Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparing specialist early years provision for speech and language impaired children with mainstream nursery provision in the UK - an application of the Early Childhood Environment Rating Scale (ECERS).

BACKGROUND This study examines the application of the Early Childhood Environment Rating Scale (ECERS) to specialist early years provision for children with developmental speech and language impairment. The scale, which has been used in the national Effective Provision of Pre-school Education (EPPE) study in the UK comprises seven subscales describing the quality of provision along a continuum centred on the following areas: 'space and furnishings', 'personal care routines', 'language reasoning', 'activities', 'interaction', 'program structure', and 'parents and staff'. METHODS The ECERS was applied to two nurseries funded by the UK charity I CAN by two researchers with inter-rater-reliability coefficients ranging from 0.91 to 0.96. RESULTS There were notable differences between the specialist early years provision and 'average' nursery provision in the UK. On 7/8 measures the early years centre scores are markedly higher than average pre-school provisions. The standard of education and care for the pre-school provisions included in the EPPE project ranged from below minimal (for the diversity subscale, ECERS-E) to approaching good (for the space and furnishings subscale). In contrast, the early years centres were rated as between minimal to good on areas such as space and furnishings and good to excellent on all other areas. CONCLUSIONS Clearly specialist services such as those described offer something different from the average. Given results which suggest the positive effects on the children's language abilities of such services it is quite possible that the distinctive characteristics of the nursery environment are responsible for the positive impact. There is a good case for extending the application of the ECERS as a way of helping those providing specialist services start to detect the active ingredients of the provision.
Educating Men About Prostate Cancer in the Workplace

Prostate cancer is a common cancer affecting men worldwide. Few men access health services with respect to early detection. Workplace health education initiatives can promote behavior change in men. A total of 12 in-depth interviews with men were conducted in this study to examine how a workplace-based educational campaign on prostate cancer influences the knowledge, awareness, and beliefs of male workers on screening for prostate cancer. Analyses of interview transcripts identified that men had a poor overall knowledge about prostate cancer, its screening, and treatment. Participants were receptive to the introduction of workplace-based health education initiatives to promote men’s health issues but recommended an integrated health approach that incorporated information delivered by medical professionals, cancer survivors, supplemented with existing patient education materials. Further research is required to formally evaluate the impact of workplace-based education strategies on men’s health.
M opsin phosphorylation in intact mammalian retinas

The deactivation of visual pigments involved in phototransduction is critical for recovering sensitivity after exposure to light in rods and cones of the vertebrate retina. In rods, phosphorylation of rhodopsin by rhodopsin kinase (GRK1) and the subsequent binding of visual arrestin completely terminates phototransduction. Although signal termination in cones is predicted to occur via a similar mechanism as in rods, there may be differences due to the expression of related but distinct gene products. While rods only express GRK1, cones in some species express only GRK1 or GRK7 and others express both GRKs. In the mouse, cone opsin is phosphorylated by GRK1, but this has not been demonstrated in mammals that express GRK7 in cones. We compared cone opsin phosphorylation in intact retinas from the 13‐lined ground squirrel (GS) and pig, cone‐ and rod‐dominant mammals, respectively, which both express GRK7. M opsin phosphorylation increased during continuous exposure to light, then declined between 3 and 6 min. In contrast, rhodopsin phosphorylation continued to increase during this time period. In GS retina homogenates, anti‐GS GRK7 antibody blocked M opsin phosphorylation by 73%. In pig retina homogenates, only 20% inhibition was observed, possibly due to phosphorylation by GRK1 released from rods during homogenization. Our results suggest that GRK7 phosphorylates M opsin in both of these mammals. Using an in vitro GTPγS binding assay, we also found that the ability of recombinant M opsin to activate Gt was greatly reduced by phosphorylation. Therefore, phosphorylation may participate directly in the termination of phototransduction in cones by decreasing the activity of M opsin.
Changing temperature and precipitation extremes in the Hindu Kush‐Himalayan region: an analysis of CMIP3 and CMIP5 simulations and projections

The Hindu Kush‐Himalayan (HKH) region epitomizes a geographic region where cryospheric processes coupled with hydrological regimes are under threat owing to a warming climate and shifts in climate extremes. In this study, we analyse global climate models in the Coupled Model Intercomparison Project phase 3 (CMIP3) and phase 5 (CMIP5) archives to investigate the qualitative aspects of change and trends in temperature and precipitation indices. Specifically, we examine and evaluate multi‐model, multi‐scenario climate change projections and seven extreme temperature and precipitation indices over the eastern Himalaya (EH) and western Himalaya‐Karakoram (WH) regions for the 21st century. Density distribution plots of observed climate indices for meteorological stations and gridded indices are also analysed, which indicate significant negative trends in the annual number of frost days and significant increasing trends in warm nights in the EH region over the 1960–2000 period. Multi‐model average (MMA) projections additionally indicate continued trends towards more extreme conditions consistent with a warmer, wetter climate. Precipitation projections indicate increased mean precipitation with more frequent extreme rainfall during monsoon season in the EH region, and a wetter cold season in the WH region. Time series of all MMA precipitation indices exhibit significant increasing trends over the 1901–2099 period. By comparison, time series of temperature indices show decreases in the intra‐annual extreme temperature range and total number of frost days, as well as increases in warm nights. In general, these future projections point towards increases in summertime temperatures and modifications in precipitation across both regions.
Second Messenger Function of Nicotinic Acid Adenine Dinucleotide Phosphate Revealed by an Improved Enzymatic Cycling Assay*

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent activator of Ca2+ release from intracellular stores known today. Although recent reports have suggested an important function of NAADP in human T lymphocytes, direct evidence for receptor-induced formation of NAADP is yet missing in these cells. Thus, we developed a highly sensitive and specific enzyme assay capable of quantifying low fmol amounts of NAADP. In unstimulated T cells, the NAADP concentration amounted to 4.4 ± 1.6 nm (0.055 ± 0.028 pmol/mg of protein). Stimulation of the cells via the T cell receptor/CD3 complex resulted in biphasic elevation kinetics of cellular NAADP levels and was characterized by a bell-shaped concentration-response curve for NAADP. In contrast, the NAADP concentration was elevated neither upon activation of the ADP-ribose/TRPM2 channel Ca2+ signaling system nor by an increase of the intracellular Ca2+ concentration upon thapsigargin stimulation. T cell receptor/CD3 complex-mediated NAADP formation was dependent on the activity of tyrosine kinases because genistein completely blocked NAADP elevation. Thus, we propose a regulated formation of NAADP upon specific stimulation of the T cell receptor/CD3 complex, suggesting a function of NAADP as a Ca2+-mobilizing second messenger during T cell activation.
The Adoption of Spreadsheet Software: Testing Innovation Diffusion Theory in the Context of End-User Computing

Judging by the wealth of problems reported in the literature, information systems (IS) and general managers are not sure how to manage the introduction of new information technology. One step toward providing sound management guidelines is to improve understanding of the social forces which affect the introduction and diffusion process within organizations. This research takes a step toward that goal by examining the validity of innovation diffusion theory within the context of end-user computing. The research involved a field study and historical analysis of the diffusion of spreadsheet software in organizations. To assist in controlling exogenous factors, only finance and accounting departments were studied. Over 500 professionals in 24 business units from 18 large businesses in manufacturing and services participated in the research. Findings supported hypotheses that earlier adopters of spreadsheet software were younger, more highly educated, more attuned to mass media, more involved in interpersonal communication, and more likely to be opinion leaders. Also supported was the hypothesized sigmoidal distribution of adoption over time. Application of the theory was not supported in all areas, however, suggesting that information technology diffusion is different from other diffusion phenomena. Contrary to theory, interpersonal channels of communication were dominant in all phases of adoption decision making. And contrary to their hypothesized role as change agent, IS departments played a minor role in the diffusion process. This was consistent with the observed user-led nature of the phenomenon. Implications for research and practice are discussed.
Polyphase orthogonal waveform optimization for MIMO-SAR using Genetic Algorithm

A Multi-Input Multi-Output (MIMO) radar can be used to form a synthetic aperture for high resolution imaging. To successfully utilize the MIMO Synthetic Aperture Radar (SAR) system for practical imaging application, the orthogonal waveform design plays a critical role in image formation. Focusing on the SAR application, a definition for synthetic Integrated Side-Lobe level Ratio (ISLR) is proposed. In this paper a cost function containing ISLR and Peak Side-Lobe level Ratio (PSLR) is presented. A Genetic Algorithm (GA) is presented to numerically optimize orthogonal polyphase code sets design. The obtained waveform can be implemented for MIMO-SAR systems to improve the resolution. The simulation results show that the superiority of the proposed algorithm over other algorithms for the design of polyphase code sets used in MIMO-SAR.
Customer participation in creating site brand loyalty

This article explores the development of an e-business marketing model that capitalizes on customer participation and the likely consequences of such efforts, principally site brand loyalty. A conceptual model illustrates how consumers’ goals in visiting a website (task or experiential) affect their propensity to be site brand loyal and how characteristics of the site, including personalization and community, are related to brand loyalty. The model also shows that creating site brand loyalty leads to predictable affective, cognitive, and behavioral outcomes from customers, such as repeat visits to and patronage of the site, fewer intentions to defect to competitors, and more favorable attitudes toward the site. Case studies of corporate websites provide empirical evidence to support the model. The paper concludes by suggesting that customer participation in the e-business model fundamentally changes the way brands are developed. That is, producers no longer create an image for a brand and pass it on to the consumer; instead, the producer and consumer are interactively creating the e-business brand.
Differences in Neuropsychological Performance Associated With Ethnicity in Children With HIV-1 Infection: Preliminary Findings

This study investigated the relationship between ethnicity (African American and European American) and neuropsychological performance in two specific neuropsychological domains (language and speed of information processing) in a group of HIV-1+ children. The Expressive One-Word Picture Vocabulary Test-Revised and the Rapid Color Naming subtest of the Comprehensive Test of Phonological Processing were administered to 5- to 7-year-old children (n = 22) as part of a comprehensive research or clinical protocol. African American children scored lower than European American children (p < .05) on both procedures. The observed performance difference emerged despite the fact that there were no group differences in age, immunologic clinical categories, intellect, level of maternal education, or CD4+ percentage and after using stringent exclusionary criteria, including history of enrollment in special education services and the presence of other chronic medical conditions. The implications of such findings are discussed within biological and demographic frameworks.
Staging of liver fibrosis in chronic hepatitis B patients with a composite predictive model: a comparative study.

AIM To evaluate the efficacy of 6 noninvasive liver fibrosis models and to identify the most valuable model for the prediction of liver fibrosis stage in chronic hepatitis B (CHB) patients. METHODS Seventy-eight CHB patients were consecutively enrolled in this study. Liver biopsy was performed and blood serum was obtained at admission. Histological diagnosis was made according to the METAVIR system. Significant fibrosis was defined as stage score > or = 2, severe fibrosis as stage score > or = 3. The diagnostic accuracy of 6 noninvasive liver fibrosis models, including serum aspartate aminotransferase (AST) to platelet ratio index (APRI), FIB-4, Forn's index, Fibrometer, Hepascore, and Shanghai Liver Fibrosis Group's index (SLFG), was investigated. RESULTS The APRI, FIB-4 and Forn's index under receiver operating characteristic curve (AUROC) for significant fibrosis were 0.71, 0.75 and 0.79, respectively, with a diagnosis accuracy of 67%, 77% and 80%, respectively, and 0.80, 0.87 and 0.86, respectively, under the AUROC for severe fibrosis. The Hepascore, SLFG, and Fibrometer were 0.80, 0.83 and 0.85, respectively under the AUROC for significant fibrosis (P < 0.01). The diagnosis accuracy of Hepascore and SLFG was 86% and 88%, respectively. The Hepascore, SLFG, and Fibrometer were 0.95, 0.93, and 0.94, respectively, under the AUROC for severe fibrosis (P < 0.01). CONCLUSION The models containing direct serum markers have a better diagnostic value than those not containing direct serum markers.
Cell-to-cell transmission of human immunodeficiency virus type 1 in the presence of azidothymidine and neutralizing antibody

Very few peripheral blood lymphocytes of seropositive individuals are presumably actively infected with human immunodeficiency virus type 1 (HIV-1). During coculture of lymphocytes of a seropositive individual with mitogen-stimulated normal peripheral blood lymphocytes, the number of infected cells becomes amplified such that detectable HIV-1 is produced. We report here that in addition to transmission by extracellular virus, cell-to-cell transmission is responsible for spreading HIV-1 infection from infected to uninfected cells. Azidothymidine and virus-neutralizing antibody had no effect on cell-to-cell transmission of HIV-1. Monoclonal antibodies to the CD4 receptor, but not to the CD3 receptor, prevented cell-to-cell transmission, which suggests that CD4 receptor-mediated cell fusion is involved in cell-to-cell transmission. Spread of infection in a cell-to-cell manner may be important in development of drug therapies for HIV-1 infection.
Frequency and risk factors of recurrent pain during refeeding in patients with acute pancreatitis: a multivariate multicentre prospective study of 116 patients.

BACKGROUND/AIMS: The period of refeeding in patients with acute pancreatitis is critical because they may have pain relapse. A multicentre, multidimensional, prospective study was performed to assess the frequency and the risk factors of pain relapse in these patients. METHODS: Patients were included if they had acute pancreatitis severe enough to stop oral feeding for more than 48 hours. Clinical, biochemical, radiological, and therapeutic data were prospectively recorded and analysed by unidimensional and multidimensional analysis. The moment to refeed patients was chosen by the clinician but the diet was the same in all centres. RESULTS: A total of 116 patients were included with a Ranson's bioclinical score > or = 3 in 35% and a Balthazar's CT score > or = D in 42%. The cause of acute pancreatitis was biliary in 47% and alcohol misuse in 31%. During the oral refeeding period, 21% of the patients had pain relapse. This occurred on days 1 and 2 in 50% of patients. The duration of the painful period was longer in patients who relapsed than in others (p < 0.002). Pain relapse occurred in 39% of patients with a serum lipase concentration > 3x the upper limit of the normal range the day before refeeding and in 16% of other patients (p < 0.03). Patients with higher Balthazar's CT scores had pain relapse more often than the others (p < 0.002). None of the therapeutic procedures significantly modified the frequency of pain relapse. Using multidimensional analysis, Balathazar's CT score, period of pain, and serum lipase concentration the day before refeeding were independently associated with an increased risk of pain relapse. At a threshold of 0.5, a logistic score had a 37% sensitivity, 95% specificity, and 83% accuracy to predict pain relapse. Pain relapse nearly doubled total hospital stay and hospital stay after the first attempt at oral refeeding. CONCLUSION: Pain relapse occurred in one fifth of the patients with acute pancreatitis during oral refeeding and was more common in patients with necrotic pancreatitis and with longer periods of pain. The results of this study can be used to predict high risk patients and are a first step in the prevention of pain relapse.
Utility of diagnostic tests in the follow‐up of egg‐allergic children

Background Better knowledge of the accuracy of a skin prick test (SPT) and specific IgE (sIgE) levels to egg allergens would help to identify persistent egg‐allergic children, avoiding unnecessary risky challenges. This study was designed to assess the accuracy of a SPT and sIgE levels to egg allergens in order to determine persistent egg allergy in IgE‐mediated allergic children after an egg‐free diet.
Determinants of tumor response and survival with erlotinib in patients with non--small-cell lung cancer.

PURPOSE Erlotinib is a highly specific epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor. This phase II study of erlotinib in patients with HER1/EGFR-expressing non-small-cell lung cancer previously treated with platinum-based chemotherapy evaluated tumor response, survival, and symptom improvement. PATIENTS AND METHODS Fifty-seven patients received an oral, continuous daily dose of 150 mg of erlotinib. Assessments of objective response used WHO and Response Evaluation Criteria in Solid Tumors criteria. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30, supplemented with a lung cancer module, Quality of Life Questionnaire LC13, was used to measure health-related quality of life. Additional analyses were performed to identify predictors of response and survival. RESULTS The objective response rate was 12.3% (95% CI, 5.1% to 23.7%). Responses were observed regardless of type or number of prior chemotherapy regimens. Median survival time was 8.4 months (95% CI, 4.8 to 13.9 months), and the 1-year survival rate was 40% (95% CI, 28% to 54%). Erlotinib therapy was associated with tumor-related symptom improvement. The drug was well tolerated; drug-related cutaneous rash and diarrhea were observed in 75% and 56% of patients, respectively. One patient experienced toxicity consisting of severe grade 3 rash and diarrhea. Time since diagnosis and good performance status were significant predictors of survival in a multivariate Cox proportional hazards model, whereas HER1/EGFR staining intensity was not. Additionally, survival correlated with the occurrence and severity of rash. CONCLUSION Erlotinib was active and well tolerated in this patient population, and further clinical development is clearly warranted. Cutaneous rash seems to be a surrogate marker of clinical benefit, but this finding should be confirmed in ongoing and future studies.
Recovery of Facial Movement and Facial Synkinesis in Bell's Palsy Patients

Objective: We examined the relationship between the time course of development of facial synkinesis in patients with Bell's palsy and the severity of facial nerve damage. Study Design: Retrospective study. Setting: Tertiary referral center. Patients: Thirty-nine consecutive patients with Bell's palsy who developed synkinesis. Intervention: Diagnostic. Main Outcome Measures: Subjects were divided into groups A (electroneurographic [ENoG] value, <10%; n = 31) and B (ENoG value, ≥10%; n = 8). Development of facial synkinesis was assessed based on the appearance of synkinetic potentials from the orbicularis oris muscle on the blink reflex test. Times to appearance of facial synkinesis in groups A and B were compared. The proportion of patients who developed facial synkinesis after complete recovery of facial movement was also assessed in 14 patients whose facial movement recovered completely. Results: The mean time to maximal recovery of facial movement was significantly longer in group A than in group B (p < 0.001), whereas the duration between the appearance of facial synkinesis and the onset of facial paralysis did not differ significantly between the 2 groups (p = 0.72). The proportion of patients who developed facial synkinesis after complete recovery of facial movement was significantly greater in group B than in group A (p = 0.015). Conclusion: During the course of recovery from Bell's palsy, the patients with an ENoG value of 10% or greater have a higher risk of developing facial synkinesis after complete recovery of facial movement.
Improving the Therapeutic Ratio by Using Proton Therapy in Patients With Stage I or II Seminoma

Objectives:The goal of the present study was to evaluate possible dosimetric advantages of proton therapy (PT) compared with 3-dimensional conformal radiotherapy (3DCRT) or intensity-modulated radiotherapy (IMRT) in the treatment of patients with stage I and II seminoma. Methods:Two representative patients (1 with left-sided and 1 with right-sided seminoma) underwent treatment planning for stage I seminoma (paraaortic lymph nodes alone) with 3DCRT (PA3d), IMRT (PAimrt) double-scatter protons (PAPds), and uniform-scanning protons (PAPus) and for stage II seminoma (paraaortics lymph nodes and iliac nodes) with 3DCRT (PI3d) , IMRT (PIimrt) double-scatter protons (PIPds), and uniform-scanning protons (PIPus). The doses to the organs at risk were compared for photons and protons. Results:For stage I seminoma, PT reduced the mean dose to the stomach, ipsilateral kidney, pancreas, bowel space, small bowel, and colon compared with 3DCRT and IMRT. For stage II seminoma, PT reduced the mean dose to the same organs as in stage I seminoma with additional reductions in mean dose to the bladder and rectum compared with 3DCRT and IMRT. Uniform-scanning protons further reduced the dose to the organs at risk compared with double-scatter protons. Conclusions:PT may offer an improvement in the therapeutic ratio in patients with seminoma by reducing the dose to normal tissue. This improvement may translate into lower risks of acute gastrointestinal side effects, infertility, and secondary malignancies, which should be explored in a prospective study.