Miracle-dz/UniFAR-FTUs huggingface dataset:
Advertising Spillovers: Evidence from Online Field Experiments and Implications for Returns on Advertising

The author analyzes the impact of online ads on the advertiser's competitors, using data from randomized field experiments on a restaurant-search website. He finds that ads increase the chances of sales for nonadvertised restaurants significantly. The spillover benefits are concentrated on restaurants that serve the advertiser's cuisine and have a high rating on the restaurant-search website. The extent of spillovers also depends on the intensity of the advertising effort. The spillovers are largest when the intensity (frequency) of advertising is low. As the intensity increases, the spillovers disappear and the advertiser gains more sales. These patterns are consistent with the following mechanism: ads increase the chance of consumers buying the advertised product but also remind consumers of similar (nonadvertised) options. Higher ad intensity leads to a stronger direct effect favoring the advertiser and can offset the spillover caused by the broader reminder.
Market orientation, marketing capabilities, and firm performance

Drawing on traditional resource‐based theory and its recent dynamic capabilities theory extensions, we examine both the possession of a market orientation and the marketing capabilities through which resources are deployed into the marketplace as drivers of firm performance in a cross‐industry sample. Our findings indicate that market orientation and marketing capabilities are complementary assets that contribute to superior firm performance. We also find that market orientation has a direct effect on firms' return on assets (ROA), and that marketing capabilities directly impact both ROA and perceived firm performance. Copyright © 2009 John Wiley & Sons, Ltd.
The new product development process: let the voice of the salesperson be heard

Purpose – The purpose of this research is to provide an empirical examination of the role of the salesperson in the new product/service development process.Design/methodology/approach – A survey was mailed to 2,650 sales managers representing US firms across the nation, and the resulting sample size consisted of 246 respondents with a response rate of 9.3 percent. The survey sample included firms with a business‐to‐business emphasis, and those with a minimum of 50 employees.Findings – The majority of the respondents reported that salespeople are indirectly or directly involved in the new product/service development process. In spite of this contribution, many firms do not directly reward salespeople for their involvement. Offering appropriate incentives could greatly increase their efforts to collect information for new product/service idea generation.Research limitations/implications – Suggested future research includes the perspectives of salespeople, new product development directors, etc. In addition,.
COMPARATIVE EVALUATION OF THE FUNCTIONAL AND SENSORY CHARACTERISTICS OF THREE TRADITIONAL FERMENTED CASSAVA PRODUCTS

This study provides scientific evidence to test the hypothesis that the flours and cooked forms of fufu, lafun and pupuru can suitably serve as substitutes for each other in the food markets and eateries, respectively. Sixteen functional properties of flours were compared statistically. Similarly, discrimination and preference tests were also conducted on the cooked dough. About 88% of the functional properties of the products were significantly different (p<0.05). Cooked dough samples were significantly different in terms of the appearance, odour and texture. Pupuru had the highest preference scores for all the sensory attributes. Dough appearance was the most important factor determining the overall acceptability of the products. Conclusively, the flours and cooked dough from traditionally processed fufu, lafun and pupuru cannot suitably substitute for each other in food markets and consumers end.
Role of CCL18 in asthma and lung immunity

Allergic asthma is a prototypic Th2 mediated disease, where chemokines orchestrate the inflammatory cell recruitment. Most chemokines have a pro‐inflammatory role. In this review, we focus on the potential role, in asthma and lung immunity, of CCL18 a chemokine both constitutively expressed at high levels in the lung and induced in inflammatory conditions. This chemokine is mainly produced by antigen presenting cells, and induced by Th2 type cytokines. The available data suggest that this chemokine may exhibit dual functions, with both pro‐ and anti‐inflammatory properties, the latter through its ability to generate adaptive regulatory T cells in healthy subjects, with a loss of function in allergic patients. However, the functional implications are at the moment hampered by the lack of data on the nature of its putative receptor, and the absence of murine orthologue.
Nitrate Reductases from Wild-Type and nr(1)-Mutant Soybean (Glycine max [L.] Merr.) Leaves : II. Partial Activity, Inhibitor, and Complementation Analyses.

Soybean (Glycine max [L.] Merr.) leaves have been shown to contain three forms of nitrate reductase (NR). Two of the forms, which are present in leaves of wild-type (cv. Williams) plants grown in the absence of NO(3) (-), are termed constitutive and designated c(1)NR and c(2)NR. The third form, which is present in NO(3) (-)-grown mutant (nr(1)) plants lacking the constitutive forms, is termed inducible and designated iNR. Samples of c(1)NR, c(2)NR, and iNR obtained from appropriately treated plants were analyzed for the presence of partial activities, response to inhibitors, and ability to complement a barley NR which lacks the molybdenum cofactor (MoCo) but is otherwise active.The three forms were similar to most assimilatory NR enzymes in that they (a) exhibited NADH-cytochrome c reductase, reduced flavin mononucleotide-NR, and reduced methyl viologen-NR partial activities; (b) were inhibited by p-hydroxymercuribenzoate at the site of initial electron transport through each enzyme; (c) were more inhibited by CN(-) in their reduced enzyme state as compared with their oxidized state; and (d) complemented a MoCo-defective NR (e.g. contained cofactors with characteristics similar to the MoCo found in barley NR and commercial xanthine oxidase). However, among themselves, they showed dissimilarities in their response to treatment with HCO(3) (-) and CN(-), and in their absolute ability to complement the barley NR. The site of effect for these treatments was the terminal cofactor-containing portion of each enzyme. This indicated that, although a terminal cofactor (presumably a MoCo) was present in each form, structural or conformational differences existed in the terminal cofactor-protein complex of each form.
Predictive factors of malignancy in patients with adnexal masses.

INTRODUCTION Good preoperative tumor triage is essential for choosing the appropriate approach. OBJECTIVE The study aim was to identify factors from standard preoperatively collected data, which could predict the nature of adnexal masses prior surgery. MATERIAL AND METHODS The study involved all women treated in the Clinic for Gynecology and Obstetrics Clinical Center of Serbia for adnexal tumors throughout a period of 18 months. On admission, detailed anamnestical and laboratory data were obtained and ultrasound scans were performed. Obtained data were compared with hystopathological findings of tumors. Methods of correlation and logistic regression were applied to create association models. RESULTS Three new models for predicting tumor nature were achieved from anamnestical data, characteristics of women and tumors, and laboratory analyses. Two statistically significant (p = 0.000) equations were obtained for anamnestical data and characteristics of women and tumors, while three were made for laboratory analyses. Sensitivity of anamnestical malignancy index (AMI) was 73.33%, specificity 72.87%, positive predictive value (PPV) 39.49% and negative predictive value (NPV) 91.88%. Sensitivity of characteristic malignancy index (CMI) was 92.38%, specificity 67.36%, PPV 40.59% and NPV 97.34%. Sensitivity of laboratory malignancy index (LMI) was 56.45%, specificity 90.24%, PPV 68.63%, and NPV 84.57%. CONCLUSIONS The best predictors of malignancy are menopausal status, body mass index (BMI), age, metastases, ascites, tumor marker CEA level, and erythrocyte sedimentation rate (ESR). Along with the risk of malignancy index (RMI), for more reliable triage and preoperative tumor evaluation the authors propose introduction of another three indexes (AMI, CMI, LMI) in clinical practice.
Integral-observer-based chaos synchronization

In this paper, a new scheme based on integral observer approach is designed for a class of chaotic systems to achieve synchronization. Unlike the proportional observer approach, the proposed scheme is demonstrated to be effective under a noisy environment in the transmission channel. Based on the Lyapunov stability theory, a sufficient condition for synchronization is derived in the form of a Lyapunov inequality. This Lyapunov inequality is further transformed into a linear matrix inequality (LMI) form by using the Schur theorem and some matrix operation techniques, which can be easily solved by the LMI toolboxes for the design of suitable control gains. It is demonstrated with the Murali-Lakshmanan-Chua system that a better noise suppression and a faster convergence speed can be achieved for chaos synchronization by using this integral observer scheme, as compared with the traditional proportional observer approach.
Evaluation of Different Breeds of Beef Cattle Bull's Capacity in Producing Frozen Sperms

Frozen semen production level was specified by quality of fresh semen. Different breeds of beef cattle produce various quality of fresh semen. The aim of this study was to determine differences of frozen sperms production competence of various breed of beef in Artificial Insemination (AI) Center of Ungaran. This study was conducted at Artificial Insemination (AI) Center of Ungaran, Semarang, Central Java, Indonesia. Data collecting was done based on recording data of sperm from 2014 to 2015. Sperm quality and frozen sperm production were observed in Simmental bull, Limousine bull, Brahman bull and Ongole bull. 39 bulls were observed that are 18 Simental, 8 Limousin, 8 PO and 5 Brahman. The method was done by sampling data analysis using Analysis of Variant (ANOVA). The study design was used completely randomized design of sperms production and average production of frozen semen variation between breeds. During 2014 the best sperm production is Limousin bull, but the highest total number of frozen semen produced is Brahman bull. There is no significant difference in the average production of frozen semen among the Limousine cattle, Simental and Brahman, but in the Brahman cattle does. Each individual has the ability to produce spermatozoa with resistance in different freezing processes. The conclusion is sperms production and average production of frozen semen varies between breeds and during 2014 to 2015 the best production is Limousin bulls.
An evaluation of information system using HOT-FIT model: A case study of a hospital information system

Kasih Group has used the information system, Hospital Information System (HIS) Kasih Group used for recording and reporting. After 8 years are applied, the author felt the need to do an evaluation of the information systems to identify and measure the success rate of the application/ implementation of the HIS Kasih Group. This study aims to evaluate the system information by using HOT FIT Model. HOT FIT Model has four perspectives namely information systems Human (Human), Organization, Technology and the benefits provided. With all four perspectives is expected to yield an appropriate evaluation to measure the success and influence of HIS implementation. This study will be tested to 213 HIS users by using questionnaires and interviews. The data collection technique is used to assess the effect of each perspective HOT FIT Model. Data will be analyzed quantitatively by using multiple regression. The results showed that 1) the impact on the use of User Satisfaction System, 2) use of the system positively affects user satisfaction. 3) Quality of information is User Satisfaction of positive influence. 4) Quality of Service is positive effect on User Satisfaction. 5) Quality Systems positive effect on Organizational Structure. 6) Quality of Service positive effect on Organizational Structure. 7) Environment Organization positive effect on Organizational Structure.
Evidence of a functional estrogen receptor in parathyroid adenomas.

CONTEXT Primary hyperparathyroidism (PHPT) is most frequently present in postmenopausal women. Although the involvement of estrogen has been suggested, current literature indicates that parathyroid tumors are estrogen receptor (ER) α negative. OBJECTIVE The aim of the study was to evaluate the expression of ERs and their putative function in parathyroid tumors. DESIGN A panel of 37 parathyroid tumors was analyzed for expression and promoter methylation of the ESR1 and ESR2 genes as well as expression of the ERα and ERβ1/ERβ2 proteins. Transcriptome changes in primary cultures of parathyroid adenoma cells after treatment with the selective ERβ1 agonist diarylpropionitrile (DPN) and 4-hydroxytamoxifen were identified using next-generation RNA sequencing. RESULTS Immunohistochemistry revealed very low expression of ERα, whereas all informative tumors expressed ERβ1 (n = 35) and ERβ2 (n = 34). Decreased nuclear staining intensity and mosaic pattern of positive and negative nuclei of ERβ1 were significantly associated with larger tumor size. Tumor ESR2 levels were significantly higher in female vs. male cases. In cultured cells, significantly increased numbers of genes with modified expression were detected after 48 h, compared to 24-h treatments with DPN or 4-hydroxytamoxifen, including the parathyroid-related genes CASR, VDR, JUN, CALR, and ORAI2. Bioinformatic analysis of transcriptome changes after DPN treatment revealed significant enrichment in gene sets coupled to ER activation, and a highly significant similarity to tumor cells undergoing apoptosis. CONCLUSIONS Parathyroid tumors express ERβ1 and ERβ2. Transcriptional changes after ERβ1 activation and correlation to clinical features point to a role of estrogen signaling in parathyroid function and disease.
A further analysis of the spatio‐temporal variability in aerosols across North America: Incorporation of lower tropospheric (850‐hPa) flow

In our previous research (Power et al., 2006), we analysed the variability in spectral aerosol optical depth (τa), as well as Ångström's wavelength exponent (α), which represents the relative size distribution of aerosols, at 27 sites across North America. The variability was assessed by incorporating the Spatial Synoptic Classification (SSC) surface weather type across each of these sites. In this research, we further our analysis by examining the effect of different 850‐hPa flow patterns within the lower troposphere on variability in τa and α. To accomplish this, an 850‐hPa flow classification was first developed from principal components analysis (PCA) and cluster analysis on National Centers for Environmental Prediction (NCEP)/The National Center for Atmospheric Research (NCAR) reanalysis geopotential‐height data, normalized by month of year. Nine flow types were identified.
A framework linking intangible resources and capabilities to sustainable competitive advantage

This article is concerned with the role of intangible resources in business strategy. In particular it is concerned with identifying the intangible sources of sustainable competitive advantage. Sustainable competitive advantage results from the possession of relevant capability differentials. Regulatory and positional capabilities are concerned with intangible assets; functional and cultural capabilities are concerned with competencies. A framework linking intangible resources to capabilities has been devised and is used as the basis of a new technique for identifying the relative contribution which the different intangible resources make to competitive advantage. The results of the use of this technique in six case studies are reported.
Industry Mindsets: Exploring the Cultures of Two Macro-Organizational Settings

Cultures are dynamic, shared mindsets that, in organizational settings, are usually believed to be nationally or organizationally based. In this paper, the existence of industry cultures is explored. Previous studies of industry-based cognitive constructs have narrowly focused on top managers' mental models for strategic decision making. Here, broad-based assumption sets comprising the cultural knowledge widely shared among organizational participants within two industries (fine arts museums and California wineries) are surfaced and compared. A cognitive definition of culture and a modified ethnographic methodology frame the inquiry. The research process balances the requirements of the inductive method with the logistics of doing research in settings as broad in scope as “industry” and into issues as amorphous as “culture in modern organizations. ” This process involves the selection and in-depth interviewing of 96 informants in 12 organizations, representing a cross-section of members of these two industries. The distinct assumption sets that surface for each industry demonstrate, among other things, substantial differences in conceptualizations of membership, competition, the origins of “truth,” the purpose of work, and the nature of work relationships. The findings suggest that the current narrow focus in research on industry-based cognitive constructs can be productively broadened to include a fuller range of cultural elements and a wider set of industry participants. The surfacing of distinct industry mindsets reinforces the emerging belief that a multiplicity of dynamic, shared mindsets exist within an organization's environment. A new cognitive lens—that of industry —is offered, through which scholars and managers alike can view behavior in organizational settings.
OF THE WEEK 253 5 TH MARCH 2012 Dr

4. Regarding the conduct of anaesthesia: a. 15 degrees left lateral tilt should be applied from 24 weeks gestation to prevent aortocaval compression b. Ephedrine is the vasopressor of choice. c. Fetal heart rate monitoring is a useful predictor of fetal wellbeing from 20 weeks gestation. d. Hyperventilation to manipulate PaCO2 and cerebral vascular tone should be within limits of 25-30 mmHg. e. Esmolol is an effective way to reduce pressor responses to laryngoscopy with no impact on fetal wellbeing.
Relationship Marketing Theory: Its Roots and Direction

This paper participates in the latest discussion on theory formation in the marketing discipline. We argue that some of the novelty and generality claims in current relationship-marketing (RM) propositions are inflated. On the basis of a conceptual analysis of the disciplinary roots of RM thinking, we argue that RM does not form a general theory of marketing, and that actually two types of relationship theory exist: Market-based, more consumer-oriented RM, and Network-based, more interorganisationally-oriented RM. The fundamental differences between these two types of theory are identified and discussed. Theoretical conclusions and managerial challenges originating from the dual nature of relationship marketing conclude the paper.
UPLC-QTOF-MS Identification of the Chemical Constituents in Rat Plasma and Urine after Oral Administration of Rubia cordifolia L. Extract

An effective ultra-performance liquid chromatography coupled with the quadrupole time-of-flight tandem mass spectrometry (UPLC/Q-TOF/MS) method was developed for analysing the chemical constituents in rat plasma and urine after the oral administration of Rubia cordifolia L. extract. Under the optimized conditions, nine of 11 prototypes in rat plasma and four prototypes in urine were identified or characterized by comparing the retention time, accurate mass, fragmentation patterns, reference compounds, and literature data. In total, six metabolites, including alizarin-1-O-β-glucuronide, alizarin-2-O-β-glucuronide, alizarin-1-O-sulfation, alizarin-2-O-sulfation, purpurin-1-O-β-glucuronide, and purpurin-3-O-β-glucuronide, were identified in rat plasma, which were confirmed by lavaging standard solutions. Purpurin was found to be able to be transformed into alizarin based on the results in which alizarin was detected in rat plasma after the oral administration of a purpurin solution. In total, four metabolites were found in rat urine, but their chemical structures were not confirmed. The results indicate that the metabolic pathway of alizarin involves glucuronidation and sulfation, with the purpurins having undergone glucuronidation. The components absorbed into the blood, and the metabolites have the opportunity to become bioactive constituents. The experimental results would supply a helpful chemical basis for further research on the mechanism of actions of Rubia cordifolia L.
Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial.

Noncardiac chest pain is associated with poor quality of life and high care expenditure. The majority of noncardiac chest pain is either gastresophageal reflux disease related or due to esophageal motility disorders, and the rest are considered functional chest pain (FCP) due to central and peripheral hypersensitivity. Current treatment of FCP improves 40-50% of patients. Cannabinoid receptors 1 (CB1) and 2 (CB2) modulate release of neurotransmitters; CB1 is located in the esophageal epithelium and reduces excitatory enteric transmission and potentially could reduce esophageal hypersensitivity. We performed a prospective study to evaluate its effects on pain threshold, frequency, and intensity in FCP. Subjects with FCP received dronabinol (5 mg, twice daily; n = 7; average age, 44 years; mean body mass index, 26.7) or placebo (n = 6; average age, 42 years; mean body mass index, 25.9) for 28 days (4 weeks). Chest pain, general health, and anxiety/depression questionnaires were assessed at baseline and at 4 weeks. Subjects underwent an esophageal balloon distention test prior to treatment and on last day of the study. Dronabinol increased pain thresholds significantly (3.0 vs. 1.0; P = 0.03) and reduced pain intensity and odynophagia compared to placebo (0.18 vs. 0.01 and 0.12 vs. 0.01, respectively, P = 0.04). Depression and anxiety scores did not differ between the groups at baseline or after treatment. No significant adverse effects were observed. In this novel study, dronabinol increased pain threshold and reduced frequency and intensity of pain in FCP. Further, large scale studies are needed to substantiate these findings.
Effect of gender on late-onset multiple sclerosis

Objectives: We aimed to examine the incidence and disease course of late-onset multiple sclerosis (LOMS) compared with adult-onset MS (AOMS) in our clinic cohort, stratified based on gender and race, since both have been reported as important modifiers of disease outcomes in MS. Methods: Patients with LOMS and AOMS were compared in terms of demographic characteristics and disease course characteristics. Combined effects were investigated with a logistic regression model. Time from disease onset to sustained Expanded Disability Status Scale (EDSS) score of 6 was investigated using an extension of log-rank test appropriate for interval-censored data. Results: Some 7.96% of 4273 patients studied had an onset of MS after the age of 50 years (LOMS), and 1.33% experienced an onset after age 60. Progressive onset was more common in LOMS relative to AOMS. The proportion of women with progressive-onset disease was similar in AOMS and LOMS. Time to EDSS 6 was delayed in AOMS females compared with males; however, it was similar between males and females in the LOMS group. Conclusions: Women with LOMS have a different trajectory in terms of disease progression than women with AOMS. The effect of menopause combined with race/ethnicity on the MS disease course requires further investigation.