Miracle-dz/UniFAR-FTUs huggingface dataset:
Microwave ablation in treating intrahepatic recurrence of hepatocellular carcinoma after liver transplantation: An analysis of 11 cases

Abstract Purpose: This study was designed to evaluate the efficacy and safety of microwave ablation (MWA) in the treatment of intrahepatic recurrence of hepatocellular carcinoma (HCC) after liver transplantation. Materials and methods: Between October 2008 and August 2014, a total of 11 cases with 19 lesions were enrolled. All the subjects had confirmed HCC recurrence after liver transplantation by at least two types of enhanced imaging. Real-time monitoring and small ethanol doses were used as an additional technique to assist with ablation. Contrast imaging was performed to evaluate the technique efficacy. The technique efficacy rate, local tumour progression rate, 3, 6, 9, 12, 18 and 24 months survival rates, and the incidence of complications were comprehensively analysed. Results: The follow-up period ranged from 5–33 months. All tumours achieved full ablation. The first MWA technique efficacy rate was 84.2% (16/19), while the second technique efficacy rate was 100%. Local tumour progression was identified in three cases (15.8%) at 1, 3 and 7 months after MWA. The 3, 6, 9, 12, 18 and 24 months accumulative survival rates were 90.9%, 81.8%, 71.6%, 51.5%, 30.7% and 15.3%, respectively, the average survival time was 17.3 months (3.5–33 months). Mild side effects included five patients (45.4%) with fevers, three with (27.3%) nausea and vomiting, five (45.4%) with local pain, and eight (72.7%) with increased blood transaminase levels; no serious complications occurred. Conclusion: MWA treatment is a promising technique for intrahepatic recurrence after liver transplantation without serious complications or side effects.
Arterial blood pressure and left ventricular hypertrophy in haemodialysis patients

Objective To test the hypothesis that there is an association between arterial blood pressure and left ventricular hypertrophy and patterns of ventricular geometry, defined echocardiographically, in a group of stable haemodialysis patients with a low prevalence of extrarenal diseases. Design and methods Patients with end-stage renal failure treated by regular haemodialysis (aged 44.3 ± 12.9 years, n = 103, among whom 52 men and 23 blacks, dialysis duration 49.8 ± 35.3 months) were subjected to echo-cardiographic evaluation (M-mode, bidimensional and Doppler) on the day preceding dialysis. The average of all predialysis blood pressure determinations during the 3 months preceding the tests (34–38 determinations in each patient) were used as baseline data. Univariate and multivariate tests were used to assess the main variables associated with echocardiographically defined cardiac alterations and with patterns of ventricular geometry. Results The systolic blood pressure was significantly associated with the left ventricular mass index and was significantly and independently correlated with left ventricular hypertrophy, posterior wall hypertrophy, left ventricle dilation and increased relative wall thickness. Other significant correlations were between the haematocrit level and left ventricular hypertrophy and between age and altered systolic and diastolic functions. Concentric ventricular hypertrophy was observed only in patients with a history of hypertension, whereas the prevalence of normal geometry was higher in patients without a history of hypertension. Conclusion The systolic blood pressure is an important factor influencing the occurrence of left ventricular hypertrophy in haemodialysis patients and also affects the left ventricle geometry in this population.
Does vertical separation always make sense

In spite of the fact that the European Commission believes that European Union (EU) member states should enforce full separation of infrastructure from train operations, an analysis of experience so far, as presented in this article, suggests that security of funding is far more important for the countries of central and eastern Europe and that the benefits are not proven. The study compared available data for EU member states, such as level of competition in the rail freight market; growth in freight and passenger markets; and rail's share of the total freight and passenger traffic market in selected countries. In conclusion, the authors believe that there is no evidence to support the requirement to fully separate infrastructure from train operations. This work should provide a guide to possible future legislation.
Does Low Job Satisfaction Lead to Job Mobility?

This paper seeks to analyse the role of job satisfaction and actual job change behaviour. The analysis is based on the European Community Household Panel (ECHP) data for Danish families 1994-2000. The results show that inclusion of job satisfaction, which is a subjective measure, does improve the ability to predict actual quit behaviour: Low overall job satisfaction significantly increases the probability of quit. Various job satisfaction domains are ranked according to their ability to predict quits. Satisfaction with Type of Work is found to be the most important job characteristic while satisfaction with Job Security is found to be insignificant. These results hold across age, gender and education sub-groups and are opposed to results for UK, where job security is found to be the most important job domain. This discrepancy between UK and Denmark might be due to differences in unemployment insurance benefits and indicates that there are “invisible” benefits inherited in the welfare state insurance system because employees in Denmark don’t worry about job security.
Can subsidies be better targeted

Reform of the water and sanitation sector is occurring in many countries, and offers the potential to improve services to all. Of particular concern, however, is the situation of the poor, and reform must be designed so that they receive increased access to affordable services. A key issue in this regard is water pricing, which is one of the main variables affecting the distribution of benefits between different stakeholders. However, experience shows that water pricing, and the subsidies which are often delivered through water tariffs, can be a source of major inefficiencies in the sector. While affordability has been one of the prime concerns of those setting tariffs and designing subsidies, there may be significant flaws in many common pricing strategies and subsidy delivery mechanisms. Rather than providing affordable water to the poor, these may in facts be leading to financial unsustainability of utilities, lack of access to services, and inequity. The reform process provides the opportunities to rationalize and reconsider the design of tariff and subsidy structures, and seek new ones which may provide better results.
Physiology of Normal Esophageal Motility

The esophagus consists of 2 different parts. In humans, the cervical esophagus is composed of striated muscles and the thoracic esophagus is composed of phasic smooth muscles. The striated muscle esophagus is innervated by the lower motor neurons and peristalsis in this segment is due to sequential activation of the motor neurons in the nucleus ambiguus. Both primary and secondary peristaltic contractions are centrally mediated. The smooth muscle of esophagus is phasic in nature and is innervated by intramural inhibitory (nitric oxide releasing) and excitatory (acetylcholine releasing) neurons that receive inputs from separate sets of preganglionic neurons located in the dorsal motor nucleus of vagus. The primary peristalsis in this segment involves both central and peripheral mechanisms. The primary peristalsis consists of inhibition (called deglutitive inhibition) followed by excitation. The secondary peristalsis is entirely due to peripheral mechanisms and also involves inhibition followed by excitation. The lower esophageal sphincter (LES) is characterized by tonic muscle that is different from the muscle of the esophageal body. The LES, like the esophageal body smooth muscle, is also innervated by the inhibitory and excitatory neurons. The LES maintains tonic closure because of its myogenic property. The LES tone is modulated by the inhibitory and the excitatory nerves. Inhibitory nerves mediate LES relaxation and the excitatory nerves mediate reflex contraction or rebound contraction of the LES. Clinical disorders of esophageal motility can be classified on the basis of disorders of the inhibitory and excitatory innervations and the smooth muscles.
Development and Optimization of Methods for Using Sex Pheromone for Monitoring the Mealybug Planococcus ficus (Homoptera: Pseudococcidae) in California Vineyards

Abstract The sex pheromone of the vine mealybug Planococcus ficus Signoret has been identified as a single component, lavandulyl senecioate. Racemic lavandulyl senecioate was as attractive to male mealybugs as the insect-produced (S)-enantiomer, indicating that the unnatural enantiomer is not inhibitory. Lavandulol, which also was found in extracts from virgin females, antagonized attraction of males at higher doses. Rubber septum lures loaded with 10- to 1,000-μg doses of the pheromone were equally attractive, and lures loaded with 100 μg of racemic pheromone remained attractive for at least 12 wk under field conditions. Delta traps were more effective than double-sided sticky cards and minimized captures of nontarget insects. Pheromone-baited traps had an effective range of at least 50 m. Comparison of visual sampling methods and sampling of males with pheromone-baited traps revealed that trap catches were significantly correlated with the results from visual sampling methods, and with economic damage.
Hunger effects on foraging responses to perceptual cues in immature and adult wolf spiders (Lycosidae)

The wolf spider, Schizocosa ocreata (Hentz), varies foraging patch residence time in the presence of different sensory cues from prey, even without food rewards. This study examines the influence and interaction of hunger state, age and sex on the use of different types of sensory information to determine foraging patch sampling duration. In a series of two-chambered artificial foraging patches, I tested 26 S. ocreata once as immatures, and again as adults, under two hunger states (satiated and 7 days without food). Patches varied in the type of sensory information provided by live prey (crickets) as follows: visual cues alone; vibratory cues alone; combined visual/vibratory cues; and control (no prey). Without feeding in patches, the type of sensory stimuli available from prey strongly affected patch residence time, with spiders using primarily visual rather than vibratory cues. Hunger level as a main effect had no influence on residence time, but hunger state did mediate the importance of visual or vibratory information. Significant age- and sex-related differences in patch residence time in the presence of different sensory cues were found.These data suggest that ontogenetic and sex-specific foraging strategies are influenced by use of prefeeding perceptual cues rather than hunger state in wolf spiders. Copyright 1999 The Association for the Study of Animal Behaviour.
Do Insiders Use Investor Relations for Their Personal Benefit? An Empirical Investigation of Hong and Huang (2005)

Investor relations (IR) are costly activities, and a widely held view is that companies undertake them to increase share price over time. However, Hong and Huang (2005) assert that companies undertake IR for the personal benefit of company insiders with large ownership stakes. We test Hong and Hong (2005) empirically, specifically by investigating the association between the IR activities of newly listed companies and insider equity ownership, as well as insider sales. The results support Hong and Huang’s predictions where newly listed companies are more likely to engage in broker presentations when insiders have a valuable ownership stake. Furthermore, companies where insiders sell a large portion of their shares undertake different group presentations. The results suggest that insiders in these companies contemplate their personal incentives when setting IR policy such that IR is not necessarily undertaken for the benefit of all shareholders.
Simulation of large circular antenna arrays using the Array Scanning Method

In this paper we present a numerical method for the simulation of large circular antenna arrays using the Array Scanning Method (ASM) applied with the method of moments to reduce the mathematical problem from an (N⋆M)x(N⋆M) system to N (MxM) systems where N is the number of elements in the array and M is the number of basis functions in the antenna mesh. A link will be established between the ASM and DFT-based methods for circulant matrices. This technique will be applied to study the resonance modes of a circular array made of 90 dipoles, and we will use it to study a circular array of connected wideband tapered-slot antennas.
Enhancement of morphine antinociception by a CCKB antagonist in mice is mediated via opioid delta receptors.

This study investigated the possible involvement of opioid delta receptors in the modulation of morphine antinociceptive potency produced by L365,260 a CCKB antagonist. Intracerebroventricular (i.c.v.), intratheoal (i.th.) or subcutaneous (s.c.) L365,260 alone did not produce any antinociceptive actions in the mouse warm-water tail-nick test. Treatment with L365,260 by any of these routes produced a leftward shift of the corresponding morphine dose-effect curve that was blocked by pretreatment with a receptor selective dose of s.c. naltrindole, an opioid delta receptor antagonist. Pretreatment with i.c. v. antisera to [Leu5]enkephalin also blocked the leftward displacement of the i.c. v. morphine dose-effect curve resulting from L365,260 but did not directly alter the i.c. v. morphine dose-effect curve; antisera to [Met5]enkephalin did not alter the effects of morphine or the modulation of morphine antinociception produced by L365,260. Repeated pretreatment with L365,260 resulted in a progressive decrease in the magnitude of the morphine modulatory action (i.e., L365,260 "tolerance"). In these "L365,260-tolerant" mice, the dose-effect curve for i.c. v. [D-Ala2, Glu4]deltrophin (a selective delta agonist) was displaced to the right by approximately 8.2-fold. The i.c. v. administration of [Leu5]enkephalin produced a leftward displacement of the i.c. v. morphine dose-effect curve that diminished after repeated administration (i.e., [Leu5]enkephalin "tolerance"). In "[Leu5]enkephalin-tolerant" mice, L365,260 failed to produce the leftward shift of the morphine dose-effect curve seen in control animals. That is, two-way antinociceptive cross-tolerance was observed between an opioid delta agonist and a CCKB receptor antagonist. Intracerebroventricular thiorphan, a peptidase inhibitor, did not elicit antinociception directly. Co-administration of thiorphan with L365,260 elicited significant antinociception that was blocked by naltrindole or antisera to [Leu5]enkephalin; antisera to [Met5]enkephalin had no effect. Repeated administration of i.c. v. [D-Ala2, Glu4]deltorphin resulted in a progressively decreasing antinociceptive effect (i.e., [D-Ala2, Glu4]deltorphin "tolerance"). In "[D-Ala2, Glu4]deltorphin-tolerant" mice, the thiorphan/L365,260 antinociceptive effect was inhibited. Collectively, these data suggest that CCK interacts at the CCKB receptor to inhibit tonically the release and/or availability of an endogenous substance acting at opioid delta receptors. The subsequent enhancement of morphine antinociceptive potency may reflect the well-known modulation of morphine antinociception produced by opioid delta receptor agonists. In this case, the latter may be [Leu5]enkephalin or a [Leu5]enkephalin-like substance.
The effectiveness of environmental advertising: the role of claim type and the source country green image

This study examines how environmental claim type may affect the communication effectiveness of environmental advertising, and how the source country's green image may moderate the claim type-effectiveness relationship. By applying a 4 × 2 factorial research design to investigate 800 subjects in Guangzhou, China, the study demonstrates that environmental claim type and the source country's green image both exert a significant main effect on the effectiveness. This study also demonstrates that these two factors in combination exhibit a significant interaction effect on the effectiveness. These empirical findings remind marketers of the importance of adopting a situational perspective when designing their environmental claims. When deciding which environmental claim type they should apply, marketers should, among others, also take into consideration how their target customers actually perceive the eco-friendliness of the relevant source country. Given consumers' increasing scepticism about products with alleged eco-friendly attributes in the wake of an influx of various misleading green advertisements, environmental claims which are incongruent with their extant perceptions are unlikely to be effective.
Biofilm Production by Isolates of Candida Species Recovered from Nonneutropenic Patients: Comparison of Bloodstream Isolates with Isolates from Other Sources

ABSTRACT Biofilm production has been implicated as a potential virulence factor of some Candida species responsible for catheter-related fungemia in patients receiving parenteral nutrition. We therefore compared clinical bloodstream isolates representing seven different Candida species to each other and to those from other anatomical sites for the capacity to form biofilms in glucose-containing medium. Potential associations between the capacity to form biofilms and the clinical characteristics of fungemia were also analyzed. Isolates included the following from nonneutropenic patients: 101 bloodstream isolates (35 C. parapsilosis, 30 C. albicans, 18 C. tropicalis, 8 C. glabrata, and 10 other Candida species isolates) and 259 clinical isolates from other body sites (116 C. albicans, 53 C. glabrata, 43 C. tropicalis, 17 C. parapsilosis, and 30 other Candida species isolates). Organisms were grown in Sabouraud dextrose broth (SDB) containing a final concentration of 8% glucose to induce biofilm formation, as published previously. Biofilm production was determined by both visual and spectrophotometric methods. In this medium, biofilm production by C. albicans isolates was significantly less frequent (8%) than that by non-C. albicans Candida species (61%; P < 0.0001). The overall proportion of non-C. albicans Candida species isolates from the blood that produced biofilms was significantly higher than that of non-C. albicans Candida isolates obtained from other sites (79% versus 52%; P = 0.0001). Bloodstream isolates of C. parapsilosis alone were significantly more likely to be biofilm positive than were C. parapsilosis isolates from other sites (86% versus 47%; P = 0.0032). Non-C. albicans Candida species, including C. parapsilosis, were more likely to be biofilm positive if isolates were derived from patients whose candidemia was central venous catheter (CVC) related (95%; P < 0.0001) and was associated with the use of total parenteral nutrition (TPN) (94%; P < 0.005). These data suggest that the capacity of Candida species isolates to produce biofilms in vitro in glucose-containing SDB may be a reflection of the pathogenic potential of these isolates to cause CVC-related fungemia in patients receiving TPN.
Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection.

PURPOSE To compare the effectiveness of radio-frequency (RF) thermal ablation with that of percutaneous ethanol injection (PEI) for the treatment of small hepatocellular carcinoma (HCC) in patients with cirrhosis. MATERIALS AND METHODS A series of 102 patients with hepatic cirrhosis and either single HCC 5 cm in diameter or smaller or as many as three HCCs each 3 cm or smaller (overall number of lesions, 142) randomly received either RF ablation (n = 52) or PEI (n = 50) as the sole first-line anticancer treatment. Mean follow-up was 22.9 months +/- 9.4 (SD) in the RF group and 22.4 months +/- 8.6 in the PEI group. Prognostic value of treatment techniques was assessed with univariate and multivariate Cox proportional hazards regression models. RESULTS One- and 2-year survival rates were 100% and 98% in the RF group and 96% and 88% in the PEI group, respectively (univariate relative risk [RR] = 0.20; 95% CI: 0.02, 1.69; P =.138). One- and 2-year local recurrence-free survival rates were 98% and 96% in the RF group and 83% and 62% in the PEI group, respectively (univariate RR = 0.17; 95% CI: 0.06, 0.51; P =.002). One- and 2-year event-free survival rates were 86% and 64% for the RF group and 77% and 43% for the PEI group, respectively (univariate RR = 0.48; 95% CI: 0.27, 0.85; P =.012). RF treatment was confirmed as an independent prognostic factor for local recurrence-free survival rates with multivariate analysis (adjusted RR = 0.20; 95% CI: 0.05, 0.73; P =.015). CONCLUSION RF ablation is superior to PEI with respect to local recurrence-free survival rates.
Simple Voltage Balancing Approach for CHB Multilevel Inverter Considering Low Harmonic Content Based on a Hybrid Optimal Modulation Strategy

This paper presents an effective hybrid optimal modulation technique for a cascaded H-bridge (CHB) multilevel inverter. The introduced method is generalized optimal pulsewidth modulation, which can be extended to any m-level CHB multilevel inverter operating at any switching frequency. The presented hybrid optimal modulation strategy includes the pattern exchange and optimal modulation techniques. In the optimal modulation technique, the hybrid interior-point algorithm, which is more flexible and efficient than conventional optimization techniques, is applied. The proposed hybrid optimal modulation strategy yields balanced units' output fundamental voltages, and low total harmonic distortion without the need for additional stabilizers. The performance of the proposed modulation strategy is verified by simulation studies and experimental results using a five-level CHB single-phase multilevel inverter.