Miracle-dz/UniFAR-FTUs huggingface dataset:
Voltage-gated potassium channel antibody-associated encephalitis with claustrum lesions.

A 65-year-old woman presenting with an acute onset ofconsciousness disturbance was referred to our emergencydepartment. During the examination, she was comatose andhad clonic seizures. Her brain MRI showed symmetric ab-normal signal intensities localized in the bilateral medialtemporal lobes and claustrum (Picture). The serum anti-voltage-gated potassium channel (VGKC) antibody was ele-vated (1,207 pM; normal range <100 pM). Her symptomsand MRI abnormalities improved after corticosteroid ther-apy, but memory loss persisted. In most cases of VGKCantibody-associated encephalitis, the MRI shows abnormalsignal intensities in the bilateral/unilateral medial temporallobes or no significant abnormalities. MRI abnormalities inthe bilateral claustrum have rarely been reported in encepha-litis whereas some cases involve the claustrum symmetri-cally (1, 2). Although the functions of the claustrum andsigns of damage to this area remain unclear, symmetricclaustrum lesions (1, 2), in addition to medial temporal lobelesions, are suggestive of immune-mediated encephalitis, asseen in our patient.
Extent of principals’ human resource management practices for teachers’ job involvement in secondary schools in Anambra State

This study was carried out to empirically ascertain the human resource management practices of principals for teachers’ job involvement in public and private Secondary School in Anambra State. The study was guided by two research questions and two hypotheses. The descriptive survey research design was adopted for the study. All the public and private secondary schools in the six education zones in Anambra state were covered. The population of the study comprised 11,925 respondents made up of 608 principals and 11,318 teachers. The sample for this study comprised 3,576 respondents made of 76 principals and 1,733 teachers in public and 105 principals and 1,662 teachers in private secondary schools in Anambra State respectively. The instrument for data collection was researchers-developed questionnaire made up of two versions: one for principals and one for teachers. The face and content validity of the instrument was established by three experts. Cronbach alpha method was used to obtain co-efficients of 0.82, and 0.81 respectively for each of the two versions of the instrument. The researchers collected the data from the respondents. Respectively, mean ratings and t-test were used to answer the research questions and test the hypotheses at 0.5 level of significance. Findings revealed that public secondary school principals and teachers indicated very low extent of the conduct of induction and orientation for teachers’ job involvement while the principals and teachers in private secondary schools indicated great extent of the conduct of induction and orientation for teachers’ job involvement in their schools. It was among others recommended that proprietors of private schools should encourage staff training among their staff for teachers’ job involvement in order to maintain education standard in their schools. Keywords: Principals; Human Resource Management; Practice; Teachers; Job Involvement; and Secondary Education
Muscular adaptations and insulin‐like growth factor‐1 responses to resistance training are stretch‐mediated

Introduction: Modulation of muscle characteristics was attempted through altering muscle stretch during resistance training. We hypothesized that stretch would enhance muscle responses. Methods: Participants trained for 8 weeks, loading the quadriceps in a shortened (SL, 0–50° knee flexion; n = 10) or lengthened (LL, 40–90°; n = 11) position, followed by 4 weeks of detraining. Controls (CON; n = 10) were untrained. Quadriceps strength, vastus lateralis architecture, anatomical cross‐sectional area (aCSA), and serum insulin‐like growth factor‐1 (IGF‐1) were measured at weeks 0, 8, 10, and 12. Results: Increases in fascicle length (29 ± 4% vs. 14 ± 4%), distal aCSA (53 ± 12% vs. 18 ± 8%), strength (26 ± 6% vs. 7 ± 3%), and IGF‐1 (31 ± 6% vs. 7 ± 6%) were greater in LL compared with SL muscles (P < 0.05). No changes occurred in CON. Detraining decrements in strength and aCSA were greater in SL than LL muscles (P < 0.05). Conclusions: Enhanced muscle in vivo (and somewhat IGF‐1) adaptations to resistance training are concurrent with muscle stretch, which warrants its inclusion within training. Muscle Nerve 49: 108–119, 2014
Evidence that the cell wall of Bacillus subtilis is protonated during respiration

Several independent experiments suggest that cell walls of Bacillus subtilis are protonated during growth. When cells were grown in the presence of fluorescein-labeled dextran to saturate the cell walls, centrifuged, and suspended in PBS, fluorescence-activated cell sorter analyses revealed the bacteria were only poorly fluorescent. In contrast, when the bacteria were purged with N2 to dissipate protonmotive force (pmf) fluorescence became intense. Upon reconstitution of the pmf with phenazine methosulfate, glucose, and oxygen, fluorescence declined. Another approach used pH-dependent chemical modification of cell walls. The walls of respiring B. subtilis cells were amenable to carboxylate modification by [14C]ethanolamine and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The carbodiimide activation of carboxylate groups occurs only in acidic conditions. Upon dissipation of pmf the walls were refractory to chemical modification. Ammonium groups can be condensed with FITC in alkaline medium, but the condensation is very slow in acidic buffers. It was found that the derivatization of the walls with FITC could occur in the absence of pmf. The use of pH-dependent fluorophores and pH-dependent chemical modification reactions suggest that cell walls of respiring B. subtilis cells have a relatively low pH environment. This study shows a bacterium has a protonated compartment. Acidification of cell walls during growth may be one means of regulating autolytic enzymes.
A novel task for examining strategic planning: Evidence for impairment in children with ADHD

Children with attention deficit hyperactivity disorder (ADHD) often show poor performance on tasks that require strategic planning. To assess this ability, we developed a paper and pencil task that required consistent use of a simple test-taking strategy to maximize the number of points. The visual discrimination task with minimal cognitive demands required children to maximize their gains by responding only to outlined high-point problems and to skip the low-point problems. The task was administered twice, the second time with explicit instructions on how to implement the strategy. Few of the children in the ADHD or control group, ages 8–13 years, were able to discover the strategy on their own, but after explicit instruction 90% of the children in the control group but only 57.5% of children with ADHD used the strategy to maximize points (p < .005). The ADHD group used the strategy less efficiently, despite the fact that they did not differ on the total number of problems completed. The findings suggest that children with ADHD have impaired ability to implement strategic approaches for tasks similar to school assignments. The task can potentially be developed as a diagnostic aid and as a basis for further research assessing strategic planning in ADHD.
Psychological test profiles of USAF pilots before training vs. type aircraft flown.

BACKGROUND Student pilots in the USAF are selected for fighter, bomber, or airlift/tanker tracks after basic flight training. This selection needs to be accurate in order to save time and training costs. The objective of this study was to determine whether significant psychological differences exist between pilots flying different types of aircraft and whether these differences could predict who will become a fighter pilot (FP) vs. a bomber pilot (BP) or airlift/tanker pilot (AP). METHODS Pilots who took the Multidimensional Aptitude Battery (MAB) and NEO Personality Inventory Revised (NEO-PI-R) were linked to their aircraft type using primary USAF specialty codes. The data for 2105 pilots was analyzed using MANOVA and Bonferroni post hoc analysis to evaluate for relationships between test results and airframe assignment. RESULTS A statistically significant difference was found between FP and AP pilot means on all segments of the MAB and portions of the NEO-PI-R. The mean scores of the FP group were higher on all IQ facets of the MAB. On the NEO-PI-R, the FP group scored lower on agreeableness and higher on conscientiousness. DISCUSSION The homogeneity of the pilot population gives the statistical difference in scores limited practical value for predicting which aircraft a pilot is best suited to fly. However, scores on these tests clearly could be a useful adjunct, along with flight training grades and personal desires, in determining a student pilot's potential for success in the multi-tasking environment of the fighter pilot.
Understanding Inflation in Emerging and Developing Economies

Emerging market and developing economies (EMDEs) have experienced an extraordinary decline in inflation since the early 1970s. After peaking in 1974 at 17.3 percent, inflation in these economies declined to 3.5 percent in 2017. Despite a checkered history of managing inflation among many EMDEs, disinflation occurred across all regions. This paper presents a summary of a recent book,"Inflation in Emerging and Developing Economies: Evolution, Drivers, and Policies,"that analyzes this remarkable achievement. The findings suggest that many EMDEs enjoy the benefits of stability-oriented and resilient monetary policy frameworks, including central bank transparency and independence. Such policy frameworks need to be complemented by strong macroeconomic and institutional arrangements. Inflation expectations are more weakly anchored in EMDEs than in advanced economies. In EMDEs that do not operate inflation targeting frameworks, exchange rate movements tend to have larger and more persistent effects on inflation.
Myocardial remodeling in hypertensive Ren-2 transgenic rats.

Rats harboring the mouse Ren-2 transgene develop hypertension despite low levels of plasma renin. We determined the extent of left ventricular remodeling present in Ren-2 rats at 16 weeks of age by measuring blood pressure, ratio of heart weight to body weight, left ventricular wall thickness, passive (diastolic) left ventricular compliance, and left ventricular collagen content using hydroxyproline and collagen area fraction. Changes in perivascular fibronectin and collagen type I and III were examined with immunohistochemistry. Blood pressure values at time of death were 244 +/- 15 mm Hg for Ren-2 rats (mean +/- SD, n = 5). Ratios of heart weight to body weight (grams per kilogram) for Ren-2 animals were 4.1 +/- 0.2 versus 3.1 +/- 0.1 for controls (n = 6, P < .001). Wall thickness values for control animals were 2.6 +/- 0.1 versus 4.1 +/- 0.4 mm for Ren-2 animals (P < .001). Left ventricular Ren-2 hydroxyproline measurements were significantly decreased (3.4 +/- 0.2 versus 4.7 +/- 0.9 mg/g dry wt for controls). Significant decreases of approximately 30% were also observed in collagen area fraction in Ren-2 rats. Immunohistochemical and picrosirius red staining indicated increased amounts of perivascular fibrosis in all Ren-2 animals (when compared with controls) with enhanced levels of perivascular fibronectin and type I and type III collagen proteins. Left ventricular compliance measurements indicated a decrease in left ventricular volume for all left ventricular pressures (P = .07). (ABSTRACT TRUNCATED AT 250 WORDS)
Entrepreneurial Risk-Taking, Young Firm Dynamics, and Aggregate Implications

Despite the importance of high-growth young firms for economic growth, determinants of their growth and survival dynamics are not well understood. In this study, I develop a dynamic occupational choice model that identifies a key predictor of the early growth trajectory of young firms: the outside options of the business founders. I show that entrepreneurs with higher outside options as paid workers tend to take larger business risks, and thus exhibit a more up-or-out type of firm dynamics. I find empirical support for the model's predictions using a large founder-firm matched data set built from administrative databases of the U.S. Census Bureau. I find that controlling for past business performance, young firms operated by entrepreneurs with higher outside options exhibit (i) higher firm exit rates, (ii) more growth dispersion, and (iii) faster growth conditioning on survival. With the calibrated model, I find that deterioration in the outside options of entrepreneurs can have a sizable negative impact on aggregate output and productivity via lower risk-taking by young firms and slower growth in their life cycle. These findings indicate that the expected post-failure outcomes of entrepreneurs are an important factor that governs young firm growth as well as aggregate output and productivity.
Response to initial treatment of low and intermediate risk gestational trophoblastic disease with methotrexate and folinic acid.

OBJECTIVES To evaluate the response and toxicity of methotrexate and folinic acid given as primary treatment of low and intermediate risk gestational trophoblastic disease (GTD). MATERIAL AND METHOD Medical records review was performed in patients who received methotrexate and folinic acid as a primary treatment of low and intermediate risk persistent GTD between January 1992 and December 2001. Response was defined as decline of beta human chorionic gonadotropin (hCG) to < or = 5 mlU/ml (remission) after methotrexate and folinic acid treatment. Response rate was estimated and factors associated with response were evaluated. RESULTS Ninety four eligible patients were treated with intramuscular methotrexate and folinic acid. Complete remission was achieved in 64 cases (68%, 95% CI 58-78%). Mucositis (6.4%) and hepatotoxicity (6.4%) were the most common toxicity of methotrexate in the present study and none of these toxic effects was life threatening. Factors associated with response were initial serum hCG < or = 10,000 mlU/ml and stage I disease. CONCLUSION Methotrexate with folinic acid is effective treatment for low and intermediate risk GTD with minimal severe toxicity.
In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings

The mRNA-interactome capture method, which utilizes UV light to cross-link proteins and mRNA in planta, was used to identify the portion of the proteome that binds RNA in etiolated Arabidopsis seedlings. RNA binding proteins (RBPs) control the fate and expression of a transcriptome. Despite this fundamental importance, our understanding of plant RBPs is rudimentary, being mainly derived via bioinformatic extrapolation from other kingdoms. Here, we adapted the mRNA-protein interactome capture method to investigate the RNA binding proteome in planta. From Arabidopsis thaliana etiolated seedlings, we captured more than 700 proteins, including 300 with high confidence that we have defined as the At-RBP set. Approximately 75% of these At-RBPs are bioinformatically linked with RNA biology, containing a diversity of canonical RNA binding domains (RBDs). As no prior experimental RNA binding evidence exists for the majority of these proteins, their capture now authenticates them as RBPs. Moreover, we identified protein families harboring emerging and potentially novel RBDs, including WHIRLY, LIM, ALBA, DUF1296, and YTH domain-containing proteins, the latter being homologous to animal RNA methylation readers. Other At-RBP set proteins include major signaling proteins, cytoskeleton-associated proteins, membrane transporters, and enzymes, suggesting the scope and function of RNA-protein interactions within a plant cell is much broader than previously appreciated. Therefore, our foundation data set has provided an unbiased insight into the RNA binding proteome of plants, on which future investigations into plant RBPs can be based.
Identification and characterization of lymphoid precursors in the murine intestinal epithelium

Although in vivo evidence supports a role for the murine intestinal epithelium in the extrathymic generation of certain intraepithelial T lymphocytes (IEL), no intraepithelial cells with in vitro lymphoid progenitor potential have yet been demonstrated. Using reaggregate fetal thymic organ culture techniques, we show that a subset of CD3– cells isolated from the intestinal epithelium of young mice is capable of generating T cells (α β and γ δ) and NK1.1+ cells in vitro. A novel IEL subset bearing a low level of CD45 was identified and found to comprise cells expressing highly immature lymphoid markers including CD34, c‐kit, CD122, CD127 and high levels of CD16 and CD44. This subset represents 20–30% of intraepithelial CD45+ cells from 4‐week‐old wild‐type and nude mouse strains and contains cells with in vitro T cell differentiation capacity. The identification of such an early pluripotent precursor phenotype within the intestinal epithelium implies that the potential for T cell generation exists at this site, and suggests that extrathymic T cell generation may occur within the epithelium itself.
Elderly Consumers’ Receptiveness to Telemarketing Fraud

The authors use data from the 1996 and 1997 EXCEL Omnibus Survey commissioned by the American Association of Retired Persons to investigate the receptiveness of consumers 50 years of age or older to telemarketing fraud. The authors investigate elderly consumers’ receptiveness to telemarketing fraud, as reflected by a consumer's psychological orientation (willingness to listen to sales pitch and attitude toward callers) and actual engagement in risky behavior (responding to unknown callers) using setwise regression. They conclude with policy implications.
18F-FDG PET for detecting myocardial viability: validation of 3D data acquisition.

UNLABELLED (18)F-FDG PET is an important diagnostic tool for detecting myocardial viability in patients with coronary artery disease. In combination with perfusion scanning, (18)F-FDG PET allows differentiation between reversibly and irreversibly damaged myocardium and selection of patients likely to benefit from revascularization. Viability PET is usually performed in two-dimensional (2D) mode. Taking into account the rising number of three-dimensional (3D)-only scanners, a validation of 3D acquisition is required. METHODS Twenty-one patients with coronary artery disease referred for (18)F-FDG PET underwent an imaging protocol of nongated 2D (2D-NG) and gated 2D (2D-G) acquisitions for 15 min each, followed by 3D gated acquisitions for 10 min (3D-10) and 5 min (3D-5), using an ECAT Exact HR+ scanner. Results were analyzed using a 20-segment polar map in terms of activity concentration (Bq/mL), viability (50% uptake threshold), regional activity distribution, visual assessment of viability based on a 3-point rating scale, and left ventricular ejection fraction. RESULTS Activity concentration measured in each segment with 2D-G, 3D-10, and 3D-5 showed a good linear correlation with 2D-NG. Quantitative viability assessment with 3D-5 gave a sensitivity of 84% and a specificity of 98%, compared with 2D-NG. No differences in regional activity distribution and visual viability assessment were found between the various protocols. Left ventricular ejection fractions obtained with 3D-10 and 3D-5 showed a good linear correlation with those measured with 2D-G. CONCLUSION An ECG-gated 3D imaging protocol gave results comparable to those of 2D acquisition with regard to absolute and regional myocardial activity distribution, left ventricular function, and visual viability assessment. Sensitivity for viability assessment with a 50% uptake threshold was significantly less with 3D, but specificity was maintained. This protocol delivers a clinical performance nearly equivalent to that of 2D acquisition.
Basiliximab (Simulect) for the treatment of steroid-resistant rejection in pediatric liver transpland recipients: a preliminary experience1

Background. The role of interleukin-2 receptor antibodies as rescue therapy in steroid-resistant rejection (SRR) has not been studied. We evaluated the safety and efficacy of an interleukin-2 receptor antibody, basiliximab (Simulect, Novartis, East Hanover, NJ), in treating SRR in pediatric liver transplant recipients. Methods. This was a prospective study of seven pediatric liver transplant recipients with biopsy-proven SRR who would have otherwise received OKT3 or antithymocyte globulin. The primary immunosuppression consisted of cyclosporine (Neoral, Novartis), azathioprine, and prednisolone in four patients and tacrolimus and prednisolone in three patients who had undergone retransplantation for chronic rejection (n=2) and hyperacute rejection (n=1). Four patients had received two cycles of high-dose steroids, and three patients had received a single cycle; all had been converted to tacrolimus, followed by the addition of mycophenolate mofetil. Results. The median time from transplant to SRR was 30 days (range, 8 days–23 months). Five children received two doses of basiliximab (10 mg, 3–7 days apart), and two children received a single dose. Aspartate aminotransferase levels normalized in three children 12, 21, and 30 days after basiliximab treatment. Aspartate aminotransferase levels decreased without normalizing in two children, but there was no further evidence of cellular rejection on repeat biopsies. All five children are rejection-free with a median follow-up of 22 months (range, 5–32 months). Biochemical abnormalities persisted in the remaining two children, and both developed chronic rejection. There were no immediate side effects associated with basiliximab. Two patients were treated empirically for possible cytomegalovirus infection 21 and 57 days after basiliximab treatment, with no evidence of cytomegalovirus disease. Conclusion. Five of seven pediatric liver transplant recipients with SRR experienced successful outcomes with basiliximab treatment without major side effects, indicating that it is a safe alternative to OKT3 and other antilymphocyte antibodies.
Serum insulin‐like growth factor binding protein‐3/prostate‐specific antigen ratio is a useful predictive marker in patients with advanced prostate cancer

Insulin‐like growth factor‐1 (IGF‐1) and insulin‐like growth factor binding protein‐3 (IGFBP‐3) play an important role in regulation of prostate cancer cell growth. We studied the prognostic significance of serum IGF‐1 and IGFBP‐3 levels, and IGF‐1/prostate‐specific antigen (PSA) and IGFBP‐3/PSA ratios in patients with prostate cancer.