Miracle-dz/UniFAR-FTUs huggingface dataset:
LBA39_PRNERATINIB (N) WITH OR WITHOUT TEMSIROLIMUS (TEM) IN PATIENTS (PTS) WITH NON-SMALL CELL LUNG CANCER (NSCLC) CARRYING HER2 SOMATIC MUTATIONS: AN INTERNATIONAL RANDOMIZED PHASE II STUDY

ABSTRACT Aim: Somatic HER2 (ERBB2) mutations occur in approx. 2-4% of pts with NSCLC. In vivo data suggest that combined HER2/mTOR inhibition has synergistic effects in HER2-driven lung tumors [Perera PNAS 2009]. In a phase I study, 5/7 HER2-mutated NSCLC pts showed tumor regression (PR/SD) after treatment with N, an irreversible pan-HER tyrosine kinase inhibitor, and TEM [Gandhi JCO 2014]. The effects of N alone are unknown. This randomized 2-stage phase II study compares N +/- TEM in pts with stage IIIB/IV NSCLC with HER2 somatic mutations. Methods: Pts whose tumors had a documented HER2 mutation were randomized 1:1 to receive oral N 240 mg once daily continuously +/- IV TEM 8 mg/wk (escalated to 15 mg/wk after one 3-wk cycle if tolerated). Addition of TEM was permitted in pts assigned to N alone after progression. High-dose loperamide prophylaxis for diarrhea was mandatory throughout cycle 1. Primary endpoint: overall response rate. Secondary endpoints included: clinical benefit rate, progression-free survival, safety. If > = 2 of 13 pts in each arm have a response at 12 wks in stage 1, a further 26 pts per arm will be enrolled in stage 2. EudraCT ID: 2012-004743-68. Results: 27 pts were enrolled (N, n = 13; N + TEM, n = 14) in stage 1 with approx. 12 wks between randomization of last pt and data cut-off. Baseline characteristics (n = 27): male/female 52%/48%; median age 65 yr; never smokers 63%. Two pts, both in N + TEM arm, had not received prior anticancer medications. Stage 1 results are shown in table. In all pts (n = 27), most common all-grade adverse events (AEs): diarrhea (n = 24), constipation (13), nausea (13), dyspnea (11), asthenia (11), vomiting (11); most common grade 3/4 AEs: dyspnea (4), diarrhea (3; grade 3 only), vomiting (3), nausea (2). Stage 1 Neratinib (N = 13) Neratinib + Temsirolimus (N = 14) Efficacy Overall response rate,* n (%) [90% CI] 0 (0) [0-21] 3** (21) [6-47] Partial response, n 0 3 Stable disease ( > = 12 weeks), n 4 6 Median PFS, months (95% CI) 2.9 (1.4-NE) 4.0 (2.9-9.8) Treatment-emergent diarrhea, n (%) All-grade diarrhea 10 (77) 14 (100) Grade 3 diarrhea 1 (8) 2 (14) * RECIST, version 1.1. ** Two confirmed responses; both pts had not received any prior anticancer medications. Abbreviations: CI, confidence interval; NE, not estimable; PFS, progression-free survival. Conclusions: N + TEM met the efficacy criteria for stage 1 and has been expanded into stage 2. Diarrhea was not a limiting toxicity with aggressive upfront management. Disclosure: B. Besse: Research grants from Puma; B. Yao, A. Lalani, L. McCulloch and R. Bryce: Employed by Puma Biotechnology Inc (study sponsor). All other authors have declared no conflicts of interest.
Opinions of Assistant Doctors in Süleyman Demirel University Medical Faculty About Statistical Knowledge

In scientific investigations; statistical knowledge is essential for collection and analysis of data properly as well as correct interpretation of literature information. In this study that was made in March 1997, opinions of 46 assistant doctors in Suleyman Demirel University Medicine Faculty about statistical knowledge were investigated by a questionnaire. All respondents have agreed on the fact that comprehension of the statistical process in an article was necessary for throughout understanding. Besides, 43 of them (93.5%) admitted that their present statistical knowledge was few or absent at all. All assistant doctors stated that a statistical education program need to be carried out during specialization. According to the majority (66.7%), it had to be not less than ten hours. In addition, most widely defined and interpreted statistical tests among the respondents have turned out to be student's t test with 34.7% definition and 37.0% interpretation ratios, and chi-square with 26.1% definition and 32.6% interpretation ratios.
Food habits and nutrient intake of Kuwaiti males and females

Some current dietary habits, food preparation methods and foods consumed by Kuwaiti citizens are described based on data collected from 500 adults of different education and income levels. The data show that while some traditional food habits are adhered to, others are giving way to western influences. Wheat is the main staple, followed by rice; mutton and lamb are preferred over beef; but chicken and fish are also consumed. Diluted yogurt (roob) is traditionally ingested during lunch, which is the main meal. Fresh fruits and vegetables are readily available, but their consumption is limited by purchasing power. Carbonated beverages, coffee and tea are consumed frequently and sugar utilization is high. Some food preparation practices have different implications on nutrient values of food. In cooking, rice is soaked in warm water for a few hours and then the water is discarded; meat and vegetable mixtures may be boiled for a long time. Such food preparation methods tend to destroy valuable nutrients; but p.
Demo: Tagging IoT Data in a Drone View

Both cameras and IoT devices have their particular capabilities in tracking moving objects. Their correlations are, however, unclear. In this work, we consider using a drone to track ground objects. We demonstrate how to retrieve IoT data from devices, which are attached on human objects, and correctly tag them on the human objects captured by a drone view. This is the first work correlating IoT data and computer vision from a drone camera. Potential applications of this work include aerial surveillance, people tracking, and intelligent human-drone interaction.
Digital Speech Therapy for the Aphasia Patients: Challenges, Opportunities and Solutions

This paper outlines the potential challenges of adopting digital solutions for treating patients with aphasia. Current research has focused on the use of non-immersive Virtual Reality (VR) approach to therapy, and the outcome of their evaluation with people with aphasia has been promising. There is currently no research on the effect of using fully immersive VR technology as a digital therapy solution for people with aphasia. This paper aims to fill that gap by proposing the integration of Immersive VR with an appropriate Artificial Intelligence (AI) powered voice recognition model in creating a digital therapy solution for people with aphasia. The authors hoped that this application will ease the workload of the speech therapist and will enhance the long-term recovery process for people with aphasia.
Brucelose em bovinos com bursite cervical diagnosticada em abatedouro sob inspeção federal

Epidemiological study case-control type carried out in Triângulo abattoir in the city of Uberlândia in the State of Minas Gerais, Brazil, has identified the ocorrence of brucelosis in bovine with supraspinous bursitis, slaughtered from August, 1993 to July, 1994. To diagnose brucelosis "Rapid Agglutination" test was performed on plate with the padronizated antigen count considered positive over 100. The bursas examined were identified by technicians of the Federal Inspection Service based on the presence of ten standardized morphological characteristics. Using the case-control design, 30 animals identified as having supraspinous bursitis were compared with 90 animals randomly selected, without bursitis- but with other characteristics (sex, background, lot, conformation) similar to those affected. All animals were, then, tested for brucelosis. Within the animals with bursitis, 13.33% were found to have brucelosis against 5.56% in the control group (P=0.115). The presence of pus, nodules and viscous fluid was found only among animals who tested negative for brucelosis. The odds ratio found between brucelosis and supraspinous bursitis was 2.61 (P>0.05). As a conclusion its suggested attention of technicians and profesionals employed in slaughter houses aiming to reduce the risk of human infection, as well as of carcasses, equipment and installations contamination.
How Do Workplace Smoking Laws Work? Quasi-Experimental Evidence from Local Laws in Ontario, Canada

There are very large literatures in public health and economics on the effects of workplace smoking bans, with most studies relying on cross-sectional variation. We provide new quasi-experimental evidence on the effects of workplace bans by using the differential timing of adoption of over 100 very strong local smoking by-laws in Ontario, Canada over the period 1997-2004. We employ restricted-use repeated cross section geocoded outcome data to estimate reduced form models that control for demographic characteristics, year fixed effects, and county fixed effects. We first show that the effects of the local laws on actual worksite smoking policy (i.e. the "first stage") were not uniform; specifically, local laws were only effective at increasing ban presence among blue collar workers. Among blue collar workers, adoption of a local by-law significantly reduced the fraction of worksites without any smoking restrictions (i.e. where smoking is allowed anywhere at work) by over half. The differential effect of local policies also improved health outcomes: we find that adoption of a local by-law significantly reduced SHS exposure among blue collar workers by 25-30 percent, and we confirm that workplace smoking laws reduce smoking. We find plausibly smaller and insignificant estimates for white collar and sales/service workers -- the vast majority of whom worked in workplaces with privately initiated smoking bans well before local by-laws were adopted. Overall our findings advance the literature by confirming that workplace smoking bans reduce smoking, documenting the underlying mechanisms through which local smoking by-laws improve health outcomes, and showing that the effects of these laws are strongly heterogeneous with respect to occupation.
A study on the knowledge, attitudes and perceptions of primary health care nurses in the eThekwini Municipality District with regards to the inclusion of homoeopathy in primary health care

The aim of this study was to determine the knowledge, attitudes and perceptions of Primary Health Care nurses in the Ethekwini Municipality District regarding the inclusion of homoeopathy in Primary Health Care. Nurses working in Primary Health Care facilities were approached to conduct this study. The objectives of this study was to make nurses and their patients alike aware of an alternative to conventional medicine, and to the fact that homoeopaths are medically trained practitioners. The survey method used was a self-administered questionnaire to investigate the knowledge, attitudes and perceptions of Primary Health Care nurses towards homoeopathy. The study population was nurses with a minimum of 3 years of general nursing experience, working in Primary Health Care in the Ethekwini Municipality District. The data was collected and analysed statistically using SPSS version 19. A total of 205 questionnaires were distributed and a total of 108 (52.68%) questionnaires were returned with 100 correctly completed and then analysed. The results reflected that 74% of participants felt that homoeopathy should be made available at hospitals and clinics. 69% of participants agreed (strongly agreed or agreed) that homoeopathy should play an active role in the Primary Health Care system in South Africa. The target group’s attitudes were positive as 58% of participants said they would personally use homoeopathy as a source of Primary Health Care. The majority of the participants (71%) felt that homoeopathy should be available as a treatment for most conditions. The study demonstrated an otherwise positive trend of support of those Primary Health Care nurses surveyed toward the possible inclusion of homoeopathy in Primary Health Care. Further research into the nature of such integration and the potential contribution of homoeopathy and homoeopathic practitioners is warranted. This study has established a perceived requirement for Primary Health Care nurses to be exposed to education programs which may introduce the concepts of CAM, homoeopathy and its regulations in South Africa. These nurses may then reliably guide their patients that have a historical use or future need of such services. Generalisation of results and conclusions regarding the perceptions of Primary Health Care nurses regarding homoeopathy can be tentative.
An MPD Player with Expert Knowledge-basedSingle User Music Recommendation

This work demonstrates a music player based on Music Player Daemon (MPD), a protocol popular for audiophiles, with personalized music recommendation. As a standalone player, we focus on the scenario of single user recommendation. Different from collaborative filtering based recommendation, which relies on usage patterns from a large number of users, we propose a novel approach that does not require other users’ information. We formulate the recommendation as a task of knowledge base completion and exploit the expert knowledge from a music knowledge base. The effectiveness of our approach is evaluated, and the player is released as an open-source software for music lovers.
Distributed Partial Clustering

Recent years have witnessed an increasing popularity of algorithm design for distributed data, largely due to the fact that massive datasets are often collected and stored in different locations. In the distributed setting, communication typically dominates the query processing time. Thus, it becomes crucial to design communication-efficient algorithms for queries on distributed data. Simultaneously, it has been widely recognized that partial optimizations, where we are allowed to disregard a small part of the data, provide us significantly better solutions. The motivation for disregarded points often arises from noise and other phenomena that are pervasive in large data scenarios. In this article, we focus on partial clustering problems, k-center, k-median, and k-means objectives in the distributed model, and provide algorithms with communication sublinear of the input size. As a consequence, we develop the first algorithms for the partial k-median and means objectives that run in subquadratic running time. We also initiate the study of distributed algorithms for clustering uncertain data, where each data point can possibly fall into multiple locations under certain probability distribution.
Incidence of Canine Appendicular Musculoskeletal Disorders in 16 Veterinary Teaching Hospitals from 1980 through 1989

Summary The goal of this study was to determine the incidence of musculoskeletal disorders in a large canine population. Patient information was obtained from clinical cases contributed to the Veterinary Medical Data Base (VMDB) by 16 veterinary teaching hospitals during the ten year period of 1980 through 1989. The relative contribution of bone diseases, joint diseases, and muscle-tendon-unit diseases was determined, and the incidence of each musculoskeletal disease reported. Nearly 24% of all patients in the source population had been affected by a disorder of the musculoskeletal system, and over 70% of those diagnoses involved appendicular structures. Diseases of joints, ligaments, and related structures contributed more cases (47%) to this study than diseases of bones (39%) or muscle-tendon-units (14%). Fractures made up the largest disease category, with pelvic fractures most common, followed by femoral fractures, and fractures of the radius and/or ulna. Joint instability and degenerative joint dis- ease were also common diagnosis categories, affecting primarily the hip and stifle joints. Common specific dis-ease entities included hip dysplasia, cruciate ligament rupture, traumatic hip luxation and patellar luxation. In this study we provided a comprehensive analysis of the canine musculoskeletal system. The relative importance of joint disorders compared to those of bones and muscle-tendon-units was illustrated. The incidence of most of the disorders described in this report had not been well documented previously. Patient information was obtained from the clinical cases of 16 veterinary teaching hospitals during a 10-year period. The number of dogs with musculoskeletal disorders was determined. The absolute and relative contribution of bone diseases, joint diseases, and muscle-tendon-unit diseases is reported as well as the incidence of the specific disease entities affecting the canine appendicular musculoskeletal system.
Development of a Novel Synthetic Drug for Osteoporosis and Fracture Healing

Abstract : This is a progress report (year 2) for the development of a novel therapeutic drug (salubrinal) for skeletal diseases, focusing on potential treatment of osteoporosis and bone fracture. The study in the second year using animal models and in vitro cell cultures strongly supported salubrinal s action on prevention of bone loss. In animal experiments, we employed three procedures to induce bone loss. They were ovariectomy, hindlimb suspension, and administration of glucocorticoid (prednisolone). In all three models, salubrinal was able to suppress reduction of bone mineral density. In those experiments, salubrinal was administered via subcutaneous injection as well as oral gavage. In in vitro experiments, salubrinal reduced the development of bone-resorbing osteoclasts and promoted the development of boneforming osteoblasts. A provisional patent was submitted for salubrinal s administration for treatment of bone diseases, and the peer-reviewed articles as well as conference abstract were published. In the third year, we will start evaluating the effects of salubrinal on the healing of bone fracture as well as the regulatory mechanism of salubrinal s action.
Whether cultural identity and trust have an impact on the willingness to buy online streaming platforms?

This study is mainly aimed at users from different countries in the online streaming website to watch the film situation. An online questionnaire was designed for data collection. Sampling was performed using a non-probabilistic convenience sampling method.To survey the online media-streaming preferences of users in different countries. The study results verified the relevance of trust and cultural identity in online streaming platforms. According to the findings, online streaming service providers should endeavor to not only enhance consumers' perceived playfulness when they stream movies and TV shows and their familiarity with the platform interface but also garner consumers' trust in the platform. Moreover, these providers are recommended to analyze the market and launch new products by considering cultural identity to provide consumers with a wider variety for selection, thus increasing the consumer base, purchase intention, and economy of scale.
Serum Uric Acid Levels Improve Prediction of Incident Type 2 Diabetes in Individuals With Impaired Fasting Glucose: The Rancho Bernardo Study

Oda and Kawai (1) point out that uric acid (UA) levels may predict incident type 2 diabetes differently in men versus women. In our article (2), UA predicted type 2 diabetes independent of age, BMI, diuretic use, estimated glomerular filtration rate, and sex. Among 566 …
Spectrum-based fault localization for context-free grammars

We describe and evaluate the first spectrum-based fault localization method aimed at finding faulty rules in a context-free grammar. It takes as input a test suite and a modified parser for the grammar that can collect grammar spectra, i.e., the sets of rules used in attempts to parse the individual test cases, and returns as output a ranked list of suspicious rules. We show how grammar spectra can be collected for both LL and LR parsers, and how the ANTLR and CUP parser generators can be modified and used to automate the collection of the grammar spectra. We evaluate our method over grammars with seeded faults as well as real world grammars and student grammars submitted in compiler engineering courses that contain real faults. The results show that our method ranks the seeded faults within the top five rules in more than half of the cases and can pinpoint them in 10%–40% of the cases. On average, it ranks the faults at around 25% of all rules, and better than 15% for a very large test suite. It also allowed us to identify deviations and faults in the real world and student grammars.
secGAN: A Cycle-Consistent GAN for Securely-Recoverable Video Transformation

Video streaming is one of the critical functionalities on edge devices, like IP cameras, because it enables many applications in mobile scenarios, such as live street viewing or surveillance video analytics. In the streaming pipeline, video transformations is commonly used to remove or change visual details for different purposes like privacy preservation. So far, many advanced full-frame transformations are empowered by deep learning technologies, especially the family of cycle-consistent Generative Adversarial Networks (cycGANs). However, such cycGANs cannot be directly applied to edge devices due to security issues raised in practice. If an active adversary is present, the video frame transformed by cycGANs may be recovered to its original form without any authorization. Besides, there is no mechanism to verify whether this frame is indeed transformed in a legitimate way. Therefore, we design a secure version of cycGANs by introducing a ''secret key'' concept to the model design. This new cycGAN, the secGAN, can protect its video transformation outputs and is also suitable to run on edge devices with considerations of running efficiency.
LEAGUE OF LEGENDS

O presente estudo traz a tona do jogo eletronico League of Legends tambem chamado de LOL. O estudo tem como objetivo geral, analisar se a pratica constante do jogo League of Legends pode influenciar diretamente no estilo de vida saudavel e nas capacidades fisicas dos praticantes. Bem como os objetivos especificos sao caracterizar os participantes da pesquisa, caracterizar a amostra com relacao ao estilo de vida, verificar como esta a agilidade dos jogadores de League of Legends e verificar os niveis de flexibilidade dos jogadores de League of Legends. A revisao de literatura contempla topicos como o sedentarismo, aptidao fisica abordando tambem a agilidade e flexibilidade, jogos eletronicos e ainda o outro sub topico League of Legends. A pesquisa caracteriza-se como pesquisa de campo de carater quantitativo. A populacao do presente estudo sao os jogadores do jogo eletronico League of Legends. A amostra foi nao probabilistica intencional, contou com 6 jogadores do sexo masculino 5 residentes no municipio de Antonio Olinto PR e 1 residente no municipio de Lapa PR. O instrumento utilizado para a coleta de dados foi um questionario e teste de agilidade o Shuttle Run e teste de flexibilidade o Banco de Wells. Apos aplicacao dos testes pode-se verificar que a pratica constante do jogo League of Legends pode influenciar nas capacidades fisicas dos jogadores, sendo que o resultado do teste agilidade classificaram-se entre ruim e abaixo da media e o resultado do teste de flexibilidade ficou entre fraco e baixo da media. Em relacao ao questionario de Nahas os resultados de atividade fisica, comportamento preventivo e relacionamento social apresentaram resultados medianos, ja a componente nutricao apresentou resultado negativo e controle de estresse apresentou resultado positivo. Pode-se concluir que o jogo League of Legends pode interferir no estilo de vida saudavel e no desenvolvimento das capacidades dos praticantes, agravado pelo alto tempo de pratica.
Some Thoughts on the Prevalence and Etiology of Depressive Conditions in the Elderly

Abstract This article reevaluates the issue of the prevalence of depressive conditions (clinical depressions and depressive symptoms) in the elderly with the help of recent epidemiological data. It then underlines several key aspects of the etiology of depressive conditions of older adults. The perspective is a psychosocial analysis, which considers the etiological contributions of three types of factors: the socio-demographic status of the person, life events, and the resources of the person. The article concludes by delineating the implications for research in this area.