Miracle-dz/UniFAR-FTUs huggingface dataset:
Beta Thalassemia Trait Accompanying Iron Deficiency Anemia

Objective: Anemia is a commonly encountered health problem. In this study, togetherness of beta thalassemia trait with iron deficiency anemia was investigated using by some biochemical and hematological cell count indices. Material and Methods: The 128 specimens of whole blood samples (n = 895) that were sent to our laboratory were selected as beta thalassemia carriers by hematological indices and HbA2 values. The
Responses in HER-2 Transgenic Mice Protective and Therapeutic Antitumor Potent Th Cell Epitopes Induce Distinct HER-2 DNA and Protein Vaccines Containing

Overexpression of the growth factor receptor HER-2 (c-erbB-2, neu ) has transforming potential and occurs in (cid:1) 20–30% of breast and ovarian cancers. HER-2 is a self Ag, but Abs and T cells speciﬁc for HER-2 have been isolated from cancer patients, suggesting HER-2 may be a good target for active immunotherapy. We constructed rat HER-2 DNA and protein vaccines containing potent Th cell epitopes derived from tetanus toxin and studied their potency in two strains of mice transgenic for the rat HER-2 molecule. Vaccination with HER-2 DNA protected nontransgenic mice from tumor challenge, but induced only moderate protection in one of the tumor models. However, vaccination with the modiﬁed HER-2 protein resulted in almost complete protection from tumor challenge in both tumor models. This protection could be mediated by Abs alone. In addition, protein vaccination efﬁciently eliminated pre-established tumors in both models, even when vaccination occurred 9 days after tumor implantation. These data demonstrate the potential of HER-2-based vaccines as therapeutic agents for the treatment of cancers overexpressing HER-2. The Journal of Immunology, 2003, 171: 1588–1595.
INFLUENCE OF SPATIAL GRADIENT CAUSED BY A LARGE DAM ON FISH ASSEMBLAGE IN A SUBTROPICAL RESERVOIR – UPPER URUGUAY RIVER *

The objective of this work was to evaluate the influence of different environments formed in the area of influence of a reservoir lentic, transition and lotic on the composition and structure of the fish fauna. For this, collections were made with seasonal periodicity in the Itá reservoir, Upper Uruguay River, from 2001 to 2010. The results showed that the spatial gradient plays an important role in the fish assemblage structure. The lotic stretch was the place with the largest values of CPUE, both in number and biomass. As well, species with dependence on certain original fluvial conditions managed to maintain their presence in this stretch. In the lotic area, catching fish that are considered large migratory species coincided with their reproductive periods. The transition stretch presented an intermediate productivity and shared species with the two adjacent sections. However, it had greater similarity with the lentic area. The lentic and transition zones presented the more profound changes, showing an increase of opportunistic species. Within the context of a system of reservoirs in cascade, this study points out the free stretches flowing into the Itá reservoir as being priority areas for the conservation of the Upper Uruguay River region.
Comparative in-vitro bioequivalence analysis of some brands of ciprofloxacin HCl tablets marketed in Ethiopia

Peoples who are below poverty prefer to go for inexpensive products to reduce the cost of treatment and there are general psychologies that, less expensive drugs are less effective than the expensive one. There are different brands of ciprofloxacin, most commonly prescribed drug against gram-negative bacterial infections, has a wide price range. Hence, this study was conducted to compare the in-vitro bioequivalence profile of the expensive and less expensive brands of ciprofloxacin tablet dosage forms marketed in Ethiopia. Assay, weight uniformity, hardness, friability, disintegration time and dissolution tests were performed and all the four brands tested in this study meets the compendia specifications of hardness, weight uniformity, friability, disintegration time, and dissolution tests. But, hardness and disintegration time of brand A was not correlated. Brand A had disintegrated within 9.16 minutes and crushed in 118.7N force but, the other formulations were crushed at higher pressure and disintegrated in short period relative to brand A. This may be due to the difference in type and amount of additivives like binders and disintegrating agents added during manufacturing. This work revealed that the four formulations included in this study complied with the physicochemical quality parameters claimed in official compendia. But, disintegration time of bran A was statistically significant as compared to with the other brands. Although, there was statistically significant difference (p<0.05) between brand A and D in their dissolution profile, all brand included in this were fulfilled the compendia specifications for in-vitro dissolution profile. Hence, all brands included under this study are pharmaceutically and chemically equivalent based on the performed in-vitro determinations and could be used interchangeably.
COMPUTATIONAL SIMULATION OF RC BEAM-TO-COLUMN CONNECTIONS UNDER EARTHQUAKE LOADING

This study focuses on the computational simulation of RC beam-to-column connections under cyclic loads such as those encountered during earthquake loading. Three-dimensional finite element (FE) models have been developed and used to elucidate the resistance mechanisms, peak strength and ductility. Concrete response is modeled through a triaxial material model that can account for cyclic crack opening and closing, compressive strength degradation due to crushing and the increased compressive strength and ductility due to confining pressure. The effect of reinforcement slip is explicitly accounted for, through a cyclic bond-slip constitutive model. The material laws are used in analyses which can account for large deformations, loss of concrete cover and rebar buckling. The modeling scheme is validated using data from previous experimental tests. The ultimate goal of the work is to use these FE models to develop simplified and accurate analysis methods to enable the systematic performance assessment of RC frame systems; analyses by FE methods at that scale are considered impractical. A simplified analysis approach is proposed for RC connections, using the nonlinear truss analogy for reinforced concrete, wherein the connection is represented through an assemblage of horizontal, vertical and diagonal truss elements. The bondslip effect is accounted for through nonlinear zero-length elements and appropriate constitutive models are incorporated to capture the material behavior. The simplified approach is characterized by conceptual simplicity and computational efficiency, and is shown to provide accurate results for the experimental test against which it was calibrated. Graduate Student, Dept. of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 (email: chenxiw@vt.edu) Assistant Professor, Dept. of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 Professor, Dept. of Civil and Environmental Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 Staff II-Structural Engineer, Simpson Gumpertz & Heger, Inc., Waltham, MA Xing C, Koutromanos I, Leon R, Moharrami M. Computational Simulation of RC Beam-to-Column Connections Under Earthquake Loading. Proceedings of the 11 National Conference in Earthquake Engineering, Earthquake Engineering Research Institute, Los Angeles, CA. 2018. Eleventh U.S. National Conference on Earthquake Engineering Integrating Science, Engineering & Policy June 25-29, 2018 Los Angeles, California Computational Simulation of RC Beam-to-Column Connections Under Earthquake Loading C. Xing, I. Koutromanos, R. Leon and M. Moharrami
Coincidence of PTPN 22 c . 1858 CC and FCRL 3-169 CC genotypes as a biomarker of preserved residual β-cell function in children with type 1 diabetes †

Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gda nsk, Gda nsk, Poland Department of Developmental Neurology, Medical University of Gda nsk, Gda nsk, Poland Institute of Mathematics, Faculty of Mathematics, Physics and Informatics, University of Gda nsk, Gda nsk, Poland Institute of Informatics, Faculty of Mathematics, Physics and Informatics, University of Gda nsk, Gda nsk, Poland Department of Biology and Genetics, Medical University of Gda nsk, Gda nsk, Poland Laboratory of Immunology and Clinic Transplantology, University Clinical Centre of Gda nsk, Gda nsk, Poland †The study part associated with PTPN22 c.1858T>C polymorphism evaluation was awarded in the 2 edition of the InnoDoktorant scholarship contest (to M.P.) organized by the Pomorskie Voivodeship and European Union as particularly important for Pomeranian region development. ‡Preliminary results from first year of follow up were presented on Fifth Meeting of the EASD Study Group on Genetics of Diabetes (EASDSGGD) (Poster Session), 7-9 May 2015, Krakow, Poland. Funding Information: This study was supported by the Grant Number N N407 184137 (Decision Number 1841/B/P01/ 2009/37 to M. P.) and N N407 339239 (Decision Number 3392/B/P01/2010/39 to A. B.) from the Ministry of Science and Higher Education of Poland/National Science Centre of Poland.
Hot-carrier analysis on nMOS Si FinFETs with solid source doped junction

We report extensive experimental results of the Channel Hot Carrier (CHC) and Positive Bias Temperature Instability (PBTI) reliability of nMOS Si bulk-FinFETs with extension doping by PEALD Phosphorus doped Silicate Glass (PSG). Device performance improvements with PSG doping are achieved without substantial device reliability degradation even for short channel FinFETs. PSG results in better conformality and less damage in the junctions and lower Gate Induced Drain Leakage (GIDL) current than standard Phosphorous Ion Implantation process (P I/I).
A comparative study of ligature marks in cases of Hanging and strangulation autopsied at RIMS , Ranchi

Introduction :Hanging and ligature strangulation are the two forms of violent mechanical asphyxia in which ligature marks are found. Hanging is mostly suicidal while strangulation is mainly homicidal; hence differentiation between the two is necessary. Material and Method: This cross sectional study was conducted in the department of Forensic Medicine and Toxicology, Rajendra Institute of Medical Sciences (RIMS), Ranchi, Jharkhand, India, during a period of one year ranging from 1 st November 2016 to 31 st October 2017. Results: During this period, a total of 2981 cases of medico-legal autopsy were conducted, out of which 180 cases were having ligature marks (6.04%). There were 163 cases of hanging (5.47% of total 2981 cases) and 17 cases of strangulation (0.57% of total 2981 cases). Out of 180 cases, 90.56% (163) were of hanging and 9.44% (17) were of strangulation. The ligature mark in hanging was oblique in 100% cases, discontinuous in 96.93% cases and the subcutaneous tissue underneath the ligature mark was pale and dry in 100% cases. The ligature mark in strangulation was transverse in 100% cases, continuous in 100% cases and subcutaneous tissue underneath the mark was contused in 88.2% cases. Conclusion:Oblique and discontinuous ligature mark along with dry and pale subcutaneous tissue is suggestive of hanging while a transverse and continuous ligature mark with contused subcutaneous tissue is indicative of strangulation.
Motivation, Productivity Growth, and Business Financial Performance – A Scoping Review Approach to Linkages and Impact

The objectives of this research were to understand the nature of the relationship between three concepts namely, motivation, productivity, and financial performance. To answer the research questions posed, the researcher followed a scoping literature review approach to arrive at only 8 studies which are relevant to this present research. The results from this present research are that (1) the nature of the relationship between motivation, productivity and financial performance is positive. (2), the extent of the impact may not be that great as one study shows that without the inclusion of capital intensity, motivation has no relationship with productivity and financial performance. This research contributed to existing body of knowledge by identifying the nature of the relationship between motivation, productivity and financial performance which has received little attention from researchers.
TUMOR‐SPECIFIC CYTOTOXICITY OF ANTITUMOR AGENTS *

The title chosen for this paper represents an ideal rather than a reflection of the activity of anything presently available in the armamentarium of cancer chemotherapy. I propose to consider some reported occurrences of selectively toxic effects of agents on certain neoplastic cells in culture and the possibilities of applying such differential effects to a screening program. Four years ago I discussed tissue-culture assay of antitumor agents in a previous publication of The New York Academy of Sciences (Biesele, 1954). Limitations of my procedures, which involved various morphologic examinations of the effects of agents on short-term cultures of freshly explanted tissue in classic media, and of the results were pointed out. For several agents, notably 6-mercaptopurine, “pyridoxine-nitrogen mustard,” and some antifolic acids, gross damage selective to cells of mouse Sarcoma 180 in culture was not related to effectiveness of the agents against this sarcoma in vuz’vo, but a differential suppression of mitosis in the sarcoma cells, relative to embryonic mouse skin fibroblasts in culture, appeared to be so related. For such agents as a group of ethylenimines, no differential effects in gross damage or in inhibition of mitosis were noted in culture, but the toxicity to either neoplastic or embryonic cells in culture was correlated with activity against Sarcoma 180 in the mouse. I t therefore appeared desirable to stress caution in the interpretation of tissue-culture assays and to avoid extending application of the results beyond the particular combination of tumor, normal tissue, and culture conditions employed, so long as we remain unsure of the existence of a hypothetical unique difference susceptible to chemical attack between all neoplastic cells on the one hand and all normal cells on the other. Since then we have looked in more detail into the differential inhibition of mitosis in sarcoma cells relative to embryonic skin fibroblasts. Our conclusion is that this differential inhibition of mitosis in culture is not a completely reliable indicator of what will happen when the same agent is applied to the same tumor in an animal. This conclusion springs from a comparison of related agents and from comparisons of the effects of a given agent under variously changed conditions. For the first case we note that, on 24-hour exposure, 6-mercaptopurine inhibits Sarcoma-180 mitosis rather more than that of embryonic skin fibroblasts in culture, but thioguanine inhibits mitosis in these cells to about equal extents (Biesele, 1958b). Although azaserine or gamma-glutamyl hydrazide inhibit mitosis more in Sarcoma 180 cells than in fibroblasts, the reverse is true of DON over most of the tested range (Biesele, 1958a).
Seborrheic Keratosis: An Acantholytic Variant

Two elderly women with seborrheic keratoses on the abdomen are reported on because of the peculiar histologic appearance characterized by prominent acantholysis. Although the basic histologic architecture was a papillomatous acanthoma corresponding to that of seborrheic keratosis the upper portion of the lesions showed extensive acantholytic changes and dyskeratotic cells. Differentiation from seborrheic keratosis with focal acantholytic dyskeratosis, warty dyskeratoma, keratosis senilis and acantholytic squamous cell carcinoma could be made on the basis of clinical as well as histological features. Although the histogenesis is uncertain, it seems logical to propose that this is a rare variant of irritated seborrheic keratosis.
EFFECTS OF OVERECONSOLIDATION ON LIQUEFACTION STRENGTH CHARACTERISTICS OF SAND SAMPLES UNDER K 0-STRESS CONDITION

It is widely known that if sandy soil deposits are overconsolidated, their liquefaction strength increases. However, only a few studies have investigated the effects of overconsolidation by means of element tests to simulate the in-situ ground condition more correctly. In the present study, the liquefaction strength characteristics of overconsolidated sand samples were investigated under K0-stress condition using a hollow cylindrical torsional shear apparatus, based on the supposition that earthquake excitations apply to the horizontal ground. Furthermore, two methods, preloading and dewatering, were believed to simulate the stress histories of overconsolidation. Toyoura clean sand was used as a sample. The following behaviors were observed in the tests; 1) The liquefaction strength was greater in the tests under K0consolidation than under isotropic and anisotropic consolidations. 2) There is a possibility that the liquefaction strength increased more remarkably in the sandy soil deposits that were subjected to the preloading method than to the dewatering method.
Genotyping the G types of rotavirus and its clinical presentation in children under five years old with diarrhea in the government clinics in Pekanbaru, Indonesia

Aims: Rotavirus (RV) is the most important etiological agent of diarrhea in children with high morbidity and mortality, mainly in developing countries. A big number of children from one to five year old have been infected by RV, with at least one type of virus. Data show that human body can be infected repeatedly by different strains of RV. It is predicted that there exist 16 types of G genotypes of RV. This study was aimed to identify the G genotypes of RV in children with diarrhea in Pekanbaru, Indonesia. Methodology and results: This research is a cross-sectional study involving children aged zero to sixty months from January to July 2015. The stool samples were collected from diarrhea patients and the identification of RV was done by using the rapid test. The RNA isolation was performed on positive isolates. The identification of the G genotypes was performed by using a semi nested reverse transcription PCR method. The study involved 71 children with diarrhea. VP7based RV detection showed 47 positive samples (66.1%). The predominant G type of the positive results are G1, G9 and G3 namely 36.2%, 25.5% and 12.8%. The average age of the subjects was 15.3±2.3 months. The majority of the subject were females (53.6%). Most of the diarrhea feces presented in this study were neither haemorrhagic nor liquefied. The subjects in this study are also presented with co-symptoms such as fever (100.0%), gastrointestinal disorder (94.6%) and dypsnea (16.1%). Conclusion, significance and impact study: Based on this study, we conclude that the predominant G types is G1. This study was performed to identify the predominant G genotype of RV and designed the antigen-antibody based in diagnose RV.
Hypertensive crisis during a transurethral resection of the bladder: nondiagnosed bladder paraganglioma.

T ransurethral resection (TUR) of bladder tumors is a common procedure in urological surgery. Intraoperative complications are rare and, usually, related to technical performance problems or previous pathological conditions of the patient (1). Bladder paraganglioma is a rare tumor, and intraoperative detection of such a tumor has not been described. However, suspicion of this pathology determines the surgical and anesthetic management of the patient, because they play a key role in the prognosis. We report a case of nondiagnosed bladder paraganglioma in a patient undergoing TUR who suffered an intraoperative hypertensive crisis that led to the diagnosis.
A New Out-Of-Band Power Suppression Scheme by Extending Effective Cyclic-Prefix of OFDM

In this paper, extended-cyclic-prefix OFDM (ECP-OFDM) is proposed to suppress the out-of-band (OOB) power due to discontinuity of consecutive OFDM symbols. Besides that effective CP length is increased, it shows the advantages of low implement complexity and good OOB suppression performance.
Developments in drug delivery of bioactive alkaloids derived from traditional Chinese medicine

Abstract The bioactive alkaloids (e.g. vincristine, hydroxycamptothecin, ligustrazine, and so on) from traditional Chinese medicine (TCM) have exerted potent efficacies (e.g. anti-tumor, anti-inflammation, immunosuppression, etc.). However, a series of undesirable physicochemical properties (like low solubility and weak stability) and baneful pharmacokinetic (PK) profiles (e.g. low bioavailability, short half time, rapid clearance, etc.) have severely restricted their applications in clinic. In addition, some side effects (like cumulative toxicities caused by high-frequency administration and their own toxicities) have recently been reported and also confined their clinical uses. Therefore, developments in drug delivery of such alkaloids are of significance in improving their drug-like properties and, thus, treatment efficiencies in clinic. Strategies, including (i) specific delivery via liposomes; (ii) sustained delivery via nanoparticles, gels, and emulsions; and (iii) transdermal delivery via ethosomes, solid lipid nanoparticles, and penetrating enhancers, have been reported to improve the pharmacokinetic and physicochemical characters of problematic TCM alkaloids, decline their adverse effects, and thus, boost their curative efficacies. In this review, the recent reports in this field were comprehensively summarized with the aim of providing an informative reference for relevant readers.
Is It Necessary to Measure T4 In Screening of Congenital Hypothyroidism in Preterm Infants?

Introduction: Immaturity of hypothalamus-pituitary-thyroid axis in preterm infants causes the low level of thyroxin hormone and hypothyroxinemia of prematurity (HOP). In our country, Iran TSH that is measured by filter paper is the only laboratory test for screening of hypothyroidism and the missing of the HOP is concerning. This research was done to evaluate the rate of HOP. Material and Methods: This prospective-descriptive study was conducted in 2017 in our hospital. In the participants included preterm infants with gestational age ≤34 weeks or birth weights ≤2000 grams, measurement of TSH and T4 were done by blood sampling instead of filter paper and the values of thyroid function tests were analyzed. Results: low levels of T4 were observed ( 14.2% related to HOP and 10.3% belonged to hypothyroidism). In comparisons the values of T4 in both of sampling: in 24 cases (11.8%) persistent hypothyroxinemia ,26(12.8%) delayed hypothyroxinemia and in 29(14.2%) transient forms of hypothyroxinemia were detected. Conclusion: Our research resulted that the rate of HOP is remarkable and measurement of T4 in the screening of preterm infants is recommended.