Miracle-dz/UniFAR-FTUs huggingface dataset:
The Utilization of Cell-Penetrating Peptides in the Intracellular Delivery of Viral Nanoparticles

Viral particles (VPs) have evolved so as to efficiently enter target cells and to deliver their genetic material. The current state of knowledge allows us to use VPs in the field of biomedicine as nanoparticles that are safe, easy to manipulate, inherently biocompatible, biodegradable, and capable of transporting various cargoes into specific cells. Despite the fact that these virus-based nanoparticles constitute the most common vectors used in clinical practice, the need remains for further improvement in this area. The aim of this review is to discuss the potential for enhancing the efficiency and versatility of VPs via their functionalization with cell-penetrating peptides (CPPs), short peptides that are able to translocate across cellular membranes and to transport various substances with them. The review provides and describes various examples of and means of exploitation of CPPs in order to enhance the delivery of VPs into permissive cells and/or to allow them to enter a broad range of cell types. Moreover, it is possible that CPPs are capable of changing the immunogenic properties of VPs, which could lead to an improvement in their clinical application. The review also discusses strategies aimed at the modification of VPs by CPPs so as to create a useful cargo delivery tool.
Exploring Community Mobilization in Northern Quebec: Motivators, Challenges, and Resilience in Action

Abstract Nunavimmiut (people of the land) are the Indigenous peoples of the northern peninsula of the province of Quebec. Communities of Nunavik and its regional organizations have been making concerted efforts in implementing community‐based strategies to support family wellbeing. These community strategies are grounded in many of the values underpinning community psychology: favoring empowerment‐oriented approaches, fostering community capacity, and transforming organizational cultures to allow for new modes of interaction, as well as new policies and practices that are grounded in community and culture. Despite the growing support and expectation for community mobilization, there is still very little research on the processes and challenges to such mobilization. In this study, we explored the unique challenges and facilitators to community endeavors in northern Quebec in order to better understand the complex dynamics and the strengths that Inuit build upon. We first used a focused ethnographic approach in the context of a 5‐year community mobilization project in Nunavik. We then conducted 12 individual interviews and two small group interviews with Inuit working on community‐based wellbeing‐oriented mobilization projects in four additional communities. Results expose how sociogeographical realities and colonialism influence the process of community mobilization. They also highlight the values and motivational factors that lead community members to move beyond these influences.
What drives female objectification? An investigation of appearance-based interpersonal perceptions and the objectification of women

Previous research finds that both men and women perceive sexualized women as lacking in certain human qualities such as mental capacity and moral status. The mechanism underlying this effect, however, is unclear. The present two studies test how appearance-based judgements affect the degree to which a broad sample of women are objectified. In Study 1 (N = 279), full-body images of women wearing different clothing outfits were rated by male and female participants on perceived attractiveness, sexual intent and age. In Study 2, male and female participants (N = 1,695) viewed these same images from Study 1 and rated them on two dimensions of objectification (agency and patiency). We analyzed associations between these dimensions of objectification and the averaged appearance-based perceptions from Study 1. We find that women perceived as more open to casual sex are attributed less mental capacity and less moral status. We also find that participants tend to associate attractiveness with greater mental and moral status in women, but we find only limited evidence that perceived age influences objectification. Our findings suggest that although positive attractiveness biases may mitigate the amount a woman is objectified, greater female objectification may be prompted by observers’ negative stereotypes of promiscuous women.
Characterizing symptoms of traumatic brain injury in survivors of intimate partner violence

ABSTRACT Objective: This study examined the extent symptoms associated with potential traumatic brain injury (TBI) in intimate partner violence (IPV) survivors overlap with sport-related concussions (SRC). IPV survivor responses on the Brain Injury Severity Assessment (BISA) tool, an IPV-specific questionnaire developed to assess TBI symptoms; and the widely-used Sport Concussion Assessment Tool (SCAT5), were compared. Additionally, psychopathological assessments of post-traumatic stress disorder (PTSD), depression, and anxiety were completed to account for confounding influences. Design: Eighteen women who had experienced IPV were recruited from high-barrier community-based women’s shelters. Results: The total number of reported TBI were higher when employing the BISA compared to SCAT5, the strongest symptom-based correlations associated TBI severity was associated with arousal states (“Fatigue”, “Anxious”, “Drowsiness”, “Just Don’t Feel Right”) or aspects of memory/cognition (“Difficulty Concentrating”, “Difficulty Remembering”). Furthermore, TBI severity was also related to the degree of depression and anxiety, but unrelated to PTSD. Conclusions: Taken together, these findings can contribute to the development of enhanced screening tools and supports to help front-line staff identify TBI as a possible contributor to challenges faced by IPV survivors. By this means, women who have experienced IPV will be more likely to break the cycle of abuse and have more positive long-term health outcomes
HFE Related Hemochromatosis: Uncovering the Inextricable Link between Iron Homeostasis and the Immunological System

The HFE gene (OMIM 235200), most commonly associated with the genetic iron overload disorder Hemochromatosis, was identified by Feder et al. in 1996, as a major histocompatibilty complex (MHC) class I like gene, first designated human leukocyte antigen-H (HLA-H). This discovery was thus accomplished 20 years after the realization of the first link between the then “idiopathic” hemochromatosis and the human leukocyte antigens (HLA). The availability of a good genetic marker in subjects homozygous for the C282Y variant in HFE (hereditary Fe), the reliability in serum markers such as transferrin saturation and serum ferritin, plus the establishment of noninvasive methods for the estimation of hepatic iron overload, all transformed hemochromatosis into a unique age related disease where prevention became the major goal. We were challenged by the finding of iron overload in a 9-year-old boy homozygous for the C282Y HFE variant, with two brothers aged 11 and 5 also homozygous for the mutation. We report a 20 year follow-up during which the three boys were seen yearly with serial determinations of iron parameters and lymphocyte counts. This paper is divided in three sections: Learning, applying, and questioning. The result is the illustration of hemochromatosis as an age related disease in the transition from childhood to adult life and the confirmation of the inextricable link between iron overload and the cells of the immune system.
Equine digital tendons show breed specific differences in their mechanical properties that may relate to athletic ability and predisposition to injury.

BACKGROUND Throughout the ages, humans have selected horse breeds for their locomotor capacities. Concurrently, tissue properties may have diversified because of specific requirements of different disciplines. OBJECTIVES The aim of this study was to compare the biomechanical properties of tendons with different functions between equine breeds traditionally selected for racing or sport. STUDY DESIGN This study used ex vivo tendons and compared the mechanical properties of the common digital extensor tendon (CDET) and superficial digital flexor tendon (SDFT) between racehorses (Thoroughbred [TB]) and sports horses (Friesian Horse [FH], Warmblood [WB]). METHODS The SDFT and CDET of FH (n = 12), WBs (n = 12) and TBs (n = 8) aged 3-12 years were harvested. The cross sectional area (cm2 ), maximal load (N), ultimate strain (%), ultimate stress (MPa), and elastic modulus (MPa) were determined and tested for significant differences between the breeds (P<0.05). RESULTS The SDFT from WB horses had a significantly lower elastic modulus than TB horses and failed at a higher strain and load than both FHs and TBs. The mechanical properties of the CDET did not differ between breeds. In agreement with previous studies, the CDET failed at a higher stress and had a higher elastic modulus than the SDFT and, for the WB group of horses only, failed at a significantly lower strain. Interestingly, the mode of failure differed between breeds, particularly with respect to the FHs. MAIN LIMITATIONS The exercise history of horses used in this study was unknown and the age-range was relatively large; both these factors may have influenced the absolute properties reported in this study. CONCLUSIONS This study shows for the first time that mechanical properties of the SDFT differ between breeds. These properties are likely to be related to selection for high-speed versus an extravagant elastic gait and may be an important indicator of performance ability. This article is protected by copyright. All rights reserved.
Evaluation of Policies on Inappropriate Treatment of Dead Hogs from the Perspective of Loss Aversion

Punishment policies on the inappropriate treatment of dead hogs play a key role in safeguarding public health and environmental protection. These policies aim to regulate the behavior of farmers and promote the development of sustainable agriculture. Farmers’ evaluation of a policy can be used to measure its effectiveness, and loss aversion is a factor that has been little studied. This study surveyed 404 hog farmers in China, and analyzed the factors that influenced their evaluation of the penalties for the inappropriate treatment of dead hogs during 2016 and 2017. We used three indicators for the evaluation of the penalties: the degree of necessity, implementation, and effectiveness. Special attention was paid to farmers’ aversion to financial penalties and police detention time, which was elicited using economic experiments. The results show that farmers are more likely to be averse to police detention time than financial penalties, and suggest that the level of each indicator needs to be increased. The results from an ordered Probit model show that there are both similarities and differences between the formation paths of the three indicators. An aversion to financial penalties will help to improve the degree of implementation. An aversion to police detention time will lead to a negative trend in the degree of effectiveness. An in-depth analysis of the factors that influence farmers’ evaluation of policies to punish inappropriate treatment of dead hogs may provide a basis for the design of government policies to improve environmental protection performance.
Behavioural, physiological and molecular changes in alloparental caregivers may be responsible for selection response for female reproductive investment in honey bees

Reproductive investment is a central life history variable that influences all aspects of life. Hormones coordinate reproduction in multicellular organisms, but the mechanisms controlling the collective reproductive investment of social insects are largely unexplored. One important aspect of honey bee (Apis mellifera) reproductive investment consists of raising female‐destined larvae into new queens by alloparental care of nurse bees in form of royal jelly provisioning. Artificial selection for commercial royal jelly production over 40 years has increased this reproductive investment by an order of magnitude. In a cross‐fostering experiment, we establish that this shift in social phenotype is caused by nurse bees. We find no evidence for changes in larval signalling. Instead, the antennae of the nurse bees of the selected stock are more responsive to brood pheromones than control bees. Correspondingly, the selected royal jelly bee nurses are more attracted to brood pheromones than unselected control nurses. Comparative proteomics of the antennae from the selected and unselected stocks indicate putative molecular mechanisms, primarily changes in chemosensation and energy metabolism. We report expression differences of several candidate genes that correlate with the differences in reproductive investment. The functional relevance of these genes is supported by demonstrating that the corresponding proteins can competitively bind one previously described and one newly discovered brood pheromone. Thus, we suggest several chemosensory genes, most prominently OBP16 and CSP4, as candidate mechanisms controlling queen rearing, a key reproductive investment, in honey bees. These findings reveal novel aspects of pheromonal communication in honey bees and explain how sensory changes affect communication and lead to a drastic shift in colony‐level resource allocation to sexual reproduction. Thus, pheromonal and hormonal communication may play similar roles for reproductive investment in superorganisms and multicellular organisms, respectively.
Relationship between sense of coherence, health status, and work engagement among nurses.

AIM To examine the sense of coherence (SOC) among registered nurses and its relationship with health and work engagement. BACKGROUND SOC is a global orientation to view life as structured, manageable, and meaningful and have the capacity to cope with stressful situations. A high SOC score indicates that an individual can understand, manage, and attribute meaning to events in his or her life as well as in the work environment. Registered nurses face many workplace stressors that may be easier to manage with a strong SOC; however, the effect of this score on their self-reported health status and work engagement remains unknown. METHODS In a cross-sectional study, 109 registered nurses working in a long-term care setting responded to a self-administered questionnaire. Social support, work-related family conflicts, SOC, self-reported health status, and work engagement variables were analysed using multiple linear regression models. RESULTS Nurses with a high SOC score reported no work-related family conflicts (mean difference -6.91; 95% CI -10.65 to -3.18; p = 0.000), better health (r =0.408), and greater work engagement (r =0.223), compared to their peers with lower SOC. The association between SOC and self-reported health was confirmed by linear regression modelling (β = 0.276, p = 0.003). CONCLUSIONS Nurses with a higher SOC had better health and greater work engagement. The work engagement variable showing the highest association with SOC was dedication. IMPLICATIONS FOR NURSING MANAGEMENT Implementing interventions that increase SOC among nurses can increase commitment to their work, to the institution, and to building more engaged teams.
Chk1 Inhibitor MK-8776 Restores the Sensitivity of Chemotherapeutics in P-glycoprotein Overexpressing Cancer Cells

P-glycoprotein (P-gp), which is encoded by the ATP-binding cassette (ABC) transporter subfamily B member 1 (ABCB1) gene, is one of the most pivotal ABC transporters that transport its substrates across the cell membrane. Its overexpression is one of the confirmed causes of multidrug resistance (MDR), which results in the failure of cancer treatment. Here, we report that checkpoint kinase (Chk) 1 inhibitor MK-8776, a drug candidate in clinical trial, can restore the sensitivity of chemotherapeutics that are substrates of P-gp in KB-C2, SW620/Ad300 cells and human embryonic kidney (HEK)293/ABCB1 cells that overexpress P-gp. MK-8776 remarkably enhanced the cellular [3H]-paclitaxel accumulation and suppressed the efflux function of P-gp without reducing its expression and affecting its cellular localization in cancer cells. Furthermore, MK-8776 (0–40 μM) stimulated the activity of ATPase in P-gp, which was 4.1-fold greater than the control. In addition, MK-8776 formed a cation–π bond and π–π interaction with key residues of the substrate-binding site in P-gp, as indicated by computer-aided molecular docking study. Our study indicated that MK-8776 may significantly enhance the sensitivity of chemotherapeutics that are substrates of P-gp, providing important information for its application in the reversal of MDR.
Synthesis of Electrocardiogram V-Lead Signals From Limb-Lead Measurement Using R-Peak Aligned Generative Adversarial Network

Recently, portable electrocardiogram (ECG) hardware devices have been developed using limb-lead measurements. However, portable ECGs provide insufficient ECG information because of limitations in the number of leads and measurement positions. Therefore, in this study, V-lead ECG signals were synthesized from limb leads using an R-peak aligned generative adversarial network (GAN). The data used the Physikalisch-Technische Bundesanstalt (PTB) dataset provided by PhysioNet. First, R-peak alignment was performed to maintain the physiological information of the ECG. Second, time domain ECG was converted to bi-dimensional space by ordered time-sequence embedding. Finally, the GAN was learned through the pairs between the modified limb II (MLII) lead and each chest (V) lead. The result showed that the mean structural similarity index (SSIM) was 0.92, and the mean error rate of the percent mean square difference (PRD) of the chest leads was 7.21%.
Classification of position management strategies at the order-book level and their influences on future market-price formation

Financial prices fluctuate as a results of the market impact of the flow of transactions between traders. Reciprocally, several studies of market microstructure have shown how decisions of individual traders or banks, implemented in their trading strategies, are affected by historical market information. However, little is known about the detailed processes of how such trading strategies at the micro level recursively affect future market information at the macro level. Using a special fined-grained dataset that allows us to track the complete trading behavior of specific banks in a U.S. dollar (USD) versus Japanese yen (JPY) market, we find that position management methods, defined as the number of units of USD bought or sold by banks against JPY, can be classified into two strategies: (1) banks increase their positions by trading in the same direction repeatedly, or (2) banks attempt to reduce their inventories by rapidly shifting their positions toward zero. We then demonstrate that their systematic position management strategies strongly influence future market prices, as demonstrated by our ability using this information to predict market prices about fifteen minutes in advance. Further, by detecting outlier trades, we reveal that traders seem to switch their strategies when they become aware of outlier trades. The evidence obtained here suggests that positions, which are a consequence of historical trading decisions based on the position management strategies of each bank, strongly influence future market prices, and we unravel how market prices at the macro level evolve through an interactive process involving the interaction between well-defined trading strategies at the micro level.
Secular Trends in Incidence, Modality, and Mortality with Dialysis Receiving AKI in Children in Ontario: A Population-Based Cohort Study.

BACKGROUND AND OBJECTIVES There is a limited appreciation of the epidemiology of dialysis-receiving AKI in children. The primary objective of the study was to evaluate changes in the incidence of dialysis-receiving AKI among children over a period of 20 years in Ontario, Canada. The secondary objectives were to assess temporal trends in the utilization of various dialysis modalities and 30-day mortality among children with dialysis-receiving AKI. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS All children (29 days to 18 years) who received their first dialysis for AKI between 1996 and 2015 were identified from healthcare administrative databases. Those who received dialysis for ESKD, inborn errors of metabolism, and poisonings were excluded. The incidence rates of dialysis-receiving AKI were reported annually. The Cochran-Armitage test was used to assess trends in the incidence and short-term mortality after dialysis-receiving AKI. RESULTS We identified 1394 children treated with dialysis for AKI during a hospital stay. There was a significant increase in the incidence of dialysis-receiving AKI among hospitalized children from 1996 (0.58 per 1000 person-years) to 2015 (0.65 per 1000 person-years) (P=0.01). The use of continuous kidney replacement therapy and intermittent hemodialysis increased whereas the relative use of peritoneal dialysis declined over time. Thirty-day mortality rates after dialysis-receiving AKI increased from 14% to 25% between 1996 and 2009 and reduced to 19% in the more recent years (P=0.03). CONCLUSIONS In Ontario, the incidence of dialysis-receiving AKI among children has increased between 1996 and 2015. The use of peritoneal dialysis for AKI has declined and the short-term mortality after dialysis-receiving AKI has increased. PODCAST This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2019_08_23_CJN08250718. mp3.
Nostalgia Proneness and Empathy: Generality, Underlying Mechanism, and Implications for Prosocial Behavior.

OBJECTIVE Nostalgia is a sentimental longing for one's past. We examined the hypotheses (rooted in attachment theory and research) that nostalgia prone individuals, by virtue of their greater attachment security, are more empathic and enact more prosocial behavior. METHOD In five studies, testing 1923 participants (Nrange = 132-823, 52.42% women, Agerange = 8-90 years), we measured nostalgia proneness and affective empathy. Additionally, we measured cognitive empathy in Study 3, attachment security in Studies 4-5, and prosocial behavior in Study 5. RESULTS Nostalgia proneness was positively related to affective empathy among younger and older adults (Studies 1, 3-5) and among children (Study 2). This association was stronger for affective empathy than cognitive empathy (Study 3). Also, attachment security mediated the relation between nostalgia proneness and affective empathy (Studies 4-5). Finally, nostalgia prone individuals were more likely to engage in prosocial behavior, and this relation was serially mediated by attachment security and affective empathy (Study 5). CONCLUSION The findings establish the empathic and prosocial character of nostalgia prone individuals, and clarify their personality profile.