Miracle-dz/UniFAR-FTUs huggingface dataset:
Vortices Instead of Equilibria in MinMax Optimization: Chaos and Butterfly Effects of Online Learning in Zero-Sum Games

We establish that algorithmic experiments in zero-sum games "fail miserably" to confirm the unique, sharp prediction of maxmin equilibration. Contradicting nearly a century of economic thought that treats zero-sum games nearly axiomatically as the exemplar symbol of economic stability, we prove that no meaningful prediction can be made about the day-to-day behavior of online learning dynamics in zero-sum games. Concretely, Multiplicative Weights Updates (MWU) with constant step-size is Lyapunov chaotic in the dual (payoff) space. Simply put, let's assume that an observer asks the agents playing Matching-Pennies whether they prefer Heads or Tails (and by how much in terms of aggregate payoff so far). The range of possible answers consistent with any arbitrary small set of initial conditions blows up exponentially with time everywhere in the payoff space. This result is robust both algorithmically as well as game theoretically: 1) Algorithmic robustness: Chaos is robust to agents using any of a general sub-family of Follow-the-Regularized-Leader (FTRL) algorithms, the well known regret-minimizing dynamics, even when agents mix-and-match dynamics, use different or slowly decreasing step-sizes. 2) Game theoretic robustness: Chaos is robust to all affine variants of zero-sum games (strictly competitive games), network variants with arbitrary large number of agents and even to competitive settings beyond these. Our result is in stark contrast with the time-average convergence of online learning to (approximate) Nash equilibrium, a result widely reported as "(weak) convergence to equilibrium".
Large-scale periodic velocity oscillation in the filamentary cloud G350.54+0.69

We use APEX mapping observations of 13CO, and C18O (2-1) to investigate the internal gas kinematics of the filamentary cloud G350.54+0.69, composed of the two distinct filaments G350.5-N and G350.5-S. G350.54+0.69 as a whole is supersonic and gravitationally bound. We find a large-scale periodic velocity oscillation along the entire G350.5-N filament with a wavelength of ~1.3 pc and an amplitude of ~0.12 km/s. Comparing with gravitational-instability induced core formation models, we conjecture that this periodic velocity oscillation could be driven by a combination of longitudinal gravitational instability and a large-scale periodic physical oscillation along the filament. The latter may be an example of an MHD transverse wave. This hypothesis can be tested with Zeeman and dust polarization measurements.
Deuterated forms of H${_3^+}$ and their importance in astrochemistry

At the low temperatures ($\sim$10 K) and high densities ($\sim$100,000 H$_2$ molecules per cc) of molecular cloud cores and protostellar envelopes, a large amount of molecular species (in particular those containing C and O) freeze-out onto dust grain surfaces. It is in these regions that the deuteration of H$_3^+$ becomes very efficient, with a sharp abundance increase of H$_2$D$^+$ and D$_2$H$^+$. The multi-deuterated forms of H$_3^+$ participate in an active chemistry: (i) their collision with neutral species produces deuterated molecules such as the commonly observed N$_2$D$^+$, DCO$^+$ and multi-deuterated NH$_3$; (ii) their dissociative electronic recombination increases the D/H atomic ratio by several orders of magnitude above the D cosmic abundance, thus allowing deuteration of molecules (e.g. CH$_3$OH and H$_2$O) on the surface of dust grains. Deuterated molecules are the main diagnostic tools of dense and cold interstellar clouds, where the first steps toward star and protoplanetary disk formation take place. Recent observations of deuterated molecules are reviewed and discussed in view of astrochemical models inclusive of spin-state chemistry. We present a new comparison between models based on complete scrambling (to calculate branching ratio tables for reactions between chemical species that include protons and/or deuterons) and models based on non-scrambling (proton hop) methods, showing that the latter best agree with observations of NH$_3$ deuterated isotopologues and their different nuclear spin symmetry states.
Observation and study of the decay 
J/ψ→ϕηη′

We report the observation and study of the decay $J/\psi\rightarrow\phi\eta\eta'$ using $1.3\times{10^9}$ $J/\psi$ events collected with the BESIII detector. Its branching fraction, including all possible intermediate states, is measured to be $(2.32\pm0.06\pm0.16)\times{10^{-4}}$. We also report evidence for a structure, denoted as $X$, in the $\phi\eta'$ mass spectrum in the $2.0-2.1$ GeV/$c^2$ region. Using two decay modes of the $\eta'$ meson ($\gamma\pi^+\pi^-$ and $\eta\pi^+\pi^-$), a simultaneous fit to the $\phi\eta'$ mass spectra is performed. Assuming the quantum numbers of the $X$ to be $J^P = 1^-$, its significance is found to be 4.4$\sigma$, with a mass and width of $(2002.1 \pm 27.5 \pm 21.4)$ MeV/$c^2$ and $(129 \pm 17 \pm 9)$ MeV, respectively, and a product branching fraction $\mathcal{B}(J/\psi\rightarrow\eta{}X)\times{}\mathcal{B}(X\rightarrow\phi\eta')=(9.8 \pm 1.2 \pm 1.7)\times10^{-5}$. Alternatively, assuming $J^P = 1^+$, the significance is 3.8$\sigma$, with a mass and width of $(2062.8 \pm 13.1 \pm 7.2)$ MeV/$c^2$ and $(177 \pm 36 \pm 35)$ MeV, respectively, and a product branching fraction $\mathcal{B}(J/\psi\rightarrow\eta{}X)\times{}\mathcal{B}(X\rightarrow\phi\eta')=(9.6 \pm 1.4 \pm 2.0)\times10^{-5}$. The angular distribution of $J/\psi\rightarrow\eta{}X$ is studied and the two $J^P$ assumptions of the $X$ cannot be clearly distinguished due to the limited statistics. In all measurements the first uncertainties are statistical and the second systematic.
A shuffling theorem for lozenge tilings of doubly-dented hexagons

MacMahon's theorem on plane partitions yields a simple product formula for tiling number of a hexagon, and Cohn, Larsen and Propp's theorem provides an explicit enumeration for tilings of a dented semihexagon via semi-strict Gelfand--Tsetlin patterns. In this paper, we prove a natural hybrid of the two theorems for hexagons with an arbitrary set of unit triangles removed along a horizontal axis. In particular, we show that the `shuffling' of removed unit triangles only changes the tiling number of the region by a simple multiplicative factor. Our main result generalizes a number of known enumerations and asymptotic enumerations of tilings. We also reveal connections of the main result to the study of symmetric functions and $q$-series.
Determining the Best Method of Calculating the Large Frequency Separation For Stellar Models

Asteroseismology of solar-like oscillators often relies on the comparisons between stellar models and stellar observations in order to determine the properties of stars. The values of the global seismic parameters, νmax (the frequency where the smoothed amplitude of the oscillations peak) and Δν (the large frequency separation), are frequently used in grid-based modeling searches. However, the methods by which Δν is calculated from observed data and how Δν is calculated from stellar models are not the same. Typically for observed stars, especially for those with low signal-to-noise data, Δν is calculated by taking the power spectrum of a power spectrum, or with autocorrelation techniques. However, for stellar models, the actual individual mode frequencies are calculated and the average spacing between them directly determined. In this work we try to determine the best way to combine model frequencies in order to obtain Δν that can be compared with observations. For this we use stars with high signal-to-noise observations from Kepler as well as simulated Transiting Exoplanet Survey Satellite data of Ball et al. We find that when determining Δν from individual mode frequencies the best method is to use the ℓ = 0 modes with either no weighting or with a Gaussian weighting around νmax.
3D Dense Separated Convolution Module for Volumetric Image Analysis

With the thriving of deep learning, 3D Convolutional Neural Networks have become a popular choice in volumetric image analysis due to their impressive 3D contexts mining ability. However, the 3D convolutional kernels will introduce a significant increase in the amount of trainable parameters. Considering the training data is often limited in biomedical tasks, a tradeoff has to be made between model size and its representational power. To address this concern, in this paper, we propose a novel 3D Dense Separated Convolution (3D-DSC) module to replace the original 3D convolutional kernels. The 3D-DSC module is constructed by a series of densely connected 1D filters. The decomposition of 3D kernel into 1D filters reduces the risk of over-fitting by removing the redundancy of 3D kernels in a topologically constrained manner, while providing the infrastructure for deepening the network. By further introducing nonlinear layers and dense connections between 1D filters, the network's representational power can be significantly improved while maintaining a compact architecture. We demonstrate the superiority of 3D-DSC on volumetric image classification and segmentation, which are two challenging tasks often encountered in biomedical image computing.
Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat's knee.

1. In the spinalized cat, nociceptive spinal neurons with knee input show enhanced responses to mechanical stimulation of that joint once an inflammation has developed in the knee. Enhanced responses may result from increased afferent inflow as well as from modifications of the nociceptive processing within the spinal cord. To examine the significance of these components, we tested in 30 chloralose-anesthetized, spinalized cats whether, during development of arthritis, changes of responsiveness in spinal neurons are restricted to stimulation of the inflamed joint or whether responsiveness in these neurons is altered in general. While continuously recording from a neuron, we injected kaolin and carrageenan into one knee and tested the responses to mechanical stimuli applied to the joint and to regions adjacent to and remote from the knee during the developing arthritis. In addition, in six cats we monitored the neurons' responses to electrical stimulation of the sural nerves and the rostral lumbar spinal cord. 2. Of 32 neurons in laminae VI, VII, and VIII of the lumbar spinal cord, 15 ascending and eight nonascending cells were driven by mechanical stimulation of one or both knee joint(s). Nine of these were nociceptive specific (NS), responding exclusively or predominantly to noxious compression of the knee and other deep tissue, and 12 were wide-dynamic-range (WDR) cells with graded responses to gentle and noxious stimuli applied to the knee joint(s), deep tissue, and skin. Two neurons with high ongoing discharges had some excitatory joint input but showed marked inhibition by most stimuli used (INH neurons). The majority of the neurons had receptive fields on both legs. Nine of the 32 neurons had no input from the knee(s). 3. All 23 neurons with joint input became sensitive or more responsive to movements and gentle compression of the inflamed knee once the inflammation had developed. In general, these neurons also showed enhanced responses to compression of the adjacent muscles in thigh and lower leg. In 20 neurons, response properties were even altered for stimuli applied to regions remote from the inflamed joint, including the contralateral leg in 18 cases. We found expansion of initially restricted receptive fields (mainly in NS cells), enhancement of preexisting responses, and/or lowering of threshold to mechanical stimuli applied to these regions; few neurons developed inhibitory reactions. (ABSTRACT TRUNCATED AT 400 WORDS)
Consistent and Accurate Frequency Oracles under Local Differential Privacy

Local Differential Privacy (LDP) protects user privacy from the data collector. LDP protocols have been increasingly deployed in the industry. A basic building block is frequency oracle (FO) protocols, which estimate frequencies of values. While several FO protocols have been proposed, their resulting estimations, however, do not satisfy the natural consistency requirement that estimations are non-negative and sum up to 1. In this paper, we study how to add post-processing steps to FO protocols to make them consistent while achieving high accuracy for a wide range of tasks, including frequencies of individual values, frequencies of the most frequent values, and frequencies of subsets of values. We consider 10 different methods, some of them explicitly proposed before in the literature, and others introduced in this paper. We establish theoretical relationships between some of them and conducted extensive experimental evaluations. Among them, we propose to use Norm-Hyb, which keeps estimations above a certain threshold unchanged, and then converts negative estimations to 0 while adding a value (typically negative) to all other estimations to ensure a sum of 1.
Effective parameter estimation methods for an ExcitNet model in generative text-to-speech systems

In this paper, we propose a high-quality generative text-to-speech (TTS) system using an effective spectrum and excitation estimation method. Our previous research verified the effectiveness of the ExcitNet-based speech generation model in a parametric TTS framework. However, the challenge remains to build a high-quality speech synthesis system because auxiliary conditional features estimated by a simple deep neural network often contain large prediction errors, and the errors are inevitably propagated throughout the autoregressive generation process of the ExcitNet vocoder. To generate more natural speech signals, we exploited a sequence-to-sequence (seq2seq) acoustic model with an attention-based generative network (e.g., Tacotron 2) to estimate the condition parameters of the ExcitNet vocoder. Because the seq2seq acoustic model accurately estimates spectral parameters, and because the ExcitNet model effectively generates the corresponding time-domain excitation signals, combining these two models can synthesize natural speech signals. Furthermore, we verified the merit of the proposed method in producing expressive speech segments by adopting a global style token-based emotion embedding method. The experimental results confirmed that the proposed system significantly outperforms the systems with a similarly configured conventional WaveNet vocoder and our best prior parametric TTS counterpart.
Social support network typologies and health outcomes of older people in low and middle income countries – A 10/66 Dementia Research Group population-based study

Abstract This study aims to assess the construct validity of the Wenger social support network typology in low and middle income countries. We hypothesize that, in comparison with the integrated network type, the non-integrated network type is associated with loneliness, depression, poor quality of life (less happiness), poor self-reported health, increased disability and higher care needs. Cross-sectional one-phase surveys were conducted of all residents aged 65 and over in catchment areas in eight low and middle income countries (India, China, Cuba, Dominican Republic, Venezuela, Mexico, Peru and Puerto Rico). Wenger's Practitioner Assessment of Network Type (PANT) was used to measure social network type. Family dependent, local self-contained, wider community-focused and private restricted network types were considered non-integrated, in comparison to the locally integrated network type. Overall, 17,031 participants were interviewed. Family dependent and locally integrated network types were the most prevalent. Adjusted pooled estimates across sites showed that loneliness, depression, less happiness, poor health, disability, and need for care were significantly associated with non-integrated network type. The findings of this study support the construct validity of Wenger's network typology in low and middle income countries. However, further research is required to test the criterion validity of Wenger typology using longitudinal data. Identifying older people who are vulnerable could inform the development of social care interventions to support older people and their families in the context of deteriorating health.
The Moderating Effect of Education and Experience on the Use of Learning Management Systems

Based on the technology acceptance model, this research investigated the variables that affect students' use of LMS in Saudi public universities. The study also examined the moderating impact of education and experience on the students' behavior toward LMS. 851 online surveys were submitted by students at three Saudi universities, and 833 responses were used for data analysis. The collected data were analyzed using Partial Least Squares Structural Equation Modelling along with multigroup analysis. Amongst 40 paths, the results revealed that education and experience moderated only four relationships in the proposed model. Discussions, insights and implications for decision makers in Saudi higher education are provided at the end of this paper.
Dendritic Cell Immunogenicity Is Regulated by Peroxisome Proliferator-Activated Receptor γ1

Dendritic cells (DC) are the most potent APCs known that play a key role for the initiation of immune responses. Ag presentation to T lymphocytes is likely a constitutive function of DC that continues during the steady state. This raises the question of which mechanism(s) determines whether the final outcome of Ag presentation will be induction of immunity or of tolerance. In this regard, the mechanisms controlling DC immunogenicity still remain largely uncharacterized. In this paper we report that the nuclear receptor peroxisome proliferator-activated receptor γ (PPAR-γ), which has anti-inflammatory properties, redirects DC toward a less stimulatory mode. We show that activation of PPAR-γ during DC differentiation profoundly affects the expression of costimulatory molecules and of the DC hallmarker CD1a. PPAR-γ activation in DC resulted in a reduced capacity to activate lymphocyte proliferation and to prime Ag-specific CTL responses. This effect might depend on the decreased expression of costimulatory molecules and on the impaired cytokine secretion, but not on increased IL-10 production, because this was reduced by PPAR-γ activators. Moreover, activation of PPAR-γ in DC inhibited the expression of EBI1 ligand chemokine and CCR7, both playing a pivotal role for DC migration to the lymph nodes. These effects were accompanied by down-regulation of LPS-induced nuclear localized RelB protein, which was shown to be important for DC differentiation and function. Our results suggest a novel regulatory pathway for DC function that could contribute to the regulated balance between immunity induction and self-tolerance maintenance.
Purification and Characterization of an X-Prolyl-Dipeptidyl Peptidase from Lactobacillus sakei

ABSTRACT An X-prolyl-dipeptidyl peptidase has been purified fromLactobacillus sakei by ammonium sulfate fractionation and five chromatographic steps, which included hydrophobic interaction, anion-exchange chromatography, and gel filtration chromatography. This procedure resulted in a recovery yield of 7% and an increase in specificity of 737-fold. The enzyme appeared to be a dimer with a subunit molecular mass of approximately 88 kDa. Optimal activity was shown at pH 7.5 and 55°C. The enzyme was inhibited by serine proteinase inhibitors and several divalent cations (Cu2+, Hg2+, and Zn2+). The enzyme almost exclusively hydrolyzed X-Pro from the N terminus of each peptide as well as fluorescent and colorimetric substrates; it also hydrolyzed X-Ala at the N terminus, albeit at lower rates. Km s for Gly-Pro- and Lys-Ala-7-amido-4-methylcoumarin were 29 and 88 μM, respectively; those for Gly-Pro- and Ala-Pro-p-nitroanilide were 192 and 50 μM, respectively. Among peptides, β-casomorphin 1-3 was hydrolyzed at the highest rates, while the relative hydrolysis of the other tested peptides was only 1 to 12%. The potential role of the purified enzyme in the proteolytic pathway by catalyzing the hydrolysis of peptide bonds involving proline is discussed.
Statistical power comparisons among alternative morphometric methods.

This paper compares the statistical power of various tests that have been proposed to test for equality of shape in two populations. Power surfaces are computed with emphasis on the simplest case of three points in the plane (i.e., landmarks at the vertices of a triangle). Goodall's ([1991] J Roy Stat Soc Serb 53:285-339) F-test was found to have the highest power followed by T(2)-tests using Kendall tangent space coordinates. Power for T(2)-tests using Bookstein shape coordinates was good if the baseline was not the shortest side of the triangle. The Rao and Suryawanshi ([1996] Proc Natl Acad Sci 93:12132-12136 and Rao and Suryawanshi [1998] Proc Natl Acad Sci 95:4121-4125) shape variables had much lower power when triangles were not close to being equilateral. Power surfaces for the EDMA-I T statistic revealed very low power for many shape comparisons including those between very different shapes. Power surface for the EDMA-II Z statistic were also complicated and depended strongly on the choice of baseline used for size scaling. The type I error rate was also often not correct for this method. Results for more than three landmarks are also presented. The implications of the results for practical applications of morphometrics are discussed.
Substance loss caused by scaling with different sonic scaler inserts--an in vitro study.

BACKGROUND, AIMS Depending on the phase of periodontal treatment, power-driven inserts with different power levels are necessary: during initial treatment and flap operations, it must be possible to remove calculus which firmly adheres to the root surface with great efficiency; in contrast, gentle root-surface instrumentation has a high priority during maintenance treatment. Recently, modified sonic scaler inserts have been introduced: diamond-coated inserts for open flap operations and slim probe-shaped sonic scaler inserts for deplaqueing during maintenance. METHOD We compared the substance removal by these inserts to that of a conventional insert. In a bench system which allows application force, stroke height, and width and frequency of instrumentation to be monitored and also permits assessment of the topography before and after instrumentation (yielding depth removal and removed volume), we instrumented aluminum rods in triplicate and bovine roots in a 5-fold repetition. RESULTS With high application forces (1.0 N), the diamond-coated inserts removed 30 to 50% more substance than the conventional one. Except for the slim inserts, there was a significant linear relationship between increasing force and removed volume. Probe-shaped inserts do not remove considerable substance even with increasing pressures. CONCLUSIONS Diamond-coated inserts remove tooth substance very effectively and must thus be handled with care: more pressure effects more removal. Probe-shaped inserts can be used without risk during maintenance visits.