Miracle-dz/UniFAR-FTUs huggingface dataset:
PSYCHIATRIC CARE IN A GENERAL HOSPITAL EMERGENCY ROOM.

Introduction The general purpose of this study is to obtain some understanding of the use of the emergency room in a general hospital as a psychiatric, or in a wider sense, as a psychosocial community resource. Several national surveys 4,8 have disclosed that more and more patients with every kind of problem and complaint are turning for care to general hospital emergency rooms. In a previous paper, 1 we have reviewed possible reasons for this trend and have offered some suggestions regarding the kinds of patients with psychiatric problems who come to the emergency room, why they come at a particular time, and what they hope to achieve as a result of their visit. In this study we intend to present the statistical data on our population focusing on the personal and social characteristics of the patients such as age, sex, race, marital status, area of residence, and socioeconomic group.
Challenges of the coaching manager

This paper explores the growing practice of managerial coaching. Much of the coaching literature is set in the context of an external coach coming into an organisation. However managers are increasingly being expected to coach their employees, a change in role which can create tensions. This paper examines the literature on coaching managers and identifies key differences in the issues faced by coaching managers and by internal/ external coaches. The same coach training is often provided to both full-time coaches and coaching managers. The paper also discusses implications for coach training.
Three Sequenced Legume Genomes and Many Crop Species: Rich Opportunities for Translational Genomics

This year marks the essential completion of the genome sequences of soybean ( Glycine max ), barrel medic ( Medicago truncatula ), and birdsfoot trefoil ( Lotus japonicus ). The impact of these assembled, annotated genomes will be enormous. Birdsfoot trefoil and barrel medic, both forage crops, are
Distribution, evolution, and diversity of retrotransposons at the flamenco locus reflect the regulatory properties of piRNA clusters

Significance Control of transposable elements (TEs) by RNAi has a large impact on genome evolution in higher eucaryotes. In this paper, we study in detail a Piwi-interacting RNA (piRNA)-producing locus of Drosophila melanogaster, flamenco (flam), known to be responsible for the control of at least three retrotransposons by RNAi. We demonstrate the high structural dynamics of the flam locus resulting in loss and gain of TEs and establish a link between such structural variations and its ability to silence retrotransposons. We show that flam is a trap for TEs coming in by horizontal transfer from other Drosophila species. Overall, our data give unique insights into piRNA cluster regulatory properties, their role in evolution, and expansion and taming of TEs. Most of our understanding of Drosophila heterochromatin structure and evolution has come from the annotation of heterochromatin from the isogenic y; cn bw sp strain. However, almost nothing is known about the heterochromatin’s structural dynamics and evolution. Here, we focus on a 180-kb heterochromatic locus producing Piwi-interacting RNAs (piRNA cluster), the flamenco (flam) locus, known to be responsible for the control of at least three transposable elements (TEs). We report its detailed structure in three different Drosophila lines chosen according to their capacity to repress or not to repress the expression of two retrotransposons named ZAM and Idefix, and we show that they display high structural diversity. Numerous rearrangements due to homologous and nonhomologous recombination, deletions and segmental duplications, and loss and gain of TEs are diverse sources of active genomic variation at this locus. Notably, we evidence a correlation between the presence of ZAM and Idefix in this piRNA cluster and their silencing. They are absent from flam in the strain where they are derepressed. We show that, unexpectedly, more than half of the flam locus results from recent TE insertions and that most of the elements concerned are prone to horizontal transfer between species of the melanogaster subgroup. We build a model showing how such high and constant dynamics of a piRNA master locus open the way to continual emergence of new patterns of piRNA biogenesis leading to changes in the level of transposition control.
MARKET SELECTION OF FINANCIAL TRADING STRATEGIES: GLOBAL STABILITY

In this paper we analyze the long‐run dynamics of the market selection process among simple trading strategies in an incomplete asset market with endogenous prices. We identify a unique surviving financial trading strategy. Investors following this strategy asymptotically gather total market wealth. This result generalizes findings by Blume and Easlcy (1992) to any complete or incomplete asset market.
Activation of PPARδ attenuates neurotoxicity by inhibiting lipopolysaccharide‐triggered glutamate release in BV‐2 microglial cells

Neuroinflammation‐associated release of glutamate from activated microglia has been implicated in the progression of neurodegenerative diseases. However, the regulatory mechanisms underlying this glutamate release are poorly understood. Here, we show that peroxisome proliferator‐activated receptor delta (PPARδ) modulates neurotoxicity by inhibiting glutamate release in lipopolysaccharide (LPS)‐activated BV‐2 microglial cells. Activation of PPARδ by GW501516, a specific PPARδ agonist, inhibited glutamate release in BV‐2 cells. This effect of GW501516 was significantly blocked by shRNA‐mediated knockdown of PPARδ and by treatment with GSK0660, a specific PPARδ antagonist, indicating that PPARδ is associated with blockade of glutamate release. Additionally, GW501516‐activated PPARδ suppressed generation of reactive oxygen species and expression of gp91phox, a functional subunit of NADPH oxidase 2, in BV‐2 cells stimulated with LPS. The inhibitory effect of GW501516 on gp91phox expression and glutamate release was further potentiated in the presence of AG490, a specific inhibitor of janus kinase 2 (JAK2), leading to the inhibition of signal transducer and activator of transcription 1 (STAT1). By contrast, GW501516 upregulated the expression of suppressor of cytokine signaling 1 (SOCS1), an endogenous inhibitor of JAK2. Furthermore, neurotoxicity induced by conditioned media from LPS‐stimulated BV‐2 cells was significantly reduced when conditioned media from BV‐2 cells treated with both LPS and GW501516 were used. These results indicate that PPARδ attenuates LPS‐triggered neuroinflammation by enhancing SOCS1‐mediated inhibition of JAK2/STAT1 signaling, thereby inhibiting neurotoxicity associated with glutamate release.
Primary Sjögren's syndrome: role of the HLA-DRB1*0301-*1501 heterozygotes.

OBJECTIVE To examine the respective role of the DRB1*, DQB1*, and DPB1* HLA alleles in primary Sjögren's syndrome (SS) and in the clinical and autoantibody profile of primary SS. METHODS HLA-DRB1*, DQB1*, and DPB1* alleles were analyzed in 42 patients with primary SS and 200 controls by reverse dot blot hybridization for DRB1* and DPB1* and by polymerase chain reaction-restriction fragment length polymorphism for DQB1*. RESULTS We found a significant increase of the HLA-DRB1*15-*03 heterozygote genotype frequency (19% primary SS vs 3.5% controls; p<0.0006, OR=6.49) and especially for the HLA-DRBI*1501-*0301 genotype (16.7% primary SS vs 3% controls; p<0.002, OR=6.47). The DQB1*0201-*0602 genotype was also significantly increased in primary SS (17.1% primary SS vs 4% controls; p<0.006, OR=4.86). However, the higher risk to primary SS development was associated with the DRB1*1501-*0301 genotype (OR=6.47 vs 4.86). There were no differences between patients and controls in DPB1* allele frequencies. The HLA-DRB1*15-*03 heterozygote genotype was also associated with systemic features such as hematologic manifestations and Raynaud's phenomenon (RP) and with autoantibody production such as antinuclear, anti-Ro(SSA) or La(SSB) autoantibodies and rheumatoid factor. CONCLUSION Our data suggest a role of the HLA-DRB1*1501-*0301 heterozygote genotype in susceptibility to primary SS. Moreover, the HLA-DRB1*1501-*0301 genotype was also found to be associated with a particular form of the disease characterized by RP, hematologic manifestations, and autoantibody production.
Robust stability and stabilization of continuous-time infinite Markov jump linear systems

This paper addresses the robust stability and stabilization problems for a class of continuous-time linear systems with Markov jump parameters taking values in a countably infinite set. We consider the problem of robustness against various classes of parametric uncertainty, which extends previous results in the literature. By means of the introduction of novel scaling techniques, it is shown how less conservative robust stability margins and robust controllers can be obtained by the solution of linear matrix inequality problems. The effectiveness of the obtained results is illustrated with a numerical example.
Multisystemic Treatment of Antisocial Adolescents in Norway: Replication of Clinical Outcomes Outside of the US.

BACKGROUND MST is an intensive home- and community-based intervention for youths with serious antisocial behaviour and other serious clinical problems, which has been effective at reducing out-of-home placements and producing favourable long-term clinical outcomes in the US. The aims of the study were to determine the degree to which these outcomes would be replicated in Norway for youths with serious behaviour problems and to conduct a randomised trial of MST by an independent team of investigators. METHOD Participants were 100 seriously antisocial youths in Norway who were randomly assigned to Multisystemic Therapy (MST) or usual Child Welfare Services (CS) treatment conditions. Data were gathered from youths, parents, and teachers pre- and post-treatment. RESULTS MST was more effective than CS at reducing youth internalising and externalising behaviours and out-of-home placements, as well as increasing youth social competence and family satisfaction with treatment. DISCUSSION This is the first study of MST outside of the US and one of the first not conducted by the developers of MST. The findings replicate those obtained by MST's developers and demonstrate the generalisability of short-term MST effects beyond the US.
The impact of users' verbal/imagery cognitive styles on their Web search behavior

Purpose – The purpose of this paper is to investigate the effects of verbal-imagery cognitive styles of information searching behavior of users in using the Web. Design/methodology/approach – In all, 44 participants were recruited for this study. The participants’ cognitive styles were measured by using Riding's Cognitive Style Analysis test. Three search tasks were designed based on Kim's search task definitions. Moreover, an individual lab session was arranged and then participants’ memos were analyzed using content analysis. Findings – In all, 48 strategies in four categories of behaviors in searching the Web were identified. There were associations between users’ cognitive styles and their information searching behavior. The participants’ selection of the search initiation behaviors varied, so that imagers suffered from more varied initial behavior than verbalizers. The verbalizers tended to search in a narrow area, then broadening the area and following structured navigation and reading behavior to p.
Validity of Self-Reported Physical Fitness and Body Mass Index in a Military Population

Abstract Martin, RC, Grier, T, Canham-Chervak, M, Anderson, MK, Bushman, TT, DeGroot, DW, and Jones, BH. Validity of self-reported physical fitness and body mass index in a military population. J Strength Cond Res 30(1): 26–32, 2016—Many epidemiological studies rely on valid physical fitness data. The purpose of this investigation was to assess the validity of self-reported Army Physical Fitness Test (APFT) data and determine whether men and women recall APFT performance differently. U.S. Army soldiers (N = 1,047) completed a survey, including questions on height, weight, and most recent APFT performance. Height, weight, and APFT performance were also obtained from unit records. The mean ± SDs for unit and self-reported push-up repetitions were 63.5 ± 13.1 and 66.3 ± 14.0 for men and 37.7 ± 12.8 and 40.2 ± 12.8 for women, respectively. The mean ± SD for unit- and self-reported sit-up repetitions were 66.3 ± 11.4 and 68.1 ± 12.1 for men and 64.2 ± 13.6 and 66.5 ± 12.9 for women, respectively. The mean ± SD unit- and self-reported 2-mile run times were 15.2 ± 1.8 and 14.9 ± 1.6 minutes for men, and 18.0 ± 2.9 and 17.4 ± 1.9 minutes for women, respectively. Unit- and self-reported body mass indices (BMIs) (calculated by height and weight) were 26.4 ± 3.4 and 26.3 ± 3.6 for men and 24.6 ± 2.8 and 24.2 ± 3.3 for women. Correlations between unit- and self-reported scores for push-ups, sit-ups, 2-mile run, height, weight, and BMI were 0.82, 0.78, 0.85, 0.87, 0.97, and 0.88 for men and 0.86, 0.84, 0.87, 0.78, 0.98, and 0.78 for women, respectively. On average, men and women slightly overreported performance on the APFT and overestimated height, resulting in underestimated BMI. There was no difference in recall ability between men and women (p > 0.05). The very good to excellent correlations (r = 0.78–0.98) between unit- and self-reported scores indicate that self-reported data are valid for capturing physical fitness performance in this population.
Knowledge sharing behavior in learning online communities: A social capital perspective

Learning online communities enabled a new way of knowledge sharing and innovation. Adopting a social perspective and drawing on social capital theory, this paper investigated how dimensions of members' social capital interacting influenced on knowledge sharing behavior in learning online community. With 478 valid responses from an online survey, the study tested hypotheses about relationships of social interaction ties, reciprocity, trust, shared vision and knowledge sharing behavior. The analytical results demonstrated that reciprocity and social interaction ties exerted significant impacts on knowledge sharing in learning online communities. The implications of the study findings were finally discussed.
Clinical and radiologic predictive factors of septic hip arthritis.

OBJECTIVE The purpose of our study was to identify the clinical and radiologic factors associated with a positive culture during image-guided hip joint aspiration. MATERIALS AND METHODS We performed a retrospective analysis of 167 consecutive hip aspirations for septic arthritis at a large tertiary medical center. Chart review was performed on the following clinical factors: serum WBC count≥11×10(3)/μL, serum erythrocyte sedimentation rate (ESR)≥20 mm/h, C-reactive protein (CRP)≥100 mg/L, synovial fluid WBC count, synovial fluid polymorphonuclear (PMN) leukocytes≥90%, fever, immunosuppression, antibiotic use, diabetes, presence of a prosthesis, and IV drug use (IVDU). Radiologic studies were reviewed for the following imaging and technical factors: presence of a sinus tract, fluid turbidity, volume of fluid (mL) aspirated, and whether the fluid analyzed was primarily aspirated or reaspirated after lavage. Logistic regression was used to calculate odds ratio (OR) and 95% CI. RESULTS Of the 167 aspirations, 29 (17.4%) had positive cultures; 6 of 29 (20.7%) positive cultures occurred in reaspirated lavage fluid. On multivariate analysis using logistic regression with stepwise backward elimination, the significant clinical and radiologic predictors were elevated WBC (OR, 4.4; 95% CI, 1.1-17.3), high percentage of synovial fluid PMN leukocytes (OR, 10.6; 95% CI, 2.9-39.8), IVDU (OR, 9.0; 95% CI, 1.3-64.7), and fluid turbidity (OR, 20.5; 95% CI, 6.9-61.4). CONCLUSION Positive hip cultures are associated with elevated serum WBC, IVDU, high percentage of synovial fluid PMN leukocytes, and fluid aspirate turbidity. Reaspiration of lavage fluid with either nonbacteriostatic saline or contrast material can yield positive cultures.
Self-Efficacy and Resilience in Baccalaureate Nursing Students

The attrition of admitted students from nursing programs has been attributed to the perceived stress of nursing school. Students who possess the characteristics of self-efficacy and resilience may be persistent and therefore academically successful as demonstrated by test scores over the course of their education. In this article, the authors report on a study that explored self efficacy and resilience in relation to test scores among 136 baccalaureate nursing students in multiple courses during one, 16 week semester. No statistically significant differences were found in perceived self-efficacy or resilience total scores between early semester and late semester measurements. Significant differences were found on the Resilience Scale subscales of Perseverence and Existential Aloneness. Test scores were weakly correlated with resilience and self-efficacy scores.
Fear of recurrence and psychological distress in head and neck cancer patients and their carers

Background: Fear of recurrence (FOR) has been increasingly recognised as an issue of significant burden for most cancer patients, and has been associated with psychological morbidity and reduced quality of life. More recently, the impact of recurrence fears has been indicated in the families of cancer patients. However, there has been a lack of prospective research.
Generation of confluent cardiomyocyte monolayers derived from embryonic stem cells in suspension: a cell source for new therapies and screening strategies.

BACKGROUND Cellular cardiomyoplasty is evolving as a new strategy to treat cardiac diseases. A prerequisite is a reliable source of pure cardiomyocytes, which could also help in the exploitation of recent advances in genomics and drug screening. Our goal was to establish a robust lab-scale process for the generation of embryonic stem (ES)-cell-derived cardiomyocytes in suspension. METHODS A 71 ES cell clone carrying a construct consisting of the alpha-cardiac myosin heavy chain (alphaMHC) promoter driving the neomycin resistance gene was used for antibiotic-driven cardiomyocyte enrichment. Rotating suspension culture was established to initiate embryoid body (EB) formation. To track growth and differentiation kinetics, cell count and flow cytometry for SSEA-I, E-cadherin (stem-cell marker)and sarcomeric myosin (cardiomyocytes marker) was performed. Oct4 expression was measured via real time (RT)-PCR. RESULTS Cultures comprising 2.5-8 x 10(6) differentiating FS cells/mL were obtained after 9 days in rotating suspension. Upon G418 addition,vigorous contracting spheres, termed cardiac bodies (CB), developed. These cultures consisted of about 2.1 x 10(5) enriched cardiomyocytes/mL after 6- 10 days of selection. Suspensions comprising 90- 95%viable single cells were generated using an improved dissociation method. Seeding of cardiomyocytes with 7 x 10(4) cell/cm(2) resulted in a homogeneous monolayer of synchronously contracting cells. Myocyte specific immunohistochemistry indicated purity of > 99%. DISCUSSION We have established a reliable lab-scale protocol to generate cultures of highly enriched cardiomyocytes in suspension. This will facilitate development of larger-scale processes for stem-cell based cardiomyocyte supply. An improved method is provided to derive vital suspensions of cardiomyocytes, which could be utilized for transplantation as well as for drug screening purposes.
Popliteal Fossa Neural Blockade as the Sole Anesthetic Technique for Outpatient Foot and Ankle Surgery

Foot and ankle operations are being performed with greater frequency as outpatient procedures. Although the surgical procedure remains the same whether the operation is done in an inpatient or an oupatient setting, the anesthesia and postoperative analgesia are greatly affected when patients must be discharged soon after their operation. We have evaluated a regional anesthetic technique which blocks the sciatic nerve in the popliteal fossa and the saphenous nerve block at the knee. This was the sole anesthetic technique for both the operation and the immediate postoperative period. This technique appears to have several advantages: 1) Excellent anesthesia during the operation and for about ten hours postoperatively; 2) Use of a proximal calf tourniquet, and 3) Absence of systemic or local complications as might be seen with general, spinal or epidural anesthesia.
Supplemental Information Running Title : Global Signal in Schizophrenia 1 SUPPLEMENTAL INFORMATION Altered Global Brain Signal in Schizophrenia

1. Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA 2. Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06520, USA 3. Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA 4. Center for Neural Science, New York University, New York, NY 06510, USA 5. Department of Psychology, University of Ljubljana, Ljubljana, Slovenia 6. Center for Molecular & Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA 7. University Psychiatric Hospital Vrapce, University of Zagreb, Zagreb 10000, Croatia 8. NIAAA Center for the Translational Neuroscience of Alcoholism, New Haven, CT 06519, USA 9. Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA 10. Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, 200 Retreat Avenue, CT 06106, USA 11. Department of Psychology, Yale University, 2 Hillhouse Avenue, CT 06520, USA 12. Department of Anatomy and Neurobiology, Washington University in St. Louis, MO 63130, USA 13. NYU-ECNU Joint Institute of Brain and Cognitive Science, NYU-Shanghai, Shanghai, China
Altered Perceptions of Personal Control About Retained Weight and Depressive Symptoms in Low-Income Postpartum Women

Postpartum weight retention and depressive symptoms have a high prevalence among low income women. This qualitative study describes low-income women's experiences of weight changes and depressive symptoms during the late postpartum period. Women (n = 25) who were either overweight or had depressive symptoms, or both, at 12 months postpartum participated in an ethnically-congruent focus group. Women's experiences indicated altered personal control related to retained postpartum weight and depressive feelings. Retained weight negatively affected self-esteem and family functioning. Depression left women feeling isolated yet reluctant to seek help. These findings could provide the basis for health promotion interventions relevant to this population.