Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation and role of interleukin 6 in wounded human epithelial keratinocytes.

Dermal wounding is accompanied by inflammation and the resulting proinflammatory cytokines, including interleukin (IL)-6, are thought to play an important role in the repair process. IL-6 is produced by normal human keratinocytes to various dermatological diseases and we have recently shown it is also required for normal wound repair. However, neither the events responsible for its induction nor its role in repair have been clearly identified. Using a recently developed in vitro wounding model, we demonstrate that IL-6 mRNA is expressed and immunoreactive IL-6 is released from cultures of human epidermal keratinocytes (NHEKs) following wounding. The transcription factors, NF kappa B and NF-IL-6 (C/EBP beta), which coordinately help regulate IL-6 expression, were activated following wounding and preceded the appearance of IL-6. Addition of IL-1 alpha to NHEK cultures increased IL-6 production and activated NF kappa B and C/EBP beta. Addition of the IL-1 alpha receptor antagonist inhibited both IL-6 mRNA expression and the transcription factors following wounding. Immunoreactive IL-1 alpha was detected in the medium following wounding in the absence of new message. Furthermore, addition of IL-6 to NHEK cultures decreased the expression of keratins 1 and 10, differentiation markers of keratinocytes, while proliferation was not affected. Taken together, these data indicate that constitutive keratinocyte-derived IL-1 alpha is a stimulus for IL-6 production in wounded epidermis, the response involves NF kappa B and C/EBP beta transcription factors, and IL-6 may be associated with modulation of keratinocyte differentiation rather than proliferation.
EDITORIAL COMMITTEE

Note from the Editor . 1 Laurent Thévenot and the French Convention School A Short Introduction by Søren Jagd . 2 The French Convention School and the Coordination of Economic Action. 10 Exchanging Meanings on the Market for Contemporary Art by Olav Velthuis.17 The Modern Gift Institution in Industrial Districts by Glenn Sjöstrand. 28 Book Reviews . 40 Richard Swedberg, Principles of Economic Sociology.40 Olivier Favereau and Emmanuel Lazega (eds), Conventions and Structures in Economic Organization: Markets, Networks and Hierarchies . 45 Reza Azarian, The General Sociology of Harrison White . 48 PhD’s in Progress.50
Etiological Role of Sulfate-Reducing Bacteria in the Development of Inflammatory Bowel Diseases and Ulcerative Colitis

Inflammatory bowel disease and ulcerative colitis are complex multifactorial diseases of unknown etiology. The etiological role of the sulfate-reducing bacteria Desulfovibrio piger Vib-7 and Desulfomicrobium sp. Rod-9 in the development of these inflammatory diseases in rats was studied. Applying sulfate-reducing bacteria, ulcerative colitis in the animals was experimentally induced at the fist time. In total 45 animals in three groups were separated and used in this experiment. Animals in the first group received the standard diet containing a special certified feed for rats and were used as a control. The second group received the standard feed and a dose (1 ml per each day) of modified Kravtsov-Sorokin's liquid medium for the initiation of own potential animal intestinal microflora of sulfate-reducing bacteria. The third group of the animals received the standard feed and dose of a suspension with D. piger Vib-7 and Desulfomicrobium sp. Rod-9 (at a ratio of 1 to 1) in the medium. The changes in the colonic microbiota under these conditions were studied. The bacteria belonging to the normal colonic microbiota were associated with the etiology of inflammatory bowel disease and ulcerative colitis. The concentration of sulfide and acetate in feces from different sections of the large intestine of the rats was determined. The level of ulcerations in the second and third groups of sick animals under the specific conditions was demonstrated. The described experimental results could be particularly useful for the study of inflammatory bowel disease and ulcerative colitis and its therapeutic strategy. These data are also indispensable to apply into mechanistic details that will facilitate better preclinical drug/therapy design to target specific components involved in the disease pathogenesis.
Upper and mid‐mantle anisotropy beneath the Tonga slab

Measurements of source‐side splitting in S waves from events within the Tonga slab reveal anisotropy in the upper and mid‐mantle beneath the slab. We observed splitting for events originating at both upper mantle and transition zone depths. Anisotropic fast directions (ϕ) are trench parallel or sub‐parallel for both upper mantle and transition zone events. Delay times (δt) decrease with depth for upper mantle events. The source of anisotropy for the upper mantle events is likely in the sub‐slab mantle, and is likely indicative of trench parallel flow due to slab rollback. The source of anisotropy for the deeper earthquakes is more difficult to constrain, but the pattern of splitting measurements argues for an uppermost lower mantle anisotropic source, and slab induced deformation may be responsible for this anisotropy as well. Additional constraints from mineral physics studies are necessary to interpret the mid‐mantle anisotropy signal in terms of geodynamical processes.
Moving to Inequality: Neighborhood Effects and Experiments Meet Social Structure1

The Moving to Opportunity (MTO) housing experiment has proven to be an important intervention not just in the lives of the poor, but in social science theories of neighborhood effects. Competing causal claims have been the subject of considerable disagreement, culminating in the debate between Clampet‐Lundquist and Massey and Ludwig et al. in this issue. This article assesses the debate by clarifying analytically distinct questions posed by neighborhood‐level theories, reconceptualizing selection bias as a fundamental social process worthy of study in its own right rather than a statistical nuisance, and reconsidering the scientific method of experimentation, and hence causality, in the social world of the city. The author also analyzes MTO and independent survey data from Chicago to examine trajectories of residential attainment. Although MTO provides crucial leverage for estimating neighborhood effects on individuals, as proponents rightly claim, this study demonstrates the implications imposed by a stratified urban structure and how MTO simultaneously provides a new window on the social reproduction of concentrated inequality.
Impairment of Decision-making Cognition in a Case of Frontotemporal Lobar Degeneration (FTLD) Presenting With Pathologic Gambling and Hoarding as the Initial Symptoms

ObjectiveThe aim of this study was to use the Iowa Gambling Task (IGT) to examine decision-making cognition in a patient with mild frontal variant of frontotemporal dementia (fv-FTD). BackgroundAlthough fv-FTD may present with bizarre and dramatic behavioral changes, traditional executive tasks are sometimes preserved in patients with mild fv-FTD. Some evidence suggests that tasks assessing decision-making cognition, such as the IGT, may be sensitive to detect cognitive dysfunction in patients with mild fv-FTD. Here, we report a patient with fv-FTD who presented with bizarre behavior including hoarding, pathologic gambling, and abnormal sexual behavior. MethodsA 54-year-old man who had been diagnosed as having fv-FTD was examined using a behavioral assessment, a wide range of neuropsychologic tasks, and the IGT. Brain magnetic resonance imaging and brain 99mTc-ethylcysteinate dimer single-photon emission computed tomography examinations were also performed. ResultsAlthough the patient's cognitive abilities were almost fully preserved for a number of traditional neuropsychologic tasks (memory, executive function), the IGT suggested that his decision-making cognition was impaired. The 99mTc-ethylcysteinate dimer single-photon emission computed tomography examination revealed hypometabolism in bilateral medial frontal and orbitofrontal regions of the cerebral cortex, and also in the cingulate gyri. ConclusionsOur findings suggest that the IGT may be a sensitive tool for assessing patients with mild fv-FTD before the development of severe dementia. We speculate that the deficit in decision-making cognition observed in the present case was associated with hypometabolism in the neural networks of the frontal lobe and involving both the bilateral medial frontal and orbitofrontal regions of the cerebral cortex.
The perceptual consequences of interocular suppression in amblyopia.

PURPOSE It is known that information from an amblyopic eye can be strongly suppressed when both eyes are open. The authors investigated the way in which suppression influences the relative perception of suprathreshold contrast and luminance between a person's eyes under dichoptic viewing conditions. METHODS Stimuli consisted of four patches of luminance or four patches containing gratings. Two patches were presented to each eye. Ten amblyopes with mild suppression (six strabismic, three anisometropic and strabismic, and one deprivation; mean age, 34.5 years) and three control observers with normal vision (mean age, 33.0 years) matched the appearance of the stimuli presented to each eye. The match involved manipulation of either luminance or contrast. RESULTS Amblyopes with mild suppression decreased stimulus luminance in the fellow fixing eye or increased luminance in the amblyopic eye to achieve a match (mean matching luminance, 21.1 and 39.6 cd/m(2) for the fellow fixing eye and the amblyopic eye, respectively; standard luminance, 30 cd/m(2)). This interocular mismatch was also observed when luminance was variable and contrast was kept constant (mean matching luminance, 22.8 cd/m(2) for the fellow fixing eye). On the other hand, the amblyopic eye showed no loss of perceived contrast. There was little or no mismatch between the two eyes of control participants with normal binocular vision. CONCLUSIONS Amblyopes have monocular deficits in contrast perception but dichoptic deficits in luminance perception, suggesting that suppression in its mild form involves luminance processing.
Potentiation Effects of Half-Squats Performed in a Ballistic or Nonballistic Manner

Abstract Suchomel, TJ, Sato, K, DeWeese, BH, Ebben, WP, and Stone, MH. Potentiation effects of half-squats performed in a ballistic or nonballistic manner. J Strength Cond Res 30(6): 1652–1660, 2016—This study examined and compared the acute effects of ballistic and nonballistic concentric-only half-squats (COHSs) on squat jump performance. Fifteen resistance-trained men performed a squat jump 2 minutes after a control protocol or 2 COHSs at 90% of their 1 repetition maximum (1RM) COHS performed in a ballistic or nonballistic manner. Jump height (JH), peak power (PP), and allometrically scaled peak power (PPa) were compared using three 3 × 2 repeated-measures analyses of variance. Statistically significant condition × time interaction effects existed for JH (p = 0.037), PP (p = 0.041), and PPa (p = 0.031). Post hoc analysis revealed that the ballistic condition produced statistically greater JH (p = 0.017 and p = 0.036), PP (p = 0.031 and p = 0.026), and PPa (p = 0.024 and p = 0.023) than the control and nonballistic conditions, respectively. Small effect sizes for JH, PP, and PPa existed during the ballistic condition (d = 0.28–0.44), whereas trivial effect sizes existed during the control (d = 0.0–0.18) and nonballistic (d = 0.0–0.17) conditions. Large statistically significant relationships existed between the JH potentiation response and the subject's relative back squat 1RM (r = 0.520; p = 0.047) and relative COHS 1RM (r = 0.569; p = 0.027) during the ballistic condition. In addition, large statistically significant relationship existed between JH potentiation response and the subject's relative back squat strength (r = 0.633; p = 0.011), whereas the moderate relationship with the subject's relative COHS strength trended toward significance (r = 0.483; p = 0.068). Ballistic COHS produced superior potentiation effects compared with COHS performed in a nonballistic manner. Relative strength may contribute to the elicited potentiation response after ballistic and nonballistic COHS.
InAlN‐barrier HFETs with GaN and InGaN channels

Advantages and drawbacks of InN‐containing GaN‐based heterostructure field‐effect transistors (HFETs) are reviewed. The main attention is paid to fundamental processes and experimental observations associated with hot‐electron transport in two‐dimensional electron gas (2DEG) channels subjected to high electric fields. Complementary information is obtained from fluctuations. When interface roughness and alloy scattering are minimized, an important transport limitation originates from additional scattering of hot electrons by non‐equilibrium longitudinal optical (LO) phonons (hot phonons) governed by the hot‐phonon temperature and the hot‐phonon decay into acoustic phonons. The ultrafast decay is observed for high supplied power where the hot‐phonon lifetime of ∼60 fs is found. The optimal 2DEG density for the fastest decay of hot phonons is estimated and associated with LO‐phonon–plasmon resonance. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hypertension prevalence and its associated risk factors in adults: a population-based study in Pelotas.

OBJECTIVE To determine hypertension prevalence and its associated risk factors. METHODS A cross-sectional, population-based study of people ages 20 to 69 living in the urban area of Pelotas, Rio Grande do Sul, Brazil, was conducted. The dependent variable systemic hypertension was defined as blood pressure > or = 160 x 95 mm Hg (average of two readings) or current use of antihypertensive drugs. RESULTS Among the 1,968 subjects enrolled in the study, hypertension prevalence was 23.6% (95% CI 21.6 to 25.3). A Poisson regression model was used to control confounding factors effects. The following variables remained statistically significant in the final model: family income, age, skin color, gender, family history of hypertension, extra salt intake, and body mass index. CONCLUSION Compared with a similar study undertaken in 1992, hypertension prevalence increased, particularly in the younger groups.
Effects of feeding medium-chain triacylglycerols on maternal lipid metabolism and pup growth in lactating rats

To study the effects of medium-chain triacylglycerols (MCT) on maternal lipid metabolism and pup growth, MCT (200 g/kg) were incorporated into a commercial chow diet and fed to lactating rats for 8–10 d. The results were compared with similar diets containing sunflower oil (polyunsaturated fatty acids; PUFA), tristearin (saturated fatty acid) or triolein (monounsaturated fatty acid). There was decreased food and energy intake with the MCT diet and this was accompanied by decreased (35%) pup growth. All the high-fat diets inhibited lipogenesis in vivo in the lactating mammary gland, the order of effectiveness being PUFA > triolein > tristearin > MCT. Only the MCT diet increased the rate of hepatic lipogenesis (180%). Experiments feeding an MCT meal containing [l-14C]octanoate indicated that very little (3–4%) of the C was present in mammary gland lipid, unlike the findings with [l-14C]triolein meal (40%). The major portion (65%) of the absorbed [l-I4C]octanoate was oxidized to 14CO2. There was no evidence for adaptation of the mammary gland to increased dietary lipid uptake on the triolein or MCT diets. It is concluded that the decreased pup growth on the MCT diet is due in part to the decreased energy intake and to the inability of dietary medium-chain fatty acids to provide substrates for milk lipid synthesis.
Wavelet analysis and synthesis of fractional Brownian motion

Fractional Brownian motion (FBM) offers a convenient modeling for nonstationary stochastic processes with long-term dependencies and 1/f-type spectral behavior over wide ranges of frequencies. Statistical self-similarity is an essential feature of FBM and makes natural the use of wavelets for both its analysis and its synthesis. A detailed second-order analysis is carried out for wavelet coefficients of FBM. It reveals a stationary structure at each scale and a power-law behavior of the coefficients' variance from which the fractal dimension of FBM can be estimated. Conditions for using orthonormal wavelet decompositions as approximate whitening filters are discussed, consequences of discretization are considered, and some connections between the wavelet point of view and previous approaches based on length measurements (analysis) or dyadic interpolation (synthesis) are briefly pointed out. >
Improving stroke prognosis

Giving the patient or family a prognosis is essential to sound clinical management, but may be difficult to do accurately and quickly. Most physicians rely on their knowledge of the natural history of the disease, experience, and clinical judgment, although prognostic evaluations can be far from perfect. In the case of stroke, physicians tend to overestimate the likelihood of a good outcome. In one study, only 65% of ischemic and hemorrhagic stroke patients predicted to be alive and independent at 1 year were actually independent; in contrast, predictions of a poor prognosis were 90% accurate. Agreement among physicians was only fair to moderate.1 In another study, the overall accuracy of health care professionals for predicting stroke outcomes was around 65%, with accuracies ranging from 22% to 89%. 2 When formulating prognoses, natural history data are generally available to physicians, although these data are constantly changing. As an example, it is …
Low threshold step well quantum cascade laser emitting at 3 THz

A resonant-phonon THz quantum cascade laser based on Al<inf>0.03</inf>Ga<inf>0.097</inf>As step well is demonstrated. Maximum pulsed operating temperature is 123 K, with threshold current densities as low as 110 A/cm<sup>2</sup> at 10 K and 175 A/cm<sup>2</sup> at 100 K.
An Early T Cell Lineage Commitment Checkpoint Dependent on the Transcription Factor Bcl11b

One Two T T cells develop in the thymus, where they proceed through several developmental stages, losing alternative lineage potential as they progress. The molecular regulation of this developmental process, however, is not fully understood (see the Perspective by Di Santo). P. Li et al. (p. 85, published online 10 June), L. Li et al. (p. 89), and Ikawa et al. (p. 93) now identify expression of the zinc finger transcription factor Bcl11b as the earliest checkpoint in T cell development in mice. Genetic deletion of Bcl11b in developing T cells inhibited commitment to the T cell lineage. Under conditions that should have stimulated T lineage differentiation, Bcl11b-deficient T cell progenitors failed to up-regulate genes associated with lineage-committed T cells and maintained stem cell– and progenitor cell–associated gene expression. In both developing and committed T cells, loss of Bcl11b resulted in the generation of cells that resembled natural killer (NK) cells in both phenotype and function. These NK-like cells could be expanded easily in vitro and possessed antitumor cytotoxicity, but they did not exhibit cytotoxicity against normal cells and were not tumorigenic. Because T cells are much easier to obtain from human patients than NK cells, deletion of Bcl11b in T cells may thus provide a source of easy-to-grow NK cells for cell-based antitumor therapies. A transcription factor is essential for maintenance of T cell identity. The identities of the regulators that mediate commitment of hematopoietic precursors to the T lymphocyte lineage have been unknown. The last stage of T lineage commitment in vivo involves mechanisms to suppress natural killer cell potential, to suppress myeloid and dendritic cell potential, and to silence the stem cell or progenitor cell regulatory functions that initially provide T cell receptor–independent self-renewal capability. The zinc finger transcription factor Bcl11b is T cell–specific in expression among hematopoietic cell types and is first expressed in precursors immediately before T lineage commitment. We found that Bcl11b is necessary for T lineage commitment in mice and is specifically required both to repress natural killer cell–associated genes and to down-regulate a battery of stem cell or progenitor cell genes at the pivotal stage of commitment.
Picaresque Structure and the Angry Young Novel

Although John Wain's Hurry on Down (1953), Kingsley Amis' Lucky Jim (1954), and Iris Murdoch's Under the Net (1954) were all published several years before the cult of the Angry Young Man appeared in Great Britain, the novels were retrospectively-and erroneouslylabeled by some critics as "angry" and their authors grouped with writers of the Angry Movement such as John Osborne and Colin Wilson. Anger did not officially arrive in London until the first production of Look Back in Anger at the Royal Court Theatre on May 8, 1956; Osborne's play, along with the publication of Colin Wilson's The Outsider on May 26, 1956, appeared to herald a new character in English culture, the working-class or lower-middle-class young man who rebels against the bleakness of the Welfare State and retreats into a self-protective shell of angry vituperation at his surroundings. Wain's Charles Lumley, Amis' Jim Dixon, and Murdoch's Jake Donaghue were then seen as prototypes of the Angry Young Man, despite the protestations of Amis and Wain that they were not particularly enraged about anything. And the error of including Iris Murdoch in this group, who at age thirty-five was neither young, angry, nor male, now seems obvious.
Molecular Characterization of Functional and Phylogenetic Genes from Natural Populations of Methanotrophs in Lake Sediments

ABSTRACT The 16S rRNA and pmoA genes from natural populations of methane-oxidizing bacteria (methanotrophs) were PCR amplified from total community DNA extracted from Lake Washington sediments obtained from the area where peak methane oxidation occurred. Clone libraries were constructed for each of the genes, and approximately 200 clones from each library were analyzed by using restriction fragment length polymorphism (RFLP) and the tetrameric restriction enzymesMspI, HaeIII, and HhaI. The PCR products were grouped based on their RFLP patterns, and representatives of each group were sequenced and analyzed. Studies of the 16S rRNA data obtained indicated that the existing primers did not reveal the total methanotrophic diversity present when these data were compared with pure-culture data obtained from the same environment. New primers specific for methanotrophs belonging to the generaMethylomonas, Methylosinus, andMethylocystis were developed and used to construct more complete clone libraries. Furthermore, a new primer was designed for one of the genes of the particulate methane monooxygenase in methanotrophs, pmoA. Phylogenetic analyses of both the 16S rRNA and pmoA gene sequences indicated that the new primers should detect these genes over the known diversity in methanotrophs. In addition to these findings, 16S rRNA data obtained in this study were combined with previously described phylogenetic data in order to identify operational taxonomic units that can be used to identify methanotrophs at the genus level.