Depression and heart failure--not yet a target for therapy?

[1] Best MM, Duncan CH, Van Loon EJ, Wathen JD. Lowering of serum cholesterol by the administration of a plant sterol. Circulation 1954; 10: 201–6. [2] Heinemann T, Leiss O, von Bergmann K. Effect of low-dose sitostanol on serum cholesterol in patients with hypercholesterolemia. Atherosclerosis 1986; 61: 219–23. [3] Ling WH, Jones PJH. Minireview. Dietary phytosterols: a review of metabolism, benefits and side effects. Life Sciences 1995; 57: 195–206. [4] Ikeda I, Sugano M. Inhibition of cholesterol absorption by plant sterols for mass intervention. Curr Opin Lipidol 1998; 9: 527–31. [5] Miettinen TA, Gylling H. Regulation of cholesterol metabolism by dietary plant sterols. Curr Opin Lipidol 1999; 10: 9–14. [6] Jones PJH, Howell T, MacDougall DE, Feng JY, Parsons W. Short-term administration of Tall Oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels. Metabolism 1998; 47: 751–6. [7] Becker M, Staab D, von Bergmann K. Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol. J Pediatr 1993; 122: 292–6. [8] Denke MA. Lack of efficacy of low dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterlemia. Am J Clin Nutr 1995; 61: 392–6. [9] Heinemann T, Axtmann G, von Bergmann K. Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest 1993; 23: 827–31. [10] Field FJ, Born E, Mathur SN. Effect of micellar betasitosterol on cholesterol metabolism in CaCo-2 cells. J Lipid Res 1997; 38: 348–60. [11] Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E. Reduction of serum cholesterol with sitostanol in a mildly hypercholesterolemic population. N Engl J Med 1995; 33: 1308–12. [12] Hallikainen MA, Uusitupa MI. Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects. Am J Clin Nutr 1999; 69: 403–10. [13] Gylling H, Siimes MA, Miettinen TA. Sitostanol ester margarine in dietary treatment of children with familial hypercholesterolemia. J Lipid Res 1995; 36: 1807–12. [14] Gylling H, Miettinen TA. The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level. Atherosclerosis 1995; 117: 305–8. [15] Gylling H, Miettinen TA. Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men. J Lipid Res 1996; 37: 1776–85. [16] Gylling H, Radhakrishnan R, Miettinen TA. Reduction of serum cholesterol in post-menopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine. Circulation 1997; 16: 4226–31. [17] Gylling H, Miettinen TA. Sitostanol ester added to long-term simvastatin treatment of coronary patients with low and high basal cholesterol absorption (Abstr). Atherosclerosis 1997; 134: 157. [18] Kesaniemi YA, Enholm C, Miettinen TA. Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype. J Clin Invest 1987; 80: 578–81. [19] Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reduction of plasma total-and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1998; 52: 334–43. [20] Hendriks HFJ, Weststrate JA, van Vliet T, Meijer GW. Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1999; 53: 319–27. [21] Clayton PT, Bowron A, Mills KA, Massoud A, Casteels M, Milla PJ. Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease. Gastroenterology 1993; 105: 1806–13. [22] Gylling H, Miettinen TA. Cholesterol reduction by different plant stanol mixtures and with variable fat intake. Metabolism 1999; 48: 575–80.