Miracle-dz/UniFAR-FTUs huggingface dataset:
Resistance to Insecticides and Effect of Synergists on Permethrin Toxicity in Pediculus capitis (Anoplura: Pediculidae) from Buenos Aires

Abstract Permethrin-resistant colonies of Pediculus capitis (De Geer) from Buenos Aires were used to establish a resistance profile and to examine resistance mechanisms. All permethrin-resistant head lice (resistance ratio from 52.8 to >88.7) were also resistant to d-phenothrin (resistance ratio from 40.86 to >48.39) and deltamethrin (resistance ratio from 16.24 to 38.06). No cross-resistance to carbaryl was found in any of the pyrethroid-resistant P. capitis tested. Otherwise, all resistant colonies showed low to high levels of resistance to β-cypermethrin. This pyrethroid had never been applied as a pediculicide in Argentina; however, the high level of resistance found in these permethrin-resistant colonies (resistance ratio from 9.74 to 50.97) demonstrated that pyrethroid cross-resistance occurred to this novel insecticide. Treatment with piperonyl butoxide (PBO) or triphenylphosphate (TPP) significantly decreased the toxicity of permethrin in the four colonies tested. The esterase inhibitor TPP produced lower enhancement of toxicity than the multifunction oxidase inhibitor PBO in the colonies having the highest resistance levels. Results presented here concerning the cross-resistance profile and synergism by enzyme inhibitors in permethrin-resistant head lice demonstrated that enhanced metabolism was involved in the pyrethroid resistance. However, the substantial degree of resistance that remained after synergism suggested the presence of another resistance mechanism. Cross-resistance to pyrethroid and susceptibility to the carbamate carbaryl suggested a common action mechanism.
A Social History of Late Ottoman Women: New Perspectives

TABLE OF CONTENTS Dedication Acknowledgement List of Illustrations Introduction Duygu Koeksal, Anastasia Falierou PART I: Women as Economic Actors: Class, Work and Social Issues Theater as Career for Ottoman Armenian Women, 1850 to 1910 Hasmik Khalapyan Searching for Women's Agency in the Tobacco Workshops: Female Tobacco Workers of the Province of Selanik E. Tutku Vardagli Working From Home: Division of Labor Among Female Workers of Feshane in Late Nineteenth Century Istanbul M. Erdem Kabadayi PART II: Education for Life: Schools, Associations and Curricula The Limits of Feminism in Muslim-Turkish Women Writers of the Armistice Period Elif Ikbal Mahir Metinsoy Between Two Worlds: Education and Accultration of Ottoman Jewish Women Rachel Simon Girls' Institutes and the Rearrangement of the Public and the Private Spheres in Turkey Elif Ekin Aksit PART III: Creating New Lives, Pushing the Boundaries: Ottoman Female Artists Painting the Late Ottoman Woman: Portrait(s) of Mihri Musfik Hanim Burcu Pelvanoglu The New Woman in Erotic Popular Literature of 1920s Istanbul Fatma Ture PART IV: Womanhood in Print Culture Enlightened Mothers and Scientific Housewifes: Discussing Women's Social Roles in Eurydice (Evridiki) (1870-1873) Anastasia Falierou An Almanac for Ottoman Women: Notes on Ebuzziya Tevfik's Takvimu'n-nisa (1317/1899) OEzgur Turesay Women's Representations in Ottoman Cartoons and the Satirical Press on the Eve of the Kemalist Reforms (1919-1924) Francois Georgon Part V: Dilemmas of Nationalism: Debating Modernity, Identity and Women's Agency From a Critique of the Orient to a Critique of Modernity: A Greek-Ottoman-American Writer, Demetra Vaka (1877-1946) Duygu Koeksal The 'Tomboy' and the Aristocrat: Nabawiyya Musa and Malak Hifni Nasif, Pioneers of Egyptian Feminism Catherine Mayeur-Jaouen Hayriye Melek (Hunc), a Circassian Ottoman Writer between Feminism and Nationalism Alexandre Toumarkine Notes on Contributors Index
Renal functional reserve in healthy elderly subjects.

The increase in GFR after an amino acid (AA) load, the so-called renal functional reserve, is impaired in the aged rat. Whether the renal functional reserve predicts the progression of renal disease in humans is controversial, but it is possible that age-related alterations of renal hemodynamics are relevant for the evolution of renal disease in the elderly. We compared renal hemodynamics before and after an AA infusion in 15 healthy normotensive subjects of young age (seven women, eight men; median age, 26 yr; range, 23 to 32) and in 10 subjects of old age (six women, four men; median age, 70 yr; range, 61 to 82) on normal dietary protein intake. Baseline GFR and effective RPF were measured after 12 h of fasting by the inulin (Cin) and para-aminohippurate (Cpah) steady-state infusion techniques. The renal functional reserve was examined after an overnight AA infusion (7% solution; 83 mL/h). Median basal Cin and Cpah were significantly lower (P < 0.01) in the elderly (102 and 339 mL/min per 1.73 m2) than in the young subjects (122 and 647 mL/min per 1.73 m2), but virtually all GFR values of the elderly were still within the normal range. Median Cin upon infusion of AA was 118 mL/min per 1.73 m2 (range, 98 to 137) in the elderly and 146 (range, 120 to 171) in the young, respectively. Corresponding values of Cpah were 349 mL/min per 1.73 m2 in the elderly versus 689 mL/min per 1.73 m2 in the young. Cin increased significantly (P < 0.01) after the AA load in both young and elderly subjects. (ABSTRACT TRUNCATED AT 250 WORDS)
I see happy people: Attention bias towards happy but not angry facial expressions in Williams syndrome

Introduction. Observations of behaviour and research using eyetracking technology have shown that individuals with Williams syndrome (WS) pay an unusual amount of attention to other people's faces. The present research examines whether this attention to faces is moderated by the valence of emotional expression. Method. Sixteen participants with WS aged between 13 and 29 years (mean = 19 years 9 months) completed a dot-probe task in which pairs of faces displaying happy, angry, and neutral expressions were presented. The performance of the WS group was compared to two groups of typically developing control participants, individually matched to the participants in the WS group on either chronological age or mental age. General mental age was assessed in the WS group using the Woodcock-Johnson Test of Cognitive Ability–Revised (WJ-COG-R; Woodcock & Johnson, 1989/1990). Results. Compared to both control groups, the WS group exhibited a greater attention bias for happy faces. In contrast, no between-group differences in bias for angry faces were obtained. Conclusions. The results are discussed in relation to recent neuroimaging findings and the hypersocial behaviour that is characteristic of the WS population.
Cerebrovascular complications in patients with inflammatory bowel disease.

UNLABELLED Cerebrovascular complications in 9 patients with inflammatory bowel disease (IBD) are presented, 6 with Crohn's disease (CD) and 3 with ulcerative colitis (UC), 7 men and 2 women, mean age 36.5 +/- 3.5 years, 4 of them during acute disease. Cerebrovascular complications were: cerebral venous thrombosis (CVT)--7 cases (5 CD and 2 UC) and ischemic stroke--2 cases (1 CD and 1 UC). Out of 7 cases with CVT 5 were superior sagittal sinus thrombosis (SSS), 2 SSS and transverse and sigmoid sinus thrombosis. Both ischemic strokes were infarctions in the middle cerebral artery area. No correlation between high doses of corticosteroids or their lowering, IBD activity, duration of the disease, and the appearance of cerebrovascular complications was observed. Tendency to hypercoagulation even in the inactive stage of the IBD was revealed. Investigations for thrombophilia were negative. Significantly high levels of homocysteine were observed in all patients. CONCLUSION Neurovascular complications may be observed in IBD, both of venous and arterial type. Pathogenic mechanisms of these vascular complications are complex, low serum folate levels, of vitamin B6 and B12 being associated with elevation of homocysteine levels, high activation of platelets and microvascular endothelial dysfunction. A guide for the orientation of prophylaxis of cerebrovascular complications in IBD patients is necessary.
The Impact of Small Group Case-based Learning on Traditional Pharmacology Teaching.

OBJECTIVES This study aimed to measure medical students' perceptions of incorporating small group case-based learning (CBL) in traditional pharmacology lectures. METHODS Data were collected from third-year students (N = 68; 57% males, 43% females) at Al Quds University Medical School, Palestine. The students were offered a CBL-incorporated Pharmacology-2 course after they had been taught Pharmacology-1 in the traditional format during the preceding semester. Student attitudes towards the restructured course were examined by a self-administered structured questionnaire. RESULTS The majority of students thought that CBL was an effective learning tool for them (82%) and that it improved their learning skills (83%), independent learning skills (74%), analytical skills (70%), and their level of preparation for exams (75%). Most students reported that team discussions addressed lecture objectives (84%). Regarding cases discussed, most responders said that the cases were appropriate to the lecture topics (96%) and that the time allocated for case discussion was sufficient (86%). A large proportion of students thought that CBL improved their communication and collaborative skills (68% and 80%, respectively) and ability to work within a team (79%). CONCLUSION Pharmacology-2 course restructuring led to a significant improvement of self-reported student satisfaction, motivation, and engagement.
A virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16.

BACKGROUND Previous studies have demonstrated that genital infection with high-risk types of human papillomavirus (HPV), most often HPV16, is the most significant risk factor for the development of cervical cancer. However, serologic assays that have been developed to identify high-risk HPV infection have either failed to associate serum reactivity with other indicators of HPV infection or have identified only a minority of HPV-infected individuals. PURPOSE Our purpose was to determine whether a specifically developed enzyme-linked immunosorbent assay (ELISA) could detect IgG anti-HPV16 virion antibodies in the sera of women who had tested positive for genital HPV16 infection by DNA-based methods. METHODS An ELISA was developed using newly developed HPV16 virus-like particles as antigens to detect anti-HPV16 virion IgG antibodies. These particles are comprised of HPV16 structural proteins that are self-assembled in insect cells after expression by recombinant baculoviruses. The sera of 122 women, whose HPV status had been previously evaluated by nucleic acid-based methods, were tested by this ELISA. RESULTS The sera of 59% of women (32 of 54) positive for genital HPV16 DNA by polymerase chain reaction (PCR) were positive in the ELISA assay compared with sera from women who had tested negative for HPV DNA (P < .0005). In contrast, 6% of HPV DNA-negative women (two of 31) and 9% of women positive for low-risk HPV6/11 DNA (one of 11) were ELISA positive by this criterion. The sera of women who were DNA positive for two additional high-risk HPV types were evaluated; the sera of 31% of HPV18-positive (four of 13) and 38% of HPV31-positive women (five of 13) were positive in the HPV16 particle ELISA. The sera of 75% of HPV16 DNA-positive women with severe dysplasias (12 of 16) gave positive ELISA results. The sera of 67% of women (28 of 42) who tested positive for HPV16 DNA by both PCR and the less sensitive ViraType assay tested positive in the ELISA compared with 33% of women (four of 12) who were positive by PCR but negative by ViraType (P < .05). CONCLUSION The majority of women with cervical HPV16 infection generate an IgG antibody response to conformationally dependent epitopes of HPV16 L1 that can be detected by ELISA. IMPLICATION This particular ELISA, or a similar one incorporating virus-like particles of additional HPV types, may be useful in determining the natural history of high-risk HPV infection and perhaps help to identify women at risk for developing cervical cancer.
Dimethyl Fumarate Inhibits Dendritic Cell Maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-regulated Kinase 1 and 2 (ERK1/2) and Mitogen Stress-activated Kinase 1 (MSK1) Signaling*

Background: Dimethyl Fumarate (DMF) treatment leads to a reduction in IFN-γ+CD4+ T (Th1) cells in patients with multiple sclerosis. Results: DMF reduces the antigen-presenting capacity of dendritic cells (DCs) via suppression of NF-κB and ERK1/2-MSK1 signaling. Conclusion: DMF impaired DC maturation, resulting in decreased Th1 and Th17 cell differentiation. Significance: This study defined one of the molecular mechanisms of DMF in inflammatory diseases. Dimethyl fumarate (DMF) is an effective novel treatment for multiple sclerosis in clinical trials. A reduction of IFN-γ-producing CD4+ T cells is observed in DMF-treated patients and may contribute to its clinical efficacy. However, the cellular and molecular mechanisms behind this clinical observation are unclear. In this study, we investigated the effects of DMF on dendritic cell (DC) maturation and subsequent DC-mediated T cell responses. We show that DMF inhibits DC maturation by reducing inflammatory cytokine production (IL-12 and IL-6) and the expression of MHC class II, CD80, and CD86. Importantly, this immature DC phenotype generated fewer activated T cells that were characterized by decreased IFN-γ and IL-17 production. Further molecular studies demonstrated that DMF impaired nuclear factor κB (NF-κB) signaling via reduced p65 nuclear translocalization and phosphorylation. NF-κB signaling was further decreased by DMF-mediated suppression of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and its downstream kinase mitogen stress-activated kinase 1 (MSK1). MSK1 suppression resulted in decreased p65 phosphorylation at serine 276 and reduced histone phosphorylation at serine 10. As a consequence, DMF appears to reduce p65 transcriptional activity both directly and indirectly by promoting a silent chromatin environment. Finally, treatment of DCs with the MSK1 inhibitor H89 partially mimicked the effects of DMF on the DC signaling pathway and impaired DC maturation. Taken together, these studies indicate that by suppression of both NF-κB and ERK1/2-MSK1 signaling, DMF inhibits maturation of DCs and subsequently Th1 and Th17 cell differentiation.
Measuring the Real-Ear to Coupler Difference Transfer Function With an Insert Earphone and a Hearing Instrument: Are They the Same?

Objective: The purpose of the study was to compare the real-ear to coupler difference (RECD) measured with an insert earphone and two models of hearing instrument. Design: The RECD was obtained from one ear of 18 normal-hearing subjects by subtracting the 2-cc coupler (HA1 and HA2) response from a real-ear aided response, using a conventional probe-tube microphone system. The measurements were made with a conventional ER-3A earphone and two models of behind-the-ear hearing instrument (Unitron US80, Unitron, Kitchener, Canada; and Widex Diva, Widex, Vaerloese, Denmark). Results: The procedures were very reliable, with mean differences on retest of less than 1 dB. There were statistically significant differences between the mean RECDs obtained using an insert earphone compared with those obtained with each hearing instrument (p < 0.05). The differences were greatest when using the HA2 2-cc coupler. For example, the maximum difference in mean RECD between the insert earphone and the Widex Diva was 6 dB and 11 dB when using the HA1 and the HA2 2-cc coupler, respectively. Conclusions: The RECD is dependent on the acoustic impedance of the sound source, the coupling system, and the coupler and ear. The acoustic impedance may be different for an insert earphone and a given hearing instrument. Therefore, the RECD measured with an insert earphone may not always accurately represent the difference in performance of a hearing instrument measured in the real ear and the 2-cc coupler.
Varying family planning strategies across age categories: differences in factors associated with current modern contraceptive use among youth and adult women in Luanda, Angola

Background The objective of this study is to identify factors associated with current modern contraceptive use among Angolan women. By differentiating according to age groups (15–24 and 25–49 years), this study aimed to help family planning program planners better tailor interventions to improve utilization of modern contraception. Methods A household survey was used to collect data from 1,545 women of reproductive age living in Luanda Province, Angola. Data on sociodemographic characteristics, reproductive behavior and intentions, contraceptive knowledge and use, and attitudes and beliefs regarding contraception and abortion were collected. The analyses were stratified based on age: 15–24 years (youth) and 25–49 years (adult). Multivariate logistic regression models were built for each age group, adding different subsets of variables in groups to see how relationships changed across the models. Results Common factors associated with modern contraceptive use among all ages include education level, perceived contraceptive accessibility, contraceptive knowledge, communication with partner about family planning in last year, and self-efficacy. Exposure to family planning information in the media in the last few months, perceived partner approval of family planning, and marital status were all positively associated with current modern contraceptive use among women aged 15–24 years. Meanwhile, receiving information about family planning from a pharmacy in the last year was uniquely associated with current modern contraceptive use among women aged 25–49 years. Conclusion Young women in Luanda, Angola seem to have a unique set of factors affecting their contraceptive use. These findings highlight the need for family planning programs to cater services and messages toward specific age groups.
Antisense RNA Inhibition of the β Subunit of the Dictyostelium discoideum Mitochondrial Processing Peptidase Induces the Expression of Mitochondrial Proteins

We cloned and characterized a cDNA encoding the Dictyostelium discoideum β subunit of mitochondrial processing peptidase (Ddβ-MPP). Western blot analysis of the mitochondrial subfractions revealed that Ddβ-MPP is located in the mitochondrial matrix and membrane, whereas Ddα-MPP, another subunit of DdMPP, is located only in the matrix. Although expression of Ddβ-MPP mRNA is down-regulated during early development, the level of the Ddβ-MPP protein is constant throughout the Dictyostelium life cycle. In a transformant expressing the antisense RNA of the β-MPP gene, unexpectedly, the β-MPP protein increased about 1.8-fold relative to the wild type, and its mRNA increased 4.5-fold. Expression of other mitochondrial proteins, α-MPP and Cox IV, was also induced. These results suggest that antisense RNA inhibition of the β-MPP gene induces gene expression of mitochondrial proteins, presumably in a retrograde signaling manner. This is the pathway of the transfer of information from the mitochondria to the nucleus.
Trends in the prevalence of transfusion-transmissible infections among blood donors in Albania.

BACKGROUND The objective of this study is to determine the trend of transfusion transmitted infection in blood donors. METHODS In this study 52727 blood donors were retrospectively evaluated for markers of hepatitis B, C, HIV(1/2), and syphilis. To screen the blood donors for HIV(1/2)(HIV(1/2) Ag/Ab COMBO, ABBOTT Laboratory, Delkenheim, Germany), the microparticle enzyme immunoassay (MEIA) method was used. For HBsAg and anti-HCV third generation MEIA kits (ABBOTT Laboratory, Delkenheim, Germany) were used and for the syphilis RPR test the Biokit SA (Barcelona, Spain) was used. RESULTS A total of 52,727 donors were tested within the five year period, of which 15 (0.03%), 3531 (6.7%), 323 (0.6%), and 35 (0.07%) were positive for HIV, HBV, HCV, and syphilis, respectively. The prevalence of TTI in blood donors was 7.4%. It increased steadily from 5.1% in 2004 to 8.3% in 2006, stayed in same level in 2007, and decreased to 8.1% in 2008. Distribution of transfusion-transmissible infection (TTI) based on donor status was 13.8% in first time commercial remunerated blood donors, 9.4% in first time voluntary blood donors, and 9.7% in family replacement blood donors. CONCLUSIONS Our results in this study showed that family replacement donors are more likely to transmit transfusion-transmissible infections (TTIs) than voluntary donors, but are safer than commercial blood donors. So blood transfusion services should work on replacement of family blood donors with voluntary non-remunerated blood donors.
Checklists change communication about key elements of patient care

BACKGROUND Combat casualty care is distributed across professions and echelons of care. Communication within it is fragmented, inconsistent, and prone to failure. Daily checklists used during intensive care unit (ICU) rounds have been shown to improve compliance with evidence-based practices, enhance communication, promote consistency of care, and improve outcomes. Checklists are criticized because it is difficult to establish a causal link between them and their effect on outcomes. We investigated how checklists used during ICU rounds affect communication. METHODS We conducted this project in two military ICUs (burn and surgical/trauma). Checklists contained up to 21 questions grouped according to patient population. We recorded which checklist items were discussed during rounds before and after implementation of a “must address” checklist and compared the frequency of discussing items before checklist prompting. RESULTS Patient discussions addressed more checklist items before prompting at the end of the 2-week evaluation compared with the 2-week preimplementation period (surgical trauma ICU, 36% vs. 77%, p < 0.0001; burn ICU, 47% vs. 72 %, p < 0.001). Most items were addressed more frequently in both ICUs after implementation. Key items such as central line removal, reduction of laboratory testing, medication reconciliation, medication interactions, bowel movements, sedation holidays, breathing trials, and lung protective ventilation showed significant improvements. CONCLUSION Checklists modify communication patterns. Improved communication facilitated by checklists may be one mechanism behind their effectiveness. Checklists are powerful tools that can rapidly alter patient care delivery. Implementing checklists could facilitate the rapid dissemination of clinical practice changes, improve communication between echelons of care and between individuals involved in patient care, and reduce missed information. Level of Evidence Therapeutic/care management study, level III.