Miracle-dz/UniFAR-FTUs huggingface dataset:
RESOLVED MILLIMETER-WAVELENGTH OBSERVATIONS OF DEBRIS DISKS AROUND SOLAR-TYPE STARS

The presence of debris disks around young main-sequence stars hints at the existence and structure of planetary systems. Millimeter-wavelength observations probe large grains that trace the location of planetesimal belts. The Formation and Evolution of Planetary Systems Spitzer Legacy survey of nearby young solar analogues yielded a sample of five debris disk-hosting stars with millimeter flux suitable for interferometric follow-up. We present observations with the Submillimeter Array (SMA) and the Combined Array for Research in Millimeter-wave Astronomy at ∼2″ resolution that spatially resolve the debris disks around these nearby (d ∼ 50 pc) stars. Two of the five disks (HD 377, HD 8907) are spatially resolved for the first time and one (HD 104860) is resolved at millimeter wavelengths for the first time. We combine our new observations with archival SMA and Atacama Large Millimeter/Submillimeter Array data to enable a uniform analysis of the full five-object sample. We simultaneously model the broadband photometric data and resolved millimeter visibilities to constrain the dust temperatures and disk morphologies, and perform a Markov Chain Monte Carlo analysis to fit for basic structural parameters. We find that the radii and widths of the cold outer belts exhibit properties consistent with scaled-up versions of the Solar System's Kuiper Belt. All the disks exhibit characteristic grain sizes comparable to the blowout size, and all the resolved observations of emission from large dust grains are consistent with an axisymmetric dust distribution to within the uncertainties. These results are consistent with comparable studies carried out at infrared wavelengths.
Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics

We investigated the cell-death mechanisms induced in esophageal cancer cells in response to the chemotherapeutic drugs, 5-fluorouracil (5-FU) and cisplatin. Chemosensitive cell lines exhibited apoptosis whereas chemoresistant populations exhibited autophagy and a morphology resembling type II programmed cell death (PCD). Cell populations that respond with autophagy are more resistant and will recover following withdrawal of the chemotherapeutic agents. Specific inhibition of early autophagy induction with siRNA targeted to Beclin 1 and ATG7 significantly enhanced the effect of 5-FU and reduced the recovery of drug-treated cells. Pharmacological inhibitors of autophagy were evaluated for their ability to improve chemotherapeutic effect. The PtdIns 3-kinase inhibitor 3-methyladenine did not enhance the cytotoxicity of 5-FU. Disruption of lysosomal activity with bafilomycin A1 or chloroquine caused extensive vesicular accumulation but did not improve chemotherapeutic effect. These observations suggest that an autophagic response to chemotherapy is a survival mechanism that promotes chemoresistance and recovery and that selective inhibition of autophagy regulators has the potential to improve chemotherapeutic regimes. Currently available indirect inhibitors of autophagy are, however, ineffective at modulating chemosensitivity in these esophageal cancer cell lines.
Optimum Symptomatic Control of Parkinson's Disease with Dopaminergic Therapy

ABSTRACT: This paper presents a review of the literature on the therapeutic action and the side effects of the two main dopaminergic agents: L-DOPA/decarboxylase inhibitor (L-DOPA/DI) and bromocriptine (Parlodel ®) used either as monotherapy or in combination in patients with Parkinson's disease. The combination of L-DOPA/DI and bromocriptine gives the best therapeutic efficacy (49% improvement) in the total score (bradykinesia, rigidity and tremor). However, treatment by monotherapy or combination gives the same pattern of activity: greatest improvement in tremor, followed by rigidity and bradykinesia. Improvement observed in the short term is not sustained over longer periods of time for monotherapy with either drug. The short-term side effects are similar for each treatment, whereas long-term complications (dyskinesia, end-of-dose deterioration and on-off phenomenon) appear only when levodopa is used, alone (high incidence) or in combination with bromocriptine (low incidence). The overall optimum treatment is obtained with a combination of L-DOPA/DI and bromocriptine.
Subsurface Geometry of the San Andreas Fault in Southern California: Results from the Salton Seismic Imaging Project (SSIP) and Strong Ground Motion Expectations

The San Andreas fault (SAF) is one of the most studied strike‐slip faults in the world; yet its subsurface geometry is still uncertain in most locations. The Salton Seismic Imaging Project (SSIP) was undertaken to image the structure surrounding the SAF and also its subsurface geometry. We present SSIP studies at two locations in the Coachella Valley of the northern Salton trough. On our line 4, a fault‐crossing profile just north of the Salton Sea, sedimentary basin depth reaches 4 km southwest of the SAF. On our line 6, a fault‐crossing profile at the north end of the Coachella Valley, sedimentary basin depth is ∼2–3 km and centered on the central, most active trace of the SAF. Subsurface geometry of the SAF and nearby faults along these two lines is determined using a new method of seismic‐reflection imaging, combined with potential‐field studies and earthquakes. Below a 6–9 km depth range, the SAF dips ∼50°–60° NE, and above this depth range it dips more steeply. Nearby faults are also imaged in the upper 10 km, many of which dip steeply and project to mapped surface fault traces. These secondary faults may join the SAF at depths below about 10 km to form a flower‐like structure. In Appendix D, we show that rupture on a northeast‐dipping SAF, using a single plane that approximates the two dips seen in our study, produces shaking that differs from shaking calculated for the Great California ShakeOut, for which the southern SAF was modeled as vertical in most places: shorter‐period (T<1 s) shaking is increased locally by up to a factor of 2 on the hanging wall and is decreased locally by up to a factor of 2 on the footwall, compared to shaking calculated for a vertical fault.
Relation Between Sport and Spatial Imagery: Comparison of Three Groups of Participants

The literature suggests that sport may be considered a spatial activity and that engaging in spatial activities increases the capacity of an individual to implement mental imagery. Moreover, mental rotation calls upon motor processes that are heavily involved in sporting activities. For these reasons, the authors hypothesized that athletes ought to perform mental rotation tasks better than nonathletes. Also, athletes trained to react quickly to constantly changing environments should be faster at processing the information in a mental rotation task than athletes operating in more settled environments. The results of this study show that athletes performed the mental rotation task significantly faster than nonathletes. These results support the suggestion that there is a link between sport and the ability to perform mental image transformations; however, this ability may not be specific to the conditions in which the athlete performs.
Knowledge Networks: Explaining Effective Knowledge Sharing in Multiunit Companies

This paper introduces the concept of knowledge networks to explain why some business units are able to benefit from knowledge residing in other parts of the company while others are not. The core premise of this concept is that a proper understanding of effective interunit knowledge sharing in a multiunit firm requires a joint consideration of relatedness in knowledge content among business units and the network of lateral interunit relations that enables task units to access related knowledge. Results from a study of 120 new product development projects in 41 business units of a large multiunit electronics company showed that project teams obtained more existing knowledge from other units and completed their projects faster to the extent that they had short interunit network paths to units that possessed related knowledge. In contrast, neither network connections nor extent of related knowledge alone explained the amount of knowledge obtained and project completion time. The results also showed a contingent effect of having direct interunit relations in knowledge networks: While established direct relations mitigated problems of transferring noncodified knowledge, they were harmful when the knowledge to be transferred was codified, because they were less needed but still involved maintenance costs. These findings suggest that research on knowledge transfers and synergies in multiunit firms should pursue new perspectives that combine the concepts of network connections and relatedness in knowledge content.
Journal of Memory and Language

T gran Cie 000 Spa 776 the with reco sup stru S IDE A Sot Brit 1Z4 mation in the activation of spoken words. Listeners heard neutral sentences ending with word fragmen princi-) and made lexical decisions on letter strings presented at fragment offset. Responses were com fragment primes that fully matched the spoken form of the initial portion of target words, versus prime mismatched in a single element (stress pattern; one vowel; one consonant), versus control primes. Full ing primes always facilitated lexical decision responses, in comparison to the control condition, whil matching primes always produced inhibition. The respective strength of the contribution of stress, vow consonant (one feature mismatch or more) information did not differ statistically. The results support a of spoken-word recognition involving automatic activation of word forms and competition between act words, in which the activation process is sensitive to all acoustic information relevant to the language’s p ogy. © 2001 Academic Press
Asthma‐related SNP in FCER2 is associated with increased expression of IL‐4R on human B cells

A SNP (rs2228137) (R62W) in FCER2 has been linked with severe exacerbations in asthmatics. Transfectants expressing the SNP exhibited increased IL‐4Rα expression after stimulation through CD23 compared with wild‐type. Our data suggest that the SNP may favour increased IgE production through increased responsiveness to IL‐4 in patients possessing this genotype.
Establishment of Ionic Channels and Signalling Cascades in the Embryonic Stem Cell-Derived Primitive Endoderm and Cardiovascular System

The first organ system to be established in early embryogenesis is the cardiovascular system which develops upon interaction with hypoblastic cells of the primitive endoderm. Here we focus on recent work on embryoid bodies derived from pluripotent embryonic stem (ES) cells. Ca2+ oscillations and Ca2+ signalling pathways during the differentiation of primitive endodermal cell layers are reported. Furthermore, the development-dependent expression of ion channels and the buildup of signalling cascades involved in the modulation of voltage-dependent L-type Ca2+ channels during early cardiomyogenesis and the formation of functional vascular structures in the process of vasculogenesis and angiogenesis are reviewed. We also report on the use of green fluorescent protein reporter gene expression under the control of cardiac-specific promoters, e.g. the human cardiac α-actin promoter, which enables the identification and in vivo characterization of cardiomyocytes at very early stages of cardiomyogenesis.
Interspousal reliability of reports of marital violence.

Examined interpersonal reliability on reports of marital violence. 65 couples beginning marital therapy and 37 couples from the community participated. Husbands and wives had average ages of 35 and 32 yrs, respectively. Each S completed a version of the Conflict Tactics Scale on which they were asked to report on their own use of physically abusive behavior as well as their partner's use of such behaviors in the past 12 mo. Agreement between partners on the occurrence of violence was low to moderate for both the clinic and the community sample. Clinic husbands tended to underreport their own violent behavior, and/or clinic wives tended to overreport the violence performed by husbands. (7 ref) (PsycINFO Database Record (c) 2012 APA, all rights reserved)
Mechanisms for the generation and regulation of sequential behaviour

A critical aspect of much human behaviour is the generation and regulation of sequential activities. Such behaviour is seen in both naturalistic settings such as routine action and language production and laboratory tasks such as serial recall and many reaction time experiments. There are a variety of computational mechanisms that may support the generation and regulation of sequential behaviours, ranging from those underlying Turing machines to those employed by recurrent connectionist networks. This paper surveys a range of such mechanisms, together with a range of empirical phenomena related to human sequential behaviour. It is argued that the empirical phenomena pose difficulties for most sequencing mechanisms, but that converging evidence from behavioural flexibility, error data arising from when the system is stressed or when it is damaged following brain injury, and between-trial effects in reaction time tasks, point to a hybrid symbolic activation-based mechanism for the generation and regulation of sequential behaviour. Some implications of this view for the nature of mental computation are highlighted.
Pharmacokinetics of Sulfobutylether-Beta-Cyclodextrin and Voriconazole in Patients with End-Stage Renal Failure during Treatment with Two Hemodialysis Systems and Hemodiafiltration

ABSTRACT Sulfobutylether-beta-cyclodextrin (SBECD), a large cyclic oligosaccharide that is used to solubilize voriconazole (VRC) for intravenous administration, is eliminated mainly by renal excretion. The pharmacokinetics of SBECD and voriconazole in patients undergoing extracorporeal renal replacement therapies are not well defined. We performed a three-period randomized crossover study of 15 patients with end-stage renal failure during 6-hour treatment with Genius dialysis, standard hemodialysis, or hemodiafiltration using a high-flux polysulfone membrane. At the start of renal replacement therapy, the patients received a single 2-h infusion of voriconazole (4 mg per kg of body weight) solubilized with SBECD. SBECD, voriconazole, and voriconazole-N-oxide concentrations were quantified in plasma and dialysate samples by high-performance liquid chromatography (HPLC) and by HPLC coupled to tandem mass spectrometry (LC-MS-MS) and analyzed by noncompartmental methods. Nonparametric repeated-measures analysis of variance (ANOVA) was used to analyze differences between treatment phases. SBECD and voriconazole recoveries in dialysate samples were 67% and 10% of the administered doses. SBECD concentrations declined with a half-life ranging from 2.6 ± 0.6 h (Genius dialysis) to 2.4 ± 0.9 h (hemodialysis) and 2.0 ± 0.6 h (hemodiafiltration) (P < 0.01 for Genius dialysis versus hemodiafiltration). Prediction of steady-state conditions indicated that even with daily hemodialysis, SBECD will still exceed SBECD exposure of patients with normal renal function by a factor of 6.2. SBECD was effectively eliminated during 6 h of renal replacement therapy by all methods, using high-flux polysulfone membranes, whereas elimination of voriconazole was quantitatively insignificant. The SBECD half-life during renal replacement therapy was nearly normalized, but the average SBECD exposure during repeated administration is expected to be still increased.
A Lack of SUMO Conjugation Affects cNLS-dependent Nuclear Protein Import in Yeast*

Yeast SUMO (Smt3) and its mammalian ortholog SUMO-1 are ubiquitin-like proteins that can reversibly be conjugated to other proteins. Among the substrates for SUMO modification in vertebrates are RanGAP1 and RanBP2/Nup358, two proteins previously implicated in nucleocytoplasmic transport. Sumoylated RanGAP1 binds to the nuclear pore complex via RanBP2/Nup358, a giant nucleoporin, which was recently reported to act as a SUMO E3 ligase on some nuclear substrates. However, no direct evidence for a role of the SUMO system in nuclear transport has been obtained so far. By the use of conditional yeast mutants, we examined nuclear protein importin vivo. We show here that cNLS-dependent protein import is impaired in mutants with defective Ulp1 and Uba2, two enzymes involved in the SUMO conjugation reaction. In contrast, other transport pathways such as rgNLS-mediated protein import and mRNA export are not affected. Furthermore, we find that the yeast importin-α subunit Srp1 accumulates in the nucleus ofulp1 and uba2 strains but not the importin-β subunit Kap95, indicating that a lack of Srp1 export might impair cNLS import. In summary, our results provide evidence that SUMO modification in yeast, as has been suspected for vertebrates, plays an important role in nucleocytoplasmic trafficking.
Metal Artifact Reduction by the Alteration of Technical Factors in Multidetector Computed Tomography: A 3-Dimensional Quantitative Assessment

Objective: The purpose of this study was to examine the effects of computed tomographic (CT) parameters on metal artifact reduction in multidetector CT (MDCT) using a quantitative 3-dimensional (3D) measurement of the metal artifact volume. Methods: A steel-based plate and screw were implanted in the femora of 3 porcine thigh specimens. The specimens were examined using 16-slice MDCT with 7 different combinations of acquisition parameters that consisted of kilovolt (peak) (kV[p]) and effective milliampere-seconds (mAs): 120 and 100; 120 and 300; 120 and 500; 120 and 1000; 140 and 100; 140 and 300; and 140 and 500 under a detector collimation of 0.75 mm and a beam pitch of 0.45. The axial image reconstructions were performed with 4 different settings: 0.75-, 1-, 2-, and 2-mm slice thickness reconstruction under an extended CT scale. At the levels of all 14 screws in the 3 femora, the metal artifact volumes in various combinations of acquisition and reconstruction settings were measured using personal computer-based 3D imaging software and were compared with each other. Results: The presence of a metal artifact was significantly reduced by increasing the kilovoltage and by decreasing the reconstruction thickness (P < 0.05; 2-way analysis of variance test). Neither increasing the effective mAs nor applying extended CT scale reduced the presence of the metal artifact significantly (P = 0.599 and P = 0.474, respectively). Compared with the metal artifact volume at 120 kV(p) and 100 mAs and a 2-mm slice thickness as a reference setting, the metal artifact reduction rate was 22% by increasing kilovoltage to 140, whereas only 11% by increasing mAs to 1000. Conclusions: We could quantitatively measure the metal artifact volume in MDCT by using 3D imaging software. In practice, the results of our study indicate that increasing kilovoltage is more effective for metal artifact reduction than increasing the effective mAs.
The effect of iron status of Nigerien mothers on that of their infants at birth and 6 months, and on the concentration of Fe in breast milk

1. Within the limits of this study, neither maternal iron deficiency nor Fe-overload as measured at term appeared to affect the complement of Fe received by the foetus. 2. Infants feeding entirely on breast milk appeared to have normal Fe status 6 months postpartum regardless of the Fe status of the mother. 3. No relationship could be demonstrated between the Fe content of breast milk and the Fe status of the mother.
Timing of surgery in cauda equina syndrome with urinary retention: meta-analysis of observational studies.

OBJECT The authors performed exploratory meta-analyses of observational cohort studies, evidence level III, examining whether earlier surgery makes a difference in outcome in terms of urinary function once cauda equina syndrome (CES) from a herniated lumbar disc has progressed to urinary retention (CESR). METHODS Literature search identified 27 studies of CESR patients with clear definition of surgical timing. Relative risk (RR) could not be calculated in 11 studies, leaving 16 for meta-analysis. Urinary retention related to surgical timing at 5 breakpoints: 12, 24, 36, 48, or 72 hours. Urinary outcome was classified as Normal, Fair, or Poor. Meta-analysis was performed for "Event = Fair/Poor" or "Event = Poor. " Eight studies allowed separation into CESR and incomplete CES (CESI), and 5 of these had enough data for meta-analysis to compare CESR and CESI. A random effects meta-analysis model was used because of heterogeneity across the studies. A best-evidence synthesis was performed for the 4 largest studies that had 24- and 48-hour breakpoints. RESULTS For "Event = Fair/Poor," meta-analyses using the 5 breakpoints predicted a more likely Fair/Poor outcome for later surgery (RR range 1.77-2.19). The RR for later timing of surgery was statistically significant for 24-and 72-hour breakpoints and was elevated but not statistically significant for the other 3. For "Event = Poor," the RR range was 1.09-5.82, statistically significant for the 36 hour breakpoint only. Meta-analysis comparing CESR patients with CESI patients predicted a Fair/Poor result for CESR (RR 2.58, 95% confidence interval 0.59-11.31). The best-evidence synthesis did not disclose reasons for differences in the results of the 4 studies. CONCLUSIONS This study supports early surgery for CES and indicates that CESR and CESI cases should not be analyzed together.
Platelet activation and apoptosis are different phenomena: evidence from the sequential dynamics and the magnitude of responses during platelet storage

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Recruitment of Older Women: Lessons Learned From the Baltimore Hip Studies

ObjectivesThis study used a qualitative approach in which participants were asked to write about their experiences in recruiting older women into either one of two exercise intervention studies that are part of the Baltimore Hip Studies. The sample included 8 researcher nurses all women, White, and 42–53 years of age. BackgroundOlder adults, particularly older women, are less likely to participate in research studies when compared to their younger counterparts. The purpose of this study was to explore the techniques successfully used by research nurses in the Baltimore Hip Studies to recruit older women after hip fracture into exercise intervention studies. MethodData analysis was performed using basic content analysis (Crabtree & Miller, 1992; Miles & Huberman, 1984) “in vivo” coding (Dowd, 1991), or “grounded” coding (Glaser & Strauss, 1967), which involves using the informants’ own words to capture a particular idea. ResultsA total of 16 codes were identified and reduced to nine themes. Seven themes focused on techniques that facilitated recruitment: (a) caring for individuals; (b) emphasizing benefits; (c) eliciting support from others; (d) being an expert; (e) using role models; (f) using good timing; and (g) giving good first impressions. The remaining two themes identified barriers to recruitment: (a) time commitment and (b) lack of support. DiscussionBased on these themes, specific recruitment techniques are recommended. Ongoing research, however, is needed to establish the most effective recruitment procedures with older women.