Miracle-dz/UniFAR-FTUs huggingface dataset:
Immediate loading of fixed provisional prostheses using four implants for the rehabilitation of the edentulous arch: a prospective clinical study.

PURPOSE The purpose of this prospective clinical trial was to evaluate over a 5-year period the treatment outcomes for immediately loaded full-arch fixed prostheses supported by two axially inclined and two tilted implants used to rehabilitate edentulous arches. This report presents preliminary 1-year results. MATERIALS AND METHODS Thirty-seven patients were recruited for treatment with either mandibular or maxillary full-arch fixed prostheses supported by four implants. Within 24 hours, the implants were immediately loaded with screw-retained full-arch acrylic resin provisional restorations. Definitive reconstructions were delivered 6 months later. Complete full-arch prostheses were supported by metal frameworks combined with high-density acrylic resin. Follow-up visits were scheduled for 6 and 12 months after initial prosthetic loading and then annually for up to 5 years. Digital radiographs were obtained immediately, 6 months after surgery, and at each annual follow-up visit. Marginal peri-implant bone levels were assessed using digital image analysis. RESULTS The 1-year implant survival rates were 96.0% for axially positioned implants and 94.6% for tilted implants. The survival rates were 96.6% for maxillary implants and 98.7% for mandibular implants. The prosthetic survival rate was 100%. No significant differences were found in the results for tilted versus axially positioned implants. One year after loading, the mean marginal bone loss was 0.82 ± 0.31 mm around the axially oriented implants and 0.76 ± 0.49 mm around the tilted implants (P ⋜ .05). CONCLUSIONS Preliminary data from this clinical trial show high implant survival rates for immediately loaded full-arch prostheses supported by four implants. Immediate loading of tilted implants may be considered a viable treatment option for the rehabilitation of edentulous patients.
Bronchial artery embolization to control hemoptysis: comparison of N-butyl-2-cyanoacrylate and polyvinyl alcohol particles.

PURPOSE To retrospectively compare safety and effectiveness of embolic agents polyvinyl alcohol (PVA) particles versus n-butyl-2-cyanoacrylate (NBCA) for bronchial artery embolization (BAE) for control of hemoptysis. MATERIALS AND METHODS Institutional review board approved this retrospective study; informed consent was waived. From January 2005 to December 2008, 406 patients (242 men, 164 women; age range, 6-92 years) with major hemoptysis underwent BAE by using PVA particles (n = 293) or NBCA (n = 113). Technical and clinical success, complications, hemoptysis-free survival rates, and causes of recurrent hemoptysis were compared between PVA and NBCA groups. The differences in hemoptysis-free survival rates were assessed between subgroups stratified to underlying diseases. The predictive factor for recurrent hemoptysis was identified with Cox proportional hazard regression model. RESULTS Technical success was achieved in 93.9% (275 of 293) and 96.5% (109 of 113) of patients for PVA and NBCA, respectively (P = .463); clinical success was achieved in 92.2% (270 of 293) and 96.5% (109 of 113) of patients for PVA and NBCA, respectively (P = .180). Overall and major complication rates were not statistically different (overall complication rates: 34.1% for PVA, 31.0% for NBCA; P = .56; major complication rates: 0.3% for PVA, 0% for NBCA; P > .999). The 1-, 3-, and 5-year hemoptysis-free survival rates were, respectively, 77%, 68%, and 66% for PVA and 88%, 85%, and 83% for NBCA (P = .01). Recanalization of previously embolized vessels was more frequent in PVA group (21.5%) than in NBCA group (1.8%; P < .001). NBCA group showed hemoptysis-free survival rates superior to PVA group in patients with bronchiectasis (P = .016). PVA (P = .050) and aspergilloma (P < .001) were predictive factors for recurrent hemoptysis. CONCLUSION BAE with NBCA provided higher hemoptysis-free survival rates compared with PVA particles without increasing complication rates. This improvement was evident in patients with bronchiectasis and was caused by more durable embolic effect than PVA particles. SUPPLEMENTAL MATERIAL http://radiology.rsna. org/lookup/suppl/doi:10.1148/radiol.13130046/-/DC1.
A descriptive analysis of the perceptions of North Carolina 4-H agents toward minority youth participation in agricultural-related activities.

An analysis of the perceptions of North Carolina 4-H Extension personnel regarding minority youth participation in agriculture-related activities was conducted. Based on the data collected, the researchers found that 4-H agricultural programs were not fully meeting the needs of a growing diverse population. There is a strong need to improve agricultural program participation in order to increase recruitment and retention strategies for minority youth in relation to 4-H agricultural based activities.
Gate-All-Around Junctionless Transistors With Heavily Doped Polysilicon Nanowire Channels

In this letter, we have investigated experimentally, for the first time, the feasibility of gate-all-around polycrystalline silicon (poly-Si) nanowire transistors with junctionless (JL) configuration by utilizing only one heavily doped poly-Si layer to serve as source, channel, and drain regions. In situ doped poly-Si material features high and uniform-doping concentration, facilitating the fabrication process. The developed JL device exhibits desirable electrostatic performance in terms of higher ON/OFF current ratio and lower source/drain series resistance as compared with the inversion-mode counterpart. Such scheme appears of great potential for future system-on-panel and 3-D IC applications.
Entrepreneurship Education In The Context Of Developing Countries: Study Of The Status And The Main Barriers In Mozambican Higher Education Institutions

This study focuses on the issue of entrepreneurship education and the role of Higher Education Institutions (HEI) in the context of developing countries. More specifically it aims to understand how entrepreneurship education is being implemented in Mozambique and to identify the main barriers to the creation of companies promoted by/incubated in HEI with entrepreneurship education in their curricula. The paper includes theoretical discussion and the presentation of a case study. It begins with a literature review about the relationship between entrepreneurship and development followed by a discussion about entrepreneurship education in the context of developing countries and entrepreneurship education provided by HEI. The empirical study is focused in Mozambique. After a contextualization of entrepreneurship education in Mozambique, Mozambican HEI with entrepreneurship education are identified and their situation and difficulties concerning the implementation of entrepreneurship education are discussed. Data collection includes documental sources and interviews with HEI representatives of a sample of ten establishments of the universe of five public and private HEI with entrepreneurship education in Mozambique. Results indicate that lack of resources, trained/qualified teachers and cooperation networks with the business community and other relevant actors are the main barriers.
Struggling with Meaningfulness When Context Shifts: Volunteer Work in a German Refugee Shelter

This article draws on an ethnographic study of volunteer work in a German refugee shelter to explore how individual experiences of meaningfulness are intertwined with shifting discursive and organisational contexts. At the beginning of the so‐called refugee crisis, societal discourses portrayed this volunteer work as extraordinarily meaningful – a state we capture through the metaphor of ‘overflow’. This ‘overflow’ mobilised volunteers and was an important point of reference for framing their work experiences as meaningful. Later, shifting discursive and organisational contexts challenged their framings. Instead of letting go, however, the ‘overflow’ triggered volunteers to reframe their experience in dysfunctional ways in order to sustain their sense of meaningfulness. This paper reveals how shifting societal discourses feed into individual experiences of meaningfulness, shows how individuals may respond to such shifts in problematic ways and theorises the nature of such shifts in drawing on Swidler’s notion of settling contexts.
Two for the price of one: a bifunctional intron-encoded DNA endonuclease-RNA maturase.

Homing endonucleases are enzymes that are typically encoded by intervening sequences of various kinds—introns that splice at the RNA level, or inteins that splice at the protein level (for review, see Belfort et al. 2002). The endonucleases function primarily to mobilize these elements, which are often self-splicing, by facilitating their integration to new sites in DNA. Because these sites are most often allelic intronless or inteinless sites, this form of mobility is termed homing, and the target sequences are termed homing sites. Homing endonucleases sometimes do double duty, also functioning as maturases, which promote RNA splicing (for review, see Lambowitz and Perlman 1990; Lambowitz and Belfort 1993). Maturases are usually intron specific, and act as cofactors that bind their introncontaining precursor RNA to facilitate splicing. Nevertheless, catalysis required for splicing remains a property of the RNA.
Reconstruction of large nasal septal perforations with a three layer galeal pericranial flap: an anatomical and technical study.

OBJECTIVES In this study, a modified surgical method was carried out to repair large nasal septal perforations with a galeal pericranial flap using endoscopic technique. MATERIALS AND METHODS Six adult human cadavers were dissected by applying the classic open rhinoplasty technique. Large perforations were created in the septal cartilages. To repair the perforations, we prepared galeal pericranial flaps with supraorbital neurovascular pedicles and calvarial bone grafts under endoscopic visualization. The flaps were inserted between the upper lateral cartilages and folded into three layers. The flaps were sutured to the nasal mucosa with absorbable sutures. The length, the width, the size of the flaps and the perforations were measured using an electronic caliper and a flexible ruler. RESULTS The mean length and width of the flap pedicles were measured as 26.8±5.1 mm (range 20 to 32 mm) and 19.3±2.6 mm (range 15 to 23 mm), respectively. In addition, the mean length and the width of the flaps were 54.1±4.9 mm (range 50 to 60 mm) and 51.6±7.8 mm (range 45 to 63 mm), respectively. All of the nasal septal perforations were repaired with a galeal pericranial flap. CONCLUSION The galeal-pericranial flap is well-vascularized and similar to the nasal mucosa for tissue thickness. Therefore, reconstruction with galeal-pericranial flaps can be an alternative surgical technique for repair of large nasal septal perforations.
Determinants of housing preferences in old age in Spain

Ageing and disability at old age give rise to new housing needs that can influence individual choice of living environment and preference to undertake housing improvements. Empirical evidence on housing preferences in old age is essential for policy design (especially in Spain with low coverage for long-term care and culture of property). In this study we undertake an em pirical analysis of the underlying behavioural determinants of housing preferences in old age in the event of dependency and physical impairment. It draws upon a new representati ve database of the Spanish population in order to estimate the extent to which preferences for housing characteristics are likely to change in old age, and the nature of those preferences. The study finds that old age, prefer to live at home even in the case of old-age dependency and this is so the older they become. People with less wealth but more savings and/or greater dependency needs are more likely to opt for institutional care, wh ilst people with lesser education, affluence and care (not cure) needs would prefer to live with their relatives.
Hybrid hypergraph construction for facial expression recognition

In this paper, we proposed a novel framework for facial expression recognition, in which face images were taken as vertices in a hypergraph and the task of expression recognition was formulated as the problem of hypergraph based inference. A hybrid strategy was developed to construct hyperedges: we generated probabilities of facial action units by deep convolutional networks and took each action unit as an ‘attribute’ to represent a hyperedge; we also formed hyperedges by using embedded network features before the last full connected layer to perform local clustering. In this way, each face image was assigned to various hyperedges by exploiting the representational power of deep convolutional networks. Our facial expression recognition system generates expression labels by a hypergraph based transductive inference approach, which tends to assign the same label to vertices that share many incidental hyperedges, with the constraints that predicted labels of training images should be similar to their ground truth labels. We compared the proposed approach to state-of-the-art methods and its effectiveness was demonstrated by extensive experimentation.
Incentives and Restrictions in Venture Capital Contracts

In venture capital markets, contracts between investors and enterprises stipulate special incentives and restrictions in order to address the occurrence of severe asymmetric information, to reduce investor risk, and to facilitate successful exits. The purpose of this paper is to provide an overview of the international literature on venture capital contracts with a primary focus on empirical aspects, and to compare the authors’ findings with the Hungarian practice as reflected in the questionnaire-based survey conducted among venture capital funds. We concentrated our research on management control rights, the application of convertible debt, cash flow rights, voting rights, and drag-along and tag-along rights. In the article we describe the key features of venture capital contracts, the characteristics of selected contract elements and their impact on corporate operations and the contracting parties. After the presentation of individual contract elements, we summarise the relevant empirical evidence of international papers and draw conclusions in light of the Hungarian contracting practice.
The Swedish Total Hip Replacement Register

Epidemiology of Primary and Revision Total Hip Replacement Introduction he Swedish Total Hip Replacement Register was initiated in 1979. The mission of the Register is to improve the outcome of total hip replacement (THR). Information technology development has substantially facilitated the possibility of fulfilling this mission. During the past three years, almost all information exchange between the reporting units and the Register has been provided via the Internet. Feedback to and reports from the participating units are effected through a specific website (www.jru.orthop.gu.se). The importance of the Register and its effect on quality improvement over time have been well documented. The hypothesis for the project is that feedback of analyzed data stimulates the individual clinic to reflect and improve according to the principle of the good example. The clinical and socioeconomic effects of the past twenty years of Register work have been striking, and almost fifty quality registries have been started in different medical fields in Sweden during the last decade.
β-Catenin is important for cancer stem cell generation and tumorigenic activity in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors with poor prognosis and recurrence in South China. The hard eradication of NPC in clinic is predominantly due to cancer stem cells (CSCs). Increasing evidence revealed that the aberrant activation of Wnt/ β -catenin was positively correlated with the produce of CSCs. To further investigate the effect of β -catenin on CSCs and tumorigenesis in NPC, a CNE2 cell line (pLKO.1-sh- β -catenin-CNE2) with stably suppressed expression of β -catenin was used in this study. The expressions of biomarkers in CSCs including c-myc, Nanog, Oct3/4, Sox2, EpCAM as well as adhesion-related proteins like E-cadherin and vimentin were analyzed by western blot analysis and immuno ﬂ uorescent staining. The proliferation and migration abilities were investigated by MTT assay and Transwell assay, respectively. Cell cycle was analyzed by ﬂ ow cytometry. Finally, xenograft was performed to determine the effect of β -catenin on oncogen-esis in vivo . Results showed that the expressions of c-myc, Nanog, Oct3/4, Sox2, and EpCAM were all decreased in pLKO.1-sh- β -catenin-CNE2 cells. It was also found that vimentin was downregulated, while E-cadherin was upregulated. Results of MTT and Transwell assays suggested that the proliferation and migration abilities were impaired by silencing of β -catenin, and more cells were arrested in G1 phase when compared with the control. In vivo study indicated that the tumor growth was mark-edly suppressed in experimental group. Based on current ﬁ ndings, β -catenin may function as an essential protein for the maintenance of migration and proliferation abilities of NPC cells, and a complicated network consisting of c-myc, Nanog, Oct3/4, Sox2, EpCAM, E-cadherin, vimentin, and β -catenin may be involved in the inherent regulation mechanisms. by accumulation of endogenous was for the characteristics of that as an indispensable for the maintenance of and proliferation abilities in CSC in to the CSC by downregulated the inhibitory effect on CSC was presumably by a comprehensive signal network consisting of c-myc, E-cadherin, and It has proposed may be a promising target for tumor therapy, and the anti-tumor effect of reduced expression of β was veri ed in in this of ﬁ c inhibitors of and drugs
Personnel Management by Whose Objectives

Public personnel management, as a field of public administration, has undergone considerable development in the past 40 years. Personnel professionals now have available a wide range of techniques which they can apply toward the efficient acquisition, allocation, and development of human resources-human resource planning, job analysis, selection, appraisal, training, and labor-management relations. The rapid development of these techniques signifies the increasing acceptance of rational, scientific problem-solving over previous methods of dealing with employees. However, the advance of rational personnel management has occurred at a cost: by emphasizing the "one best way" to complete a task, personnel professionals have ignored the diversity that exists in reality. Specifically, they have tended to overlook the impact that different organizational objectives and environments have on the effectiveness of personnel management techniques. As a result, many consequences of personnel techniques which affect employees, organization and environment are defined as falling outside the study and practice of personnel management. Ideas and concepts drawn from the literature of organization theory and administrative behavior furnish the opportunity to develop a dynamic and realistic view of personnel management. We approach the problem of developing a new theoretical framework in three segments:
Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells*

Extracellular cysteine cathepsins are known to drive cancer progression, but besides degradation of extracellular matrix proteins little is known about their physiological substrates and thus the molecular mechanisms they deploy. One of the major mechanisms used by other extracellular proteases to facilitate cancer progression is proteolytic release of the extracellular domains of transmembrane proteins or ectodomain shedding. Here we show using a mass spectrometry-based approach that cathepsins L and S act as sheddases and cleave extracellular domains of CAM adhesion proteins and transmembrane receptors from the surface of cancer cells. In cathepsin S-deficient mouse pancreatic cancers, processing of these cathepsin substrates is highly reduced, pointing to an essential role of cathepsins in extracellular shedding. In addition to influencing cell migration and invasion, shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase activity, thereby providing a putative mechanistic link between extracellular cathepsin activity and cancer progression. The MS data is available via ProteomeXchange with identifier PXD002192.
The Puzzle of Non-Participation in Training - an Empirical Study of Permanent vs. Occasional Non-Participation

Participation in continuing vocational training is often found to be associated with considerable individual benefits such as a wage increase or a reduction in unemployment. But why then do some participate and others don't? In our paper we argue that it is important to take selection effects into account in order to solve this puzzle. It is well known that training participants and non-participants differ in observable as well as in unobservable characteristics. The novel part in our paper is that we are able to show that even non-participants cannot be treated as a homogeneous group: there are individuals never taking part in training (permanent non-participants) and individuals currently (in a given year) not taking part (occasional non-participants). Previous empirical studies neglected these distinctions - mostly due to data restrictions. Our study fills this gap. It is based on a unique data set covering a large number of individuals not taking part in training, i.e., permanent and occasional non-participants. Comparing those two groups we find that permanent non-participants would have higher costs in case of participation than occasional non-participants. Moreover, the benefits associated with their current jobs would be lower, i.e., their pay increase and the reduction of their risk to get laid off would be smaller. Given these results their decision never to take part in training may be rational in a steady economic situation but it is not in times of rapid technological change because of better long-term employment outlooks due to better alternatives to change jobs. Our results indicate that in the long-run even permanent never-participants would benefit from participation in terms of improved prospects on the labor market. This indicates that permanent non-participants either misperceive future developments or suffer from an exceptionally high discount rate which in turn leads to a negative cost-benefit ratio of training in their perception.
Functional significance of cumulus expansion in the mouse: Roles for the preovulatory synthesis of hyaluronic acid within the cumulus mass

Gonadotropin‐stimulated expansion of the mouse cumulus oocyte complex (COC) in vitro, measured with a quantitative videographic method, is comparable to that observed to occur in vivo when medium is supplemented with porcine follicle stimulating hormone (pFSH), 10% fetal bovine serum (FBS), and 2.5 mM glucosamine or optimal concentrations of glutamine and glucose. In the absence of glucosamine, the volumetric expansion of COCs in vitro is never more than 25% of that occurring in its presence. The addition of 6‐diazo‐5‐oxo‐1‐norleucine (DON), an inhibitor of glucosamine synthesis to medium supplemented with glutamine and glucose, completely inhibits cumulus expansion in vitro. This system was utilized to examine the relationship between cumulus expansion and fertilization rates, and the maintenance of fertilizability in culture. Successful fertilization (as determined by development to the 2‐cell stage) was correlated with the quantity and quality of the expanded cumulus mass, and conversely, the spontaneous loss or mechanical removal of the cumulus was correlated with a loss of fertilizability following additional incubation in culture medium. In addition, the i.p. injection of DON inhibited cumulus expansion within the intact follicle and suppressed ovulation. © 1993 Wiley‐Liss, Inc.