Miracle-dz/UniFAR-FTUs huggingface dataset:
Personal thoracic CIP10-T sampler and its static version CATHIA-T.

A specific version of the personal aerosol sampler CIP 10 was designed, named CIP10-T, for sampling the conventional CEN thoracic fraction. A static sampler, named CATHIA, was also designed. It uses the same sampling head, but the size selected particles are collected onto a filter. The combined particle efficiency of the aspiration slot and the selector was measured in a horizontal wind tunnel at low air velocity, close to 16 cm s-1. The flow rate of both samplers was fixed at its nominal value, i.e., 71 min-1. Two different methods were used: the former was based on the Aerodynamic Particle Sizer (TSI); the latter used the measurement of particle size distribution of the collected samples by the Coulter technique. For the CIP10-T sampler, the particle collection efficiency onto the rotating cup was also measured. For both samplers bias and accuracy maps have been calculated, following the recommendations of a new CEN standard about sampler performance. The bias does not exceed 10% in absolute value for both samplers, within a large range of particle size distribution of the total aerosol. For the CIP10-T sampler, the accuracy map exhibits a large area where the accuracy is better than 10%, corresponding for example to 4 microns < or = MMAD < or = 14 microns for GSD = 2. For the same geometric standard deviation, the accuracy is still better than 20% for 15 microns < or = MMAD < or = 21 microns. For the CATHIA-T sampler, the accuracy map can be roughly divided into two parts. The accuracy remains better than 10% for MMAD < or = 12 microns, and it remains between 10 and 20% for coarser aerosols, with 13 microns < or = MMAD < or = 20 microns, provided GSD > or = 2.
Pro-brain natriuretic peptide plasma levels, left ventricular dimensions and ejection fraction in acute dyspnoea.

OBJECTIVE To determine the association of the pro-brain natriuretic peptide (NT-proBNP) plasma levels with twodimensional echocardiographic determination of left ventricular dimensions and ejection fraction (EF) in acute dyspneic patients. STUDY DESIGN An observational cross-sectional study. PLACE AND DURATION OF STUDY Tabba Heart Institute, Karachi, from January to June 2010. METHODOLOGY One hundred patients were selected by consecutive purposive non-probability sampling who had presented with acute dyspnoea. NT-proBNP levels were assessed by commercial tests (Roche Diagnostics). The clinical diagnosis of congestive heart failure (CHF), echocardiographic assessment of left ventricular dimensions and function were compared with NT-proBNP levels. Receiver operating characteristic (ROC) curve was estimated for NT-proBNP and compared. The chi-square test was applied for categorical and student's t-test for numerical data at 0.05 levels of significance were used to compare patients with and without heart failure. Further comparative analysis between groups on the basis of ejection fraction was done by one way ANOVA test. RESULTS Seventy-nine patients (79%) had CHF as a cause of their dyspnoea. Patients with CHF were older (61.9 ± 14 years vs. 58.6 ± 14 years, p=0.368), had a lower EF (36.9% vs. 61%, p < 0.0001), had a higher LV dimensions, left ventricular end diastolic dimension - LVEDD (49.94 ± 5.6 vs. 42 ± 7.9 mm, p < 0.0001), left ventricular end systolic dimension - LVESD (37.31 ± 6 vs. 29.21 ± 10.9 mm, p < 0.0001) and a higher NT-proBNP (10918 ± 1228 vs. 461 ± 100 pg/mL, p < 0.0001) than patients without CHF. NT-proBNP values increased with the severity of ventricular impairment. Significant differences were found between patients with LVEF < 25 % and patients with moderate ventricular impairment (LVEF = 26 - 40%) and mild ventricular impairment (LVEF = 41-60%, p < 0.001). The group of patients with LV dilation, had significantly higher BNP levels than those with normal LVEDD (12416 ± 1060 pg/ml vs. 6113 ± 960, p = 0.009) and LVESD (10416 ± 1160 vs. 4513 ± 960 pg/ml, p = 0.008). Area under ROC curve for the diagnosis of CHF was significantly higher for NT-proBNP (AUC 0.99, p < 0.003). The sensitivity of NT-proBNP value of > 300 pg/mL for the diagnosis of CHF was 100% and specificity was 42%. A cut-point of 300 pg/mL NT-proBNP had 100% negative predictive value to exclude acute CHF. CONCLUSION NT-proBNP is strongly associated with two-dimensional echocardiographic determination of left ventricular dimensions and EF in identifying CHF in patients with acute dyspnoea.
Ownership Structure,Cash Flow and Capital Investment——Of the Free Cash Flow and Information Department Symmetrical Theory Test

Control and the height of the cash flow right separation offers us a very good samples of research investment cash flow sensitivity China's listed companies.Using 2004-2007 of financial and ownership data in china,we document that while the sensitivity of a firm's capital investment to its cash flow decreases as the cash-flow rights of its largest shareholders increase,this sensitivity increases as the degree of the divergence between the control rights and cash-flow rights of the firm's largest shareholders increases.We interpret the results to be consistent with the free cash-flow hypothesis,which postulates that too much free cash flow in the hands of entrenched largest shareholders is likely to lead to overinvestment,and this excessive investment is more serious in the return on assets low company.Our results not only solved debate about the sensitive of cash flow and investment due to controlling shareholders preference excess investment or lack of investment,and provide direct evidence for controlling shareholder existence "incentive effect"and "Occupy effect".
Essays on Compound Contingent Claims and Financial Guarantees

This chapter explores similarities and differences between a compound option and a two-period guarantee. A generalised compound contingent claim that captures these two claims as special cases is constructed. The underlying asset of the compound contingent claim is a generalised simple contingent claim. Similar parities as the put-call parity are derived for both these claims. Also several other claims captured by the two general claims are revealed. We also show that the "derivation of a closed form solution for the market value of a compound option under stochastic interest rates is likely to be non-trivial, if possible at all.
Jaundice with hepatic dysfunction in P. falciparum malaria.

UNLABELLED To evaluate the frequency and severity of jaundice with hepatic dysfunction in Plasmodium (P.) falciparum malaria in adult patients admitted in the hospital. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY The Infectious Diseases Unit and Medical Wards at Rashid Hospital, Dubai, United Arab Emirates, from January 2005 to December 2007. METHODOLOGY This study included 105 adult patients who fulfilled the inclusion criteria. The diagnosis of P.falciparum malaria was confirmed by examination of thin and thick film stained with Leishman's stain. Other laboratory investigations included full blood count, liver function tests, blood urea, electrolytes, serum creatinine, reticulocyte count, blood sugar, viral hepatitis serology and coagulation profile. Patient with significant clinical/biochemical hepatic dysfunction were also subjected to ultrasonic examination of abdomen. RESULTS On clinical examination, 23% patients were found to be jaundiced. Serum alanine amino transferase (ALT) level was above the reference range in 67.6%, but in only 11.4%, ALT was more than 3 times of normal level. Serum bilirubin was found to be higher than normal level in 81%, however, only in 23% of the patients, Serum bilirubin was >3mg/dl. Predominantly conjugated hyperbilirubinemia was observed in patients with high ALT. There was no significant change in serum albumin and prothrombin time. In comparison to normal bilirubin level, the patient with bilirubin >3mg/dl had high frequency of raised ALT 87.5% vs. 45% (p<.0001), thrombocytopenia 91.6% vs. 65% (p<.01), anemia 70.8% vs. 25% (p<.05) and renal impairment 50% vs. 20% (p>.05). Overall, 5 (4.7%) patients died and mortality rate was high among the patients with bilirubin level>3mg/dl than with normal bilirubin level 4 (16.6%) vs 1 (5%). CONCLUSION Hepatic dysfunction in acute P.falciparum malaria ranged from mild elevation of liver enzymes to acute hepatitis (ALT>10 times of normal level). It indicates severe illness with high frequency of complication and mortality rates.
Hepatitis B reactivation during or after direct acting antiviral therapy – implication for susceptible individuals

ABSTRACT Introduction: The FDA issued a warning following 24 cases of HBV reactivation during DAA therapy for HCV, including individuals with inactive, occult and past HBV infection. Clinical presentations ranged from asymptomatic fluctuations in HBV DNA to fulminant hepatic failure, liver transplantation and death. The mechanism is unknown. Areas covered: HCV/HBV coinfection is common, particularly in regions endemic for HBV. HCV and HBV utilize host factors to support replication; both viruses evade/impair host immunity. Clinical presentations of HBV reactivation during DAAs are summarized. Other causes of HBV reactivation are revisited and recent data regarding HBV reactivation are presented. Expert opinion: HBV reactivation during DAAs for HCV occurs, with life-threatening consequences in some individuals. The risk of HBV reactivation is observed in all HBV stages. The rapid removal of HCV likely alters and liberates host-viral ± viral-viral interactions that lead to increased HBV replication. As immune reconstitution occurs with HCV removal, host recognition of HBV DNA likely ensues followed by vigorous host immune responses leading to liver injury (HBV flare). These cases highlight the importance of HBV testing prior to initiating DAA therapy, the need for close monitoring of HBV during therapy and timely administration of anti-HBV therapy to prevent serious sequelae.
Analyzing the Trait of Routinization in Older Adults

This article reports on the development and validation of a scale designed to assess a postulated psychological trait in older adults—routinization. Some older adults are thought to be motivated to maintain the daily events of their lives in relatively unchanging and orderly patterns of regularity. Those older adults may resist change, rejecting attempts to alter patterns of daily living, and experience distress at events that require change. This trait of routinization was explored with a 20-item self-report scale. Factor analysis revealed two underlying factors: 1) Having Order and Routine in daily living, and 2) Disliking Disruption. Relationship of the instrument to other standard personality instruments was assessed; it was found that the instrument was only modestly related to other scales. Validity of the scale was tested by relating it to the frequency of occurrence of desirable and undesirable small, everyday events. Also, its relationship to two factors of mental health reported by participants in a multisession experimental intervention to increase personal control and mastery was assessed. Evidence for validity of the scale in both sets of tests was found. Further exploration of the properties of the trait measure appears warranted.
Clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia.

STUDY OBJECTIVES To evaluate clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia (VAP), including the implementation of and outcomes associated with deescalation therapy. DESIGN Prospective, observational, cohort study. SETTING Twenty ICUs throughout the United States. PATIENTS A total of 398 ICU patients meeting predefined criteria for suspected VAP. INTERVENTIONS Prospective, handheld, computer-based data collection regarding routine VAP management according to local institutional practices, including clinical and microbiological characteristics, treatment patterns, and outcomes. MEASUREMENTS AND RESULTS The most frequent ICU admission diagnoses in patients with VAP were postoperative care (15.6%), neurologic conditions (13.3%), sepsis (13.1%), and cardiac complications (10.8%). The mean (+/- SD) duration of mechanical ventilation prior to VAP diagnosis was 7.3 +/- 6.9 days. Major pathogens were identified in 197 patients (49.5%) through either tracheal aspirate or BAL fluid and included primarily methicillin-resistant Staphylococcus aureus (14.8%), Pseudomonas aeruginosa (14.3%), and other Staphylococcus species (8.8%). More than 100 different antibiotic regimens were prescribed as initial VAP treatment, the majority of which included cefepime (30.4%) or a ureidopenicillin/monobactam combination (27.9%). The mean duration of therapy was 11.8 +/- 5.9 days. In the majority of cases (61.6%), therapy was neither escalated nor deescalated. Escalation of therapy occurred in 15.3% of cases, and deescalation occurred in 22.1%. The overall mortality rate was 25.1%, with a mean time to death of 16.2 days (range, 0 to 49 days). The mortality rate was significantly lower among patients in whom therapy was deescalated (17.0%), compared with those experiencing therapy escalation (42.6%) and those in whom therapy was neither escalated nor deescalated (23.7%; chi2= 13.25; p = 0.001). CONCLUSIONS Treatment patterns for VAP vary widely from institution to institution, and the overall mortality rate remains unacceptably high. The deescalation of therapy in VAP patients appears to be associated with a reduction in mortality, which is an association that warrants further clinical study.
Unreferred chronic kidney disease: a longitudinal study.

BACKGROUND Chronic kidney disease (CKD) is a major health problem. A better understanding of the epidemiological characteristics of the different stages of CKD and the associated adverse outcomes is needed to establish and implement appropriate management strategies. METHODS A serum creatinine (SCr) level of 2.03 mg/dL or greater (> or =180 micromol/L) in men and 1.53 mg/dL or greater (> or =135 micromol/L) in women was used to identify patients with moderate to severe CKD in a predominantly Caucasian area of the United Kingdom. Patients who were unknown to renal services were identified and followed up to establish survival, rate of referral, and change in glomerular filtration rate (GFR). RESULTS The prevalence of CKD defined by SCr cutoff values was 5,554 per million population (pmp). Median calculated GFR of the cohort was 28.5 mL/min/1.73 m2 (range, 4.1 to 42.8 mL/min/1.73 m2), and median age was 83 years (range, 18 to 103 years). A total of 84.8% of patients were unknown to renal services. During a mean follow-up of 31.3 months, 8.1% of patients were referred. Median survival of the unreferred population was 28.1 months. Cardiovascular disease, cancer, and infection were the most common causes of death. Male sex, low GFR, and nonreferral were associated with poor outcome. The majority of unreferred patients had stable renal function. The incidence of new unreferred CKD during the first year of follow-up was 2,435 pmp, such that the prevalence remained stable at 4,910 pmp. Significant anemia (hemoglobin < 11 g/dL [<110 g/L]) was seen in 27.5% of the unreferred cohort. CONCLUSION Referral of all patients with CKD is unrealistic and inappropriate. Management strategies aimed at improving adverse outcomes need to take account of this and be developed and implemented through collaboration between primary care and secondary care.
Risk factors in endophthalmitis leading to evisceration or enucleation.

BACKGROUND AND OBJECTIVE This study aimed to evaluate the risk factors associated with evisceration or enucleation in endophthalmitis cases. PATIENTS AND METHODS A retrospective analysis was conducted of all cases of endophthalmitis in a single unit over a 10-year period. The cases were divided into two groups. The group 1 consisted of patients with endophthalmitis who underwent evisceration or enucleation. The group 2 included patients with endophthalmitis who recovered with intravitreal injection or vitrectomy. RESULTS During the 10-year study period, 86 patients with endophthalmitis were admitted for treatment. Evisceration or enucleation was undergone by 20 patients (23.2%) (Group 1); Group 2 consisted of 66 patients. Older age (P = 0.03), no light perception at presentation (P < 0.0001), endophthalmitis associated with corneal ulcer (P < 0.0001), and endogenous endophthalmitis (P = 0.048) were statistically significant factors associated with the need for evisceration or enucleation.
Differential Involvement of Multidrug Resistance-Associated Protein 1 and P-Glycoprotein in Tissue Distribution and Excretion of Grepafloxacin in Mice

The involvement of multidrug resistance-associated protein 1 (Mrp1) and P-glycoprotein (mdr1) in the tissue distribution and excretion of grepafloxacin (GPFX), a fluoroquinolone antibiotic, was investigated using gene-deficient mice [mdr1a(–/–), mdr1a/1b(–/–), and mrp1(–/–)]. The plasma concentration-time profile of GPFX in mrp1(–/–) was nearly identical to that in mrp1(+/+), whereas that in mdr1a/1b(–/–) was higher than that in mdr1a/1b(+/+). The urinary clearance of GPFX in mdr1a/1b(–/–) was lower than that in mdr1a/1b(+/+), suggesting that the urinary excretion of GPFX is at least partially mediated by mdr1. The tissue-to-plasma concentration ratios during the β-phase (Kp β,) was significantly higher in the heart, trachea, kidney, spleen, and brown fat of mrp1(–/–) than those in mrp1(+/+). In MRP1-transfected LLC-PK1 cells, the efflux of GPFX after preloading into the cells was higher than that observed in the parent cell lines. These results suggest that GPFX is a substrate of MRP1 and that its distribution to these tissues might be limited by Mrp1. On the other hand, a higher Kp β, and of GPFX in mdr1a(–/–) mdr1a/1b(–/–) compared with mdr1a/1b(+/+) was observed only in the brain. GPFX was efficiently distributed to the lung parenchyma cells and pulmonary airspaces, including the epithelial lining fluid and macrophages that are the pharmacological target of GPFX, although the contribution of Mdr1 and Mrp1 to such distribution seems to be minor. Thus, the present findings reveal that the disposition of GPFX is at least in part governed by these two ABC transporters and that both Mrp1 and Mdr1 are involved in the limited distribution of GPFX to the distinct tissues, including pharmacological and/or toxicological targets by an active efflux mechanism.
A new feature selection IDS based on genetic algorithm and SVM

Intrusion detection systems (IDS) are the main components of network security. IDSs monitor events of a system in a network, analyze the behavior in order to detect intrusions. One of the IDS models is anomaly based IDS which train to distinguish between normal and abnormal traffic. One of the anomaly based IDSs is based on Genetic algorithm as an evolutionary optimization algorithm. This paper has proposed an anomaly based IDS using Genetic algorithm and Support Vector Machine (SVM) with a new feature selection method. The new model has used a feature selection method based on Genetic with an innovation in fitness function reduce the dimension of the data, increase true positive detection and simultaneously decrease false positive detection. In addition, the computation time for training will also have a remarkable reduction. Results show that the proposed method can reach high accuracy and low false positive rate (FPR) simultaneously, though it had earlier been achieved in earlier studies separately. This study proposes a method which can achieve more stable features in comparison with other techniques. The proposed model experiment and test on KDD CUP 99 and UNSW-NB15 datasets. Numeric Results and comparison to other models have been presented.
Global biogeochemical cycle of vanadium

Significance Human emissions of vanadium to atmosphere exceed natural sources by a factor of 1.7 and are destined to rise dramatically as we switch to the use of heavy oils, tar sands, and bitumen as combustion sources. Breathing vanadium-rich aerosols has unknown but potentially adverse health impacts. The human impacts on the global vanadium cycle parallel impacts on the global cycles for Pb and Hg. Synthesizing published data, we provide a quantitative summary of the global biogeochemical cycle of vanadium (V), including both human-derived and natural fluxes. Through mining of V ores (130 × 109 g V/y) and extraction and combustion of fossil fuels (600 × 109 g V/y), humans are the predominant force in the geochemical cycle of V at Earth’s surface. Human emissions of V to the atmosphere are now likely to exceed background emissions by as much as a factor of 1.7, and, presumably, we have altered the deposition of V from the atmosphere by a similar amount. Excessive V in air and water has potential, but poorly documented, consequences for human health. Much of the atmospheric flux probably derives from emissions from the combustion of fossil fuels, but the magnitude of this flux depends on the type of fuel, with relatively low emissions from coal and higher contributions from heavy crude oils, tar sands bitumen, and petroleum coke. Increasing interest in petroleum derived from unconventional deposits is likely to lead to greater emissions of V to the atmosphere in the near future. Our analysis further suggests that the flux of V in rivers has been incremented by about 15% from human activities. Overall, the budget of dissolved V in the oceans is remarkably well balanced—with about 40 × 109 g V/y to 50 × 109 g V/y inputs and outputs, and a mean residence time for dissolved V in seawater of about 130,000 y with respect to inputs from rivers.
An examination of main and interactive effects of substance abuse recovery housing on multiple indicators of adjustment.

AIMS To assess the effectiveness of community-based supports in promoting abstinence from substance use and related problems. DESIGN AND PARTICIPANTS Individuals (n = 150) discharged from residential substance abuse treatment facilities were assigned randomly to either an Oxford House recovery home or usual after-care condition and then interviewed every 6 months for a 24-month period. INTERVENTION Oxford Houses are democratic, self-run recovery homes. MEASUREMENTS Hierarchical linear modeling was used to examine the effect of predictive variables on wave trajectories of substance use, employment, self-regulation and recent criminal charges. Regressions first examined whether predictor variables modeled wave trajectories by condition (Oxford House versus usual after-care), psychiatric comorbidity, age and interactions. FINDINGS At the 24-month follow-up, there was less substance abuse for residents living in Oxford Houses for 6 or more months (15.6%), compared both to participants with less than 6 months (45.7%) or to participants assigned to the usual after-care condition (64.8%). Results also indicated that older residents and younger members living in a house for 6 or more months experienced better outcomes in terms of substance use, employment and self-regulation. CONCLUSIONS Oxford Houses, a type of self-governed recovery setting, appear to stabilize many individuals who have substance abuse histories.