Miracle-dz/UniFAR-FTUs huggingface dataset:
Postural Effects on Cardiac Output and Mixed Venous Oxygen Saturation in Humans

The activation of cardiovascular reflexes for postural adaptation questions whether, in healthy humans, the central blood volume is optimised to support the upright position. A functional definition of an ‘optimal circulating volume’ that provides the heart with enough central blood volume to establish a maximal cardiac output (CO) and mixed venous oxygen saturation (Sv,O2) at rest was evaluated in nine healthy subjects. Preload to the heart was varied by passively changing the body position from 70 deg head‐up to 20 deg head‐down tilt. The Sv,O2 was compared with simultaneously measured estimates of CO by computer‐controlled thermodilution. The CO was in the range 8.7‐3.8 l min−1 and Sv,O2 was in the range 79‐58 %. Neither CO (median 6.0 (range 5.3‐8.7) l min−1) nor Sv,O2 (mean ± S.D. 73.6 ± 2.6 %) changed from the supine to the 20 deg head‐down position. During sustained 70 deg head‐up tilt, Sv,O2 decreased to 64 ± 4 % together with a decline in CO to 4.7 (3.9‐5.6) l min−1 (P < 0.05). Under conditions of varying tilt angles, a change in CO is paralleled by concordant changes in Sv,O2. Maximal values for CO and Sv,O2 during supine rest suggest that the horizontal position provides for an ‘optimal’ central blood volume.
Large carabid beetle declines in a United Kingdom monitoring network increases evidence for a widespread loss in insect biodiversity

Summary 1. Carabid beetles are important functional components of many terrestrial ecosystems. Here, we describe the first long-term, wide-scale and quantitative assessment of temporal changes in UK carabid communities, to inform nationwide management aimed at their conservation. 2. Multivariate and mixed models were used to assess temporal trends over a 15-year period, across eleven sites in the UK Environmental Change Network. Sites covered pasture, field margins, chalk downland, woodland and hedgerows in the lowlands, moorland and pasture in the uplands, and grassland, heaths and bogs in montane locations. 3. We found substantial overall declines in carabid biodiversity. Three-quarters of the species studied declined, half of which were estimated to be undergoing population reductions of > 30%, when averaged over 10-year periods. Declines of this magnitude are recognized to be of conservation concern. They are comparable to those reported for butterflies and moths and increase the evidence base showing that insects are undergoing serious and widespread biodiversity losses. 4. Overall trends masked differences between regions and habitats. Carabid population declines (10-year trend, averaged across species) were estimated to be 52% in montane sites, 31% in northern moorland sites and 28% in western pasture sites (with at least 80% of species declining in each case). Conversely, populations in our southern downland site had 10year increases of 48% on average. Overall, biodiversity was maintained in upland pasture, and populations were mostly stable in woodland and hedgerow sites. 5. Synthesis and applications. Our results highlight the need to assess trends for carabids, and probably other widespread and ubiquitous taxa, across regions and habitats to fully understand losses in biodiversity. Land management should be underpinned by a consideration of how wide-scale environmental drivers interact with habitat structure. The stability of population trends in woodlands and hedgerows of species that are declining elsewhere puts these habitats at the fore-front of integrated landscape management aimed at preserving their ecosystem services.
Provocative Test with Propofol: Experience in Patients with Cerebral Arteriovenous Malformations Who Underwent Neuroendovascular Procedures

BACKGROUND AND PURPOSE: Provocative testing before AVM embolization has been shown to be a predictor of a successful endovascular treatment without neurologic deficits. Propofol has been used previously as an alternative agent in Wada testing with adequate results. The purpose of this study was to show our experience with the use of propofol as a safe and effective alternative to barbiturate provocative testing in AVM embolization procedures. MATERIALS AND METHODS: A series of 20 patients, undergoing 38 embolization sessions, was treated for cerebral AVMs between November 2007 and February 2009 by endovascular methods. All patients were treated under conscious sedation. Pre-embolization neurologic assessment was performed with provocative testing by using propofol at 7-mg doses by an intra-arterial route after microcathether placement in or near the AVM nidus. RESULTS: Among these 20 patients, 3 developed transient neurologic deficits after provocative testing, precluding initial or further embolization. One of the patients passing the provocative test developed slight paresis as a result of embolization with n-BCA, resulting in a PPV of 97%. CONCLUSIONS: Propofol use during provocative testing in AVM embolization procedures represents an effective alternative to barbiturate testing and can have a positive impact in improving safety under sedation.
Activity of inferior temporal neurons during orientation discrimination with successively presented gratings.

1. We recorded from inferior temporal (IT) cells in three monkeys while they performed an orientation discrimination task with successively presented gratings. Histological reconstruction of two monkey brains indicated that most recordings were from TE3. The task was exactly the same as the one used in a previous V1 study, allowing direct comparison. 2. One quarter of IT cells were responsive to the grating. Response strength and variability of the cells excited by the grating (n = 341) were similar to those in V1, whereas response latency was on average 40 ms longer than in V1. 3. In one third of the responsive cells orientation had a significant effect. Sensitivity for orientation was captured by the orientation sensitivity index, which ranged from 0 to 0.95 with a median of 0.23. Orientation sensitivity of IT cells was on average much less than that of V1 cells. More cells preferred horizontal and vertical than oblique orientations. 4. The differences in responsiveness and orientation sensitivity among individual animals could be accounted for by the anterior/posterior difference in recording position. 5. Task-related behavioral effects were examined in 283 cells that were responsive to the visual stimuli. Order effects were examined in "same" trials and occurred in half of the IT cells in each of the three monkeys. In these cells there was on average a threefold difference in response between the first stimulus (S1) and the second stimulus in same trials (S2same). In two monkeys the average response to S2same was less than that to S1, whereas in the third monkey the average response to S1 was smaller than that to S2same. 6. IT cells also exhibited same/different effects, whereby response to a physically identical second stimulus differed between same and "different" trials. Generally cells responded more to the second stimulus in different trials than to S2same but the opposite also occurred. For a subset of these cells we could show that the correct/error type of the trial had no effect and that the response occurred before the saccadic response. 7. These context effects were modulations of the gain of the orientation tuning curves for the different types of responses. The tuning for orientation of these different responses was similar. 8. One third of the responsive IT cells exhibited an increased activity in the interstimulus interval (ISI), fitting the definition of delay cells. This activity was maintained when the ISI was lengthened from 300 to 800 ms. The orientation tuning of this response was similar to that for S1 responses. (ABSTRACT TRUNCATED AT 400 WORDS)
Instant‐quality fluorescence in‐situ hybridization as a new tool for HER2 testing in breast cancer: a comparative study

HER2 instant‐quality fluorescence in‐situ hybridization (IQFISH) is a new fluorescence in‐situ hybridization (FISH) assay developed with a non‐toxic buffer that reduces the hybridization time to 1–2 h, enabling a turnaround time of 3 h 30 min from dewax to counting. The aim of this study was to compare assessment of HER2 status using IQFISH and assessment using standard FISH.
Ultrastructure of Leptotrichia buccalis.

SUMMARY: Thin sections of Leptotrichia buccalis were examined with the electron microscope. The organism showed a cell-wall profile characteristic of Gramnegative bacteria. A Gram-positive homofermentative Lactobacillus sp. was included in the study for comparison. The results indicate that L. buccalis should not be included within the Lactobacillaceae.
A neighborhood vector propagation algorithm for community detection

Community detection is an important technique to understand the structure of complex social networks. Many approaches have been devised to extract community structures in recent years. In this paper we propose a novel neighborhood vector propagation algorithm (NVPA) to detect communities in a social network which has greater accuracy than algorithms in the literature. In our approach, a neighborhood vector is proposed to store the neighborhood information, and a vector propagation algorithm is designed to disseminate neighborhood information to other nodes. After neighborhood propagation, hierarchical clustering is used to find the community structure based on similarity measures. We apply our algorithm on two real-world networks and LRF benchmark networks. Experimental results show that our algorithm achieves greater accuracy than several well known algorithms in the literature.
Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications

Although CD4+/CD25+ T regulatory cells (Tregs) are a potentially powerful tool in bone marrow transplantation, a prerequisite for clinical use is a cell‐separation strategy complying with good manufacturing practice guidelines. We isolated Tregs from standard leukapheresis products using double‐negative selection (anti‐CD8 and anti‐CD19 monoclonal antibodies) followed by positive selection (anti‐CD25 monoclonal antibody). The final cell fraction (CD4+/CD25+) showed a mean purity of 93·6% ± 1·1. Recovery efficiency was 81·52% ± 7·4. The CD4+/CD25+bright cells were 28·4% ± 6·8. The CD4+/CD25+ fraction contained a mean of 51·9% ± 15·1 FoxP3 cells and a mean of 18·9% ± 11·5 CD127 cells. Increased FoxP3 and depleted CD127 mRNAs in CD4+CD25+FoxP3+ cells were in line with flow cytometric results. In Vβ spectratyping the complexity scores of CD4+/CD25+ cells and CD4+/CD25‐ cells were not significantly different, indicating that Tregs had a broad T cell receptor repertoire. The inhibition assay showed that CD4+/CD25+ cells inhibited CD4+/CD25‐ cells in a dose‐dependent manner (mean inhibition percentages: 72·4 ± 8·9 [ratio of T responder (Tresp) to Tregs, 1:2]; 60·8% ± 20·5 (ratio of Tresp to Tregs, 1:1); 25·6 ± 19·6 (ratio of Tresp to Tregs, 1:0·1)). Our study shows that negative/positive Treg selection, performed using the CliniMACS device and reagents, enriches significantly CD4+CD25+FoxP3+ cells endowed with immunosuppressive capacities. The CD4+CD25+FoxP3+ population is a source of natural Treg cells that are depleted of CD8+ and CD4+/CD25‐ reacting clones which are potentially responsible for triggering graft‐versus‐host disease (GvHD). Cells isolated by means of this approach might be used in allogeneic haematopoietic cell transplantation to facilitate engraftment and reduce the incidence and severity of GvHD without abrogating the potential graft‐versus‐tumour effect.
Greek Mental Health Nurses’ Practices and Attitudes in the Management of Acute Cases

The aim of this study was to identify nurses’ interventions, views, and attitudes concerning critical incidents. Using semi-structured interviews, a descriptive study was conducted among mental health nurses working in three major psychiatric hospitals. Analysis of nurses’ audio-recorded data indicated that they had used a number of different interventions under six main categories: counseling, performing security practices, monitoring thinking disturbances, contacting the psychiatrist on-call, contacting the chief nurse on-call, and administering medication. The need for specialized training was noticed and problems like accountability, nurse-patient interactions, and nurse-doctor relationships were considered crucial by the mental health nurses.
Helium-vacancy cluster in a single bcc iron crystal lattice

The properties of the cluster HenV, an iron vacancy with an increasing number of He atoms, is studied with molecular statics and molecular dynamics simulations. A study of the binding energy of the self-interstitial atom (SIA) and the He, shows that from n = 6 the HenV cluster is stable and cannot shrink anymore, and from n = 16 the HenV2 cluster is stabilized by the emission of SIA in the form of a ⟨110⟩ dumbbell. Calculation of the pressure exercised by the HenV cluster shows local peak normal stress and shear stress values up to 9 GPa and 4 GPa, respectively. The local configurations of HenV suggest that with increasing helium content, a high symmetry configuration close to a face centered cubic lattice is formed.
Estimates of ocular and visual retention following treatment of extra-large uveal melanomas by proton beam radiotherapy.

OBJECTIVE To assess outcomes of proton beam radiotherapy for the treatment of extra-large uveal melanomas in patients specifically referred to the University of California, San Francisco, for ocular conservation therapy. Series patients uniformly refused enucleation both at an outside institution and again as a treatment option after extensive discussion at the University of California, San Francisco. DESIGN In a retrospective, nonrandomized cohort study, 21 patients with extra-large choroidal or ciliochoroidal melanomas measuring at least 10 mm in maximum thickness or 20 mm in maximum basal diameter or tumors located within 3 mm of the optic nerve measuring at least 8 mm in maximum thickness or 16 mm in maximum basal diameter met inclusion criteria. Main outcome measures were frequency of (1) anterior segment complications (lash loss, keratopathy, cataract, and neovascular glaucoma), (2) posterior segment complications (vitreous hemorrhage, radiation retinopathy, and radiation papillopathy), (3) treatment failure (tumor growth, enucleation, or metastases), and (4) final visual acuity. RESULTS Median follow-up was 28 months. Mean age at treatment was 58.3 years. The frequencies of hypertension and diabetes mellitus were 14.3% and 9.5%, respectively. Mean tumor thickness and mean basal diameter were 8.6 mm and 18.7 mm, respectively. Lash loss occurred in 52.4%; dry eye, in 23.8%; cataract, in 28.6%; neovascular glaucoma, in 38.1% (100% in patients with diabetes mellitus); radiation retinopathy, in 9.5%; and radiation papillopathy, in 9.5%. No patient developed radiation-associated scleral necrosis or vitreous hemorrhage. The 2-year Kaplan-Meier estimate of local tumor growth after treatment was 33%, and the rate of distant metastasis was 10%. Visual acuity of 20/200 or better was preserved in 25% of patients, including 4 patients (19%) who experienced an average of 4 lines of Snellen visual acuity improvement. Development of neovascular glaucoma was associated with tumors in close proximity to the optic nerve (P = .04), while cataract (P = .03) and lash loss (P = .02) occurred with more anteriorly located tumors. Proton beam radiotherapy provided a 67% probability of local control and 90% probability of clinically discernible metastases-free survival at 24 months after treatment. CONCLUSION Proton beam radiotherapy is an ocular-conserving option that may be considered for the treatment of extra-large uveal melanoma in carefully selected patients.
Pathological Role of Regulatory T Cells in the Initiation and Maintenance of Eczema Herpeticum Lesions

It remains unknown why the occurrence of eczema herpeticum (EH) caused by an extensive disseminated cutaneous infection with HSV-1 or HSV-2 is associated with the exacerbation of atopic dermatitis lesions after withdrawal of treatment. Although regulatory T cells (Tregs) limit the magnitude of HSV-specific T cell responses in mice, their role in the induction and resolution of EH has not been defined. We initially investigated the frequencies, phenotype, and function of Tregs in the peripheral blood of atopic dermatitis with EH (ADEH) patients at onset and after clinical resolution, atopic dermatitis patients without EH, and healthy controls. Tregs with the skin-homing phenotype and the activated/induced phenotype were expanded at onset and contracted upon resolution. Treg-suppressive capacity was retained in ADEH patients and, the expanded Tregs suppressed IFN-γ production from HSV-1–specific CD8+ and CD4+ T cells. The increased frequency of CD14dimCD16+ proinflammatory monocytes (pMOs) was also observed in the blood and EH skin lesions. Thus, pMOs detected in ADEH patients at onset were characterized by an increased ability to produce IL-10 and a decreased ability to produce proinflammatory cytokines, unlike their normal counterparts. Our coculture study using Tregs and pMOs showed that the pMOs can promote the expansion of inducible Tregs. Tregs were detected frequently in the vicinity of HSV-expressing and varicella zoster virus–expressing CD16+ monocytes in the EH lesions. Expansions of functional Tregs, together with pMOs, initially required for ameliorating excessive inflammation occurring after withdrawal of topical corticosteroids could, in turn, contribute to the initiation and progression of HSV reactivation, resulting in the onset of EH.
Mammography stage of adoption among Iranian women

Background: Stage of Change and Health Belief Models are two the most common models that have been applied in mammography screening behaviors. The purpose of this study was to identify women in different stages of mammography adoption and to examine association between women's beliefs by stage of change among Iranian women. Methods: In this population-based study, mammography screening behavior determined using the Rakoweski stage of change scale, and women beliefs were determined by Farsi version of Champion's Health Belief Model scale (CHBMS). The obtained data were analyzed by SPSS (version 16.0) using statistical analysis of variance and Chi-square tests that used to determine relation between socio-demographic variables and HBM scales with stage of mammography. In all of the tests, a significant level α = 0.05 was considered. Results: According to stages of change distributions for mammography screening behavior, 36.2% were in pre-contemplation, 21.1% in contemplation, 4.2% in action, 6.2% in maintenance, and 32.3% were in relapse stage. There were significant differences in mammography stage by age, education, married status, family monthly income, husband job, information about breast cancer, and history of breast problems. ANOVA test showed significant differences by stages for all HBM scales, except to perceived severity. Conclusion: The findings indicated that women in pre-contemplation, relapse, and contemplation stages are more likely need to educational intervention, which emphasizes the benefits and barriers of mammography, health motivation, and self-efficacy. Furthermore, examining individuals’ beliefs about breast cancer and mammography screening by stage of mammography adoption is especially important in order to development of effectiveness interventions, which targeted to stage of change and promote mammography screening behavior.
When Do Markets Tip? A Cognitive Hierarchy Approach

The market structure of platform competition is critically important to managers and policy makers. Network effects in these markets predict concentrated industry structures, whereas competitive effects and differentiation suggest the opposite. Standard theory offers little guidance---full rationality models have multiple equilibria with wildly varying market concentration. We relax full rationality in favor of a boundedly rational cognitive hierarchy model. Even small departures from full rationality allow sharp predictions---there is a unique equilibrium in every case. When participants single-home and platforms are vertically differentiated, a single dominant platform emerges. Multihoming can give rise to a strong--weak market structure: one platform is accessed by all, and the other is used as a backup by some agents. Horizontal differentiation, in contrast, leads to fragmentation. Differentiation, rather than competitive effects, mainly determines market structure.
MASS STRANDING OF ODONTOCETI CAUSED BY PARASITOGENIC EIGHTH CRANIAL NEUROPATHY

Hearing organs of the Odontoceti from two mass strandings in 1983 and 1986 were examined histopathologically. In the 1983 stranding, two of three pilot whales (Globicephala macrorhynchus) were necropsied and numerous Nasitrema sp. were found close to the eighth cranial nerve (nervus vistibulo cochlearis) in both animals. Patchy degeneration of the eighth cranial nerve in and out of the modiolus of the cochlea was observed. In the 1986 stranding, five of 125 false killer whales (Pseudorca crassiclens) were examined and numerous trematodes (Nasitrema gondo) were found in the tympanic cavities. Severe degeneration of the eighth cranial nerve was discovered and there were many trematode eggs in the nervous and surrounding tissues. Parasitogenic eighth neuropathy is proposed again as the cause of mass stranding of the Odontoceti.