Miracle-dz/UniFAR-FTUs huggingface dataset:
Endovascular Treatment of Internal Carotid Artery Bifurcation Aneurysms: A Single-Center Experience and a Systematic Review and Meta-Analysis

BACKGROUND AND PURPOSE: Endovascular coiling of internal carotid artery bifurcation aneurysms can be challenging due to unfavorable morphologic features. With improvements in endovascular techniques, several series have detailed the results and complications of endovascular treatment of aneurysms at this location. We performed a systematic review and meta-analysis of published series on the endovascular treatment of ICA bifurcation aneurysms, including a tertiary referral center experience. MATERIALS AND METHODS: We performed a comprehensive literature search for reports on contemporary endovascular treatment of ICA bifurcation aneurysms from 2000 to 2013, and we reviewed our experience. We extracted information regarding periprocedural complications, procedure-related morbidity and mortality, immediate angiographic outcome, long-term clinical and angiographic outcome, and retreatment rate. Event rates were pooled across studies by using random-effects meta-analysis. RESULTS: Including our series of 37 patients, 6 studies with 158 patients were analyzed. Approximately 60% of the aneurysms presented as unruptured; 88.0% (95% CI, 68.0%–96.0%) of aneurysms showed complete or near-complete occlusion at immediate postoperative angiography compared with 82.0% (95% CI, 73.0%–88.0%) at last follow-up. The procedure-related morbidity and mortality were 3.0% (95% CI, 1.0%–7.0%) and 3.0% (95% CI, 1.0%–8.0%), respectively. The retreatment rate was 14.0% (95% CI, 8.0%–25.0%). Good neurologic outcome was achieved in 93.0% (95% CI, 86.0%–97.0%) of patients. CONCLUSIONS: Endovascular treatment of ICA bifurcation aneurysms is feasible and effective and is associated with high immediate angiographic occlusion rates. However, retreatment rates and procedure-related morbidity and mortality are non-negligible.
Barriers of Social Entrepreneurship Development – A Case Study of the Czech Republic

ABSTRACT Social entrepreneurship (SE) began to be strongly supported in Central and Eastern European countries during the programming period of 2007–2013. However, the level of SE development still lags behind developed countries. The paper focuses on the identification of barriers to SE development in the Czech Republic and recommendations for policymaking. The value added is the adaptation of the Community of Practice on Inclusive Entrepreneurship methodology and its verification. A limited range of financial support options and a lack of interest of banks to improve the availability of loans were identified as main barriers to the development of SE.
Design complexity and strength of laterality are correlated in New Caledonian crows' pandanus tool manufacture

Population-level laterality is generally considered to reflect functional brain specialization. Consequently, the strength of population-level laterality in manipulatory tasks is predicted to positively correlate with task complexity. This relationship has not been investigated in tool manufacture. Here, we report the correlation between strength of laterality and design complexity in the manufacture of New Caledonian crows' three pandanus tool designs: wide, narrow and stepped designs. We documented indirect evidence of over 5800 tool manufactures on 1232 pandanus trees at 23 sites. We found that the strength of laterality in tool manufacture was correlated with design complexity in three ways: (i) the strongest effect size among the population-level edge biases for each design was for the more complex, stepped design, (ii) the strength of laterality at individual sites was on average greater for the stepped design than it was for the simpler wide and narrow, non-stepped designs, and (iii) there was a positive, but non-significant, trend for a correlation between the strength of laterality and the number of steps on a stepped tool. These three aspects together indicate that greater design complexity generally elicits stronger lateralization of crows' pandanus tool manufacture.
Genome-wide association and epistasis studies unravel the genetic architecture of sudden death syndrome resistance in soybean.

Soybean [Glycine max (L.) Merr. ] is an economically important crop that is grown worldwide. Sudden death syndrome (SDS), caused by Fusarium virguliforme, is one of the top yield-limiting diseases in soybean. However, the genetic basis of SDS resistance, especially with respect to epistatic interactions, is still unclear. To better understand the genetic architecture of soybean SDS resistance, genome-wide association and epistasis studies were performed using a population of 214 germplasm accessions and 31,914 SNPs from the SoySNP50K Illumina Infinium BeadChip. Twelve loci and 12 SNP-SNP interactions associated with SDS resistance were identified at various time points after inoculation. These additive and epistatic loci together explained 24-52% of the phenotypic variance. Disease-resistant, pathogenesis-related and chitin- and wound-responsive genes were identified in the proximity of peak SNPs, including stress-induced receptor-like kinase gene 1 (SIK1), which is pinpointed by a trait-associated SNP and encodes a leucine-rich repeat-containing protein. We report that the proportion of phenotypic variance explained by identified loci may be considerably improved by taking epistatic effects into account. This study shows the necessity of considering epistatic effects in soybean SDS resistance breeding using marker-assisted and genomic selection approaches. Based on our findings, we propose a model for soybean root defense against the SDS pathogen. Our results facilitate identification of the molecular mechanism underlying SDS resistance in soybean, and provide a genetic basis for improvement of soybean SDS resistance through breeding strategies based on additive and epistatic effects.
Evidence for differential effects of apoE3 and apoE4 on HDL metabolism Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200172-JLR200

We present a murine model that examines the effects of macrophage-produced apolipoprotein E3 (apoE3) and apoE4 on VLDL and high density lipoprotein (HDL) metabolism. Mice expressing apoE3 on the Apoe−/− background had substantially lower VLDL levels than mice expressing apoE4. In addition, there were differences between the HDL of apoE3- and apoE4-expressing mice. Apoe−/− mice have low levels of HDL. Low level expression of either apoE3 or apoE4 was able to restore near-normal HDL levels, which increased dramatically when the mice were challenged with a high-fat diet. ApoE4-expressing mice had smaller HDL than apoE3-expressing mice on both chow and high-fat diets. In addition, plasma from apoE4-expressing mice was less efficient at transferring apoA-I from VLDL to HDL and at generating HDL in vitro than that from apoE3-expressing mice. Thus, we present experimental evidence for differential effects of apoE3 and apoE4 on HDL metabolism that supports epidemiological observations made in humans, which suggested that individual homozygous for the ε4 allele had lower HDL than others.
Short Report: Object-Centred Inhibition of Return of Visual Attention

Our response to visual events can be delayed at positions we have recently examined attentively. Such inhibition could organize visual search through static scenes by suppressing those loci already searched, but this mechanism would fail in moving scenes as objects' locations then change during search. We cued attention to a moving object and found subsequent inhibition at the locus the object later occupied. This implies that previously examined objects are suppressed. Such object-centred inhibition would be highly adaptive, but would require a sophisticated neural implementation for a mechanism held to be sub-cortical.
Frequency split metal artifact reduction (FSMAR) in computed tomography.

PURPOSE The problem of metal artifact reduction (MAR) is almost as old as the clinical use of computed tomography itself. When metal implants are present in the field of measurement, severe artifacts degrade the image quality and the diagnostic value of CT images. Up to now, no generally accepted solution to this issue has been found. In this work, a method based on a new MAR concept is presented: frequency split metal artifact reduction (FSMAR). It ensures efficient reduction of metal artifacts at high image quality with enhanced preservation of details close to metal implants. METHODS FSMAR combines a raw data inpainting-based MAR method with an image-based frequency split approach. Many typical methods for metal artifact reduction are inpainting-based MAR methods and simply replace unreliable parts of the projection data, for example, by linear interpolation. Frequency split approaches were used in CT, for example, by combining two reconstruction methods in order to reduce cone-beam artifacts. FSMAR combines the high frequencies of an uncorrected image, where all available data were used for the reconstruction with the more reliable low frequencies of an image which was corrected with an inpainting-based MAR method. The algorithm is tested in combination with normalized metal artifact reduction (NMAR) and with a standard inpainting-based MAR approach. NMAR is a more sophisticated inpainting-based MAR method, which introduces less new artifacts which may result from interpolation errors. A quantitative evaluation was performed using the examples of a simulation of the XCAT phantom and a scan of a spine phantom. Further evaluation includes patients with different types of metal implants: hip prostheses, dental fillings, neurocoil, and spine fixation, which were scanned with a modern clinical dual source CT scanner. RESULTS FSMAR ensures sharp edges and a preservation of anatomical details which is in many cases better than after applying an inpainting-based MAR method only. In contrast to other MAR methods, FSMAR yields images without the usual blurring close to implants. CONCLUSIONS FSMAR should be used together with NMAR, a combination which ensures an accurate correction of both high and low frequencies. The algorithm is computationally inexpensive compared to iterative methods and methods with complex inpainting schemes. No parameters were chosen manually; it is ready for an application in clinical routine.
Canal Clearance in Burst Fractures using the AO Internal Fixator

The purpose of this study was to evaluate the ability of posterior distraction delivered by the AO internal fixator to effect a satisfactory reduction of the intraspinal fragments in burst fractures. The overall decompression achieved was from an initial compromise of 54% to a residual encroachment of 40%. Canal clearance proved most effective when carried out in the first 4 days, with an initial canal compromise of between 34 and 66%. The extent of improvement, even in this group, was not dramatic, with an average of 31% encroachment still remaining, with some cases as high as 50%. Therefore, we recommend that when canal clearance is essential. Anterior decompression is the treatment of choice.
Communication behavior and protest participation in the refugee debate: The role of personal conversations, mass media and social media usage in citizen participation

Beginning in summer 2015, the increasing number of refugees coming to Europe and the question of how to handle this challenge has ignited a heated public debate in many European countries. In Germany, public discourse has become progressively intense, and on both sides of the controversy, citizens have attempted to actively influence and to shape the public debate through their actions. Against this background, this paper examines whether or not personal conversations, mass media and social media usage make it more likely for citizens to participate in the public debate on refugees. To do this, an online survey (N= 1,579) was conducted in February 2016, in the midst of the German refugee debate. The results show that different sources of information and forms of communication related to refugees may either foster or hinder people’s participation in a public demonstration against or in support of refugees.
Treatment outcome of diffuse large B-cell lymphoma involving the head and neck

Abstract This study was performed to analyze the treatment outcome for diffuse large B-cell lymphoma (DLBCL) involving the head and neck and to evaluate the role of radiotherapy in the rituximab era. Fifty-six patients diagnosed with DLBCL involving the head and neck were assessed. All patients were treated with 6 cycles of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone (R-CHOP). After chemotherapy, radiation was delivered to the head and neck area in a median dose of 36 Gy. Radiation was delivered using 3-dimensional radiotherapy (n = 25) or intensity-modulated radiotherapy (n = 31). Primary endpoints were relapse-free survival (RFS), overall survival (OS), and local control rate. After median follow-up time of 45 months, the 5-year RFS and OS rates were 72% and 61%, respectively. Fourteen (25%) of 56 patients relapsed; 1 had a local relapse, 11 had distant relapses, and 2 had both local and distant relapses. The final local control rate after radiotherapy was 94%. Age, performance status, international prognostic index score, and radiotherapy response were significant prognostic factors for both RFS and OS in the multivariate analysis. Incidence of acute grade 3 and 4 hematologic toxicity was 9% and 4%, respectively. Grade 3 nonhematologic toxicity occurred in 2 (4%) patients, and there was no grade 4 nonhematologic toxicity for the irradiated patients. Excellent local control and survival rates can be achieved with R-CHOP followed by radiotherapy in patients with DLBCL involving the head and neck. Treatment-related toxicity after the introduction of modern radiotherapy was acceptable and limited.
cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies.

BACKGROUND Polymyositis (PM) and dermatomyositis (DM) are complex human diseases of autoimmune origin which cause progressive skeletal muscle weakness in adults and children. Histopathological studies of affected muscles suggest that cytotoxic T cell-induced injury predominates in PM, while humoral immune mechanisms seem more likely in DM. Early expression of MHC class I molecules on myocytes is a striking feature of both disorders. This study was to use gene microarray analysis of muscle biopsies from PM and DM patients to obtain a comprehensive view of molecules participating in disease pathogenesis. MATERIAL/METHODS Muscle biopsies from 10 patients (6 PM and 4 DM) and 5 controls were selected for gene expression profiles. Microarray filters containing 4000 known human genes were used to hybridize with RNAs from muscle biopsies. Real-time RT-PCR assays were used to confirmed selected genes that showed changes in expression levels in PM and DM from microarray data. The t-statistic was used to measure any differences in the amount of gene expression in the normal versus myositis biopsies. RESULTS Forty genes clustering into two major groups showed significantly altered expression levels in PM/DM compared to normal biopsies. One cluster of over-expressed genes was primarily of immune origin and included HLA-class I and II, interferon-inducible proteins, natural killer (NK) protein, immunoglobulins and complement. The other cluster of under-expressed genes were of muscle origin, especially those involved in the fast twitch response. PM and DM gene profiles appeared similar. CONCLUSIONS PM and DM muscle biopsies show similar gene expression profiles despite reported differences in histopathological changes. Altered gene expressions of immune regulation and myofibrillar proteins are prominent in muscle biopsies of myositis.
Mitomycin-induced synthesis of a Shiga-like toxin from enteropathogenic Escherichia coli H.I.8

Escherichia coli H.I. 8, an O128 infant diarrhea isolate, produces low titers of a unique Shiga-like toxin (SLT), called SLT-IIva, which is a variant of SLT-II. We investigated induction of toxin synthesis and the putative association of a bacteriophage with toxin synthesis. Induction of broth cultures of strain H.I. 8 with mitomycin yielded a 3,000-fold increase in SLT-IIva, production of a colicin, and appearance of a bacteriophage. Southern hybridization demonstrated that the genes for SLT-IIva were not carried by the bacteriophage.
Computation offloading in cloud-RAN based mobile cloud computing system

The cloud radio access network (Cloud-RAN) based mobile cloud computing (MCC) system offers a promising solution to offload computation-intensive tasks from battery and computation capability limited mobile devices to a cloud service provider via wireless transmission, thereby reducing the energy consumption and latency for mobile devices. However, the extra energy and latency caused by wireless transmission for offloading may offset the gains of computation offloading. In this paper, we focus on minimizing the network energy consumption while satisfying the delay requirements by jointly optimizing the communication resources (i.e., uplink and downlink beamforming design), computation resources (i.e., computation capability) and offloading decision (i.e., offload or not offload). Unfortunately, this problem turns out to be an NP-hard non-convex mixed integer non-linear programming (MINLP) problem. To resolve this challenge, the principle of uplink and downlink duality is exploited to aid efficient beamforming design. Furthermore, an effective iterative algorithm with polynomial time complexity is proposed in a holistic way to guide the offloading decision. Simulation results will demonstrate that the proposed iterative algorithm achieves near-optimal energy efficiency in Cloud-RAN based mobile cloud computing system.
Platelet-rich plasma provides nucleus for mineralization in cultures of partially differentiated periodontal ligament cells

SummaryPlatelet-rich plasma (PRP) has been used to promote periodontal regeneration following the premise that constituent transforming growth factor-β1 (TGF-β1) and platelet-derived growth factor-AB will stimulate cell proliferation at the site of application. In previous studies, we demonstrated that PRP mimics TGF-β1 to modulate proliferation in a cell type-specific manner, that fibrin clot formation by PRP upregulates type I collagen, and that an unidentified factor(s) in PRP increases alkaline phosphatase (ALP) activity in human periodontal ligament (PDL) cell cultures. We have now examined the effects of PRP on in vitro mineralization. Platelet-rich plasma and PDL cells were prepared from human adult volunteers or rats. After 20 d of continuous treatment with PRP in dexamethazone (Dex)-containing osteogenic medium, PRP time dependently promoted mineralization by rat PDL cells but failed to fully induce the osteoblastic phenotype. Furthermore, when human PDL cells were induced to increase ALP activity in osteogenic medium that lacked Dex, a condition that should delay (or suppress) osteoblastic differentiation, transmission electron microscopy revealed that mineralized spicules were initially deposited onto PRP-derived platelet aggregates. Taken together with our previous data, these findings suggest that PRP provides platelet aggregates as nuclei to initiate mineralization while stimulating PDL cell proliferation, differentiation, and collagen production. The combination of these effects may effectively mediate PRP's ability to promote regeneration of periodontal tissue, including skeletal tissue, at the site of injury.
Sensitization to Malassezia in children with atopic dermatitis combined with food allergy

The yeast Malassezia belongs to our normal cutaneous flora, but is capable of sensitizing individuals with atopic dermatitis (AD). Our objective was to investigate the prevalence of sensitization to Malassezia with a 10‐yr follow‐up among children suffering from AD combined with food allergy (FA) in relation to the extent of AD in infancy.
Efficacy and Potency of Antivenoms in Neutralizing the Procoagulant Effects of Australian Snake Venoms in Dog and Human Plasma

The efficacy and potency of Commonwealth Serum Laboratories (CSL) snake antivenoms in neutralizing the procoagulant action of Australian snake venoms was studied in vitro. The procoagulant action of venoms from Tiger, Brown and Taipan Snakes were measured in pooled canine or pooled human plasma. Mixtures of the venoms and their appropriate antivenoms, ranging from 0.1 to 15 times the recommended neutralizing dose of antivenom were then added to pooled canine or pooled human plasma and the efficacy and potency of the antivenoms in preventing the procoagulant action was measured. Neutralization was achieved by the addition of the appropriate antivenom in concentrations of 0.5 (Taipan), 10 (Tiger), 10 (Gwardar), 15 (Dugite) and an estimated 20 (Common Brown) times the dose expected. Similar results were obtained in canine and human plasma. The potency of Tiger and especially Brown Snake antivenom is substantially lower (10–20 times) than that predicted by CSL. These findings support an increase in the dose of antivenom to be used for the treatment of Tiger and especially Brown Snake envenomation complicated by coagulopathy. The in vitro canine model may be suitable for studying the procoagulant effects of Australian snake venoms.
Establishment Dynamics, Vacancies, and Unemployment: A Neoclassical Approach

This article introduces and analyzes a Walrasian model of worker flows, job flows, vacancies, and unemployment. Calibrating the model to U.S. data, the article finds that all variables comove with output quite well but that they fluctuate too little. However, the failure is not as bad as in “Shimer's puzzle. ” Interestingly, the article also finds that introducing establishment dynamics into the model, while realistic, is irrelevant for understanding unemployment and vacancy fluctuations: The business cycles of the model with establishment dynamics are virtually the same as those of a version with a representative firm.
Creation and Validation of a Photonumeric Scale to Assess Volume Deficiency in the Infraorbital Region

BACKGROUND The eyes are particularly important aesthetic features of the face and revitalization of the infraorbital region has become a focus of aesthetic treatments. Published infraorbital scales to date have limitations in that they have been descriptive, subjective, or have used computer-generated images. Thus, there is an unmet need for a validated scale based on actual images. OBJECTIVE To develop a practical photonumeric scale that respects the complex anatomy and age-related changes occurring in the orbital area. METHODS AND MATERIALS The Allergan Infra-oRbital Scale (AIRS) was developed through a multistep process in collaboration with 16 physicians (plastic surgeons, dermatologists, and aesthetic physicians). Scale development involved both online photographs and live assessments of subjects. Interrater and intrarater reliability was assessed using intraclass correlation coefficients (ICCs). RESULTS The final AIRS showed intrarater and interrater ICCs of 0.78 to 0.86 and 0.91 to 0.98 for live validation and 0.76 to 0.82 and 0.86 to 0.91 for online validation, respectively, demonstrating robust validity. CONCLUSION The AIRS can be considered a photonumeric scale that accurately describes volume loss in the infraorbital region. It has been validated and is appropriate for use in research or for everyday clinical use for both live and photographic assessment.