Miracle-dz/UniFAR-FTUs huggingface dataset:
Instability due to cross-phase modulation in the normal-dispersion regime.

The interaction of two light waves, having different frequencies and propagating in a dispersive nonlinear medium, is studied using the method of Zakharov (Zh. Eksp. Teor. Fiz. 51, 1107 (1966) [Sov. Phys. JETP 24, 740 (1967)]). This method does not require the sidebands of the incident waves to have frequencies comparable to those of the incident waves, as do the coupled nonlinear Schrodinger equations that are normally used to model this interaction. It is shown that cross-phase modulation does not necessarily lead to instability of the incident waves. In particular, two light waves propagating in the normal-dispersion regime of a conventional single-mode fiber are stable
Characterization of lymphopenia in patients with MS treated with dimethyl fumarate and fingolimod

Objective: Lymphopenia is a common occurrence of disease-modifying therapies (DMTs) for relapsing-remitting MS (RRMS). The aim of this study was to dissect the prevalence of various lymphocyte subsets in patients with RRMS treated with 2 DMTs commonly associated with lymphopenia, dimethyl fumarate (DMF), and fingolimod (FTY). Methods: Multicolor flow cytometry and multiplex assays were used to identify up to 50 lymphocyte subpopulations and to examine the expression of multiple cytokines in selected patients. We compared patients untreated (NT) or treated with FTY or DMF who did (DMF-L) or did not (DMF-N) develop lymphopenia. Results: All FTY patients developed lymphopenia in both T-cell and B-cell compartments. CD41 T cells were more affected by this treatment than CD81 cells. In the B-cell compartment, the CD271IgD2 subpopulation was reduced. T cells but not B cells were significantly reduced in DMF-L. However, within the B cells, CD271 cells were significantly lower. Both CD41 and CD81 subpopulations were reduced in DMF-L. Within the remaining CD41 and CD81 compartments, there was an expansion of the naive subpopulation and a reduction of the effector memory subpopulation. Unactivated lymphocyte from DMF-L patients had significantly higher levels of interferon-γ, interleukin (IL)-12, IL-2, IL-4, IL-6, and IL-1β compared with DMF-N. In plasma, TNFβ was significantly higher in DMF-N and DMF-L compared with NT, whereas CCL17 was significantly higher in DMF-L compared with NT and DMF-N. Conclusions: This study shows that different treatments can target different lymphocyte compartments and suggests that lymphopenia can induce compensatory mechanisms to maintain immune homeostasis.
Network‐based analysis reveals stronger local diffusion‐based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders

Neuroimaging has uncovered both long‐range and short‐range connectivity abnormalities in the brains of individuals with autism spectrum disorders (ASD). However, the precise connectivity abnormalities and the relationship between these abnormalities and cognition and ASD symptoms have been inconsistent across studies. Indeed, studies find both increases and decreases in connectivity, suggesting that connectivity changes in the ASD brain are not merely due to abnormalities in specific connections, but rather, due to changes in the structure of the network in which the brain areas interact (i.e., network topology). In this study, we examined the differences in the network topology between high‐functioning ASD patients and age and gender matched typically developing (TD) controls. After quantitatively characterizing the whole‐brain connectivity network using diffusion tensor imaging (DTI) data, we searched for brain regions with different connectivity between ASD and TD. A measure of oral language ability was then correlated with the connectivity changes to determine the functional significance of such changes. Whole‐brain connectivity measures demonstrated greater local connectivity and shorter path length in ASD as compared to TD. Stronger local connectivity was found in ASD, especially in regions such as the left superior parietal lobule, the precuneus and angular gyrus, and the right supramarginal gyrus. The relationship between oral language ability and local connectivity within these regions was significantly different between ASD and TD. Stronger local connectivity was associated with better performance in ASD and poorer performance in TD. This study supports the notion that increased local connectivity is compensatory for supporting cognitive function in ASD. Hum Brain Mapp 35:396–413, 2014. © 2012 Wiley Periodicals, Inc.
Heterogeneity of plasma low‐density lipoproteins and atherosclerosis risk

Increased levels of IDL and small, dense LDL are associated with the risk of coronary artery disease. Possible mechanisms include increased susceptibility of small, dense LDL to oxidation, and to other pathologic effects, such as increased retention in the arterial wall. Beneficial effects of a low-fat diet and certain lipid-lowering therapies on the levels and properties of small, dense LDL or their precursors may contribute substantially to the reductions in coronary atherosclerosis observed in several Iipid-lowermg trials.
Absorption Characteristics of Vertebrate Non-Visual Opsin, Opn3

Most animals possess multiple opsins which sense light for visual and non-visual functions. Here, we show spectral characteristics of non-visual opsins, vertebrate Opn3s, which are widely distributed among vertebrates. We successfully expressed zebrafish Opn3 in mammalian cultured cells and measured its absorption spectrum spectroscopically. When incubated with 11-cis retinal, zebrafish Opn3 formed a blue-sensitive photopigment with an absorption maximum around 465 nm. The Opn3 converts to an all-trans retinal-bearing photoproduct with an absorption spectrum similar to the dark state following brief blue-light irradiation. The photoproduct experienced a remarkable blue-shift, with changes in position of the isosbestic point, during further irradiation. We then used a cAMP-dependent luciferase reporter assay to investigate light-dependent cAMP responses in cultured cells expressing zebrafish, pufferfish, anole and chicken Opn3. The wild type opsins did not produce responses, but cells expressing chimera mutants (WT Opn3s in which the third intracellular loops were replaced with the third intracellular loop of a Gs-coupled jellyfish opsin) displayed light-dependent changes in cAMP. The results suggest that Opn3 is capable of activating G protein(s) in a light-dependent manner. Finally, we used this assay to measure the relative wavelength-dependent response of cells expressing Opn3 chimeras to multiple quantally-matched stimuli. The inferred spectral sensitivity curve of zebrafish Opn3 accurately matched the measured absorption spectrum. We were unable to estimate the spectral sensitivity curve of mouse or anole Opn3, but, like zebrafish Opn3, the chicken and pufferfish Opn3-JiL3 chimeras also formed blue-sensitive pigments. These findings suggest that vertebrate Opn3s may form blue-sensitive G protein-coupled pigments. Further, we suggest that the method described here, combining a cAMP-dependent luciferase reporter assay with chimeric opsins possessing the third intracellular loop of jellyfish opsin, is a versatile approach for estimating absorption spectra of opsins with unknown signaling cascades or for which absorption spectra are difficult to obtain.
Phytochemistry and Free radical scavenging activities of Oroxylum indicum

The present study estimates the free radical scavenging activity of the different extracts of Oroxylum indicum in different assays viz. total antioxidant assay and β-carotene bleaching assay. The stem bark powder of the plant was extracted with different solvents by sequential extraction method in the order of increasing polarity using soxhlet apparatus. The phytochemistry of the plant was qualitatively analyzed using various methods. The scavenging activity of ethanol and chloroform extracts showed high potency compared to the other extracts. The ethanol extract exhibited maximum antioxidant potential in β-carotene bleaching assays whereas chloroform extract showed maximum reducing power in total antioxidant activity. The variation amongst the antioxidant potential may be due to the phytochemical diversity. The maximum antioxidant potential of ethanol extract may be due to its free radical scavenging activities, while the chloroform extract may be due to its reducing potential. Studies are in progress to evaluate the effect of extract/ fractions in other antioxidant assays and identify the factors responsible for the activity.
Maintenance of Double-Stranded Telomeric Repeats as the Critical Determinant for Cell Viability in Yeast Cells Lacking Ku

ABSTRACT The Saccharomyces cerevisiae Ku complex, while important for nonhomologous DNA end joining, is also necessary for maintaining wild-type telomere length and a normal chromosomal DNA end structure. Yeast cells lacking Ku can grow at 23°C but are unable to do so at elevated temperatures due to an activation of DNA damage checkpoints. To gain insights into the mechanisms affected by temperature in such strains, we isolated and characterized a new allele of the YKU70 gene, yku70-30ts . By several criteria, the Yku70-30p protein is functional at 23°C and nonfunctional at 37°C. The analyses of telomeric repeat maintenance as well as the terminal DNA end structure in strains harboring this allele alone or in strains with a combination of other mutations affecting telomere maintenance show that the altered DNA end structure in yeast cells lacking Ku is not generated in a telomerase-dependent fashion. Moreover, the single-stranded G-rich DNA on such telomeres is not detected by DNA damage checkpoints to arrest cell growth, provided that there are sufficient double-stranded telomeric repeats present. The results also demonstrate that mutations in genes negatively affecting G-strand synthesis (e.g., RIF1) or C-strand synthesis (e.g., the DNA polymerase α gene) allow for the maintenance of longer telomeric repeat tracts in cells lacking Ku. Finally, extending telomeric repeat tracts in such cells at least temporarily suppresses checkpoint activation and growth defects at higher temperatures. Thus, we hypothesize that an aspect of the coordinated synthesis of double-stranded telomeric repeats is sensitive to elevated temperatures.
Student injuries in the dissecting room

Cadaver dissection is the first opportunity for many students to practice handling human tissue and is their first exposure to the occupational hazards involved with this task. Few studies examine dissection room injuries to ascertain the dangers associated with dissecting. We performed a retrospective cohort analysis of dissection room injuries from four student cohorts over an eleven‐year period (2001–2011), including second‐year medical students, third‐year medical students, second‐year dental students, and third‐year science students. Injury data included activity causing injury, object responsible, and injury site. A total of 163 injuries during 70,039 hours of dissection were recorded, with 66 in third‐year medical students, 42 in second‐year medical students, 36 in third‐year science students, and 16 in second‐year dental students. The overall rate was 2.87 injuries per 1,000 dissection hours, with second‐year medical students most frequently injured (5.5 injuries per 1,000 hours); third‐year medical students were least frequently injured (1.3 injuries per 1,000 hours). A significant difference in injury rates between student groups indicated a higher than expected injury rate to second‐year medical students and lower than expected rates to third‐year medical students. Injury rates increased for most groups between 2001–2006 and 2007–2011 periods. Most injuries (79%) were from scalpel cuts to the finger or thumb. This study provides injury rates for dissection room injuries to students, indicating differences in injury frequency between cohorts and an increase in injury rate over time. As scalpel cuts were the most likely injury mechanism, targeting scalpel handling with preventative strategies may reduce future injury risk. Anat Sci Educ 6: 404–409. © 2013 American Association of Anatomists.
BTS guidelines for the management of community acquired pneumonia in adults: update 2009

A summary of the initial management of patients admitted to hospital with suspected community acquired pneumonia (CAP) is presented in fig 8. Tables 4 and 5, respectively, summarise (1) the relevant microbiological investigations and (2) empirical antibiotic choices recommended in patients with CAP. Figure 8 Hospital management of community acquired pneumonia (CAP) in the first 4 h. CXR, chest x ray; DBP, diastolic blood pressure; SBP, systolic blood pressure. View this table: Table 4 Recommendations for the microbiological investigation of community acquired pneumonia (CAP) View this table: Table 5 Initial empirical treatment regimens for community acquired pneumonia (CAP) in adults ### Investigations ( Section 5 ) #### When should a chest radiograph be performed in the community? 1. It is not necessary to perform a chest radiograph in patients with suspected CAP unless: 2. #### When should a chest radiograph be performed in hospital? 1. All patients admitted to hospital with suspected CAP should have a chest radiograph performed as soon as possible to confirm or refute the diagnosis. [D] The objective of any service should be for the chest radiograph to be performed in time for antibiotics to be administered within 4 h of presentation to hospital should the diagnosis of CAP be confirmed. #### When should the chest radiograph be repeated during recovery? 1. The chest radiograph need not be repeated prior to hospital discharge in those who have made a satisfactory clinical recovery from CAP. [D] 2. A chest radiograph should be arranged after about 6 weeks for all those patients who have persistence of symptoms or physical signs or who are at higher risk of underlying malignancy (especially smokers and those aged >50 years) whether or not they have been admitted to hospital. [D] 3. Further investigations which may include bronchoscopy should be considered in patients with persisting signs, symptoms …
A predictive model for the permeability tensor of magnetized heterogeneous materials

This paper describes a mathematical model enabling the calculation of the effective permeability tensor of heterogeneous magnetic materials set in various magnetization states. The theoretical approach we propose permits to predict the microwave behavior of unsaturated magnetic loaded composites as well as those of unsaturated polycrystalline ferrites. The model gives all the complex components of the permeability tensor in a single calculation phase whatever the magnetization state of the material is. This is useful for the computer-aided design of microwave magnetic devices. The calculation of the effective permeability tensor is carried out from a limited number of parameters: saturation magnetization, anisotropy field, damping factor, external dc field strength, concentration, and shape of the magnetic particles or domains. The model is predictive in the way that the magnetization state of the material is determined from the strength of the external dc magnetic field applied on the material.
Self-Specific MHC Class II-Restricted CD4−CD8− T Cells That Escape Deletion and Lack Regulatory Activity1

In the presence of the I-Eα protein, transgenic (Tg) mice expressing the 1H3.1 αβ TCR that is specific for the Eα52–68:I-Ab complex display drastic intrathymic deletion. Although peripheral T cells from these mice remained unresponsive to the Eα52–68:I-Ab complex, they contained a subpopulation able to specifically react to this complex in the presence of exogenous IL-2, indicating that some 1H3.1 αβ TCR Tg T cells have escaped clonal deletion and efficiently populated the periphery. IL-2-dependent, Eα52–68:I-Ab complex-responsive T cells were CD4−CD8− and expressed the 1H3.1 αβ TCR. Such T cells could develop intrathymically, did not show sign of regulatory/suppressor activity, displayed a typical naive phenotype, and seemed to persist in vivo over time. CD4−CD8− TCR Tg T cells were also detected when the surface density of the deleting ligand was increased on MHC class II+ cells. In addition, the development of CD4−CD8− 1H3.1 αβ TCR Tg T cells could be supported by I-Ab molecules. These observations indicate that CD4 surface expression neither specifies, nor is required for, the thymic export of mature thymocytes expressing a MHC class II-restricted αβ TCR. The data also show that, although the avidity of the interaction involved in intrathymic deletion is significantly lower than that involved in mature T cell activation, its range can be large enough to be influenced by the presence or absence of coreceptors. Finally, the margin created by the absence of CD4 coreceptor was substantial because it could accommodate various amounts of the deleting ligand on thymic stromal cells.
Recombination pathway specificity of Chi.

Chi in phage lambda is a genetic element increasing the rate of recombination in its vicinity. Chi activity requires the wild-type functions of both the recA and the recB genes of E. coli. In terms of the pathway concept for recombination, Chi is active in the RecBC pathway and inactive in the Red, RecE. , and RecF pathways.
Isosorbide in the medical treatment of infantile hydrocephalus.

✓ The author reports the methods, results and complications of isosorbide therapy in 60 patients with various types of infantile hydrocephalus. Treatment was monitored by serial measurements of head circumference, assessment of fontanel tension, air ventriculography, and echoencephalography. Frequent estimation of plasma electrolytes, urea, and Astrup figures were found essential to guard against serious hypernatremia and acidosis, especially if higher doses were used. Infants with moderate hydrocephalus and those whose shunt was removed temporarily because of infection did particularly well under isosorbide. Cases of severe hydrocephalus rarely responded to therapy and in these, at best, only a delay before surgical therapy was achieved.
Magnetic, Structural, and Particle Size Analysis of Single- and Multi-Core Magnetic Nanoparticles

We have measured and analyzed three different commercial magnetic nanoparticle systems, both multi-core and single-core in nature, with the particle (core) size ranging from 20 to 100 nm. Complementary analysis methods and same characterization techniques were carried out in different labs and the results are compared with each other. The presented results primarily focus on determining the particle size-both the hydrodynamic size and the individual magnetic core size-as well as magnetic and structural properties. The used analysis methods include transmission electron microscopy, static and dynamic magnetization measurements, and Mössbauer spectroscopy. We show that particle (hydrodynamic and core) size parameters can be determined from different analysis techniques and the individual analysis results agree reasonably well. However, in order to compare size parameters precisely determined from different methods and models, it is crucial to establish standardized analysis methods and models to extract reliable parameters from the data.
Contributions of joint rotations to ball release speed during cricket bowling: A three-dimensional kinematic analysis

Abstract The purpose of this study was to discover the contributions of individual upper body segmental rotations to ball release speed for cricket bowling and determine whether attempting to forcefully flex the lower trunk leads to an increase in ball release speed and bowling accuracy. Three dimensional kinematic data of eight male fast bowlers were recorded by a Vicon motion capture system under three cricket bowling conditions: (1) participants bowled at their stock delivery speeds (sub-max condition), (2) participants bowled at their absolute maximal speeds (max condition), and (3) participants bowled at their absolute maximal speeds but forced to flex the lower trunk (max-trunk condition). The accuracy of each delivery was also measured. The results showed that the average ball release speeds for the max-trunk condition were faster than the other two conditions. A general pattern of proximal to distal sequencing was observed for all three conditions. There was a slight decrement in accuracy seen in the max-trunk condition with respect to the other two conditions. For all three conditions, the upper arm rotation made the largest contribution, followed in turn by torso and thorax rotation, pelvis rotation, linear velocity of pelvis, and forearm and hand rotation.
Amygdala volume in a population with special educational needs at high risk of schizophrenia

Background The mildly learning disabled population has a three-fold elevated risk for schizophrenia. It has been proposed that in some individuals this cognitive limitation is a pre-psychotic manifestation of early onset schizophrenia. We examined clinical and neuroanatomical measures of a putative extended phenotype of schizophrenia in an adolescent population receiving special educational assistance. We predicted that people with intellectual impairment and schizotypal features would exhibit amygdala volume reduction as one of the neuroanatomical abnormalities associated with schizophrenia. Method Assessment by clinical interview, neuropsychological assessment and magnetic resonance imaging scanning was carried out in 28 intellectually impaired individuals identified as being at elevated risk of schizophrenia due to the presence of schizotypal traits, 39 intellectually impaired controls and 29 non-intellectually impaired controls. Amygdala volume was compared in these three groups and the relationship between symptomatology and amygdala volume investigated. Results Right amygdala volume was significantly increased in the elevated risk group compared with the intellectually impaired controls (p=0.05). A significant negative correlation was seen between left amygdala volume and severity of negative symptoms within this group (p<0.05), but not in either control group. Conclusions Intellectually impaired subjects judged to be at elevated risk of schizophrenia on the basis of clinical assessment exhibit structural imaging findings which distinguish them from the generality of learning disabled subjects. Within this population reduced amygdala volume may be associated with negative-type symptoms and be part of an extended phenotype that reflects particularly elevated risk and/or early manifestations of the development of psychosis.