivo: Analisar a adesao aos Equipamentos de Protecao Individual entre trabalhadores de saude que sofreram acidentes com material biologico. Metodo: Trata-se de um estudo epidemiologico, retrospectivo, quantitativo, realizado em um hospital de media complexidade, no periodo de outubro de 2010 a dezembro de 2013. Resultados: A inadequacao do uso dos Equipamentos de Protecao Individual durante a realizacao do procedimento foi mais prevalente em pessoas com idade ate 29 anos e em profissionais da equipe de enfermagem. O uso incorreto dos equipamentos tambem foi mais prevalente entre as pessoas que sofreram acidentes durante os procedimentos invasivos e com sangue. Conclusao: A baixa adesao ou a inadequacao na utilizacao dos Equipamentos de Protecao Individual foi observada e pode estar vinculada tanto a aspectos individuais como a relacionados as instituicoes empregadoras.