Miracle-dz/UniFAR-FTUs huggingface dataset:
An Experimental Evaluation of Point-of-interest Recommendation in Location-based Social Networks

Point-of-interest (POI) recommendation is an important service to Location-Based Social Networks (LBSNs) that can benefit both users and businesses. In recent years, a number of POI recommender systems have been proposed, but there is still a lack of systematical comparison thereof. In this paper, we provide an all-around evaluation of 12 state-of-the-art POI recommendation models. From the evaluation, we obtain several important findings, based on which we can better understand and utilize POI recommendation models in various scenarios. We anticipate this work to provide readers with an overall picture of the cutting-edge research on POI recommendation.
Web page prediction from metasearch results

Purpose – This study aims to present a new web page recommendation system that can help users to reduce navigational time on the internet.Design/methodology/approach – The proposed design is based on the primacy effect of browsing behavior, that users prefer top ranking items in search results. This approach is intuitive and requires no training data at all.Findings – A user study showed that users are more satisfied with the proposed search methods than with general search engines using hot keywords. Moreover, two performance measures confirmed that the proposed search methods out‐perform other metasearch and search engines.Research limitations/implications – The research has limitations and future work is planned along several directions. First, the search methods implemented are primarily based on the keyword match between the contents of web pages and the user query items. Using the semantic web to recommend concepts and items relevant to the user query might be very helpful in finding the exact conte.
Etanercept in the treatment of refractory SAPHO syndrome.

OBJECTIVE To explore the application and efficacy of TNF-α inhibitors in the treatment of SAPHO syndrome. METHODS Two cases of refractory SAPHO syndrome were successfully treated with etanercept. And pain scores, laboratory parameters and functional index were used to judge the efficacies. Literature was also systemically reviewed. RESULTS Both patients achieved marked clinical remission. There was no obvious toxic or adverse response. CONCLUSION Etanercept has rapid and definite efficacies in the treatment of patients with refractory SAPHO syndrome.
Acutely Transforming Avian Leukosis Virus Subgroup J Strain 966: Defective Genome Encodes a 72-Kilodalton Gag-Myc Fusion Protein

ABSTRACT Avian leukosis virus subgroup J (ALV-J), the most recent member of the avian retroviruses, is predominantly associated with myeloid leukosis in meat-type chickens. We have previously demonstrated that the acutely transforming virus strain 966, isolated from an ALV-J-induced tumor, transformed peripheral blood monocyte and bone marrow cells in vitro and induced rapid-onset tumors, suggesting transduction of oncogenes (L. N. Payne, A. M. Gillespie, and K. Howes, Avian Dis. 37:438–450, 1993). In order to understand the molecular basis for the rapid transformation and tumor induction, we have determined the complete genomic structure of the provirus of the 966 strain. The sequence of the 966 provirus clone revealed that its genome is closely related to that of HPRS-103 but is defective, with the entire pol and parts of the gag andenv genes replaced by a 1,491-bp sequence representing exons 2 and 3 of the c-myc gene. LSTC-IAH30, a stable cell line derived from turkey monocyte cultures transformed by the 966 strain of ALV-J, expressed a 72-kDa Gag-Myc fusion protein. The identification of the myc gene in 966 virus as well as in several other ALV-J-induced tumors suggested that the induction of myeloid tumors by this new subgroup of ALV occurs through mechanisms involving the activation of the c-myc oncogene.
A prominent role for the IL1 pathway and IL15 in susceptibility to chronic cavitary pulmonary aspergillosis.

Chronic cavitary pulmonary aspergillosis (CCPA) is a progressive lung condition with a 10-30% annual mortality. Although overtly immunocompetent, some immunogenetic defect in patients is likely. To investigate a possible immunogenetic defect in CCPA, we analysed biologically plausible candidate genes in 112 CCPA patients and 279 healthy controls in a genetic association study of genes involved in the post-recognition immune response to Aspergillus fumigatus. We also compared gene expression in monocyte-derived macrophages from subjects with and without disease, both at baseline and during stimulation with A. fumigatus. Compared with macrophages from healthy subjects, CCPA macrophages showed unrestrained rises in IL1A, IL1B, IL6, IRAK2 and TRAF6 throughout the experiment, and a lack of expression of TGFB1 at 9 h. Single nucleotide polymorphisms (SNPs) associated with CCPA were found in IL1B (n = 2), IL1RN and IL15 (n = 3). Uncontrolled expression of IL1 and IL6 and continuing high levels of these cytokines may result in continuing cellular influx and pro-inflammatory responses, inhibiting disease resolution and contributing to disease progression in CCPA. The association of SNPs in IL1B, IL1RN and IL15 with CCPA supports a role for the IL1 pathway, as well as implicating the IL15 gene, in susceptibility to CCPA.
Analytical Solution of Advective Mixing in a Conduit

The permeable conduit wall in a karst aquifer allows for water and solute to be exchanged between conduits and the limestone matrix. Contaminant sequestered in the limestone matrix is flushed into conduits following flood events. The contaminant released from the permeable wall will then mix with conduit water and will be transported downgradient in the conduit. A one‐dimensional advection‐dispersion equation is presented to describe this mixing‐transport incorporating water flow and solute flux through the conduit wall. An analytical solution ignoring conduit dispersion is derived using the method of characteristics. Scale analysis is performed to provide a general guideline to estimate when conduit dispersion can be neglected. The solution also can be used to compute the distribution of solute in the matrix before flushing.
Business strategies and manufacturing decisions: An empirical examination of linkages

Purpose – This paper seeks to investigate whether linkages, proposed by previous researchers, among business strategies and structural and infrastructural investment decisions of manufacturing are empirically supported.Design/methodology/approach – A sample of 101 US manufacturing firms is classified into three groups based on their predominant business strategies. The classification is validated using analysis of variance (ANOVA) tests on the taxons and on the environment in which the firms operate. ANOVA tests on manufacturing investment decisions are then used to address the central question of the paper – whether the three business strategy groups differ in their emphasis on structural and infrastructural areas of manufacturing.Findings – The three business strategy‐based groups of firms, labeled broad‐based competitors, differentiators, and price leaders, differ in their emphasis on several of the structural and infrastructural areas of manufacturing, thus supporting the contention of linkages among .
Impact of stenting technique and bifurcation anatomy on long-term outcomes of PCI for distal unprotected left main coronary disease.

OBJECTIVES We aimed to assess the associations of stenting strategy and bifurcation anatomy with outcomes of percutaneous coronary intervention (PCI) for distal unprotected left main (ULM) coronary disease. BACKGROUND There are limited and conflicting data regarding long-term outcomes associated with stenting strategies for PCI of distal ULM coronary disease. METHODS Patients undergoing non-emergent PCI for distal ULM coronary disease comprised the study cohort. Baseline characteristics and outcomes including cardiac death, cardiac death or myocardial infarction (MI), and overall major adverse cardiac events (MACEs) were compared for patients undergoing single-vessel stenting (SVS) versus bifurcation stenting (BS). RESULTS Seventy patients underwent treatment of distal ULM coronary disease with PCI. Drug-eluting stents (DESs) were used in 96% and 32 (46%) had BS. Patients undergoing SVS vs BS had more severe disease involving the left circumflex artery. Patients with BS were more likely to experience cardiac death and MI (hazard ratio [HR] 3.5; 95% confidence interval [CI], 1.1-11.1; P=.04) or combined MACE (HR, 4.2; 95% CI, 1.8-10.2; P=.001). After adjusting for angiographic characteristics of the bifurcation in Cox proportional hazards models, BS remained a significant predictor of MACE. CONCLUSIONS In this unselected series of patients undergoing PCI for distal left main disease, a single-vessel stenting strategy was associated with superior long-term outcomes after accounting for angiographic characteristics of the bifurcation. Future studies need to take into account additional factors to clarify the ideal treatment strategy for distal left main disease.
The origin and migration of primordial germ cells in the mouse.

Primordial germ cells (PGCs) are the founders of the gametes. They migrate from their origin to combine with the somatic component of the gonad. Progenitors in mice have been recognized in the proximal epiblast. When and how these cells are allocated to the germ line has not been elucidated fully. Numerous growth factors have been described which affect PGC survival, proliferation and directional control during their migration. The extracellular matrix also may play a role in PGC migration, particularly fibronectin and laminin. Once they have arrived at the gonad, PGCs aggregate with one another. The molecules governing this PGC-PGC interaction have yet to be identified.
An Empirical Model of Drug Detailing: Dynamic Competition and Policy Implications

The practice of detailing in the marketing of prescription drugs is undergoing significant changes. For instance, in September 2013, the Physician Payment Sunshine Act went into full effect. The accompanying transparency requirements have prompted physician practices and hospitals to severely restrict pharmaceutical sales representatives’ direct access to their physicians. Despite all the attention in the popular press, scant scholarly research has investigated how these restrictions on physician access impact physician prescription behavior and competitive detailing to physicians. To analyze the impact of these restrictions, we develop a structural model of how pharmaceutical firms compete dynamically to schedule detailing to physicians. Detailing activities are known to have significant carryover effects that are captured in a first-stage model of physicians’ demand for prescription drugs. We also specify detailing policy functions that describe each firm’s observed detailing actions. In a second stage, we estimate a model that describes costs of detailing, assuming that the observed detailing levels are consistent with a Markov perfect Nash equilibrium. The estimated structural model is used to examine the implications of restrictions on the amount of detailing via counterfactual simulations. We find that restriction policies would increase the market share of a nondrug-treatment-only option but impact firms asymmetrically; firms that are strong in detailing and/or rely more on detailing would be hurt more. Unexpectedly, a policy that imposes a ceiling on detailing frequency could significantly reduce detailing of all firms in the market, including those firms with average detailing levels below the ceiling, and effectively would soften competition between firms and enhance their profits. This paper was accepted by J. Miguel Villas-Boas, marketing .
Chondromyxoid fibroma (fibromyxoid chondroma) of bone. A clinico-pathological study of thirty-two cases.

1. A series of thirty-two cases of chondromyxoid fibroma is reported. 2. The clinical, radiographic and pathological features are described. 3. The rarity of the tumour and of malignant change is stressed. 4. Excision or block resection is preferred to curettage as a method of treatment, because of the liability to recurrence after curettage. 5. It is suggested that the designation "fibromyxoid chondroma" is more appropriate than the usual designation "chondromyxoid fibroma".
Recent increases in the notification of Barmah Forest virus infections in New South Wales.

Infection due to Barmah Forest virus (BFV) is an emerging problem in Australia, with increased numbers of cases being reported. BFV is a mosquito-borne arbovirus from the Togaviridae family. The virus was first isolated in 1974 from the Barmah State Forest in the Murray Valley region of the Victoria–New South Wales border, and was first shown to be pathogenic to humans in 1988. Symptoms of acute human infection may include rash, arthralgia, myalgia, lethargy and fever, and are similar to symptoms caused by Ross River virus infection. However, rash is more common and florid, and joint disease is less severe, in BFV disease than in Ross River virus disease. In a study of BFV cases on the mid-north coast of New South Wales, over half of all cases reported time off work and an illness that lasted more than 6 months. BFV disease is therefore associated with a significant burden of illness and is of public health concern. This article describes trends in the notification rates for BFV disease in New South Wales since it was made notifiable in 1991.
Review of 65 cases of infective endocarditis in Dunedin Public Hospital.

BACKGROUND AND AIM Infective endocarditis remains a challenging disease to manage. The objective of this study was to evaluate the management of patients diagnosed with infective endocarditis presenting to a regional hospital. METHODS During the years 1997 to 2002, 65 episodes of bacterial endocarditis in 62 patients (20 female, 42 male; age range from 7-89 yrs, median 68 yrs) classified as definite or possible according to the Duke criteria were reviewed retrospectively. The demographic data, predisposing factors, echocardiographic findings, culture results, complications and mortality were recorded and analysed. RESULTS Forty-five episodes (69%) were definite endocarditis and 20 episodes (31%) were possible endocarditis. All cases had undergone transthoracic or transoesophageal echocardiograms with vegetations found in 59 (91%) episodes. There were 49 cases of native valve endocarditis, 21 (34%) of whom had either congenital or acquired valvular disease. Fifteen cases (23%) were prosthetic valve endocarditis. One case was automated implantable cardioverter defibrillator leads endocarditis. Preceding dental or surgical manipulation was observed in 7 cases (11%). Aortic valve (38/59, 64%) was the most common valve involved followed by mitral valve (21/59, 36%). Staphylococcus aureus accounted for 20 episodes (31%), Streptococcus viridans for 16 episodes (25%), Enterococcus faecalis for 5 episodes (8%), other organisms for 9 episodes (14%), and culture negative endocarditis (CNE) for 15 episodes (23%). The majority of the cases had single valve involvement (50/59, 85%); only 9 cases (15%) were double valve endocarditis. Ten cases (15%) needed urgent valve replacement. The overall in-hospital mortality rate was 20% (13/65), and at 6 months was 31% (20/65). Higher 6-month mortality was seen in patients with Staphylococcus aureus endocarditis or CNE. CONCLUSIONS Despite major advances in diagnostic technology, improvement in antimicrobial selection and monitoring, and progress in surgical techniques, the morbidity and mortality of bacterial endocarditis remain high.
Comparison of Different Collagenases in Isolation of Adult Pig Islets

Pig islets m a y be considered as an alternative t issue source for islet transplantat ion in h u m a n s because o f the successful experience o f using pig insulin for the treatment o f d iabetes mel l i tus (1) . T h e establ ished m e t h o d for the i so lat ion o f funct ioning islets f rom large animals with the highest purity in an e c o n o m i c way is essential for clinical islet transplantation. In this s tudy, w e examined different types o f co l lagenases t o isolate adult pig islets, and compared the number and funct ion o f the harvested islets.
Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials

OBJECTIVE To determine the cardiovascular and coronary risk thresholds at which aspirin for primary prevention of coronary heart disease is safe and worthwhile. DESIGN Meta-analysis of four randomised controlled trials of aspirin for primary prevention. The benefit and harm from aspirin treatment were examined to determine: (1) the cardiovascular and coronary risk threshold at which benefit in prevention of myocardial infarction exceeds harm from significant bleeding; and (2) the absolute benefit expressed as number needed to treat (NNT) for aspirin net of cerebral haemorrhage and other bleeding complications at different levels of coronary risk. MAIN OUTCOME MEASURES Benefit from aspirin, expressed as reduction in cardiovascular events, myocardial infarctions, strokes, and total mortality; harm caused by aspirin in relation to significant bleeds and major haemorrhages. RESULTS Aspirin for primary prevention significantly reduced all cardiovascular events by 15% (95% confidence interval (CI) 6% to 22%) and myocardial infarctions by 30% (95% CI 21% to 38%), and non-significantly reduced all deaths by 6% (95% CI −4% to 15%). Aspirin non-significantly increased strokes by 6% (95% CI −24% to 9%) and significantly increased bleeding complications by 69% (95% CI 38% to 107%). The risk of major bleeding balanced the reduction in cardiovascular events when cardiovascular event risk was 0.22%/year. The upper 95% CI for this estimate suggests that harm from aspirin is unlikely to outweigh benefit provided the cardiovascular event risk is 0.8%/year, equivalent to a coronary risk of 0.6%/year. At coronary event risk 1.5%/year, the five year NNT was 44 to prevent a myocardial infarction, and 77 to prevent a myocardial infarction net of any important bleeding complication. At coronary event risk 1%/year the NNT was 67 to prevent a myocardial infarction, and 182 to prevent a myocardial infarction net of important bleeding. CONCLUSIONS Aspirin treatment for primary prevention is safe and worthwhile at coronary event risk ⩾ 1.5%/year; safe but of limited value at coronary risk 1%/year; and unsafe at coronary event risk 0.5%/year. Advice on aspirin for primary prevention requires formal accurate estimation of absolute coronary event risk.
Rabbit heart nodal tissue, sinuatrial ring bundle and atrioventricular connexions indentified as a neuromuscular system.

The normal cardiac impulse is generated in pacemaker cells at the centre of the sinuatrial (S-A) node. It spreads radially within the node, excites the crista terminalis over a broad front and thereafter accelerates in two directions along this structure. In one direction, it passes down along the crista, round the openings of the inferior vena cava and coronary sinus to the atrioventricular (A-V) ring and the A-V node. In the other direction, it spreads to the left in front of the superior vena cava to where the crista terminalis meets the interatrial septum and interatrial (Bachmann's) bundle. From this site, the impulse continues into the interatrial septum and to the left atrium (Bachmann, 1916; Paes de Carvalho, De Mello & Hoffman, 1959; Horibe, 1961; Sano & Yamagishi, 1965; Wagner, Lazzara, Weiss & Hoffman, 1966; Spach et al. 1971). Although these pathways seem well established functionally it has been difficult to demonstrate them morphologically, and there is no identity between the descriptions either of the course of the pathways or of the cytological characteristics of the conducting cells (Paes de Carvalho et al. 1959; Robb & Petri, 1961; Truex & Smythe, 1965; James, 1967; Takayasu, 1967; Merideth & Titus, 1968; Emberson & Challice, 1970). In the pig heart we have shown that the ChE-positive reaction of nerves in the nodal tissue and conducting system of the ventricles may be utilized to identify the specialized tissues (Bojsen-Moller & Tranum-Jensen, 1971 a, b). In the present work the method was used to study the topography of the atrial tracts and atrioventricular connexions in whole mounts of the rabbit heart. Information from this mapping was used to secure a precise excision and orientation of tissue blocks for histological examination of the contained cells.
Emotional memories are resilient to time: Evidence from the parietal ERP old/new effect

Emotional memories can be extremely robust and long‐lasting and can contribute to the development of anxiety disorders. Despite tremendous work on neural responses underlying the memory formation of emotional events, less is known about long‐term retention. In the present study, behavioral and electrophysiological measures were used to investigate long‐term recognition memory for emotional (unpleasant and pleasant) and neutral pictures after two retention intervals (1 week vs. 1 year) in 21 male subjects. The results show enhanced recognition performance for emotional relative to neutral pictures for both test delays. On the neural side, the retrieval of emotional pictures compared to neutral pictures was accompanied after 1 week by an enhanced old/new effect (500–800 ms), originating in the parietal cortex. After 1‐year retention delay, only unpleasant but not pleasant pictures were different from neutral pictures in the recollection‐sensitive ERP component. Analysis of the subjective awareness (confidence ratings) during recognition indicated that behavioral and electrocortical response patterns were exclusively driven by high confidence responses, an indication for recollection‐based recognition. These results suggest that high arousing emotional memories were highly consistent over time relative to neutral memories. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Comparison of immunoblotting with other serological methods and virus isolation for the early detection of primary cytomegalovirus infection in allograft recipients

Sequential specimens from nine allograft recipients were examined by using a variety of methods to detect primary cytomegalovirus (CMV) infection as rapidly as possible posttransplantation. Sera were examined for immunoglobulin G (IgG) and IgM antibodies by immunoblotting, enzyme immunoassay, and immunofluorescence and also by complement fixation, latex agglutination, and an immunofluorescence test for antibody to CMV early antigen. Urine and occasionally blood, tissue, and other specimens were centrifuged onto cell cultures to enhance CMV infectivity. Eight of the nine patients showed laboratory evidence of primary CMV infection, and CMV was isolated from seven of the eight: in no case was virus isolated before seroconversion had become evident. However, serological tests differed in their abilities to detect antibody response to CMV infection in different patients; while immunoblotting, latex agglutination, and enzyme immunoassay for IgG antibodies generally detected seroconversion before complement fixation, this was not invariably the case. At present, optimal laboratory detection of CMV infections in these patients can be achieved only by a combination of serological methods and virus isolation.