Miracle-dz/UniFAR-FTUs huggingface dataset:
Practicability and acute haematological toxicity of 2- and 3-weekly CHOP and CHOEP chemotherapy for aggressive non-Hodgkin's lymphoma: results from the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL).

BACKGROUND There is evidence that intensified variants of the classical 3-weekly CHOP-21 chemotherapy [cyclophosphamide (C), doxorubicin (H), vincristine (O), prednisone (P)] may improve treatment outcome in aggressive lymphoma. Three variants using either an addition of etoposide (CHOEP-21: 100 mg/m(2) on days 1-3), the shortening to 2-week intervals using recombinant human granulocyte colony-stimulating factor (rhG-CSF; CHOP-14) or both (CHOEP-14) are currently compared with CHOP-21 in the NHL-B trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). To enable more extensive testing of these schemes we here characterise their practicability regarding schedule adherence, acute haematotoxicity and need for supportive treatment. PATIENTS AND METHODS The trial included patients with normal lactate dehydrogenase (LDH) aged </=60 years (NHL-B1) and patients aged 61-75 years (NHL-B2). The data are taken from an interim analysis. Data from 959 patients (CHOP-21: 232; CHOP-14: 238; CHOEP-21: 244; CHOEP-14: 245) from 162 institutions with a total of 5331 therapy cycles were evaluated. RESULTS The dose adherence in the NHL-B1 trial was excellent. The median relative dose (RD; i.e. actually given compared to planned dose) exceeds 98% for the myelosuppressive drugs in all four regimens. Only </=5% of patients received a relative dose <80% (RD <80). The median treatment duration could be shortened as scheduled for both CHOP-14 by 36 days and CHOEP-14 by 35 days. The dose adherence in the NHL-B2 trial was excellent for CHOP-21 and CHOP-14 for the myelosuppressive drugs (median RD >/=98%, RD <80 </=15%). Addition of etoposide, however, was accompanied by more dose erosion (median RD >/=97%, RD <80 </=17% for CHOEP-21 and </=27% for CHOEP-14). The median treatment duration could be shortened by 34 days with CHOP-14 compared with CHOP-21. Less treatment shortening was feasible for CHOEP-14 compared with CHOP-21 (median of 29 days). CHOP-14 and CHOP-21 were similar regarding toxicity profile, rate of infection, use of antibiotics, rate of transfusions and hospitalisation. CHOEP schemes were associated with a higher rate of infections, more transfusion requirements, more antibiotic use and longer hospitalisation than the CHOP schemes, particularly in patients aged >60 years. Haematopoietic recovery was age- and treatment-related. CONCLUSIONS CHOP-14 with the addition of rhG-CSF is safe and practicable in a large multicentre setting in patients aged 18-75 years. Despite shorter treatment intervals it can be delivered at the same dose as the classical 3-weekly CHOP with a comparable toxicity profile. The addition of etoposide is feasible and safe for patients </=60 years old in both the CHOEP-21 and CHOEP-14 schemes. For patients >60 years of age the addition of etoposide is associated with marked dose erosion due to increased toxicity. In this age group CHOEP should be used with caution.
Guess-Work and Reasonings on Centennial Evolution of Surface Air Temperature in Russia. Part II: Is it Possible to Research Both Local Peculiarities and Regional Tendencies from the Bifurcation Analysis Viewpoint?

This paper is devoted to the development of the experimental bifurcation analysis in the research of local climate dynamics. In particular, we consider the dynamics of the land surface air temperature in the centennial timescale. The experimental bifurcation analysis supposes the choice of a conceptual model to demonstrate how the observable kinds of dynamical processes can be realized on the whole. We worked on the conceptual model with a variable structure (HDS-model), where the dynamics is determined by the competition between the amplitude quantization and the time quantization. The model originates from the hysteresis regulator with double synchronization (HDS-regulator) proposed in 1970’s to achieve the extreme combination of both efficiency and reliability of energy conversion processes. The HDS-model allows to consider the interplay between several periodical processes instead of chaos and quasi-periodicity in order to excuse the variety of the behaviors observed in the local climate dynamics. In .
A New IBR Approach Based on View Synthesis for Virtual Environment Rendering

A general IBR (image based rendering) approach schema for synthesis image of new viewpoint is presented in this paper. Giving a series of images of an environment on closely spaced two circles viewpoints the proposed algorithm can generate perspective intermediate images of the environment in any viewpoint between two circles. In this case the same environment is displayed from the view of a virtual camera controlled by the user. The synthesis processing consists of three steps: First, the ring-like region between outer and inner circles can be divided as a set of fan-like sub-regions. Find the fan-like region to encircle the specified viewpoint; then an IBR processing between two images taken by moving camera along optical axis is implemented to generate two intermediate image; finally, an IBR processing between two images taken by moving camera around the scene is implemented to generate the destination image corresponding the specified viewpoint. Some experiment result images are also shown in this paper.
MEDULLARY PATHWAYS OF CARDIOVASCULAR RESPONSES TO 5‐HT2 AND 5‐HT3 RECEPTOR STIMULATION IN THE RAT NUCLEUS TRACTUS SOLITARIUS

As previously found for the baroreceptor reflex, microinjection of kynurenic acid (KYN, 2 nmol), a glutamate receptor antagonist, into the caudal ventrolateral medulla (CVL) blocked the hypotension and bradycardia elicited by microinjections of a 5-HT2 receptor agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI, 0.5 pmol) into the nucleus tractus solitarius (NTS). In addition, as previously observed with the sympathetic chemoreflex response, microinjections of KYN into the RVI, blocked the increase in blood pressure elicited by microinjections of 1-m-(chlorophenyl)-biguanide (1200 pmol), a 5-HT1 receptor agonist, into the NTS. These results suggest that medullary pathways involved in the responses to 5-HT2 and 5-HT3 receptor stimulation in the NTS are similar to those that mediate the baroceptor and chemoreceptor reflex responses, respectively.
Drugs Five Years Later: Trimethoprim-Sulfamethoxazole in the United States

: After approximately 5 years of clinical use in Great Britain and other European countries, trimethoprim-sulfamethoxazole in fixed-dose combination was introduced into the United States in 1973. As a result of sequential blockade in the biosynthesis of tetrahydrofolic acid, the antimicrobial activity of the combination exceeds that of either agent alone. Although the drug is approved for use in only chronic urinary-tract infection, otitis media, shigellosis, and Pneumocystis carinii pneumonia, many experimental clinical trials suggest that this agent may be useful in a number of other infectious disorders. Trimethoprim-sulfamethoxazole is generally well tolerated even with long-term administration, but its potential for hematologic toxicity and nephrotoxicity must be monitored.
Immunological cross-reactivity of anionic proteins from caries-free and caries-active salivas which differ in biological properties toward oral streptococci

We examined whether the anionic antimicrobial proteins in the saliva of certain caries-free (CF) individuals are immunologically cross-reactive with proteins in caries-active (CA) saliva which display identical isoelectric points but which exhibit growth-supportive properties for the oral streptococci. In the immunoblotting experiments reported here, the proteins present in CF and CA whole salivas reacted similarly with an antiserum prepared against the anionic inhibitory proteins. This antiserum also showed identical reactivity with the purified protein fraction containing the anionic proteins of interest from whole saliva of either CF or CA subjects. Additionally, an antiserum to CA saliva was found to react with the CF anionic inhibitory proteins. The fact that the inhibitory and noninhibitory proteins react similarly with the antisera used provides further evidence for similarity between both classes of proteins.
Journal of Enterprise Information Management Master data management and its organizational implementation : An ethnographical study within the public sector

Purpose – Master data management (MDM) aims to improve the value of an organization’s most important data, such as customer data, by bridging the silos between organizational units and information systems. However, incorporating data management practices into an organization is not a simple task. The purpose of this paper is to provide a new understanding of the challenges in establishing and developing the MDM function within an organization. Design/methodology/approach – This papers report an ethnographic study within a municipality. The data were collected from two consecutive MDM development projects over the time period of 32 months by observing MDM-related activities and interviewing appropriate actors. Observations, interviews, and impressions were documented to a diary that was later qualitatively analyzed. Various project documentation were also used. Findings – In total 15 challenges were identified. Seven of these were not identified earlier in the literature. New challenges included legislation-driven challenges, mutual understanding of master data domains, and the level of granularity for those domains. Eight issues, such as data owner and data definitions, were MDM specific, others being more generic. All of the issues were identified as preconditions or as affecting factors for the others. Three of the issues were identified as pivotal. The issues emphasize strong alignment between the complex concept of MDM and the organization adopting it. Research limitations/implications – This research was based on a single qualitative case study, and caution should be exercised with regard to generalizations. The findings increase understanding about the complex organizational phenomena. The study offers public sector and private sector practitioners insights of the organizational issues that establishing a MDM function can encounter. Originality/value – The issues discovered in the research shed light on the strong alignment between the complex concept of MDM and the organization. The results of this study assist researchers in their endeavor to understand the organizational aspects of MDM, and to build theoretical models, frameworks, practices, and explanations.
Low dietary intake altered the serum biochemical profile of cross breed heifers eliciting irregular estrous cycle

In Bangladesh, under feeding or over feeding is one of the major concerns to overcome the reproductive difficulties(anestrus) of cattle. The information on standard feeding using available local feed ingredients could be helpful to overcome the problem.Thestudy was conductedto determine the influence of dietaryintake on serum biochemical profile which prompts the estrous induction of cross breed heifers. A total of 12 of cross bred heifers were randomly selected bearing same age and body weight which weredivided into three uniform groups namelyT0 (Control or standard feeding), T1 (40% restricted or less feeding) and T2 (60% restricted feeding)were fed green grasses, concentrate and adlibitum water after frequentdeworming. The blood samples were collected aseptically from jugular veins every 15 days intervals of post treatment. The blood sera were used to analyze the biochemical profile using available commercial kits with standard methods. The animals of T1 and T2groupswerefoundsignificantly (p<0.01and/or p<0.05)lowglucose, total protein, calcium and iron values. On the other hand,sera phosphorus, manganese and cobalt level were found significantly (p<0.05) decrease in the animals of T2. In addition, no significant changes were found in serum zinc and copper values. Theheifersof T0exhibited regular estrous whereasthe heifers of T1 and T2 showedirregular estrus signs followed by anestrus. In thisstudy, it is revealed that standard feeding is very important tomaintaintheblood biochemical profile and estrus induction in heifers.
The Contingent Effect of Justice on Foci Commitment for Teachers of Public Universities: An Empirical Test of the Moderating Role of Trust

In public university setting, whether trust in supervisor would attenuate the relationship justice and commitment is not certain. In addition, past commitment research focused on organizational commitment, but neglected the foci of commitment. This study investigated the moderating role of trust in supervisor in the relation of distributive justice, procedural justice, and interactional justice with foci commitment (commitment to school, commitment to supervisor, and commitment to colleagues). It was expected that the relationships between three types of justice and foci commitment were weaker for those with high trust in their supervisor. This study uses teachers in public universities as the research sample, collects data by questionnaire survey, and analyzes data through hierarchical moderator regression. This study finds that whether trust in supervisor has the attenuating effect for the influence of justice on commitment depends on the type of justice and commitment. Trust in supervisor can attenuate all relationships between three types of justice and commitment to supervisor. However, regarding commitment to colleagues, trust in supervisor can only attenuate the effect of distributive justice on it.
Security Classification Using Automated Learning (SCALE): Optimizing Statistical Natural Language Processing Techniques to Assign Security Labels to Unstructured Text

Abstract : Automating the process of assigning security classifications to unstructured text would facilitate a transition to a data-centric architecture-one that promotes information sharing, in which all data in an organization are electronically labelled. In this document, we report the results of a series of experiments conducted to investigate the effectiveness of using statistical natural language processing and machine learning techniques to automatically assign security classifications to documents. We present guidelines for selecting parameters to maximize the accuracy of a machine learning algorithm's classification decisions for several well-defined collections of documents. We examine the significance of a document's topic and the effect of security policy changes on the ability of our system to automate classification; we include design recommendations to address both topic and policy considerations. Our classification techniques prove effective at assessing a document's sensitivity, achieving accuracies upwards of 80%.
Dapsone therapy for Henoch-Schonlein purpura.

We read with interest the article “Dapsone therapy for Henoch-Schonlein purpura: a case series” by Iqbal and Evans.1 They reported the clinical course of eight children with Henoch-Schonlein purpura (HSP) treated with dapsone due to the severity or persistence of their symptoms. All gained clinical response from treatment, but six relapsed after …
Radiation-induced breakdown in 1.7 nm oxynitrided gate oxides

We present new experimental data about the radiation-induced breakdown in 1.7 nm gate oxides, typical of the 90nm technology node. We irradiated several MOS capacitors with n- and p-type substrates and different areas under a positive and negative staircase bias with Ag ions. A modified testing procedure was introduced based on a low voltage sensing of the gate current during irradiation. We showed that, even in spite of a smaller gate oxide field, irradiation was more damaging for biases in deep depletion than for biases in accumulation. We attributed this to the injection in the oxide of energetic carriers heated in the depletion region. In this regime of operation, we highlighted the differences in the gate current degradation of nMOS and pMOS devices: abrupt changes followed by a smooth growth in the first ones, an increase proportional to the area in the second.
Association of DRD4 and COMT Polymorphisms with Disgust Sensitivity in Healthy Volunteers

Background: Disgust is a basic emotion that involves feelings of revulsion and withdrawal behavior from dangerous/infectious situations. Very little is known about the genetic basis of disgust sensitivity. The dopamine receptor D4 (DRD4) and catechol-O-methyltransferase (COMT) genes have been implicated in neuroticism-related traits and approach-related temperaments which are supposed to be associated with disgust sensitivity. The present study aimed to investigate the possible relationship between disgust sensitivity and COMT Val158Met and DRD4 variable number of tandem repeats (VNTR) polymorphisms in healthy subjects. Methods: In total, 241 healthy Korean college students were recruited, and the 228 participants with a complete data set (127 males and 101 females) were included in the data analysis. Disgust sensitivity was assessed using the Disgust Scale-Revised (DS-R) and genotyping of COMT Val158Met and DRD4 VNTR polymorphisms was performed. Results:The Val/Val groups of COMT had significantly higher scores than the non-Val/Val group for the Animal-Reminder and the Contamination-Based Disgust scores as well as for total DS-R scores. Additionally, the non-2-repeat allele group of DRD4 had a tendency to a significantly higher disgust sensitivity than the 2-repeat allele group for Contamination-Based Disgust. Conclusions: These findings suggest that disgust sensitivity may be affected by genetic components, such as dopamine-related genes.
Relationship between Transport of Bacteria and Their Clogging Efficiency in Sand Columns

In an earlier article, we reported that, under conditions in which neither exopolymers nor bacterial mats were produced, Arthrobacter sp. strain AK19 was an effective plugging agent in sand columns, whereas the bacterial strain SLI- had no significant effect on the permeability of the medium. A laboratory experiment with sand columns was carried out to elucidate the causes of this difference in behavior. Measured values of the saturated hydraulic conductivity of the sand were explained in terms of biomass accumulation, which was estimated by solving a mass balance equation. The relationship between the saturated hydraulic conductivity and the biomass density within the sand was exponential, although two different exponential coefficients were needed to fit the data for biomass densities above or below 13 mg (wet weight) per cm3, suggesting that two different clogging mechanisms may be involved in different ranges of biomass densities. The experimental results suggest that the SLI- strain was a poor clogging agent partly because of its lower yield coefficient relative to the limiting nutrient (oxygen) and partly because 60% of the biomass produced in situ was washed out from the column, compared with only 1.2% in the case of Arthrobacter sp. strain AK19.
Results and mid-long-term follow-up of stent implantation for native and recurrent coarctation of the aorta.

AIMS Since the late 1980s, endovascular stents have been used in the treatment of several vascular lesions. In the last decades, stent implantation has been proposed as a reliable option for the treatment of coarctation of the aorta. In this setting, it seems to have some advantages, rendering it superior to angioplasty alone. METHODS AND RESULTS Between December 1997 and December 2004, 71 consecutive patients (44 males and 27 females) underwent cardiac catheterization for native or recurrent coarctation of the aorta. Seventy-four stents were implanted. All discharged patients were enrolled in a follow-up programme. Every patient underwent clinical evaluation, echo-colour Doppler studies, and exercise ECG at 1 and 6 months after the stent implantation. Peak systolic gradient dropped from 39.3 +/- 15.3 to 3.6 +/- 5.5 mmHg (P = 0.0041). The diameter of the coarcted segment increased from 8.3 +/- 2.9 to 16.4 +/- 3.8 mm (P = 0.037). In our series, one death occurred in a 22-year-old girl with a recurrent coarctation of the aorta, just after stent implantation. The rate of minor complications was <2%. Re-dilatation of a previously implanted stent was performed in three patients. CONCLUSION In our experience (the largest reported to the best of our knowledge), stenting of a coarctation/re-coarctation of the aorta represents a safe alternative treatment without a significant mid-long-term complication.
Changes in Pattern of Heat Loss at High Ambient Temperature Caused by Water Deprivation in a Large Flightless Bird, the Emu

When exposed to high ambient temperatures, birds defend body temperature by increasing evaporative water loss, via either respiratory or cutaneous water loss. Water deprivation can lead to changes in thermal responses and lower levels of water use for thermoregulation. We have studied the effect of 2–3 wk of water deprivation on the physiological responses of emus during exposure to an ambient temperature of 45°C. Water deprivation led to a delay in the onset of panting (54 vs. 24 min after start of exposure) and to higher body temperatures (38.7° vs. 38.3°C) at the end of exposure to 45°C. After panting was initiated and body temperature stabilised, the water‐deprived emus had a lower total evaporative water loss (77 vs. 101 g/h), the same respiratory water loss (70 vs. 72 g/h), and a lower cutaneous water loss (7 vs. 29 g/h) than they did when hydrated. The factor contributing most to the lower total evaporative water loss in the dehydrated emus was a 47% reduction in dry thermal conductance, which led to a decrease in the exogenous environmental heat load and therefore the level of evaporation needed to defend body temperature. We suggest that the decrease in dry thermal conductance follows from the lower level of cutaneous water loss.
EFFECTS OF SALT RESTRICTION, SPIRONOLACTONE, AND AMMONIUM CHLORIDE ON ACID-BASE RELATIONS IN A CASE OF PRIMARY ALDOSTERONISM.

The following studies were carried out in a case of primary aldosteronism on the diet containing 10 g of NaCl and 3 g of K per day. NaCl restriction for 9 days resulted in a marked decrease of K excretion. The CI excretion also decreased in the same manner as the Na. Despite these urinary changes, the plasma K, Cl, and CO, levels were essentially unchanged. On spironolactone administration, on the other hand, plasma C02 fell, and K and Cl were elevated significantly, while there were a decrease of K excretion and a relative gain of Cl in excess of Na. A reduction of the urine pH was not demonstrated immediately after the beginning of spironolactone administration; acidification of the urine was gradually induced as the plasma CO,, lowered. After cessation of spironolactone, the Cl excretion became higher than the Na, accompanying further acidification of the urine. Although the increment of the H+ excretion in the case of ammonium chloride loading was entirely within the normal range, the Cl excretion did not increase at least during the first 2 days. The urinary acidification at night was shown in all the presented conditions. On the basis of these findings, it is suggested that Cl is a critical factor govern ing the development and correction of metabolic alkalosis in primary aldo steronism. In addition, it is reasonable to presume that the alkaline urine in