Miracle-dz/UniFAR-FTUs huggingface dataset:
Development and Validation of Spectrophotometric and Pre-column Derivatization HPLC Method for Determination of Famotidine in Pharmaceuticals by Reaction with Sodium Nitroprusside; Application to Combined Tablets

Spectrophotometric and HPLC methods for estimation of famotidine in pharmaceutical formulations through derivatization with sodium nitroprusside were developed. The spectrophotometric method is based on measuring the red color formed after the reaction with sodium nitroprusside at 498 nm. The formed product was further determined by HPLC method using C18 column, mobile phase composed of methanol and 0.05 M phosphate buffer (30:70, v/v) with apparent pH 4, The UV detection was at 498 nm. Both methods were linear covering concentrations of 20-500 μg/mL. The selectivity and the simplicity of the methods allow the successful estimation of famotidine in its pharmaceuticals and in its combined tablets with ibuprofen, domperidone, paracetamol and diclofenac without interferance.
Polysomnography in a Large Population Based Study-the Study of Health in Pomerania Protocol

Background: Our current knowledge about sleep disorders in the general population is limited by a lack of objective sleep data assessed in large-scale, well characterised European cohorts. The Study of Health in Pomerania (SHIP) is a population-based study investigating prevalence and incidence of common risk factors, subclinical disorders and clinical diseases in adults. Polysomnography (PSG) was performed between 2008 and 2012 (SHIP-TREND). Aim: The aim of the present study was to perform cardiorespiratory PSG in a populationbased setting to gain more insight into subclinical and clinical sleep disorders and their complex associations with common risk factors, subclinical disorders and chronic diseases among adults. Here we describe the rationale, design, and implementation of PSG in a population-based study. Methods: The Study of Health in Pomerania (SHIP) consists of two independent population-based prospective subcohorts. The core diagnostic program of the baseline SHIP-TREND included the assessment of risk behaviour, common chronic diseases, cardiac, vascular, pulmonary, and serum blood parameters, mental health, and cognitive functioning. Genotyping and whole-body MRI were also performed. In addition, all participants were offered a standard overnight laboratory-based polysomnography (PSG). Subjective sleep parameters and restless legs syndrome (RLS) were assessed with a set of standardised questionnaires. Sleep staging, respiratory events, and leg movements were evaluated according to the standards of the American Academy of Sleep Medicine (AASM). Results: Complete data (sleep-questionnaires, PSG) have been obtained on 1249 participants (573 women), aged 20-70 years. Genetic data are available from 424 PSG participants. Conclusion: The population-based design and the comprehensive data collection provide a unique opportunity to assess the prevalence and risk factors of sleep disorders, and to investigate the complex relationships between sleep parameters, genetic factors, and various health and disease aspects.
Gluttony in migratory waders: unprecedented energy assimilation rates in vertebrates

Maximum energy assimilation rate has been implicated as a constraint on maximal sustained energy expenditure, on biomass production, and in various behavioural and life history models. Data on the upper limit to energy assimilation rate are scarce, and the factors that set the limit remain poorly known. We studied migratory waders in captivity, given unlimited food supply around the clock. Many of these waders assimilated energy at rates of seven to ten times basal metabolism, exceeding maximum rates reported for vertebrates during periods of high energy demand, for example during reproduction and in extreme cold. One factor allowing the high energy assimilation rates may be that much of the assimilated energy is stored and not concomitantly expended by muscles or other organs. The remarkable digestive capacity in waders is probably an adaptation to long and rapid migrations, putting a premium on high energy deposition rates. The upper limit to daily energy assimilation in vertebrates is clearly higher than hitherto believed, and food availability, total daily feeding time and, possibly, the fate of assimilated energy may be important factors to take into account when estimating limits to energy budgets in animals.
Contextual Performance in Academic Settings: the Role of Personality, Self-efficacy, and Impression Management

espanolEl proposito principal de esta investigacion ha sido analizar el papel predictor de las dimensiones de la personalidad, la percepcion de autoeficacia y el manejo de la imagen en el desempeno contextual en entornos academicos. La muestra estuvo compuesta por 223 estudiantes universitarios, que cumplimentaron una bateria de cuestionarios a traves de una aplicacion informatica. Los resultados mostraron que responsabilidad, extraversion y amabilidad son las dimensiones de personalidad que, junto con autoeficacia, predicen la autoevaluacion del desempeno contextual. Ademas, la variable responsabilidad interactua con la autoeficacia, de modo que el papel predictivo de dicha variable de personalidad se incrementa a medida que aumenta la autoeficacia. Por otra parte, el manejo de la imagen explico parte de la varianza de desempeno contextual autoevaluado, pero no interactuo con las restantes variables. Los resultados obtenidos respecto a las dimensiones de personalidad y la autoeficacia son coherentes con los encontrados en contextos laborales. EnglishThe main purpose of this paper was to analyse the predictive role of personality, self-efficacy, and impression management on contextual performance in academic settings. A sample of 223 university students voluntarily answered a battery of tests on-line. Results showed that conscientiousness, extraversion, and agreeableness, as well as self-efficacy, predict contextual performance self-evaluations. Furthermore, the significant interaction between conscientiousness and selfefficacy multiplies their influence. Besides, impression management contributes to predicting contextual performance, but did not interact with the remaining variables. Results related to personality and self-efficacy are consistent with those found in work settings.
THE BURDEN OF INFECTIONS BY PARAINFLUENZA VIRUS IN HOSPITALIZED CHILDREN IN SPAIN

Prevalence of parasites, acquired by the fecal-oral route, was recorded in 80% of primary school children with a finger-sucking habit, which was higher than that in nonfinger-sucking children. About 85% of the children did not wash their hands after defecation. The toilet facility available to the children also affected the infection pattern in fingersucking children who used pit latrines recording higher prevalence of
The Political Cycle of Corporate Investments: New Evidence from Chinese Manufacturing Firms

Using a comprehensive dataset of industrial firms and government official turnovers at the prefecture level in China, we show that firms significantly increase their investments right before expected turnovers of prefecture governors. More importantly, we find that the increase in investment mainly comes from privately owned firms, especially for politically connected firms and firms affiliated with governments below the prefecture level. The effect is stronger among officials with stronger career incentive and in provinces with weaker institutions. Our results suggest that the career incentive of local government officials and political connections play an important role in generating the political cycle of corporate investment in China. JEL Classification: G30, G31, G32, G38
Serendipitous discovery of a thin stellar stream near the Galactic bulge in the Pan-STARRS1 3π Survey

We report the discovery of a thin stellar stream found in Pan-STARRS1 photometry near the Galactic bulge in the constellation of Ophiuchus. It appears as a coherent structure in the colour-selected stellar density maps produced to search for tidal debris around nearby globular clusters. The stream is exceptionally short and narrow; it is about 2 ∘. 5 long and 6 arcmin wide in projection. The colour–magnitude diagram of this object, which harbours a blue horizontal-branch, is consistent with an old and relatively metal-poor population ([Fe/H] ∼−1.3) located 9.5 ± 0.9 kpc away at (l, b) ∼ (5°, +32°), and 5.0 ± 1.0 kpc from the Galactic centre. These properties argue for a globular cluster as progenitor. The finding of such a prominent, nearby stream suggests that many streams could await discovery in the more densely populated regions of our Galaxy.
Psoriasis is more than a skin disorder : an ACE study

Introduction: Psoriasis is now known to be a systemic autoimmune disease with an associated increased cardiovascular risk. This seems to rely on systemic inflammation. Angiotensin-converting enzyme (ACE) has been associated with oxidative stress, a state characteristic of cardiovascular disorders and this enzyme’s activity is higher in psoriasis. Our aim is to assess cardiovascular risk in psoriatic patients and its association with ACE polymorphism and activity. Methods: Our population consisted of 1155 individuals (64 psoriatic patients, 1091 controls) whose ACE genotype and activity were determined. The cardiovascular risk was estimated through lipid profiles. PASI score was used as a severity measurement. Results: Psoriatic severity was associated with a higher cardiovascular risk estimated by lower HDL concentrations (r=-0.496, p=0.007) and higher triglyceride levels (r=0.421, p=0.020), as well as TC/HDL and LDL/HDL ratios (r=0.612, p<0.001 and r=0.437, p=0.023, respectively) which have been shown to have stronger predictive value for cardiovascular disorders Conclusions: Psoriatic patients should be treated as a risk group for cardiovascular diseases and new markers for severity and this associated risk may be of worthy pursuit. Further studies are crucial to enhance our knowledge on inflammation and psoriasis.
Modeling p CO 2 variability in the Gulf of Mexico

Abstract. A three-dimensional coupled physical–biogeochemical model was used to simulate and examine temporal and spatial variability of sea surface pCO2 in the Gulf of Mexico (GoM). The model was driven by realistic atmospheric forcing, open boundary conditions from a data-assimilative global ocean circulation model, and observed freshwater and terrestrial nutrient and carbon input from major rivers. A 7-year model hindcast (2004–2010) was performed and validated against ship measurements. Model results revealed clear seasonality in surface pCO2 and were used to estimate carbon budgets in the Gulf. Based on the average of model simulations, the GoM was a net CO2 sink with a flux of 1.11 ± 0.84 × 1012 mol C yr−1, which, together with the enormous fluvial inorganic carbon input, was comparable to the inorganic carbon export through the Loop Current. Two model sensitivity experiments were performed: one without biological sources and sinks and the other using river input from the 1904–1910 period as simulated by the Dynamic Land Ecosystem Model (DLEM). It was found that biological uptake was the primary driver making GoM an overall CO2 sink and that the carbon flux in the northern GoM was very susceptible to changes in river forcing. Large uncertainties in model simulations warrant further process-based investigations.
An Exercise into Sex Fixing of Progenies in Dairy Animals and Calculating the Impact Factor of Such a Drug Discovery with Reference to Indian Conditions

Sex fixing of mammalian progenies is one of the most fascinating subjects ever reported and it can be a formidable tool in increasing dairy productivity as well as ensuring considerable economic and social benefits. There have been many recorded attempts to produce sexed off-springs in mammals and most of them involved semen sexing methodologies. The present methodology involves a novel in vivo technology duly patented and which uses the administration of a liquid dosage form which has active ingredients like monosodium ethanoate and ethanoic acid which when given orally to females of dairy animals; yields female off-springs with impressive success rate. A huge trial of this methodology was conducted in real field conditions in Gujarat and the outcome was impressive.
Chemical composition, antimicrobial, and cytotoxic assessment of Mitracarpus scaber Zucc. (Rubiaceae) essential oil from southwestern Nigeria

The leaf essential oil composition of Mitracarpus scaber was determined by GC-MS. The oil was dominated by pentadecanal (38.5%), methyl (7Z, 10Z, 13Z)-hexadecatrienoate (11.8%), 2,3dimethylnaphthoquinone (6.0%), and α-pinene (5.4%). The oil was screened for antimicrobial activity using the broth dilution technique and screened for in-vitro cytotoxic activity against human MCF-7 breast tumor cells. M. scaber leaf oil showed only marginal antibacterial activity against Bacillus cereus (MIC = 625 μg/mL), marginal antifungal activity against Aspergillus niger (MIC = 313 μg/mL), and marginal cytotoxic activity on MCF-7 cells (58.7±7.6% kill at 100 μg/mL).
Influence of one-level cervical disc arthroplasty and anterior cervical decompression and fusion on adjacent segment degeneration : a comparative study with two-year follow up

To compare the morbidity of adjacent segment degeneration (ASD) in patients who underwent cervical disc arthroplasty (CDA) and anterior cervical decompression and fusion (ACDF). ACDF used to be considered as the best treatment of cervical degenerative disc disease. It’s controversial when ASD was reported as complication after ACDF. CDA was believed to maintain the physiological motion pattern and reduce intervertebral stress. There are few reports comparing the results of two surgeries. Patients undergoing CDA or ACDF from February 2007 to August 2008 got a minimum follow-up of 4 years. The cohort consisted of 150 patients (69 men and 81 women) with an average age of 46.7±6.5 years. 45 patients were treated with CDA and 105 patients underwent ACDF. The efficacy was evaluated with the visual analog scale (VAS), the neck disability index (NDI), Japanese Orthopaedic Association (JOA) score and the range of motion (ROM). The anteroposterior and lateral radiographs and over flexion-extension lateral radiographs were obtained. Cervical CT and MRI were obtained if persistent discomforts or new symptoms were claimed. The revised Hilibrand method was adopted to assess the level of ASD. All the 150 patients complete the clinical and radiological follow-up interval (48 months). From investigation, the preservation of motion was notably maintained in the CDA patients. However, there were no statistically significant difference of the ASD incidence based on the VAS, NDI and JOA scores between the two groups. Therefore, the role of CDA in ASD incidence remains unclear unless more randomized controlled trials are conducted and definitive evidence is achieved. CDA significantly increased ROM comparing to ACDF. However, the other scores were not significant different between two groups. More data are needed for solid conclusion.
Dual-tasking and aging—About multiple perspectives and possible implementations in interventions for the elderly

Abstract It is well known that dual-tasking is adversely affected by physiological degenerative processes. Furthermore, the completion of a secondary task while walking is frequently discussed as a key contributor for falls in the elderly. Age-related differences in both activated neural structures and human behavior are indicated in numerous previous studies. Besides a general overview of dual-tasking and aging, this article reviews studies aiming at improving gait or postural control in older adults using dual- or multi-task interventions. Approximately, 130 parameters out of 17 illustrated studies presented significant changes after dual-task-specific interventions regarding gait, postural control/balance, and falls. On the one hand, the article at hand shows highly consistent results in all of the dual-task intervention studies analyzed, indicating significant improvements related to postural control, gait, falls, or the performance of a secondary task. On the other hand, the results represent a heterogeneous structure and a gap between theoretical aspects and practical use. To optimize the use of dual-task, a systematization of underlying tasks is inevitable and should be focused on in further research.
Consensus control of second‐order delayed multiagent systems with intrinsic dynamics and measurement noises

This paper studies the consensus control of second‐order multiagent systems with intrinsic dynamics based on delayed and noisy measurements, where the delays in the position and velocity measurements are allowed to be different. The nonlinear and linear intrinsic dynamics are considered, respectively. For the case with nonlinear dynamics, mean square and almost sure consensus conditions are established by applying the degenerate Lyapunov functional and stochastic stability theorems. For the delay‐free case with linear dynamics, appropriate Lyapunov functions are established to get some simple sufficient conditions for mean square and almost sure consensus, and necessary conditions for mean square consensus. It is shown that, with respect to the weighted average type control protocols, second‐order multiagent systems are kept mean square consentable under multiplicative measurement noises alone or intrinsic dynamics alone, but may become unconsentable due to the coexistence of multiplicative noises and intrinsic dynamics. These results are further extended to leader‐following multiagent systems.
On-the-fly deterministic binary filters for memory efficient keyword spotting applications on embedded devices

Lightweight keyword spotting (KWS) applications are often used to trigger the execution of more complex speech recognition algorithms that are computationally demanding and therefore cannot be constantly running on the device. Often KWS applications are executed in small microcontrollers with very constrained memory (e.g. 128kB) and compute capabilities (e.g. CPU at 80MHz) limiting the complexity of deployable KWS systems. We present a compact binary architecture with 60% fewer parameters and 50% fewer operations (OP) during inference compared to the current state of the art for KWS applications at the cost of 3.4% accuracy drop. It makes use of binary orthogonal codes to analyse speech features from a voice command resulting in a model with minimal memory footprint and computationally cheap, making possible its deployment in very resource-constrained microcontrollers with less than 30kB of on-chip memory. Our technique offers a different perspective to how filters in neural networks could be constructed at inference time instead of directly loading them from disk.
Students ' Birth Order , School Type and Truancy among Senior Secondary School Students in Niger State , Nigeria : Implications for Counseling

he study determined relationship between students' birth order, school Ttype and truancy among senior secondary school students in Niger State, Nigeria. Two objectives were stated and two null hypotheses were tested. Correlation design was employed for the study. The target population for the study comprised of all the truant senior secondary school students in their first year (SS1) and their parents in Niger State. The population of SSI in Niger State was 75,383 students, however, four hundred truant SSI students and their parents constituted the sample of the study, which was drawn purposively from the selected 24 schools in 8 education zones of Niger State. Parents Questionnaire (PQ) and Performa on Truancy among Senior Secondary School Students' (PTSSSS) were used for data collection. The PQ was validated using split-half method and reliability coefficient of . 72 was found which shows that the instrument was reliable for the purpose of this study. The data collected for the study was analyzed using chi-square and ttest of independent samples. The results were considered at P<. 05 level. The findings of the study revealed that there was significant relationship between students' birth order and truancy among senior secondary school students in Niger State. It is further discovered that there was no significant difference between the mean truancy of boarding and day schools among senior secondary school students in Niger State. Based on findings of the study the researchers concluded that being lastborns is one of the factors responsible for truancy among secondary school students. It was also concluded that family factors can influence truancy higher than school factors among secondary school students.
Correlation of Endometrial Thickness and Histopathology in Women with Abnormal Uterine Bleeding

Aim: The study was aimed to reveal endometrial thickness measured by transvaginal sonography (TVS) and various clinical factors with histopathology in women with abnormal uterine bleeding and to evaluate the accuracy of transvaginal sonography in detecting intrauterine abnormalities as compared to hysteroscopy. Methods: In this prospective study transvaginal sonography was performed in 163 women with abnormal uterine bleeding, followed within 48 hours by hysteroscopy and endometrial biopsy. Statistical analysis was performed by chi-square test and the various correlations were calculated. Results: No statistically significant association was found between endometrial thickness and cycle day with histopathology. One of the women with endometrial thickness of <5 mm had malignancy. There was a highly significant association between menstrual status and histology. Transvaginal sonography and hysteroscopy were in agreement in 79.14% of the patients. Conclusions: Based on our results, echomorphological measures can provide critical information for a conclusive diagnosis. We recommend using a combination of metric and morphological parameters when performing a sonographic assessment of the endometrium in postmenopausal women. Endometrial biopsy should be performed to exclude endometrial hyperplasia and carcinoma in postmenopausal women with endometrial bleeding to perform proper and prompt treatment, especially in old aged women.
Histological, Histochemical and Ultra Structural Studies of Ileum of Goat (Capra hircus)

The tissues from ileum were collected from six young goats and processed for light microscopy, scanning and transmission electron microscopic studies. The villi of the ileum varied in shape and size. These were lined by simple columnar epithelium with few goblet cells. The intestinal glands were simple tubulo-acinar type having simple cuboidal to low columnar epithelium. Lamina muscularis mucosae was thin and interrupted. The submucosa was having loose irregular connective tissue and occupied by lymphoid nodules or Peyer’s patches consisted of follicles of various shapes and size. Tunica muscularis had inner circular and outer longitudinal layers of smooth muscles. Histochemical studies presented presence of glycogen and acidic and neutral mucopolysaccharides in the intestinal glands. The scanning electron microscopy showed tongue shaped villi with distinctive corrugation on its surface. The transmission electron microscopy showed presence of simple columnar cells with microvilli in surface epithelium. The cryptal epithelium was having Paneth, enterochromaffin and goblet cells.