Miracle-dz/UniFAR-FTUs huggingface dataset:
The alopecias associated with vitamin D-dependent rickets type IIA and with hairless gene mutations: a comparative clinical, histologic, and immunohistochemical study.

OBJECTIVE To establish the unique and common clinical and microscopic characteristics of the alopecias associated with vitamin D-dependent rickets (VDDR) type IIA and with hairless gene mutations. DESIGN A comparative clinical, histologic, and immunohistochemical study of the alopecias in 6 patients with VDDR IIA and 4 patients with atrichia with papular lesions (APL) and/or alopecia universalis congenita (AUC) (hereinafter "APL/AUC"). MAIN OUTCOME MEASURES Clinical data were gathered from medical records, personal interviews, and physical examinations. Histologic and immunohistochemical studies were performed on 6 scalp punch biopsy specimens from each of the 2 studied groups. RESULTS The alopecias in VDDR IIA and APL/AUC showed similar clinical, histologic, and immunohistochemical features. The clinical presentation of the VDDR alopecia resembled either the APL phenotype (ie, with papules and milia) or the AUC phenotype (without papules and milia). The main histologic findings included void infundibula; absence of the lower two thirds of the hair follicles, often replaced by vertically oriented irregular epithelial structures or epithelial cysts; irregular epithelial structures, often with small cysts in the middle and lower dermis; and small, medium, and large keratinizing cysts at all levels of the dermis. The larger epithelial cysts in the upper dermis stained positively for cytokeratin (CK) 10, which suggests an infundibular derivation, whereas the remaining irregular epithelial structures and cysts in the middle and lower dermis stained positively most frequently for CK17, CK19, and CD34, which suggests an outer root sheath derivation. CONCLUSIONS The alopecias associated with VDDR IIA and with hairless gene mutations show striking clinical and microscopic similarities. Disintegration of the lower two thirds of the hair follicles seems to be the underlying defect, and a common pathogenetic pathway might be involved.
HYPERTENSION IN A PATIENT WITH ACRODERMATITIS ENTEROPATHICA

ABSTRACT. One patient with acrodermatitis enteropathica complicated by hypertension is presented. The pathogenesis of the markedly elevated blood pressure is unknown. The acrodermatitis healed completely on zinc therapy and parallel to this improvement the hypertension could easily be controlled with a gradually decreased antihypertensive drug dosage.
Motor Imagery Development in Primary School Children

Motor imagery provides a unique window on the integrity of movement representation. How this ability unfolds during development remains unknown, however. It was the aim of this cross-sectional study to chart the development of movement imagery over childhood using validated measures, and to examine its relationship to movement skill. A sample of 58 children aged 7–12 years were recruited from Australian primary schools. Motor imagery ability was assessed using the Radial Pointing Task and a (mental) Hand Rotation Task, whereas visual (or object-related) imagery was measured on a Letter Rotation Task. Motor skill was assessed on the McCarron Assessment of Neuromuscular Development (MAND). Results showed clear age differences on all measures: motor skill, motor imagery, and visual imagery. The relationship between motor imagery and motor skill was shown to become stronger with age, whereas no relationship between visual imagery and motor skill was evident at any age. Taken together, these results show that motor imagery has a distinct developmental trajectory that is entwined with the development of movement skill in children. We argue that movement imagery reflects the unfolding of internal modeling processes providing the foundation for adaptive, goal-directed movements.
Detecting driving fatigue with multimodal deep learning

Physiological signals such as EEG and EOG have been successfully applied to detect driving fatigue in single modality. In this paper, we propose a multimodal approach by combining partial EEG and forehead EOG to enhance driving fatigue detection. We investigate the key brain area where we collect the EEG to combine with forehead EOG. Our experiment results demonstrate that the temporal EEG signals from six-channel have the best performance when combining with forehead EOG to extract shared features. Furthermore, we propose a novel multimodal fusion strategy using deep autoencoder model to learn a better shared representation. We assess our approach with other fusion strategies on 21 subjects. Our multimodal approach achieves the best performance that the average COR and RMSE are 0.85 and 0.09, respectively. The experiment results demonstrate that our multimodal approach could learn an efficient shared representation between modalities and could significantly improve the performance of detecting driving fatigue.
Retinotopic and Lateralized Processing of Spatial Frequencies in Human Visual Cortex during Scene Categorization

Using large natural scenes filtered in spatial frequencies, we aimed to demonstrate that spatial frequency processing could not only be retinotopically mapped but could also be lateralized in both hemispheres. For this purpose, participants performed a categorization task using large black and white photographs of natural scenes (indoors vs. outdoors, with a visual angle of 24° × 18°) filtered in low spatial frequencies (LSF), high spatial frequencies (HSF), and nonfiltered scenes, in block-designed fMRI recording sessions. At the group level, the comparison between the spatial frequency content of scenes revealed first that, compared with HSF, LSF scene categorization elicited activation in the anterior half of the calcarine fissures linked to the peripheral visual field, whereas, compared with LSF, HSF scene categorization elicited activation in the posterior part of the occipital lobes, which are linked to the fovea, according to the retinotopic property of visual areas. At the individual level, functional activations projected on retinotopic maps revealed that LSF processing was mapped in the anterior part of V1, whereas HSF processing was mapped in the posterior and ventral part of V2, V3, and V4. Moreover, at the group level, direct interhemispheric comparisons performed on the same fMRI data highlighted a right-sided occipito-temporal predominance for LSF processing and a left-sided temporal cortex predominance for HSF processing, in accordance with hemispheric specialization theories. By using suitable method of analysis on the same data, our results enabled us to demonstrate for the first time that spatial frequencies processing is mapped retinotopically and lateralized in human occipital cortex.
Phase-translation group actions on strongly monotone skew-product semiflows

We establish a convergence property for pseudo-bounded forward orbits of strongly monotone skew-product semiflows with invariant phasetranslation group actions. The results are then applied to obtain global convergence of certain chemical reaction networks whose associated systems in reaction coordinates are monotone, as well as the dynamics of certain reactiondiffusion systems in time-recurrent structure including periodicity, almost periodicity and almost automorphy.
Oxidized LDL in Carotid Plaques and Plasma Associates With Plaque Instability

Objective—Oxidation of LDL plays a significant pathogenic role in atherosclerosis. In this study, we attempted to clarify the correlation between the morphology of human atherosclerotic plaques and the oxidized LDL (OxLDL) levels in plasma and carotid plaques. Methods and Results—OxLDL levels (ng/&mgr;g apolipoprotein B) in plasma and carotid plaques from 44 patients undergoing carotid endarterectomy and OxLDL levels in 17 control plasma and 9 normal intima samples were determined by a sandwich ELISA by using specific antibodies against OxLDL (DLH3) and apolipoprotein B. The plaques were immunohistochemically classified as macrophage (M&phgr;)-rich and M&phgr;-poor. In paired samples from individual patients, plaque OxLDL was nearly 70 times higher than plasma OxLDL (mean±SEM, 11.9±1.7 vs 0.18±0.01 ng/&mgr;g apoB, P <0.0001). The OxLDL level was significantly higher in M&phgr;-rich- than M&phgr;-poor plaques (19.6±2.8 vs 5.50±0.77ng/&mgr;g apoB, P <0.0001) and corresponded with DLH3 antigen positivity of the plaques. In patients with M&phgr;-rich plaques, plasma OxLDL was significantly higher than in the controls (0.20±0.02 vs 0.13±0.01ng/&mgr;g apoB, P =0.02). Conclusions—Our results suggest that LDL undergoes further oxidation in plaques, and that high plasma and plaque levels of OxLDL are correlated with the vulnerability to rupture of atherosclerotic lesions.
Influence of AC magnetic field amplitude on the surface magnetoimpedance tensor in amorphous wire with helical magnetic anisotropy

We have performed experimental and theoretical studies on the influence of ac magnetic field amplitude on the magnetoimpedance tensor in an amorphous wire with helical magnetic anisotropy. For the experimental measurements, we used an amorphous wire of composition (Co/sub 0.94/Fe/sub 0.06/)/sub 72.5/Si/sub 12.5/B/sub 15/ with negative, nearly zero magnetostriction constant, excited either by an ac circular h/sub /spl phi// or by an axial h/sub z/ magnetic field created by an ac electric current. We changed the ac current amplitude from 7.5 to 40 mA and the current frequency f from 1.5 to 20 MHz. The values of the asymmetric giant magnetoimpedance ratio associated with the sweeping direction of the dc field H/sub ex/ and the corresponding sensitivity were 211% and 0.64 V/Oe, respectively, for an ac current of 37.5 mA at 3 MHz. For the theoretical study based on the magnetization rotation, we obtained the second-order harmonic of the ac magnetization m/spl I.oarr//sup (2)/ induced by the relatively high ac magnetic field by solving the Landau-Lifshitz-Gilbert (LLG) equation. We also considered a second-order surface impedance tensor /spl sigmav//spl circ//sup (2)/, which allowed us to analyze quantitatively the influence of the ac magnetic field amplitude on the impedance tensor of the wire. We obtained the domain model of the wire with helical magnetic anisotropy having multidomains and the magnetization vector /spl plusmn/M/sub 0/ directed in the easy direction, and the corresponding static magnetic configurations, by solving the static LLG equation. For the given magnetic configurations, we calculated the second-order impedance tensor /spl sigmav//spl circ//sup (2)/. The results can well explain the irregular field characteristics of the voltage responses at low dc field value, when the wire was excited at high frequency and at large ac magnetic field.
Graphical message transmission using the monotonic vibration function of a smart phone

This study aimed at evaluating four vibrotactile capabilities for perceiving graphical information presented on a smart phone. Thirty-two blindfolded college students participated in four experiments to test their capabilities of two-point discrimination, relative and absolute judgments of line thickness, and recognition of basic shapes. All the information was received through the default vibration function of the phone, sensed by their scanning fingers. The results showed a good two-point discrimination accuracy rate, reaching 98.8% when the distance between two points was set at 3.2 mm; the relative judgment of line thickness reached the level of 78.3% accuracy when the two-line width difference ratio was set at 3%; the absolute judgment reached the level of 78.8% when the participants recognised line thickness from one of two. Overall, especially for the shapes judgment, the information transmitted by the various codes may be quite low. These findings should inspire advanced investigations and provide design guidelines. Practitioner Summary: This study tested four vibrotactile capabilities for perception of graphical information when solely using the monotonic vibration function of a smart phone. The results show low information transmission. These findings encourage advanced investigations of new coding systems so that relevant mobile applications could be developed to help the visually impaired.
Human Performance Factors in the Evaluation of Virtual Organizations

Performance evaluation is one of the most important issues that have been considered due to the transition from industrial age to knowledge era. Virtual organizations, as one of the challenges of third millennium, which came to existence for enhancing organization’s performance through outsourcing, are not excluding. The main objective of this paper is to investigate the main factors that affect the virtual organization performance and to show how these factors can be used in virtual organization evaluation.Based on review of literature, this study provides a conceptual model of important performance factors of virtual organization. This conceptual framework gives a valuable insight into the performance in virtual organization and can give a useful help to practitioners to evaluate the performance of these organizations. Then, we use expert opinion to validate proposed model and to rank the importance of the factors.
Labor Analgesia Consumption and Time to Neuraxial Catheter Placement in Women with a History of Surgical Correction for Scoliosis: A Case-Matched Study

BACKGROUND: Neuraxial analgesic techniques are the most effective form of labor analgesia. Small studies (9–21 patients), conducted 10 to 20 years ago, demonstrated successful neuraxial labor analgesia in only 50% to 66% of patients with surgical correction for scoliosis. Newer surgical techniques for scoliosis correction make the epidural space more accessible, but postsurgical changes may still alter the efficacy of neuraxial labor analgesia. The purpose of this prospective case-matched study was to compare hourly bupivacaine consumption and time to placement of neuraxial technique in laboring women with spinal instrumentation compared with women without previous back surgery. METHODS: All women with previous spinal instrumentation surgery for scoliosis correction who requested neuraxial labor analgesia at Prentice Women’s Hospital during the study period were approached. Control subjects were matched for anesthesiologist level of experience. The primary outcomes were bupivacaine consumption per hour of labor analgesia and time to placement of the neuraxial technique. Secondary outcomes included supplemental analgesia requirements and neuraxial analgesia failures and complications. RESULTS: Data from 41 women with surgical correction for scoliosis and 41 control subjects requesting neuraxial labor analgesia were analyzed. Obstetric and demographic characteristics of study participants were not different between groups. Median (interquartile range) hourly bupivacaine consumption was 15.2 mg/h (12.5–18.7) in the spinal instrumentation group and 14.2 mg/h (11.8–16.0) in the control group; the difference in medians was 1 mg/h (95% confidence interval [CI], −1.3 to 3.0; P = 0.38). The total bupivacaine consumption, number of manual reboluses, and number of subjects requiring greater bupivacaine concentrations did not differ between groups. Neuraxial analgesia failure occurred in 5 (12%) of women in the spinal instrumentation group but in none of the control patients (difference [95% CI], 12% [−0.3% to 25%]; P = 0.06). The mean time required to complete the neuraxial technique was 41% (95% CI, 7%–108%; P = 0.01) longer in the spinal instrumentation group than in the control group. The spinal instrumentation group also required a greater number of needle redirections, attempted interspaces, and need to switch to a more experienced provider than matched controls. CONCLUSIONS: The findings of this investigation suggest that previous surgery for scoliosis repair does not affect neuraxial labor analgesia consumption, but performance of the neuraxial technique is more difficult. Our findings suggest that neuraxial labor analgesia should be offered to parturients with previous surgery for scoliosis repair although informed consent should include a discussion of the possibility of technical difficulties and surgical anesthesia failure.
SarA level is a determinant of agr activation in Staphylococcus aureus

The control of virulence determinant expression in Staphylococcus aureus is a complex process involving global regulatory loci such as sar and agr. The sar locus consists of a 372 bp sarA open reading frame (ORF) preceded by a triple promoter region interspersed with two putative smaller ORFs (ORF3 and ORF4). The triple promoter system yields three overlapping sar transcripts (sarA, sarC and sarB of 0.56, 0.8 and 1.2 kb respectively). We have recently shown that the SarA protein binds to the agr promoter region to stimulate the transcription of RNAII and RNAIII, two major transcripts encoded within the agr locus. To assess the role of the region upstream of sarA in agr expression, we evaluated the contribution of ORF3 and ORF4 to SarA protein expression and to agr activation by introducing nonsense mutations into the respective ORFs. Northern analysis of sar mutant clones containing these mutations carried on a shuttle plasmid revealed that all three sar‐related transcripts are present. Using anti‐SarA monoclonal antibodies with defined epitopes in a competitive ELISA to determine the SarA protein level, we found that the introduction of a stop codon in ORF3 on a shuttle plasmid carrying the intact sar locus in a sar mutant led to a significant decrease in SarA protein level compared with the non‐mutated control. The effect of a nonsense mutation in ORF4 on SarA levels is much less. Likewise, an analogous sar mutant clone with a deletion in ORF3 also displayed a lower SarA level than its intact counterpart. The reduction in SarA expression correlated with a lower level of agr activation in the corresponding sar mutant clone. These data suggest that ORF3, and to a lesser degree ORF4, may affect agr expression by modulating SarA protein expression.
Cloacal papillomatosis in the absence of herpesvirus and papillomavirus in a sulphur-crested cockatoo (Cacatua galerita)

Abstract CASE HISTORY A 21-year-old male sulphur-crested cockatoo (Cacatua galerita) was presented following the sudden appearance of blood associated with the passage of faeces and urates. CLINICAL AND PATHOLOGICAL FINDINGS: There was fresh blood-staining of the feathers around the vent. The dorsal mucosal wall of the proctodeum was erythematous and roughened in appearance. An endoscopic biopsy was performed, and histological examination revealed multiple fronds of epithelium; the mucosa varied from simple to pseudostratified columnar epithelium, with diffuse hyperplasia of goblet cells. The underlying connective tissue stroma was well vascularised and was infiltrated with mixed inflammatory cells, comprising granulocytic cells and macrophages. PCR testing for both herpesvirus and papillomavirus, using consensus primers, was negative. DIAGNOSIS: Cloacal papillomatosis. CLINICAL RELEVANCE: This case manifested typical clinical signs and histological lesions of cloacal papillomatosis in the absence of demonstrable herpesvirus or papillomavirus. Veterinarians need to consider this disease in the differential diagnosis of blood in the droppings of parrots and cockatoos even in countries where psittacine herpesviruses are exotic diseases.
Sevoflurane Preconditioning Induces Neuroprotection Through Reactive Oxygen Species-Mediated Up-Regulation of Antioxidant Enzymes in Rats

BACKGROUND:It has been reported that sevoflurane preconditioning can induce neuroprotection, the mechanisms of which, however, are poorly elucidated. We designed the present study to examine the hypothesis that sevoflurane preconditioning could reduce cerebral ischemia– reperfusion injury through up-regulating antioxidant enzyme activities before ischemic injury by generating reactive oxygen species (ROS). METHODS:In preconditioning groups, adult male Sprague–Dawley rats were pretreated with 1 hour sevoflurane exposure at a dose of 1%, 2%, or 4% for 5 consecutive days. At 24 hours after the last exposure, all rats were subjected to focal brain ischemia induced by middle cerebral artery occlusion for 120 minutes followed by 72-hour reperfusion. The role of ROS in ischemic tolerance was assessed by administration of the free radical scavenger dimethylthiourea and antioxidant N-acetylcysteine before each preconditioning. Brain ischemic injury was evaluated by neurologic behavior scores and brain infarct volume calculation. Antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase [GSH-px]) of brain tissue and blood serum were tested at 24 hours after the last sevoflurane preconditioning. RESULTS:Sevoflurane preconditioning reduced infarct size and improved neurobehavioral outcome in a dose-dependent manner. The neuroprotective effects of sevoflurane preconditioning were abolished by dimethylthiourea and N-acetylcysteine. The activities of catalase and glutathione peroxidase (GSH-px) in the brain tissue were elevated by sevoflurane preconditioning before ischemic injury. The up-regulated activity of GSH-px in serum negatively correlated with brain infarct volume percentage. CONCLUSION:Sevoflurane preconditioning induces cerebral ischemic tolerance in a dose– response manner through ROS release and consequent up-regulation of antioxidant enzyme activity before ischemic injury in rats. Serum GSH-px activity could be developed as a marker to assess the effectiveness of sevoflurane preconditioning before ischemia.
Long-term effects of alpha-interferon therapy for type II mixed cryoglobulinemia.

BACKGROUND Several reports showed that mixed cryoglobulinemia (MC) is closely associated with hepatitis C virus (HCV) infection. Since several authors reported the efficacy of alpha-interferon in the treatment of MC, we investigated the long-term effects of this drug on clinical, hematological and virological parameters in a group of 18 patients (13 women and 5 men, mean age 56 +/- 11 years) affected by MC. METHODS A bone marrow biopsy was performed in all patients, and a liver biopsy was obtained in those with biochemical signs of chronic liver disease. The presence of HCV-RNA in serum was assessed by detection of anti-HCV antibodies and by PCR amplification of the 5' untranslated region of HCV. All patients followed the same treatment schedule: three million units of recombinant interferon alpha-2b s.c. , three times a week for 1 year. RESULTS In 5 cases bone marrow histology showed the presence of a monoclonal lymphocytic infiltrate. Liver biopsies were performed in 13 (72%) of the patients and a chronic liver disease was found in all 13. Anti-HCV antibodies were present in 17 (95%) subjects. HCV-RNA was detected in all cases (100%) before therapy. Five (28%) patients achieved a complete response and 9 (50%) a partial response, while the others (4 cases, 22%) showed minor responses. Four patients cleared the virus and obtained a complete remission of the MC. CONCLUSIONS HCV may be a cause of MC. The disease is associated with a high incidence of monoclonal lymphocytic infiltrate of the bone marrow. Alpha-interferon seems to be an effective agent for the treatment of MC.
On Universal Cycles for k-Subsets of an n-Set

A universal cycle, or Ucycle, for k-subsets of [n] = {1,. ,n} is a cyclic sequence of $(\stackerel{n}{k})$ integers with the property that each subset of [n] of size k appears exactly once consecutively in the sequence. Chung, Diaconis, and Graham have conjectured their existence for fixed k and large n when $n|(\stackerel{n}{k})$. Here the Ucycles for k=3, 4, 6, and large n relative prime to k are exhibited.