Miracle-dz/UniFAR-FTUs huggingface dataset:
Predictive Factors and Risk Model for Positive Circumferential Resection Margin Rate After Transanal Total Mesorectal Excision in ith Rectal Cancer 2653 Patients W

Objective: The aim of this study was to determine the incidence of, and preoperative risk factors for, positive circumferential resection margin (CRM) after transanal total mesorectal excision (TaTME). Background: TaTME has the potential to further reduce the rate of positive CRM for patients with low rectal cancer, thereby improving oncological outcome. Methods: A prospective registry-based study including all cases recorded on the international TaTME registry between July 2014 and January 2018 was performed. Endpoints were the incidence of, and predictive factors for, positive CRM. Univariate and multivariate logistic regressions were performed, and factors for positive CRM were then assessed by formulating a predictive model. Results: In total, 2653 patients undergoing TaTME for rectal cancer were included. The incidence of positive CRM was 107 (4.0%). In multivariate logistic regression analysis, a positive CRM after TaTME was significantly associated with tumors located up to 1 cm from the anorectal junction, anterior tumors, cT4 tumors, extra-mural venous invasion (EMVI), and threatened or involved CRM on baseline MRI (odds ratios 2.09, 1.66, 1.93, 1.94, and 1.72, respectively). The predictive model showed adequate discrimination (area under the receiver-operating characteristic curve>0.70), and predicted a 28% risk of positive CRM if all risk factors were present. Conclusion: Five preoperative tumor-related characteristics had an adverse effect on CRM involvement after TaTME. The predicted risk of positive CRM after TaTME for a specific patient can be calculated preoperatively with the
First Documented Zoonotic Case of Q Fever in Penang, Malaysia

Q fever is a zoonotic disease caused by Coxiella Burnetti. In April 2007, Penang hospital notified a case of brucellosis through the syndromic notification which was later confirmed as Q fever. The patient presented with fever for two weeks and a history of handling the abortus of a goat. An epidemiological investigation was initiated to identify source of infection and prevent transmission. Blood samples from farm worker, contacts and animals from affected and neighboring farms were tested for Q fever. The universal precaution practices of the veterinary and laboratory staff were observed, and their blood specimens were taken for Q fever serology. The patient was tested positive IgM and IgG for Q fever. Out of the 49 blood samples from farm workers, and veterinary and laboratory staff, 12 were positive for IgM, two were positive for IgG, seven were positive for both IgM and IgG, and 67 (27.2%) of the animal farms were positive for Q fever. There were minimal personal protective equipments used by the veterinary staff when handling the animals. There were goats imported from endemic countries. Prior to this outbreak no screening of imported animals for Q fever from endemic countries was instituted. Overall the farms were kept clean and well managed. All the contacts and animals tested positive for Q fever were treated.
Inject Rubrics into Short Answer Grading System

Short Answer Grading (SAG) is a task of scoring students’ answers in examinations. Most existing SAG systems predict scores based only on the answers, including the model used as base line in this paper, which gives the-state-of-the-art performance. But they ignore important evaluation criteria such as rubrics, which play a crucial role for evaluating answers in real-world situations. In this paper, we present a method to inject information from rubrics into SAG systems. We implement our approach on top of word-level attention mechanism to introduce the rubric information, in order to locate information in each answer that are highly related to the score. Our experimental results demonstrate that injecting rubric information effectively contributes to the performance improvement and that our proposed model outperforms the state-of-the-art SAG model on the widely used ASAP-SAS dataset under low-resource settings.
Product Innovation and Discontinuation in Manufacturing and Service Firms in Europe

This study explores product innovation and discontinuation using the firm as a unit of analysis. A key objective of the paper is to compare the results between manufacturing and service firms. The results indicate that the factors affecting product innovation and discontinuation are similar for manufacturing and service firms, where innovation was significant for product/service discontinuation and process innovation was found to be important for innovations. Similarly monopoly power was important for innovation in both industry types. However, there were also some underlying differences, particularly in relation to firm age and economic geography effects. The conclusion of the paper is that it is not appropriate to assume that the process of product innovation and discontinuation will be identical across industry types.
Cross-Class Relevance Learning for Temporal Concept Localization

We present a novel Cross-Class Relevance Learning approach for the task of temporal concept localization. Most localization architectures rely on feature extraction layers followed by a classification layer which outputs class probabilities for each segment. However, in many real-world applications classes can exhibit complex relationships that are difficult to model with this architecture. In contrast, we propose to incorporate target class and class-related features as input, and learn a pairwise binary model to predict general segment to class relevance. This facilitates learning of shared information between classes, and allows for arbitrary class-specific feature engineering. We apply this approach to the 3rd YouTube-8M Video Understanding Challenge together with other leading models, and achieve first place out of over 280 teams. In this paper we describe our approach and show some empirical results.
Inhibition of Human Breast cancer cells proliferation by Graviola crude extract

Rapid increases in cancer and human death cases, as well as the fatal side effects of chemotherapy, have forced the seek new safer anti-cancer drugs. Therefore, the current study was conducted to study the effect of Graviola leaf extract on the proliferation of human breast cancer (MCF-7) cell lines. MCF-7 cells were cultured and a Neutral red uptake assay was done to estimate the effect of Graviola extract on MCF-7 cells'''' proliferation. Treatment with different concentrations of Graviola leaf extract inhibited the proliferation of MCF-7 cells in a concentration-dependent manner. Conclusion: Graviola leaf extract has a promising inhibitory effect against the proliferation of MCF-7 cells.
DDDT_A_203974 2833..2842

Yuanming Ouyang Wei Wang Bing Tu Yi Zhu Cunyi Fan Yanfeng Li 1Department of Orthopedics, Shanghai Sixth People’s Hospital East Campus Shanghai University of Medicine and Health, Shanghai 201306, People’s Republic of China; 2Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China Purpose: Recent findings have identified that SOX9 served as a key role during the pathogenesis of osteoarthritis (OA). This study aimed to investigate the mechanisms by which SOX9 regulated the formation of OA in vitro and in vivo. Materials and methods: The relative expressions of SOX9 in patients with OA and normal fracture of thighbone were analyzed by real-time-PCR. In vitro, IL-1β induced inflammatory response in human chondrocytes was used to evaluate the function of SOX9. The recombinant SOX9 lentivirus vector (Lenti-SOX9) was used to upregulate the expression of SOX9 in cells. ELISAwas used to measure the concentration of tumornecrosis factorα (TNF-α). The protein expressions of SOX9, matrixmetalloproteinase-13 (MMP13), Collagen II, Aggrecan and Smad3 were analyzed by Western blot. Cell proliferation and cell apoptosis were detected by CCK-8 assay and flow cytometry, respectively. In vivo, the effect of SOX9 on surgically induced OA mice was evaluated. Results: The gene level of SOX9 was remarkably downregulated in patients with OA compared with normal people, while the concentration of TNF-α was upregulated. In addition, IL-1β reduced the expressions of SOX9, Collagen II and Aggrecan and increased the level of MMP13 in chondrocytes. Moreover, Lenti-SOX9 notably inhibited IL-1βinduced growth inhibition and apoptosis in chondrocytes via increasing the expression of Smad3. Finally, Lenti-SOX9 markedly alleviated the symptoms of OA mice in vivo. Conclusion: Upregulation of SOX9 inhibited IL-1β-induced inflammatory response via increasing the level Smad3 in human chondrocytes and exhibited therapeutic effect on surgically induced OA mice in vivo. Therefore, SOX9 may serve as a potential target in the treatment of OA in the future.
The EU ETS 3rd Trading Period and Price Formation

Since its introduction, the European Emissions Trading System (EU ETS) has undergone a series of changes in the market design and experienced constant political debates about future adjustments. Particularly, substantially changes have been introduced between the second and the current third trading period. In this paper we analyze whether these changes have effectively fostered market functioning by analyzing the price formation of European Emission Allowances (EUA). We find a strong structural break in price formation around the end of the second trading period. After the break we find a much stronger connection between short term CO2 abatement related variables such as coal and gas prices and EUA prices in the third EU ETS trading period compared to the second trading period. We interpret these findings as evidence for a positive economic effect of the improved market design in the third trading period. Moreover, we find an increasing volatility of EUA returns during the first months of the third trading period. This finding highlights the fact that market reforms did not only improve the functioning of the market, but came at the price of uncertainty among market participants and higher price volatility. Finally, we assess the role of political events for EUA price formation using a GARCH model. Accounting for conditional variance in this way reduces the number of significant policy events considerably compared to other studies on the matter which do not explicitly account for conditional heteroskedasticity. JEL classification:
Modelling and application to emission control and value added product recovery

The development of high efficiency Hurricane r © and ReCyclone r © systems allows their application either to emission control or to value added product recovery. The purpose of this paper is to present not only the performance of these systems, but also a model to predict in a more realistic way the collection efficiency of a gas cyclone with or without partial recirculation. ReCyclone r © systems consist in an optimized reverse-flow cyclone (collector) combined with partial recirculation of un-captured particles via a straight-through cyclone (concentrator). As in improvement of the ReCyclone, it is possible to include a DC electric field in the concentrator to enhance even further particle recirculation to the cyclone collector, leading to higher collection efficiencies. To model the system, a computer program (PACyc Particle Agglomeration in Cyclones) was developed. which starts by estimating the collection efficiency of a system without agglomeration, relying on previously published models to predict collection efficiency either for isolated cyclones or for cyclones with mechanical/electrostatic recirculation. Some experimental results obtained in emission control and value added product recovery are presented, together with the corresponding PACyc predictions on grade and global collection efficiencies.
ANALYSIS OF MULTIDIMENSIONAL POVERTY IN RURAL ADAMAWA STATE, NIGERIA

This study assessed multidimensional poverty in rural parts of Adamawa state, Nigeria. Specifically, the study objectives were to: describe the respondents’ socio-demographic characteristics, determine their multidimensional poverty status, and identify the determinants of multidimensional poverty in the sampled communities. Multi-stage cluster sampling technique was used to collect primary data from 480 household heads selected from 16 villages across the study area. Data collected were analysed using descriptive statistics, Multidimensional Poverty Analytical Tool (MPAT), and Binary Logistic regression model. The respondents’ socio-demographic characteristics described in the study showed that the mean age was 46.3 years, while the average household size was 7 persons. The study indicated that most (86.7%) of the respondents were male, who are mostly married (91.7%), and that majority (74%) are educated. The distribution of the respondents’ multidimensional poverty status revealed that majority (61.7%) of the households were poor. The study revealed that multidimensional poverty in the study area is influenced negatively by age, marital status, and household size. Similarly, gender, educational level, livelihood activities, farm size, livestock ownership, remittance, membership of group, and access to credit positively influence multidimensional poverty. Key among the recommendations of the study is the adequate provision of basic infrastructure in the area.
Multicenter analysis of activity and safety of trastuzumab plus chemotherapy in advanced breast cancer in elderly women (≥ 70 years)

1096 Background: Despite the high prevalence of breast cancer (BC) in elderly pts, no specific trial of activity and safety of trastuzumab (T) has addressed pts older than 70 years, and the only available data are taken from subgroup analyses. Methods: Charts of pts ≥70 with inoperable locally advanced/metastatic BC overexpressing HER2 treated with chemotherapy (CHT) and T in 9 Italian Centers were reviewed. Primary endpoints were response rate (RR), time to progression (TTP), toxicity and cardiac events. Results: Fifty pts were eligible, median age 73.8 years (range 70–92). ECOG PS range was 0–2. Twenty-four pts (48%) were ER negative. 38 pts (76%) had G2-G3 tumors. Cardiovascular risk factors are reported (Table). Taxane-based regimens were used in 28 pts (56%), vinorelbine-based in 18 pts (36%). Basal LVEF was 65% (range 54–78%). A comprehensive geriatric assessment had been done in 10 pts. Partial or complete response was obtained in 29 pts out of 43 evaluable (RR= 67%). Other 12 pts had disease stabi.
Learning by exporting: which channels? An empirical analysis for Turkey

Using a rich longitudinal database at the plant level, this paper tries to shed light on the causal nexus between exports and productivity for Turkey, a middle-income country. We find evidence for both self-selection into exporting and learning-by-exporting. Our main focus is on post-entry effects. To test this hypothesis we follow recent empirical literature and we apply the Propensity score matching approach and a difference-in-difference estimator. We find an higher labour productivity and TFP growth for exporting firms in the entry year and some years following the entry. Exports seem to place firms on a superior productivity path. Empirical evidence shows a strict linkage between export and import activity: export starters often start also importing. Focusing on this firm group, we verify larger productivity gains for firms which start exporting and importing at the same time. Finally, we try to investigate the potential channels of learning-by-exporting. Post-entry effects could be more important in sectors where the productivity gap between domestic market and foreign countries is larger. The finding of heterogeneous effects, according to sectoral comparative advantage, could confirm the theoretical hypothesis that exporting effects are not only scale effects but they works also through competition channel and/or technology transfers.
Chemical Composition of the White Cheese Produced at Household Level in Dueim Area, White Nile State, Sudan

Chemical Composition of the White Cheese Produced at Household Level in Dueim Area, White Nile State, Sudan The present study aimed to determine chemical composition of Jibna-beida produced at small scale-level in Dueim city, the largest market of Jibna-beida in Sudan. The results showed that the protein content of cheese ranged from 14.17 ± 0.058% to 15.73 ± 0.150%, with an average value of 14.57%. Statistically, no significant differences (P ≥ 0.05) in protein of collected cheese samples were found.
Understanding TCP vegas: a duality model

This paper presents a model of the TCP Vegas congestion control mechanism as a distributed optimization algorithm. Doing so has three important benefits. First, it helps us gain a fundamental understanding of why TCP Vegas works, and an appreciation of its limitations. Second, it allows us to prove that Vegas stabilizes at a weighted proportionally fair allocation of network capacity when there is sufficient buffering in the network. Third, it suggests how we might use explicit feedback to allow each Vegas source to determine the optimal sending rate when there is insufficient buffering in the network. We present simulation results that validate our conclusions.
Computer network traffic analysis with the use of statistical self-similarity factor

The optimal computer network performance models require accurate traffic models, which can capture the statistical characteristic of actual traffic. If the traffic models do not represent traffic accurately, one may overestimate or underestimate the network performance. The paper presents confirmation of the self-similar nature of the selected protocols in the computer network communication layer. It shows that the good measure of self-similarity is a Hurst factor.
Impact of note taking during reading and during listening on comprehension

This study aims to determine possible impact of note taking during reading and listening on Turkish Language prospective teachers’ comprehension success. Moreover in the study comprehension scores of the groups were investigated in terms of academic score and gender variables. Study was designed in causal-comparative research. The study was conducted with 72 s graders studying at the Department of Turkish Language Teaching at Education Faculty of Hatay Mustafa Kemal University. The Comprehension Achievement Test was employed in the study to determine reading and listening comprehension achievement scores of the students. In the study, an informative text containing 640 words and named as “Childhoods of the Famous Scientists” was used. At the end of the study it was found that Listening-Note Taking groups’ comprehension scores were statistically more successful than Reading, Reading-Note Taking and Listening groups. There was a positive-way relation determined between the students’ comprehension scores and their academic grade point averages. And in terms of gender there was no statistically significant difference between female and male students. Key words: Note taking, listening, reading, comprehension, gender, academic score.
Railroads and the Rural to Urban Transition: Evidence from 19th-Century Argentina

I provide microeconomic evidence on the role of reductions in transport costs in shaping the movement of labor out of agriculture. I exploit the expansion of the railroad network in 19th-century Argentina and individual-level longitudinal data. I construct an instrumental variable exploiting that districts along the route of province capitals were more likely to be connected. Adults in connected districts remained in farming. By contrast, their children moved out of farming toward more modern and higher paying occupations. This movement reﬂected increased outmigration and higher urbanization rates in connected districts, and was stronger in districts with low agricultural suitability. ∗ shortened version of the third chapter of my dissertation at Stanford University. I thank my advisor Ran Abramitzky, as well as Arun Chandrasekhar, Victor Lavy, Melanie Morten and Gavin Wright for outstanding guidance as part of my dissertation committee. I am grateful to Dan Bog-art, Raj Chetty, William Collins, Melissa Dell, Dave Donaldson, Pascaline Dupas, Xavier Duran, Marcel Fafchamps, James Feigenbaum, Joseph Ferrie, Price Fishback, Michela Giorcelli, Avner Greif, Caroline Hoxby, Claudia Rei, Mark Rosenzweig, Noam Yutchman and Ariell Zimran for detailed feedback. I am indebted to Stephen Redding and Pablo Fajgelbaum for sharing their GIS data on historical department borders of Argentina. I acknowledge the ﬁnancial support of the Stanford University Economics Department, the Economic History Association, the Stanford Center for International Development and the Leonard W. Ely and Shirley R. Ely Graduate Student Fund Fellowship.
CLEP_A_215399 733..741

1Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark; 2Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark; 3Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev 2730, Denmark; 4Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark Objective: The aim was to establish a large comprehensive database of patients with oral
Bone morphogenetic protein 15 induces differentiation of mesenchymal stem cell derived from human follicular fluid to oocyte like cell

Background. To study the effect of Bone morphogenetic protein 15 on differentiation potential of mesenchymal stem cell derived from human follicular fluid to oocyte like cell. Methods. Human FF derived cells were collected from 78 women in assisted fertilization program, and cultured in differentiation medium containing human recombinant BMP15 for 21 days. Mesenchymal stem cells and OLCs were characterized by real-time PCR and immunocytochemistry (ICC) staining. Results. MSCs expressed germ line stem cell markers, such as OCT4 and NANOG. After 15 days, OLCs formed and expressed zona pellucida markers (ZP2, ZP3), and reached 20 – 30 µm in diameters. Ten days after induction with BMP15, round cells remarkably developed, and the maximum size of OLCs reached 115 µm. Finally, a decrease ranging from 0.04 to 4.5 in the expression of pluripotency and oocyte specific markers was observed in the cells cultured in BMP15 supplemented medium. Our work demonstrates, FF derived MSCs have an innate potency to differentiate into OLCs, and BMP15 is effective in stimulating the differentiation of these cells, which may give an in vitro model to examine human germ cell development.
An Inconsistency in Modern Physics and a Simple Solution

In this paper, we will point out an important inconsistency in modern physics. When relativistic momentum and relativistic energy are combined with key concepts around Planck momentum and Planck energy, we find an inconsistency that has not been shown before. The inconsistency seems to be rooted in the fact that momentum, as defined today, is linked to the de Broglie wavelength. By rewriting the momentum equation in the form of the Compton wavelength instead, we get a consistent theory. This has a series of implications for physics and cosmology.