Miracle-dz/UniFAR-FTUs huggingface dataset:
[Consumption, dietary habits and nutritional status of the Reus (IX) population. Evolution of food consumption, energy and nutrient intake and relationship with the socioeconomic and cultural level, 1983-1993].

BACKGROUND Mediterranean diet (a greater intake of olive oil, cereals, legumes, fruits and vegetables), is related to a lower prevalence of some associated diseases. The aim of the study was to observe in a Spanish population the evolution of dietary intake, whether there could be changes in the contribution of different kinds of food in energy intake, and the importance of socioeconomic and cultural factors which could influence this phenomenon. METHODS Dietary intake was evaluated using the 24 hours recall method in a representative sample (n = 941, age range = 10-69) of a Reus population (Spain). This longitudinal study consisted of 70% of the sample studied in 1983 using identical methodology. RESULTS From 1983 to 1993, we observed a significant increment of lactic derivatives (50.0%), vegetables (12.5%) and fruit intake (10.6%), and a significant decrease in tubercles (-56%), eggs (-15.6%), sugars (-13.0%), milk (-9.2%), and cereal (-7.6%) intake. Meat, fish, and visible fat intake remained unchanged. The intake of the 9 groups of food was different for men and women along this time period. We observed an increment in animal sources to our diet, primarily because of an increment in lactic derivative intake and a decrease in tubercles intake. Differences observed in 1983 between social classes related to different kinds of nutrients had nearly disappeared in 1993. Medium and high social classes followed very similar diets. However, the group of population with lowest socioeconomic status had a lower intake of energy and nutrients. CONCLUSIONS Our diet consisted of the main characteristics of the typical mediterranean diet, although we observed a decrease in cereal intake and an increase in food of animal origin. Differences observed in 1983 related to dietary habits and nutritional profile between medium and high social classes, disappeared in 1993. However, there exists a small group of people of low social class which had a lower intake of energy and other nutrients.
Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia

In chronic lymphocytic leukemia (CLL), inhibition of spontaneous apoptosis determines a worse prognosis and increasing evidences show that disease progression relies also upon cycling CLL cells. We investigated bcl-2, as measure of apoptosis, and CD71, as measure of proliferation, by flow cytometry in 265 patients with CLL. Combining bcl-2 with CD71 values, we defined three subgroups: (1) bcl2 − CD71−; (2) bcl2 + CD71+; and (3) bcl2 + CD71− or bcl2− CD71+. Both a shorter progression-free survival (PFS) and overall survival (OS) were observed in ZAP-70+ (p < 0.00001) and in patients with bcl2 + CD71+ (p < 0.00001 and p = 0.02). The patients with discordant in bcl2 + CD71− and bcl2− CD71+ showed an intermediate outcome. Noteworthy, patients with bcl2 + CD71+ showed a shorter PFS within ZAP-70 negative subgroup (p = 0.00009). In multivariate analysis of PFS, age (p = 0.005), beta-2 microglobulin (B2-M) (p = 0.003), bcl-2 (p = 0.004), CD49d (p = 0.001), and ZAP-70 (p < 0.001) resulted to be significant prognostic factors. The independent prognostic significance of B2-M (p = 0.009) and bcl-2 (p = 0.03) was confirmed within ZAP-70 negative patients. Bcl-2 and CD71 can be considered as interesting progression indicators, which should be validated in an independent cohort of patients, to take timely therapeutic decisions in CLL.
Building up financial flexibility

We ask how firms should build up financial flexibility by optimally preserving "debt capacity" or "equity capacity" through initially choosing high or low target leverage. This depends on whether additional financing is raised at competitive terms or whether there is a lock-in with initial investors, as then there will be a problem of either overinvestment or underinvestment. Firms’ initial (or target) capital structure matters as it aspects the "outside option" of both insiders and outside investors, creating countervailing incentives when new financing is raised under asymmetric information. Our theory also entails implications for start-up and venture capital financing.
Nutritional status and anthropometric measurements of patients with multiple sclerosis.

OBJECTIVE To determine the nutritional status and anthropometric measurements of patients with multiple sclerosis (MS). METHODS This research was conducted on 37 (15 men, 22 women) new diagnosed MS patients who applied to Ankara Numune Education and Research Hospital, Ankara Turkey, from June to August 2011. The nutritional status of patients was determined by a 3-day and 24-hour dietary record and a food frequency questionnaire. Body composition was analyzed by bioelectrical impedance analyzer, and body mass index was calculated. The Nutrient Data Base (BEBIS) program was used to evaluate the energy and nutrient intakes of patients and compared with Dietary Reference Intakes recommendations. Blood samples were collected and serum glucose, lipid profiles, total protein, albumin, total calcium, magnesium, vitamin B12, and vitamin D levels were analyzed. RESULTS Approximately 5.4% of patients were underweight, 54.1% were normal weight, 24.3% were overweight and 16.2% were obese. Daily mean energy intakes were 2730+/-840.97 kcal in men and 1967+/-647.24 kcal in women. The percentage of the carbohydrates was 46.9%, proteins was 14.6%, and fats of the total energy was 38.4%. Approximately 16.7% of the patients' serum vitamin D, and 6.7% of the patients' serum vitamin B12 levels were below than the reference ranges. CONCLUSION Multiple sclerosis patients have high body mass index values and poor nutritional status. It was verified that life style modification with adequate and balanced nutritional habits is very important in MS patients.
Tryptophan as the fingerprint for distinguishing aggressiveness among breast cancer cell lines using native fluorescence spectroscopy

Abstract. Tryptophan is investigated as the key native marker in cells to determine the level of metastasis competence in breast cell lines using native fluorescence spectroscopy. The ratio of fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. We found that the fluorescence of aggressive breast cancer cell has a much higher contribution from tryptophan compared with that from the normal cells and nonaggressive breast cancer cell.
Analyzing Binary Outcome Data with Small Clusters: A Simulation Study

Binary outcome data with small clusters often arise in medical studies and the size of clusters might be informative of the outcome. The authors conducted a simulation study to examine the performance of a range of statistical methods. The simulation results showed that all methods performed mostly comparable in the estimation of covariate effects. However, the standard logistic regression approach that ignores the clustering encountered an undercoverage problem when the degree of clustering was nontrivial. The performance of random-effects logistic regression approach tended to be affected by low disease prevalence, relatively small cluster size, or informative cluster size.
Experimental evidence for early nutritional programming of later health in animals

Purpose of reviewThe developmental origins of adult disease represent a burgeoning area of research for which it has been suggested that up to 50% of the current incidence of later adult disease may be explained or even alleviated. Therefore, it is not surprising that there has been a substantial increase in the number of publications on this subject. In this review, some of the most important recent publications will be highlighted, particularly those focusing on the consequences for later cardiovascular control and obesity. Recent findingsThe review will consider the extent to which both increased and decreased maternal nutrient intake in relevant animal models can result in offspring that are at greater risk of later disease, and will indicate the potential mechanisms involved. Particular focus will be given to effects on glucocorticoids, potential epigenetic effects, and the extent to which male or female offspring may be differentially programmed. In addition, the potential for nutritional or endocrine interventions during lactation in order to overcome these adverse outcomes will be covered. SummaryInappropriate growth during pregnancy, lactation and/or childhood can result in individuals whose risk of later cardiovascular disease is greatly increased. By considering the critical importance of the maternal diet from before conception through to lactation, there is a clear potential to substantially improve the health of all children and adults.
Osteogenic Differentiation of Human Mesenchymal Stromal Cells on Surface-Modified Titanium Alloys for Orthopedic and Dental Implants

Purpose Surface properties of titanium alloys, used for orthopedic and dental applications, are known to affect implant interactions with host tissues. Osteointegration, bone growth and remodeling in the area surrounding the implants can be implemented by specific biomimetic treatments; these allow the preparation of micro/nanostructured titanium surfaces with a thickened oxide layer, doped with calcium and phosphorus ions. We have challenged these experimental titanium alloys with primary human bone marrow stromal cells to compare the osteogenic differentiation outcomes of the cells once they are seeded onto the modified surfaces, thus simulating a prosthetic device-biological interface of clinical relevance. Methods A specific anodic spark discharge was the biomimetic treatment of choice, providing experimental titanium disks treated with different alkali etching approaches. The disks, checked by electron microscopy and spectroscopy, were subsequently used as substrates for the proliferation and osteogenic differentiation of human cells. Expression of markers of the osteogenic lineage was assessed by means of qualitative and quantitative PCR, by cytochemistry, immunohistochemistry Western blot and matrix metalloprotease activity analyses. Results Metal surfaces were initially less permissive for cell growth. Untreated control substrates were less efficient in sustaining mineralized matrix deposition upon osteogenic induction of the cells. Interestingly, bone sialo protein and matrix metalloprotease 2 levels were enhanced on experimental metals compared to control surfaces, particularly for titanium oxide coatings etched with KOH. Discussion As a whole, the KOH-modification of titanium surfaces seems to allow the best osteogenic differentiation of human mesenchymal stromal cells, representing a possible plus for future clinical prosthetic applications.
Discriminating English Word Senses Using Cluster Analysis

Recently, statistical models for the identification of word senses in English text have been suggested, such as Latent Semantic Analysis (LSA), which is based on dimensionality reduction. While this approach has yielded promising results, it makes many assumptions about the underlying semantic structure. In this paper, the goal is to use cluster analysis to group word senses objectively on the basis of their co-occurrence with other words. This method does not make any a priori assumptions about the group to which a case might be assigned: It is an arbitrary classification made on the basis of a specific number of a group, which are then classified on the basis of their metric distance from one another in a high-dimensional space. The results of classifying two senses of the word BANK indicate high classification accuracy for primary word senses, but poor classification accuracy for secondary word senses. A role for using cluster analysis to determine highly discriminating items in text is discussed.
PROTECT: Container Process Isolation Using System Call Interception

Virtualization is the underpinning technology enabling cloud computing service provisioning, and container-based virtualization provides an efficient sharing of the underlying host kernel libraries amongst multiple guests. While there has been research on protecting the host against compromise by malicious guests, research on protecting the guests against a compromised host is limited. In this paper, we present an access control solution which prevents the host from gaining access into the guest containers and their data. Using system call interception together with the built-in AppArmor mandatory access control (MAC) approach the solution protects guest containers from a malicious host attempting to compromise the integrity of data stored therein. Evaluation of results have shown that it can effectively prevent hostile access from host to guest containers while ensuring minimal performance overhead.
A Phase 2 study of combination therapy with arsenic trioxide and gemtuzumab ozogamicin in patients with myelodysplastic syndromes or secondary acute myeloid leukemia

Higher‐risk myelodysplastic syndromes (MDS) are similar pathobiologically to acute myeloid leukemia (AML), particularly in older adults. AML therapies thus may have activity in MDS. In the current study, phase 2 study data of arsenic trioxide (ATO) and gemtuzumab ozogamicin (GO) in CD33‐positive patients with MDS and secondary AML (sAML) were presented.
SjvO2 monitoring in head-injured patients.

Jugular venous oxygen saturation (SjvO2) measures the balance between cerebral oxygen delivery and cerebral oxygen consumption. Abnormalities that increase oxygen consumption (e.g., fever or seizures) or that decrease oxygen delivery (e.g., increased ICP, hypotension, hypoxia, hypocapnia, or anemia) can decrease SjvO2. Measuring SjvO2 continuously in the ICU in 177 patients with severe head injury, jugular venous desaturation (SjvO2 < 50%) was identified at least once in 39% of the patients. Approximately half of the episodes of desaturation were due to intracranial hypertension and half were due to systemic causes. The occurrence of one or more episodes of desaturation was strongly associated with a poor outcome, suggesting that the reduction in oxygen delivery identified with the SjvO2 monitoring contributed to the neurological injury. In the operating room, jugular venous desaturation was identified in 6 of 8 patients who were monitored during emergency evacuation of a traumatic intracranial hematoma. The lowest SjvO2 observed was 28%. In all 8 cases, the SjvO2 increased, from 47 +/- 10% to 63 +/- 5% after evacuation of the hematoma. Additional data supporting the hypothesis that these secondary insults identified with the SjvO2 monitoring contribute to the patient's neurological injury come from measurement of the extracellular concentrations of lactate and excitatory amino acids in the brain using microdialysis. Lactate concentration increased from 0.9 +/- 0.3 to 2.4 +/- 0.5 mumol/L and glutamate increased from 11.5 +/- 8.5 to 55.0 +/- 10.4 mumol/L during 8 episodes of jugular venous desaturation in 7 of 22 patients monitored with microdialysis. SjvO2 identifies global reductions in cerebral oxygenation due to a variety of causes, and is useful as a monitor for secondary insults in patients with severe head injury.
Postseismic Viscoelastic Rebound

The sudden appearance of a dislocation, representing an earthquake, in an elastic layer (the lithosphere) overriding a viscoelastic half space (the asthenosphere) is followed by time-dependent surface deformation, which is very similar to in situ postseismic deformation. The spectacular postseismic deformation following the large Nankaido earthquake of 1946 yields for the asthenosphere a viscosity of 5 x 1019 poise and a 50 percent relaxation of the shear modulus. Large thrust type earthquakes may provide, in the future, a new method for exploring the rheology of the earth's upper mantle.
Relationship between length and surface area of each segment of the large intestine and the incidence of colorectal cancer

In investigating the occurrence and clinical characteristics of diseases of the large intestine, particularly tumors, the number, distribution, and incidence of the lesions were compared between segments of the large intestine. If the distribution and incidence of lesions are correlated with the length or surface area of each segment, the incidence of lesions will be the same throughout the large intestine. If the lesions are unrelated to length or surface area, the factors that affect the occurrence of lesions must be determined and will be characteristic for each segment. However, the length and surface area of each segment of the large intestine and the ratios of each to both the total length and surface area of the large intestine are not clear. In this study the length and surface area of each segment of the large intestine were measured and calculated using the barium enema technique, and the incidence rates of cancer per unit length and surface area of each segment were determined and compared.
Abnormalities of epidermal growth factor receptor in lung squamous‐cell carcinomas, adenosquamous carcinomas, and large‐cell carcinomas

Tyrosine kinase domain (TKD) gene mutations of the epidermal growth factor receptor gene (EGFR) have proven to be clinically significant in nonsmall‐cell lung cancer (NSCLC), particularly in adenocarcinoma. However, TKD mutations together with deletion mutations in the extracellular domain of EGFR (EGFRvIII) have not been fully investigated in NSCLC except for adenocarcinoma. The present study sought to gain further insight into the significance of EGFR mutations in NSCLC by focusing on nonadenocarcinoma NSCLC.
Exploring the Service and Support Needs of Families With Early-Onset Alzheimer’s Disease

Although often cast as a disease of later life, a growing number of people are being diagnosed with Alzheimer’s disease in their 50s and 60s. Early-onset Alzheimer’s disease (EOAD) poses special challenges and needs for individuals and their caregivers, such as employment and access to services. In this cross-sectional study, the researchers surveyed 81 (N = 81) family caregivers to individuals with EOAD to identify service and support usage and need. Descriptive analyses revealed that families utilized a range of formal services (eg, adult day) and informal support from family and friends. In terms of challenges and needs, participants indicated that they struggled most with employment, benefits, and financial issues. Although most caregivers felt that they were coping well, they also indicated that their needs were not well understood by service providers and the public. These findings highlight the need to better understand and respond to the specific issues surrounding EOAD.
Lupus erythematosus gyratus repens. Report of a case associated with a lung carcinoma

A 70‐year‐old male presented with a diffuse gyrate erythema with clinical and histological features suggestive of chronic lupus erythematosus. The lupus band test, however, was negative in both involved and uninvolved skin. The skin condition was finally found to be associated with a carcinoma of the lung. The features of lupus erythematosus gyratus repens and its possible relationship to underlying neoplasia are discussed.
On the ergodic secrecy capacity and secrecy outage probability of the MIMOME Rayleigh wiretap channel

In this paper, we study the multiple‐input multiple‐output multiple‐eavesdropper wiretap channel in the nonergodic and ergodic scenarios, both with stationary Rayleigh distributed fading channels. For the ergodic scenario, we derive a new closed‐form expression for the ergodic secrecy capacity with full channel state information at the transmitter (CSIT) of the main and the eavesdropper channels, allowing the covariance matrix to be time‐varying. A lower bound for the ergodic capacity with full CSIT, in which the covariance matrix is fixed for the entire transmission period is also derived. The first expression is restricted to the high signal‐to‐nose ratio (SNR) limit, with nt transmit antennas, nr receive antennas (nr≥nt) and ne=nt eavesdropper antennas (nt×nr×nt setup). The second expression is restricted to the nt×nt×nt antenna setup. For the nonergodic scenario, we derive a new closed‐form expression for the secrecy outage probability in the high SNR limit, in a 2 × nr×2 setup with nr≥2 . We are also able to calculate an upper bound for the secrecy outage probability in other antenna setups. Copyright © 2015 John Wiley & Sons, Ltd.
Cooperative Multi-Robot Sampling-Based Motion Planning with Dynamics

This paper develops an effective, cooperative, and probabilistically-complete multi-robot motion planner. The approach takes into account geometric and differential constraints imposed by the obstacles and the robot dynamics by using sampling to expand a motion tree in the composite state space of all the robots. Scalability and efficiency is achieved by using solutions to a simplified problem representation that does not take dynamics into account to guide the motion-tree expansion. The heuristic solutions are obtained by constructing roadmaps over low-dimensional configuration spaces and relying on cooperative multi-agent graph search to effectively find graph routes. Experimental results with second-order vehicle models operating in complex environments, where cooperation among the robots is required to find solutions, demonstrate significant improvements over related work.
Transcription of novel genes, including a gene linked to the mating-type locus, induced by Chlamydomonas fertilization

Six cDNA clones have been identified that are complementary to transcripts present in young zygotes of Chlamydomonas reinhardtii but absent from vegetative and gametic cells. Five early transcripts are synthesized within 5 to 10 min of fertilization; the sixth, late, transcript is not synthesized until 90 min following fertilization. Synthesis of both classes requires cell fusion between gametes. Cycloheximide fails to inhibit early mRNA synthesis, indicating that transcription factors must preexist in the gametes and be activated by cytoplasmic confluence. By contrast, cycloheximide blocks synthesis of the late transcript, suggesting that an early protein product(s) is required for expression of the late gene. Restriction fragment length polymorphism analysis of inter- and intraspecific genetic crosses demonstrates that one of the early genes is very tightly linked to the mating-type locus.