Miracle-dz/UniFAR-FTUs huggingface dataset:
Preparative Regimen for Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients with Hematologic Malignancies: A Therapeutic Advances in Childhood Leukemia

Clofarabine is a purine nucleoside analog with immunosuppressive and anti-leukemic activity and its inclusion in reduced intensity regimens could potentially improve outcomes. We performed a prospective Phase I study of clofarabine combined with 2 Gy total body irradiation (TBI) as a non-myeloablative (NMA) preparative regimen for allogeneic stem cell transplantation in pediatric patients, who were considered at high risk of mortality from standard myeloablative regimens. The main goal of the study was to delineate the maximum feasible dose (MFD) of clofarabine in combination with 2 Gy TBI. Eighteen patients, 1-21 years of age and in complete remission were enrolled in the two stratamatched related donor (RD) and unrelated donor (UD) and evaluated for day100 dose limiting events (DLE-non-engraftment, non-relapse mortality (NRM), and severe renal insufficiency) after receiving clofarabine at the starting dose level of 40 mg/m 2 . All 6 patients (3 in each stratum) engrafted with no day100 DLE seen in the first cohort. The dose was increased to 52 mg/m 2 in the next and an expanded cohort (total 12 patients) and no DLE was observed at day100 and at 1-year study endpoint. The regimen was well tolerated with transient transaminitis, gastrointestinal and skin reactions as the common reversible toxicities observed with clofarabine. 52 mg/m 2 of clofarabine was deemed the MFD. Disease relapse led to mortality in 6 (33%) patients during follow-up with 1-year event free survival and overall survival of 60% (95% CI, 34-79) and 71% (95% CI, 44-87), respectively.
INSTANT MESSAGING: A THREAT FOR POOR SPELLERS WHOSE SPELLING IS IN THE PROCESS OF BEING CONSOLIDATED

It is hard to make a clear status about the link between instant messaging and spelling. We dug into 2 areas that found no clear answer in the literature. In a first study, we compared the amount of modified words produced in instant messaging by French and American adolescents (both orthographies are opaque but cultural and economic aspects differ). Results showed the first produced more modified words than the latter. These aspects would matter to explain the amount of modified words. In a second study, we compared the amount of misspellings on paper and modified pseudo-words in instant messaging. There were 3 groups (made of good and poor French spellers) for 3 exposure phases (12 weeks): not exposed to instant messaging; exposed during 6 weeks; exposed during 12 weeks. Results showed poor spellers produced more misspellings than good spellers – only for the second group. There would be a risk for poor spellers whose spelling is being consolidated.
Effects of corona discharge treatment on the mechanical properties of biocomposites from polylactic acid and Algerian date palm fibres

In this paper, biocomposites materials based on date palm fibres (untreated or treated with corona discharge) as reinforcing elements and polylactic acid matrices were prepared and characterized. The objective of this study was to evaluate the mechanical properties of these biocomposites by modification of date palm fiber by using corona discharge treatment which results in a surface oxidation. The morphology of processed biocomposites was studied by scanning electron microscopy. It was found that treated fibers of the reinforced composite showed superior mechanical properties as compared with untreated fiber reinforced composites due to the enhanced adhesion between the treated date palm fiber and the polylactic acid matrix. Changes in the surface chemistry were investigated with Fourier Transform infrared spectroscopy. Moreover, morphological studies by scanning electron microscopy demonstrated that better adhesion between the treated fiber and the matrix was achieved. Such studies are of great interest in the development of environmentally friendly composites from biodegradable polymers.
Effect of forage/concentrate ratio and soybean oil supplementation on milk yield, and composition from Sarda ewes

Sixteen lactating Sarda ewes were fed four diets differing in the forage/concentrate ratio (two diets 75/25, two diets 60/40, on a DM basis) and in soybean oil supplementation (two diets with 100 g·d −1 oil, two diets with no oil), in a 4 × 4 Latin square design. The inclusion of soybean oil in the diet resulted in a significant increase of both daily milk yield and fat corrected milk (P ≤ 0.01), while diets with higher concentrate content resulted in lower levels of milk production (P ≤ 0.05). Milk fat content did not differ among treatments, while milk fat yield was increased when ewes consumed oil added diets (P < 0.01). Milk protein content was lower when oil was added to the diet (P ≤ 0.01), which was attributed to a dilution effect, while milk protein secretion did not differ among treatments. Dietary soybean oil modified the milk fatty acid composition towards a lower level of medium chain and saturated fatty acid and a higher level of PUFA and CLA, confirming how an adequate dietary strategy can broadly modify sheep milk quality towards a more desirable composition for human health. In particular, soybean oil in the diet resulted in a significant increase of both rumenic acid (cis-9, trans-11 CLA) and vaccenic acid (trans-11 C18:1) in milk fat. Interactions among forage and oil resulted in a significant increase in rumenic acid and vaccenic acid with the HF/ Od iet andtrans-10 C18:1 and trans-10, cis-12 CLA with the LF/O diet, probably due to a shift in rumen biohydrogenation of linoleic acid. CLA / trans fatty acid / sheep milk / soybean oil
Pragmatics, point of view and theory of mind

The (tentative) conclusion of this paper is that pragmatics needs both the notions of point of view and of theory of mind. Though linguistic communication may often enough proceed at a fairly low level of sophistication, relying on the pragmatic module and operating on the basis of naive optimism, it at least occasionally involves fairly sophisticated processes which involve perspective taking and operate at more sophisticated or even very sophisticated level of theory of mind. This may be the case not only in face to face communication, but in delayed communication, as for instance in reading a book. Such sophisticated mind-reading involved in linguistic communication may be more commonplace than is generally believed and though we may be content to toddle along most of the time, we may still need some mental sophistication from time to time. Indeed, a good example is given by Heavey et al. (2000) who used TV commercials to test the performance of adult Asperger Syndrome patients, autists and control participants in theory of mind. The commercials, taken from regular TV, were certainly not anything out of the ordinary, but they still were difficult if not impossible to understand for Asperger Syndrome and autistic patients. Pragmatics cannot ignore theory of mind if it aims at understanding communicative processes. It can not ignore point of view and perspective either.
EFFECTS OF BANKING STRUCTURE ON THE ALLOCATION OF CREDIT TO NONMETROPOLITAN COMMUNITIES

Recent and proposed legislative changes encourage increases in multioffice banking activity. In this manuscript, the allocation of credit to nonmetropolitan communities in a branch banking state (Arizona) is compared to that in a unit banking-holding company state (Colorado). Rapidly growing nonmetropolitan areas have experienced increased lending activity under statewide branching relative to unit banking. Rural communities, which experienced slow or negative growth, had lower loan-to-deposit rations under branch banking than might have existed under unit banking. Therefore, conversion to branch banking may result in a reallocation of loanable funds within nonmetropolitan areas.
Motivational Interviewing With Dually Diagnosed Adolescents in Juvenile Justice Settings

Recent empirical investigations have gathered data regarding the rates of psychiatric comorbidity within juvenile justice populations. Data from these studies detail the prevalence of risk-taking behavior, substance abuse and dependence, posttraumatic stress disorder, and sexual risk taking. In addition to reviewing these findings, this paper explores the use of motivational interviewing (MI) with adult offenders and adolescent substance users. The efficacy of MI in these areas indicates the potential fit of MI with juvenile justice populations. Although the application of MI with this population is theoretically indicated, research is needed to garner empirical support for this application of MI. [Brief Treatment and Crisis Intervention 6:218–233 (2006)]
Dominant achievement goals and academic outcomes across tracks in high school

Abstract The self-reported grades Dutch, English and Math of 13,970 students in the third grade of Dutch secondary education (US grade 9) were investigated with regard to educational track-level and dominant achievement goal (DAG). The performance approach goal group scored significantly higher on all three subjects than the performance avoidance group, the mastery approach group, the mastery avoidance group and the group without a DAG. In addition, the differences between the performance approach group and the other groups with regard to the three school subjects were of the same size, suggesting that the DAG is associated with the same processes across various school subjects. The magnitude of the differences between the other DAG groups, however, decreased with decreasing track level, suggesting that the DAGs’ adaptive value varies systematically with ability level.
Export Participation and Technical Efficiency in East African Manufacturing Firms

The study analyzed two explanations for the positive association between export-participation status and efficiency, i.e., self-selection of the relatively more efficient firms into exporting, and learning-by-exporting. Measures of firm-level efficiency using Data Envelopment Analysis (DEA) were estimated to investigate the relationship between export participation and firm-level efficiency. As a result of the binary nature of the export participation, probit technique was used to estimate the export participation equation. No evidence of self-selection by the relatively more efficient firms into-exporting was found, as lagged efficiency does not affect the probability of exporting in East African manufacturing firms. One explanation is that factors other than technical efficiency may be playing a more prominent role as determinants of the export decision in East African manufacturing firms.
License to sin: Self-licensing as a mechanism underlying hedonic consumption

Hedonic overconsumption is often considered to be caused by impulsive factors. The current paper investigates whether self-licensing, relying on reasons to justify subsequent gratification, can also be included as a significant contributor to hedonic consumption. Two studies were conducted to investigate whether self-licensing can account for an increase in hedonic consumption while ruling out impulsive factors such as resource depletion, negative affect, and visceral state as alternative explanations. A pilot study indicated that perceiving oneself as having invested greater effort and thus having a self-licensing cue did not lead to a decline in self-control capacity compared with not having a self-licensing cue. The main study employed the same procedure and established that having a licensing cue did lead to increased snack intake while controlling for impulsive factors. Together, these studies support the notion that self-licensing is a separate mechanism leading to hedonic gratification independent of impulsive factors. Copyright © 2011 John Wiley & Sons, Ltd.
Water requirements of avocado in Israel. II.* Influence on yield, fruit growth and oil content

The effect of four different irrigation intervals, 7, 14, 21 and 28 days, on the avocado tree was tested during the years 1968–1974 in the northern coastal plain of Israel. The respective average annual water applications were 8890, 7450, 6680 and 5940 m3/ha. The cultivars Ettinger, Fuerte and Hass were tested in five replications in randomized blocks. After 6 years no significant reduction in yield was observed with Ettinger or Fuerte trees irrigated once in 21 or 28 days. With the Hass cultivar the 28-day interval gave lower yields than with the three other intervals tested. Shortening of irrigation intervals increased the growth rate and size of individual fruits, which may be of economic importance for cv. Hass, where overproduction leads to small fruits unsuitable for export. Shortening of irrigation intervals tended to increase the oil percentage of the fruit, which may advance the harvest date. In view of the equal yields obtained and the predominance of cv. Hass in avocado plantations, it was concluded that the 21-day interval was the optimum irrigation frequency under the experimental conditions. __________________ *Part I, Aust. J. Agric. Res., 28: 859 (1977).
Value Investing with Firm Size Restrictions: Evidence for the German Stock Market

Recent findings by Fama and French (2012) suggest a decreasing pattern of value premia alongside an increase in firm size. Large trading volumes of value investors often restrict their investment possibilities to large, liquid stocks and raise a serious issue if large cap value premia are diminishing. Thereon, we test for the existence of value premia with respect to seven fundamental metrics subject to a large cap sample restriction. We provide evidence for the German stock market and observe statistically significant Carhart alphas across all tested value metrics between 1988 until 2012, even after accounting for the total market HML risk factor. Finally, we look at pre- and post-rebalancing months and observe significantly negative value premia before rebalancing and an opposite pattern for past rebalancing returns. Furthermore, we identify calendar effects for value premia when considering a 12-month holding period.
Threats in dreams, emotions and the severity of threatening experiences in waking

One of the prepositions of the Threat Simulation Theory (TST) suggests that the experience of threatening events in waking life would be associated with the experience of oneiric threats, which is consistent with the Continuity hypothesis. Following on that proposition, dream diaries and daily event diaries of the day preceding the dreams were collected from 40 female and 40 male undergraduate students who rated the intensity of anger and fear experienced during the day and in the course of their dreams. The severity and frequency of threatening events in both conditions was evaluated by two independent judges on a scale developed on the basis of the severity component of Revonsuo’s Dream Threat Scale. There were significant correlations between the severity of threatening day events and the severity of threats in dream diaries (r(80) = . 22, p = . 048), and between the frequency of daytime threats and dream threats (r(80) = . 41, p = . 001). There were also significant correlations between pre-sleep anger and anger in dreams (r(80) = . 39, p = . 01, and between fear before bedtime and the severity of dream threats (r(80) = . 33, p =. 003). In addition, different gender-specific relationships emerged, coincident with the consistently observed predominance of negative emotions in women’s dreams. These findings provide some support for both the Threat Stimulation Theory and the Continuity hypothesis. Further exploration over a longer time frame is required to better understand the relationship between these emotions experienced in waking and dreams.
Principles for urban stormwater management to protect stream ecosystems

Urban stormwater runoff is a critical source of degradation to stream ecosystems globally. Despite broad appreciation by stream ecologists of negative effects of stormwater runoff, stormwater management objectives still typically center on flood and pollution mitigation without an explicit focus on altered hydrology. Resulting management approaches are unlikely to protect the ecological structure and function of streams adequately. We present critical elements of stormwater management necessary for protecting stream ecosystems through 5 principles intended to be broadly applicable to all urban landscapes that drain to a receiving stream: 1) the ecosystems to be protected and a target ecological state should be explicitly identified; 2) the postdevelopment balance of evapotranspiration, stream flow, and infiltration should mimic the predevelopment balance, which typically requires keeping significant runoff volume from reaching the stream; 3) stormwater control measures (SCMs) should deliver flow regimes that mimic the predevelopment regime in quality and quantity; 4) SCMs should have capacity to store rain events for all storms that would not have produced widespread surface runoff in a predevelopment state, thereby avoiding increased frequency of disturbance to biota; and 5) SCMs should be applied to all impervious surfaces in the catchment of the target stream. These principles present a range of technical and social challenges. Existing infrastructural, institutional, or governance contexts often prevent application of the principles to the degree necessary to achieve effective protection or restoration, but significant potential exists for multiple co-benefits from SCM technologies (e.g., water supply and climate-change adaptation) that may remove barriers to implementation. Our set of ideal principles for stream protection is intended as a guide for innovators who seek to develop new approaches to stormwater management rather than accept seemingly insurmountable historical constraints, which guarantee future, ongoing degradation.
Organizational Culture Types and Their Effects on Organizational Performance in Turkish Hospitals

Nowadays a cultural transformation is seen in healthcare industry in Turkey because of important structural changes due to implemented exchange programs and liberalization policies on national basis. In this condition hospitals, as a business, make an effort to gain above average returns while serving the health services. According to the literature, one of the substantial intangible forces that affect performance is organizational culture. Thus, this study aims to identify the dominant organizational culture types of private and public hospitals while make a comparison between their effects on business performance. To examine the research questions a questionnaire survey performed, and data collected from 512 employees of 99 hospitals which are located in large cities of Turkey are analysed by using SPSS 15 program.
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cIAP2 is a key regulator of programmed cell death and the NF-jB pathway. Here, we investigated the post-transcriptional regulation of cIAP2 expression by tristetraprolin (TTP). Our results showed that overexpression of TTP reduced the stability of cIAP2 mRNA and the expression level of cIAP2. In addition, TTP destabilized a luciferase mRNA containing cIAP2 mRNA 30UTR. cIAP2 mRNA 30UTR contains four AU-rich elements (AREs) and the 2nd ARE was responsible for the TTP-mediated destabilization of the cIAP2 mRNA. RNA EMSA revealed that TTP directly bound to 42 nucleotides from the 30UTR of cIAP2 mRNA containing the 2nd ARE. However, the 42 nucleotides did not promote TTP-dependent destabilization of mRNA and did not recruit the decapping enzyme Dcp2 and the 50–30 exonuclease Xrn1. When we used a 52 nucleotide sequence containing an additional 5 nucleotides from cIAP2 mRNA 30UTR at both ends, this long nucleotide sequences recruited Dcp2 and Xrn1 and promoted TTP-dependent destabilization of mRNA. Collectively, our results suggest that TTP can bind to the 2nd ARE of cIAP2 mRNA 30UTR and destabilize cIAP2 mRNA by forming complexes with Dcp2 and Xrn1. However, while a short nucleotide sequence containing the 2nd ARE of cIAP2 mRNA can recruit the TTP binding, this cannot recruit Dcp2 and Xrn1 and cannot induce TTP-mediated destabilize the mRNA. Instead, additional nucleotide sequences are required to recruit Dcp2 and Xrn1 and to destabilize mRNA. 2010 Elsevier Inc. All rights reserved.
Intergroup predictors of older workers' attitudes towards work and early exit

This study investigated the role of intergroup processes in older workers' attitudes towards work and early exit from the workplace. Specifically, the relationships between four intergroup variables (cognitive and affective identification with older workers as a group, permeability of retirees' group boundaries, and permeability of younger workers' group boundaries) derived from Social Identity Theory (Tajfel & Turner, 1979) and four older workers' attitudes (early exit intention, affective organizational commitment, psychological disengagement, and competition with younger workers) were examined using a sample of 152 45- to 59-year-old Belgian workers. Hierarchical regression analyses indicated that intergroup predictors accounted for a significant proportion of the variance in each of the four older workers' attitudes after some personal and organizational variables had been held constant. Most notably, cognitive identification with older workers as a group was found to be positively related to early exit intention, whereas permeability of younger workers' group boundaries had a positive relationship to affective organizational commitment, and a negative relationship to psychological disengagement and to competition with younger workers. Implications of these findings and directions for future research are discussed.
Slum Upgrading: Can the 1.5 °C Carbon Reduction Work with SDGs in these Settlements?

The need to improve slum housing is a major urban planning agenda, especially in Africa and Asia. This article addresses whether it seems feasible to do this whilst helping achieve the 1.5 °C agenda, which requires zero carbon power along with enabling the Sustainable Development Goals. Survey data from Jakarta and Addis Ababa on the metabolism and liveability of slums are used to illustrate these issues. The article shows that this is possible due to advances in community-based distributed infrastructure that enable community structures to be retained whilst improving physical conditions. The urban planning implications are investigated to enable these ‘leapfrog’ technologies and a more inclusive approach to slums that enables in situ redevelopment instead of slum clearance, and which could be assisted through climate financing.