Miracle-dz/UniFAR-FTUs huggingface dataset:
EZH2 and Sonic Hedgehog Inhibition Reduce Proliferation, Migration, In Vitro Tumorigenesis, and CD133 Expression in Desmoplastic Medulloblastoma Cells

Medulloblastoma is the malignant brain tumor that most affects children and young people. Its treatment is very aggressive and can leave important neurocognitive sequelae in patients. Medulloblastoma can be classified histologically and molecularly in different subtypes. Our work focuses on the specific subtype in which the sonic hedgehog pathway is altered. DAOY cells, which correspond to desmoplastic Shh medulloblastoma, were independently treated with two pharmacological inhibitors: cyclopamine and DZNep. Cyclopamine directly inhibits Smo, thus inhibiting the sonic hedgehog pathway; while DZNep acts at the epigenetic level by inhibiting EZH2 function, a histone-lysine N-methyltransferase. The two inhibitions were compared cellularly and molecularly, demonstrating that both drugs reduced cell viability, colony formation, cell migration and the expression of cancer stem cells related genes, like CD133. In addition, the expression of different genes of the sonic hedgehog, EZH2, and other genes regulated by EZH2 and GLI1 were evaluated. The initial hypothesis, according to which the expression of EZH2 would regulate the sonic hedgehog pathway was not demonstrated. Quite the opposite, we observed that the sonic hedgehog pathway could positively regulate EZH2 expression. Our results, however, should be subjected to further experiments in order to elucidate the relationship between the epigenetic regulation exerted by EZH2 and the regulation of the sonic hedgehog pathway in medulloblastoma.
Growth and mortality in successive cohorts of fish larvae within an estuarine nursery

The young of many coastal fishes appear on estuarine nursery grounds in a progression of successive cohorts, few of which encounter identical environmental conditions. Using in situ manipulations, I explored the effects of natural environmental variability and use of a nursery habitat by prior cohorts on growth and mortality rates in successive larval cohorts of the mummichog Fundulus heteroclitus, a cyprinodontid fish common in salt marshes along the east coast of North America. Variation in mean daily specific rates of growth (G = 0.027 to 0.143) and mortality (Z = 0.007 to 0.1 18) within and among cohorts was associated with the tidal cycle. Growth rate was positively associated and mortality rate negatively associated with the duration of tidal flooding experienced by groups of fish larvae. Tidal flooding may have affected growth and survival by controlling the renewal rate of prey resources (primarily harpacticoid copepods) in intertidal aquatic microhabitats where the fish larvae are normally found. Overall high survival (up to 90 % after 2 wk) of larvae in experimental cohorts was attributed to the exclusion of predators from field enclosures. Successive cohorts of larvae were not nutritionally independent and use of the nursery habitat by a prior cohort usually had a negative effect on survival of larvae in the next cohort. These findings challenge the general tenet that fish larvae are not foodlimited in nurseries and suggest how variation in the phys~cal environment can restrict food availability even in a highly productive estuarine habitat. The spawnlng pattern of F heteroclitusseems to combine features from along a continuum of reproductive strategies exhibited by other marine fishes and may contribute to maintaining a large and stable population in a fluctuating estuarine environment.
Incidence and clinical picture of upper respiratory infection in children receiving zinc supplement

The National Household Health Survey (1995) reported that the prevalence of upper respiratory infection (URI) in Indonesia was found 25.3% for all ages and 47.1% for the under five children. Reports of studies on the effect of zinc in the reduction of respiratory infection stated inconsistentresults. The objective of this community base study is to evaluate the effect of zinc as the attempt to reduce the incidence of URI. We have studied the effect of daily supplementation of 10 mg elemental zinc in a double blind, randomized, controlled trial consisting of 37 children (zinc group) and 36 children (control group) of 6 months - 5 years old. The distribution of preparation and monitoring of morbidity were performed regularly once a week along 2-month study period. During the 2-month study (February-April 2001) we found 24 URI cases in the zinc group and 24 cases in the control group. Time series analysis concerning the incidence and severity of the zinc group showed a negative slope (Yt: a – bx), while the placebo group showed a positive slope (Yt: a + bx). The evidence and severity of URI in zinc groups within the 1st and 2nd months showedsignificant different, while it was not in the control group. The study obviously showed the benefit of zinc supplementation in the reduction of URI as showed by negative slope in the time series analysis, and significant decreased of the incidence and the severity of URI in zinc group. There was no side effect of zinc supplemented noted. We suggest, therefore regular zinc supplementation to the diet of the children in the low economic level community are needed.
Seismic Vulnerability Maps of Ratu Agung District, Bengkulu City, Indonesia

During the 8.6 Mw Bengkulu-Mentawai Earthquake Ratu Agung District was identified as an impacted area. This paper aims to deliver the seismic vulnerability based on geophysical observation. This study was initiated by performing the ambient noise measurement to obtain the geophysical characteristic, such as amplification and predominant frequency. Furthermore, the vulnerability index analysis was performed from the geophysical information collected from the investigation. To observe the tendency of ground damage during the earthquake, ground damages analysis is also performed. All results are depicted into the microzonation maps. The results showed that the amplification and predominant frequency on site are generally ranging from 3 to 5 and 5 to 8 Hz, respectively. The seismic vulnerability index in study area is up to 10-3. The results showed that during the Bengkulu-Mentawai Earthquake, the investigated sites could be possible to undergo crack settlement which can trigger massive sand boiling in the study area.
Study of the Addition of a Thermoplastic Vulcanizate to a HDPE Composite Highly Filled with Magnesium Hydroxide and Its Effect on the Tensile and Flame Retardant Properties

A work was carried out in order to obtain a TPV based on HDPE and EPDM, studying the effect of three different peroxides. The effect of one mono- and two bifunctional peroxides was studied. In general, at equal wt% of peroxide, the bifunctional peroxides produced greater gel content, higher tensile stress, and higher elongation at break. Thereafter, the work was focused on studying the effect of this TPV, as well as a commercial TPO, on the tensile and flame retardant properties of composites based on blends of HDPE and a thermoplastic elastomer (either TPV or TPO), plus 130 phr of magnesium hydroxide (MH). The composites without the rubbery phase, but with 130 phr of MH, were highly brittle and fragile. The composites with the rubbery phase, on the other hand, (either TPO or TPV), were tougher and presented relatively much higher tensile properties. With regard to flame retardancy, the formulations containing the TPV showed better flame retardancy and passed as V-1 in the UL-94V. With respect to the cone calorimeter, those with TPO or TPV all generated a total of 80 MJ of heat energy. The compositions with TPV, however, generated this amount of heat over a larger period of time, i.e., showing less heat generated per second. In addition, the compositions with TPV presented a markedly lower pHRR, by an average of 15%. Thermogravimetric analysis (TGA) showed that the MH in the samples with a 40 wt% rubbery phase starts decomposing at 315°C. However, as the temperature increases, the MH in the TPV composite apparently decomposes at a slower rate than that in the TPO composite.
Title The role of online buzz for leader versus challenger brands : the case of the MP 3 player market Permalink

Online buzz reflects the perceived quality of products in a positive, negative, or neutral way. We have limited understanding of how customers’ quality perceptions, often referred to as e-sentiment, affect the movement of prices. In this paper, we examine the effect of e-sentiment on the daily price fluctuations of MP3 players by using daily buzz information collected from diverse online documents. Econometric panel data modeling reveals that e-sentiment is a leading indicator of price fluctuations. Furthermore, we find the effect is moderated by the brand’s market position: the leading (challenger) brand’s price responds more strongly to negative (positive) online buzz. In other words, negative buzz has a greater adverse effect on leading brands, whereas positive buzz has a greater beneficial effect on challenger brands. These findings establish the relevance of e-sentiment information to online price movements and suggest that managers should frequently monitor the online buzz surrounding their products, especially as it relates to their relative perceived quality.
The Study of the Relationship Between the Quality of Work Life and the Organizational Commitment of the Employees of the Municipality of Zarandieh, Iran

The research has not sponsor. This article is the result of the M.Sc. thesis of Hakim Nasser Khosrow Saveh Higher Education Institution. The researchers expressed their gratitude and appreciation to the participants and principal of the municipality of Zarandieh, Iran for their cooperation to conducting this research. Abstract The present study aimed to determine the relationship between the quality of work life and organizational commitment of the employees of the municipality of Zarandieh, Iran. This research was a survey. Simple random sampling method was used to select 112 employees. A questionnaire including personal information, quality of work life, and organizational commitment was used to collect data. Data were analyzed by SPSS software version 20. The results showed that there was a significant correlation between organization commitment with health and safety (r=0.24), economic and family (r=0.28), social (r=0.44), self-esteem (r=0.40), cognitive and knowledge (r= 0.50), and aesthetic needs (r= 0.26). In general, there are positive and significant relationship between all components of quality of work life with organizational commitment (p<0.05). Keywords: Quality of work life, Organizational commitment, Municipality, Employee DOI : 10.7176/JAAS/58-03 Publication date :September 30 th 2019
AutoTMTDyn: A Matlab Software Package to Drive TMT Lagrange Dynamics of Series Rigid- and Continuum-link Mechanisms

Having a reliable accurate and at the same time simple dynamic model is important in analysis, design, path planning and control of robotic systems. Such models should be fast, convenient and simple to use to be accepted by the ever growing robotics research community. Among all the challenges, controlling complex systems with compound rigid and continuum body mechanisms with switching dynamical behavior, due to interaction with their environment in different applications, has attracted much research recently. To address these concerns, we have upgraded the AutoTMTDyn Matlab software package, a recently introduced tool for deriving Lagrange Equations of Motion (EOM) in a vector formalism, with the ability to handle series continuum-link mechanisms, e.g. continuum manipulators, and introducing an easy to use high level language (HLL) as a new text-based user interface. The variable curvature kinematics and TMT Lagrange dynamics of a continuum beam is derived in differential and discrete forms. The HLL elements are described and showcased in modeling and analysis of three bioinspired dynamical systems; lumped-system model of a spider web, continuum model for a rat whisker, and modeling a continuum pneumatic module. The challenges with using the package for systems with large modeling states, and the necessary modules to further automate the analysis of the dynamic systems are briefly discussed. KeywordsLagrange Dynamics, Continuum Mechanism, High Level Language, Software.
Objective Assessment of Extratropical Weather Systems in Simulated Climates

An automated weather system identification and tracking scheme is used to appraise the skill of the CSIRO9 GCM in replicating contemporary extratropical cyclone and anticyclone behavior, and to assess possible changes as a result of doubled CO2. Cyclones are identified as centers of cyclonic vorticity rather than pressure minima, which can vanish if the background pressure gradient increases. Comparison with an observational dataset from ECMWF revealed that the GCM control simulation realistically reproduced the present-day storm track locations, but with slightly fewer and generally weaker systems overall. These errors are consistent with the coarser resolution of the GCM and its underestimation of the strength and baroclinicity of the polar vortex in both hemispheres. Comparison between 1 and 2 3 CO2 GCM simulations revealed increases in both 500-hPa geopotential height and 1000‐500-hPa thickness for doubled CO2. As in other studies, these changes are largest near the poles, resulting in weaker westerlies and reduced tropospheric baroclinicity. Decreases of 10%‐15% in both cyclone and anticyclone activity consistent with these circulation changes are found. However, there is some evidence of increased winter cyclone activity near the downstream end of the principal storm tracks. There is also a general reduction in the number and strength of intense storms, despite generally lower central pressures, which arise from global-scale decreases in sea level pressure in the doubled CO 2 atmosphere rather than from greater storm vigor. This underscores the need for GCM projections of midlatitude ‘‘storminess’’ to employ more realistic measures of storm activity and intensity.
Light Scattering From a Cluster Consists of Layered Axisymmetric Objects

Random-orientation scattering properties of a plane wave scattered by an arbitrary, symmetric cluster consists of coated spherical and coated spheroidal particles are presented. The calculation is based on a method that calculate the cluster T-matrix, and from which the orientation-averaged scattering matrix and total cross sections can be analytically obtained. Numerical results for the random-orientation scattering matrix are presented. The cluster consists of particles ensemble the form of a densely packed cluster and linear chains.
CHEMICAL MANAGEMENT OF BROADLEAF BUTTONWEED AND BRAZILIAN PUSLEY IN DIFFERENT APPLICATION

Increased use of glyphosate in transgenic soybean areas has selected resistant and tolerant weed species. The aim of this study was to evaluate chemical management strategies for controlling Borreria latifolia and Richardia brasiliensis at pre-emergence (Pre), early post-emergence (Poste) and late post-emergence (Postl). Six experiments were carried out in a completely randomized design with four replicates per treatment in the Pre experiments and three in the Poste and Postl experiments, for each of the species. In the Pre experiments, tests were performed with herbicides imazethapyr, sulfentrazone, chlorimuron, diclosulam, S-metolachlor and saflufenacil. In the Poste experiments, seedlings were sprayed with herbicides bentazon, fomesafen, lactofen, flumioxazin and glyphosate. In Postl experiments, adult plants received glyphosate application associated with herbicides 2,4-D, carfentrazone, imazethapyr, flumiclorac, flumioxazin, sulfentrazone, chlorimuron, saflufenacil and glufosinate, plus three sequential applications with glyphosate only and paraquat/diuron. In the experiments, there was a control treatment without application of herbicides. In the Pre experiments, the plants established at 14 and 28 days after application (DAA) were evaluated. In the Poste and Postl experiments, shoot dry matter evaluation and visual control were performed at 14 and 28 DAA. The herbicides sulfentrazone, S-metolachlor and saflufenacil suppressed the emergence of both B. latifolia as R. brasiliensis; chlorimuron-ethyl and diclosulam were effective only on R. brasiliensis. In Poste, fomesafen, lactofen and flumioxazin reached levels of control over 90% of plants of both species. In Postl, glyphosate associated with carfentrazone, flumiclorac, flumioxazin, chlorimuron-ethyl, saflufenacil, glufosinate, and sequential applications of glyphosate/glyphosate, glyphosate/paraquat+diuron, glyphosate+2,4-D/paraquat+diuron reached levels control higher than 95%.
THE RELATIONSHIP BETWEEN PSYCHOLOGICAL EMPOWERMENT AND PSYCHOLOGICAL WELL BEING : THE ROLE OF SELF-EFFICACY PERCEPTION AND SOCIAL SUPPORT

The objective of this study is to examine the relationship between psychological empowerment and psychological well being. Additionally, it is aimed to find evidences about the mediating role of individuals’ self-efficacy perception and the moderating role of perceived supervisor social support on the relationship between psychological empowerment and psychological well-being at work. The effect of psychological empowerment on work-related psychological well-being and the roles of self-efficacy and social support were examined through a structured research survey which has been performed among teaching staff working in public primary schools in Istanbul-Kadıköy. The hypotheses were generated and empirically tested by the data obtained from the participants. The results have demonstrated that all four dimensions of the psychological empowerment had significantly positive relationships with psychological wellbeing states of the individuals. Moreover, the statistical findings have revealed that self-efficacy perception had a partial mediating role and perceived social support had a significant moderating role on the relationship between psychological empowerment and well-being. Furthermore, the findings of this study have provided insights to various public and private organizations from different sectors which aim to enhance psychological well-being of the individuals and try to improve their work-related positive affections at the workplace.
GAMMA-RAY TIMING OF REDBACK PSR J2339–0533: HINTS FOR GRAVITATIONAL QUADRUPOLE MOMENT CHANGES

We present the results of precision gamma-ray timing measurements of the binary millisecond pulsar PSR J2339–0533, an irradiating system of the “redback” type, using data from the Fermi Large Area Telescope. We describe an optimized analysis method to determine a long-term phase-coherent timing solution spanning more than six years, including a measured eccentricity of the binary orbit and constraints on the proper motion of the system. A major result of this timing analysis is the discovery of an extreme variation of the nominal 4.6 hr orbital period P orb ? > over time, showing alternating epochs of decrease and increase. We inferred a cyclic modulation of P orb ? > with an approximate cycle duration of 4.2 yr and a modulation amplitude of Δ P orb / P orb = 2.3 × 10 − 7 ? > . Considering different possible physical causes, the observed orbital-period modulation most likely results from a variable gravitational quadrupole moment of the companion star due to cyclic magnetic activity in its convective zone.
Every Cloud Has a Silver Lining: A History of Barriers to Intellectual Capital Measurement

The purpose of this paper is to contribute to the Intellectual Capital Accounting (ICA) literature by investigating the barriers to IC measurement and how they can (re)shape IC measurement projects. The paper presents an interventionist case study of a company which has been measuring its IC for several years. It focuses on some emblematic situations in which barriers arose during the design and implementation of IC indicators followed by a (re)moulding of the IC measurement project within the organization. The case analysis revealed two barriers: the heavy workload that the design and calculation process of IC indicators entails and the perceived limited reliability of those indicators. These barriers did not lead to a complete failure of the project, but acted as a “filter”, resulting in the discontinued use of those indicators that were not perceived as useful or reliable and in the adoption of those that the managers actually considered useful. While this hindered a complete implementation of the ICMS, it promoted a selection of IC indicators and a legitimation of those that subsequently became part of the management control system. While previous studies explore how barriers can hamper the design as well as the implementation of an ICMS, this paper sheds light on what happens to IC measurement projects when the magnitude of barriers is not so significant as to lead to the complete failure of the project. This offers a new and different view of the barriers related to the adoption of ICMSs. Rather than considering them as factors which can interrupt IC measurement, they could be seen as factors which can challenge the implementation of the ICMS, strengthening those IC indicators that are perceived as reliable and useful and eliminating or disregarding those that did not meet expectations.
THE INFLUENCE OF EFFECTIVE BOARD OF COMMISSIONERS AND AUDIT COMMITTEE ON THE INFORMATIVENESS OF EARNINGS: EVIDENCE FROM INDONESIAN LISTED FIRMS

The existence of governance structure such as board of commissioners and audit committee implies a better monitoring function on the financial reporting process that will result in higher informativeness of earnings. Nevertheless, the quality of the monitoring function depends on how effective the board and the audit committee perform their duties. This study examines how the effectiveness of the board of commissioners and audit committee in a twotier board structure influences the informativeness of earnings which is measured by Earnings Response Coefficient (ERC). The level of effectiveness is defined as the extent to which the board of commissioners and the audit committee perform their duties according to their responsibilities, which is associated with the board and audit committee characteristics. This study develops a score for board and audit committee effectiveness by using a checklist which captures how the independence, activity, size, and competence characteristics are reflected in the board of commissioners and audit committe. Previous studies find that these characteristics are required to enable the board and audit commitee perform better governance. Each question in the checklist will be scored 1 (Poor), 2 (Fair), or 3 (Good) based on the information disclosed in company annual reports. Hypothesis testing is carried out by using a multiple regression model of 357 observations (firm-year) with the sample taken from companies listed on the Indonesian Stock Exchange during the period 2006-2007. Results of this study provide robust evidence that a more effective board of commissioners improves the informativeness of earnings. However, the results for the influence of the audit committee effectiveness are still mixed. The findings indicate that the effectiveness of the audit committee does not affect the informativeness of earnings, but further analysis indicates that audit committee effectiveness has a positive effect on ERC when the board of commissioners is not effective in performing its role. Based on these findings, this study indicates that audit committee is an integral part of board of commissioners so that the role of board of commissioners still have significant role in the monitoring function because the audit committee actually act on behalf of and report to the board of commissioners. Therefore, the role of audit committee will be more revealed when the board itself is actually less effective. This is consistent with the objective of the audit committee formation which is to provide a complementary function for the board of commissioners monitoring role.