Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of VEGF and FGF2 on the Revascularization of Severed Human Dental Pulps

The long-term outcome of replanted avulsed permanent teeth is frequently compromised by lack of revascularization, resulting in pulp necrosis. The purpose of this study was to evaluate the effects of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF-2) on the revascularization of severed human dental pulps. Tooth slices were prepared from non-carious human molars and treated with 0–50 ng/mL rhVEGF165 or rhFGF-2 for 7 days in vitro. Both angiogenic factors enhanced pulp microvessel density compared with untreated controls (p < 0.05). Tooth slices were also treated with 0 or 50 ng/mL rhVEGF165 for one hour prior to implantation into the subcutaneous space of immunodeficient mice. Treatment with rhVEGF165 increased pulp microvessel density in vivo (p < 0.05). These results demonstrate that rhVEGF165 enhanced neovascularization of severed human dental pulps and suggest that topical application of an angiogenic factor prior to replantation might be beneficial for the treatment of avulsed teeth.
Health Improvements and the Transition Out of Malthusian Stagnation

The central component of most economic models that analyse the transition from the Malthusian regime to self-sustaining developed economies is education. Improved health is normally envisaged as simply a by-product of economic growth. Whereas growth does, indeed, tend to improve health status, the reverse is also true, namely that health improvements are a dynamic force capable of driving economic expansion. This paper underlines the importance of health improvements in escaping from Malthusian stagnation. Further, and in contrast to existing literature, which emphasizes the effects of changes in mortality rates, this paper focuses on the relationship between health status and the efficiency of human capital technology. Through this channel, health improvements stimulate investments in child quality in terms of both nourishing and schooling and drive the economy towards the Modern Growth regime.
Adjustment of L‐T4 substitutive therapy in pregnant women with subclinical, overt or post‐ablative hypothyroidism

Objective Maternal hyperthyrotropinaemia is associated with an increased risk of adverse maternal and neonatal outcomes. Physiological changes during pregnancy require an increased production of thyroid hormones (or an increase in daily substitutive doses of L‐T4 in hypothyroid patients) to meet the maternal and foetal needs. The aim of the study was to evaluate variations of substitutive L‐T4 doses that are able to maintain serum TSH between 0·5 and 2·5 mU/l in pregnant women with subclinical‐ (SH), overt‐ (OH) and post‐ablative (PH) hypothyroidism.
Essays on Inventory Control in Presence of Multiple Sourcing

The policy of simultaneously splitting replenishment orders among several suppliers has received considerable attention in the last few years and continues to attract the attention of researchers. In this paper, we develop a mathematical model which considers multiple-supplier single-item inventory systems. The item acquisition lead times of suppliers are random variables. Backorder is allowed and shortage cost is charged based on not only per unit in shortage but also per time unit. Continuous review (s, Q) policy has been assumed. When the inventory level depletes to a reorder level, the total order is split among n suppliers. Since the suppliers have different characteristics, the quantity ordered to different suppliers may be different. The problem is to determine the reorder level and quantity ordered to each supplier so that the expected total cost per time unit, including ordering cost, procurement cost, inventory holding cost, and shortage cost, is minimized. We also conduct extensive numerical experiments to show the advantages of our model compared with the models in the literature. According to our extensive experiments, the model developed in this paper is the best model in the literature which considers order splitting for n-supplier inventory systems since it is the nearest model to the real inventory system. ∗CORAL Centre for Operations Research Applications in Logistics, Department of Economics and Business, Aarhus School of Business and Social Sciences, Aarhus University, Fuglesangs Allé 4, Aarhus V, DK-8210, Denmark. †Centre for Maritime Studies, National University of Singapore, Singapore ‡Department of Industrial Engineering, Amirkabir University of Technology, Tehran, Iran Paper 1 16 2.
Public Debt and J.S. Mill’s Conjecture: A Note

Classical economists - mainly Smith, Ricardo and J.S. Mill - abhorred public debts because of their interference with capital accumulation. J.S. Mill in particular envisaged that a rising public debt leads to higher interest rates and falling real wages, a combination which may be consistent with a mildly increasing trend in the profit rate.
Extending Resource-Based Logic

This article argues that resource-based logic can be extended by conceptualizing the firm in resource-investment terms. It establishes that investing in resources is essentially a bilateral process involving managers and the owners of capital and that all resource-investments are necessarily made within an institutional superstructure. As a result, the capital invested into the firm is necessarily highly structured. These ideas are developed in this article from a payments perspective because this perspective allows scholars to explore the ex ante investment decisions that allow firms to grow, and to focus on firms’ resource payments, which can be considered a proxy for firms’ ex post resource-investments. The article concludes with a discussion of the implications of these ideas, including the implications for performance, theory of the firm, and endogenous growth research.
What are the factors that affect innovation in growing SMEs

Purpose – The purpose of this paper is to report on a study aimed at identifying factors that affect the innovativeness of growing small and medium‐sized firms (SMEs). It aims to use intellectual property rights (IPRs) as a proxy for innovations. The IPRs to be used include patents, trademarks, utility models and registered designs.Design/methodology/approach – A theoretical model was developed and tested on longitudinal sample data representing 348 continuously growing SMEs located in two diverse regions in Finland. The firms in the sample represented various industries. Logistic regression analysis was used to analyse the data.Findings – About 8 per cent of the firms in the sample could be defined as innovative growth SMEs. Most of these firms operate in the service and manufacturing sectors. They are small businesses that employ ten to 49 people and are between five and 19 years old. Innovative firms in this class were found to be less likely successful in the short‐term than their non‐innovative count.
Social Capital and Political Participation: Understanding the Dynamics of Young People's Political Disengagement in Contemporary Britain

Only 37 per cent of young people voted at the 2005 British General Election, seemingly confirming the oft-cited view that this generation is becoming increasingly disconnected from the political process. Results from a nationwide survey, however, indicate that their withdrawal from formal politics is more a result of their scepticism of the way the political system operates, than apathy. Furthermore, they are diverse in their political (dis)engagement. Results from an examination of the relative effects of socio-economic location and social capital are inconclusive, although the data indicate that government social policy aimed at mobilising social capital and addressing socio-economic issues may increase civic engagement.
Fundamental Analysis Future Earnings, and Stock Prices

This paper examines empirical relations between rules of fundamental analysis and actual future earnings changes, analysts' earnings forecast revisions, and contemporaneous stock returns. Our results indicate that many of the fundamental signals are related to future earnings and forecast revisions in the same way they are related to returns, however some significant exceptions are noted. Conditioning the relations on variables reflecting the macroeconomic, firm-specific and industry-specific contexts in which firms operate provides some further refinement to our understanding of the information contained in the fundamental signals. Additional tests suggest analysts' forecast revisions display generalized underreaction to the future earnings information contained in some of the fundamental signals.
Debiasing Audit Judgment With Accountability - A Framework And Experimental Results

This paper examines whether accountability, defined as the requirement to justify one's judgments to others, mitigates recency. Recency refers to the tendency to overweight evidence received later in a sequence. ' Ideally, judgments are influenced by the substance of evidence, not the order in which it is evaluated. Audit judgments may be prone to recency because auditing involves updating beliefs about financial statement assertions on the basis of new evidence. Indeed, audit judgment research documents recency in experiments with no explicit accountability requirements. These results have implications for audit efficiency and effectiveness if there are no mechanisms in the audit process to correct or mitigate these tendencies. One such mechanism is the
Smoothing, Nonsynchronous Appraisal and Cross-Sectional Aggregation in Real Estate Price Indices

In this article three econometric issues related to private-equity return indices, such as real estate indices, are explored (smoothing, nonsynchronous appraisal and cross-sectional aggregation). Under certain assumptions, it is found that index returns based on appraisals follow an ARFIMA(1, d, 1) (autoregressive fractionally integrated moving average) process, where the long memory parameter (d) explains the level of smoothing and the AR and MA parameters represent the level of persistence in marketwide fundamentals and the nonsynchronous appraisal, respectively. The empirical results show that: (1) the level of smoothing in appraisal-based real estate indices is far less than assumed in many academic studies (2) there is weak evidence of nonsynchronous appraisal in the UK, IPD (Investment Property Databank) index and (3) marketwide fundamentals are highly persistent for the IPD index returns. On the other hand, there is no evidence of nonsynchronous appraisal or a persistent common factor in the U.S. NCREIF (National Council of Real Estate Investment Fiduciaries) index.
10 05 4 v 2 21 N ov 2 00 6 Inflation without Inflaton ( s )

We propose a model for early universe cosmology without the need for fundamental scalar fields. Cosmic acceleration and phenomenologically viable reheating of the universe results from a series of energy transitions, where during each transition vacuum energy is converted to thermal radiation. We show that this ‘cascading universe’ can lead to successful generation of adiabatic density fluctuations and an observable gravity wave spectrum in some cases, where in the simplest case it reproduces a spectrum similar to slow-roll models of inflation. We also find the model provides a reasonable reheating temperature after inflation ends. This type of model can also be used to explain the smallness of the vacuum energy today.
Homeownership and Wealth among Low- and Moderate-Income Households

Using data from a set of low- and moderate-income homeowners who received prime mortgages through the Community Advantage Program panel and a matched set of renters, we assess the effect of sustained homeownership on net worth and components of net worth. In this article, our aim is to test the claim that, all else being equal, investing in and maintaining ownership of a home yield higher short-term increases in net worth and other measures of economic well-being than do renting and choosing other forms of investment and consumption. We attempt to isolate the effect of homeownership from the factors that cause both homeownership and increases in wealth using three matching approaches that address sample selection and endogeneity in the data. After balancing renters and owners on observed characteristics and adjusting for influential outlying cases, we find that low- and moderate-income homeowners experience greater short-run increases in net worth, assets, and nonhousing net worth than renters do. These findings are particularly interesting because the period of study coincides with the housing crisis, periods of shrinking home values, and declining equity in the housing market as a whole.
Life Cycle–based Assessment of Energy Use and Greenhouse Gas Emissions in Almond Production, Part II: Uncertainty Analysis through Sensitivity Analysis and Scenario Testing

This is the second part of a two‐article series examining California almond production. The part I article describes development of the analytical framework and life cycle–based model and presents typical energy use and greenhouse gas (GHG) emissions for California almonds. This part II article builds on this by exploring uncertainty in the life cycle model through sensitivity and scenario analysis, and by examining temporary carbon storage in the orchard.
Corporate entrepreneurship and innovation part 2: a role‐ and process‐based approach

Purpose – To extend the discussion held in part 1, and develop a two‐tier fifth‐generation model of corporate entrepreneurship and innovation.Design/methodology/approach – The components that have been synthesized from a review of the literature in Part 1 are extended using evidence from the literature. These components are used to construct a two‐tier model of corporate entrepreneurship and innovation; a macro model which presents the high‐level environmental drivers of innovation and a micro model that discusses the contextual factors that underpin the corporate entrepreneurship and innovation process.Findings – From the analysis conducted in part 1 it is evident that there is a strong relationship between the role of the corporate entrepreneur and the innovation process. It is suggested that by separating the corporate entrepreneur from the innovation process previous models have been overly reductionist in their construction, and their utility has, as a consequence, been severely constrained. The stud.
Camptocormia in Parkinson disease: an epidemiological and clinical study

Background: Camptocormia is an abnormal flexion of the thoracolumbar spine during standing and walking that abates in the recumbent position. Methods: In a single-centre epidemiological and clinical study, the prevalence of camptocormia in Parkinson disease (PD) and its relationship with the clinical features of PD were investigated. A total of 275 consecutive outpatients were systematically screened for camptocormia with a clinical evaluation. Patients who screened positive for camptocormia were subsequently reassessed by formal goniometric analysis. The demographic and clinical features of the patients with and without camptocormia were then compared. Results: A 6.9% (19/275, 95% CI, 4.2 to 10.6) prevalence of camptocormia was found. Camptocormia was found in patients with more severe PD, as clinically assessed by the Hoehn–Yahr (HY) staging and the motor Unified Parkinson Disease Rating Scale (UPDRS) part III, longer l-dopa treatment duration and greater l-dopa daily dose and presence of DSM-IV dementia. Camptocormia was reported to develop after the clinical onset of PD. No correlation was found between the degree of trunk flexion and age, duration of PD, UPDRS motor score, HY staging, and l-dopa treatment duration and dose. As a risk factor, the study identified previous vertebral surgery. Conclusions: Camptocormia, a relatively common sign in PD seems to be related to the clinical severity of PD.
Recreating residential property values in the inner city – an adapted ‘old’ institutional approach

This paper argues that old institutional economics (OIE) is well-placed to provide a conceptual framework for the analysis of issues surrounding property price developments. This is particularly true in arenas where qualitative factors cause a change that is discontinuous from the previous structure, such as amid urban regeneration. In this paper first the basic principles of OIE are outlined and a meta-theoretical position established. Then it is argued how this approach has potential applicability for explaining the house price impacts of decision making regarding urban regeneration. The study tests an OIE inspired typology of price and quality changes on processes of urban renewal within localised housing market areas. In doing so, empirical material is presented through two case studies: one from Amsterdam and the other from Budapest. Findings from these circumstances illustrate the value of an OIE approach for analysing house prices, quality elements and neighbourhood specific characteristics of urban regeneration. More generally, the study shows that OIE has plenty to offer for a ‘patchy’ and evolving problem area such as the analysis of urban property price development.
Determinants of Foreign Direct Investment

Despite the growing interest in capital and technology issues, certain issues still remain to be explored regarding the determinants of foreign direct investment by a multinational corporation and the corporation's consequent choice of investment location. This paper addresses some of these concerns by analyzing the determinants of foreign direct investment by a multinational corporation, both theoretically and empirically. For this purpose, the paper integrates a number of traditional and nontraditional variables into the standard theory of investment based on the maximization of the expected value of the firm. The theoretical model implies that both traditional as well as nontraditional factors matter in determining the flows of foreign direct investment in a country. The generalized investment theory on US foreign direct investment then is tested empirically utilizing panel data for 44 countries from 1983 to 1990. The estimation results provide considerable support for the importance of both traditional and nontraditional factors in determining flows of foreign direct investment in a country. Furthermore, the country-specific dummies show high level of significance, reflecting the importance of the country-specific characteristics in explaining flows of foreign direct investment. Copyright 2002 by Blackwell Publishing Ltd
Isolation and Sequence Characterization of Mammary Derived Growth Inhibitor Gene of Riverine Buffalo (Bubalus Bubalis)

In this study, attempts have been made to identify and characterize water buffalo (Bubalus bubalis) mammary derived growth inhibitor (MDGI) gene, isolated from a mammary gland cDNA library of lactating buffalo. The complete MDGI cDNA was of 698 nucleotides, consisting 61 nucleotides in 5′ UTR, coding region of 402 nucleotides, and 235 nucleotides representing the 3′ UTR. Comparison of nucleotide and deduced amino acid sequence data with that of MDGI//fatty acid binding protein (FABP) of other species shows three buffalo specific nucleotide changes while seven nucleotide changes were common to cattle and buffalo. Buffalo and cattle MDGI had 100% amino acid sequence similarity, which also shared three amino acid changes: 34 (Ala-Gly), 109 (Leu-Met), and 132 (Glu-Gln) as compared to other species. Comparison with FABPs reported from other cattle tissues revealed highest amino acid sequence similarity with FABP-heart (100%) and least with FABP-liver (20.5%). Phylogenetic analysis revealed cattle MDGI to be closest to buffalo, while mouse MDGI was distantly placed, whereas different tissue derived FABPs of cattle showed FABP-heart closest and FABP-epidermis most distantly placed from buffalo MDGI. This report also differs from the earlier findings that MDGI is intermediate of FABP-heart and adipose.
The Toyota Way model: an alternative framework for lean construction

As the success of lean production is widespread, both inside and outside the manufacturing industry, there have emerged a number of models of lean construction, which look into the possible implementation of the lean principles in the construction industry. While it is commonly accepted that lean production has its basis in the Toyota production system (TPS), the ‘Toyota Way’ has developed as something more than simply the TPS. This study examines the current implementation frameworks of lean construction and proposes an alternative framework for the construction industry based on the Toyota Way model. It is hoped that this ‘back to the basics’ approach can be used to bring greater clarity to lean construction by means of the Toyota Way model. The comprehensiveness of the Toyota Way model means that it can bring about multiple angles from which to look at the lean construction model for the construction industry.
Why is Stabilization Sometimes Delayed?

Existing work on the politics of stabilization has failed to find compelling evidence of a regime-type effect. This article reformulates and reevaluates the regime-type hypothesis. It is argued that regime type does not have an independent impact on the timing of stabilization. Instead, regime type influences the extent to which societal opposition and distributive conflict will delay stabilization. Societal opposition and distributive conflict are likely to delay stabilization in democratic regimes, because governments must worry about maintaining power. Such societal dynamics are less likely to delay stabilization in authoritarian regimes. Using a sample of 92 high-inflation episodes, precisely these regime-specific dynamics surrounding the politics of stabilization were found. Governments in democratic regimes want to stabilize rapidly but often cannot overcome societal opposition and distributive conflict to do so. Authoritarian regimes are substantially less constrained by societal opposition and distributive conflict but have less incentive to stabilize rapidly.
The Role of Networks In the Diffusion of Technological Innovation

This research considers the diffusion of computer-aided production management (CAPM) technology in the UK manufacturing sector during the mid to late 1980s, focusing on the role of inter-organizational networks in the diffusion process. Research on innovation diffusion has tended to adopt a 'pro-innovation bias' such that adoption of prescribed best practice technologies is always considered to be the best policy. In the UK, one particular form of CAPM (MRP/MRPII) has been heavily promoted by technology suppliers as best practice. However, the notion of 'best practice' de-emphasizes the importance of decisions about technology design when users attempt to develop firm-specific solutions. Crucial to these decisions are the inter-organizational networks through which potential adopters learn about relevant technologies. Using three case companies, where the introduction of CAPM occurred at approximately the same time, decisions regarding adoption, design and subsequent implementation, are explored in order to establish the influence of inter-organizational networks on the diffusion and subsequent appropriation of CAPM technologies. These cases revealed that potential adopters engaged in a range of inter-organizational networks through which they learned about new technologies. However, the knowledge diffused through many of these networks was shaped by technology suppliers who were promoting similar ideas about best practice. Thus, while involvement in inter-organizational networks gave potential adopters access to information about new technology, this information tended to reinforce supplier images of best practice and did not always lead these firms to develop appropriate technological solutions. Problematic relationships between the suppliers of the technology and the users was seen here to limit the redesign and further diffusion of CAPM. Copyright 1996 Basil Blackwell Ltd.