Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic approach to estimate the distribution and total abundance of British mammals

Robust policy decisions regarding the protection and management of terrestrial mammals require knowledge of where species are and in what numbers. The last comprehensive review, presenting absolute estimates at a national scale, was published nearly 20 years ago and was largely based on expert opinion. We investigated and propose a systematic data driven approach combing publically available occurrence data with published density estimates to predict species distribution maps and derive total abundance figures for all terrestrial mammals inhabiting Britain. Our findings suggest that the methodology has potential; generally producing plausible predictions consistent with existing information. However, inconsistencies in the availability and recording of data impact the certainty of this output limiting its current application for policy. Restrictions on access and use of occurrence data at a local level produces “data deserts” for which models cannot compensate. This leads to gaps in spatial distribution of species and consequently underestimates abundance. For many species the limited number of geo-referenced densities hampered the extrapolation from habitat suitability to absolute abundance. Even for well-studied species, further density estimates are required. Many density estimates used were pre-1995 and therefore the derived abundance should not be considered a current estimate. To maximise a systematic approach in the future we make the following recommendations: To mitigate the attitudes of a minority of local data providers occurrence records must be submitted to national surveys such as the Mammal Society’s Mammal Tracker. Studies are required to estimate density for common species and in areas of low or no abundance. To ensure such studies can be collated and used efficiently we propose a standardised approach reporting density estimates based on the 1km resolution British National Grid, or habitat representative of the 1km square, with digital maps to accompany publications.
The Attitudes of Israeli Medical Students Toward Residency in Psychiatry

Objective: The authors analyze attitudes toward psychiatry residency of Israeli medical students in preclinical years, compared with similar U.S. data. Methods: A 23-item questionnaire was administered anonymously to 181 Israeli medical students in their preclinical years and was completed by 70% of the students present. Results: Psychiatry was ranked most attractive as far as intellectual challenge was considered and least attractive when the degree to which it draws upon all aspects of medical training was considered. Our study shows that 32.8% of the Israeli medical students in the preclinical years consider residency in psychiatry, compared to 7.7% in the U.S. and 15.9% in Australia, using the same questionnaire and methodology. Conclusions: The population of students interested in family medicine and neurology, as well as those interested in the humanities, should be the source of psychiatry residents, and their faith in the psychiatric paradigm should be strengthened.
Different effects of enoxaparin and unfractionated heparin on extrinsic blood coagulation during haemodialysis: a prospective study.

BACKGROUND Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. We studied the anticoagulant effects of unfractionated heparin (UFH) vs low-molecular-weight enoxaparin-used for thrice-weekly maintenance haemodialysis (HD)-on plasma levels of total TF and TFPI and on those of an activated coagulation marker prothrombin fragment 1+2 (PF 1+2). METHODS Twenty-five patients dialysed using a single injection of enoxaparin (at a mean dose of 0.68 mg/kg) were randomly assigned to either receive UFH administered as a mean bolus of 42.1 IU/kg and continuous infusion of 57.8 IU/kg (n=12) or to be maintained on enoxaparin (n=13), and were followed prospectively for 12 weeks. Plasma immunoreactive TF, TFPI and PF 1+2 were measured at the start and after 10 and 180 min of HD, and compared with values in 15 healthy controls. RESULTS Pre-dialysis TF, TFPI and PF 1+2 were higher than normal (all P<0.0001). TF and PF 1+2 did not change, while TFPI levels, compared with baseline, increased at each interval in enoxaparin-anticoagulated HD patients (all P<0.0001). TFPI increments correlated inversely with pre-dialysis TFPI (both P<0.0007). In patients switched to UFH, TF levels remained unchanged compared with pre-randomization values, TFPI increased at each interval of HD sessions (all P<0.035) and PF 1+2 increased pre-dialysis (P=0.015). The over-dialysis effects of UFH resembled those of enoxaparin. In contrast, baseline TFPI and its 10-min rise correlated inversely with the UFH loading dose (both P<0.040). Pre-dialysis PF 1+2 was inversely associated with TFPI increments (both P<0.034), and directly with pre-dialysis TFPI (P=0.018) and the UFH loading dose (P=0.045). CONCLUSIONS Depletion of heparin-releasable stores of TFPI is an untoward effect of repeated anticoagulation during maintenance HD therapy. The traditional UFH regimen is more prothrombotic than single enoxaparin injections, with high loading doses of UFH being involved in TFPI exhaustion and subsequent hypercoagulability.
Predicting SiC MOSFET Behavior Under Hard-Switching, Soft-Switching, and False Turn-On Conditions

Circuit-level analytical models for hard-switching, soft-switching, and <inline-formula><tex-math notation="LaTeX"> $dv/ dt$</tex-math></inline-formula>-induced false turn on of SiC MOSFETs and their experimental validation are described. The models include the high-frequency parasitic components in the circuit and enable fast, accurate simulation of the switching behavior using only datasheet parameters. To increase the accuracy of models, nonlinearities in the junction capacitances of the devices are incorporated by fitting their nonlinear curves to a simple equation. The numerical solutions of the analytical models provide more accurate prediction than an LTspice simulation with a threefold reduction in the simulation time. The analytical models are evaluated at 25 °C and 125 °C. The effect of snubber capacitors on the soft-switching waveforms is explained analytically and validated experimentally, which enables the techniques to be used to evaluate future soft-switching solutions. Finally, the <inline-formula><tex-math notation="LaTeX">$dv/ dt$</tex-math></inline-formula>-induced false turn-on conditions are predicted analytically and validated experimentally. It was observed that consideration of nonlinearities in the junction capacitances ensures accurate prediction of false turn on, and that the small shoot-through current due to false turn on can increase the switching loss by 8% for an off-state gate bias of −2 V.
Association between Obesity and Impaired Glucose Tolerance in New Providence Adolescents as Demonstrated by the HbA1c Test.

OBJECTIVE To explore the association between obesity and the development of impaired glucose tolerance (IGT) in Bahamian adolescents. METHODS Eight hundred and seventy-three adolescents were randomly selected from five high schools in New Providence. Each student's weight, height, and waist and hip circumferences were recorded to determine body mass index (BMI). Individuals with BMIs above the 84th and 95th percentiles were classified as overweight and obese, respectively. Venous blood samples were collected from each subject and haemoglobin A1c (HbA1c) levels were measured using a direct immunoassay method. The criterion established by the International Expert Committee for the diagnosis of IGT (HbA1c concentration of 6.0-6.4%) was used. An analysis of covariance was performed to evaluate the relationship between obesity and IGT, and a logistic regression analysis predicted the risk of IGT based on BMI classification. RESULTS Of the 861 adolescents who completed the study, 15.0% were classified as overweight, 15.2% as obese and 7.9% as severely obese. The overall cumulative prevalence of IGT based on HbA1c levels was 16 100 cases per 100 000 adolescents and was greater in males than in females. Higher percentages of overweight and obese students were identified as having IGT compared with their normal-weight counterparts. An analysis of covariance with post hoc analyses revealed that severely obese males and females, respectively were almost 26 (OR = 25.54, 95% CI 9.92, 65.77) or 23 (OR = 22.96,95% CI 9.81, 53.73) times more likely to develop IGT than their normal-weight counterparts (p < 0.05). CONCLUSION The data show a strong positive association between IGT and obesity among Bahamian adolescents.
Empirical Evidence on the Relation between Fiscal Credibility and Central Bank Credibility: The Brazilian case

Abstract Since the early 1990s, several countries have adopted inflation targeting (IT). However, IT may not be sufficient to ensure fiscal discipline, and governments can still pursue irresponsible fiscal policies under IT. The adoption of irresponsible policies, which lead to a weak fiscal credibility, could undermine the credibility of the central bank. In the present study, we investigate whether a correlation between fiscal credibility and central bank credibility exists. The study contributes to the literature since it presents evidence on the relation between fiscal credibility and central bank credibility. The empirical analysis uses different econometric techniques (OLS, GMM and TOBIT). The findings suggest a positive relation between fiscal credibility and central bank credibility
Clinical Implication of Heart Rate Variability in Obstructive Sleep Apnea Syndrome Patients

AbstractObstructive sleep apnea syndrome (OSAS) is a common disease with the prevalence of approximately 10% in general population, and this disease entity is considered to be highly related with the development of cerebrovascular and cardiovascular diseases. In the pathogenesis of cardiovascular disease, maintaining the homeostasis of autonomic nervous system (ANS) is critical. To evaluate the homeostasis of ANS, heart rate variability (HRV) is commonly used. The object of this study was to evaluate the homeostasis of ANS using the parameters of HRV and to elucidate the correlation between the parameters and apnea-hypopnea index (AHI). Methods:Retrospective review of 806 patients was performed and 164 patients who were diagnosed as having OSAS by in-room polysomnography and met the criteria of age, sex, and body mass index were enrolled. The calculation of HRV parameters was executed using echocardiographic data from polysomnography. Results:Between the control group (N = 81, AHI < 5) and OSAS patient group (N = 83, AHI > 15), standard deviation of NN (SDNN) intervals, SDNN index, HRV triangular index, very low frequency (VLF), low frequency (LF), 5-minute total power (TP), and low-frequency to high-frequency (LF/HF) ratio showed significant differences. In the correlation analysis between AHI and HRV parameters, only LF/HF ratio was proven to be significant. Conclusions:Elucidating the imbalance of ANS in OSAS patients was feasible by HRV and its parameters.
Prehospital point-of-care lactate following trauma: A systematic review

BACKGROUND Serum lactate serves as a surrogate marker for global tissue hypoxia following traumatic injury and has potential to guide resuscitation. Portable, handheld point-of-care monitoring devices enable lactate values to be readily available in the prehospital environment. The current review examines the utility of prehospital lactate (pLa) measurement in the management of trauma. METHODS MEDLINE and EMBASE databases were searched using predefined criteria (pLa measurement, trauma patients) until March 10, 2016. Studies were examined for lactate measurement as an intervention, prognostic indicator, and utilization in the guidance of goal-directed therapy. The Newcastle-Ottawa Scale was used to assess risk of bias, and quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation system. Data were unsuitable for meta-analysis and are presented in narrative form. RESULTS Of 2,415 articles of interest, seven met the inclusion criteria, all of which were observational studies, including 2,085 trauma patients. Lactate sampling techniques, timings, and thresholds were heterogeneous. No studies used pLa to guide intervention. Elevated pLa may be an independent prognostic marker of critical illness in trauma patients, particularly in blunt trauma. Prehospital lactate measurement may be more sensitive than systolic blood pressure in determining need for resuscitative care. Early lactate measurement may be particularly useful in the detection of occult hypoperfusion, with elevated pLa detectable within 30 minutes of injury. All current studies were assessed as being of “low” or “very low” quality and were at risk of bias. Considerable logistical barriers to pLa measurement exist. CONCLUSIONS Prehospital point-of-care lactate monitoring for trauma has been variably performed. There is a paucity of evidence relating to its use. The limited data available show feasibility and potential clinical utility, and further investigation is warranted to establish whether lactate might give meaningful guidance during prehospital triage and trauma patient resuscitation. LEVEL OF EVIDENCE Systematic review, level IV.
Controlled clinical and psychometric studies on the relation between periodontitis and depressive mood.

BACKGROUND Depressive mood is considered a risk factor for the development of periodontitis. OBJECTIVES Investigation of the relationship between periodontitis and psychopathology utilizing psychometry (both observer- and self-rating scales). METHODS Forty periodontitis patients were compared with 41 age- and sex-matched controls. The percentage of smokers was similar in both groups (30% versus 24.4%). Dental variables included probing depth, clinical attachment loss (CAL), radiographic loss of attachment, papillary bleeding index (PBI) and approximal plaque index (API). Psychometry comprised the Hamilton Depression Scale, the Zung Self-Rating Depression and Anxiety Scales, the von Zerssen Well-being and Complaint Scales, the Epworth Sleepiness Scale, the Pittsburgh Sleep Quality Index, the Quality-of-Life Index, crystallized intelligence and the Freiburg Personality Inventory (FPI). RESULTS Multifactorial analysis of variance demonstrated increased depression and anxiety scores, reduced well-being, increased somatic complaints, deteriorated quality of life and introversion in periodontitis. Partial correlation analyses between psychometric measures and dental variables revealed positive correlations of periodontal disease severity/CAL with the depression/anxiety, subjective well-being and complaints scores, and a negative correlation with quality of life. The API was negatively correlated with social orientation, and the CAL was positively correlated with somatic complaints and introversion in the FPI. CONCLUSION Our clinical-psychometric studies confirm depressive mood as a relevant pathogenetic factor for periodontitis.
Does Project Children’s University Increase Academic Self-Efficacy in 6th Graders? A Weak Experimental Design

The purpose of this study is to determine whether students’ academic self-efficacy levels increase through a 20 week of education that is based on the problem-based learning theory and transmitted in an inter-disciplinary manner in Project Children’s University. The project aimed to teach students to learn how to learn. Eventually, students will be life-long learners and gain sustainable learning skills. In order to observe the effect of Project Children’s University, academic self-efficacy levels are measured in terms of “self-efficacy in ability”, “context”, and “education quality domains”. Changes in treatment group students’ academic self-efficacy levels are modeled in growth curve modeling framework throughout three waves. Then, they are compared with those of control group students using Welch’s t test. Results have shown that the levels of academic self-efficacy throughout the research have fallen significantly for the treatment group students. In addition, the levels of self-efficacy in ability of the treatment group students were significantly higher than the levels of the control group students. On the other hand, the levels of context of the treatment group students were significantly lower than the levels of the control group students. In conclusion, Project Children’s University has failed to increase students’ academic self-efficacy levels, but entitled them to understand what academic self-efficacy really means, to socialize, to be self-confident students, and to criticize themselves more rationally.
Endoscopic therapy versus medical therapy for bleeding peptic ulcer with adherent clot: a meta-analysis.

BACKGROUND & AIMS The optimal management of bleeding peptic ulcer with adherent clot is controversial and may include endoscopic therapy or medical therapy. METHODS We searched MEDLINE, BIOSIS, EMBASE, and the Cochrane Library to identify all randomized controlled trials comparing the 2 interventions. Outcomes evaluated in the meta-analysis were recurrent bleeding, need for surgical intervention, length of hospitalization, transfusion requirement, and mortality. RESULTS Six studies were identified that included 240 patients from the United States, Hong Kong, South Korea, and Spain. Patients in the endoscopic therapy group underwent endoscopic clot removal and treatment of the underlying lesion with thermal energy, electrocoagulation, and/or injection of sclerosants. Rebleeding occurred in 5 of 61 (8.2%) patients in the endoscopic therapy group, compared with 21 of 85 (24.7%) in the medical therapy group (P = .01), for a pooled relative risk of 0.35 (95% confidence interval, 0.14-0.83; number needed to treat, 6.3). There was no difference between endoscopic therapy and medical therapy in length of hospital stay (mean, 6.8 vs 5.6 days; P = .27), transfusion requirement (mean, 3.0 vs 2.8 units of packed red blood cells; P = .75), or mortality (9.8% vs 7%; P = .54). Patients in the endoscopic therapy group were less likely to undergo surgery (pooled relative risk, 0.43; 95% confidence interval, 0.19-0.98; number needed to treat, 13.3); however, this outcome became nonsignificant when only peer-reviewed studies were considered. CONCLUSIONS Endoscopic therapy is superior to medical therapy for preventing recurrent hemorrhage in patients with bleeding peptic ulcers and adherent clots. The interventions are comparable with respect to the need for surgical intervention, length of hospital stay, transfusion requirement, and mortality.
Genetic Polymorphisms of Metastasis Suppressor Gene NME1 and Breast Cancer Survival

Purpose: Ample evidence supports an important role of tumor metastasis suppressor genes in cancer metastatic processes. We evaluated the association of genetic polymorphisms of metastasis suppressor gene NME1 with breast cancer prognosis in a follow-up study of patients with primary breast cancer and further investigated the functions of these polymorphisms. Experimental Design:NME1 genotypes were analyzed in a cohort of 1,134 breast cancer patients recruited as part of the Shanghai Breast Cancer Study who were followed for a median of 7.1 years. In vitro biochemical analyses were carried out to examine the function of NME1 gene polymorphisms. Results: Single nucleotide polymorphisms (SNP) in the promoter region of the NME1 gene were found to be associated with breast cancer prognosis. Patients carrying the C allele in rs16949649 were associated with higher breast cancer–specific mortality [hazard ratio (HR), 1.4; 95% confidence interval (95% CI), 1.1-1.9] compared with those carrying the wild-type allele, and the association was more evident in patients with an early-stage cancer (HR, 1.7; 95% CI, 1.2-2.5). SNP rs2302254 was also associated with breast cancer prognosis, and the association was statistically significant for the risk of breast cancer relapse, metastasis, and death (HR, 1.3; 95% CI, 1.0-1.6). In vitro biochemical analyses showed that minor alleles in rs2302254 and rs3760468, which is in strong linkage disequilibrium with rs16949646, altered nuclear proteins binding capacity and reduced NME1 promoter activity, supporting the results from an association study of these SNPs with breast cancer survival. Conclusion: Promoter polymorphisms in the NME1 gene may alter its expression and influence breast cancer survival.
Prolonged repeated-sprint ability is related to arterial O2 desaturation in men.

UNLABELLED The ability to repeatedly generate maximum power output is usually accompanied by neuromuscular adjustments. PURPOSE This study aimed to explore the occurrence of arterial O2 desaturation during prolonged repeated-sprint ability (RSA) testing and its relationship to neuromuscular activity, as evidenced by changes in surface integrated electromyogram (iEMG). METHODS Fifteen, national-level soccer players performed twenty 5-s cycle sprints (25 s of rest). Mechanical work and surface iEMG of the vastus lateralis (VL) and rectus femoris (RF) of the dominant lower limb were recorded for every sprint. Arterial O2 saturation (SpO2) was estimated via pulse oximetry and rating of perceived exertion (RPE) recorded immediately after every sprint. RESULTS Over the sprints, mechanical work (23.5%), iEMG (VL: 14.2%, RF: 16.4%) and SpO2 (3.5%) decreased, and RPE progressed to 19 (all P < .05). There was a strong linear relationship (R2 = .83, P < .05) between the changes in mechanical output and iEMG during the sprints. More importantly, changes in SpO2 accompanied changes in mechanical work, iEMG and RPE (R2 = .68, R2 = .64, R2 = .62, P < .05, respectively). CONCLUSION The study suggests that in a homogenous group of athletes a progressive arterial O2 desaturation develops during a prolonged RSA test, which may contribute toward performance regulation via an effect on sense of effort and neuromuscular activity.
The clinical impact of nucleic acid amplification tests on the diagnosis and management of tuberculosis in a British hospital

Background: Nucleic acid amplification tests (NAAT) based on PCR provide rapid identification of Mycobacterium tuberculosis and the detection of rifampicin resistance. Indications for their use in clinical samples are now included in British tuberculosis guidelines. Methods: A retrospective audit of patients with suspected mycobacterial infection in a Liverpool hospital between 2002 and 2006. Documentation of the impact of NAAT usage in acid fast bacillus (AFB) microscopy positive samples on clinical practice and the influence of a multidisciplinary group on their appropriate use, compared with British guidelines. Results: Mycobacteria were seen or isolated from 282 patients and identified as M tuberculosis in 181 (64%). NAAT were indicated in 87/123 AFB positive samples and performed in 51 (59%). M tuberculosis was confirmed or excluded by this method in 86% of tested samples within 2 weeks, compared with 7% identified using standard methods. The appropriate use of NAAT increased significantly over the study period. The NAAT result had a clinical impact in 20/51 (39%) tested patients. Culture results suggest the potential for a direct clinical impact in 8/36 (22%) patients in which it was indicated but not sent and 5/36 (14%) patients for whom it was not indicated. Patients managed by the multidisciplinary group had a higher rate of HIV testing and appropriate use of NAAT. Conclusions: There were significant clinical benefits from the use of nucleic acid amplification tests in this low prevalence setting. Our data suggest that there would be additional benefit from their use with all AFB smear positive clinical samples.