Miracle-dz/UniFAR-FTUs huggingface dataset:
Locative sentences and related constructions in Catalan: Esser / Haver alternation

This article will illustrate the argument structure and the syntactic behavior of Catalan locative or existential verbs. It will also be concerned with the properties of the functional category Agreement-subject. Following Rigau (1991), it will be argued that Agreement-s can be split into two functional categories: Agreement-person and Agreement-number. Agreement-person is the category that licenses nominative case and, in some circumstances, dative case. Agreement-number was defined in Rigau (1991, 1994) as the category that manifests the relation between the verb and its prominent argument; namely, Agreement-number is the functional category where the Extended Projection Principle feature (Chomsky 1995) has to be satisfied. Therefore, a divorce is assumed between the functional category that licences the case properties of the subject of the sentence and the category that provides a prominent argument for the sentence. Generally, the external argument of the predicate is the DP that checks nominative case in Agreement-person and the EPP feature in Agreement-numberP. Nevertheless, in the sentences I will analyze, the argument that checks its case in Agreement-person may be different from the argument that checks the EPP feature in Agreement-NumberP. Catalan has two locative or existential verbs: the verb isser (or ser) 'be' and the verb haver 'have'. The verb haver appears obligatorily with the clitic hi: haver-hi. In essential accordance with Bach (1967), Fillmore (1968), Freeze (1992) and Kayne (1993), it will be argued that the Catalan locative verb haver-hi is an instance of the light verb isser to which an abstract preposition has been incorporated. Both verbs act as a host verb, in the sense that they are in the sentence to help the real predicate. The predicate in locative sentences is a preposition, an abstract or overt preposition.
Combined Transphyseal and Lateral Extra-articular Pediatric Anterior Cruciate Ligament Reconstruction: A Novel Technique to Reduce ACL Reinjury While Allowing for Growth

Background: Treatment of anterior cruciate ligament (ACL) injuries in the adolescent population continues to be complicated by an unacceptably high rate of secondary ACL injury. Purpose: To describe the failure rate and outcomes after a hybrid pediatric ACL reconstruction (ACLR) employing transphyseal hamstring (TPH) autograft combined with an extra-articular technique using an iliotibial band (ITB) autograft. Study Design: Case series; Level of evidence, 4. Methods: Consecutive patients undergoing combined TPH-ITB ACLR between January 2012 and April 2017 with a minimum 2-year follow-up were reviewed. With the goal of decreasing ACL graft injury in this high-risk group, this technique employed anteromedial portal drilling for TPH with an extraosseous femoral ITB technique and intra-articular TPH-ITB grafts fixed within the tibial bone tunnel. Demographics, bone age, standing alignment radiograph for growth and mechanical axis grade, return to sport, graft failure, and patient-reported outcome measures were analyzed. Results: A total of 61 knees in 60 adolescents underwent the combined TPH-ITB ACLR, with 57 knees (93.4%) meeting inclusion criteria with a mean follow-up of 38.5 months (range, 24-78 months). Only 3 of 57 knees (5.3%) sustained ACL reinjury. The mean age was 13.0 years (range, 11-16 years) with 36 male patients (mean bone age, 14.2 years) and 21 female patients (mean bone age, 13.3 years), and 91% of patients (52 of 57) returned to sport. Participants demonstrated a high functional level at final follow-up, with a mean score of 91.2 (range, 46.7-100) on the Pediatric International Knee Documentation Committee (Pedi-IKDC) Subjective Knee Evaluation Form and mean score of 22.4 (range, 4-30) on the Pediatric Functional Activity Brief Scale (Pedi-FABS). To critically assess growth, a cohort with ≥18 months of growth remaining at surgery was evaluated at maturity. No difference was seen in mean operative and nonoperative leg growth (49.7 mm and 49.8 mm). Although no family reported cosmetic or functional alignment or length concerns, 1 of 18 (5.5%) had a final limb length discrepancy >10 mm (12 mm) and a perioperative alignment difference (0-Grade II valgus). Conclusion: Combined TPH-ITB ACLR in adolescents resulted in high activity levels (Pedi-FABS, 22.4; median, 25) and a low (5.3%) graft failure rate at a mean 38.5 months.
Predicting Software Self Efficacy among Business Students: A Preliminary Assessment

An empirical study was conducted to investigate demographic predictors of software self-efficacy among undergraduate business students. The relationship between academic major, gender, ACT scores, computer-related experience, family income, and computer anxiety level with software self-efficacy was investigated. The results indicate significant differences in software self-efficacy among students with different majors, amounts of computerrelated experience, family income levels, and computer anxiety levels. Although significant differences between students from families with different income levels were found, however no clear patterns were discernable.
Developing a model for solving the flight perturbation problem

Purpose: In the aviation and airline industry, crew costs are the second largest direct operating cost next to the fuel costs. But unlike the fuel costs, a considerable portion of the crew costs can be saved through optimized utilization of the internal resources of an airline company. Therefore, solving the flight perturbation scheduling problem, in order to provide an optimized schedule in a comprehensive manner that covered all problem dimensions simultaneously, is very important. In this paper, we defined an integrated recovery model as that which is able to recover aircraft and crew dimensions simultaneously in order to produce more economical solutions and create fewer incompatibilities between the decisions. Design/methodology: Current research is performed based on the development of one of the flight rescheduling models with disruption management approach wherein two solution strategies for flight perturbation problem are presented: Dantzig-Wolfe decomposition and Lagrangian heuristic. Findings: According to the results of this research, Lagrangian heuristic approach for the DW-MPsolved the problem optimally in all known cases. Also, this strategy based on the Dantig-Wolfe decomposition manage to produce a solution within an acceptable time (Under 1 Sec). Originality/value: This model will support the decisions of the flight controllers in the operation centers for the airlines. When the flight network faces a problem the flight controllers achieve a set of ranked answers using this model thus, applying crew’s conditions in the proposed model caused this model to be closer to actual conditions
A retrospective study to determine the cefepime-induced neurotoxicity threshold in hospitalized patients.

OBJECTIVES Cefepime-induced neurotoxicity (CIN) has been demonstrated to be associated with cefepime plasma concentrations; however, the toxicity threshold remains unclear. The primary objective of this study was to identify the cefepime plasma trough concentration at which neurotoxicity occurs. Secondary objectives were to determine the incidence of CIN at a large tertiary institution and to identify patient factors associated with the development of CIN. METHODS A retrospective review of all adult patients administered cefepime between October 2017 and May 2018 in a tertiary hospital was conducted to determine total incidence of CIN. A receiver operating characteristic (ROC) curve was constructed to review the sensitivity and specificity of using various cefepime trough plasma concentrations to predict the development of neurotoxicity. Cefepime plasma concentrations were measured using ultra-HPLC. A regression was conducted to identify patient factors associated with CIN. RESULTS In total, 206 patients were administered 259 courses of cefepime, with an overall CIN incidence of 6% (16/259 courses). A total of 64 courses had a cefepime trough concentration measured (24.7%). A cefepime trough concentration of 36 mg/L provided the best differentiation between patients who experienced neurotoxicity and those who did not. No other patient covariates were identified to be significantly associated with neurotoxicity occurring. CONCLUSIONS A cefepime trough plasma concentration ≥36 mg/L appears to be the most sensitive and specific cut-off to predict CIN occurring. No patient factors were associated with the development of CIN when accounting for cefepime trough plasma concentrations.
Use of a process analysis tool for diagnostic study on fine particulate matter predictions in the U.S. – Part I: Model evaluation

Abstract Regional ozone (O3) and fine particles (PM2.5) modeling for both research–grade and regulation applications is important due to their known impacts on human health, air quality, and climate change. In this study, the fifth– generation Penn State/NCAR Mesoscale Model (MM5) and the U.S. EPA Models–3/Community Multiscale Air Quality (CMAQ) modeling system are applied to simulate the major air pollutants during the 1999 Southern Oxidants Study episode for the period of 12–28 June 1999. As Part I of two companion papers describing CMAQ performance, process analysis, and sensitivity simulations, this paper presents results from an operational evaluation for meteorological and chemical predictions using the available surface, aircraft, and satellite data. Both MM5 and CMAQ show reasonable performance for major meteorological variables (i.e., temperature, relative humidity, wind direction, planetary boundary layer height) with normalized mean biases (NMBs) of 0.4–24.2%, surface concentrations O3, PM2.5, SO42–, and NH4+ with NMBs of –39% to 24.2%, and vertical profiles of temperature and sulfur dioxide. Relatively poor performance is found in the simulated precipitation (NMBs of –16.3% to 37.4%), the concentrations of NO3–, EC, and OC (NMBs of –77.8% to –22%) and total O3 column mass. The evaluation identifies several research areas that are needed to improve model performance for nitrate, organic carbon, and black carbon at surface, vertical profiles of relative humidity, carbon monoxide, and nitrogen oxides, and tropospheric O3 column abundance.
Spatial Accuracy of a Clinically Established Noninvasive Electrocardiographic Imaging System for the Detection of Focal Activation in an Intact Porcine Model.

BACKGROUND Noninvasive electrocardiographic imaging (ECGi) is used clinically to map arrhythmias before ablation. Despite its clinical use, validation data regarding the accuracy of the system for the identification of arrhythmia foci is limited. METHODS Nine pigs underwent closed-chest placement of endocardial fiducial markers, computed tomography, and pacing in all cardiac chambers with ECGi acquisition. Pacing location was reconstructed from biplane fluoroscopy and registered to the computed tomography using the fiducials. A blinded investigator predicted the pacing location from the ECGi data, and the distance to the true pacing catheter tip location was calculated. RESULTS A total of 109 endocardial and 9 epicardial locations were paced in 9 pigs. ECGi predicted the correct chamber of origin in 85% of atrial and 92% of ventricular sites. Lateral locations were predicted in the correct chamber more often than septal locations (97% versus 79%, P=0.01). Absolute distances in space between the true and predicted pacing locations were 20.7 (13.8-25.6) mm (median and [first-third] quartile). Distances were not significantly different across cardiac chambers. CONCLUSIONS The ECGi system is able to correctly identify the chamber of origin for focal activation in the vast majority of cases. Determination of the true site of origin is possible with sufficient accuracy with consideration of these error estimates.
Mental illness and bipolar disorder on Twitter: implications for stigma and social support

Abstract Background: Mental illness (MI), and particularly, bipolar disorder (BD), are highly stigmatized. However, it is unknown if this stigma is also represented on social media. Aims: Characterize Twitter-based stigma and social support messaging (“tweets”) about mental health/illness (MH)/MI and BD and determine which tweets garnered retweets. Methods: We collected tweets about MH/MI and BD during a three-month period and analyzed tweets from dates with the most tweets (“spikes”), an indicator of topic interest. A sample was manually content analyzed, and the remainder were classified using machine learning (logistic regression) by topic, stigma, and social support messaging. We compared stigma and support toward MH/MI versus BD and used logistic regression to quantify tweet features associated with retweets, to assess tweet reach. Results: Of the 1,270,902 tweets analyzed, 94.7% discussed MH/MI and 5.3% discussed BD. Spikes coincided with a celebrity’s death and a MH awareness campaign. Although the sample contained more support than stigma messaging, BD tweets contained more stigma and less support than MH/MI tweets. However, stigma messaging was infrequently retweeted, and users often retweeted personal MH experiences. Conclusions: These findings demonstrate opportunities for social media advocacy to reduce stigma and increase displays of social support towards people living with BD.
Emission Reductions of Carbonyl Compounds in a Heavy-Duty Diesel Engine Supplemented with H2/O2 Fuel

Carbonyl compounds play an important role in atmospheric chemistry, and have adverse effects on human health because they are precursors of ozone and peroxyacyl nitrates. This study investigated the emissions of carbonyl compounds from a heavy-duty diesel engine (HDDE) at one low load steady-state condition (24.5% of the max load at 40 km/h). The experimental results indicate that the emissions of total carbonyl concentrations decreased by 4.7% to 32.3% when 10 to 70 L/min H2/O2 mixture was added to neat diesel fuel. The emissions of nine individual carbonyl species also decreased. Among these, formaldehyde was the major species, accounting for 80.4%–81.5% of the total concentrations in the exhausts of all tested fuels, and its emissions were reduced from 5.1% to 31.7%. Meanwhile, the emission factors of total carbonyl compounds, in mg/L, decreased from 3.6% to 13.0%, and those of total carbonyl compounds, in mg/kWh, decreased from 4.6% to 32.3%. These results indicate that the addition of a H2/O2 mixture to neat diesel fuel can reduce emissions form diesel engines to the atmosphere.
High temperature combined with drought affect rainfed spring wheat and barley in south-eastern Russia: Yield, relative performance and heat susceptibility index

Among all abiotic stresses, drought is undoubtedly the major factor, which, individually or combined with heat stress, limits crop productivity worldwide. Considering these facts, four spring barley and two spring wheat genotypes were evaluated under two stress (early and late) conditions in a southern arid region of Russia in order to identify suitable spring wheat and barley genotypes for that region and to assess the optimum sowing time for specific genotypes. High temperature followed by deficit soil moisture affected all stages from germination through to reproduction of crop when sown late, finally drastically reducing yield. On the other hand, due to low temperature, germination and stand establishment of crop sown early were highly affected, resulting in lower grain yield. Thus, high temperature (air and soil) followed by drought (deficit soil moisture) in the late-sown crop (from germination to reproductive stages) and low temperature in germination through vegetative stages of the early-sown crop are the most important constraints for crop production in this arid region. From the overall performance (yield, relative performance and stress susceptibility index), genotype ‘Zernograd.770’ is recommended for both early and late drought stressed areas and ‘Ratnik’ were sensitive to stress both at low temperatures when sown early and high temperatures followed by drought when sown late. Key words: High temperature, drought, spring wheat, barley, Russia.
Identification of Class 1 Integron of Escherichia coli from Street Foods in Jakarta

A total of 43 Escherichia coli isolates were identified from school street foods located in Northern and Southern Jakarta. The isolates were examined for antibiotic resistance using five antibiotics discs (ampicillin, kanamycin, streptomycin, trimethoprim, tetracycline) and screened for the class 1 integron with specific conserved region primer using PCR amplification. The antibiotic diffusion test revealed three isolates (7%) with resistance to multiple antibiotics. PCR detection of integron regions showed one isolate possessed a class 1 integron bearing one gene cassette with ~700bp amplicon size. DNA sequencing showed that the gene cassette was resistant to trimethoprim determinant type V (dhfrV). The integron bearing E. coli strain could become a threat for the widespread distribution of an antibiotic resistance gene especially for pathogenic bacteria. Poor sanitation of school’s street foods (that are obtained from street vendors outside schools), which is commonly found in Indonesia, may lead to the disease that could risk millions of children health. Therefore, Escherichia coli is an important food hygiene indicator to access the quality of street foods. The presence of E. coli also shows the probability of contamination by enteric pathogenic bacteria, like Salmonella sp. , Vibrio sp. , or Enteropathogenic E. coli (EPEC) (Stiles and King 1981).
lncRNA FENDRR Exhibits Anti-Fibrotic Activity in Pulmonary Fibrosis.

RATIONALE Abnormal activation of lung fibroblasts contributes to the initiation and progression of idiopathic pulmonary fibrosis (IPF). OBJECTIVES The objective of the current study was to investigate the role of FENDRR in the activation of lung fibroblasts. METHODS Dysregulated lncRNAs in IPF lungs were identified by next generation sequencing analysis from the two online datasets. FENDRR expression in lung tissues from patients with IPF and mice with bleomycin-induced pulmonary fibrosis was determined by quantitative real-time polymerase chain reaction. Iron-responsive element-binding protein 1 (IRP1), a protein partner of FENDDR, was identified by RNA pulldown-coupled mass spectrometry analysis and confirmed by RNA immunoprecipitation. The interaction region between FENDRR and IRP1 was determined by cross-linking immunoprecipitation. The in vivo role of FENDRR in pulmonary fibrosis was studied using adenovirus-mediated gene transfer in mice. MEASUREMENTS AND MAIN RESULTS The expression of FENDRR was down-regulated in fibrotic human and mouse lungs as well as primary lung fibroblasts isolated from bleomycin-treated mice. TGFβ1-SMAD3 signaling inhibited FENDRR expression in lung fibroblasts. FENDRR was preferentially localized in the cytoplasm of adult lung fibroblasts and bound IRP1, suggesting its role in iron metabolism. FENDRR reduced pulmonary fibrosis by inhibiting fibroblast activation by reducing iron level and acting as a competing endogenous RNA of the profibrotic miR-214. Adenovirus-mediated FENDRR gene transfer in the mouse lung attenuated bleomycin-induced lung fibrosis and improved lung function. CONCLUSIONS Our data suggest that FENDRR is an anti-fibrotic lncRNA and a potential therapeutic target for pulmonary fibrosis.
A new catalogue of Galactic novae: investigation of the MMRD relation and spatial distribution

In this study, a new Galactic novae catalogue is introduced collecting important parameters of these sources such as their light curve parameters, classifications, full width half maximum (FWHM) of H$_\alpha$ line, distances and interstellar reddening estimates. The catalogue is also published on a website with a search option via a SQL query and an online tool to re-calculate the distance/reddening of a nova from the derived reddening-distance relations. Using the novae in the catalogue, the existence of a maximum magnitude-rate of decline (MMRD) relation in the Galaxy is investigated. Although an MMRD relation was obtained, a significant scattering in the resulting MMRD distribution still exists. We suggest that the MMRD relation likely depends on other parameters in addition to the decline time, as FWHM H$_\alpha$, the light curve shapes. Using two different samples depending on the distances in the catalogue and from the derived MMRD relation, the spatial distributions of Galactic novae as a function of their spectral and speed classes were studied. The investigation on the Galactic model parameters implies that best estimates for the local outburst density are 3.6 and 4.2 $\times 10^{-10}$ pc$^{-3}$ yr$^{-1}$ with a scale height of 148 and 175 pc, while the space density changes in the range of $0.4 - 16 \ \times 10^{-6}$ pc$^{-3}$. The local outburst density and scale height obtained in this study infer that the disk nova rate in the Galaxy is in the range of $\sim20$ to $\sim100$ yr$^{-1}$ with an average estimate $67^{+21}_{-17}$ yr$^{-1}$.
Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients.

Aim: Germline variants could modify survival of metastatic colorectal cancer patients (mCRC). Patients & methods: The association of 285 haplotype-tagging single nucleotide polymorphisms in 11 candidate genes and overall survival (OS) was tested in two cohorts totalizing 417 FOLFIRI-treated mCRC. Gene expression was investigated in vitro and in public datasets. Results: In the combined cohort, CES1 rs9921399T>C was associated with prolonged OS (hazard ratio [HR] = 0.40) whereas ABCC1 rs17501011G>A (HR = 2.08) and UGT1 rs1113193G>A (HR = 2.12) were associated with shorter OS (p ≤ 0.005). A combined effect of these polymorphisms was observed with HR of 1.98-2.97 (p < 0.05). The ABCC1 rs17501011A variant reduced reporter-gene activity (p < 0.05) whereas ABCC1 tumor expression was associated with shorter survival (p ≤ 0.013). Conclusion: We identified a combination of genetic determinants that could predict mCRC survival.
A randomized controlled trial on ambulatory blood pressure lowering effect of CPAP in patients with obstructive sleep apnea and nocturnal hypertension

Abstract Objective: In a randomised controlled trial, we investigated the blood pressure (BP) lowering effect of continuous positive airway pressure (CPAP) in patients with moderate-severe obstructive sleep apnoea syndrome (OSAS, an apnoea-hypopnoea index, AHI of 15 or higher) and nocturnal hypertension (night-time systolic/diastolic BP ≥120/70 mmHg). Methods: Sixty patients were randomly assigned to CPAP or sham CPAP, while maintaining their antihypertensive treatment. Ambulatory BP monitoring was performed at baseline (first run-in visit) and the end of follow-up. Clinic and home BP were measured at baseline and each of the monthly follow-up visits. Results: Of the 60 patients, 47 completed the 3-month study. CPAP (n = 26), compared with sham CPAP (n = 21), slightly and non-significantly reduced 24-h systolic/diastolic BP by −2.8/−2.5 mmHg (p ≥ 0.27), with a slightly greater between-group difference in the daytime (−4.0/−2.8 mmHg, p ≥ 0.29) than night-time (−0.2/−1.5 mmHg, p ≥ 0.50). The CPAP treatment did not significantly influence clinic or home BP during follow-up (p ≥ 0.27). Nonetheless, simple and partial correlation analyses showed that the ambulatory BP lowering effect was dependent on the daytime pulse rate at baseline (r ≥ 0.47, p ≤ 0.01). In patients with a daytime pulse rate greater than 85 beats/min, the mean changes in daytime systolic BP were significantly greater in the CPAP (n = 10) than sham CPAP group (n = 11), with a between-group mean difference of −10.1 mmHg (p = 0.048). Conclusions: The CPAP treatment did not show significant ambulatory BP lowering effect in patients with moderate-severe OSAS and nocturnal hypertension. However, it may be effective in lowering daytime BP in patients with a faster pulse rate.