Miracle-dz/UniFAR-FTUs huggingface dataset:
An aggressive rare entity - Pure (de novo) primary squamous cell carcinoma of ovary: Review of literature and a case report

Ovarian cancers are commonly diagnosed gynecological malignancies worldwide. It ranks among the top ten diagnosed cancers and top five deadliest cancers in most countries. However, in spite of this squamous cell carcinoma (SCC) of the ovary is extremely rare. Here, we present a review of the literature along with a case of a 66-year-old postmenopausal female who presented with swelling, pain abdomen with constipation, and weight loss. She was diagnosed with pure (de novo) primary SCC of left ovary. No pre/co-existing ovarian lesion was identified. Despite external radiation and adjuvant chemotherapy, the patient died in 2 months.
Herbivory and Competing Vegetation Interact as Site Limiting Factors in Maritime Forest Restoration

Herbivory and competition during the regeneration phase influence forest successional dynamics. We demonstrated the importance of using the Target Plant Concept to identify and overcome site limiting factors for subtropical maritime forest restoration associated with deer browsing and competition. Quercus virginiana Mill. (live oak) bareroot seedlings were planted into clearcuts along the US Southern Atlantic coast with different treatment combinations of herbivory control (fenced or non-fenced) against white-tailed deer (Odocoileus virginianus Zimm.) browsing and competing vegetation removal (none, one-year, or two-years). After three growing seasons, mean seedling survival was 61% with no significant treatment differences. Control of browse and vegetation interacted to facilitate growth of live oak; seedlings were significantly larger for all response parameters (diameter, height, crown width) when fenced and treated with vegetation control. Removal of vegetation improved seedling performance only in fenced plots, however, indicating a shift in pressure from herbivory to competition as the most limiting site factor when deer were excluded. After the second growing season, foliar nitrogen was greater in fenced plots than non-fenced plots and greater in two-year vegetation control subplots than non-vegetation control subplots. This result, however, was absent after the third growing season. Three years after clearcutting, there was no evidence of Q. virginiana natural regeneration in non-fenced plots. Even with artificial regeneration in non-fenced plots, Q. virginiana growth was slow, indicating that herbivory was a key limiting factor. Our findings illustrate the importance of accounting for site limiting factors and may aid in developing management prescriptions to promote semi-evergreen oak regeneration in ecosystems with high pressure from herbivory and competing vegetation.
Complex refractive indices of secondary organic material

Ultraviolet and visible complex refractive indices of secondary organic material produced by photooxidation of the aromatic compounds toluene and m-Xylene P. F. Liu, N. Abdelmalki, H. -M. Hung, Y. Wang, W. H. Brune, and S. T. Martin School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA Department of Atmospheric Sciences, National Taiwan University, Taipei, Taiwan Department of Meteorology, Pennsylvania State University, University Park, PA, USA Department of Earth and Planetary Sciences, Harvard University, Cambridge, MA, USA
Incidence and Risk of Thyroid Dysfunction in Advanced or Metastatic Non-small Cell Lung Cancer Patients Treated with Pembrolizumab: A Meta-analysis

Thyroid dysfunction is one of the major side effects associated with Pembrolizumab in the treatment of advanced or metastatic non-small cell lung cancer (NSCLC). We performed a systematic review and meta-analysis of randomized clinical trials to determine its overall incidence. A literature search was conducted using the electronic database engines PubMed and Google Scholar from inception to March 2019. Eligible studies were prospective randomized clinical trials with advanced or metastatic NSCLC. The pooled incidence, risk ratio (RR), and 95% confidence interval (CI) of thyroid dysfunction were calculated using the random-effect model. Given the possibility of a between-study variance, we used the random-effect model rather than the fixed-effect model. A total of four studies, including 1603 patients, were selected for analysis. Among patients receiving Pembrolizumab, the overall incidence of all-grade thyroid dysfunction was 19.8% (95% CI: 16.6-23.3%). Pembrolizumab was associated with a significantly increased risk of thyroid dysfunction of all grades, with a relative risk of 3.9 (95% CI: 2.08-7.42%, p= 0.084) in comparison with the controls. Therefore, there is a significant increase in developing thyroid dysfunction in advanced or metastatic NSCLC patients treated with Pembrolizumab.
LIFO-Backpressure achieves near optimal utility-delay tradeoff

There has been considerable recent work developing a new stochastic network utility maximization framework using Backpressure algorithms, also known as MaxWeight. A key open problem has been the development of utility-optimal algorithms that are also delay efficient. In this paper, we show that the Backpressure algorithm, when combined with the LIFO queueing discipline (called LIFO-Backpressure), is able to achieve a utility that is within O(1/V) of the optimal value for any scalar V ≥ 1, while maintaining an average delay of O([log(V)]2) for all but a tiny fraction of the network traffic. This result holds for general stochastic network optimization problems and general Markovian dynamics. Remarkably, the performance of LIFO-Backpressure can be achieved by simply changing the queueing discipline; it requires no other modifications of the original Backpressure algorithm. We validate the results through empirical measurements from a sensor network testbed, which show good match between theory and practice.
Public-key cryptography and password protocols

where the dent end does not possess apubfic keyi. The first work toderdwith theuseofpubhc key techWe study protocok for strong authentication and key exchange in asymmetric scenarios where the authentication niques in conjunction with password authentication was by Gong, Lomas, Needham and Srdtzer [II]. k that paper, it server possesses a pair of privat e and pubhc keys wMe the dent has ordy a weak human-memotiable password as its was suggested that by providing the authentication server with a pair of private/pubfic keys one codd protect weak huauthentication key. We present and analyze several simple man passwords against strong attacks via the use of pubhc password protocok in this scenario, and show that under the key encryption. choice of suitable pubtic key encryption functions the secuThe emphasis of that work was in protecting passwords rity of these protocok can be forrndy proven based on stanagainst off-be password-guessing attacks, which is a comdard cryptographic assumptions. b partictiar, our analysis mon and powerfti attack that takes advantage of the low shows optimal resistance to off-kc password guessing atentropy atiable in user-chosen passwords. This attack pr~ tacks. k addition to user authentication, we enhance our ceeds by trying to guess the password and verify the guessed protocok to provide tw~way authentication, authenticated due using pub~dy adable information, such as the trankey exchange, defense against server’s compromise, and user script of a legitimate authentication session between the user anonymity. We complement these restits with a proof that and server. This attack k very powerfrd, since it can be perpubfic key techniques are unavoidable for p~sword prot~ formed off-be, so the attacker does not need to interact cok that resist off-be guessing attacks. As a further contribution, we introduce the notion of pubwith the legitimate parties, and can use a lot of computing lic passwords that dow for the use of such protocok in sitpower. (h contrast, on-be attacks where the attacker activdy tries tierent passwords against the server are easy to uations where the Aent’s machine does not have the means detect and tit.) Our work extends the pubfic key based to *date the server’s pubhc key. PubEc passwords serve approach of [11] in several ways. as ‘hand-hdd certficatesm that the user can carry without the need for speard computing devices. ● We consider several simple and intuitive protocok for password authentication, and formfly analyze their
Efficient dataflow analysis of logic programs

We investigate a framework for efficient flow analyses of logic programs. A major problem in this context is that unification can give rise to aliasing and dependencies between variables whose effects are difficult to predict, and which make sound flow analysis algorithms computationally expensive. We give a simple characterization of the class of flow analysis problems for which aliasing effects can be ignored without loss of soundness, and describe an efficient analysis procedure for this class of problems. The utility of our approach is illustrated by discussing its application to several analysis and optimization problems for logic programs. Our results are useful in the design of efficient flow analysis systems for logic programming languages.
Effect of Modified Thai Yoga on Energy Cost and Metabolic Intensity in Obese Older Adult Thai Women

Introduction: Obesity is associated with increased risk of chronic diseases. An increasing of physical activity can prevent the obesity and improve the daily life quality in older adults. The purpose of this study was to investigate the effect of modified Thai Yoga on metabolic intensity and energy expenditure in obese older adult Thai women. Material and methods: Twenty-six participants, aged 56-75 years old, were divided into two groups: non-obese group (NB) and obese group (OB) defined by their body mass index. After 12 sessions of familiarization, the participants performed the modified Thai Yoga exercise program for 60 minutes. Energy expenditure and metabolic variables were measured via open circuit calorimetry. Results: At the exercise phase, the mean percentage of maximum heart rate for the OB and NB groups were OB: 57.43±6.32 % and 59.89±7.94%, respectively. The mean oxygen consumption for the OB group was 7.52±1.09 ml/min/kg as compared to the NB group which was 8.44±0.90 ml/min/kg. The mean metabolic equivalent (MET) for the OB group was 2.15±0.31 MET as compared to 2.41±0.26 MET for the NB group. Total energy expenditure for the OB and NB groups were 3531.32±483.47 kcal/day and 3090.82±387.99 kcal/day, respectively. The mean of activity energy expenditure for the OB group was 1509.65±498.72 kcal/day and 1393.39±367.41 kcal/day for the NB group. The difference between all parameters measured from OB and NB groups were significant (p<0.05). Conclusions: These results demonstrated that this modified Thai Yoga program provides a well-tolerated light intensity exercise stimulus and could be prescribed as an exercise program for obese older adults. yoga, obesity, aged women, energy expenditure, metabolic equivalent email: waree.widjaja@yahoo.com The research was financed from the authors’ own resources Rehabilitation Advances in Rehabilitation/Postępy Rehabilitacji (3), 47–54, 2019 A – preparing concepts B – formulating methods C – conducting research D – processing results E – interpretation and
CPAA_A_193191 93..101

Abhijeet Jakate Brian McNamee Donald Burkindine 1Clinical Pharmacology, Allergan plc, Madison, NJ, USA; 2Clinical Pharmacology, Allergan Biologics Ltd, Liverpool, UK; 3QPS Bio-Kinetic, Springfield, MO, USA Objective: Delayed-release mesalamine 400 mg capsules containing four 100 mg tablets have been developed for children with ulcerative colitis who have difficulty swallowing. Bioavailability of the mesalamine capsules was compared with existing mesalamine tablets in healthy adults, and the effect of food on bioavailability from mesalamine capsules was determined. Tablet swallowability in healthy children was evaluated. Methods: In the open-label, replicate-treatment, single-dose, crossover, comparative bioavailability study, healthy adult volunteers were randomized to one of four treatment sequences to receive mesalamine 400 mg tablets (fasted) twice, mesalamine 400 mg capsules (fasted) twice, and a mesalamine 400 mg capsule (with food) once, with ≥7 days between treatments. Pharmacokinetic (PK) parameters were calculated and analyzed using the reference-scaled average bioequivalence procedure. In the open-label, single-dose swallowability study, healthy children aged 5–11 years were asked to swallow eight placebo tablets identical to those contained in two mesalamine capsules. Results: In the bioavailability study (n=160), mesalamine capsules and tablets in fasted volunteers exhibited similarly delayed absorption and were shown to be bioequivalent; statistical parameters calculated from PK values met the criteria for bioequivalence. A slight increase in mesalamine bioavailability was observed with food administration, but the delayed-release performance of the capsules was not affected. Overall safety profiles between capsules and tablets were similar. In the swallowability study (n=60), the majority of children swallowed eight placebo tablets, with slight variability between age groups. Conclusion: Evaluation of PK parameters confirmed mesalamine capsules are bioequivalent to mesalamine tablets. Mesalamine capsules were well tolerated, can be administered with or without food, and are an age-appropriate product for children.
Model M Lite: A Fast Class-Based Language Model

While advanced language models such as neural network language models and Model M have achieved superior performance as compared to word n-gram models, they are generally much more expensive computationally to train and to decode with. As a result, word n-gram models remain dominant in real-world speech recognition applications. In this paper, we investigate whether it is possible to design a language model with similar performance to Model M that can be trained and applied with similar expense as a word n-gram model. We propose Model M Lite, an ensemble of class-based back-off n-gram models that contains a similar set of n-gram features as Model M. The ensemble of models can be stored compactly and is only slightly larger than a comparable Model M. We evaluate several schemes for dynamically choosing interpolation weights for the ensemble members. On a Wall Street Journal task, our new model achieves 73% to 92% of the absolute gain in word-error rate of a 4-gram Model M as compared to a word 4-gram model, translating to an absolute gain of up to 2% over the baseline.
Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice following Escherichia coli Infection through the Mitochondrial Apoptotic Pathway

Escherichia coli (E. coli) is one of pathogens causing nosocomial pneumonia and could induce pulmonary excessive apoptosis. Although much has been learned about metabolic diseases induced by obesity, the information linking bacterial pneumonia to obesity is limited. Accordingly, we investigated the apoptosis of normal (lean) and diet-induced obesity (DIO, fed a high-fat diet) mice after nasal instillation with E. coli. Lung tissues were obtained at 0 (preinfection), 12, 24, and 72 h after infection, and acute pulmonary inflammation was observed at 12 h. Elevated cell apoptosis and percentage of pulmonary cells depolarized with collapse of the mitochondrial transmembrane potential (Δψm) occurred in response to bacterial infection. The relative mRNA and protein expressions of Bax, caspase-3, and caspase-9 increased, but Bcl-2 decreased in the lung. Interestingly, the apoptotic percentage and most of apoptosis-associated factors mentioned above peaked at 12 or 24 h in the lean-E. coli group, while at 24 or 72 h in the DIO-E. coli group. Taken together, these findings indicated that the E. coli pneumonia caused excessive pulmonary apoptosis through the mitochondria-mediated pathway, and the apoptosis was delayed in the DIO mice with E. coli pneumonia.
Risk Factors, Clinical Presentation and Management of 62 Cases of Ectopic Pregnancy at Tertiary Care Centre

OBJECTIVE: To observe the risk factors, clinical pattern and management of ectopic pregnancy. DESIGN: Descriptive observational study. PLACE AND DURATION: Gynecological Unit II, Liaquat University of Medical and Health Sciences, Hyderabad from January 1 st 2006 to April 1 st 2008. PATIENTS & METHODS: All patients with confirmed diagnosis of ectopic pregnancy were included in the study. A pre-formed proforma was used to record the details about the demographic features, pre-existing risk factors for ectopic pregnancy, clinical features at presentation, management and findings at surgery. Data fed to SPSS program version 11 to analyse the results in terms of frequency and percentages. RESULTS: Total maternity admissions were 8016 with 62 cases of ectopic pregnancy giving an incidence of 0.8% or 1:129. Mean age was 24 years. Majority of the patients were of low parity (n=34, 54.8%). Pelvic inflammatory disease (n=22, 35.4%), previous abdomino pelvic surgery (n=16, 26%), previous ectopic (n=4, 6.4%) and infertility (n=22, 35.4%) were seen as the major risk factors. Regarding the clinical pattern; abdominal pain, amenorrhea and collapse appeared as the common clinical presentations. All patients required surgery. Open laparotomy was performed in 56 (90.3%) cases while 6 (9.7%) patients managed laparoscopically. None of the patients found suitable for conservative or medical management. There was no maternal death related to ectopic pregnancy and the postoperative recovery was uneventful. CONCLUSION: The classic clinical pattern of amenorrhea and abdominal pain was lacking in most of the cases with ectopic pregnancy and there were initial diagnostic difficulties. Pelvic inflammatory disease and history of infertility were the main risk factors. Due to the delay in making diagnosis at early stage, open surgery was required in all cases. This emphasizes the importance of a thorough clinical evaluation and appropriate investigations for patients with high suspicious to benefit our poor patients by the use of recent therapeutic modalities
Theoretical Converter Power Density Limits for Forced Convection Cooling

Power density, defined as ratio of converter output power and converter volume, is an important parameter characterizing the compactness of power electronic systems. Employing water-cooling, converters in the kW-range with power densities up to 10kW/liter have already been built. Higher power densities up to 50kW/liter are under discussion. There is often a desire to employ air-cooling instead of water cooling. In this paper the theoretical converter power density limits for forced convection cooling are investigated. Since the cooling system contributes significantly to the overall converter volume, the paper is restricted to an investigation of the cooling system. The main idea is to increase the power semiconductor junction temperature and, therefore, the heat sink temperature in order to make the heat transfer via forced convection much more effective, thus resulting in a smaller heat sink. This beneficial effect of higher temperatures is partly offset by increased system losses and reduced efficiency. To design thermally optimized heat sinks for today’s commercially available fans is shown to be one key to a converter system optimized in terms of power density. It is shown that by employing SiC-devices, power densities of the converter’s cooling system (not of the whole converter system) of up to 83kW/liter are possible for forced air-cooling.
Biocontrol of Root-Knot Nematode Meloidogyne incognita by Chitinolytic Trichoderma spp.

The inhibitory potential of chitinolytic Trichoderma spp. was assayed against Meloidogyne incognita in vitro and in vivo. Sixteen Trichoderma isolates were assayed for chitinase activity using basal solid medium supplemented with colloidal chitin. Isolates recorded high chitinolytic activity were identified morphologically as Trichoderma asperelloides, T. hamatum, T. harzianum and T. viride. The four species were quantitatively assayed for total and specific chitinase activity. T. asperelloides showed maximum chitinase activity (1.736 U/mL). In vitro studies revealed that egg hatching and second juveniles vitality of root-knot nematodes were significantly inhibited by chitinase-containing growth culture of the four selected chitinolytic Trichoderma species. However, the reduction effect was directly correlated with the concentration of fungal growth suspension. Under greenhouse conditions, three sequentially treatments of soil with homogenized culture suspension were studied. Trichoderma species significantly reduced the final nematode population by 97.81% and root galling by 92.81%. Moreover, all tested Trichoderma species obviously promoted tomato growth compared to untreated control. Significant positive correlation between the biocontrol efficacy of Trichoderma species against root-knot nematodes and their chitinolytic activity was confirmed. The most potential chitinolytic species, T. asperelloides, also recorded the highest biocontrol activity against M. incognita.
Franco Modigliani and the Life Cycle Theory of Consumption

This paper reviews and discusses the contribution by Franco Modigliani to macroeconomic model building for economist forecasting and policy making. As Paul Samuelson observed, Modigliani's theoretical work was fundamental in the development of the basic framework within which the "post-Keynesian eclecticism" of the later twentieth century developed. In the move from theory to practice two aspects of Modigliani's work are considered: 1) the systemic approach that focuses on the relationship between the short and the long term, 2) the special reference to the mechanism of monetary policy transmission in the use of the macroeconomic model for economic stabilisation policy. What is left today of this contribution is finally briefly discussed, also with reference to some recent proposals on macroeconomic model building.
Assessment of Metals Enrichment Arable Soils in the Vicinity of Iron Smelting Company Using Aluminum as a Crustal Reference Element, Katsina State, Nigeria.

Microwave Plasma-Atomic Emission Spectrophotometer (MP-AES) was used to evaluate lead, cadmium, chromium and zinc enrichment or depletion of arable soils in the area of Dana Steel Limited. The gathered ground specimens were digested using a conc. combination. HNO3, conc. HF and 30% H 2 O 2 solution in the 4:3:2 ratios. Electrometric technique determined the pH of the samples and soil textural classification was performed using the technique of the hydrometer. The findings showed that zinc (5-1050 mg / kg); cadmium (0.2-4.0 mg / kg); lead (4-60 mg / kg) and chromium (5-87 mg / kg) ranged from the levels of chosen metals in soil samples. The sample pH ranged from 6.20-7.03 and the findings showed a mildly acidic soil. Determination of enrichment or depletion rate using the technique of enrichment factor and aluminum as a crustal reference component showed that the soil is contaminated with zinc, cadmium and lead, but not chromium-contaminated. This requires instant and appropriate remediation methods to prevent harm to plants, livestock and humans as a whole. Keywords: MP-AES; remediation; metals and Dana steel