Miracle-dz/UniFAR-FTUs huggingface dataset:
Herpetiform napkin dermatitis: napkin dermatitis simulating an acute herpes simplex infection

E L O N , J . , JACOBS, G.P., WITZTUM, E . & GREENBLATT, C . L . (1984) Dfve]opment of topical treatment for cutaneous leishmaniasis caused by Leishmania major in experimental animals, Amimicrobiat Agents & Chemotherapy, 26,745. E L O N , J . , WEINRALXH, L . , LIVISHIN, R . , EVAN-PAZ, Z . & JACOBS, G . P . (1985) Topical treatment of recurrent cutaneous leishmaniasis with ointment containing paromnmycin and methylbenzethonium chloride. British Medical Journal, 291, 704. EVANS, D . A . (1978) Kinetoplastida. In: Aiethods of Cultivating Parasites in vitro (Ed. by A.E.R.Taylor and J.R.Baker), p.55. Academic Press, London. EVANS, D.A,, LANHAM, S , M . , BALDWIN, C.I. & PETERS, W . (1984) The isolation and isoenzyme characterization of Leishmania braziliensis subsp, from patients with cutaneous leishmaniasis acquired in Belize. Transactions, of the Royal Society of Tropical Medicine and Hygiene, 78, 35. GODFREY, D , G . & KILGOCR, V, (1976) Enzyme electrophoresis in characterizing the causative organism of Gambian trypanosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 70, 219, PETERS, W . , EVANS, D , A , & LANHAM, S , M . (1983) Importance of parasite identification in cases of leishmaniasis. Journal of the Royal Society of Medicine, 76, 540, Rioux, J,A,, LANOTTE, G , , MAAZOUN, R . , PERELLO, R, & PRATLONG, F . ;I98O") Leishmania j'w/a'iiMwNicolle, 1908, Agent du bouton d'Orient autochtone, A propos de i'identification biochemique de deux souches isolees dans les Pyrenees-Orientaies, Comptes Rendus des Seances de I'Acaderme des Sciences Paris t.291 f 2j Octobre 198OJ Serie D-
Changes in Colorectal Cancer Screening Knowledge, Behavior, Beliefs, Self-Efficacy, and Barriers among Community Health Clinic Patients after a Health Literacy Intervention.

OBJECTIVE The objective in this pre- and post-survey assessment was to compare the effectiveness of a health literacy-directed intervention designed to increase knowledge, beliefs, barriers, self-efficacy and behavior associated with CRC screening with FOBT among patients cared for in predominantly rural community clinics and the change in these characteristics over the first 15 months after enrolling in a study designed to assess screening strategies. METHODS Between 2008 and 2011, a quasi-experimental intervention was conducted in 8 predominantly rural Federally Qualified Health Centers. Patients were orally administered a 15-minute survey at enrollment by a clinic research assistant (RA) and at 15 months by phone by a central RA. Participants included 428 community clinic patients aged 50-85 (mean 58.5); the majority (79%) were female, 69% were African American, and 54% had limited health literacy. RESULTS There was significant improvement across all groups with the number of patients reporting they had been given information /education on CRC testing (p<.0001), been given an FOBT kit (p<.0001), and completed an FOBT (p<.0001) with significant improvement in having a doctor recommendation in all groups except usual care. Confidence in an FOBT's potential to decrease chances of dying from CRC improved across all groups as well (p<0.002). In addition, patients 'belief that they would get CRC in their lifetime' decreased across all groups post-intervention (p<0.03) as did their worry that they may find out they have CRC (p<0.04). CONCLUSION Overall these low income FQHC patients who were not up-to-date with screening had heard of CRC screening, had positive attitudes toward screening and wanted to know if they had cancer. Results demonstrate the value of giving patients a recommendation and a kit; patients in all groups reported significant increases at 15 months in completing CRC screening (>83%) as confirmed by study records.
Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes.

In recent years, several surveys have highlighted the presence of the rodent carcinogen furan in a variety of food items. Even though the evidence of carcinogenicity of furan is unequivocal, the underlying mechanism has not been fully elucidated. In particular, the role of genotoxicity in furan carcinogenicity is still not clear, even though this information is considered pivotal for the assessment of the risk posed by the presence of low doses of furan in food. In this work, the genotoxic potential of furan in vivo has been investigated in mice, under exposure conditions similar to those associated with cancer onset in the National Toxicology Program long-term bioassay. To this aim, male B6C3F1 mice were treated by gavage for 4 weeks with 2, 4, 8 and 15 mg furan/kg b.w. /day. Spleen was selected as the target organ for genotoxicity assessment, in view of the capability of quiescent splenocytes to accumulate DNA damage induced by repeat dose exposure. The induction of primary DNA damage in splenocytes was evaluated by alkaline single-cell gel electrophoresis (comet assay) and by the immunofluorescence detection of foci of phosphorylated histone H2AX (gamma-H2AX). The presence of cross-links was probed in a modified comet assay, in which cells were irradiated in vitro with gamma-rays before electrophoresis. Chromosome damage was quantitated through the detection of micronuclei in mitogen-stimulated splenocytes using the cytokinesis-block method. Micronucleus induction was also assessed with a modified protocol, using the repair inhibitor 1-beta-arabinofuranosyl-cytosine to convert single-strand breaks in micronuclei. The results obtained show a significant (P < 0.01) increase of gamma-H2AX foci in mitogen-stimulated splenocytes of mice treated with 8 and 15 mg furan/kg b.w. and a statistically significant (P < 0.001) increases of micronuclei in binucleated splenocytes cultured in vitro. Conversely, no effect of in vivo exposure to furan was observed when freshly isolated quiescent splenocytes were analysed by immunofluorescence and in comet assays, both with standard and radiation-modified protocols. These results indicate that the in vivo exposure to furan gives rise to pre-mutagenic DNA damage in resting splenocytes, which remains undetectable until it is converted in frank lesions during the S-phase upon mitogen stimulation. The resulting DNA strand breaks are visualized by the increase in gamma-H2AX foci and may originate micronuclei at the subsequent mitosis.
Anticancer Potentials of Peptides of Coelomic Fluid of Earthworm Eudrilus eugeniae

Production of compounds of Pharmacological importance from earthworms is a novel area that has gained importance in many of the South East Asian countries in modern day medicine termed as vermiceuticals. Earthworms were maintained in plastic tubs containing decomposed organic matter that served as substrate and their feed. Cancer cell were cultured according to standard cells culture method. The cancer cells were treated with different concentrations of proteins from coelomic fluid of Eudrilus eugeniae to study the concentration effect on cytotoxicity using MTT assay. The result revealed that the coelomic fluid of Eudrilus eugeniae induced cell death in 48hrs and the activity was concentration dependent. In the present study Cytotoxic effect of coelomic fluid from Eudrilus eugeniae was studied on HeLa cell, Colon cancer cells, WBC malignant tumor cells and Brain tumor cells. This confirms the presence of cytotoxic molecules in the coelomic fluid of earthworms. This work suggests that some of the coelomic fluid components might be useful for pharmaceutical applications in the treatment of cancer.
Population pharmacokinetic analysis of cilostazol in healthy subjects with genetic polymorphisms of CYP3A5, CYP2C19 and ABCB1.

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * The interindividual variability of the pharmacokinetic parameters of cilostazol is relatively large. * Cilostazol undergoes extensive hepatic metabolism via the P450 enzymes, primarily CYP3A and, to a lesser extent, CYP2C19. * Indeed, <1% of the administered dose of cilostazol is excreted unchanged in the urine. WHAT THIS STUDY ADDS * A population pharmacokinetic analysis of cilostazol was conducted to evaluate the impact of CYP3A, CYP2C19 and ABCB1 polymorphisms on cilostazol disposition in vivo. * Genetic polymorphisms of CYP3A5 and CYP2C19 explain the substantial interindividual variability in the pharmacokinetics of cilostazol. * ABCB1 genotypes do not to appear to be associated with the disposition of cilostazol. AIMS To investigate the influence of genetic polymorphisms in the CYP3A5, CYP2C19 and ABCB1 genes on the population pharmacokinetics of cilostazol in healthy subjects. METHODS Subjects who participated in four separate cilostazol bioequivalence studies with the same protocols were included in this retrospective analysis. One hundred and four healthy Korean volunteers were orally administered a single 50- or 100-mg dose of cilostazol. We estimated the population pharmacokinetics of cilostazol using a nonlinear mixed effects modelling (nonmem) method and explored the possible influence of genetic polymorphisms in CYP3A (CYP3A5*3), CYP2C19 (CYP2C19*2 and CYP2C19*3) and ABCB1 (C1236T, G2677T/A and C3435T) on the population pharmacokinetics of cilostazol. RESULTS A two-compartment model with a first-order absorption and lag time described the cilostazol serum concentrations well. The apparent oral clearance (CL/F) was estimated to be 12.8 l h(-1). The volumes of the central and the peripheral compartment were characterized as 20.5 l and 73.1 l, respectively. Intercompartmental clearance was estimated at 5.6 l h(-1). Absorption rate constant was estimated at 0.24 h(-1) and lag time was predicted at 0.57 h. The genetic polymorphisms of CYP3A5 had a significant (P < 0.001) influence on the CL/F of cilostazol. When CYP2C19 was evaluated, a significant difference (P < 0.01) was observed among the three genotypes (extensive metabolizers, intermediate metabolizers and poor metabolizers) for the CL/F. In addition, a combination of CYP3A5 and CYP2C19 genotypes was found to be associated with a significant difference (P < 0.005) in the CL/F. When including these genotypes, the interindividual variability of the CL/F was reduced from 34.1% in the base model to 27.3% in the final model. However, no significant differences between the ABCB1 genotypes and cilostazol pharmacokinetic parameters were observed. CONCLUSIONS The results of the present study indicate that CYP3A5 and CYP2C19 polymorphisms explain the substantial interindividual variability that occurs in the metabolism of cilostazol.
Prevalence of maxillofacial fracture: A retrospective study

Aim: This study aimed to analyze retrospectively the prevalence, etiology and location, and age and gender distribution of maxillofacial (MF) fractures in the Western part of Maharashtra population. Materials and Methods: Previous records of 1190 patients were evaluated by the observers who had undergone extraoral radiography and occlusal radiography for any diagnostic or treatment purposes between the years 2009 and 2014 were evaluated by the observers. Results: Between the years 2009 and 2014, a total of 2109 MF fractures and associated injuries were collected in 1190 patients and analyzed. Out of the 1190 patients, 697 were male and 493 female. The most commonly affected age group was between 30 and 40 years followed by 20–30 years. The prevalence of road traffic accidents (RTAs) was highest followed by fall, physical assault, sports, and miscellaneous. Conclusion: This study concluded that RTAs were the major cause of fractures. Most fractures occurred in the age group of 31–40 years. Frequency of mandibular fractures was more than midfacial fractures. These findings will be helpful for appropriate health-care policy and management setup in every society.
Control and optimization of turbulent jet mixing

The control of turbulent jet flows has applications in various fields such as combustion, aerodynamic noise, and jet propulsion. Control of mixing can be achieved by manipulation of the large-scale, global instabilities of the flow. In combustors it is important to enhance turbulent mixing of the chemical species in order to achieve high combustion efficiency and to reduce the emission of pollutants. In jet engines, aerodynamic noise can be reduced by controlling flow unsteadiness that produces noise. One aim of enhanced mixing in jet propulsion applications is to decrease the plume temperature and suppress infrared radiation. The mixing rate of a turbulent jet can be significantly altered by applying a suitable excitation at the jet orifice. Since the external forcing interacts with the natural modes of the jet in a nonlinear way, it is not possible to predict which kind of actuation is optimal to increase mixing. Various experiments have been carried out that study the reaction of jets to the nozzle geometry and to external forcing (Lee & Reynolds (1985), Parekh (1987), Parekh (1988)). Different types of actuators such as piezoelectric devices and synthetic jets have been tested (Wiltse (1993), Parekh (1996)). It has been shown that a large spreading of the jet can be achieved with a small mass flow actuation if suitable frequencies are chosen (Parekh (1996)). Numerical simulations of compressible and incompressible jet flows have been carried out that confirm many observations made in experiments with periodically forced jets (Freund (1998), Freund (1999), Danaila (1998), Urbin (1997)). So far it is difficult to carry out a systematic search for the optimal forcing because the simulations are very computationally intensive. Koumoutsakos et al. (1998) showed that evolution strategies are capable of finding suitable actuations for a vortex model and direct numerical simulations of compressible jets. In this paper we describe a systematic search for combined axial and helical forcing of a round jet that maximize mixing. While stochastic search strategies and direct numerical simulation (DNS) of a jet have been combined before (Hilgers (1999), Hilgers (2000)), this work concentrates on the optimization of jets at higher Reynolds numbers using large eddy simulation (LES). Different search strategies are introduced and their performance for the optimization of jet mixing is compared. The strategies are used to search for an actuation that maximizes mixing in jets at Reynolds numbers Re = 6000 and Re = 100000.
Is methadone too dangerous for opiate addiction?

The case for using a safer alternative, buprenorphine, is strong M ethadone is an effective treatment for heroin addiction, and it remains the mainstay of drug treatment for opiate dependence in the United Kingdom.1 The lethal dose of methadone is estimated at 50 mg for an opiate-naive adult.2 Nevertheless, many authorities recommend that methadone doses should be gradually increased to maintenance doses of 80-120 mg1—that is, twice the lethal dose for non-users. The greatly increased risk to users from methadone, particularly black market methadone, thus remains a major concern. Buprenorphine is a partial agonist that has a lower potential for causing respiratory depression than many other opioids, including methadone and heroin.3 It is increasingly used in the United Kingdom to treat opiate dependence, with guidelines for clinical management in primary and secondary care summarised by Ford et al4 and Taikato et al.5 It is time it replaced methadone as the mainstay of drug treatment for opiate dependence. A long running debate continues …
Evidence for the involvement of corrinoids and factor F430 in the reductive dechlorination of 1,2-dichloroethane by Methanosarcina barkeri

Cobalamin and the native and diepimeric forms of factor F430 catalyzed the reductive dechlorination of 1,2-dichloroethane (1,2-DCA) to ethylene or chloroethane (CA) in a buffer with Ti(III) citrate as the electron donor. Ethylene was the major product in the cobalamin-catalyzed transformation, and the ratio of ethylene to CA formed was 25:1. Native F430 and 12,13-di-epi-F430 produced ethylene and CA in ratios of about 2:1 and 1:1, respectively. Cobalamin dechlorinated 1,2-DCA much faster than did factor F430. Dechlorination rates by all three catalysts showed a distinct pH dependence, correlated in a linear manner with the catalyst concentration and doubled with a temperature increase of 10 degrees C. Crude and boiled cell extracts of Methanosarcina barkeri also dechlorinated 1,2-DCA to ethylene and CA with Ti(III) citrate as the reductant. The catalytic components in boiled extracts were heat and oxygen stable and had low molecular masses. Fractionation of boiled extracts by a hydrophobic interaction column revealed that part of the dechlorinating components had a hydrophilic and part had a hydrophobic character. These chemical properties of the dechlorinating components and spectral analysis of boiled extracts indicated that corrinoids or factor F430 was responsible for the dechlorinations. The ratios of 3:1 to 7:1 of ethylene and CA formed by cell extracts suggested that both cofactors were concomitantly active.
H-bridge based multilevel inverter using PWM switching function

This paper proposes an efficient PWM switching function for modified H-bridge based multilevel inverter. The prior H-bridge based multilevel inverter can increase the number of output voltage levels by adding switch components and dc input voltage sources. If it employs seven switches and three dc sources, the number of output voltage levels becomes seven. Although its THD characteristics are improved, it needs output filter to meet general output voltage THD requirement, i.e., 5 % below. To mitigate this problem, we propose an efficient PWM switching method for the prior H-bridge based multilevel inverter. By adding PWM switching schemes to the operation of the prior H-bridge switches, it can synthesize more sinusoidal waveform. By this simple alteration in the switching scheme, it can improve the output voltage THD requirement. To verify the high performance of the proposed switching scheme, we implemented computer-aided simulations and experiment using a prototype.
Black Hole Masses and Host Galaxy Evolution of Radio-Loud Active Galactic Nuclei

We report stellar velocity dispersion measurements for a sample of 28 active galactic nucleus (AGN) host galaxies, including our previous work. Using the mass-dispersion (M•-σ) and the fundamental plane relations, we estimate the black hole mass for a sample of 66 BL Lac objects and investigate the role of black hole mass in the energetics of BL Lac objects. The black hole mass range for different BL Lac spectral types is similar, 107 < M• < 4 × 109. Neither X-ray nor radio luminosity correlates with black hole mass. Low-frequency-peaked BL Lac objects have higher Eddington ratios on average, because of either more beaming or higher intrinsic power. For the black hole mass range 3 × 107 < M• < 109, the radio luminosity of BL Lac objects and flat-spectrum radio quasars spans over 4 orders of magnitude, with BL Lac objects being low-power AGNs. We also investigate the evolution of host galaxies for 39 AGNs out to z ≈ 0.5 with measured stellar velocity dispersions. Comparing the mass-to-light ratio evolution in the observed frame with population synthesis models, we find that single-burst star formation models with zform = 1.4 are consistent with the observations. From our zform = 1.4 model, we estimated the intrinsic mass-to-light ratio evolution in the Cousins R band, Δ log(M/L)/Δz = -0.502 ± 0.08, consistent with that of normal early-type galaxies.
Prevalence and Predictors of Diabetes Mellitus After Lung Transplantation : A Prospective , Longitudinal Study

Between August 2010 and December 2012, 156 patients underwent LTx. DM prevalence after 3, 12, and 24 months was 47%, 44%, and 40%, respectively. A further 20%, 11%, and 7% had impaired glucose tolerance and/or impaired fasting glucose. Incidence of new-onset DMafter transplant (NODAT)was 32%, 30%, and 24%after 3, 12, and 24 months. Nonfasting insulin levels and second phase insulin release fell 3 months after transplant (Tx) but returned to baseline by 2 years. The only risk factors for NODAT were 1and 2-h glucose levels on pre-Tx OGTT (OR 1.73 [95% CI 1.19– 2.50],P = 0.004, and 1.84 [1.22–2.77],P = 0.004, respectively). Survivalwas reduced in patients with DMat study end versus thosewithout (estimatedmean 979 days [95% CI 888–1,071] vs. 1,140 days [1,070–1,210], P = 0.023).
An Empirical Assessment of Information Systems Planning and the Role of Information Systems in Organizations

Abstract:Research in the information systems (IS) field indicates that organizations have different roles for IS in their operations and that various aspects of strategic IS planning will vary depending on the IS role. This study empirically evaluates the differences in planning, organizational support, and performance characteristics of IS planning among organizations with different roles for IS. An operationalization of the “role of IS” is developed on the basis of the notion of a “strategic grid. ” The study also evaluates the relationship between various performance measures and the “fit” between the IS planning process and the role ofIS in the organization. The data for the study were collected from a field survey of 249 firms. The results of the data analyses indicate that there are significant differences in planning, organizational support, and performance characteristics of IS planning among organizations with different roles for IS. The planning and support characteristics generally match the pre.
Allozymic Variation in the Japanese Clawed Salamander, Onychodactylus japonicus (Amphibia: Caudata: Hynobiidae), with Special Reference to the Presence of Two Sympatric Genetic Types

We conducted an electrophoretic survey to examine geographic genetic variation in samples from 17 localities of the Japanese clawed salamander, Onychodactylus japonicus. This species was divided into six genetic groups (N-Tohoku, S-Tohoku, Tsukuba, SW-Honshu, Kinki, and Shikoku) that were largely concordant with clades or subclades recognized in our previous mtDNA study. Although the relationships among these six groups were not clarified, genetic distances between them were not small (mean Nel's D=0. 146–0.471). Among these groups, the geographically isolated Tsukuba group was genetically distinct, possibly as a result of population isolation. In a locality of western Honshu, two groups, SW-Honshu and Shikoku, were found to occur sympatrically. Although several presumable hybrid individuals were found, hybridization between these two groups seemed to occur very rarely. These results indicate that the Shikoku group is specifically distinct from the SW-Honshu group, whose range includes the type locality of O. japonicus.
Neonatal neuroimaging predicts recruitment of contralesional corticospinal tracts following perinatal brain injury

Unilateral perinatal brain injury may result in recruitment of ipsilateral projections originating in the unaffected hemisphere and development of unilateral spastic cerebral palsy (USCP). The aim of this study was to assess the predictive value of neonatal neuroimaging following perinatal brain injury for recruitment of ipsilateral corticospinal tracts.