Miracle-dz/UniFAR-FTUs huggingface dataset:
A case of non-episodic angioedema with eosinophilia induced by influenza vaccine

Angioedema with eosinophilia (AE) is characterized by hypereosinophilia in peripheral blood, angioedema, fever, and weight gain [1-3]. AE is triggered by various factors, including infection and drugs [1-3]. It is classified as nonepisodic AE (NE-AE) or episodic AE (E-AE) [1, 2]. We report a rare case of NE-AE induced by influenza vaccination. A 52-year-old Japanese woman developed fever (37.5◦C) and mild oedema over her whole body two hours after receiving vaccination against influenza virus. She had been receiving the same vaccination for the last 10 years, with no side effect. Although she was treated with an antipyretic/analgesic drug, mild fever persisted and the oedema gradually worsened. Therefore, she was admitted to our hospital seven days after the vaccination. Physical examination revealed oedema all over her body (figure 1A), which was more pronounced on her extremities. Laboratory work-up revealed significantly elevated white blood cell (WBC) count (21,880/ L) and mild liver dysfunction. Histopathological examination at the first medical examination revealed mild dermal oedema and a perivascular
Safety of Antidepressant Drugs in the Patient with Cardiac Disease: A Review of the Literature

Patients with cardiac disease, specifically ischemic heart disease and heart failure, have a higher frequency of major depressive disorder than patients without cardiac disease. The pathophysiologic reason for this is not completely understood. Previous depression, other debilitating illnesses, and type A personality are risk factors for the development of depression in cardiac patients. Depression has been shown to lower the threshold for ventricular arrhythmias. Therefore, treatment of depression potentially may prolong life in these patients. Antidepressant options that have been evaluated include several of the tricyclic antidepressants, trazodone, bupropion, and several of the selective serotonin reuptake inhibitors. Individual antidepressant drugs vary in their pharmacologic activity and side‐effect profiles. Although clinical data are limited, it is important to individualize therapy in order to minimize cardiac adverse effects. Clinicians are encouraged to evaluate patients with cardiac disease for major depressive disorder and to consider antidepressant drug therapy for these patients when appropriate.
Zitterbewegung
 of massless particles

Zitterbewegung of massless particles with an arbitrary spin is analyzed in various representations. Dynamics of the group velocity of a massless particle as a whole and the corresponding radius vector is determined. This radius vector defines any fixed point of the envelope of the moving wave packet characterizing the particle and its group velocity differs from the group velocities of any points of the wavefront. We consider massless scalar and Dirac particles, the photon, and massive and massless particles with an arbitrary spin and describe them in different representations. For particles with an arbitrary spin, the generalized Feshbach-Villars representation and the Foldy-Wouthuysen one are used. Zitterbewegung takes place in any representation except for the Foldy-Wouthuysen one. Formulas describing the particle motion are the same in any representation. In the Foldy-Wouthuysen representation, the operators of the velocity and momentum are proportional and Zitterbewegung does not take place. Since the radius vector (position) and velocity operators are the quantum-mechanical counterparts of the classical position and velocity just in the Foldy-Wouthuysen representation, Zitterbewegung is not observable. The same conclusion has been previously made for massive particles.
P.2.b.021 Is there enough ‘interest in and pleasure in’ the concept of depression – the development of the Leuven Affect and Pleasure Scale (LAPS)

Objective Presence of negative mood (depressed mood) and anhedonia (lack of interest and pleasure) are considered core symptoms of depression, while absence of positive mood is not taken into account. It is therefore remarkable that the depression scales routinely used to assess changes during antidepressant treatment (Hamilton Depression Rating Scale [HDRS], Montgomery–Åsberg Depression Rating Scale [MADRS]) do not really take into account anhedonia. Several scales were developed to assess positive mood and hedonic tone, but they only partially cover the multidimensional concept. Therefore we developed a new 16-item questionnaire, the Leuven Affect and Pleasure Scale (LAPS), to assess negative affect, positive affect, and hedonic tone. Methods This first article on the LAPS questionnaire reports on the correlations between the different items, on the factor analysis, and on the differences found in 3 groups of subjects : healthy college students (N=138), depressed but still functioning college students (N=27), and severely depressed inpatients (N=38). These differences were calculated using univariate general linear models with Bonferroni post-hoc testing, and effect sizes were expressed in η2. Results Negative and positive affect were only moderately correlated, and the 4 independent variables (cognitive functioning, overall functioning, meaningful life, and happiness) had stronger correlations with positive affect than with negative affect. The major difference in negative affect was between healthy college students and depressed college students, positive affect was different between the 3 groups, and the major difference for hedonic tone was between depressed college students and depressed inpatients. Affiliative positive affect and the affiliative hedonic function were well preserved, even in depressed inpatients. Conclusions This preliminary report suggests that the LAPS offers a comprehensive assessment of negative and positive affect, of hedonic tone, and of independent variables (cognitive functioning, overall functioning, meaningful life, and happiness). Clinically relevant differences in subscores were found in 3 groups of subjects with variable levels of depression (healthy subjects, mildly depressed subjects, and severely depressed inpatients).
Effects of Insect Herbivory on Physiological and Biochemical (Oxidative Enzyme) Responses of the Halophyte Atriplex subspicata (Chenopodiaceae)

Abstract Physiological responses of the halophyte, Atriplex subspicata Nutt. Rydb. , to defoliation injury were evaluated through a series of experiments measuring plant gas exchange, fluorometry, and enzyme activity. Leaves exposed to simulated insect herbivory exhibited reductions in photosynthesis, stomatal conductance, and transpiration. Carboxylation efficiency, maximum assimilation, and CO2 compensation were also negatively associated with mechanical leaf injury. Insect injury by a herbivore generalist, Spilosoma virginica, also reduced photosynthesis and carboxylation efficiency within the saturated spectrum of A/Ci response curves. Initially, declines in photosynthesis occurred because of transient stomatal limitations. However, after time, mesophyll limitations impaired photosynthesis and the plant’s ability to compensate for injury. Fluorescence data and light assimilation responses indicated that defoliation did not play a role in limiting light reactions of photosynthesis. Enzyme analyses showed increased peroxidase activity with insect injury, suggesting the need for future characterization of oxidative enzymes, which have been associated with traits of resistance. Overall, we found a salt-tolerant plant to be susceptible to insect herbivory through a reduction in the efficiency of the plant to allocate energy resources. If salt tolerance comes at the cost of susceptibility to biotic interference, natural occurring halophytes or plants with transgenic salt tolerance may be at risk for heightened deleterious response to insect herbivory.
Integrated Phosphoproteomics Analysis of a Signaling Network Governing Nutrient Response and Peroxisome Induction*

Phosphorylation of proteins is a key posttranslational modification in cellular signaling, regulating many aspects of cellular responses. We used a quantitative, integrated, phosphoproteomics approach to characterize the cellular responses of the yeast Saccharomyces cerevisiae to the fatty acid oleic acid, a molecule with broad human health implications and a potent inducer of peroxisomes. A combination of cryolysis and urea solubilization was used to minimize the opportunity for reorientation of the phosphoproteome, and hydrophilic interaction liquid chromatography and IMAC chemistries were used to fractionate and enrich for phosphopeptides. Using these approaches, numerous phosphorylated peptides specific to oleate-induced and glucose-repressed conditions were identified and mapped to known signaling pathways. These include several transcription factors, two of which, Pip2p and Cst6p, must be phosphorylated for the normal transcriptional response of fatty acid-responsive loci encoding peroxisomal proteins. The phosphoproteome data were integrated with results from genome-wide assays studying the effects of signaling molecule deletions and known protein-protein interactions to generate a putative fatty acid-responsive signaling network. In this network, the most highly connected nodes are those with the largest effects on cellular responses to oleic acid. These properties are consistent with a scale-free topology, demonstrating that scale-free properties are conserved in condition-specific networks.
Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

Assessing foot shock sensitivity in rodents can be useful in identifying analgesic or hyperalgesic drugs, and phenotyping inbred or genetically altered mice. Furthermore, as foot shock is an integral part of several rodent behavioral models, sensitivity should also be assessed to accurately interpret behavioral measures from these models. To eliminate variability and increase the efficiency of manually scored shock sensitivity paradigms, we utilized a startle reflex system to automatically quantify responses to varying levels of foot shock. Eight inbred mouse strains were tested for reactivity to foot shock in this system, as well as inherent startle response activity to loud noise bursts. Strain rank order for shock reactivity differed from that for acoustic startle, suggesting that pathways activated in response to each differed. Analgesic doses of morphine and acetaminophen specifically reduced foot shock responses without affecting motor reflexive responses to loud noises in each strain tested. We also tested diazepam and scopolamine, which are often used to disrupt behavior in shock-related paradigms to illustrate the usefulness of this assay. Overall, these results demonstrate that our automated method is a quick and simple way to accurately assess potential foot shock sensitivity differences owing to strain, genotype or drug treatments.
Response of cucumber (Cucumis sativus L.) seedlings to exogenous silicon and salicylic acid under osmotic stress

This study investigates the role of 1.5 mM silicon (Si) and 10 μM salicylic acid (SA) singly or in combination, in inducing cucumber seedlings tolerance to osmotic stress (15% PEG). Osmotic stress reduced shoot fresh and dry mass (SFM, SDM), shoot K+ uptake and leaf area (LA) and increased malondialdehyde (MDA), hydrogen peroxide (H2O2), and ion leakage (IL). Under osmotic stress, Si, SA and Si+SA, increased LA, SFM, SDM, relative water content, total phenolic compounds, anthocyanins, flavonoids, shoot K+ and phenylalanine ammonia lyase (PAL) activity. In all cases the effect of Si+SA was more pronounced. Moreover, Si, SA and Si+SA reduced MDA, H2O2, ion leakage, proline and other aldehydes, under osmotic stress. Meanwhile, under osmotic stress, Si or SA improved seedling performance by enhancing antioxidant enzymes activity, but the better performance of the seedlings under osmotic stress treated with Si+SA was not associated with further enhancement of antioxidant enzymes activity. However, Si+SA treatment significantly increased non-enzymatic antioxidants, total phenolic compounds, anthocyanins, flavonoids, and Si, K+, Ca2+ content in shoot and also PAL activity that might have contributed to higher tolerance of seedling to osmotic stress.
Production and secretion of recombinant thaumatin in tobacco hairy root cultures

Production of recombinant proteins in plant cell or organ cultures and their secretion into the plant cell culture medium simplify the purification procedure and increase protein yield. In this study, the sweet‐tasting protein thaumatin I was expressed and successfully secreted from tobacco hairy root cultures. The presence of an ER signal peptide appears to be crucial for the secretion of thaumatin: without an ER signal peptide, no thaumatin was detectable in the spent medium, whereas inclusion of the ER signal peptide calreticulin fused to the N terminus of thaumatin led to the secretion of thaumatin into the spent medium of hairy root cultures at concentrations of up to 0.21 mg/L. Extracellular thaumatin levels reached a maximum after 30 days (stationary phase) and the subsequent decline was linked to the rapid increase of proteases in the medium. Significant amounts of thaumatin were trapped in the apoplastic space of the root cells. The addition of polyvinylpyrrolidone and sodium chloride into the culture medium led to an increase of extracellular thaumatin amounts up to 1.4 and 2.63 mg/L, respectively. Thaumatin production compares well with yields from other transgenic plants, so that tobacco hairy roots can be considered an alternative production platform of thaumatin.
Human peripheral spatial resolution for achromatic and chromatic stimuli: limits imposed by optical and retinal factors.

1. The aim of this study was to determine whether optical, receptoral or higher‐order neural properties limit spatial resolution (acuity) in human vision, especially in the peripheral regions of the visual field. 2. Both achromatic and chromatic stimuli were used, and measures were taken to ensure that the resolution estimates were not contaminated by the detection of spatial sampling artifacts. Spatial contrast sensitivity functions were measured at retinal locations from 0 to 55 deg along the naso‐temporal meridian for: (i) discriminating the direction of drift of luminance‐modulated (black‐white) sinusoidal stimuli drifting at 8 Hz (achromatic task); and (ii) for detecting isoluminant red‐green sinusoidal stimuli drifting at 0.4 Hz (chromatic task). Achromatic contrast sensitivity functions were also measured along the vertical meridian for eccentricities of 8 and 40 deg. Each achromatic function was extrapolated to a contrast sensitivity of one (100% contrast) to estimate achromatic acuity. Chromatic acuities were obtained by expressing chromatic contrast in terms of cone contrasts and using the same method of extrapolation. We compared the results with recent data on human optical properties and retinal anatomy. 3. Both achromatic and chromatic acuity decline with distance from the fovea, but at a faster rate than that dictated by the known optical and/or receptoral properties of the human eye. We conclude that, for stimuli of either achromatic or chromatic contrast, peripheral spatial resolution is limited by post‐receptoral mechanisms. Also, chromatic acuity declines more steeply than luminance acuity with eccentricity suggesting that there are additional post‐receptoral limitations on colour resolution in the periphery. 4. A clear naso‐temporal asymmetry is seen in the resolution whose dependence is qualitatively, but not quantitatively, similar to the Nyquist limits imposed by the asymmetric density of human retinal ganglion cells. We discuss the possibility that in peripheral vision (beyond the optic nerve head) the spacing of ganglion cells may pose a fundamental limit on the resolution of achromatic stimuli, but not chromatic stimuli.
Computational Analysis of Mammalian Cell Division Gated by a Circadian Clock: Quantized Cell Cycles and Cell Size Control

Cell cycle and circadian rhythms are conserved from cyanobacteria to humans with robust cyclic features. Recently, molecular links between these two cyclic processes have been discovered. Core clock transcription factors, Bmal1 and Clock (Clk), directly regulate Wee1 kinase, which inhibits entry into the mitosis. We investigate the effect of this connection on the timing of mammalian cell cycle processes with computational modeling tools. We connect a minimal model of circadian rhythms, which consists of transcription—translation feedback loops, with a modified mammalian cell cycle model from Novak and Tyson (2004). As we vary the mass doubling time (MDT) of the cell cycle, stochastic simulations reveal quantized cell cycles when the activity of Wee1 is influenced by clock components. The quantized cell cycles disappear in the absence of coupling or when the strength of this link is reduced. More intriguingly, our simulations indicate that the circadian clock triggers critical size control in the mammalian cell cycle. A periodic brake on the cell cycle progress via Wee1 enforces size control when the MDT is quite different from the circadian period. No size control is observed in the absence of coupling. The issue of size control in the mammalian system is debatable, whereas it is well established in yeast. It is possible that the size control is more readily observed in cell lines that contain circadian rhythms, since not all cell types have a circadian clock. This would be analogous to an ultradian clock intertwined with quantized cell cycles (and possibly cell size control) in yeast. We present the first coupled model between the mammalian cell cycle and circadian rhythms that reveals quantized cell cycles and cell size control influenced by the clock.
Prevalence of enterohemorrhagic Escherichia coli O157:H7 in a survey of dairy herds

The prevalence of Escherichia coli O157:H7 in dairy herds is poorly understood, even though young dairy animals have been reported to be a host. From February to May 1993, 662 fecal samples from 50 control herds in 14 states, and from June to August 1993, 303 fecal samples from 14 case herds in 11 states were collected for isolation of E. coli O157:H7. Case herds were those in which E. coli O157:H7 was isolated from preweaned calves in a previous U.S. Department of Agriculture study, whereas control herds from which E. coli O157:H7 had not been isolated previously were randomly selected from the same states as case herds. Among the control herds, E. coli O157:H7 was isolated from 6 of 399 calves (1.5%) that were between 24 h old and the age of weaning and from 13 of 263 calves (4.9%) that were between the ages of weaning and 4 months. Eleven of 50 control herds (22%) were positive. Among the case herds, E. coli O157:H7 was isolated from 5 of 171 calves (2.9%) that were between 24 h old and the age of weaning and from 7 of 132 calves (5.3%) that were between the ages of weaning and 4 months. Seven of 14 case herds (50%) were positive. Sixteen of 31 isolates were obtained by direct plating, with populations ranging from 10(3) to 10(5) CFU/g. Fifteen of 31 isolates were isolated by enrichment only. Nineteen of the isolates produced both verocytotoxin 1 (VT-1) and VT-2, whereas 12 produced VT-2 only.
Clustering of Medical Terms based on Morpho-syntactic Features

The paper presents the first results of clustering terms extracted from hospital discharge documents written in Polish. The aim of the task is to prepare data for an ontology reflecting the domain of documents. To begin, the characteristic of the language of texts, which differs significantly from general Polish, is given. Then, we describe the method of term extraction. In the process of finding related terms, we use lexical and syntactical information. We define term similarity based on: term contexts; coordinated sequences of terms; words that are parts of terms, e.g. their heads and modifiers. Then we performed several experiments with hierarchical clustering of the 300 most frequent terms. Finally, we describe the results and present an evaluation that compares the results with manually obtained groups.
Incidence, management, and prognosis of early ulnar nerve dysfunction in type C fractures of distal humerus.

BACKGROUND Displaced comminuted of the distal humerus in adults are among the most complex fractures to be managed effectively. The ulnar nerve is at high risk of impingement secondary to injury, operation, and postoperative rehabilitation in these fractures. In this study we focus on the incidence, management, and prognosis of early ulnar nerve dysfunction in the course of treating type C fractures of distal humerus. METHODS We examine a patient sample of 117 consecutive AO type C fractures of distal humerus, between June 1998 and October 2005. Twenty-nine patients exhibited preoperative ulnar nerve compression symptoms (incidence 24.8%) and were divided into two groups randomly, which received treatment of anterior subfascial transposition or in situ decompression of the ulnar nerve respectively, in conjunction with internal fixation with medial and lateral plates. RESULTS The subgroup of 88 patients without preoperative ulnar nerve symptoms remained asymptomatic postoperatively (0% incidence of late ulnar nerve dysfunction). According to Bishop rating system, excellent and good results of ulnar nerve function were achieved in 13 of 15 patients (86.7%) in the transposition group, 8 of 14 patients (57.1%) in the in situ decompression group. The results difference is statistically significant (p < 0.05). CONCLUSIONS We conclude that neurolysis and anterior subfascial transposition of vascularized ulnar nerve during open reduction and internal fixation of type C fractures of the distal humerus is beneficial in cases of early ulnat nerve dysfunction.
Explicit search result diversification using score and rank aggregation methods

Search result diversification is one of the key techniques to cope with the ambiguous and underspecified information needs of web users. In the last few years, strategies that are based on the explicit knowledge of query aspects emerged as highly effective ways of diversifying search results. Our contributions in this article are two‐fold. First, we extensively evaluate the performance of a state‐of‐the‐art explicit diversification strategy and pin‐point its potential weaknesses. We propose basic yet novel optimizations to remedy these weaknesses and boost the performance of this algorithm. As a second contribution, inspired by the success of the current diversification strategies that exploit the relevance of the candidate documents to individual query aspects, we cast the diversification problem into the problem of ranking aggregation. To this end, we propose to materialize the re‐rankings of the candidate documents for each query aspect and then merge these rankings by adapting the score(‐based) and rank(‐based) aggregation methods. Our extensive experimental evaluations show that certain ranking aggregation methods are superior to existing explicit diversification strategies in terms of diversification effectiveness. Furthermore, these ranking aggregation methods have lower computational complexity than the state‐of‐the‐art diversification strategies.