Miracle-dz/UniFAR-FTUs huggingface dataset:
The effective practitioner : the role and contribution of therapist effects in the delivery of psychological therapies

Abstract Background: Variability in human performance is a naturally occurring phenomenon and applies to practitioners. Mainstream psychotherapy research has focused on treatments rather than practitioners and has viewed variability as error within the dominant paradigm of the randomised controlled trial. Aims: To investigate variability via the role of practitioner personal qualities and their association with differential patient outcomes, their contribution to effective practice, and the extent these qualities vary with patient severity. Method: A practice-based paradigm was adopted and sampled practitioners and data within a single Improving Access to Psychological Therapies (IAPT) service. The full sample comprised 42 practitioners – psychological wellbeing practitioners, counsellors, and cognitive-behaviour therapists – who completed measures of resilience, empathy, and mindfulness as well as provided qualitative accounts of their practice. A series of seven sequential studies utilised subsamples of the responses from these 42 practitioners, which were analysed prior to yoking with their patient outcome data to determine associations with more and less effective practice. Studies comprised mixed and integrated quantitative and qualitative analyses comparing benchmarking and multilevel modelling research methods (N=37) and thematic analysis (N=6). Results: Significant variability in practitioner effectiveness was found. Practitioners’ personal aspects were associated with patient outcomes and were influenced by their professional roles, level of treatment intensity provided, and their theoretical orientation. Practitioners’ mindfulness and combined resilience and mindfulness were associated with better patient outcomes and this role increased as patient severity increased. In contrast, empathy did not differ between more and less effective practitioners, with more effective practitioners showing marginally lower levels of empathy. Conclusion: Findings suggest that more effective practitioners do differ from less effective practitioners in the personal aspects they bring to their professional practice. Findings have implications for practitioner training and routine practice. The findings are limited in their generalisability and may only apply to IAPT services.
2–Benzylidene–1–Indanone Analogues as Dual Adenosine A1/A2a Receptor Antagonists for the Potential Treatment of Neurological Conditions

Abstract Previous studies explored 2-benzylidine-1-tetralone derivatives as innovative adenosine A1 and A2A receptor antagonists for alternative non-dopaminergic treatment of Parkinson’s disease. This study’s aim is to investigate structurally related 2-benzylidene-1-indanones with substitutions on ring A and B as novel, potent and selective adenosine A1 and A2A receptor blockers. 2-Benzylidene-1-indanone derivatives were synthesised via acid catalysed aldol condensation reactions and evaluated via radioligand binding assays to ascertain structure activity relationships to govern A1 and A2A AR affinity. The results indicated that hydroxy substitution at C4 of ring A and meta (3’), or para (4’) substitution on ring B of the 2-benzylidene-1-indanone scaffold (2c) is preferred over substitution at C5 (2d) or C6 (2e) of ring A for adenosine A1 receptor activity and selectivity in the micromolar range. Furthermore, substitution at the meta (3’) position of ring B with chlorine lead to the highly potent and selective adenosine A2A receptor antagonist, compound 2 h. Compound 2c and the 2q behaved as adenosine A1 receptor antagonists in the performed GTP shift assays. In view of these findings, compounds 2c, 2 h, 2q and 2p are potent and selective adenosine A1 and A2A receptor antagonists for the potential treatment of neurological conditions.
Correlation Analysis to Identify the Effective Data in Machine Learning: Prediction of Depressive Disorder and Emotion States

Correlation analysis is an extensively used technique that identifies interesting relationships in data. These relationships help us realize the relevance of attributes with respect to the target class to be predicted. This study has exploited correlation analysis and machine learning-based approaches to identify relevant attributes in the dataset which have a significant impact on classifying a patient’s mental health status. For mental health situations, correlation analysis has been performed in Weka, which involves a dataset of depressive disorder symptoms and situations based on weather conditions, as well as emotion classification based on physiological sensor readings. Pearson’s product moment correlation and other different classification algorithms have been utilized for this analysis. The results show interesting correlations in weather attributes for bipolar patients, as well as in features extracted from physiological data for emotional states.
Data-Driven Based Approach to Aid Parkinson’s Disease Diagnosis

This article presents a machine learning methodology for diagnosing Parkinson’s disease (PD) based on the use of vertical Ground Reaction Forces (vGRFs) data collected from the gait cycle. A classification engine assigns subjects to healthy or Parkinsonian classes. The diagnosis process involves four steps: data pre-processing, feature extraction and selection, data classification and performance evaluation. The selected features are used as inputs of each classifier. Feature selection is achieved through a wrapper approach established using the random forest algorithm. The proposed methodology uses both supervised classification methods including K-nearest neighbour (K-NN), decision tree (DT), random forest (RF), Naïve Bayes (NB), support vector machine (SVM) and unsupervised classification methods such as K-means and the Gaussian mixture model (GMM). To evaluate the effectiveness of the proposed methodology, an online dataset collected within three different studies is used. This data set includes vGRF measurements collected from eight force sensors placed under each foot of the subjects. Ninety-three patients suffering from Parkinson’s disease and 72 healthy subjects participated in the experiments. The obtained performances are compared with respect to various metrics including accuracy, precision, recall and F-measure. The classification performance evaluation is performed using the leave-one-out cross validation. The results demonstrate the ability of the proposed methodology to accurately differentiate between PD subjects and healthy subjects. For the purpose of validation, the proposed methodology is also evaluated with an additional dataset including subjects with neurodegenerative diseases (Amyotrophic Lateral Sclerosis (ALS) and Huntington’s disease (HD)). The obtained results show the effectiveness of the proposed methodology to discriminate PD subjects from subjects with other neurodegenerative diseases with a relatively high accuracy.
Stratification of Poor Outcomes for Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patients Using the American Joint Committee on Cancer Eighth Edition and Brigham and Women's Hospital Staging Systems.

BACKGROUND Staging systems for cutaneous squamous cell carcinoma (CSCC) include Brigham and Women's Hospital (BWH) and American Joint Committee on Cancer staging system, eighth edition (AJCC-8). OBJECTIVE To evaluate and compare AJCC-8 and BWH staging systems for CSCC in immunosuppressed patients. MATERIALS AND METHODS A retrospective cohort study of immunosuppressed patients diagnosed with primary CSCC from 2012 to 2016. The main end point was any poor outcome (PO), which included local recurrence, nodal metastasis, and disease-specific death. RESULTS Fifty-eight immunosuppressed patients had 263 CSCCs. Fifty percent of tumors were AJCC-8 T1, 44.7% T2, and 4.8% T3. Fifty percent of tumors were BWH T1, 48.5% T2a, 1.3% T2b, and 0.4% T3. Risk of PO for AJCC-8 was 1.7%, 8.8%, and 36.4% for T1, T2, and T3, respectively (p < .01). Risk of PO for BWH was 1.8%, 9.9%, 33.3%, and 100.0% for T1, T2a, T2b, and T3, respectively (p < .01). Thirty-six percent of AJCC-8 T3/T4 tumors had POs compared with 5.1% in low T1/T2 stages (p = .002). Fifty percent of BWH T2b/T3 tumors had POs compared with 5.3% in low T1/T2a stages (p = .01). CONCLUSION AJCC-8 and BWH staging systems stratify CSCC with similar distinctiveness, homogeneity, and monotonicity for immunosuppressed patients.
WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to nonhuman primates (NHP)

Abstract Purpose: Defined animal models are needed to pursue the FDA Animal Rule for approval of medical countermeasure for radiation injuries. This study compares WAG/RijCmcr rat and nonhuman primate (NHP) models for acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE). Materials and methods: Irradiation models include total body irradiation, partial body irradiation with bone marrow sparing and whole thorax lung irradiations. Organ-specific sequelae of radiation injuries were compared using dose–response relationships. Results and conclusions: Rats and NHP manifest similar organ dysfunctions after radiation, starting with acute gastrointestinal (GI-ARS) and hematopoietic (H-ARS) syndromes followed by lung, heart and kidney toxicities. Humans also manifest these sequelae. Latencies for injury were earlier in rats than in NHP. After whole thorax lung irradiations (WTLI) up to 13 Gy, there was recovery of lung function from pneumonitis in rats. This has not been evaluated in NHP. The latency, incidence, severity and progression of radiation pneumonitis was not influenced by early multi-organ injury from ARS in rats or NHP. Rats developed more severe radiation nephropathy than NHP, and also progressed more rapidly. Dosimetry, anesthesia, environment, supportive care, euthanasia criteria etc., may account for the alterations in radiation sensitivity observed between species.
The Role of Group Norms in Evaluating Uncommon and Negative Behaviors

Children often believe that how a group is reflects how individual group members should be. We provided a strong test of this descriptive-to-prescriptive tendency by examining whether children (Ages 4 to 9) maintained the correctness of group norms even when such norms differed in their prevalence (e.g., drinking juice out of bowls instead of cups; Study 1) or in their valence (e.g., giving people punches instead of flowers; Study 2). In Study 1, disapproval toward nonconformity varied as a function of the norm’s prevalence and of participant age. In Study 2, both children and adults approved of conformity to positive norms and disapproved of conformity to negative norms (e.g., “If Glerks make babies cry, an individual Glerk should not”). Nevertheless, across studies, descriptive-to-prescriptive reasoning played a role. In Study 1, participants evaluated nonconformity to common norms as worse than conformity to uncommon norms (even though both cases involved uncommon behavior), and they evaluated nonconformity to uncommon norms as worse than conformity to common norms (even though both cases involved common behavior). In Study 2, participants evaluated nonconformity to positive norms as worse than conformity to negative norms (even though both cases involved negative behavior), and they evaluated nonconformity to negative norms as worse than conformity to positive norms (even though both cases involved positive behavior). Together, these data highlight the limits (and scope) of descriptive-to-prescriptive reasoning and suggest that when children (and adults) evaluate the appropriateness of someone’s behavior, they consider not only the behavior, but also, the norms of the group.
Radiation-induced rescue effect

Abstract Radiation-induced rescue effect (RIRE) refers to the phenomenon in which detrimental effects in targeted irradiated cells are reduced upon receiving feedback signals from partnered non-irradiated bystander cells, or from the medium previously conditioning these partnered non-irradiated bystander cells. For convenience, in the current review we define two types of RIRE: (i) Type 1 RIRE (reduced detrimental effects in targeted cells upon receiving feedback signals from bystander cells) and (ii) Type 2 RIRE (exacerbated detrimental effects in targeted cells upon receiving feedback signals from bystander cells). The two types of RIRE, as well as the associated mechanisms and chemical messengers, have been separately reviewed. The recent report on the potential effects of RIRE on the traditional colony-formation assays has also been reviewed. Finally, future priorities and directions for research into RIRE are discussed.
Utilizing Problem Based Learning in Pre-Service Teacher Education: Experiences of Prospective Teachers in Pakistan

The quintessence of learning will be figuring out how to learn and think with a specific goal to meet the demands of the 21st century. Specifically, learners ought to be prepared to work in various situations with numerous unpredictable requirements. The present experimental study depicts the experiences of prospective teachers while studying a course through Problem Based Learning. The study was conducted by using a quasiexperimental design. The lecture-cum-discussion method was followed in the control group, whereas the lessons in the treatment group were implemented according to the 7-steps of Problem-Based Learning. A purposive sample of two groups (control and experimental group) of female prospective teachers studying the course of Educational Research enrolled in Department of Education, International Islamic University Islamabad was taken for the study. The experimental group (N=30) described their experiences of learning the course through PBL in interviews. The analysis was done through coding the responses and making themes.
LESIONES PREINVASORAS DE CUELLO UTERINO: UNA VISIÓN ACTUAL

SUMMARY Each year in Chile around 1200 new cases of invasive cervical cancer are reported with 677 death by this cause (death rate: 8.4/100,000 women). The epidemiological causative relation between cervical cancer and human papilloma virus is probably the strongest in the international literature. We analyzed carefully its roll in cervical carcinogenesis and the utility of viral typing in the study and management of an abnormal cytology in the Chilean model of assistance.
Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting

The Sarcolab pilot study of 2 crewmembers, investigated before and after a 6‐mo International Space Station mission, has demonstrated the substantial muscle wasting and weakness, along with disruption of muscle's oxidative metabolism. The present work aimed at evaluating the pro/anti‐inflammatory status in the same 2 crewmembers (A, B). Blood circulating (c‐)microRNAs (miRs), c‐proteasome, c‐mitochondrial DNA, and cytokines were assessed by real‐time quantitative PCR or ELISA tests. Time series analysis was performed (i.e., before flight and after landing) at 1 and 15 d of recovery (R+1 and R+15, respectively). C‐biomarkers were compared with an age‐matched control population and with 2‐dimensional proteomic analysis of the 2 crewmembers' muscle biopsies. Striking differences were observed between the 2 crewmembers at R+1, in terms of inflamma‐miRs (c‐miRs‐21‐5p, ‐126‐3p, and ‐146a‐5p), muscle specific (myo)‐miR‐206, c‐proteasome, and IL‐6/leptin, thus making the 2 astronauts dissimilar to each other. Final recovery levels of c‐proteasome, c‐inflamma‐miRs, and c‐myo‐miR‐206 were not reverted to the baseline values in crewmember A. In both crewmembers, myo‐miR‐206 changed significantly after recovery. Muscle biopsy of astronaut A showed an impressive 80% increase of α‐1‐antitrypsin, a target of miR‐126‐3p. These results point to a strong stress response induced by spaceflight involving muscle tissue and the proinflammatory setting, where inflamma‐miRs and myo‐miR‐206 mediate the systemic recovery phase after landing. —Capri, M. , Morsiani, C. , Santoro, A. , Moriggi, M. , Conte, M. , Martucci, M. , Bellavista, E. , Fabbri, C. , Giampieri, E. , Albracht, K. , Flück, M. , Ruoss, S. , Brocea, L. , Canepari, M. , Longa, E. , Di Giulio, I. , Bottinelli, R. , Cerretelli, P., Salvioli, S. , Gelfi, C. , Franceschi, C. , Narici, M. , Rittweger, J. Recovery from 6‐month spaceflight at the International Space Station: muscle‐related stress into a proinflammatory setting. FASEB J. 33, 5168–5180 (2019). www.fasebj. org
Sexual and Relationship Satisfaction: The Role of Perceived (Non)problematic Sexual Desire Discrepancy in Gay and Heterosexual Men

Abstract Sexual desire discrepancy has been associated with sexual and relationship dissatisfaction. Nonetheless, little is known regarding the role of desire discrepancy in gay men, as main research has been systematically conducted with heterosexual couples. Also, only one study has focused on problematic sexual desire discrepancies and sexual satisfaction with lesbian women. This study sought to understand if perceived sexual desire discrepancy influences sexual and relationship satisfaction in men, and to explore differences according to sexual orientation. A total of 346 men (245 heterosexual and 101 gay) completed an online survey and answered sociodemographic questions, a specific question about sexual desire discrepancy, and completed the Global Measure of Sexual Satisfaction and the Global Measure of Relationship Satisfaction. The main findings showed differences in sexual and relationship satisfaction according to sexual desire discrepancy groups, with men who experienced no desire discrepancy being more satisfied within their relationship and sex life compared to men who experienced both problematic and nonproblematic sexual desire discrepancy. Additionally, men who experienced nonproblematic sexual desire discrepancy reported being more sexually and relationship satisfied than men who experienced problematic sexual desire discrepancy. No sexual orientation differences were found. Overall, current findings emphasize the role of (non)problematic desire discrepancy in sexual and relationship satisfaction among heterosexual and gay men.
Single-molecule imaging of the transcription factor SRF reveals prolonged chromatin-binding kinetics upon cell stimulation

Significance How transcription factors (TFs) activate transcription is a long-standing but still unsolved question. We analyzed serum response factor (SRF), a stimulus-responsive TF mediating immediate early gene (IEG) and cytoskeletal gene expression at single-molecule resolution. Cell stimulation enhanced SRF activity by increasing the number of long chromatin-associated SRF molecules in an oscillating pattern. Further, stimulation enhanced the SRF chromatin residence time, and SRF binding events segregated into three distinct residence time regimes (short, intermediate, and long bound). In summary, our single-molecule imaging study reveals highly dynamic and diverse SRF interactions with DNA. Thus, cell stimulation regulates TF activity by several interconnected mechanisms including nucleus−cytoplasm shuttling, TF phosphorylation, cofactor recruitment, and extension of chromatin residence time and enhancing chromatin-bound TF numbers. Serum response factor (SRF) mediates immediate early gene (IEG) and cytoskeletal gene expression programs in almost any cell type. So far, SRF transcriptional dynamics have not been investigated at single-molecule resolution. We provide a study of single Halo-tagged SRF molecules in fibroblasts and primary neurons. In both cell types, individual binding events of SRF molecules segregated into three chromatin residence time regimes, short, intermediate, and long binding, indicating a cell type-independent SRF property. The chromatin residence time of the long bound fraction was up to 1 min in quiescent cells and significantly increased upon stimulation. Stimulation also enhanced the long bound SRF fraction at specific timepoints (20 and 60 min) in both cell types. These peaks correlated with activation of the SRF cofactors MRTF-A and MRTF-B (myocardin-related transcription factors). Interference with signaling pathways and cofactors demonstrated modulation of SRF chromatin occupancy by actin signaling, MAP kinases, and MRTFs.
Influences of Sociosexuality and Commitment on Online Sexual Activities: The Mediating Effect of Perceptions of Infidelity

Abstract The perceived infidelity of online sexual activity (OSA) has been noted as an important factor contributing to individual differences in OSA among people in romantic relationships. We proposed that two major factors related to infidelity—sociosexuality (willingness to engage in uncommitted sexual relationships) and commitment—might be associated with engaging in OSA via the perceived infidelity of OSA among individuals in romantic relationships. OSAs were classified as viewing sexually explicit material, seeking sexual partners, cybersex, and flirting. Participants were 313 heterosexuals in romantic relationships who completed measures of OSA experience, sociosexuality, commitment, and perceptions of infidelity. The results showed that more unrestricted sociosexuality and less commitment were associated with more frequent engagement in OSAs. Moreover, perceptions of infidelity mediated these associations of sociosexuality and commitment with OSA. These findings suggest that perceived infidelity is important for understanding the mechanism underlying people’s engagement in OSA.
A 20‐year study of suicide death in a statewide autism population

Growing concern about suicide risk among individuals with autism spectrum disorder (ASD) necessitates population‐based research to determine rates in representative samples and to inform appropriate prevention efforts. This study used existing surveillance data in Utah to determine incidence of suicide among individuals with ASD over a 20‐year period, and to characterize those who died. Between 1998 and 2017, 49 individuals with ASD died by suicide. Suicide cumulative incidence rates did not significantly differ between 1998 and 2012 across the ASD and non‐ASD populations. Between 2013 and 2017, the cumulative incidence of suicide in the ASD population was 0.17%, which was significantly higher than in the non‐ASD population (0.11%; P < 0.05). During this period, this difference was driven by suicide among females with ASD; suicide risk in females with ASD was over three times higher than in females without ASD (relative risk (RR): 3.42; P < 0.01). Among the individuals with ASD who died by suicide, average age at death and manner of death did not differ significantly between males and females. Ages at death by suicide ranged from 14 to 70 years (M[SD] = 32.41[15.98]). Individuals with ASD were significantly less likely to use firearms as a method of suicide (adjusted odds ratio: 0.33; P < 0.001). Study results expand understanding of suicide risk in ASD and point to the need for additional population‐based research into suicide attempts and ideation, as well as exploration of additional risk factors. Findings also suggest a need for further study of female suicide risk in ASD. Autism Research 2019, 12: 658–666. © 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc.