Miracle-dz/UniFAR-FTUs huggingface dataset:
Factors Associated With Regorafenib Adherence With Metastatic Colorectal Cancer

Introduction Regorafenib is an oral multikinase inhibitor for the treatment of metastatic colorectal cancer (mCRC). The clinical factors that may affect adherence to regorafenib remain unclear. The aim of this study was to evaluate adherence to regorafenib with mCRC and to identify factors that might affect adherence to regorafenib. Methods A total of 108 consecutively enrolled Japanese patients with mCRC received regorafenib. Adherence was measured by pharmacists using pill counts and a self-reported treatment diary for patients at a pharmaceutical outpatient clinic. The median relative dose intensities of regorafenib and the factors adversely affecting adherence were retrospectively surveyed. Logistic regression analysis was then performed using patient socio-demographic factors and clinical factors. Results A total of 96 patients were included in the analysis. The median adherence rate was 61.7% in the first cycle. The median relative dose intensity was 57.1%. The most common reason for non-adherence was a hand-foot-skin reaction (35.6%). On multivariate analysis, increased non-adherence to regorafenib was significantly associated with sex (female) [odds ratio (OR) = 4.36; 95% confidence interval (CI): 1.43–13.22, p = 0.01]. Discussion Hand-foot-skin reactions and female sex were associated with lower adherence to regorafenib. Since these factors could be associated with lower adherence to regorafenib, it would be useful to consider these factors when assessing adherence.
Protective Effect of Green Tea Consumption on Colorectal Cancer Varies by Lifestyle Factors

The inconsistent findings regarding green tea intake and colorectal cancer (CRC) risk in several epidemiological studies might result from variations in lifestyle factors. Therefore, we examined whether increased green tea intake was associated with a decreased risk of CRC and how the risk of CRC was altered by the protective effect of green tea consumption and five health-related factors. A case-control study including 2742 participants (922 cases and 1820 controls) was conducted in Korea. Green tea consumption was assessed using a semiquantitative food frequency questionnaire. The risk of CRC was approximately 40% less in the participants in the highest green tea intake tertile than in participants in the lowest green tea intake tertile. Of the five lifestyle factors examined, high body mass index and physical inactivity were independent risk factors for CRC. Regarding the interactions between tea consumption and lifestyle factors, high green tea consumption was associated with a decreased risk of CRC, with or without considering lifestyle factors. However, moderate green tea consumption increased the risk of CRC among ever-smokers, ever-drinkers and the high-inflammatory diet group. Increased consumption of green tea might be helpful to reduce the risk of CRC in those with an unhealthy lifestyle.
A Chemometric Analysis of Deep-Sea Natural Products

Deep-sea natural products have been created by unique marine organisms that thrive in a challenging environment of extreme conditions for its inhabitants. In this study, 179 deep-sea natural products isolated from 2009 to 2013 were investigated by analysing their physicochemical properties that are important indicators of the ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) profile of a compound. The study and analysis of these molecular descriptors and characteristics enabled the defining of these compounds in various chemical spaces, particularly as an indication of their drug-likeness and position in chemical space and is the first to be conducted to analyse deep-sea derived natural products. It was found that ~40% of all deep-sea natural products were drug-like and 2/3 were within Known Drug Space (KDS), highlighting the high drug-likeness of a significant proportion of deep-sea natural products, most of which have already been shown to have notable biological activities, that should be further investigated as potential therapeutics. Furthermore, this study was able to reveal the general structural differences between compounds from Animalia, Bacteria and Fungi organisms where it was observed that natural products from members of the Animalia kingdom are structurally more varied than compounds from bacteria and fungi. It was also noted that, in general, fungi-derived compounds occupy a more favourable position in drug-like chemical space and are a rich and promising source of biologically-active natural products for the purposes of drug development and therapeutic application.
"The Contagion Effects of Financial Crisis on Stock Markets: What Can We Learn From a Cointegrated Vector Autoregressive Approach for Developed Countries? "

Abstract This research applies a set of diversified tests that have not been used on a joint basis to study the contagion effects of financial crises in the stock markets of developed countries. This is particularly important due to the fact that the existing literature has, so far, failed to adequately address the effects of financial crisis on such markets. Several empirical tests are performed on a joint basis: correlation tests; Kolmogorov-Smirnov tests; extreme value tests; and tests based on the estimation of Cointegrated Vector Autoregressive models. Significant evidence on the existence of contagion effects is provided with regards to the Asia crisis, the Russia crisis and the September 11 crisis. Finally, limited evidence is detected regarding the contagion effects on Brazil, Argentina and Mexico crisis. Resumen Esta investigacion aplica un conjunto de pruebas diversificadas que no se han utilizado en forma conjunta para estudiar los efectos de contagio de las crisis financieras en los mercados bursatiles de los paises desarrollados. Esto es particularmente importante debido al hecho de que en la literatura existente no se abordan adecuadamente los efectos de las crisis financieras en dichos mercados. Se realizan varias pruebas empiricas en forma conjunta: pruebas de correlacion; de Kolmogorov-Smirnov; de valor extremo; y las pruebas basadas en la estimacion de modelos de vectores autorregresivos cointegrados. Se muestra evidencia significativa de efectos de contagio durante la crisis asiatica, la crisis de Rusia y la crisis del 11 de Septiembre. Por ultimo, los efectos de contagio encontrados durante las crisis en Brasil, Argentina y Mexico son limitados.
Bacterial contamination of computer keyboards and Mice used in some banks in Benghazi, Libya

This study was performed to isolate and identify of bacterial contamination on the computer keyboards and mice surfaces in ten banks in Benghazi city-Libya. This study included collecting 300 samples, 30sample from each bank, from the surfaces of keyboards and mice, from all of the bacterial species in this study were identified by Biochemical tests, API test and Phoenix 100.Six pathogenic bacteria species have been identified: gram positive bacillus ,staphylococcus coagulase negative, E.coli, klebsillaoxytoca and Acinetobacter baumannii species was isolated only from the all banks. Most of the bacterial species dominate and which identify was Gram positive bacillus in all of the banks included in this study, on both from the surface of keyboard and mouse. This study showed that . the total percent of bacterial contamination was 97.35%. The percent of bacterial contamination of computers keyboards and mouse's respectively were 67.3% , 51% , 8.33% , 4.33% , and . 33% gram positive bacillus ,Staphylococcus coagulase negative, E.coli, Klebsillaoxytocaand Acinetobacter baumanniit these microorganisms have pathogenic potential and hence their presence on such surfaces (computer keyboards and mice) may be additional reservoirs for the transmission of microorganisms and become vector for cross-transmission of bacterial infection in the banks and its environment.
Increased Parasympathetic Activity by Foot Reflexology Massage after Repeated Sprint Test in Collegiate Football Players: A Randomised Controlled Trial

Foot reflexology massage (FRM) has positive effects on cardiovascular and haemodynamic functions. However, information regarding the physiological changes after FRM post exercise-stress is limited. This study investigated the acute effects of FRM on heart rate variability (HRV) after the repeated sprint ability (RSA) test and the Yo-Yo Intermittent Recovery Test Level 1 (YY). Twenty-six collegiate male football players were randomly assigned to the FRM group (n = 14) or to the control group (n = 12). Electrocardiographic (ECG) signals were recorded for 15 min in supine position before and after the intervention/control period in the RSA test and the YY test. In comparison to the control group, the FRM group demonstrated higher values of root mean squared successive difference in the RR interval (RMSSD; p = 0.046, ES = 0.76) and in the proportion of differences of adjacent RR intervals >50 ms (pNN50; p = 0.031, ES = 0.87); and higher percent changes in mean RR interval (%MeanRR; p = 0.040, ES = 0.99), standard deviation of RR intervals (%SDNN; p = 0.008, ES = 1.10), normalised high-frequency power (%nHFP; p = 0.008, ES = 0.77), total power (%TP; p = 0.009, ES = 0.84) and standard deviation 1 and 2 (%SD1; p = 0.008, ES = 1.08, %SD2; p = 0.020, ES = 1.04) after the RSA test. The magnitude effect of post-exercise HRV was small after the FRM RSA protocol (ES = 0.32–0.57). Conversely, the results demonstrated a moderate and large magnitude effect of HRV in the RSA and YY protocols of the control group (ES: RSA = 1.07–2.00; YY = 0.81–1.61) and in the YY protocol of the FRM group (ES = 0.99–1.59). The FRM intervention resulted in beneficial effects on the cardiac parasympathetic reactivity and the sympatho-vagal balance after RSA performance.
The Importance of Police Performance as a Determinant of Satisfaction with Police

Problem statement: Citizen satisfaction with police performance is an important concern of public managers because police performance is central to citizens and accounts for a large share of urban budgets. Also, there is substantial disagreement in the literature regarding determents of citizen satisfaction. Approach: Logistic regression was used to investigate the results of three public opinion surveys, conducted biannually, to identify determinants of citizen satisfaction with police. Results: The explanatory power of the models was indicated by concordance of over . 80. The findings indicated that satisfaction was largely determined by citizen perception of police behaviors. Four variables reflecting perceptions of police performance were particularly important: Response time to a crime in progress, visibility on the street, the quality of the relationship between the police and community and police efforts to reduce crime, indicating a chi square significance of <0.001. Almost all demographic and other individual factors, as well as subjective measures of crime severity in the respondent’s neighborhood were insignificant or less important. Conclusion/Recommendations: The findings suggested that public officials could improve citizen satisfaction by focusing on specific aspects of police behavior. Training programs should be oriented accordingly. Further research regarding how citizens interpret certain words, gestures, postures, or other behaviors by police promises to enhance satisfaction.
Viscometric Studies of Molecular Interactions in Binary Mixtures of Formamide with Alkanol at 298.15 and 308.15 K

Viscosity data were measured at 298.15 K and 308.15 K for formamide + 1-propanol, 2-propanol, 1-butanol, 2-methyl-1-propanol or 2-methyl-2-propanol mixtures. For an equimolar mixture, deviation in viscosity follows the sequence: 2-methyl-2-propanol >2-methyl-1-propanol>1-butanol>2-propanol>1-propanol. The viscosity data were further analyzed in terms of graph theory. Free energy of activation was also calculated from experimental viscosity data along with previously reported excess volume data. The deviation in viscosity and free energy of activation were fitted to Redlich-Kister polynomial equation. The viscosity data were also correlated by correlations like Grunberg-Nissan, Tamura-Kurata, Hind- McLaughlin-Ubbelohde, and Katti-Chaudhari relation. Various adjustable parameters, G 12 , T 12 , H 12 , and W vis /RT, of various correlations were used to predict viscosity deviation of binary mixtures. Positive value of G 12 indicates strong interaction in the studied systems. Grunberg-Nissan relation has lowest deviation among the four correlations for formamide + 1-propanol or 2-propanol mixtures; and for mixtures of formamide with 1-butanol or 2-methyl-1-propanol, Tamura- Kurata has lowest deviation. Grunberg-Nissan gives lowest deviation for formamide + 2-methyl-2-propanol mixtures.
Soil carbon and nitrogen stocks, light organic matter, and remaining phosphorus under a crop-livestock integration system

A integracao lavoura-pecuaria (ILP), combinada ao sistema plantio direto (SPD), e um sistema de manejo que tem sido desenvolvido para diversas condicoes edafoclimaticas, com muitas variacoes no Brasil, principalmente quanto a intensidade de pastejo. O objetivo deste estudo foi avaliar os efeitos de diferentes intensidades de pastejo e cultivo da soja (Glycine max L.) nos estoques de carbono (EstC) e nitrogenio (EstN), materia orgânica leve (MOL), conteudo de raizes na MOL (RMOL) e fosforo remanescente (Prem) em um Latossolo sob ILP. Os tratamentos consistiram em tres diferentes alturas de manejo do pasto na ILP (0,25 m [P25], 0,35 m [P35], e 0,45 m [P45]). Duas areas de controle, uma sem pastejo (SP) e uma area de vegetacao nativa de cerrado (cerradao) (CE), que estiveram adjacentes ao experimento, foram comparadas com as areas cultivadas. Em cada area as amostras foram coletadas nas camadas de 0,0-0,05; 0,05-0,10 e 0,10-0,20 m em delineamento inteiramente aleatorizado com 6 repeticoes. Os atributos do solo foram avaliados pos-ciclo de pastejo (PP) e pos-lavoura de soja (PL), que coincidiram com as estacoes seca e chuvosa, respectivamente. O CE apresentou maiores conteudos de MOL na camada 0,0-0,05 m na PL e na camada 0,05-0,10 m em ambas epocas PP e PL, C na MOL na camada 0,0-0,020 m durante o PP e a PL, N na MOL na camada 0,0-0,05 m na PL e na camada 0,05-0,10 m durante o PP e a PL, EstC na camada de 0,0-0,020 m em ambos PP e PL em relacao as areas cultivadas, entretanto menores valores de densidade do solo (Ds) e Prem na camada de 0,0-0,020 m durante o PP e a PL. O tratamento (P35) incrementou EstN na PL e RMOL no PP em relacao aos outros cultivos P25, P45 e SP. A ausencia de pastejo da area SP reduziu a Ds do PP para a PL, enquanto os tratamentos com diferentes intensidades de pastejo mantiveram estabilizados seus valores neste periodo. Os nossos resultados sugerem que a producao pode ser intensificada sob intensidades baixa e moderada de pastejo na ILP avaliada.
Effects of levothyroxine therapy on bone mineral density and bone turnover markers in premenopausal women with thyroid cancer after thyroidectomy.

INTRODUCTION We investigated the impact of long-term levothyroxine (LT4) treatment on bone mineral density (BMD) and bone turnover markers (BTMs) in premenopausal women with differentiated thyroid cancer (DTC) after thyroidectomy. MATERIAL AND METHODS 65 premenopausal women who received LT4 therapy at least 1 year after thyroidectomy for DTC and 50 premenopausal women without thyroid diseases were enrolled in this study. We measured the T-scores of lumbar and hip BMD, Serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), intact parathyroid hormone (iPTH), N-terminal propeptide of type 1 N procollagen (P1NP), C-terminal telopeptide of type 1 collagen (CTX-1), calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) in all participants. RESULTS In DTC subjects, serum TSH levels was lower, serum FT4, P1NP, CTX-1 and ALP levels were higher compared with controls. The prevalence of osteopenia was higher in DTC subjects than in controls. Multivariate logistic regression analysis showed that serum TSH levels were negatively associated with CTX-1 and ALP. CONCLUSIONS We found high prevalence of osteopenia among premenopausal women who received long-term LT4 therapy for DTC after thyroidectomy. Long-term TSH suppression therapy was an significant risk factor for decreased bone strength mainly by increasing bone turnover.
‘Having a Quiet Word’: Yarning with Aboriginal Women in the Pilbara Region of Western Australia about Mental Health and Mental Health Screening during the Perinatal Period

Despite high rates of perinatal depression and anxiety, little is known about how Aboriginal women in Australia experience these disorders and the acceptability of current clinical screening tools. In a 2014 study, the Kimberley Mum’s Mood Scale (KMMS) was validated as an acceptable perinatal depression and anxiety screening tool for Aboriginal women in the Kimberley region of Western Australia. In the current study, we explored if it was appropriate to trial and validate the KMMS with Aboriginal women in the Pilbara. Yarning as a methodology was used to guide interviews with 15 Aboriginal women in the Pilbara who had received maternal and child health care within the last three years. Data were analysed thematically, the results revealing that this cohort of participants shared similar experiences of stress and hardship during the perinatal period. Participants valued the KMMS for its narrative-based approach to screening that explored the individual’s risk and protective factors. While support for the KMMS was apparent, particular qualities of the administering health care professional were viewed as critical to the tool being well received and culturally safe. Building on these findings, we will work with our partner health services in the Pilbara to validate the KMMS with Pilbara Aboriginal women.
Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing

Spinocerebellar ataxia type 3 (SCA3) is a devastating neurodegenerative disease for which there is currently no cure, nor effective treatment strategy. One of nine polyglutamine disorders known to date, SCA3 is clinically heterogeneous and the main feature is progressive ataxia, which in turn affects speech, balance and gait of the affected individual. SCA3 is caused by an expanded polyglutamine tract in the ataxin-3 protein, resulting in conformational changes that lead to toxic gain of function. The expanded glutamine tract is located at the 5′ end of the penultimate exon (exon 10) of ATXN3 gene transcript. Other studies reported removal of the expanded glutamine tract using splice switching antisense oligonucleotides. Here, we describe improved efficiency in the removal of the toxic polyglutamine tract of ataxin-3 in vitro using phosphorodiamidate morpholino oligomers, when compared to antisense oligonucleotides composed of 2′-O-methyl modified bases on a phosphorothioate backbone. Significant downregulation of both the expanded and non-expanded protein was induced by the morpholino antisense oligomer, with a greater proportion of ataxin-3 protein missing the polyglutamine tract. With growing concerns over toxicity associated with long-term administration of phosphorothioate oligonucleotides, the use of a phosphorodiamidate morpholino oligomer may be preferable for clinical application. These results suggest that morpholino oligomers may provide greater therapeutic benefit for the treatment of spinocerebellar ataxia type 3, without toxic effects.
Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit

Background Studies of parents’ psychological well-being in single-family rooms in neonatal intensive care units have shown conflicting results. Aims To compare emotional distress in the form of depression, anxiety, stress and attachment scores among parents of very preterm infants cared for in a single-family rooms unit vs an open bay unit. Study design Prospective survey design. Subject Parents (132) of 77 infants born at 28 0/7–32 0/7 weeks of gestation in the two units. Outcome measures Duration of parental presence was recorded. Scores for depression (The Edinburgh Postnatal Depression Scale), anxiety (The State–Trait–Anxiety Inventory, Short Form Y), stress (The Parent Stressor Scale: neonatal intensive care unit questionnaire and The Parenting Stress Index—short form) and attachment (Maternal Postnatal Attachment Scale) measured 14 days after delivery, at discharge, expected term date and four months post-term. Results Parents were present 21 hours/day in the single-family room unit vs 7 hours/day in the Open bay unit. Ninety-three percent of the fathers in the single-family rooms unit were present more than 12 hours per day during the first week. Mothers in the single-family rooms had a significantly lower depression score -1.9 (95% CI: -3.6, -0.1) points from birth to four months corrected age compared to mothers in the Open bay unit, and 14% vs 52% scored above a cut-off point considered being at high risk for depression (p<0.005). Both mothers and fathers in the single-family rooms reported significantly lower stress levels during hospitalization. There were no differences between the groups for anxiety, stress or attachment scores after discharge. Conclusion The lower depression scores by the mothers and lower parental stress scores during hospitalization for both parents supports that single-family rooms care contribute to parents’ psychological wellbeing.
Does maternal stress influence winter survival of offspring in root voles Microtus oeconomus? A field experiment

Maternal stress can have long-term adverse consequences on immunocompetence and disease risk of offspring, and winter survival is a crucial demographic parameter in the life-history of an individual that can substantially affect northern rodent population dynamics. An understanding of the effects of maternal stress on winter survival of offspring may help identify mechanisms driving population fluctuations of northern small mammals. Thus, we assessed the effects of maternal stress, resulting from high population densities, on winter survival of first generation (F(1)) and second generation (F(2)) in root voles Microtus oeconomus. Replicate high- and low-density enclosed parental populations were established, from which we obtained F(1) generation that were used to establish new enclosed, equal-density populations. The adults of the high-density parental populations had higher corticosterone levels, an indication of physiological stress, than did those of the low-density parental populations. Over-winter survival of the F(1) generation voles from the low-density parental populations was greater than that of those from the high-density parental populations. Over-winter survival of F(2) generation voles did not differ between the two treatments. Our results suggest that maternal stress affected over-winter survival of first generations but not second generations. Reduced immunocompetence, resulting from high population density stresses, transferred to offspring may be a factor in annual (winter) population declines. Because the effect is transitory, i.e. immunocompetence of F(2) voles is not affected, reduced immunocompetence resulting from high density stresses would not contribute to lengthy periods of low population densities that are characteristic of multi-annual population fluctuations.