Miracle-dz/UniFAR-FTUs huggingface dataset:
Noncommutative harmonic analysis on semigroup and ultracontractivity

We extend some classical results of Cowling and Meda to the noncommutative setting. Let $(T_t)_{t>0}$ be a symmetric contraction semigroup on a noncommutative space $L_p(\mathcal{M}),$ and let the functions $\phi$ and $\psi$ be regularly related. We prove that the semigroup $(T_t)_{t>0}$ is $\phi$-ultracontractive, i.e. $\|T_t x\|_\infty \leq C \phi(t)^{-1} \|x\|_1$ for all $x\in L_1(\mathcal{M})$ and $ t>0$ if and only if its infinitesimal generator $L$ has the Sobolev embedding properties: $\|\psi(L)^{-\alpha} x\|_q \leq C'\|x\|_p$ for all $x\in L_p(\mathcal{M}),$ where $1<p<q<\infty$ and $\alpha =\frac{1}{p}-\frac{1}{q}. $ We establish some noncommutative spectral multiplier theorems and maximal function estimates for generator of $\phi$-ultracontractive semigroup. We also show the equivalence between $\phi$-ultracontractivity and logarithmic Sobolev inequality for some special $\phi$. Finally, we gives some results on local ultracontractivity.
Therapeutic targeting of methylthioadenosine phosphorylase

Methylthioadenosine Phosphorylase is a well-known tumor suppressor and a regulator for purine and pyrimidine synthesis and metabolism. Several previous studies show MTAP could be a prognostic marker independent or coordinate with p16 in multiple cancer types. Furthermore, inhibitors of MTAP have been developed and tested in in vitro and in vivo experiment to support the selective tumor cell-killing theory of MTAP. The review aims to provide a deep understanding of the clinical role and the metabolic reprogramming regulated by MTAP in cancer as the guide to found out and solve the problems of MTAP based cancer therapy.
The morphological typology of change of state event encoding

Words denoting non-causative and causative change of state (COS) predicates often are morphologically related to words denoting the related state predicates, though the relationship sometimes differs for different types of states. For the state of ‘brokeness’, for example, in English the word denoting the state in (1c) is derived from the words denoting the change of state. In contrast, the word denoting the state of ‘looseness’ in (2c) is morphologically basic, with the words denoting the changes of state being derived from it.
Monoclonal antibody therapies for the treatment of relapsing-remitting multiple sclerosis: differentiating mechanisms and clinical outcomes

Monoclonal antibody (mAb) therapies for relapsing-remitting multiple sclerosis (MS) target immune cells or other molecules involved in pathogenic pathways with extraordinary specificity. Natalizumab and alemtuzumab are the only two currently approved mAbs for the treatment of MS, having demonstrated significant reduction in clinical and magnetic resonance imaging disease activity and disability in clinical studies. Ocrelizumab and daclizumab are in the late stages of phase III trials, and several other mAbs are in the early stages of clinical evaluation. mAbs have distinct structural characteristics (e.g. chimeric, humanized, fully human) and unique targets (e.g. blocking interactions, induction of signal transduction by receptor binding, complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity) conferring different mechanisms of action in MS. Because of these differences, mAbs for MS do not constitute a single treatment class; each must be considered individually when selecting appropriate therapy. Furthermore, in reviewing the data from clinical studies of mAbs, attention should be drawn to use of different comparators (e.g. placebo or interferon β-1a) and study designs. Each mAb treatment has a unique administration schedule. In the decision to select the appropriate treatment for each individual MS patient, careful review of the benefits relative to risks of mAbs is balanced against the risk of development of MS-associated disability.
Small Signal Stability Assessment of MEPE Test System in Free and Open Source Software

— This paper presents small signal stability study carried over the 140-Bus, 31-Machine, 5-Area MEPE system and validated on free and open source software: PSAT. Well-established linear-algebra analysis, eigenvalue analysis, is employed to determine the small signal dynamic behavior of test system. The aspects of local and interarea oscillations which may affect the operation and behavior of power system are analyzed. Eigenvalue analysis is carried out to investigate the small signal behavior of test system and the participation factors have been determined to identify the participation of the states in the variation of different mode shapes. Also, the variations in oscillatory modes are presented to observe the damping performance of the test system.
eIF4E‐Binding proteins are differentially modified after ammonia versus intracellular calcium activation of sea urchin unfertilized eggs

Fertilization of sea urchin eggs triggers a rise of protein synthesis mainly dependent on the cap‐binding protein eIF4E, which is released from its repressor 4E‐BP and associates with eIF4G. Association of eIF4G with eIF4E is a crucial event for the onset of the first mitotic division following fertilization. Artificial activation of unfertilized eggs with the calcium ionophore A23187 results in the activation of protein synthesis comparable to the one triggered by fertilization, while increasing the intracellular pH by ammonia treatment results in partial activation of protein synthesis. Nevertheless, artificial activation does not induce the mitotic division. Here we investigate the effect of calcium ionophore and ammonia treatment of unfertilized eggs on eIF4E and its two antagonist partners, 4E‐BP and eIF4G. We show that the addition of calcium ionophore to unfertilized eggs induces permanent dissociation between eIF4E and 4E‐BP, whereas a reversible dissociation of the complex occurs after ammonia treatment. The regulation of the complex correlates with permanent or reversible 4E‐BP disappearance depending on the treatment used to trigger artificial activation. Furthermore, while calcium ionophore treatment of unfertilized eggs induces eIF4G modifications comparable to those observed following fertilization, ammonia treatment does not. These results suggest that ionophore and ammonia treatments of unfertilized eggs induce differential protein synthesis activation by targeting eIF4E availability and specific regulation through its two partners 4E‐BP and eIF4G. Mol. Reprod. Dev. 77: 83–91, 2010. © 2009 Wiley‐Liss, Inc.
Magnitude of Antiretroviral Drug Toxicity in Adult HIV Patients in Ethiopia: A cohort study at seven teaching hospitals

Background The introduction of antiretroviral therapy (ART) has resulted in significant mortality reduction and improvement in the quality of life. However, this has come at a cost of increased drug toxicity. The objective of this study was to assess the patterns and predictors of ART toxicity in adult HIV patients in Ethiopia. Methods This is a prospective cohort study conducted at seven teaching hospitals between September 2009 and December 2013 involving 3921 HIV patients on ART. Adverse drug reactions (ADR) due to ART were identified based on clinical assessment and/or laboratory parameters. Multivariable random effects Poisson regression analysis was used to identify factors independently associated with toxicity. Result ADR due to ART drugs was reported in 867 (22.1 %) of the participants; 374 (9.5%) had severe forms. About 87% of reported toxicities were limited to three organ systems — the skin, nervous system and blood. The overall incidence of ADR was 9 per 100 person years. About a third of toxicities occurred during the first six months after ART initiation with the incidence rate of 22.4 per 100 person years. Concomitant anti-tuberculosis treatment was the strongest independent predictor of toxicity. Conclusion ADR was found to be highly prevalent in HIV patients on ART at tertiary hospitals in Ethiopia. Most of these conditions occurred early after ART initiation and in those with concomitant anti-tuberculosis treatment. Thus, routine monitoring of patients on ART should be strengthened with particular emphasis in the first 6 months. Strategies should also be devised to replace older and more toxic agents with newer and safer drugs available.
Alfentanil during rapid sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg: tracheal intubation conditions

Opioids have become an integral part of anaesthesia induction. We aimed to determine the dose of alfentanil needed to obtain perfect tracheal intubation conditions during rapid sequence induction with standard doses of thiopental and rocuronium, where laryngoscopy was initiated 55 s after commencement of drug administration. The influence of covariates (sex, body weight, age, alfentanil plasma concentration at laryngoscopy) was tested.
A Structural Equation Modeling Analysis of the Relationships between Depression, Anxiety, and Sexual Problems over Time

Sexual dysfunctions are related to depressive and anxiety disorders, but the nature of these relationships remains unclear. This study examined the relationship among symptoms of these disorders over time by comparing (a) a model that included causal relationships, (b) a model that accounted for change over time with a shared underlying factor (or latent liability) among all the disorders, and (c) a model that conceptualized sexual dysfunctions as unrelated to depressive and anxiety disorders over time. Participants (n = 1,012) completed online self-report measures of sexual dysfunctions and depressive and anxiety disorders across six time points at either weekly or monthly intervals. Models 1 and 2 provided equal best fit for men and women based on data collected four weeks apart, but there were no evident causal relationships in Model 1. Subsequent analyses using data collected one week and six months apart found Model 2 provided robust fit for women, but these data were not examined for men due to inadequate sample sizes. The results are consistent with a shared latent liability of internalizing psychopathology driving the change in these disorders over time, which provides a clear direction for an empirically driven nosology and for future research into transdiagnostic treatments.
Women's cancers among Alaska Natives 1969-2003.

INTRODUCTION Alaska Native people include multiple, diverse ethnic groups whose ancestors occupied what is now the state of Alaska. Cancer incidence rates among Alaska Native women for breast, cervix, uterus and ovary are presented here. Current rates and trends over time are compared with US White rates. OBJECTIVE To describe cancer incidence patterns for cancer of the breast, cervix, uterus and ovary among Alaska Native women. METHODS Cancer incidence data for Alaska Natives are from the Alaska Native Tumor Registry, in Anchorage, Alaska. Incidence rates for US Whites are from the National Cancer Institute Surveillance, Epidemiology, and End Results Program. RESULTS Breast and cervical cancer incidence rates among Alaska Natives are similar to US White rates, whereas rates for cancer of the uterus and ovary are significantly less than those of US Whites. Thirty-five year trends show increasing rates in breast cancer and decreasing rates of cervical cancer. CONCLUSION The burden of cancer among Alaska Native women for cancers unique to women is significant. Increasing breast cancer rates among Alaska Natives has greatly contributed to this burden.
A flexible array format for large‐scale, rapid blood group DNA typing

BACKGROUND: Typing for blood group antigens is currently performed by hemagglutination. The necessary reagents are becoming costly and limited in availability, and the methods are labor‐intensive. The purpose of this study was to determine the feasibility of the use of large‐scale DNA analysis in a microarray as a substitute for blood group typing.
Peripapillary sparing in RDH12-associated Leber congenital amaurosis

ABSTRACT Background: Peripapillary sparing is a characteristic that is traditionally described as pathognomonic for Stargardt disease. Materials and methods: We present a multimodal assessment of four Leber congenital amaurosis (LCA) cases with congenital macular atrophy and severely attenuated electroretinogram findings caused by bilallelic mutations in RDH12. Results: Fundus autofluorescence imaging revealed a general loss of retinal pigment epithelium across the macula except for the peripapillary region in both eyes of all patients. Spectral domain-optical coherence tomography confirmed relative preservation in this area along with retinal thinning and excavation throughout the rest of the macula. LCA was diagnosed based on clinical exam and retinal imaging, and subsequently confirmed with genetic testing. Conclusions: Peripapillary sparing is a novel phenotypic feature of RDH12-associated LCA.
Homebiased Acquisitions

We show that CEOs exhibit a home bias in acquisitions. Firms are over twice as likely to acquire targets located in their CEOs’ home states than similar targets domiciled elsewhere. The bias is strongest for private targets and when acquirer governance is lax, and these private home deals do not create value, suggesting that CEOs acquire these targets for their own benefits. Unlike typical public deals, however, public home-state acquisitions are value enhancing. CEOs create value in public home-state acquisitions by avoiding extremely poor deals and through synergies driven by efficient integration.
Effects of glucose, growth temperature, and pH on listeriolysin O production in Listeria monocytogenes

Expression of listeriolysin O of Listeria monocytogenes as a function of different growth conditions was studied by performing a direct hemolysin assay, immunoblotting experiments, and an enzyme-linked immunosorbent assay. Expression of listeriolysin O was reduced at a lower growth temperatures (26 degrees C) and at higher glucose concentrations (> or = 0.3%) in the growth media. The effect of glucose appeared to be due to a change in the pH of the growth media.
A Framework for Assessing Enterprise-Wide SOA Implementation Readiness

Many vendors have acclaimed Service Oriented Architecture SOA as a better way to design and build enterprise-wide information systems EWIS. While these claims may be true in the private sector, there is scant evidence in the literature for the same success in the public sector. The adoption of Enterprise-wide SOA ESOA as the dominant development paradigm within an organization often requires significant organizational changes, which are difficult to achieve in the public sector, with its strict hierarchies and departmental independence. Although many government departments are beginning to adopt this new paradigm, the literature does not provide a suitable ESOA implementation readiness framework for use in the public sector. This research proposes a framework based on Critical Success Factors CSFs and a CSF scorecard to evaluate an organisation's ESOA implementation readiness. The framework and scorecard were tested in a test case in the Malaysian government, and the results validate the accuracy and usefulness of both the CSF Framework and the CSF Scorecard.
Oxidative Stress Changes in L‐Arginine‐Induced Pancreatitis in Rats

The important role of oxygen radicals in acute experimental pancreatitis was demonstrated by study of the changes in the antioxidant system in the blood, liver, kidney, and pancreas of rats after the administration of a large quantity of L-arginine (L-Arg). The changes in lipid peroxidation and in reduced and oxidized glutathione were followed, as well as the activities of peroxide-decomposing enzymes (glutathione peroxidase and catalase) and H2O2-producing superoxide dismutases. The results demonstrated that “oxidative stress” develops and acute pancreatitis appears rapidly after L-Arg treatment. Oxidative stress symptoms are expressed 24 h after the final treatment. Slow restitution of the studied antioxidant system can be demonstrated as early as after 48 h.
Unilateral orthostatic headache caused by glaucoma

We read with great interest the paper from Choi et al. (1). The authors reported an angle-closure glaucoma patient whose presenting sign was unilateral orthostatic headache and was successfully treated by glaucoma drainage implant surgery. They presumed that increased intraocular pressure (IOP) was exacerbated by the possible mydriasis resulting from ‘hyperadrenergic’ presentation of the severe orthostatic hypotension due to diabetic autonomic neuropathy. This is a reasonably acceptable explanation for the elevation of IOP in an eye with predisposition to angle closure because such autonomic factors may influence the onset or severity of pupil block. Systemic autonomic dysfunction has been reported in patients with primary angle-closure glaucoma (PACG) (2,3), although Yong and co-workers failed to identify systemic autonomic dysfunction in 16 patients with PACG (4). However, there are some issues that need to be clarified. First, it is well-known that the IOP increases in healthy eyes on assumption of the supine position from the seated upright position (5). Increased episcleral venous pressure and increased ophthalmic artery pressure with the posture change have been suggested as contributory mechanisms for this phenomenon. Such IOP increases with postural alteration were reported to be greater in eyes with glaucoma or diabetes (5,6). In addition, some studies investigated the effect of posture on IOP in patients with systemic autonomic dysfunction and demonstrated larger IOP decreases than normal on upright position in such patients (7,8). Interestingly, the presumed changes of the IOP in this case contrast with the findings of the previous studies. Second, the authors provided only the precipitating factor for the IOP rise and did not explain the mechanism by which the headache and ocular pain were relieved by the postural change. Common clinical scenarios of intermittent (or subacute) angle closure are as follows: angle closure attacks often occur at night or in dim light and disappear later during sleep or after exposure to bright light, both of which are thought to induce miosis. However, this case showed relatively quick relief of the symptoms within 10–15 s upon assumption of the supine position. Mere postural shift to the supine position does not lead to immediate miosis. It seems that other factors such as the gravity and/or the crystalline lens may (if the patient had not undergone cataract surgery) have played a role in relieving the spike of IOP. Gravity may have pulled the peripheral iris and/or the crystalline lens posteriorly, thereby alleviating the appositional closure between the peripheral iris and the trabecular meshwork.
Evaluation of the Dogs, Physical Activity, and Walking (Dogs PAW) Intervention: A Randomized Controlled Trial

BackgroundTo facilitate physical activity (PA) adoption and maintenance, promotion of innovative population-level strategies that focus on incorporating moderate-intensity lifestyle PAs are needed. ObjectiveThe purpose of this randomized controlled trial was to evaluate the Dogs, Physical Activity, and Walking intervention, a 3-month, social cognitive theory (SCT), e-mail-based PA intervention. MethodsIn a longitudinal, repeated-measures design, 49 dog owners were randomly assigned to a control (n = 25) or intervention group (n = 24). The intervention group received e-mail messages (twice weekly for 4 weeks and weekly for 8 weeks) designed to influence SCT constructs of self-efficacy, self-regulation, outcome expectations and expectancies, and social support. At baseline and every 3 months through 1 year, participants completed self-reported questionnaires of individual, interpersonal, and PA variables. Linear mixed models were used to assess for significant differences in weekly minutes of dog walking and theoretical constructs between groups (intervention and control) across time. To test self-efficacy as a mediator of social support for dog walking, tests for mediation were conducted using the bootstrapping technique. ResultsWith the exception of Month 9, participants in the intervention group accumulated significantly more weekly minutes of dog walking than the control group. On average, the intervention group accumulated 58.4 more minutes (SD = 18.1) of weekly dog walking than the control group (p < .05). Self-efficacy partially mediated the effect of social support variables on dog walking. DiscussionResults indicate that a simple SCT-based e-mail intervention is effective in increasing and maintaining an increase in dog walking among dog owners at 12-month follow-up. In light of these findings, it may be advantageous to design dog walking interventions that focus on increasing self-efficacy for dog walking by fostering social support.
Loss of heterozygosity and genomic instability in synchronous endometrioid tumors of the ovary and endometrium

Background. The unknown etiology of endometrioid carcinomas of the ovary and the relatively high frequency of a concomitant carcinoma of the endometrium in these patients warrants study of such tumors. The aim of this study was to identify the genetic alterations involved in endometrioid ovarian cancer development, and to determine whether primary tumors of the endometrium and synchronous primary endometrioid tumors of the ovary could be distinguished based on differing patterns of genetic alterations. The distinction of metastatic carcinoma of the ovary from other synchronous primary tumors is often difficult but has important therapeutic and prognostic implications.
Applied multivariate forecasting model to tourism industry.

Introduction The tourism industry, which comprises 11.7% of total global economic output and supplies 8% of the total number of jobs worldwide, is one of the largest-scale service industries compared with other competitive industries. Thus, the development of the tourism industry not only supplies numerous job opportunities to local residents but also generates considerable foreign exchange earnings for the economy. The globally accepted definition of the "tourism industry" is of a business with multiple aspects, including hotels, restaurants, transportation, entertainment, craft products, and so on. Various forecast models can be adopted for predicting what types of tourism demand are vulnerable to wide fluctuations. This study employs the fuzzy grey model FGM(1,N) and back-propagation neural networks (BPNN) as the multivariate forecasting models. Various benchmark univariate forecasting models are also employed in this study including the naive method, exponential smoothing model, Holt's method, and linear regression. We find that the multivariate forecasting models generates more accurate forecasts than univariate models in the tourism service industry. More specifically, the GM(1,N) model was applied to choose the critical influences on tourism demand. Then, FGM(1,N) model was applied to forecast tourism demand using officially published annual data which show tourists traveling from Taiwan to the United States and to Japan during the period 1990-2003. The results showed that the FGM (1,N) outperformed the benchmark statistical methods during the out-of-sample period. Moreover, when important determinants including service price, foreign exchange rate, population, and per capita income are ranked and selected, the GM(1,N) model was improved and achieved viable performance. Finally, in terms of deciding which model to use, the general finding that can be drawn from this study appears to be that in situations involving little sampling data the grey model is superior to other traditional forecasting models. Further discussion and managerial implication can be drawn from these findings.