Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Hands-on Learning Stations on Building American Elementary Teachers' Understanding about Earth and Space Science Concepts

Research on conceptual change indicates that not only children, but also teachers have incomplete understanding or misconceptions on science concepts. This mixed methods study was concerned with in-service teachers’ understanding of four earth and space science concepts taught in elementary school: reason for seasons, phases of the moon, rock cycle, and earthquakes. The participants were 29 second year graduate students in an Urban Master Program at a southeastern American university. The data sources were: an open-ended survey given before and after participation in six hands-on learning stations on earth science concepts and teacher reflections in dialogue journals while participating in the stations. Rubrics were used to score answers to each survey question. Findings indicate that in-service teachers have low conceptual understanding of the earth and space science concepts taught in elementary school. Secondly, paired samples t-tests results showed that participation in hands-on stations on these science concepts changed teachers’ understandings of these topics. Finally, dialogue journals contained useful positive reflections, negative reflections, suggestions, and comments on preference to teach the activities in the future. This study has implications for teacher preparation programs, staff development, and conceptual change practices at elementary schools.
Non-Rigid Image Registration With Dynamic Gaussian Component Density and Space Curvature Preservation

Image registration plays an important role in military and civilian applications, such as natural disaster damage assessment, environmental monitoring, ground change detection, and military damage assessment. This paper presents a new feature-based non-rigid image registration method. The main contributions of this paper are: 1) a dynamic Gaussian component density is designed to better exploit available potential image information and provide sufficient inlier pairs for image transformation and 2) a spatial structure preservation, which consists of an image transformation space curvature preservation and a local spatial structure constrain, is proposed to constrain the image transforming cost as well as the local structure of feature points during feature point set registration. The performances of the proposed method in multi-spectral natural images, low-altitude aerial images, and medical images against four types of nine state-of-the-art methods are tested where our method shows the best performances in most scenarios.
Locus Coeruleus tracking of prediction errors optimises cognitive flexibility: An Active Inference model

The locus coeruleus (LC) in the pons is the major source of noradrenaline (NA) in the brain. Two modes of LC firing have been associated with distinct cognitive states: changes in tonic rates of firing are correlated with global levels of arousal and behavioural flexibility, whilst phasic LC responses are evoked by salient stimuli. Here, we unify these two modes of firing by modelling the response of the LC as a correlate of a prediction error when inferring states for action planning under Active Inference (AI). We simulate a classic Go/No-go reward learning task and a three-arm foraging task and show that, if LC activity is considered to reflect the magnitude of high level ‘state-action’ prediction errors, then both tonic and phasic modes of firing are emergent features of belief updating. We also demonstrate that when contingencies change, AI agents can update their internal models more quickly by feeding back this state-action prediction error – reflected in LC firing and noradrenaline release – to optimise learning rate, enabling large adjustments over short timescales. We propose that such prediction errors are mediated by cortico-LC connections, whilst ascending input from LC to cortex modulates belief updating in anterior cingulate cortex (ACC). In short, we characterise the LC/ NA system within a general theory of brain function. In doing so, we show that contrasting, behaviour-dependent firing patterns are an emergent property of the LC’s crucial role in translating prediction errors into an optimal mediation between plasticity and stability. Author Summary The brain uses sensory information to build internal models and make predictions about the world. When errors of prediction occur, models must be updated to ensure desired outcomes are still achieved. Neuromodulator chemicals provide a possible pathway for triggering such changes in brain state. One such neuromodulator, noradrenaline, originates predominantly from a cluster of neurons in the brainstem – the locus coeruleus (LC) – and plays a key role in behaviour, for instance, in determining the balance between exploiting or exploring the environment. Here we use Active Inference (AI), a mathematical model of perception and action, to formally describe LC function. We propose that LC activity is triggered by errors in prediction and that the subsequent release of noradrenaline alters the rate of learning about the environment. Biologically, this describes an LC-cortex feedback loop promoting behavioural flexibility in times of uncertainty. We model LC output as a simulated animal performs two tasks known to elicit archetypal responses. We find that experimentally observed ‘phasic’ and ‘tonic’ patterns of LC activity emerge naturally, and that modulation of learning rates improves task performance. This provides a simple, unified computational account of noradrenergic computational function within a general model of behaviour.
Analysis of rebleeding in cases of an upper gastrointestinal bleed in a single center series.

BACKGROUND upper gastrointestinal bleeding (UGIB) is one of the main causes of hospital admission in gastroenterology departments and is associated with a significant morbidity and mortality. Rebleeding after initial endoscopic therapy occurs in 10-20% of cases and therefore, there is a need to define predictive factors for rebleeding. AIM the aim of our study was to analyze risk factors and outcomes in a population of patients who suffered a rebleed. METHODS five hundred and seven patients with gastrointestinal bleeding were included. Clinical and biochemical data, as well as procedures and outcome six months after admission, were all collected. Documented clinical outcome included in-hospital and six-month delayed mortality, rebleeding and six-month delayed hemorrhagic and cardiovascular events. RESULTS according to a logistic regression analysis, high creatinine levels were independent risk factors for rebleeding of non-variceal and variceal UGIB. In non-variceal UGIB, tachycardia was an independent risk factor, whereas albumin levels were an independent protective factor. Rebleeding was associated with in-hospital mortality (29.5% vs 5.5%; p < 0.0001). In contrast, rebleeding was not related to six-month delayed mortality or delayed cardiovascular and hemorrhagic events. CONCLUSIONS tachycardia and high creatinine and albumin levels were independent factors associated with rebleeding, suggestive of a potential predictive role of these parameters. The incorporation of these variables into predictive scores may provide improved results for patients with UGIB. Further validation in prospective studies is required.
Criminogenic Needs as Intervening Factors in the Relation Between Insecure Attachments and Youth Sexual Violence

There is a strong theoretical and research base demonstrating the link between attachment styles and adolescent sexual offending. However, this relationship may be best explained by deficit-based mediational pathways including criminogenic needs such as emotional or affect regulation and callousness. Grady, Levenson, and Bolder propose a framework that details criminogenic needs as intermediary variables in the attachment–sexual offending relationship. Using data on adolescents adjudicated of sexual and nonsexual crimes in a Western state (N = 200), two structural equation models (SEM) tested direct and indirect relationships between ambivalent and avoidant attachment styles (in separate models), dysregulation including cognitive and behavioral transitions, emotional control, and inhibited/impulsive behaviors, callousness, delinquency, and offending type (sexual or nonsexual offending). Results revealed statistically significant direct pathways between variables of interest and a multimediational effect of dysregulation and callousness in the relationship between insecure attachments and sexual offending. Treatment, policy, and research implications are discussed.
Being the chosen one: social inclusion modulates decisions in the ultimatum game. An ERP study

Abstract In the present study, participants played a modified ultimatum game simulating a situation of inclusion/exclusion, in which either the participant or a rival could be selected to play as the responder. This selection was made either randomly by a computer (i.e. random pairing mode) or by the proposer (i.e. choice mode), based on physical appearance. Being chosen by the proposer triggered positive reciprocal behavior in participants, who accepted unfair offers more frequently than when they had been selected by the computer. Independently of selection mode, greater P200 amplitudes were found when participants received fair offers than when they received unfair offers and when unfair shares were offered to their rivals rather than to them, suggesting that receiving fair offers or observing a rival's misfortune was rewarding for participants. While participants generally showed more interest in the offers they themselves received (i.e. greater P300 responses to these offers), observing their rivals receive fair shares after the latter had been chosen by the proposer triggered an increase in P300 amplitude likely to reflect a feeling of envy. This study provides new insights into both the cognitive and affective processes underpinning economic decision making in a context of social inclusion/exclusion.
Radiation-Induced Rhinitis: Cytological and Olfactory Changes

Background Oral mucositis is a well-known adverse event of radiotherapy (RT) for head and neck cancer (HNC). Its nasal counterpart, the radiation-induced rhinitis, is poorly studied and considered in clinical practice. Objective The aim of this observational study was to evaluate acute cytological and olfactory alterations during RT and their correlation with RT doses. Methods Ten patients who underwent RT for HNC, excluding tumors of the nasal cavities, were evaluated with nasal scraping for cytological examination, Sniffin’ Sticks test for olfactory assessment, and Nasal Obstruction Symptom Evaluation scale. The examinations were performed before (T0), at mid-course (T1), and at the end (T2) of RT. They were repeated 1 and 3 months after RT (T3 and T4). Mean dose (Dmean) and near maximum dose (D2%) to nasal cavities and inferior turbinates were used for correlation analyses. Results Radiation-induced rhinitis was present in 70% of patients at T2, and it was still observed in 40% of cases after 3 months. Although olfactory function remained within the normal range at the evaluated times, a significant decrease in odor threshold and discrimination was observed during RT, which returned to baseline levels after RT. Nasal cytology showed a radiation-induced rhinitis with neutrophils and sometimes bacteria. Mucous and squamous cell metaplasia appeared in 10% of patients. Dmean and D2% to inferior turbinates were associated to neutrophilic rhinitis at T2, and D2% to inferior turbinates was correlated to mucous cell metaplasia at T2. Conclusions RT for HNC induces acute rhinitis that may persist after the completion of treatment and can affect patient’s quality of life. Nasal cytology can help to choose the best treatment on an individual basis.
Different Pathways Leading up to the Same Futsal Competition: Individual and Inter-Team Variability in Loading Patterns and Preseason Training Adaptations

During the preseason, futsal players deal with large internal load, which may result in a reduction in physical performance. The aims of this study were to compare the session rating of perceived exertion training load (s-RPE TL) during the preseason between two teams; and to analyze the changes on the delayed-onset muscle soreness (DOMS), aerobic- and speed-power characteristics in players accumulating different s-RPE TL (Low (LTL) vs. High (HTL)). Twenty-eight players (Team A, n = 15; Team B, n = 13) were recruited. The s-RPE TL was monitored throughout the preseason phase (five weeks) in both teams. The coaches of each team planned the activities that comprised their training programs, without any interference from the researchers. Team A evaluated countermovement jumps (CMJ) and DOMS weekly. Team B performed squat jumps (SJ), CMJ, 5 m and 15 m sprints, and a futsal intermittent endurance test (PVFIET) before and after the preseason. Team B accumulated an almost-certainly greater s-RPE TL than Team A. In Team A, the CMJ height was likely to almost certainly improved for the HTL group from week 3. In Team B, the 5 m and 15 m sprint likely decreased after the preseason. Changes in 5 m (r = −0.61) and 15 m (r = −0.56) were correlated with total s-RPE TL. Changes in PVFIET were positively associated with changes in sprint, but inversely related to the baseline. s-RPE TL differed between both teams, and substantial gains in neuromuscular performance were observed for the HTL group in Team A. Slower and faster players in Team B showed distinct intermittent-endurance and speed adaptive responses during the high-volume preseason.
Abnormalities in P300 components in depression: an ERP-sLORETA study

Abstract Background: Alterations in P300 components occur in depressed patients, but the brain regions contributing to these changes remain unclear. Aims: Thus, the aim of the present study was to examine the underlying neural activation of P300 components in patients with depression to explore brain regions related to depression. Methods: P300 components were evoked by an oddball auditory paradigm and recorded from 30 patients with current depression, as well as 30 age-, gender-, and education level-matched healthy controls. The standardized Low-Resolution Brain Electromagnetic Tomography (sLORETA) method was used to explore the source activation of P300 components. Results: Compared with healthy controls, depressed patients tended to exhibit lower P200 and P300 amplitudes and prolonged P300 latency. In depressed patients, P200 source activations were reduced in the right insula, right precentral gyrus, left anterior cingulate, medial frontal gyrus, superior frontal gyrus, and middle frontal gyrus. Decreased source activations of P300 were identified in the right insula, postcentral gyrus, superior temporal gyrus, inferior parietal lobule, transverse temporal gyrus, cingulate gyrus, precentral gyrus, middle frontal gyrus, superior frontal gyrus, medial frontal gyrus, and paracentral gyrus. Conclusions: Extensive dysfunction over the right hemisphere and bilateral prefrontal dysfunction may be involved in the pathophysiology of depression.
Ages-at-death distribution of the early Pleistocene hominin fossil assemblage from Drimolen (South Africa).

OBJECTIVES A prevailing hypothesis in paleoanthropology is that early Pleistocene hominin bones were accumulated in South African caves by carnivores, which used those shelters, and the trees surrounding them, as refuge and feeding sites. We tested this hypothesis at the site of Drimolen, by comparing its hominin age-at-death distribution to that of the nearby and roughly contemporaneous site of Swartkrans. MATERIALS AND METHODS We employed standard dental aging systems in order to categorize the Drimolen hominin teeth into age classes of 5 years each. We then compared the age-at-death distribution for Drimolen with the published data available for the Swartkrans hominins. RESULTS Age-at-death distributions indicate that the age category "young adults" is the best represented age category at Swartkrans and the most poorly represented one at Drimolen. Moreover, Drimolen has a preponderance of infant specimens. Both sites have a low frequency of old adult specimens. CONCLUSIONS Differences observed in frequencies of the age-at-death categories suggest different mechanisms of hominin skeletal accumulation at Drimolen and Swartkrans. Swartkrans' frequency curve reflects mortality in a population subjected to predation and is thus consistent with the carnivore-accumulating hypothesis. In contrast, the Drimolen curve is similar to that of wild populations of living apes. Living primates have been observed exploiting caves as sleeping shelters, for nutritional, security, drinking, and thermoregulatory purposes. We suggest that similar cave use by Pleistocene hominins can explain, in large part, the accumulation of hominin bones at Drimolen. Such a conclusion is another illustration of the growing awareness that a "one-size-fits-all" taphonomic model for South African early Pleistocene hominin sites is probably insufficient.
Extracellular CIRP (eCIRP) and inflammation

Cold‐inducible RNA‐binding protein (CIRP) was discovered 2 decades ago while studying the mechanism of cold stress adaptation in mammals. Since then, the role of intracellular CIRP (iCIRP) as a stress‐response protein has been extensively studied. Recently, extracellular CIRP (eCIRP) was discovered to also have an important role, acting as a damage‐associated molecular pattern, raising critical implications for the pathobiology of inflammatory diseases. During hemorrhagic shock and sepsis, inflammation triggers the translocation of CIRP from the nucleus to the cytosol and its release to the extracellular space. eCIRP then induces inflammatory responses in macrophages, neutrophils, lymphocytes, and dendritic cells. eCIRP also induces endoplasmic reticulum stress and pyroptosis in endothelial cells by activating the NF‐κB and inflammasome pathways, and necroptosis in macrophages via mitochondrial DNA damage. eCIRP works through the TLR4‐MD2 receptors. Studies with CIRP−/− mice reveal protection against inflammation, implicating eCIRP to be a novel drug target. Anti‐CIRP Ab or CIRP‐derived small peptide may have effective therapeutic potentials in sepsis, acute lung injury, and organ ischemia/reperfusion injuries. The current review focuses on the pathobiology of eCIRP by emphasizing on signal transduction machineries, leading to discovering novel therapeutic interventions targeting eCIRP in various inflammatory diseases.
Meaning in life is associated with the psychopathology of eating disorders: differences depending on the diagnosis

ABSTRACT Previous studies indicated that meaning in life was inversely associated with eating behaviors and a negative attitude toward food, body satisfaction, and borderline symptoms. However, research on the association between meaning in life and eating disorder psychopathology is scarce, and there are no studies on the association between meaning in life and the eating disorder psychopathology depending on the diagnosis. The aim of the present study is to verify whether meaning in life is differentially associated with a broad range of psychopathology symptoms commonly observed in people with ED, depending on the diagnosis, in a sample of 240 ED patients. We found that meaning in life was negatively associated with eating behaviors and a negative attitude toward food, body satisfaction, borderline symptoms, and hopelessness in all types of eating disorders, regardless of the specific diagnosis. Moreover, the association with meaning in life was different depending on the type of eating disorders. Specifically in the participants with Anorexia Nervosa Restrictive, meaning in life had a higher percentage of explained variance in the eating disorders psychopathology (between 30% and 65%). Therefore, these results seem to indicate that, although meaning in life is an important variable in all the eating disorders subtypes, it is especially relevant in participants with the Anorexia Nervosa Restrictive subtype.
Cooperative subunit dynamics modulate p97 function

Significance Mutations in the highly conserved hexameric p97 enzyme are associated with a series of diseases affecting muscle, bone, and brain, and have been linked to changes to the orientation of the N-terminal domain (NTD) in each p97 subunit. Although studies have focused on p97 constructs where all protomers are WT or all contain a disease-causing mutation, a strong body of evidence suggests that p97 molecules are heterogeneous, containing a mixture of these subunits in patients. We have used solution NMR to study such heterohexameric structures, showing that the NTD conformation of a disease mutant can be somewhat remedied by WT neighbors, leading to a partial restoration of interactions with adaptor molecules. The mechanism of this allosteric process is investigated. p97 is an essential hexameric AAA+ ATPase involved in a wide range of cellular processes. Mutations in the enzyme are implicated in the etiology of an autosomal dominant neurological disease in which patients are heterozygous with respect to p97 alleles, containing one copy each of WT and disease-causing mutant genes, so that, in vivo, p97 molecules can be heterogeneous in subunit composition. Studies of p97 have, however, focused on homohexameric constructs, where protomers are either entirely WT or contain a disease-causing mutation, showing that for WT p97, the N-terminal domain (NTD) of each subunit can exist in either a down (ADP) or up (ATP) conformation. NMR studies establish that, in the ADP-bound state, the up/down NTD equilibrium shifts progressively toward the up conformation as a function of disease mutant severity. To understand NTD functional dynamics in biologically relevant p97 heterohexamers comprising both WT and disease-causing mutant subunits, we performed a methyl-transverse relaxation optimized spectroscopy (TROSY) NMR study on a series of constructs in which only one of the protomer types is NMR-labeled. Our results show positive cooperativity of NTD up/down equilibria between neighboring protomers, allowing us to define interprotomer pathways that mediate the allosteric communication between subunits. Notably, the perturbed up/down NTD equilibrium in mutant subunits is partially restored by neighboring WT protomers, as is the two-pronged binding of the UBXD1 adaptor that is affected in disease. This work highlights the plasticity of p97 and how subtle perturbations to its free-energy landscape lead to significant changes in NTD conformation and adaptor binding.