Miracle-dz/UniFAR-FTUs huggingface dataset:
PHYLOGENETIC ANALYSIS AND PREVALENCE OF HUMAN PAPILLOMAVIRUS (HPV) IN WOMEN WITH SEVERAL CERVICAL PATHOLOGIES

and HPV type 16 specific probe. HPV types determinate by GP5+/GP6+. Phylogenetic analysis of sequences was calculated by Kimura's two parameters method. Statistically analyses were by using Pearson chi-square and odss ratio tests. Results: Forty seven samples (prevalence; 61%) of total seventy seven cervical samples detected as HPV DNA positive. While HPV type 16; 52%, HPV type 16+11; 4%, HPV type 16+6; 1% and non-typing HPV DNA 4% of seventy seven samples determining, 39% of samples observed as negative HPV. Participated in the study population, HPV DNA positive individuals are among 34-56 years. Most HPV DNA positivity rate of 80.0% was between the ages of 3140. 52.2% of HPV DNA positivity between the ages of 41-50 to fall, but again, 83.3% between the ages of 51-60 to a second peak was determined that increased. 60.0% of 20 ASC-H cases, 63.8% of 36 ASC-US cases, 100% 9 of HSIL cases and 25.0% of 12 LSIL cases were positive for HPV DNA. Conclusion: The investigation of the distribution of HPV genotypes in women with cervical cancer and precancerous lesions in our region is important. Early diagnosis of HPV by using improved technological assays, play a key role to prevent the turn precancerous lesions into invasive cancers.
Elevated C‐reactive protein in Native Canadian children: an ominous early complication of childhood obesity

Aim: Subclinical inflammation has been proposed as a pathophysiologic mechanism linking obesity with vascular and metabolic disease. Native North American populations are experiencing high prevalence rates of both (i) childhood obesity and (ii) adult cardiovascular disease (CVD) and type 2 diabetes. Thus, we sought to determine whether subclinical inflammation is an early complication of obesity in Native children.
The Black Woman and the Problem of Gender: An African Perspective

Une investigation ethnologique sur les differents degres de sexisme social, politique, economique et religieux dans les traditions culturelles africaines (Dahomey, Niger, Ethiopie, Afrique du Sud.) et les moyens permettant de parvenir a l'emancipation de la femme noire - notamment a travers une androgynisation des reformes economiques et politiques de l'Afrostroika
Actitudes ante la discapacidad en el alumnado universitario matriculado en materias afines

Las actitudes hacia las personas con discapacidad por parte de los profesionales implicados, directa e indirectamente, en su atención es un factor primordial en el proceso de integración de estas personas. Sin embargo, no es usual tener en cuenta las actitudes hacia la discapacidad en el diseño curricular destinado a estudiantes universitarios que serán, en poco tiempo, los profesionales encargados de satisfacer las necesidades asistenciales de esta población. En este contexto, el presente trabajo pretende aportar datos empíricos sobre las actitudes ante la discapacidad en el alumnado universitario matriculado en materias relacionadas, en sus contenidos, con la asistencia directa a este colectivo. Para ello, se ha aplicado, y analizado los datos, de una escala específica a una muestra de 498 estudiantes de la Universidad de Sevilla (España). Los resultados muestran que la actitud hacia las personas discapacitadas es globalmente positiva y que factores como poseer experiencia en el contacto con ellas favorece aún más este extremo. Por el contrario, variables como el género, el tipo de titulación o la frecuencia o razón del contacto, no parecen que influyan en la actitud hacia la discapacidad. Por último, también se analizan las relaciones que guardan estas variables entre sí y las repercusiones para la práctica educativa que se derivan de éstas.
High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?

15-Oxygenated cholesterol species such as 5α-cholest-8(14)ene-3β,15α-diol (15HC) and 3β-hydroxy-5α-cholest-8(14)-en-15-one (15KC) are commercially available synthetic products unlikely to occur in biological systems. Surprisingly, Farez et al. recently reported that these two steroids occur in human circulation at levels considerably higher than those of any other endogenous oxysterol [Farez, M. et al. 2009. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat. Immunol. 10: 958–964]. The levels were reported to be increased in patients with multiple sclerosis in a progressive phase and the authors suggested that this could be utilized diagnostically. Based on extensive in vitro experiments exposing cells to the same high levels of 15HC as found in vivo (1000 ng/ml) the authors concluded that 15HC may be an important pathogenetic factor in multiple sclerosis. Using combined gas chromatography-mass spectrometry we fail to detect significant plasma levels of 15HC either in healthy controls or in patients with multiple sclerosis (levels < 2 ng/ml). If 15KC is present in these plasma samples, the concentration of it must be <10 ng/ml. Our failure to detect significant levels of the above steroids could not be due to loss during hydrolysis and work-up because recovery of the added two oxysterols was close to 100%. Autoxidation of lipoprotein-bound cholesterol resulted in extensive conversion of cholesterol into 7-oxygenated but not 15-oxygenated sterols. We conclude that if present there are trace amounts only of the above 15-oxygenated steroids in human circulation and that the role of such oxysterols as pathogenetic factors and biomarkers must be reconsidered.
Transmission, reservoir hosts and control of zoonotic visceral leishmaniasis

SUMMARY Zoonotic visceral leishmaniasis (ZVL) caused by Leishmania infantum is an important disease of humans and dogs. Here we review aspects of the transmission and control of ZVL. Whilst there is clear evidence that ZVL is maintained by sandfly transmission, transmission may also occur by non-sandfly routes, such as congenital and sexual transmission. Dogs are the only confirmed primary reservoir of infection. Meta-analysis of dog studies confirms that infectiousness is higher in symptomatic infection; infectiousness is also higher in European than South American studies. A high prevalence of infection has been reported from an increasing number of domestic and wild mammals; updated host ranges are provided. The crab-eating fox Cerdocyon thous, opossums Didelphis spp. , domestic cat Felis cattus, black rat Rattus rattus and humans can infect sandflies, but confirmation of these hosts as primary or secondary reservoirs requires further xenodiagnosis studies at the population level. Thus the putative sylvatic reservoir(s) of ZVL remains unknown. Review of intervention studies examining the effectiveness of current control methods highlights the lack of randomized controlled trials of both dog culling and residual insecticide spraying. Topical insecticides (deltamethrin-impregnated collars and pour-ons) have been shown to provide a high level of individual protection to treated dogs, but further community-level studies are needed.
Anaesthesia care for emergency endoscopy for peptic ulcer bleeding. A nationwide population-based cohort study

ABSTRACT Objective: Currently, no standard approach exists to the level of monitoring or presence of staff with anaesthetic expertise required during emergency esophago-gastro-duodenoscopy (EGD) for peptic ulcer bleeding (PUB). We assess the association between anaesthesia care and mortality. We further describe the prevalence and inter-hospital variation of anaesthesia care in Denmark and identify clinical predictors for choosing anaesthesia care. Material and methods: This population-based cohort study included all emergency EGDs for PUB in adults during 2012–2013. About 90-day all-cause mortality after EGD was estimated by crude and adjusted logistic regression. Clinical predictors of anaesthesia care were identified in another logistic regression model. Results: Some 3.056 EGDs performed at 21 hospitals were included; 2074 (68%) received anaesthesia care and 982 (32%) were managed under supervison of the endoscopist. Some 16.7% of the patients undergoing EGD with anaesthesia care died within 90 days after the procedure, compared to 9.8% of the patients who had no anaesthesia care, adjusted OR = 1.51 (95% CI = 1.25–1.83). Comparing the two hospitals with the most frequent (98.6% of al EGDs) and least frequent (6.9%) use of anaesthesia care, mortality was 13.7% and 11.7%, respectively, adjusted OR = 1.22 (95% CI = 0.55–2.71). The prevalence of anaesthesia care varied between the hospitals, median = 78.9% (range 6.9–98.6%). Predictors of choosing anaesthesia care were shock at admission, high ASA score, and no pre-existing comorbidity. Conclusions: Use of anaesthesia care for emergency EGD was associated with increased mortality, most likely because of confounding by indication. The use of anaesthesia care varied greatly between hospitals, but was unrelated to mortality at hospital level.
The immune epitope database: a historical retrospective of the first decade

As the amount of biomedical information available in the literature continues to increase, databases that aggregate this information continue to grow in importance and scope. The population of databases can occur either through fully automated text mining approaches or through manual curation by human subject experts. We here report our experiences in populating the National Institute of Allergy and Infectious Diseases sponsored Immune Epitope Database and Analysis Resource (IEDB, http://iedb.org), which was created in 2003, and as of 2012 captures the epitope information from approximately 99% of all papers published to date that describe immune epitopes (with the exception of cancer and HIV data). This was achieved using a hybrid model based on automated document categorization and extensive human expert involvement. This task required automated scanning of over 22 million PubMed abstracts followed by classification and curation of over 13 000 references, including over 7000 infectious disease‐related manuscripts, over 1000 allergy‐related manuscripts, roughly 4000 related to autoimmunity, and 1000 transplant/alloantigen‐related manuscripts. The IEDB curation involves an unprecedented level of detail, capturing for each paper the actual experiments performed for each different epitope structure. Key to enabling this process was the extensive use of ontologies to ensure rigorous and consistent data representation as well as interoperability with other bioinformatics resources, including the Protein Data Bank, Chemical Entities of Biological Interest, and the NIAID Bioinformatics Resource Centers. A growing fraction of the IEDB data derives from direct submissions by research groups engaged in epitope discovery, and is being facilitated by the implementation of novel data submission tools. The present explosion of information contained in biological databases demands effective query and display capabilities to optimize the user experience. Accordingly, the development of original ways to query the database, on the basis of ontologically driven hierarchical trees, and display of epitope data in aggregate in a biologically intuitive yet rigorous fashion is now at the forefront of the IEDB efforts. We also highlight advances made in the realm of epitope analysis and predictive tools available in the IEDB.
Cervical Muscle Dysfunction in the Chronic Whiplash Associated Disorder Grade II (WAD-II)

Study Design. In a cross-sectional study, surface electromyography measurements of the upper trapezius muscles were obtained during different functional tasks in patients with a chronic whiplash associated disorder Grade II and healthy control subjects. Objectives. To investigate whether muscle dysfunction of the upper trapezius muscles, as assessed by surface electromyography, can be used to distinguish patients with whiplash associated disorder Grade II from healthy control subjects. Summary of Background Information. In the whiplash associated disorder, there is need to improve the diagnostic tools. Whiplash associated disorder Grade II is characterized by the presence of “musculoskeletal signs. ” Surface electromyography to assess these musculoskeletal signs objectively may be a useful tool. Methods. Normalized smoothed rectified electromyography levels of the upper trapezius muscles of patients with whiplash associated disorder Grade II (n = 18) and healthy control subjects (n = 19) were compared during three static postures, during a unilateral dynamic manual exercise, and during relaxation after the manual exercise. Coefficients of variation were computed to identify the measurement condition that discriminated best between the two groups. Results. The most pronounced differences between patients with whiplash associated disorder Grade II and healthy control subjects were found particularly in situations in which the biomechanical load was low. Patients showed higher coactivation levels during physical exercise and a decreased ability to relax muscles after physical exercise. Conclusions. Patients with whiplash associated disorder Grade II can be distinguished from healthy control subjects according to the presence of cervical muscle dysfunction, as assessed by surface electromyography of the upper trapezius muscles. Particularly the decreased ability to relax the trapezius muscles seems to be a promising feature to identify patients with whiplash associated disorder Grade II. Assessment of the muscle (dys)function by surface electromyography offers a refinement of the whiplash associated disorder classification and provides an indication to a suitable therapeutic approach.
A randomized controlled trial of rivastigmine in patients with cognitive impairment no dementia because of cerebrovascular disease

Narasimhalu K, Effendy S, Sim CH, Lee JM, Chen I, Hia SB, Xue HL, Corrales MP, Chang HM, Wong MC, Chen CP, Tan EK. A randomized controlled trial of rivastigmine in patients with cognitive impairment no dementia because of cerebrovascular disease. Acta Neurol Scand: 2010: 121: 217–224. © 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard.
Improving M-Commerce Services Effectiveness with the Use of User-Centric Content Delivery

Advances in wireless communications and information technology have made the Mobile Web a reality. The Mobile Web is the response to the need for anytime, anywhere access to information and services. Many wireless applications have already been deployed and are available to customers via their mobile phones and wirelessly-connected PDAs. However, as communications and other IT usage becomes an integral part of many peopleâ€™s lives and the available products and services become more varied and capable, users expect to be able to personalize a service to meet their individual needs and preferences. The involved sectors have to meet these challenges by reengineering their front-end and back-end office. This article will examine the interaction requirements regarding a friendlier, personalized and more effective multi-channel services environment. It will present the mobility challenges and constraints implemented into the business sector, investigating the current m-commerce situation and the extended user characteristics presenting a high level user-centric m-commerce architecture.
Correlates of fatigue during and following adjuvant breast cancer chemotherapy: a pilot study.

PURPOSE/OBJECTIVES To examine patterns of and relationships between activity, sleep, symptom distress, health status, and fatigue during and following adjuvant breast cancer chemotherapy with doxorubicin and cyclophosphamide. DESIGN Prospective, descriptive, repeated measures. SETTING Midwestern, urban, oncology clinics. SAMPLE 14 women, ages 32-69 (X = 52.4), with stage I or II breast cancer receiving four cycles of chemotherapy. METHODS Wrist actigraph, modified Morin Sleep Diary, Symptom Experience Scale, Medical Outcomes Study-Short Form 36, and Piper Fatigue Scale were used to collect data two days prior to and during the 21-day cycle 3, and for three days at three weeks and two months following treatment 4. MAIN RESEARCH VARIABLES Activity, sleep, symptom distress, health status, and fatigue. FINDINGS Fluctuating patterns of lowered activity, disturbed sleep, mild-to-moderate symptom distress, and moderate fatigue were identified. Mean activity levels ranged from 65%-80% of norms during and following treatments. Patterns of sleep (total rest, sleep latency, wake after sleep onset, and sleep efficiency) differed from established norms. Patients experienced the highest levels of fatigue and symptom distress during the first four days after treatment 3. Correlates of fatigue were greater symptom distress, lower activity, and poorer physical and social health status; variables representing disturbed sleep trended toward associations with fatigue. CONCLUSION Activity, sleep, symptom distress, and health status cluster in patterns associated with either lower or higher fatigue. IMPLICATIONS FOR NURSING PRACTICE Efforts to manage symptoms, remain active, and obtain quality sleep, especially in women with poorer health status, may assist in modifying fatigue.
CryptSQLite: Protecting Data Confidentiality of SQLite with Intel SGX

Protecting data confidentiality for database systems is a critical but challenging problem. In this paper, we propose a novel architecture to address this problem by combining Intel Software Guard Extensions (SGX) technology and the symmetric encryption scheme. Based on the proposed architecture, we use SQLite, a lightweight database system, as a study case and propose CryptSQLite to protect its data confidentiality. Our security analysis showed that CryptSQLite can protect the data confidentiality against attacks from outside attackers, malicious insiders, and malicious neighboring users. We further developed a prototype system based on the design. Our experimental results showed that CryptSQLite is a viable solution and incurs a moderate performance overhead.
The influence of chromosome content on the size and shape of sperm heads in Drosophila melanogaster and the demonstration of chromosome loss during spermiogenesis.

The volumes of sperm heads were estimated from three-dimensional reconstructions of serially sectioned bundles of nearly mature spermatid nuclei. Cysts from males in which all sperm are expected to have comparable amounts of chromatin (X/Y and 1n(3LR)/+) show unimodal frequency distributions of nuclear volumes, whereas cysts from males in which meiotic segregation is expected to deliver unequal amounts of chromatin material to spermatid nuclei show two (XY/O and XY/Y) or more (T(2;3)/+ ANd C(2L);C(2R)) modes. The mean volumes of the subpopulations in these cases are related in the same proportions as the metaphase lengths of their chromosomal complements. Thus the volumes of sperm nuclei are proportional to their DNA content. Sperm head shape, on the other hand, does not appear to be very sensitive to chromosomal constitution, as heads of different size do not vary greatly in shape. ----The numbers of sperm heads in the various size classes in a cyst depart from mendelian expectations; these departures are caused by the elimination, during individualization, of chromosomes contained within micronuclei that are formed in spermatids at the end of the second meiotic division. The effect of this chromosome loss is to increase the proportion of nullosomic gametes in the sperm pool. ----The relative frequencies of XY-bearing and nullo-X, nullo-Y sperm in XY/O males were estimated from the volume measurements. Taking this estimate as a measure of the fertilizing population, it is possible to infer from the change in sex ratio over time following insemination, that XY-bearing sperm have an advantage of 1.5 over nullo-X, nullo-Y sperm in leaving the seminal receptacle of the female for fertilization of ova.
Preoperative and Postoperative Instability in Lumbar Spinal Stenosis

Sixty-one patients operated on for spinal stenosis, without a fusion, were studied retrospectively. Preoperative instability, as revealed by functional myelography, was found to predict a poor prognosis (P < 0.01). Women had less favorable results (P < 0.05). The “slipping” group was significantly more often radically decompressed than the “nonslipping” group (P < 0.01). Postoperative slipping was found in 26 patients, significantly more often in those with unsatisfactory results (P < 0.001).
Value Creation and Value Appropriation: An Integrative, Multi-Level Framework

Value creation by individuals and firms plays a central role in the evolution of populations by enabling adaptive efficiency. Once created, value may become embedded in resources which require deployment for value to be appropriated. Value appropriation is a two-step process through which a firm first competes against other firms to create and protect appropriation streams (i.e., inter-organizational value appropriation), then managers, employees, shareholders and other stakeholders compete to capture the value that has been retained within the firm (i.e., intra-organizational value appropriation). I argue that the inter- and intra-organizational value appropriation processes are driven by common elements, including not only bargaining power and isolating mechanisms but also relation-based power and opportunity-based action. I advocate an integrative approach due to the interplay between value creation and value appropriation processes.
Pillar of Fire : America in the King Years 1963-65

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THE TRANSCENDENTAL MEDITATION PROGRAM AND REHABILITATION : A PILOT PROJECT AT THE FEDERAL CORRECTIONAL INSTITUTION AT LOMPOC , CALIFORNIA

The Transcendental Meditation program was examined as a possible solution to the difficult problem of inmate rehabilitation. Spielberger's State-Trait Anxiety Inventory was administered to prisoners at the Federal Correctional Institution at Lompoc, California, twice before and twice after they learned the Transcendental Meditation technique. At the final testing they were also administered a Shelly Questionnaire and a Likert Scale to assess self-perceived personality changes. At both pretest sessions (four and one-half weeks and one to two days before the experimental group received instruction in the Transcendental Meditation technique), the mean transitory and general anxiety test scores of the experimental subjects were insignificantly different from those of a comparison group of nonmeditating inmates. At the first posttest (six weeks after beginning Transcendental Meditation), the meditators showed anxiety scores significantly below the prison norm (p < .001 for transitory anxiety; p < .001 for general anxiety). This marked reduction in anxiety was maintained at the second posttest 15 weeks after Transcendental Meditation was begun (p < .001 for transitory anxiety; p < .001 for general anxiety). Regularity of meditation was correlated with reduction in anxiety. The Likert Scale administered at the second posttest session suggested positive personality changes in the meditating inmates. Comments elicited by a questionnaire indicated enthusiastic acceptance of the Transcendental Meditation program by the inmates. Because anxiety is associated with the most common problems facing inmates, and because Transcendental Meditation markedly reduces anxiety, the Transcendental Meditation program shows great promise for rehabilitation programs.