Miracle-dz/UniFAR-FTUs huggingface dataset:
Interrelationships between LGBT-based victimization, suicide, and substance use problems in a diverse sample of sexual and gender minorities

Research has documented significant relationships between sexual and gender minority stress and higher rates of suicidality (i.e. suicidal ideation and attempts) and substance use problems. We examined the potential mediating role of substance use problems on the relationship between sexual and gender minority stress (i.e. victimization based on lesbian, gay, bisexual, or transgender identity [LGBT]) and suicidality. A nonprobability sample of LGBT patients from a community health center (N = 1457) ranged in age from 19–70 years. Participants reported history of lifetime suicidal ideation and attempts, substance use problems, as well as experiences of LGBT-based verbal and physical attacks. Substance use problems were a significant partial mediator between LGBT-based victimization and suicidal ideation and between LGBT-based victimization and suicide attempts for sexual and gender minorities. Nuanced gender differences revealed that substance use problems did not significantly mediate the relationship between victimization and suicide attempts for sexual minority men. Substance use problems may be one insidious pathway that partially mediates the risk effects of sexual and gender minority stress on suicidality. Substances might be a temporary and deleterious coping resource in response to LGBT-based victimization, which have serious effects on suicidal ideation and behaviors.
Early left‐right asymmetries during axial morphogenesis in the chick embryo

The primitive node is the “hub” of early left‐right patterning in the chick embryo: (1) it undergoes asymmetrical morphogenesis immediately after its appearance at Stage 4; (2) it is closely linked to the emerging asymmetrical expression of nodal and shh at Stage 5; and (3) its asymmetry is spatiotemporally related to the emerging notochord, the midline barrier maintaining molecular left‐right patterning from Stage 6 onward. Here, we study the correlation of node asymmetry to notochord marker expression using high‐resolution histology, and we test pharmacological inhibition of shh signaling using cyclopamine at Stages 4 and 5. Just as noggin expression mirrors an intriguing structural continuity between the right node shoulder and the notochord, shh expression in the left node shoulder confirms a similar continuity with the future floor plate. Shh inhibition at Stage 4 or 5 suppressed nodal in both its paraxial or lateral plate mesoderm domains, respectively, and resulted in randomized heart looping. Thus, the “primordial” paraxial nodal asymmetry at Stage 4/5 (1) appears to be dependent on, but not instructed by, shh signaling and (2) may be fixed by asymmetrical roots of the notochord and the floor plate, thereby adding further twists to the node's pivotal role during left‐right patterning. genesis 52:614–625, 2014. © 2014 Wiley Periodicals, Inc.
Registries to measure and improve outcomes after cardiac arrest

Purpose of reviewCardiac arrest registries are used to measure and improve the process and outcome of resuscitation care, and can give insight into risk factors, prognosis, and the effectiveness of interventions to mitigate its impact. This review provides an overview of current out-of-hospital (OHCA) and in-hospital cardiac arrest (IHCA) registries, with attention to key recent findings and future directions. Recent findingsMajor OHCA registries include the Resuscitation Outcomes Consortium Cardiac Arrest Epistry and Cardiac Arrest Registry to Enhance Survival. Registry data from IHCA largely stem from the US and Canada with Get with the Guidelines-Resuscitation, and the UK with the National Cardiac Arrest Audit. Each registry has strengths and limitations. Important findings include trends in survival, racial disparities in care, and hospital and community-level variations in performance, as well as estimates of the effectiveness of individual interventions. Utstein definitions facilitate uniform reporting of the process and outcome of care, and are currently being updated. Standardization of registry data is an ongoing challenge. SummaryOHCA and IHCA registries are invaluable in advancing our understanding of resuscitation care, as well as variations in international practice. Investigations that compare and contrast outcomes from established and evolving registries will help advance resuscitation science further.
Prevalence of Hepatitis C Virus Antibodies in Italian Blood Donors

Abstract. 11,117 blood donors from 24 blood transfusion services evenly distributed throughout the various Italian regions were tested for the presence of hepatitis C virus (HCV) antibodies in the serum and serum alanine aminotransferase (ALT) level. The results are as follows: (1) anti‐HCV seroprevalence in Italy was 0.87% with a difference between Northern and Southern regions (0.68 vs. 1.37%) and between younger and older subjects (0.62 vs. 1.21%); (2) prevalence of elevated ALT levels was 4.74% without a North‐South effect (except than for markedly elevated ALT levels); (3) anti‐HCV seroprevalence was higher in subjects with elevated ALT (5.0%), with a North‐South effect (2.2 vs. 9.9%) and particularly high (19.2%) in subjects with markedly elevated ALT; (4) ALT levels were elevated in 26.2% of anti‐HCV positive subjects, with a North‐South effect (14 vs. 40.5%).
Drosophila glob1 expresses dynamically and is required for development and oxidative stress response

Summary: Biological significance of the globin protein family could be ascertained by their conservation through archaea to human. Globin(s) have been “classically” studied as oxygen binding protein(s), with recent implications in a host of other physiological functions. Drosophila melanogaster possesses three globin genes (glob1, glob2, glob3) located at different cytogenetic positions. We have performed a comprehensive investigation on the cellular expression profile and functional relevance of glob1 in Drosophila development. A profound level of maternally contributed glob1 gene products was found during early embryogenesis. Subsequently, commencement of zygotic transcription leads to its strong expression in somatic muscles, gut primordia, fat bodies, tracheal cells, etc. Similarly, dynamic expression of glob1 was evident in most of the larval tissues, interestingly with high expression in dividing cells. Reduced expression of glob1 leads to various impairments and lethality during embryogenesis and larval development. A substantial increase in level of cellular ROS was also evident due to reduced expression of glob1 which consequently leads to locomotor impairment and early aging in surviving adult flies. To best of our knowledge, this is the first report which demonstrates that in addition to oxygen management, globin gene(s) are also involved in regulating various aspects of development in Drosophila. genesis 53:719–737, 2015. © 2015 Wiley Periodicals, Inc.
Neuropilin‐2 genomic elements drive cre recombinase expression in primitive blood, vascular and neuronal lineages

We have established a novel Cre mouse line, using genomic elements encompassing the Nrp2 locus, present within a bacterial artificial chromosome clone. By crossing this Cre driver line to R26R LacZ reporter mice, we have documented the temporal expression and lineage traced tissues in which Cre is expressed. Nrp2‐Cre drives expression in primitive blood cells arising from the yolk sac, venous and lymphatic endothelial cells, peripheral sensory ganglia, and the lung bud. This mouse line will provide a new tool to researchers wishing to study the development of various tissues and organs in which this Cre driver is expressed, as well as allow tissue‐specific knockout of genes of interest to study protein function. This work also presents the first evidence for expression of Nrp2 protein in a mesodermal progenitor with restricted hematopoietic potential, which will significantly advance the study of primitive erythropoiesis. genesis 53:709–717, 2015. © 2015 Wiley Periodicals, Inc.
Ovarian polarity and cell shape determination by Btk29A in Drosophila

Drosophila Btk29A is a Tec family nonreceptor tyrosine kinase, the ortholog of which causes X‐linked agammaglobulinemia in humans when mutant. In Btk29AficP mutant ovaries, multiple defects are observed: extrapolar cells form ectopically; osk mRNA fails to accumulate posteriorly in mature oocytes; the shape and alignment of follicle cells are grossly distorted. All these phenotypes are rescued by selectively overexpressing the type 2 isoform of wild‐type Btk29A in follicle cells. Expression of certain proteins enriched in adherens junctions is markedly affected in Btk29AficP mutants; the anterior–posterior gradient normally observed in the expression of DE‐Cadherin and Armadillo are lost and Canoe is sequestered from adherens junctions. Intriguingly, tyrosine phosphorylation of Canoe is reduced in Btk29AficP mutants. It is proposed that Btk29A is required for the establishment of egg chamber polarity presumably through the regulation of subcellular localization of its downstream proteins, including Cno.
Parental Locus of Control: Associations to Adherence and Outcomes in the Treatment of Pediatric Overweight

This study examined the association of parents' locus of control (LOC) to child adherence and outcomes in a behaviorally based family treatment for pediatric overweight. A condition-specific multidimensional health LOC measure was administered to parents of 63 overweight children enrolled in a 10-week obesity treatment program. Hierarchical multiple regression analyses indicated that parents who reported a strong belief in the influence of powerful others had children who were more successful throughout treatment (p < .01). In contrast, those parents who reported that their child's outcome was due to chance had children with worse treatment outcomes (p < .05). Regarding adherence, parents with strong beliefs in chance and those who felt they were more responsible for the child's weight problem (i.e., higher parent-internal LOC) attended fewer sessions. The findings of this study lend preliminary support to the role of parental LOC in relation to the treatment of pediatric overweight. Research and clinical implications are discussed in light of the findings of this study.
Indications of Caesarean Section - Study of 100 cases in Mymensingh Medical College Hospital

This study was a prospective descriptive one. It was done in MMCH from January 1996 to march 1996. A total of 714 deliveries occurred of which 225 deliveries by Caeserean section, incidence of LSCS was 30.36%. The commonest age group of patients being operated ranged from 20 - 30 yrs (77%). Most of the patients who had undergone LSCS were multigravida (45%). The section were due to various indications, the commonest cause in this study was previous caesarean section, foetal distress and obstructed labour. The rate of primary section was more (84%) while repeat section being 16%. The peak range of operations were done in patients with 5 feet 2 inches height. The rate of elective operation was 37% . where emergency operations were done in 63% of cases. Regarding foetal outcome. 92% survived and 8% had perinatal death. DOI: http://dx.doi. org/10.3329/jssmc.v1i1. 12167 Journal of Shaheed Suhrawardy Medical College Vol.1, No.1, December 2009 p.6-10
Occipital encephalocele and hypoplastic thumb: a nonrandom association of malformations.

Summary The patient, a female, is the only child of a healthynonconsanguineous young couple. She has been followedup since 4 months of age because of congenitalnystagmus. She was born after an uneventful pregnancyby vaginal delivery at 36 weeks gestation with abirthweight of 2640g, length 46cm and head circumfer-ence 31cm. Motor and developmental milestones werewithin normal ranges. Language skills and academicperformance developed appropriate for her age. At 7years and 5 months of age, her height was 121cm (25–50centile), weight 23kg (25–50 centile) and occipitofrontalhead circumference 51.5cm (25–50 centile). No facialabnormalities were observed (Fig. 1a). A 3-cm diameterpainless nodular mass with soft tissue consistency wasobserved at the occipital vertex. The mass was reducibleon palpation, and size change also occurred during aValsalva manoeuvre. Asymmetric bilateral hypoplasticthenar eminences were noted as well as right thumbhypoplasia (Fig. 1c). A limited range of motion for activeadduction of the right thumb was also observed. She hadhorizontal nystagmus of low frequency; visual acuity was20/70 in both eyes after astigmatism correction withlenses. Ophthalmologic examination (slit-lamp biomicro-scopy, tonometry, visual field and dilated fundus exam-ination) did not reveal any further abnormalities. Nofamily history of radial defects was observed. Clinical andradiological examination of parents was normal.
Associations between psychological characteristics and indicators of metabolic syndrome among Chinese adults

Abstract Current knowledge about the relationship between psychological characteristics and metabolic syndrome (MetS) components is limited in Asian populations. The purpose of this study is to investigate linkages between physiological markers of MetS and life satisfaction, hostility, and depression in Chinese adults. Secondary analyses were conducted using cross-sectional data from parents of randomly selected middle school students participating in a pilot study in Qingdao, China. Among 440 parents who consented to participate (237 women, 203 men), 368 provided valid responses in all three categories of psychological characteristics, and only those subjects were included in these analyses. General linear models and logistic regressions were run separately by gender, controlling for covariates. Among women, life satisfaction was inversely associated with triglyceride levels (p = .04), LDL-C (p < .01), risk of hypertriglyceridemia (OR[.53], p < .01), HDL-C (OR[.78], p = .03), and MetS (OR[.52], p = .03). No associations were found between life satisfaction and any psychological characteristics among men. Among women, hostility was positively associated with triglyceride level (p = .04) and risk of hypertriglyceridemia (OR[2.12], p < .05). Among men, hostility was positively associated with waist circumference (p = .04), waist-hip ratio (p < .05), and fasting plasma insulin (p < .01). Depression was not associated with any physiological measurement in either gender. These findings indicate that relationships exist between certain psychological characteristics and physiological indicators of MetS among Chinese adults, although there may be important differences between genders.
WISC-III cognitive profiles in children with developmental dyslexia: specific cognitive disability and diagnostic utility.

This study analysed the usefulness of the Wechsler Intelligence Scale for Children-Third Edition in identifying specific cognitive impairments that are linked to developmental dyslexia (DD) and the diagnostic utility of the most common profiles in a sample of 100 Portuguese children (50 dyslexic and 50 normal readers) between the ages of 8 and 12 years. Children with DD exhibited significantly lower scores in the Verbal Comprehension Index (except the Vocabulary subtest), Freedom from Distractibility Index (FDI) and Processing Speed Index subtests, with larger effect sizes than normal readers in Information, Arithmetic and Digit Span. The Verbal-Performance IQs discrepancies, Bannatyne pattern and the presence of FDI; Arithmetic, Coding, Information and Digit Span subtests (ACID) and Symbol Search, Coding, Arithmetic and Digit Span subtests (SCAD) profiles (full or partial) in the lowest subtests revealed a low diagnostic utility. However, the receiver operating characteristic curve and the optimal cut-off score analyses of the composite ACID; FDI and SCAD profiles scores showed moderate accuracy in correctly discriminating dyslexic readers from normal ones. These results suggested that in the context of a comprehensive assessment, the Wechsler Intelligence Scale for Children-Third Edition provides some useful information about the presence of specific cognitive disabilities in DD. Practitioner Points. Children with developmental dyslexia revealed significant deficits in the Wechsler Intelligence Scale for Children-Third Edition subtests that rely on verbal abilities, processing speed and working memory. The composite Arithmetic, Coding, Information and Digit Span subtests (ACID); Freedom from Distractibility Index and Symbol Search, Coding, Arithmetic and Digit Span subtests (SCAD) profile scores showed moderate accuracy in correctly discriminating dyslexics from normal readers. Wechsler Intelligence Scale for Children-Third Edition may provide some useful information about the presence of specific cognitive disabilities in developmental dyslexia.
Relationships between work-related characteristics, needs satisfaction, motivation and mental health in midwifery students

Abstract The present study examined the relationships between work-related characteristics in internships, psychological needs satisfaction, motivation and mental health using a partial least squares path modeling. Midwifery students (N = 214; Mage = 22.8 years) from three French schools completed different questionnaires online. Results showed (1) the importance of work resources (work control and social support) as protective factors of psychological needs satisfaction; and (2) the role of competence need satisfaction through motivation in the relationships between work resources and mental health. Midwifery schools should pay more attention to these two results, and take them into account in midwifery students’ training.
Print-Tuning Lateralization and Handedness: an Event-Related Potential Study in Dyslexic Higher Education Students.

Despite their ample reading experience, higher education students with dyslexia still show deficits in reading and reading-related skills. Lateralized print tuning, the early sensitivity to print of the left parietal cortex signalled by the N1 event-related potential (ERP) component, differs between beginning dyslexic readers and controls. For adults, the findings are mixed. The present study aims to investigate whether print tuning, as indexed by the N1 component, differs between 24 students with dyslexia and 15 non-dyslexic controls. Because handedness has been linked to lateralization, first, a separate analysis was conducted including only right-handed participants (n = 12 in both groups), like in most previous studies. ERPs were measured during a judgement task, requiring visual, phonological, or semantic judgments. In both groups, the N1 was earlier and stronger in the left than in the right hemisphere. However, when only strongly right-handed participants were evaluated, the N1 was less left-lateralized for participants with dyslexia as compared with controls. Participants with dyslexia had longer reaction times during the ERP experiment and performed worse on many reading (-related) tasks. These findings suggest that abnormal print tuning can still be found among higher education students with dyslexia and that handedness should be regarded in the study of print tuning.
Increase of the Amount of Hemoglobin and Blood Volume in Connection with Physical Training

Summary. In the present paper we report on an investigation in which the amount of hemoglobin determined after the method of SJOSTRAND (1948) in a number of athletically trained men and women has been compared with that in an average group of the respective sexes. The athletically trained men and women showed considerably higher amounts of hemoglobin and blood volumes than the average material. On the whole, the best trained men deviated by 41%, and the women by 44% from the reference material. In three men and one woman the amount of hemoglobin was determined just before and immediately after a skiing tour in the mountains. The figures were 10–19 per cent higher after the training than before. In a patient who had been confined to bed for a considerable length of time (owing to fracture of the leg) the amount of hemoglobin was determined repeatedly. It showed a successive decrease, amounting at its maximum to 15 per cent of. the original figure. The amount of hemoglobin and blood volume seems accordingly to vary with the degree of physical training. The costs of the investigation have in part been defrayed by a grant from the Therese and Johan Andersson Memorial Fund.
GENETIC DIFFERENTIATION WITHOUT ISOLATION IN THE AMERICAN EEL, ANGUILLA ROSTRATA. II. TEMPORAL STABILITY OF GEOGRAPHIC PATTERNS

In an earlier report (Williams et al., 1973), we examined the problem of genetic isolation among differentiated stocks in the American eel, Anguilla rostrata. This species has an unusual life cycle, with a breeding area in the tropical Atlantic and subsequent extended larval dispersal (about 1 yr) to the shores of the Americas from Surinam to Greenland. Because of the supposed universal panmixia of this species, genetic isolation cannot exist
Everyday worry in adolescents with and without chronic pain: a diary study

Abstract Young people report frequent worry, but we know little about the extent, character, or consequence of worry in adolescence, or individual differences associated with worry. Adolescents with chronic pain are one population that are known to have high levels of anxiety, which is associated with higher levels of disability and depression, impairing function. In this study we report a diary study: adolescents (N = 60; aged 16–18) recorded their worry over seven days. Our first aim was to describe the characteristics of adolescent worry and its consequences in a community sample. Our second aim was to compare the experience of girls to boys, and to compare the experience of those with and without chronic pain. Adolescents reported characteristics of each worry they had throughout the week, including content, frequency, strength, interference, emotion, and the strength of emotion associated with worry content. Adolescents reported the consequence for each content and the strength of the consequence. Worry content and consequences were categorised into four categories; health, relationship, personal competence, and other. Adolescents reported 675 unique episodes of worry over the seven-day period that were predominantly about personal competence. The strength of worry content was (M = 6.61, SD = 1.27) and the strength associated with the worry consequence was (M = 5.59, SD = 1.41). Worries were not reported as highly interfering (M = 4.14, SD = 1.61). Contrary to predictions, there were no differences in worry characteristics between adolescents with and without chronic pain. To conclude, worry is a frequent occurrence in older adolescents and the characteristics of worry are discussed. Adolescents worry mostly about personal competence. Adolescents with and without chronic pain reported similar worry characteristics.
Beyond the phonological deficit: Semantics contributes indirectly to decoding efficiency in children with dyslexia

The present study explored the direct and indirect contribution of semantic abilities to the levels of phonological and orthographic abilities in children with dyslexia. The semantic abilities of fifty-five 9-year-old Dutch children diagnosed with dyslexia were associated with their phonological abilities (phonological awareness, rapid naming, and verbal working memory) and their word decoding and pseudoword decoding efficiency scores. It was found that children's semantic abilities predicted both word decoding efficiency and pseudoword decoding efficiency indirectly via phonological awareness and rapid naming. These results can be explained in terms of a lexical restructuring account of early reading development; strong semantic abilities provide children with dyslexia with a boost to strengthen their phonological skills and naming skills, which indirectly facilitate their reading development.