Miracle-dz/UniFAR-FTUs huggingface dataset:
National survey of pandemic influenza A (H1N1) 2009‐associated encephalopathy in Japanese children

The novel pandemic (pdm) influenza A (H1N1) 2009 virus caused an epidemic of critical illness, with some patients developing severe acute respiratory distress syndrome. Pdm H1N1 2009 infection has been reported to cause fatal encephalopathy and myocarditis as well as pneumonia. To investigate the actual characteristics of the encephalopathy associated with pdm H1N1 2009 infection in Japan, questionnaires were distributed and information collected on 207 cases of encephalopathy during one season. The results of the survey showed that encephalopathy was reported predominantly in males. The outcome was recorded in 188 of the 207 cases; 16 of 188 patients (8.5%) died, while 23 (12.2%) had sequelae. Serious cases were distributed across all age groups. Febrile convulsion was noted at a higher rate in medical past‐history in cases without sequelae (40 of the 149 cases; 27%) than in serious cases. In contrast, pre‐existing epilepsy and mental retardation were observed more frequently in serious cases. Twelve cases exhibited biphasic seizures; one‐half of these had sequelae, but none was fatal. Ten cases were accompanied by high cytokine levels, and three of these children died. Among the 149 cases with good outcomes, 29 of 116 cases (25%) showed abnormalities on MRI, and 14 of these demonstrated reversible splenial lesions. Abnormal behaviors, especially delirium and visual hallucinations, were observed more frequently in cases without sequelae. In conclusion, pdm H1N1 2009 infection‐associated encephalopathy was a critical disease in children, with rapidly progressive characteristics similar to those of seasonal influenza‐associated encephalopathy. J. Med. Virol. 84: 1151–1156, 2012. © 2012 Wiley Periodicals, Inc.
Perineal stapled prolapse resection for full‐thickness external rectal prolapse: a multicentre prospective study

Many different surgical techniques have been reported for the surgical treatment of full‐thickness external rectal prolapse. Perianal stapled prolapse resection (PSP) is a relatively newly reported technique for full thickness external rectal prolapse. The aim of this prospective multicentre study was to evaluate the results of this procedure.
Coherent evidence from Aquarius and Argo for the existence of a shallow low‐salinity convergence zone beneath the Pacific ITCZ

Aquarius observations feature a prominent zonal sea-surface salinity (SSS) front that extends across the tropical Pacific between 2–10°N. By linking to Argo subsurface salinity observations and satellite-derived surface forcing datasets, the study discovered that the SSS front is not a stand-alone feature; it is in fact the surface manifestation of a low-salinity convergence zone (LSCZ) located within 100 m of the upper ocean. The near-surface salinity budget analysis suggested that, although the LSCZ is sourced from the rainfall in the Inter-tropical convergence zone (ITCZ), its generation and maintenance are governed by the wind-driven Ekman dynamics, not the surface evaporation-minus-precipitation flux. Three distinct features highlight the relationship between the oceanic LSCZ and the atmospheric ITCZ. First, the seasonal movement of the LSCZ is characterized by a monotonic northward displacement starting from the near-equatorial latitudes in boreal spring, unlike the ITCZ that is known for its seasonal north-south displacement. Second, the lowest SSS waters in the LSCZ are locked to the northern edge of the Ekman salt convergence throughout the year, but have no fixed relationship with the ITCZ rain band. Collocation between the LSCZ and ITCZ occurs only during August-October, the time that the ITCZ rain band coincides with the Ekman convergence zone. Lastly, the SSS front couples with the Ekman convergence zone but not the ITCZ. The evidence reinforces the findings of the study that the Ekman processes are the leading mechanism of the oceanic LSCZ and the SSS front is the surface manifestation of the LSCZ.
Paper- and computer-based workarounds to electronic health record use at three benchmark institutions.

BACKGROUND Healthcare professionals develop workarounds rather than using electronic health record (EHR) systems. Understanding the reasons for workarounds is important to facilitate user-centered design and alignment between work context and available health information technology tools. OBJECTIVE To examine both paper- and computer-based workarounds to the use of EHR systems in three benchmark institutions. METHODS Qualitative data were collected in 11 primary care outpatient clinics across three healthcare institutions. Data collection methods included direct observation and opportunistic questions. In total, 120 clinic staff and providers and 118 patients were observed. All data were analyzed using previously developed workaround categories and examined for potential new categories. Additionally, workarounds were coded as either paper- or computer-based. RESULTS Findings corresponded to 10 of 11 workaround categories identified in previous research. All 10 of these categories applied to paper-based workarounds; five categories also applied to computer-based workarounds. One new category, no correct path (eg, a desired option did not exist in the computer interface, precipitating a workaround), was identified for computer-based workarounds. The most consistent reasons for workarounds across the three institutions were efficiency, memory, and awareness. CONCLUSIONS Consistent workarounds across institutions suggest common challenges in outpatient clinical settings and failures to accommodate these challenges in EHR design. An examination of workarounds provides insight into how providers adapt to limiting EHR systems. Part of the design process for computer interfaces should include user-centered methods particular to providers and healthcare settings to ensure uptake and usability.
Investigating the meaning of supplier-manufacturer partnerships : an exploratory study

Supplier partnerships can be the key in enhancing the performance of manufacturing companies. Consequently, partnership has been strongly recommended by academics and practitioners alike. Surprisingly, the concept of partnership is only poorly understood. Many authors have identified the advantages that it can bring but far less has been published on the attributes of partnership itself. What is known is that partnerships are “close” relationships and thus, the level of relationship closeness is an appropriate angle for exploring supplier partnerships. Research was conducted using the repertory grid technique with an exploratory sample of ten managers from four German engineering companies. It revealed that supplier partnerships are very different from other forms of relationship and identified five distinct attributes of partnerships. These findings have a number of implications for both practitioners and researchers.
The Mediating Effects of Sleep in the Relationship Between Traumatic Stress and Health Symptoms in Urban Police Officers

Objective Posttraumatic stress symptoms have been associated with increased health problems across numerous studies. Sleep disruption, one of the principal symptoms resulting from traumatic stress, has also been shown to produce health problems. This study explored the hypothesis that the relationship between posttraumatic stress symptoms and health is mediated by sleep problems. Method A sample of 741 police officers were administered measures of traumatic stress symptoms, sleep, health functioning, and somatic symptoms. Results Traumatic stress symptoms were significantly related to both somatic symptoms (R2 = 0.18, p < .001) and health functioning (R2 = 0.02, p < .01). The relationship between somatic symptoms and traumatic stress symptoms was partially mediated by sleep (p < .001). The relationship between traumatic stress symptoms and health functioning was fully mediated by sleep. Conclusions Although design characteristics, such as cross-sectional sampling, limit the inferences that can be drawn, these findings suggest that sleep may serve as an important mediator between traumatic stress and somatic symptoms.
[Advance in the pharmacological research on matrine].

OBJECTIVE The progress in the research on matrine was involved to provide references for the exploitation and utilization of the matrine. METHOD Pharmacological functions and mechanism were reviewed according to related experimental studies. RESULT Matrine has various pharmacological activities. CONCLUSION Matrine has extensive applied prospect and will be developed further.
Metastable phases of 2 D boron sheets on Ag ( 111 )

Two reproducible new phases of 2D boron sheets have been found on Ag(1 1 1). One of them shares the identical atomic structure of the previously reported S1 phase (β12 sheet) but has a different rotational relationship with the substrate, and thus exhibits very different features in scanning tunneling microscopy (STM) images. The other new phase has a hexagonal symmetry and is proposed to be the long-expected α-sheet. Both of these two boron sheets are confirmed to be metallic by scanning tunneling spectroscopy.
Tissue Factor and Cancer Metastasis: The Role of Intracellular and Extracellular Signaling Pathways

Tissue factor (TF) initiates the coagulation cascade but also plays a role in cancer and metastasis. This transmembrane protein is frequently upregulated on tumor cells and cells that show metastatic behavior. Furthermore, it is a significant risk factor for hepatic metastasis in patients suffering from colon cancer. Recently, it has been shown that TF, together with its natural ligand factor VIIa, induces intracellular changes, such as signal transduction cascades, gene transcription, and protein synthesis. Moreover, TF:factor VIIa interaction leads to survival of cells that have been stimulated to undergo apoptosis. Together with TF-dependent processes such as angiogenesis, these intracellular phenomena form a plausible explanation for the influence of TF on metastasis. In this review, we will discuss these phenomena in more detail and hypothesize on their role in TF-driven metastasis.
Bag-of-Words and Object-Based Classification for Cloud Extraction From Satellite Imagery

Automatic cloud extraction from satellite imagery is an important task for many applications in remote sensing. Humans can easily identify various clouds from satellite images based on the visual features of cloud. In this study, a method of automatic cloud detection is proposed based on object classification of image features. An image is first segmented into superpixels so that the descriptor of each superpixel can be computed to form a feature vector for classification. The support vector machine algorithm is then applied to discriminate cloud and noncloud regions. Thereafter, the GrabCut algorithm is used to extract more accurate cloud regions. The key of the method is to deal with the highly varying patterns of clouds. The bag-of-words (BOW) model is used to construct the compact feature vectors from densely extracted local features, such as dense scale-invariant feature transform (SIFT). The algorithm is tested using 101 RapidEye and 86 Landsat images with many cloud patterns. These images achieve 89.2% of precision, 87.8% of recall for RapidEye, 85.8% of precision, and 83.9% of recall for Landsat. The experiments show that the method is insensitive to the number of codewords in the codebook construction of the BOW.
Comparative analysis of adherence, viability, proliferation and morphology of umbilical cord tissue-derived mesenchymal stem cells seeded on different titanium-coated expanded polytetrafluoroethylene scaffolds

Umbilical cord tissue comprises an attractive new source for mesenchymal stem cells. Umbilical cord tissue-derived mesenchymal stem cells (UCMSC) exhibit self-renewal, multipotency and immunological naivity, and they can be obtained without medical intervention. The transfer of UCMSC to the ischemic region of the heart may have a favorable impact on tissue regeneration. Benefit from typical cell delivery by injection to the infarcted area is often limited due to poor cell retention and survival. Another route of administration is to use populated scaffolds implanted into the infarcted zone. In this paper, the seeding efficiency of UCMSC on uncoated and titanium-coated expanded polytetrafluoroethylene (ePTFE) scaffolds with different surface structures was determined. Dualmesh® (DM) offers a corduroy-like surface in contrast to the comparatively planar surface of cardiovascular patch (CVP). The investigation of adherence, viability and proliferation of UCMSC demonstrates that titanium-coated scaffolds are superior to uncoated scaffolds, independent of the surface structure. Microscopic images reveal spherical UCMSC seeded on uncoated scaffolds. In contrast, UCMSC on titanium-coated scaffolds display their characteristic spindle-shaped morphology and a homogeneous coverage of CVP. In summary, titanium coating of clinically approved CVP enhances the retention of UCMSC and thus offers a potential cell delivery system for the repair of the damaged myocardium.
Dune field pattern formation and recent transporting winds in the Olympia Undae Dune Field, north polar region of Mars

High-Resolution Imaging Science Experiment (HiRISE) imagery of the central Olympia Undae Dune Field in the north polar region of Mars shows a reticulate dune pattern consisting of two sets of nearly orthogonal dune crestlines, with apparent slipfaces on the primary crests, ubiquitous wind ripples, areas of coarse-grained wind ripples, and deflated interdune areas. Geomorphic evidence and dune field pattern analysis of dune crest length, spacing, defect density, and orientation indicates that the pattern is complex, representing two constructional generations of dunes. The oldest and best-organized generation forms the primary crestlines and is transverse to circumpolar easterly winds. Gross bed form-normal analysis of the younger pattern of crestlines indicates that it emerged with both circumpolar easterly winds and NE winds and is reworking the older pattern. Mapping of secondary flow fields over the dunes indicates that the most recent transporting winds were from the NE. The younger pattern appears to represent an influx of sediment to the dune field associated with the development of the Olympia Cavi reentrant, with NE katabatic winds channeling through the reentrant. A model of the pattern reformation based upon the reconstructed primary winds and resulting secondary flow fields shows that the development of the secondary pattern is controlled by the boundary condition of the older dune topography.
The target effect: Visual memory for unnamed search targets

Search targets are typically remembered much better than other objects even when they are viewed for less time. However, targets have two advantages that other objects in search displays do not have: They are identified categorically before the search, and finding them represents the goal of the search task. The current research investigated the contributions of both of these types of information to the long-term visual memory representations of search targets. Participants completed either a predefined search or a unique-object search in which targets were not defined with specific categorical labels before searching. Subsequent memory results indicated that search target memory was better than distractor memory even following ambiguously defined searches and when the distractors were viewed significantly longer. Superior target memory appears to result from a qualitatively different representation from those of distractor objects, indicating that decision processes influence visual memory.
Containment of Bioaerosol Infection Risk by the Xpert MTB/RIF Assay and Its Applicability to Point-of-Care Settings

ABSTRACT The recently introduced Xpert MTB/RIF assay (Xpert) has point-of-care potential, but its capacity for biohazard containment remained to be studied. We compared the bioaerosols generated by the Xpert assay to acid-fast bacillus (AFB) microscope slide smear preparation. The Xpert assay sample treatment reagent (SR) was also studied for its sterilizing capacity, stability, and effect on assay sensitivity after prolonged treatment. During the preparation of AFB smears, sputum samples spiked with Mycobacterium bovis BCG at 5 × 108 CFU/ml produced 16 and 325 CFU/m3 air measured with an Andersen impactor or BioSampler, respectively. In contrast, neither the sample preparation steps for the Xpert assay nor its automated processing produced any culturable bioaerosols. In testing of SR sterilizing capacity, clinical sputum samples from strongly smear-positive tuberculosis patients treated with SR at a 2:1 ratio eliminated Mycobacterium tuberculosis growth in all but 1/39 or 3/45 samples cultured on solid or liquid medium, respectively. These few unsterilized samples had a mean 13.1-day delay in the time to positive culture. SR treatment at a 3:1 ratio eliminated growth in all samples. SR retained a greater than 6-log-unit killing capacity despite storage at temperatures spanning 4 to 45°C for at least 3 months. The effect of prolonged SR sample treatment was also studied. Spiked sputum samples could be incubated in SR for up to 3 days without affecting Xpert sensitivity for M. tuberculosis detection and up to 8 h without affecting specificity for rifampin resistance detection. These results suggest that benchtop use of the Xpert MTB/RIF assay limits infection risk to the user.
Effects of alkyl chain length of gallate on self-association and membrane binding

Abstract Alkyl gallates are anticipated for their use as anti-bacterial and anti-viral agents. Although their pharmacological activities depend on their alkyl chain length, no mechanism has yet been clarified. As described herein, we investigated the membrane binding properties of a series of alkyl gallates using fluorescence measurement to elucidate their different pharmacological activities. Membrane binding of the alkyl gallates increased concomitantly with increasing alkyl chain length, except for cetyl gallate and stearyl gallate. Dynamic light scattering revealed that alkyl gallates with a long alkyl chain are prone to self-association in the solution. Membrane binding abilities of the alkyl gallates are correlated with anti-bacterial and anti-virus activities, as described in previous reports. The partition constants of the alkyl gallates to lipid membranes depend on the membrane components and the membrane phase. Self-association and lipid binding of the alkyl gallates might be primary biophysical factors associated with their pharmacological activities.
Functional Metaplasticity of Hippocampal Schaffer Collateral-CA1 Synapses Is Reversed in Chronically Epileptic Rats

Spatial learning and associating spatial information with individual experience are crucial for rodents and higher mammals. Hence, studying the cellular and molecular cascades involved in the key mechanism of information storage in the brain, synaptic plasticity, has led to enormous knowledge in this field. A major open question applies to the interdependence between synaptic plasticity and its behavioral correlates. In this context, it has become clear that behavioral aspects may impact subsequent synaptic plasticity, a phenomenon termed behavioral metaplasticity. Here, we trained control and pilocarpine-treated chronically epileptic rats of two different age groups (adolescent and adult) in a spatial memory task and subsequently tested long-term potentiation (LTP) in vitro at Schaffer collateral—CA1 synapses. As expected, memory acquisition in the behavioral task was significantly impaired both in pilocarpine-treated animals and in adult controls. Accordingly, these groups, without being tested in the behavioral training task, showed reduced CA1-LTP levels compared to untrained young controls. Spatial memory training significantly reduced subsequent CA1-LTP in vitro in the adolescent control group yet enhanced CA1-LTP in the adult pilocarpine-treated group. Such training in the adolescent pilocarpine-treated and adult control groups resulted in intermediate changes. Our study demonstrates age-dependent functional metaplasticity following a spatial memory training task and its reversal under pathological conditions.
Transparent Ferroelectric Capacitors on Glass

We deposited transparent ferroelectric lead zirconate titanate thin films on fused silica and contacted them via Al-doped zinc oxide (AZO) transparent electrodes with an interdigitated electrode (IDE) design. These layers, together with a TiO2 buffer layer on the fused silica substrate, are highly transparent (>60% in the visible optical range). Fully crystallized Pb(Zr0.52Ti0.48)O3 (PZT) films are dielectrically functional and exhibit a typical ferroelectric polarization loop with a remanent polarization of 15 μC/cm2. The permittivity value of 650, obtained with IDE AZO electrodes is equivalent to the one measured with Pt electrodes patterned with the same design, which proves the high quality of the developed transparent structures.
THE HOST GALAXIES OF MICRO-JANSKY RADIO SOURCES

We combine a deep 0.5 deg2, 1.4 GHz deep radio survey in the Lockman Hole with infrared and optical data in the same field, including the Spitzer Extragalactic Representative Volume Survey (SERVS) and UKIDSS near-infrared surveys, to make the largest study to date of the host galaxies of radio sources with typical radio flux densities ∼ 50 ? > μJy. 87% (1274/1467) of radio sources have identifications in SERVS to AB ≈ 23.1 ? > at 3.6 or 4. 5μm, and 9% are blended with bright objects (mostly stars), leaving only 4% (59 objects), which are too faint to confidently identify in the near-infrared. We are able to estimate photometric redshifts for 68% of the radio sources. We use mid-infrared diagnostics to show that the source population consists of a mixture of star-forming galaxies, rapidly accreting (cold mode) active galactic nuclei (AGNs) and low accretion rate (hot mode) AGNs, with neither AGNs nor star-forming galaxies clearly dominating. We see the breakdown in the K–z relation in faint radio source samples, and show that it is due to radio source populations becoming dominated by sources with radio luminosities ∼ 10 23 WHz − 1 ? > . At these luminosities, both the star-forming galaxies and the cold mode AGNs have hosts with stellar luminosities of about a factor of two lower than those of hot mode AGNs, which continue to reside in only the most massive hosts. We show that out to at least z ∼ 2 ? > , galaxies with stellar masses > 10 11.5 M ⊙ ? > have radio-loud fractions up to ∼30%. This is consistent with there being a sufficient number of radio sources for radio-mode feedback to play a role in galaxy evolution.
Crystal Growth and Scintillation Properties of 2-Inch-Diameter ${\rm Pr}:{\rm Lu}_{3}{\rm Al}_{5} {\rm O} _{12}$  (Pr:LuAG) Single Crystal

In this work we tried to grow 2-inch-diameter and high quality Pr:LuAG single crystals by the Czochralski (Cz) method. To grow the large diameter Pr:LuAG single crystal, we have optimized growth conditions and the furnace design. As a result, we have succeeded in the growth of 2-inch-diameter Pr:LuAG single crystal with a length of 110 mm. To determine light yield and energy resolution the energy spectra were collected under 662 keV gamma-ray excitation (137Cs source) and detection by a photomultiplier (Hamamatsu H7826). The light yield was around three times higher than that of BGO and almost homogeneous with increasing solidification fraction up to 0.32. The energy resolution was around 8%. Furthermore, scintillation decay time was around 23 ns and almost homogeneous all over the crystal.