Miracle-dz/UniFAR-FTUs huggingface dataset:
Mechanisms of action and resistance to anti-angiogenic small-molecule tyrosine kinase inhibitors in preclinical breast cancer and pancreatic neuroendocrine tumor mouse models

„Cancer“ – this one term is used to name a large spectrum of different syndromes, ranging from the relatively indolent chronic lymphocytic leukemia to highly lethal cancer types such as glioblastoma multiforme with a median survival of about 15 months even when treated with upfront treatment schedules. Based on the notion that tumors critically rely on their own blood supply, targeting the tumor blood vasculature by anti-angiogenic therapeutics has been implemented as an important treatment modality for certain cancer types. Pancreatic neuroendocrine tumors (PNETs) are rare but represent a deadly disease when detected at a metastatic stage. Importantly, PNETs have proven to respond especially well to the anti-angiogenic compound sunitinib – however, not without a significant amount of side effects. To increase the treatment options for PNET patients, we performed a preclinical evaluation of nintedanib, a small-molecule anti-angiogenic tyrosine kinase inhibitor (TKI), in the Rip1Tag2 PNET mouse model. Our work revealed that nintedanib exerted a strong anti-angiogenic and thus anti-tumor effect translating into improved animal survival. Based on our data we therefore suggest the clinical evaluation of nintedanib as a new treatment modality in PNET patient care. In contrast, numerous large clinical trials in breast cancer patients treated with compounds targeting tumor angiogenesis only resulted in improved progression-free survival (PFS) at best, without increasing overall survival (OS). This observation suggests the rapid establishment of therapy resistance. We therefore set out to investigate mechanisms of resistance to nintedanib and sunitinib in a murine syngeneic transplantation model of breast cancer. Similar to the clinical observations, targeting tumor angiogenesis in this mouse model resulted in the rapid development of resistance. Interestingly however, tumor re-growth was occurring despite a sustained reduction of the number of tumor blood vessels (i.e. microvessel density; MVD) and increased hypoxia. Mechanistically, this tumor re-growth was enabled by the upregulation of glycolysis and the establishment of a metabolic symbiosis between hypoxic and normoxic tumor areas. Interestingly, similar mechanisms might be also responsible for re-growing tumors occasionally observed in nintedanib-treated Rip1Tag2 mice. Taken together, our data provide a preclinical basis for the evaluation of nintedanib as a new treatment modality for PNET patients. Furthermore, we describe the upregulation of glycolysis as a mechanism how tumor cells can escape the action of anti-angiogenic therapies allowing them to survive and proliferate in a detrimental environment of low oxygen tension, acidic pH and nutrient deprivation.
Hubungan asupan zat gizi (energi, protein, besi dan seng), stunting dan stimulasi psikososial dengan status motorik anak usia 3-6 Tahun di paud wilayah Binaan Puskesmas Kecamatan Kebayoran Lama Tahun 2014

The results of the Ministry of Health survey in 2008 approximately 19% of infants known to impaired motor development, but spreading in every province does not yet have definitive data. And based on the preliminary study of 30 children randomly assigned in early childhood target area of Kebayoran Lama sub-district health centers in 2014 psychosocial stimulation given to the child's parents earned 36% less (11 children) and sufficient (15 children) while nutritional status based on H/A obtained 40% (12 children) with stunting category. This study aims to determine the relationship of the nutrient intake of energy, protein, iron (Fe), zinc (Zn), stunting and psychosocial stimulation of the motor status of children aged 3-6 years in the early childhood area of Kebayoran Lama sub-district health center built in 2014. The study was conducted with cross-sectional design, data retrieval way to fill out a questionnaire. This research was conducted in the early childhood area of Kebayoran Lama sub-district health centers built by the number of samples are 85 people. A total of 30.6% of respondents have impaired fine motor status and 42.4% have impaired gross motor status, 63.5% less energy intake, 60% have less protein intake, 38, 8% have less iron intake, 52.9% have less zinc intake. A total of 57.6% respondents had a short stature (stunting) and 9.4% received good stimulation and 22.4% received less stimulation from their family. We can conclude variables related to the status of gross and fine motor include intake (energy, protein and iron), stunting and psychosocial stimulation, while variables not related to the status of gross and fine motor is the intake of zinc. Therefore, from the health centers target area Kebayoran Lama sub-district health centers, early childhood education and the parents or care giver should be able to cooperate well in improving the intake and nutritional status of the
Effect of residual vanadyl ions on the spectroscopic analysis of humic acids: a multivariate approach

E. H. NOVOTNY , H. KNICKER , L. MARTIN-NETO , R. B. V. AZEREDO & M. H. B. HAYES Embrapa Solos, Rua Jardim Botânico, 1024, CEP 22460-000, Rio de Janeiro, RJ, Brazil, Chemical and Environmental Sciences, University of Limerick, Limerick, Ireland, Lehrstuhl für Bodenkunde, Technische Universität München, 85350 Freising-Weihenstephan, Germany, Embrapa Instrumentac xão Agropecuária, Rua XV de Novembro, 1452, CEP 13560-970, São Carlos, SP, Brazil, and Instituto de Quı́mica, Universidade Federal Fluminense, Outeiro de São João Batista, s/n°, Campus do Valonguinho, CEP 24020-150, Niterói, RJ, Brazil
Warfarin-Capped Gold Nanoparticles: Synthesis, Cytotoxicity, and Cellular Uptake

Currently, research studies on nanoparticle cytotoxicity, uptake or internalization into the body’s cells are of great interest for the improvement of diagnostic and therapeutic applications. We report here the synthesis and characterization of very stable novel warfarin-capped gold nanoparticles with an average diameter of 54 ± 10 nm which were prepared using sodium warfarin as a reducing agent. The nanoparticles were tested in terms of cytotoxicity and cellular internalization in vitro on two cell lines: normal lung fibroblast HFL-1 and human retinal pigment epithelial D407 cells. Our results showed that the normal lung fibroblast HFL-1 cells were more sensitive to the nanoparticle treatment compared to the human retinal pigment epithelial D407 cells. Moreover, any signs of potential cytotoxicity occurred during the first 24 h of treatment, the cellular viability remaining largely unchanged for longer exposure times. Transmission electron microscopy and dark field hyperspectral imaging revealed that the nanoparticles were effectively delivered and released to the HFL-1 and D407 cells’ cytoplasm. Our results provide valuable information to further investigate sodium warfarin-capped gold nanoparticles for possible biological applications.
ÚFAL-Oslo at MRP 2019: Garage Sale Semantic Parsing

This paper describes the ÚFAL--Oslo system submission to the shared task on Cross-Framework Meaning Representation Parsing (MRP, Oepen et al. 2019). The submission is based on several third-party parsers. Within the official shared task results, the submission ranked 11th out of 13 participating systems.
Series WP-09-08 Public Sector Performance Measurement and Stakeholder Support

Over the past several decades there has been dramatically increased attention paid to measuring the performance of public sector and nonprofit organizations in the United States and elsewhere. Recent research has indicated that public sector and nonprofit organizations are responsive to performance measurement in both productive and unproductive ways. However, it is not yet known how stakeholders respond to this measurement. This paper makes use of a unique panel survey data set of the population of elementary and middle schools in Florida to directly investigate this question. The authors exploit the fact that Florida changed its school grading system in 2002, and they study the degree to which private contributions to schools are responsive to the information contained in school grades. They find evidence that school grades can have substantial effects on a school's ability to obtain private contributions. They also observe that schools serving different clienteles are treated differently in response to changes in school grades. The survey data used in this paper were collected with funding from the National Institutes of Child Health and Human Development, U.S. Department of Education, the Annie E. Casey, Smith Richardson and Spencer Foundations, and the Atlantic Philanthropic Society. The survey data were collected in conjunction with Cecilia Rouse, Dan Goldhaber and Jane Hannaway. We have benefitted from the suggestions made by the two referees, as well as seminar participants at Northwestern University and conference participants at the American Education Finance Association and Southern Economic Association annual meetings. We alone are responsible for all errors.
COMPARISION BETWEEN BETHESDA SYSTEM AND CONVENTIONAL SYSTEM IN THYROID CYTOPATHOLOGY

Fineneedle aspirationcytology(FNAC)iswidelyused for the diagnosis of thyroid lesions.Bethesdasystemforreportingthyroidcytopathology(BSRTC)was introducedtostreamlinethereportingofthyroidaspirates.Weaimedtoevaluatethediseasespectrumofthyroid cytopathologyandcorrelationofBSRTCwith the conventionalcytopathology method and final histopathology. A Total of 110 patients who presented with thyroid swelling were evaluated by Bethesda and conventional cytopathology methods, histopathological examination and statistical analysis was done. The Bethesda method was found to be more superior. Sensitivity of Bethesda system was significantly high (95%) as compared to conventional system (75%). Specificity of Bethesda system was also significantly high (78.9%) as compared to conventional system (74.4%).
Impact of Guided Writing Strategy on Junior Secondary School Students Writing Competence in Kaduna State, Nigeria

This study investigated the impact of guided writing strategy on junior secondary school students writing competence in Kaduna State, Nigeria. Two research questions and two hypotheses were formulated for the study. The research design utilized is the quasi experimental involving pretest and posttest group design. The design had two groups; one experimental and the other control. Two public junior secondary schools were selected purposively from Zaria Educational Zone and a sample of 152 (82 male and 70 female) students in two intact classes per school were selected for the study. The instrument used was the Guided Essay Achievement Test (GEAT). The test-retest reliability method was used on GEAT; a coefficient r = 0.83 was obtained when it was analyzed by the Pearson Product Moment Correlation (PPMC). The research question was answered by the statistical mean and standard deviation of scores while the hypotheses were analyzed by the t-test statistics at 0.05 level of significance by the aid of Statistical Packages for Social Sciences (SPSS). The study revealed a significant difference in the mean achievement score in favour of the experimental group who had a higher score. Also, the difference between the mean achievement score of male and female students was not significant. It is recommended that teachers and parents should adopt the guided writing strategy in the teaching of writing in Junior Secondary Schools irrespective of gender and ability of students.
1939 A NEW ANCHITHERITNE HORSE FROM THE TUNG GUR A NEW ANCHITHERIINE HORSE FROM THE TUNG GUR FORMATION OF MONGOLIA 1 BY

INTRODUCTION The purpose of this paper is to describe a new anchitheriine horse, found in the Tung Gur beds of Mongolia by the Central Asiatic Expedition of 1930, to compare it with related forms in Eurasia and North Ainerica, and finally to discuss the significance of this fossil in the Tung Gur formation. This last point is of considerable importance, not only because of its bearing on the distribution of the anchitheriine horses throughout the northern hemisphere, but also because of its significance as to the correlative relationships of the Tung Gur horizon. The illustrationis for this paper were made by Mr. John C. Germann.
Meloda, métrica para evaluar la reutilización de datos abiertos

Current policies demanding an increase in transparency, open government and smart cities share open data publication as one of their basic pillars. However, there is a limited availability of mechanisms to assess the use and value of this information. The goal of this paper is to present a new metric, Meloda , that qualifies the information and helps to assess its reusability. Meloda ’s four dimensions are described: technical standards, access, legal considerations, and data model. Finally Meloda ’s assessment process is explained.
Discussion Paper No. 731 COMPLEMENTARY RELATIONSHIPS BETWEEN EDUCATION AND INNOVATION

This paper combines two prototype endogenous growth models: the Schumpeterian endogenous growth model developed by [Howitt(1999)] and human capital growth models developed by [Uzawa(1965)] [Lucas(1988)]. While standard Schumpeterian growth models suggest that a subsidy to R&D has long-run effects, we show that a subsidy to human capital investment has a positive impact on R&D efforts as well as on human capital accumulation. Because in our model, the per capita output growth rate depends on both technology improvements and human capital accumulation, the model bridges the gap between the literature concerning Schumpeterian growth model and that concerning growth empirics. JEL classification: O11; O31; O41
The Dynamics of the Genotype-Phenotype Association1

The integrity of an organism is maintained by networks of interacting genes. Such networks predict that genetic variants affect phenotypes in a nonadditive fashion. That is, the effect of an allelic variation in one gene is dependent on the variations in other genes. We summarize the analyses of a series of genes in a White Leghorn strain that support the existence of such gene networks: 1) genes are pleiotropic, 2) genes affect trait correlations, 3) genes affect trait distributions in a nonadditive fashion, 4) genes interact with each other, and 5) genes are at linkage disequilibrium, even when located on different chromosomes. The latter observation indicated (
A retrospective comparison study of Aboriginal and Torres Strait Islander injecting drug users and their contact with youth detention and/or prison

Doolan I1, Prof Najman J2, Henderson S3, Dr Cherney A4, Dr Plotnikova M5, Dr Ward J6, Kemp R5, Dev A5, Smirnov A5. (2015) 1Mental Health Alcohol Tobacco & Other Drugs Service, Brisbane, Queensland 2 Schools of Public Health and Social Science, University of Queensland 3 Australian Commission on Safety and Quality in Health Care 4 School of Social Science, University of Queensland 5 School of Public Health, University of Queensland 6 South Australian Health and Medical Research Institute Adelaide Corresponding author: Prof Jake M Najman PhD FASSA, Schools of Public Health and Social Science, University of Queensland, Brisbane Qld 4072, ph: (07) 3365 5189 Vol 15 No 3, July – September 2015
Molecular Dissection of the Cellular Reponse to Dengue Virus Infection

The immune response to viral infection involves a complexity of both innate and adaptive pathways at the cellular and the molecular level. There are many approaches to begin to define the pathways at work to control viral pathogenesis. The approach favored in this thesis was to conduct a broad screen of the innate immune response at the gene expression level of infected cells. The innate immune response is critical to the control of viral infections. Type I interferons (IFN), IFNα and IFNβ, are antiviral proteins that are an integral part of the innate immune response. Furthermore, by virtue of their effects on maturation and activation of antigen-presenting cells, IFNs are a pivotal link between the innate and adaptive immune systems. Most cell types produce type-I IFN when exposed to viruses. However, viruses have evolved multiple strategies to suppress IFN production or signaling. It is imperative to understand the virus-host interaction at the molecular level in order to identify as yet unknown mechanisms of the host antiviral response; these additional pathways may be useful in counteracting the viral suppression of IFN. Type-I IFNs regulate expression of at least five hundred genes, suggesting a complex network of signaling pathways. Depending on the cell type different proteins regulate the induction of IFN or the expression of IFN-inducible genes. Identification of proteins that induce selected IFN-inducible genes may provide synergistic activity with or may have an advantage over type-I IFN for anti-viral therapy in the future. Many diseases are untreatable if identified late in their progression. In resource-limited countries, many diseases are diagnosed clinically, which can lead to incorrect or delayed diagnosis and treatment. The identification of biomarkers of disease has the potential to guide the correct therapy in a timely fashion. The objective of this thesis was to identify novel anti-viral therapies and disease biomarkers for dengue virus (DENV) infection. DENV is a mosquito-borne positive-sense single-stranded RNA virus, which causes an estimated 50 million infections annually. Most DENV infections result in a febrile illness called Dengue fever (DF). Less frequently, infections cause Dengue hemorrhagic fever (DHF), a potentially fatal vascular leakage syndrome associated with the production of pro-inflammatory cytokines. At present patients infected with DENV can only be treated by intravenous fluid support to prevent hypovolemia and hypotensive shock. This treatment is less effective in severe cases if the diagnosis is delayed. Identification of therapeutics with both antiviral and immune-modulatory activity may lower patient mortality and reduce the burden of DENV on society. DENV infection is cleared in most individuals after a short period of viremia {Libraty, 20022225}. Based on in vitro and mouse models, type-I and type-II IFN signaling pathways are thought to be critical in the regulation of DENV infection. Higher serum levels of type I and type II IFNs…
Determinants of Aggregate Income-Tax-Evasion Behavior: The Case of the US''

Edgar Feige (1994, p. 119) has observed that "Federal Reserve surveys [ . ] of currency usage by American households determined that adult U.S. residents admit to holding only 12% of the nation's currency in circulation outside the banking system". Feige further observes that "Allowing for U.S. business holdings of currency, the whereabouts of perhaps 80% of the nation's [US] currency supply is presently unknown". He proceeds to conclude that "Our inability to identify the holders and location of a large fraction of the U.S. currency stock gives rise to a $240 billion problem of 'missing money"'. It is hypothesized by Feige (1994, pp. 119 and 121) as well as by others that this missing currency is a critical component of the so-called "underground economy", both in the US and in other nations. There is a highly developed literature dealing with issues surrounding the size of the underground economy and tax evasion behavior. First, there are a variety of principally theoretical models of tax evasion behavior (Falkinger 1988; Allingham and Sandmo 1972; Klepper, Nagin and Spurr 1991; Das-Gupta 1994; Pestieau, Possen and Slutsky 1994). In addition, there are a number of studies of taxevasion behavior using a) questionnaires or experiments (Spicer and Lundstedt 1976; Friedland 1982; Spicer and Thomas 1982; Benjamini
Determinants of patient satisfaction with physician interaction: a cross-sectional survey at the Obafemi Awolowo University Health Centre, Ile-Ife, Nigeria

Abstract Background: Patient satisfaction influences the outcomes of the physician-patient encounter. Patient satisfaction has become a significant health care outcome and a useful indicator of the quality of care. The aim of the study was to assess the level of satisfaction among Obafemi Awolowo University Health Centre attendees in relation to physician-patient interaction and ascertain the relationship between the different aspects of physician-patient interaction, patient satisfaction and adherence intent. Methods: Demographic information and information on patients' feelings about their doctors was collected from 300 consenting patients in a cross-sectional survey, using an adapted Medical Interview Satisfaction Scale self-administered questionnaire. Data were analysed with SPSS version 11. Logistic regression was conducted to identify the factors predicting patient satisfaction and adherence intent. Results: Of the 300 patients studied, 63.3% were generally satisfied with their physician-patient interaction. Nineteen per cent of patients were uncertain of their level of satisfaction. Patient satisfaction was positively associated with adherence intent. Patient confidence in the doctor and good communication skills and information provision on the part of the doctor predicted patient satisfaction, while patient confidence in the doctor and information provision by the doctor predicted adherence intent. Conclusions: A fifth of the study subjects were dissatisfied with their doctor-patient relationship. This study suggests the need for primary care physicians to be aware of the important place of interpersonal skills development in the application of medical knowledge and expertise in the provision of health care.
CHAPTER – 8 Optimization of BPNN ( OBPNN ) 8 . 1

Chapter 3 is focused on Back Propagation Neural Network (BPNN) and its parameters. This chapter addresses the need for optimization of parameters and a model to optimize them. To achieve the objective, we surveyed various literatures and noted various possible methods to set values of each parameter. As per the optimization model discussed in this chapter, each of these possible methods had been implemented on 3 Variable XOR problem and few best methods for each parameter had been selected. For selection of the best method, each of these best methods was tested on KDD CUP 1999 dataset. By comparing the results of various best methods, optimum value for each parameter were selected. More detail about the optimization model is available in our previous work [1].
Adoption of Retrospective Medicare Maximization Programs by State Medicaid Home Care Programs

In this article, the authors report findings from the first national study of so-called Medicare maximization billing practices for home care services, whereby states attempt to transfer home care costs from Medicaid to Medicare. The analysis indicated that seven states recovered as much as $265 million from Medicare the 1990s. The authors conclude that, while retrospective billing practices may aid states in reducing Medicaid outlays and potentially help dual Medicare beneficiaries gain coverage for their home care, these practices increased Medicare home care expenditures. The findings highlight the need for reforming our national long-term care financing policy. (Anderson, Wayne, Genevieve Kenney, and Donna Rabiner. October 2003. Adoption of Retrospective Medicare Maximization Programs by State Medicaid Home Care Programs. Journal of Health Politics, Policy, and Law 28(5): 859-881. )
The effect of continuous moderate intensity exercise training combined with high intensity interval training on cardiovascular disease risk factors

i Acknowledgements . ii List of Tables . vi List of Figures . vii List of Appendices . viii List of Abbreviations . ix Chapter 1. The Problem . 1 1.