Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunochemotherapy with Intensive Consolidation for Primary CNS Lymphoma: A Pilot Study and Prognostic Assessment by Diffusion-Weighted MRI

Purpose: We evaluated a novel therapy for primary central nervous system lymphoma (PCNSL) with induction immunochemotherapy with high-dose methotrexate, temozolomide, and rituximab (MT-R) followed by intensive consolidation with infusional etoposide and high-dose cytarabine (EA). In addition, we evaluated the prognostic value of the minimum apparent diffusion coefficient (ADCmin) derived from diffusion-weighted MRI (DW-MRI) in patients treated with this regimen. Experimental Design: Thirty-one patients (median age, 61 years; median Karnofsky performance score, 60) received induction with methotrexate every 14 days for 8 planned cycles. Rituximab was administered the first 6 cycles and temozolomide administered on odd-numbered cycles. Patients with responsive or stable central nervous system (CNS) disease received EA consolidation. Pretreatment DW-MRI was used to calculate the ADCmin of contrast-enhancing lesions. Results: The complete response rate for MT-R induction was 52%. At a median follow-up of 79 months, the 2-year progression-free and overall survival were 45% and 58%, respectively. For patients receiving EA consolidation, the 2-year progression-free and overall survival were 78% and 93%, respectively. EA consolidation was also effective in an additional 3 patients who presented with synchronous CNS and systemic lymphoma. Tumor ADCmin less than 384 × 10–6 mm2/s was significantly associated with shorter progression-free and overall survival. Conclusions: MT-R induction was effective and well tolerated. MT-R followed by EA consolidation yielded progression-free and overall survival outcomes comparable to regimens with chemotherapy followed by whole-brain radiotherapy consolidation but without evidence of neurotoxicity. Tumor ADCmin derived from DW-MRI provided better prognostic information for PCNSL patients treated with the MTR-EA regimen than established clinical risk scores. Clin Cancer Res; 18(4); 1146–55. ©2012 AACR.
A pediatric emergency department follow-up system: Completing the cycle of care

Background Prior to 1993, the follow-up program for our pediatric emergency department (ED) was the responsibility of the rotating senior pediatric resident. There were inherent problems with this system, as a consequence of inconsistent personnel. The residents’ revolving schedules and the fact that they were accountable to other clinical areas decreased their availability for follow-up. Also, it was difficult for the clerical staff to identify the person responsible for answering parent calls. The medical director of the ED made the decision to turn the core responsibility for the follow-up program to the nurse practitioners in addition to their direct care provider role. The nurse practitioner group is a consistent member of the treatment team who has the critical thinking skills necessary to handle the majority of issues that require follow-up. The emergency attending physicians are available for consultation whenever questions arise. Objective Review of current follow-up program of a pediatric ED and its impact on patient care, patient/parent satisfaction, and communication with community providers and specialists. Method A retrospective review of the evolution of the multi-faceted follow-up of patients from an urban pediatric ED. Results Antidotal evidence suggests that a comprehensive follow-up program increases patient satisfaction, improves communication between the ED, primary care providers, and specialists. It also decreases the workload of the attending emergency physicians, allowing them more time to focus on acute issues. In addition, the follow-up program for ED patients can decrease the medical /legal risks associated with reporting of delayed laboratory results. Conclusion The next step in further reviewing this program is the development of a satisfaction questionnaire for patient/ families and community providers to quantify their level of satisfaction with the program. A retrospective chart review of the patients who received a follow-up phone call after discharge, and the return visit rate would be another avenue to pursue to validate our antidotal information.
Analysis and Validation of a Planar High-Frequency Contactless Absolute Inductive Position Sensor

This paper presents a low cost precise and reliable inductive absolute position measurement system. It is suitable for rough industrial environments, offers a high inherent resolution (0.1%-0.01% of measurement range), can measure target position over a wide measurement range, and can potentially measure multiple target locations simultaneously. The basic position resolution is improved by adding two additional finer pitched receive channels. The sensor works on principles similar to contactless resolvers. It consists of a rectangular antenna printed circuit board and a passive LC resonant circuit. A mathematical model and the equivalent circuit of this kind of sensor are explained in detail. Such sensors suffer from transmitter to receiver coil capacitive crosstalk, which results in a phase sensitive offset. This crosstalk will be analyzed by measurements. Moreover, the mechanical transducer arrangement, the measurement setup, and the measured results will be presented.
Maternal Health and Child Mortality in Rural India

In this paper, the effect of maternal health on the under-five mortality has been examined. Third wave of micro-level National Family Health Survey 2005-06 data for rural India is used. Using various alternative measures of maternal health, the paper finds strong association between maternal health and child mortality. In particular, the effects of maternal height, weight, presence of any disease and anemia are found significant. Based on our findings, we argue that if the possible generational transfer of poor health from a mother to her child has to avoid, policies aimed at attaining the millennium development goal of reduced child mortality should be directed on improving the health of existing and future mothers.
Longitudinal evidence of crystalline lens thinning in children.

PURPOSE Most earlier studies indicated that the eye's crystalline lens grows continually throughout life, but cross-sectional results of crystalline lens thinning during childhood have been reported. The authors investigated crystalline lens thickness in childhood using cross-sectional and longitudinal data. METHODS The Orinda Longitudinal Study of Myopia is a community-based study of normal eye growth and myopia development in school-age children. During a 1-to 3-year period, A-scan ultrasonographic lens thickness measurements of 869 children 6 through 14 years of age were analyzed. RESULTS On average, between the ages of 6 and 10 years, the crystalline lens thins in its axial dimension by almost 0.2 mm. This thinning can be depicted by a cubic model. In this sample, the children with myopia had thinner crystalline lenses than the children with emmetropia of the same age. CONCLUSIONS This article provides the first longitudinal evidence that the crystalline lens thins during the period of coordinated ocular growth between the ages of 6 and 10 years. Further, it shows that lens thickness is associated with refractive error. Thinner crystalline lenses in children with myopia may result from one of two underlying mechanisms: Either the crystalline lens exhausts its ability to compensate for axial elongation after undergoing accelerated lens thinning before the onset of myopia, or the crystalline lens in the myopic eye may be thinner throughout childhood, during which it thins at a rate consistent with other refractive errors. If mechanical forces link eye growth to crystalline lens compensation, more complex, visually guided feedback loops may not be needed to explain the normal eye growth that results in emmetropization.
Plant Diversity, Production, Stability, and Susceptibility to Invasion in Restored Northern Tall Grass Prairies (United States)

This study investigated the relationship among plant diversity, production, stability, and susceptibility to invasion in restored northern tall grass prairies (United States). The experiment consisted of 50 species mixtures fertilized with N or P, at high or low levels. Results from the past 5 years were as follows: (1) aboveground biomass increased and year‐to‐year variability declined with increases in plant species and functional form richness, mostly as a result of substantial increases in minimum biomass (maximum biomass was unaffected). (2) Aboveground biomass and biomass stability increased when the species in the mixture had: (a) high relative growth rates, root density, root surface area per unit of root biomass, uptake rates of N or P per unit of root surface area, and N use efficiency and (b) low root to shoot ratio. (3) Invasion of nonseeded species declined with increases in plant species and functional form richness. (4) The results from this experiment did not provide a single specific criterion for selecting an optimal species mixture. However, if the objectives of the restoration were simply to achieve an aboveground biomass variability that is less than that of growing‐season precipitation, then the seed mixtures need to have a minimum of nine species and three functional forms.
Utilité et désirabilité d'informations normatives sur des subordonnés et des collègues de travail

Diverses etudes ont ete realisees sur la valeur d'autrui caracterise par des traits de personnalite ou une profession. Nous avons ici choisi d'etudier non plus la valeur d''une personne mais la valeur d'informations portant sur cette personne. 426 salaries, repartis en 8 groupes independants, ont ainsi indique, par 2 procedures differentes, la desirabilite et l'utilite qu'ils attribuaient a des informations referant au degre d'adhesions normatives d'un futur subordonne ou d'un futur pair. Nous observons alors, outre des resultats divergeants selon la procedure, notamment de la part des responsables d'encadrement, que la desirabilite et l'utilite constituent deux dimensions de la valeur non systematiquement liees. Nous constatons egalement que les jugements different selon le statut du futur collaborateur (subordonne ou pair) et selon la norme sur laquelle porte l'information (internalite, croyance au monde juste, allegeance).
Enriching the International Tourist Experience of Local Malaysian Cuisine and a Guarantee of a Purchase Intention

Gastronomy tourism contributes to about one-fifth of the Malaysian economy, indicating that people travel to the country are probably interested in experiencing the taste of the food. This study aims to identify the tourists’ experience as well as their purchase intention of local Malaysian food. The findings of 202 international tourists at Bukit Bintang in Kuala Lumpur highlighted both the characteristics of local Malaysian food and environmental factors as significant influences in the tourists’ willingness to purchase and to savour local food again. Their potential return visit to the country will benefit the tourism industry and the country’s foreign exchange.Keywords: Environmental Factors; Gastronomy Tourism; Malaysian Local Food, Purchase IntentioneISSN 2398-4295 © 2019. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: http://dx.doi. org/10.21834/ajbes.v4i16. 176
Informal and formal caregivers' involvement in nursing home care activities: impact of integrated care.

AIMS This paper reports a study to investigate the relationships between informal and formal care, changing relationships over time, impact of integrated care, and theoretical and methodological lessons that can be drawn from research on this topic. BACKGROUND The ratio of informal to formal care provided in nursing homes varies. In many countries the predominance of traditional, formal care is being challenged by the emergence of integrated care models in which formal and informal caregivers co-operate and co-ordinate their activities to deliver tailor-made care. This move towards integrated care is likely to result in changes in the degree and nature of involvement of formal and informal caregivers in care activities. However, very little research has investigated this. Previous research is restricted to one point in time, as opposed to focussing on the changing relationships between formal and informal caregivers over time. METHODS The quasi-experimental design encompassed a traditional care comparison setting and an experimental setting with an integrated care intervention. At three measurement points, one before the intervention in May/June 2000 and two at 6 and 14 months after the intervention, informal and formal caregivers recorded their care activities. Informal care relationships were determined by calculating contribution rates and informal/formal care ratios for 14 activities. RESULTS Integrated care did not bring about the expected major changes. There was a limited amount of substitution of formal care with informal care. There were limited changes in the extent of dual specialization, in which informal and formal caregivers perform separate activities. There was little supplementation of formal care with informal care. Furthermore, relationships changed over time, resulting in a complex pattern of linkages at the level of separate activities. CONCLUSIONS Informal caregivers contribute to many activities. The impact of integrated care on the degree and nature of involvement, however, was moderate. A possible explanation is the contextual situation for nursing home care. These findings point to the need for further research into the (changing) relationship between formal and informal carers in residential care activities and the evolution of this relationship over time.
Ideas Are Free: How the Idea Revolution Is Liberating People and Transforming Organizations

Front-line employees see a great many problems and opportunities that their managers don’t. Because they are the ones doing the day-to-day work, they are in the best positions to come up with many kinds of ideas—from simple ones on how to save time, effort, and money, to entirely new ways of doing business. Yet most people work in organizations that are far more effective at suppressing their ideas than promoting them. Every day, all over the world, front-line employees watch helplessly as their organizations waste incredible sums of money, needlessly disappoint and lose customers, and miss opportunity after opportunity that to the employees are all too apparent.
Enhancing the settlement and attachment strength of pediveligers of Mytilus galloprovincialis bychanging surface wettability and microtopography

Surface wettability and microtopography can either enhance or deter larval settlement of many sessile marine organisms. This study quantifies the effect of these surface properties on the settlement of pediveligers of Mytilus galloprovincialis, using polymers spanning a range of wettability and microtextured polydimethylsiloxane (PDMS). Furthermore, the adhesion strength of settled pediveligers on microtextured PDMS surfaces was quantified using a flow chamber. Settlement was enhanced at the hydrophilic end of the wettability spectrum, where mean settlement on nylon reached 33.5 ± 13.1%. In contrast, mean settlement on the most hydrophobic polymer (PDMS) was 4.2 ± 3.2%. Microtopography had a much stronger effect compared to wettability, where 400 μm textured PDMS enhanced settlement above 90%. Settlement preferences were also positively correlated to adhesion strength at flow rates of 4 knots, with all initially settled pediveligers on smooth PDMS detaching, while 79.9 ± 5.7% of pediveligers remained on the 400 μm texture.
A Review of Weight Loss Programs Delivered Via the Internet

The escalating obesity epidemic has prompted healthcare professionals to seek interventions that can reach large numbers of individuals in a timely and cost-effective manner. The Internet, with its growing audience, seems an obvious solution. Commercial weight loss programs already abound on the Internet. The purpose of this review is to describe the efficacy of weight loss programs delivered via the Internet in the United States. A search for clinical trials evaluating weight loss via Internet programs was conducted using PubMed, CINAHL, Cochrane Library, Academic Search Premier, the National Institutes of Health Clinical Trials Database, and the Internet as well as a cross-check of reference lists. Eight published studies that met the inclusion criteria were reviewed. Data were extracted on study design, sample characteristics, attrition, weight loss, duration of treatment, and maintenance of weight loss. Of the 8 studies, 3 evaluated the Internet as a means to maintain long-term weight loss. All studies examining weight loss via Internet programs reported positive results, except for one investigating a commercial program. Results from the 3 weight loss maintenance programs conducted on the Internet were equivocal. Because the subjects of all these studies were predominately white, educated women, generalization of findings is limited. Data from the reviewed studies suggest that the Internet may be an alternative to traditional face-to-face weight loss programs. Questions still remain as to the efficacy of using the Internet for long-term weight loss maintenance. Findings from these studies provide beginning guidelines for healthcare providers who may choose to use Internet-based weight loss interventions. Future research is still needed to determine the applicability of such interventions in diverse age, ethnic, and socioeconomic groups.
The natural history of Parkinson's disease

A large body of evidence indicates that the progression of Parkinson's disease (PD) may be fast in the preclinical stage as well as during the first years of the disease, with a subsequent slowing down of the disease process.As has been shown in the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) study, the Unified Parkinson's Disease Rating Scale (UPDRS) motor examination scores declined at a rate of 8 to 9% per year in untreated patients. A subgroup of levodopa-naive DATATOP patients ("survivors") showed a much slower rate of progression, in the order of 3% per year, suggesting a more benign disease course. A number of clinical factors that may govern the rate of motor decline, such as age at onset, disease duration, gender, and clinical phenotype (akinetic-rigid versus tremulous) have been proposed; however, none of them is proven. In contrast, dopaminergic substitution undoubtedly has had a major impact on the natural history of PD, resulting in a reduction of the mortality ratio from about 3.0 to 1.5. This benefit has been noted particularly in patients in whom levodopa therapy was started early. The positive impact of levodopa is largely derived from its symptomatic action; its influence on the disease process itself remains controversial. NEUROLOGY 1996;47(Suppl 3): S146-S152
ALCOHOL TOLERANCE, ADH ACTIVITY, AND ECOLOGICAL NICHE OF DROSOPHILA SPECIES

In vitro alcohol dehydrogenase (ADH) activity was measured in adults of species belonging to Drosophila and to the related genus Zaprionus. Data were analyzed according to the known breeding sites and the level of ethanol tolerance of these species. Alcohol dehydrogenase activity was assayed with both ethanol (E) and isopropanol (I). Our results show a very broad range of activities among the 71 species investigated, the ratio of the highest value observed (D. melanogaster) to the lowest (D. pruinosa) being 65:1. A general positive correlation was found between the level of ADH activity and the capacity to detoxify ethanol. Nevertheless, many species show exceptions to this rule. Contrary to a logical expectation, adaptation to high alcoholic resources, which has been a recurrent evolutionary event, was not mediated by a more efficient use of ethanol, that is, an increase of the E/I ratio. This ratio seems to be quite variable according to the phylogeny and is especially low in the subgenus Sophophora as well as in Zaprionus. Alcohol tolerance clearly is related to the larval habitat of the species and shows that adaptation to alcoholic resources has been a major evolutionary challenge in drosophilids. This adaptation is not related to phylogeny, having occurred independently several times during the evolution of the group. Finally, it should be borne in mind that, besides metabolization and detoxification, other physiological processes such as nervous‐system tolerance or ethanol excretion may be involved in ethanol tolerance, and such functions also should be investigated. Environmental ethanol, which is certainly a major ecological parameter for many drosophilids, has selected a diversity of physiological adaptations, all related to the Adh locus, but presumably much more complicated than was previously believed.
Cold preservation of the porcine pancreas with histidine-tryptophan-ketoglutarate solution.

BACKGROUND Histidine-tryptophan-ketoglutarate (HTK) has been used for experimental and clinical cardiac, renal, and liver transplantation. No experience exists in either experimental or clinical pancreas transplantation. METHODS In the present study, the solution was employed to flush segmental pancreatic grafts and to autotransplant the grafts after 24, 48, and 72 hr of cold storage in a porcine model. The results were compared to those obtained from animals receiving pancreatic grafts flushed and preserved with UW (University of Wisconsin) solution. RESULTS A total of 10 landrace pigs received a graft stored with HTK solution for 24 hr, and 6 animals received a graft stored with UW solution for 24 hr. Daily blood glucose levels were normoglycemic (i.e., blood glucose < 150 mg/dl), and glucosuria was absent in all transplant animals. Intravenous glucose tolerance tests were comparable to two unoperated controls. Seven totally pancreatectomized, nontransplant diabetic controls exhibited daily hyperglycemia, glucosuria (i.e., > 1,000 mg/dl) and highly impaired intravenous glucose tolerance tests (mean K-values of -0.52+/-0.19 vs. -1.25+/-0.46 for HTK, -1.30+/-0.81 for UW, and -1.53+/-0.81 for controls, P-value vs. diabetic <0.01). The changes in wet weight between flushing and reperfusion were +2.22+/-2.84 g for HTK and -1.40+/-2.70 g for UW stored grafts (P=0.034). After 48 hr of storage with HTK, 4/17 grafts were functioning and 1/11 recipients of grafts stored with UW were normoglycemic. All grafts stored for 72 hr in either HTK (n=3) or UW (n=3) uniformly failed to render the recipients normoglycemic. CONCLUSIONS It is concluded that preservation of segmental pancreatic autografts for 24 hr with HTK solution provides reliable graft function, as does preservation with UW solution associated with an increase in wet weight after HTK preservation. Cold preservation with HTK and UW is feasible for 48 hr; however, the success rate is equally reduced with HTK and UW solution. Cold storage for 72 hr in either HTK or UW solution results in uniform graft failure in this model.
Usefulness of a writing device in writer's cramp

Fifteen of 20 patients with writer's cramp treated with a writing device noted an improvement in their writing ability, some quite marked. Despite this benefit, nine patients preferred to use alternate methods. In the absence of adverse effects, we suggest that trials of writing devices be the first recourse for all patients with writer's cramp requiring treatment.