Miracle-dz/UniFAR-FTUs huggingface dataset:
Olfactory Ensheathing Cells Do Not Exhibit Unique Migratory or Axonal Growth-Promoting Properties after Spinal Cord Injury

Olfactory ensheathing cells (OECs) have been reported to migrate long distances and to bridge lesion sites, guiding axonal regeneration after spinal cord injury (SCI). To understand mechanisms of OEC migration and axonal guidance, we injected lamina propria OECs 1 mm rostral and caudal to C4 SCI sites. One month later, OECs formed an apparent migrating cell tract continuously extending from the injection site through the lesion, physically bridging the lesion. Confocal immunolabeling demonstrated that, whereas this cell tract displaced host astrocytes, descending or ascending long tract axons did not preferentially extend into the cell tract and OECs failed to support bridging of corticospinal axons. Notably, the “bridging” tract of OECs formed within 1 h of cell injection, raising the possibility that cells passively spread from the pressure injection site rather than actively migrating. Control injections of bone marrow stromal cells (MSCs) or fibroblasts 1 mm from the lesion site also rapidly dispersed into the lesion cavity. Cell tracts extending into the lesion site were not seen when cells were injected either at low volumes, into spinal cord gray matter, or 3 d before or 9 d after SCI. OECs proliferated in injection sites, cell tracts, and lesion sites, indicating that OECs can also accumulate through cell proliferation. Thus, OECs do not appear to exhibit significant migratory properties when grafted to the spinal cord, exhibit no detectable difference in promoting axon growth into a SCI site compared with MSCs or fibroblasts, and do not support bridging of corticospinal axons beyond a dorsal column lesion.
Reply to Connor and Lande on Cartel Overcharges

Abstract John Connor and Robert Lande have written a detailed critique of my review article, “The Empirical Basis for Antitrust: Cartels, Mergers, and Remedies,” published in this Journal earlier in the year. Connor and Lande apparently misunderstand the purpose of my review article and some of my conclusions. This reply is intended to clear up some of the misunderstandings, and to shed light on an apparent disagreement.
Side Effects and Complications of Fractional Laser Photothermolysis: Experience with 961 Treatments

BACKGROUND A novel 1,550-nm erbium-doped laser (Fraxel, Reliant Technologies Inc.) has been shown to be effective in the treatment of photodamaged skin and scars with minimal postoperative recovery; however, studies evaluating its side effects and complication rates have been limited. PURPOSE The purpose was to determine the frequency and range of side effects and complications associated with fractional photothermolysis treatment. METHODS A retrospective evaluation of 961 successive 1,550-nm erbium-doped laser treatments in patients of various skin phototypes (I–V) was conducted in a single center. Side effects and complications of treatment, including time of onset and duration, were identified and tabulated. Patient demographics and laser parameters were also assessed. RESULTS Seventy-three treatments (7.6%) resulted in development of complications. The most frequent complications were acneiform eruptions (1.87%) and herpes simplex virus outbreaks (1.77%). Side effects and complications were equally distributed across different ages, skin types, body locations, laser parameters, and underlying skin conditions, except for postinflammatory hyperpigmentation, which occurred with increased frequency in patients with darker skin phototypes. CONCLUSIONS Fractional laser skin treatment is associated with a relatively low complication rate. Side effects and complications observed in this study were temporary and did not result in long-term or significantly severe sequelae (e.g., scarring).
Cytoplasmic Localization of β-Catenin is a Marker of Poor Outcome in Breast Cancer Patients

β-catenin is involved in cell adhesion through catenin-cadherin complexes and as a transcriptional regulator in the Wnt signaling pathway. Its deregulation is important in the genesis of a number of human malignancies, particularly colorectal cancer. A range of studies has been undertaken in breast cancer, with contradictory associations reported among β-catenin expression, clinicopathologic variables, and disease outcome. We undertook an immunohistochemical study measuring the levels and subcellular localization of β-catenin in 292 invasive ductal breast cancers with known treatment and outcome. No association with breast cancer–specific death was observed for cytoplasmic or membrane expression alone; however, a continuous score representing both locations (membrane minus cytoplasmic expression: MTC score) was associated with a worse outcome in univariate analysis (P = 0.004), and approached significance in a multivariate analysis model that included lymph node, progesterone receptor (PR), and HER2 status (P = 0.054). Therefore, the MTC score was used for further statistical analyses due to the importance of both the subcellular location and the levels of expression of β-catenin. An association was identified between high cytoplasmic expression (low MTC score), and high tumor grade (P = 0.004), positive Ki67 (P = 0.005), negative estrogen receptor (ER) (P = 0.005), positive HER2 (P = 0.04) status, and an active phosphoinositide 3-kinase pathway (P = 0.005), measured as PIK3CA mutations (P = 0.05) or PTEN loss (P = 0.05). Low cytoplasmic expression (high MTC score) was associated with the luminal A subtype (P = 0.004). In conclusion, a low β-catenin MTC score is associated with an adverse outcome in breast cancer, which may be of mechanistic significance in the disease process. Cancer Epidemiol Biomakers Prev; 19(1); 301–9
Exploring Organizational Sustainability of Industry 4.0 under the Triple Bottom Line: The Case of a Manufacturing Company

There is an increasing interest in sustainability practices for organizations. Organizations act sustainably when they support the three dimensions \of the triple bottom line. Industry 4.0 (I40) promises to afford organizations to act sustainably. However, few empirical pieces of research targeted the impact of I40 on the social, economic, and environmental dimensions of sustainability. Our investigation considered the adoption of I40 in a manufacturing company which we analyzed as a single case study. We describe the level of I40 adoption and the process through which the unit has adopted them. Our case confirms that I40 applications support the triple bottom line through the improvement of productivity and product quality (economic), continuous energy consumption monitoring (environmental), and safer work environment and less intense work-load and job enrichment (social). We contribute to the literature by identifying two trajectories of interaction among the three dimensions of the triple bottom line in the shift from a traditional manufacturing company to a knowledge-intense organization. In the trajectories found, the three dimensions of sustainability influence and reinforce each other.
Pregnancy and contraception in a French cohort of HIV‐infected women

Objective:To describe the impact of HIV diagnosis on contraception, incidence of pregnancy and live-births among HIV-infected women in France. Design:Follow-up of women included in a French cohort of HIV-infected adults (SEROCO). Methods:In 17 hospital-based units and one private practitioners’ network in the Paris area and south-east region of France, 412 HIV-infected women (volunteers) were enrolled from 1988 to 1993, shortly after HIV diagnosis (median, 3 months), and followed for a median of 3 years. The main outcome measures were incidence and outcome of pregnancy, proportions of women sexually active and methods of contraception. Results:The incidence of pregnancy decreased significantly from 20.4 per 100 person-years in the year preceding HIV diagnosis to 7.9 per 100 person-years after HIV diagnosis (P < 0.001), whereas the proportion of pregnancies voluntarily interrupted doubled (63 versus 29%). The proportion of women who were sexually inactive increased from 5% before HIV diagnosis to 20% thereafter. During follow-up, 80% of sexually active women were using contraceptive methods. Conclusions:The study supports an association between the discovery of HIV infection and a decrease in the proportion of women who are sexually active, a decrease in the incidence of pregnancy in general and live-births in particular, and an increase in the proportion of pregnancies voluntarily interrupted. Nevertheless, 24% of the women became pregnant and around 20% of sexually active women were not using any contraception. The high rate of voluntary abortion may indicate that many of these pregnancies were unplanned and could have been prevented.
Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial.

CONTEXT Folate, vitamin B(6), and vitamin B(12) are thought to play an important role in cancer prevention. OBJECTIVE To evaluate the effect of combined folic acid, vitamin B(6), and vitamin B(12) treatment on cancer risk in women at high risk for cardiovascular disease. DESIGN, SETTING, AND PARTICIPANTS In the Women's Antioxidant and Folic Acid Cardiovascular Study, 5442 US female health professionals aged 42 years or older, with preexisting cardiovascular disease or 3 or more coronary risk factors, were randomly assigned to receive either a daily combination of folic acid, vitamin B(6), and vitamin B(12) or a matching placebo. They were treated for 7.3 years from April 1998 through July 31, 2005. INTERVENTION Daily supplementation of a combination of 2.5 mg of folic acid, 50 mg of vitamin B(6), and 1 mg of vitamin B(12) (n = 2721) or placebo (n = 2721). MAIN OUTCOME MEASURES Confirmed newly diagnosed total invasive cancer or breast cancer. RESULTS A total of 379 women developed invasive cancer (187 in the active treatment group and 192 in the placebo group). Compared with placebo, women receiving the active treatment had similar risk of developing total invasive cancer (101.1/10,000 person-years for the active treatment group vs 104.3/10,000 person-years for placebo group; hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.79-1.18; P = .75), breast cancer (37.8/10,000 person-years vs 45.6/10,000 person-years, respectively; HR, 0.83; 95% CI, 0.60-1.14; P = .24), or any cancer death (24.6/10,000 person-years vs 30.1/10,000 person-years, respectively; HR, 0.82; 95% CI, 0.56-1.21; P = .32). CONCLUSION Combined folic acid, vitamin B(6), and vitamin B(12) treatment had no significant effect on overall risk of total invasive cancer or breast cancer among women during the folic acid fortification era. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00000541.
News-based sentiment analysis in real estate: a machine learning approach

ABSTRACT This paper examines the relationship between news-based sentiment, captured through a machine learning approach, and the US securitised and direct commercial real estate markets. Thus, we contribute to the literature on text-based sentiment analysis in real estate by creating and testing various sentiment measures by utilising trained support vector networks. Using a vector autoregressive framework, we find the constructed sentiment indicators to predict the total returns of both markets. The results show a leading relationship of our sentiment, even after controlling for macroeconomic factors and other established sentiment proxies. Furthermore, empirical evidence suggests a shorter response time of the indirect market in relation to the direct one. The findings make a valuable contribution to real estate research and industry participants, as we demonstrate the successful application of a sentiment-creation procedure that enables short and flexible aggregation periods. To the best of our knowledge, this is the first study to apply a machine learning approach to capture textual sentiment relevant to US real estate markets.
Long-term trends in airborne SO2 in an air quality monitoring station in Seoul, Korea, from 1987 to 2013

ABSTRACT Atmospheric concentration of sulfur dioxide (SO2) was intermittently measured at an air quality monitoring (AQM) station in the Yong-san district of Seoul, Korea, between 1987 and 2013. The SO2 level was compared with other important pollutants concurrently measured, including methane (CH4), carbon monoxide (CO), nitric oxide (NO), nitrogen dioxide (NO2), ozone (O3), and particulate matter (PM10). If split into three different periods (period 1, 1987–1988, period 2, 1999–2000, and period 3, 2004–2013), the respective mean [SO2] values (6.57 ± 4.29, 6.30 ± 2.44, and 5.29 ± 0.63 ppb) showed a slight reduction across the entire study period. The concentrations of SO2 are found to be strongly correlated with other pollutants such as CO (r = 0.614, p = 0.02), which tracked reductions in reported emissions due to tighter emissions standards enacted by the South Korean government. There was also a clear seasonal trend in the SO2 level, especially in periods 2 and 3, reflecting the combined effects of domestic heating by coal briquettes and meteorological conditions. Although only a 16% concentration reduction was achieved during the 27-year study duration, this is significant if one considers rapid urbanization, an 83.2% increase in population, and rapid industrialization that took place during that period. Implications: Since 1970, a network of air quality monitoring (AQM) stations has been operated by the Korean Ministry of Environment (KMOE) for routine nationwide monitoring of air pollutant concentrations in urban/suburban areas. To date, the information obtained from these stations has provided a platform for analyzing long-term trends of major pollutant species. In this study, we examined the long-term trends of SO2 levels and relevant environmental parameters monitored continuously in the Yong-san district of Seoul between 1987 and 2013. The data were analyzed over various time scales (i.e., monthly, seasonal, and annual intervals). The results obtained from this study will allow us to assess the effectiveness of abatement strategy and to predict future concentrations trends in association with future abatement strategies and technologies.
Role Models and Women Entrepreneurs: Entrepreneurial Superwoman Has Her Say *

It is suggested that more “role model” women entrepreneurs are needed. However, the gender gap in entrepreneurship remains. This study analyses the narratives of 51 role model women entrepreneurs to explore how they represent women entrepreneurs and entrepreneurship. We found that in accordance with the contemporary pressure for women to succeed and perform personally and professionally, the voice of the (super)woman doing “individualized entrepreneurial femininity” dominates. The role models narratives obscure race, class, and age barriers; reproduce prevailing gender stereotypes; normalize discriminatory workplace treatment and depict entrepreneurship as an appropriate alternative for working mothers. Implications for policy makers are presented.
Values Stability and Change in Adulthood

Recent studies have examined whether values change across time. The present study investigates both rank-order stability and mean-level differences in core values—and whether age and sex moderate stability and change—over 3 years using a national probability sample (from 25 to 75 years; N = 3,962). Value priorities were highly stable, except for Conservation values among women, which peaked in stability at age 50 and decreased afterward. Older adults and women placed greater emphasis on values relating to the welfare of others and preservation of traditional practices and stability (Self-Transcendence and Conservation values). Younger individuals and men tended to more highly value the pursuit of status and power, and independent thought and behavior (Self-Enhancement and Openness to Change). The results are consistent with a life span perspective on values development and indicate values may change slowly throughout life as a reflection of biological and psychological maturation.
Serine phosphorylation by casein kinase II controls endocytic L1 trafficking and axon growth

The cell adhesion molecule L1 plays crucial roles in axon tract development. In vitro, L1 presented as a culture substrate stimulates axon elongation by binding to L1 expressed on the growth cone. In migrating growth cones, L1 is endocytosed via the AP‐2/clathrin‐mediated pathway at the central domain, followed by anterograde vesicular transport and recycling to the plasma membrane of the leading front. It has previously been shown that this endocytic trafficking of L1 is critical for axon elongation (Kamiguchi and Yoshihara [2001] J. Neurosci. 21:9194–9203). Adjacent to the AP‐2 recognition site, the L1 cytoplasmic domain has a cluster of acidic amino acids containing Ser1181 that can be phosphorylated by casein kinase II (CKII; Wong et al. [1996a] J. Neurochem. 66:779–786). In this paper, we demonstrate that Ser1181 phosphorylation by CKII is implicated in both normal endocytic trafficking of L1 and L1‐stimulated axon growth. Whereas L1 is sorted into transferrin‐positive endosomes after endocytosis, pharmacological inhibition of CKII caused some population of L1 to be internalized into transferrin‐negative compartments. Single‐amino‐acid mutations at Ser1181, which either prevent or mimic phosphorylation by CKII, caused similar missorting of internalized L1. Furthermore, dorsal root ganglion neurons that had been treated with a CKII inhibitor or transfected with the L1 mutants showed impaired ability to extend axons on an L1 substrate but not on other control substrates. These results demonstrate the novel role of CKII in L1‐mediated axon elongation and stress the importance of functional linkage between L1 phosphorylation and L1 trafficking in migrating growth cones. © 2007 Wiley‐Liss, Inc.
Shifting communities after typhoon damage on an upper mesophotic reef in Okinawa, Japan

Very few studies have been conducted on the long-term effects of typhoon damage on mesophotic coral reefs. This study investigates the long-term community dynamics of damage from Typhoon 17 (Jelawat) in 2012 on the coral community of the upper mesophotic Ryugu Reef in Okinawa, Japan. A shift from foliose to bushy coral morphologies between December 2012 and August 2015 was documented, especially on the area of the reef that was previously recorded to be poor in scleractinian genera diversity and dominated by foliose corals. Comparatively, an area with higher diversity of scleractinian coral genera was observed to be less affected by typhoon damage with more stable community structure due to less change in dominant coral morphologies. Despite some changes in the composition of dominant genera, the generally high coverage of the mesophotic coral community is facilitating the recovery of Ryugu Reef after typhoon damage.
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia

Significance Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3), encoded by stem cell-specific Wnt (wingless-int) target genes, constitute a crucial negative feedback loop in the Wnt signaling pathway. Rnf43 is mutated in subsets of human cancers of the colon, pancreas, stomach, ovary, and liver, while Znrf3 is mutated in adrenocortical carcinoma and osteoblastoma. Indeed, when both genes are mutated simultaneously in small intestinal stem cells in mice, tumors arise within a few weeks. Treatment of mice carrying RZ−/− intestinal neoplasia with a small molecule Wnt secretion inhibitor strongly inhibited growth, while adjacent normal crypts remained intact. These results establish that paracrine Wnt secretion is an essential driver of RZ−/− tumor growth and imply that a therapeutic window exists for the use of porcupine inhibitors for RZ-mutant cancers. Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related transmembrane E3 ligases, encoded by Wnt target genes, that remove surface Wnt (wingless-int) receptors. The two genes are mutated in various human cancers. Such tumors are predicted to be hypersensitive to, yet still depend on, secreted Wnts. We previously showed that mutation of RZ in the intestine yields rapidly growing adenomas containing LGR5+ (leucine-rich repeat-containing G-protein coupled receptor 5) stem cells and Wnt3-producing Paneth cells. We now show that removal of Paneth cells by Math1 mutation inhibits RZ−/− tumor formation. Similarly, deletion of Wnt3 inhibits tumorigenesis. Treatment of mice carrying RZ−/− intestinal neoplasia with a small molecule Wnt secretion inhibitor (porcupine inhibitor C59) strongly inhibited growth, whereas adjacent normal crypts remained intact. These results establish that paracrine Wnt secretion is an essential driver of RZ−/− tumor growth and imply that a therapeutic window exists for the use of porcupine inhibitors for RZ-mutant cancers.
Live virus immunization after orthotopic liver transplantation

Abstract: Viral infection is a recognized and potentially serious complication in children following solid organ transplantation. The risks of viral infection are particularly important for infants who may not have completed standard childhood immunizations at the time of transplantation and are therefore at risk for otherwise preventable infections. The general practice of withholding live virus immunization from transplant recipients has been questioned and several small studies have looked at MMR and/or Varivax administration in children following transplantation. This retrospective study analyzes the response to primary MMR and varicella immunization in selected pediatric liver transplant recipients in the largest such study to date. Nineteen of 26 children (73%) developed serologic immunity for measles following MMR (although 18 required multiple doses). Similarly, varicella immunization resulted in seroconversion in 20 of 31 children (64.5%; seven required multiple doses). Only minor adverse effects reported in the general population were observed. Live virus immunization with MMR and Varivax was safe and immunogenic in this selected population of liver transplant recipients.
Financial Hazard Map: Financial Vulnerability Predicted by a Random Forests Classification Model

This study develops a systematic framework for assessing a country’s financial vulnerability using a predictive classification model of random forests. We introduce a new indicator that quantifies the potential loss in bank assets and measures a country’s overall vulnerability by aggregating these indicators across the banking sector. We also visualize the degree of vulnerability by creating a Financial Hazard Map that highlights countries and regions with underlying risks in their banking sectors.