Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Nutrition Education and Regular Exercise on Nutritional Status, Quality of Life and Fatigue in Hemodialysis Patients

ABSTRACT The purpose of this study was to investigate the effects of a nutrition education and exercise on nutritional status in hemodialysis patients, with regard to quality of life (QoL), and fatigue. The subjects were divided into two groups : an educated (E) group (11 men and 9 women) and a non-educated (NE) group (7 men and 22 women). The educated group received a nutrition education and a regular exercise program for 3 months. Data on anthropometric indices and biochemical parameters were obtained from medical records. Dietary hab-its and nutrient intake were assessed through questionnaires and three-day food records. QoL (through the SF-36 questionnaire) and fatigue (measured by a visual analogue scale questionnaire) were assessed before and after the interventions. Dietary habit scores regarding food variety and fluid intake control significantly in-creased (P＜0.05) after the nutrition education. Furthermore, the intake of total energy, carbohydrates, Fe, and vitamin A significantly increased (P＜0.05). Vitamin C intake also significantly increased (P＜0.01). Hb levels decreased whereas TG levels increased in the NE group. BUN levels decreased in the E group. After the nu-trition education, QoL aspects, such as feelings of pain and general health, and the total score significantly increased (P＜0.05) and the level of fatigue score decreased (P＜0.01). The results of this study indicate that nutrition education and exercise for hemodialysis patients provides changes in dietary habit, daily nutrient in-take, biochemical parameters, QoL, and the level of fatigue. Therefore, nutrition education and exercise help improve nutritional status and QoL.
The effect of calcium supplementation during pregnancy on fetal and infant growth: a nested randomized controlled trial within WHO calcium supplementation trial

Objective. To evaluate whether prenatal calcium supplementation affects fetal and infant growth during the first year of life. Methods. Ninety-one pregnant women and 159 mothers and their infants enrolled beginning before 20 weeks gestation, and women received daily supplements containing either 1.5 g calcium or placebo. Women were examined by ultrasound at 20, 24, 28, 32 and 36 weeks to evaluate fetal biometry. During the first year after delivery, sub-groups of infants born from mothers participating in the trial were examined to assess infant growth. Anthropometric measurements of the infants were assessed. Mothers were enquired about lactation patterns, morbidities of the infants, separation from the mother, and admission to hospital. Results. Ultrasound measurements of fetal biometry did not show any differences between fetuses whose mothers received calcium supplementation during pregnancy and those who received placebo. Concerning infant growth, the mean weight and head circumference of infants born to calcium-supplemented mothers were similar to those born to placebo-supplemented mothers during the first year of life. The mean mid-arm circumference and mean length were significantly higher in the infants of the calcium group at sixth and ninth month, respectively. But, at 12 months, there were no significant differences in any of the anthropometric measurements. Conclusion. Calcium supplementation during pregnancy of women with low calcium intake does not have a noticeable impact on fetal and infant growth during the first year of life.
Antibiotic resistance and penicillin tolerance in ano-vaginal group B streptococci

Objectives. We sought to determine the prevalence of group B streptococcus (GBS) colonisation and to characterise antibiotic resistance patterns. Methods. Vaginal and ano-rectal cultures were evaluated for GBS colonisation, and antibiotic susceptibility profiles were determined to 15 antibiotics according to the guidelines of the National Committee for Clinical Laboratory Standards. Results. Our GBS prevalence was 30%. All isolates were sensitive to amoxicillin/clavulanic acid, ampicillin, ampicillin/sulbactam, cefotaxime, ceftriaxone, cefuroxime-sodium, imipenem, linezolid, penicillin G and vancomycin. Thirty-two percent of the isolates were resistant to azithromycin, 21% to clindamycin, 25% to erythromycin and 23% to tetracycline. Conclusions. The relatively high rates of resistance to four of the 15 antibiotics tested confirm that for women allergic to penicillin and colonised with GBS, antibiotic sensitivities should be determined. We noticed increasing resistance to clindamycin over a 7-year period. Ongoing surveillance of local antibiotic resistance patterns at the institutional level is important in determining optimal prophylaxis as resistance patterns differ between institutions and are increasing.
Effect of different degrees of glucose intolerance on maternal and perinatal outcomes

Objective. To evaluate the effect of markedly elevated 50-g glucose loading test (GLT) (≥200 mg/dL) and equivocal 100-g GLT (one abnormal value) results on maternal and perinatal outcomes. Methods. Retrospective analysis of 2029 singleton pregnancies screened for gestational diabetes mellitus (GDM). Maternal and perinatal outcomes in five different groups with different degrees of glucose intolerance were compared. First group consisted of patients with normal 50-g test, second group was formed by patients with abnormal 50-g glucose test but a normal 100-g test. Third group included patients with one abnormal value after 100-g test. Patients in the fourth group were diagnosed to have GDM after an abnormal 100-g test. Patients in the fifth group had a value ≥200 mg/dL after 50-g test and were diagnosed to have GDM. Results. Macrosomia and large for gestational age incidence were highest in the group with one elevated glucose tolerance test (GTT) value. Hospitalisation rates, hypoglycemia, hyperbilirubinemia and polycythemia were more common in neonates born to mothers with one elevated GTT value and to mothers with a GLT > 200 mg/dL. Conclusion. Adverse maternal and perinatal outcomes in patients with one elevated GTT value and in patients with a GLT value > 200 mg/dL warrant close glucose monitoring and treatment in these groups even in the absence of a diagnostic abnormal GTT.
Evaluation of Mesenchymal Tumors of Gastrointestinal Tract with Special Reference to Gastrointestinal Stromal Tumors – A Tertiary Care Center Experience

Background: Gastrointestinal tumors (GISTs) have attained significance in recent years because of their dramatic response to imatinib. Imatinib acts by inhibiting the proliferation and inducing apoptosis of GIST cells which express by activating c-kit mutation. GISTs with activating c-kit mutation show positivity for CD117 marker immunohistochemically. In this study, we analyzed the mesenchymal tumors of gastrointestinal tract morphologically and immunohistochemically. Materials And Methods: In this single-institutional retrospective study from January 1995 to April 2010, 52 mesenchymal tumors of gastrointestinal tract were included. Initially they were grouped under smooth muscle and stromal tumors based on their morphology and immunoreactivity for smooth muscle markers. Later on, they were subjected to additional immunostaining by CD117. Based on this, the mesenchymal tumors were reclassified. Results: In our study, the median age was 50 years (range 20-86 years). Stomach was the most common site ( n = 13). After CD117 immunostaining, 16 cases which were originally grouped under smooth muscle tumors were reclassified as GISTs. Conclusion: GISTs showing CD117 positivity are the largest group of mesenchymal tumors of gastrointestinal tract. Categorization of tumors as GIST helps to consider the patients for potential imatinib therapy.
Antifungal azoles for skin disorders

The output from the pharmaceutical industry of new antifungals to treat superficial infections over the last decade has been limited. Notwithstanding the fact that the need to combat life-threatening deep fungal infections is of great importance, there remains an unmet need for compounds to treat superficial infections, especially chronic ones such as onychomycosis and tinea capitis. Azoles still have a pivotal role to fulfill. Both new azole derivatives, with a favourable risk–benefit ratio, and new formulations of older azoles are currently under development in various companies. In the search for novel properties to make azoles attractive, special attention has been paid to mechanisms of action ancillary to the well known ergosterol biosynthesis inhibition and broadened the activity spectrum, including other microorganisms, more favourable pharmacokinetics, fewer drug–drug interactions and more acceptable irritation profiles for drugs intended for topical application. The most recent list of new azoles in early and late clinical development is given in this review, preceded by an overview of presently used medications to treat fungal infections of the skin.
Increased fibroblast density in actinic cheilitis: association with tryptase-positive mast cells, actinic elastosis and epithelial p53 and COX-2 expression.

BACKGROUND Actinic cheilitis (AC) is characterized by epithelial and connective tissue alterations caused by ultraviolet sunlight overexposure known as photodamage. Fibroblasts have been linked to photodamage and tumor progression during skin carcinogenesis; however, their role in early lip carcinogenesis remains unknown. The aim of this study was to assess the density of fibroblasts in AC and normal lip (NL) samples and determine their association with markers of lip photodamage. METHODS Fibroblasts, mast cells, p53, COX-2, and elastin were detected in NL (n = 20) and AC (n = 28) biopsies using immunohistochemistry/histochemistry. Mast cell and fibroblast density and epithelial p53 and COX-2 expression scores were then obtained. Elastosis was scored 1-4 according to elastin fiber density and tortuosity. RESULTS Fibroblasts, mast cells, p53, COX-2, and elastosis were increased in AC as compared to NL (P < 0.001). Multivariate analysis showed an association between fibroblast and mast cell density at the papillary and reticular areas of AC and NL (P < 0.05). Papillary fibroblast density was also associated with epithelial p53 and COX-2 expression (P < 0.05). Increased fibroblast density, both papillary and reticular, was found in the high elastosis group (scores 3-4) as compared to the low elastosis group (scores 1-2) (P < 0.01). Increased reticular mast cell density was detected only in the high elastosis group (P < 0.01). CONCLUSIONS Fibroblasts are increased in AC, and they are associated with mast cell density, epithelial p53 and COX-2 expression, and actinic elastosis. Therefore, fibroblasts may contribute to lip photodamage and could be considered useful markers of early lip carcinogenesis.
Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies

The recurrent 9p24.1 aberrations in lymphoid malignancies potentially involving four cancer‐related and druggable genes (JAK2, CD274/PDL1, PDCD1LG2/PDL2, and KDM4C/JMJD2Cl) are incompletely characterized. To gain more insight into the anatomy of these abnormalities, at first we studied 9p24.1 alterations in 18 leukemia/lymphoma cases using cytogenetic and molecular techniques. The aberrations comprised structural (nine cases) and numerical (nine cases) alterations. The former lesions were heterogeneous but shared a common breakpoint region of 200 kb downstream of JAK2. The rearrangements predominantly targeted the PDL locus. We have identified five potential partner genes of PDL1/2: PHACTR4 (1p34), N4BP2 (4p14), EEF1A1 (6q13), JAK2 (9p24.1), and IGL (22q11). Interestingly, the cryptic JAK2‐PDL1 rearrangement was generated by a microdeletion spanning the 3′JAK2−5′PDL1 region. JAK2 was additionally involved in a cytogenetically cryptic IGH‐mediated t(9;14)(p24.1;q32) found in two patients. This rare but likely underestimated rearrangement highlights the essential role of JAK2 in B‐cell neoplasms. Cases with amplification of 9p24.1 were diagnosed as primary mediastinal B‐cell lymphoma (five cases) and T‐cell lymphoma (four cases). The smallest amplified 9p24.1 region was restricted to the JAK2‐PDL1/2‐RANBP6 interval. In the next step, we screened 200 cases of classical Hodgkin lymphoma by interphase FISH and identified PDL1/2 rearrangement (CIITA‐ and IGH‐negative) in four cases (2%), what is a novel finding. Forty (25%) cases revealed high level amplification of 9p24.1, including four cases with a selective amplification of PDL1/2. Altogether, the majority of 9p24.1 rearrangements occurring in lymphoid malignancies seem to target the programmed death‐1 ligands, what potentiates the therapeutic activity of PD‐1 blockade in these tumors. © 2016 Wiley Periodicals, Inc.
Postnatal counseling on exclusive breastfeeding using video – experience from a tertiary care teaching hospital, south India

Abstract Introduction: Adequate antenatal counseling combined with postnatal lactation support is likely to improve exclusive breastfeeding rates. Objective: To assess the impact of a postnatal video based health education program in promoting exclusive breastfeeding among primiparous mothers. Methods: This interventional study was done in a tertiary care teaching hospital, south India. Primiparous mothers in one postnatal ward (group A) received routine lactation counseling. A similar group of primiparous mothers in another postnatal ward (group B) were administered a video based health education program on exclusive breastfeeding in the local language Tamil in addition to the routine lactation counseling. The exclusive breastfeeding rates of these two groups of mothers were compared. Their knowledge and perceptions after intervention were also compared using a pretested questionnaire. Results: Among 878 primiparous mothers, 94% fed colostrum and 43% initiated breastfeeding within one hour of delivery. Correct attachment was noted with 96% and 13% had lactation issues. Group B had marginally better exclusive breastfeeding rate at six months but not statistically significant. Mothers in group B had a statistically significant better knowledge score post-intervention compared to those in Group A. Use of gripe water was more in group A compared to group B. Conclusion: The video based health education program when combined with routine lactation counseling improved the knowledge regarding exclusive breastfeeding among postnatal primiparous mothers better than with routine lactation counseling alone. However, both interventions had similar effect on exclusive breastfeeding rate at six months.
Oral versus vaginal prostaglandin for labor induction

Abstract Objective: To compare the efficacy and safety of oral prostaglandin (PG) in solution versus vaginal PG gel for labor induction. Design: A retrospective study. Methods: Data from original obstetric records at a university hospital in Sweden 2012–2013. Results: In all women, oral PG resulted in vaginal birth (VB) < 24 h in 66% compared to 80% with vaginal PG (p < 0.001), and cesarean section (CS) in 19% versus 32% (p = 0.02). In primiparous women, oral PG was followed by VB <24 h in 54% compared to 71% (p = 0.01), and CS in 25% versus 41% (p = 0.03). In women with an unripe cervix, oral PG lead to VB <24 h in 66% compared to 79% (p = 0.01), and CS in 21% versus 33% (p = 0.04). Despite a longer induction to vaginal delivery interval with oral PG, the rates of obstetric bleeding, chorioamnionitis, and neonatal asphyxia were not increased. Conclusions: Oral PG in solution was less effective than vaginal PG gel in achieving VB <24 h. However, oral PG was safer, since it resulted in fewer CSs without increasing maternal morbidity or neonatal asphyxia.
Copy number gain of 11q13.3 genes associates with pathological stage in hypopharyngeal squamous cell carcinoma

Squamous cell carcinomas of the hypopharynx (HPSCC) and oropharynx (OPSCC) have markedly different patient outcomes. Differences in HPV prevalence between these two patient groups may account for some of this difference, but other molecular markers of prognosis or pathological phenotype have not been established. Copy number gain of oncogenes is a well‐established molecular change contributing to HNSCC development. Quantitative PCR was used to explore copy number gains of specific genes (3q—PIK3CA, TP63; 11q13.3—CCND1, ANO1) in tumor DNA recovered from HPSCC (n = 48) and OPSCC (n = 52) patients. Associations between copy number gain, patient demographics, HPV/p16INK4a status and pathological stage were examined. HPV/p16 prevalence in HPSCC and OPSCC groups was 2.1% and 46.0%, respectively. HPSCCs had frequent gains of CCND1 (56.3%) and ANO1 (56.3%) but few gains of PIK3CA (6.3%). By contrast, OPSCCs had significantly fewer CCND1 (23.1%) and ANO1 (17.3%) gains, and significantly more PIK3CA (26.9%) gains. A mutually exclusive relationship between HPV/p16 and 11q13.3 gains was observed in OPSCCs, while PIK3CA and TP63 gains were similar across HPV‐associated and smoking/alcohol‐associated patients. ANO1 gain was significantly linked to tumor pathology in HPSCC, associating with nodal metastasis and smaller and less invasive tumors at presentation (P = 0.010). Our results provide a convincing link between a specific molecular change and disease phenotype that appears unique to our HPSCC population, supporting a model of 11q13.3 in promoting metastatic disease progression in HNSCC, and suggest a role for ANO1 as a molecular marker of metastatic disease. © 2016 Wiley Periodicals, Inc.
The impact of maternal- and neonatal-associated factors on human milk's macronutrients and energy

Abstract Objectives: To test the impact of specific maternal- and neonatal-associated factors on human milk's macronutrients and energy. Methods: This study was conducted with the use of a human milk analyzer (HMA, MIRIS, Uppsala, Sweden). Six hundred and thirty samples of raw milk and 95 samples of donor pasteurized milk were delivered from a total of 305 mothers. Results: A significant inverse correlation of fat, protein and energy content with gestational age and birth weight was established. Fat and energy were lower in colostrum, increased in transitional milk and decreased on the 30th day's mature milk compared to transitional. The rate of protein decline from colostrum to mature milk was lower in premature deliveries compared to that of full-terms, resulting in greater contents of protein in preterm mature milk. The upmost amounts of carbohydrates were found in mature milk of preterm deliveries. A positive correlation was found between maternal age and fat contents. In women with higher post-pregnancy BMI levels greater analogies of fat and energy were presented. In women suffering diet-controlled gestational diabetes (GD), lower protein and higher fat and energy levels were found. Conclusions: Prematurity, maternal age, diet-controlled GD and high post-pregnancy BMI levels were found to impose statistical significant effect on milk's macronutrients and energy.
Software para análise quantitativa da deglutição

OBJECTIVE: The present paper is aimed at introducing a software to allow a detailed analysis of the swallowing dynamics. MATERIALS AND METHODS: The sample included ten (six male and four female) stroke patients, with mean age of 57.6 years. Swallowing videofluoroscopy was performed and images were digitized for posterior analysis of the pharyngeal transit time with the aid of a chronometer and the software. RESULTS: Differences were observed in the average pharyngeal swallowing transit time as a result of measurements with chronometer and software. CONCLUSION: This software is a useful tool for the analysis of parameters such as swallowing time and speed, allowing a better understanding of the swallowing dynamics, both in the clinical approach of patients with oropharyngeal dysphagia and for scientific research purposes.
Cosmetic bone contouring

Purpose of review In recent years, cosmetic bone contouring surgery has become increasingly popular, especially in East Asian countries. These procedures are also being requested by patients in the United States at an increasing rate. The purpose of this study is to provide an overview of what is involved with these procedures and their potential complications. Recent findings In some cultures, a wide jaw and a square face are aesthetically unpleasing, whereas an ovoid or ‘melon seed face’ is thought to be feminine, delicate and beautiful. Mandibular angloplasty, mandibular lateral cortex excision, reduction malarplasty, as well as genioplasty may be performed to alter the facial contour and bring about dramatic results. Summary Whether a surgeon choses to incorporate these procedures into practice or not, the craniofacial surgeons should be familiar with the procedures as well as the potential complications.
Impact of sheep and goats ectoparasites on the tanning industry in Tigray Region, Ethiopia

A study was carried out to assess the effect of ectoparasites on the quality of processed skin and defects that cause downgrading and rejection of skins in pickled sheep and wet blue goat-skins at Wukro Sheba tannery in Tigray region. A total of 120 sheep and 120 goat pelts with known infestation by ectoparasites and ectoparasite free control pelts were purchased and processed in Sheba tannery and the corresponding skin defects were analyzed. Accordingly, three groups of 40 sheep pelts each (one group infested with M. ovinus , one group infested with Damalina ovis and a control group of ectoparasite free sheep pelts) and three groups of 40 goat pelts each (one group infested with sarcoptic mange, one group infested with Linognathus spp. and a control group of ectoparasite free goat pelts) were used. Defects observed at pickled stage include cockle, scratch, scar, technical defects due to flaying and old age. A strong association (P<0.001) was observed between cockle lesion and infestation of sheep pelts with D. ovis and Mellophagus ovinus and infestation of goat pelts with sarcoptic mange. Further more, the severity of infestation of sheep pelts with M. ovinus and D. ovis and infestation of goat pelts with sarcoptic mange were found to correlate significantly (P<0.001) with severity of cockle defect. Further investigation on 1000 pickled sheep and 1000 wet blue goat skins revealed that scratch defect was the dominant (43.4 % and 53 %), followed by cockle (35 % and 21.5 %), scar (7 % and 6.8 %) and knife cut (3.4 % and 6.2 %) in pickled sheep and wet blue goat skins, respectively. There was a significant difference (P<0.001) in proportion of cockle between pickled sheep and wet blue goat skins. In addition, a strong association (P<0.001) was observed between cockle and scratch, and cockle and scars on both pickled skins. The economic loss due to quality deterioration of exported skin in the study tannery was estimated to be 778,199.41 USD for pickled sheep and 247,677.61 USD for wet blue goat skins per annum. The growing threat of ectoparasites to small ruminant production and to the tanning industry needs well coordinated and urgent control intervention. Keywords : Ectoparasites, Goat, Sheep, Skin defects, Tigray Region, Ethiopia.