Miracle-dz/UniFAR-FTUs huggingface dataset:
The PHLAME firefighters' study: feasibility and findings.

OBJECTIVE To assess efficacy of 2 worksite health promotion interventions. METHODS Randomly assign 3 fire stations to (a) team-based curriculum, (b) individual counselor meetings, and (c) control. RESULTS Both interventions were feasible and acceptable, and they resulted in significant reductions in LDL cholesterol. The team approach significantly increased coworker cohesion, personal exercise habits, and coworkers' healthy behaviors. The one-on-one strategy significantly increased dietary self-monitoring, decreased fat intake, and reduced depressed feelings. CONCLUSIONS Although both interventions promoted healthy behaviors, specific outcomes differed and reflected their conceptual underpinnings. The team-based curriculum is innovative and may enlist influences not accessed with individual formats.
Nerve Growth Factor Is Mitogenic for Cancerous but Not Normal Human Breast Epithelial Cells*

We show here that nerve growth factor (NGF), the archetypal neurotrophic factor, is able to stimulate the proliferation of breast cancer cells (MCF-7 and MDA-MB-231 cell lines), although it is unable to stimulate growth of normal breast epithelial cells (NBEC). This stimulation induced cells in the G0 phase to reenter the cell cycle, as well as shortening cell cycle duration. Immunoblotting experiments revealed that both the two cancer cell lines and the NBEC express high affinity (p140 trk ) and low affinity (p75) NGF receptors. Inhibition of the NGF growth-promoting effect by the drugs K-252a and PD98059 indicated that activation of Trk-tyrosine kinase activity and the mitogen-activated protein kinase cascade are necessary to obtain the mitogenic effect. Activation of mitogen-activated protein kinase can be detected in breast cancer cells after 10 min of NGF stimulation, whereas no change was detected in NBEC. These results demonstrate that NGF is a mitogenic factor for human breast cancer cells and that it might constitute a new regulator of breast tumor growth.
Explicit Dehn filling and Heegaard splittings

We prove an explicit, quantitative criterion that ensures the Heegaard surfaces in Dehn fillings behave "as expected. " Given a cusped hyperbolic manifold X, and a Dehn filling whose meridian and longitude curves are longer than 2pi(2g-1), we show that every genus g Heegaard splitting of the filled manifold is isotopic to a splitting of the original manifold X. The analogous statement holds for fillings of multiple boundary tori. This gives an effective version of a theorem of Moriah-Rubinstein and Rieck-Sedgwick.
Spectrum and Outcome of Blunt Trauma Abdomen at Sardar Patel Medical College and PBM & Associate Group of Hospitals Dr

Blunt abdominal trauma is one of the important components of poly-trauma. It requires suspicion, investigation and proper management in time, to avoid morbidity & mortality. AIM: The aim of this prospective study spanning 1 year w.e. f. Jan, 2016 to December, 2016 in this tertiary care institute of SP Medical College & Hospital, Bikaner was to find out BTA patients in RTA, fall from height, and assault like injuries. We studied type of injuries, male-female ratio, age group& their operative & non-operative management. The study is based on 60 cases of BTA; managed in this institute from admission, investigation, management & possible follow up. Observations are depicted in different tables. Liver is most commonly involved solid organ followed by spleen, kidney & pancreas respectively. Initially solid organ injuries cases where treated by surgery, but than non-operative management are tried in haemostatically stable patients. Hollow visceral injuries were always managed by laparotomy & repair or resection as and when needed. Mortality occurred in 3 patients out 60 patients because of delay to reach hospital or septicemia, renal failure and shock due to multi organ failure. Close supervision with sophisticated infrastructure and quick action significantly reduces mortality.
Cognitive behaviour therapy for the treatment of depression in individuals with brain injury

This article focuses on depression and its psychological management following brain injury or stroke in the adult population. The presentation of depression in the context of brain injury is discussed and a summary of the psychosocial aetiological factors for the development of depression in this context is provided. The links between depression and neuropsychological functioning are explored and the significant impact of depression on neurorehabilitation outcome highlights the need for the development of effective interventions in this area. Cognitive behaviour therapy (CBT) is presented as a potentially suitable treatment: The model is described with ideas for the clinician on how to adapt the delivery of CBT for clients with neuropsychological impairment. To date, there have been a very small number of studies evaluating CBT for the treatment of depression in brain injury, however their results have been promising. It is concluded that further research is necessary.
Parent-of-origin effect and risk for attention-deficit/hyperactivity disorder: balancing the evidence against bias and chance findings.

To the Editor: In the December 2005 issue of The American Journal of Human Genetics, Hawi et al. made the intriguing observation that a group of catecholamine-related genes, shown elsewhere1 to be associated with attention-deficit/hyperactivity disorder (ADHD [MIM 143465]), further demonstrate a “consistent pattern of preferential paternal transmission of risk alleles to affected children with ADHD. ”2(p.959) The hallmark of this article is that it collated transmission/disequilibrium information from several genes and tested a combined genetic hypothesis, which led to the identification of remarkably significant statistical effects.
A study of police operated dispatch to acute coronary syndrome cases arising from 112 emergency calls in Aarhus county, Denmark

Background: The accuracy of the Danish police operated "112" emergency call system was studied. Dispatch of the anaesthesiologist staffed mobile emergency care unit (MECU) to acute coronary syndrome (ACS) cases was used as an indicator of accuracy of dispatch to life threatening emergencies. Methods: This was an observational cohort study of patients given a 112 system report of heart attack and patients with a provisional diagnosis of ACS made on scene by the MECU. Sensitivity, specificity, and positive predictive value with 95% confidence intervals (CI) were calculated. Results: There were 341 reports of “heart attack” and 205 patients with ACS. Sensitivity was 75% (95% CI 68% to 80%) specificity 90% (89% to 92%) and positive predictive value 45% (40% to 50%). Conclusion: The accuracy of 112 dispatch of the MECU was found to be moderate. We suggest more training of dispatch staff and medical supervision.
Unlearning as a driver of sustainable change and innovation: three Australian case studies

In building an organisation's innovation capacity, managers have to be aware of barriers to learning and have an understanding of the importance of unlearning old ways. Unlearning is emerging as an important element of change and innovation in organisations. As the pace of change continues to increase, it is clear that normal processes of forgetting and transition may not be sufficient. Two key scholars in this field have proposed models of unlearning however, little empirical research exists to further understanding of unlearning and the factors that may impact upon it. This paper reports on case study research aimed at further developing the concept of unlearning. A process model has emerged from the data that highlights inhibitors and enablers of the unlearning process. In an applied sense, the model provides managers with identifiable enablers and inhibitors of individual unlearning; issues which must then be addressed in change strategies at the organisational level.
Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes.

Leaves of tobacco (Nicotiana tabacum) are covered with glandular trichomes that produce sucrose esters and diterpenoids in varying quantities, depending on cultivar type. The bicyclic diterpene Z-abienol is the major labdanoid present in some oriental tobacco cultivars, where it constitutes a precursor of important flavours and aromas. We describe here the identification and characterization of two genes governing the biosynthesis of Z-abienol in N. tabacum. As for other angiosperm labdanoid diterpenes, the biosynthesis of Z-abienol proceeds in two steps. NtCPS2 encodes a class-II terpene synthase that synthesizes 8-hydroxy-copalyl diphosphate, and NtABS encodes a kaurene synthase-like (KSL) protein that uses 8-hydroxy-copalyl diphosphate to produce Z-abienol. Phylogenetic analysis indicates that NtABS belongs to a distinct clade of KSL proteins that comprises the recently identified tomato (Solanum habrochaites) santalene and bergamotene synthase. RT-PCR results show that both genes are preferentially expressed in trichomes. Moreover, microscopy of NtCPS2 promoter-GUS fusion transgenics demonstrated a high specificity of expression to trichome glandular cells. Ectopic expression of both genes, but not of either one alone, driven by a trichome-specific promoter in transgenic Nicotiana sylvestris conferred Z-abienol formation to this species, which does not normally produce it. Furthermore, sequence analysis of over 100 tobacco cultivars revealed polymorphisms in NtCPS2 that lead to a prematurely truncated protein in cultivars lacking Z-abienol, thus establishing NtCPS2 as a major gene controlling Z-abienol biosynthesis in tobacco. These results offer new perspectives for tobacco breeding and the metabolic engineering of labdanoid diterpenes, as well as for structure-function relationship studies of terpene synthases.
Correlates of institutional deliveries among teenage and non-teenage mothers in Nepal

Introduction Globally, maternal age is identified as an important predictor of institutional service utilization during delivery. This study aims to assess the correlates of institutional delivery among teenage and non-teenage mothers in Nepal by using the data from Nepal Demographic and Health Survey 2011. Methods The study population consisted of 5391 women of reproductive age (15–49 years) who had given birth to a child within five years before the survey. Out of them, 381 (7.07%) were teenage mothers. The association between the background characteristics and institutional delivery was assessed separately for the teenage and non-teenage mothers using chi-square test and multiple logistic regression analysis. Results After adjusting for background characteristics, teenage mothers were found more likely to deliver at a health facility [AOR: 2.25; 95% CI: 1.10 4.59] in comparison to the non-teenage mothers. Place of residence, occupation, socioeconomic status, and frequency of ANC visits were associated with institutional delivery in both the teenage and non-teenage mothers. However, educational status, parity, birth preparedness and women autonomy had statistically significant association with institutional delivery among the non-teenage mothers only. None of the background characteristics were significantly associated with institutional delivery in teenage mothers only. Conclusions This study identified a significant difference in institutional delivery service utilization among the teenage and non-teenage mothers. While the association of most of the background characteristics with institutional delivery was uniform for both teenage and non-teenage mothers, the association with educational status, parity, birth preparedness and women autonomy was significant only for non-teenage mothers. Considering this difference in the interaction of women’s background characteristics with institutional delivery between teenage and non-teenage mothers might help in identifying the pain points and devise targeted interventions to encourage institutional delivery in teenage mothers or non-teenage mothers or both.
Protein Fold Classification Using Large Margin Combination of Distance Metrics

SUMMARY Many methods have been proposed for measuring the structural similarity between two protein folds. However, it is di ﬃ cult to select one best method from them for the classiﬁcation task, as each method has its own strength and weakness. Intuitively, combining multiple meth-ods is one solution to get the optimal classiﬁcation results. In this paper, by generalizing the concept of the large margin nearest neighbor (LMNN), a method for combining multiple distance metrics from di ﬀ erent types of protein structure comparison methods for protein fold classiﬁcation task is proposed. While LMNN is limited to Mahalanobis-based distance metric learning from a set of feature vectors of training data, the proposed method learns an optimal combination of metrics from a set of distance metrics by minimizing the distances between intra-class data and enlarging the distances of di ﬀ erent classes’ data. The main advantage of the proposed method is the capability in ﬁnding an optimal weight coe ﬃ cient for combination of many metrics, possibly including poor metrics, avoiding the di ﬃ culties in selecting which metrics to be included for the combination. The e ﬀ ectiveness of the proposed method is demonstrated on classiﬁcation experiments using two public protein datasets, namely, Ding Dubchak dataset and ENZYMES dataset.
Brain Signatures of Syntactic and Semantic Processes during Children's Language Development

Developmental aspects of language comprehension were investigated using event-related brain potentials. Children between the ages of 6 and 13 listened to passive sentences that were correct, semantically incorrect, or syntactically incorrect, and data in each condition were compared with those of adults. For semantic violations, adults demonstrated a negativity (N400), as did children, but the latency decreased with age. For syntactic violations, adults displayed an early left anterior negativity (ELAN) and a late centro-parietal positivity (P600). A syntactic negativity and a late positivity were also present for children between 7 and 13 years, again with latency decreasing with age. Six-year-olds, in contrast, did not demonstrate an ELAN effect, but a late, reduced P600 pattern for the syntactic violation condition. In the early time window, the 6-year-olds displayed a widely distributed negativity that was larger for the correct than for the syntactically incorrect condition. These data indicate that the neurophysiological basis for semantic processes during auditory sentence comprehension does not change dramatically between early childhood and adulthood. Syntactic processes for passive sentences appear to differ between early and late childhood, at least with respect to those processes reflected in the ELAN component. As there is evidence that the ELAN reflects highly automatic structure building processes, we conclude that these processes are not yet established at age 7, but gradually develop toward adult-like processing during late childhood.
Positive affect and mood management in successful smoking cessation.

OBJECTIVE To examine the influence of positive affect and mood-management in the completion and success of an Internet-based smoking cessation intervention. METHODS Participants were recruited online (n = 1000) and randomized to 4 different interventions. Half of the participants received a mood-management tool. RESULTS Retention was predicted by positive affect at 3 and 12 months. There was a higher 12-month abstinence rate among those who were assigned to the mood-management intervention and had initial low positive affect. CONCLUSIONS The study supports the inclusion of mood-management tools in smoking cessation interventions and indicates that positive affect increases persistence to quit smoking.
Experimentally induced psoriatic lesion associates with interleukin (IL)‐6 in mast cells and appearance of dermal cells expressing IL‐33 and IL‐6 receptor

Mast cells are involved in the development of psoriatic lesion, but it is not known how mast cells are activated or whether mast cell cytokines are expressed during the lesion development. In this study, the Köbner reaction was induced in uninvolved psoriatic skin of 18 patients using the tape‐stripping technique, and a sequence of biopsies was collected at 0 days, 2 h and 3 days or at 0 days, 1 day and 7 days for histochemical analysis. Eight patients developed the Köbner reaction verified at the follow‐up visit 2–2·5 weeks later. No significant differences were observed in total tryptase+ mast cells, psoriasis area and severity index and age/sex. Instead, the percentage of tryptase+ mast cells showing interleukin (IL)‐6 immunoreactivity was significantly higher in biopsies from Köbner‐positive patients than in those from Köbner‐negative patients. IL‐33 is a known inducer of IL‐6 in mast cells, and the number of IL‐33+ cells increased significantly in Köbner‐positive dermal skin at days 3–7. The number of dermal cells with IL‐6 receptor (IL‐6R, CD126) also increased in Köbner‐positive skin at days 3–7. Unexpectedly, the number of IL‐6R+ cells was even higher in Köbner‐negative skin at days 3–7. In the chronic plaque of 10 other psoriatic patients, the numbers of IL‐6+ mast cells and dermal cells showing IL‐6R were higher than those in the non‐lesional skin. In conclusion, the positive Köbner reaction is associated with IL‐6 in mast cells and appearance of IL‐6R+ and IL‐33+ dermal cells. This suggests that a previously unrecognized vicious circle may develop in the early psoriatic lesion.
Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase.

The Saccharomyces cerevisiae rad6, rad18, and rad52 mutants exhibit DNA repair deficiencies and distinct mutator phenotypes. DNA replication past unrepaired spontaneous damage might contribute to the specificities of these mutators. Because REV3 is thought to encode a DNA polymerase that specializes in translesion synthesis, we determined the REV3 dependence of the rad mutator specificities. Spontaneous mutagenesis at a plasmid-borne SUP4-o locus was examined in isogenic strains having combinations of normal or mutant REV3 and RAD6, RAD18, or RAD52 alleles. For the rad6 and rad18 mutators, the mutation rate increase relied largely, but not exclusively, on REV3 whereas the rad52 mutator was entirely REV3 dependent. The influence of REV3 on the specificity of the rad6 mutator differed markedly depending on the mutational class examined. However, the requirement of rev3 for the production of G.C-->T.A transversions by the rad18 mutator, which induces only these substitutions, was similar to that for rad6-mediated G.C-->T.A transversion. This supports a role for the Rad6-Rad18 protein complex in the control of spontaneous mutagenesis. The available data imply that the putative Rev3 polymerase can process a variety of spontaneous DNA lesions that normally are substrates for error-free repair.
Quantification of Circulating Varicella-Zoster Virus DNA for Follow-up in a Case of Visceral Varicella-Zoster Infection Ameliorated with Intravenous Acyclovir

We describe a patient with acute lymphocytic leukemia (ALL) who developed visceral varicella-zoster virus (VZV) infection following cord blood stem cell transplantation (CBSCT) and was successfully treated with intravenous acyclovir (ACV). A 24-year-old woman with ALL developed severe epigastric pain 168 days after CBSCT, followed by blistering eruptions 2 days later. A diagnosis of visceral varicella-zoster disease was made, and early intravenous ACV therapy successfully alleviated the epigastric pain and skin lesions within 2 weeks. Polymerase chain reaction analysis of the serum showed dramatic decreases in the viral DNA copy number and revealed large viral concentrations prior to the skin manifestations. The viral DNA copy number in whole blood remained positive, however, but was reduced. Further treatment with intravenous ACV led to VZV DNA becoming undetectable in whole blood, a result not achieved with oral valacyclovir.
Changes in medical students’ motivation and self-regulated learning: a preliminary study

Objectives To investigate whether medical students’ motivation and Self-Regulated Learning (SRL) change over time to enhance our understanding of these constructs as dependent variables in medical education. Methods A cohort of first-year students (n=43) at a medical school in South Korea completed a self-report questionnaire on motivation and SRL - the Motivated Strategies for Learning Questionnaire (MSLQ). The same questionnaire was administered to the same cohort in the beginning of Year 2. A Wilcoxon signed-rank test was conducted to determine if changes in participants’ MSLQ scores occurred between in Years 1 and 2. Results Forty-one students completed the questionnaires in both years (95% response rate). Participants’ motivation scores significantly increased, whereas their SRL scores decreased significantly after they went through Year 1. The most notable change in participants’ MLSQ scores was in the increase in their test anxiety. There was a positive association between the participants’ test anxiety and their cognitive strategies use in Year 1, which changed to a negative one in Year 2. Meanwhile, participants’ test anxiety scores and their self-regulation scores became more negatively associated over time. Conclusions Our study shows that even as medical students become more motivated, they actually use fewer self-regulated strategies over time. Our findings highlight the need for change in the medical school’s learning environment to lessen students’ test anxiety to facilitate their use of cognitive and meta-cognitive strategies.
Bony landmarks of the medial orbital wall: An anatomical study of ethmoidal foramina

The study determines the distribution patterns of ethmoidal foramina (EF) evaluate how they are affected by gender or bilateral asymmetry, and highlights the surgical implications on the anatomical landmarks of the orbit. Two hundred and forty‐nine dry orbits were assessed. The number and pattern of EF were determined and distances between the anterior lacrimal crest (ALC), anterior (AEF) middle (MEF), posterior (PEF) ethmoidal foramina and between PEF and the optic canal (OC) were measured. The patterns of EF were classified as type I (single foramen) in 4 orbits (1.6%), type II (double foramina) in 152 (61%), type III (triple foramina) in 71 (28.5%), and type IV (multiple foramina) in 22 orbits (16.4%). Two orbits were found with five EF and a single orbit with six EF. A significant gender difference was observed for ALC‐AEF distance (P ≤ 0.03), in males 23.53 ± 2.86 (20.67–26.39) versus females 22.51 ± 3.72 (18.79–26.23) mm. Bilateral asymmetry was observed for ALC‐AEF distance (P ≤ 0.01). The distances ALC‐AEF and ALC‐PEF varied significantly according to EF classification (P ≤ 0.03 and P ≤ 0.02). The navigation ratio from ALC‐AEF, AEF‐PEF, and PEF‐OC, in Greek population was “23‐10‐4 mm”. A variation in the number of EF was found, ranging from 1 to 6, with the first report of sextuple EF. Although measures were generally consistent across genders and side, there are significant differences across ethnicities. These findings suggest that surgeons must consider population differences in determining the anatomical landmarks and navigation points of the orbit. Clin. Anat. 570–577, 2014. © 2013 Wiley Periodicals, Inc.