Miracle-dz/UniFAR-FTUs huggingface dataset:
Experience-dependent mushroom body plasticity in butterflies: consequences of search complexity and host range

An ovipositing insect experiences many sensory challenges during her search for a suitable host plant. These sensory challenges become exceedingly pronounced when host range increases, as larger varieties of sensory inputs have to be perceived and processed in the brain. Neural capacities can be exceeded upon information overload, inflicting costs on oviposition accuracy. One presumed generalist strategy to diminish information overload is the acquisition of a focused search during its lifetime based on experiences within the current environment, a strategy opposed to a more genetically determined focus expected to be seen in relative specialists. We hypothesized that a broader host range is positively correlated with mushroom body (MB) plasticity, a brain structure related to learning and memory. To test this hypothesis, butterflies with diverging host ranges (Polygonia c-album, Aglais io and Aglais urticae) were subjected to differential environmental complexities for oviposition, after which ontogenetic MB calyx volume differences were compared among species. We found that the relative generalist species exhibited remarkable plasticity in ontogenetic MB volumes; MB growth was differentially stimulated based on the complexity of the experienced environment. For relative specialists, MB volume was more canalized. All in all, this study strongly suggests an impact of host range on brain plasticity in Nymphalid butterflies.
'I love teaching ESL' - constructions of ESL teacher work and identity

Within the constraints which surround our work, it is the notion of self as teacher, or understandings of our teacher identity, which inform all that we do. The data which form the basis of the study come from interviews conducted with twenty ESL teachers working in the government secondary school system in Victoria. The constructions of English as a Second Language (ESL) teacher work and identity which emerge are cause for both celebration and concern, offering a view of ESL teacher work as both more useful and less onerous than other forms of teaching.
Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study

Objective To study the association between wheezy symptoms in young children and the presence of bacteria in the airways. Design Birth cohort study. Setting Clinical research unit in Copenhagen. Participants Children of asthmatic mothers, from age 4 weeks to 3 years, with planned visits and acute admissions to the research clinic. Main outcome measure Frequency of bacteria and virus carriage in airway aspirates during wheezy episodes and at planned visits without respiratory symptoms. Results 984 samples (361 children) were analysed for bacteria, 844 (299 children) for viruses, and 696 (277 children) for both viruses and bacteria. Wheezy episodes were associated with both bacterial infection (odds ratio 2.9, 95% confidence interval 1.9 to 4.3; P<0.001) and virus infection (2.8, 1.7 to 4.4; P<0.001). The associations of bacteria and viruses were independent of each other. Conclusion Acute wheezy episodes in young children were significantly associated with bacterial infections similar to but independent of the association with virus infections.
Taking the TESOL Practicum Abroad: Opportunities for Critical Awareness and Community-Building among Preservice Teachers

This chapter examines the experiences of four native English-speaking preservice teachers in a faculty-led study abroad program in South Korea. It elucidates the ways in which these preservice teachers experienced personal and professional growth with an increasing critical awareness of the power imbalance embedded in English language teaching in the global context. Data were collected via students’ weekly online discussion posts, electronic portfolio artifacts, and focus group interviews. Findings indicate personal and professional growth in participants’ self-perceptions as a result of at least two fundamental aspects of the program: 1) the intentionality with which participants were exposed to a critique of English language teaching in the Korean context and 2) the residential nature of the experience, which provided intensive peer collaboration among practicum participants. The chapter concludes with recommendations for implementing a TESOL practicum abroad as a meaningful and consciousness-raising opportunity for preservice teachers’ professional development. Taking the TESOL Practicum Abroad: Opportunities for Critical Awareness and Community-Building among Preservice Teachers
Functional &bgr;-Cell Mass and Insulin Sensitivity Is Decreased in Insulin-Independent Pancreas-Kidney Recipients

Background. To compare functional &bgr;-cell mass and insulin sensitivity in insulin-independent pancreas-kidney recipients with that in age- and body mass index-matched nondiabetic kidney recipients and normal controls. Methods. All transplant recipients were on maintenance immunosuppression with mycophenolate mofetil and tacrolimus since more than 2.7 years (2.2–3.8 years). Their C-peptide release was measured during a 170-min hyperglycemic clamp, first in absence and then in presence of glucagon. Data were compared with those after glucose stimulation alone. Insulin sensitivity under basal and stimulated conditions was calculated using homeostasis model assessment of insulin resistance and insulin sensitivity index, respectively. Results. Functional &bgr;-cell mass in pancreas-kidney recipients with systemic venous drainage was reduced, representing, respectively, 63% and 80% of that in healthy controls and kidney recipients. Pancreas-kidney recipients exhibited lower insulin sensitivity than healthy controls (homeostasis model assessment of insulin resistance was 0.8, 0.7–1.1 vs. 0.4, 0.3–0.8; P=0.02 and insulin sensitivity index was 17, 12–24 mg/kg/min per 100 &mgr;U/mL vs. 31, 20–38 mg/kg/min per 100 &mgr;U/mL; P=0.04). Conclusions. Using a hyperglycemic clamp, the functional &bgr;-cell mass in insulin-independent pancreas-kidney recipients was found to be 37% and 20% lower than in healthy controls and nondiabetic kidney recipients.
Adult Cochlear Implant Patient Performance with Evolving Electrode Technology

Objective In 1998, clinical trials were initiated to evaluate the CLARION Multi-Strategy Cochlear Implant (Advanced Bionics Corp., Sylmar, CA, U.S.A.), a precurved electrode with an electrode positioning system (EPS) in adults with severe to profound hearing impairments. In 1999, clinical trials were initiated to assess the CLARION HiFocus electrode with EPS in a similar group of adults. The purpose of this retrospective study was to evaluate and compare the preoperative and 1-, 3-, and 6-month postoperative speech perception scores obtained by the first 56 patients implanted with the precurved electrode with EPS and the first 56 patients implanted with the HiFocus electrode with EPS. Speech strategy preferences were additionally noted and compared at each test interval for each group. Study Design All subjects participated in preoperative testing with hearing aids and postoperative (1, 3 and 6 months) testing with either the precurved electrode with EPS or the HiFocus electrode with EPS. Demographic characteristics and preoperative and postoperative speech perception results were compared within and between the 2 groups. Setting Data presented here were collected at cochlear implant programs affiliated with tertiary medical centers located in the United States and Canada that participated in the clinical trials. Patients Patients were postlinguistically deafened adults who received a CLARION cochlear implant. Results and Conclusion Within-group evaluations revealed that both groups demonstrated significant improvements on all speech perception measures when 1-month postoperative scores were compared with scores obtained preoperatively with hearing aids. Between-group comparison of demographic data showed that the HiFocus group had a significantly higher mean age at implant and a significantly longer mean duration of deafness than the precurved electrode with EPS group. Statistical comparison of mean speech perception scores showed no significant difference between subjects using the precurved electrode with EPS versus the HiFocus electrode with EPS at the preoperative, 1-, and 3-month test intervals. At the 6-month test interval, the mean CNC Monosyllabic Word Test score obtained by the HiFocus with EPS group was significantly better than the mean score obtained by the group with the precurved electrode with EPS (p < 0.05).
Cocaine Constrictor Mechanisms of the Cerebral Vasculature

Abstract: Cocaine constriction of the cerebral vasculature is thought to contribute to the ischemia associated with cocaine use. However, the mechanisms whereby cocaine elicits relevant vasoconstriction remain elusive. Indeed, proposed intra- and intercellular mechanisms based on over 3 decades of ex vivo vascular studies are, for the most part, of questionable relevancy due to the generally low contractile efficacy of cocaine combined with the use of nonresistance-type vessels. Furthermore, the significance attached to mechanisms derived from in vivo animal studies may be limited by the inability to demonstrate cocaine-induced decreased cerebral blood flow, as observed in (awake) humans. Despite these apparent limitations, we surmise that the vasoconstriction relevant to cocaine-induced ischemia is elicited by inhibition of dilator and activation of constrictor pathways because of cocaine action on the neurovascular unit (neuron, astrocyte, and vessel) and on vessels outside the unit. Furthermore, previous cocaine exposure, that is, conditions present in human subjects, downregulates and sensitizes these dilator and constrictor pathways, respectively, thereby enhancing constriction to acute cocaine. Identification of specific intra- and intercellular mechanisms requires investigations in the isolated microvasculature and the neurovascular unit from species chronically exposed to cocaine and in which cocaine decreases cerebral blood flow.
Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus.

We examined the ability of an equivalent increase in circulating glucose concentrations to inhibit endogenous glucose production (EGP) and to stimulate glucose metabolism in patients with Type 2 diabetes mellitus (DM2). Somatostatin was infused in the presence of basal replacements of glucoregulatory hormones and plasma glucose was maintained either at 90 or 180 mg/dl. Overnight low-dose insulin was used to normalize the plasma glucose levels in DM2 before initiation of the study protocol. In the presence of identical and constant plasma insulin, glucagon, and growth hormone concentrations, a doubling of the plasma glucose levels inhibited EGP by 42% and stimulated peripheral glucose uptake by 69% in nondiabetic subjects. However, the same increment in the plasma glucose concentrations failed to lower EGP, and stimulated glucose uptake by only 49% in patients with DM2. The rate of glucose infusion required to maintain the same hyperglycemic plateau was 58% lower in DM2 than in nondiabetic individuals. Despite diminished rates of total glucose uptake during hyperglycemia, the ability of glucose per se (at basal insulin) to stimulate whole body glycogen synthesis (glucose uptake minus glycolysis) was comparable in DM2 and in nondiabetic subjects. To examine the mechanisms responsible for the lack of inhibition of EGP by hyperglycemia in DM2 we also assessed the rates of total glucose output (TGO), i.e., flux through glucose-6-phosphatase, and the rate of glucose cycling in a subgroup of the study subjects. In the nondiabetic group, hyperglycemia inhibited TGO by 35%, while glucose cycling did not change significantly. In DM2, neither TGO or glucose cycling was affected by hyperglycemia. The lack of increase in glucose cycling in the face of a doubling in circulating glucose concentrations suggested that hyperglycemia at basal insulin inhibits glucose-6-phosphatase activity in vivo. Conversely, the lack of increase in glucose cycling in the presence of hyperglycemia and unchanged TGO suggest that the increase in the plasma glucose concentration failed to enhance the flux through glucokinase in DM2. In summary, both lack of inhibition of EGP and diminished stimulation of glucose uptake contribute to impaired glucose effectiveness in DM2. The abilities of glucose at basal insulin to both increase the flux through glucokinase and to inhibit the flux through glucose-6-phosphatase are impaired in DM2. Conversely, glycogen synthesis is exquisitely sensitive to changes in plasma glucose in patients with DM2.
Multiplex PCR for the detection and identification of dairy bacteriophages in milk

Bacteriophage infections of starter lactic acid bacteria are a serious risk in the dairy industry. Phage infection can lead to slow lactic acid production or even the total failure of fermentation. The associated economic losses can be substantial. Rapid and sensitive methods are therefore required to detect and identify phages at all stages of the manufacture of fermented dairy products. This study describes a simple and rapid multiplex PCR method that, in a single reaction, detects the presence of bacteriophages infecting Streptococcus thermophilus and Lactobacillus delbrueckii, plus three genetically distinct ‘species’ of Lactococcus lactis phages commonly found in dairy plants (P335, 936 and c2). Available bacteriophage genome sequences were examined and the conserved regions used to design five pairs of primers, one for each of the above bacteriophage species. These primers were designed to generate specific fragments of different size depending on the species. Since this method can detect the above phages in untreated milk and can be easily incorporated into dairy industry routines, it might be readily used to earmark contaminated milk for use in processes that do not involve susceptible starter organisms or for use in those that involve phage-deactivating conditions. r 2006 Elsevier Ltd. All rights reserved.
Grants Vs . Investment Subsidies

How should a government intervene to help the credit constrained poor? We study an economy where productivity and wealth are unobserved, and loans must be collateralized. We show that the e¢cient policy typically consists of o¤ering both a grant and an investment subsidy. Everybody will take the grant and only the relatively productive will take the subsidy. This policy reduces but does not eliminate investment distortions.
Ten-year outcome of subthalamic stimulation in Parkinson disease: a blinded evaluation.

OBJECTIVE To assess the 10-year motor outcome of deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson disease (PD). DESIGN Patients with PD with bilateral STN-DBS were assessed according to the Core Assessment Program for Surgical Interventional Therapies in Parkinson's Disease protocol and videotaped at baseline and 1, 5, and 10 years after surgery. An independent rater blinded to stimulation and medication condition scored the 10-year video assessments. SETTING Movement Disorders Centre, Toronto Western Hospital, University Health Network, University of Toronto. PATIENTS Eighteen patients with advanced PD and 10-year follow-up of STN-DBS. INTERVENTION Bilateral STN-DBS surgery. MAIN OUTCOME MEASURES The primary outcome was the change in blinded Unified Parkinson's Disease Rating Scale (UPDRS) motor scores/subscores between the no medication/stimulation condition vs the no medication/no stimulation condition at 10 years. Secondary outcomes were the changes in blinded UPDRS motor scores between the medication/no stimulation and medication/stimulation conditions, UPDRS II scores, UPDRS IV dyskinesia and motor fluctuations scores, and anti-PD medication dose (levodopa equivalent daily dose) at different points. RESULTS In the 18 patients available for follow-up at 10 years, STN-DBS still significantly improved the UPDRS total motor score (P = .007) and resting and action tremor (P < .01 and P = .02, respectively) and bradykinesia (P = .01) subscores. The UPDRS II scores in the medication and no medication conditions, UPDRS IV dyskinesia and motor fluctuations scores, and the levodopa equivalent daily dose were also significantly reduced compared with baseline. Axial signs showed the most progressive decline in stimulation and levodopa response over the years. CONCLUSION This class III study provides evidence that stimulation-induced motor improvement was sustained overall at 10 years, although part of the initial benefit wore off mainly because of progressive loss of benefit on axial signs over time.
Pharmacokinetics of intravenous fusidic acid in patients with cholestasis

The pharmacokinetics of fusidic acid and 3-ketofusidic acid were investigated in cholestatic and noncholestatic patients after intravenous administration of single and multiple doses of 500 mg of sodium fusidate. The patients, all with low serum albumin levels, were divided into three groups. Group I consisted of six noncholestatic patients; group II consisted of nine mildly cholestatic patients with mild hepatic impairment (conjugated bilirubin, 47 mumol liter-1; alkaline phosphatase, 280 IU liter-1; gamma-glutamyltranspeptidase, 190 IU liter-1); group III consisted of six benign intrahepatic cholestatic patients with high isolated conjugated hyperbilirubinemia (98.1 mumol liter-1). Assays were performed by high-pressure liquid chromatography. At steady state, the mean peak concentrations in serum were 63.7, 44.9, and 92.2 micrograms ml-1 in groups I, II, and III, respectively; over a dosage interval, areas under the concentration-time curve were 411.1, 238.7, and 603.4 micrograms.h ml-1 and the mean body clearances were 0.34, 0.53, and 0.25 ml min kg-1 in groups I, II, and III, respectively. The accumulation ratio of fusidic acid increased from 2.8 and 2.4 in groups I and II to 4.2 in group III. At steady state, the ratios of the areas under the concentration-time curve from 0 to 8 h for 3-ketofusidic acid/fusidic acid were 0.11, 0.09, and 0.10 in the three groups, respectively. Only very small amounts of fusidic acid and 3-ketofusidic acid were found in urine. These results substantiate the following hypotheses. In group I and II patients the clearance is higher than that in healthy volunteers because of the increased free, unbound fraction of fusidic acid, a consequence of lower serum albumin concentrations, resulting in increased distribution in tissue and hepatic metabolism. In group III patients, the higher bilirubinemia results in competition with fusidic acid for the limited glucuronidation, thus compensating for the increased elimination with fusidic acid because of the low serum albumin concentration. These results suggest that fusidic acid can be administered normally even to patients with high bilirubinemia because the postoperative serum albumin concentration is usually low.
Macroeconomic Shocks and Corporate R&D

Abstract This paper investigates the impact of output and credit market shocks on R&D spending in advanced economies and builds on the commonly accepted view that credit constraints lead to procyclical R&D spending. A theoretical model is developed where output and credit shocks are treated separately, though these shocks may be highly correlated. The estimation procedure utilizes a panel vector autoregression (VAR) in order to empirically identify the role of credit market shocks separately from the output shocks more commonly studied in the existing literature. The primary empirical findings can be summarized as follows: (1) R&D responds pro-cyclically to output shocks at the macroeconomic level, and (2) R&D co-moves positively with credit. More concretely, the results indicate that negative output shocks induce a simultaneous and subsequent contraction in credit and R&D consistent with a model where credit constraints drive cyclical adjustments to R&D. The impact of output and credit shocks on R&D are economically significant and a simulation exercise suggests the shocks associated with the global financial crisis have reduced US R&D by 10% relative to the pre-crisis path.
A Multiple‐station Test of the Teaching Skills of General Practice Preceptors in Flanders, Belgium

Purpose The Interuniversity Center for Education in General Practice in Flanders, Belgium, supervises its general practice (GP) preceptors so they will meet the quality criteria required for their role in training general practitioners. The author developed a teaching skills assessment test to determine the individual preceptors' competence regarding teaching. The preliminary research described in this article, carried out in 1999, aimed to verify the reliability, validity, and acceptability of that multiple-station test. Method The test consists of seven stations in which simulated teaching situations are portrayed. In the present study, in each station, the GP preceptors (n = 35) had a learning conversation with a standardized GP trainee. The teaching situations were (1) drawing up a learning agenda, (2) leading an advisory conversation, (3) having an exchange of information about practice visits, (4) having a case-related discussion, (5) having a feedback conversation, (6) giving a demonstration of a particular skill or technique, and (7) having an intermediate evaluation conversation. In each station two observers independently scored the preceptors on a five-point scale. Results The preceptors' scores on the entire test ranged from 30 to 82.7 on a scale whose maximum was 100. The average score was 54.4 (SD, 11.6), and the average scores on the various stations fluctuated between 51.2 and 57.7. The interobserver reliability varied from good to very good for five of the seven stations (Pearson r = 0.77-0.92). The separate stations had a good internal consistency (Cronbach alpha = 0.85). Based on these research results only, the content validity and acceptability of the instrument are good for the GP preceptors in Flanders. Conclusions The study findings suggest that the teaching skills assessment test is a reliable instrument, especially fit for screening GP preceptors' teaching skills. However, validation of the instrument needs further investigation.
Expectations and achievements in new firms

Purpose The purpose of this paper is to investigate the antecedents of business growth expectations and subsequent accumulated sales revenues and employment costs. Hypotheses are derived guided by the theory of planned behaviour. Design/methodology/approach The authors followed a sample of 207 incorporated businesses started in May/June 2002 over a ten-year period. The hypotheses are tested using hierarchical regression analysis. Findings The results suggest that the entrepreneurs’ need for social cohesion, subjective norm with regard to business growth and perceived self-efficacy with regard to opportunity recognition are positively and significantly associated with business growth expectations. These expectations, reported at the time of business registration, accurately predict subsequent short-term as well as long-term accumulated sales revenues and labour costs, but this is not the case for entrepreneurs with novel business ideas. Practical implications Since entrepreneurs’ attitude, subjective norm and self-efficacy are possible to change, the findings should interest policy makers and educators. Measures aimed at enhancing the antecedents of entrepreneurs’ growth expectations should be considered. The findings that growth expectations have a long-lasting effect on sales and employment stress the importance of entrepreneurs’ subjective expectations for outcomes in new businesses. Originality/value There is a lack of studies using a longitudinal design when investigating the link between initial business growth expectations and subsequent firm outcomes. This study contributes to the entrepreneurship literature in this regard by using high-quality secondary data to examine firm achievements.