Miracle-dz/UniFAR-FTUs huggingface dataset:
Managing adipsic diabetes insipidus following anterior communicating artery aneurysm in a subtropical climate

Diabetes insipidus without perception of thirst, as may follow an anterior communicating artery aneurysm, requires prescription of fluid intake as well as desmopressin. The management goal of maintaining a normal serum sodium is rendered more challenging in a humid subtropical environment, where insensible losses are higher.
Chronically Low-Performing Schools and Turnaround: Evidence from Three States.

This paper presents a new method of empirically identifying CLP schools and binning them into performance categories based on their trajectories. The method as it is applied here will be useful to state or local education agencies charged with similar tasks of identifying their lowest performers, and monitoring signs of improvement. Our findings show that low-performing schools turned around their performance more frequently than one might have presumed based on prior literature. In Florida, we identified approximately 15% of chronically low-performing elementary and 14% of chronically low-performing middle schools as turnarounds. Similar rates were observed in North Carolina—13% and 16%, respectively; and even higher in Texas—29% and 31%, respectively.
Balanced boundary layers used in hurricane models

We examine the formulation and accuracy of various approximations made in representing the boundary layer in simple axisymmetric hurricane models, especially those that assume strict gradient wind balance in the radial direction. Approximate solutions for a steady axisymmetric slab boundary‐layer model are compared with a full model solution. It is shown that the approximate solutions are generally poor in the inner core region of the vortex, where the radial advection term in the radial momentum equation is important and cannot be neglected. These results affirm some prior work and have implications for a range of theoretical studies of hurricane dynamics, including theories of potential intensity, that employ balanced boundary‐layer formulations. Copyright © 2008 Royal Meteorological Society
PENGARUH HARGA,KUALITAS PRODUK DAN KUALITAS PELAYANAN TERHADAP KEPUASAN PELANGGAN RESTORAN O-MAMAMIA STEAK AND ICE CREAM CABANG JATI SEMARANG

O-Mamamia restaurant Steak n Ice Cream Semarang is a steak restaurant providing ice cream at the same time, which has ten branches one branch is O-Mamamia Restaurant Steak n Ice Cream Jati Semarang. In an effort to maintain relationships with customers, service quality is the key to retaining customers and providing high value through customer value. Customers will compare the quality of services provided at a price that is charged for the steak provided. Currently there is a restaurant that provides a lot of steak menu, causing intense competition. Intense competition will directly affect the number of customers coming as it did on the O-Mamamia Restaurant Steak n Ice Cream Jati Semarang which decreased the number of customers each year. This study aimed to determine the effect of pricing, product quality and service quality on customer satisfaction O-Mamamia Steak n Ice Cream Teak Semarang. The population in this study is the customer O-Mamamia Restaurant Steak n Ice Cream Teak Semarang. The research sample of 100 respondents was taken and the sampling technique used is purposive sampling. Measurement scales using Likert scale. In the analysis of the data using simple linear regression and multiple regression test with the help of the program SPSS 18.00. Based on the survey results revealed the price variable has an influence on the customer satisfaction variables, where the t value (3.456)> t table (1.29025). That is, for a positive and significant impact on customer satisfaction. Value of the coefficient of determination of 0.109 or 10.9%. This means that 10.9% customer satisfaction variables can be explained by the variable price. Variable product quality has an influence on the customer satisfaction variables, where the t value (4.905)> t table (1.29025). That is, the product quality has positive and significant impact on customer satisfaction. Value of the coefficient of determination of 0.197 or 19.7%. Variable Quality of Service has a variable effect on customer satisfaction, which amounted to 8.451 t count> t table of 1.29025 means that service quality has positive and significant impact on customer satisfaction. Value of the coefficient of determination of 0.422 or 42.2% Suggestions put forward for O-Mamamia Restaurant Steak n Ice Cream Teak Semarang is need for adjustment between the tariff charged to consumers with the quality of services provided, maintaining the delicious taste, customer service should be further enhanced.
OxyContin Misuse on a Reservation: Qualitative Reports by American Indians in Talking Circles

Few studies have addressed OxyContin use among American Indians (AIs) on reservations. Eight focus groups were conducted as “talking circles” (2006 and ) with 49 AI adults and youth. An emergent design was utilized in which the initial two circles were planned, but the subsequent six circles evolved from tribal members’ input. Participants reported an increase in OxyContin use; negative effects on individuals, families, and the tribe; a lack of treatment options; and a growing problem on other reservations. Results indicate the need to further research prevalence and patterns of use to design interventions to curtail OxyContin abuse on reservations.
Deletions in the N-terminal coding region of the v-sis gene: determination of the minimal transforming region

The gene product of the v-sis gene is closely related to the B chain of platelet-derived growth factor (PDGF). However, v-sis also encodes additional amino acids at its N and C termini, which are not represented in the sequence data of PDGF. We have constructed a series of N-terminal deletion mutants in the v-sis gene to define the minimum region required for transformation. These mutants were assayed for biological activity by using retroviral expression vectors which donate a signal sequence, required for translocation across the rough endoplasmic reticulum, to the mutant gene product. The minimal transforming region of the v-sis gene product defined by this analysis has 15 residues missing at the N terminus when compared with the PDGF-B chain. There are only two residues separating the closest transforming and nontransforming gene products. Mutant gene products lacking both the basic dipeptide processing site and the N-linked glycosylation site were found to be biologically active, indicating the dispensability of those processing steps. These results delimit the minimal transforming region of the v-sis gene product to residues 127 through 214, a total of 21 residues smaller than the PDGF-B chain.
Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)‐related and HPV‐unrelated sites in a multicultural population

There is a growing recognition of the involvement of human papilloma virus infection in the etiology of head and neck cancers at some sites, mainly the base of the tongue, tonsils, and other oropharynx (hereafter termed oropharyngeal cancer). Other oral sites (hereafter termed oral cavity cancer [OCC]) show a stronger association with tobacco and alcohol. Little is known about the ethnic variation in incidence for these cancers. This study determined incidence rates of OCC and oropharyngeal cancer among South Asian, Chinese, and the general population in British Columbia, Canada.
Effects of foreign presence and affiliate control on the productivity of domestic companies in a transition economy: the case of Polish manufacturing 1993-2002

The aim of this paper is to study the significance of Foreign Direct Investments and their spillover effects in a transition country such as that of Poland. A unique cross-industry dataset on foreign companies, domestic private and domestic public companies has been analysed. Four different measures (foreign equity, sales, investments and labour) of foreign presence as a share of the whole industry have been used. The results show that the level of productivity of domestic private companies has increased steadily since 1994. A high share of foreign sales and foreign equity in the industry has a negative impact on the productivity of private companies, thus implying a “crowding out” effect. No evidence has been found for association between productivity in domestic companies and foreign control over MNE affiliates which may indicate tacit knowledge spillovers. Control variables such as one year lagged labour compensation and scale in domestic private and public companies are positively associated with their productivities.
The advances in cardiac PET also interact powerfully with documentation that vigorous pharmacologic and lifestyle management stabilize plaque, partially reverse coronary artery disease (CAD), and decrease cardiac events by 90% at long-term follow-up. While not widely recognized, cardiac PET-includin

Clinical applications of cardiac positron emission tomography (PET) have made dramatic advances over the past three years, particularly in myocardial perfusion imaging. These advances include cardiac-specific PET technology, specialized software, and profound biological insights into myocardial perfusion far beyond the traditional binary interpretation of perfusion images as normal or abnormal requiring arteriorgaphic confirmation.
Sphingolipids activate membrane fusion of Semliki Forest virus in a stereospecific manner.

The alphavirus Semliki Forest virus (SFV) enters cells through receptor-mediated endocytosis. Subsequently, triggered by the acid pH in endosomes, the viral envelope fuses with the endosomal membrane. Membrane fusion of SFV has been shown previously to be dependent on the presence of cholesterol in the target membrane. Recently, we have demonstrated that fusion of SFV also requires sphingolipids [Nieva, J. L. , Bron, R. , Corver, J., & Wilschut, J. (1994) EMBO J. 13, 2797-2804]. In the present paper, we show that the activation of low-pH-dependent fusion of SFV by sphingolipids is a stereospecific process. Pyrene-labeled SFV fused rapidly and extensively with liposomes consisting of a mixture of phosphatidylcholine, phosphatidylethanolamine, and cholesterol, supplemented with low concentrations of D-erythro-ceramide, representing the naturally occurring sphingolipid stereoisomer. Fusion was assessed by a decrease in the pyrene excimer fluorescence. L-erythro-, D-threo-, and L-threo-ceramide did not support fusion of the virus. Similar results were obtained with the corresponding sphingomyelin stereoisomers. The stereospecificity of SFV fusion activation was confirmed by using an assay based on degradation of the viral capsid protein by trypsin encapsulated in the target liposomes. Fusion mediated by D-erythro-ceramide was not affected by the additional presence in the target liposomes of ceramide stereoisomers incapable of fusion activation. Binding of the virus to the liposomes, as assessed by flotation on sucrose density gradients, was not dependent on the presence of fusion-competent or fusion-incompetent sphingolipids in the liposomes. The results of this study support the notion that a stereospecific interaction of the viral fusion protein with D-erythro sphingolipids in the target membrane represents an essential step in the activation of the fusion capacity of SFV.
Enhancement of high-Ns electron mobility in sub-nm EOT Ge n-MOSFETs

This paper presents the peak mobility of 787 cm<sup>2</sup>/Vs and high-N<sub>s</sub> mobility (@N<sub>s</sub>=10<sup>13</sup> cm<sup>-2</sup>) of 429 cm<sup>2</sup>/Vs in Ge n-MOSFETs with sub-nm EOT, which are the highest ones to date among scaled Si and Ge MOSFETs. This can be achieved by intermixing of Y atoms with GeO<sub>2</sub>, which offers the strong hygroscopic tolerance and thermal process stability as well as interface improvement.
The 3′-Untranslated Region of Murine Cyclooxygenase-2 Contains Multiple Regulatory Elements That Alter Message Stability and Translational Efficiency*

Renal mesangial cells regulate their expression of the pro-inflammatory gene cyclooxygenase-2 (COX-2) through mechanisms involving gene transcription and post-transcriptional events. Post-transcriptional regulation of COX-2 is dependent, in part, on sequences within the 3′-untranslated region (3′-UTR) of the COX-2 mRNA. Insertion of the entire 3′-UTR of COX-2 into the 3′-UTR of luciferase resulted in a 70% decrease in luciferase enzymatic activity. Measurement of steady-state reporter gene mRNA levels suggested that the loss of activity was due to decreased translational efficiency. Deletion analysis identified the first 60 nucleotides of the 3′-UTR of COX-2 as a major translational control element. This region of the 3′-UTR of COX-2 is highly conserved across species; is AU-rich; and contains multiple repeats of the regulatory sequence AUUUA, reported to confer post-transcriptional control. In addition, we identified regions of the 3′-UTR of COX-2 outside of the first 60 nucleotides that altered message stability. Some of these regions contained AUUUA consensus sequences, whereas others did not, and represent novel control elements. These results suggest that expression of COX-2 in mesangial cells depends on the complex integration of multiple signals derived from the 3′-UTR of the message.
Takeover Defenses, Innovation, and Value-Creation: Evidence from Acquisition Decisions

The desirability of anti-takeover provisions (ATPs) is a contentious issue. ATPs might enable managerial empire building by insulating managers from disciplinary takeovers. However, some companies, such as ‘hard-to-value’ (HTV) companies, might trade at a discount due to valuation difficulties, thereby exposing HTV companies to opportunistic takeovers, and creating agency conflicts of managerial risk-aversion. ATPs might ameliorate such managerial risk aversion by inhibiting opportunistic takeovers. This paper analyzes acquisitions made by HTV firms, focusing on whether the acquirer (not the target) is entrenched in order to examine the impact of entrenchment managerial decision-making. The results show that HTV firms that are entrenched make acquisitions that generate more shareholder wealth and are more likely to increase corporate innovation, suggesting that ATPs can be beneficial in some firms.
The Verification of an Industrial Payment Protocol

The Secure Electronic Transaction (SET) protocol has been proposed by a consortium of credit card companies and software corporations to secure e-commerce transactions. When the customer makes a purchase, the SET dual signature guarantees authenticity while keeping the customer’s account details secret from the merchant and his choice of goods secret from the bank. This paper reports the rst verication results for the complete purchase phase of SET. Using Isabelle and the inductive method, we showed that the credit card details do remain conden tial and customer, merchant and bank can conrm most details of a transaction even when some of those details are kept from them. The complex protocol construction makes proofs more dicult but still feasible. Though enough goals can be proved to give condence in SET, a lack of explicitness in the dual signature makes some agreement properties fail: it is impossible to prove that the customer meant to sent his credit card details to the payment gateway that receives them.
Effect of anticoagulation upon nephron obstruction in experimental acute ischaemic renal failure. A morphological study

Ischaemic‐reperfusion injury as a model of acute renal failure (ARF) results in increased macromolecular permeability, tubular obstruction, and renal oedema. To investigate the role for coagulation in this model, anticoagulated and saline‐pretreated rats were subjected to 60 min unilateral renal artery occlusion (RAO). After 15 min of reflow, specimens were collected for electron and light microscopic examination. Morphometry was employed to study podocyte changes and Bowman's space dilatation as measures of increased permeability and tubular obstruction, respectively. After 15 min of reflow, Bowman's space increased significantly and the podocytes were markedly widened and flattened. Rats pretreated with heparin or warfarin showed less widening of Bowman's space than saline‐treated rats, whereas no significant difference was seen regarding the podocyte changes. In saline‐treated rats, fibrin‐positive material was seen in the tubules but not in the urine sediments collected after 90 min of reflow, either due to fibrinolysis or poor urinary elimination. The results suggest that anticoagulation does not preclude the glomerular sieving of macromolecules, but seems to reduce tubular obstruction, probably by preventing conversion of filtered fibrinogen into fibrin.
Essential Role of Pten in Body Size Determination and Pancreatic β-Cell Homeostasis In Vivo

ABSTRACT PTEN (phosphatase with tensin homology) is a potent negative regulator of phosphoinositide 3-kinase (PI3K)/Akt signaling, an evolutionarily conserved pathway that signals downstream of growth factors, including insulin and insulin-like growth factor 1. In lower organisms, this pathway participates in fuel metabolism and body size regulation and insulin-like proteins are produced primarily by neuronal structures, whereas in mammals, the major source of insulin is the pancreatic β cells. Recently, rodent insulin transcription was also shown in the brain, particularly the hypothalamus. The specific regulatory elements of the PI3K pathway in these insulin-expressing tissues that contribute to growth and metabolism in higher organisms are unknown. Here, we report PTEN as a critical determinant of body size and glucose metabolism when targeting is driven by the rat insulin promoter in mice. The partial deletion of PTEN in the hypothalamus resulted in significant whole-body growth restriction and increased insulin sensitivity. Efficient PTEN deletion in β cells led to increased islet mass without compromise of β-cell function. Parallel enhancement in PI3K signaling was found in PTEN-deficient hypothalamus and β cells. Together, we have shown that PTEN in insulin-transcribing cells may play an integrative role in regulating growth and metabolism in vivo.
In vitro study to simulate the intracardiac magnetohydrodynamic effect

Blood flow causes induced voltages via the magnetohydrodynamic (MHD) effect distorting electrograms (EGMs) made during magnetic resonance imaging. To investigate the MHD effect in this context MHD voltages occurring inside the human heart were simulated in an in vitro model system inside a 1.5 T MR system.
Central Mucoepidermoid Carcinoma of Mandible: A Case Report

Central mucoepidermoid carcinoma (CMC) is an uncommon tumor, comprising 2-3 % of all mucoepidermoid carcinomas reported. The majority of cases occurring in the 4th and 5th decades of life and they are histologically low-grade malignant neoplasm usually affecting the mandible. The case presented is a 41 year old woman with central mucoepidermoid carcinoma at the left posterior of the mandible as a swelling with purulent discharge since last year. Radiographic examination showed a radiolucent lesion with well-defined borders in distal area of ┌8.
Estimation of conduction velocity vector fields from epicardial mapping data

An automated method to estimate vector fields of propagation velocity from observed epicardial extracellular potentials is introduced. The method relies on fitting polynomial surfaces T(x,y) to the space-time (x,y,t) coordinates of activity, Both speed and direction of propagation are computed from the gradient of the local polynomial surface. The components of velocity, which are total derivatives, are expressed in terms of the partial derivatives which comprise the gradient of T. The method was validated on two-dimensional (2-D) simulations of propagation and then applied to cardiac mapping data. Conduction velocity was estimated at multiple epicardial locations during sinus rhythm, pacing, and ventricular fibrillation (VF) in pigs. Data were obtained via a 528-channel mapping system from 23/spl times/22 and 24/spl times/21 arrays of unipolar electrodes sutured to the right ventricular epicardium. Velocity estimates are displayed as vector fields and are used to characterize propagation qualitatively and quantitatively during both simple and complex rhythms.
Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

FAK inhibitor treatment is effective against Merlin-negative mesothelioma tumors and preferentially targets cancer stem cells. Therapeutic Magic Without Merlin Mesothelioma is an aggressive cancer of the pleura (lung lining), which is very difficult to treat and often recurs after therapy. Now, Shapiro and coauthors have discovered that mesotheliomas and other tumors that are low in a tumor suppressor called Merlin are particularly sensitive to treatment with a new drug called VS-4718, which blocks the activity of the enzyme focal adhesion kinase. Moreover, in preclinical testing, VS-4718 was particularly effective at killing cancer stem cells, which are the hardest to eradicate with conventional chemotherapy and can give rise to recurrent tumors. These results suggest that VS-4718 or a similar drug may make a valuable addition to the standard treatment regimen for mesothelioma and may reduce the risk of relapse in this cancer. The goal of targeted therapy is to match a selective drug with a genetic lesion that predicts for drug sensitivity. In a diverse panel of cancer cell lines, we found that the cells most sensitive to focal adhesion kinase (FAK) inhibition lack expression of the neurofibromatosis type 2 (NF2) tumor suppressor gene product, Merlin. Merlin expression is often lost in malignant pleural mesothelioma (MPM), an asbestos-induced aggressive cancer with limited treatment options. Our data demonstrate that low Merlin expression predicts for increased sensitivity of MPM cells to a FAK inhibitor, VS-4718, in vitro and in tumor xenograft models. Disruption of MPM cell-cell or cell–extracellular matrix (ECM) contacts with blocking antibodies suggests that weak cell-cell adhesions in Merlin-negative MPM cells underlie their greater dependence on cell-ECM–induced FAK signaling. This provides one explanation of why Merlin-negative cells are vulnerable to FAK inhibitor treatment. Furthermore, we validated aldehyde dehydrogenase as a marker of cancer stem cells (CSCs) in MPM, a cell population thought to mediate tumor relapse after chemotherapy. Whereas pemetrexed and cisplatin, standard-of-care agents for MPM, enrich for CSCs, FAK inhibitor treatment preferentially eliminates these cells. These preclinical results provide the rationale for a clinical trial in MPM patients using a FAK inhibitor as a single agent after first-line chemotherapy. With this design, the FAK inhibitor could potentially induce a more durable clinical response through reduction of CSCs along with a strong antitumor effect. Furthermore, our data suggest that patients with Merlin-negative tumors may especially benefit from FAK inhibitor treatment.
Ebola and marburg viruses: I. Some ultrastructural differences between strains when grown in vero cells

A strain of Marburg virus and two strains of Ebola virus grown in Vero cells were compared by electron microscopy. The outer coat of the Marburg virion appeared to be more resistant to erosion by negative staining techniques than that of the Ebola strains. Marburg virus commonly produced “torus” forms and short filaments: the Zaire strain of Ebola produced extensive branched forms and very long filaments; the Sudan strain of Ebola produced shorter, less branched structures but very many aberrant forms. The mechanism for the production of these aberrant forms is described.