Miracle-dz/UniFAR-FTUs huggingface dataset:
Branching geometry of valley networks on Mars and Earth and its implications for early Martian climate

Valley network branching angles suggest that Mars’ ancient hydrology was not dominated by groundwater flow. Mars’ surface bears the imprint of valley networks formed billions of years ago. Whether these networks were formed by groundwater sapping, ice melt, or fluvial runoff has been debated for decades. These different scenarios have profoundly different implications for Mars’ climatic history and thus for its habitability in the distant past. Recent studies on Earth revealed that valley networks in arid landscapes with more surface runoff branch at narrower angles, while in humid environments with more groundwater flow, branching angles are much wider. We find that valley networks on Mars generally tend to branch at narrow angles similar to those found in arid landscapes on Earth. This result supports the inference that Mars once had an active hydrologic cycle and that Mars’ valley networks were formed primarily by overland flow erosion, with groundwater seepage playing only a minor role.
Lung Cancer: Preventable Disease.

Objective of the paper is to present lung cancer as preventable disease based on epidemiological, molecular and genomic data. Lung cancer is the most deadly malignancy around the world, both in male and female population. Vast majority of lung cancers (close to 90%) are directly caused by cigarette smoking, and thus present one of the most preventable deadly disease in humanity. Analysis of history of cigarette consumption and rise of lung cancer as world epidemics. Review of efforts to fight tobacco epidemics and how it influences incidence and prevalence of the lung cancer. Investigation of the effects of cigarette smoking on health and economic status of Bosnia and Hercegovina. Tobacco epidemics and lung cancer can be prevented. Goal is to exterminate cigarette smoking. That can be achieved only concerted effort by members of family, patients themselves, physicians, researchers, non-governmental organizations, political figures and society as a whole. CONCLUSION In country like Bosnia and Herzegovina first step is to inform society about devastating effects of cigarette smoking. Best practices already exist and initial goal should be to start using them.
World Endoscopy Organization Consensus Statements on Post-Colonoscopy and Post-Imaging Colorectal Cancer.

BACKGROUND & AIMS Colonoscopy examination does not always detect colorectal cancer (CRC)- some patients develop CRC after negative findings from an examination. When this occurs before the next recommended examination, it is called interval cancer. From a colonoscopy quality assurance perspective, that term is too restrictive, so the term post-colonoscopy colorectal cancer (PCCRC) was created in 2010. However, PCCRC definitions and methods for calculating rates vary among studies, making it impossible to compare results. We aimed to standardize the terminology, identification, analysis, and reporting of PCCRCs and CRCs detected after other whole-colon imaging evaluations (post-imaging colorectal cancers [PICRCs]). METHODS A 20-member international team of gastroenterologists, pathologists, and epidemiologists; a radiologist; and a non-medical professional met to formulate a series of recommendations, standardize definitions and categories (to align with interval cancer terminology), develop an algorithm to determine most-plausible etiologies, and develop standardized methodology to calculate rates of PCCRC and PICRC. The team followed the Appraisal of Guidelines for Research and Evaluation II tool. A literature review provided 401 articles to support proposed statements; evidence was rated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. The statements were voted on anonymously by team members, using a modified Delphi approach. RESULTS The team produced 21 statements that provide comprehensive guidance on PCCRCs and PICRCs. The statements present standardized definitions and terms, as well as methods for qualitative review, determination of etiology, calculation of PCCRC rates, and non-colonoscopic imaging of the colon. CONCLUSIONS A 20-member international team has provided standardized methods for analysis of etiologies of PCCRCs and PICRCs and defines its use as a quality indicator. The team provides recommendations for clinicians, organizations, researchers, policy makers, and patients.
Computed Tomographic Studies of Noncalcified Nodules Related to Neuroendocrine Lung Tumor Using 68Gallium-Tagged Somatostatin Variant for Improvement in Diagnosis: A Non-Experimental, Non-Randomized, Cross-Sectional Study

Background 18Fluoro-fluorodeoxyglucose (FDG)- based positron-emission computed tomography (PET) has less specificity for noncalcified nodules (NNs). Somatostatin receptors affect the expression of normal and malignant cells. The purpose of the study was to compare the sensitivity, specificity, and accuracy of 68Gallium-tagged DOTA-octreotate (Ga-tDO) with that of FDG PET for diagnosis of newly detected and/or untreated NNs in lung cancer patients. Material/Methods A total of 45 patients with lung cancer were included in the cross-sectional study and underwent Ga-tDO and FDG PET. We further confirmed observed outcomes by testing immune histochemical staining for subtype 2A of somatostatin receptor in a granuloma tissue array. The chi-square test was performed for sensitivity and specificity of predictive values among the 3 diagnostic modalities. McNemar’s test was performed to compare accuracy between Ga-tDO and FDG PET. Results were considered significant at 95% confidence level. Results Ga-tDO had less sensitivity (69% vs. 89%) but more specificity (91% vs. 78%) than FDG PET. Ga-tDO and FDG PET were characterized as 36 and 6 and in 36 and 3 lesions as accurate and inaccurate, respectively. There was an insignificant difference between Ga-tDO and FDG PET regarding diagnostic accuracy (p=0.7). Dosimetry results showed that the lungs were one of the least critically affected organs. Conclusions Ga-tDO was more specific but less sensitive than FDG PET scanning and imaging.
Non-classical monocytes as mediators of tissue destruction in arthritis

Objectives Bone destruction in rheumatoid arthritis is mediated by osteoclasts (OC), which are derived from precursor cells of the myeloid lineage. The role of the two monocyte subsets, classical monocytes (expressing CD115, Ly6C and CCR2) and non-classical monocytes (which are CD115 positive, but low in Ly6C and CCR2), in serving as precursors for OC in arthritis is still elusive. Methods We investigated CCR2−/− mice, which lack circulating classical monocytes, crossed into hTNFtg mice for the extent of joint damage. We analysed monocyte subsets in hTNFtg and K/BxN serum transfer arthritis by flow cytometry. We sorted monocyte subsets and analysed their potential to differentiate into OC and their transcriptional response in response to RANKL by RNA sequencing. With these data, we performed a gene ontology enrichment analysis and gene set enrichment analysis. Results We show that in hTNFtg arthritis local bone erosion and OC generation are even enhanced in the absence of CCR2. We further show the numbers of non-classical monocytes in blood are elevated and are significantly correlated with histological signs of joint destruction. Sorted non-classical monocytes display an increased capacity to differentiate into OCs. This is associated with an increased expression of signal transduction components of RANK, most importantly TRAF6, leading to an increased responsiveness to RANKL. Conclusion Therefore, non-classical monocytes are pivotal cells in arthritis tissue damage and a possible target for therapeutically intervention for the prevention of inflammatory joint damage.
Risk Factors Associated with Self-reported Sexually Transmitted Infections among Postsecondary Students in Canada

Background: Despite major public health efforts in addressing the burden of disease caused by sexually transmitted infections (STIs), rates among young adults continue to rise in Canada. The purpose of the study was to examine the prevalence and risk factors associated with acquiring STIs among postsecondary students in Canada. Methods: A secondary analysis of the American College Health Association-National College Health Assessment II-C Spring 2016 survey data (n = 43,780) was conducted. Sexually active participants (n = 28,831) were examined for their demographics, sexual behavior, alcohol and marijuana use, testing for human immunodeficiency virus (HIV), and human papillomavirus vaccination history. These factors were analyzed to help identify their possible association with acquiring an STI using logistic regression and multivariate modeling. Results: Among the study participants, 3.88% had an STI, with the highest rates observed among females and individuals aged 21–24 years old. Multivariate logistic analysis showed that participants who engaged in anal intercourse within the past 30 days (odds ratio [OR] = 1.634; 95% confidence interval [CI], 1.343–1.988), had four or more sexual partners in the last 12 months (OR = 4.223; 95% CI, 3.595–4.962), used marijuana within the past 30 days (OR = 1.641; 95% CI, 1.387–1.941), and had ever been tested for HIV (OR = 3.008; 95% CI, 2.607–3.471) had greater odds of acquiring an STI. Conclusions: The findings of this study highlight certain high-risk behaviors that are strongly associated with acquiring an STI among postsecondary students. Thus, efforts to design and deliver relevant educational programming and health promotion initiatives for this particular population are of utmost importance.
Association of Elevated C-Reactive Protein with Severe Periodontitis in Hypertensive Patients in Lagos, Nigeria: A Pilot Study

Background: Epidemiological studies have shown that individuals with chronic periodontitis have a significantly higher risk of developing cardiovascular complications, which might be attributed to the increased production of inflammatory cytokines initiated by the complex microbiota in dental biofilm. Aim: The study aims to evaluate the association between chronic periodontitis and C-reactive protein (CRP) levels in a group of hypertensive individuals in Nigeria. Materials and Methods: The investigator enrolled 50 hypertensive patients with chronic periodontitis into the study from the medical outpatient clinic of a teaching hospital in Lagos, Nigeria. Full-mouth periodontal examination was done to assess the participant's periodontal status, with probing depths and clinical attachment levels of six sites on all teeth. The investigator defined periodontitis as at least one interproximal site with probing depth ≥4 mm. Classification of participants into three groups was done based on their severity of periodontitis; mild (n = 16), moderate (n = 27), and severe (n = 7) periodontitis. Their CRP serum levels were measured, and the association with the severity of periodontitis was determined. P was found to be ≤ 0.05. Results: The median CRP levels were 1.0 (0.6, 2.2), 2.4 (1.1, 4.8), and 4.1 mg/L (3.3, 9.4) for mild, moderate, and severe chronic periodontitis, respectively. The association between the serum CRP levels and severity of periodontitis was statistically significant (P = 0.006). Conclusion: There was an association of elevated serum CRP level with increased severity of chronic periodontitis in hypertensive individuals. This preliminary finding among Nigerians suggests that chronic periodontal inflammation may contribute to systemic inflammatory burden in hypertensive patients.
Acute Effect of Oral N-Acetylcysteine on Muscle Soreness and Exercise Performance in Semi-Elite Rugby Players

ABSTRACT N-acetylcysteine (NAC) supplementation may enhance performance and reduce soreness from acute, repeated-sprint, high-intensity exercise. Our aim was to investigate whether semi-elite rugby union athletes may benefit. In a randomized block design, 17 semi-elite male rugby players were assigned to receive either 1 g oral NAC (n = 8) or placebo (n = 9) for six days. The mean percentage effect of NAC on exercise performance was assessed through completion of a broken bronco exercise test on days 5 and 6 of supplementation. Players self-reported muscle soreness and tolerability to supplements using a modified Muscle Pain and Treatment Satisfaction Questionnaire throughout the supplement duration. NAC produced a likely beneficial performance effect on maximum shuttle sprint time (2.4%; 90% confidence limit ± 4.8%) but was unclear on total time during back-to-back broken bronco tests compared to placebo. NAC had a likely protective effect on subjective muscle soreness during days 1–4 of supplementation (−19% ± 27%) but a very likely harmful effect on days 5 and 6 of supplementation (71% ± 59%). Daily supplementation with 1 g of oral NAC for six days produced no adverse side effects, reduced muscle soreness after one bout of damaging exercise, but increased soreness following the second bout. The performance effects were generally unclear apart from maximal sprint time.
Relational mobility predicts social behaviors in 39 countries and is tied to historical farming and threat

Significance Biologists and social scientists have long tried to understand why some societies have more fluid and open interpersonal relationships—differences in relational mobility—and how those differences influence individual behaviors. We measure relational mobility in 39 societies and find that relationships are more stable and hard to form in east Asia, North Africa, and the Middle East, while they are more fluid in the West and Latin America. Results show that relationally mobile cultures tend to have higher interpersonal trust and intimacy. Exploring potential causes, we find greater environmental threats (like disease and warfare) and sedentary farming are associated with lower relational mobility. Our society-level index of relational mobility for 39 societies is a resource for future studies. Biologists and social scientists have long tried to understand why some societies have more fluid and open interpersonal relationships and how those differences influence culture. This study measures relational mobility, a socioecological variable quantifying voluntary (high relational mobility) vs. fixed (low relational mobility) interpersonal relationships. We measure relational mobility in 39 societies and test whether it predicts social behavior. People in societies with higher relational mobility report more proactive interpersonal behaviors (e.g., self-disclosure and social support) and psychological tendencies that help them build and retain relationships (e.g., general trust, intimacy, self-esteem). Finally, we explore ecological factors that could explain relational mobility differences across societies. Relational mobility was lower in societies that practiced settled, interdependent subsistence styles, such as rice farming, and in societies that had stronger ecological and historical threats.
Comparative Evaluation of Remineralization Potential of Casein Phosphopeptide- Amorphous Calcium Fluoride Phosphate and Novamin on Artificially Demineralized Human Enamel: An In vitro Study

Aim: This study aimed to quantitatively compare the remineralization potential of casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) and Novamin on artificially induced enamel subsurface lesions using scanning electron microscope-energy dispersive X-ray (SEM-EDX). Materials and Methods: Enamel specimens were prepared from seventy caries-free premolars and were kept for demineralization for 4 days. Following demineralization, enamel specimens were assigned to three groups: (1) Control group, (2) Group with CPP-ACFP-containing toothpaste, and (3) Group with Novamin-containing toothpaste. Further, both the experimental groups (CPP-ACFP group and Novamin) were then divided into three subgroups based on the duration of re-mineralization as follows: (a) 7 days, (b) 14 days, and (c) 21 days. Enamel specimens of experimental groups were then subjected to SEM-EDX to evaluate mineral content after treating with CPP-ACFP and Novamin. Results: Both the experimental groups showed very high significant differences between Ca/P ratios of remineralized samples. Conclusion: Even though both CPP-ACFP and Novamin showed remineralization potential, remineralization was found to be higher in the samples treated with CPP-ACFP.
FARKLI BRANŞLARDAKİ SPORCULARIN DENGE PERFORMANSLARININ KARŞILAŞTIRILMASI

Bu calismanin amaci: Farkli yapisal ozellikler tasiyan uc ayri spor bransinin gerektirdigi denge duzeylerini tespit etmek ve branslara gore denge performanslarini karsilastirmaktir. Calismaya, halen aktif olarak spor yapan ve arastirmaya gonullu olarak katilmayi kabul 13 basketbolcu, 9 cimnastikci ve 13 futbolcu olmak uzere toplam 35 erkek sporcu dahil edilmistir. Deneklerin yas, boy ve vucut agirligi ortalamalari sirasiyla: basketbolcularda 20.85 yil, 192.25 cm ve 87.85 kg, cimnastikcilerde; 21.11 yil, 173.44 cm ve 66.16 kg, futbolcularda; 21.31 yil, 174.39 cm ve 70.07 kg’dir. Denekler, son bir yil icerisinde norolojik hastalik, vestibuler-vizuel rahatsizlik veya son 6 ay icerisinde ciddi bir alt ekstremite sakatligi gecirmemis bireylerden secilmislerdir. Denge olcumleri KAT 2000 (Kinesthetic Ability Trainer) ile gerceklestirilmistir. Her bir denegin dominant, nondominant, cift bacak statik test ve dinamik test skorlari olmak uzere toplam 4 ayri denge olcumu yapilmistir. Verilerin istatistiksel analizleri SPSS for Windows 11.0 paket programinda gerceklestirilmis ve anlamlilik seviyesi 0.05 olarak kabul edilmistir. Dominant ve nondominant bacak statik denge test skoru ile boy ve vucut agirligi arasinda, cift bacak statik denge test skoru ile sadece vucut agirligi arasinda anlamli duzeyde bir korelasyon tespit edilmistir (p<0.05). Basketbol ve Cimnastik branslari arasinda tum denge testlerinde istatistiksel olarak anlamli duzeyde farklilik tespit edilirken basketbol ve futbol branslari arasinda cift bacak statik denge skorunda ve cimnastik ile futbol branslari arasinda dinamik denge skorlari anlamli duzeyde farkli bulunmustur (p<0.05, p<0.01). Sonuc olarak: Cimnastikcilerin denge performansinin basketbolculara gore daha yuksek oldugu, futbolculara gore ise sadece dinamik denge performansinin daha gelismis oldugu saptanmistir. Futbolcularin denge performanslarinin hem basketbolculara hem de cimnastikcilere yakin oldugu, basketbolcularin ve futbolcularin denge yetisi bakimindan birbirine benzer ozelliklere sahip olduklari belirlenmistir
Carbamylated Hemoglobin can Differentiate Acute Kidney Injury from Chronic Kidney Disease

Carbamylated hemoglobin (CarHb) was found to have a potential role in the differentiation of patients with acute kidney injury (AKI) from chronic kidney disease (CKD). This study was aimed at the evaluation of the diagnostic performance and usefulness of CarHb in the differentiation of AKI from CKD. Forty patients with renal disease and twenty age- and sex-matched healthy controls were included in the study. Urea, creatinine, Hb, and CarHb were measured in all the subjects. Patients with AKI and CKD were found to have significantly increased levels of CarHb when compared to controls (P < 0.05 for both groups). Patients with CKD had significantly increased levels of CarHb when compared to patients with AKI (P < 0.05). CarHb showed significant positive correlation with urea in patients with renal disease (r = 0.776, P < 0.0001). Significant area under curve (AUC = 0.840, P < 0.0001) was obtained for CarHb and a cut-off value of 98.33 μg VH/g Hb resulted with the best combination of 85% sensitivity and 75% specificity. CarHb may provide clinical utility since patients with AKI and CKD have similar clinical presentation usually. A cut-off value of 98.33 μg VH/g Hb has been found to be useful to differentiate AKI from CKD.
Wide-Band Color Imagery Restoration for RGB-NIR Single Sensor Images

Multi-spectral RGB-NIR sensors have become ubiquitous in recent years. These sensors allow the visible and near-infrared spectral bands of a given scene to be captured at the same time. With such cameras, the acquired imagery has a compromised RGB color representation due to near-infrared bands (700–1100 nm) cross-talking with the visible bands (400–700 nm). This paper proposes two deep learning-based architectures to recover the full RGB color images, thus removing the NIR information from the visible bands. The proposed approaches directly restore the high-resolution RGB image by means of convolutional neural networks. They are evaluated with several outdoor images; both architectures reach a similar performance when evaluated in different scenarios and using different similarity metrics. Both of them improve the state of the art approaches.
Attachment as a Core Feature of Resilience: A Systematic Review and Meta-Analysis

Background Research has pointed to secure attachment as a possible key factor of resilience in adulthood. Objective We aimed to investigate the role of secure attachment as a potential core feature in the properties of resilience. Methods We conducted a systematic review in accordance with PRISMA guidelines followed by a meta-analysis. Results Thirty-three studies were included in the review, and 10 of these, including 2305 subjects, were used for meta-analysis. The raw correlation coefficients ranged from . 20 to . 57, which indicated weak to moderate correlations between resilience and attachment. The synthesized correlation coefficients indicated that the correlations were significant and highly unlikely to be due to random variation. All studies are also reported on qualitatively. Conclusions In both of our meta-analyses and in the narratively reported studies, we found that secure attachment is associated with the presence of resilience.