Miracle-dz/UniFAR-FTUs huggingface dataset:
The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42

Rationale: As a component of GINS complex, GINS4 is essential for initiating DNA replication and elongation of the cell cycle G1/S phase in eukaryotes and plays a vital role in normal physiological processes. However, the precise functions and regulation mechanisms of GINS4 in human tumors remain elusive. Methods: GINS4 expression was analyzed in gastric cancer tissues by qRT-PCR and western blotting, and its clinical relevance was studied using TMA. The biological functions of GINS4 were detected in vitro and in vivo. cDNA array, co-IP, GST pull-down and GTPase activation assays were performed to investigate the downstream regulation mechanism of GINS4. Upstream regulation mechanism of GINS4 was explored and demonstrated by circRNA sequencing, bioinformatics analysis, luciferase reporter assay and rescue experiments. Results: Strikingly high GINS4 expression was detected in gastric cancer tissues and correlated with poor differentiation, advanced tumor stage, invasion depth and lymph node metastasis. GINS4 promoted cell growth and metastasis in vitro and in vivo, and suppressed cell apoptosis in vitro. Mechanistically, GINS4 activated Rac1/CDC42 through directly binding to Rac1/CDC42, thereby activating their downstream pathways. Furthermore, circMLLT10 acts as a miR-509-3-5p sponge to attenuate its repressive effect on target GINS4. In addition, circMLLT10 promoted cell growth and metastasis and suppressed cell apoptosis, whereas miR-509-3-5p inhibited cell growth and metastasis and promoted cell apoptosis. Conclusion: The findings indicate for the first time that the novel GINS4 axis promotes gastric cancer cell growth and progression by activating Rac1 and CDC42. GINS4 may be a promising biomarker and target for diagnosis and treatment of gastric cancer.
Diagnostic accuracy of transrectal elastosonography (TRES) imaging for the diagnosis of prostate cancer: a systematic review and meta‐analysis

Aboumarzouk et al . provide a comprehensive overview of transrectal elastosonography (TRES), sometimes simply referred to as elastography, in the diagnosis of prostate cancer. This represents a relatively new method in the detection of prostate cancer with the potential for further development. The current ‘ gold standard ’ prostate biopsy based upon standard grey-scale TRUS imaging is limited due to the highly variable appearance of prostate cancer, and the challenges of distinguishing benign from malignant tissue with grey-scale or colour Doppler [ 1 ] . There is a notable improvement in the Doppler detection of prostate cancer with microbubble contrast agents. Hypervascular prostate cancers are detected with fewer biopsy cores by using microbubble contrast-enhanced US (CEUS) with higher grade cancers more likely to be detected with the CEUS than with other TRUS methods [ 1,2 ] .
Sociodemographic and Clinical Features of Obsessive Compulsive Disorder in a Large Sample of Children and Adolescents from Turkey

Objective: Obsessive compulsive disorder (OCD) is a time-consuming and chronic disorder characterized by obsessions and compulsions that can start before age of eighteen and can be associated with significant impairments in academic, social and family functioning. In this study, our aim was to evaluate sociodemographic characteristics, clinical pictures and comorbid diagnoses of a large sample of children and adolescents who were diagnosed with OCD according to diagnostic criteria of DSM-IV-TR in a child and adolescent psychiatry outpatient clinic of a University Hospital. Methods: Patients who were first diagnosed at the study center with OCD according to DSM-IV-TR criteria were included. For inclusion, the primary diagnosis should be OCD as per DSM-IV-TR criteria and there must be concordance between at least 2 clinicians (one resident and the head of department) for diagnosis. Results: 440 cases were included in our study and the most common obsessions in our sample were contamination with dirt (48.8%), and exactness (23.8%) and most common compulsions were ordering/checking (42.4%) and washing/cleaning (32.0%). Most of the patients in our sample (78.0%) had a comorbid diagnosis and most common comorbidities were AttentionDeficit/ Hyperactivity Disorder (26.6%) and Generalized Anxiety Disorder (20.5%). Discussion: Accordingly, our results in terms of comorbidity, obsessions and compulsions are consistent with the literature. In conclusion, this is the largest study on a clinical sample of pediatric OCD from Turkey that we are aware of in terms of sample size, time frame and statistical power.
Parametrised Algorithms for Finding Triangles in Graphs

Detecting, counting and enumerating triangles in graphs is a simple yet frequently required task. It is well known to be solvable in O(n ·m) time on graphs with n vertices and m edges. This thesis contributes to the relatively young field of FPT in P which is motivated by the question which parametrisations can be used to solve problems that are already known to be solvable in polynomial time faster in relevant special cases. We will give both positive and negative answers to this question regarding problems of finding triangles. On the one hand, we construct algorithms and kernelisations for finding triangles in graphs having constantly bounded parameter values in linear time for certain parametrisations. On the other hand, we introduce a new notion of hardness which we use to prove that certain parametrisations cannot be used to design algorithms that are faster than the best known unparametrised algorithms. Among other things, we will show that all triangles in a graph can be enumerated in O(n · k) time, where k is the degeneracy of the graph. Moreover, we will prove that counting all triangles in a graph cannot be done faster on three-colourable graphs or graphs with maximum diameter of components at least two than on arbitrary graphs. These bounds are tight as counting all triangles on bipartite (two-colourable) graphs or graphs with maximum diameter of components one, that is cluster graphs, can be done in linear time.
Nephroprotective and Antioxidant Effects of Moringa Oleifera (Sohanjna) in Paracetamol Induced Nephrotoxic Albino Rabbits

Received: Revised: Accepted: Published online: April 27, 2015 March 26, 2016 April 08, 2016 June 29, 2016 In present study nephroprotective and antioxidant effects of Moringa oleifera were investigated in paracetamol induced nephrotoxic albino rabbits. Thirty-six healthy adult albino rabbits randomly divided into six equal groups were provided with normal routine feed and drinking water. Except untreated control group-1, the rest of the groups administered orally with 500 mg/kg paracetamol as nephrotoxic drug for 0-15 days. Group-II served as untreated control on paracetamol only and groupIII as treated control on synthetic nephroprotective drug, silymarin 150 mg/kg orally. M. oleifera seed powder was given orally to treated groups-IV, V and VI at dose rate of 200, 400 and 600 mg/kg body weight, respectively. Blood samples were collected at 0 and 15 days. At the termination of experiment, rabbits were slaughtered and kidney tissues were excised for histopathological examination. Data were compared statistically by Duncan’s DMR test at 5% level of significance. The results suggested that paracetamol induced renal damage significantly (P<0.05) increased the levels of serum creatinine (Cr), blood urea nitrogen (BUN), total oxidant status (TOS) and malondialdehyde (MDA). However, catalase (CAT) and total antioxidant capacity (TAC) were significantly (P<0.05) decreased along with histopathological necrotic damage of renal tissues in nephrotoxic rabbits. M. oleifera seed powder, at the dose rate of 600 mg/kg, exhibited nephroprotective and antioxidant effects through biochemical and histological protections against paracetamol induced renal damage in albino rabbits. This indicates that M. oleifera seed powder at the dose rate of 600 mg/kg is as efficacious as silymarin in exerting nephroprotective and antioxidant effects. ©2016 PVJ. All rights reserved
Early pregnancy vitamin D deficiency and gestational diabetes: Exploring the link.

BACKGROUND AND OBJECTIVES Diabetes, including gestational diabetes mellitus (GDM), and vitamin D deficiency or insufficiency (VDDI) are recognised public health problems. There is conflicting evidence regarding the relationship between vitamin D deficiency and GDM. The aim of this study was to explore the incidence of VDDI among pregnant women attending a maternity unit in Sydney, Australia, and the relationship between VDDI in early pregnancy and later development of GDM. METHOD This was a prospective cohort study in which 25-hydroxyvitamin D was measured in pregnant women during 2011-13. Exclusion criteria included pre existing diabetes, bowel disease and reduced cognitive ability. RESULTS There were 785 women enrolled in the study and 42 excluded. Findings from this study did not show an association between VDDI in early pregnancy and development of GDM. Important predictors of GDM remained the well known risk factors: family history, ethnicity, body mass index and age. DISCUSSION Clinical conversations should continue to focus on proven modifiable factors such as weight management and the provision of timely testing appropriate to the risk identified through history-taking.
PEP Web-Introduction: A Systems View

Our goal in this series of four papers is a further refinement of a theory of interaction for psychoanalysis, with a specific focus on the concept of intersubjectivity. Psychoanalysis has addressed the concept of intersubjectivity primarily in the verbal/explicit mode. In contrast, infant research has addressed the concept of intersubjectivity in the nonverbal/ implicit mode of action sequences, or procedural knowledge. We propose that an integration of explicit/linguistic with implicit/nonverbal theories of intersubjectivity is essential to a deeper understanding of therapeutic action in psychoanalysis today. To shed light on an implicit/nonverbal
BARRIERS TO THE USE OF INTERNET BANKING AMONG NIGERIAN AND ZIMBABWEAN STUDENTS IN NORTHERN CYPRUS

Bu makalenin amaci Kuzey Kibris’ ta bulunan Nijeryali ve Zimbabveli universite ogrencilerinin internet bankaciligi servislerini kullanmalarina engel olan faktorleri arastirmaktir. Veri toplamak icin Kuzey Kibris’ta ozel bir universitede bulunan yuz Nijeryali ve yuz Zimbabveli ogrenciye anket verilmistir. Faktor analizi sonuclarina g o re Nijeryali ve Zimbabveli universite ogrencilerinin internet bankaciligi kullanmalarini engelleyen en onemli faktor internet bankaciligini kullanmayla ilgili hissettikleri risktir. Bunu sirasiyla ogrencilerin geleneksel bankacilik servislerini tercih etmeleri engeli, internet bankaciligi kullanisliligiyla ilgili algilamalar engeli, altyapi engeli, devletten kaynaklanan engeller ve kisisel kapasite engelleri takip etmektedir. Yukarida bahsedilen faktorlerin Nijeryali ve Zimbabveli universite ogrencileri arasinda farkliliklarini bulmak icin, bagimsiz orneklemeler t-testi kullanilmistir. Arastirmanin bulgulari Zimbabveli ve Nijeryali ogrenciler arasinda geleneksel bankacilik servislerini tercih etmeleri engeli, altyapi engeli, ve devletten kaynaklanan engeller bakimindan istatistiksel olarak anlamli bir farklilik oldugunu gostermektedir. Ilginc olarak, Zimbabveli ve Nijeryali ogrencilerin internet bankaciligini kullanmayla ilgili hissettikleri risk, internet bankaciligi kullanisliligiyla ilgili algilamalar engeli ve kullanim engelleri arasinda istatistiksel olarak anlamli bir fark yoktur.
Long-term impacts of mid-Holocene drier climatic conditions on Bolivian tropical dry forests

Abstract The Bolivian Chiquitano dry forest is the largest block of intact seasonally dry tropical forest in South America and is a priority ecoregion for conservation due to its high threat status. However, the long-term impacts of drier climatic conditions on tropical dry forests are not well understood, despite climate models predicting increased droughts over Bolivia in the coming century. In this paper, we assess the impacts of drier climatic conditions during the mid-Holocene on the Bolivian Chiquitano tropical dry forest using fossilised pollen, phytoliths, macro-charcoal, and geochemical proxies from a sediment core from a large lake (Laguna Mandioré) on the Bolivia–Brazil border. Our results show that drier climatic conditions during the mid-Holocene caused a local-scale, ecotonal expansion of upland savannah at the expense of dry forest. Interaction between drier climatic conditions and fire regime likely exerted a stronger control over the position of the dry forest–savannah ecotone than edaphic factors. However, the majority of the dry forest within the lake catchment maintained a closed canopy throughout the drier conditions of the mid-Holocene, despite floristic turnover towards more drought-tolerant taxa. These findings imply overall resilience of the Chiquitano dry forest biome to future drought, albeit with floristic changes and upland savannah encroachment at ecotones.
The Impact of Organization Forgetting and Organization Culture on Knowledge Management in Electro Manufacture Industry

The electro manufacturing industry continues to grow in Indonesia. This study aims to find causal effect of organization forgetting and organizational culture relationships with knowledge management. This study uses a quantitative approach. The questionnaire in this study will be distributed to 338 employees engaged in the electro manufacturing industry. Data will be processed using an analysis tool, SPSS. The results of this study show that organizational forgetting affects knowledge management significantly and positively. Organizational culture has a significant and positive influence on knowledge management
Phytochemical Analysis and Mineral Content of Ethanol Extract of Citrullus lanatus Bark

This study examined the phytochemical and elemental content of water melon (Citrullus lanatus) bark. The sample was spread in the laboratory to dry at room temperature after which it was grounded to get a coarse powder form using sterile mortar and pestle. The extracts (ethanol and aqueous) were subjected to phytochemical and elemental analysis using standard procedures. Qualitative phytochemical screening of the ethanol extract revealed the presence of tannins, alkaloid, saponins, oxalates, flavonoids, steroid, phytates and glycoside while the quantitative phytochemical screening indicated the contents of tannins to be (1.360g/100g), alkaloid (3.965 g/100g), saponins (1.380 g/100g), oxalates (3.675 g/100g), flavonoids (1.145g/100g), steroid (1.080g/100g), phytates (3.160g/100g) and glycoside (4.490 g/100g). The elemental analysis showed that the extracts contains Ca (0.025±0.002mg/100g), K (0.065±0.001mg/100g), Fe (0.189±0.007mg/100g), Zn (0.263±0.005mg/100g), Mg (1.771±0.005 mg/100g), Mn (0.670 ±0.003mg/100g), Na (0.033±0.001mg/100g), and Cu (0.245±0.003mg/100g) however Cr was not detected. The results of this study showed that the ethanol extract of C. lanatus contain bioactive compounds which might be responsible for pharmacological actions of the plant and the plant can also serve as a source of mineral elements in diet.
Effect of Pre-Sowing Treatments on Seed Germination of Tectona grandis

A nursery based experiment was conducted to study the effect of varied pre-sowing treatments on seed germinations of Tectona grandis (Teak). Seeds of selected species were subjected to six different pre-sowing treatments. Results revealed that, the highest germination percentage was observed 86.67% in Pith method, followed by 73.33% in soaking in normal water (72 hours) and 45% in soaking in normal water (24 hours). The highest germination value was found in T4 (21.82) followed by T3 (13.52), 8.37 in T5 (immersion in 80% concentrated H2SO4 for 20 minutes). Our result finds that pre-sowing treatment is obviously better than control. Pit method and soaking in normal water for 72 hours are highly recommended for maximum germination within the shortest period of time. These findings of the research will be helpful to take effective decision regarding the raising of large scale production of Tectona grandis (Teak) seedling in a cost effective way with ensuring their earlier germination.
Tympanostomy Tube Placement for Otitis Media with Effusion in Children with Cleft Lip and Palate

The condition of cleft lip/palate (CLP) in children is psychologically stressful for family members and debilitating for the patients themselves. These children must undergo a series of major invasive surgeries following birth, including cleft lip repair surgery, cleft palate repair surgery, bone grafting surgery, and dental implant surgery. Unfortunately, the clinical significance of otitis media with effusion (OME), a complication associated with CLP, is often overlooked, and very few studies have explored this condition in depth. This chapter reviews pathogenesis, clinical manifestations, consequences, exami‐ nation, and diagnosis related to OME in children with CLP. Controversies surrounding the treatment of OME in CLP children are also discussed. We also provide a flowchart for management guidance in OME in children with CLP.
Minimal cost production of banana (Musa spp.) using modified MS medium in vitro and acclimatization in hydroponics system ex vitro

In vitro production of banana at low cost and acclimatization of plantlets using hydroponics system in the greenhouse were studied. Hydroponics system allows for higher accuracy in terms of controlling the surrounding environmental conditions, which then allows for a higher possibility of increasing productivity and enhancing the quality of plants. Increased number of vigorous shoots produced in modified MS could be mainly due to the synergistic effect of enhancing the elements on improving the metabolic activities in shoot initiation and development. Cytokinin helps in shoot proliferation, and increasing of minerals which plays a significant role in shoot growth and development. Of the different MS medium, the best response in terms of roots number attained with M5 and M6. The relative humidity in the hydroponic system provided a consistent decrease, allowing the gradual acclimatization of the regenerated plants to the unique environment compared to greenhouse potted plants. Hydroponic system which turned to be the best and lowest cost of acclimated of banana during current study. Plant growth parameters in terms of maximum root number, leaves number, plant length, stem diameter and increased weight occurred when plants were adapted and kept in hydroponics. Analysis of the results has shown that the survival rate and growth vigor was higher in plants grown hydroponically as opposed to their traditionally grown ones. Response to the nutrient medium used was also encouraging in the hydroponically grown plantlets.
Application of Essential Oils: Lavender, Clary Sage, Ginger and Geranium as Aromatherapy through Effleurage Massage for Menstrual Pain

Menstrual pain is pain that is felt in the pelvis, lower abdomen, lower back, severe lower abdominal cramps, pain that occurs before or during menstruation. This study used true experimental design, and pretest-post-test design with a simple random sampling technique. Treatment group was given aromatherapy lavender, clary sage, Ginger, geranium with a ratio of 1: 1: 1: 1 with a final concentration of 4% mixed with almond oil through massage effleurage and Treatment II was given aromatherapy lavender concentration of 1% mixed with almond oil. Changes pain intensity are measured using a Numerical Rating Scale. Results: Based on the Mann Whitney test results obtained between the treatment group I and treatment group II with p-value = 0.001 means that there was a significant difference in the decrease in pain intensity in the groups given essential oils: lavender, clary sage, ginger, geranium with a concentration of 4% mixed with almond oil through massage effleurage and groups that were only given lavender oil 1% and mixed with almond oil through massage effleurage. Lavender, clary sage, ginger and geranium essential oils mixed with almond oil through massage effleurage are more effective in decreasing pain intensity than those who were only given lavender oil.
Assessing the competitiveness of locations: A journey through the major theoretical insights

Abstract The concept of competitiveness has been addressed by economic theorists and policy makers for several hundreds of years, with both groups trying to understand the drivers of economic prosperity and social welfare. This contribution does not aim to address all theoretical thoughts that may contribute to understanding the roots of the competitiveness of locations. The goal is to address the major useful theoretical contributions that permit to identify the main drivers of a territory’s competitiveness and therefore to assess the competitiveness of a specific location according to strong criteria. The first section presents the major contributions found in the classical and neo-classical theories. The second section and the third section concentrate on two majors schools providing significant thoughts on the competitiveness of locations: the Economic Geography (EG) School and the International Business (IB) School.
A PRISMA-compliant meta-analysis

Background: To evaluate if splenectomy results in severely impaired immune responses against primary cytomegalovirus (CMV) infection compared to the general immunocompetent population. Methods:We performed a systemic literature review to study CMV infections in splenectomized individuals, a special population group presently considered immunocompetent to viral infections. We retrieved 30 cases with established CMV infection postsplenectomy and we recorded their disease manifestations, laboratory findings, immunological studies, and histopathology reports. In addition, we retrieved numerous multidisciplinary articles in view of post-splenectomy immunology defects, as well as of immune responses to primary invading CMV in the absence of the spleen. Two clinical studies directly comparing splenectomized with nonsplenectomized individuals under severe iatrogenic immunosuppression as well as the numerically largest review articles of CMV infections in immunocompetent were retained. Results: Splenectomy results in the loss of spleen’s ability to fend-off blood-borne pathogens and impairs the link between innate and adaptive immunity. Themajor post-splenectomy immune-defects against CMV are: weakened, delayed or absent anti-CMV IgM, and compensatory marked IgG response; severely impaired B-cell and CD4, CD8 T-cells function responses; and postsplenectomy, bone marrow compensates for the absence of spleen’s immune responses against CMV, mimicking a monoclonal T-cell lymphoproliferative process. Conclusion:The puzzled diagnosis of the CMV syndrome post-splenectomy is of the most challenging andmisleading, resulting in risky and costly interventions and a subsequent prolonged hospitalization (2 months). The mounting multi-disciplinary literature evidence renders us to suggest that splenectomized individuals are not only prone to encapsulated bacteria but also behave as immunocompromised to CMV. Abbreviations: BAL= bronchoalveolar lavage, BM = bone marrow, CMV= cytomegalovirus, CNS= central nervous system, GC = germinal center, IFN = interferon, IL = interleukin, LGLs = large granular lymphocytes, MCMV = murine CMV, NK = natural killer, PCR = polymerase chain reaction, SMZ = splenic marginal zone, TCR = T-cell receptor, WBC = white blood cell.
The enhanced immunopharmacology of VIB4920, a novel Tn3 fusion protein and CD40L antagonist, and assessment of its safety profile in cynomolgus monkeys

Inhibition of the T‐ and B‐cell interaction through the CD40/CD40 ligand (L) axis is a favourable approach for inflammatory disease treatment. Clinical studies of anti‐CD40L molecules in autoimmune diseases have met challenges because of thromboembolic events and adverse haemostasis. VIB4920 (formerly MEDI4920) is a novel CD40L antagonist and Tn3 fusion protein designed to prevent adverse haemostasis and immunopharmacology. We evaluated the pharmacokinetics, activity and toxicity of VIB4920 in monkeys.