Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of Occult Bone Marrow Micrometastases in Patients with Operable Lung Carcinoma

Objectives A large proportion of patients with operable lung carcinoma (no evidence of systemic spread of tumor) develop metastatic disease after primary therapy. More sensitive and specific methods are needed to identify patients at highest risk for recurrence who may benefit most from adjuvant therapy, while sparing those patients who do not require such treatment. Summary Background Data Using epithelial‐specific monoclonal antibodies, the authors have developed an immunocytochemical assay capable of detecting as few as 2 lung cancer cells in 1 million bone marrow cells. Methods The assay was used to test the bone marrow (from resected ribs) of 43 patients with primary nonsmall cell lung carcinoma who showed no clinical or pathologic evidence of systemic disease. Results Occult bone marrow micrometastases (BMMs) were detected in 40% of patients (17/43) with non‐small cell lung cancer, including 29% (5/17) of patients with stage I or II disease and 46% of whom (12/26) had stage III disease. The median follow‐up was 13.6 months. Patients with occult BMMs had significantly shorter times to disease recurrence compared with patients without BMMs (7.3 vs. >35.1 months, p = 0.0009). Furthermore, for patients with stage I or II disease, the presence of occult BMMs was significantly associated with a higher rate of recurrence (p = 0.0004). Conclusions The detection of occult BMMs identifies patients with operable non‐small cell lung carcinoma who are at significantly increased risk for recurrence, independent of tumor stage, and may be useful in evaluating patients for adjuvant treatment protocols.
Financial Performance Adjustment in English Local Governments

type="main"> This paper analyses financial performance adjustment in English local governments and the specific accruals used to achieve it. Based on statistical approaches used in previous literature, our results indicate the use of abnormal accruals in English local governments in order to report surpluses/deficits close to zero as well as to avoid reporting big deficits. We find that depreciation and impairment expense of fixed assets is the item most significantly related to abnormal accruals. Consistent with the conservatism theory, local governments with higher leverage use more income-decreasing accounting policies.
Microsomal triglyceride transfer protein polymorphism (−493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C

Background: Hepatic steatosis may promote progression of chronic hepatitis C (CHC). Microsomal triglyceride transfer protein (MTP) is required for assembly and secretion of ApoB lipoprotein and is implicated in hepatitis C virus (HCV)‐related steatosis. The MTP −493G/T polymorphism may promote liver fat accumulation, but its role in HCV‐related steatosis is still unclear.
An open-ended approach to evaluating Android faces

Expectation and intention understanding through nonverbal behavior is a key topic of interest in socially embedded robots. This study presents the results of an open-ended evaluation method pertaining to the interpretation of Android facial expressions by adult subjects through an online survey with video stimuli. An open-ended question yields more spontaneous answers regarding the situation that can be associated with the synthetic emotional displays of an Android face. The robot used was the Geminoid-DK, while communicating the six basic emotions. The filtered results revealed situations highly relevant to the portrayed facial expressions for the emotions of Surprise, Fear, Anger, and Happiness, and less relevant for the emotions of Disgust, and Sadness. Statistical analysis indicated the existence of a moderate degree of correlation between the emotions of Fear-Surprise, and a high degree of correlation between the pair Disgust-Sadness. With a set of validated facial expressions prior to nonverbal emotional communication, androids and other humanoids can convey more accurate messages to their interaction partners, and overcome the limitations of their current limited affective interface.
Regulation of left-right asymmetries in the zebrafish by Shh and BMP4.

Left-right (LR) asymmetry of the heart in vertebrates is regulated by early asymmetric signals in the embryo, including the secreted signal Sonic hedgehog (Shh), but less is known about LR asymmetries of visceral organs. Here we show that Shh also specifies asymmetries in visceral precursors in the zebrafish and that cardiac and visceral sidedness are independent. The transcription factors fli-1 and Nkx-2.5 are expressed asymmetrically in the precardiac mesoderm and subsequently in the heart; an Eph receptor, rtk2, and an adhesion protein, DM-GRASP, mark early asymmetries in visceral endoderm. Misexpression of shh mRNA, or a dominant negative form of protein kinase A, on the right side reverses the expression of these asymmetries in precursors of both the heart and the viscera. Reversals in the heart and gut are uncoordinated, suggesting that each organ interprets the signal independently. Misexpression of Bone Morphogenetic Protein (BMP4) on the right side reverses the heart, but visceral organs are unaffected, consistent with a function for BMPs locally in the heart field. Zebrafish mutants with midline defects show independent reversals of cardiac and visceral laterality. Thus, hh signals influence the development of multiple organ asymmetries in zebrafish and different organs appear to respond to a central cascade of midline signaling independently, which in the heart involves BMP4.
Terrestrial Soft-Bodied Protists and Other Microorganisms in Triassic Amber

Protozoa, cyanobacteria, sheathed algae, sheathed fungi, germinating pollen or spores, and fungal spores have been found in amber 220 to 230 million years old. Many of these microorganisms can be assigned to present-day groups. This discovery of terrestrial, soft-bodied protists that can be referred to modern groups indicates that morphological evolution is very gradual in many protists and that both structural and probably functional stasis extend back at least to the Upper Triassic period.
JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype.

JC virus has a transforming gene encoding JC virus T-antigen (JCVT). JCVT may inactivate wild-type p53, cause chromosomal instability (CIN), and stabilize beta-catenin. A link between JCVT and CpG island methylator phenotype (CIMP) has been suggested. However, no large-scale study has examined the relations of JCVT with molecular alterations, clinical outcome, or prognosis in colon cancer. We detected JCVT expression (by immunohistochemistry) in 271 (35%) of 766 colorectal cancers. We quantified DNA methylation in eight CIMP-specific promoters (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1) and eight other loci (CHFR, HIC1, IGFBP3, MGMT, MINT1, MINT31, p14, WRN) by MethyLight. We examined loss of heterozygosity in 2p, 5q, 17q, and 18q. JCVT was significantly associated with p53 expression (P < .0001), p21 loss (P < .0001), CIN (>/=2 chromosomal segments with LOH; P < .0001), nuclear beta-catenin (P = .006), LINE-1 hypomethylation (P = .002), and inversely with CIMP-high (P = .0005) and microsatellite instability (MSI) (P < .0001), but not with PIK3CA mutation. In multivariate logistic regression analysis, the associations of JCVT with p53 [adjusted odds ratio (OR), 8.45; P < . 0001], CIN (adjusted OR, 2.53; P = .003), cyclin D1 (adjusted OR, 1.57; P = .02), LINE-1 hypomethylation (adjusted OR, 1.97 for a 30% decline as a unit; P = .03), BRAF mutation (adjusted OR, 2.20; P = .04), and family history of colorectal cancer (adjusted OR, 0.64; P = .04) remained statistically significant. However, JCVT was no longer significantly associated with CIMP, MSI, beta-catenin, or cyclooxygenase-2 expression in multivariate analysis. JCVT was unrelated with patient survival. In conclusion, JCVT expression in colorectal cancer is independently associated with p53 expression and CIN, which may lead to uncontrolled cell proliferation.
Étude comparative de la dyspraxie : évaluation neuropsychologique d ’ enfants porteurs d ’ une dyspraxie développementale ou consécutive à la prématurité Comparative study of dyspraxia : Neuropsychological evaluation of children with developmental dyspraxia or consecutive to a preterm birth

Objectives. – The aim of the present study was to compare and contrast developmental dyspraxia and dyspraxia following preterm birth. Material. – Three different domains (attention–executive function, sensorimotor and visuospatial functions) were evaluated using Nepsy battery tests and the Purdue pegboard test. Method. – The results of a neuropsychological evaluation of 32 children with developmental dyspraxia (the DVLT group) were compared with those of 16 children with dyspraxia following preterm birth (the AP group). The population inclusion and exclusion criteria were set according to Gérard’s (Gérard C-L. Le concept de dyspraxie. In: Gérard C-L, Brun V, editors. Les dyspraxies de l’enfant. Paris: Masson; 2005. p. 15–24.) definition of dyspraxia. * Auteur correspondant. Adresse e-mail : valergo.garches@rpc.aphp. fr (V. Barray). 0168-6054/$ – see front matter # 2008 Elsevier Masson SAS. Tous droits réservés. doi:10.1016/j.annrmp. 2008.01. 004 V. Barray et al. / Annales de réadaptation et de médecine physique 51 (2008) 161–168 162 Results. – The two groups had similar visuospatial performance. However, differences between the DVLT and AP children appeared in a test of attention–executive function (visual attention, specifically) and in some sensorimotor tests, with better performance by the DVLT group in all situations. Conclusion. – The difficulties exhibited by preterm-born children (poor upper limb motor control, more severe dyspraxia and the presence of oculomotor impairments) could explain the latter’s poor performance relative to children with developmental dyspraxia. Indeed, oculomotor impairments are especially likely to impair performance in visual attention and visuomotor accurary tests — the two situations in which pretermborn children performed worse. # 2008 Elsevier Masson SAS. Tous droits réservés. Mots clés : Dyspraxie développementale ; Prématurité ; Visuospatial ; Attention–exécutif ; Sensorimoteur
Explanatory model of help-seeking and coping mechanisms among depressed women in three ethnic groups of Fars, Kurdish, and Turkish in Iran.

BACKGROUND As one of the most prevalent diseases globally and as an important cause of disability, depressive disorders are responsible for as many as one in every five visits to primary care doctors. Cultural variations in clinical presentation, sometimes make it difficult to recognize the disorder resulting in patients not being diagnosed and not receiving appropriate treatment. To address this issue, we conducted a qualitative pilot study on three ethnic groups including Fars, Kurdish, and Turkish in Iran to test the use of qualitative methods in exploring the explanatory models of help-seeking and coping with depression (without psychotic feature) among Iranian women. METHODS A qualitative study design was used based on an explanatory model of illness framework. Individual interviews were conducted with key informant (n=6), and depressed female patients (n=6). A hypothetical case vignette was also used in focus group discussions and individual interviews with lay people (three focus groups including 25 participants and six individual interviews; n=31). RESULTS There were a few differences regarding help-seeking and coping mechanisms among the three ethnic groups studied. The most striking differences were in the area of treatment. Non-psychotic depressive disorder in all ethnicities was related to an external stressor, and symptoms of illness were viewed as a response to an event in the social world. Coping mechanisms involved two strategies: (1) solving problems by seeking social support from family and neighbors, religious practice, and engaging in pleasurable activities, and (2) seeking medical support from psychologists and family counselors. The Fars group was far more likely to recommend professional treatment and visiting psychiatrists whereas the other two ethnic groups (i.e., Turks and Kurds) preferred to consult family counselors, psychologists or other alternative care providers, and traditional healers. CONCLUSION The study has educational and clinical implications. Cultural reframing of the patient's and family's perceptions about mental illness and depression may require community education. Family counseling, family therapy, and also religious practices can be used to empower the patient.
Stress levels of dental students at the Fiji School of Medicine.

INTRODUCTION The Fiji School of Medicine is the primary health care educational institution in Fiji and possesses the only dental school in the Pacific. The oral health programme is a multi-entry/exit programme. The aim of this study was to determine the perceived sources or stress and at risk groups within the undergraduate oral health care programmes. METHODS A modified version of the Dental Environment Stress questionnaire was used to assess levels of stress for 41 items. RESULTS A total of 115 undergraduate students participated (response rate = 84%). Of the respondents, 54% were male and 46% were female; 55% were Indo-Fijians, 18% Indigenous-Fijians, 8% Polynesians, 7% Micronesians, whilst Melanesians and others were each 6%. Moderate to severe stressful items were: full loaded day, followed by criticism from clinical supervisors in front of patients, amount of assigned work, fear of failing a course or year, examination and grades, financial resources, fear of employment after graduation and fear of facing parents after failure. Of the questionnaire items, 24% had significant differences across year groups. Overall, third years were most stressed followed by fourth years, fifth years, first years and second years. Indo-Fijians were the most stressed, followed by Indigenous-Fijians, Polynesians, others and Melanesians. Females were significantly more stressed than males for 27% of items. Private fee-paying students were more stressed than sponsored students. CONCLUSION Overall stress levels were slight to moderate and were higher in senior years, Indo-Fijians, females and private fee-paying students.
Enhancement of obliterative airway disease in rat tracheal allografts infected with recombinant rat cytomegalovirus.

BACKGROUND Cytomegalovirus infection has been identified as a significant risk factor for the development of obliterative bronchiolitis in human lung transplant recipients. This study was designed to assess the influence of rat cytomegalovirus (RCMV) on the pathogenesis and development of obliterative bronchiolitis in an experimental model of obliterative airway disease, which occurs after allogenic heterotopic tracheal transplantation in rodents. METHODS Sixty Lewis rats were infected intraperitoneally with 10(7) plaque-forming units of recombinant lac-Z-tagged RCMV expressing the gene for beta-galactosidase. Rats were either infected at the time of surgery (acute infection, n = 30) or 56 days before surgery (chronic infection, n = 30). Tracheae from Brown Norway (allograft) or Lewis (isograft) rats were implanted and wrapped in the greater omentum of infected Lewis rats. RCMV infection was verified in different recipient tissues by in vitro plaque-assays and by direct in situ staining for beta-galactosidase activity. The tracheal grafts were harvested on days 7, 14, and 21 after transplantation and stained with hematoxylin-eosin and Masson's trichrome. The peritracheal cellular inflammation was scored visually. The cellular density of the infiltrating cells and the extent of airway obliteration were analyzed by use of computer-digitized morphometry and compared with uninfected allografts as control. RESULTS Both acute and chronic cytomegalovirus infection produced significantly higher mononuclear cell density values on days 7 and 14 compared with noninfected controls, indicating a more intense immune response in the infected allografts. Tracheal allograft obliteration was also more extensive after acute and, in particular, after chronic cytomegalovirus infection (64% narrowing after 21 days compared with 36% in grafts from noninfected control animals). CONCLUSIONS Our experimental results provide direct evidence that the tracheal grafts were infected with RCMV and that the development of obliterative airway disease was enhanced in the acutely and chronically infected allografts compared with grafts from noninfected control animals.
Evaluation of the Transverse Craniofacial Morphology of Adolescents With Repaired Unilateral Cleft Lip and Palate Using Cone-Beam Computed Tomography

Aim:The aim of the study was to evaluate the transverse craniofacial morphology of the adolescent patients affected by unilateral cleft lip and palate (UCLP) and to compare the findings with age- and sex-matched control group without any cleft using their cone-beam computed tomography (CBCT) images. Methods:The study sample (n = 56 patients; mean age: 14.35 ± 3.06 years) consisted of 26 UCLP (n = 26 patients; 10 women and 16 men; mean age: 13.70 ± 2.94 years) and 30 control (n = 30 patients; 19 women and 11 men; mean age: 14.90 ± 3.10 years) subjects. Twenty-five conventional skeletal and dental tissue landmarks were identified. Twenty widely used frontal cephalometric variables (14 linear distances, 3 angles, and 3 ratios) were measured. The data were analyzed using the independent t-test between the groups. Results:Patients affected by UCLP had statistically significantly smaller interorbital width (89.83 ± 4.16 mm), maxillary width (58.02 ± 5.77 mm), maxillary intermolar width (52.83 ± 4.83 mm), and upper face height (57.64 ± 4.57 mm) (P < 0.05) compared with the control group. Conversely, ANS-isf distance was significantly greater in the UCLP group (29.62 ± 5.19 mm) than in the control group (26.74 ± 3.99 mm) (P = 0.023). Moreover, alveolar cleft width had significant effect on Cr-ANS (r = 0.446, P = 0.022) and the ANS-isf (r = 0.459, P = 0.018) measurements. Conclusion:The UCLP group showed statistically significantly smaller values for interorbital width, maxillary width, maxillary intermolar width, and upper face height than the noncleft controls.
Generation of Shox2‐Cre allele for tissue specific manipulation of genes in the developing heart, palate, and limb

Shox2 is expressed in several developing organs in a tissue specific manner in both mice and humans, including the heart, palate, limb, and nervous system. To better understand the spatial and temporal expression patterns of Shox2 and to systematically dissect the genetic cascade regulated by Shox2, we created Shox2‐LacZ and Shox2‐Cre knock‐in mouse lines. We show that the Shox2‐LacZ allele expresses beta‐galactosidase reporter gene in a fashion that recapitulates the endogenous Shox2 expression pattern in developing organs, including the sinoatrial node (SAN), the anterior portion of the palate, and the proximal region of the limb bud. Conditional deletion of Shox2 in mice carrying the Shox2‐Cre allele yielded SAN phenotypes that resemble conventional Shox2 knockout mice. Our results indicate that the Shox2‐Cre allele offer a useful tool for tissue specific manipulation of genes in a number of developing organs, particularly in the developing SAN. genesis 51:515–522. © 2013 Wiley Periodicals, Inc.
Rats with hippocampal damage are impaired on place learning in the water task when overtrained under constrained conditions

To date, numerous investigations have been conducted on the mammalian hippocampus to determine its precise function. This research has implicated a fundamental role for the hippocampus in the formation of a spatial map that an animal can use to appropriately guide behavior in complex relational tasks. Despite substantial evidence to support this view, there have been challenges to this theory of hippocampal function. One alternative view suggests that the hippocampus is involved with the integration and updating of voluntary movement. Therefore, any impairments expressed by rats with hippocampal damage are not due to the inability to form or use a spatial map, but rather arise because they are unable to accurately control and monitor on‐line movement. Accordingly, investigators, supporting the latter, claim that animals with hippocampal lesions are able to solve a spatial version of the water task if they are given explicit training on how to get to the hidden platform. In the present study we trained rodents with or without hippocampal damage on a cue/place water task for 40 days. In using behaviorally constraining procedures and by overtraining these animals, we provided them with knowledge of how to get to the hidden platform, and ensured enough time to learn the task. Our findings revealed that although rats with hippocampal lesions showed some place responses, they were significantly impaired on all measures of place learning compared to sham animals under these intensive procedures. Overall, the results of the present study do not support the idea that the hippocampus is not specifically involved in acquisition of place information in the water task. Hippocampus 2:153–161, 2000 © 2000 Wiley‐Liss, Inc.
600-V Normally Off ${\rm SiN}_{x}$ /AlGaN/GaN MIS-HEMT With Large Gate Swing and Low Current Collapse

In this letter, 600-V normally-OFF SiNx/AlGaN/GaN metal-insulator-semiconductor high-electron-mobility transistor (MIS-HEMT) is reported. Normally-OFF operation and low OFF-state gate leakage are obtained by using fluorine plasma ion implantation in conjunction with the adoption of a 17-nm SiNx thin film grown by plasma-enhanced chemical vapor deposition as the gate insulator. The normally-OFF MIS-HEMT exhibits a threshold voltage of +3.6 V, a drive current of 430 mA/mm at a gate bias of 14 V, a specific ON-resistance of 2.1 mΩ·cm2 and an OFF-state breakdown voltage of 604 V at a drain leakage current of 1 μA/mm with VGS=0 V, and the substrate grounded. Effective current collapse suppression is obtained by AlN/SiNx passivation as proved by high-speed pulsed I-V and low-speed high-voltage switching measurement results.