Miracle-dz/UniFAR-FTUs huggingface dataset:
Mobile website characteristics of leading tobacco product brands: cigarettes, smokeless tobacco, e-cigarettes, hookah and cigars

Significance Most US adults use smartphones for internet access. Understanding what they see when they view smartphone-optimised (mobile) tobacco websites is important, as it can inform tobacco education and cessation strategies. This study describes mobile tobacco websites for leading brands of cigarettes, cigars, smokeless tobacco (smokeless), e-cigarettes and hookah. Methods We identified 130 leading tobacco brands based on sales, advertising spending and self-report data. Of these, 62 brands had mobile websites. We conducted an inductive content analysis (ie, where we derived the coding scheme from what we observed) of website characteristics by dual-coding: age requirements, warning display, brand engagement methods (eg, social features) and sales strategies (eg, coupons). Results All cigarette and most smokeless websites required age-verified accounts for entry, while 76% of e-cigarette websites required accounts only for making purchases. All cigarette and smokeless websites showed warnings, but a minority of e-cigarette and cigar websites did, and no hookah websites did. Many websites required users to scroll up to view warnings. Most e-cigarette websites, most hookah websites, and half of cigar websites linked to multiple social media platforms; however, most cigarette and smokeless websites facilitated socialisation internally. All cigarette, most smokeless and no hookah websites offered coupons. Many cigarette and smokeless coupons were time-sensitive and location-based. Conclusions We highlight issues in how tobacco brand websites address youth access, display warnings, engage consumers and facilitate purchase. Results can help public health educators and practitioners better understand tobacco marketing as a context for designing tobacco interventions.
Sidestep-induced neuromuscular miswiring causes severe locomotion defects in Drosophila larvae

ABSTRACT Mutations in motor axon guidance molecules cause aberrant projection patterns of motor nerves. As most studies in Drosophila have analysed these molecules in fixed embryos, the consequences for larval locomotion are entirely unexplored. Here, we took advantage of sidestep (side)-mutant larvae that display severe locomotion defects because of irreparable innervation errors. Mutations in side affected all motor nerve branches and all body wall regions. Innervation defects were non-stereotypical, showing unique innervation patterns in each hemisegment. Premature activation of Side in muscle precursors abrogated dorsal migration of motor nerves, resulting in larvae with a complete loss of neuromuscular junctions on dorsal-most muscles. High-speed videography showed that these larvae failed to maintain substrate contact and inappropriately raised both head and tail segments above the substrate, resulting in unique ‘arching’ and ‘lifting’ phenotypes. These results show that guidance errors in side mutants are maintained throughout larval life and are asymmetrical with respect to the bilateral body axis. Together with similar findings in mice, this study also suggests that miswiring could be an underlying cause of inherited movement disorders. Highlighted Article: Misexpression of the Drosophila axon guidance molecule Sidestep results in a permanent loss of neuromuscular junctions and severe innervation and locomotion defects in embryos and larvae.
“Please listen to me”: A cross-sectional study of experiences of seniors and their caregivers making housing decisions

Background Little is known about the decision-making experiences of seniors and informal caregivers facing decisions about seniors’ housing decisions when objective decision making measures are used. Objectives To report on seniors’ and caregivers’ experiences of housing decisions. Design A cross-sectional study with a quantitative approach supplemented by qualitative data. Setting Sixteen health jurisdictions providing home care services, Quebec province, Canada. Participants Two separate samples of seniors aged ≥ 65 years and informal caregivers of cognitively impaired seniors who had made a decision about housing. Measurements Information on preferred choice and actual choice about housing, role assumed in the decision, decisional conflict and decision regret was obtained through closed-ended questionnaires. Research assistants paraphrased participants’ narratives about their decision-making experiences and made other observations in standardized logbooks. Results Thirty-one seniors (median age: 85.5 years) and 48 caregivers (median age: 65.1 years) were recruited. Both seniors and caregivers preferred that the senior stay at home (64.5% and 71.7% respectively). Staying home was the actual choice for only 32.2% of participating seniors and 36.2% of the seniors cared for by the participating caregivers. Overall, 93% seniors and 71% caregivers reported taking an active or collaborative role in the decision-making process. The median decisional conflict score was 23/100 for seniors and 30/100 for caregivers. The median decision regret score was the same for both (10/100). Qualitative analysis revealed that the housing decision was influenced by factors such as seniors’ health and safety concerns and caregivers’ burden of care. Some caregivers felt sad and guilty when the decision did not match the senior’s preference. Conclusion The actual housing decision made for seniors frequently did not match their preferred housing option. Advanced care planning regarding housing and better decision support are needed for these difficult decisions.
Towards the first adversarially robust neural network model on MNIST

Despite much effort, deep neural networks remain highly susceptible to tiny input perturbations and even for MNIST, one of the most common toy datasets in computer vision, no neural network model exists for which adversarial perturbations are large and make semantic sense to humans. We show that even the widely recognized and by far most successful defense by Madry et al. (1) overfits on the L-infinity metric (it's highly susceptible to L2 and L0 perturbations), (2) classifies unrecognizable images with high certainty, (3) performs not much better than simple input binarization and (4) features adversarial perturbations that make little sense to humans. These results suggest that MNIST is far from being solved in terms of adversarial robustness. We present a novel robust classification model that performs analysis by synthesis using learned class-conditional data distributions. We derive bounds on the robustness and go to great length to empirically evaluate our model using maximally effective adversarial attacks by (a) applying decision-based, score-based, gradient-based and transfer-based attacks for several different Lp norms, (b) by designing a new attack that exploits the structure of our defended model and (c) by devising a novel decision-based attack that seeks to minimize the number of perturbed pixels (L0). The results suggest that our approach yields state-of-the-art robustness on MNIST against L0, L2 and L-infinity perturbations and we demonstrate that most adversarial examples are strongly perturbed towards the perceptual boundary between the original and the adversarial class.
Comparison of Linear and Reverse Linear Periodized Programs With Equated Volume and Intensity for Endurance Running Performance.

Bradbury, DG, Landers, GJ, Benjanuvatra, N, and Goods, PS. Comparison of linear and reverse linear periodized programs with equated volume and intensity for endurance running performance. J Strength Cond Res XX(X): 000-000, 2018-This investigation examined the effectiveness of 2 periodization methods on endurance running performance. Thirty recreational runners (25.2 ± 7.4 years; 175.4 ± 8.1 cm; 69.0 ± 9.8 kg) were assigned to 3 groups based on preintervention test results: linear periodization group (LPG, n = 10), reverse linear periodization group (RPG, n = 10), and control group (CG, n = 10). The LPG and RPG completed 3 training sessions (2 supervised and 1 unsupervised) per week in two 6-week blocks. The LPG went through a high-volume training program while the RPG performed higher intensity, lower volume training in the initial block. Training volume and intensity was reversed in the second 6-week training block. All subjects completed pre-training (week 0), midpoint (week 7), and post-training (week 14) testing, which included anthropometric measurements (body mass and sum of 8 skinfolds), treadmill tests for running economy (RE) and V[Combining Dot Above]O2max, and a 5,000-m time trial (TT) on a 400-m grass track. Greater improvements in the 5,000-m TT were observed in the LPG (76.8 ± 55.8 seconds, p = 0.009, d = 1.27) and the RPG (112.8 ± 83.4 seconds, p = 0.002, d = 1.51) than the CG (3.6 ± 59 seconds). No significant differences were found between the LPG and RPG (p = 0.321, d = 0.51). No group differences were found for V[Combining Dot Above]O2peak (p = 0.955) or RE at 9 km·h (p = 0.329) or 11 km·h (p = 0.558), respectively. However, significant improvements were seen in these variables after training: V[Combining Dot Above]O2peak (p = 0.010), RE 9 km·h (p < 0.001), and RE 11 km·h (p = 0.004). These results do not support linear periodization or reverse linear periodization as a superior method; however, periodized training elicited greater improvements in endurance performance than nonperiodized training, highlighting the importance of planned training structure.
Childhood cancer incidence and survival in Thailand: A comprehensive population‐based registry analysis, 1990–2011

Southeast Asia is undergoing a transition from infectious to chronic diseases, including a dramatic increase in adult cancers. Childhood cancer research in Thailand has focused predominantly on leukemias and lymphomas or only examined children for a short period of time. This comprehensive multisite study examined childhood cancer incidence and survival rates in Thailand across all International Classification of Childhood Cancer (ICCC) groups over a 20‐year period.
Evaluation of the blend of organic acids and medium‐chain fatty acids in matrix coating as antibiotic growth promoter alternative on growth performance, nutrient digestibility, blood profiles, excreta microflora, and carcass quality in broilers

ABSTRACT This study was conducted to evaluate the effects of the blend of organic acids (OAs) and medium‐chain fatty acids (MCFAs) in broiler chickens. A total of 816 1‐d‐old male Ross 308 broiler chickens (35 ± 0.44 g) were randomly allocated into 1 of the following 6 dietary treatments (17 broilers per pen with 8 pens per treatment): dietary treatments consisted of corn‐soybean meal‐based basal diet and the basal diet supplemented with 0.02, 0.03, 0.04, 0.05, and 0.06% blend of OAs and MCFAs. The study lasted 5 wk during which growth performance was determined. In the current study, the inclusion of 0.02, 0.03, 0.04, 0.05, and 0.06% blend of OAs and MCFAs in the basal diet linearly increased (P < 0.05) body weight gain and improved feed conversion ratio (P < 0.0001) on day 7 to 14, day 14 to 35, as well as overall. Increasing inclusion of the blend of OAs and MCFAs levels in the diets also linearly increased (P = 0.001) the digestibility of dry matter on day 35. Broilers fed with different levels of the blend of OAs and MCFAs showed a linear increment (P = 0.042) in Lactobacillus concentration and decrease (P = 0.002) in Escherichia coli concentration. With regard to relative organ weight, a trend of linear reduction (P = 0.052) in bursa of Fabricius weight of broilers fed the blend of OAs and MCFAs was observed. There was a significant linear improvement (P = 0.011) in the IgG concentration associated with the inclusion of the blend of OAs and MCFAs levels in the diets. In conclusion, the blend of OAs and MCFAs supplementation positively influenced growth performance, nutrient digestibility, and excreta microflora in broiler chickens.
Retrieval-Based Neural Code Generation

In models to generate program source code from natural language, representing this code in a tree structure has been a common approach. However, existing methods often fail to generate complex code correctly due to a lack of ability to memorize large and complex structures. We introduce RECODE, a method based on subtree retrieval that makes it possible to explicitly reference existing code examples within a neural code generation model. First, we retrieve sentences that are similar to input sentences using a dynamic-programming-based sentence similarity scoring method. Next, we extract n-grams of action sequences that build the associated abstract syntax tree. Finally, we increase the probability of actions that cause the retrieved n-gram action subtree to be in the predicted code. We show that our approach improves the performance on two code generation tasks by up to +2.6 BLEU.
Use of a patient-centred educational exchange (PCEE) to improve patient’s self-management of medicines after a stroke: a randomised controlled trial study protocol

Introduction National and international guidelines make recommendations for secondary prevention of stroke including the use of medications. A strategy which engages patients in a conversation to personalise evidence-based educational material (patient-centred educational exchange; PCEE) may empower patients to better manage their medications. Methods and analysis This protocol outlines a non-blinded randomised controlled trial. Consenting patients admitted with a diagnosis of stroke or transient ischaemic attack will be randomised 1:1 to receive either a PCEE composed of two sessions, one at the bedside before discharge and one by telephone at least 10 days after discharge from hospital in addition to usual care (intervention) or usual care alone (control). The primary aim of this study is to determine whether a PCEE improves adherence to antithrombotic, antihypertensive and lipid-lowering medications prescribed for secondary prevention of stroke over the 3 months after discharge, measured using prescription-refill data. Secondary aims include investigation of the impact of the PCEE on adherence over 12 months using prescription-refill data, self-reported medication taking behaviour, self-reported clinical outcomes (blood pressure, cholesterol, adverse medication events and readmission), quality of life, the cost utility of the intervention and changes in beliefs towards medicines and illness. Ethics and dissemination Communication of the trial results will provide evidence to aid clinicians in conversations with patients about medication taking behaviour related to stroke prevention. The targeted audiences will be health practitioners and consumers interested in medication taking behaviour in chronic diseases and in particular those interested in secondary prevention of stroke. The trial has ethics approval from Metro South Human Research Ethics Committee (HREC/15/QPAH/531) and The University of Queensland Institutional Human Research Ethics (2015001612). Trial registration number ACTRN12615000888561; Pre-results.
Three-dimensional genome structures of single diploid human cells

The structure of the genome Beyond the sequence of the genome, its three-dimensional structure is important in regulating gene expression. To understand cell-to-cell variation, the structure needs to be understood at a single-cell level. Chromatin conformation capture methods have allowed characterization of genome structure in haploid cells. Now, Tan et al. report a method called Dip-C that allows them to reconstruct the genome structures of single diploid human cells. Their examination of different cell types highlights the tissue dependence of three-dimensional genome structures. Science, this issue p. 924 A single-cell chromatin conformation capture method employs transposon-based whole-genome amplification to detect chromatin contacts. Three-dimensional genome structures play a key role in gene regulation and cell functions. Characterization of genome structures necessitates single-cell measurements. This has been achieved for haploid cells but has remained a challenge for diploid cells. We developed a single-cell chromatin conformation capture method, termed Dip-C, that combines a transposon-based whole-genome amplification method to detect many chromatin contacts, called META (multiplex end-tagging amplification), and an algorithm to impute the two chromosome haplotypes linked by each contact. We reconstructed the genome structures of single diploid human cells from a lymphoblastoid cell line and from primary blood cells with high spatial resolution, locating specific single-nucleotide and copy number variations in the nucleus. The two alleles of imprinted loci and the two X chromosomes were structurally different. Cells of different types displayed statistically distinct genome structures. Such structural cell typing is crucial for understanding cell functions.
Implant‐associated gene expression in the jaw bone of smokers and nonsmokers: A human study using quantitative qPCR

OBJECTIVES This study aimed to compare the molecular events in implant-adherent cells and in peri-implant bone during the osseointegration of machined and oxidized titanium implants in smokers and nonsmokers. MATERIALS AND METHODS Twenty-four smokers and 24 nonsmokers each received machined and anodically oxidized mini-implants. The mini-implants and the surrounding bone were retrieved after 1, 7, and 28 days, for gene expression analysis of selected factors using quantitative polymerase chain reaction (qPCR). RESULTS Differences between machined and oxidized implants were more evident in the implant-adherent cells than the peri-implant bone. The machined implants revealed higher expression of proinflammatory cytokines, interleukin-8 (IL-8) (in nonsmokers), and tumor necrosis factor-alpha (in nonsmokers and smokers), compared with the oxidized implants. Conversely, the expression of bone formation genes, alkaline phosphatase and osteocalcin, was generally higher at the oxidized implants. In smokers, the temporal pattern revealed the delayed and initial inhibition of osteoblastic and osteoclastic gene expression, respectively, mainly at the machined implants. In contrast, oxidized implants revealed higher expression of bone remodeling, cathepsin K (CatK) and calcitonin receptor, and coupling, receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin, genes after 7 day in smokers. CONCLUSIONS The implant-adherent cells are more sensitive to surface properties and smoking conditions than the cells in the peri-implant bone. Smoking imposes inhibitory effects on the initial molecular events of osseointegration in the human bone-implant interface. The surface properties of oxidized implants appear to have a beneficial effect on osseointegration by mitigating the smoking-induced negative effects.
Bacteriophages Contribute to Shaping Clostridioides (Clostridium) difficile Species

Bacteriophages (phages) are bacterial viruses that parasitize bacteria. They are highly prevalent in nature, with an estimated 1031 viral particles in the whole biosphere, and they outnumber bacteria by at least 10-fold. Hence, phages represent important drivers of bacterial evolution, although our knowledge of the role played by phages in the mammalian gut is still embryonic. Several pathogens owe their virulence to the integrated phages (prophages) they harbor, which encode diverse virulence factors such as toxins. Clostridioides (Clostridium) difficile is an important opportunistic pathogen and several phages infecting this species have been described over the last decade. However, their exact contribution to the biology and virulence of this pathogen remains elusive. Current data have shown that C. difficile phages can alter virulence-associated phenotypes, in particular toxin production, by interfering with bacterial regulatory circuits through crosstalk with phage proteins for example. One phage has also been found to encode a complete binary toxin locus. Multiple regulatory genes have also been identified in phage genomes, suggesting that their impact on the host can be complex and often subtle. In this minireview, the current state of knowledge, major findings, and pending questions regarding C. difficile phages will be presented. In addition, with the apparent role played by phages in the success of fecal microbiota transplantation and the perspective of phage therapy for treatment of recurrent C. difficile infection, it has become even more crucial to understand what C. difficile phages do in the gut, how they impact their host, and how they influence the epidemiology and evolution of this clinically important pathogen.
A six‐year observational study of 31 children with early‐onset scoliosis treated using magnetically controlled growing rods with a minimum follow‐up of two years

Aims Magnetically controlled growing rod (MCGR) systems use non‐invasive spinal lengthening for the surgical treatment of early‐onset scoliosis (EOS). The primary aim of this study was to evaluate the performance of these devices in the prevention of progression of the deformity. A secondary aim was to record the rate of complications. Patients and Methods An observational study of 31 consecutive children with EOS, of whom 15 were male, who were treated between December 2011 and October 2017 was undertaken. Their mean age was 7.7 years (2 to 14). The mean follow‐up was 47 months (24 to 69). Distractions were completed using the tailgating technique. The primary outcome measure was correction of the radiographic deformity. Secondary outcomes were growth, functional outcomes and complication rates. Results The mean Cobb angle was 54° (14° to 91°) preoperatively and 37° (11° to 69°) at the latest follow‐up (p < 0.001). The mean thoracic kyphosis (TK) was 45° (10° to 89°) preoperatively and 42° (9° to 84°) at the latest follow‐up. The mean T1‐S1 height increased from 287 mm (209 to 378) to 338 mm (240 to 427) (p < 0.001) and the mean sagittal balance reduced from 68 mm (‐76 to 1470) preoperatively to 18 mm (‐32 to 166) at the latest follow‐up. The mean coronal balance was 3 mm (‐336 to 64) preoperatively and 8 mm (‐144 to 64) at the latest follow‐up. The mean increase in weight and sitting and standing height at the latest followup was 45%, 10% and 15%, respectively. The mean Activity Scale for Kids (ASKp) scores increased in all domains, with only personal care and standing skills being significant at the latest follow‐up (p = 0.02, p = 0.03). The improvements in Cobb angle, TK and T1‐S1 heights were not related to gender, the aetiology of the EOS, or whether the procedure was primary or conversion from a conventional growing rod system. A total of 21 children developed 23 complications at a rate of 0.23 per patient per year. Seven developed MCGR‐specific complications. Complications developed at a mean of 38 months (3 to 67) after the initial surgery and required 22 further procedures. Children who developed a complication were more likely to be younger, have syndromic EOS, and have a single‐rod construct (6.9 versus 9.3 years, p = 0.034). Conclusion The progression of EOS can be controlled using MCGRs allowing growth and improved function. Younger and syndromic children are more likely to develop complications following surgery.