Miracle-dz/UniFAR-FTUs huggingface dataset:
Repetition priming effects for famous faces through dynamic causal modelling of latency‐corrected event‐related brain potentials

Repetition priming, that is, the repeated processing of a stimulus, facilitates performance. However, the neural underpinnings of repetition priming for famous faces in terms of effective connectivity are not known. Here we investigated this problem using dynamic causal modelling of latency‐corrected event‐related brain potentials (RERPs). Source waveforms of RERP‐derived sources in the Occipital Lobe, Fusiform Gyrus, Mediotemporal Lobe, Prefrontal Cortex and Anterotemporal Lobe of each hemisphere entered into models with only forward (F) or also with backward (FB) connections. Based on the framework of predictive coding formulated for repetition suppression, modulations of F and FB connections were expected for sources that displayed priming effects in their source waveforms. Hence, neural sources in each hemisphere were fitted with either F or FB connections. Inter‐hemispheric connections were considered between homologous areas and were allowed to be modulated in an incremental manner resulting in a model space that comprised of 24 models. Bayesian model averaging across models revealed effective bidirectional connectivity between the Fusiform Gyrus (face perception) and Prefrontal Cortex (decision‐making) in both hemispheres to be modulated by priming. In the left hemisphere, there is also a substantial involvement from the Mediotemporal Lobe, indicating the facilitation of automatic retrieval of the famous person's name. Furthermore, there is evidence that the priming is supported by connections from the right to the left Fusiform Gyri possibly in the service of inter‐hemispheric cooperation. Altogether, the study indicates that along with top–down modulations, efficient processing within and across the two hemispheres is crucial for famous face priming.
Survival and quality of life after surgery for colorectal cancer in the elderly: a comparative study.

BACKGROUND the aim of this study was to analyze the clinical results of the multidisciplinary management of elderly patients with colorectal cancer in a single center and to describe postoperative quality of life. METHODS a comparative study was designed to compare the results and quality of life of patients treated in our center for colon cancer, aged from 80 to 84 years (study group) compared to a control group (aged form 75 to 79 years of age). Morbidity, mortality, oncological results and quality of life were analyzed. RESULTS eighty-seven patients aged between 80 and 84 years of age (study group) were compared to a control group, which was formed by 91 patients aged from 75 to 79 years of age. There were no significant differences in technique and morbidity. Survival at 30 days, 90 days and at the end of follow-up (median 48 months) were similar in both groups. There were no differences in quality of life except for one item with regard to physical function (p = 0.0138). CONCLUSION similar clinical results and quality of life were achieved after treating elderly patients with colon cancer with a multidisciplinary management approach.
MicroRNA‐7b attenuates ischemia/reperfusion‐induced H9C2 cardiomyocyte apoptosis via the hypoxia inducible factor‐1/p‐p38 pathway

MicroRNAs (miRNAs) have been shown to play crucial roles in the occurrence, development, and treatment of many cardiovascular diseases. Coronary heart disease (CAD)‐related miRNAs are still a growing research area. miR‐7b was reported to be downregulated in acute myocardial infarction (AMI) myocardium tissues. However, it remains largely unknown whether miR‐7b is involved in the pathogenesis and progression of the AMI ischemia/reperfusion (I/R) injury.
Asperyellone prevents HDF cells from UVB irradiation damages: An elaborated study

The current study explores the photo‐protective effect of asperyellone (AY) (a fungal secondary metabolite), assessed under in vitro condition using human dermal fibroblast cell line. AY was isolated from Aspergillus sp. during the resting phase and purified. The initial cytocompatibility assessment on concentrations of AY and the duration of exposure of UVB irradiations were studied respectively. N‐acetyl‐L‐cysteine (NAC) was used as positive control. Cells were then pretreated with optimized concentration of AY (2.0 μM) and NAC (1 mM) for 1 hour and then UVB irradiated (30 mJ/cm 2) for the period of 10 minutes. Results revealed that reactive oxygen species generated upon UVB irradiation found scavenged by the AY pretreatment at a significant level. Furthermore, an appreciable reduction in apoptotic cell count and DNA damages support the scavenging effect of AY. Assessments on the expression of enzymatic and nonenzymatic antioxidants evidently prove the protective role of AY. The reduced expression levels of inflammatory markers (TNF‐α and COX‐2), collagen degraders (MMP 2 and MMP 9), apoptotic protein expressions (Bax and Bcl‐2), and cell‐cycle arrest analyses substantiate the photo‐protective effect of AY similar to NAC (positive control). Thus, the observations made in the current study indicate the possible role of AY as a photo‐protective agent.
The history of Basque

Basque is the sole survivor of the very ancient languages of Western Europe. This book, written by an internationally renowned specialist in Basque, provides a comprehensive survey of all that is known about the prehistory of the language, including pronunciation, the grammar and the vocabulary. It also provides a long critical evaluation of the search for its relatives, as well as a thumbnail sketch of the language, a summary of its typological features, an external history and an extensive bibliography.
Participation in a population-based screening for colorectal cancer using the faecal immunochemical test decreases mortality in 5 years

Background The steady increase in colorectal cancer (CRC) could be reversed through timely secondary prevention (screening) as a main strategy. The aims of this study were to determine the main features of CRC, survival rate and related factors for different types of identified CRCs in a population-based screening programme using the faecal immunochemical test (FIT). Materials and methods The CRCs in the susceptible population to be screened between 2009 and 2014 were identified and classified into four groups: (a) nonscreening-detected CRC (diagnosed before first screening invitation and nonparticipants), (b) screening-detected CRC, (c) interval cancer (IC) FIT (diagnosed between screening rounds after a negative FIT) and (d) IC colonoscopy (diagnosed before the colonoscopy surveillance, which is recommended after the screening colonoscopy). Patient demographics and epidemiological characteristics, tumour characteristics and survival were compared between the four groups. Results 5909 individuals were diagnosed with a CRC. The median follow-up of survival was 4.6 years (range: 0–9 years). The study highlights a significant difference (P<0.0001) in the 5-year survival in the screening-detected CRC group compared with those who had nonscreening-detected CRCs (90.1 vs. 66.7%). Although ICs are not desirable events, the 5-year survival rate is significantly higher with respect to nonparticipants (P<0.0001) (76.3 vs. 60.5%), this being the group with the lowest survival rate. Conclusion The significantly higher 5-year survival rate of 23.4% of the participants in the screening programme suggests that incidence and mortality rates of CRC will decrease in the near future for participants in screening programmes. A high participation rate is essential to achieve health benefits, irrespective of the type of participation.
Moderate and severe household food insecurity predicts stunting and severe stunting among Rwanda children aged 6-59 months residing in Gicumbi district.

Household food insecurity (HFI) plays an important role in child malnutrition in many low-income countries. We determined the association between HFI and stunting and severe stunting among Rwandan children from the Gicumbi district, aged 6-59 months using a cross-sectional study of 2,222 children. HFI factor was calculated by summing all seven HFI (access) frequency questions and was categorised into food security, mildly food insecurity, moderately food insecurity, and severe food insecurity. The association between stunting, severe stunting, and HFI was determined using the multiple logistic regression analyses that adjust for clustering and sampling weights. The odds of moderate and severe HFI were significantly higher among stunted children aged 6-59 months than those who were not stunted (adjusted odds ratio [AOR] = 1.43; 95% confidence interval [CI] [1.11, 1.84] and AOR = 1.35; 95% CI [1.08, 1.69], respectively). Children from households with moderate food insecurity were 2.47 times more likely to be severely stunted (AOR = 2.47; 95% CI [1.77, 3.46]), and those from households with severe food insecurity were more likely to be severely stunted (AOR = 1.82; 95% CI [1.34, 2.48]), compared with children aged 6-59 months from households with food security. Other factors included male children and children who did not attend monthly growth monitoring sessions. This study showed that moderate and severe HFI correlated with stunting and severe stunting. Interventions to improve stunting in Gicumbi children should also focus on male children, children who did not attend monthly growth monitoring sessions, and households with moderate and severe food insecurity.
Sharpening the focus on ophthalmology teaching: has anything changed?

In 1992, Justin O’Day wrote an editorial in this journal, then called the Australian and New Zealand Journal of Ophthalmology, highlighting the importance of undergraduate ophthalmology teaching. In the same edition, Stark et al. published a review of ophthalmology in the undergraduate curriculum in Queensland, calling for ophthalmology to be taught as a separate discipline and for the time allocated to it to be lengthened. In 2007, Fan et al. reported the results of a survey on undergraduate ophthalmology teaching in Australasian and Asian medical schools, concluding that, despite established international ophthalmology curriculum guidelines, ophthalmology may increasingly be a small, or even absent, component of undergraduate medical curricula. There was an associated editorial and several letters to the editor, indicating that there was considerable interest in this issue. Now, the publication of Zhang et al.’s findings on perceptions of medical students and junior medical officers prompts yet another pause for reflection. What has not changed and why? What has changed and how? What needs to change and how can we ensure this happens? First and most importantly, the educational need has not changed. Second, the findings of Zhang et al. confirm that the status of ophthalmology teaching to undergraduates remains stubbornly suboptimal or even inadequate. Some of the cited reasons for this include:
Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (e.g. chronic thromboembolic PH and pulmonary veno-occlusive disease). However, PH remains an incurable condition with a high mortality rate, underscoring the need for a better transfer of novel scientific knowledge into healthcare interventions. Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post-capillary involvement of pulmonary vessels) and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of PH. We also discuss ways to improve management and to support and optimise drug development in this research field. State of the art and research perspectives in the cellular and molecular basis and pathology of pulmonary vascular remodelling associated with various forms of pulmonary hypertension http://ow.ly/cjwp30mgzmH
A novel Staphylococcus aureus cis–trans type I toxin–antitoxin module with dual effects on bacteria and host cells

Abstract Bacterial type I toxin–antitoxin (TA) systems are widespread, and consist of a stable toxic peptide whose expression is monitored by a labile RNA antitoxin. We characterized Staphylococcus aureus SprA2/SprA2AS module, which shares nucleotide similarities with the SprA1/SprA1AS TA system. We demonstrated that SprA2/SprA2AS encodes a functional type I TA system, with the cis-encoded SprA2AS antitoxin acting in trans to prevent ribosomal loading onto SprA2 RNA. We proved that both TA systems are distinct, with no cross-regulation between the antitoxins in vitro or in vivo. SprA2 expresses PepA2, a toxic peptide which internally triggers bacterial death. Conversely, although PepA2 does not affect bacteria when it is present in the extracellular medium, it is highly toxic to other host cells such as polymorphonuclear neutrophils and erythrocytes. Finally, we showed that SprA2AS expression is lowered during osmotic shock and stringent response, which indicates that the system responds to specific triggers. Therefore, the SprA2/SprA2AS module is not redundant with SprA1/SprA1AS, and its PepA2 peptide exhibits an original dual mode of action against bacteria and host cells. This suggests an altruistic behavior for S. aureus in which clones producing PepA2 in vivo shall die as they induce cytotoxicity, thereby promoting the success of the community.
Mapping the terrain : new genre public art

Anthology edited by Lacy, focusing on "new genre public art." Essays by 11 authors situate community-responsive and audience-directed art practices within diverse socio-political and art historical contexts. Emphasis is place on how relational, participatory and interactive art strategies respond to the institutional framework of art. Other topics discussed include: the social relevance of art; artist's reponsibility; non-museum-oriented forms of beauty; the value of collaboration; differences between community-oriented art and public art. Includes compendium of more than 80 artists working in the field. Biographical notes. Circa 110 bibl. ref.
Getting into Shape: Limb Bone Strength in Perinatal Lemur catta and Propithecus coquereli

Functional studies of skeletal anatomy are predicated on the fundamental assumption that form will follow function. For instance, previous studies have shown that the femora of specialized leaping primates are more robust than those of more generalized primate quadrupeds. Are such differences solely a plastic response to differential loading patterns during postnatal life, or might they also reflect more canalized developmental mechanisms present at birth? Here, we show that perinatal Lemur catta, an arboreal/terrestrial quadruped, have less robust femora than perinatal Propithecus coquereli, a closely related species specialized for vertical clinging and leaping (a highly unusual locomotor mode in which the hindlimbs are used to launch the animal between vertical tree trunks). These results suggest that functional differences in long bone cross‐sectional dimensions are manifest at birth, belying simple interpretations of adult postcranial form as a direct record of loading patterns during postnatal life. Despite these significant differences in bone robusticity, we find that hindlimb bone mineralization, material properties, and measures of whole‐bone strength generally overlap in perinatal L. catta and P. coquereli, indicating little differentiation in postcranial maturity at birth despite known differences in the pace of craniodental development between the species. In a broader perspective, our results likely reflect evolution acting during prenatal ontogeny. Even though primates are notable for relatively prolonged gestation and postnatal parental care, neonates are not buffered from selection, perhaps especially in the unpredictable and volatile environment of Madagascar. Anat Rec, 2018. © 2018 Wiley Periodicals, Inc. Anat Rec, 303:250–264, 2020. © 2018 American Association for Anatomy
Bone marrow endothelial cells sustain a tumor-specific CD8+ T cell subset with suppressive function in myeloma patients

ABSTRACT Endothelial cells (EC) line the bone marrow microvasculature and are in close contact with CD8+ T cells that come and go across the permeable capillaries. Because of these intimate interactions, we investigated the capacity of EC to act as antigen-presenting cells (APC) and modulate CD8+ T cell activation and proliferation in bone marrow of patients with multiple myeloma (MM) and monoclonal gammopathy of undetermined significance. We found that EC from MM patients show a phenotype of semi-professional APC given that they express low levels of the co-stimulatory molecules CD40, CD80 and CD86, and of the inducible co-stimulator ligand (ICOSL). In addition, they do not undergo the strong switch from immunoproteasome to standard proteasome subunit expression which is typical of mature professional APC such as dendritic cells. EC can trap and present antigen to CD8+ T cells, stimulating a central memory CD8+ T cell population that expresses Foxp3 and produces high amounts of IL-10 and TGF-β. Another CD8+ T cell population is stimulated by professional APC, produces IFN-γ, and exerts antitumor activity. Thus, two distinct CD8+ T cell populations coexist in the bone marrow of MM patients: the first population is sustained by EC, expresses Foxp3, produces IL-10 and TGF-β, and exerts pro-tumor activity by negatively regulating the second population. This study adds new insight into the role that EC play in MM biology and describes an additional immune regulatory mechanism that inhibits the development of antitumor immunity and may impair the success of cancer immunotherapy.
Predicting return to work after acute myocardial infarction: Socio-occupational factors overcome clinical conditions

Objectives Return to work after acute myocardial infarction (AMI), a leading cause of death globally, is a multidimensional process influenced by clinical, psychological, social and occupational factors, the single impact of which, however, is still not well defined. The objective of this study was to investigate these 4 factors on return to work (RTW) within 365 days after AMI in a homogeneous cohort of patients who had undergone an urgent coronary angioplasty. Participants We studied 102 patients, in employment at the time of AMI (88.24% of men), admitted to the Department of Cardiology of the University-Hospital of Ferrara between March 2015 to December 2016. Demographical and clinical characteristics were obtained from the cardiological records. After completing an interview on social and occupational variables and the Hospital Anxiety and Depression (HADS) questionnaire, patients underwent exercise capacity measurement and spirometry. Results Of the 102 patients, only 12 (12.76%) held a university degree, 68.63% were employees and 31.37% self-employed. The median number of sick-leave days was 44 (IQR 33–88). At day 30, 78.5% of all subjects had not returned to work, at day 60, 40.8% and at day 365 only 7.3% had not resumed working. At univariate analyses, educational degree (p = 0.026), self-employment status (p = 0.0005), white collar professional category (p = 0.020) and HADS depression score were significant for earlier return to work. The multivariate analysis confirms that having a university degree, being self-employed and presenting a lower value of HADS depression score increase the probability of a quicker return to work. Conclusions These findings suggest that the strongest predictors of returning to work within 1 year after discharge for an acute myocardial infarction are related more to socio-occupational than to clinical parameters.
In Vitro and In Vivo Functional Characterization of Essence of Chicken as An Ergogenic Aid

Essence of chicken is a popular Asian nutritional supplement that is often taken to improve metabolism and general health. Although used as a traditional remedy for combating fatigue and general health, there has been few studies investigating the ergogenic properties of chicken essence and its associated mechanism. We conducted a study to investigate the anti-fatigue and anti-oxidant properties of essence of chicken (EC) after exercise. Six weeks old male Institute of Cancer Research (ICR) mice were divided to four groups (10 mice/group) and were provided different doses of Essence of Chicken (EC): (1) Vehicle (water), (2) EC-0.5X (558 mg/kg), (3) EC-1X (1117 mg/kg), and (4) EC-2X (2234 mg/kg). EC supplementation could improve endurance and grip strength (p < 0.0001) and it had significant effects on the fatigue-related biochemical markers: ammonia, blood urea nitrogen (BUN), and creatine kinase (CK) levels were significantly lowered, while glucose blood levels and lactate clearance were improved after exercise challenge. Muscle and liver glycogen levels, muscle and liver superoxide dismutase (SOD), hepatic catalase (CAT), and glutathione (GSH) levels were observed to increase with EC supplementation. Preliminary in vitro data suggests that EC may have a beneficial effect in muscle mass and strength. No abnormalities were observed from pathohistological examination. Our study suggests that the EC could significantly improve exercise performance and endurance capacity and that the anti-oxidant properties of EC may be an important contributing factor to its anti-fatigue effects.
Environmental conditions affecting re‐release from particulate matter of 4‐Nonylphenol into an aqueous medium

4‐nonylphenol is a persistent organic pollutant with endocrine‐disrupting properties. A nonpolar product of microbial degradation derived from the surfactant nonylphenol polyethoxylate, 4‐nonylphenol is capable of long‐range transport attached to particulates. Bioactive concentrations of 4‐nonylphenol have been found in the surface water, soils, snow, and particulate matter of the Eastern Sierra Nevada Mountains (USA) hundreds of miles from their origins. As a result of particulate deposition, seasonal and glacial snow pack concentrations measured 20 to 100 times higher than in surface waters. Batch desorption assays were run on particulate matter dosed with 4‐nonylphenol. Desorption was measured in 63 to 500 μm particles under 2 different temperature conditions with varying fractions of organic carbon in turbulent or undisturbed states. Lower temperatures (4 °C) decreased the mean percentage of 4‐nonylphenol released from particulates in disturbed and undisturbed conditions, whereas the mean percentage of 4‐nonylphenol released at 20 °C was reduced by agitation. The effect of agitation at 4 °C was not practically or statistically significant. Particulates with a higher percentage of organic carbon (75%) released very little of the bound 4‐nonylphenol (0.53%) compared with particulates containing 4 to 5% of organic carbon that released up to 13%. Larger particles released the least amount of 4‐nonylphenol, whereas smaller particles released the most amount. Water and sediment samples taken from below the Palisades Glacier in the Sierra Nevada Mountains showed the greatest 4‐nonylphenol concentrations directly below the glacier, implying that glacial particulates will release adsorbed 4‐nonylphenol. Environ Toxicol Chem 2019;38:350–360. © 2018 SETAC