Miracle-dz/UniFAR-FTUs huggingface dataset:
Central Line-Associated Infections as Defined by the Centers for Medicare and Medicaid Services' Hospital-Acquired Condition versus Standard Infection Control Surveillance Why Hospital Compare Seems Conflicted

Objective. To evaluate the concordance of case-finding methods for central line-associated infection as defined by Centers for Medicare and Medicaid Services (CMS) hospital-acquired condition (HAC) compared with traditional infection control (IC) methods. Setting. One tertiary care and 2 community hospitals in North Carolina. Patients. Adult and pediatric hospitalized patients determined to have central line infection by either case-finding method. Methods. We performed a retrospective comparative analysis of infection detected using HAC versus standard IC central line–associated bloodstream infection surveillance from October 1, 2007, through December 31, 2009. One billing and 2 IC databases were queried and matched to determine the number and concordance of cases identified by each method. Manual review of 25 cases from each discordant category was performed. Sensitivity and positive predictive value (PPV) were calculated using IC as criterion standard. Results. A total of 1,505 cases were identified: 844 by International Classification of Diseases, Ninth Revision (ICD-9), and 798 by IC. A total of 204 cases (24%) identified by ICD-9 were deemed not present at hospital admission by coders. Only 112 cases (13%) were concordant. HAC sensitivity was 14% and PPV was 55% compared with IC. Concordance was low regardless of hospital type. Primary reasons for discordance included differences in surveillance and clinical definitions, clinical uncertainty, and poor documentation. Conclusions. The case-finding method used by CMS HAC and the methods used for traditional IC surveillance frequently do not agree. This can lead to conflicting results when these 2 measures are used as hospital quality metrics.
How Men’s Sexual Assault Victimization Experiences Differ Based on Their Sexual History

This study examined the differences in men’s sexual assault victimization experiences based on their history of only having sex with women (MSW) or having sex with women and men (MSW/M). Based on the previous research, we expected that MSW/M would be more likely to report a sexual assault history, experience a significantly greater number of sexual assault acts, experience more severe levels of unwanted sexual activity and tactics (i.e., physically forced attempted or completed rape), and report both male and female perpetrators, compared with MSW. Community, nonproblem drinking men, ages 21 to 30 (N = 311), reported on their sexual assault victimization experiences since age 14 using a modified version of the Sexual Experiences Survey. Six items were used to assess participants’ number of unwanted sexual experiences (i.e., unwanted sexual contact, attempted and completed rape) that included the use of intoxication, physical force, both, or neither. For each item, participants indicated if the perpetrator(s) was/were male, female, or both male and female. Two fifths of men reported experiencing sexual assault, the majority of which involved attempted or completed rape. Replicating and extending previous research, MSW/M were significantly more likely to be victims (65% vs. 39%), experienced a significantly greater number of sexual assault acts since age 14, were more likely to have experienced attempted or completed rape through the use of physical force, and were more likely to report male only or both male and female perpetrators across their victimization experiences, as compared with MSW. Results indicate a clear need for additional research on the unique victimization experiences of MSW/M. Additionally, sexual assault prevention programming needs to provide men with the skills to identify and negotiate unwanted sexual advances made by men and women and to promote healthy sexual relationship behaviors.
Full employment in Europe

Transitional Labour Markets (TLM) – defined as legitimate, negotiated and politically supported sets of various employment options in critical events over the life course – are an essential ingredient of modern full employment strategies. After assessing the European Employment Strategy, this book offers a detailed comparative analysis of employment performance for selected European member states and the United States. It suggests that successful employment systems arise from a new paradigm of flexibility and security (‘flexicurity’) the balance of which varies according to countries’ institutional paths. Whilst there is no ‘best practice’, TLM theory does provide normative and analytical principles that can be generalised for various institutional settings. The book also provides good practice examples for managing critical transitions over the life course – from education to employment, from one job to another, from unemployment to employment, from private activities to gainful work and from employment to retirement – and develops the contours for extending unemployment insurance to work–life insurance.
Shopping in downtown

Purpose – The purpose of this study is to analyse the influence of three selected physical components of the urban environment – physical design, space layout and functionality, and store external appearance – on consumers' perceptions of service quality and behavioural intentions (desire to stay and repatronage intentions). Design/methodology/approach – The research framework is based on the atmospherics, servicescape and service quality literatures. The proposed model is tested with a survey conducted in an inner‐city shopping street in Benevento (Italy). Findings – Results show that physical space functionality and store appearance provide cues upon which customers base their perception of service quality provided in the shopping street and that service quality inferences, in turn, are able to affect desire to stay and repatronage intentions.Practical implications – Findings are able to provide policy makers and retailers with suggestions in developing appropriate strategies for managing the urban settin.
Effects of Experiences and Brand-Self Image Congruity on Perceived Risk and Purchase Intention in Apparel Online Shopping Context

Retailers’ ultimate concern is consumers' purchase intentions because increasing levels of purchase intention may lead to the actual purchase, which is directly related to retailers’ sales and profits. Perceived risk has been proposed as one of the most important concepts for understanding how consumers make a purchase decision (Mitchell, 1999) and research findings supported that perceived risk was a significant factor affecting consumers’ willingness to purchase (Heijden, Verhagen, & Creemers, 2001). Therefore, it is critical for online retailers in the apparel industry to understand consumer’s perceived risk and purchase intention so that they can develop effective retail strategies and build long-term relationships with customers. Consumers use internal information to help them in the purchase decision process by retrieving risk-related information from memory. Experience and product/brand knowledge are two common types of internal information that consumers use to reduce risks and make purchase decisions (Brucks, 1985; Engel, Blackwell, & Miniard, 1995). Studies showed that experience with previous in-home shopping for apparel products significantly reduced perceived risk and increased purchase intention in buying apparel products via in-home shopping channels (Kwon, Paek, & Arzeni, 1991; Park & Stoel, 2005; Sen, Johnson, Stanforth, Lennon, & Moore, 2000). Several researchers also have investigated the relationship between the familiarity with a website’s brand and the perceived of risk and purchase intention (Laroche, Kim, & Zhou, 1996; Park & Stoel, 2005). However, the brand familiarity in these studies was measured as consumer’s brand knowledge through frequent exposures, such as advertisement, instead of experiences
Randomized double blind trial of an ayurvedic plant derived formulation for treatment of rheumatoid arthritis.

OBJECTIVE To evaluate RA-1, a standardized plant extract formulation, traditionally considered a safe, effective antiarthritic in the Asian-Indian Ayurvedic medicinal system. METHODS One hundred eighty-two patients with active-on-chronic rheumatoid arthritis (RA) participated in a 16 week randomized, double blind, placebo controlled, parallel efficacy clinical drug trial in Pune, India. Tenderness, pain, swelling, and several other efficacy measures were assessed by (1) ACR core set 20% and 50% improvement; (2) ACR 20% improvement response. An intent-to-treat analysis was performed; p<0.05 considered significant. RESULTS Seventeen patients withdrew (active = 9; placebo = 8); none withdrew due to drug toxicity. An unprecedented placebo response (often p<0.001 in within-group change) was observed. The active RA-1 group remained numerically superior at all evaluation timepoints. RA-1 demonstrated few significant differences: (1) increased proportion with 50% reduction in swollen joint count (95% CI approximately 1.52, 29.90) and swollen joint score (95% CI approximately 0.91, 28.73); (2) reduced rheumatoid factor (95% CI approximately -303.7, -2.72); 39% in the RA-1 group versus 30% placebo showed ACR 20% improvement (95% CI approximately -5.48, 24.59). Only minor side effects were seen, with no significant differences by treatment group. CONCLUSION In a trial with sufficient power, RA-1 revealed efficacy that was not significantly superior to the strong placebo response, except for improvement in joint swelling. Further, the effect on RF and good safety profile led to an open label phase.
Engineering hepatocyte functional fate through growth factor dynamics: the role of cell morphologic priming.

We have reported previously that cellular stimulation induced by variable mechanochemical properties of the extracellular microenvironment can significantly alter liver-specific function in cultured hepatocytes (Semler et al., Biotech Bioeng 69:359-369, 2000). Cell activation via time-invariant presentation of biochemical growth factors was found to either enhance or repress cellular differentiation of cultured hepatocytes depending on the mechanical properties of the underlying substrate. In this work, we investigated the effects of dynamic growth factor stimulation on the cell growth and differentiation behavior of hepatocytes cultured on either compliant or rigid substrates. Specifically, hepatotrophic growth factors (epidermal and hepatocyte) were either temporally added or withdrawn from hepatocyte cultures on Matrigel that was crosslinked to yield differential degrees of mechanical compliance. We determined that the functional responsiveness of hepatocytes to fluctuations in GF stimulation is substrate specific but only in conditions in which the initial mechanochemical environment induced significant cell morphogenesis. Our studies indicate that in conditions under which hepatocytes adopted a "rounded" phenotype, they exhibited increased levels of differentiated function upon soluble stimulation and markedly decreased function upon the depletion of GF stimulation. In contrast, hepatocytes that assumed a "spread" phenotype exhibited slightly increased function upon the depletion of GF stimulation. By examining the functional responsiveness of hepatocytes of differential morphology to varied fluctuations in GF activation, insights into the ability of cell shape to "prime" hepatocyte behavior in dynamic microenvironments were elucidated. We report on the possibility of uncoupling and, thus, selectively manipulating, the concerted contributions of GF-induced cellular activation and substrate- and GF-induced cell morphogenesis toward induction of cell function.
Cancer caregiver quality of life: need for targeted intervention

Caregiving can negatively impact well‐being. Cancer caregivers face unique challenges given the intense nature of cancer and treatment, which increases their risk for burden, poor quality of life (QOL), and burnout. Studies to reduce caregiver burden demonstrate QOL improvement and distress reduction in the short term. However, few studies exist to address long‐term benefits. We assessed changes in various QOL domains after participation in a QOL intervention for caregivers of patients having newly diagnosed advanced cancer.
Durations between Equity and Debt Issues and Their Effect on the Offering Announcement Returns

This study examines (1) durations between equity and debt offerings over the corporate lifecycle, (2) the factors that explain variations in the time to equity or debt issue, and (3) the relation between the market reaction to equity and debt issue announcements and the duration between offerings. We report that after the Initial Public Offering (IPO), the first seasoned equity issue is quicker than the first seasoned debt issue. However, for subsequent seasoned offerings, debt issues are quicker than equity. Using duration analysis, we show that shorter durations between equity and debt issues are explained by stock mispricing, VC-backing of the stock at the IPO, measures of information asymmetry, stock liquidity, deviations from target leverage, return volatility, financing gap, firm investments and the choice of public vs. private placement. Also, the time to an equity issue is shorter if the previous issue was of debt. Investors react more unfavorably to equity and debt issues that follow closely from the previous offering. This is because firms with higher information asymmetry and stock mispricing are more likely to quickly issue equity and debt following the previous capital acquisition. Together, our study shows that duration between equity and debt issues signals issuer quality and that investors discount this information in the stock price at the equity and debt issue announcements. JEL classification: G30, G32, C41
Effect of brucellosis vaccination and dehorning on transmission of bovine leukemia virus in heifers on a California dairy.

Brucellosis vaccination and dehorning were examined for an association with bovine leukemia virus (BLV) infection in heifers on a California dairy between April 1984 and June 1987. Between December 1985 and June 1986, weaned heifers were dehorned using the gouge method at the time of brucellosis vaccination. Using logistic regression, the estimated probability for a nondehorned heifer to seroconvert within three months after brucellosis vaccination (0.08) was significantly less than that for heifers dehorned after a noninfected heifer (0.46) or than that for heifers dehorned after an infected heifer (0.85) (p = 0.039 and p less than 0.001, respectively). To evaluate risk of transmission by brucellosis vaccination, which was usually done within one month postweaning, cumulative proportions of heifers remaining uninfected were computed among heifers that did not seroconvert three months after dehorning. Because results of a Cox model analysis indicated that groups of heifers were 6.6 times more at risk of becoming infected if placed in pens holding gouge-dehorned heifers (where prevalence varied between 50 and 70%) (p less than 0.001) than other groups placed in pens without gouge-dehorned heifers (where prevalence varied between 10 and 30%), cumulative proportions of heifers remaining uninfected were computed for each type of group. The cumulative proportion of heifers remaining uninfected from weaning to first calving was 0.60 for the high prevalence group and 0.96 for the low prevalence group. No change in slope of cumulative proportions was observed before and after one month postweaning, suggesting that brucellosis vaccination was not an effective means of transmission. (ABSTRACT TRUNCATED AT 250 WORDS)
Dividends, stock repurchases and signaling: evidence from U.S. panel data

This paper exploits yearly accounting data from 1977 to 1994 to test the relative signaling power of dividends and net stock repurchases. The specification controls for potential agency cost and asset dissipation effects. Specifically, we regress changes in future income before extraordinary items on changes in dividends, changes in net stock repurchases, and a host of control variables. We also split the sample at 1981 to measure the impact of changes in the relative taxation of distribution methods. For the full twenty-year sample, only dividend changes are correlated with changes in future income. Moreover, the dividend coefficient and the repurchases coefficient differ statistically different in every future income equation. Splitting the sample reveals that the pre-1981 subsample drives the full-sample results. Put another way, the empirical link between changes in dividends and changes in future income vanishes just as a revision of the tax law reduced the tax disadvantage of dividend distributions. This evidence supports the notion that, at least for a period in time, firms deliberately exposed shareholders to punitive taxation to signal favorable prospects.
Increased Vitronectin and Endothelin-1 in the Breath Condensate of Patients with Fibrosing Lung Disease

Background: Non-specific interstitial pneumonia (NSIP) and fibrosing alveolitis associated with systemic sclerosis (FASSc) are diseases of unknown aetiology that are characterised by the accumulation of mononuclear cells, followed by the progressive deposition of collagen within the interstitium and subsequent destruction of lung airspace. Better understanding of mediators involved in fibrosis may be useful for early diagnosis and in clinical monitoring of disease progression. Objective: The aim of this study was to investigate the presence of two profibrotic markers, the vitronectin and the endothelin-1 (ET-1) in the airways of NSIP and FASSc patients. Methods: Ten NSIP (6 males, age 57 ± 2 years) and 15 FASSc (8 males, age 55 ± 4 years) patients were recruited along with 10 normal subjects (4 male, age 52 ± 2 years). Vitronectin and ET-1 concentrations were measured in their breath condensate, using a specific enzyme immunoassay. Results: Higher levels of vitronectin and ET-1 were observed in NSIP and FASSc patients [median 92.8 (91.7–93.9) µg/ml; median 8.3 (7.9–9.3) pg/ml] than in control subjects [median 80.3 (89.3–91.4) µg/ml; p < 0.01; median 5.3 (4.9–5.9) pg/ml, p < 0.0001]. We also found increased concentrations of vitronectin in patients with clinical deterioration compared to those remaining stable and in ex-smokers compared to non-smokers and, increased vitronectin and ET-1 in patients treated with steroids compared to untreated patients. Conclusion: These findings justify further studies of vitronectin and ET-1 levels in exhaled breath condensate, as a means of monitoring activity and predicting progression of pulmonary fibrosis.
Hedge Fund Contagion and Liquidity

Using hedge fund indices representing eight different styles, we find strong evidence of contagion within the hedge fund sector: controlling for a number of risk factors, the average probability that a hedge fund style index has extreme poor performance (lower 10% tail) increases from 2% to 21% as the number of other hedge fund style indices with extreme poor performance increases from zero to seven. We investigate how changes in funding and asset liquidity intensify this contagion, and find that the likelihood of contagion is high when prime brokerage firms have poor performance (which would be expected to affect hedge fund funding liquidity adversely) and when stock market liquidity (a proxy for asset liquidity) is low. Finally, we examine whether extreme poor performance in the stock, bond, and currency markets is more likely when contagion in the hedge fund sector is high. We find no evidence that contagion in the hedge fund sector is associated with extreme poor performance in the stock and bond markets, but find significant evidence that performance in the currency market is worse when hedge fund contagion is high, consistent with the effects of an unwinding of carry trades.
Estimating the Effects of Time-Varying Treatments: Incidence of Fractures Among Postmenopausal Japanese Women

Background: In the absence of unmeasured confounding, standard methods for estimating the effects of time-varying treatments on an event are biased when a time-dependent risk factor for the event also predicts subsequent treatments and when past treatment history predicts subsequent risk factor levels. In contrast, structural models provide unbiased estimates of effects when unmeasured confounding is absent. Methods: We describe a multiplicative structural mean model and use it to estimate the effects of time-varying osteoporosis treatments on incidence of fractures among 1328 postmenopausal women over 40 years of age in a hospital-based cohort study in Japan. The parameters of the structural mean model are estimated by g-estimation. Results: The number of vertebral fractures and bone mineral density levels predicted the selection of subsequent treatments and were affected by the previous treatments. Incidence rate ratios of bisphosphonates, active vitamin D3, and conjugated estrogen compared with no drug therapy were 0.58 (95% confidence interval = 0.44−0.77), 0.82 (0.48−1.38), and 0.60 (0.47−0.76), respectively, after adjusting time-dependent confounders. For initial treatments estimated by the standard Poisson-GEE, incidence rate ratios were 1.61 (1.23−2.10), 1.16 (0.96−1.40), and 0.73 (0.52−1.02), respectively. Conclusions: Our analysis using the structural mean model showed that bisphosphonates, active vitamin D3, and conjugated estrogen all had preventive effects on the incidence of fractures by appropriate adjustments for time-dependent confounders. The results from standard Poisson-GEE analysis were the opposite of these results and of evidence from randomized trials. We consider our methods useful to estimate time-varying treatments within observational data.
Effect of Various Sugary Beverages on Salivary pH, Flow Rate, and Oral Clearance Rate amongst Adults

Introduction. Diet is a major aetiological factor for dental caries and enamel erosion. This study was undertaken with the aim of assessing the effect of selected locally available beverages on salivary pH, flow rate, and oral clearance rate amongst adults. Materials and Method. This clinical trial comprised 120 subjects. Test beverages undertaken were pepsi, fruit drink, coffee, and sweetened milk. Statistical analysis was carried out using SPSS version 17. Descriptive statistics, one-way ANOVA, and post hoc Tukey's test were applied in the statistical tests. Results. It was found that salivary pH decreased for all the beverages immediately after consumption and the salivary flow rate increased after their consumption. The oral clearance rate of sweetened milk was found to be the least at 6.5 minutes and that of pepsi was found to be 13 minutes. However, the oral clearance rates of fruit drink and coffee were found to be equal at 15 minutes. Conclusion. Although it was found out that liquids cleared rapidly from the oral cavity, they had a significant cariogenic and erosive potential. Hence, it is always advised to minimise the consumption of beverages, especially amongst children and young adults to maintain a good oral health.
Studies on the aminotransferases participating in the glycolate metabolism of the alga mougeotia.

Microbodies from Mougeotia spec. , Strain 168.80 contain aminotransferases for conversion of glyoxylate to glycine and serine to hydroxypyruvate. Formation of glycine is possible at highest rates with alanine and glutamate as amino donors, whereas for deamination of serine, pyruvate and glyoxylate are the most convenient substrates. A serine hydroxymethyl-transferase was found exclusively in the mitochondrial fraction. There are indications that this enzyme is bound to the mitochondrial membranes. The activities of all transferases are increased under culture conditions stimulating the synthesis of glycolate.