Miracle-dz/UniFAR-FTUs huggingface dataset:
A Novel Workflow for Geothermal Prospectively Mapping Weights-of-Evidence in Liaoning Province, Northeast China

Geological faults are highly developed in the eastern Liaoning Province in China, where Mesozoic granitic intrusions and Archean and Paleoproterozoic metamorphic rocks are widely distributed. Although the heat flow value in eastern Liaoning Province is generally low, the hot springs are very developed. It is obvious that the faults have significant control over the distribution of hot springs, and traditional methods of spatial data analysis such as WofE (weight of evidence) usually do not take into account the direction of the distribution of geothermal resources in the geothermal forecast process, which seriously affects the accuracy of the prediction results. To overcome the deficiency of the traditional evidence weight method, wherein it does not take the direction of evidence factor into account, this study put forward a combination of the Fry and WofE methods, Fry-WofE, based on geological observation, gravity, remote sensing, and DEM (digital elevation model) multivariate data. This study takes eastern Liaoning Province in China as an example, and the geothermal prospect was predicted respectively by the Fry-WofE and WofE methods from the statistical data on the spatial distribution of the exposed space of geothermal anomalies the surface. The result shows that the Fry-WofE method can achieve better prediction results when comparing the accuracy of these two methods. Based on the results of Fry-WofE prediction and water system extraction, 13 favorable geothermal prospect areas are delineated in eastern Liaoning Province. The Fry-WofE method is effective in study areas where the geothermal distribution area is obviously controlled by the fault. We provide not only a new method for solving the similar issue of geothermal exploration, but also a new insight into the distribution of geothermal resources in Liaoning Province.
A proteomics view on integrin‐mediated adhesions

Individual cells in multicellular organisms constantly explore their microenvironment, or niche, to obtain spatial information that is used to regulate cell behavior to maintain tissue integrity. The extracellular matrix (ECM) is an important source of such spatial information. Binding of the integrin family receptors to the ECM triggers formation of integrin adhesion complexes (IACs) that link the ECM network to cellular cytoskeleton via remarkably large multiprotein complexes collectively referred to as the integrin adhesome. Recent advances in proteomics have enabled researchers to study the IAC composition in detail. Various biochemical IAC isolation methods and culture conditions have been employed to study the composition and dynamics of integrin‐mediated adhesions mainly in fibroblasts and lymphoblasts. These studies have led to identification of daunting lists of potential IAC components. This review focuses on the current status of proteomics‐driven research seeking to understand integrin functions by comprehensive analysis of IAC components. These systems level approaches have revealed the complexity of biochemical and biomechanical signals that are processed at IACs and provide a novel insight into how these signals are conveyed to regulate cellular behavior.
Darwin and evolutionary tales in leukemia

All cancers evolve by a process of genetic diversification and “natural selection” akin to the process first described by Charles Darwin for species evolution. The evolutionary, natural history of childhood acute lymphoblastic leukemia (ALL) is almost entirely covert, clinically silent and well advanced by the point of diagnosis. It has, however, been possible to backtrack this process by molecular scrutiny of appropriate clinical samples: (i) leukemic clones in monozygotic twins that are either concordant or discordant for ALL; (ii) archived neonatal blood spots or Guthrie cards from individuals who later developed leukemia; and (iii) stored, viable cord blood cells. These studies indicate prenatal initiation of leukemia by chromosome translocation and gene fusion (or hyperdiploidy) and the post-natal acquisition of multiple, gene copy number alterations (CNAs), mostly deletions. The prenatal or first “hit” occurs very commonly, exceeding the clinical rate of ALL by some 100× and indicating a low rate of penetrance or evolutionary progression. The acquisition of the critical, secondary CNAs requires some Darwinian selective advantage to expand numbers of cells at risk, and the cytokine TGF beta is able to exercise this function. The clonal architecture of ALL has been investigated by single cell analysis with multicolor probes to mutant genes. The data reveal not a linear sequence of mutation acquisition with clonal succession but rather considerable complexity with a tree-like or branching structure of genetically distinct subclones very reminiscent of Darwin’s original 1837 evolutionary divergence diagram. This evolutionary pattern has important implications for stem cells in ALL, for the origins of relapse and for therapeutic targeting.
Benefits of moderate weight loss in patients with type 2 diabetes

Weight loss is a primary goal of therapy in overweight patients with type 2 diabetes. This review examines whether positive patient outcomes are observed even after relatively small amounts of weight loss, that is, weight loss being more easily attainable in practice. Clinical studies demonstrate that therapeutic benefit rises with increasing weight loss, but that losses as low as 0.45–4 kg (1–9 lb) have positive effects on metabolic control, cardiovascular risk factors and mortality rates. Even the intention to lose weight, without significant success, can improve outcomes in patients with diabetes, presumably because of the healthy behaviours associated with the attempt. The current data support a continued focus on weight loss, including moderate weight loss, as a key component of good care for overweight patients with type 2 diabetes.
Comparison of fatty acid profiles of edible meat, adipose tissues and muscles between cocks and capons

The effect of caponisation on fat composition by parts (wing, breast, thigh, and drumstick) and tissues (skin, subcutaneous adipose tissue, intermuscular adipose tissue and muscle) was examined in the present study and fatty acid profiles of abdominal fat and edible meat by parts and tissue components were determined. The sample was made up of twenty-eight castrated and twenty male Penedesenca Negra chicks reared under free-range conditions and slaughtered at 28 wk of age; the birds were castrated at four or eight weeks. Caponisation significantly increased (P < 0.01) the chemical fat content in all parts (16.31% to 37.98% in breast; 21.98% to 34.13% in wing; 21.09% to 49.57% in thigh; 14.33% to 24.82% in drumstick) and led to minor modifications in fat haracteristics, particularly in the thigh and the drumstick, where the unsaturated vs. saturated fatty acid ratio increased from 1.31 to 1.76 ( P < 0.01) and from 1.48 to 2.07 (P < 0.01), respectively. Delaying the age of castration from 4 to 8 weeks increased this ratio by 0.35 in the edible meat. Even though the profile of the abdominal fat is less saturated in capons, all changes occurring on fat quality after caponisation indicate that increased fatness after castration does not imply worse fat nutritional properties.
Prevalence of resistance to clarithromycin and its clinical impact on the efficacy of Helicobacter pylori eradication.

BACKGROUND Triple therapy with a proton-pump inhibitor (PPI) in combination with metronidazole and clarithromycin is the method of choice for eradication of Helicobacter pylori. Failures have been primarily blamed on the development of resistance to clarithromycin. The present study investigated the prevalence and clinical significance of resistance to clarithromycin and metronidazole in determining therapeutic success of both triple therapy as a primary eradication method and high-dose dual therapy in non-responders. METHODS On the basis of prior therapy, H. pylori-positive patients were assigned to one of two groups in the present prospective study. Group A (n = 93) included patients who had not undergone any prior eradication treatment, whereas group B (n = 15) consisted of patients who had received clarithromycin but in whom eradication had been unsuccessful. All patients underwent endoscopy with biopsy for bacterial culture and resistance studies. Patients in group A were treated with a 7-day regimen of pantoprazole (40 mg twice daily), metronidazole (500 mg twice daily), and clarithromycin (250 mg twice daily), whereas those in group B received omeprazole (40 mg three times a day) and amoxycillin (1000 mg three times a day ) for 14 days. Success of the eradication treatment was ascertained by means of the 13C urea breath test. RESULTS In group A resistance to clarithromycin and metronidazole was identified in 3 patients (4.9%) and in 14 patients (22.9%), respectively. Eradication proved successful in 78 of 84 patients (92.6%) followed up. Two of the 3 patients with primary clarithromycin resistance and 1 of the 14 patients with metronidazole resistance did not respond to treatment. In group B isolated or combined resistance to clarithromycin was found in seven patients, whereas another four showed isolated resistance to metronidazole. Eradication proved successful in 10 of 13 controlled patients (76.9%) followed up, and only 2 patients reported severe side effects. CONCLUSION Determination of antibiotic resistance before initiating therapy is not necessary, since primary resistance to clarithromycin is rare. The Italian triple therapy remains a highly effective primary therapeutic method. Further, routine determination of resistance in non-responders also seems to be superfluous because high-dose dual therapy is an effective and well-tolerated second-line therapy regardless of the patients' resistance status.
Popliteal-to-Distal Bypass: Identifying Risk Factors Associated with Limb Loss and Graft Failure

Modern therapy, including endoluminal procedures and improved medical management, still yield less than desired results for tibial vessel occlusive disease. Despite the recent focus on these newer interventions, few modern series have evaluated the efficacy of popliteal-to-distal bypass procedures. The authors aimed to determine the efficacy of popliteal-distal bypass and to identify adverse prognostic factors for ultimate limb salvage. Eighty-seven patients (54 men; average age: 63 years) underwent 92 popliteal-distal bypasses. Duplex ultrasound was utilized to assess patency of all grafts. Data were analyzed by life-table analysis to determine patency rates at postoperative intervals. Median patient follow-up was 2.4 years. Major indications for bypass included chronic limb ischemia (86%) and disabling claudication (8%); 62% of the limbs were considered threatened, and 74% of the proximal anastomoses were above-knee. All procedures were technically successful. There were no perioperative (<30 days) deaths, and 86% of patients were alive at 5 years. Cumulative patency rates were 74% at 6 months, 70% at 2 years, and 63% at 5 years. Limb salvage rates closely paralleled patency rates. At 5 years, 62% of the affected limbs were intact; 72% of the limbs lost were associated with early (<180 days) bypass failures. Predictors of limb loss included early graft failure (84 days vs 1,288 days, p <0.0001), younger age (57 years vs 64 years, p = 0.039), history of previous ipsilateral vascular procedures (50% vs 21%, p = 0.03), heavy (>1 ppd) tobacco use (p = 0.001), and a thrombosed femoral-popliteal bypass at presentation (p = 0.002). When successful, popliteal-distal bypass is associated with excellent long-term patency and limb salvage rates. Early failures are often associated with limb loss. Heavy tobacco use, younger age, early graft failures, repeat revascularization, and presentation with a thrombosed femoral-popliteal graft are associated with limb loss.
Vulvar plasmablastic lymphoma in a HIV-positive child: a novel extraoral localisation

Plasmablastic lymphoma (PBL) has been characterised by the World Health Organization as a new entity. This report describes an unusual case of PBL in a 3-year-old HIV-infected patient showing a cutaneous vulvar lesion with 9 months of evolution and prolapsed vulvovaginal mucosa. Histopathological examination of a biopsy sample showed diffuse submucosal infiltration by large cells with a cohesive growth pattern, and round and vesicular nuclei with fine chromatin centrally or eccentrically placed with one or more prominent nucleoli. Immunohistochemical staining in neoplastic cells was positive for multiple melanoma oncogene (MUM1), CD138, CD45 and epithelial membrane antigen (EMA). The diagnosis was PBL, stage III. Epstein–Barr virus (EBV) expression was positive by EBV encoded RNAs in situ hybridisation. This is believed to be the third case of paediatric HIV-associated PBL reported in the literature, and the first with vulvar localisation, which is a new anatomical location for this entity.
The Effects of Frost Heaving on Objects in Soils, II: Laboratory Experiments

Recent laboratory studies of frost heaving of artifacts in soils are relevant to archaeologists, geomorphologists, and Arctic and Alpine specialists. Investigations were undertaken to determine the susceptibility to frost heave of artifacts with differing effective heights (the vertical dimension of buried objects). To this end, wooden dowels oriented from 0 to 90 degrees from the horizontal and vertically oriented wooden parallelepipeds of different lengths were emplaced in saturated soil and alternately frozen and thawed. These studies show that differential frost heaving occurred; objects with larger angles from the horizontal and vertically oriented objects with greater lengths experience greater upward movement due to frost heaving. Moreover, in addition to being frost heaved upwards, artifacts oriented at differing angles tend to rotate towards the vertical with each freeze-thaw cycle. The significance of the results is twofold. First, statistical models generated from the data provide a quantitative assessment of the role of effective height in frost heaving of artifacts. Secondly, the results are important in modeling the mechanics of the frost heaving process because the distribution of com ponent forces may be inferred.
Traumatic brain injuries: predictive usefulness of CT.

The computed tomographic (CT) scans from 72 patients with traumatic brain injury were reviewed to determined whether a specific type, location, or size of lesion correlated with changes in neurologic function (assessed with the Glasgow Coma Scale [GCS]), patient outcome (assessed with the Glasgow Outcome Scale [GOS]), or catecholamine levels. The lesions were classified as focal or diffuse. GOS changed as a function of lesions size (P = .00004) in the 48 patients with focal hemorrhages, regardless of whether the lesions were intra- or extraaxial, and in the 19 patients with normal CT scans. Patients with lesions larger than 4,100 mm3 had a twofold greater risk of a poor outcome than patients with smaller lesions (100% vs 50%). Patients with normal CT scans were significantly more likely to have mild neurological dysfunction or none than patients with abnormal CT scans (P = .03), but lesion location, skull fracture, and pineal shift were not significant predictors of GCS or GOS scores. A positive relationship existed between lesion size and both plasma norepinephrine and epinephrine levels (P less than .02); a significant relationship existed between lesion size and GCS score (P = .02).
Chemical Variability and Biological Activities of Volatile Oils from Hyptis suaveolens (L.) Poit.

Summary Hyptis suaveolens (L.) Poit. belongs to the Lamiaceae family and is widely used in folk medicine in various countries. Th e essential oils from H. suaveolens have been extensively investigated and are mainly composed of monoterpenes and sesquiterpenes, although signifi cant diterpene content has been reported in recent studies. Th e survey of the literature concerning H. suaveolens essential oils revealed a high level of chemical variability in terms of quantity and composition that is commonly observed for volatile oils from other plant species. However, few researchers have dealt with the reasons for such chemical variability. Our research group has been investigating the relationships between growing conditions of the plants and the H. suaveolens (L.) Poit. essential oil composition. Th e results of these investigations have led to some advances in the characterization and knowledge of H. suaveolens chemotypes from Brazil. Nevertheless, since this species presents high level of genetic polymorphism and allows it to adapt to the alterations in environmental features resulting in interpopulational and intrapopulational variability in the volatile oil chemical compositions. Consequently, biochemical assays on the biosynthetic pathway are required in order to detect the molecular mechanisms involved in inducing diff erential terpenoid biosynthesis within H. suaveolens. Th ese are some of the challenges which require resolution leading to an understanding of the complex secondary metabolism of this species, thereby making possible the volatile oil chemical standardization seeking productivity and phytotherapy.
Keep your head high: skulls on stakes and cranial trauma in Mesolithic Sweden

Abstract The socio-cultural behaviour of Scandinavian Mesolithic hunter-gatherers has been difficult to understand due to the dearth of sites thus far investigated. Recent excavations at Kanaljorden in Sweden, however, have revealed disarticulated human crania intentionally placed at the bottom of a former lake. The adult crania exhibited antemortem blunt force trauma patterns differentiated by sex that were probably the result of interpersonal violence; the remains of wooden stakes were recovered inside two crania, indicating that they had been mounted. Taphonomic factors suggest that the human bodies were manipulated prior to deposition. This unique site challenges our understanding of the handling of the dead during the European Mesolithic.
Optical detection of neural function in the chick visual pathway in the early stages of embryogenesis

We investigated the developmental pattern of functional synaptogenesis in the chick visual pathway using a multiple‐site optical recording method. Responses to optic nerve stimulation were recorded from the diencephalon and mesencephalon of the chick embryo. The first excitatory postsynaptic responses to optic nerve stimulation appeared in the contralateral diencephalon at Hamburger–Hamilton stage 27, which corresponds to an incubation day 5.5 (E5.5). At more developed stages, the optical signals evoked by optic nerve stimulation spread to several different regions, including the tectum and extra‐tectal visual nuclei. We constructed maps of neural activity in the diencephalon and mesencephalon at different stages to investigate the spatio‐temporal patterns of functional development in the chick visual system. The maps revealed that distinct postsynaptic response areas in the extra‐tectal regions showed different onsets of activity, suggesting that the corresponding visual nuclei exhibit different time courses of functional synaptogenesis. We also identified the onset and location of the first functional synaptic connection in the optic tectum, which had been a point of controversy in earlier studies. In the tectal region, the action potential and the excitatory postsynaptic potential first appeared at E8, although these signals were recognized in the tecto/tegmental region at E7. The response area expanded with retinotectal fibre elongation, and reached the area centralis at E9. These results show that the onset of synaptic function in the tectum occurs 2–3 days earlier than was previously reported.
Contribution of Residues in Second Transmembrane Domain of ASIC1a Protein to Ion Selectivity*

Background: The mechanisms of ion selectivity and permeation of acid-sensing ion channels are not solved. Results: Substitutions at selected sites altered cation discrimination. Conclusion: Ion selectivity is achieved by discrimination of ions on the basis of size and by selective coordination at restricted sites in the pore of ASIC1a. Significance: Elucidating the mechanisms of ion permeation and selectivity of ASIC1a is important to understand its function and physiological role. Acid-sensing ion channels (ASICs) are proton-gated cation-selective channels expressed in the peripheral and central nervous systems. The ion permeation pathway of ASIC1a is defined by residues 426–450 in the second transmembrane (TM2) segment. The gate, formed by the intersection of the TM2 segments, localizes near the extracellular boundary of the plasma membrane. We explored the contribution to ion permeation and selectivity of residues in the TM2 segment of ASIC1a. Studies of accessibility with positively charged methanethiosulfonate reagents suggest that the permeation pathway in the open state constricts below the gate, restricting the passage to large ions. Substitution of residues in the intracellular vestibule at positions 437, 438, 443, or 446 significantly increased the permeability to K+ versus Na+. ASIC1a shows a selectivity sequence for alkali metals of Na+>Li+>K+≫Rb+>Cs+. Alanine and cysteine substitutions at position 438 increased, to different extents, the relative permeability to Li+, K+, Rb+, and Cs+. For these mutants, ion permeation was not a function of the diameter of the nonhydrated ion, suggesting that Gly-438 encompasses an ion coordination site that is essential for ion selectivity. M437C and A443C mutants showed slightly increased permeability to K+, Rb+, and Cs+, suggesting that substitutions at these positions influence ion discrimination by altering molecular sieving. Our results indicate that ion selectivity is accomplished by the contribution of multiple sites in the pore of ASIC1a.
Evidence for Physiological Response Stereotypy in Migraine Headache

&NA; Several biological theories of psychosomatic disorders predict that susceptible individuals will have stereotypic physiological responses to stress. This hypothesis was tested in a sample of 13 migraine headache subjects by observing their head and hand temperature, frontal electromyography (EMG), heart rate, skin conductance level, and finger pulse amplitude under the conditions of rest, orienting to a tone, time estimation, reaction time, and mental arithmetic. Thirteen nonheadache cohorts served as a control group. For the migraine group, analyses of variance revealed significantly warmer head and hand temperatures and lower frontal EMG. Range‐corrected data, which allow comparisons among the physiological measures, showed the migraine group to have a more stereotypic response pattern across tasks. Discriminant analyses, using both untransformed and range‐corrected data made excellent post‐dictions of group membership.
Estimating Link Reliability in Wireless Networks: An Empirical Study and Interference Modeling

Recently, it has been received in the community that the link reliability is strongly related to RSSI (or SINR) and the external interference makes it unpredictable, but the unpredictability has not been fully explained yet. In order to examine the causes of the unpredictable link state, we first configured an empirical testbed, performed a measurement study, and observed that the link reliability actually depends on an intra-frame SINR distribution. We also discovered that a RSSI (or SINR) value is not always a good indicator to estimate the link state. Based on these results, we propose a modeling framework for estimating the link state in the presence of the wireless interference. We vision that the framework can be used for developing link-aware protocols to achieve their optimal performance in a hostile wireless environment.