Miracle-dz/UniFAR-FTUs huggingface dataset:
Rationale and Study Design of Provent-An International Multicenter Observational Study on Practice of Ventilation in Critically Ill Patients without ARDS

Background: Use of lower tidal volumes during mechanical ventilation is associated with reduced morbidity and mortality of Intensive Care Unit (ICU) patients with the Acute Respiratory Distress Syndrome (ARDS). Use of lower tidal volumes could also protect ICU patients without ARDS. While use of higher tidal volumes is strongly discouraged in ARDS patients, guidelines do not yet recommend on tidal volume size in patients not suffering from this complication, resulting in unwanted variable mechanical ventilation settings amongst ICU patients. Purpose: The present study aims to determine ventilation characteristics, including tidal volume size in intubated and mechanically ventilated patients in ICUs in Europe, Australia and the Americas. Ventilation characteristics and outcomes are compared among patients without ARDS, patients at risk for ARDS and patients with mild, moderate or severe ARDS. Methods: The ‘PRatice of VENTilation in critically ill patients without ARDS’ study (PRoVENT) is an international multicenter observational study in critically ill intubated and ventilated ICU patients by the PROVENet (PROtective VENtilation Network) investigators (http://www.provenet.eu/). At least 1,000 patients under invasive mechanical ventilation are included in a time window of 7 days, and followed up to the end of stay in ICU. The primary endpoint is the variability of tidal volume size in ventilated patients in ICUs in Europe, Australia and the Americas. Conclusion: PRoVENT is designed to investigate and compare tidal volume settings in patients without ARDS, patients at risk for ARDS, and patients with mild, moderate or severe ARDS, and to determine the impact of tidal volume size on important clinical endpoints, in particular patients without ARDS. PRoVENT shall provide information on ventilator settings that could be used in future trials of ventilation, especially in ICU patients without or at risk for ARDS (Trial Registration: NCT01868321).
Clostridium difficile Toxins: Mediators of Inflammation

Clostridium difficile is a significant problem in hospital settings as the most common cause of nosocomial diarrhea worldwide. C. difficile infections (CDIs) are characterized by an acute intestinal inflammatory response with neutrophil infiltration. These symptoms are primarily caused by the glucosylating toxins, TcdA and TcdB. In the past decade, the frequency and severity of CDIs have increased markedly due to the emergence of so-called hypervirulent strains that overproduce cytotoxic glucosylating toxins relative to historical strains. In addition, these strains produce a third toxin, binary toxin or C. difficile transferase (CDT), that may contribute to hypervirulence. Both the glucosylating toxins and CDT covalently modify target cell proteins to cause disassembly of the actin cytoskeleton and induce severe inflammation. This review summarizes our current knowledge of the mechanisms by which glucosylating toxins and CDT disrupt target cell function, alter host physiology and stimulate immune responses.
Hepatic artery reconstruction and biliary stricture formation after living donor adult liver transplantation using the left lobe

Biliary complications, including bile leak, biliary stricture, and cholangitis, are seen in 15% to 29% of all cases after living related liver transplantation. We investigate risk factors and discuss the management of biliary complications after living related liver transplantation in adults using left‐lobe grafts. We studied 37 adult patients who underwent living related liver transplantation using left‐lobe grafts. Perioperative variables were evaluated as risk factors for biliary strictures. The overall incidence of biliary complications was 43.2% (16 of 37 patients). Anastomotic strictures occurred in 8 patients, whereas bile leaks and cholangitis occurred in 9 and 8 patients, respectively. Anastomotic stricture was strongly related to a partial artery reconstruction (P < .02) and cholangitis (P < .01). Anastomotic biliary stricture was not associated with bile leak, acute cellular rejection, or infection. Our results suggest that an important risk factor for biliary anastomotic biliary strictures is a partial artery reconstruction. To minimize the risk for biliary anastomotic strictures, we will reconstruct both the middle and left hepatic artery.
Evidence for a complex life cycle and endospore formation in the attached, filamentous, segmented bacterium from murine ileum

Light and electron microscope observations showed that the filamentous, segmented bacterium commonly found attached to the ileal epithelium of rats and mice undergoes a complex life cycle. Filaments comprising up to 90 segments were attached to the microvillous border of absorptive epithelial cells by a specialized terminal holdfast segment. Starting at the free end of the filament and progressing toward the attached end, undifferentiated segments were converted into reproductive or mother segments. Within each mother cell two new holdfast segments developed. As the holdfasts matured, their mother cells degenerated and released them into the intervillar space where they attached, grew, and divided to produce new segmented filaments. Alternately, in some filaments, newly formed but not yet released holdfasts were converted into endospores, which were released in the same manner as holdfasts, presumably to spread the bacterial colony to other members of the rodent population.
Evaluation of Patients With Suspected Ureteral Calculi Using Sonography as an Initial Diagnostic Tool

Objective. The purpose of this study was to evaluate the usefulness of sonography as an initial diagnostic tool in patients with suspected ureterolithiasis. Methods. We performed a prospective study of 318 patients with suspected ureteral stones over a 14‐month period. All patients underwent sonography after fasting for 8 hours and bladder filling. If no cause of the flank pain was found by sonography, computed tomography or intravenous urography was performed immediately to confirm the absence of ureteral stones. Results. We found urolithiasis with sonography in 291 of 296 patients with confirmed urolithiasis. The 5 remaining cases were identified after non–contrast‐enhanced computed tomography (n = 3), intravenous urography (n = 1), or the passage of a stone (n = 1, pregnant patient). We detected 313 calculi in the 291 patients with sonography as follows: 307 ureteral calculi in 285 patients, 5 urinary bladder calculi that were probably passed from the ureter in 5 patients, and 1 urethral calculus. The locations of the 313 calculi in the 291 patients with a sonographic diagnosis were as follows: 21 were in the ureteropelvic junction, 96 in the proximal half of the ureter, 69 in the distal half of the ureter, 121 in the ureterovesical junction, 5 in the urinary bladder, and 1 in the urethra. Hydronephrosis was seen in 200 of the 291 patients with calculi identified by sonography (68.7%). Twinkling artifacts helped confirm the presence of tiny calculi in 184 of the 214 calculi (86%). Conclusions. Sonography can be used as an initial diagnostic tool in patients with suspected ureterolithiasis.
Attachment and Loss: A Test of Three Competing Models on the Association between Attachment-Related Avoidance and Adaptation to Bereavement

It is widely assumed that emotionally avoidant or defensive individuals will have a difficult time adjusting to the loss of a loved one. However, recent research suggests that defensive individuals tend to adapt quite well to loss. Such findings pose a number of challenges to attachment theory—a theory that has traditionally held that emotional avoidance is indicative of poor psychological adjustment. In this article, the authors argue that contemporary models of individual differences in adult attachment allow the derivation of at least three competing hypotheses regarding the relationship between avoidant attachment and adaptation to loss. These hypotheses are tested using two-wave data on 59 bereaved adults. Results indicate that whereas some avoidant individuals (i.e., those who are fearfully avoidant) have a difficult time adapting to the loss of a loved one, other avoidant adults (i.e., those who are dismissingly avoidant) show a pattern of resilience to loss.
Privacy Preserving Deep Computation Model on Cloud for Big Data Feature Learning

To improve the efficiency of big data feature learning, the paper proposes a privacy preserving deep computation model by offloading the expensive operations to the cloud. Privacy concerns become evident because there are a large number of private data by various applications in the smart city, such as sensitive data of governments or proprietary information of enterprises. To protect the private data, the proposed model uses the BGV encryption scheme to encrypt the private data and employs cloud servers to perform the high-order back-propagation algorithm on the encrypted data efficiently for deep computation model training. Furthermore, the proposed scheme approximates the Sigmoid function as a polynomial function to support the secure computation of the activation function with the BGV encryption. In our scheme, only the encryption operations and the decryption operations are performed by the client while all the computation tasks are performed on the cloud. Experimental results show that our scheme is improved by approximately 2.5 times in the training efficiency compared to the conventional deep computation model without disclosing the private data using the cloud computing including ten nodes. More importantly, our scheme is highly scalable by employing more cloud servers, which is particularly suitable for big data.
High Prevalence of Isolates with Reduced Glycopeptide Susceptibility in Persistent or Recurrent Bloodstream Infections Due to Methicillin-Resistant Staphylococcus aureus

ABSTRACT Reduced susceptibility to glycopeptides in methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates is considered a risk factor for failure of glycopeptide therapy. We compared the prevalences of MRSA isolates with reduced glycopeptide susceptibility in patients with versus without persistent or recurrent MRSA bloodstream infections. A retrospective cohort study at the University Hospital of Geneva identified 27 patients with persistent or recurrent clonally related MRSA bacteremic episodes over an 8-year period, which included 208 consecutive nosocomial MRSA bacteremic episodes. Vancomycin and teicoplanin MICs were determined by a modified macrodilution assay allowing improved detection of glycopeptide-intermediate MRSA isolates (GISA), characterized by elevated teicoplanin or/and vancomycin MICs (≥4 μg/ml). For 16 patients (59%), their pretherapy and/or posttherapy MRSA isolates showed elevated teicoplanin MICs, among which 10 (37%) concomitantly displayed elevated vancomycin MICs. In contrast, 11 other patients (41%) were persistently or recurrently infected with non-GISA isolates. In comparison, only 39 (22%) of 181 single isolates from patients with no microbiological evidence of persistent or recurrent infections showed elevated teicoplanin MICs, among which 14 (8%) concomitantly displayed elevated vancomycin MICs. Clinical, microbiological, and pharmacokinetic variables for patients persistently or recurrently infected with GISA or non-GISA isolates were similar. Bacteremic patients with a poor response to glycopeptide therapy had a 2.8-fold- and 4.8-fold-higher rates of MRSA isolates displaying elevated teicoplanin and vancomycin MICs, respectively, than patients with single isolates (P < 0.0001). Detection of elevated teicoplanin MICs may help to predict a poor response to glycopeptide therapy in MRSA bacteremic patients.
Predicting Head Start Parent Involvement in An Alcohol and Other Drug Prevention Program

This study examined Health Belief Model predictors of parent involvement with preschool children in an alcohol and other drug (AOD) prevention program. Over 300 Head Start parents were invited to participate in BABES (Beginning Alcohol and Addictions Basic Education Studies) with their children once a week for 7 weeks. Two hundred parents completed self-report instruments prior to participation in BABES. Previous classroom involvement, barriers, county, and race predicted high attendance (3 to 7 lessons). AOD use severity, benefits, and role modeling predicted low attendance (1 to 2 lessons). Further research involving manipulation of external cues, parent involvement in nonclassroom settings, and race-homogeneous samples is recommended.
Oral transit time: a critical review of the literature

Introduction Oral transit time is one of the parameters observed during the clinical assessment of the swallowing function. The importance of this parameter is due to its impact on the total duration of a meal, whose consequence can be an unfavorable nutritional prognostic. Objective To document scientific papers that measure oral transit time in healthy subjects. Method The review followed the steps proposed by the Cochrane Handbook. The search was done via the PubMed database through the use of descriptors related to the oral phase of swallowing, as well as to types of food consistency. Results The articles on the theme had different definitions for oral transit time, as well as heterogeneity of tested volumes, age and gender of the participants. The times found varied from 0.35 s to 1.54 s for liquids, from 0.39 s to 1.05 s for pasty foods and from 1 s to 12.8 s for solid foods. Also, regardless of volume or consistency, oral transit time in elderly people is significantly longer than in adults. Conclusion There's no consensus in the literature about oral transit time in healthy subjects. However, this parameter should be valued during the assessment of the swallowing function due to its negative impact on the dynamics of swallowing, which can cause high energy expenditure during feeding.
The Ancient Tradition on the Identity of Antiphon

N MANY Antiphons known from antiquity, two fifthcentury figures are sometimes thought to be the same person: Antiphon of Rhamnus, an orator and a leader of the oligarchic coup in 411, and 'Antiphon the Sophist', one of Socrates' interlocutors in Xenophon (M em. 1.6) to whom are often attributed the works On Truth, On Concord, and Politicus. 1 The separatist case has usually been based on the papyrus fragments of On Truth, but the most recent separatist argument, by Gerard Pendrick,2 deals almost entirely with the ancient tradition. He concedes that "the majority of ancient opinion is unitarian" (59), but he accords this fact little weight and presents instead a selective discussion of ancient authors who, in his view, support a separatist position. The purpose of this paper is to offer a more comprehensive assessment of the ancient tradition and to show that ancient opinion was more strongly unitarian than Pendrick implies. 3 As far as we can tell, the only separatist views expressed in antiquity were based on stylistic criteria alone, the inadequacy of which is evident, and a unitarian position is taken for granted
Las tablas y gráficos estadísticos como objetos culturales

Ademas de la presencia constante de informacion estadistica en los medios de comunicacion, muchos organismos nacionales e internacionales proporcionan en la actualidad acceso libre a sus bases de datos de informacion estadistica a traves de Internet. Surge como consecuencia la demanda social de educacion estadistica que permita comprender e interpretar esta informacion en la toma de decisiones. En este trabajo sintetizamos la investigacion que describe las competencias requeridas en la construccion y lectura critica de tablas y graficos estadisticos.
Narrow Grass Hedge Effects on Nutrient Transport Following Compost Application

The placement of stiff-stemmed grass hedges on the contour along a hillslope has been shown to decrease nutrient transport in runoff. This study was conducted to measure the effectiveness of a narrow grass hedge in reducing runoff nutrient transport from plots with a range of soil nutrient values. Composted beef cattle manure was applied at dry weights of 0, 68, 105, 142, and 178 Mg ha -1 to a silty clay loam soil and then incorporated by disking. Soil samples were collected 243 days later for analysis of water-soluble phosphorus (WSP), Bray and Kurtz No. 1 phosphorus (Bray-1 P), NO3-N, and NH4-N. Three 30 min simulated rainfall events, separated by 24 h intervals, were then applied. The transport of dissolved phosphorus (DP), total P (TP), NO3-N, NH4-N, total nitrogen (TN), runoff, and soil erosion were measured from 0.75 m wide × 4.0 m long plots. Compost application rate significantly affected soil measurements of WSP, Bray-1 P, and NO3-N content. The transport of DP, TP, NO3-N, NH4-N, TN, runoff, and soil erosion was reduced significantly on the plots with a grass hedge. Mean runoff rates on the hedge and no-hedge treatments were 17 and 29 mm, and erosion rates were 0.12 and 1.46 Mg ha -1 , respectively. Compost application rate significantly affected the transport of DP, TP, and NO3-N in runoff. The experimental results indicate that stiff-stemmed grass hedges, planted at selected downslope intervals, can significantly reduce the transport of nutrients in runoff from areas with a range of soil nutrient values.
Spatial and seasonal variation of the gonad index of Diadema antillarum (Echinodermata:Echinoidea) in the Canary Islands

Diadema antillarum Philippi occurs in high density populations in the Canary Islands, creating extensive barren areas. During one year we determined seasonal changes in the algal abundance and population densities, test diameter, gut contents and gonad index of sea urchins in two localities (Abades and Boca Cangrejo). Boca Cangrejo shows higher algae cover and species richness than Abades. The sea urchin population at Abades had a higher density and smaller urchins than Boca Cangrejo. Boca Cangrejo sea urchins showed higher specific richness in gut contents than Abades urchins. The sea urchin population at Abades did not have a clearer reproductive periodicity or higher gonad index than the Boca Cangrejo population. Temporal and spatial changes in gonad periodicity of Diadema antillarum are attributed, at least in part, to benthic food availability (algal cover and algal species number) and intra-specific competition.
High voltage studies of inverted-geometry ceramic insulators for a 350 kV DC polarized electron gun

Jefferson Lab is constructing a 350 kV direct current high voltage photoemission gun employing a compact inverted-geometry insulator. This photogun will produce polarized electron beams at an injector test facility intended for low energy nuclear physics experiments, and to assist the development of new technology for the Continuous Electron Beam Accelerator Facility. A photogun operating at 350kV bias voltage reduces the complexity of the injector design, by eliminating the need for a graded-beta radio frequency "capture" section employed to boost lower voltage beams to relativistic speed. However, reliable photogun operation at 350 kV necessitates solving serious high voltage problems related to breakdown and field emission. This study focuses on developing effective methods to avoid breakdown at the interface between the insulator and the commercial high voltage cable that connects the photogun to the high voltage power supply. Three types of inverted insulators were tested, in combination with two electrode configurations. Our results indicate that tailoring the conductivity of the insulator material, and/or adding a cathode triple-junction screening electrode, effectively serves to increase the hold-off voltage from 300kV to more than 375kV. Electrostatic field maps suggest these configurations serve to produce a more uniform potential gradient across the insulator.
Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells

ABSTRACT Class B scavenger receptors (SR-Bs) bind lipoproteins and play an important role in lipid metabolism. Most recently, SR-B type I (SR-BI) and its splicing variant SR-BII have been found to mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells. In this study, we demonstrate that SR-BI is a key host factor required for hepatitis C virus (HCV) uptake and cross-presentation by human dendritic cells (DCs). Whereas monocytes and T and B cells were characterized by very low or undetectable SR-BI expression levels, human DCs demonstrated a high level of cell surface expression of SR-BI similar to that of primary human hepatocytes. Antibodies targeting the extracellular loop of SR-BI efficiently inhibited HCV-like particle binding, uptake, and cross-presentation by human DCs. Moreover, human high-density lipoprotein specifically modulated HCV-like particle binding to DCs, indicating an interplay of HCV with the lipid transfer function of SR-BI in DCs. Finally, we demonstrate that anti-SR-BI antibodies inhibit the uptake of cell culture-derived HCV (HCVcc) in DCs. In conclusion, these findings identify a novel function of SR-BI for viral antigen uptake and recognition and may have an important impact on the design of HCV vaccines and immunotherapeutic approaches aiming at the induction of efficient antiviral immune responses.
Histomorphometric and whole-genome expression analysis of peri-implant soft tissue healing: a comparison of flapless and open surgery.

PURPOSE The structure of peri-implant soft tissue that is regenerated after flapless and flap surgery has been shown to differ. However, its underlying mechanisms are relatively unknown. The present study sought to identify differences in the inflammatory cell infiltration and expression of gene transcripts during transmucosal healing between the two approaches with two different implant designs. MATERIALS AND METHODS All mandibular premolars were removed from 12 minipigs. One month later, four implants (two NobelReplace Tapered Groovy and two NobelPerfect Groovy, Nobel Biocare) were placed in each quadrant. One quadrant was randomized to flapless insertion, while the other was chosen for flap surgery in each animal. Following 1, 2, 4, and 12 weeks of transmucosal implant healing, biopsy specimens were retrieved from the peri-implant soft tissue according to a standardized procedure to avoid crossover effects. Samples were subjected to a leukocyte count and a gene expression analysis. RESULTS When the flapless placement technique was used, leukocyte influx in the peri-implant soft tissue was significantly smaller compared to open surgery for both implant designs. Gene expression analysis revealed significant overexpression of molecules associated with detoxification and reepithelialization in the flapless group. In contrast, myofibroblast-associated gene transcripts were significantly enriched in the flap surgery group. CONCLUSIONS The present data indicate perpetuation of inflammatory reactions as well as increased fibrotic scar tissue deposition in the peri-implant area following implant placement by the flap approach. Flapless implant insertion results in less inflammation and early reepithelialization, providing the potential for the formation of a fully functioning as well as esthetically preferable peri-implant soft tissue collar.