Miracle-dz/UniFAR-FTUs huggingface dataset:
Noise-controlled relaxation oscillations in ratio-dependent predator – prey models

A class of (N+1)-species ratio-dependent predator–prey stochastic mod els, which consists of one predator population andN prey populations (or N subpopulations of a prey metapopulation), is considered. T he influence of a fluctuating environment on the carrying capacities of pr ey populations is modeled as a dichotomous noise. The study is a follow-up of a previous investigation of the above class of models subjected to a colored-noise with low intensity [Physical Review E74, 021101 (2006)]. Relying, in case the growth rates of prey an d predator are widely different, on the mean-field approach, the self-consistency equ ations for prey-populations mean abundance and predator-population abundance are derived. In some region of system parameters, the variations of noise amplitude or correlation time can cause transitions of the mean fie ld from a globally asymptotically stable equilibrium to the stable limit cycle as well as in the opposite direction. T he conditions for the occurrence of such a phenomenon are found and illustrated by a phase diagram. Key-words: Stochastic dynamics, predator–prey models, functional re sponse, ratio-dependent, dichotomous noise, limit cycle, slow-fast cycles, noise-induced transitions .
Activation of the kallikrein-kinin system in hemodialysis: role of membrane electronegativity, blood dilution, and pH.

BACKGROUND The kallikrein-kinin system activation by contact with a negatively charged surface has been promulgated to be responsible for hypersensitivity reactions. However, to explain the low frequency and heterogeneity of hypersensitivity reactions, we hypothesized that not only the electronegativity of the membrane, but also other physicochemical parameters could influence the activation of the contact phase system of plasma assessed by the measurement of kallikrein activity and bradykinin concentration. METHODS Plasma kallikrein activity using chromogenic substrate (S2302) and plasma bradykinin concentration (enzyme immuno assay) were measured during the perfusion of human plasma (2.5 ml/min) through minidialyzers mounted with six different membranes [polyacrylonitrile (PAN) from Asahi (PANDX) and from Hospal (AN69), polymethylmethacrylate (PMMA) from Toray, cellulose triacetate (CT) from Baxter, cuprophane (CUP) from Akzo and polysulfone (PS) from Fresenius]. RESULTS A direct relationship was shown between the electronegativity of the membrane assessed by its zeta potential and the activation of plasma during the first five minutes of plasma circulation. With the AN69 membrane, the detection of a kallikrein activity in diluted plasma but not in undiluted samples confirmed the importance of a protease-antiprotease imbalance leading to bradykinin release during the first five minutes of dialysis. With PAN membranes, the use of citrated versus heparinized plasma and the use of various rinsing solutions clearly show a dramatic effect of pH on the kallikrein activity and the bradykinin concentration measured in plasma. Finally, increasing the zeta potential of the membrane leads to a significant increase of plasma kallikrein activity and bradykinin concentration. CONCLUSIONS Our in vitro experimental approach evidences the importance of the control of these physicochemical factors to decrease the activation of the contact system.
On the absolute stability approach to quantized feedback control: Further insight

By exploring some geometric properties of the logarithmic quantizer and using the fact that the logarithmic quantizer is sector bounded and nondecreasing, this paper presents a new approach to the stability analysis of quantized feedback control systems. Our method is based on Tsypkin-type Lyapunov functions that have been widely used in absolute stability analysis problems. The results are expressed in linear matrix inequalities (LMIs) and are valid for both single-input and multiple-input discrete-time linear systems with a logarithmic quantizer. Theoretical analysis shows that the results in this paper are generally less conservative than those in the quadratic framework.
Evaluation of Direct Detection of Mycobacterium tuberculosis Rifampin Resistance by a Nitrate Reductase Assay Applied to Sputum Samples in Cotonou, Benin

ABSTRACT The aim of this study was to evaluate a nitrate reductase assay (NRA) performed on smear-positive sputa for the direct detection of rifampin resistance in Mycobacterium tuberculosis. A total of 213 smear-positive sputa with a positivity score of 1+ or more (>1 acid-fast bacillus per field by fluorescence microscopy) were used in the study. The samples were decontaminated using the modified Petroff method, and portions of the resulting suspension were used to perform the NRA. The NRA results were compared with the reference indirect proportion method for 177 specimens for which comparable results were available. NRA results were obtained at day 10 for 15 specimens (9%), results for 88 specimens (50%) were obtained at day 14, results for 66 specimens (37%) were obtained at day 18, and results for the remaining 8 specimens (4%) were obtained at day 28. Thus, 96% of NRA results were obtained in 18 days. Of the 177 specimens, there was only one discrepancy (susceptible according to the NRA and resistant according to the indirect proportion method). NRA is simple to perform and provides a rapid, accurate, and cost-effective means for the detection of rifampin resistance in M. tuberculosis isolates.
Cytological and molecular characterization of intertribal hybrids between the geophytes Anemone coronaria L. and Ranunculus asiaticus L. (Ranunculaceae)

Anemone coronaria L. and Ranunculus asiaticus L. both belong to the Ranunculaceae, a large plant family with many ornamentals of horticultural importance. There are considerable differences between these species leaves, flower morphology and flower colour therefore intergeneric crosses between the species might result in new interesting hybrids. Crosses between Anemone coronaria L. and Ranunculus asiaticus L. were performed and the F1 progeny was examined. In this study, the F1 hybrid generation was investigated at morphological, molecular and cytogenetic levels. More than 85% of the F1 plants had very similar flowers to the maternal plants and although seeming to have a limited paternal contribution, AFLP analyses confirmed the partial hybrid character of the F1 plants. GISH experiments revealed that the F1 plants were mixoploids (plants composed of cells with different chromosome numbers) or showed many chromosome rearrangements.
The development of a quantitative scoring system to predict whether a large-to-massive rotator cuff tear can be arthroscopically repaired.

AIMS The aim of the study was to develop a quantitative scoring system to predict whether a large-to-massive rotator cuff tear was arthroscopically reparable prior to surgery. PATIENTS AND METHODS We conducted a retrospective review of the pre-operative MR imaging and surgical records of 87 patients (87 shoulders) who underwent arthroscopic repair of a large-to-massive rotator cuff tear. Patients were divided into two groups, based on the surgical outcome of the repair. Of the 87 patients, 53 underwent complete repair (Group I) and 34 an incomplete repair (Group II). Pre-operative MR images were reviewed to quantify several variables. Between-group differences were evaluated and multiple logistic regression analysis was used to calculate the predictive value of significant variables. The reparability index (RI) was constructed using the odds ratios of significant variables and a receiver operating characteristic curve analysis performed to identify the optimal RI cutoff to differentiate between the two groups. RESULTS The following variables were identified as independent predictors of arthroscopic reparability: the size of the defect with medial-lateral diameter (cutoff, 4.2 cm) and anterior-posterior diameter (cutoff, 3.7cm); Patte's grade of muscle atrophy (cutoff, grade 3) and Goutallier grade of fatty degeneration (cutoff, grade 3). An RI cutoff value of 2.5 provided the highest differentiation between groups I and II, with an area under the curve of 0.964, and a sensitivity of 73.5% and specificity of 96.2%. CONCLUSION The RI developed in our study may prove to be an efficient clinical scoring system to predict whether a large-to-massive rotator cuff tear is arthroscopically reparable. Cite this article: Bone Joint J 2016;98-B:1656-61.
Food Intake Detection Using Ultrasonic Doppler Sonar

Reliable, user-friendly and convenient sensing is highly desirable when the continuous monitoring of food intake is necessary. In this paper, food intake monitoring was during the processes of chewing and swallowing. Acoustic Doppler sonar (ADS) detected chewing and swallowing events that were non-contact and free from acoustic interference. When a 40 kHz ultrasonic beam was focused on the lower jaw and neck, movements of the chin and neck cause Doppler frequency shifts and an amplitude envelope modulation of ultrasonic signals. Hence, it was possible to detect chewing and swallowing events using Doppler frequency shifts in the received ultrasound signals. To prevent suspicious chew events caused by talking from being recognized as food intake events, the log-filter bank energy of the voice band was also taken into consideration. Automatic detection of chewing and swallowing events was achieved via an artificial neural network. The experimental results showed that the proposed ADS-based food intake detection method yielded promising results with maximum recognition rates of 91.4% and 78.4% for chewing and swallowing, respectively. As a result, it was confirmed that the proposed food intake detection method using ultrasonic Doppler yielded high rates of recognition without discomfort to the user from continuous skin contact.
Apigenin blocks induction of vascular endothelial growth factor mRNA and protein in progestin-treated human breast cancer cells

Objective: The results of recent clinical trials indicate that hormone therapy with estrogen and progestin is associated with higher risk of breast cancer in postmenopausal women than treatment with estrogen alone or placebo. This observation is consistent with studies showing that progestins stimulate the expression of vascular endothelial growth factor (VEGF), which in turn stimulates angiogenesis. The objective of this study was to examine whether apigenin, a natural flavone, inhibits the progestin-dependent induction of VEGF in human breast cancer cells. Methods: T47-D human breast cancer cells were treated with medroxyprogesterone acetate (MPA; 10 nM) or other synthetic progestins in the presence or absence of antiprogestin RU-486 and variable doses of apigenin (1-100 &mgr;M). BT-474 cells were also treated with MPA ± 100 &mgr;M apigenin. Secreted VEGF was quantified by enzyme-linked immunosorbent assay, and total cellular VEGF mRNA was quantified by reverse transcriptase polymerase chain reaction. The expression of VEGF receptor-1 (flt), VEGF receptor-2 (flk), progesterone receptor, and estrogen receptor-&agr; was also quantified by Western blot analysis and/or reverse transcriptase polymerase chain reaction. Results: Apigenin (50 or 100 &mgr;M) prevented progestin-dependent induction of both VEGF mRNA and protein and reduced progesterone receptor levels in T47-D cells. Apigenin also blocked MPA-dependent secretion of VEGF from BT-474 cells. mRNA levels of progesterone and estrogen receptor-&agr; were unaffected by apigenin, which did exert somewhat suppressive, although complex, effects on VEGF receptor expression in MPA-treated T47-D cells. Conclusions: Apigenin blocks progestin-dependent induction of VEGF mRNA and protein and broadly inhibits the ability of progestins to alter the expression of other components of the angiogenesis pathway, including progesterone receptor and VEGF receptors, in human breast cancer cells. Further studies are warranted to explore the potential of apigenin as a chemopreventive agent in postmenopausal women exposed to oral progestins.
Increasing Access to Prenatal Care: An Evaluation of Minority Health Coalitions' Early Pregnancy Project

Early prenatal care utilization is a problem for racial and ethnic minority women in Indiana. Minority health coalitions in Indiana developed early pregnancy care coordination projects to address this need. To evaluate project outcomes, birth certificates of infants born to project mothers were matched with birth certificates of infants whose mothers did not receive care coordination. Results showed that project mothers were significantly more likely to start prenatal care earlier, had better prenatal care utilization as measured by the Kessner Index (Kessner, Singer, Kalk, & Schlesinger, 1973), and had better adequacy of care as measured by the APNCU Index (Kotelchuck, 1994) than the noncare-coordinated mothers. Although the project was successful in meeting its primary objective, specific recommendations are made for community health nurses to partner with the coalitions in improving the content of prenatal care, decreasing sociocultural barriers to care, and assisting in the evaluation of outcomes of future projects.
Serum interleukin‐6 associated with hepatocellular carcinoma risk: A nested case–control study

Inflammatory markers have been associated with increased risk of several cancers, including colon, lung, breast and liver, but the evidence is inconsistent. We conducted a nested case–control study in the longitudinal cohort of atomic‐bomb survivors. The study included 224 hepatocellular carcinoma (HCC) cases and 644 controls individually matched to cases on gender, age, city and time and method of serum storage, and countermatched on radiation dose. We measured C‐reactive protein (CRP) and interleukin (IL)‐6 using stored sera obtained within 6 years before HCC diagnosis from 188 HCC cases and 605 controls with adequate volumes of donated blood. Analyses with adjustment for hepatitis virus infection, alcohol consumption, smoking habit, body mass index (BMI) and radiation dose showed that relative risk (RR) of HCC [95% confidence interval (CI)] in the highest tertile of CRP levels was 1.94 (0.72–5.51) compared to the lowest tertile (p = 0.20). RR of HCC (95% CI) in the highest tertile of IL‐6 levels was 5.12 (1.54–20.1) compared to the lowest tertile (p = 0.007). Among subjects with BMI > 25.0 kg/m2, a stronger association was found between a 1‐standard deviation (SD) increase in log IL‐6 and HCC risk compared to subjects in the middle quintile of BMI (21.3–22.9 kg/m2), resulting in adjusted RR (95% CI) of 3.09 (1.78–5.81; p = 0.015). The results indicate that higher serum levels of IL‐6 are associated with increased HCC risk, independently of hepatitis virus infection, lifestyle‐related factors and radiation exposure. The association is especially pronounced among subjects with obesity.
The pulmonary vasculature in a neonatal porcine model with increased pulmonary blood flow and pressure

Introduction: Hypertension and hyperperfusion of the pulmonary vascular bed in the setting of congenital cardiac malformations may lead to progressive pulmonary vascular disease. To improve the understanding of the basic mechanisms of this disease, there is a need for clinically relevant animal models which reflect the disease process. Material and Results: We randomly allocated 45 newborn pigs, at the age of 48 hrs, to groups in which there was either construction of a 3 mm central aorto-pulmonary shunt, undertaken in 9, or ligation of the left pulmonary artery, achieved in 13. Controls included sham operations in 13, or no operations in 10 pigs. Follow-up was continued for three months. The interventions were compatible with survival in most pigs. The shunts resulted in an acute 85% increase in systolic pulmonary arterial pressure, and a more than twofold increase in pulmonary blood flow. By three months of age, nearly all shunts had closed spontaneously, and haemodynamics were normal. Ligation of the left pulmonary artery resulted in a normal total pulmonary blood flow, despite only the right lung being perfused, and a 33% increase in systolic pulmonary arterial pressure. These haemodynamic changes were maintained throughout the period of study. In both groups, histomorphometry revealed markedly increased muscularity of the intra-acinar pulmonary arteries. Circulating levels of endothelin were normal in the shunted animals, and elevated in those with ligation of the left pulmonary artery. Conclusion: In neonatal porcine models of pulmonary vascular disease, created by construction of 3 mm central aorto-pulmonary shunts and ligation of one pulmonary artery, we observed histopathological changes of the pulmonary vasculature similar to early hypertensive pulmonary vascular disease in humans. Elevated circulating levels of endothelin were associated with abnormal haemodynamics rather than abnormal pathology. These findings could be valuable for future studies on the pathogenesis of hypertensive pulmonary vascular disease associated with congenital cardiac malformations.
The photovoltage of rods and cones in the dark‐adapted mouse retina

• The mouse retina has become a key model for research on the function and dysfunction of the early stages of vision, but its photoreceptors have proven difficult to access with whole‐cell recording techniques. • We have optimized the mouse retinal slice preparation to the degree required for studying photoreceptors with a reasonably high yield. • We find that single photon processing in rods is considerably more efficient than previously thought, implying a more favourable transmission at the rod–rod bipolar cell synapse. • Cones were recorded much more frequently than their numeric proportion of ∼3% allowing us to obtain direct functional evidence suggestive of rod–cone coupling in the mouse. • This study opens the way for further investigations into mammalian photoreceptor function by exploiting the powerful molecular genetic approaches available in the mouse.
On a geometrization of the Chung-Lu model for complex networks

We consider a model for complex networks that was introduced by Krioukov et al. [14], where the intrinsic hierarchies of a network are mapped into the hyperbolic plane. Krioukov et al. show that this model exhibits clustering and the distribution of its degrees has a power law tail. We show that asymptotically this model locally behaves like the well-known Chung-Lu model in which two nodes are joined independently with probability proportional to the product of some pre-assigned weights whose distribution follows a power law. Using this, we further determine exactly the asymptotic distribution of the degree of an arbitrary vertex. keywords: mathematical analysis of complex networks, hyperbolic geometry, degree distribution
Ichthyosis Follicularis, Alopecia, and Photophobia Syndrome

Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is a rare genetic, oculocutaneous disorder. So far, about forty patients have been reported worldwide. This disorder results from mutations in the membrane-bound transcription factor protease site 2 gene that impairs cholesterol homeostasis and the ability to cope with endoplasmic reticulum stress. We report this rare case of IFAP with atypical presentation and it was interesting to note that alopecia in this child was confined to eyebrows; this unique presentation has not been described earlier. This rare oculocutaneous disorder requires proper documentation so that identification of its variants may be possible in the future.
Temporal onset, risk factors, and outcomes associated with stroke after coronary artery bypass grafting.

CONTEXT Stroke is a devastating and potentially preventable complication of coronary artery bypass graft (CABG) surgery. Better understanding of the timing and risk factors for stroke associated with CABG are needed. OBJECTIVES To investigate temporal trends in stroke after CABG and to identify stroke risk factors and association with longitudinal outcomes. DESIGN, SETTING, AND PATIENTS Prospective study conducted from 1982 through 2009 at a single US academic medical center among 45,432 consecutive patients (mean age, 63 [SD, 10] years) undergoing isolated primary or reoperative CABG surgery. Strokes occurring following CABG were recorded prospectively and classified as having occurred intraoperatively or postoperatively. Complications and survival after stroke were assessed in propensity-matched groups. INTERVENTION CABG performed using 4 different operative strategies (off-pump, on-pump with beating heart, on-pump with arrested heart, on-pump with hypothermic circulatory arrest). MAIN OUTCOME MEASURES Hospital complications; late survival. RESULTS Among 45,432 patients undergoing CABG surgery, 705 (1.6% [95% confidence interval {CI}, 1.4%-1.7%]) experienced a stroke. The prevalence of stroke peaked in 1988 at 2.6% (95% CI, 1.9%-3.4%), then declined at 4.69% (95% CI, 4.68%-4.70%) per year (P = .04), despite increasing patient comorbidity. Overall, 279 strokes (40%) occurred intraoperatively and 409 (58%) occurred postoperatively (timing indeterminate in 17 patients). Postoperative stroke peaked at 40 hours, decreasing to 0.055%/d (95% CI, 0.047%-0.065%) by day 6. Risk factors for both intraoperative and postoperative stroke included older age (odds ratio, 8.5 [95% CI, 3.2-22]) and variables representing arteriosclerotic burden. Intraoperative stroke rates were lowest in off-pump CABG (0.14% [95% CI, 0.029%-0.40%]) and on-pump beating-heart CABG (0% [95% CI, 0%-1.6%]), intermediate with on-pump arrested-heart CABG (0.50% [95% CI, 0.41%-0.61%]), and highest with on-pump CABG with hypothermic circulatory arrest (5.3% [95% CI, 2.0%-11%]). Patients with stroke had worse adjusted hospital outcomes, longer intensive care and postoperative stays, and worse downstream survival (mean, 11 [SD, 8.6] years). CONCLUSION Among patients undergoing CABG surgery at a single center over the past 30 years, the occurrence of stroke declined despite an increasing patient risk profile, and more than half of strokes occurred postoperatively rather than intraoperatively.
Impact of low vision rehabilitation on functional vision performance of children with visual impairment

Purpose: To evaluate the impact of low vision rehabilitation on functional vision of children with visual impairment. Materials and Methods: The LV Prasad–Functional Vision Questionnaire, designed specifically to measure functional performance of visually impaired children of developing countries, was used to assess the level of difficulty in performing various tasks pre and post visual rehabilitation in children with documented visual impairment. Chi-square test was used to assess the impact of rehabilitation intervention on functional vision performance; a P < 0.05 was considered significant. Results: LogMAR visual acuity prior to the introduction of low vision devices (LVDs) was 0.90 ± 0.05 for distance and for near it was 0.61 ± 0.05. After the intervention, the acuities improved significantly for distance (0.2 ± 0.27; P < 0.0001) and near (0.42 ± 0.17; P = 0.001). The most common reported difficulties were related to their academic activities like copying from the blackboard (80%), reading textbook at arm's length (77.2%), and writing along a straight line (77.2%). Absolute raw score of disability pre-LVD was 15.05 which improved to 7.58 post-LVD. An improvement in functional vision post visual rehabilitation was especially found in those activities related to their studying lifestyle like copying from the blackboard (P < 0.0001), reading textbook at arm's length (P < 0.0001), and writing along a straight line (P = 0.003). Conclusions: In our study group, there was a significant improvement in functional vision post visual rehabilitation, especially with those activities which are related to their academic output. It is important for these children to have an early visual rehabilitation to decrease the impairment associated with these decreased visual output and to enhance their learning abilities.