Miracle-dz/UniFAR-FTUs huggingface dataset:
A Single Dose of Beetroot Juice Does Not Change Blood Pressure Response Mediated by Acute Aerobic Exercise in Hypertensive Postmenopausal Women

Objective: To verify if acute intake of beetroot juice potentiates post-exercise hypotension (PEH) in hypertensive postmenopausal women. Methods: Thirteen hypertensive postmenopausal women (58.1 ± 4.62 years and 27.4 ± 4.25 kg/m²) were recruited to participate in three experimental sessions, taking three different beverages: Beetroot juice (BJ), placebo nitrate-depleted BJ (PLA), and orange flavored non-caloric drink (OFD). The participants performed moderate aerobic exercise training on a treadmill, at 65–70% of heart rate reserve (HRR), for 40 min. After an overnight fast, the protocol started at 07h when the first resting blood pressure (BP) was measured. The beverage was ingested at 07h30 and BP was monitored until the exercise training started, at 09h30. After the end of the exercise session, BP was measured every 15 min over a 90-min period. Saliva samples were collected at rest, immediately before and after exercise, and 90 min after exercise for nitrite (NO2−) analysis. Results: There was an increase in salivary NO2− with BJ intake when compared to OFD and PLA. A slight increase in salivary NO2− was observed with PLA when compared to OFD (p < 0.05), however, PLA resulted in lower salivary NO2− when compared to BJ (p < 0.001). There were no changes in salivary NO2− with the OFD. Systolic and diastolic BP decreased (p < 0.001) on all post exercise time points after all interventions, with no difference between the three beverages. Conclusion: Acute BJ intake does not change PEH responses in hypertensive postmenopausal women, even though there is an increase in salivary NO2−.
Toward an Improved Air Pollution Warning System in Quebec

The nature of pollutants involved in smog episodes can vary significantly in various cities and contexts and will impact local populations differently due to actual exposure and pre-existing sensitivities for cardiovascular or respiratory diseases. While regulated standards and guidance remain important, it is relevant for cities to have local warning systems related to air pollution. The present paper proposes indicators and thresholds for an air pollution warning system in the metropolitan areas of Montreal and Quebec City (Canada). It takes into account past and current local health impacts to launch its public health warnings for short-term episodes. This warning system considers fine particulate matter (PM2.5) as well as the combined oxidant capacity of ozone and nitrogen dioxide (Ox) as environmental exposures. The methodology used to determine indicators and thresholds consists in identifying extreme excess mortality episodes in the data and then choosing the indicators and thresholds to optimize the detection of these episodes. The thresholds found for the summer were 31 μg/m3 for PM2.5 and 43 ppb for Ox in Montreal, and 32 μg/m3 and 23 ppb in Quebec City. In winter, thresholds found were 25 μg/m3 and 26 ppb in Montreal, and 33 μg/m3 and 21 ppb in Quebec City. These results are in line with different guidelines existing concerning air quality, but more adapted to the cities examined. In addition, a sensitivity analysis is conducted which suggests that Ox is more determinant than PM2.5 in detecting excess mortality episodes.
Clustering of IRE1α depends on sensing ER stress but not on its RNase activity

The sensors of the unfolded protein response react to endoplasmic reticulum (ER) stress by transient activation of their enzymatic activities, which initiate various signaling cascades. In addition, the sensor IRE1α exhibits stress‐induced clustering in a transient time frame similar to activation of its endoRNase activity. Previous work had suggested that the clustering response and RNase activity of IRE1α are functionally linked, but here we show that they are independent of each other and have different behaviors and modes of activation. Although both clustering and the RNase activity are responsive to luminal stress conditions and to depletion of the ER chaperone binding protein, RNase‐inactive IRE1α still clusters and, conversely, full RNase activity can be accomplished without clustering. The clusters formed by RNase‐inactive IRE1α are much larger and persist longer than those induced by ER stress. Clustering requires autophosphorylation, and an IRE1α mutant whose RNase domain is responsive to ligands that bind the kinase domain forms yet a third type of stress‐independent cluster, with distinct physical properties and half‐lives. These data suggest that IRE1α clustering can follow distinct pathways upon activation of the sensor. —Ricci, D. , Marrocco, I. , Blumenthal, D. , Dibos, M. , Eletto, D. , Vargas, J., Boyle, S. , Iwamoto, Y. , Chomistek, S. , Paton, J. C. , Paton, A. W. , Argon, Y. Clustering of IRE1α depends on sensing ER stress but not on its RNase activity. FASEB J. 33, 9811–9827 (2019). www.fasebj. org
Thermal annealing of exfoliated graphene

Monolayer graphene is obtained bymechanical exfoliation using scotch tapes. The effects of thermal annealing on the tape residues and edges of graphene are researched. Atomic force microscope images showed that almost all the residues could be removed in N2/H2 at 400°C but only agglomerated in vacuum. Raman spectra of the annealed graphene show both the 2D peak and G peak blueshift. The full width at halfmaximum (FWHM) of the 2D peak becomes larger and the intensity ratio of the 2D peak to G peak decreases. The edges of graphene are completely attached to the surface of the substrate after annealing.
Aerothermodynamic Optimization of Aerospace Plane Airfoil Leading Edge

Aiming to mitigate the aerodynamic heating during hypersonic re-entry, the aerothermodynamic optimization of aerospace plane airfoil leading edge is conducted. Lift-todrag ratio at landing condition is taken as a constraint to ensure the landing aerodynamic performance. First, airfoil profile is parametrically described to be more advantageous during the optimization process, and the Hicks-Henne type function is improved considering its application on the airfoil leading edge. Computational Fluid Dynamics models at hypersonic as well as landing conditions are then established and discussed. Design of Experiment technique is utilized to establish the surrogate model. Afterwards, the previously mentioned surrogate model is employed in combination with the Multi-Island Genetic Algorithm to perform the optimization procedure. NACA 0012 is taken as the baseline airfoil for case study. The results show that the peak heat flux of the optimal airfoil during hypersonic flight is reduced by 7.61% at the stagnation point, while the lift-to-drag remains almost unchanged under landing condition.
Socio-affective and cognitive predictors of social adaptation in vulnerable contexts

People living in vulnerable environments face a harder set of challenges adapting to their context. Nevertheless, an important number of them adapt successfully. However, which cognitive and socio-affective variables are specifically related to these variations in social adaptation in vulnerable contexts has not been fully understood nor directly addressed. Here we evaluated socio-affective variables (anxious attachment style, internal locus of control, self-esteem and stress) and cognitive variables (fluid intelligence, crystallized intelligence, working memory, numeracy, probabilistic reasoning and logical reasoning) to explain variations in social adaptation in a sample of 232 adults living in vulnerable contexts (M = 42.3, SD = 14.9, equal amount of men and women). Our results show that an important amount of variance in social adaptation can be explained by socio-affective variables, principally by self-esteem, while cognitive variables also contributed significantly. As far as we know, this is one of the first steps towards understanding the role of cognitive and socio-affective features on social adaptation. In the long run, this area of research could play an important role on the assignation of resources to ease people’s integration into society. Our data and R analysis scripts can be found at: https://osf.io/egxy5/.
High Frequency Traders: Taking Advantage of Speed

We propose a model of dynamic trading where a strategic high frequency trader receives an imperfect signal about future order flows, and exploits his speed advantage to optimize his quoting policy. We determine the provision of liquidity, order cancellations, and impact on low frequency traders as a function of both the high frequency trader's latency, and the market volatility. The model predicts that volatility leads high frequency traders to reduce their provision of liquidity. Finally, we analyze the impact of various policies designed to potentially regulate high frequency trading.
MONOGRAPHIC STUDY OF PLANT SPECIES MOST USED FOR TREATMENT OF COMMON DISEASES OF SOMBA CATTLE IN BENIN

To face the common ailments of Somba cattle in it natural area, some breeders use endogenous methods based herbal. The present study is a monography of the most used plants in order to appropriate all the literature that exists on these plants before eventually begin experimental studies for scientific validation of their therapeutic effects. For each plant species, the study examined the following data: the botanical description, geographical and ecological distribution, chemical composition, pharmacological uses, and other uses. It basically shows that the study of medicinal uses mentioned by the Somba cattle plants are widely reported by many other authors in various African, Asian and Latin American countries, but much more in human medicine than in veterinary medicine. The predominance of compounds pharmacological properties reported in the chemical compositions by different studies also confirmed the therapeutic capabilities of these plants. By cons, very few of the pharmacological and therapeutic properties have been described scientifically proven. Keywords: monography-plants-diseases-somba cattle
First Case Report of Primary Carnitine Deficiency Manifested as Intellectual Disability and Autism Spectrum Disorder

Systemic primary carnitine deficiency (PCD) is a genetic disorder caused by decreased or absent organic cation transporter type 2 (OCTN2) carnitine transporter activity, resulting in low serum carnitine levels and decreased carnitine accumulation inside cells. In early life, PCD is usually diagnosed as a metabolic decompensation, presenting as hypoketotic hypoglycemia, Reye syndrome, or sudden infant death; in childhood, PCD presents with skeletal or cardiac myopathy. However, the clinical presentation of PCD characterized by autism spectrum disorder (ASD) with intellectual disability (ID) has seldom been reported in the literature. In this report, we describe the clinical features of a seven-year-old girl diagnosed with PCD who presented atypical features of the disease, including a developmental delay involving language skills, concentration, and attention span, as well as autistic features and brain alterations apparent in magnetic resonance imaging. We aim to highlight the difficulties related to the diagnostic and therapeutic approaches used to diagnose such patients. The case reported here presented typical signs of PCD, including frequent episodes of hypoglycemia, generalized muscle weakness, decreased muscle mass, and physical growth deficits. A molecular genetic study confirmed the definitive diagnosis of the disease (c.1345T>G (p.Y449D)) in gene SLC22A5, located in exon 8. PCD can be accompanied by less common clinical signs, which may delay its diagnosis because the resulting global clinical picture can closely resemble other metabolic disorders. In this case, the patient was prescribed a carnitine-enriched diet, as well as oral carnitine at a dose of 100 mg/kg/day. PCD has a better prognosis if it is diagnosed and treated early; however, a high level of clinical suspicion is required for its timely and accurate diagnosis.
Methods to Compare Dissolution Profiles*

The objective of this work was to apply several profile comparison approaches to dissolution data of four different Metoprolol tartrate tablet formulations in order to quantify each method's metric for comparing dissolution profiles. Dissolution was performed using the United States Pharmacopeia (USP) monograph method on four formulations of metoprolol tartrate tablets. Two general approaches to compare dissolution profiles were examined: model-independent approaches and model-dependent approaches. The model-independent methods included ANOVA-based procedures, ratio test procedures, and pair-wise procedures. The model-dependent approaches included zero-order, first-order, Hixson-Crowell, Higuchi, quadratic, Weibull, Gompertz, and logistic models. It is concluded that the ratio test procedures, the pair-wise procedures, and several model-dependent approaches yielded numerical results which can possibly serve as objective and quantitative metrics for comparing entire dissolution profiles of the four metoprolol tartrate formulations.
“The dog and the carrot are both useful to me”: Functional, self-referent categorization in rural contexts of scarcity in the Dominican Republic.

Categorization by individuals living in different settings within a culture or nation has received little attention. The current study was designed to reveal the categorization styles and reasoning of 2 groups of participants living in the Dominican Republic. One group of 32 participants was from an urban setting with abundant resources; the second group of 44 participants lived in a rural setting with scarce resources. Rural participants were significantly more likely than their urban counterparts to categorize objects in a functional, self-referent way, for example, “The dog and the carrot are both useful to me. ” Regression analysis showed that the interaction between education and setting predicted functional categorization. In the urban abundance setting more education was associated with fewer functional categorizations. The functional style of categorization may be a unique extension of holistic thinking that is adaptive in certain ecological niches.
Maternal Leucine-Rich Diet Minimises Muscle Mass Loss in Tumour-bearing Adult Rat Offspring by Improving the Balance of Muscle Protein Synthesis and Degradation

Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich diet treatment improved muscle protein turnover by modifying the mTOR and proteolytic pathways, thus we analysed whether maternal supplementation could ameliorate muscle protein turnover in adult offspring tumour-bearing rats. Pregnant Wistar rats received a control diet or 3% leucine-rich diet during pregnancy/lactation, and their weaned male offspring received a control diet until adulthood when they were distributed into following groups (n = 7–8 per group): C, Control; W, tumour-bearing; L, without tumour with a maternal leucine-rich diet; and WL, tumour-bearing with a maternal leucine-rich diet. Protein synthesis and degradation were assessed in the gastrocnemius muscle, focusing on the mTOR pathway, which was extensively altered in W group. However, the WL adult offspring showed no decrease in muscle weight, higher food intake, ameliorated muscle turnover, activated mTOR and p70S6K, and maintained muscle cathepsin H and calpain activities. Maternal leucine nutritional supplementation could be a positive strategy to improve muscle protein balance in cancer cachexia-induced muscle damage in adult offspring rats.
Political and Business Leaderships in Managing Public Service Organisation

This study analyses the relationship between the state’s political ideologies and the implementation of cost management strategies during the re-privatisation of a public sector organisation. Drawing on the Dillard et al.’s (2004) conceptual framework, we conducted a case study in a public sector organisation operating in the electricity market of Egypt. Data was gathered through document analysis, interviews, meetings observations and continuous interactions with key informants from 2013 to 2014. The findings show that the implementation of cost management strategies had a political basis, grounded in the state’s reformative ideologies concerning re-privatisation of the public sector organisation. The re-privatisation failed because the state failed to convince a potential international investor. A theoretical contribution is to show the relevance of cost management strategies when used as a political tool to achieve a business goal, such as improving a public sector organisation’s performance management in a developing country. This is the first empirical case study to analyse management accounting change based on the state’s political ideologies in the Maghreb region of Africa. The key difference between this global trend elsewhere and in the Egyptian State, as in some other Islamic countries, is that Egypt was both nationalistic and militarised.
Norms of quantum Gaussian multi-mode channels

We compute the $\mathcal S^p \to \mathcal S^p$ norm of a general Gaussian gauge-covariant multi-mode channel for any $1\leq p<\infty$, where $\mathcal S^p$ is a Schatten space. As a consequence, we verify the Gaussian optimizer conjecture and the multiplicativity conjecture in these cases.
Significance of degree of neurovascular compression in surgery for trigeminal neuralgia.

OBJECTIVE The aim of this study was to identify preoperative imaging predictors of surgical success in patients with classic trigeminal neuralgia (cTN) undergoing microvascular decompression (MVD) via retrospective multivariate regression analysis. METHODS All included patients met criteria for cTN and underwent preoperative MRI prior to MVD. MR images were blindly graded regarding the presence and severity (i.e., mild or severe) of neurovascular compression (NVC). All patients were contacted by telephone to determine their postoperative pain status. RESULTS A total of 79 patients were included in this study. Sixty-two patients (78.5%) were pain-free without medication following MVD. The following findings were more commonly observed with the symptomatic nerve when compared to the contralateral asymptomatic nerve: NVC (any form), arterial compression alone, NVC along the proximal trigeminal nerve, and severe NVC (p values < 0.0001). The only imaging variable that was a statistically significant predictor of being pain-free without medication following MVD was severe NVC. Patients with severe NVC were 6.36 times more likely to be pain-free following MVD compared to those without severe NVC (p = 0.007). CONCLUSIONS In patients with cTN undergoing MVD, severe NVC on preoperative MRI is a strong predictor of an excellent surgical outcome.
MINIMIZATION OF UNSATURATED FATTY ACID HYDROGENATION IN RUMENT WITH KAFFIR LIME (Citrus hystrix) LEAVES

This research aimed to know the ability of C. hystrix to protect unsaturated fatty acid on the hydrogenation process by rumen microbes. Cooking oil was tested to determine the fat profile,then mixed with skim milk (1:2). The mixture were added by C. hystrix leaves powder with the level of 0%, 1%, 2%, 3% and 4% (dry weight bases) from the weight of the mixture, then mixed evenly to form protected cooking oil. The oil was added into a syringe, containing 300 mg of feed substrates, elephant grass and bran= 60:40, then added with 30 ml of rumen fluid and buffer mixture. The syringe was incubated at 39oC for 48 hours. The data was analyzed by completely random design. The difference of means the treatments were tested by Duncan’s new multiple range test. Result showed that oleic and linoleic content resulted from fermentation of cooking oil protected by C. hystrix leaves powder was increase compared to unprotected. It can be concluded that cooking oil protected with C. hystrix leaves powder reduced hydrogenation of unsaturated fatty acid, mainly oleic and linoleic. (
Idiopathic thrombocytopenic purpura (ITP) – new era for an old disease

Abstract Immune thrombocytopenia is an autoimmune hematological disorder characterized by severely decreased platelet count of peripheral cause: platelet destruction via antiplatelet antibodies which may also affect marrow megakaryocytes. Patients may present in critical situations, with cutaneous and/or mucous bleeding and possibly life-threatening organ hemorrhages (cerebral, digestive, etc.) Therefore, rapid diagnosis and therapeutic intervention are mandatory. Corticotherapy represents the first treatment option, but as in any autoimmune disorder, there is a high risk of relapse. Second line therapy options include: intravenous immunoglobulins, thrombopoietin receptor agonists, rituximab or immunosuppression, but their benefit is usually temporary. Moreover, the disease generally affects young people who need repeated and prolonged treatment and hospitalization and therefore, it is preferred to choose a long term effect therapy. Splenectomy – removal of the site of platelet destruction – represents an effective and stable treatment, with 70–80% response rate and low complications incidence. A challenging situation is the association of ITP with pregnancy, which further increases the risk due to the immunodeficiency of pregnancy, major dangers of bleeding, vital risks for mother and fetus, potential risks of medication, necessity of prompt intervention in the setting of specific obstetrical situations – delivery, pregnancy loss, obstetrical complications, etc. We present an updated review of the current clinical and laboratory data, as well as a detailed analysis of the available therapeutic options with their benefits and risks, and also particular associations (pregnancy, relapsed and refractory disease, emergency treatment).
A Social Networks Approach to Understanding Vaccine Conversations on Twitter: Network Clusters, Sentiment, and Certainty in HPV Social Networks

ABSTRACT Individuals increasingly rely on the Internet, and social media in particular, for health-related information. A recent survey reports that 80% of Internet users search for health information online. In the present study, we employ Twitter data to understand content characteristics and the patterns of content flow of the conversations about the HPV vaccine debate. Approaching the HPV vaccine conversations on Twitter as a social network, we can identify key self-formed subgroups—clusters of users who create “siloes” of interactions and information flow. Combining network analysis, computer-aided content analysis, and human-coded content analysis, we explored the communication dynamics within the groups in terms of group members’ affective and cognitive characteristics. Our findings show that positive emotion is positively correlated with cluster density, an indicator of strong ties and rapid information flow. In the case of negative emotion, we found that anger is a significant negative predictor for graph density. We also found a correlation between certainty and tentativeness; both at cluster as well as at tweet level, suggesting that clusters bring together people who are sure about the HPV vaccine and people who are exploring for answers.