Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of Hepatic Glucose Production by SDZ 51641

The new oral hypoglycemic agent SDZ 51641 was evaluated in nondiabetic rats and a rat model of human non-insulin-dependent diabetes mellitus. Diabetes was induced with a single injection of 37.5 mg/kg streptozocin, and the rats exhibited hyperglycemia in the fed state with normal insulin levels. Treatment of nondiabetic animals with 100 mg/kg SDZ 51641 given orally significantly decreased serum glucose and ketone levels within 4 h without affecting insulin levels. Nonesterified fatty acids increased more than twofold during the same period. Its effect on ketone and fatty acid levels suggests that SDZ 51641 acts as an inhibitor of fatty acid oxidation. Diabetic rats treated with SDZ 51641 exhibited a significant acute hypoglycemic response, which was more pronounced after 3 days of treatment. The compound also significantly decreased serum cholesterol and triglyceride levels 27 and 53%, respectively. When endogenous hepatic glucose production was assessed in nondiabetic and diabetic animals via continuous infusion of [3-3H]glucose, we found that hepatic glucose production was elevated 43% in diabetic compared with control animals. When diabetic rats were treated with 100 mg/kg SDZ 51641, hepatic glucose production decreased to normal levels within 6 h. Hyperinsulinemic-euglycemic clamp studies indicated that SDZ 51641 had no effect on insulinstimulated glucose utilization. Measurement of [1-14C]oleate oxidation in isolated hepatocytes demonstrated that SDZ 51641 inhibited long-chain fatty acid oxidation in a concentration-dependent manner. The compound was ineffective at inhibiting longchain fatty acid oxidation in epitrochlearis or soleus muscles. In summary, SDZ 51641 is a new oral hypoglycemic agent that is very effective in decreasing blood glucose levels in nondiabetic and diabetic rats. This is accomplished at least partially by inhibition of hepatic glucose production in vivo, with no effect on peripheral glucose utilization. In addition, the ability of SDZ 51641 to decrease serum ketone, cholesterol, and triglyceride levels suggests that inhibition of hepatic glucose production is linked to inhibition of fatty acid oxidation.
Expression and modification of ARC (apoptosis repressor with a CARD domain) is distinctly regulated by oxidative stress in cancer cells

Apoptosis repressor with a CARD domain (ARC), which has been shown to protect against oxidative stress‐induced apoptosis, was initially found to be highly expressed in terminally differentiated tissues like heart and skeletal muscle. Recently, we and others have found that ARC is also expressed at high levels in multiple cancer tissues and cell lines. Here, we compared the regulation of ARC in response to oxidative stress between cancer cells and other types of cells. Similar to cardiomyocyte cell line H9c2 cells, cancer cells with reduced ARC expression were significantly more sensitive to oxidative stress. However, oxidative stress did not down‐regulate ARC expression in cancer cells as it did in H9c2 cells. We further found that in H9c2 cells oxidative stress regulates ARC protein expression post‐translationally through proteasome‐mediated degradation. In cancer cell line HeLa, the majority of ARC exists in phosphorylated state in the absence of oxidative stress, whereas in H9c2 cells only marginal amount of ARC was phosphorylated under similar conditions. Our data suggest that the high level of ARC protein and the constitutive phosphorylation of ARC in cancer cells may play an important role in the protection of cancer cells against oxidative stress. J. Cell. Biochem. 104: 818–825, 2008. © 2008 Wiley‐Liss, Inc.
[Decreased volume of placental lobular villi vessels in patients with intrahepatic cholestasis of pregnancy].

OBJECTIVE To investigate the stereological changes of placental lobular villi vessels in patients with intrahepatic cholestasis of pregnancy (ICP). METHODS Stereological analysis on vessels volume and cross-areas of placental samples taken from 10 normal and 10 ICP patients at 37-40 week pregnancy were performed. RESULTS Compared with normal pregnancy, the ICP patients had 29% reduction in the volume of placental lobular villi vessels [(287.81 +/- 69.81) mL vs. (203.63 +/- 41.29) mL]; 21% reduction in the cross-areas [(617119.5 +/- 158422.65) microm2 vs. (485087.6 +/- 104707.63) microm]2; but no change in the numbers [(313.40 +/- 137.51) vs. (365.20 +/- 96.73)] of lobular villi vessels (P>0.05). Similarly, significant decreases in the volume [(131.98 +/- 84.68) mL vs. (55.98 +/- 21.08) mL] and cross-areas [(271809.6 +/- 162354.35) microm2 vs. (127576.2 +/- 54897.44) microm2] of placental lobular villi vessels with smooth muscles in the ICP patients were also found (P<0.05). But the volume [(161.48 +/- 75.80) mL vs. (155.91 +/- 30.52) mL] and cross-areas [(342639.6 +/- 145717.51) microm2 vs. (341849.3 +/- 57043.88) microm2] of placental lobular villi vessels without smooth muscle in the ICP patients remained unchanged (P>0.05). The placental lobular villi vascular volume was negatively correlated (r = -0.413) with the maternal plasma level of total bile acid (TBA) (P>0.05), and positively correlated (r=0.302) with the onset week of ICP (P>0.05). But the correlations were not statistically significant. CONCLUSION Patients with ICP have 29% reduction in placental lobular villi vascular volume, which is mainly a result of reduction of lobular villi vessels with smooth muscles. The placental lobular villi vascular volume is possibly negatively correled with maternal plasma level of TBA, and positively correled with the onset week of ICP.
The Effect of Environmental and Social Corporate Governance on the Financial Performance with Special Focus on the Egyptian Private Sector Companies within Egx30

Egyptian private sector companies are face increasing pressure on two fronts-requiring greater transparency and disclosure and the need to apply good Environmental and Social Corporate Governance (ESCG) practices. The main objective of this research paper is to examine the relation between Environmental and Social Corporate Governance practices and financial performance (FP) of Egyptian private sector companies included in the official share index of the Egyptian stock change. EGX 30 index the index includes 30 largest firms where liquidity and action. The EGX 30 is weighted at market value and adjusted by free float. The adjusted market value of the listed company is the number of its shares multiplied by the closing price of that company multiplied by the percentage of shares offered freely. This study provides important evidence on the impact of ESCG performance on Corporate Financial Performance (CFP). “This is particularly important given this sustainability and ESCG performance to identify key business activities of listed companies in Egypt. The study concluded that there is a strong correlation between social governance with its four dimensions (board responsibilities, disclosure, and transparency and investor rights protection) and the financial performance of Egyptian private sector companies within EGX30.
A 0.8 dB NF ESD-protected 9 mW CMOS LNA

The GPS L2 band, centered at 1.2276 GHz, is planned to enhance the capabilities of civil GPS to backup the conventional GPS L1 link. As the L2 receiver is required to detect a low power signal, an LNA with extremely low noise figure is required. In addition, the LNA must exhibit a large gain to suppress noise from the subsequent stages. This ESD-protected CMOS LNA meets these requirements.
Individual Case Analysis of Processing Speed Difficulties in Children With and Without Traumatic Brain Injury

Two studies were conducted to determine the frequency of processing speed difficulties relative to estimates of other problem-solving abilities in children with and without traumatic brain injury (TBI). The two samples consisted of 213 normally functioning school-age children and 65 TBI children and 19 trauma controls. All children were administered the WISC-III/IV Vocabulary, Block Design, and Coding subtests. The frequency of children in each sample having a Coding subtest score of 3 or 4 scale points below the Vocabulary or Block Design score (whichever one was lower) was calculated. Using a 3-point scale difference, the presence of processing speed deficits relative to other cognitive abilities in the school sample was low (5.2%), and was equivalent to that demonstrated by trauma controls (5.3%). However, in the TBI sample, 18 out of 65 TBI patients (27.7%) showed this same pattern. Using a 4-point discrepancy scale, 3.3% of normal children and 16.9% of TBI children showed this pattern. The frequency of this pattern increased with severity of TBI, using two different but related classification systems. These preliminary findings require cross validation in a larger sample before definite conclusions can be reached.
Distinctive Effects of the Epstein-Barr Virus Family of Repeats on Viral Latent Gene Promoter Activity and B-Lymphocyte Transformation

ABSTRACT The Epstein-Barr virus (EBV), a human B-lymphotropic gamma herpesvirus, contains multiple repetitive sequences within its genome. A group of repetitive sequences, known as the family of repeats (FR), contains multiple binding sites for the viral trans-acting protein EBNA-1. The FR sequences are important for viral genome maintenance and for the regulation of the promoter involved in viral latent gene expression. It has been reported that a palindromic sequence with a putative secondary structure exists at the 3′ end of the FR in the genome of the EBV B95-8 strain and that this palindromic sequence has been deleted from the FR of the commonly used EBV miniplasmids. For the first time, we cloned an EBV B95-8 DNA fragment containing the full-length FR, which enabled us to examine the functional difference between full-length and deleted FRs. The full-length FR, like the deleted FR, functioned as a transcriptional enhancer of the viral latent gene promoter, but that transactivation was significantly attenuated in the case of the full-length FR. No significant enhancement of replication was observed when the deleted FR was replaced with the full-length FR in an EBV miniplasmid. By contrast, when the same set of FR sequences were tested in the context of the complete EBV genome, the full-length FR resulted in more-efficient B-cell transformation than the deleted FR. We propose that the presence of the full-length FR contributes to the precise regulation of the viral latent promoter and increases the efficiency of B-cell transformation.
The Genetics of Intraocular Pressure

Abstract Glaucoma is a leading cause of irreversible blindness. Intraocular pressure (IOP) is the only modifiable risk factor for glaucoma, yet there is little known about the molecular events that regulate IOP. Genetic and genomic studies have helped identify genes that influence IOP and could lead to the identification of biological pathways that serve as targets for novel pressure-modifying therapies. Genetic linkage studies resulted in the identification of several genes that cause Mendelian (autosomal dominant or autosomal recessive) forms of high-pressure glaucoma, including MYOC. PITX2, FOXC1, and CYP1B1. Classical twin studies suggest that IOP is a heritable trait. More recently, genome-wide association studies (GWAS) have shown that common genetic variants in the GAS7 and TMCO1 genomic regions are associated with elevated IOP. TMCO1 has also been associated with primary open-angle glaucoma in patients with advanced disease. A further study identifying additional genes contributing to IOP will be necessary to fully define the underlying genetic architecture of IOP.
Contracts versus Trust in Water Allocation : growing & sharing the pie in Northeast Brazil preliminary

We explore the efficiency and equity resulting from allocation of a fixed resource within a bargaining institution, using a modification of the Ultimatum Game with asymmetric productivity and a surplus-sharing step that permits us to explore trust. Sharing allows pie division independent of pie growth. We use generically framed experiments based on water allocation in NE Brazil with 570 participants in Ceará, in Fortaleza (the capitol) or the Jaguaribe (largest agricultural) Valley. These areas are soon to be further connected by a large canal to bring water towards Fortaleza. Our games have 3 steps: [1] proposers request a resource amount; [2] responders accept that split or reject it, yielding a low default payment for all; and [3] if that proposal was accepted, proposers choose whether to send back some of the gains. We consider three institutional designs distinguished by levels of communication. In ‘No Communication’, a benchmark, and in ‘Message’ where the proposer sends a non-binding written message about 3-step sharing conditional upon acceptance, we see evidence of 2-step trust (acceptance of less than the default) that pays off. Yet when that sharing message is a binding ‘Contract’, efficiency and equity rise.
Credit Value-Relevance of Earnings, Other Comprehensive Income, and Comprehensive Income: A Study on IFRS Adoption Stage in Indonesia

This research aims to examine the credit value-relevance of net income, other comprehensive income (OCI) and comprehensive income. This research indirectly examines the impact of IFRS adoption on the usefulness of earnings and OCI information. The credit value-relevance measures the usefulness of accounting information from the creditor perspective, represented by the bond rating agency. In this research, accounting information is said to have credit value-relevance if accounting information affects bond rating. The sample of this research is 495 bond issuer companies listed in Indonesia Stock Exchange period 2011-2016. Hypothesis testing is done by the logit regression test. The results show that net income and comprehensive income have credit-value relevance, whereas OCI has no credit relevance. The results also find an increase in the credit-value relevance of comprehensive income from the beginning adoption of IFRS (2011) to the first implementation of IFRS adoption.
PENGARUHDISIPLIN KERJA DAN KOMUNIKASI TERHADAP KINERJA KARYAWAN DI PT.SEKAR MULIA ABADI MEDAN

PT. Sekar Mulia Abadi is a company engaged in the fruit import distributor which has a subsidiary in Pekan Baru. The problems that occur in PT. Sekar Mulia Abadi were relating to the work discipline and communication. Employees were often absent and arriving late and communication between supervisors and subordinates were less effective that employee's performance declined, characterized by decreased sales target so that the company's goal was not achieved. Based on the brief description, the problem formulated in this study as the followings; how is the effect of labor discipline and communication on employes performance at PT. Sekar Mulia Abadi Medan. The theory used in this research are theories of human resource management related to work discipline, communication and employee performance. The method used in this research is quantitative, this kind of research is quantitative descriptive, and the nature of this research is descriptive explanatory. Data collection was performed by interviews, questionnaires, and documentation study. Data analysis method used is multiple regression analysis. The population in this study were all employees of PT. Sekar Mulia Abadi field totaling 102 respondents, of which 30 respondents were used to test the validity and the remaining, 72 respondents were used as samples. Results of the study showed that the hypothesis r 0248 on a unit o work discipline and 0,461 were units of communication which partially has a significant effect on employee performance and simultaneously there is a significant effect of the two variables by 26.2% on employee performance at PT. Sekar Mulia Abadi Medan and the remaining 73.8% is explained by other variables not examined in this study. The study concluded that the simultaneous and partial discipline of work and communication have a significant effect on the performance of employees at PT. Sekar Mulia Abadi field. Â
Descriptions of vestibular migraine and Menière’s disease in Greek and Chinese antiquity

Background Vestibular migraine and Menière’s disease are two types of episodic vertigo syndromes that were already observed in Greek and Chinese antiquity. Descriptions first appeared in the work of the classical Greek physician Aretaeus of Cappadocia, who lived in the 2nd century AD, and in Huangdi Neijing, a seminal medical source in the Chinese Medical Classics, written between the 2nd century BC and the 2nd century AD. Aim The aim of this paper is to search in Aretaeus’ book De causis et signis acutorum et chronicorum morborum and in Huangdi Neijing for descriptions of vertigo co-occurring with headache or ear symptoms that resemble current classifications of vestibular migraine or Menière’s disease. Results Aretaeus describes a syndrome combining headache, vertigo, visual disturbance, oculomotor phenomena, and nausea that resembles the symptoms of vestibular migraine. In the Chinese book Huangdi Neijing the Yellow Thearch mentions the co-occurrence of episodic dizziness and a ringing noise of the ears that recalls an attack of Menière’s disease. Conclusions The descriptions of these two conditions in Greek and Chinese antiquity are similar to the vertigo syndromes currently classified as vestibular migraine and Menière’s disease. In clinical practice it may be difficult to clearly differentiate between them, and they may also co-occur.
#Tarifazo. Medios tradicionales y fusión de agenda en redes sociales

En este artículo analizamos la relación entre medios tra­dicionales, redes sociales y establecimiento de agenda. El modelo de fusión de agendas es consistente con la conformación de burbujas de información, aunque no logra explicar cómo se configura la agenda cuando los usuarios pueden activamente publicar y propagar con­tenidos que les interesan. Nuestro modelo indaga sobre la decisión de los usuarios de promover contenidos con los cuales tienen afinidad cognitiva, en base a la red del #Tarifazo argentino. Medimos la propensión de los usua­rios virtuales a difundir contenidos consistentes con sus creencias políticas, y enlaces a medios tradicionales y no tradicionales, y el tiempo que demoraron en retuitear un mensaje (latencia) en función de los links a medios tra­dicionales incluidos en dichos posteos. Los hallazgos al­canzados indican que los mensajes se propagan con dis­tinta velocidad en la red, dependiendo de la congruencia o disonancia cognitiva existente entre usuarios y de estos para con los mensajes publicados. Concluimos que las comunidades de usuarios construyen agendas colecti­vas y limitan, de esta forma, la capacidad de los medios masivos de establecer la agenda pública de manera gene­ralizada y homogénea.
Wireless Communication: A Conceptual Model of IoT Services Success for Government Agencies

The Internet-of-Things (IoT) is a wireless technology that offers opportunities for Government-Agencies (GA) to improve services to citizens. However, the challenge is to ensure that the IoT is fully utilized as the real value of using IoT services comes from the establishments of services through effective utilization of technologies. This paper aims to develop a conceptual model for successful implementation of IoT services in GA which is one of the least essential studied aspects of utilization of Digital-Government services. This study proposes a new integrated success model that combines the dimensions of Technology-Readiness-Index (TRI) 2.0 with other success factors – service quality, information quality, system quality, user satisfaction, use (from DeLone&McLean Information-System-Success-Model), perceived usefulness (from Technology-Acceptance-Model), and trust construct to understand the determinants of IoT services success model in GA from the perspective of government officers. Interviews with Government-IoT experts are conducted to define and delineate the research problem. The proposed model could bring a better perspective of the critical factors that contribute to the success of IoT services implementation process particularly in GA as well as providing a groundwork for further empirical testing. Moreover, it will suggest an appropriate implementation mechanism to help GA increase the use of IoT services.
Detection of Mutant K‐ras in Dissected Paraaortic Lymph Nodes of Patients with Pancreatic Adenocarcinoma

In this study, we attempted to detect K-ras point mutations by means of two-stage polymerase chain reaction/ restriction fragment length polymorphism (PCR/RFLP) to diagnose micrometastases in paraaortic lymph nodes of patients with pancreatic adenocarcinoma. Main carcinoma tissues and corresponding lymph nodes in the paraaortic region were obtained from 15 patients who underwent extended radical surgery including the wide dissection of lymph nodes and who were diagnosed as lymph node negative by routine histological examination. DNA was extracted from the tissue specimens, and PCR/RFLP analysis was used to detect K-ras oncogene mutations at codon 12. Thirteen of the primary tumors were found to have K-ras mutations. In eight of the 13 cases, 42 of the 101 lymph nodes showed K-ras point mutations in the paraaortic lymph nodes. These results suggested that PCR/ RFLP analysis is potentially highly sensitive for the detection of micrometastases in lymph nodes and that it may be useful in reaching an accurate assessment of the lymphatic dissemination of pancreatic adenocarcinoma at the molecular level.
Lean Philosophy: A step towards improving the management of hotel supply chain

Effective hotel supply chain management has burgeoned as a potentially valuable means for achieving competitive advantage and improving organizational performance. Competition between hotels has recently expanded to include competition between supply chains. Major businesses around the world have realized the value that lean management philosophy can bring to their supply chains. Lean is a systematic approach that is presently argued to be adopted to optimize the entire supply chain management by eliminating wasteful activities (time, effort and materials), increasing product flow efficiency, reducing inventories, and enhancing customer fulfillment and satisfaction. The aim of the current study is two-fold. Firstly, it aims to assess the current level of awareness about lean management within the hotel sector in Egypt, as a point of reference to evaluate the readiness of this sector to implement the lean concept in the management of their supply chains. Secondly, it further attempts to propose a framework to facilitate the implementation of lean in the management of hotel supply chain. A quantitative methodological approach of a questionnaire has been conducted with senior managers in five-star and four-star hotels in Egypt. Findings indicated that hotels in Egypt are somewhat aware of the terms like, for example, lean management, lean thinking, or lean principles, though more emphasis is needed on how to effectively implement lean tools in the management of hotel supply chains. Lean awareness status differed between five-star and four-star sub-segments. Overall, the results indicated that the hotel sector in Egypt has an adequate level of readiness to implement lean supply chain management (LSCM). It was shown that hotels already have in place certain practices that support this philosophy. Finally, a four-phase framework for effective LSCM implementation has been proposed.