Miracle-dz/UniFAR-FTUs huggingface dataset:
CHARACTERIZATIO OF A TIMICROBIAL, A TIOXIDA T, A TICA CER PROPERTIES A D CHEMICAL COMPOSITIO OF MALAYSIA A DROGRAPHIS PA ICULATA LEAF EXTRACT

This study was carried out to characterize antimicrobial and antioxidant activities of Malaysian Andrographis paniculata leaf extract. The main objective of the present study is to reveal the potential of A. paniculata leaf to be used as antimicrobial and antioxidant agent for aquaculture feed use. Antimicrobial property of A. paniculata leaf extract against Aeromonas hydrophila, Escherichia coli, Edwardsiella tarda, Flavobacterium sp. , Klebsiella sp. , Salmonella sp. , Vibrio alginolyticus, V. parahaemolyticus, V. cholerae and Pseudomonas aeruginosa. was revealed by using broth micro-dilution method whereas anticancer activity of the extract was determined with Colorimetric MTT (tetrazolium) assay against human breast adenocarcinoma (MCF-7). Compounds of the plant extract were screening and identified by using gas chromatography-mass spectrometry (GC-MS). Antioxidant activity of the plant extract was also characterized by using α, α-diphenyl-β-picrylhydrazyl (DPPH) radical scavenging method. The result of the present study showed that A. paniculata leaf extract possesses antimicrobial, antioxidant and anticancer activities. The minimum inhibitory concentration (MIC) values were ranged from 31.25 to 125 mg/l in which the plant extract was found can inhibit the growth of Edwardsiella tarda Escherichia coli, Flavobacterium sp. , Pseudomonas aeruginosa and Vibrio cholerae at 31.25 mg/l, Aeromonas hydrophila, Klebsiella sp, Salmonella sp. and Vibrio alginolyticus at 62.5 mg/l and it was able to control the growth of and Vibrio parahaemolyticus at 125 mg/l. The plant extract’s antioxidant activity was recorded almost same like Quercetin at the concentration of 10 ppt whereas the value of IC50 of the plant extract against MCF-7 cell was 20.72 ± 1.10 μg/ml. A total of 16 chemical compound were identified (n-hexadecanoic acid, 7.65 %, 9,12,15Octadecatrienoic acid, methyl ester, (Z,Z,Z)-, 6.58 %, β-sitosterol, 6.35 %, α-DGlucopyranoside, methyl, 5.12 %, 9,12,15-Octadecatrienoic acid, ethyl ester, (Z,Z,Z)5.05 %, 2H-1-Benzopyran-6-ol,3,4-dihydro-2,8-dimehtyl-2-(4,8,12-trimethyltridecyl)4.20 %, Phytol, 4.17 %, Pentadecanoic acid, 14-methyl-, methyl ester, 3.47 %, Methyl 2-O-benzyl-βD-xylopyranoside, 2.68 %, 9, 12-Octadecadienoic acid (Z, Z)-, 2.61 %, 3-phenylpropanoic acid, 4-hexadecyl ester, 2.48 %, Heneicosanoic acid, 9,12-Octadecadienoic acid, methyl ester, (E,E)-, 1.72 %, Oleic acid, 1.72 %, Cholest-5-en-7-one, 3-fluoro-, (3 β)-, 1.61 %, Glycerin, 1.27 % and 4H-Chromene-3-carbonitrile, 2-amino-7-benzyloxy-4-cyclohex-3enyl-, 1.10 %). The findings of this study indicating that methanol extract of A. paniculata leaf extract possess high antimicrobial and antioxidant properties.
Modelling Referential Choice in Discourse : A Cognitive Calculative Approach and a Neural Network Approach

In this paper, we discuss referential choice – the process of referential device selection made by the speaker in the course of discourse production. We aim at explaining the actual referential choices attested in the discourse sample. Two alternative models of referential choice are discussed. The first approach of Kibrik (1996, 1999, 2000) is the cognitive calculative approach. It suggests that referential choice depends on the referent’s current activation score in the speaker’s working memory. The activation score can be calculated as a sum of numeric contributions of individual activation factors, such as distance to the antecedent, protagonisthood, and the like. Thus, a predictive dependency between the activation factors and referential choice is proposed in this approach. This approach is cognitively motivated and allows one to offer generalization about the cognitive system of working memory. The calculative approach, however, cannot address non-linear interdependencies between different factors. For this reason we developed a mathematically more sophisticated neural network approach to the same set of data. We trained feed-forward networks on the data. They classified up to all but 4 instances correctly with respect to the actual referential choice. A pruning procedure allowed to produce a minimal network and revealed that out of ten input factors five were sufficient to predict the data almost correctly, and that the logical structure of the remaining factors can be simplified. This is a pilot study necessary for the preparation of a larger neural network-based study.
Equipment Layout Improvement for Large-Scale Hot Cell Facility Logistics

This study presents approaches to equipment layout improvement for a large-scale hot cell facility. First, the original facility layout and target process are introduced, including the basic information and specifications. Second, the flow of process materials is analyzed and the relationships are evaluated in detail using a “from-to chart” and a “relationship chart” for the original layout, and the logistics are simulated using the selected discrete event simulator to calculate the traveling distances of process materials handled by teleoperated material handling systems. Third, the original layout is modified using the total closeness rating (TCR), and the efficiency and usage of the material handling system are calculated and compared with the original case to evaluate the efficiency improvement of the modified layout. This modification process, which included load reduction, enabled those aspects of the material handling system that would need to be changed to be identified; these changes were suggested by a quantitative analysis of the logistics between each pair of stations and intuitive rearrangement based on charts and figures. These approaches could be an initial step in the large-scale hot cell design process, with future work to follow.
Solid state fermentation for cellulase production

• Received: 19 December 2014 • Revised: 15 January 2015• Accepted: 04 February 2015•Published: 08 March 2015 • ABSTRACT Successful utilization of cellulosic material as a renewable carbon source depends on the development of economically feasible process technologies for the production of cellulose. This enzyme has various industrial applications and is now considered as major group of industrial enzyme. The review discusses the advantages of cellulase production by solid state fermentation as compared to submerged fermentation, the types of cellulolytic bacteria and different agro-industrial wastes utilized for cellulose production. The biotechnological aspect of cellulase research and their future prospects are also discussed.
Flytrapping in Tasmania: effective use of traps in a cool temperate climate

Flystrike risk is determined by a combination of fly population, number of susceptible sheep and the suitability of the environment. Wardhaugh and Morton (1990) reported that the incidence of flystrike was related to the log density of gravid females in the area during the previous week, this factor accounting for 33% of the variation in crutch strike and 50% for body strike. As a result of the log relationship, reduction of fly numbers by 70% would be necessary to reduce flystrike by 50%. To be effective with respect to reduction of on-farm costs a much greater reduction in flystrike would be necessary and it is likely that the traps would need to capture more than 90% of the available flies. Therefore even small reductions in trap efficiency (e.g. catching only 50% of available flies) would render the traps relatively ineffective.
Power to the Powerless: Interpersonal Influence through Sympathy Appeals by Aiwa Shirako A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Business Administration in the Graduate Division

1 TABLE OF CONTENTS . i DEDICATION . ii ACKNOWLEDGEMENTS . iii PREFACE . iv CHAPTER 1: Theoretical background and literature review . 1 CHAPTER 2: Sympathy elicitation in negotiations . 9 CHAPTER 3: Preference reversals in sympathy-based decisions . 24 CHAPTER 4: Sympathy and power. 35 CHAPTER 5: Conclusions and future directions . 44 REFERENCES. 48 FOOTNOTES . 60 TABLES . 62 FIGURES . 67 APPENDIX . 69
Experimental Investigation on the Dynamic Properties of RC Structures Affected by the Reinforcement Corrosion

Reinforcement concrete (RC) structures in service are suffered from environmental attacks, especially the rebar corrosion, which may lead to the deterioration of mechanical characteristics of steel bars, surrounding concrete and bond strength, and therefore jeopardize their performance in earthquake events. In this paper, an electro-chemical accelerated corrosion process was introduced to RC frames and columns, and then the half-cell method, linear polarization method and constant potential step method were performed to monitor the corrosion status. Furthermore, for studying the dynamic properties of RC structures affected by reinforcement corrosion, the dynamic tests were carried out to study the fundamental frequency and damping ratio of control frame and frames which designed steel losses were 10% and 30%, respectively. The experimental results show that the influence of corrosion damage on fundamental frequency and damping ratio is significant. Substantial increases were observed in fundamental frequency and damping ratio after the accelerated corrosion occurred. It indicates that the decreased bond strength or ultimate bearing capacity cannot ensure that the stiffness of healthy member is always greater than that of damaged member. Moreover, the variations of frequency and damping ratio, induced by steel corrosion, are not inconsistent. This investigation provides further insight into the use of fundamental frequency and damping ratio to detect damage of RC structures.
High pressure behaviour of lead feldspar ( PbAl 2 Si 2 O 8 )

M. Hanfland European Synchrotron Radiation Facility (ESRF), B.P. 220, F-38043, Grenoble, France Abstract An in situ high pressure powder diffraction study, using high-brilliance synchrotron radiation, on lead feldspar (PbAl2Si2O8) was performed. Two samples, with Qod=0.68 and 0.76, were loaded in a diamond anvil cell and were compressed up to 11 GPa. Up to P=7.1 GPa the only phase present is lead feldspar. In the range 7.1±9.4 GPa sudden changes in the position of the reflections suggest the transformation of lead feldspar to a new phase (probably feldspar-like). The absence of split that would be compatible with triclinic symmetry rules out the monoclinic-triclinic transition, that was reported for the structurally similar strontium feldspar. At P>9.4 GPa some new extra reflections not indexable in the feldspar cell are present as well. During decompression the lead feldspar was the only phase present at P<6 GPa. Peak enlargement was observed with pressure, probably preliminary to amorphization. However almost complete amorphization was observed only after fortuitous shock compression at 18 GPa; the crystallinity was recovered at room pressure after decompression. The bulk modulus for lead feldspar was K=71.0(9) and 67.6(1.2) GPa for the two samples, in the range reported for feldspars. The cell parameters show a compression pattern which is similar to that observed in anorthite, with Da/a0>Dc/c0>Db/b0; comparison with the high temperature behaviour shows that for lead feldspar the strain tensor with pressure is more isotropic and the deformation along a is less prominent. A turnover in the behaviour of the b angle with pressure suggests a change in the compression behaviour at P 2 GPa. Rietveld refinement of the Pb coordinates was performed in a series of spectra with pressure ranging from 0.6 to 6.5 GPa. The combined analysis of cell parameters and Pb coordinates with pressure showed that the compression of the structure is mainly achieved by an approach of Pb atoms along a*.
Patients : LiDCO rapid TM System Uncalibrated Continuous Cardiac Output Measurement in Liver Transplant versus Pulmonary Artery Catheter

Objective: The aim of the study was to assess the level of agreement between continuous cardiac output estimated by uncalibrated pulse-power analysis (PulseCOLiR) and intermittent (ICO) and continuous cardiac output (CCO) obtained using a pulmonary artery catheter (PAC). Design: Prospective cohort study. Setting: University hospital intensive care unit. Participants: Twenty patients after liver transplantation. Intervention: Pulmonary artery catheters were placed in all patients, and ICO and CCO were determined using thermodilution. PulseCOLiR measurements were made using a LiDCOrapid (LiDCO Ltd, Cambridge, UK). Measurements and Main Results: ICO data were determined after intensive care unit admission and every 8 hours until the 48th postoperative hour. CCO and PulseCOLiR measurements were recorded simultaneously at these same time intervals as well as hourly. For the 8-hour data set (140
, James Mechanism and Allosteric Integrase Inhibitor ReplicationHuman Cells : Analyses of HIV-1 Gene in PSIP 1 TALEN Knockout of the

HIV-1 utilizes the cellular protein LEDGF/p75 as a chromosome docking and integration cofactor. The LEDGF/p75 gene, PSIP1, is a potential therapeutic target because, like CCR5, depletion of LEDGF/p75 is tolerated well by human CD4 T cells, and knockout mice have normal immune systems. RNA interference (RNAi) has been useful for studying LEDGF/p75, but the potent cofactor activity of small protein residua can be confounding. Here, in human cells with utility for HIV research (293T and Jurkat), we used transcription activator-like effector nucleases (TALENs) to completely eradicate all LEDGF/p75 expression. We performed two kinds of PSIP1 knockouts: whole-gene deletion and deletion of the integrase binding domain (IBD)-encoding exons. HIV-1 integration was inhibited, and spreading viral replication was severely impaired in PSIP1 / Jurkat cells infected at high multiplicity. Furthermore, frameshifting the gene in the first coding exon with a single TALEN pair yielded trace LEDGF/ p75 levels that were virologically active, affirming the cofactor’s potency and the value of definitive gene or IBD exon segment deletion. Some recent studies have suggested that LEDGF/p75 may participate in HIV-1 assembly. However, we determined that assembly of infectious viral particles is normal in PSIP1 / cells. The potency of an allosteric integrase inhibitor, ALLINI-2, for rendering produced virions noninfectious was also unaffected by total eradication of cellular LEDGF/p75. We conclude that HIV-1 particle assembly and the main ALLINI mechanism are LEDGF/p75 independent. The block to HIV-1 propagation in PSIP1 / human CD4 T cells raises the possibility of gene targeting PSIP1 combinatorially with CCR5 for HIV-1 cure.
Molecular Cell Recognition of 5 hmC by the SRA Domain of UHRF 2

Ting Zhou,1,2 Jun Xiong,3 Mingzhu Wang,1 Na Yang,1 Jiemin Wong,4 Bing Zhu,3 and Rui-Ming Xu1,* 1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 2University of Chinese Academy of Sciences, Beijing 100049, China 3National Institute of Biological Sciences, Beijing 102206, China 4Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China *Correspondence: rmxu@sun5.ibp. ac.cn http://dx.doi. org/10.1016/j.molcel. 2014.04. 003
CHILDREN ’ S LATENT TRAIT CORTISOL –

Adversity experienced early in life has the potential to influence physical health later in life. The stresshealth relation may be partially explained by stress-related effects on cardiovascular risk factors. This study explored links between individual differences in trait-like variation in the activity of the hypothalamic-pituitary-adrenal (HPA) axis with cardiovascular risk factors in children. 474 children (M age = 9.22 years; 54% female; 83% Caucasian) were included in this study, in which cardiovascular risk was assessed using the following indices – triglycerides (TG), HDL-cholesterol (HDL-C), glucose (Glu); resting systolic and diastolic blood pressure, body mass index (BMI), waist-to-hip ratio, and % fat. Saliva samples were measured 3 times a day (waking, 30 minutes post-waking and bedtime) over 3 days (later assayed for cortisol). A latent trait cortisol (LTC) factor explained 43% of the variance in cortisol levels within and across days. Confirmatory factor analysis identified three cardiovascular risk factors: lipids (i.e., TG and HDL-C), blood pressure (i.e., systolic and diastolic), and body composition (i.e., BMI, Waist-to-hip ratio, and % fat). Lower salivary LTC was associated with higher lipids, higher blood pressure, and higher body composition. The findings further support the internal and external validity of the LTC construct, and may also advance our understanding of the link between interindividual differences in HPA axis activity and cardiovascular risk in middle childhood.
On the possibility and driving forces of secular stagnation

This paper investigates the possibility of today’s OECD economies entering into a very long period of poor per capita economic growth and very low real interest rates. We construct a general equilibrium model with overlapping generations of heterogeneous individuals, differing in ability and human capital, and with genetic and financial transfers from parents to children. Our model allows to study within one coherent framework the effects of those factors that are most often mentioned in the literature as possible drivers of secular stagnation: demographic change, a slowdown in the rate of technical progress, rising inequality, borrowing constraints, and downward rigidity in the real interest rate. We calibrate our model to Belgium and find that its predictions match key facts in Belgium in 1950-2009 very well. We then simulate projected future changes in technical progress and demography. In alternative scenarios we additionally impose rising inequality, borrowing constraints and/or a lower bound to the real interest rate. When we assume unchanged public policies and a modest future rate of technical progress, our conclusions about future per capita output and growth are rather pessimistic. Demographic change is by far the most influential cause of low growth. If a lower bound to the real interest rate is binding, it could considerably aggravate the problem of stagnation.
Individual and combined influence of ACE and ACTN 3 genes on muscle phenotypes in Polish athletes Running head : ACE and ACTN 3 genes and athletes ’ muscle phenotypes

1 Department of Nutrition Physiology and Dietetics, Institute of Sport – National Research Institute, Warsaw, Poland 2 Department of Biomechanics, Institute of Sport – N ational Research Institute, Warsaw, Poland 3 Institute of Physical Culture, Kazimierz Wielki Un iversity, Bydgoszcz, Poland 4 Department of Statistic, Józef Piłsudski Universit y of Physical Education in Warsaw, Warsaw, Poland Corresponding author: Orysiak Joanna, Department of Nutrition Physiology and Dietetics, Institute of Sport – National Research Institute, Str. Trylogii 2/16, 01-982 Warsaw, Poland Phone: (0-22) 569-99-47 e-mail joanna.orysiak@insp.waw. pl
Metalloproteinase Enzymes in Rectal Cancer Patients Undergoing Chemoradiotherapy Effect of Conjugated Linoleic Acid Supplementation on Inflammatory Factors and Matrix-Oct

Objectives. The aims of this study were to determine the effect of conjugated linoleic acid (CLA) supplementation on inflammatory factors and matrix metalloproteinase (MMP) enzymes in rectal cancer patients undergoing chemoradiothetrapy. Method and Material. In this randomized, double-blind, placebo-controlled pilot study, 34 volunteer patients with rectal cancer undergoing chemoradiotherapy assigned into the CLA group (n = 16), receiving 3 g CLA/d, and placebo group (n = 18) receiving placebo capsules (sunflower oil) for 6 weeks. The supplementation began 1 week before starting RT (loading period) and continued every day during treatment. Before and after intervention, serum tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), IL-6, MMP-2, MMP-9, and high-sensitivity C-reactive protein (hsCRP) were measured by enzymelinked immunosorbent assay (ELISA) kits and immunoturbidimetric method, respectively. Independent t tests and paired t tests were used to compare parameters between and within groups, respectively. Results. In the CLA group, the mean serum TNF-α, IL-1β, hsCRP, MMP-9, and MMP-2 levels reduced insignificantly. However, significant changes in TNF-α (P = 0.04), hsCRP (P = 0.03), and MMP-9 (P = 0.04) concentrations were observed in the CLA group when compared with the placebo group. The mean serum IL-6 level remained unchanged in the CLA group but increased remarkably in the placebo group. Conclusion. According to our results, CLA supplementation improved inflammatory factors, MMP-2, and MMP-9 as biomarkers of angiogenesis and tumor invasion. It seems that CLA may provide new complementary treatment by reducing tumor invasion and resistance to cancer treatment in patients with rectal cancer.
INVESTIGATION OF HEAT RELEASE RATE OF BIODIESEL PILOT FUELLED NATURAL GAS ENGINE WITH STOCHASTIC REACTOR MODEL

In this study, heat release rate (HRR) characteristics of natural-gas (NG) dual-fuel (DF) engine using biodiesel pilot fuel were investigated by stochastic reactor model (SRM). SRM Engine Suite software having solution method in zero-dimensional was used to apply stochastic reactor model into the DF engine. Results of the study were validated by the experimental data obtained from biodiesel pilot fuelled NG engine. Biodiesel surrogate fuel was considered as a mixture of methyl decanoate (25 v%), methyl-9-decenoate (25 v%) and n-heptane (50 v%) and its skeletal kinetic mechanism includes 71 species and 217 reactions. In addition, it is shown that biodiesel surrogate fuel chemical kinetic mechanism could represent soy biodiesel fuel. Case studies were realized under 50, 100, 150 and 200 stochastic particles with 120 MPa pilot fuel injection pressure and 17°BTDC pilot fuel injection timing conditions in the simulations. It was observed that SRM method is a good tool to investigate HRR of biodiesel pilot fuelled DF engine.
Economic Analysis of Supplemental Deductible Coverage as Recommended in the USDA's 2007 Farm Bill Proposal

A primary change to crop insurance contained in the USDA's Farm Bill proposal is supplemental deductible coverage (SDC). SDC would allow farmers who purchase individual crop insurance coverage to purchase area-wide coverage in the amount of the individual policy deductible. This supplemental area-wide coverage would be similar to the existing Group Risk Plan policy, but with an accelerated indemnity schedule. Analysis indicates that SDC increases farmer certainty equivalents. The largest benefits are realized by farmers with high yield potential in counties with greater systemic risk. In general, optimal individual policy coverage levels modestly decrease when SDC is taken.
Working memory enhances target detection in the blind hemifield

ABSTRACT Visual perception can be influenced by the content of working memory. Previous studies have shown this influence can be enough to improve unconscious visual discrimination in healthy participants and conscious visual discrimination in neuropsychological patients with extinction. Here, these findings are extended by examining the effects of holding an object in working memory on unconscious visual perception in a person with hemianopia. The results revealed significantly enhanced detection accuracy when there was an exact match between the colour and orientation of the discrimination target and the item in working memory. However, the facilitatory effect was greatly reduced when only colour or orientation was matched with the item being held in memory. A control experiment confirmed these effects were not due to visual priming. These results are consistent with the proposal that working memory guided perceptual facilitation is driven by signal enhancement. More broadly, the data are interpreted in terms of a biased competition account of visual perception.