Miracle-dz/UniFAR-FTUs huggingface dataset:
First Report of Geniospasm in a Five-Generation Brazilian Family: Clinical Features, Electromyography Findings and Botulinum Toxin Treatment

Geniospasm is a rare movement disorder characterized by spontaneous, involuntary, irregular trembling of the chin and the lower lip with accompanying involuntary contractions of the mentalis muscle. It is thought to be an autosomal-dominant inherited condition with high penetrance, which typically manifests in early life and is triggered or exacerbated by stress. When present in adults, the paroxysmal, rhythmic up-and-down movements of the lower face can lead to distress, social embarrassment and sleep impairment. It must be differentiated from other conditions, such as tic, facial myokymia and jaw tremor. In this paper, we report the first cases of geniospasm in a five-generation Brazilian family. We describe its genealogy and clinical features, the findings of electromyography testing, and the successful treatment of four living members of three generations using botulinum toxin injections. A further study amongst surviving members of the family is planned in order to evaluate genetic mutations underlying geniospasm by genomic analysis using exome sequencing.
Typhoid ileal perforation in a semi-urban tertiary health institution in north-eastern Nigeria

Introduction: Typhoid ileal perforation is a very serious complication of typhoid fever and remains a significant surgical problem in developing countries like Nigeria, where it is associated with higher mortality and morbidity, due to lack of adequate clean drinking water, poor sanitation and lack of access to health facilities in remote areas and delays in hospital presentation. Materials and methods: This was a retrospective study; all patients treated for typhoid ileal perforation at the centre in the period from January to December 2016 were included. Results: There were 22 (59.5%) males and 15 (40.5%) females, with a male to female ratio of 1.5: 1. The ages ranged from 5 to 49 years with mean of 16.5± 9.2 years. The month of October recorded the highest cases of typhoid ileal perforation. Abdominal pain, anorexia, fever and abdominal swelling were the most common symptoms reported by the subjects. The number of ileal perforations was from 1 to 7 with mean of 2.0 ± 1.3; however, the majority had a single perforation. In addition, excision and simple closure was the most common surgery performed in these cases. Operation site infection was the most common complication in this study. Furthermore, the majority of cases were successfully discharged while eight deaths were recorded. Conclusion: Typhoid ileal perforation was most common among males; abdominal pain, swelling and fever were common findings; single site perforation was the most common intra-operative findings and excision and simple closure was the most common operative procedure. Therefore early presentation, adequate resuscitation and lower number of ileal perforations are associated with better prognosis.
Toward a “Critical Mass” Theory of Interactive Media

This article proposes a “critical mass” explanation for the diffusion of interactive media, such as telephone, paper mail systems, electronic mail, voice messaging, or computer conferencing, within communities. Interactive media have two characteristics not shared by many other innovations. First, widespread usage creates universal access, a public good that individuals cannot be prevented from enjoying even if they have not contributed to it. Second, use of interactive media entails reciprocal interdependence, in which earlier users are influenced by later users as well as vice versa. Consequently, interactive media are extremely vulnerable to start-up problems and discontinuance. Traditional explanations of diffusion of innovations do not accommodate these two properties of interactive media. The influence of these two properties on the probability and extent of interactive media diffusion within communities is the focus of the critical mass theory developed in this article.
Later Aegean Bronze Swords

In an earlier article' I attempted to sketch the origins, and the range in time and space, of the first Aegean swords. These origins led back to Asia in the later third and early second millennium, on the one hand, and to a native Aegean invention of the Middle Minoan period, on the other. The result of this fusion was the A type sword of Crete and the Greek mainland; a weapon of unsurpassed size and considerable magnificence; also a less splendid but potentially more serviceable weapon, the B type sword concentrated in the Argolid. These were the two swords in the hands of the
Nebulized Magnesium Sulfate Versus Nebulized Salbutamol in AcuteBronchial Asthma: A Clinical Trial

1. Mangat HS, 2. D'Souza GA, 3. Jacob MS (1998) Eur Respir J. 12:341–344. [OpenUrl][1][Abstract][2] #### Purpose of the Study This study investigated the efficacy of nebulized magnesium sulfate as a bronchodilator in acute asthma as compared with nebulized salbutamol. ##### Study Population A total of 33 patients, 12–60 years of age, with a known history of asthma participated in the study. ##### Methods This was a randomized, double-blind, placebo-controlled trial. All subjects received 100 mg of intravenous hydrocortisone and were then randomized to receive 2.5 mg of salbutamol every 20 minutes for four consecutive doses, or 95 mg of 3.2% solution of magnesium sulfate also 20 minutes apart for four doses. The outcome measures included improvements in … [1]: {openurl}? query=rft.jtitle%253DEuropean%2BRespiratory%2BJournal%26rft.stitle%253DEur%2BRespir%2BJ%26rft.issn%253D0903-1936%26rft.aulast%253DMangat%26rft.auinit1%253DH. %26rft.volume%253D12%26rft.issue%253D2%26rft.spage%253D341%26rft.epage%253D344%26rft.atitle%253DNebulized%2Bmagnesium%2Bsulphate%2Bversus%2Bnebulized%2Bsalbutamol%2Bin%2Bacute%2Bbronchial%2Basthma%253A%2Ba%2Bclinical%2Btrial%26rft_id%253Dinfo%253Adoi%252F10.1183%252F09031936.98. 12020341%26rft_id%253Dinfo%253Apmid%252F9727782%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink? linkType=ABST&journalCode=erj&resid=12/2/341&atom=%2Fpediatrics%2F104%2FSupplement_2%2F395.1. atom
Applying academagogy : the transference of an organised heuristic teaching approach to the digital realm

Much has been written about transferring class materials and teaching techniques to digital platforms, but less has been written about applying heuristic organizing constructs in the same manner. With the transformation of learning ecologies over the past decades as well as requirements to adjust to constantly shifting digital tools and environments, the challenges for learning facilitators are to readily adapt and change, as well as to engage a changing learner demographic. However, most importantly is to engage most effectively with learners in these online environments. This article reviews the existing literature in the heuristic construct of academagogy [1] and applies a case study methodology to discussion of the first application of academagogy to the online delivery of an undergraduate design unit. Through a focus on effective teaching and learning techniques, the transfer from face-to-face (f2f) to the digital realm is explored through four main focal points: Tools for teaching, teaching and learning, communicating with students, and effective teaching methods. These four focal points are then used to discuss ways to meet the challenges of teaching online including how they create new dimensions in teaching practice and how the digital experience changes learning experiences. The article concludes with reflection and consolidation of the similarities and differences between the face-to-face and digital deliveries, and by suggesting changes to the academagogic heuristic to enable its use more easily in a digital space.
Inpatient elderly care: reducing re-admission rates

In our hospital, when demand for medical beds overwhelms capacity, patients are often ‘out-lied’ into other specialties beds to free up capacity. An observational study compared outcomes of patients admitted into an elderly care ward and outlier beds in our hospital over 14 days. Six weeks after completion of the initial study, inpatient geriatric services were expanded, and some medical outlier beds were incorporated into a new ward—the study was repeated on this new ward. 38, 26, and 35 patients with a mean age of 79, 85 and 80 years were admitted to the medical ward, outlier beds, and new medical ward respectively. Mean number of medications, comorbidities, female-to-male ratio, destination of discharge, and mortality was similar in all three cohorts. Mean length of stay was 23 days, 42 days, and 24 days. Three month re-admission rates were 25%, 50%, and 13%, respectively on the established medical ward, outlier beds, and new medical ward. The length of stay and re-admission rates for elderly patients .
Die Psychosoziale situation der Patienten mit Endogenem Ekzem

The present study was performed to investigate whether patients with atopic dermatitis differ as a group from controls on psychological measures of mood and personality or whether psychologically deviant and normal patient subgroups can be distinguished. Furthermore, we were interested in what clinical characteristics might co-vary with psychological disability in patients with atopic dermatitis
Molecular and Functional Evidence of Alzheimer's Disease in The Eye: Experimental and Clinical Application

Background: Alzheimer’s disease (AD) is a health priority, and often has delayed diagnosis. The eye has attracted interest for effective detection of AD due to distinctive visual symptoms in early stages of the disease. Recent studies have shown proteins implicated in AD may be present in the eye and can be identified through retinal imaging. We therefore hypothesise that visual disturbances in AD may be attributed to changes in the retina of the eye, and that an ocular examination including retinal imaging has the potential to become a clinical tool for early AD diagnosis. Methods: Two major components of this investigation included (1) the Octodon degus (degus) model for sporadic AD, and (2) a clinical pilot study involving human participants. Retina from degus of various ages were studied by immunohistochemistry. Clinical ocular tests, including pupillary reflex, retinal examination, cataract assessment, and intraocular pressure, were also done in degus. In a pilot study, retinal structure (optical coherence tomography) and function (visual field and electrophysiology) were assessed in young controls, elderly controls, and dementia patients. Results: AD-associated proteins were detected at high levels in the retina of adult and agedadult degus, showing neuroinflammation and cell loss, compared to younger degus. Clinical testing showed an age-related increase in cataracts and higher intraocular pressure following pupil dilation. In human participants, dementia patients had retinal thinning in the temporal and nasal quadrants of the optic disc and in the inferior hemifield of the macula, compared to elderly controls. There was also delayed latency and diminished amplitude in electrophysiological testing of the retina in one AD patient, whose disease was the most advanced. Visual field tests did not provide reliable results. Conclusion: Findings in the degus retina provided evidence that the degus is a promising model for the investigation of AD pathology in the retina. The clinical pilot study suggested that retinal examination: (1) requires minimal cognitive input; (2) is easy to perform in the clinic; (3) has potential to become a clinical diagnostic tool for AD; and (4) has provided us insight for project planning involving a larger study population.
Apprentissage collaboratif et réseaux d'investisseurs en capital-risque

L’investissement en capital risque suppose une evaluation de l’incertain. Cette derniere s’appuie sur des informations tacites et informelles qui font du lien social un vecteur important de leur obtention. La relation contractuelle devient la condition formelle d’un apprentissage collaboratif informel qui permet la creation de liens sociaux entre l’entrepreneur et ses investisseurs. Ces derniers utilisent le cadre legal des syndications comme un lieu d’echanges informels, reciproques et differes de ressources dont la logique releve de la theorie du don.
Evaluation of JAK2V617F mutation prevalence in Myeloproliferative Neoplasm by AS-RT-PCR

Karimzadeh . P 1 M.Sc, Ghaffari.SH 2 Ph.D, Chahardouli.B 2 M.Sc ,Zaghal.A 1 M.Sc, Einollahi.N 1 Ph.D, Mousavi.SA 2 MD , Bahar.B 2 MD , Dargahi.H 1 Ph.D, Alimoghaddam.K 2 MD, Ghavamzadeh.A 2 MD, Togheh.GR 4 MD, Nadali.F 3 Ph.D 1. School of Allied Health Sciences, Tehran University/ Medical Sciences. 2.Hematology-Oncology and BMT Research Center, Shariati Hospital, Tehran University/ Medical Sciences. 3.Pathology Department, School of Medicine, Isfahan University / Medical Sciences. 4. Hematology-Oncology Research Center, Emam khomeini Hospital, Tehran University/ Medical Sciences.
A meta analysis: the effectiveness of the use of mobile computers on the attitude and academic outcomes of k--12 students

Statistical meta analyses performed for this study included 32 primary studies conducted between 1993-2005. Two independent meta analyses were conducted regarding student attitudes and academic outcomes. The overall meta analysis mean by author was . 23, indicating that student use of mobile computers had a small and positive effect on student attitudes and academic outcomes. The consistent pattern of positive effect size results indicated that student use of mobile computers was effective in improving student attitudes and academic outcomes. The small number of samples in the independent meta analyses suggests a need for further research regarding mobile computers. The overall meta analysis had three purposes. The first purpose was to assess the effectiveness of student use of mobile computers on attitude and academic outcomes. The second purpose was to explore the effect of specific demographic and methodological characteristics on the measures of effect size. The third purpose was to suggest new directions for research and practice in conducting and evaluating statistical meta-analyses This dissertation was written as an alternative dissertation. Chapters one, two, three, and five follow a traditional format. Chapter four is comprised of three different but related potential journal articles addressing student use of mobile computers. Each potential journal article was written with advisement of a different committee member. The first is an independent statistical meta analyses of student attitudes. The second is an independent meta analysis of academic outcomes related to student use of mobile computers. The third article is a practitioner article. Submission of the articles for publication was required. Publication was not.
Read all about it: online learning facing 80% attrition rates

Try entering 'e-learning high attrition rates' into an appropriate search engine and you will not be short of hits that offer a variety of perceptions on the effectiveness of e-learning - and many that claim the attrition rate is as high as 80%. Can it be true that as many as eight out of ten people who begin an e-learning course fail to complete it? The answer is 'yes', and there is evidence that some kinds of e-learning are not very successful; however, it depends on what is meant by 'e' and what is meant by 'learning'. What follows is an attempt to explain the story behind the headline. It is a story that covers the last ten years and has all of the wonderful benefits of hindsight.
To Care for the Patient: a Theory Based Clinical Application Research

Background: The research is a theory based clinical application research with a participant orientation. Aims: The aim of the study is to describe meaning of th e concepts ‘care for’ and ‘not care for’ from the c arer’s perspective. Methodology : The critical incident method was chosen as data c ollection. The interpretation of data was made using hermeneutic text interpretation in four readi ngs. Results : To ‘care for’ means seeing the patient as a fello w human being which is understood as; to see the patient, to allow the immediately given and to thin k about the patient. To ‘not care for’ means seeing the patient as an ob ject which is understood as not listening to the pa tient and closing the eyes to the patient’s wishes. Conclusions To ‘care for’ as an aspect of caring is understood as an inner ethical attitude that includes responsibility and respect for the human being, an inner ethical attitude in the meaning of seeing you r fellow being with love and mercy. Seeing the patient as an object means that caring has been reduced to actio ns and work tasks without a deeper meaning .
Avaliação da técnica de PCR in house no diagnóstico de tuberculose pulmonar

There is scarce data regarding the usefulness of molecular tests used in parallel to classic tools for Tuberculosis (TB) diagnosis under field conditions, especially in regions with high burden of co-infection TB/HIV. We evaluated the usefulness of PCR dot-blot used in parallel to Ziehl-Neelsen staining (ZN) for pulmonary Tuberculosis (PTB) diagnosis, in a TB/HIV reference hospital. Sputum from 277 patients was tested by ZN, Culture and PCR. Performances were assessed individually, in parallel, by HIV status, history of antiTB treatment, and in different simulated TB prevalence rates. In overall PTB prevalence was 46% (128/277); in HIV seropositive (HIV): 54% (40/74); ZN had sensitivity (SE) lower in HIV than in HIV (43%vs68%;p<0.05); SE of PCR was not influenced by HIVstatus (p=0.46). ZN in parallel with PCR showed the following results: a) among all PTB suspects: SE (90%), Specificity (84%), Likelihood (LR)(5.65), and LR(0.12); b) in HIV seronegative subjetcts: SE (92%), LR(0.10); c) in non previously treated cases: SE (90%), LR (0.11);d) in TB prevalence rates(5-20%): negative PV(98-99). ZN used in parallel with PCR showed an improvement in SE, LR and negative PV. This strategy may offer a novel approach in ruling out PTB cases, especially in HIV, notpreviously treated, attended in hospitals in developing nations.
Subclinical Atrial Fibrillation – A Review of Present Knowledge

Clinical atrial fibrillation (AF) is defined by symptoms of AF and its documentation on surface electrocardiogram. It is known to be among the risk factors of ischemic stroke and systemic embolism. However, only about 15% of strokes are attributable to clinical AF. The most frequently identified risk factor is cerebrovascular disease. In 20% to 40% of cases with stroke no cause can be found, despite complete diagnostic evaluation, also known as cryptogenic stroke. In non-valvular AF, one must consider treatment with anticoagulation when CHA2DS2-VASc score is ≥ 1.
Ethanol as an antifungal treatment for paper: short-term and long-term effects

In paper conservation ethanol is used as an antifungal agent. However, information on the antifungal efficacy of this alcohol is scarce and often inconsistent. In this study, we clarify if ethanol is effective and safe to use in paper conservation in the short as well as in the long term. None of the tested ethanol concentrations (5–100%) promoted conidia germination, but rather delayed or entirely inhibited it, depending on alcohol concentration and contact time. In a simulation of an interventive treatment of samples colonized by fungi, all the tested ethanolic solutions (30, 70, and 100%) revealed antifungal activity. The best results were obtained with 70% ethanol, showing fungicidal properties on four of the five-tested fungal species (Aspergillus niger, Cladosporium cladosporioides, Penicillium chrysogenum, and Penicillium corylophilum). No deleterious effects of 70% ethanol on the tested paper were observed either in the short or in the long term.
COLLOID CARCINOMA OF THE COLON AND RECTUM

The origin and significance of the gelatinous material found in tumors designated colloid carcinoma has long been a subject of interest. Colloid has been described as a product of degeneration taking place in a tumor; it has probably been derived either from epithelial or connective tissue, or both. It is now agreed that it is secretory in origin and derived from the epithelial cells of tumors arising from any of the glandular epithelial structures. Accordingly, Broders 1 has defined colloid carcinoma as adenocarcinoma with a tendency to differentiate to the extent that a mucus-like substance is produced, and Robertson 2 affirmed that a colloid carcinoma is so-called because it is really a collection of mucus large enough to be appreciable to the eye. A distinction between mucus and colloid is no longer maintained; they are usually considered identical substances. Wells, 3 however, made such a distinction. He submitted a definite chemical composition for
Postoperative single versus multiple fractions high-dose rate iridium-192 surface mould brachytherapy for keloid treatment: a comparative study

Abstract Background and purpose In developing countries like Pakistan the cost effectiveness and patient convenience in any treatment modality is a question of major concern. The purpose of this study was two-fold; first to report our experience with a high-dose rate Iridium-192 surface mould brachytherapy of keloid scars after surgical excision, using different radiation treatment regimen and second to establish the most convenient and cost effective treatment protocol having no compromise on the treatment outcomes. Materials and methods From January 2012 to April 2015 a total 51 patients with 65 keloid lesions underwent postoperative Iridium-192 high-dose rate surface mould brachytherapy. The dose regimen used was: 8 Gy in a single fraction, 10 Gy in a single fraction, 15 Gy in three fractions and 18 Gy in three fractions. The median follow-up period was 33 months (range 15–53 months). Results The success rates were 57·2, 89·5, 85 and 89·5% for the treatment regimen of 8 Gy/F×1, 10 Gy/F×1, 5 Gy/F×3 and 6 Gy/F×3, respectively. Grade 2 or above radiation induced toxicity was not observed. Findings The results of this study show that a dose regimen of 10 Gy (biological effective dose=20 Gy) in a single fraction have comparable results with a dose regimen of 15 Gy in three fractions or 18 Gy in three fractions. 10 Gy in a single fraction is therefore the most convenient and cost effective dose regimen for the management of keloid scars in developing countries like Pakistan, while 8 Gy in a single fraction is considered suboptimal and discouraged in practice.
THE CORRELATION BETWEEN METACOGNITIVE READING STRATEGIES AND READING COMPREHENSION OF ENGLISH DEPARTMENT STUDENTS

The objectives are to find the type and frequency Global, Problem Solving, and Support reading strategies the students use during reading, to find the correlations between each three reading strategies and reading comprehension. The instruments used are a survey on metacognitive reading strategies adapted from MARSI and SILL and a reading comprehension test. The findings revealed that PROB strategies were used the most, followed by GLOB strategies, and SUPP strategies. The correlations showed that (1) a positive, moderate (at .66) correlation between GLOB and reading comprehension, (2) a positive, strong correlation (at .72) between PROB and reading comprehension, and (3) a positive, weak correlation (at .26) between SUPP and reading comprehension.