Miracle-dz/UniFAR-FTUs huggingface dataset:
Antimutagenic and Antioxidant Characteristics of Chukrasia tabularis A Juss Extracts

The current study aims to evaluate the antioxidative and antimutagenic activities of methanol extract and different fractions of Chukrasia tabularis leaves. The antioxidative potential was evaluated using 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation and superoxide anion radical-scavenging assay. The antimutagenic potential was evaluated against direct-acting mutagens, 4-nitro-o-phenylenediamine and sodium azide; and S9-dependent mutagen, 2-aminofluorene in TA98 and TA100 strains of Salmonella typhimurium using Ames assay. It has been found that methanol extract and its fractions were more efficient against S9-dependent mutagen in pre-incubation mode of treatment as compared to direct-acting mutagens in both the strains. Methanol extract and its fractions also exhibited strong radical-scavenging potential. High-performance liquid chromatography (HPLC) analysis of methanol extract showed the presence of gallic acid, epicatechin, 7-hydroxycoumarin, and rutin. From the study, it could be concluded that antioxidative and antimutagenic activity of methanol extract and its fractions was related to the synergistic interactions among different chemical compounds.
Inversion with regularization for the retrieval of tropospheric aerosol parameters from multiwavelength lidar sounding.

We present an inversion algorithm for the retrieval of particle size distribution parameters, i.e., mean (effective) radius, number, surface area, and volume concentration, and complex refractive index from multiwavelength lidar data. In contrast to the classical Tikhonov method, which accepts only that solution for which the discrepancy reaches its global minimum, in our algorithm we perform the averaging of solutions in the vicinity of this minimum. This averaging stabilizes the underlying ill-posed inverse problem, particularly with respect to the retrieval of number concentration. Results show that, for typical tropospheric particles and 10% error in the optical data, the mean radius could be retrieved to better than 20% from a lidar on the basis of a Nd:YAG laser, which provides a combination of backscatter coefficients at 355, 532, and 1064 nm and extinction coefficients at 355 and 532 nm. The accuracy is improved if the lidar is also equipped with a hydrogen Raman shifter. In this case two additional backscatter coefficients at 416 and 683 nm are available. The combination of two extinction coefficients and five backscatter coefficients then allows one to retrieve not only averaged aerosol parameters but also the size distribution function. There was acceptable agreement between physical particle properties obtained from the evaluation of multiwavelength lidar data taken during the Lindenberg Aerosol Characterization Experiment in 1998 (LACE 98) and in situ data, which were taken aboard aircraft.
Naturally Occurring Human IgM Antibody That Binds B7-DC and Potentiates T Cell Stimulation by Dendritic Cells 1

A human IgM Ab, serum-derived human IgM 12 (sHIgM12), is identified that binds mouse and human dendritic cells (DC), inducing dramatic immunopotentiation following treatment of the mouse DC in vitro. Competition, transfection, and knockout studies identified the ligand on mouse DC as the costimulatory molecule family member B7-DC. Potent T cell responses are stimulated by Ag-pulsed DC treated with the sHIgM12 Ab in vitro and upon adoptive transfer of Ab-treated Ag-pulsed DC into animals. The multivalent structure of pentameric IgM provides the potential for cross-linking cell surface targets, endowing the soluble Abs with biological potential not normally associated with immune function. The ability of the sHIgM12 Ab to potentiate the immune response is dependent on the multimeric structure of IgM, as bivalent monomers do not retain this property. Furthermore, pretreatment of DC with IgM monomers blocks subsequent potentiation by intact IgM pentamers, an indication that cross-linking of B7-DC on the cell surface is critical for potentiation of Ag presentation. These findings imply that, in addition to known costimulatory roles, B7-DC can function as a receptor for signals delivered by cells expressing B7-DC ligands.
Intravitreal Injection of Commercially Available Ketorolac Tromethamine in Eyes with Diabetic Macular Edema Refractory to Laser Photocoagulation

Purpose: To evaluate the short-term effect of a single intravitreal injection of commercially available ketorolac tromethamine (KT) in eyes with diabetic macular edema refractory to laser photocoagulation. Methods: Prospective interventional case series. Twenty five patients with diabetic macular edema refractory to laser photocoagulation received a single intravitreal injection of commercially available KT (Toradol®), in a dose of 3000 µg. Examination included assessment of ETDRS-best corrected visual acuity (BCVA), measurement of intraocular pressure and high resolution imaging by optical coherence tomography, preoperatively and 7, 15, and 30 days postoperatively. Results: In the follow up visits at 7, 15 and 30 days, BCVA had improved five or more letters in 20% (95% confidence interval, 7.7–38.9%), 16% (95% confidence interval, 5.3–34.2%) and 28% (95% confidence interval, 13.2–47.7%) respectively. An improvement in macular thickness was also observed, although it has not been statistically significant. Conclusion: This pilot study showed that a single intravitreal injection of 3000 µg of commercial KT led to a short-term improvement of visual acuity in approximately 30% of eyes with diabetic macular edema refractory to laser photocoagulation.
Multi-objective Optimization of Passive Shock Absorber for Landing Gear

In previous paper, “Multi-objective optimization of Passive Shock Absorber for Landing Gear”, several new construction of metering pin in passive shock absorber have been proposed, and obtained optimum solutions of metering pin dimensions by multi-objective optimization. The aim of the previous paper is to solve the mass variation problem. The shock absorbers with the results of multi-objective optimization for the new metering pin constructions can be called a “semi semi-active shock absorber”. In this paper, we do single-objective optimization just for simple passive shock absorbers, namely optimization at maximum or minimum masses. The aim of this paper is to evaluate the performance of simple passive shock absorbers with new construction metering pin, not as a semi semi-active shock absorber to deal with the mass variation problem. We proposed single-objective optimization method of passive shock absorber without metering pin, with single and multi-tapered metering pins, and with single and multi-parabolic metering pins. Each of these metering pin constructions have been obtained optimal solutions. Using the optimum solutions, we evaluate and compare the performance of each passive shock absorber without and with different metering pins for maximum or minimum masses. The optimization results and method are helpful in the design of landing gears for various aircrafts, especially, for design of lighter aircraft landing gears, not necessary to be considered mass vibration problem.
Prescription of psychotropic medications to youths in office-based practice.

OBJECTIVE This study sought to determine sociodemographic characteristics of treatment of children and adolescents for whom psychotropic medications are prescribed and to describe the clinical management approaches associated with the prescription of each major class of psychotropic medication in office-based medical practices in the United States. METHODS Data for a four-year period (1992-1996) were drawn from the National Ambulatory Medical Care Survey, a nationally representative survey of office-based medical practices, to determine prescribing patterns, patients' sociodemographic characteristics, and clinical management approaches associated with visits during which psychotropic medications were prescribed to patients aged 19 years or under. RESULTS Psychotropic medications were prescribed during 2.2 percent of all visits. A majority of the prescriptions for psychotropic medications (84.8 percent) were provided by general practitioners or pediatricians. For the visits during which a psychotropic medication was prescribed, stimulants were the most commonly prescribed (53.9 percent of such visits), but prescription of other classes of medications was not uncommon: antidepressants (30 percent), anxiolytics (7.2 percent), antipsychotics (7.2 percent), and mood stabilizers (12.7 percent). Significant differences were observed in the prescription of each class of medication by sex, race, and payment source. CONCLUSIONS General practitioners and pediatricians have a role in the office-based treatment of youths with psychotropic medications.
GENOME A NNOUNCEMENT - Pathogens & Pathogenicity Draft genome sequence of the Chilean isolate Aeromonas salmonicida strain CBA100

ABSTRACT Wereportthedraftgenomesequencefrom Aeromonas salmonicida sp.strainCBA100,whichwascharacterizedasanantibiotic-resistantbacteriumisolatedfrominfectedrainbowtrout.Thetotalsizeofthegenomeis4788109bp,withaG+Ccontentof60.55%. ComparisonofitsopenreadingframesshowsthattheclosesthomologuetoonethirdofthegenesofstrainCBA100arefoundin A. hydrophila . Thestraincontainsseveraleffluxpumpsandputativegenesthatconferresistancetomulticlassantibiotics,includingmacrolide, β -lactamics,florfenicolandquinolones.Theantibiogramprofilesuggeststhateffluxpumpsarethemainmechanismofresistancetonon- β -lactamicantibiotics.ThisisthefirstgenomeofaChileanisolateof A. salmonicida ,whichshouldshedlightonthedesignofstrain-specificvaccinesagainstthispathogenandreducetheuseofantibioticsforpreventivetreatmentinChileanaquaculture. Key words: fishpathogen;multiresistance;vaccine INTRODUCTION Aeromonas salmonicida is an etiological agent of ulcerativedisease and furunculosis in salmonoids (Dallaire-Dufresne et al., 2014). InChile,furunculosisisthemaincauseofmortalityoccasionedbyextracellularbacteriain
Evolution of wild cereals during 28 years of global warming in Israel

Climate change is a major environmental stress threatening biodiversity and human civilization. The best hope to secure staple food for humans and animal feed by future crop improvement depends on wild progenitors. We examined 10 wild emmer wheat (Triticum dicoccoides Koern.) populations and 10 wild barley (Hordeum spontaneum K. Koch) populations in Israel, sampling them in 1980 and again in 2008, and performed phenotypic and genotypic analyses on the collected samples. We witnessed the profound adaptive changes of these wild cereals in Israel over the last 28 y in flowering time and simple sequence repeat allelic turnover. The revealed evolutionary changes imply unrealized risks present in genetic resources for crop improvement and human food production.
Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin's lymphomas dampening natural killer cell functions

Non-Hodgkin's lymphomas (NHLs) are malignant neoplasms which are clinically and biologically diverse. Their incidence is constantly increasing and despite treatment advances, there is a need for novel targeted therapies. Here, we identified Lectin-like transcript 1 (LLT1) as a biomarker of germinal center (GC)-derived B-cell NHLs. LLT1 identifies GC B cells in reactive tonsils and lymph nodes and its expression is maintained in B-cell NHLs which derive from GC, including Burkitt lymphoma (BL), follicular lymphoma (FL), and GC-derived diffuse large B-cell lymphoma (DLBCL). We further show that LLT1 expression by tumors dampens natural killer (NK) cell functions following interaction with its receptor CD161, uncovering a potential immune escape mechanism. Our results pinpoint LLT1 as a novel biomarker of GC-derived B-cell NHLs and as a candidate target for innovative immunotherapies.
Effects of laparoscopic surgery on serum anti-müllerian hormone levels in reproductive-aged women with endometrioma

A few studies have investigated the effects of laparoscopic cystectomy for endometrioma on ovarian reserve using serum anti-Müllerian hormone (AMH) levels and have shown inconsistent results. This prospective study was performed to estimate early changes in serum AMH after laparoscopic surgery for endometrioma. In 27 women aged 21–46 years who underwent laparoscopic unilateral cystectomy (n = 13) or oophorectomy (n = 14) for endometrioma, we measured pre- and postoperative serum AMH levels at baseline and 1 week, 1 month, and 3 months after surgery. Serial changes in serum AMH levels were analyzed according to the operation type using analysis of variance. Mean levels of serum AMH decreased significantly immediately after surgery and remained for up to 3 months in both operation types (P = 0.002 for cystectomy group and P <0.001 for oophorectomy group). In addition, the serum AMH levels showed similar patterns of change after cystectomy or oophorectomy. In conclusion, laparoscopic ovarian cystectomy for endometrioma appears to decrease serum AMH levels immediately after surgery.
Treatment delayed is treatment denied: The tortuous pathway to care for acute coronary syndrome

Background: Time duration between symptom onset and treatment in acute coronary syndrome (ACS) is important in determining survival outcomes. This study aimed to determine the extent of delays that occur in the pathway to seeking specific treatment among ACS patients and to explore the associated factors. Materials and Methods: This cross-sectional study was conducted in the emergency department of a tertiary care hospital in Madurai, Tamil Nadu, India, among patients with ACS. A questionnaire was used to collect information on demographic details, clinical features, time duration, and health system-related factors. The time delay at various levels was expressed as median and interquartile range (IQR). Nonparametric tests were applied to test for statistical differences in subgroups. Results: Among 232 ACS patients, the median (IQR) delay from symptom onset to decision-making was 30 min (10, 240), from decision-making to arriving at the first facility was 30 min (15, 45), and from decision-making to receiving specific treatment was 23.3 h (1, 170). Nearly 91% of the patients contacted private health facilities first and only 21.1% received any specific treatment at the first facility they contacted. The two most common reasons for referral from a lower level health facility were lack of infrastructure and lack of a specialist. Conclusions: Significant delays occurred in the pathway to receiving specific treatment for ACS, especially due to delays in decision-making and number of facilities contacted in the initial period not being able to provide specific treatment. Private health facilities are more sought after for emergency care of ACS.
Elucidating the evolution and diversity of Uroglena-like colonial flagellates (Chrysophyceae): polyphyletic origin of the morphotype

ABSTRACT The Uroglena-like morphotype represents a prototype of a colonial naked chrysophyte, comprising plastid-bearing cells that are arranged as the surface monolayer of the spherical colony. So far, insufficient molecular characterization appears to be the most significant brake on the modern taxonomic revision of this ecologically and morphologically coherent group of organisms. The general aim of this work was to conduct a modern taxonomic revision of Uroglena-like flagellates by using combined molecular, morphological and ultrastructural methodology, complemented by exploring type localities of Uroglena volvox and Uroglenopsis americana in Europe and North America, respectively. On the basis of phylogenetic analysis of concatenated nuclear SSU rDNA and plastid rbcL sequences we show that Uroglena-like colonial flagellates form three genetically and morphologically distinct lineages within the Ochromonadales (Chrysophyceae), distinguished here as Uroglena, Uroglenopsis and Urostipulosphaera gen. nov. The taxonomic status of the other chrysophyte genera with spherical colonies is discussed in light of our findings.
Attentional–inhibitory control and social–behavioral regulation after childhood closed head injury: Do biological, developmental, and recovery variables predict outcome?

Attentional–inhibitory control and social–behavioral regulation are two outcome domains commonly impaired after childhood closed head injury (CHI). We compared neuropsychological tests of attentional–inhibitory control (vigilance, selective attention, response modulation) and social discourse and intentionality (inferencing, figurative language, and speech acts) with parent ratings of attention and behavioral regulation in relation to four injury- related variables: age at CHI, time since CHI, CHI injury severity, and frontal lobe injury moderated by CHI severity. Participants were 105 school-aged children in the chronic stage of CHI, divided into mild, moderate, and severe injury severity groups, and further subdivided according to frontal lobe injury. Outcome indices were imperfectly correlated in the group as a whole, although several relations between neurocognitive tests and parent ratings were observed within CHI subgroups. Different domains of cognitive function had different predictors. For attentional–inhibitory control, age at injury and time since injury were most predictive of outcome; for social discourse, predictors were injury severity and frontal lobe injury moderated by injury severity. Variability in cognitive outcome after childhood CHI is not random, but appears related to age, time, and biological features of the injury. (JINS, 2001, 7, 683–692.)
Quantitative identification of sources of dioxin‐like polychlorinated biphenyls in sediments by a factor analysis model and a chemical mass balance model combined with monte carlo techniques

The major sources of dioxin‐like polychlorinated biphenyls (PCBs) in two sediment cores from Tokyo Bay and Lake Shinji (both in Japan) were identified and their source contributions estimated using two receptor models. The first was a nonnegative constrained factor analysis (FA) model, and the second was a nonnegative constrained chemical mass balance model combined with Monte Carlo techniques (CMB‐MC) to take into account the variability and uncertainty in both PCB congener profiles of sources and environmental samples. According to the FA model, variations in the concentrations of dioxin‐like PCBs in each sediment core were accounted for almost entirely by two factors, which were considered to correspond to Kanechlors (KCs; Japanese PCB products) and incineration. The CMB‐MC model investigated the trends of the burdens from four types of KCs and incineration to the concentrations of dioxin‐like PCBs in each sediment core. The results for both sediment cores obtained by both models indicated that the burden from KCs increased gradually beginning in the 1950s, peaked around 1970, and declined thereafter, whereas the burden from incineration increased gradually from the 1950s to the early 1990s. The estimated contribution from incineration to the toxic equivalent concentration of dioxin‐like PCBs was comparable to that from KCs.
Factors Responsible for Marital Infidelity among Ipata Market Women in Ilorin Kwara State

Marital infidelity also known as extra marital affairs is one of the commonly pronounced problem in marriage, it also include extra marital relationship, cheating and sexual intercourse. Moderating variables like family type, age, employability status and religion were considered as factors responsible for marital infidelity as perceived by women. This study investigated factors responsible for marital infidelity among Ipata market women in Ilorin south local government area, Kwara State. The descriptive survey method was adopted for the study. A total of 230 women were selected using purposive and simple random sampling techniques. An instrument titled ‘Factors Responsible for Marital Infidelity Questionnaire (FRMQ) was used to obtain data from the respondents. The data generated was analyzed using frequency counts and percentage for the demographic data while Analysis of variance (ANOVA) were used to test the three postulated hypotheses at 0.05 alpha level. The finding revealed that there is no significant difference in factor responsible for marital infidelity as perceived by women in Ilorin south local government area of Kwara State on the basis of family type. Also there is significant difference in factor responsible for marital infidelity as perceived by women in Ilorin south local government area Kwara State on the basis of age, employability status and religion. Based on the findings of the study, it was recommended that counsellors should enlightened couples on needs to engage in satisfactory sexual relationship; in addition counsellors in collaboration with health workers should enlightened couples on how to improve their sexual urge towards each other and overcome frigidity. In order to reduce the risk of marital infidelity among women, it is necessary for woman to engage in one occupation or trade and women should be encouraged not to trade their marital integrity on the platform of job security
Analyse Non Linéaire par Eléments Finis des Plaques en Béton ArméSoumises aux Explosions

Pour les structures destinees a la protection contre les effets des explosions, le beton arme est communement utilise. Les structures en beton arme soumises aux explosions auront un comportement totalement different de celui des structures sollicitees statiquement. Durant l’explosion la structure vibrera et sera soumise a des ondes de choc qui peuvent resulter en de grands endommagements pour la structure avec possibilite d’atteinte aux vies humaines. Cette these est destinee a ameliorer les connaissances concernant le comportement des plaques en beton arme soumises aux explosions. Un autre but est la description et l’utilisation de la methode des elements finis dans le domaine non lineaire par l’etude des differents parametres (materiels, numeriques et explosions) pouvant avoir un effet sur la reponse du beton arme soumis aux explosions. Une attention particuliere sera accordee au comportement dynamique car il differe en divers aspects du comportement statique. La resistance a la compression et la resistance a la traction augmentent avec la vitesse de deformation. La rigidite initiale augmente ainsi que la capacite portante du beton sous chargement dynamique. Aussi la phase negative de l’onde de choc qui est souvent negligee dans les etudes des structures en beton arme sous les explosions sera incorporee afin de quantifier sont impact eventuel sur la reponse. Pour apprendre plus sur le comportement du beton soumis a des charges severes, il serait souhaitable de combiner les techniques d’analyses non lineaires avancees avec des essais. Un veritable modele doit etre capable de capturer correctement les resultats obtenus de differents essais. Mais malheureusement, les essais coutent chers et la reproductibilite de leurs resultats n’etant pas toujours assuree, c’est pourquoi le recours aux simulations numeriques reste incontournable. Dans cette these, des analyses dynamiques non lineaires par elements finis seront entreprises et comparees lorsque c’est possible aux resultats aussi bien numeriques qu’experimentaux existants.