Miracle-dz/UniFAR-FTUs huggingface dataset:
Computationally Efficient Measures of Internal Neuron Importance

The challenge of assigning importance to individual neurons in a network is of interest when interpreting deep learning models. In recent work, Dhamdhere et al. proposed Total Conductance, a "natural refinement of Integrated Gradients" for attributing importance to internal neurons. Unfortunately, the authors found that calculating conductance in tensorflow required the addition of several custom gradient operators and did not scale well. In this work, we show that the formula for Total Conductance is mathematically equivalent to Path Integrated Gradients computed on a hidden layer in the network. We provide a scalable implementation of Total Conductance using standard tensorflow gradient operators that we call Neuron Integrated Gradients. We compare Neuron Integrated Gradients to DeepLIFT, a pre-existing computationally efficient approach that is applicable to calculating internal neuron importance. We find that DeepLIFT produces strong empirical results and is faster to compute, but because it lacks the theoretical properties of Neuron Integrated Gradients, it may not always be preferred in practice. Colab notebook reproducing results: this http URL
New insights into plant cell walls by vibrational microspectroscopy

ABSTRACT Vibrational spectroscopy provides non-destructively the molecular fingerprint of plant cells in the native state. In combination with microscopy, the chemical composition can be followed in context with the microstructure, and due to the non-destructive application, in-situ studies of changes during, e.g., degradation or mechanical load are possible. The two complementary vibrational microspectroscopic approaches, Fourier-Transform Infrared (FT-IR) Microspectroscopy and Confocal Raman spectroscopy, are based on different physical principles and the resulting different drawbacks and advantages in plant applications are reviewed. Examples for FT-IR and Raman microscopy applications on plant cell walls, including imaging as well as in-situ studies, are shown to have high potential to get a deeper understanding of structure–function relationships as well as biological processes and technical treatments. Both probe numerous different molecular vibrations of all components at once and thus result in spectra with many overlapping bands, a challenge for assignment and interpretation. With the help of multivariate unmixing methods (e.g., vertex components analysis), the most pure components can be revealed and their distribution mapped, even tiny layers and structures (250 nm). Instrumental as well as data analysis progresses make both microspectroscopic methods more and more promising tools in plant cell wall research.
Mobility Challenges for Unmanned Aerial Vehicles Connected to Cellular LTE Networks

Mobility performance is at the heart of each cellular technology, including omni-present LTE networks. It becomes even more significant when such system is supposed to reliably support state-of-the-art devices, such as Unmanned Aerial Vehicles (UAVs), emerging at rapid pace in our surroundings. Contemporary network deployments, addressing mainly the needs of terrestrial users, were not optimized to serve UAVs moving below and above the typical cellular antenna heights. Thus, it is worth checking how they can handle these novel and distinctive services, also with respect to mobility robustness. This paper elaborates on the challenges ahead which must be tackled to make existing LTE networks sufficiently capable of accommodating Aerial Vehicles. We present simulation results in various environments, obtained for different user equipment's (UE's) heights and velocities. Furthermore, we describe and analyze the identified issues. Finally, we also suggest potential optimizations and future research goals.
Gender Trouble in Social Psychology: How Can Butler’s Work Inform Experimental Social Psychologists’ Conceptualization of Gender?

A quarter of a century ago, philosopher Judith Butler (1990) called upon society to create “gender trouble” by disrupting the binary view of sex, gender, and sexuality. She argued that gender, rather than being an essential quality following from biological sex, or an inherent identity, is an act which grows out of, reinforces, and is reinforced by, societal norms and creates the illusion of binary sex. Despite the fact that Butler’s philosophical approach to understanding gender has many resonances with a large body of gender research being conducted by social psychologists, little theorizing and research within experimental social psychology has drawn directly on Butler’s ideas. In this paper, we will discuss how Butler’s ideas can add to experimental social psychologists’ understanding of gender. We describe the Butler’s ideas from Gender Trouble and discuss the ways in which they fit with current conceptualizations of gender in experimental social psychology. We then propose a series of new research questions that arise from this integration of Butler’s work and the social psychological literature. Finally, we suggest a number of concrete ways in which experimental social psychologists can incorporate notions of gender performativity and gender trouble into the ways in which they research gender.
An Investigation on the AC Dielectric Strength of Paper Sheet Insulation in Liquid Nitrogen

In this paper, seven groups of sheet insulation for use in liquid nitrogen immersed power transformers have been tested under three different standard electrodes from ASTM D149-97a. The seven groups consist of three different types of paper/film, nonadhesive Kapton 100 HN (Kapton), THERNOMID 14.20 paper (NMN), and Nomex 410 paper (Nomex). The porous paper, Nomex 410, is found to have ac dielectric strength of 62–68 kV/mm, which is likely to be independent from its thickness. The nonporous film, Kapton, shows the dielectric strength of 288 kV/mm, whereas NMN paper has a dielectric strength of 74–78 kV/mm, larger than Nomex with similar thickness. Liquid nitrogen gaps near the triple junction of electrodes as well as liquid nitrogen pockets between the fibers are the main sources of partial discharge (PD) for NMN and Nomex. For Kapton, PDs are more likely to occur in the cavities filled with liquid nitrogen, either on the surface of the electrode or around the impurities on the surface of the film. Electrodes with a small stressed volume are more appropriate for dielectric tests of thin paper/film insulation, such as Kapton, due to the lower influence of cavities on the electrode surface. In contrast, electrodes with a large stressed volume and uniform electric field distribution are suitable for the papers such as Nomex and NMN.
Pythia v0.1: the Winning Entry to the VQA Challenge 2018

This document describes Pythia v0.1, the winning entry from Facebook AI Research (FAIR)'s A-STAR team to the VQA Challenge 2018. Our starting point is a modular re-implementation of the bottom-up top-down (up-down) model. We demonstrate that by making subtle but important changes to the model architecture and the learning rate schedule, fine-tuning image features, and adding data augmentation, we can significantly improve the performance of the up-down model on VQA v2.0 dataset -- from 65.67% to 70.22%. Furthermore, by using a diverse ensemble of models trained with different features and on different datasets, we are able to significantly improve over the 'standard' way of ensembling (i.e. same model with different random seeds) by 1.31%. Overall, we achieve 72.27% on the test-std split of the VQA v2.0 dataset. Our code in its entirety (training, evaluation, data-augmentation, ensembling) and pre-trained models are publicly available at: this https URL
Effects of Degradations on Deep Neural Network Architectures

Recently, image classification methods based on capsules (groups of neurons) and a novel dynamic routing protocol are proposed. The methods show promising performances than the state-of-the-art CNN-based models in some of the existing datasets. However, the behavior of capsule-based models and CNN-based models are largely unknown in presence of noise. So it is important to study the performance of these models under various noises. In this paper, we demonstrate the effect of image degradations on deep neural network architectures for image classification task. We select six widely used CNN architectures to analyse their performances for image classification task on datasets of various distortions. Our work has three main contributions: 1) we observe the effects of degradations on different CNN models; 2) accordingly, we propose a network setup that can enhance the robustness of any CNN architecture for certain degradations, and 3) we propose a new capsule network that achieves high recognition accuracy. To the best of our knowledge, this is the first study on the performance of CapsuleNet (CapsNet) and other state-of-the-art CNN architectures under different types of image degradations. Also, our datasets and source code are available publicly to the researchers.
The Way We Do the Things We Do: How Cognitive Contexts Shape the Neural Dynamics of Motor Areas in Humans

In spontaneously triggered movements the nature of the executed response has a prominent effect on the intensity and the dynamics of motor areas recruitment. Under time pressure, the time course of motor areas recruitment is necessarily shorter than that of spontaneously triggered movements because RTs may be extremely short. Moreover, different classes of RT tasks allow examining the nature and the dynamics of motor areas activation in different cognitive contexts. In the present article, we review experimental results obtained from high temporal resolution methods (mainly, but not exclusively EEG ones), during voluntary movements; these results indicate that the activity of motor areas not only depends on the nature of the executed movement but also on the cognitive context in which these movements have to be executed.
A Formal Treatment of Accountable Proxying Over TLS

Much of Internet traffic nowadays passes through active proxies, whose role is to inspect, filter, cache, or transform data exchanged between two endpoints. To perform their tasks, such proxies modify channel-securing protocols, like TLS, resulting in serious vulnerabilities. Such problems are exacerbated by the fact that middleboxes are often invisible to one or both endpoints, leading to a lack of accountability. A recent protocol, called mcTLS, pioneered accountability for proxies, which are authorized by the endpoints and given limited read/write permissions to application traffic. Unfortunately, we show that mcTLS is insecure: the protocol modifies the TLS protocol, exposing it to a new class of middlebox-confusion attacks. Such attacks went unnoticed mainly because mcTLS lacked a formal analysis and security proofs. Hence, our second contribution is to formalize the goal of accountable proxying over secure channels. Third, we propose a provably-secure alternative to soon-to-be-standardized mcTLS: a generic and modular protocol-design that care- fully composes generic secure channel-establishment protocols, which we prove secure. Finally, we present a proof-of-concept implementation of our design, instantiated with unmodified TLS 1.3, and evaluate its overheads.
Accuracy of Real-time Intratracheal Bedside Ultrasonography and Waveform Capnography for Confirmation of Intubation in Multiple Trauma Patients

Background: A secure airway and effective ventilation are key components of advanced life support, and misplacement of endotracheal tube (ETT) can lead to morbidity in multiple trauma patients. The purpose of this study was to investigate the accuracy of ultrasound in diagnosis of direction for tracheal intubation. Materials and Methods: This descriptive-analytical study was conducted on 100 traumatic patients requiring intubation in 2016 in the Emergency Department of Al-Zahra and Kashani Medical Education Centers in Isfahan. Surface probe was placed transversally in the front of the neck at the top of the suprasternal notch, and the position of trachea was specified by front of comet-tail artifact which is the contour between hyperechoic air–mucosa (A–M) and a posterior reverberation artifact. Intubation accuracy by capnography was investigated, and the results were recorded in each patient's profile. Tracheal sonography was done during placement, or as soon as, the ETT has been embedded. The scanning time was minimized and it was carried out in total time of 10 s. Results: The diagnosis of intubation accuracy indicated that it was successful in 94 individuals (94%) and unsuccessful in 6 ones (6%). Intubation accuracy in 93 people (93%) was confirmed, and inaccuracy of intubation in 7 people (7%) was diagnosed. Ultrasound sensitivity in diagnosis of intubation accuracy was 97.9% (92.94) with 83.3% (5.6%) specificity. The positive and negative predictive values were 98.9% (92.93) and 71.4% (5.7%) respectively. Conclusion: Ultrasound method has high sensitivity and specificity to determine the correct placement of the tracheal tube, and it can be implemented as a reliable method given the acceptable positive and negative predictive values.
Quality assessment of systematic reviews of vitamin D, cognition and dementia

Background There is conflicting evidence regarding the association of vitamin D with cognition performance and dementia. Aims We aimed to summarise the evidence on the association of vitamin D with cognitive performance, dementia and Alzheimer disease through a qualitative assessment of available systematic reviews and meta-analyses. Method We conducted an overview of the systematic reviews of all study types with or without meta-analyses on vitamin D and either Alzheimer disease, dementia or cognitive performance up to June 2017. Results Eleven systematic reviews were identified, nine of which were meta-analyses with substantial heterogeneity, differing statistical methods, variable methodological quality and quality of data abstraction. A Measurement Tool to Assess Systematic Reviews checklist scores ranged from 4 to 10 out of 11, with seven reviews of ‘moderate’ and four of ‘high’ methodological quality. Out of six meta-analyses on the association between low serum concentration of 25-hydroxyvitamin D and risk of dementia, five showed a positive association. Results of meta-analyses on the association between low serum concentration of 25-hydroxyvitamin D and memory function tests showed conflicting results. Conclusions This systematic evaluation of available systematic reviews provided a clearer understanding of the potential link between low serum vitamin D concentrations and dementia. This evaluation also showed that the quality of the available evidence is not optimal because of both the low methodological quality of the reviews and low quality of the original studies. Interpretation of these systematic reviews should therefore be made with care. Declaration of interest None.
The transcription factor Lef1 switches partners from β-catenin to Smad3 during muscle stem cell quiescence

The transcription factor Lef1 switches partners as muscle stem cells transition from proliferation to quiescence. Muscle stem cells swap coactivators After birth, skeletal muscle stem cells (MuSCs) transition from a proliferative to a quiescent state. These quiescent stem cells, also known as satellite cells, retain the ability to self-renew and, upon activation, re-enter the cell cycle to generate myoblasts for muscle repair. The entry of MuSCs into quiescence is characterized by the expression of target genes that are activated by the Tcf and Lef (Tcf/Lef) family of transcription factors. Aloysius et al. found that, although Tcf/Lef transcription factors promoted gene expression by cooperating with β-catenin in response to Wnt signaling in proliferating myoblasts, β-catenin was not required for the induction of Tcf/Lef target genes during quiescence. Instead, Lef1 partnered with the transcriptional coactivator Smad3. Smad3 mediates transcriptional responses to transforming growth factor–β (TGF-β) signaling, implicating cross-talk between the Wnt and TGF-β pathways in controlling MuSC quiescence. Skeletal muscle stem cells (MuSCs), also known as satellite cells, persist in adult mammals by entering a state of quiescence (G0) during the early postnatal period. Quiescence is reversed during damage-induced regeneration and re-established after regeneration. Entry of cultured myoblasts into G0 is associated with a specific, reversible induction of Wnt target genes, thus implicating members of the Tcf and Lef1 (Tcf/Lef) transcription factor family, which mediate transcriptional responses to Wnt signaling, in the initiation of quiescence. We found that the canonical Wnt effector β-catenin, which cooperates with Tcf/Lef, was dispensable for myoblasts to enter quiescence. Using pharmacological and genetic approaches in cultured C2C12 myoblasts and in MuSCs, we demonstrated that Tcf/Lef activity during quiescence depended not on β-catenin but on the transforming growth factor–β (TGF-β) effector and transcriptional coactivator Smad3, which colocalized with Lef1 at canonical Wnt-responsive elements and directly interacted with Lef1 specifically in G0. Depletion of Smad3, but not β-catenin, reduced Lef1 occupancy at target promoters, Tcf/Lef target gene expression, and self-renewal of myoblasts. In vivo, MuSCs underwent a switch from β-catenin–Lef1 to Smad3-Lef1 interactions during the postnatal switch from proliferation to quiescence, with β-catenin–Lef1 interactions recurring during damage-induced reactivation. Our findings suggest that the interplay of Wnt-Tcf/Lef and TGF-β–Smad3 signaling activates canonical Wnt target promoters in a manner that depends on β-catenin during myoblast proliferation but is independent of β-catenin during MuSC quiescence.
Checklist of gypsophilous vascular flora in Italy

Abstract Our understanding of the richness and uniqueness of the flora growing on gypsum substrates in Italy has grown significantly since the 19th century and, even today, new plant species are still being discovered. However, the plants and plant communities, growing on gypsum substrates in Italy, are still a relatively unknown subject. The main aim of this paper was to elaborate a checklist of the Italian gypsophilous flora, to increase knowledge about this peculiar flora and for which conservation efforts need to be addressed. Through a structured group communication process of experts (application of the Delphi technique), a remarkable number of experienced Italian botanists have joined together to select focal plant species linked to gypsum substrates. From the results obtained, 31 plant species behave as absolute or preferent taxa (gypsophytes and gypsoclines) and form the ‘core’ Italian gypsophilous flora. The most abundant life forms were chamaephytes and hemicryptophytes, belonging to Poaceae and Brassicaceae; as for chorotypes, the most represented are Mediterranean and narrow endemics. By improving on previously available information about the flora with a clear preference for gypsum in Italy, this undertaking represents an important contribution to the knowledge of a habitat which is today considered a priority for conservation.
A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models

Aim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.
Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi

Immune correlates of protection against intracellular bacterial pathogens are largely thought to be cell-mediated, although a reasonable amount of data supports a role for antibody-mediated protection. To define a role for antibody-mediated immunity against an intracellular pathogen, Rhodococcus equi, that causes granulomatous pneumonia in horse foals, we devised and tested an experimental system relying solely on antibody-mediated protection against this host-specific etiologic agent. Immunity was induced by vaccinating pregnant mares 6 and 3 weeks prior to predicted parturition with a conjugate vaccine targeting the highly conserved microbial surface polysaccharide, poly-N-acetyl glucosamine (PNAG). We ascertained antibody was transferred to foals via colostrum, the only means for foals to acquire maternal antibody. Horses lack transplacental antibody transfer. Next, a randomized, controlled, blinded challenge was conducted by inoculating at ~4 weeks of age ~106 cfu of R. equi via intrabronchial challenge. Eleven of 12 (91%) foals born to immune mares did not develop clinical R. equi pneumonia, whereas 6 of 7 (86%) foals born to unvaccinated controls developed pneumonia (P = 0.0017). In a confirmatory passive immunization study, infusion of PNAG-hyperimmune plasma protected 100% of 5 foals against R. equi pneumonia whereas all 4 recipients of normal horse plasma developed clinical disease (P = 0.0079). Antibodies to PNAG mediated killing of extracellular and intracellular R. equi and other intracellular pathogens. Killing of intracellular organisms depended on antibody recognition of surface expression of PNAG on infected cells, along with complement deposition and PMN-assisted lysis of infected macrophages. Peripheral blood mononuclear cells from immune and protected foals released higher levels of interferon-γ in response to PNAG compared to controls, indicating vaccination also induced an antibody-dependent cellular release of this critical immune cytokine. Overall, antibody-mediated opsonic killing and interferon-γ release in response to PNAG may protect against diseases caused by intracellular bacterial pathogens.
Architectural Impacts of RFiop: RF to Address I/O Pad and Memory Controller Scalability

Despite power boundaries, Moore’s law is still present via scaling the number of cores, which keeps adding demands for more memory bandwidth (MBW) requested by these cores. To obtain higher MBW levels, it is fundamental to address memory controller (MC) scalability. However, MC scalability growth is limited by I/O pin counts scaling. To underline MC and pin scaling, a radio frequency(<underline>RF</underline>) <underline>I</underline>/<underline>O</underline> pad-scalable <underline>p</underline>ackage-based (RFiop) memory organization is further investigated. In RFiop, a RF pad (RFpad) is defined as a quilt-packaging (QP) coplanar waveguide employed at RF ranges. An RFpad connects a rank to an RFMC which is formed by coupling MCs to RF transmitter/receivers. By using QP package to explore the architectural benefits of laying out ranks, RFiop replaces the traditional memory path with an RF-based one, while exploring the scalability of RFpads/RFMCs via RF signaling. When evaluating RFiop, our findings show that MBW/performance are enhanced by around <inline-formula> <tex-math notation="LaTeX">$4.3\times $ </tex-math></inline-formula> which can be viewed as a diminution in transaction queue occupancy/latency as well as using a reduced and scalable 4–8 RFpads per RFMC. RFiop architectural area benefits allow MBW/performance improvements of around <inline-formula> <tex-math notation="LaTeX">$3.2\times $ </tex-math></inline-formula>, while reducing interconnection energy up to 78%.