Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact and perception of they systematic response to lesbian, gay, bisexual, transgender, queer, and other sexual minority orientations (LGBTQ+) microaggressions

Lesbian, gay, bisexual, transgender, queer, and other sexual minority orientation (LGBTQ+) microaggressions are subtle behaviours that communicate hostile messages to a targeted person based upon their sexual orientation and/or gender identity (Sue et al., 2007). Quantitative research on college campuses suggests that LGBTQ+ people who have experienced LGBTQ+ microaggressions have poorer mental health outcomes, lower self-esteem related to their LGBTQ+ identity, and poorer academic performance (Woodford, Chonody, Kulick, Brennan, & Renn, 2015). There is no research to date exploring whether institutional betrayal (IB) exacerbates the mental health symptoms of those who encounter LGBTQ+ microaggressions. IB is the misconduct or mishandling of negative experience(s) by an institution when a person is, in some way, dependent upon that institution (Smith & Freyd, 2014). The current study quantitatively examined the relationship between LGBTQ+ microaggressions, IB, on mental health and academic self-concept. A total of 324 University of Regina students participated. Participants were asked to respond to a survey that assessed LGBTQ+ microaggressions, IB, academic self-concept, and mental health. Results demonstrated that both LGBTQ+ microaggressions and IB were significantly correlated with greater symptoms of depression, anxiety, and post-traumatic stress. Neither LGBTQ+ microaggressions nor IB was significantly correlated with poorer academic self-concept. A regression analysis indicated that LGBTQ+ microaggressions were more associated with negative mental health outcomes than IB. This finding suggests that reducing LGBTQ+ microaggressions that occur on campus is of importance. More research is needed to explore what combats the negative mental health outcomes that are associated with LGBTQ+ microaggressions.
Diagnosis and management of ischemic nephropathy.

Analysis of the Third National Health and Nutrition Examination Survey (1988 to 1994) suggests that chronic kidney disease (CKD) is a major public health problem (1). Approximately 11% of the US population has CKD. Roughly half have a GFR <60 ml/min per 1.73 m2 with or without kidney damage (stages 3 to 4), and half have exclusively kidney damage as manifested by microalbuminuria (stages 1 to 2) (2). It is widely recognized that the prevalence of stage 5 CKD is also increasing at a rapid rate, and it is estimated that the number of patients who have ESRD may reach 2.24 million by 2030 (3). Evidence to establish reduced GFR as an independent risk factor for cardiovascular disease (CVD) mortality has emerged. Analysis of data from several population-based epidemiologic studies (4,5) demonstrates poorer outcomes regarding stroke, myocardial infarction, and congestive heart failure (CHF) in patients with even mild compromise of kidney function. The morbidity of this group of patients constitutes an economic burden both directly in terms of resource utilization and indirectly through loss of productivity and impaired quality of life (2). Atherosclerotic renovascular disease (ARVD) can result in renovascular hypertension. However, ARVD is an increasingly recognized cause of CKD (6,7). In this article, we focus mainly on ARVD or renal artery stenosis (RAS) secondary to atherosclerosis as a cause of ischemic nephropathy. ARVD is a disease of aging, and several studies have shown its strong association with extrarenal atherosclerotic disease (8–10). Patients with ARVD seem to be at a much greater risk for cardiovascular death than for progressing to renal replacement therapy (11). Whether renal revascularization can benefit renal and cardiovascular outcomes has not been established. Atherosclerosis is the cause of approximately 90% of RAS in adults who are older …
Histological and Histometrical Study on Human Fetal Thymus

Background: The thymus is one of the primary lymphoid organs other than being the bone marrow. It is responsible for the provision of thymus-processed lymphocytes (T lymphocytes) to the whole body. Aim of the study: To study the microscopic architecture of the cortex and medulla, structure and type of epithelial cells, nature of connective tissue stroma, vasculature of thymus organ, the morphology of Hassall Corpuscle (HC). To study the histometric analysis like estimation of volume and diameter of HC at various gestational age. Method: Total 20 aborted and still born fetuses ranging from 17-39 weeks of gestation were used for the study. After embalming, meticulous dissection, thymus gland was weighed and fixed with formalin. The various histological and histometric parameters were observed. Results: The cortex and medulla were well demarcated by the 17th week. The weight and volume of the thymus were proportionately increased as the fetal age advanced. Early phase had thick mucoid interlobular septae whereas the later phase had thin, reticular interlobular septae. Four different types of HC (SHC, CHC I, CHC II and DHC) in fetus were seen. The presence of solid HC at the periphery of the medulla and degenerating HC at the central core of the medulla tends to postulate the direction of maturation which is from the periphery to the center of the medulla. Conclusion: The findings of the present study is in conformity with studies related to the volume and size of the thymus with respect to gestational ages and histological features related to parenchymal and mesenchymal tissue composition and its various components. However, the present study noted different types of Hassall’s Corpuscles which are reported in the adult thymus and the findings lead to further discussion on the maturation and differentiation of Hassall’s Corpuscles in human fetal thymus.
More Us Than Them: Positive Depictions of Mental Illness on Australian Television News

Objective: The aim of the present study was to review television news coverage of mental illness including self-depictions from people with mental illness, and views expressed by mental health experts and politicians in all 538 news and current affairs items related to mental illness broadcast on free-to-air Sydney television, May 2005–October 2007. Methods: Content and frame analysis was done of news actors (those with mental illnesses, experts and politicians) of whether depictions were positive ‘one of us’, or negative ‘one of them’. Results: Only 6% of all items with a main focus on a specific health condition, focused on mental health. Individuals with mental illness were present in 264 (49%) of 538 items, with most (174, 66%) of these self-depictions categorized as either neutral or positive. Experts and politicians overwhelmingly represented and described people with mental illnesses in neutral or positive ways (95% and 84%, respectively). Overall news angle included 299 items (55%), which were categorized as positive ‘recovery focused’ items. Another 156 items (29%) were neutral, and 62 items (12%) were classified as negative. Twenty-one (4%) had unclear or mixed themes. Conclusions: The present findings differ from previous descriptions of media depiction of mental illness, which have been largely negative. The present study provides support for the importance of involving those with histories of mental illness in news coverage.
Autoreactivity to sweat glands and nerves in clinical scabies infection

Context: Skin changes in pregnancy can be categorized as 1) physiological/hormonal, 2) alterations in pre-existing skin diseases, or 3) represent development of new dermatoses, some of which may be pregnancy specific. Case Report We describe a 19 years old female at 27 weeks gestation who presented with a rash on the face and breast, with intense pruritis. Hematoxylin and eosin demonstrated Scabies mites within the epidermis, with an intense perivascular infiltrate of lymphohistiocytic cells around the superficial dermal blood vessels. By direct immunofluorescence (DIF), human fibrinogen was also detected in the perivascular areas. DIF also revealed deposits of human IgG and complement C5-9/MAC deposits in the sweat glands, as well as in nerves surrounding the sweat glands subjacent to the mites. Overexpression of ezrin and junctional adhesion molecule antibodies close to the scabies infection sites were also seen. Conclusion: Given that the hallmark of clinical scabies is intense pruritus and that very limited information is available regarding the pathophysiology of this symptom, we suggest that the itching sensation may be exacerbated by nerves and eccrine sweat glands in close proximity to the sites of infection.
The Potosí principle: religious prosociality fosters self-organization of larger communities under extreme natural and economic conditions

We show how in colonial Potosı́ (present-day Bolivia) social and political stability was achieved through the self-organization of society through the repetition of religious rituals. Our analysis shows that the population of Potosı́ develops over the time a series of cycles of rituals and miracles as a response to social upheaval and natural disasters and that these cycles of religious performance become crucial mechanisms of cooperation among different ethnic and religious groups. Our methodology starts with a close reading and annotation of the Historia de Potosı́ by Bartolomé Arzans. Then, we model the religious cycles of miracles and rituals and store all social and cultural information about the cycles in a multirelational graph database. Finally, we perform graph analysis through traversals queries in order to establish facts concerning social networks, historical evolution of behaviors, types of participation of miraculous characters according to dates, parts of the city, ethnic groups, etc. It is also important to note that the religious activity at the group level gave native communities a way to participate in the social life. It also guaranteed that the city performed its role as producer of silver in the global economic structure of the Spanish empire. This case proves the importance of religion as a mechanism of stability and self-organization in periods of social or political turbulence. The multidisciplinary methodology combining traditional humanistic techniques with graph analysis shows a great potential for other sociological, historical, and literary problems. Correspondence: The CulturePlex Lab, Faculty of Arts and Humanities, University of Western Ontario, 1151 Richmond
Burrowing into prion disease

Mice received intra-hippocampal injections of scrapie-infected brain homogenate. Open field activity increased from around week 12 post-injection. Concomitantly the tendency to displace food from a tube inside the home cage decreased. The food was generally dug out with the feet, rather than carried by mouth, so its displacement was called burrowing. Food restriction was unnecessary for this burrowing to occur. Only later, around 18 weeks, did more general motor impairments develop. As burrowing in scrapie-infected mice decreased when open field activity increased, and preceded later motor impairments, it was not due to motor dysfunction. Burrowing is a simple, sensitive, objective, ethological measure, sensitive to preclinical prion disease. Other potential applications are in transgenic and knockout mice, models of ageing and Alzheimer's disease, and pharmacology, particularly neuroleptics.
Toll-Like Receptors Promote Inflammation in Idiopathic Inflammatory Myopathies

Abstract The roles of Toll-like receptors (TLRs) and their myeloid differentiation response gene 88 (MyD88)–dependent and MyD88-independent signaling cascade particularly with regard to the pathogenesis and regulation of immune responses in idiopathic inflammatory myopathies are unclear. We investigated these pathways in muscle biopsies from 5 cases each of polymyositis, inclusion body myositis, dermatomyositis, vasculitis-associated interstitial myositis, and noninflammatory neurogenic atrophy. Toll-like receptor 2, TLR4, TLR9, and MyD88 mRNA transcripts and protein expression were increased in all subtypes of idiopathic inflammatory myopathies. Upregulation of MyD88 was associated with increased mRNA levels of interferon-&ggr;, interleukin 12p40, and interleukin 17, suggesting NF-&kgr;B activation via the MyD88-dependent pathway in early stages. The costimulatory molecules CD80 and CD86 were expressed on inflammatory infiltrates in idiopathic inflammatory myopathies and may additionally contribute to activation of the MyD88-independent pathway, leading to nuclear factor-&kgr;B activation in late stages. Our data suggest that nuclear factor-&kgr;B activation via both the MyD88-dependent and the MyD88-independent pathways contributes to the proinflammatory milieu in idiopathic inflammatory myopathies.
Handoff management with mobility estimation in hierarchical systems

We propose some algorithms for channel assignment and handover management in multitier systems. The algorithms are based on user speed estimation and aim to minimize signalling due to interlayer handoffs. They abandon the classic assumption of constant user speed during the call and adopt a realistic mobility model for users. The performance is studied in different environments and under various traffic conditions and compared with algorithms based on assumptions traditionally adopted in the literature. Results show that the proposed algorithms are successful in lowering the number of interlayer handoff requests while not adversely affecting call blocking and forced termination probabilities. This is paid in terms of a decrease in the system capacity.
Stimulation of bone formation in the expanding inter-premaxillary suture by vitamin E, in rat

Objective: The aim of this study was to evaluate the effects of vitamin E (α-tocopherol) administration on bone formation in response to expansion of the inter-premaxillary suture, in rats, histomorphometrically. Methods: Thirty 50 - 60 day old Wistar rats were separated into five equal groups (one control and four experimental). All groups were subjected to inter-premaxilla expansion with 50-gram of force. Six control animals received saline solution (Group I) and three experimental groups were treated with a single dose of α-tocopherol injected into the inter-premaxillary suture after one day after appliance placement (Group II: 2 mg/kg; Group III: 10 mg/kg; and Group IV: 50 mg/kg). A further group of six animals received three injections of 10 mg/kg α-tocopherol, one each on days 3, 6, and 9 (Group V). Bone formation in the suture was evaluated by bone histomorphometry. Kruskal-Wallis rank and Mann-Whitney U tests were used for statistical evaluation at p ＜ 0.05 level. Results: New bone area, bone perimeter, feret’s diameter and newly formed bone measurements were significantly higher in the experimental groups than the control (p ＜ 0.001). Bone architecture in α-tocopherol administrated groups was improved, and bone formation during the expansion period was stimulated significantly, in a dose-dependent manner. Conclusions: The application of α-tocopherol during the early stages to orthopedically expanded inter-premaxillary suture areas may stimulate bone formation and shorten the retention period, in rats. (Korean J Orthod 2009;39(5):337-347)
Intellectual Capital, Corporate Culture and Performance of Firms Listed on Nairobi Securities Exchange

The broad objective of this study was to establish the moderating effect of corporate culture on the relationship between intellectual capital and organizational performance of firms listed on Nairobi Securities Exchange. The review of literature provided conceptual and empirical gaps that formed the basis of the conceptual hypotheses. Two hypotheses were deduced from general objective: Intellectual capital has a significant influence on corporate performance; corporate culture moderates the relationship between intellectual capital and corporate performance. A cross-section research design was adopted. A survey questionnaire was the main tool of data collection and was distributed to the 50 heads of human resource departments in the different firms’ period covering four financial years from 2009 to 2012. The study also utilized secondary data obtained from Capital Market Authority Statistical bulletins and Nairobi Securities Exchange Handbook 2012-2013 to collect data on financial performance (ROA, ROE, and Dividend Yield). Data were tested for reliability results showing that study dimensions were reliable, apart from task-oriented culture that had a Cronbach alpha of 0.262, thus being not considered for further analysis; thus the study relied on employee-oriented culture as a measure of corporate culture. The hypotheses were tested using multiple regression analysis and hierarchical regression respectively. Multiple regression analysis showed that intellectual capital had a significant influence on non-financial performance and no significant influence on financial measures of performance (ROA, ROE, and Dividend Yield). Test for moderation showed that the interaction term was not significant and thus, employee-oriented culture did not moderate the relationship between intellectual capital and corporate performance. The study demonstrates importance of the influence of intellectual capital on non-financial performance of firms listed on Nairobi Securities Exchange. The results show that interplay among human capital, social capital, and organization capital is important for firms listed on Nairobi Securities Exchange and that the firms should nurture the employees into sharing their knowledge by creating internal and external networks and also creating support system within the organization to retain the knowledge.
Efficient Data Center Flow Scheduling Without Starvation Using Expansion Ratio

Existing data center transport protocols are usually based on the Processor Sharing (PS) policy and/or the Shortest Remaining Processing Time (SRPT) policy. PS divides link bandwidth equally between competing flows, thus it fails to achieve optimal average flow completion time (FCT). SRPT prioritizes flows that have the shortest remaining processing time and provides near-optimal average FCT, but it may cause long flows to suffer unfair delays, or even starve them. In fact, these two types of policies represent two directions in the design space: PS prefers fairness (in terms of starvation freedom) while SRPT favors efficiency (in terms of average FCT). In this paper, we propose a novel metric, expansion ratio, which enables us to strike a balance between SRPT and PS. We design MERP that achieves efficient flow scheduling without starvation. MERP takes care of both average and tail FCTs by minimizing the expansion ratio of competing flows in a lexicographically manner. MERP controls the sending rate of competing flows via synchronized virtual deadlines and routes flows in a downstream-aware manner that reacts quickly to link failures. We evaluate MERP using extensive NS2-based simulations. Results show that, under various traffic loads, MERP reduces the tail FCT significantly with a negligible increase of average FCT compared with pFabric, and MERP reduces the average FCT notably compared with ECMP and CONGA when link failures occur.
Treatment of osteoarthritis with Pycnogenol®. The SVOS (San Valentino osteo‐arthrosis study). evaluation of signs, symptoms, physical performance and vascular aspects

The aim of this double‐blind, placebo‐controlled study was to evaluate the efficacy of 100 mg Pycnogenol® daily (oral capsules) in a 3 month study in patients with osteoarthritis (OA). OA symptoms were evaluated by WOMAC scores, mobility by recording their walking performance (treadmill). Treatment (77 patients) and placebo group (79) were comparable for age, sex distribution, WOMAC scores, walking distances and use of antiinflammatory drugs. The global WOMAC score decreased by 56% (p < 0.05) in the treatment group versus 9.6% in the placebo group. Walking distance in the treadmill test was prolonged from 68 m at the start to 198 m after 3 months treatment (p < 0.05), under placebo, from 65 m to 88 m (NS). The use of drugs decreased by 58% in the treatment group (p < 0.05) versus 1% under placebo. Gastrointestinal complications decreased by 63% in the treatment group, but only 3% under placebo. Overall, treatment costs were reduced significantly compared with placebo. Foot edema was present in 76% of the patients of the treatment group at inclusion and in 79% of the controls. After 3 months edema decreased in 79% of Pycnogenol patients (p < 0.05) vs 1% in controls. In conclusion, Pycnogenol offers an option for reduction of treatment costs and side effects by sparing antiinflammatory drugs. Copyright © 2008 John Wiley & Sons, Ltd.
[Evaluation of different clinical samples and cell lines in the isolation of enterovirus in pediatric patients].

BACKGROUND To evaluate prospectively the efficacy of different clinical samples and cellular lines in the isolation of Enteroviruses from pediatric patients. METHODS In the period july-1997 to july-1999 we analyze the samples of 102 pediatric patients (< 2 years old) with an unknown febrile etiology syndrome. After the process of decontamination the samples were inoculated in the MRC-5, Hep-2 and Vero cell lines by the shell-vial assay. After 2-3 days of incubation the monolayers were stained by a monoclonal antibody against VP1; then the strains were identified as Poliovirus, ECHO-virus or Coxsacke by specific antibodies. RESULTS 96 clinical samples were studied (45 pharyngeal swabs, 28 feces, 13 cerebrospinal fluid, 5 bloods, 4 urines and one bronchoalveolar lavage). Enteroviruses were isolated in 48 patients (47%), corresponding to 60 clinical samples (62.5%). The enteroviruses were isolated in 75.5% of pharyngeal swabs, 71.4% of feces, 30.7% of cerebrospinal fluid, one blood (20%) and the bronchoalveolar lavage. 28 patients presented simultaneously both pharyngeal and rectal swabs; in this group the use of both samples permitted the isolation of Enteroviruses in 26 cases (92.8%). Of 60 Enteroviruses, 59 (98.3%) were isolated in the MRC-5 cell line, 23 (38.3%) in the Hep-2, and 14 (23.3%) in the Vero; the MRC-5 demonstrated a significant difference in the isolation of Enteroviruses compared with the other cell lines. The Enteroviruses were identified as 30 (50%) ECHO-virus, 15 (25%) as Poliovirus vaccine, 12 (20%) could not to be identified and in 3 cases (5%) no growth of virus was detected in the culture. The MRC-5 cell line was significatively superior to the other in the isolation of the different Enteroviruses. CONCLUSIONS To obtain the maximum diagnostic efficacy in front a patient with a possible infection by Enteroviruses, is necessary to use different clinical samples, specially the more related to the infection focci (cerebrospinal fluid or blood). The MRC-5 cell line has been the most efficace in the isolation of Enteroviruses independently of the type of clinical sample or the viral genus. The shell-vial assay is a good method for the isolation and identification of Enteroviruses isolated from clinical samples.