Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of nitrogen, phosphorus and potassium availability on emergence, nodulation and growth of Trifolium medium L. in alkaline soil.

Little is known about the effects of nutrient availability on the growth of Trifolium medium in alkaline soil. In 2010, a pot experiment (10 N, P and K fertiliser treatments) with seeding of T. medium into alkaline soil was performed and emergence of seedlings, survival, aboveground and belowground organs were studied. The positive effects of increased nutrient availability on seedling emergence ranged from 5% in the control to 17% in the high P treatment. The lowest mortality was in treatments with P and K supply and the highest in treatments with N supply, due to the sensitivity of young plants to high N availability. The highest values of most measured aboveground plant traits were recorded in treatments with simultaneous application of N, P and K. There were highly positive effects of P supply alone or in combination with N and K on the development of belowground organs. Taproot length ranged from 11.5 in high N to 40.2 cm in P treatment. There was a negative effect of N application on nodulation, especially in N treatments, where growth of T. medium was limited by insufficient P supply. The number of nodules per plant ranged from 0.8 to 4.5 in the high N and P treatments. As demonstrated in this study, T. medium is a potentially suitable legume for alkaline soils. It requires a relatively high P and K supply as well as moderate mineral N supply to achieve its maximum growth potential.
Development of Thermal Resistant FDM Printed Blends. The Preparation of GPET/PC Blends and Evaluation of Material Performance

The paper discusses the preparation of polymer blends based on the polyethylene terephthalate copolymer/polycarbonate (GPET/PC). Materials have been prepared in order to assess their applicability in the fused deposition modeling (FDM) 3D printing process. The tested key feature was the thermomechanical resistance, measured by head deflection temperature (HDT) and Vicat softening temperature (VST), the mechanical tests and dynamic mechanical thermal analysis (DMTA) were also performed. A clear relationship between the increasing content of PC in the blend properties was observed. DMTA analysis revealed significant changes in the glass transition temperature, which indicates the miscibility of this type of polymer system. The mechanical tests indicate a clear trend of stiffness and strength improvement along with the increasing share of PC phase in the structure. The increase in impact strength is also clear, however, compared to the results for a pure PC, the results obtained for GPET/PC blends are significantly lower. As part of the research, reference samples based on polyethylene terephthalate homopolymer (PET) and composite samples with addition of 10% talc were also prepared. The structure analysis for PET/PC(50/50) samples did not show miscibility. However, due to the formation of the PET crystalline phase, the thermomechanical resistance of these materials was visibly higher. Scanning electron microscopy (SEM) analysis confirmed a high degree of compatibility of the GPET/PC blend structure as indicated by the lack of visible signs of phase separation. This phenomenon is not observed for PET/PC blends, which confirms the different thermomechanical interactions of both tested polymer systems.
Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging.

BACKGROUND Accurate quantification of mitral valve (MV) morphology and dynamic behavior over the cardiac cycle is crucial to understand the mechanisms of degenerative MV dysfunction and to guide the surgical intervention. Cardiac magnetic resonance (CMR) imaging has progressively been adopted to evaluate MV pathophysiology, although a dedicated framework is required to perform a quantitative assessment of the functional MV anatomy. METHODS We investigated MV dynamic behavior in subjects with normal MV anatomy (n=10) and patients referred to surgery due to degenerative MV prolapse, classified as fibro-elastic deficiency (FED, n=9) and Barlow's disease (BD, n=10). A CMR-dedicated framework was adopted to evaluate prolapse height and volume and quantitatively assess valvular morphology and papillary muscles (PAPs) function over the cardiac cycle. Multiple comparison was used to investigate the hallmarks associated to MV degenerative prolapse and evaluate the feasibility of anatomical and functional distinction between FED and BD phenotypes. RESULTS On average, annular dimensions were significantly (P<0.05) larger in BD than in FED and normal subjects while no significant differences were noticed between FED and normal. MV eccentricity progressively decreased passing from normal to FED and BD, with the latter exhibiting a rounder annulus shape. Over the cardiac cycle, we noticed significant differences for BD during systole with an abnormal annular enlargement between mid and late systole (LS) (P<0.001 vs. normal); the PAPs dynamics remained comparable in the three groups. Prolapse height and volume highlighted significant differences among normal, FED and BD valves. CONCLUSIONS Our CMR-dedicated framework allows for the quantitative and dynamic evaluation of MV apparatus, with quantifiable annular alterations representing the primary hallmark of severe MV degeneration. This may aid surgeons in the evaluation of the severity of MV dysfunction and the selection of the appropriate MV treatment.
Prevention of iodine deficiency disorders by oral administration of lipiodol during pregnancy.

The prevalence of iodine deficiency disorders and the thyroid status of the population were studied in an endemic goitre area in Algeria. After oral administration of lipiodol (0.5 ml), three treated groups of mother-newborn couples were compared to an untreated group: group A, mothers treated 1-3 months before conception; group B, mothers treated during the first month of pregnancy; group C, mothers treated during the third month of pregnancy. Untreated mothers were used as a control (group D). After lipiodol treatment, all newborn babies and mothers were clinically euthyroid. All tested newborn babies were full term and no goitre was observed in the four groups. In the mothers, goitre prevalence and thyrotrophin levels decreased significantly, whereas maternal milk and urinary iodine and serum-free thyroxine levels were significantly higher after treatment. The rate of prematurity, stillbirths and abortions in the treated groups was reduced when compared to the untreated group, whereas placental and birth weights were significantly higher. In group D two cases of neonatal hypothyroidism were detected. Their re-evaluation confirmed that hypothyroidism was transient. Groups A, B and C were statistically different from group D with regard to neonatal thyrotrophin and thyroxine. Positive correlations were found between neonatal thyroxine and birth weights and placental weights on the one hand, and maternal urinary iodine and free thyroxine on the other. Consequently, these data indicate that oral administration of lipiodol before or during the first trimester of pregnancy normalizes thyroid function in newborn babies and mothers, increases placental and birth weight and reduces the frequency of iodine deficiency disorders. (ABSTRACT TRUNCATED AT 250 WORDS)
Effects of Varying Levels of Fungal (Arachniotus sp.) Treated Wheat Straw as an Ingredient of Total Mixed Ration on Growth Performance and Nutrient Digestibility in Nili Ravi Buffalo Calves

The study was carried out to explore the effects of replacing wheat straw with fungal treated wheat straw as an ingredient of total mixed ration (TMR) on the growth performance and nutrient digestibility in Nili Ravi buffalo male calves. Fungal treated wheat straw was prepared using Arachniotus sp. Four TMRs were formulated where wheat straw was replaced with 0 (TMR1), 33 (TMR2), 67 (TMR3), and 100% (TMR4) fungal treated wheat straw in TMR. All TMRs were iso-caloric and iso-nitrogenous. The experimental TMRs were randomly assigned to four groups of male calves (n = 6) according to completely randomized design and the experiment continued for four months. The calves fed TMR2 exhibited a significant improve in dry matter intake, average daily weight gain, feed conversion ratio and feed economics compared to other groups. The same group also showed higher digestibility of dry matter, crude protein, neutral-, and acid detergent fibers than those fed on other TMRs. It is concluded that TMR with 33% fungal-treated wheat straw replacement has a potential to give an enhanced growth performance and nutrient digestibility in male Nili Ravi buffalo calves.
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response

ABSTRACT FANCJ mutations are linked to Fanconi anemia (FA) and increase breast cancer risk. FANCJ encodes a DNA helicase implicated in homologous recombination (HR) repair of double-strand breaks (DSBs) and interstrand cross-links (ICLs), but its mechanism of action is not well understood. Here we show with live-cell imaging that FANCJ recruitment to laser-induced DSBs but not psoralen-induced ICLs is dependent on nuclease-active MRE11. FANCJ interacts directly with MRE11 and inhibits its exonuclease activity in a specific manner, suggesting that FANCJ regulates the MRE11 nuclease to facilitate DSB processing and appropriate end resection. Cells deficient in FANCJ and MRE11 show increased ionizing radiation (IR) resistance, reduced numbers of γH2AX and RAD51 foci, and elevated numbers of DNA-dependent protein kinase catalytic subunit foci, suggesting that HR is compromised and the nonhomologous end-joining (NHEJ) pathway is elicited to help cells cope with IR-induced strand breaks. Interplay between FANCJ and MRE11 ensures a normal response to IR-induced DSBs, whereas FANCJ involvement in ICL repair is regulated by MLH1 and the FA pathway. Our findings are discussed in light of the current model for HR repair.
The specificity of neutralizing antibodies to feline leukaemia viruses

Feline leukaemia viruses (FeLV) of subgroups A (FeLV‐A), B (FeLV‐B) and C (FeLV‐C) were examined by neutralization. The FeLV‐A isolates were monotypic. By contrast, there was antigenic variation within subgroups B and C. There was also considerable cross‐reactivity between subgroups. Thus, FeLV‐A viruses showed weak cross‐reactivity to the standard FeLV‐C isolate; four of the subgroup B viruses were identical and cross‐reacted with the standard FeLV‐C, but not with FeLV‐A or the fifth FeLV‐B, and this latter virus weakly cross‐reacted with FeLV‐A but not with the FeLV‐C; within subgroup C, one virus was indistinguishable from the standard FeLV‐C strain but the other two were very similar to FeLV‐A. Therefore, subgroup classification based on interference did not altogether correspond with neutralizing behaviour for subgroups B and C.
Lung cancer in which the hypothesis of multi-step progression is confirmed by array-CGH results: A case report

The pathogenesis of lung cancer has not been fully elucidated and biological markers acting as predictors of tumor evolution and aggressiveness remain unidentified. The multi-step hypothesis, suggesting a progression from adenomatous hyperplasia (AAH) to adenocarcinoma (AC) through bronchioalveolar carcinoma (BAC), was highlighted in a previous cytogenetic study performed in a single case. The present study reports the results of an array-comparative genomic hybridization (a-CGH) analysis performed on the DNA obtained from the previously reported case that presented AAH, BAC and AC in one lung. The a-CGH results confirm and support the previous cytogenetic observations with new data, clearly supporting the hypothesis of a multi-step carcinogenic process in the lung.
Early Peritonitis in a Large Peritoneal Dialysis Provider System in Colombia

♦ Background: Peritonitis is the most important complication of peritoneal dialysis (PD), and early peritonitis rate is predictive of the subsequent course on PD. Our aim was to calculate the early peritonitis rate and to identify characteristics and predisposing factors in a large nationwide PD provider network in Colombia. ♦ Methods: This was a historical observational cohort study of all adult patients starting PD between January 1, 2012, and December 31, 2013, in 49 renal facilities in the Renal Therapy Services in Colombia. We studied the peritonitis rate in the first 90 days of treatment, its causative micro-organisms, its predictors and its variation with time on PD and between individual facilities. ♦ Results: A total of 3,525 patients initiated PD, with 176 episodes of peritonitis during 752 patient-years of follow-up for a rate of 0.23 episodes per patient year equivalent to 1 every 52 months. In 41 of 49 units, the rate was better than 1 per 33 months, and in 45, it was better than 1 per 24 months. Peritonitis rates did not differ with age, ethnicity, socioeconomic status, or PD modality. We identified high incidence risk periods at 2 to 5 weeks after initiation of PD and again at 10 to 12 weeks. ♦ Conclusion: An excellent peritonitis rate was achieved across a large nationwide network. This occurred in the context of high nationwide PD utilization and despite high rates of socioeconomic deprivation. We propose that a key factor in achieving this was a standardized approach to management of patients.
Injury among female and male army parachutists.

BACKGROUND While military parachuting injuries have been well studied, the relationship between gender and risk of injury has not. Injuries among women may be different due to anatomic and physiologic differences, or due to exposure to different jump conditions. Training methods and equipment developed for men may not be as effective in preventing injuries among women. HYPOTHESIS We hypothesize that the nature and distribution of parachute injuries will vary by gender. METHODS This descriptive retrospective study used 10 yr of parachute injury data reported to the U.S. Army Safety Center at Fort Rucker, AL, and exposure data obtained from the Defense Manpower Data Center, Monterey, CA. RESULTS Women appear to jump under less hazardous conditions (jump more often than men in daylight and in static-line, non-tactical environments), yet appear to be at greater risk of serious injury, particularly lower extremity fractures. Injured male parachutists are more likely to experience upper extremity injury. Women's injuries are more likely to be the result of an improper parachute landing fall or parachute malfunction, while men are more likely to be injured due to ground hazards. CONCLUSIONS There are some provocative gender differences in patterns of injury. Further research is indicated starting with a comprehensive, prospective study, controlling for physical fitness and exposure differences, as well as for potential reporting bias, in order to better understand the apparent differences in reported injuries.
Dense networks within a group help bridging networks between groups : interchange of people between mountainous and urban areas

People embedded in dense social networks are likely to trust and cooperate with other members of their group. However, these individuals are also likely to turn inward and harbor strong hostility toward groups outside their network. Thus, it is important to establish bridging networks between groups. However, the effect of dense networks within a group on bridging networks between groups remains unclear. To elucidate the relationships between dense and bridging networks within and between groups, this study interviewed residents of the village of Nishiawakura in a mountainous region of Okayama Prefecture, Japan. We asked participants about their networks within the village and with urban residents. We found that established residents who had lived in the village for a long time maintained dense networks within the village to preserve their forests. Recently, however, these dense networks have not worked efficiently in a consistent manner. Returners (i.e., those who had returned from urban areas) were not embedded in the dense networks within the village and their forests had not been well preserved. However, they were more eager to form bridging networks with urban residents, hoping that urban residents would manage the abandoned forests in the village. On the other hand, established residents were skeptical about the effect of urban-mountain communications on the village. In this context, the dense networks of the established residents might have inhibited the development of bridging networks between this population and urban residents. However, the staff of the Mokkun Company is now developing bridging networks between the two groups. These are possible, in part, because staff members acknowledge the importance of the dense networks within the village. Hence, dense networks within a group might also help in the establishment of bridging networks between groups under certain conditions.
Loss of desmin triggers mechanosensitivity and up‐regulation of Ankrd1 expression through Akt‐NF‐κB signaling pathway in smooth muscle cells

Muscle cells, including human airway smooth muscle cells (HASMCs) express ankyrin repeat protein 1 (Ankrd1), a member of ankyrin repeat protein family. Ankrd1 efficiently interacts with the type III intermediate filament desmin. Our earlier study showed that desmin is an intracellular load‐bearing protein that influences airway compliance, lung recoil, and airway contractile responsiveness. These results suggest that Ankrd1 and desmin may play important roles on ASMC homeostasis. Here we show that small interfering (si)RNA‐mediated knockdown of the desmin gene in HASMCs, recombinant HASMCs (re‐HASMCs), up‐regulates Ankrd1 expression. Moreover, loss of desmin in HASMCs increases the phosphorylation of Akt, inhibitor of κB kinase (IKK)‐α, and inhibitor of κB (IκB)‐α proteins, leading to NF‐κB activation. Treatment of reHASMCs with Akt, IKKα, IKBα, or NF‐κB inhibitor inhibits the loss of desmin‐induced Ankrd1 up‐regulation, suggesting Akt/NF‐κB‐mediated Ankrd1 regulation. Transfection of reHASMCs with siRNA specific for p50 or p65 corroborates the NF‐κB‐mediated Ankrd1 regulation. Luciferase reporter assays show that NF‐κB directly binds on Ankrd1 promoter and up‐regulates Ankrd1 levels. Overall, our data provide a new link between desmin and Ankrd1 regulation, which may be important for ASMC homeostasis. —Mohamed, J. S. , Boriek, A. M. Loss of desmin triggers mechanosensitivity and up‐regulation of Ankrd1 expression through Akt‐NF‐κB signaling pathway in smooth muscle cells. FASEB J. 26, 757–765 (2012). www.fasebj. org
A HIGH PANEL-REACTIVE ANTIBODY RESCUE PROTOCOL FOR CROSS-MATCH-POSITIVE LIVE DONOR KIDNEY TRANSPLANTS1

Background. Alloimmunization can present a virtually insurmountable barrier to kidney transplantation. Past protocols to desensitize patients using plasmapheresis and cyclophosphamide have not been broadly applied because of the fear of complications, including high rates of immunologic failure. Methods. Fifteen patients with a positive donor-recipient cross-match were desensitized with plasmapheresis to permit live donor (LD) transplantation under newer maintenance immunosuppressants. Pretransplant the patients received plasmapheresis three times weekly for a planned maximum of six treatments, plus intravenous hyperimmune globulin, tacrolimus, mycophenolate mofetil, and prednisone. Patients who were successfully desensitized and received transplants were given 10 days of OKT3 postoperatively. Results. Eleven of the 15 patients became anti-human globulin cross-match-negative after one to five plasmapheresis treatments and underwent LD transplantation. Relatively low initial titers of donor-specific antibody were predictive of successful attainment of a negative cross-match. Few side effects and rejection episodes were observed. All transplant patients remain dialysis-free after 3–26 months of follow-up. Conclusion. A positive cross-match is not necessarily a contraindication to LD transplantation, especially for patients with low donor-specific alloantibody titers.
THE SURVIVAL CON: FRAUD AND FORGERY IN THE REPUBLIC OF BIAFRA, 1967–70*

Abstract Over the course of the Nigerian Civil War (1967–70), many people in the secessionist Republic of Biafra resorted to forgery, confidence scams, and other forms of fraud to survive the dire conditions created by Nigeria's blockade. Forgery of passes and other documents, fraudulent commercial transactions, and elaborate schemes involving impersonation and racketeering became common in Biafra, intensifying as the Biafran government's ability to enforce the law diminished. Using long-neglected legal records from Biafra's courts and tribunals, this study traces the process by which deception emerged as a practice of survival in wartime Biafra – a process with important implications for the growth of fraud (known as ‘419’ after the relevant section of the Nigerian criminal code) in reintegrated postwar Nigeria.
Phosphorylation of GluR4 AMPA‐type glutamate receptor subunit by protein kinase C in cultured retina amacrine neurons

We have previously reported that the activity of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionate (AMPA) receptors is potentiated by protein kinase C (PKC) in cultured chick retina amacrine neurons, and that constitutive PKC activity is necessary for basal AMPA receptor activity ( Carvalho et al., 1998 ). In this study, we evaluated the phosphorylation of the GluR4 subunit, which is very abundant in cultured amacrine neurons, to correlate it with the effects of PKC on AMPA receptor activity in these cells. 32P‐labelling of GluR4 increased upon AMPA receptor stimulation or cell treatment with phorbol 12‐myristate 13‐acetate (PMA) before stimulating with kainate. By contrast, phosphorylation of GluR4 was not changed when PKC was inhibited by treating the cells with the selective PKC inhibitor GF 109203X before stimulation with kainate. We conclude that GluR4 is phosphorylated upon PKC activation and/or stimulation of AMPA receptors in cultured amacrine cells. Additionally, AMPA receptor activation with kainate in cultured chick amacrine cells leads to translocation of conventional and novel PKC isoforms to the cell membrane, suggesting that PKC could be activated upon AMPA receptor stimulation in these cells.