Miracle-dz/UniFAR-FTUs huggingface dataset:
Control Options for the Public Manager: An Analytic Model for Designing Appropriate Control Strategies

Appropriate control strategy leads to improved public management. Public management control requires a frame of reference that assists practicing managers in recognizing and responding to the various control problems found in the organizational environments of public programs. Typically, these problems include the following: program goals are diverse or ambiguous; agency employees are driven by widely differing intemalized value systems and harbor goals that conflict with goals of other employees as well as with program goals; tasks vary with respect to the available knowledge of the process required to carry out the task; and, in some cases, tasks vary with respect to one's ability to detect when, or even if, the task is completed. The variable combinations of these elements tend to form complex public management problems that require different approaches to management control. This is true in the analysis and fine-tuning of existing control systems for programs in place as well as in the design of prospective control systems for emerging programs. Need for a Framework for the Analysis of Control Problems Management literature is filled with different approaches, techniques, and methods that have been suggested as being useful for maintaining control in organizations. The range of such literature is wide. Political economists, sociologists, social psychologists, organizational theorists, accountants, program evaluators, and organizational economists all address control in organizations. Control issues are approached in the literature at different levels of analysis; they are analyzed from the perspectives of different social assumptions; and separate studies of similar control issues produce multiple, often incompatible
Effect of ethanol on visual-vestibular interactions during vertical linear body acceleration.

BACKGROUND Ethanol led to disturbed dynamic visual acuity (DVA) during vertical linear acceleration (VLA; amplitude, 5 cm; frequency, 1.2 Hz). The aim of this study was to analyze whether suppression of visual-oculomotor or vestibular pathway is responsible for the disturbance of DVA. METHODS Twenty volunteers were investigated before and after ethanol consumption (mean breath alcohol concentration, 0.32 mg/liter). Vertical eye movements and linear head acceleration were recorded. Tested stimuli were vestibular (VLA in the dark), visual (smooth pursuit), and combined (VLA plus fixation on an earth-fixed target) stimulation; visual suppression (VLA plus fixation of a head-fixed target); static visual acuity; and DVA. Parameters of analysis were gain, sensitivity, eye velocity and amplitude, latency between onset of head acceleration and start of eye movement, correct and wrong answers during static visual acuity and DVA testing, feeling of drunkenness (FOD), and breath alcohol concentration. RESULTS Both during isolated visual and during combined visual-vestibular stimulation, alcohol induced a significant latency increase. Furthermore, DVA was disturbed after ethanol consumption. Test subjects with a strong alcohol-induced disturbance of DVA presented during isolated visual stimulation a significantly higher latency change than volunteers with a minor alcohol-induced disturbance of DVA. On the basis of the FOD, two groups were formed (one with a slight and one with a strong FOD). The two groups differed significantly concerning the alcohol-induced latency increase during isolated visual stimulation and the alcohol-induced disturbance of DVA. CONCLUSIONS Ethanol leads to a disturbance of the visual-oculomotor system and, thus, even during combined visual-vestibular stimulation, to a latency increase. This "delay" is responsible for the disturbance of DVA. This alcohol-induced suppression of the visual-oculomotor system and the disturbance of DVA show a significantly positive correlation with the subjective FOD.
Molecular cloning of interleukin 1beta from rainbow trout Oncorhynchus mykiss reveals no evidence of an ice cut site.

The complete coding sequence of rainbow trout IL-1beta has been obtained. The gene contains a short 5' UTR (97 bp), a 780 bp open reading frame and a 466 bp 3' UTR, which includes a polyadenylation signal, 7 ATTTA motifs and an 18 bp poly A tail. The predicted amino acid sequence (260 amino acids) contains 3 potential glycosylation sites, with a predicted molecular weight of 29 kDa, and shows between 49 and 56% amino acid similarity to mammalian IL-1betas and 57% similarity to carp IL-1beta. Greatest homology was apparent within the secondary structure of the gene, with few of the amino acids known to bind to the IL-1 receptor being conserved. No ICE cut site was apparent but multiple alignment with mammalian sequences allowed a putative mature peptide of 166 amino acids to be identified, in which Ala(95)would be the amino terminus. Northern blot analysis showed that whilst no IL-1beta expression was detectable in head kidney leukocytes immediately after isolation, expression could be induced by stimulation with LPS for 4 h in culture. Similarly, with isolated head kidney macrophages expression was significantly increased following stimulation with LPS.
Can Earnings Management be Influenced by Audit Quality

The objective of this study is to examine the prediction that external audit quality is positively associated with earnings management. The primary aim is to help stakeholders predict earning management based on some proxies that are not publicly available in annual reports. This study investigates the informative of audit quality for estimate in earning management (EM) during the period of (2006-2010) of Jordanian Banking Firms listed in Amman Stock Exchange (ASE). Some leading proxies were taken based on audit quality; Audit tenure (AT), Audit fees (AF), and the affiliation with international big auditing firms (INT). Furthermore, other controlling variables used such as; Financial Leverage (FL), (Return on Assets) ROA, (Return on Equity) ROE, (Cash flow/Total assets) CFO, and EM already taken in the analysis. The population of the study comprised of thirteen (13) Jordanian working commercial Banks over a five year period. The study tested the effects of audit quality on earning management using the panel data methodology. The paper finds that; (AT), (AF), and the (INT) have significant relations with earning management. It means, future earning management forecast is predictable based on audit quality leading indicators (AT, AFEE, and INT). In addition to company size, that is, when external auditing is conducted, earning management mitigates. Moreover, no relationship is found between Leverage, ROA, CFO, and Earning management. I conclude, the study examines earning management forecast based on audit quality leading indicators (AT, AFEE, and INT), and company size. These groups; whether commercial banks, or audit quality indicators, have not been well researched in the past literature, especially in the Jordanian Banking Sector.
Human herpesvirus‐6A gQ1 and gQ2 are critical for human CD46 usage

Based on genetic and antigenic differences and on their cell tropism, human herpes virus‐6 (HHV‐6) has been classified into two variants, HHV‐6A and HHV‐6B. Recently, these variants were re‐classified as two different species. The HHV‐6A glycoprotein complex, gH/gL/gQ1/gQ2 binds to its cellular receptor, CD46; however, the corresponding complex in HHV‐6B rarely binds to CD46. To determine which viral molecules in the glycoprotein complex determine HHV‐6A‐CD46 binding, each molecule of the HHV‐6A complex (i.e., gH, gL, gQ1, or gQ2) was replaced with the corresponding HHV‐6B molecule, and the ability of the replaced protein to be incorporated into the complex and the ability of the complex to bind CD46 were examined. It was found that when all four glycoproteins were expressed, they were able to form a tetrameric complex. However, a complex formed by HHV‐6A gH/gL/gQ1/gQ2 complexes replaced with HHV‐6B gQ1 or gQ2 scarcely bind CD46, whereas HHV‐6A complexes in which gH or gL was replaced with the HHV‐6B molecules did bind it. These results indicate that HHV‐6A gQ1 and gQ2 play an important role in CD46 binding.
Management of Inflammatory Bowel Diseases during Pregnancy

Inflammatory bowel diseases (IBD) have a high prevalence in younger patients with child-bearing potential. Usually, pregnancies in women with IBD will develop normally, if the patient is in remission or has minor disease activity at the time of conception. In contrast, the frequency of normal pregnancies is significantly reduced and the frequency of adverse outcomes like preterm birth or miscarriage is increased, when conception occurs in phases with active IBD. Therefore, it is generally recommended to women with IBD to conceive at a time with minor disease activity or in remission. IBD patients who plan to become pregnant or are pregnant should be treated adequately. Currently, it is widely accepted that the treatment of IBD with corticosteroids and 5-ASA derivatives does not increase the risk of malformations or adverse outcomes in pregnant IBD patients. However, a slight increase in the number of pre-term deliveries or reduced birth weight is observed. More recently, it has also been appreciated that azathioprine and 6-MP and presumably also infliximab and other TNF-α blockers can be safely used during pregnancy in IBD, as no significant increase of malformations, miscarriages or adverse pregnancy outcomes is observed. Information on cyclosporine and tacrolimus during pregnancy is scarcer, but it may be continued or started in some situations if clinically needed. Methotrexate is contraindicated, as this drug is known to significantly increase the risk of malformations and spontaneous abortion. Patients, who wish to nurse their babies, may be treated with steroids and 5-ASA derivatives without a significantly increased risk for the newborn.
Identification of critical elements within the JC virus DNA replication origin

The T antigen of JC virus (JCV) does not interact productively with the simian virus 40 (SV40) origin of replication. In contrast, the SV40 T antigen does drive replication from the JCV origin as well as from its own. The basis for this restricted interaction was investigated by analyzing the structure of the JCV replication origin. The replication activities of JCV-SV40 hybrid origin plasmids were tested in cells constitutively producing either the JCV or SV40 T antigen. Results indicated that a region of the JCV origin critical for interaction with the JCV T antigen was positioned to the late side of the central palindrome of the putative core origin. A mutational analysis of this region indicated that the sequence of the A + T-rich tract was primarily responsible for determining the efficiency with which JCV can initiate replication from its origin. The tandemly repeated pentameric sequence AGGGA located proximal to the A + T-rich tract in the JCV enhancer element was found to stimulate JCV, but not SV40, T antigen-mediated replication. The effect on replication of other elements within the JCV enhancer was also dependent on the T antigen employed for initiation. A plasmid containing the replication origin of prototype BK virus was unable to replicate in cells containing JCV T antigen, again indicating the inflexibility of the JCV T antigen in interacting with heterologous origins.
Relationship of Tricuspid Repair at the Time of Left Ventricular Assist Device Implantation and Survival

Purpose Tricuspid regurgitation contributes to right ventricular failure (RVF) and is associated with worse clinical outcomes in patients undergoing left ventricular assist device (LVAD) treatment. However, whether tricuspid valve repair (TVR) at the time of LVAD implantation improves outcomes is not clear. Methods We identified all patients undergoing initial implantation of a long-term continuous-flow LVAD at our institution from March 2006 to August 2011. We assessed the impact of TVR on survival and incidence of RVF using Kaplan-Meier curves and proportional hazards regression adjusted for age, gender, baseline tricuspid regurgitation, RV function, MELD score, albumin, and indication (bridge vs. destination). Results A total of 101 patients were included in the analysis, of which 14 patients underwent TVR concomitant LVAD. All TVR patients had moderate or severe baseline regurgitation. Crude survival was not different between groups. In multivariable models adjusted for confounding factors, TVR showed a significant association with improved survival (HR = 0.1, p = 0.049). Adjusted models showed no difference in RVF. Conclusions In this cohort of patients, TVR at the time of LVAD implantation appears associated with better survival. Additional larger studies are needed to verify the effect of TVR at the time of LVAD implantation, and whether it should be utilized more frequently.
The Modest Impact of the Alcohol Beverage Warning Label on Drinking during Pregnancy among a Sample of African-American Women

Time-series analysis examines the impact of the alcohol warning label on in-pregnancy drinking by 21,127 African-American pregnant women between 1986 and 1995. Controlling for patient characteristics and unemployment rate, the authors find that the label had a significant, modest impact on drinking. The results suggest that more intensive interventions are needed to reduce in-pregnancy drinking.
Failure to Update the Egocentric Representation of the Visual Space Through Labyrinthine Signal

The present study evaluated the capacity to compare retinal and vestibular signals in a heterosensorial matching task. In the first experiment, subjects evaluated the magnitude of passive whole-body rotations in relation to the eccentricity of a visual target briefly presented before rotation. Such a task elicits multimodal sensory stimulations experienced by a subject during normal goal-oriented head movements, i.e., retinal and vestibular stimulations. A good capacity to evaluate vestibular signals in relation with retinal inputs might suggest that the labyrinthine output is part of a cognitive feedback-loop controlling active head movements oriented toward a visual target and/or that the labyrinthine signal might make a major contribution to judging the position of the target in space after goal-directed head movements. Results showed that body rotation magnitudes had to exceed the amplitude of the visual target by about 120 and 89% to be perceived as having a similar magnitude to a 10 degree and an 18 degree visual target, respectively. A second experiment was designed to test whether this major discrepancy originated either from (a) an overestimation of the peripheral visual target locations, (b) an underestimation of the labyrinthine signal, (c) a deficiency in matching sensory signals from different modalities, or (d) any combination of (a), (b), and (c). In the second experiment, the actual perception of retinal and labyrinthine signals, as indicated by verbal responses, was quantified. Results from this experiment showed that most of the large underestimation of the vestibular stimulation found in Experiment I ought to emerge from a poor capacity to integrate heterogeneous sensory signals by the perceptual system rather than from pure misperception of the retinal and/or labyrinthine signals. Overall, results from Experiments I and II argue for a deficiency of the CNS to integrate labyrinthine signals for updating the egocentric representation of the peripheral visual target during passive body (head) rotations.
Lumbar Puncture and Brain Herniation in Acute Bacterial Meningitis: A Review

There has been controversy regarding the risk of cerebral herniation caused by a lumbar puncture (LP) in acute bacterial meningitis (ABM). This review discusses in detail the issues involved in this controversy. Cerebral herniation occurs in about 5% of patients with ABM, accounting for about 30% of the mortality. In many reports, LP is temporally strongly associated with this event of herniation and is most likely causative based on pathophysiologic arguments. Although a computed tomography (CT) scan of the head is useful to find contraindications to an LP, a normal CT scan in ABM does not mean that an LP is safe. Clinical signs of “impending” herniation are the best predictors of when to delay an LP because of the risk of precipitating herniation, even with a normal CT scan. Some of these clinical signs to be considered are deteriorating level of consciousness (particularly to a Glasgow Coma Scale of ≤ 11), brainstem signs (including pupillary changes, posturing, or irregular respirations), and a very recent seizure. The risk of not doing an LP when it is contraindicated because of concern of the risk of herniation is extremely small. In those considered high risk for herniation, interventions to control intracranial pressure, such as attention to airway, breathing, and circulation, with a mannitol infusion and antibiotics started, should be the priorities, followed by an urgent CT scan and not an LP.
Adaptation and Response of Bifidobacterium animalis subsp. lactis to Bile: a Proteomic and Physiological Approach

ABSTRACT Bile salts are natural detergents that facilitate the digestion and absorption of the hydrophobic components of the diet. However, their amphiphilic nature makes them very inhibitory for bacteria and strongly influences bacterial survival in the gastrointestinal tract. Adaptation to and tolerance of bile stress is therefore crucial for the persistence of bacteria in the human colonic niche. Bifidobacterium animalis subsp. lactis, a probiotic bacterium with documented health benefits, is applied largely in fermented dairy products. In this study, the effect of bile salts on proteomes of B. animalis subsp. lactis IPLA 4549 and its bile-resistant derivative B. animalis subsp. lactis 4549dOx was analyzed, leading to the identification of proteins which may represent the targets of bile salt response and adaptation in B. animalis subsp. lactis. The comparison of the wild-type and the bile-resistant strain responses allowed us to hypothesize about the resistance mechanisms acquired by the derivative resistant strain and about the bile salt response in B. animalis subsp. lactis. In addition, significant differences in the levels of metabolic end products of the bifid shunt and in the redox status of the cells were also detected, which correlate with some differences observed between the proteomes. These results indicate that adaptation and response to bile in B. animalis subsp. lactis involve several physiological mechanisms that are jointly dedicated to reduce the deleterious impact of bile on the cell's physiology.
The Confidentiality of Medical Information in the Workplace

Ethical dilemmas involving confidentiality issues are frequently encountered in occupational medicine. The occupational physician faces a unique challenge because in many circumstances, a physicianpatient relationship, in the ordinary or legal sense, may not exist. The occupational physician ofien faces a conflicting interest between the employee's desire for privacy and the employer's legitimate need to know. The occupational physician must carefully balance these interests for the benefit of society and the parties involved. Occupational physicians also work in a wide variety of practice situations, and the ethical and legal duty of confidentiality may vary substantially with these roles. This article provides an overview of the ethical and legal requirements of confidentiality in the workplace. The constitutional, statutory, and common law framework governing the treatment of employee medical information, as well as defenses to liability, are discussed. Recent legislative changes such as the Americans with Disabilities Act, and new challenges such as the proper handling of HIV information, present unique confidentiality problems.
Naloxone Inhibits A6 Cell Na+/H+ Exchange by Activating Protein Kinase C via the Mobilization of Intracellular Calcium

The opioid receptor antagonist, naloxone, has been shown to have beneficial effects in the kidney and to be implicated in renal salt and water balance. In the present study the signal transduction pathways utilized by naloxone were studied in an epithelial cell line model of the cortical collecting duct, A6 cells. We found that naloxone has a dual effect depending on the concentration used: at a low concentration (10–6M) it antagonized the β-endorphin-dependent increase in cytoplasmic calcium [Ca2+]i, while at higher concentrations (>10–5M) it increased [Ca2+]i and intracellular inositol phosphate levels. While naloxone-induced increases in [Ca2+]i occurred in the absence of external calcium, it was significantly stimulated by increasing the external calcium concentration, suggesting that naloxone increases [Ca2+]i via both calcium release and calcium influx. In polarized A6 cell monolayers naloxone inhibited the activity of the Na+/H+ exchanger (NHE) only when added to the basolateral cell surface. This inhibition of the NHE was prevented by pretreatment of the cells with either the intracellular calcium chelator, BAPTA or with the protein kinase C inhibitor, calphostin C. These findings demonstrate that naloxone induces a rapid increase in intracellular calcium which inhibits the NHE via the calcium-dependent protein kinase C regulatory pathway.
Relationship between competitive strategy and construction organisation performance

Purpose The purpose of this paper is to examine the possible moderating role of organisational characteristics (organisational structure, management style and decision-making style) in the relationship between strategy and organisational performance among large construction organisations in South Africa. Design/methodology/approach The study adopted a quantitative research approach using a questionnaire survey to obtain data from 72 large construction organisations in South Africa. Using hierarchical multiple regression, the paper examines the relationship between the constructs discussed in the study. Findings The internal characteristics of the organisation form the vital basis for achieving optimal performance. The results obtained from the analysis revealed that decision-making style directly influences the measure of organisational effectiveness, while it could also be inferred that organisational characteristics partly moderate the relationship between competitive strategy and organisational performance. The findings indicate that internal characteristics is one of the means through which organisational strategic factors and contextual aspects are organised to achieve greater organisational performance levels. Originality/value The findings have theoretical implications for strategic management literature in construction as it extends the scope of research on strategic management from assessing a set of individual management practices to evaluating a complex mechanism that connects internal characteristics and competitive advantage. It is believed that this study will contribute positively to the role of organisational characteristics in the competitive strategy-performance relationships in large construction organisations in South Africa and to the ongoing discussion on emerging strategic management issues in construction.