Miracle-dz/UniFAR-FTUs huggingface dataset:
CARACTERIZACIÓN ECOLÓGICA Y ESTABLECIMIENTO DE LOS CRITERIOS PARA DETERMINAR EL POTENCIAL ECOLÓGICO EN LAS SALINAS DE LA COMUNIDAD VALENCIANA

Las salinas son masas de agua situadas normalmente en el litoral, cuyo objeto es la obtencion de sal a traves de la evaporacion del agua de mar (o en algunos casos de aguas salinas continentales). Generalmente estan constituidas por un sistema de balsas someras cuya salinidad es mayor que la del agua marina y su ubicacion, modo de explotacion y la salinidad de las balsas, especialmente las que se dan al final del circuito, marcan la pauta para el desarrollo de las condiciones ambientales. Las elevadas concentraciones salinas hacen que estos sistemas presenten unas condiciones ambientales extremas a las que solo unos pocos organismos especializados han podido adaptarse. En la presente tesis doctoral se realiza un estudio exhaustivo de los principales parametros fisico-quimicos de estos ecosistemas tan extremos de la Comunidad Valenciana (salinas de Santa Pola, La Mata-Torrevieja y Calpe) que en gran medida estan determinados por las condiciones de gestion humana. El principal parametro considerado en el estudio de estos sistemas logicamente es la salinidad, que presenta diferencias significativas entre las salinas dadas las condiciones particulares de cada una de ellas. Ademas, se estudia el comportamiento de diversos parametros fisico-quimicos (pH, amonio, nitrito, nitrato, NID, PSR, relacion NID/PSR, PT y acido ortosilicico) asi como las variaciones que estos parametros presentan estacionalmente, a lo largo del gradiente salino, e incluso en diferentes zonas dentro de una misma salina. Se revisa si el estado de los diferentes parametros fisico-quimicos deriva del sistema de explotacion salinero o de causas distintas, y se realiza una comparacion entre salinas con el fin de determinar si existen pautas de comportamiento similares entre ellas, o por el contrario, particularidades propias de cada una. Finalmente, se procede a revisar los principales criterios a tener en cuenta para el establecimiento del potencial ecologico en las salinas de la Comunidad Valenciana.
A 60 $\mu$W High Linearity CMOS Peak-Stretcher/Discriminator

We present a pulse peak-stretcher/discriminator designed for applications where the constraints on power consumption and linearity are stringent. The circuit, realized in 0.35 mum CMOS technology, has almost two decades input signal range with a linearity error within - 0.08/ + 0.04%, measured at 33.6 mus peaking time. The circuit is supplied with a single voltage of 3.3 V with a total power consumption of 60 muW with a layout area of 125 mum x 65 mum.
Pharmacogénétique des analogues nucléosidiques : Cytidine déaminase et issue clinique

La prise en charge du cancer reste dependante de l’utilisation des agents cytotoxiques, avec les analogues nucleosidiques. Au-dela de leur similarite structurelle, certains de ces composes partagent une voie metabolique commune, ou la cytidine deaminase apparait comme enzyme majeure. L’existence d’une variabilite genetique et/ou phenotypique de la CDA nous a mene a nous interesser aux relations entre le statut CDA et l’issue clinique des patients afin de determiner si la CDA pouvait etre consideree comme biomarqueur d’issue clinique chez les patients.Nos travaux personnels ont consiste a evaluer deux techniques permettant de mesurer l’activite de la CDA. Nous avons publie le premier cas mondial de toxicites mortelles sous azacytidine chez un patient CDA-deficient, ainsi que le premier cas de deficience en CDA et de toxicites sous cytarabine causees par la presence d’une variation genetique du gene CDA chez une patiente transplantee hepatique. L’influence du statut CDA a egalement ete etudiee chez deux patients traites par azacytidine. Concernant la gemcitabine, nous avons demontre l’impact deletere en terme d’efficacite de l’augmentation de l’activite CDA chez les patients, ainsi que les resultats d’une etude multicentrique prospective dont le but etait de determiner si la CDA pouvait etre un marqueur predictif de l’apparition des toxicites sous gemcitabine, avec une etude pharmacocinetique en support. Les travaux preliminaires du pyrosequencage partiel de la CDA sur technologie Roche® sont presentes. L’ensemble de ces travaux de these confirme l’interet d’evaluer le statut CDA chez les patients susceptibles de recevoir une therapie a base d’analogues nucleosidiques.
Acute and chronic swine rete arteriovenous malformation models: hemodynamics and vascular remodeling.

BACKGROUND AND PURPOSE An acute and a chronic arteriovenous malformation (AVM) model were developed by using the swine rete to study hemodynamics and vascular remodeling. The models were also used to study in vivo polymerization kinetics and the distribution of various N-butyl 2-cyanoacrylate (NBCA) and Lipiodol mixtures. METHODS In the acute swine AVM model, retrograde flow through the left side of the rete was created by the placement of an endovascular shunt through the ipsilateral ascending pharyngeal artery. In the chronic model, flow was redirected retrograde through the left side of rete and ascending pharyngeal artery by creating an arteriovenous fistula between the ipsilateral jugular vein and the common carotid artery. After a period of at least 6 months, the entire head with the rete was connected to a perfusion loop driven by a peristaltic pump. A total of 30 swine were used for both the acute (n = 23) and chronic groups (n = 7). Hemodynamic parameters, including the flow and pressure drop across the rete, were recorded before NBCA embolization. Image processing was used on high-resolution radiographs of the explanted retia to measure the total rete length. Measurements of rete vessel calibers were based on histology. RESULTS The pressure gradients across retia were higher in the chronic model than in the acute model, but they did not reach the level of statistical significance (23.7 +/- 12.0 mm Hg vs 15.4 +/- 1.4 mm Hg). The rete blood outflow was significantly higher in the chronic model compared with the acute one (139.9 +/- 100.3 mL/min vs 32.5 +/- 17.6; P = .03). The rete length in the chronic model was significantly higher than in the acute model (593.1 +/- 39.9 vs 401.3 +/- 65.2 pixel; P < .001). The average vessel diameter of the rete in the chronic group was 520 microm and 320 microm in the control animals. CONCLUSION Increased pressure gradients and flow in the chronic swine rete AVM model may be related to increased size and decreased impedance. The resulting hemodynamic changes reflect a true flow-induced vascular remodeling rather than a simple change related to aging and size of the animal.
Authentication on the Go: Assessing the Effect of Movement on Mobile Device Keystroke Dynamics

Transparent authentication based on behavioral biometrics has the potential to improve the usability of mobile authentication due to the lack of a possibly intrusive user interface. Keystroke dynamics, or typing behavior, is a potentially rich source of biometric information for those that type frequently, and thus has been studied widely as an authenticator on touch-based mobile devices. However, the typingwhile-moving scenario that characterizes mobile device use may change keystroke-based patterns sufficiently that typing biometrics-based authentication may not be viable. This paper presents a user study on the effects of user movement while typing on the effectiveness of keystroke dynamics as an authenticator. Using the dynamic text-based keystroke timings of 36 study participants, we first show that näıvely measuring patterns without considering position (e.g., sitting, standing or walking while typing) results in generic patterns that are little better than chance. We show that first determining the user’s position before classifying their typing behavior, our two-phased approach, inferred the user’s position with an AUC of above 90%, and the user’s typing pattern was classified with an AUC of over 93%. Our results show that user typing patterns are a viable secondary or continuous post-PIN authentication method, even when movement changes a user’s typing pattern.
Anxiety in medically ill children/adolescents

Anxiety disorders are thought to be one of the most common psychiatric diagnoses in children/adolescents. Chronic medical illness is a significant risk factor for the development of an anxiety disorder, and the prevalence rate of anxiety disorders among youths with chronic medical illnesses is higher compared to their healthy counterparts. Anxiety disorders may develop secondary to predisposing biological mechanisms related to a child's specific medical illness, as a response to being ill or in the hospital, a threatening environment, as a result of other genetic and psychological factors, or as a combination of all these factors. Additionally, exposure to physical pain early in one's life and/or frequent painful medical procedures are correlated with fear and anxiety during subsequent procedures and treatments, and may lead to medical nonadherence and other comorbidities. Anxiety disorders can have serious consequences in children/adolescents with chronic and/or life‐limiting medical illnesses. Therefore, proper identification and treatment of anxiety disorders is necessary and may improve not only psychiatric symptoms but also physical symptoms. Behavioral and cognitive methods as well as psychotropic medications are used to treat anxiety disorders in pediatric patients. We will review current treatments for anxiety in children/adolescents with medical illnesses and propose future research directions. Depression and Anxiety, 2011. © 2010 Wiley‐Liss, Inc.
Subcutaneous and Sublingual Immunotherapy in Allergic Asthma in Children

This review presents up-to-date understanding of immunotherapy in the treatment of children with allergic asthma. The principal types of allergen immunotherapy (AIT) are subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). Both of them are indicated for patients with allergic rhinitis and/or asthma, who have evidence of clinically relevant allergen-specific IgE, and significant symptoms despite reasonable avoidance measures and/or maximal medical therapy. Studies have shown a significant decrease in asthma symptom scores and in the use of rescue medication, and a preventive effect on asthma onset. Although the safety profile of SLIT appears to be better than SCIT, the results of some studies and meta-analyses suggest that the efficacy of SCIT is better and that SCIT has an earlier onset than SLIT in children with allergic asthma. Severe, not controlled asthma, and medical error were the most frequent causes of SCIT-induced adverse events.
Respiratory infection complicating HIV infection

Purpose of reviewRespiratory infections remain a major cause of morbidity among HIV-infected persons. Thus, knowledge of recent advances regarding HIV-associated opportunistic pneumonias is crucial for optimal care of HIV-infected persons. Recent findingsBacterial pneumonia is the most common HIV-associated opportunistic pneumonia in the USA and its incidence remains appreciable. Worldwide, tuberculosis dominates the clinical picture. The absence of rapid, affordable diagnostics for active and latent tuberculosis remains a major obstacle that must be overcome if the global epidemic is to be slowed. The specter of extensively drug resistant tuberculosis and its overlap with HIV infection highlight the importance of rapid diagnostics and the need for accessible drug susceptibility testing. Pneumocystis (carinii) jirovecii pneumonia appears to be a more common pneumonia among HIV-infected persons residing in developing countries than was previously appreciated. Similar to tuberculosis, the absence of available diagnostics in developing areas is a major obstacle to clinical care and epidemiologic studies. The critical care of HIV-infected persons is challenging. SummaryAlthough tremendous advances have been made in our understanding of the management, treatment, and prevention of HIV and its associated respiratory infections, significant gaps remain. Thus, continued epidemiologic, clinical, and bench research is needed.
Investigation of different width size of transistor on internal resistance and output power in CMOS rectifier using two PMOS and NMOS

This paper presents the simulation studies on different width size of PMOS and NMOS on internal resistance and output power in CMOS rectifier. This investigation focuses on the internal resistance of the MOSFET and output power in the rectifier. The proposed CMOS rectifier considered the PMOS carrier mobility by increasing the width size of transistors rapidly. This simulation is done using CADENCE simulation software. The best configuration of CMOS rectifier is selected based on the total internal resistance and output power of the CMOS rectifier.
Intensification of therapeutic approaches reduces mortality in diabetic patients with acute myocardial infarction: the Munich registry.

OBJECTIVE The myocardial infarction (MI) registry of the Academic Schwabing Hospital, Munich, investigates the hospital course of diabetic and nondiabetic patients with acute MI. The aim of this study was to improve quality care management and to compare hospital mortality and therapeutic approaches (i.e., PTCA, stenting, GPIIb/IIIa receptor antagonists, glucose-insulin infusion). RESEARCH DESIGN AND METHODS Data of diabetic patients and nondiabetic patients were analyzed. All diabetic and nondiabetic subjects who were admitted in 1999 and 2001 were included: 1999, 126 (38%) diabetic and 204 (62%) nondiabetic patients; 2001, 91 (31%) diabetic and 205 (59%) nondiabetic patients. RESULTS In 1999, coronary angiography (P < 0.01), percutaneous transluminal coronary angioplasty (PTCA) (P < 0.001), and stenting (P < 0.001) were performed less frequently in diabetic than in nondiabetic patients. During this period, total hospital mortality (29 vs. 16%, P < 0.01) and mortality within 24 h after admission (14 vs. 5%, P = 0.01) were higher in diabetic than in nondiabetic patients. In 2001, frequencies of coronary angiography, PTCA, and stenting were increased in diabetic patients (P < 0.001 vs. 1999), and the interventions were comparable with those performed in nondiabetic patients. Furthermore, glucose-insulin infusion was administered in 46% of diabetic subjects. In 2001, total hospital mortality decreased to 17% in diabetic subjects (P = 0.028 vs. 1999) and mortality within 24 h after admission declined to 4% (P = 0.027 vs. 1999). Logistic regression analysis revealed that an increase in the number of therapeutic approaches (also when adjusted for clinical variables) is associated with a reduction in mortality of diabetic patients with acute MI (adjusted odds ratio 0.14, P < 0.0001). CONCLUSIONS Intensification of multiple advanced therapeutic strategies in diabetic patients with acute MI enables a substantial reduction in hospital mortality. The enforcement leads to rates of hospital mortality that are comparable to those of nondiabetic patients.
The Representation of the Metropolis in Scipio Slataper's Il mio Carso

Of the members of "the great generation of Triestine writers,"' Scipio Slataper is the most difficult to interpret fully.2 Part of this difficulty arises from the fact that Slataper's intellectual and cultural positions fluctuated in the years in which he was active as a writer and a critic. Furthermore, his premature death in 1915, at the age of 27, did not allow him to investigate thoroughly the possibilities inherent in the existential crisis that he witnessed in his time and thematized in his
The collaborative atorvastatin diabetes study: preliminary results *

The Collaborative AtoRvastatin Diabetes Study (CARDS) is the first large primary prevention study to focus specifically on the role of a statin in patients aged 40–75 years with type 2 diabetes, but no signs or symptoms of pre‐existing vascular disease and who had only average or below average cholesterol levels. The trial was a prospective double‐blind randomised trial with 2383 type 2 diabetic subjects randomised to either 10‐mg atorvastatin daily or placebo. Originally designed to run for 5 years, the trial was terminated over a year early in June 2003 on account of a clear benefit demonstrated for the intervention group. Over half of patients had a low‐density lipoprotein cholesterol (LDL‐C) below 3.3 mmol/l at entry and a quarter had an LDL‐C <2.6 mmol/l. Atorvastatin 10 mg reduced LDL‐C by 40% (1.2 mmol/l) on average. Results at 4 years showed a 37% relative risk reduction (p < 0.001) for atorvastatin 10 mg in the primary endpoint (acute coronary heart disease death, fatal or non‐fatal myocardial infarction, unstable angina requiring hospital admission, resuscitated cardiac arrest, coronary revascularisation procedures and stroke). Among the secondary endpoints, total mortality was reduced by 27% (p = 0.05), acute coronary events by 36%, coronary revascularisation by 31% and stroke by 48%. The same magnitude of benefit was observed among patients with LDL‐C above or below 3 mmol/l. Results observed were against a background where 9% of placebo patients had been permitted to start statin therapy after enrolment and 15% of patients on active treatment had discontinued atorvastatin. The true benefit of the intervention is therefore probably around 25% greater than the intention to treat analysis reports.
Direct evidence that natural killer cells in nonimmune spleen cell populations prevent tumor growth in vivo

Relatively large numbers of nonimmune spleen cells do not protect against the local growth of two lymphomas. However, this heterogeneous population of splenic lymphocytes contains a subset of cells that efficiently protects against in vivo tumor growth. This cell population (cell-surface phenotype Thyl.2(-)Ig(-)Ly5.1(+)) represents less than 5 percent of the spleen cell population and is responsible for in vitro NK-mediated lysis. Although these studies clearly and directly demonstrate that Ly5(+) NK cells selected from a heterogeneous lymphoid population from nonimmune mice can protect syngeneic mice against local in vivo growth of two different types of tumor cells (in contrast to other lymphocyte sets within the spleen), they do not directly bear upon the role of NK cells in immunosurveillance. They do indicate that highly enriched Ig(-)Thyl(-)Ly5(+) cells, which account for virtually all in vitro NK activity, can retard tumor growth in vivo. It is difficult to ascribe all anti-tumor surveillance activity to NK cells, because they probably do not recirculate freely throughout the various organ systems of the body. Perhaps NK ceils may play a role in prevention of neoplastic growth within discrete anatomic compartments where there is rapid differentiation of stem cells to mature progeny (e.g., bone marrow, spleen, and portions of the gastrointestinal tract)and may normally act to regulate the growth and differentiation of non-neoplastic stem cells. Long-term observation of chimeric mice repopulated with bone marrow from congenic or mutant donors expressing very low or very high NK activity may help to answer these questions.
Substance use through adolescence into early adulthood after childhood‐diagnosed ADHD: findings from the MTA longitudinal study

BACKGROUND Inconsistent findings exist regarding long-term substance use (SU) risk for children diagnosed with attention-deficit/hyperactivity disorder (ADHD). The observational follow-up of the Multimodal Treatment Study of Children with ADHD (MTA) provides an opportunity to assess long-term outcomes in a large, diverse sample. METHODS Five hundred forty-seven children, mean age 8.5, diagnosed with DSM-IV combined-type ADHD and 258 classmates without ADHD (local normative comparison group; LNCG) completed the Substance Use Questionnaire up to eight times from mean age 10 to mean age 25. RESULTS In adulthood, weekly marijuana use (32.8% ADHD vs. 21.3% LNCG) and daily cigarette smoking (35.9% vs. 17.5%) were more prevalent in the ADHD group than the LNCG. The cumulative record also revealed more early substance users in adolescence for ADHD (57.9%) than LNCG (41.9%), including younger first use of alcohol, cigarettes, marijuana, and illicit drugs. Alcohol and nonmarijuana illicit drug use escalated slightly faster in the ADHD group in early adolescence. Early SU predicted quicker SU escalation and more SU in adulthood for both groups. CONCLUSIONS Frequent SU for young adults with childhood ADHD is accompanied by greater initial exposure at a young age and slightly faster progression. Early SU prevention and screening is critical before escalation to intractable levels.
Efficacy and safety of stabilised hydrogen peroxide cream (Crystacide) in mild-to-moderate acne vulgaris: a randomised, controlled trial versus benzoyl peroxide gel.

BACKGROUND Benzoyl peroxide (BP) is a first-line topical treatment in acne vulgaris (AV). However, its use can cause mild skin irritation and dryness. A new formulation of hydrogen peroxide stabilised (HPS) in monoglycerides cream (Crystacide 1%), indicated in the topical treatment of superficial skin infections, is now available as an alternative treatment. STUDY AIM To evaluate efficacy and local tolerability of HPS in mild-to-moderate AV in comparison with BP gel. METHODS AND PATIENTS In a randomised, prospective, investigator-masked parallel-group, 8-week trial, 60 patients (24 men, 36 women, mean age 25 +/- 6 years) with mild-to-moderate AV, affecting mainly the face, were enrolled in the study, after their informed consent. HPS or BP (PanOxyl gel 4%) was applied topically twice daily for 8 weeks. STUDY OUTCOMES The study endpoints were: (1) Reduction in mean inflammatory (IL), noninflammatory (NIL) and total (TL) acneic lesions in comparison with baseline; (2) Local tolerability assessed evaluating erythema, dryness and burning sensation, using a 0-3 qualitative score (score 0 = poor tolerability; score 3 = very good tolerability). RESULTS TL, NIL, and IL were assessed by an investigator unaware of treatment allocation at baseline, and week 8. The tolerability score (TS) was assessed at week 4 and 8. At baseline, the two groups were well matched for the main clinical and demographic characteristics. All patients concluded the trial. At week 0, in the HPS group TL, NIL and IL (mean +/- SD) were: 35 +/- 8, 20 +/- 6 and 16 +/- 7. At week 8, HPS reduced TL to 16 +/- 7; NIL to 9 +/- 3 and IL to 7 +/- 3 (p < 0.001). At baseline, TL, NIL and IL, in the BP group, were 32 +/- 9, 24 +/- 8 and 18 +/- 7, respectively. At week 8, BP reduced TL, NIL and IL to 14 +/- 9; 7 +/- 5 and 7 +/- 3 (p < 0.001). In comparison with baseline values, the percentage reductions of IL were 58% and 61% for HPS and BP,respectively (p = n.s.). At the end of the study the TS was 2.9 +/- 0.2 in HPS group and 2.4 +/- 0.8 in BP group (p < 0.025). Two patients in HPS group (6%) and seven patients (23%) in BP group suffered from mild-to-moderate local erythema. CONCLUSIONS HPS has shown to be as effective as BP in reducing both inflammatory and noninflammatory AV lesions in patients with mild-to-moderate disease. In comparison with BP 4% gel, HPS cream shows a better local tolerability profile.