Miracle-dz/UniFAR-FTUs huggingface dataset:
Structural aberrations in T-even bacteriophage. VII. In vitro analysis of the canavanine-mediated inhibition of proteolytic cleavage

Canavanine arrests a critical function in head morphogenesis and the potential for forming giant T-even phage particles termed lollipops is induced. Formation of the particles requires the addition of arginine and the restoration of normal functions. We now report on an investigation into the effects of canavanine on both the T4-induced proteolytic activity and on the substrate proteins. Using an in vitro cleavage assay we have shown that the gene 21-dependent proteolytic activity from canavanine-treated extracts is markedly inhibited, whereas the substrate proteins retain a high susceptibility for cleavage. The proteolytic activity in extracts treated with canavanine followed by arginine is readily detectable, and proteins previously synthesized in the presence of canavanine can be cleaved. Protein synthesis is apparently required for the appearance of the proteolytic activity after the canavanine-arginine treatment. Mixing experiments suggest the requirement for a component of the gene 21-dependent proteolytic activity that is not coded for by gene 21.
Arrhythmogenic right ventricular dysplasia/cardiomyopathy: need for an international registry. Study Group on Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy of the Working Groups on Myocardial and Pericardial Disease and Arrhythmias of the European Society of Cardiology and of the Scienti

Arrhythmogenic right ventricular (RV) dysplasia/cardiomyopathy (ARVD/C) is a heart muscle disease characterized by peculiar RV involvement and electrical instability that precipitates ventricular arrhythmias and sudden death. The purpose of the present consensus report of the Study Group on ARVD/C of the Working Groups on Myocardial and Pericardial Disease and Arrhythmias of the European Society of Cardiology and of the Scientific Council on Cardiomyopathies of the World Heart Federation is to review the considerable progress in our understanding of the etiopathogenesis, morbid anatomy, and clinical presentation of ARVD/C since it first was described in 1977. The present article focuses on important but still unanswered issues, mostly regarding risk stratification, clinical outcome, and management of affected patients. Because ARVD/C is relatively uncommon and any one center may have experience with only a few patients, an international registry is being established to accumulate information and enhance the numbers of patients that can be analyzed and thus answer pending questions. The registry also will facilitate pathological, molecular, and genetics research on the causes and pathogenesis of the ARVD/C. Furthermore, availability of an international database will enhance awareness of this largely unrecognized condition among the medical community. Physicians are encouraged to enroll patients in the International Registry of ARVD/C.
Interventions for Disability Management

Background: With an increasing prevalence of low back pain, management can include modified work, work-conditioning, or work-hardening programs. Modified work programs, or employer's worksite interventions or clinic-based programs under medical supervision, provide a gradual increase of workload. Work-conditioning programs, or unimodal physical conditioning and function activities, promote return to work. Work-hardening programs, or graded work simulations and psychological interventions, are used as part of an interdisciplinary program addressing physical and functional needs. Objective: The objective of the review was to determine how effective modified work programs, work hardening, and work conditioning are in the management of chronic pain disability. Methodology: The literature search identified two systematic literature reviews to provide the evidence about these interventions for disability management. Results: Studies of work conditioning showed methodological variability, heterogeneous subjects, variable definitions of modified work, and limited outcome measures. Using return-to-work outcomes, 8 of the 11 studies of adequate methodological quality reported positive effects of modified work programs, mostly light duty. For work conditioning and work hardening, studies showed methodological variability combined with heterogeneous subjects, including varying times out of work and varying work ethics from different countries. Most study results were uncertain, though results of three of the four medium-quality studies were positive. Conclusions: Modified work programs may improve return-to-work rates of workers with work-related injuries for 6 months or longer (level 2). There is inadequate evidence (level 4a) to determine what particular aspects of modified work programs are helpful. Work conditioning and work hardening may or may not improve the return to work of more chronically disabled workers (level 4b).
Comparative Efficacy of Two Different β‐Blockers on 24‐Hour Blood Pressure Control

Atenolol and metoprolol succinate, dosed once daily, have different pharmacokinetic profiles. This study tests the hypothesis that differences that are especially noted in the early morning period, when cardiovascular risk is highest, in 24‐hour blood pressure (BP) control exist between these 2 β‐blockers. This was a small, randomized open‐label study with blinded end point evaluation in 36 hypertensive patients. All participants received hydrochlorothiazide 12.5 mg for 2 weeks before randomization to either 50 mg atenolol or metoprolol succinate given every morning; both treatments were force‐titrated to 100 mg/d at 4 weeks. The primary end point was the change in early morning ambulatory systolic BP. Early morning (12 am–6 am) systolic BP differences were 3±14 mm Hg with atenolol vs −7±8 mm Hg with metoprolol succinate (P=.03). The overall 24‐hour changes in systolic BP were 1±15 mm Hg with atenolol vs −9±11 mm Hg with metoprolol (P=.03). In conclusion, metoprolol succinate was more effective in sustaining 24‐hour and early morning BP reductions compared with atenolol in a small group of hypertensive patients also treated with once‐daily low‐dose hydrochlorothiazide. It is possible that differences in outcome between atenolol‐based and other therapies may be the result of inadequate dosing of atenolol, a medication that may not be effective for the entire 24‐hour period.
Fecundity in Thai and European regions: results based on waiting time to pregnancy.

Very little is known about the frequency of subfecundity in different cultures, ethnic groups and regions. To fill this gap, the European Study Group on Infertility and Subfecundity established data on the prevalence of infertility and subfecundity in five European regions. In this study, a comparison of fecundity was made between 4035 Caucasian women from five European countries and 1496 Asian women from southern Thailand. Fecundity was measured using 'time to pregnancy', i.e. the time women took to conceive after stopping contraceptive methods. The Thai primigravid women had a shorter time to pregnancy than European women, whereas time to pregnancy was found to be longer among Thai multigravidae, although this was not statistically significant. This study has illustrated that cross-culture comparison of subfecundity is difficult despite using a common protocol and questionnaire because of differences in the use of contraceptive methods and a different concept of pregnancy planning. The distribution of time to pregnancy for the Thai women was not outside the variation found within the European samples.
Wood CO2 efflux in a primary tropical rain forest

The balance between photosynthesis and plant respiration in tropical forests may substantially affect the global carbon cycle. Woody tissue CO2 efflux is a major component of total plant respiration, but estimates of ecosystem‐scale rates are uncertain because of poor sampling in the upper canopy and across landscapes. To overcome these problems, we used a portable scaffolding tower to measure woody tissue CO2 efflux from ground level to the canopy top across a range of sites of varying slope and soil phosphorus content in a primary tropical rain forest in Costa Rica. The objectives of this study were to: (1) determine whether to use surface area, volume, or biomass for modeling and extrapolating wood CO2 efflux, (2) determine if wood CO2 efflux varied seasonally, (3) identify if wood CO2 efflux varied by functional group, height in canopy, soil fertility, or slope, and (4) extrapolate wood CO2 efflux to the forest. CO2 efflux from small diameter woody tissue (<10 cm) was related to surface area, while CO2 efflux from stems >10 cm was related to both surface area and volume. Wood CO2 efflux showed no evidence of seasonality over 2 years. CO2 efflux per unit wood surface area at 25° (FA) was highest for the N‐fixing dominant tree species Pentaclethra macroloba, followed by other tree species, lianas, then palms. Small diameter FA increased steeply with increasing height, and large diameter FA increased with diameter. Soil phosphorus and slope had slight, but complex effects on FA. Wood CO2 efflux per unit ground area was 1.34±0.36 μmol m−2 s−1, or 508±135 g C m−2 yr−1. Small diameter wood, only 15% of total woody biomass, accounted for 70% of total woody tissue CO2 efflux from the forest; while lianas, only 3% of total woody biomass, contributed one‐fourth of the total wood CO2 efflux.
Radio detection of the young binary HD 160934

Context. Precise determination of dynamical masses of pre-main-sequence (PMS) stars is essential to calibrate stellar evolution models that are widely used to derive theoretical masses of young low-mass objects. Binary stars in young, nearby loose associations are particularly good candidates for this calibration since all members share a common age. Interestingly, some of these young binaries present a persistent and compact radio emission, which makes them excellent targets for astrometric VLBI studies. Aims. We aim to monitor the orbital motion of the binary system HD 160934, a member of the AB Doradus moving group. Methods. We observed HD 160934 with the Very Large Array and the European VLBI Network at 8.4 and 5 GHz, respectively. The orbital information derived from these observations was analyzed along with previously reported orbital measurements. Results. We show that the two components of the binary, HD 160934 A and HD 160934 c, display compact radio emission at VLBI scales, providing precise information on the relative orbit. Revised orbital elements were estimated. Conclusions. Future VLBI monitoring of this pair should determine precise model-independent mass estimates for the A and c components, which will serve as calibration tests for PMS evolutionary models. © 2013 ESO.
Muscularis Mucosa of Urinary Bladder Importance for Staging and Treatment

We report the results of a histologic evaluation of muscle (muscularis mucosa) in the lamina propria of the urinary bladder performed on 100 consecutive cystectomy specimens. Muscle fibers were found in the lamina propria lying parallel to the mucosa and forming a distinct muscularis mucosa in three cases; they were interrupted or discontinuous in 20 cases, and dispersed or scattered, forming thin bundles, in 71 cases. In six cases, there were no muscle fibers in the lamina propria. In addition, we noticed that the lamina propria contains large vessels that run along the length of the lamina propria in a continuous or interrupted fashion. When muscle fibers are present, they are associated with these vessels. Since prognosis and management of muscle invasive carcinomas (stage B) is different from that of lamina propria-invasive tumors (stage A), pathologists and urologists should be aware of the presence of a muscularis mucosa in the urinary bladder.
Design of iterative learning controller based on filter to increase the tracking accuracy of repetitive tasks

This paper puts forward the iterative learning control (ILC) function for the existing CNC systems, aiming at the large number of actual need of single-piece repetitive processing tasks. The previous processing error is superimposed on the next processing, with use of the last processing of the control, and gradually improves the processing accuracy, thereby improving the product yield. In the iterative learning processes, the tracking error decreases in the first few cycles and increases to diverge. In order to solve the aforementioned problem, the zero-phase filter is designed to improve this situation. Simulations and hardware in the loop simulation on XY-table demonstrate that the aforementioned problem can be reduced effectively used the proposed method.
Third molars emergence status among 15 to 16 year-old Tanzanian youths.

BACKGROUND Adequate knowledge of timing and pattern of the third molars is essential. The molars are often used to supplement human maturity indicators for school attendance, social benefits, employment, and marriage, differentiating the juvenile from the adult's status in criminal law cases, unidentified cadavers and human remains when birth records are not adequate or not available. BROAD OBJECTIVE: The study was carried out to investigate the emergence status of the third molar tooth among 15 to 16 year-old Tanzanian adolescents. METHODOLOGY A cross-sectional community based study was carried out among secondary school children in Ilala District, Dar es Salaam, Tanzania. This study included 203 adolescents aged 15-16 years old of whom 54% were boys and 46% girls. It was a subsample of randomly selected Tanzanian youths who were part of a larger sample of 869 children from randomly selected 16 schools from different parts of the district covering the whole range of socio-economic background. RESULTS More third molars were already in occlusion in girls (11-13%) than in boys (3-4%) while girls had more third molars emerged into the oral cavity than boys did. The girls had about 15% to 20% of the four third molar teeth emerged in the oral cavity compared to about 3% to 18% in boys. Except for the mandibular right third molar, all the differences in emergence of the third molars between girls and boys were statistically significant. More mandibular third molars had emerged than the corresponding maxillary ones. DISCUSSION AND CONCLUSIONS Third molars were in occlusion in 3-13% of the Tanzanian youths aged 15-16 years indicating earlier emergence than in Caucasian populations. Hence, the need for specific third molars emergence standard tables molars is evident. More studies both cross sectional and longitudinal type involving a larger sample to provide the median and mean ages, rate and pattern of emergence of the third molars in the Tanzanian youth populations are recommended.
Negotiating towards a Next Turn: Phonetic Resources for ‘Doing the Same’

This paper investigates hearers’ use of response tokens (back-channels), in maintaining and differentiating their actions. Initial observations suggest that hearers produce a sequence of phonetically similar responses to disengage from the current topic, and dissimilar responses to engage with the current topic. This is studied systematically by combining detailed interactional and phonetic analysis in a collection of naturally-occurring talk in Norwegian. The interactional analysis forms the basis for labeling actions as maintained (‘doing the same’) and differentiated (‘NOT doing the same’), which is then used as a basis for phonetic analysis. The phonetic analysis shows that certain phonetic characteristics, including pitch, loudness, voice quality and articulatory characteristics, are associated with ‘doing the same’, as different from ‘NOT doing the same’. Interactional analysis gives further evidence of how this differentiation is of systematic relevance in the negotiations of a next turn. This paper addresses phonetic variation and variability by focusing on the relationship between sequence and phonetics in the turn-by-turn development of meaning. This has important implications for linguistic/phonetic research, and for the study of back-channels.
Effects of heat acclimation on hand cooling efficacy following exercise in the heat

ABSTRACT This study examined the separate and combined effects of heat acclimation and hand cooling on post-exercise cooling rates following bouts of exercise in the heat. Seventeen non-heat acclimated (NHA) males (mean ± SE; age, 23 ± 1 y; mass, 75.30 ± 2.27 kg; maximal oxygen consumption [VO2 max], 54.1 ± 1.3 ml·kg−1·min−1) completed 2 heat stress tests (HST) when NHA, then 10 days of heat acclimation, then 2 HST once heat acclimated (HA) in an environmental chamber (40°C; 40%RH). HSTs were 2 60-min bouts of treadmill exercise (45% VO2 max; 2% grade) each followed by 10 min of hand cooling (C) or no cooling (NC). Heat acclimation sessions were 90–240 min of treadmill or stationary bike exercise (60–80% VO2 max). Repeated measures ANOVA with Fishers LSD post hoc (α < 0.05) identified differences. When NHA, C (0.020 ± 0.003°C·min−1) had a greater cooling rate than NC (0.013 ± 0.003°C·min−1) (mean difference [95%CI]; 0.007°C [0.001,0.013], P = 0.035). Once HA, C (0.021 ± 0.002°C·min−1) was similar to NC (0.025 ± 0.002°C·min−1) (0.004°C [−0.003,0.011], P = 0.216). Hand cooling when HA (0.021 ± 0.002°C·min−1) was similar to when NHA (0.020 ± 0.003°C·min−1) (P = 0.77). In conclusion, when NHA, C provided greater cooling rates than NC. Once HA, C and NC provided similar cooling rates.
New insights into the wide ID range channel hot-carrier degradation in high-k based devices

At low energy range, the Lucky Electron Model does not describe correctly the Channel Hot-Carrier (CHC) degradation for transistors with both SiO2 and high-k dielectric. A new picture to explain the CHC degradation behavior in nMOSFETs based on the dominant role of the gate voltage into the total CHC stress is presented.
Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Rapid Identification of Tick Vectors

ABSTRACT A method for rapid species identification of ticks may help clinicians predict the disease outcomes of patients with tick bites and may inform the decision as to whether to administer postexposure prophylactic antibiotic treatment. We aimed to establish a matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) spectrum database based on the analysis of the legs of six tick vectors: Amblyomma variegatum, Rhipicephalus sanguineus, Hyalomma marginatum rufipes, Ixodes ricinus, Dermacentor marginatus, and Dermacentor reticulatus. A blind test was performed on a trial set of ticks to identify specimens of each species. Subsequently, we used MALDI-TOF MS to identify ticks obtained from the wild or removed from patients. The latter tick samples were also identified by 12S ribosomal DNA (rDNA) sequencing and were tested for bacterial infections. Ticks obtained from the wild or removed from patients (R. sanguineus, I. ricinus, and D. marginatus) were accurately identified using MALDI-TOF MS, with the exception of those ticks for which no spectra were available in the database. Furthermore, one damaged specimen was correctly identified as I. ricinus, a vector of Lyme disease, using MALDI-TOF MS only. Six of the 14 ticks removed from patients were found to be infected by pathogens that included Rickettsia, Anaplasma, and Borrelia spp. MALDI-TOF MS appears to be an effective tool for the rapid identification of tick vectors that requires no previous expertise in tick identification. The benefits for clinicians include the more targeted surveillance of patients for symptoms of potentially transmitted diseases and the ability to make more informed decisions as to whether to administer postexposure prophylactic treatment.
Ulcerative colitis and indeterminate colitis in the city of Malmö, Sweden. A 25-year incidence study.

BACKGROUND This study was designed to assess time trends in the incidence of ulcerative colitis and indeterminate colitis in an urban population. METHODS Medical records of in- and out-patients with inflammatory bowel disease were reviewed by a panel to establish the diagnosis. All histopathologic specimens and almost all radiographs were re-examined. RESULTS During the time period 1958 to 1982 there were 354 new cases of definite ulcerative colitis, 117 of probable ulcerative colitis, and 100 of indeterminate colitis. This corresponds to an average annual incidence per 100,000 of 5.5, 1.8, and 1.6, respectively. The incidence was higher in men than in women. Peak incidence was between 20 and 29 years, but indeterminate colitis was most common in 10- to 19-year-old males. The incidence was stable from 1958 to 1972 but then increased in almost all age groups in both sexes. The increase in annual incidence of definite ulcerative colitis from 4.2 to 9.4/10(5) corresponds to an average annual increase of about 5% (p < 0.001). The increase in the incidence of definite ulcerative colitis was due to an increased proportion of patients with proctitis. CONCLUSIONS This study has shown an increased incidence of ulcerative colitis and indeterminate colitis, and we have found no reason to believe that this is a spurious finding.
When dispersal fails: unexpected genetic separation in Gibraltar macaques (Macaca sylvanus)

Barbary macaques (Macaca sylvanus), now restricted in the wild to a few isolated forested areas of Morocco and Algeria, are present in a free‐ranging colony on Gibraltar. For many decades, the Gibraltar colony was exposed to multiple bottlenecks due to highly nonrandom removal of animals, followed by repeated introductions of animals from North Africa. Moreover, because of complete isolation, Gibraltar's several social groups of macaques provide an ideal system to study the genetic consequences of dispersal in cercopithecines in situ. Predictions of genetic consequences due to male‐biased dispersal in cercopithecines will be different for autosomal and maternally inherited genetic markers, such as the control region of the mitochondrial DNA. We used a panel of 14 highly polymorphic microsatellite loci and part of the hypervariable region I of the mitochondrial control region to estimate genetic structure between five social groups in Gibraltar. Surprisingly, for autosomal markers, both classical summary statistics and an individual‐based method using a Bayesian framework detected significant genetic structure between social groups in Gibraltar, despite much closer proximity than wild Algerian and Moroccan populations. Mitochondrial data support this finding, as a very substantial portion of the total genetic variation (70.2%) was found between social groups. Using two Bayesian approaches, we likewise identified not only a small number of male first‐generation immigrants (albeit less than expected for cercopithecines) but also unexpectedly a few females. We hypothesize that the culling of males that are more likely to disperse might slow down genetic homogenization among neighbouring groups, but may also and more perversely produce selection on certain behavioural traits. This may have important repercussions for conservation, as it could lead to evolutionary changes that are not due to inbreeding or genetic drift.