Miracle-dz/UniFAR-FTUs huggingface dataset:
Is TP53 mutation screening in Mantle Cell Lymphoma (MCL) ready for prime time?

Mantle cell lymphoma (MCL) is a rare incurable subtype of B-cell lymphoma characterized by t(11;14)(q13;q32)-driven over expression of cyclin D1 [1]. MCL is associated with the highest degree of genomic instability of the B cell malignancies, and TP53 mutation in particular confers a dismal prognosis in MCL with a reported incidence of 15-20 % (blastoid=29% vs Classical= 6%) [2, 3]. TP53 mutation status is the only independent molecular marker that was able to improve the prognostic value of the Mantle cell lymphoma International Prognostic Index (MIPI) [4]. MCL Patients with a TP53 mutation were significantly less likely to achieve a CR after first-line treatment and associated early relapse. The current standard of care, Chemo-immunotherapy with high-dose Cytarabine followed by autologous stem cell transplant (ASCT) (in eligible patient), although most patients prove ineligible, have failed to overcome the poor prognostic impact of TP53 disruption [4]. Ibrutinib and Venetoclax (ABT-199) are two of the most active agents in the treatment of MCL, they have acceptable toxicity profiles and mainly are used in relapse setting. Pre-clinical models predict synergy between these novel drugs in combination. Patients who received Ibrutinib after an initial relapse had significantly longer PFS and OS than patients who received Ibrutinib after successive relapses probably related to selective advantage of resistant clone expansion [5]. In MCL, the attention should be move to the upfront treatment setting using these target therapies in high risk disease (TP53 mutated) and elderly patients whom un-fit for chemo-immunotherapy approach and phase III clinical trial eagerly awaited to support this approach. Likewise, in chronic lymphocytic leukaemia (CLL) incorporating TP53 mutation screening in routine practice prior commencing therapy is paramount in the era of novel effective therapies. Younger MCL patients with this genetic alteration should be considered for specific treatment using inhibitors for BCR, BCL2, TP53-independent pathways, the Anti-CD20 monoclonal antibodies either alone or in combination followed by allogeneic stem cell transplantation in the upfront setting. Chemo-free approach also to be considered for un-fit patients early in the disease course. Fit un-mutated TP53 MCL Patients should be treated with chemo-immunotherapy with ASCT consolidation if eligible and anti CD20 monoclonal antibody maintenance therapy.
TRANSITION AND GAP MODELS OF FOREST DYNAMICS1

We describe and apply a correspondence between two major modeling approaches to forest dynamics: transition markovian models and gap models or JABOWAFORET type simulators. A transition model can be derived from a gap model by defining states on the basis of species, functional roles, vertical structure, or other convenient cover types. A gap-size plot can be assigned to one state according to dominance of one of these cover types. A semi-Markov framework is used for the transition model by considering not only the transition probabilities among the states, but also the holding times in each transition. The holding times are considered to be a combination of distributed and fixed time delays. Spatial extensions are possible by considering collections of gap-size plots and the proportions of these plots occupied by each state. The advantages of this approach include: reducing simulation time, analytica-l guidance to the simulations, direct analytical exploration of hypothesis and the possibility of fast computation from closed-form solutions and formulae. These advantages can be useful in the simulation of landscape dynamics and of species-rich forests, as well as in designing management strategies. A preliminary application to the H. J. Andrews forest in the Oregon Cascades is presented for demonstration.
FRUIT AND AGRICULTURAL WASTE CORTEX AS NATURAL RESINS ADSORBENTS FOR REMOVAL OF HEAVY METAL IONS FROM WASTE WATER

Agricultural waste peels, may act as cost effective and efficient adsorbents for the removal of heavy metals contaminates from waste water. raw peels of orange (Citrus sinensis ), lemon (Citrus limon), bitter orange (Citrus aurantium), broad bean (Vicia faba), pumpkin (Cucurbita pepo) and squash (Cocozzelle) biomass, have been used as a biosorbent for metal ion removal from synthetic waste aqueous solution by batch process. Fourier transforms infrared (FTIR) spectroscopy and scanning electron microscope techniques were used to characterize the Agricultural peels. The (FTIR) spectra showed that the intensities of functional groups after binding with metal ions were slightly reduced and also the peak positions were undergoes red shift. It had been found that the biosorption capacities were significantly affected by solution PH, contact time and particle size of peels. The best removal efficiency for Pb(II) was achieved by squash, while the higher removal efficiency for Cd(II) and Cu(II)was obtained by bitter orange and lemon respectively.
EVALUATION OF THE RESULTS OF CERVICAL SPINE & SPINAL CORD TRAUMA IN CHILDREN

Objectives Major differences exist in the anatomy and biomechanics of the growing spine that causes failure patterns different from those in adults. Spinal injury in the pediatric patient is a main concern because timely diagnosis and appropriate treatment can prevent further neurologic damage and deformity and potentiate recovery. We conducted a retrospective clinical study of 137 cases (93 boys, 44 girls) of pediatric cervical spine injuries, managed over fifteen years, to present data from a large series of pediatric patients with cervical spine injuries from a single regional trauma center. The aim was to assess and analyze complications, etiology, pathogenesis, site of injuries and age difference of cervical spine and spinal cord injury in a pediatric age group and compare the findings with current literature. Materials & Methods One hundred and thirty seven children with cervical spine injuries, seen over twelve years, were divided into two age groups: 54 patients were in group one (0-9 years ) and 83 patients were in group two (10 - 17 years) . We managed them according to status at presentation and type of injury. Forty seven patients were managed surgically and ninety nonsurgically (52 wore a halo brace and 38 wore different hard collars and braces). T-test and Chi squares were used to analyze differences between groups Results The most common cause of injury was motor vehicle accidents(MVA). Our younger patients (Group 1) had sustained more neurological injuries than the older ones (Group 2), 77% vs.48%. ; upper cervical spine was the most common site involved in 76%, while 43% suffered head injuries. In group two, 88% of children two sustained fractures or fracture/ subluxations; also in this group, subluxation, and fracture/ subluxation was present in 10 and 25% of children respectively. The most common radiological findings were vertebral fractures (38%). Solid fusions were demonstrated in all patients at late follow-up review (mean 6 years). None of the children developed neurological deterioration; however 18% mortality was documented. Various fusion techniques were used and neurological and fusion outcomes improved as compared with the previous reports. Conclusion Outcomes of cervical spine injuries in children are more positive than in adults, particularly in patients with incomplete injuries. The prognosis for children with complete spinal cord injuries, however, is still discouraging. Upper cervical spine injuries are more common between birth and 9 years of age; however fractures and fracture/subluxation are rare in this group. Surgical intervention with appropriate instrumentation and fusion are very effective in children with cervical spine instability.
Multilateration - source localization from range difference measurements: Literature survey

This is a brief literature survey on multilateration, the localization methods enabled by the range difference (RD) estimates. While the document primarily considers those obtained from the Time Difference Of Arrival (TDOA) measurements, in the context of sound source localization, the interest for such a review goes beyond acoustics. The discussed methods could be straightforwardly applied to, e.g. mapping problems in sensor networks, geolocalization by positioning systems and/or base stations, or to target localization in distributed radar signal processing.
The effect of acute care orientation coaching on perceived self-efficacy among new graduate nurses

This study explores the degree of perceived self-efficacy related to the performance of specific nursing behaviors among new graduate nurses who began their formal acute care institution orientation program in southeastern North Carolina during the summer of 2005. The theoretical framework for the study is Bandura’s Theory of Self-Efficacy (1997). A quasi-experimental single-group pretest, posttest design is used to examine self-efficacy perceptions of new graduate nurses across time and compare 6 nursing domains with various demographic characteristics. The study methods evaluate what influence prior nursing practice experience may have on self-perception of self-efficacy and to what degree the self-efficacy perceptions change over the course of 6 months. The study methods also evaluate for differences which may exist between self-efficacy perceptions within 6 nursing domains (Nurse-Client Relationship, Health Promotion, Illness/Injury Prevention, Curative/Supportive Care, Rehabilitative Care and Professional Practice) as measured by the Self-Efficacy for Professional Nursing Competencies Questionnaire (Babenko-Mould et al, 2004). There were 71 new nurse graduates who volunteered to complete the questionnaire during their first week of acute care institution orientation Forty of these new nurse graduates volunteered to complete the questionnaire again 6 months later. Significant differences (p<.001) in self-efficacy perceptions are found from pretest to posttest. These findings highlight the importance of the coaching activities for new graduate nurses and validate self-efficacy sources as proposed in Bandura’s theory. Insights gained from this study may assist nursing educators in planning curricula, clinical experiences, and orientation programs to meet learning needs of nursing students in preparation for the new graduate nurse role.
OTT_A_198542 4055..4063

Department of Cellular and Molecular Biology, Beijing Chest Hospital, Capital Medical University /Beijing Tuberculosis and Thoracic Tumor Research Institute, Tongzhou, Beijing, People’s Republic of China Background: Tropomyosin 4 (TPM4) is a member of the tropomyosin family of actinbinding proteins. Abnormal level of TPM4 is found in several cancers, and TPM4 is considered as a potential detecting marker for ovarian cancer, breast cancer, colon cancer, keratoacanthoma and esophageal squamous cell carcinoma. In this paper, the function of TPM4 in lung cancer cell lines was determined. Materials and methods: TPM4 knockout cells were constructed by CRISPR/CAS9 technique. TPM4 overexpression cells were also constructed based on TPM4 knockout cells. Cell growth ability was detected by MTS assay. The potency of cell motility was investigated using transwell assay and wound scratch assay. The protein levels in lung cancer cells were determined by western-blot. Immunofluorescence technique was used to image the structure of F-actin. Results: As a result, TPM4 downregulation and TPM4 upregulation cell models were obtained successfully. Cell motility was inhibited by the suppression of TPM4 while cell migration was enhanced in TPM4 upregulated cells. But TPM4 was not involved in cell proliferation and EMT progression. Microfilaments were depolymerized result from the suppression of TPM4 expression. And F-actin assembly was increased when TPM4 was upregulated. Conclusion: In summary, TPM4 was able to promote cell motility by altering the actin cytoskeleton directly.
Neutralization Escape Variants of Human Immunodeficiency Virus Type 1 Are Transmitted from Mother to Infant

Neutralization Escape Variants of Human Immunodeficiency Virus Type 1 Are Transmitted from Mother to Infant Xueling Wu, Adam B. Parast, Barbra A. Richardson, Ruth Nduati, Grace John-Stewart, Dorothy Mbori-Ngacha, Stephanie M. J. Rainwater, and Julie Overbaugh* Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109; Departments of Biostatistics and Medicine, University of Washington, Seattle, Washington 98104; and Department of Pediatrics, University of Nairobi, Nairobi, Kenya
Longitudinal evaluation of Tau‐P301L transgenic mice reveals no cognitive impairments at 17 months of age

Tau is a microtubule‐associated binding protein implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD). These diseases result in the intracellular accumulation of hyperphosphorylated tau in the form of neurofibrillary tangles, the presence of which is associated with cognitive deficits.
RRU_A_194679 165..174

Department of Urology, Usl Toscana Sud Est, San Donato Hospital, Arezzo, Italy Abstract: Male chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is represented by a heterogeneous group of symptoms that can cause an important impairment of daily quality of life for patients. Diagnosis of CP/CPPS is often not clear and treatment can be challenging, as it varies according to the different causative factors and derived symptoms. Differently from approaches used in the past, the diagnosis and subsequent treatment rely on separating this entity from chronic bacterial prostatitis and considering it as a multifactorial disease. Autoimmunity and inflammation, myofascial tenderness, neuroinflammation, and psychological causes have been clearly related to this disease, and therefore CPPS should not only be considered as related to benign prostatic enlargement. A multitude of different symptoms related to urinary, genital, rectal, and perineal areas can be attributed to this condition and therefore should be routinely investigated in patients, as well as possible differential diagnoses which can cause the same symptoms, such as pudendal nerve entrapment syndrome. The aim of this narrative review is to focus on CPPS after an infectious cause has been excluded.
Studies of carcino‐fetal proteins: Physical and chemical properties of human α‐fetoprotein

To obtain information on the relationship between a carcino‐fetal protein, α‐fetoprotein, fetal proteins from other species and other human serum proteins including the fetoprotein in patients with hepatocellular cancer, α‐fetoprotein was purified and characterized from the serum of human fetuses. The protein is composed of a single polypeptide chain. A molecular weight of 70,000 was obtained by gel electrophoresis in the presence of SDS and by gel filtration. The isoelectric point of α‐fetoprotein was found to be 4.75. It contains 4.3% carbohydrate with 2 moles of sialic acid per mole of protein. The amino acid composition of α‐fetoprotein was determined.
A study of clinical teachers ’ attitude to teaching and perceived learning needs in a medical college in Nigeria

Background and purpose: Debates on medical educational reform initiatives in Nigeria have gradually shifted from access to medical colleges to improving learning quality. Understandably, clinical teachers are being encouraged to acquire basic teaching pedagogical knowledge through learning activities. Considering the fact that the concept of faculty development for medical teachers ’ is still evolving in Sub-Saharan Africa, this study aims to explore clinical teachers ’ attitude to teaching and perceptions of continuing education in teaching knowledge and skills in a medical college in Nigeria. Methods: Using a mixed-method research approach, quantitative data were collected from a sample of teachers through survey questionnaires, and qualitative data were obtained through face-to-face individual semi-structured interviews of teachers from the same institution. Results: Sixty-one survey questionnaires (response rate of 88%) and 10 interviews were completed and analyzed. Findings revealed that teachers ’ derived satisfaction from teaching and maintain a strong commitment to teaching. Bedside teachings (64%) and lectures (21%) were reported to be the most frequent mode of teaching. Although four out of every ﬁ ve respondents (80%) reported not having previous training in teaching, a large proportion (97%) self-assessed their teaching abilities to be average or above average, with most indicating that the experience of teaching observed during undergraduate medical training may be suf ﬁ cient preparation for their teaching roles. The majority of the teachers' were of the opinion that there is a need to improve their individual teaching skill. However, in the absence of formal faculty development programs in the college, most of the teachers indicated that their teaching skills are currently being improved through sporadic informal community of practice involving interested colleagues and modeling identi ﬁ ed good teachers. Conclusion: A catalyst of learning by teachers ’ may come from their belief and self-rating of teaching ability. In this under-resourced context, explicit classi ﬁ cations of existing informal learning opportunities coupled with greater institutional support could improve teaching and teachers ’ development.
International Journal of Recent Technology and Engineering (IJRTE)

Recently, volunteering has become a global trend and the number of volunteers has increased significantly at special events. Sports events are the most common special events which can be defined as a function or "occasion" that aims to raise money for the community or the non-profit group that organizes it, in terms of fundraising. There are many types of special events, each with its own complexity and relevance to different groups. Many sporting events rely on volunteers who play a crucial role in the success of an event. It is therefore the responsibility of the organizer and the management to understand the motivation and satisfaction of the volunteers, which will lead to new volunteers for future sporting events. Understanding the motivations of volunteers and ensuring that they can successfully accomplish the different roles required to achieve their goals is challenging. In order to recruit and retain enough volunteers at sporting events, it is important to understand clearly motivating factors that lead to volunteer satisfaction, to develop a successful volunteer retention strategy so that the organizer can recruit and keep enough volunteers at sporting events. Nevertheless, with these limitations, this study will highlight the motivational factors that can affect volunteering. The researcher's project should therefore build on the ideas that emerge from the theory of self-determination (SDT). The SDT is applied in this conceptual research paper to discuss the volunteers’ motivation to volunteer for special sporting event using VMS-ISE motivation scale. The volunteers' satisfaction with volunteering at special sporting events is also measured. This research ends with a conceptual framework in which motivational factors and the satisfaction of volunteers are discussed.
An observational, prospective study of the pharmaco- invasive strategy approach to ST-segment myocardial infarction (STEMI) in the era of primary percutaneous coronary intervention based on Elias Heart Centre Interventional Registry (EIRE Study). The Southern Romanian experience

An observational, prospective study of the pharmacoinvasive strategy approach to ST-segment myocardial infarction (STEMI) in the era of primary percutaneous coronary intervention based on Elias Heart Centre Interventional Registry (EIRE Study). The Southern Romanian experience Liviu-Nicolae Ghilencea1,2, Andreea–Catarina Popescu1,2, Doina Dimulescu1,2, Sean Maher1,2, Ali Al Hassan2, Adrian Linte2, Ionut Stanca2, Mihai Melnic2, Sergiu Barsan2, Cristian Bejan1, Laura Arama2, Brandusa Zamfirescu2, Stefanita Petrea2, Cristian Gîrgel2, Maria-Lorena Roamba2, Simona Huidu2, Luminita Ionescu2, Raluca Aflorii2, Andreea Rachieru2, Maria Marinescu2, Elena Lechea2, Nicoleta Tascan2, Constantin Stefani1, Alexandrina Nastasa2, Livia Trasca1,2, Lavinia Matei1,2, Adrian Mereuta1,3, Serban Balanescu1,2
18-25 YAŞ GRUBU BAYANLARDA DİNAMİK GERDİRME EGZERSİZLERİNİN ESNEKLİKLERİNE ETKİSİ / THE EFFECTS OF DINAMIC STRECHING EXERCISES TO THE FLEXBILITY OF THE FEMALES 18-25 AGE GROUPS

Bu calismanin amaci genc bayanlann LO haftalik dinamik germe egzersizleri sonrasi esneklik degisikliklerini ortaya cikarmaktir. Calismaya yaslari 20,30 oliln 10 sedanter bayan gonullu olarak katilmistir. Egzersiz oncesi ve sonrasi sirasi ile otur-uzan, sag ve sol diz tleksiyon, spagat, kol esnekligi, omuz ekstansiyon ve tleksiyon, kalca ekstansiyon ve tleksiyon, govde one tleksiyon, geriye ekstansiyon ve koprli esnekligi olcumleri almdi. Degiskenlerin aritmetik ortalama, standart sapmalari ile birlikte on ve son test degerleri t-testi analizi p<0.05 anlamlilik duzeyinde incelendi. Bu olcumlerden on-test ve son test sonucunda deneklerin otur-uzan, sag ve sol diz fleksiyon, spagat, kol esnekligi, omuz ekstansiyon ve fleksiyon, kalca ekstansiyon, govde one tleksiyon, govde geriye ekstansiyon ve kopiii esnekligi degerlerinde p<0.05 seviyesinde anlamli bir degisme gozlenirken, kalca fleksiyon degerlerinde onemli bir degisiklik gozlenmedi. Anahtar Kelimeler: Esneklik. Dinamik Gerdimie ABSRACT in [his srudy, it iS aimed to establish the body fat percent changes and flexibility changes in young women after ten week static streching exercises. Ten volunteer women whose age average is 20,70 particapated in ihe study. Before and after the exercise. sit-extend, right and left knee flexibility, , spare- Cul, ann elasticity, shoulder extensibilty and flexibility, and flexibility, hip extensibility and flexibility, body fol"\'1ard bending, body back bending and body fat percent measurments were taken. Varinnts of arilhmetical averages and standart deviations with the first and last lest values were exainined at the levet oft-test analysis P< 0.05 i t is absiiacted from the results of the first and the last test measunnents to be charming changes in sit extend, left and right knee flexibility, spare- eut, arin elaslicity, shonlder extensibilty and flexibility, hip extensibility, body forward bending, body back bending values at the level of P<0.05 of test takers but no clear changes in hip flexibility. Key Words: Flexibility, Static exercise