Miracle-dz/UniFAR-FTUs huggingface dataset:
Distribution of the SsuDAT1I Restriction-Modification System among Different Serotypes ofStreptococcus suis

ABSTRACT The SsuDAT1I restriction-modification (R-M) system, which contains two methyltransferases and two restriction endonucleases with recognition sequence 5′-GATC-3′, was first found in a field isolate of Streptococcus suis serotype 2. Isoschizomers of the R-M system were found in the same locus betweenpurH and purD in a field isolate of serotype 1/2 and the reference strains of serotypes 3, 7, 23, and 26 among 29 strains of different serotypes examined in this study. The R-M gene sequences in serotypes 1/2, 3, 7, and 23 were very similar to those of SsuDAT1I, whereas those in serotype 26 were less similar. These results indicate intraspecies recombination among them and genetic divergence through their evolution.
A modeling study of oceanic nitrous oxide during the Younger Dryas cold period

The marine production, cycling, and air‐sea gas exchange of nitrous oxide (N2O) are simulated in a coupled climate‐biogeochemical model of reduced complexity. The model gives a good representation of the large‐scale features of the observed oceanic N2O distribution and emissions to the atmosphere. The transient behavior of the model is tested for the Younger Dryas (Y‐D) cold period (12,700–11,550 BP), which is simulated by releasing a freshwater pulse into the North Atlantic, causing a temporary collapse of the model's Atlantic thermohaline circulation (THC). A temporary drop in atmospheric N2O of about 10 ppb results, while ice‐core measurements show a total drop of 25 to 30 ppb. This suggests that terrestrial changes have also contributed to the observed variations. The main cause of the modeled reduction in atmospheric N2O is increased oceanic storage in the short‐term and a reduction of new production in the long‐term due to increased stratification.
Pengaruh Kepemilikan Institusional Dan Kepemilikan Manajerial Pada Konservatisme Akuntansi

This study examines the effect of institutional ownership and managerial ownership on accounting conservatism. The institution as the majority shareholder of the company strives to present quality earnings because it realizes that earnings information is an important concern for investors in making investment decisions. In addition, management participation as the owner of the company will be able to align goals between shareholders and management. Profit ability to maintain its quality is often associated with accounting conservatism. The population of this study is a company going public on the Indonesia Stock Exchange in the non-financial sector in the period 2014 to 2017. The study sample was determined using a purposive sampling method which resulted in a sample of 364 observations. The data analysis technique used in the study is multiple linear regression analysis. The test results prove that institutional ownership and managerial ownership have a positive effect on accounting conservatism. Keywords: Accounting conservatism; Institutional ownership; Managerial ownership. Penelitian ini menguji pengaruh kepemilikan institusional dan kepemilikan manajerial pada konservatisme akuntansi. Institusi sebagai pemegang saham mayoritas perusahaan berusaha untuk menyajikan laba yang berkualitas karena menyadari bahwa informasi laba menjadi perhatian penting bagi investor dalam melakukan keputusan investasi. Disamping itu, penyertaan manajemen sebagai pemilik perusahaan akan mampu mensejajarkan tujuan antara pemegang saham dengan manajemen. Kemampuan laba dalam mempertahankan kualitasnya seringkali dikaitkan dengan konservatisme akuntansi. Populasi penelitian ini adalah perusahaan go public di Bursa Efek Indonesia yang berada pada sektor non finansial pada periode 2014 hingga 2017. Sampel penelitian ditentukan dengan menggunakan metode purposive sampling yang menghasilkan sampel penelitian sejumlah 364 observasi. Teknik analisis data yang digunakan dalam penelitian adalah analisis regresi linear berganda. Hasil pengujian membuktikan bahwa kepemilikan institusional dan kepemilikan manajerial berpengaruh positif pada konservatisme akuntansi. Kata kunci: Konservatisme akuntansi; Kepemilikan institusional; Kepemilikan manajerial.
A journey of hope: lessons learned from studies on rare diseases and orphan drugs

Rare diseases are frequently life‐threatening or chronically debilitating and the impact on the quality of life of affected patients and their family members is thus significant. However, drug development for these conditions has been limited by a lack of understanding of the underlying mechanisms of disease and the relative unavailability of subjects for clinical trials, as well as the prohibitive cost of investing in a novel pharmaceutical agent with poor market potential. Nevertheless, the introduction of Orphan Drug legislations has provided important incentives for the development of orphan drugs (i.e. drugs that have been abandoned or ‘orphaned’ by major drug companies). Moreover, recent studies on rare diseases, including inherited immunodeficiencies and metabolic disorders, have served not only to alleviate the plight of patients with rare diseases, but also yielded valuable information on biological processes of relevance for other, more common conditions. These lessons, along with the crucial importance of cooperation between academic institutions, pharmaceutical companies, patient advocacy groups and society in the elucidation of rare diseases, are highlighted in the present review.
Disruption of the Terrestrial Plant Ecosystem at the Cretaceous-Tertiary Boundary, Western Interior

The palynologically defined Cretaceous-Tertiary boundary in the western interior of North America occurs at the top of an iridium-rich clay layer. The boundary is characterized by the abrupt disappearance of certain pollen species, immediately followed by a pronounced, geologically brief change in the ratio of fern spores to angiosperm pollen. The occurrence of these changes at two widely separated sites implies continentwide disruption of the terrestrial ecosystem, probably caused by a major catastrophic event at the end of the period.
Cognitive appraisals and posttraumatic stress disorder symptoms in informal caregivers of stroke survivors.

OBJECTIVE To examine associations between cognitive appraisals (i.e., negative appraisals about the self, negative appraisals about the world, and self-blame) and the severity of posttraumatic stress disorder (PTSD) symptoms in informal caregivers (i.e., family relatives or close associates) of stroke survivors. METHOD A cross-sectional study was conducted in which informal caregivers (N = 51) of recent stroke survivors completed the Posttraumatic Diagnostic Scale and the Posttraumatic Cognitions Inventory. RESULTS PTSD symptom severity correlated significantly with the Posttraumatic Cognitions Inventory Self, World, and Self-Blame subscales and with time since stroke and age (negative relationship). Cognitive appraisals explained 58% of the variance in PTSD symptom severity. CONCLUSION The associations found between negative cognitive appraisals and the severity of PTSD symptoms are consistent with current cognitive models of PTSD and the recommended use of trauma-related cognitive-behavioral therapy for individuals with PTSD.
Efficent Use of Antioxidants to Preserve Fruit Juice

MIREL GLEVITZKY1*, MARIANA POP2, GABRIELA-ALINA BRUSTUREAN3, IOANA BOGDAN4, MIRELA CALISEVICI5, DELIA PERJU6 1Alba Sanitary-Veterinary and Food Safety Direction, 7A Lalelelor Str. , 510217, Alba Iulia, Romania 4 S.C. European Drinks S.A. , Department of Research, Development and Quality Control, Rieni, 417415, Bihor, Romania 2,3,5,6 Politehnica University of Timisoara, Faculty of Industrial Chemistry and Environmental Engineering, 2 Victoriei Square, 300006, Timisoara, Romania
Congruence between personal and organizational mission: The role of balanced organizational values

Organizational mission is starting point for all organizational activities and its definition is traditionally in the responsibility of the top management. However, more and more authors, but also examples from business practice, indicate that unilaterally definition of organizational mission by the top management does not give expected results, and especially if such defined mission is not aligned with personal missions of employees. The purpose of this paper is to highlight the importance of connection, and even the congruence between personal and organizational mission, with special emphasis on the key link of this connection – organizational values. In doing so, we considered the similarities and differences between personal and organizational mission and then we analyzed the benefits of integration of personal and organizational mission for modern organizations. Today's employees spend a lot of time at work and it is harder to separate private from business life. Given that fact, individuals whose personal mission is congruent with the organization's mission are more satisfied with their job. However, for congruence between personal and organizational mission, it is very important to create a culture based on well-institutionalized values. Based on the Mission-based model of organizational values and its four dimensions—stability, progress, self-orientation, and social-orientation—in this article we analyze how these different types of values can reinforce the connection between the personal mission of employees and the organizational mission. The role of balanced values in doing so is invaluable, because they are the "glue" that properly connects personal and organizational mission. Following these arguments, we provide recommendations for further research and practice on how to address the mission fit and alignment.
Examples of plane curves of low degrees with hyperbolic and C – hyperbolic complements

We find explicit examples of families of irreducible plane projective curves C ⊂ IP 2 of any even degree starting with degree six, such that the complement IP 2 \ C is C–hyperbolic. The latter means that some covering over IP 2 \C is Carathéodory hyperbolic. This implies that the complement IP 2 \ C is Kobayashi hyperbolic and (due to Lin’s Theorem) that the fundamental group π1(IP 2 \ C) does not contain a nilpotent subgroup of finite index.
Novel role of immature myeloid cells in formation of new lymphatic vessels associated with inflammation and tumors

Inflammation triggers an immune cell‐driven program committed to restoring homeostasis to injured tissue. Central to this process is vasculature restoration, which includes both blood and lymphatic networks. Generation of new vessels or remodeling of existing vessels are also important steps in metastasis—the major cause of death for cancer patients. Although roles of the lymphatic system in regulation of inflammation and cancer metastasis are firmly established, the mechanisms underlying the formation of new lymphatic vessels remain a subject of debate. Until recently, generation of new lymphatics in adults was thought to occur exclusively through sprouting of existing vessels without help from recruited progenitors. However, emerging findings from clinical and experimental studies show that lymphoendothelial progenitors, particularly those derived from immature myeloid cells, play an important role in this process. This review summarizes current evidence for the existence and significant roles of myeloid‐derived lymphatic endothelial cell progenitors (M‐LECPs) in generation of new lymphatics. We describe specific markers of M‐LECPs and discuss their biologic behavior in culture and in vivo, as well as currently known molecular mechanisms of myeloid‐lymphatic transition (MLT). We also discuss the implications of M‐LECPs for promoting adaptive immunity, as well as cancer metastasis. We conclude that improved mechanistic understanding of M‐LECP differentiation and its role in adult lymphangiogenesis may lead to new therapeutic approaches for correcting lymphatic insufficiency or excessive formation of lymphatic vessels in human disorders.
Learning objects: weapons of mass instruction

L'auteur debat des enjeux decoulant du developpement des nouveaux outils d'apprentissage reposant sur une utilisation des Nouvelles Technologies de l'Information et de la Communication, et sur les capacites d'adaptation de ces outils aux necessites et finalites de l'education.
Corporate Disclosure Quality and Institutional Investors' Holdings During Market Downturns

Abstract We examine institutional investors' responses to corporate disclosure quality conditional on market states. Transient institutions react more positively to corporate disclosure quality during market downturns than during normal market periods, as better disclosure practices lower information asymmetry and are thus associated with reduced uncertainty, enhanced liquidity, and weakened impacts of crises, which are the most desirable features of assets during market downturns. Dedicated institutions are insensitive to corporate disclosure quality in both normal and market downturn periods, as they have access to inside information and rely less on public disclosures. Their reliance on corporate disclosures in market downturns, however, increases sharply after the implementation of Regulation Fair Disclosure, which removes their inside information advantage. We further show that corporate disclosure reduces information asymmetry to a greater extent in market downturns than in normal market periods and that transient ownership in market downturns provides strong price support and stabilizes return volatility, whereas dedicated ownership does not possess such functions. Finally, we show that the results are not simply driven by endogeneity and are robust to alternative corporate disclosure quality measure and to the control of other determinants of institutional holdings.
In vitro mechanism of inhibition of bacterial cell growth by allicin

Diallyl thiosulfinate (allicin) is the agent found in garlic which is responsible for the antibacterial and antifungal activity of extracts of this plant. The effect of bacteriostatic concentrations of allicin (0.2 to 0.5 mM) on the growth of Salmonella typhimurium revealed a pattern of inhibition characterized by: (i) a lag of approximately 15 min between addition of allicin and onset of inhibition, (ii) a transitory inhibition phase whose duration was proportional to allicin concentration and inversely proportional to culture density, (iii) a resumed growth phase which showed a lower rate of growth than in uninhibited controls, and (iv) an entry into stationary phase at a lower culture density. Whereas DNA and protein syntheses showed a delayed and partial inhibition by allicin, inhibition of RNA synthesis was immediate and total, suggesting that this is the primary target of allicin action.
FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression*

CD4+ T-cells in systemic lupus erythematosus (SLE) patients show altered T-cell receptor signaling, which utilizes Fc-receptor γ-chain FcRγ-Syk. A role for FcγRIIIa activation from immune complex (IC) ligation and sublytic terminal complement complex (C5b-9) in CD4+ T-cell responses is not investigated. In this study, we show that the ICs present in SLE patients by ligating to FcγRIIIa on CD4+ T-cells phosphorylate Syk and provide a co-stimulatory signal to CD4+ T-cells in the absence of CD28 signal. This led to the development of pathogenic IL-17A+ and IFN-γhigh CD4+ T-cells in vitro. Cytokines IL-1β, IL-6, TGF-β1, and IL-23 were the only requirement for the development of both populations. SLE patients CD4+ T-cells that expressed CD25, CD69, and CD98 bound to ICs showed pSyk and produced IFN-γ and IL-17A. This FcγRIIIa-mediated co-signal differentially up-regulated the expression of IFN pathway genes compared with CD28 co-signal. FcγRIIIa-pSyk up-regulated several toll-like receptor genes as well as the HMGB1 and MyD88 gene transcripts. ICs co-localized with these toll-like receptor pathway proteins. These results suggest a role for the FcγRIIIa-pSyk signal in modulating adaptive immune responses.
Robot-assisted laparoscopic radical prostatectomy in the renal allograft transplant recipient.

BACKGROUND AND PURPOSE Since the advent of immunosuppressive therapy, patients have been able to lead longer lives as transplant recipients. We report the first case of robot-assisted laparoscopic prostatectomy in the renal allograft recipient. PATIENTS AND METHODS A 54-year-old man presented with Gleason 3+3 localized prostate cancer with a prostatespecific antigen level of 8.5 ng/mL. He had a history of end-stage renal failure secondary to fulminant acute pyelonephritis necessitating bilateral nephrectomy. Renal allograft transplant in the right iliac fossa was performed in 1981, with adequate renal function while continuing his immunosuppressant regime. The patient also had previous left inguinal herniorrhaphy. Modifications to our surgical approach include placement of a bariatric port superiolaterally to the standard port site; siting the left port inferiolaterally to provide adequate access for pelvic lymph node dissection; and developing the retropubic space largely from the contralateral side to avoid allograft injury. Extensive adhesiolysis was also needed. After negative urethral margin reported on frozen section, vesicourethral anastomosis was fashioned using our Cornell bladder neck anatomic reconstruction technique. RESULTS The patient needed a postoperative transfusion of 1 unit of blood and was discharged on postoperative day 2 after recommencement of immunosuppression. The final pathology report revealed pT(2c) Gleason 7 (3+4) disease and negative surgical margins. Continence was recovered within the first week of catheter removal, and erections sufficient for penetration occurred before 6-week follow-up in the clinic. CONCLUSION Robot-assisted radical prostatectomy is feasible in the carefully selected renal allograft recipient with favorable oncologic, continence, and potency outcomes.
Redetermination of MgCrO4·5H2O

The CCD-data based redetermination of the crystal structure of the title compound, magnesium chromate(VI) pentahydrate, confirms in principle the previous study based on precession film data [Bertrand et al. (1971 ▶). C. R. Hebd. Seances Acad. Sci. Serie C, 272, 530–533. ], but with all atoms refined with anisotropic displacement parameters and with all H atoms localized. This allowed an unambiguous assignment of the hydrogen-bonding pattern. MgCrO4·5H2O adopts the MgSO4·5H2O structure type. It contains two Mg2+ sites on special positions with site symmetry -1, one tetrahedral CrO4 group and five water molecules. Four of them coordinate to the Mg2+ cation, and one is an uncoordinating lattice water molecule. The octahedral environment of the Mg2+ cation is completed by two axial O atoms of CrO4 tetrahedra. This arrangement leads to the formation of chains parallel to [011]. Adjacent chains are linked through O—H⋯O hydrogen bonds (one of them bifurcated), involving both the coordinating and lattice water molecules, into a three-dimensional network.
Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios

The objective of this study was to assess both the anti-inflammatory and immunomodulatory effects of low-dosage simvastatin on rheumatoid arthritis (RA). In each patient, simvastatin at 10 mg/day was administered for 12 weeks. The other treatments were unchanged at least 3 months before simvastatin administration to the end of the study. Patients were assessed for the improvement in clinical, laboratory, and immunological parameters of RA and for adverse events. Twenty-four patients with RA were enrolled. Clinical symptoms, including patient's assessment of pain and disease activity on visual analog scale (VAS), the swollen joint and tender joint counts, and handgrip strength significantly improved. Physician's assessment of disease activity on VAS, a period of morning stiffness and modified health assessment questionnaire showed a tendency of improving after administration of low-dosage of simvastatin. Of special interest was that the median levels of erythrocytes sedimentation rate, C-reactive protein, and rheumatoid factor were significantly decreased from 54.0 mm/h to 45.5 mm/h, from 1.50 mg/dl to 0.85 mg/dl, and from 57.0 IU/ml to 28.0 IU/ml, respectively, after administration of simvastatin. ACR20 and ACR50 responses were achieved in 62% and 38%, respectively, of simvastatin-treated patients for 12 weeks. Immunological assessment in peripheral blood revealed that the Th1/Th2 and CD4/CD8 ratios were significantly reduced by simvastatin. No adverse events were reported during simvastatin treatment. Immunomodulation through the alteration of Th1/Th2 and CD4/CD8 ratios may be a pharmacological mechanism in the anti-rheumatic effect of low-dosage simvastatin. Although it is necessary to evaluate the long-term effects of statins, low-dosage statins appear to be good as additional therapeutic agents.
Galaxy Zoo: the dependence of the star formation–stellar mass relation on spiral disc morphology

We measure the stellar mass-star formation rate relation in star-forming disk galaxies at z 1. Of the galaxies lying significantly above the M-SFR relation in the local Universe, more than 50% are mergers. We interpret this as evidence that the spiral arms, which are imperfect reflections of the galaxy's current gravitational potential, are either fully independent of the various quenching mechanisms or are completely overwhelmed by the combination of outflows and feedback. The arrangement of the star formation can be changed, but the system as a whole regulates itself even in the presence of strong dynamical forcing.
Alternative Work Arrangements and Cost of Equity: Evidence from a Quasi-Natural Experiment

Abstract I examine whether firms’ use of alternative work arrangements, particularly temporary agency workers, affects their cost of equity. Exploiting a major labor-market deregulation in Japan that induced manufacturing firms to increase their employment of temporary agency workers, I show that the cost of equity decreased in manufacturing firms, relative to nonmanufacturing firms, after the deregulation. Further analysis using variations within manufacturing firms provides corroborating evidence. The rigidity in labor expenses and the cost of debt also decreased in manufacturing firms. Overall, alternative work arrangements increase the flexibility in labor costs, leading to lower operating leverage and cost of capital.
Disturbed Sleep in Patients Complaining of Chronic Pain

Polygraphic recordings of the sleep of patients complaining of insomnia has led to recognition of specific patterns of disturbed sleep corresponding to different etiologies of insomnia. This study presents results of polygraphic recordings of the sleep of 26 patients with chronic pain for which no physical cause can be found. All 26 also complained of insomnia. Sleep parameters of this group were compared with those of two other groups also complaining of insomnia: 12 patients whose disturbed sleep was judged secondary to psychiatric disorder, and 16 patients with the subjective complaint of insomnia in whom no objective evidence of sleep disturbance could be demonstrated. The three groups differed significantly in terms of their sleep parameters. The pain patients slept less than the subjective insomnia patients. The sleep disturbance of the psychiatric patients was more severe than that of the chronic pain patients. Several chronic pain patients showed evidence of nocturnal myoclonus; several also showed alpha rhythm intrusions into their sleeping electroencephalograms. The study verifies that chronic pain patients do experience significant sleep disturbance and raises several questions concerning relationships among chronic pain, sleep disturbance, and psychiatric illness, particularly depression.