Miracle-dz/UniFAR-FTUs huggingface dataset:
Improved pharmacokinetics and reduced side effects of doxorubicin therapy by liposomal co-encapsulation with curcumin

Abstract The goal of the current study was to investigate the pharmacokinetic profile, tissue distribution and adverse effects of long-circulating liposomes (LCL) with curcumin (CURC) and doxorubicin (DOX), in order to provide further evidence for previously demonstrated enhanced antitumor efficacy in colon cancer models. The pharmacokinetic studies were carried out in healthy rats, following the i.v. injection of a single dose of LCL-CURC-DOX (1 mg/kg DOX). For the tissue distribution study, DOX concentration in tumours, heart and liver were measured after the administration of two i.v. doses of LCL-CURC-DOX (2.5 mg/kg DOX and 5 mg/kg CURC) to Balb/c mice bearing C26 colon tumours. Markers of murine cardiac and hepatic oxidative status were determined to provide additional insights into the benefit of co-encapsulating CURC and DOX in LCL over DOX-induced adverse effects in these organs. The current study demonstrated that the liposomal association of CURC and DOX effectively improved the pharmacokinetics and biodistribution of DOX, limiting its side effects, via CURC-dependent antioxidant effects.
Re-conceptualising gender and power relations for sexual and reproductive health: contrasting narratives of tradition, unity, and rights

Abstract Sexual and reproductive health interventions in sub-Saharan Africa will be most effective if grounded in emic (insider) perspectives of gender and power in intimate relationships. We conducted eight focus group discussions with 62 young adults in Malawi to explore conceptions of gender and power relations and areas of tension between different perspectives. We framed our enquiry according to the three social structures of the Theory of Gender and Power: the sexual division of labour, the sexual division of power, and social norms and affective attachments around femininity and masculinity. Young adults drew on interrelated and competing narratives to describe the state of gender relations, which we named tradition, unity, and rights. Participants used tradition narratives most frequently to describe patriarchal gender roles, norms and ideals. Some participants challenged this predominant discourse using unity and rights narratives. Unity narratives illustrated how love and couple reciprocity were essential sources of ‘power with’ as opposed to ‘power over’. Rights narratives were more contested than other narratives, with some participants acknowledging that women’s rights were important to the family’s survival and others viewing women’s rights as problematic for gender relations. Gender-responsive interventions should consider the tensions and intersections between multiple narratives on gender and power, including unity as a gender-equitable form of power.
Moje Ceramic Prosthetic Metatarsophalangeal Joint Replacement

Abstract Several designs and materials had been tried, in over 30 years since first metatarsophalangeal joint replacement was introduced and varying rate of successes had been reported. We reviewed nine joints in eight patients with ceramic press fit implant. The mean follow-up was13months and seven joints had satisfactory outcome, this is a short-term review report.
GingerRoot: A Novel DNA Transposon Encoding Integrase-Related Transposase in Plants and Animals

Abstract Transposable elements represent the largest components of many eukaryotic genomes and different genomes harbor different combinations of elements. Here, we discovered a novel DNA transposon in the genome of the clubmoss Selaginella lepidophylla. Further searching for related sequences to the conserved DDE region uncovered the presence of this superfamily of elements in fish, coral, sea anemone, and other animal species. However, this element appears restricted to Bryophytes and Lycophytes in plants. This transposon, named GingerRoot, is associated with a 6 bp (base pair) target site duplication, and 100–150 bp terminal inverted repeats. Analysis of transposase sequences identified the DDE motif, a catalytic domain, which shows similarity to the integrase of Gypsy-like long terminal repeat retrotransposons, the most abundant component in plant genomes. A total of 77 intact and several hundred truncated copies of GingerRoot elements were identified in S. lepidophylla. Like Gypsy retrotransposons, GingerRoots show a lack of insertion preference near genes, which contrasts to the compact genome size of about 100 Mb. Nevertheless, a considerable portion of GingerRoot elements was found to carry gene fragments, suggesting the capacity of duplicating gene sequences is unlikely attributed to the proximity to genes. Elements carrying gene fragments appear to be less methylated, more diverged, and more distal to genes than those without gene fragments, indicating they are preferentially retained in gene-poor regions. This study has identified a broadly dispersed, novel DNA transposon, and the first plant DNA transposon with an integrase-related transposase, suggesting the possibility of de novo formation of Gypsy-like elements in plants.
Relationship between Blood and Induced Sputum Eosinophils, Bronchial Hyperresponsiveness and Reversibility of Airway Obstruction in Mild-to-Moderate Chronic Obstructive Pulmonary Disease

Abstract Blood eosinophilia has been proposed as a surrogate marker for airway eosinophilia and as a predictor of treatment response in chronic obstructive pulmonary disease (COPD). The aim of the study was to assess the relationship between blood and sputum eosinophils and to investigate the association between blood and sputum eosinophil count and clinical features of mild-to-moderate COPD. We performed a retrospective analysis of blood and sputum eosinophil count, as well as demographic and lung function data in a cohort of 90 stable, steroid-naive (Global Initiative for Chronic Obstructive Lung Disease 1 or 2) COPD patients and 20 control subjects. Blood and sputum eosinophil count did not correlate both in patients with COPD (r = –0.04 p = 0.705) and in controls (r = 0.05, p = 0.838). Sputum eosinophilia (≥3%) was present in 40% of COPD patients. The median blood eosinophil count in patients with COPD was 180 (interquartile range 90–270)/μL; patients with low blood eosinophils (<180/μL) did not differ from those with high blood eosinophils (≥180/μL) in terms of forced expiratory volume in 1 second, bronchial reversibility or hyperresponsiveness. This was also the case when COPD patients with and without sputum eosinophilia were compared. At the same time, positive bronchial reversibility and positive bronchial hyperresponsiveness were observed in 2 (11%) COPD patients with high blood eosinophils and in 1 (5%) patient with sputum eosinophilia. There was a weak, albeit significant correlation (r = 0.22 p = 0.041) between blood eosinophil count and age in patients with COPD. Peripheral eosinophil count poorly reflects sputum eosinophils and lung function in stable steroid-naive mild-to-moderate COPD patients.
Kalıtsal Pıhtılaşma Faktör Eksiklikleri: Tek Merkez Deneyimi

Objective: The aim of this retrospective study was to evaluate the clinical spectrum, demographic features and complications in patients with a hereditary coagulation disorder. Material and Methods: A total of 105 patients who were being followed-up with a diagnosis of hereditary coagulation factor deficiency at the Pediatric Hematology Clinic of Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Disease Training and Research Hospital were evaluated retrospectively in this study. Results: The most frequently observed disorders were hemophilia A (46.7%), von Willebrand Disease (vWD) (16.2%) and hemophilia B (8.6%). Rare bleeding disorders (RBD) were detected in 28.5% of the study group and the most common RBDs were fibrinogen (10.5%) and factor VII (7.6%) deficiencies followed by FXI, FV and FX at 3.8%, 2.9% and 1.9%, respectively. The common initial symptom was hemarthrosis in hemophilia A and epistaxis in vWD. Eighteen patients (17%) were asymptomatic. The frequency of inhibitor development in hemophilia was 12.2%. The prevalence of hepatitis B and hepatitis C among all patients was 0.9%. Conclusion: Bleeding disorders are widely encountered in both hematology and pediatric clinics. Most patients with coagulation disorders present with bleeding symptoms but some patients may be asymptomatic or have minor symptoms that lead to a delay in diagnosis. Prompt diagnosis and treatment are critical in symptomatic patients. One has to keep in mind that not all factor deficiencies lead to severe bleeding and patients with abnormal laboratory results also need to be investigated for familial coagulation disorders too.
Zinc oxide pieces obtained by pressing and slip casting: physical, structural and photocatalytic properties

ABSTRACT Photocatalysis is a promising alternative for the decontamination of effluents. In this paper, immobilized ZnO-based photocatalysts were obtained by pressing and by slip casting. The cylindrical pieces were heat-treated at 800°C. The samples were characterized by the method based on the principle of Archimedes, XRD, FTIR, Raman, diffuse reflectance and SEM. The samples obtained by slip casting presented lower apparent density (3.12 ± 0.04 g/cm3), higher apparent porosity (44.87 ± 0.47%) and smaller grain size (0.48 ± 0.05 µm) when compared to the pressed samples, with mean apparent density of 5.37 ± 0.08 g/cm3, apparent porosity of 1.56 ± 0.10% and grain size of 0.64 ± 0.02 µm. The performances of the samples were attested by the photocatalytic degradation of Rhodamine B (RhB) under UV-C irradiation (maximum intensity at 254 nm). The samples obtained by slip casting showed photocatalytic degradation between 80% and 90%, while the pressed samples showed degradation between 40% and 60%. The reuse of the photocatalysts was evaluated over five cycles of photocatalytic degradation, in which there was no loss of performance of the samples obtained by slip casting; however, the pressed samples showed a loss of photocatalytic efficiency starting from the third-cycle. Photocatalytic assays were carried out with different dye concentrations, in which the slip casting samples showed better photocatalytic efficiency (degradation of 80% for a RhB concentration of 10 mg/L) due to higher porosity and surface area compared to pressed samples, and there was a loss of performance in higher concentrations. GRAPHICAL ABSTRACT
Traces of Imidacloprid Induce Hormesis as a Stimulatory Conditioned Response of Sweetpotato Whitefly (Hemiptera: Aleyrodidae)

Abstract Our purpose is to determine whether extremely low concentrations of imidacloprid (2–8 ppb) typically found in field soil 1–3 yr after a crop is grown using seed with a standard imidacloprid seed-coating could impact the fitness of whiteflies, Bemisia tabaci Gennadius (Hemiptera: Aleyrodidae). Results of our experiments indicate that imidacloprid-resistant whitefly larvae feeding on cotton seedlings growing in soil with 8.0 ppb imidacloprid are conditioned so that when the same individuals feed on plants treated with imidacloprid as adults their fitness, measured as fecundity, increases 30–70% compared with individuals that were not primed as larvae. This conditioning hormesis stimulates resistant whiteflies more than susceptible whiteflies, which may contribute to the selection of resistant populations.
Measuring the Burden

Alcohol use is associated with tremendous costs to the drinker, those around him or her, and society as a whole. These costs result from the increased health risks (both physical and mental) associated with alcohol consumption as well as from the social harms caused by alcohol. This issue of Alcohol Research: Current Reviews examines the public health impact of alcohol consumption, looking at the full burden of disease that can be attributed to drinking.
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

Cellular senescence has been shown to contribute to skin ageing. However, the role of melanocytes in the process is understudied. Our data show that melanocytes are the only epidermal cell type to express the senescence marker p16INK4A during human skin ageing. Aged melanocytes also display additional markers of senescence such as reduced HMGB1 and dysfunctional telomeres, without detectable telomere shortening. Additionally, senescent melanocyte SASP induces telomere dysfunction in paracrine manner and limits proliferation of surrounding cells via activation of CXCR3‐dependent mitochondrial ROS. Finally, senescent melanocytes impair basal keratinocyte proliferation and contribute to epidermal atrophy in vitro using 3D human epidermal equivalents. Crucially, clearance of senescent melanocytes using the senolytic drug ABT737 or treatment with mitochondria‐targeted antioxidant MitoQ suppressed this effect. In conclusion, our study provides proof‐of‐concept evidence that senescent melanocytes affect keratinocyte function and act as drivers of human skin ageing.
Retracted: Negative feedback of NF‐κB signaling by long noncoding RNA MALAT1 controls lipopolysaccharide‐induced inflammation injury in human lung fibroblasts WI‐38

Retraction: 'Negative feedback of NF‐κB signaling by long noncoding RNA MALAT1 controls lipopolysaccharide‐induced inflammation injury in human lung fibroblasts WI‐38', by Wei Zhu and Xuelin Men, J Cell Biochem. 2020; 1945‐1952: The above article, published online on 21 October 2019 in Wiley Online Library (https://doi.org/10.1002/jcb.29429), has been retracted by agreement between the authors, the journal's Editor in Chief, Prof. Dr. Christian Behl, and Wiley Periodicals LLC. The authors asked to retract this manuscript, initially, but were not available for further comments during the investigation.
Applied Deep Learning in Plastic Surgery: Classifying Rhinoplasty With a Mobile App.

BACKGROUND Advances in deep learning (DL) have been transformative in computer vision and natural language processing, as well as in healthcare. The authors present a novel application of DL to plastic surgery. Here, the authors describe and demonstrate the mobile deployment of a deep neural network that predicts rhinoplasty status, assess model accuracy compared to surgeons, and describe future directions for such applications in plastic surgery. METHODS A deep convolutional neural network ("RhinoNet") was developed to classify rhinoplasty images using only pixels and rhinoplasty status labels ("before"/"after") as inputs. RhinoNet was trained using a dataset of 22,686 before and after photos which were collected from publicly available sites. Network classification was compared to that of plastic surgery attendings and residents on 2269 previously-unseen test-set images. RESULTS RhinoNet correctly predicted rhinoplasty status in 85% of the test-set images. Sensitivity and specificity of model predictions were 0.840 (0.79-0.89) and 0.826 (0.77-0.88), respectively; the corresponding values for expert consensus predictions were 0.814 (0.76-0.87) and 0.867 (0.82-0.91). RhinoNet and humans performed with effectively equivalent accuracy in this classification task. CONCLUSION The authors describe the development of DL applications to identify the presence of superficial surgical procedures solely from images and labels. DL is especially well suited for unstructured, high-fidelity visual and auditory data that does not lend itself to classical statistical analysis, and may be deployed as mobile applications for potentially unbridled use, so the authors expect DL to play a key role in many areas of plastic surgery.
Impact of school-based allied health therapy via telehealth on children’s speech and language, class participation and educational outcomes

Abstract Introduction Access to telehealth services for children living in rural and remote areas of Australia is very limited. The delivery of allied health therapies to children in school via telehealth may help reduce inequality and improve academic outcomes over time. Methods A service delivering speech and language therapy (SLT) and occupational therapy (OT) via videoconferencing to children at five rural schools was prospectively evaluated. Each child’s teacher rated their speech and language, participation in class and educational outcomes at the beginning and end of semester. Change in the summative teacher-rating index over the first and subsequent semesters in which a child received therapy was examined. Independent predictors of change were identified using multivariable linear regression. Results Over two years, 1029 sessions of SLT and 531 sessions of OT were delivered to 98 children (67% male, 38% in Prep at commencement) via telehealth. In their first semester of therapy, 57 children received SLT, 37 OT and four both therapies. The mean teacher-rating index significantly improved from the beginning (35.05 ± 10.68) to end (40.02 ± 11.75) of the first semester of therapy (p < 0.001). In multivariable linear regression, grade, school and baseline rating were significantly associated with the end-of-semester teacher-rating index. Discussion Delivering allied health therapy by videoconference may enable children to better engage with schooling. Differences in improvements by grade suggest improvements may be maximised by targeting therapy at certain year levels. This model may be useful in areas with limited access to allied health services.
Update: Interim Guidance for Health Care Providers Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use Associated Lung Injury — United States, October 2019

CDC, the Food and Drug Administration (FDA), state and local health departments, and public health and clinical partners are investigating a multistate outbreak of lung injury associated with the use of electronic cigarette (e-cigarette), or vaping, products. In late August, CDC released recommendations for health care providers regarding e-cigarette, or vaping, product use associated lung injury (EVALI) based on limited data from the first reported cases (1,2). This report summarizes national surveillance data describing clinical features of more recently reported cases and interim recommendations based on these data for U.S. health care providers caring for patients with suspected or known EVALI. It provides interim guidance for 1) initial clinical evaluation; 2) suggested criteria for hospital admission and treatment; 3) patient follow-up; 4) special considerations for groups at high risk; and 5) clinical and public health recommendations. Health care providers evaluating patients suspected to have EVALI should ask about the use of e-cigarette, or vaping, products in a nonjudgmental and thorough manner. Patients suspected to have EVALI should have a chest radiograph (CXR), and hospital admission is recommended for patients who have decreased blood oxygen (O2) saturation (<95%) on room air or who are in respiratory distress. Health care providers should consider empiric use of a combination of antibiotics, antivirals, or steroids based upon clinical context. Evidence-based tobacco product cessation strategies, including behavioral counseling, are recommended to help patients discontinue use of e-cigarette, or vaping, products. To reduce the risk of recurrence, patients who have been treated for EVALI should not use e-cigarette, or vaping, products. CDC recommends that persons should not use e-cigarette, or vaping, products that contain tetrahydrocannabinol (THC). At present, CDC recommends persons consider refraining from using e-cigarette, or vaping, products that contain nicotine. Irrespective of the ongoing investigation, e-cigarette, or vaping, products should never be used by youths, young adults, or women who are pregnant. Persons who do not currently use tobacco products should not start using e-cigarette, or vaping, products.
Cumulative deceleration area: a simplified predictor of metabolic acidemia

Abstract Objective Fetal monitoring, ubiquitous in obstetrics is used to predict and prevent intrapartum fetal injury. Despite decades of education and nomenclature revision, clinicians show low agreement on key elements, including the types of deceleration and hence their presumed etiology. Cumulative deceleration area is not dependent on deceleration type and could potentially mitigate this problem. Although deceleration area has shown promise as a marker of acidemia, no reports have shown how deceleration area evolves in late labor. Advances in computerization allow for direct measurement of deceleration area and standard fetal heart rate (FHR) patterns. The objective of this study was to compare the evolution and discrimination performance of deceleration area and other FHR patterns in late labor in term neonates with metabolic acidemia (MA) and in those with normal cord gases. Methods This retrospective cohort study included women with a term singleton (≥37 weeks) in cephalic presentation with cord gas data and FHR tracings available for analysis. MA included neonates with an umbilical artery base deficit >12 mmol/L (n = 132). Controls included those with normal cord gases (base deficit <8 mmol/L) and a 5-minute Apgar score of >6 (n = 1498). Deceleration area and other FHR patterns were summarized and compared in 30-minute segments over the last five hours. Receiver-operating characteristic curves were constructed and AUCs compared. Results Deceleration area had the highest AUC (0.702, 95% CI 0.655–0.749) and was a superior marker of MA compared to baseline (AUC 0.588, 95% CI 0.530–0.645), baseline variability (AUC 0.611, 95% CI 0.558–0.663), and number of late decelerations (AUC 0.582, 95% CI 0.527–0.637). Conclusion Cumulative deceleration area reduces the necessity to determine deceleration type. In a single number, it objectively quantifies three important aspects of decelerations; frequency, depth and duration and was a superior marker of MA compared to baseline level, baseline variability and number of late decelerations. The acidemia group had higher deceleration area over the last two hours prior to delivery. This result indicates that the cumulative area and persistence of repetitive decelerations is important clinically.
Refractory Chronic Rhinosinusitis: Etiology & Management

The true incidenceof RCRS is unknown. It is estimated that at least 10 % of patients with CRS continue to be symptomatic after appropriate endoscopic sinus surgery (ESS) with long term follow up. This 10% failure rate translates into 30,000 patients yearlyundergoing ESS with poor postoperative outcome.Because these numbers are cumulative over years, approximately450,000 cases in the United States are currently estimatedto have chronic sinusitis that is unresponsive to medical and surgical therapy. Today, these chronic patients form a significant portion of most rhinology practices. (Desrosiers, 2004).