Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of usnic acid-induced apoptosis and autophagy in hepatocellular carcinoma

Usnic acid (UA) is a multifunctional bioactive lichen secondary metabolite with potential anti-cancer properties. Although the promising therapeutic effects of UA have been investigated in different cancer cell lines, the mechanism driving UA-induced cell death has yet to be elucidated. As the type of cell death (apoptosis or autophagy) induced by UA may vary depending on the cancer cell type, we first studied the cytotoxic effects of UA in HEPG2 (HBV(−)) and SNU-449(HBV(+)) hepatocellular carcinoma (HCC) cell lines. HCC cell viability was considerably reduced in a dose-dependent manner at 12, 24, and 48 h after treatment with UA (p < 0.05). However, SNU-449 cells were more sensitive to UA than HEPG2 cells. UA also induced apoptotic cell death in HCC cells with cell cycle arrest at G0/G1 and G2/M phase depending on the genetic profile of each cell type. On the other hand, we observed acidic vesicular organelles in HCC cells after 36 h of UA treatment. Taken together, these findings suggest that UA stimulates apoptosis and autophagy in HEPG2 and SNU-449 cells without damaging normal control cells. Thus, UA might be a potential therapeutic compound for HCC treatment. However, there is a need for further studies investigating the death-promoting or preventing roles for autophagy and the molecular signaling mechanisms induced by UA treatment.
‘Has she seen me?’: a multiple methods study of the pharmaceutical care needs of older people with sensory impairment in Scotland

Objectives To explore the pharmaceutical care needs of, and service provision to, older people with sensory impairment (visual, hearing and dual impairment) on prescribed polypharmacy (≥4 medicines) in Scotland. Design Interviews were conducted with older people with sensory impairment and community pharmacy personnel, which informed the content of a subsequent national cross-sectional survey of community pharmacists. Setting Scotland, 2015–2016. Participants Older people with sensory impairment and community pharmacy personnel. Results Interviews were completed with 23 older people with sensory impairment (dual impairment n=13, visual or hearing impairment n=5 of each) and 30 community pharmacy personnel from eight of 14 Scottish Health Boards. A total of 171 survey responses were received. Older people reported that they did not always disclose their sensory impairment to pharmacy personnel. They also reported that medicines were difficult to identify particularly when their name, shape or colour changed. Pharmacy personnel relied on visible cues such as white canes or guide dogs to identify visual impairment and suggested that hearing loss was less visible and more difficult to identify. Many assistive aids in support of medicine management, such as dosette boxes, seemed inadequate for complex medication regimens. Few community pharmacy personnel reported receiving training in the care of people with sensory impairment. Conclusions This is the first comprehensive, multistakeholder, in-depth exploration of the pharmaceutical care needs of older people with sensory impairment. Strategies are needed to enable people with sensory impairment to disclose their impairment to pharmacy personnel (and other healthcare providers). Community pharmacy personnel require training to deliver person-centred pharmaceutical care for older people with sensory impairment particularly regarding communication with individuals in this vulnerable population.
Effect of Temperature on the Physical, Electro-Chemical and Adsorption Properties of Carbon Micro-Spheres Using Hydrothermal Carbonization Process

This research deals with the effect of the temperature on the physical, thermal, electrochemical, and adsorption properties of the carbon micro-spheres using hydrothermal carbonization (HTC). Until recently, limited research has been conducted regarding the effects of delignification during the HTC process of biomass residues especially Dimocarpus longan. In this regard, lignin was first extracted from the lingo-cellulosic waste of Longan fruit peel (Dimocarpus longan). The holocellulose (HC) separated from lignin and raw biomass substrates (Longan fruit exocarp/peel powder, LFP) were carbonized at different temperatures using water as the green catalyst. Hydrothermal carbonization (HTC) was performed for both of the samples (LFP and HC) at 200 °C, 250 °C, and 300 °C for 24 h each. The surface morphological structures, the porosity, and the Brunauer-Emmett-Teller (BET) surface area of the prepared micro-spherical carbon were determined. The BET surface areas obtained for HC-based carbon samples were lower than that of the raw LFP based carbon samples. The carbon obtained was characterized using ultimate and proximate analyses. The surface morphological features and phase transformation of the synthesized micro-spherical carbon was characterized by a field-emission scanning electron microscopy (FE-SEM) and X-ray diffraction (XRD) analysis. The results demonstrated that the extraction of lignin could significantly alter the end properties of the synthesized carbon sample. The carbon spheres derived from LFP showed a higher carbon content than the HC-based carbon. The absence of lignin in the holo-cellulose (HC) made it easy to disintegrate in comparison to the raw, LFP-based carbon samples during the HTC process. The carbonaceous samples (LFP-300 and HC-300) prepared at 300 °C were selected and their adsorption performance for Pb (II) cations was observed using Langmuir, Freundlich, and Temkin linear isotherm models. At 30 °C, the equilibrium data followed the Langmuir isotherm model more than the Freundlich and Temkin model for both the LFP-300 sample and the HC-300 sample. The potential of the synthesized carbon microspheres were further analyzed by thermodynamic characterizations of the adsorption equilibrium system.
Visual Dominance Effect upon Passing the Central Bottleneck of Information Processing

Background: In the classical psychological refractory period (PRP) paradigm, two stimuli are presented in brief succession, and participants are asked to make separate speeded responses to both stimuli. Due to a central cognitive bottleneck, responses to the second stimulus are delayed, especially at short stimulus-onset asynchrony (SOA) between the two stimuli. Although the mechanisms of dual-task interference in the classical PRP paradigm have been extensively investigated, specific mechanisms underlying the cross-modal PRP paradigm are not well understood. In particular, it remains unknown whether the dominance of vision over audition manifests in the cross-modal PRP tasks. The present study aimed to investigate whether the visual dominance effect manifests in the cross-modal PRP paradigm. Methods: We adapted the classical PRP paradigm by manipulating the order of a visual and an auditory task: the visual task could either precede the auditory task or vice versa, at either short or long SOAs. Twenty-five healthy participants took part in Experiment 1, and thirty-three new participants took part in Experiment 2. Reaction time and accuracy data were calculated and further analyzed by repeated-measures analysis of variance. Results: The results showed that visual precedence in the Visual-Auditory condition caused larger impairments to the subsequent auditory processing than vice versa in the Auditory-Visual condition: a larger delay of second response was revealed in the Visual-Auditory condition (135 ± 10 ms) than the Auditory-Visual condition (88 ± 9 ms). This effect was found only at the short SOAs under the existence of the central bottleneck, but not at the long SOAs. Moreover, this effect occurred both when the single visual and the single auditory task were of equal difficulty in Experiment 1 and when the single auditory task was more difficult than the single visual task in Experiment 2. Conclusion: Results of the two experiments suggested that the visual dominance effect occurred under the central bottleneck of cognitive processing.
CT-wasm: type-driven secure cryptography for the web ecosystem

A significant amount of both client and server-side cryptography is implemented in JavaScript. Despite widespread concerns about its security, no other language has been able to match the convenience that comes from its ubiquitous support on the "web ecosystem" - the wide variety of technologies that collectively underpins the modern World Wide Web. With the introduction of the new WebAssembly bytecode language (Wasm) into the web ecosystem, we have a unique opportunity to advance a principled alternative to existing JavaScript cryptography use cases which does not compromise this convenience. We present Constant-Time WebAssembly (CT-Wasm), a type-driven, strict extension to WebAssembly which facilitates the verifiably secure implementation of cryptographic algorithms. CT-Wasm's type system ensures that code written in CT-Wasm is both information flow secure and resistant to timing side channel attacks; like base Wasm, these guarantees are verifiable in linear time. Building on an existing Wasm mechanization, we mechanize the full CT-Wasm specification, prove soundness of the extended type system, implement a verified type checker, and give several proofs of the language's security properties. We provide two implementations of CT-Wasm: an OCaml reference interpreter and a native implementation for Node.js and Chromium that extends Google's V8 engine. We also implement a CT-Wasm to Wasm rewrite tool that allows developers to reap the benefits of CT-Wasm's type system today, while developing cryptographic algorithms for base Wasm environments. We evaluate the language, our implementations, and supporting tools by porting several cryptographic primitives - Salsa20, SHA-256, and TEA - and the full TweetNaCl library. We find that CT-Wasm is fast, expressive, and generates code that we experimentally measure to be constant-time.
Impact of Deductible Health Plans on Parental Decision Making for Common Pediatric Otolaryngology Procedures

Objective To describe how deductible health plans affect parental decision making for common pediatric otolaryngology operations. Study Design A cross-sectional survey study. Setting Tertiary care pediatric hospital. Subjects and Methods Caregivers of patients aged <18 years were surveyed to assess factors in decision making related to common otolaryngologic surgical procedures, including outpatient tympanostomy tubes and adenotonsillectomy, between July 2015 and June 2016. Children in foster care and those who underwent nonelective surgery were excluded. Decision-making factors were statistically analyzed with univariate and multivariate ordinal logistic regression. Results A total of 155 caregivers completed the survey. The median age of the patient at the time of the surgery was 3 years. Surgical procedures included tympanostomy tube placement (51%), adenotonsillectomy (37%), tympanostomy tube placement with adenotonsillectomy (10%), and other (2%). The mean ± SD annual deductible per child was $1870 ± $140, and the mean maximum out-of-pocket expense was $3833 ± $235. The odds of having the deductible or out-of-pocket expense affect surgical decision making was greater for those covered under a high-deductible health plan (odds ratio = 2.27; 95% CI, 1.25-4.12; P = .007). Conclusion High-deductible health plans and out-of-pocket expenses can influence parental decision making for common otolaryngology operations, such as tympanostomy tube placement and adenotonsillectomy. Future studies are needed to determine if such policies affect access to care in the pediatric population.
Neighborhoods and Perceived Norms: Understanding the Impact of Neighborhoods on Perceived Norms and Cancer Screening

ABSTRACT This study examines the importance of urban ethnic neighborhoods as the context of everyday life, where normative influences on health are formed, modified, and maintained. Built on communication infrastructure theory, this study investigates the role of women’s connections to their neighborhood storytelling network—consisting of residents, local/ethnic media, and community organizations—in shaping their descriptive normative perceptions regarding cervical cancer screening. Specifically, we explore the communication mechanisms that underlie Latinas’ exposure and attention to media information about Pap tests, their discussions with health-care professionals about Pap tests, their perceptions about how normative Pap tests are among “women like them”, and their compliance with cervical cancer screening guidelines. Our findings suggest that neighborhood storytelling resources hold promise for health communication research to understand not only the uptake of Pap tests but also health disparities in other domains that affect diverse populations and communities.
Infinite Resources for Optimistic Concurrency Control

Optimistic concurrency control (OCC) is inefficient for high-contention workloads. When concurrent transactions conflict, an OCC system wastes CPU resources verifying transactions, only to abort them. This paper presents a new system, called Network Optimistic Concurrency Control (NOCC), which reduces load on storage servers by identifying transactions that will abort as early as possible, and aborting them before they reach the store. NOCC leverages recent advances in network data plane programmability to speculatively execute transaction verification logic directly in network devices. NOCC examines network traffic to observe and log transaction requests. If NOCC suspects that a transaction is likely to be aborted at the store, it aborts the transaction early by re-writing the packet header, and routing the packets back to the client. For high-contention workloads, NOCC improves transaction throughput, and reduces server load.
Volatile element evolution of chondrules through time

Significance We present time-anchored elemental abundance data for some of the Solar System’s first solids by tracking Pb−Pb dated chondrule compositions. Volatile element contents generally rise, while redox conditions (based on chondrule Mn/Na ratios) decline beginning ∼1 My after Solar System formation (∼4,567 Ma). These results reflect a continued rise in volatile element contents and their fugacities during chondrule recycling, and early water influx to the inner Solar System followed by its express removal. These observations support the early formation of Mars under oxidizing condition and Earth’s protracted growth under more reducing conditions in an environment increasing in volatile contents with time, while also calling into question the coupling of water and volatile elements during Solar System evolution. Chondrites and their main components, chondrules, are our guides into the evolution of the Solar System. Investigating the history of chondrules, including their volatile element history and the prevailing conditions of their formation, has implications not only for the understanding of chondrule formation and evolution but for that of larger bodies such as the terrestrial planets. Here we have determined the bulk chemical composition—rare earth, refractory, main group, and volatile element contents—of a suite of chondrules previously dated using the Pb−Pb system. The volatile element contents of chondrules increase with time from ∼1 My after Solar System formation, likely the result of mixing with a volatile-enriched component during chondrule recycling. Variations in the Mn/Na ratios signify changes in redox conditions over time, suggestive of decoupled oxygen and volatile element fugacities, and indicating a decrease in oxygen fugacity and a relative increase in the fugacities of in-fluxing volatiles with time. Within the context of terrestrial planet formation via pebble accretion, these observations corroborate the early formation of Mars under relatively oxidizing conditions and the protracted growth of Earth under more reducing conditions, and further suggest that water and volatile elements in the inner Solar System may not have arrived pairwise.
Adaptive Multiple Non-negative Matrix Factorization for Temporal Link Prediction in Dynamic Networks

The prediction of mobility, topology and traffic is an effective technique to improve the performance of various network systems, which can be generally represented as the temporal link prediction problem. In this paper, we propose a novel adaptive multiple non-negative matrix factorization (AM-NMF) method from the view of network embedding to cope with such problem. Under the framework of non-negative matrix factorization (NMF), the proposed method embeds the dynamic network into a low-dimensional hidden space, where the characteristics of different network snapshots are comprehensively preserved. Especially, our new method can effectively incorporate the hidden information of different time slices, because we introduce a novel adaptive parameter to automatically adjust the relative contribution of different terms in the uniform model. Accordingly, the prediction result of future network topology can be generated by conducting the inverse process of NMF form the shared hidden space. Moreover, we also derive the corresponding solving strategy whose convergence can be ensured. As an illustration, the new model will be applied to various network datasets such as human mobility networks, vehicle mobility networks, wireless mesh networks and data center networks. Experimental results show that our method outperforms some other state-of-the-art methods for the temporal link prediction of both unweighted and weighted networks.
POSS Nanofiller-Induced Enhancement of the Thermomechanical Properties in a Fluoroelastomer Terpolymer

The present study reports on the use of three types of polyhedral oligomeric silsesquioxanes (POSS) nanoparticles with various organic substituents as fillers in a fluoroelastomer (FKM). A series of/POSS elastomer composite thin films is prepared. Microstructural SEM/TEM (scanning electron microscopy/transmission electron microscopy) imaging reveals a dispersion state allowing the presence of micron-sized domains. The influence of POSS content is studied in order to optimize thermal stability and mechanical properties of the composite thin films. Both POSS-A (with an acryloyl functional group and seven isobutyl substituents) and POSS-P (with eight phenyl substituents) lead to higher thermal stability and modulus of the composites, with respect to the unfilled FKM terpolymer matrix. covalent grafting of POSS-A onto the FKM network is found to play a critical role. Enhanced storage modulus in the rubbery plateau region (+210% at 200 °C for 20 phr) suggests that POSS-A is particularly suitable for high temperature applications.
Changing negative autobiographical memories in the lab: a comparison of three eye-movement tasks

ABSTRACT There is strong evidence that executing eye-movement (EM) tasks that load working memory (WM) while thinking of an emotional memory reduces the emotionality and vividness of this memory. According to WM theory, EM tasks that load WM more should be more effective to devalue emotional memories. In this study, we compared three EM tasks: dot tracking, letter identification, and a combination of dot tracking and letter identification. First, participants completed a reaction time (RT) task to assess the WM load of the three EM tasks relative to a control task (viewing a black screen). Then, participants were asked to think of a negative autobiographical memory while executing one of these EM tasks and asked to recall another negative memory while executing the control task. Before and after each task, participants rated emotionality and vividness of the memory. All EM tasks slowed down RTs relative to the control task, and the letter identification task induced the largest RTs. Reductions of vividness relative to the control task, however, were comparable across the EM tasks, and there were no reliable reductions of emotionality. We discuss these findings in light of the WM theory and alternative theories for the effects of dual-task interventions.
Training Needs of Manitoba Pharmacists to Increase Application of Assessment and Prescribing for Minor Ailments into Practice: A Qualitative and Quantitative Survey

Current literature demonstrates the positive impact of pharmacists prescribing medication on patient outcomes and pharmacist perceptions of the practice. The aim of this study was to understand the factors affecting prescribing practices among Manitoba pharmacists and identify whether additional training methods would be beneficial for a practice behavior change. A web-based survey was developed and participation was solicited from pharmacists in Manitoba. Descriptive statistics were calculated to summarize the frequency of demographic characteristics. Chi-square tests were used to explore possible correlations between variables of interest and thematic analysis of qualitative data was completed. A total of 162 participants completed the survey. The response rate was 12.3%. Of those who had met the requirements to prescribe, none were doing so on a daily basis and 23.5% had not assessed or prescribed since being certified. Respondents identified the top barriers for providing this service as a lack of sufficient revenue and a lack of time. Qualitative analysis of responses identified additional barriers including a limiting scope and inadequate tools. Approximately half (54.4%) of respondents expressed that additional training would be of value. The themes identified from the survey data suggest that practice-based education would help pharmacists apply skills. In addition, expansion of prescribing authority and strategies addressing remuneration issues may help overcome barriers to pharmacists prescribing within Manitoba.
Trends in antimicrobial resistance patterns of Group A streptococci, molecular basis and implications

Background: Group A streptococcus (GAS) causes a wide variety of diseases ranging from mild skin and soft-tissue infections to severe, life-threatening conditions. A fluctuating trend has been observed in the antibiotic resistance pattern from different parts of the world. The present study was undertaken to determine the prevalence of antibiotic resistance among GAS isolates and the underlying genetic mechanisms. Materials and Methods: Two hundred and six GAS isolates were characterised by antimicrobial susceptibility pattern, macrolide resistance phenotype (double-disc test) and resistance determinants by multiplex polymerase chain reaction. Results: All the isolates were susceptible to penicillin, vancomycin and linezolid. Erythromycin resistance was found in 53% of isolates with inducible macrolide, lincosamide and streptogramin B the predominant phenotype (63%) with ermB the major genetic determinant. Clindamycin resistance was observed in 33% of isolates with all being inducible resistant. Tetracycline resistance was found in 58% of isolates with tetM as the major genetic determinant (97%). Erythromycin and tetracycline co-resistance was found in 39% of tested GAS isolates. Conclusion: The erythromycin and tetracycline resistance in GAS continues to exist at high levels and may be attributed to the over-prescription and use of these antibiotics. Our findings indicate that the use of these antibiotics especially macrolides as empiric therapy in penicillin-allergic patients may not be appropriate.