Miracle-dz/UniFAR-FTUs huggingface dataset:
Public Sense of Water Fluoridation as Reflected on Twitter 2009–2017

Though controversial, water fluoridation has been hailed as one of the top-ten public-health achievements of the 20th century in the United States of America. In this article, we aim to investigate the public sense of water fluoridation as reflected on Twitter, using data from 2009 to 2017. To this end, tweets related to water fluoridation were collected using queries such as “fluoridated water or fluoride water,” “water fluoridation or fluoridation of water,” and hashtags related to water fluoridation. The collected tweets (n = 218,748) were examined through informetric, linguistic (word sentiment, word frequency, and word network analyses), and issue tweet analyses. We found that Twitter users who tweeted about water fluoridation in English between 2009 and 2017 constituted about <0.01% of all users including non-English users. In their tweets, words such as “poison” and “waste” were the strong negative sentiment words most often used. Of the top 30 words most frequently used, words related to information sources on water fluoridation and the safety of water fluoridation appeared more often than words related to its efficacy. Additionally, the words related to information sources on water fluoridation and the safety of water fluoridation were found to be core terms in the sentences of tweet mentions. Our linguistic analyses indicate that Twitter users responded sensitively to words that emphasize negative aspects of fluoridation. This is clearly shown in our issue tweet analysis, where tweet mentions expressing negative opinions about water fluoridation accounted for at least 59.2% of all mentions. By contrast, <15% of tweet mentions were found to be positive. These findings suggest that professionals need to reevaluate the current state of online information about water fluoridation, and improve it in a way so that the public can easily access reliable information sources.
ay 2 00 7 POWDERED ACTIVATED CARBONS FROM PINUS CARIBAEA SAWDUST

Activated carbons with different porous structures have been prepared from Pinus caribaea sawdust through the use of CO2 and steam as activating agents. The evolution of the Brunauer-EmmettTeller (BET) surface area upon activation becomes fairly similar in both cases, and values above 1000 m/g can be reached at high burn-off levels. Activation with steam produces a more developed porous structure, with a substantially higher contribution of mesoporosity, than does activation with CO2. Increasing the activation temperature leads in both cases to a wide pore-size distribution. The presence of a well-developed mesoporosity makes the resulting products good candidates for adsorbents for water and wastewater treatment. For these purposes, the characteristics of these activated carbons are comparable to those used as commercial adsorbents in those fields, showing in the case of the steam-activated carbons, a somewhat higher mesopore volume than many of the commercial products while maintaining similar surface area values SEPARATION SCIENCE AND TECHNOLOGY, 36(14), 3191–3206 (2001) Copyright © 2001 by Marcel Dekker, Inc. www.dekker. com 3191 *Corresponding author. Fax: 34-91-3974187; E-mail: juanjo.rodriguez@uam.es D ow nl oa de d By : [ U ni ve rs id ad D e M al ag a] A t: 09 :2 2 9 M ay 2 00 7 ORDER REPRINTS to them. The relative simplicity of the process makes the production of steam-activated carbons a feasible and economically valuable alternative for sawmill wastes.
Television consumption drives perceptions of female body attractiveness in a population undergoing technological transition.

Perceptions of physical attractiveness vary across cultural groups, particularly for female body size and shape. It has been hypothesized that visual media propagates Western "thin ideals. " However, because cross-cultural studies typically consider groups highly differentiated on a number of factors, identifying the causal factors has thus far been impossible. In the present research, we conducted "naturalistic" and controlled experiments to test the influence of media access on female body ideals in a remote region of Nicaragua by sampling from villages with and without regular TV access. We found that greater TV consumption remained a significant predictor of preferences for slimmer, curvier female figures after controlling for a range of other factors in an ethnically balanced sample of 299 individuals (150 female, aged 15-79) across 7 villages. Within-individual analyses in 1 village over 3 years also showed an association between increased TV consumption and preferences for slimmer figures among some participants. Finally, an experimental study in 2 low-media locations demonstrates that exposure to media images of fashion models can directly impact participants' body size ideals. We provide the first converging cross-sectional, longitudinal, and experimental evidence from field-based research, that media exposure can drive changes in perceptions of female attractiveness. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Market Risk Factor and the Weighted Repeated Sales Method

This paper identifies a critical issue in the Weighted Repeated Sales (WRS) method - the omission of market risk in the weight estimation model specified by Case and Shiller (1989). It demonstrates that the omission of market risk is conceptually unjustified. Through extensive examination of the real estate market risk, the study not only proposes a modified WRS model that is empirically supported, but also contributes to the broad discussion on the holding period dependence of real estate risk. It also shows that the Case-Shiller weighting method is likely to be mis-specified in nine of the ten cities where the Case-Shiller metro indices are "tradable" with housing options and futures contracts listed on the Chicago Mercantile Exchange. Using a large sample of repeated sales from Washington DC area, the original repeated sales method of Bailey, Muth, and Nourse (1963) and the Case-Shiller method are compared against the modified WRS, and the results indicate that market risk plays an important role in the index estimation.
Phylogenetic positions of Actites megalocarpa and Sonchus hydrophilus (Sonchinae: Asteraceae) based on ITS and chloroplast non-coding DNA sequences

Phylogenetic positions of the Australian endemic taxa Actites megalocarpa and Sonchus hydrophilus within the subtribe Sonchinae were determined on the basis of ITS sequences of nuclear rDNA and the psbA-trnH (GUG) intergenic spacer of chloroplast DNA. Both ITS and cpDNA phylogenies suggest that the monotypic genus Actites is not closely related to the members of Sonchus section Asperi, as previously suggested. Rather, this study indicates that it is more closely related to the members of Sonchus sections Maritimi (S. maritimus) and Arvenses (S. arvensis). It also suggests that S. maritimus from section Maritimi is one of the closest relatives of Actites in Australia, although an alternative origin from section Arvenses is possible. Actites and Embergeria, once treated as congeneric taxa, appear to have originated independently in Australia and New Zealand, respectively. Sonchus hydrophilus is closely related to the S. asper complex, S. oleraceus and S. kirkii. This study suggests that S. kirkii may be involved in the origin of S. hydrophilus in Australia.
Rapid Whole Genome Sequencing and Fulfilling the Promise of Precision Pediatric Critical Care.

or pleiotropic illness presentations. Addition-ally, WGS does not obviate the need for functional verification of novel mutations. Individual patient results continue to be limited by the challenges frequently encountered in the study of rare diseases using NGS. False positives can occur due to erroneous classification of individual variants as pathogenic or likely pathogenic on the basis of a handful of cases. As a result of the burgeoning nature of precision medicine, currently, our diagnostic capacity far outstrips our prognostic ability. Addi-tionally, the current emphasis on precision medicine places clinicians at risk of overemphasizing a single mutation and neglecting care environment, illness course, and genetic back-ground. Although NGS technologies offer the capacity to in-terrogate gene-gene interactions, multigenic inheritance, and cases of epistasis and resilience (where the effect of a single
A rare case of intracranial extra-axial ependymoma

ABSTRACT Intracranial extra-axial ependymomas (IEAEs) are extremely uncommon tumors and they could have a wide spectrum of clinical and radiological features. Here we report morphological features of an extra-axial ependymoma (radiology, histology and ultrastructural details) which mimicked the presentation of meningioma.
MHD Instabilities in Accretion Disks and Their Implications in Driving Fast Magnetic Reconnection

Magnetohydrodynamic instabilities play an important role in accretion disk systems. Besides the well-known effects of magnetorotational instability (MRI), the Parker–Rayleigh–Taylor instability (PRTI) also arises as an important mechanism to help in the formation of the coronal region around an accretion disk and in the production of magnetic reconnection events similar to those occurring in the solar corona. In this work, we have performed three-dimensional magnetohydrodynamical (3D-MHD) shearing-box numerical simulations of accretion disks with an initial stratified density distribution and a strong azimuthal magnetic field with a ratio between the thermal and magnetic pressures of the order of unity. This study aimed at verifying the role of these instabilities in driving fast magnetic reconnection in turbulent accretion disk/corona systems. As we expected, the simulations showed an initial formation of large-scale magnetic loops due to the PRTI followed by the development of a nearly steady-state turbulence driven by both instabilities. In this turbulent environment, we have employed an algorithm to identify the presence of current sheets produced by the encounter of magnetic flux ropes of opposite polarity in the turbulent regions of both the corona and the disk. We computed the magnetic reconnection rates in these locations, obtaining average reconnection velocities in Alfvén speed units of the order of 0.13 ± 0.09 in the accretion disk and 0.17 ± 0.10 in the coronal region (with mean peak values of order 0.2), which are consistent with the predictions of the theory of turbulence-induced fast reconnection.
Overweight/obesity in teachers: prevalence and associated factors

The study aimed to assess the prevalence and sociodemographic, occupational and lifestyle factors associated with overweight/obesity in state teachers from a northeastern Brazilian city. A cross-sectional study involving teachers from the city of Jequie-BA initially selected by cluster sampling (schools) was conducted. The sample consisted of 300 teachers, including 72.7% (n=214) women. Sociodemographic, occupational and lifestyle data were investigated. Body weight and height were obtained by self-report. Prevalence ratios and 95% confidence intervals were estimated and a level of significance of 5% was adopted. The overall prevalence of overweight/obesity was 47.2%. The prevalence was significantly higher among male teachers (58.2%), married or cohabitating subjects (49.1%), whites and mulattoes (87.6%), teachers with an income > R$ 2,002.00 and a permanent contract (45.9%), and subjects who did not consume fruits or vegetables (49.1%). After multivariate analysis, only gender (95% CI = 0.16-0.66) and consumption of fruits and vegetables (95% CI = 0.25-0.98) remained significantly associated with overweight/obesity among teachers. These findings promote debate on the need for actions designed to encourage the adoption of an active lifestyle by the teacher population.
In Silico Analysis of Mobilome Response to Salt Stress in Phaseolus vulgaris L.

Common bean is an important legume that grown and consumed as animal feed and for human nutrition. It is also an important source of protein in developing countries. Transposable elements (TEs) constitute a large part of the genome in various eukaryotic species. TE was described as garbage DNA by researchers for a long time. Recently, it has been found that TEs can move near stress response genes and they have known effects on plant resistance to diverse stresses. With the acquisition of common bean genome sequence, one of the next step is to annotate the genome and define the functional DNA elements. TEs are the most abundant genetic elements of plant genomes and have an important impact on genome stress evolution and genetic variation. So, it is important to determine TEs in the common bean genome. In the current study, genome-wide transposon annotation and definition were achieved in root and leaf tissues of common bean under salt stress. Homology and sequence structure-based methods were used. Tont2-I-Copia and Copia-39 Copia retrotransposons were found to be more in salt-treated roots and leaves respectively. As a result of the analysis, we found TEs number ranging from 46 to 50 belonging to about twenty different plants. Gene ontology analysis of transposon sequences brought the light on diverse important pathways related to abiotic stress conditions.
Trends and Exceptions in the Interaction of Hydroxamic Acid Derivatives of Common Di- and Tripeptides with Some 3d and 4d Metal Ions in Aqueous Solution

By using various techniques (pH-potentiometry, UV-Visible spectrophotometry, 1H and 17O-NMR, EPR, ESI-MS), first time in the literature, solution equilibrium study has been performed on complexes of dipeptide and tripeptide hydroxamic acids—AlaAlaNHOH, AlaAlaN(Me)OH, AlaGlyGlyNHOH, and AlaGlyGlyN(Me)OH—with 4d metals: the essential Mo(VI) and two half-sandwich type cations, [(η6-p-cym)Ru(H2O)3]2+ as well as [(η5-Cp*)Rh(H2O)3]2+, the latter two having potential importance in cancer therapy. The tripeptide derivatives have also been studied with some biologically important 3d metals, such as Fe(III), Ni(II), Cu(II), and Zn(II), in order to compare these new results with the corresponding previously obtained ones on dipeptide hydroxamic acids. Based on the outcomes, the effects of the type of metal ions, the coordination number, the number and types of donor atoms, and their relative positions to each other on the complexation have been evaluated in the present work. We hope that these collected results might be used when a new peptide-based hydroxamic acid molecule is planned with some purpose, e.g., to develop a potential metalloenzyme inhibitor.
Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST-V and COAST-W)

Objectives To investigate the efficacy and safety of ixekizumab for up to 52 weeks in two phase 3 studies of patients with active radiographic axial spondyloarthritis (r-axSpA) who were biological disease-modifying antirheumatic drug (bDMARD)-naive (COAST-V) or tumour necrosis factor inhibitor (TNFi)-experienced (COAST-W). Methods Adults with active r-axSpA were randomised 1:1:1:1 (n=341) to 80 mg ixekizumab every 2 (IXE Q2W) or 4 weeks (IXE Q4W), placebo (PBO) or 40 mg adalimumab Q2W (ADA) in COAST-V and 1:1:1 (n=316) to IXE Q2W, IXE Q4W or PBO in COAST-W. At week 16, patients receiving ixekizumab continued their assigned treatment; patients receiving PBO or ADA were rerandomised 1:1 to IXE Q2W or IXE Q4W (PBO/IXE, ADA/IXE) through week 52. Results In COAST-V, Assessment of SpondyloArthritis international Society 40 (ASAS40) responses rates (intent-to-treat population, non-responder imputation) at weeks 16 and 52 were 48% and 53% (IXE Q4W); 52% and 51% (IXE Q2W); 36% and 51% (ADA/IXE); 19% and 47% (PBO/IXE). Corresponding ASAS40 response rates in COAST-W were 25% and 34% (IXE Q4W); 31% and 31% (IXE Q2W); 14% and 39% (PBO/IXE). Both ixekizumab regimens sustained improvements in disease activity, physical function, objective markers of inflammation, QoL, health status and overall function up to 52 weeks. Safety through 52 weeks of ixekizumab was consistent with safety through 16 weeks. Conclusion The significant efficacy demonstrated with ixekizumab at week 16 was sustained for up to 52 weeks in bDMARD-naive and TNFi-experienced patients. bDMARD-naive patients initially treated with ADA demonstrated further numerical improvements after switching to ixekizumab. Safety findings were consistent with the known safety profile of ixekizumab. Trial registration number NCT02696785/NCT02696798.
Childhood Traumatic Experiences and Post-Traumatic Stress Disorder in Female Adults: Which is the Role Played by Romantic Attachment?

Childhood traumatic experiences are known to have strong and durable effects on physical, mental and reproductive health. One of the most studied consequences of childhood trauma is the post-traumatic stress disorder (PTSD). The present study aims to investigate in a community sample of Italian female students: (1) the prevalence of PTSD; (2) the association between reported childhood traumatic experiences and the presence of PTSD in adulthood and the role played by the romantic attachment (anxiety, avoidance) on the relationship between childhood traumatic experiences and PTSD symptoms. Three hundred and twenty-seven female Italian students (mean age = 23.09 years; SD = 2.98) of the University of Padova participated in the study. Participants have been tested on childhood traumatic experiences (Childhood Trauma QuestionnaireShort Form, CTQ-SF); romantic attachment (Experience in Close Relationship-Revised, ECR-R) and post-traumatic stress disorder (Post-traumatic Stress Disorder Checklist for DSM-5, PCL-5). Results show that PTSD symptoms are significantly predicted by the experiences of emotional abuse and neglect. Moreover, anxiety and avoidance play a significant role in the relationship between the emotional forms of traumatic experiences and the current presence of PTSD symptoms. Clinical implications for the treatment of PTSD patients with history of interpersonal trauma are discussed.
Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse

Radiation therapy is an important and effective treatment option for prostate cancer, but high-risk patients are prone to relapse due to radioresistance of cancer cells. Molecular mechanisms that contribute to radioresistance are not fully understood. Novel computational strategies are needed to identify radioresistance driver genes from hundreds of gene copy number alterations. We developed a network-based approach based on lasso regression in combination with network propagation for the analysis of prostate cancer cell lines with acquired radioresistance to identify clinically relevant marker genes associated with radioresistance in prostate cancer patients. We analyzed established radioresistant cell lines of the prostate cancer cell lines DU145 and LNCaP and compared their gene copy number and expression profiles to their radiosensitive parental cells. We found that radioresistant DU145 showed much more gene copy number alterations than LNCaP and their gene expression profiles were highly cell line specific. We learned a genome-wide prostate cancer-specific gene regulatory network and quantified impacts of differentially expressed genes with directly underlying copy number alterations on known radioresistance marker genes. This revealed several potential driver candidates involved in the regulation of cancer-relevant processes. Importantly, we found that ten driver candidates from DU145 (ADAMTS9, AKR1B10, CXXC5, FST, FOXL1, GRPR, ITGA2, SOX17, STARD4, VGF) and four from LNCaP (FHL5, LYPLAL1, PAK7, TDRD6) were able to distinguish irradiated prostate cancer patients into early and late relapse groups. Moreover, in-depth in vitro validations for VGF (Neurosecretory protein VGF) showed that siRNA-mediated gene silencing increased the radiosensitivity of DU145 and LNCaP cells. Our computational approach enabled to predict novel radioresistance driver gene candidates. Additional preclinical and clinical studies are required to further validate the role of VGF and other candidate genes as potential biomarkers for the prediction of radiotherapy responses and as potential targets for radiosensitization of prostate cancer.
Influence of pH, temperature and glucose on biodegradation of 4-aminophenol by a novel bacterial strain, Pseudomonas sp. ST-4.

Aromatic compounds such as 4-aminophenol are toxic to the environment and thus should be eliminated effectively. Biodegradation of aromatic compounds is an efficient and environment friendly technique as addition of selected microbes does not add any kind of pollutants and actively remove even the most recalcitrant pollutants. We investigated the effectiveness of Pseudomonas sp. strain ST- 4 in the biodegradation of 4-aminophenol under variable pH, temperature and glucose regimes and sorted out optimum conditions for maximum biodegradation of 4-aminophenol. Maximum biodegradation of 4-aminophenol by Pseudomonas sp. strain ST- 4 was observed at pH 8, temperature 30°C and glucose concentration of 15 mM at 72 h, respectively.
The Practical Use of White Cell Inflammatory Biomarkers in Prediction of Postoperative Delirium after Cardiac Surgery

Introduction: Postoperative delirium (POD) is associated with unfavorable outcomes. It may result from neuroinflammation and oxidative stress. The aim of this study was to evaluate the role of routinely available inflammatory markers derived from white blood cell count (WBC), for prognostic value in diagnosing delirium after cardiac surgery. Methods: We performed an analysis of data collected from patients undergoing planned coronary artery bypass grafting (CABG). Differential WBC and CRP (C-reactive protein) concentration were evaluated preoperatively (T0) and postoperatively at day 1 (T1), 3 (T3), 5 (T5) after CABG. Differences in neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet-to-WBC ratio (PWR) between patients with (Del +) and without delirium (Del −) were evaluated. Patients were screened using CAM-ICU. Results: We included 968 patients in the study. Incidence of delirium was 13.3%. In the group with POD, the majority of patients were men (87/129, 67.44%), and the mean age was 72 years. Preoperative WBC (8.21 ± 3.04 G/l vs. 7.55 ± 1.86 G/l, p = 0.029) were higher and mean platelet count was lower (217.7 ± 69.07 G/l vs. 227.44 ± 59.31 G/l, p = 0.031) in patients with POD. Lower pre-operative PLR values (109.87 ± 46.38 vs. 120.36 ± 52.98, p = 0.026) and PWR values (27.69 ± 7.50 vs. 31.32 ± 9.88 p < 0.001) were found in patients with POD. Association was strongest for PWR and remained significant at T1 (p < 0.001), T3 (p < 0.001) and T5 (p < 0.001). Basing on coefficients of logistic regression a model for optimal prediction of POD was calculated: CARDEL Index (CARdiac DELirium Index) = 0.108 × Age + 0.341 × HBA1C − 0.049 × PWR with AUC of 0.742 (p < 0.001). Conclusions: The results of this study show that lower pre-operative levels of PLR and PWR were associated with POD after cardiac surgery. Pre-operative PWR showed strongest correlation with POD and may be a potential new biomarker associated with postoperative delirium. CARDEL prognosis index composed of age, HbA1c and PWR is good at predicting development of delirium after CABG.