Miracle-dz/UniFAR-FTUs huggingface dataset:
Anesthesia for endovascular treatment of acute ischemic stroke

The initial treatment of patients with acute ischemic stroke (AIS) focuses on rapid recanalization, which often includes the use of endovascular therapies. Endovascular treatment depends upon micronavigation of catheters and devices into the cerebral vasculature, which is easier and safer with a motionless patient. Unfortunately, many stroke patients are unable to communicate and sufficiently cooperate with the procedure. Thus, general anesthesia (GA) with endotracheal intubation provides an attractive means of keeping the patient comfortable and motionless during a procedure that could otherwise be lengthy and uncomfortable. However, several recent retrospective studies have shown an association between GA and poorer outcomes in comparison with conscious sedation for endovascular treatment of AIS, though prospective studies are lacking. The underlying reasons why GA might produce a worse outcome are unknown but may include hemodynamic instability and hypotension, delays in treatment, prolonged intubation with or without neuromuscular blockade, or even neurotoxicity of the anesthetic agent itself. Currently, the choice between GA and conscious sedation should be tailored to the individual patient, on the basis of neurologic deficits, airway and hemodynamic status, and treatment plan. The use of institutional treatment protocols may best support efficient and effective care for AIS patients undergoing endovascular therapy. Important components of such protocols would include parameters to choose anesthetic modality, timeliness of induction, blood pressure goals, minimization of neuromuscular blockade, and planned extubation at the end of the procedure.
Comparison of the Monocular Occlusion and a Direct Method for Objective Measurement of Fixation Disparity

Purpose. Previous studies have measured objective fixation disparity using a monocular occlusion method, by which the monocular components of misalignment are revealed by measuring the shift in the position of the fixating eye after occlusion of the other eye. Methods. We assessed the use of the monocular occlusion method by comparing it to direct measurements of binocular vergence. Results. The direct method required precise calibration, but was found to be reliable. Several problems were discovered with the monocular occlusion method: (1) when using a central fusion stimulus, fixation was difficult to control accurately enough to measure the small monocular shifts in eye position expected at lower vergence demands; (2) with a peripheral fusion target, objective fixation disparity could not be measured directly; and (3) upon occlusion, a variable saccade occurred in the fixating eye. Conclusion. Objective measurement of fixation disparity with the direct method is quicker and more reliable than with the monocular occlusion method.
The 3‐D Velocity Models and Seismicity Highlight Forearc Deformation Due to Subducting Features (Central Vanuatu)

The central Vanuatu forearc is characterized by a reduced convergence rate at the trench, significant uplift of the overriding plate, and the presence of large forearc islands. Volcanic activity and intermediate‐depth seismicity behind the forearc are among the highest on Earth. These features are presumed to be associated with the subduction of a large seamount chain and an immersed ridge. We used a catalog of P and S arrivals from a local seismological network to construct the first 3‐D velocity model of the region and to relocate earthquakes beneath the forearc. The 3‐D model reveals a highly heterogeneous velocity distribution in the first 40 km beneath the surface. Trench‐parallel low P and S velocity zones in the upper tens of kilometers beneath the western edges of the two largest forearc islands correlate to the major features entering into subduction and suggest highly fractured and probably water‐infiltrated features. Trench‐parallel high‐velocity zones at 5–15‐km depth, further to the east, may be part of a continuous consolidated rock structure that acts as a backstop. Thick overriding plate crust (29 ± 3 km) in the forearc is consistent with the presence of continental remnants. The earthquake distribution is generally heterogeneous, suggesting a complex fault structure and variable stress. Earthquakes are, however, well aligned at the plate interface in between the subducting features, where they constrain the angle of subduction to be 15° on average, down to 10–15‐km depth.
Pemberian Scaffolding Berdasarkan Kesalahan Berpikir Siswa Dalam Memecahkan Masalah Matematika

This research was aimed to elaborate on the form of scaffolding given by learners on algebra problem-solving. The approach used is descriptive qualitative. The study conducted in a junior high school in Malang Regency with 25 students and only two students were selected as research subjects to be given scaffolding level 2. Data collection method begins by requiring learners to solve algebra and next identify the pattern of mistakes or mistakes. Learners who have wrong answers, used as research samples. The results prove the form of scaffolding given the subject. If the subject experiences an error in understanding the problem, the scaffolding is given asking the subject to re-read the problem properly and carefully and give direction questions. However, if the subject has difficulty in making the planning of the settlement, the scaffolding given is giving the subject the opportunity to rearrange the design of the right answer. If the subject experiences an error in carrying out the planning, the scaffolding given is asking the subject to pay attention to the mathematical concept and to be careful in operating algebra.
Colonization by Streptococcus penumoniae in human immunodeficiency virus-infected children.

OBJECTIVE Children with HIV infection are particularly susceptible to invasive pneumococcal disease, yet the effect of HIV infection and its medical management on colonization and resistance to antibiotics are poorly described. To provide a basis for medical practice, we determined the prevalence of nasopharyngeal colonization and antibiotic resistance of Streptococcus pneumoniae in children with HIV infection. METHODS Cross-sectional prevalence sample of children attending the pediatric HIV and pulmonary clinics to examine nasopharyngeal colonization with S. pneumoniae and antibiotic resistance to beta-lactams and trimethoprim-sulfamethoxazole (T/S). Subjects were matched by age and date of clinic visit. RESULTS The colonization rate with S. pneumoniae of HIV-infected and -indeterminate children was equal to that of controls (20% vs. 19%). HIV infection, CDC staging or receipt of oral antibiotic therapy did not affect colonization. Isolates from HIV-infected and -indeterminate children were less likely to be penicillin-resistant than those from controls (18% vs. 50%). There was no difference in pneumococcal resistance to T/S among isolates from subjects and controls, despite 72% T/S use in the HIV clinic. CONCLUSION Colonization with S. pneumoniae in HIV disease is no different from that of comparable children. The high incidence of pneumococcal disease and prophylaxis with T/S are not related to nasopharyngeal colonization. Antibiotic prophylaxis of HIV-infected children does not necessarily lead to increased resistance of S. pneumoniae.
Does allicin combined with vitamin B-complex have superior potentials than alpha-tocopherol alone in ameliorating lead acetate-induced Purkinje cell alterations in rats? An immunohistochemical and ultrastructural study.

BACKGROUND The current article aims to explore the protective potentials of α-tocopherol alone and the combination of allicin and vitamin B-complex against lead-acetate neurotoxicity on the cerebellar cortex. MATERIALS AND METHODS Forty rats were divided into four groups (n = 10). Group 1 was the control group; Group 2 received 10 mg/kg body weight (BW) of lead acetate; Group 3 was exposed to 10 mg/kg BW of lead acetate plus a combination of allicin (100 mg/kg BW) and vitamin B-complex (40 mg/kg BW); Group 4 was administered lead acetate (10 mg/kg BW) and α-tocopherol (100 mg/kg BW). The animals received the treatment for 60 days by oral gavage. All the groups were studied ultrastructurally and immunohistochemically with glial fibrillary acidic protein (GFAP). RESULTS The affected groups revealed shrunken and degenerated Purkinje cells with irregular nuclei. The cytoplasm comprised several lysosomes, unhealthy mitochondria, and dilated Golgi saccules. The myelinated nerve fibres demonstrated breaking of the myelin sheaths, apparent vacuoles, and broad axonal spaces. Immunohistochemically, there was a tremendous surge in GFAP-positive astrocytes in the lead acetate-treated group. These histological and ultrastructural variations were ameliorated by the administration of a-tocopherol and the combination of allicin and vitamin B complex. Moreover, an apparent decrease in the number of GFAP-positive astrocytes was obvious in the protected groups. CONCLUSIONS Although both a-tocopherol and the combination of allicin and vitamin B-complex can be used as possible adjuvant therapies to ameliorate nervous system ailments attributable to lead acetate, α-tocopherol showed more protective potential.
Melatonin prevents pancreatic β‐cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress

Prolonged hyperglycemia results in pancreatic β‐cell dysfunction and apoptosis, referred to as glucotoxicity. Although both oxidative and endoplasmic reticulum (ER) stresses have been implicated as major causative mechanisms of β‐cell glucotoxicity, the reciprocal importance between the two remains to be elucidated. The aim of this study was to evaluate the differential effect of oxidative stress and ER stress on β‐cell glucotoxicity, by employing melatonin which has free radical‐scavenging and antioxidant properties. As expected, in β‐cells exposed to prolonged high glucose levels, cell viability and glucose‐stimulated insulin secretion (GSIS) were significantly impaired. Melatonin treatment markedly attenuated cellular apoptosis by scavenging reactive oxygen species via its plasmalemmal receptor‐independent increase in antioxidant enzyme activity. However, treatments with antioxidants alone were insufficient to recover the impaired GSIS. Interestingly, 4‐phenylbutyric acid (4‐PBA), a chemical chaperone that attenuate ER stress by stabilizing protein structure, alleviated the impaired GSIS, but not apoptosis, suggesting that glucotoxicity induces oxidative and ER stress independently. We found that cotreatment of glucotoxic β‐cells with melatonin and 4‐PBA dramatically improved both their survival and insulin secretion. Taken together, these results suggest that ER stress may be the more critical mechanism for prolonged high‐glucose‐induced GSIS impairment, whereas oxidative stress appears to be more critical for the impaired β‐cell viability. Therefore, combinatorial therapy of melatonin with an ER stress modifier may help recover pancreatic β‐cells under glucotoxic conditions in type 2 diabetes.
Joint angles of isocomfort for female subjects based on the psychophysical scaling of static standing postures

This study investigated the joint angles of isocomfort (JAIs) for females based on the psychophysical scalings for static standing postures held for 60 s, which were obtained in a laboratory experiment. The subjects were instructed to rate their comfort levels for varyious joint postures by using the free modulus method of magnitude estimation. The comfort scores for the joint postures and the related verbal comfort categories were subjected to regression analysis in order to obtain the JAIs corresponding to verbal categories. The results showed that the JAIs were significantly different depending upon the joints and joint postures investigated (p < 0.01), and that the JAIs for female subjects were significantly different than those for males (p < 0.01) which had been obtained in an earlier study (Kee and Karwowski, 2001). Compared to the corresponding range of joint motion values, the JAIs for hip postures were the smallest of all joint postures dealt with in this study, while those for the neck were the largest of all postures, which means that hip postures are more stressful than any other joint posture. Based on this study, it is recommended that the gender-based JAI values should be used for design applications.
Parent opinions about universal influenza vaccination for infants and toddlers.

BACKGROUND Parent and caregiver opinions on the feasibility of routine influenza vaccinations for infants and toddlers are unknown. OBJECTIVE To assess among English-speaking caregivers of children aged 6 to 23 months opinions about childhood influenza vaccination and potential knowledge, attitudinal, and demographic factors that might influence such opinions. METHODS A structured, interviewer-administered survey of knowledge, attitudes, and beliefs about the influenza vaccine among parents and caregivers of children at the ambulatory pediatric clinic or the pediatric emergency department of a large tertiary care teaching hospital. The dependent measure was respondents' expressed intentions to have their eligible children immunized against influenza in the upcoming season. RESULTS We interviewed 153 caregivers. One hundred nineteen (78%) expressed intent to immunize. Safety was reported by 70 respondents (46%) as their most important concern, followed by the belief that the influenza vaccine could itself cause influenza (31 respondents, 20%). Respondents who believed that influenza was serious, that the influenza vaccine does not cause disease, or that all babies should be immunized had greater intent to immunize than those who did not (85%, 87%, and 96% vs 66%, 66%, and 49%, respectively). Those who believed that vomiting was a symptom of influenza, who did not name any vaccine adverse effect, or who had high school or lower educational levels also had greater intent to immunize (87%, 89%, and 83% vs 66%, 69%, and 69%, respectively). CONCLUSION Knowledge, attitudes, beliefs, and educational levels each had an independent influence on parents' intentions to vaccinate the child, whereas demographic factors other than education did not.
A comparison of indirect versus direct measures for assessing physical activity in the pediatric population: a systematic review.

BACKGROUND Accurate assessment of physical activity (PA) in children and adolescents is required to establish PA levels, monitor changes and inform public healthy policy. This study systematically reviews the literature to determine the extent of agreement between indirect (e.g., questionnaire) and direct (e.g., accelerometry) assessments of PA in pediatric populations (<or=19 years). METHODS Literature was identified through searching electronic databases (e.g., MEDLINE, EMBASE), websites of relevant organizations and conference abstracts until April 2007. Studies were included if they collected indirect and direct measures of PA in pediatric populations and were reported in English. Quality of included studies was appraised using a modified Downs and Black tool. RESULTS A total of 83 studies were included; 24 describing comparable data and 59 including a correlation analysis. The majority of correlations reported between indirect and direct measures were low-to-moderate (range: -0.56 to 0.89). Overall, 72% of the indirect measures overestimated the directly measured values. Combined gender, as well as male- and female-only data comparing indirect measures to accelerometery, heart rate monitoring or direct observation, all reported an overestimation by indirect method. A similar trend was observed in combined gender data comparing indirect measures with doubly labelled water; however, the opposite trend was observed in the male- and female-only data with a slight underestimation by indirect measure. CONCLUSIONS Substantial discrepancies and moderate correlations between indirect methods and direct measures of assessing PA in pediatric populations are of concern, especially when trying to establish relationships with health outcomes.
The photon pipeline revisited A hardware architecture to accelerate photon mapping

S. Singh ( ) · P. Faloutsos Computer Science Department, University of California, Los Angeles shawnsin@cs.ucla. edu Abstract With the development of real-time ray tracing in recent years, it is now very interesting to ask if realtime performance can be achieved for high-quality rendering algorithms based on ray tracing. In this paper, we propose a pipelined architecture to implement reverse photon mapping. Our architecture can use real-time ray tracing to generate photon points and camera points, so the main challenge is how to implement the gathering phase that computes the final image. Traditionally, the gathering phase of photon mapping has only allowed coarse-grain parallelism, and this situation has been a source of inefficiency, cache thrashing, and limited throughput. To avail fine-grain pipelining and data parallelism, we arrange computations so that photons can be processed independently, similar to the way that triangles are efficiently processed in traditional real-time graphics hardware. We employ several techniques to improve cache behavior and to reduce communication overhead. Simulations show that the bandwidth requirements of this architecture are within the capacity of current and future hardware, and this suggests that photon mapping may be a good choice for real-time performance in the future.
Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes

In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ. This phosphorylation was dependent on at least one functional ITAM and a functional SH2 domain within SYK. Inhibition of Src-kinases by inhibitors PP1 and PP2 did not reduce SLP-76 phosphorylation in S2 cells, suggesting an ITAM and SYK dependent, but Src-kinase independent signaling pathway. This direct ITAM/SYK/SLP-76 signaling pathway therefore differs from previously described ITAM signaling. However, the SYK-family kinase ZAP70 required the additional co-expression of the Src-family kinases Fyn or Lck to efficiently phosphorylate SLP-76 in S2 cells. This difference in Src-family kinase dependency of SYK versus ZAP70-mediated ITAM-based signaling was further demonstrated in human lymphocytes. ITAM signaling in ZAP70-expressing T cells was dependent on the activity of Src-family kinases. In contrast, Src-family kinases were partially dispensable for ITAM signaling in SYK-expressing B cells or in natural killer cells, which express SYK and ZAP70. This demonstrates that SYK can signal using a Src-kinase independent ITAM-based signaling pathway, which may be involved in calibrating the threshold for lymphocyte activation.
Cerebral haemodynamic and electrocortical CO2 reactivity in pigs anaesthetized with fentanyl, nitrous oxide and pancuronium

Cerebral haemodynamic, metabolic and electrocortical reactivity to alterations in arterial CO2, tension (PaCO2) was assessed in seven mechanically ventilated juvenile pigs to test an experimental model designed for cerebral pharmacodynamic and pharmacokinetic studies. The animals were anaesthetized with fentanyl, nitrous oxide and pancuronium and sequentially normo‐ and hyperventilated over a 100‐min period. Five measurements were made at 25‐min intervals. The cerebral blood flow (CBF) was measured with the intraarterial 133Xe technique and the cerebral metabolic rate for oxygen (CMRo2) determined from CBF and the cerebral arteriovenous oxygen content difference. A linear correlation (r = 0.845) was found between CBF and PaCO2. The cerebrovascular reactivity to hypocapnia (ΔCBF/ΔPaCO2) was maintained throughout the experimental period and amounted to (95% confidence interval) 9.1 (7.1–11.1) ml · 100 g‐1 · min‐1 · kPa‐1 within the PaCO2 range 3.3–6.3 kPa. The CMRo2 was not influenced by hyperventilation. The baseline electroencephalographic (EEG) pattern was stable at normocapnia (mean PaCO2 5.6 kPa), whereas spectral values for delta and total average voltage increased significantly (P<0.05) at extensive hypocapnia (3.5 kPa). Maintenance of cerebral CO2 reactivity and spectral EEG voltage at a stable plasma level of fentanyl is complementary to the cerebral haemodynamic and metabolic stability previously found at sustained normocapnia in this model.
How and why medically-trained managers undertake postgraduate management training - a qualitative study from Victoria, Australia.

PURPOSE The purpose of this paper is to address the research question using qualitative research methods: how and why medically trained managers choose to undertake postgraduate management training? DESIGN/METHODOLOGY/APPROACH This research used two qualitative methods to gather data. Both methods used purposeful sampling to select interviewees with appropriate management expertise, qualifications and experience. The first stage utilised convergent interviews and was exploratory. The five interviewees were managers and academics. The second stage used case research methodology and was confirmatory. The fifteen interviewees were medically qualified chief executives and chief medical officers. In total, 20 in-depth interviews were carried. Rigorous content analysis of data collected showed emergent themes. FINDINGS The first theme that emerged was that doctors move into management positions without first undertaking training. The second theme was that doctors undertake such training in the form of a masters-level degree and/or a specialist fellowship. The third theme was that effective postgraduate management training for doctors requires a combination of theory and practice. The fourth theme was that clinical experience alone does not lead to required management competencies. The fifth theme was that doctors choose to undertake training to gain credibility. RESEARCH LIMITATIONS/IMPLICATIONS This research was exploratory and descriptive in nature and limited to analytical rather than statistical generalisation. ORIGINALITY/VALUE This research has provided insights into the importance of understanding how and why doctors undertake postgraduate management training, and may assist policy makers and training providers in the development of such training for doctors.
Plasma fibrinogen and coronary heart disease in urban Japanese.

There is little information on the relation of plasma fibrinogen concentration to the risk of coronary heart disease in Asians, including Japanese, whose plasma fibrinogen concentration has been reported to be low by Western standards. The authors conducted a prospective study with 4.8 years of follow-up of 11,977 men and women aged 21-89 years (mean value of fibrinogen = 267 mg/dl) living or working in Osaka, Japan, in 1990-1996 to examine the relation of plasma fibrinogen with the incidence of coronary heart disease (myocardial infarction and angina pectoris). Mean fibrinogen concentration was 293.6 mg/dl for men who developed coronary heart disease (n = 35) compared with 261.6 mg/dl for men free of coronary heart disease (n = 8,094; difference, p < 0.01), and 355.2 mg/dl for women who developed coronary heart disease (n = 6) compared with 276.8 mg/dl for women free of coronary heart disease (n = 3,842; difference, p < 0.01). With a Cox proportional hazards model to adjust for cardiovascular risk factors, the relative risk for the highest fibrinogen quartile (> or =295 mg/dl) compared with the lowest (<228 mg/dl) was 4.8 (95% confidence interval: 1.4, 16.8, p = 0.01) for coronary heart disease, and 3.8 (95% confidence interval: 1.1, 13.4, p = 0.04) for myocardial infarction. Plasma fibrinogen is useful to predict the risk of coronary heart disease among urban Japanese, whose mean plasma fibrinogen is relatively low.