Miracle-dz/UniFAR-FTUs huggingface dataset:
Fixed-dose combination ezetimibe + atorvastatin lowers LDL-C equivalent to coadministered components in randomized trials : use of a dose response model Running title : LDL-C lowering efficacy of fixed-dose combination ezetimibe + atorvastatin therapy

Coadminstration of ezetimibe with atorvastatin is a generally well-tolerated treatment option that reduces LDL-C levels and improves other lipids with greater efficacy than doubling the atorvastatin dose. The objective of the study is to demonstrate the equivalent lipid-modifying efficacy of fixed-dose combination (FDC) ezetimibe/atorvastatin compared with the component agents coadministered individually in support of regulatory filing. Two randomized, 6-week, double-blind crossover trials, compared the lipid-modifying efficacy of ezetimibe/atorvastatin 10/20mg (n=353) or 10/40mg (n=280) versus separate coadministration of ezetimibe 10mg plus atorvastatin 20mg (n=346) or 40mg (n=280), A cc ep te d A rt ic le This article is protected by copyright. All rights reserved. respectively in hypercholesterolemic patients. Percent changes from baseline in LDL-C (primary endpoint) and other lipids (secondary endpoints) were assessed by analysis of covariance; triglycerides were evaluated by longitudinal-data analysis. Expected differences between FDC and the corresponding coadministered doses were predicted from a doseresponse relationship model; sample size was estimated given the expected difference and equivalence margins (±4%). LDL-C-lowering equivalence was based on 97.5% expandedconfidence intervals (CI) for the difference contained within the margins; equivalence margins for other lipids were not prespecified. Ezetimibe/atorvastatin FDC 10/20mg was equivalent to coadministered ezetimibe+atorvastatin 20mg in reducing LDL-C levels (54.0% vs 53.8%) as was FDC 10/40mg and ezetimibe+atorvastatin 40mg (58.9% vs 58.7%), as predicted by the model. Changes in other lipids were consistent with equivalence (97.5% expanded-CIs <±3%, included 0); triglyceride changes varied more. All treatments were generally well-tolerated. Hypercholesterolemic patients administered ezetimibe/atorvastatin 10/20 and 10/40mg FDC had equivalent LDL-C lowering. This FDC formulation proved to be an efficacious and generally well-tolerated lipid-lowering therapy. (Clinicaltrials.gov: NCT01370590 and NCT01370603)
Placement of a Disproportionate Number of Minority Students in Special Education

This edition of the newsletter of the National Information Center for Handicapped Children and Youth is intended to help special educators and human service professionals improve the availability of services to handicapped children from minority groups. The first part of the paper focuses on current trends including: (1) the increase in the number of minority children attending U.S. schools; (2) the persistence of poverty in minority communities; (3) the vulnerability of minority children to developing disabilities early in life; and (4) the placement of disproportionate numbers of minority children in special education classes. The second section makes specific suggestions for increasing the number of special education teachers from minority groups; for increasing the sensitivity of special educators to minority concerns, anC for enhancing the effectiveness of outreach to minority communities.
Validation of PCR-Based Assays and Laboratory Accreditation for Environmental Detection of Aquatic Invasive Species

This white paper was developed by the members of isac and discusses the need for developing validation requirements for Polymerase Chain Reaction (pcr) and other dna-based molecular assays that are increasingly being used to detect ais. It does not provide a simplified checklist for evaluation of their ability to detect ais. Rather, it is intended to demonstrate the need for a required and regulated framework to validate these molecular assays. A regulated framework for validation would greatly increase confidence in the utility of dna-based assays and better enable decision-makers and managers regarding ais detection, prevention, monitoring and control.
linical Surgery-American pithelioid sarcoma : the University of Washington xperience atrick

BACKGROUND: Epithelioid sarcoma is a rare sarcoma with a high local recurrence rate that frequently metastasizes to lymph nodes. We reviewed our experience with adjuvant therapy in patients with this disease. METHODS: Between 1990 and 2003, we treated 11 patients with epithelioid sarcoma. Patient, tumor, and treatment characteristics were analyzed, and effect of treatment on survival was evaluated by the Kaplan-Meier method. RESULTS: Nine men and 2 women were treated. Tumors presented on the trunk, the upper extremities, and the lower extremities. Five patients developed nodal disease. All patients underwent surgery for the primary tumor, and 7 patients had nodal evaluation. Ten patients underwent adjuvant chemotherapy, and 9 underwent radiotherapy. Recurrence developed in 9 patients. Five-year diseasefree and overall survival rates were 46% and 65%, respectively. Chemotherapy and radiation therapy did not impact disease-free survival. CONCLUSIONS: Although surgery remains the primary treatment modality, multi-institutional trials are needed to develop more effective adjuvant therapy for patients with epithelioid sarcoma. © 2008 Elsevier Inc. All rights reserved.
FIXED POINTS OF CONTRACTIVE DOMINATED MAPPINGS IN AN ORDERED QUASI-PARTIAL METRIC

Fixed points results of mappings satisfying certain contractive conditions on the entire domain has been at the centre of vigorous research activity and it has a vide range of applications in different areas such as nonlinear and adoptive control systems, parameterize estimation problems, fractal image decoding, computing magnetostatic fields in a nonlinear medium, and convergence of recurrent networks, (see [16, 18, 27]). Recently, many results appeared related to fixed point theorem in complete metric spaces endowed with a partial ordering in literature. Ran and Reurings [23] proved an analogue of Banach’s fixed point theorem in metric space endowed with a partial order and gave applications to matrix equations. In this
Pore-Scale Imaging of the Oil Cluster Dynamic during Drainage and Imbibition Using In Situ X-Ray Microtomography

We imaged water-wet and oil-wet sandstones under two-phase flow conditions for different flooding states by means of X-ray computed microtomography (μCT) with a spatial resolution of 2.1 μm/pixel. We systematically study pore-scale trapping of the nonwetting phase as well as size and distribution of its connected clusters and disconnected globules. We found a lower , 19.8%, for the oil-wet plug than for water-wet plug (25.2%). Approximate power-law distributions of the water and oil cluster sizes were observed in the pore space. Besides, the value of the wetting phase gradually decreased and the nonwetting phase gradually increased during the core-flood experiment. The remaining oil has been divided into five categories; we explored the pore fluid occupancies and studied size and distribution of the five types of trapped oil clusters during different drainage stage. The result shows that only the relative volume of the clustered oil is reduced, and the other four types of remaining oil all increased. Pore structure, wettability, and its connectivity have a significant effect on the trapped oil distribution. In the water sandstone, the trapped oil tends to occupy the center of the larger pores during the water imbibition process, leading to a stable specific surface area and a gradually decreasing oil capillary pressure. Meanwhile, in oil-wet sandstone, the trapped oil blobs that tend to occupy the pores corner and attach to the walls of the pores have a large specific surface area, and the change of the oil capillary pressure was not obvious. These results have revealed the well-known complexity of multiphase flow in rocks and preliminarily show the pore-level displacement physics of the process.
SFB 823 Heterogeneity in residential electricity consumption : A quantile regression approach

Reducing household electricity consumption is of central relevance to climate policy given the share of 12.2% of the residential sector in greenhouse gas emissions. Drawing on data originating from the German Residential Energy Survey (GRECS), this paper estimates the contribution of individual appliances to household electricity demand using the conditional demand approach, which relies on readily obtainable information on appliance ownership. Moving beyond the standard focus of mean regression, we employ a quantile regression approach to capture the heterogeneity in the contribution of each appliance according to the conditional distribution of household electricity consumption. This heterogeneity indicates that there are quite large technical potentials for efficiency improvements and electricity conservation in private households. We also find substantial differences in the end-use shares across households originating from the opposite tails of the electricity consumption distribution, highlighting the added value of applying quantile regression methods in estimating consumption rates of electric appliances. JEL classification: D12, Q41.
METRIZABILITY OF RECTIFIABLE SPACES

A topological space G is said to be a rectiable space provided that there are a surjective homeomorphism φ : G × G → G × G and an element e ∈ G such that π1 ◦ φ = π1 and for every x ∈ G we have φ(x, x) = (x, e), where π1 : G × G → G is the projection to the rst coordinate. In this paper, we rstly show that every submaximal rectiable space G either has a regular G -diagonal, or is a P-space. Then, we mainly discuss rectiable spaces are determined by a point-countable cover, and show that if G is an α4-rectiable space determined by a point-countable cover G consisting of bisequential subspaces then it is metrizable, which generalizes a result of Lin and Shen's.
Reproduction of the Red-Bellied Pademelon Thylogale billardierii (Marsupialia)

'Thylogale billardierii, which is abundant in Tasmania, is a seasonal breeder with most births in the months April, May and June. Parturition is followed by mating, and the zygote so produced remains dormant until either sucking becomes intermittent near the end of pouch life or the young is lost. The mean length of the oestrous cycle was determined at 30.3 days, not significantly longer than the duration of gestation (30.2 days). Removal of pouch young results in the birth of a new young 28.7 days later. Removal of the corpus luteum results in oestrus 11 days later. Pouch life is 202 days, and vacation of the pouch by the young coincides precisely with parturition and post-partum mating. The young mature at about 14-15 months.
Nanoplankton fraction in the phytoplankton structure in the southern Gulf of Mexico (April 2000) Fracción de nanoplancton en la estructura del fitoplancton en el sur del Golfo de México (abril de 2000)

Phytoplankton, especially the nanoplankton fraction, and its possible relationships with the hydrographic conditions in the southern Gulf of Mexico were studied during an oceanographic cruise in April 2000. Hydrographic data and phytoplankton were analyzed. Phytoplankton species composition showed heterogeneity among stations. A total of 180 species were found: 114 diatoms, 32 dinoflagellates, 32 coccolithophores, and 2 silicoflagellates. Diversity indices were variable (0.96–5.12 bits ind –1 ). Phytoplankton was numerically dominated by coccolithophores or nanoplanktonic diatoms. Cell abundance was low to moderately high, ranging from 5.3 × 10 3 to 1.4 × 10 5 cells L –1 . The most abundant, dominant species were nanoplanktonic forms: two coccolithophores, Emiliania huxleyi and Gephyrocapsa oceanica; the pennate diatoms Nitzschia bicapitata, N. bifurcata and N. leehyi; and centric diatoms of the genus Thalassiosira. The high subsurface abundance of coccolithophores at two stations was related to a thermal front in the Grijalva-Usumacinta river system.
Computational Studies of the Hydroxyapatite Nanostructures , Peculiarities and Properties

In this review paper the main approaches to modeling the hydroxyapatite (HAP) structures and first-principle calculations of their properties, pure and with various defects, are considered. First, the HAP nano-particles (NPs) and clusters peculiarities are described using different methods: molecular mechanical and quantum mechanical, especially semi-empirical such as PM3. Both approximations used here, namely, restricted Hartee-Fock (RHF) and unrestricted Hartee-Fock (UHF), are considered. The influence of the protons (hydrogens), contained in the surrounding medium (pH), on the formation of HAP nanoparticles of various sizes and shapes is considered and discussed. Second, the HAP crystal unit cells studies are considered on the basis of a density functional theory (DFT) modelling. The main peculiarities of both phases (hexagonal and monoclinic) are considered too, including their ordered and disordered substructures. One of the important aspects of the computer modeling of HAP is to build the models and consider various structural modifications of HAP (such as, vacancies of oxygen atoms and hydroxyl OH group, hydrogen interstitials and different substitutions of atoms in HAP unit cell), which allow explicitly creating and exploring the changes in the charges of HAP and the electrical potential on the HAP surface. HAP modifications are most close to biological HAP and therefore are necessary for implant medical applications and can create and functionalize HAP surface with most adhesive properties for living cells (osteoblasts, osteoclatst). This improves the HAP implant quality. Besides, it has recently been established that oxygen vacancy in HAP influences their photo-catalytic properties. It is important for HAP usage as in environmental remediation and for bacteria inactivation. Therefore it is very important to create and investigate the oxygen vacancy models in HAP, and others defects models. In this work we review a DFT modelling and studies of HAP, both pure perfect bulk and imperfect bulk cases. Special HAP modelling approaches are used for layered slab super-cells units, which include vacuum spaces between the layered slabs forming HAP surface. To all these computer studies the first principle calculations were applied. In this review various DFT approximations are analysed for bulk and surface modified HAP. These approximations are carried out using both the local basis (local density approximation – LDA, in AIMPRO codes) and the plane-waves (generalized gradient approximation – GGA, in VASP codes). Data of all structures and models of HAP defects investigated are widely analyzed.
How Fat‐Tailed is US Output Growth?

Several studies have recently rejected the common hypothesis that aggregate output is normally distributed. The present paper reconsiders this issue for US output growth. To this end, it focusses on the shape parameter b of the exponential power distribution (EPD), the two polar values of which constitute the normal distribution and the Laplace distribution with its fatter tails, respectively. The paper first warns against premature conclusions that neglect a structural break in output volatility. On the basis of a battery of Monte Carlo experiments, it is then found out that the results strongly depend on which subperiod is considered, the Great Inflation (GI) or the Great Moderation (GM) period, and which data are referred to, the growth rates of GDP, firm sector output, and quarterly or monthly industrial production (IP). Here, only quarterly IP can be said to exhibit fat tails in GI as well as GM; other evidence is mixed.
Clinical Phenotype of De Novo GNAO1 Mutation

Mutations in the guanine nucleotide-binding protein (G protein), α activating activity polypeptide O (GNAO1) gene have recently been described in 6 patients with early infantile epileptic encephalopathies. In the present study, we report the phenotype and the clinical course of a 4-year-old female with an epileptic encephalopathy (Ohtahara syndrome) and profound intellectual disability due to a de novo GNAO1 mutation (c.692A>G; p.Tyr231Cys). Ohtahara syndrome is a devastating early infantile epileptic encephalopathy that can be caused by mutations in different genes, now also including GNAO1. The mutation was found using a targeted next generation sequencing gene panel and demonstrates targeted sequencing as a powerful tool for identifying mutations in genes where only a few de novo mutations have been identified.
Neotropical termite species (Isoptera) richness declining as resource amount rises : Food or enemy-free space constraints?

Understanding the way resource amount relates to species richness, and its underlyingmechanisms, may help to unveil the role played by species demands and species interactions on ecosystem functioning and, hence, how biodiversity is regulated. With this in mind, we investigated the effects of increasing resource amount on termite species richness at a local scale, in a remnant of Brazilian Atlantic Rain Forest. Starting from a statistical model comprised by litter biomass, volume of fallen logs, and soil's clay content, we found a minimal adequate model revealing a negative relationship between termite species richness and litter biomass. Three hypotheses could explain such a negative relationship: as litter amount increased species numbers diminished because (i) another resource diminished; (ii) colonies retracted their foraging range, impairing sampling detection and hence producing pseudo-decrements in diversity; or (iii) predation risk increased. Hypotheses (i) and (ii) lack support because soil's clay content did not relate either to species richness nor to abundance, despite the fact that most termites recorded belonged to the soil-feeding guild. We argue in favor of hypothesis (iii), specially considering that ants -the main predators of termites- have been already reported to relate positively to litter amount in this environment.
single nucleotide resolution during vertebrate embryogenesis Dynamic regulation of the transcription initiation landscape at Material Supplemental

Material Supplemental http://genome.cshlp. org/content/suppl/2013/09/24/gr.153692. 112.DC1. html References http://genome.cshlp. org/content/23/11/1938.full. html#ref-list-1 This article cites 58 articles, 22 of which can be accessed free at: License Commons Creative . http://creativecommons.org/licenses/by-nc/3.0/ described at a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as ). After six months, it is available under http://genome.cshlp. org/site/misc/terms.xhtml first six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the
Downside beta and the cross-sectional determinants of listed property trust returns

Executive Summary. This study examines the importance of downside beta when seeking to explain variations in listed property trust (LPT) returns in Australia between 1993 and 2005. The results reveal that downside beta outperforms conventional beta and provides higher explanatory power to the cross-sectional LPT return variations. The results also indicate that investors only require a premium for downside risk. However, the explanatory power of downside beta has diminished once the co-kurtosis of LPTs is controlled. Interestingly, the results also reveal that by itself downside beta is unable to fully explain returns in line with strong evidence for momentum and book-to-market ratio. The findings provide additional insights for investors and real estate analysts into the pricing of LPTs.
APPENDIX A : Semistructured Interview Guide : Family-Based Treatment for Children and Adolescents with Anorexia Nervosa Introduction

Method: Fundamental qualitative description guided the sampling and data collection in this study. A purposeful sample of 40 therapists providing treatment to youth with AN, completed an in-depth interview. Conventional content analysis guided the development of initial codes and categories, whereas constant comparison analytic techniques were used to compare and contrast therapist perceptions across contexts. Summative content analysis was used to provide counts of keywords, phrases, and themes.
Willebrand factor resulting in adhesion of platelets to the site of injury

Significance: Reactive oxidant species (ROS) are highly reactive molecules produced by several cell lines including platelets and serve as second messenger for intracellular signaling. In recent years it became evident that ROS are also implicated in the thrombotic process. Statins are lipid lowering molecules which reduce serum cholesterol and retard atherosclerotic complication and its clinical sequelae. However there is evidence that statins may exert an antiplatelet effects by interfering with redox signaling. Recent Advances: Experimental and clinical studies provided evidence that intra-platelet ROS formation is implicated in the process of thrombosis, as impaired ROS neutralization is associated with serious thrombotic complication and eventually death. Recent studies demonstrated that statins possess antiplatelet activity via inhibition of platelet NADPH oxidase–derived ROS formation. This effect results in down-regulation of isoprostanes, which are pro-aggregating molecules, and up-regulation of nitric oxide, which is a platelet inhibitor; such changes occurred immediately after statin’s administration and were independent from lipid lowering property. Critical Issues: Experimental and clinical studies documented that statins possess an antithrombotic effects which may account for thrombotic-related vascular outcomes. This has been evidenced in clinical settings such as percutaneous coronary intervention, myocardial infarction and venous thrombosis. It is still unclear, however, if the statin’s antithrombotic effect is dose-related. Future Directions: Future studies should be addressed to analyse if the antiplatelet effect of statins may preferentially occur at high dosage of statins. Furthermore, the antiplatelet effects of statins could turn useful in clinical settings where the clinical efficacy of aspirin and other antiplatelet drugs are still uncertain. Antioxid. Redox Signal. 00, 000–000.
Local Organizing Committee

s of Talks . 21 Poster Abstracts . 69 Index of Authors . 161 Directory of Participants . 172 Late Participants . 186
Regression Linear Loss : MSE Convolutional Neural Network Convolutional Activation Maps for Pie Chart Convolutional Activation Maps for Bar Chart Results

Convolutional neural networks can successfully perform many computer vision tasks on images. For visualization, how do CNNs perform when applied to graphical perception tasks? We investigate this question by reproducing Cleveland and McGill’s seminal 1984 experiments, which measured human perception efficiency of different visual encodings and defined elementary perceptual tasks for visualization. We measure the graphical perceptual capabilities of four network architectures on five different visualization tasks and compare to existing and new human performance baselines. While under limited circumstances CNNs are able to meet or outperform human task performance, we find that CNNs are not currently a good model for human graphical perception. We present the results of these experiments to foster the understanding of how CNNs succeed and fail when applied to data visualizations.