Miracle-dz/UniFAR-FTUs huggingface dataset:
WING-NUS at SemEval-2017 Task 10: Keyphrase Extraction and Classification as Joint Sequence Labeling

We describe an end-to-end pipeline processing approach for SemEval 2017’s Task 10 to extract keyphrases and their relations from scientific publications. We jointly identify and classify keyphrases by modeling the subtasks as sequential labeling. Our system utilizes standard, surface-level features along with the adjacent word features, and performs conditional decoding on whole text to extract keyphrases. We focus only on the identification and typing of keyphrases (Subtasks A and B, together referred as extraction), but provide an end-to-end system inclusive of keyphrase relation identification (Subtask C) for completeness. Our top performing configuration achieves an F_1 of 0.27 for the end-to-end keyphrase extraction and relation identification scenario on the final test data, and compares on par to other top ranked systems for keyphrase extraction. Our system outperforms other techniques that do not employ global decoding and hence do not account for dependencies between keyphrases. We believe this is crucial for keyphrase classification in the given context of scientific document mining.
What do family members expect from the family physician of a deceased loved one?

BACKGROUND AND OBJECTIVES This study examined what actions are expected from a family physician by the family members of a deceased patient immediately following the death of the patient. METHODS Those listed as next of kin on the charts of deceased patients of a suburban family practice residency were asked to complete a questionnaire about their expectations of their family member's family physician after the death. RESULTS Expectation of the surveyed actions was surprisingly low, with attendance at the funeral the least expected, followed closely by acknowledgment of the anniversary of the family member's death. Nearly half of the respondents expected a telephone call shortly after the death, while close to one third expected the physician to ask about their emotional well-being at their next visit. CONCLUSIONS The results suggest that family members do not expect or rarely expect any action from their family member's family physician after the death. However, comments received with the survey indicate that any gesture of sympathy or show of concern from the family physician was greatly appreciated by the survivors.
The Role of Adenosine A2A Receptor, CYP450s, and PPARs in the Regulation of Vascular Tone

Adenosine is an endogenous mediator involved in a myriad of physiologic functions, including vascular tone regulation. It is also implicated in some pathologic conditions. Four distinct receptor subtypes mediate the effects of adenosine, such as its role in the regulation of the vascular tone. Vascular tone regulation is a complex and continuous process which involves many mechanisms and mediators that are not fully disclosed. The vascular endothelium plays a pivotal role in regulating blood flow to and from all body organs. Also, the vascular endothelium is not merely a physical barrier; it is a complex tissue with numerous functions. Among adenosine receptors, A2A receptor subtype (A2AAR) stands out as the primary receptor responsible for the vasodilatory effects of adenosine. This review focuses on important effectors of the vascular endothelium, including adenosine, adenosine receptors, EETs (epoxyeicosatrienoic acids), HETEs (hydroxyeicosatetraenoic acids), PPARs (peroxisome proliferator-activated receptors), and KATP channels. Given the impact of vascular tone regulation in cardiovascular physiology and pathophysiology, better understanding of the mechanisms affecting it could have a significant potential for developing therapeutic agents for cardiovascular diseases.
Longer term clinical outcomes after radiofrequency therapy for refractory gastroesophageal reflux disease (GERD)

Stretta for GERD refractory to PPI therapy has received very limited evaluation. Aim: To evaluate long-term efficacy of Stretta procedure used for management of refractory GERD. Methods: Thirty-two patients with refractory GERD to at least double doses PPI Underwent Stretta therapy. Mean follow-up time was 2.5 years. RESULTS: Stretta procedure was successfully completed in all patients with no serious complications. At baseline, HRQL while off medications was 26.3, compared with 17.1 at the end of the follow-up (p < 0.05). Mean HRQL on medications at baseline was 24.3, compared with 14.24 at the end of the follow-up (p < 0.05). At baseline all patients were taking at least double dose PPI daily. At the end of follow-up, two patients (6.25%) had discontinued their PPI’s, and an additional 18 patients (56%) had reduced PPI doses by ≥50%. HRQL normalized while on medications in nine patients (28%). Conclusions: In this difficult patient population with refractory GERD symptoms, Stretta procedure was a feasible, safe and partially effective in decreasing symptoms and PPI use.
[Randomized FARVATER study. Part 2. Effect of atorvastatin on endothelial function, distensibility and stiffness of vascular wall].

AIM To elucidate effect of two doses of atorvastatin (10 and 20 mg/day) on endothelial function, distensibility and stiffness of vascular wall. MATERIAL AND METHODS Patients (n=50) with documented ischemic heart disease and hyperlipidemia were randomized to 10 or 20 mg/day of atorvastatin (Atoris, KRKA). Endothelial function and common carotid artery wall distensibility and stiffness were assessed at baseline and after 12 and 24 weeks of treatment. RESULTS Administration of both 10 and 20 mg/day doses of atorvastatin for 6 weeks was associated with significant lowering of total cholesterol (CH), triglycerides (TG) and low density lipoprotein (LDL) CH (24.5, 18.4, 34.9% and 29.1, 28.2, 40.9%, respectively). After 24 weeks LDL CH lowering from baseline reached 34.9 and 43.9% (p<0.001) and that of TG - 22 and 15%, in 10 and 20 mg/day groups, respectively. There were no significant differences between 10 and 20 mg/day groups in baseline values of endothelium dependent vasodilation (EDV), carotid artery distensibility and stiffness (7.28 and 6.64%, 21.60 and 20.15, 8.04 and 9.19 U, in 10 and 20 mg/day groups, respectively). After 3 months of treatment there occurred significant 38.4% (10 mg/day) and 45.4% (20 mg/day) increases of EDV. Significant 27.6% (10 mg/day) and 28.8% (20 mg/day) enhancement of vascular distensibility was noted after 24 weeks. Vascular wall stiffness decreased 33.4% (p=0.008) and 31.3% (p=0.002) in 10 and 20 mg/day groups, respectively.
Influence of Objective Three-Dimensional Measures and Movement Images on Surgeon Treatment Planning for Lip Revision Surgery

Objective To determine whether a systematic evaluation of facial soft tissues of patients with cleft lip and palate, using facial video images and objective three-dimensional measurements of movement, change surgeons' treatment plans for lip revision surgery. Design Prospective longitudinal study. Setting The University of North Carolina School of Dentistry. Patients, Participants A group of patients with repaired cleft lip and palate (n =21), a noncleft control group (n = 37), and surgeons experienced in cleft care. Interventions Lip revision. Main Outcome Measures (1) facial photographic images; (2) facial video images during animations; (3) objective three-dimensional measurements of upper lip movement based on z scores; and (4) objective dynamic and visual three-dimensional measurement of facial soft tissue movement. Results With the use of the video images plus objective three-dimensional measures, the operating surgeon changed the problem list of the surgical treatment plan for 86% of the patients (95% confidence interval, 0.64 to 0.97) and the surgical goals for 71% of the patients (95% confidence interval, 0.48 to 0.89). The surgeon group varied in the percentage of patients for whom the problem list was modified, ranging from 24% (95% confidence interval, 8% to 47%) to 48% (95% confidence interval, 26% to 70%) of patients, and the percentage for whom the surgical goals were modified, ranging from 14% (94% confidence interval, 3% to 36%) to 48% (95% confidence interval, 26% to 70%) of patients. Conclusions For all surgeons, the additional assessment components of the systematic valuation resulted in a change in clinical decision making for some patients.
[Spironolactone ameliorates rat pulmonary fibrosis induced by bleomycin A5].

OBJECTIVE The purpose of this study was to investigate the role of aldosterone in pulmonary fibrosis and the protective effect of anti-aldosterone treatment. METHOD Rats were divided into control, fibrosis and treatment groups; rat pulmonary fibrosis was induced by endotracheal injection of bleomycin A5 and spironolactone was given 100 mg/kg daily in drinking water to treatment group. 28 days later, plasma, bronchoalveolar lavage fluid(BALF) and tissue aldosterone concentration, as well as lung collagen levels, were determined. RESULT Plasma aldosterone was higher in fibrosis group than that in control group(469 +/- 161 pg/ml and 319 +/- 115 pg/ml, respectively), but without significant difference (P > 0.05); spironolactone could ameliorate the extent of pulmonary fibrosis, the level of lung collagen was 25% less than that of fibrosis group (3.4 +/- 0.5 mg/g lung and 4.6 +/- 1.2 mg/g lung, respectively; q = 3.7893, P < 0.05), and the level of lung protein was 22% less (50 +/- 4 mg/g lung and 65 +/- 6 mg/g lung, respectively; P < 0.01). CONCLUSION Spironolactone had some protective effects on pulmonary fibrosis, and aldosterone might play a role in the development of pulmonary fibrosis.
Heterotopic ossification encasing a plombage cavity

An 80-year-old patient presented with a chronic right sided chest wall sinus discharging pus. The patient had undergone an ipsilateral thoracoplasty and Lucite ball plombage for the treatment of tuberculosis in 1955, and the sinus was known to communicate with a plombage cavity. Until this presentation the sinus was uncomplicated, occasionally discharging clear fluid and a conservative approach to management was adopted. At this presentation, however, the discharge was culture positive for Staphylococcus aureus . Removal of the Lucite balls …
Observer Kalman Filter Identification for Output-Only Systems Using Interactive Structural Modal Identification Toolsuite

AbstractSeveral modal identification techniques have been developed in the past few decades, and their use is rapidly expanding due to new focus on the instrumentation of major structures. This paper focuses on the expansion of the eigenvalue realization algorithm (ERA)–observer Kalman filter identification (OKID) to identify modal parameters of output-only systems (OO) by splitting the state-space model into deterministic and stochastic subsystems (ERA-OKID-OO). The performance is then compared with other output-only identification methods in terms of the level of accuracy and efficiency. A newly developed software package [Structural Modal Identification Toolsuite (SMIT)] is used to provide a uniform and convenient way of utilizing several system identification (SID) methods, including variations of ERA, auto-regressive with exogenous terms (ARX) models, system realization using information matrix (SRIM), and numerical algorithms for subspace state space system identification (N4SID). The main purpose o.
Glottal closure and opening detection for flexible parametric voice coding

The knowledge of glottal closure and opening instants (GCI/GOI) is useful for many speech analysis applications. A Pitch-synchronous waveform encoding of voice is one such application. In this paper, a dynamic programming is employed to solve for the global close/open phase segmentation based on the polynomial parametric waveform of the derivative glottal waveform and its quasi-periodicity. Not only does the algorithm identify GCIs, but also the elusive GOIs, and as a by-product, the parameters of the glottal excitation waveform. The results show its effectiveness compared with a classical method. Its application to parametric voice encoding which allows for simple time-pitch scaling as well as voicing quality conversion is demonstrated.
ICI 204,636, an atypical antipsychotic: efficacy and safety in a multicenter, placebo-controlled trial in patients with schizophrenia. U.S. SEROQUEL Study Group.

ICI 204,636 is a new, potentially atypical antipsychotic. In early phase II trials, the antipsychotic was well tolerated and results suggested efficacy in the treatment of the positive and negative symptoms of schizophrenia. The efficacy and safety of ICI 204,636 were evaluated on a larger scale in a 6-week, multicenter, double-blind trial. Hospitalized patients who met DSM-III-R criteria for chronic or subchronic schizophrenia with acute exacerbation, as well as other criteria, were randomized to ICI 204,636 (75 to 750 mg daily) (N = 54) or placebo (N = 55). Patients were assessed weekly by use of the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS), and Clinical Global Impression Scale (CGI) for efficacy and the Simpson Scale and Abnormal Involuntary Movement Scale for extrapyramidal side effects (EPS). Significant differences (p < or = 0.05) between treatment groups, which favored ICI 204,636, were identified throughout the trial. Endpoint differences were significant (by analysis of covariance) for BPRS factor IV (activation) and SANS scores and were marginally significant for total BPRS, BPRS factor III (thought disturbance), BPRS positive-symptom cluster, and CGI Severity of Illness item scores (p = 0.07, 0.09, 0.06, and 0.09, respectively). ICI 204,636 was well tolerated, although it was associated with mild transient increases in alanine aminotransferase and a higher incidence of somnolence and anticholinergic effects compared with placebo. In the dose range studied, treatment with ICI 204,636 did not induce EPS as determined by analysis of Simpson Scale total scores and lack of treatment-emergent acute dystonic reactions. Furthermore, ICI 204,636 did not produce sustained levels of prolactin; the mean change from baseline at endpoint (-7.2 micrograms/L) was comparable (p = 0.44) to that for placebo (-8.2 micrograms/L). These findings distinguish ICI 204,636 from standard antipsychotics and confirm preclinical predictions that ICI 204,636 is an atypical antipsychotic.
Primitive anaerobic protozoa: a false concept?

Most of us feel, from time to time, that other authors have not acknowledged the work of our own or other groups or have omitted to interpret important aspects of their own data. Perhaps we have observations that, although not sufficient to merit a full paper, add a further dimension to one published by others. In other instances we may have a useful piece of methodology that we would like to share.
Optimal Cloudlet Placement and User to Cloudlet Allocation in Wireless Metropolitan Area Networks

Mobile applications are becoming increasingly computation-intensive, while the computing capability of portable mobile devices is limited. A powerful way to reduce the completion time of an application in a mobile device is to offload its tasks to nearby cloudlets, which consist of clusters of computers. Although there is a significant body of research in mobile cloudlet offloading technology, there has been very little attention paid to how cloudlets should be placed in a given network to optimize mobile application performance. In this paper we study cloudlet placement and mobile user allocation to the cloudlets in a wireless metropolitan area network (WMAN). We devise an algorithm for the problem, which enables the placement of the cloudlets at user dense regions of the WMAN, and assigns mobile users to the placed cloudlets while balancing their workload. We also conduct experiments through simulation. The simulation results indicate that the performance of the proposed algorithm is very promising.
Weight at menarche: similarity for well-nourished and undernourished girls at differing ages, and evidence for historical constancy.

The mean weight at menarche of 30 undernourished Alabama girls did not differ from that of 30 well-nourished controls, although the undernourished girls attained menarche two years later than controls and at a significantly greater height. This supports the hypothesis that a critical weight triggers menarche. The weight-dependency of menarche, irrespective of a causal relationship, reduces variation in body size at sexual maturity by delaying or advancing the age of sexual maturation as a compensation for environmental or genetic variation. Recent and historical evidence indicates that the mean weight at menarche of Caucasian girls has been about 46 kg. for over a century.
Indications for, Contraindications to, and Interruption of Craniofacial Procedures

In spite of increasing experience with skull base surgery, some of the guidelines for indications for operations may vary according to the institution. One-hundred two patients underwent craniofacial oncologic resections at our institution from 1982 to 1995. A retrospective analysis of the indications for and contraindications to these procedures was undertaken. The main indications for malignant tumors were skin lesions with direct invasion of the anterior or lateral skull base (69%) and nasal-paranasal sinus tumors (21%). The main indications for benign tumors were glomus lesions (26%), menigiomas (22%), and fibro-osseous lesions of the anterior skull base (19%). The main contraindications were extensive invasion of the central nervous system, invasion of the cavernous sinus and/or internal carotid artery by aggressive malignancies, and bilateral orbital invasion in a nonblind patient. Also, 6 patients had their procedures interrupted during craniotomy for several reasons — extensive central nervous system invasion (2 cases), bilateral orbital invasion (1), lack of brain retraction (1), lack of histologic diagnosis during the operation (1), and purulent discharge at the frontal sinus (1). Craniofacial oncologic operations are extensive surgical procedures that have to be properly indicated in order to obtain low levels of morbidity and mortality. The selection of cases is of paramount importance. In some instances, it seems advisable even to interrupt these operations in the first phase.
Ochratoxin A secretion in primary cultures of rabbit renal proximal tubule cells.

Primary cultures of rabbit renal proximal tubule cells grown under improved culture conditions were used to study the transepithelial transport of the nephrotoxic mycotoxin ochratoxin A. The basal-to-apical transepithelial flux, i.e., secretion, of this fluorescence organic acid was measured in primary cultures of rabbit renal proximal tubule cells. The basal-to-apical flux of ochratoxin A increased with time and reached a steady state after 12 h. On the other hand, the apical-to-basal flux, i.e., reabsorption, of ochratoxin A was minimal over time. The secretory flux of ochratoxin A was as much as eightfold greater than the reabsorptive flux, indicating that net secretion is the primary mechanism for ochratoxin A clearance by the proximal tubule. The kinetic analysis of ochratoxin A flux revealed secretion to be a saturable and very high-affinity process with an apparent K50 of 0.33 +/- 0.21 mM. A saturating concentration of the prototypical organic anion substrate para-aminohippurate (PAH) reduced ochratoxin A secretion by approximately 75%. The kinetic analysis of PAH inhibition of ochratoxin A secretion revealed an IC50 of 195 mM, which is similar to the IC50 for PAH inhibition of peritubular ochratoxin A uptake in tubule suspensions and the Km, values for peritubular PAH uptake. The organic anions probenecid, octanoate, and alpha-ketoglutarate reduced ochratoxin A excretion to the same degree as PAH, whereas the amino acid phenylalanine had a minimal effect on ochratoxin A secretion. Thus, collectively, these observations indicate that the secretion of ochratoxin A in primary cultures of rabbit renal proximal tubules is limited to the organic anion secretory pathway. The high affinity measured for the basal-to-apical flux of ochratoxin A suggests that at concentrations typical of naturally occurring exposures, transepithelial secretion by the organic anion transport pathway represents a significant avenue for excretion of this mycotoxin by the renal proximal tubule.
Polymorphisms in TLR9 but not in TLR5 increase the risk for duodenal ulcer and alter cytokine expression in the gastric mucosa

Colonization of the gastric mucosa by Helicobacter pylori can lead to peptic ulcer and gastric adenocarcinoma. TLRs are signaling receptors involved in the recognition of microorganisms, and polymorphisms in their genes may influence the innate and adaptive immune response to H. pylori, affecting the clinical outcomes of the infection. We assessed the association between single nucleotide polymorphisms in TLR9 and TLR5 and gastroduodenal diseases. All patients were genotyped by allelic discrimination in regions 1174C > T and 1775A > G of TLR5 and −1237T > C and 2848G > A of TLR9. The 2848A allele of TLR9 was more frequent in duodenal ulcer and showed an association of risk with this pathology. Polymorphisms in TLR5 were not found to be associated with disease. Patients with polymorphisms in TLR9 and TLR5 expressed significantly lower levels of IL-1β and TNF-α, whereas polymorphisms in TLR5 also decreased the expression of IL-6 and IL-10. Our findings suggest that 2848G > A polymorphism in TLR9 increases the risk for the development of duodenal ulcer probably by modifying the inflammatory response to H. pylori infection. This is the first study to show an association of 2848A allele of TLR9 with duodenal ulcer and with altered expression of inflammatory cytokines in the gastric mucosa.
The predictive value of the baseline Oswestry Disability Index in lumbar disc arthroplasty.

OBJECT The goal of the study was to determine patient factors predictive of good outcome after lumbar disc arthroplasty. Specifically, the paper examines the relationship of the preoperative Oswestry Disability Index (ODI) to patient outcome at 1 year. METHODS The study is a retrospective review of 20 patients undergoing a 1-level lumbar disc arthroplasty at the author's institution between 2004 and 2008. All data were collected prospectively. Data included the ODI, visual analog scale scores, and patient demographics. RESULTS All patients underwent a 1-level disc arthroplasty at L4-5 or L5-S1. The patients were divided into 2 groups based on their baseline ODI. Patients with an ODI between 38 and 59 demonstrated better outcomes with lumbar disc arthroplasty. Only 1 (20%) of 5 patients with a baseline ODI higher than 60 reported a good outcome. In contrast, 13 (87%) of 15 patients with an ODI between 38 and 59 showed a good outcome (p = 0.03). The negative predictive value of using ODI > 60 is 60% in patients who are determined to be candidates for lumbar arthroplasty. CONCLUSIONS Lumbar arthroplasty is very effective in some patients. Other patients do not improve after surgery. The baseline ODI results are predictive of outcome in patients selected for lumbar disc arthroplasty. A baseline ODI > 60 is predictive of poor outcome. A high ODI may be indicative of psychosocial overlay.
USENIX Association Proceedings of the FREENIX Track : 2004

During the last few years, thousands of volunteers have created a large body of free software. Even though this accomplishment shows that the free software development model works, there are some drawbacks associated with this model. Due to the volunteer nature of most free software projects, it is impossible to fully rely on participants. Volunteers may become busy and neglect their duties. This may lead to a steady decrease of quality as work is not being carried out. The problem of inactive volunteers is intensified by the fact that most free software projects are distributed, which makes it hard to quickly identify volunteers who neglect their duties. This paper shows Debian’s approach to inactive volunteers. Insights presented here can be applied to other free software projects in order to implement effective quality assurance strategies.