Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Throughput Screening Identifies miR-451 as a Pleiotropic Modulator That Suppresses Gastric Cancer Metastasis

MicroRNAs (miRNAs) are globally dysregulated in human carcinomas. However, the specific miRNAs that mediate gastric cancer metastasis have not been identified. We identified 100 miRNAs that are dysregulated in gastric cancer and used a self-assembled cell microarray method to systematically evaluate their capacity to regulate cell migration. MiR-451, which is down-regulated in human gastric cancer samples, potently modulated multiple metastatic phenotypes including cell migration, invasion, proliferation, and epithelial-mesenchymal transition. These effects were achieved via down-regulation of the miR-451 target gene, ERK2. These findings provide new insight into the physiological effects of and potential therapeutic uses for miRNAs in gastric cancer.
Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender.

Protein Z was recently shown to act as an essential cofactor for protein Z-dependent protease inhibitor, a potent downregulator of coagulation Factor Xa. Thus, deficiency of protein Z is hypothesized to lead to a prothrombotic state, but two publications reported opposing results for the relationship of protein Z levels with ischemic stroke in young European subjects (mean age 33-40 years). We performed a study of stroke in a different ethnic population of greater mean age (57 years) to further clarify this issue. An ELISA was developed to measure protein Z antigen in 154 patients with ischemic stroke and in 206 controls in a largely Hispanic population. Low plasma protein Z values were significantly associated with ischemic stroke except in diabetic subjects and females. The mean protein Z value was significantly lower in stroke cases than in controls for nondiabetic subjects [1.78 +/- 0.77 (S.D.) versus 2.28 +/- 0.88 microg/ml, P < 0.0001] and for males (1.90 +/- 0.90 versus 2.42 +/- 0.99 microg/ml, P = 0.0004). Stroke risk was higher in subjects with protein Z levels at or below the fifteenth percentile of controls (</=1.46 microg/ml). The odds ratios were: 2.6 for all subjects (95% C.I. = 1.5-4.3); 3.8 for nondiabetic subjects (95% C.I. = 2.2-6.8); and 3.6 for males (95% C.I. = 2.0-6.4). This study also revealed high protein Z levels associated with high triglyceride levels in controls (P = 0.015). Protein Z is suggested to be a physiologic downregulator of blood coagulation and low protein Z levels are associated with increased risk of ischemic stroke, particularly in males and in the absence of diabetes.
CXCL 12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans

The chemokine CXCL12 (also known as stromal cell-derived factor, SDF-1) is constitutively expressed by stromal resident cells and is involved in the homeostatic and inflammatory traffic of leukocytes. Binding of CXCL12 to glycosaminoglycans on endothelial cells (ECs) is supposed to be relevant to the regulation of leukocyte diapedesis and neoangiogenesis during inflammatory responses. To improve our understanding of the relevance of this process to rheumatoid arthritis (RA), we have studied the mechanisms of presentation of exogenous CXCL12 by cultured RA ECs. RA synovial tissues had higher levels of CXCL12 on the endothelium than osteoarthritis (OA) tissues; in both, CXCL12 colocalized to heparan sulfate proteoglycans (HSPGs) and high endothelial venules. In cultured RA ECs, exogenous CXCL12α was able to bind in a CXCR4independent manner to surface HSPGs. Desulfation of RA EC HSPGs by pretreatment with sodium chlorate, or by replacing in a synthetic CXCL12α the residues Lys24 and Lys27 by Ser (CXCL12α-K2427S), decreased or abrogated the ability of the chemokine to bind to RA ECs. Ex vivo, synovial ECs from patients with either OA or RA displayed a higher CXCL12binding capacity than human umbilical vein ECs (HUVECs), and in HUVECs the binding of CXCL12 was increased on exposure to tumor necrosis factor-α or lymphotoxin-α1β2. Our findings indicate that CXCL12 binds to HSPGs on ECs of RA synovium. The phenomenon relates to the interaction of HSPGs with a CXCL12 domain with net positive surface charge located in the first β strand, which encompasses a canonical BXBB HSPGbinding motif. Furthermore, we show that the attachment of CXCL12 to HSPGs is upregulated by inflammatory cytokines. Both the upregulation of a constitutive chemokine during chronic inflammation and the HSPG-dependent immobilization of CXCL12 in EC surfaces are potential sites for therapeutic intervention. Introduction Chemokines are a large family of soluble proteins involved in leukocyte activation and traffic during inflammatory responses. Chemokines signal through G-protein-coupled receptors [1]. In vivo, chemokine-dependent directional migration of leukocytes is supposed to require the immobilization of chemokines either to the extracellular matrix or to cell surfaces. Chemokines induce cell-matrix or cell-cell adhesion through the activation of integrins, and studies in vivo demonstrate that the presence of chemokines immobilized on the luminal side of endothelium is a critical step for firm adhesion and transendothelial migration of rolling leukocytes [2-6]. This phenomenon can be reproduced in vitro in cultured endothelial cells (ECs) and depends on the addition of exogenous chemokines and the presence of fluid shear-induced mechanical stress on leukocytes [5,6]. Endothelial cells secrete a limited number of chemokines, suggesting that many of the homeostatic or inflammatory chemokines presented at the EC surface come from other cell sources by transcytosis and docking of chemokines on the EC luminal surface [7-9].
The politics of climate change in the UK

Between 2006 and 2010 climate change rose rapidly up the UK political agenda and the Labour Government, with cross‐party support, introduced major changes in domestic climate and energy policy, including the landmark Climate Change Act 2008, which represented an important step toward the UK becoming a low carbon economy. Cross‐party consensus was initially sustained by the Conservative‐Liberal Democrat Coalition, before growing criticism from the political right began to turn climate change into an increasingly partisan issue, thereby weakening the commitment of David Cameron to climate leadership. The article examines the transition of climate change from low politics to high politics, assessing the role of public opinion, the media, business, environmental groups, and party competition in overcoming the obstacles to progressive climate change and energy policy. The roles of party politics and of individual political leadership are identified as critical factors in raising the profile of climate change and delivering radical policy change. The significance of the growing partisan divisions over climate change is assessed.
Innovate or liquidate ‐ are all organisations convinced? A two‐phased study into the innovation process

Striving to survive in the ever changing world, the ability to innovate has become increasingly crucial. But are all organisations convinced? Based on data collected from a recent survey and a telephone interview, this article examines the general understanding of issues concerning innovation among managers and their ability to translate this understanding into practice. The study reveals that while most organisations have realised the importance of innovation and are prepared to mobilise their managers to be involved in innovation projects, many of them have not yet been able to create an innovation culture and devise suitable policies to encourage innovation positively within the wider context of their organisations. It is also discovered that there is a surprisingly low level of understanding of the most commonly known innovation techniques, yet most people dismiss the value of creativity training programmes conducted in their organisations, raising serious concerns over the effectiveness of these programmes.
Acute changes in intermediary metabolism in cerebellum and contralateral hemisphere following middle cerebral artery occlusion in rat

Focal ischemia leads to functional deafferentation of regions connected to the ischemic area via fiber tracts. Using i.v. administration of 13C‐labeled glucose and acetate combined with ex vivo13C MR spectroscopy and HPLC of brain extracts we identify the effect of middle cerebral artery occlusion (MCAO) on neurotransmitter synthesis and turnover, and on neuro‐astrocytic interactions in the non‐ischemic cerebellum and in contralesional lateral caudoputamen plus lower parietal cortex (LPC), and upper frontoparietal cortex (UFPCx) in the rat after 30, 60, 120 and 240 min of ischemia. In all regions, there was a significant persisting loss of glutamate, and in LCP and UFPCx also of glutamine, but only in LCP was GABA reduced at all times. Metabolism and blood flow were uncoupled in all regions. In cerebellum, glucose metabolism as well as utilization of intermediates derived from astrocytic tricarboxylic acid cycle activity were significantly decreased at all times in both glutamatergic and GABAergic neurons. In LCP and UFPCx, there were normal or increased enrichment in glutamate and GABA from glucose. Glutamate derived from astrocytic acetate metabolism was increased, but GABA synthesis from acetate was initially impaired. The results showed that both the type of afferent connection, i.e., glutamatergic and/or GABAergic, and local cytoarchitecture, determined the effect MCAO had on metabolic activity in the non‐ischemic regions. In conclusion, it was primarily excitatory input into non‐ischemic regions that was affected by MCAO, perhaps enabling resetting of the excitatory/inhibitory balance, aiding reshaping of the receptive fields and thus facilitating recovery.
Evaluation of Random Amplified Polymorphic DNA Typing of Pseudomonas aeruginosa

ABSTRACT A method for distinguishing among Pseudomonas aeruginosa strains using random amplified polymorphic DNA (RAPD) typing was evaluated for reproducibility and discriminatory power. A total of 200 isolates, blinded in triplicate, were evaluated by RAPD. All 600 samples were typeable; 197 of 200 isolates gave identical results on all three occasions, and 131 distinct RAPD types were identified.
The European Social Model (ESM) and cultural diversity in Europe

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Strategic Incentives in Teams: Implications of Returns to Scale

This article demonstrates the critical relationship between the characteristics of the production function and the strategic incentives in a team. Equilibrium effort increases in team size when substitutability is low relative to returns to scale. Effort levels are actually strategic complements when returns to scale exceed the substitutability of members' effort. Moreover, even with equal shares the well-known equation 1/n problem is determined by returns to scale and becomes worse as returns increase. While a target scheme can support the optimal output level as an equilibrium, it does not completely deter free riding. A team member will accommodate shirking by increasing their own effort within a remarkably large “accommodation zone” where the additional effort cost is less than the bonus. This accommodation of shirking by others exists for different returns to scale and even for very low levels of substitutability.
The relationship between atrial electromechanical delay and P-wave dispersion with the presence and severity of metabolic syndrome.

OBJECTIVES In this study, we aimed to investigate the association between the presence and severity of metabolic syndrome (MetS) with intra- and inter-atrial electromechanical delay (AEMD) and P-wave dispersion (PWD). STUDY DESIGN A total of 144 patients (72 MetS patients and 72 age- and sex-matched control subjects) were included in the study. Patients with MetS were classified into three groups based on the number of MetS criteria as follows: Group 1 (patients with three MetS criteria), Group 2 (patients with four MetS criteria) and Group 3 (patients with five MetS criteria). Intra- and inter-AEMD were measured from parameters of tissue Doppler imaging. PWD was calculated from the 12-lead electrocardiogram. RESULTS Both inter-AEMD (22.9±15 vs. 11.5±14, p<0.001) and intra-AEMD (23.6±12 vs. 8.3±19, p<0.001) were found to be significantly longer in patients with MetS than the control group. Similarly, PWD (49±25 vs. 36±24, p=0.001) were found to be significantly longer in the MetS patients than the controls. However, both inter-AEMD and intra-AEMD and P wave measurements were not found to be associated with the severity of MetS. While inter and intra-AEMD were better correlated with LV mass index and LA volume index, PWD correlated better with mitral inflow Doppler parameters. According to multivariate analyses, inter-AEMD, HDL-C, and systolic and diastolic blood pressure were found to be independent predictors, whereas E/A and LDL-C had borderline significance. For the intra-AEMD, systolic and diastolic blood pressure, body mass index and E/A were found to be independent predictors. CONCLUSION In patients with MetS, inter- and intra-AEMD, and P dispersion were found to be lengthened when compared with the controls. However, these parameters were not associated with the severity of MetS.
Rural Finance and Private Farming in Romania

OUR RESEARCH WAS BASED LARGELY on two detailed surveys on the development of rural financial markets and private farming in Romania conducted during 1996-97 in response to an urgent need for greater agricultural finance on a more efficient and market-oriented basis in Romania. The analysis focused on the private farm and its relation to the financial market. Based on land title differences and organisational form of the farm, three private farming systems were distinguished. These are:
Dental prosthetic status and prosthetic needs of the institutionalized elderly living in geriatric homes in Hyderabad: a pilot study.

INTRODUCTION To promote oral health among the elderly, we need to know their prosthetic status and prosthetic need. Hence, a survey of prosthetic status and need of elderly inmates of geriatric homes in Hyderabad was done. MATERIALS AND METHODS A cross-sectional study was undertaken, and 174 subjects aged 60 years and above were examined of which 103 were male and 71 were female (59.2% males and 40.8% females). The oral examination of the study subjects was carried out using basic oral health surveys, WHO 1997 criteria. RESULTS Majority of the subjects, 73 (70.8%) males and 53 (74.6%) females had no prosthesis. Only 4.6% had complete dentures and 21.1% had removable partial dentures and 10.9% had single/multiple bridges. Need for any prosthesis was (83.5%) male and 63 (88.7%) female subjects and nearly 82. 8% subjects required one-unit prosthesis. CONCLUSION Dental prosthetic status of people living in geriatric homes is very poor and there is high unmet need for prosthetic care existed among the institutionalized elderly surveyed.
Preliminary analysis of the impulse breakdown characteristics of XLPE-covered cables used in compact distribution lines

This paper presents preliminary results related to the impulse breakdown characteristics of XLPE-covered cables. Tests with standard lightning impulse voltages (1.2/50 μs) applied to a typical single-phase structure employed in compact distribution lines used in Brazil were performed. Results in terms of breakdown voltage, time to breakdown and pinhole location are presented.
Small‐fibre neuropathy in female Fabry patients: reduced allodynia and skin blood flow after topical capsaicin

Abstract Fabry disease is a rare X‐linked lysosomal storage disorder. The mutations result in a deficiency of the lysosomal enzyme α‐galactosidase A causing accumulation of glycosphingolipids in the vascular endothelial cells and many other tissues. Given the X‐linked inheritance, male patients are severely affected. Recently, attention has been drawn to female patients whether they also show signs of nerve involvement. An early sign of the disease is painful small‐fibre neuropathy. The aim of this study was to evaluate a small‐fibre dysfunction in female Fabry patients by using capsaicin applied topically. The response to capsaicin was evaluated by laser Doppler imaging. We found that the female Fabry patients had a significantly smaller increase in blood flow (p = 0.0003) after capsaicin application. The area of static mechanical allodynia and dynamic mechanical hyperalgesia was also significantly smaller (p = 0.006) in female Fabry patients. This indicates that female Fabry patients have a significant loss of small‐fibre function and demonstrates that it is possible to evaluate this by a non‐invasive method.
Strategic marketing practices and the performance of Chinese small and medium-sized enterprises (SMEs) in Taiwan

This paper reports on a survey of the strategic marketing practices of 218 small and medium-sized enterprises (SMEs) in Taiwan. The survey's results indicate that while the higher performing Taiwanese SMEs give a higher priority to marketing than to other business functions in corporate planning, they are still sales- or production-oriented. The higher performing Taiwanese SMEs are more aware of strategic planning tools, but they make less use of them. They compete with value-added products and good buyer-seller relationships. The findings suggest that broad, small firm marketing principles, specifically generated from countries in the West, to some extent contribute to the success of Taiwanese SMEs. Interestingly, however, the specific marketing practices of these small firms are different from those of their Western counterparts. The research results provide additional evidence to support the theory that both Chinese cultural value orientations and mediating environmental factors play significant roles in shaping the attitudes and behaviour of Taiwanese owner-managers and, in turn, the marketing practices of Taiwanese SMEs.
STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

We provide unprecedented genetic and biochemical evidence that the antiapoptotic transcription factor STAT3 serves as a substrate for SYK tyrosine kinase both in vitro and in vivo. Induction of SYK in an ecdysone-inducible mammalian expression system results in STAT3 activation, as documented by tyrosine phosphorylation and nuclear translocation of STAT3, as well as amplified expression of several STAT3 target genes. STAT3 activation after oxidative stress (OS) is strongly diminished in DT40 chicken B-lineage lymphoma cells rendered SYK-deficient by targeted disruption of the syk gene. Introduction of a wild-type, C-terminal or N-terminal SH2 domain-mutated, but not a kinase domain-mutated, syk gene into SYK-deficient DT40 cells restores OS-induced enhancement of STAT-3 activity. Thus, SYK plays an important and indispensable role in OS-induced STAT3 activation and its catalytic SH1 domain is critical for this previously unknown regulatory function. These results provide evidence for the existence of a novel mode of cytokine-independent cross-talk that operates between SYK and STAT3 pathways and regulates apoptosis during OS. We further provide experimental evidence that SYK is capable of associating with and phosphorylating STAT3 in human B-lineage leukemia/lymphoma cells challenged with OS. In agreement with a prerequisite role of SYK in OS-induced STAT3 activation, OS does not induce tyrosine phosphorylation of STAT3 in SYK-deficient human proB leukemia cells. Notably, inhibition of SYK with a small molecule drug candidate prevents OS-induced activation of STAT3 and overcomes the resistance of human B-lineage leukemia/lymphoma cells to OS-induced apoptosis.
Cardinal Versus Ordinal Utility: António Horta Osório's Contribution

The history of economic thought remembers António Horta Osório for Schumpeter's reference to him in the History of Economic Analysis, in the context of a general appraisal of available works using mathematical instruments and language. This, however, does not do him justice, as he should also be praised for his pioneering interpretation of Pareto's general equilibrium. According to Stigler (1965), the definitive substitution of the cardinal utility hypothesis for the ordinal utility perspective was achieved by Johnson (1913) and Slutsky (1915). Weber (2001) discusses how far Pareto used cardinality, elects Slutsky (1915) as a pioneer of demand theory and prefers to reserve to R. G. Allen (1932–34), L. R. Klein and H. Rubin (1947–48), Samuelson (1947–48), R. C. Geary (1950–51), and Richard Stone (1954) the role of establishing ordinal utility in studying the utility function. This paper shows that Osório (1911) considered the subject of ordinalism before Johnson and Slutsky addressed the issue, as he had rejected the possibility of measuring utility and clearly stated that general equilibrium is not affected if cardinality is replaced by the ordinal conception for utility, according to Pareto's last formulation. Upon reading his book it becomes clear that not only was he perfectly aware of Edgeworth's contribution on the utility indifference curves, but also of Pareto's attempts to preserve general equilibrium from Fisher's criticism against cardinalism. Historians of economic thought have forgotten one of the early twentieth-century neoclassical economists. In this way the History of Economics has neglected an interesting proof of the consolidation of the Paretian ideas on ordinality, an issue that was an exciting and uncharted territory at that moment.
The Effects of Presentation Salience and Measurement Subjectivity on Nonprofessional Investors’ Fair Value Judgments

Fair value estimates reported in the financial statements differ in the subjectivity with which the estimates are measured. Mandated supplemental disclosures are intended to enable users to assess the nature of the inputs used to develop the fair value measurements, including their relative reliability, although prior research suggests some investors may have difficulty doing so. We draw on information processing research to predict and find that isolating fair value information in a separate column on the face of the income statement facilitates nonprofessional investors’ ability to incorporate into their perceived reliability and P/E judgments not only the fair value estimates, but also the disclosed measurement differences that underlie those estimates. Our results have implications for standard setters and researchers concerned with the effects of financial statement presentation on nonprofessional investors. Namely, we demonstrate how income statement presentation can improve reliance on mandated supplemental disclosures, thereby resulting in greater financial statement transparency.
Moving Forward by Looking Back: Comparing Laboratory Results with Ex Ante Market Data

We compare individual consumer response between ex ante market data collected by a water utility and ex post experimentally generated data. The experimentally generated data are matched to each participant's water bill history, which predates the experiment. This differentiates our research from prior efforts, which analyze market and experimental data with similar chronologies. For roughly 70% of the participants there is no statistical difference between water demand elasticities estimated using laboratory data and those estimated from market data. Our results provide initial support for the use of experimental procedures to generate missing data regarding hypothetical consumer response.