Miracle-dz/UniFAR-FTUs huggingface dataset:
Nuclear energy economics: An update to fact finding nuclear energy

In 2007, the ECN report Fact Finding Nuclear Energy was commissioned by the Social Economic Council of the Netherlands (SER) to answer the question whether more nuclear energy should be generated to support the objective of realizing a cost effective CO2 neutral energy system in the Netherlands. In the study, facts and data on nuclear energy were collected on the basis of existing insights and literature. The present report has been written to update the economics aspects of nuclear energy of the Fact Finding Nuclear Energy 2007 report of ECN using recent data. Non-economic aspects are not considered.
Erasmus Students’ Mobility Priorities: A Rank-Order Scaling Study

higher education and is still among the most visible. Bologna process has played a prominent role in promoting mobility by establishing more compatible course patterns and encouraging greater transparency. Student mobility involved 213,266 people distributed among the twentyseven states of the European Union, Iceland, Liechtenstein, Norway, Switzerland, Croatia, and Turkey. The purpose of this study is to identify the preferences studying abroad and present the priorities of incoming and outgoing Erasmus students’ university preference among the ranked items. According to the rank ordering scaling findings; incoming students prioritized the university related factors while outgoing students prioritized the factors related social environment.
Effects of Steroid Hormone Interaction on Activity and Home-Range Size of Male Lizards

Steroid hormones play a major role in influencing the physiology and behavior of all animals, including reptiles. Oftentimes, it is an interaction between two or more hormones that is ultimately responsible for the observed response or behavior. We designed a pair of field studies on adjacent communities of side-blotched lizards (Uta stansburiana) to provide insight into the interrelationship of testosterone (T) and corticosterone (B) in regulating aggressive behavior. On one site, males were implanted with either T or saline (S), while on the other site males received either two S implants or both a T and a B implant (T + B). T increased both activity (by 31%) and home-range size (by 150%), whereas S-implanted cohorts exhibited a reduction in both of these parameters (by 24 and 50%, respectively). However, when B was given in combination with T, not only were the positive effects of T eliminated, but there was a reduction in activity (31%) and home-range size (72%) similar to that reported in lizards that received B implants alone. S-implanted cohorts in the T + B experiment increased their activity and home-range size by 15 and 43%, respectively. Although these latter changes in the S-implanted males are not statistically significant, they are indicative of a compensatory increase similar to that seen in the T and previously reported B outcrop experiments. Taken together, these results illustrate that regulation of aggressive behavior is complicated, with both hormonal and social interactions playing critical roles in determining an individual's home-range size and, hence, reproductive success.
Trait Versus Situation-Specific Intolerance of Uncertainty in a Clinical Sample with Anxiety and Depressive Disorders

Intolerance of uncertainty (IU) has been most heavily implicated in the development and maintenance of generalised anxiety disorder; however, recent research has supported the transdiagnostic conceptualisation of IU by demonstrating that IU contributes to a broad array of symptoms associated with multiple anxiety and depressive disorders. The aim of this study was to examine IU firstly as a trait variable and secondly in reference to a regularly occurring, diagnostically relevant situation in a large clinical sample (N = 218). A measure of situation-specific IU (the Intolerance of Uncertainty Scale–Situation-Specific Version; IUS-SS) is presented. The IUS-SS was found to have a unitary factor structure and high internal consistency. Participants reported significantly more situation-specific IU compared to trait IU. Discriminant validity was indicated by lack of significant relationships with measures of extraversion and alcohol use. Supporting the convergent validity and transdiagnostic nature of the scale, the IUS-SS was positively associated with neuroticism and symptoms of generalised anxiety disorder and social phobia, and explained unique variance in symptoms of depression and panic disorder above and beyond trait IU. Theoretical and clinical implications are discussed.
Tumour‐infiltrating lymphocytes in non‐small cell lung cancer are activated T lymphocytes

This study was carried out in order to investigate the local immune reaction of tumour‐infiltrating lymphocytes (TILs) in the primary tumours of non‐small cell lung carcinomas. Thirty non‐small cell lung cancer (NSCLC) patients were included. The tumour tissue was taken at thoracotomy and monocellular suspension of the tumour was obtained by mechanical disaggregation. Dual‐coloured flow cytometric analysis of TILs and their corresponding peripheral blood lymphocytes (PBLs) was performed. Tumour‐infiltrating lymphocytes contained significantly higher proportions of CD3(+) T lymphocytes and CD8(+) T lymphocytes than the corresponding PBLs (82.0%±13.9%vs 66.3%±10.6% for CD3, P<0.001; 39.0%±18.4%vs 26.4%±5.2% for CD8, P<0.001). Tumour‐infiltrating lymphocytes contained significantly higher proportions of activated memory lymphocytes than PBLs did (9.8%±8.6%vs 1.3%±1.5% for CD25, P<0.001; 40.5%±30.2%vs 10.2%±14.8% for CD71, P<0.001; 75.5%±11.9%vs 28.6%±9.8% for HLA‐DR, P<0.001). These findings were also found in both CD4(+) TILs and CD8(+) TILs. The TILs of NSCLC contained higher proportions of T lymphocytes and CD8(+) lymphocytes than their corresponding peripheral bloods. The proportions of activated memory lymphocytes were also significantly higher in the TILs, both in CD4(+) TILs and CD8(+) TILs, than the corresponding PBLs.
Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up.

OBJECTIVE While guidelines for treating patients with bipolar depression recommend discontinuing antidepressants within 6 months after remission, few studies have assessed the implications of this strategy on the risk for depressive relapse. This study examined the effect of antidepressant discontinuation or continuation on depressive relapse risk among bipolar subjects successfully treated for an acute depressive episode. METHOD Eighty-four subjects with bipolar disorder who achieved remission from a depressive episode with the addition of an antidepressant to an ongoing mood stabilizer regimen were followed prospectively for 1 year. The risk of depressive relapse among 43 subjects who stopped antidepressant treatment within 6 months after remission ("discontinuation group") was compared with the risk among 41 subjects who continued taking antidepressants beyond 6 months ("continuation group"). RESULTS A Cox proportional hazards regression analysis indicated that shorter antidepressant exposure time following successful treatment was associated with a significantly shorter time to depressive relapse. Furthermore, patients who discontinued antidepressant treatment within the first 6 months after remission experienced a significantly shorter period of euthymia before depressive relapse over the length of 1-year follow-up. One year after successful antidepressant response, 70% of the antidepressant discontinuation group experienced a depressive relapse compared with 36% of the continuation group. By the 1-year follow-up evaluation, 15 (18%) of the 84 subjects had experienced a manic relapse; only six of these subjects were taking an antidepressant at the time of manic relapse. CONCLUSIONS The risk of depressive relapse in patients with bipolar illness was significantly associated with discontinuing antidepressants soon after remission. The risk of manic relapse was not significantly associated with continuing use of antidepressant medication and, overall, was substantially less than the risk of depressive relapse. Maintenance of antidepressant treatment in combination with a mood stabilizer may be warranted in some patients with bipolar disorder.
Social and coping reasons for drinking: predicting alcohol misuse in adolescents.

OBJECTIVE Motivational models of alcohol consumption suggest a positive relationship between reasons for drinking and the amount of alcohol consumed. The present study examined race, gender, and age as moderators of the relationship between social and coping motives and alcohol misuse in black and white adolescents. METHOD A representative population sample (N = 699) of male and female (54%) adolescents between the ages of 13 and 16 was recruited using a random-digit-dial telephone procedure. Six face-to-face interviews with subjects and their families were carried out at approximately yearly intervals. Information gathered assessed alcohol use, social and coping motives for drinking, and psychological distress. RESULTS Multiple analyses, including both cross-sectional and longitudinal logistic regression analyses and survival analysis were used to examine the relationship of drinking motives to adolescent alcohol misuse. Contrary to our predictions, social motive was a somewhat better predictor of alcohol misuse than was coping motive, particularly during mid- to late adolescence. However, there was some limited evidence of a significant relationship between coping motives and alcohol misuse in the mid-adolescent age group. Some support was found for racial differences such that social motives are better predictors of alcohol misuse among whites than among blacks and coping motives are better predictors among blacks. Few gender differences were found in the relationship of drinking motives and alcohol misuse. CONCLUSIONS These findings suggest a stronger tendency for social and coping motives to influence alcohol misuse during mid to late than in early adolescence. Research examining the development of motives and the mechanisms by which they influence drinking behavior is needed.
Mortality patterns in partially edentulous and edentulous elderly patients treated with dental implants.

UNLABELLED An association between oral health, number of teeth, and mortality has been reported in the literature, but limited knowledge is available on mortality in elderly partially edentulous and edentulous patients treated with implants. PURPOSE The aim of this retrospective study was to compare the mortality pattern in elderly patients (80 years or older) who were provided with implants and were partially or completely edentulous. MATERIALS AND METHODS Between 1986 and 2003, a total of 266 elderly patients with a mean age of 83.0 years at the time of implant placement were included. The patients were provided with 1,384 Brånemark System implants (Nobel Biocare) in 285 arches. The sample was divided into two subgroups: 108 edentulous patients and 158 partially edentulous patients. Information was collected for each individual regarding expected remaining lifetime at the time of implant surgery. Cumulative survival rate (CSR) was calculated and compared for the two subgroups covering 10 years and was also compared to expected CSR data for normal populations of comparable distribution. RESULTS Mortality was significantly decreased (P < .05) for partially edentulous compared with edentulous patients (-10.4%) after 10 years of follow-up. CSR for the elderly groups showed a significant decrease in mortality compared with comparable groups of normal populations (P < .05). There was no significant difference in morality between healthy/nonhealthy patients at first surgery or patients with reported/unreported implant failures (P > .05). CONCLUSIONS Elderly partially edentulous patients had significantly lower mortality compared with edentulous patients over a 10-year period of follow-up. Both subgroups also showed significantly lower mortality compared with normal populations of comparable sex and age at the time of implant surgery. The observation is interpreted as that these patients are healthier and more motivated to replace their lost teeth with implants than the normal population rather than that implant treatment per se reduces mortality.
Reducing Medical Admissions into Hospital through Optimising Medicines (REMAIN HOME) Study: protocol for a stepped-wedge, cluster-randomised trial

Introduction A model of general practitioner (GP) and pharmacist collaboration in primary care may be an effective strategy to reduce medication-related problems and provide better support to patients after discharge. The aim of this study is to investigate whether a model of structured pharmacist and GP care reduces hospital readmissions in high-risk patients. Methods and analysis This protocol details a stepped-wedge, cluster-randomised trial that will recruit participants over 9 months with a 12-month follow-up. There will be 14 clusters each representing a different general practice medical centre. A total of 2240 participants will be recruited from hospital who attend an enrolled medical centre, take five or more long-term medicines or whose reason for admission was related to heart failure or chronic obstructive pulmonary disease. The intervention is a multifaceted service, involving a pharmacist integrated into a medical centre to assist patients after hospitalisation. Participants will meet with the practice pharmacist and their GP after discharge to review and reconcile their medicines and discuss changes made in hospital. The pharmacist will follow-up with the participant and liaise with other health professionals involved in the participant’s care. The control will be usual care, which usually involves a patient self-organising a visit to their GP after hospital discharge. The primary outcome is the rate of unplanned, all-cause hospital readmissions over 12 months, which will be analysed using a mixed effects Poisson regression model with a random effect for cluster and a fixed effect to account for any temporal trend. A cost analysis will be undertaken to compare the healthcare costs associated with the intervention to those of usual care. Ethics and dissemination The study has received ethical approval (HREC/16/QRBW/410). The study findings will be disseminated through peer-reviewed publications, conferences and reports to key stakeholders. Trial registration number ACTRN12616001627448
Taiwan and U.S. Equity Market Interdependence and Contagion: Evidence from Four-Factor Model

A four-factor model is used to measure the interdependenceâ€™s co-movement and crisisâ€™ contagion effect on portfolio returns of 23 Taiwanese industries during tranquil and the U.S. subprime mortgage crisis periods. By incorporating the control variables of economic and financial fundamentals, we deconstruct the relevance of returns on industrial assetsâ€™ channels. The empirical results show that the co-movement effect on Taiwanâ€™s industrial portfolios returns are affected by global, regional, and domestic factors. Additionally, in the subprime mortgage crisis period, the contagion effect of Taiwanâ€™s industrial portfolios returns was affected by the domestic and crisis factor. Based on our empirical study, the transmission of Taiwanâ€™s industrial portfolio returns channel is significantly impacted by the instrument variables of interest rate, trade integration, political stability, and government budgets of the economy fundamentals
Clinical, phenotypic and genetic similarities and disparities between post-transplant and classical Hodgkin lymphomas with respect to therapeutic targets

Objective: Post-transplant Hodgkin lymphoma (ptHL) is a rare but serious complication. We explored the clinical, phenotypic and genetic similarities and disparities between ptHL and classical Hodgkin lymphoma (cHL) in immunocompetent patients and sought proteins/pathways in ptHL that might have potential as therapeutic targets. Research design and methods: Eight ptHL cases in solid organ recipients (mean patient age 36 years; mean duration between organ transplant and onset of ptHL 80 months) were phenotypically and genotypically analyzed and the results were compared with known phenotypic and molecular characteristics of cHL. Results: All ptHL expressed CD15, CD30 and LMP-1 of EBV; the B-cell markers BOB-1, Oct2, CD79a and CD20 were more commonly expressed in ptHL versus cHL (100%, 86%, 50% and 38% in ptHL compared to 6%, 14%, 10% and 33% in cHL, respectively); all ptHL expressed phosphoinositide 3-kinase (PI3K) versus 81% of cHL; 2/6 (33%) ptHL displayed gains at 9p24 that were similar to cHL (32%). The JAK2 downstream pSTAT3 slightly predominated in ptHL versus cHL (60% versus 50%). Clonal immunoglobulin gene rearrangements were found in 2/4 cases. Conclusions: ptHL and cHL are closely related, but not identical, neoplasms, with the primary differences being the strict association with EBV infection, persistent phenotypic B-cell signature and high expression of PI3K as well as the slightly CD4-depleted but TIA-1/Granzyme B-enriched cellular background composition in ptHL.
Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study.

PURPOSE To prospectively determine cancer yield, callback and biopsy rates, and positive predictive value (PPV) of mammography, magnetic resonance (MR) imaging, and ultrasonography (US) in women at high risk for breast cancer. MATERIALS AND METHODS The study was approved by the institutional review board and was HIPAA compliant, and informed consent was obtained. We conducted a prospective pilot study of screening mammography, MR, and US in asymptomatic women 25 years of age or older who were genetically at high risk, defined as BRCA1/BRCA2 carriers or with at least a 20% probability of carrying a BRCA1/BRCA2 mutation. All imaging modalities were performed within 90 days of each other. Data were analyzed by using exact confidence intervals (CIs) and the McNemar test. RESULTS A total of 195 women were enrolled in this study over a 6-month period, and 171 completed all study examinations (mammography, US, and MR). Average age of the 171 participants was 46 years +/- 10.2 (standard deviation). Sixteen biopsies were performed and six cancers were detected, for an overall 3.5% cancer yield. MR enabled detection of all six cancers; mammography, two; and US, one. The diagnostic yields for each test were 3.5% for MR, 0.6% for US, and 1.2% for mammography. MR, US, and mammography findings prompted biopsy in 8.2%, 2.3%, and 2.3% of patients, respectively. None of the pairwise comparisons were statistically significant. The PPV of biopsies performed as a result of MR was 43%. CONCLUSION Screening MR imaging had a higher biopsy rate but helped detect more cancers than either mammography or US. US had the highest false-negative rate compared with mammography and MR, enabling detection of only one in six cancers in high-risk women.
Exploring the Impact of Financial Development on Inequality: Evidence from Three Asian Countries

The broad objective of the present study is to investigate the impact of financial development along with some other variables namely GDP per capita, inﬂation rate, human capital, and trade openness for three developing Asian countries- Bangladesh, India and Pakistan. Annual time series data during the period 1980-2014 have been used for empirical investigation. After employing appropriate tests and estimation techniques, it is found that the financial development is statistically insignificant for all three countries, it implies that yet these developing countries are not efficiently allocating domestic private credit to poor segments of population. The results also reveal that inflation impedes income inequality for Bangladesh and India. GDP growth rate is insignificant for India and Pakistan however it is significant for Bangladesh having statistically positive relationship with income inequality. It means that GDP growth rate is linked with growth of income of elite class rather than bottom segments of population. National income improves inequality for Bangladesh but have insignificant affect on income inequality for India and Pakistan. Similarly, trade openness is insignificant for India and Pakistan, however it is significant for Bangladesh having statistically positive relationship with income inequality, which indicates that there is increasing unemployment in these countries due to lesser employment opportunities for skilled and unskilled labour. Empirical results of human capital shows insignificancy for India and Pakistan where as it is significant for Bangladesh; hence revealing that these countries failed to optimally utilize their resources in educational sector.
Prognostic importance of T and NK‐cells in a consecutive series of newly diagnosed patients with chronic lymphocytic leukaemia

Patients with chronic lymphocytic leukaemia (CLL) have a variable clinical course. The identification of modifiable characteristics related to CLL‐specific survival may provide opportunities for therapeutic intervention. The absolute number of T‐cell and natural killer (NK)‐cells was calculated for 166 consecutive patients with CLL evaluated by flow cytometry at Mayo Clinic ≤2 months of diagnosis. The size of the T‐cell/NK‐cell compartment relative to the size of the malignant monoclonal B‐cell (MBC) compartment was evaluated by calculating NK:MBC and T:MBC ratios. Patients exhibited substantial variation in the absolute number of T‐ and NK‐cells as well as T:MBC and NK:MBC ratios at diagnosis. Higher T:MBC and NK:MBC ratios were observed among patients with early stage and mutated IGHV genes (all P ≤ 0·0003). As continuous variables, both T:MBC ratio (P‐value = 0·03) and NK:MBC ratio (P‐value = 0·02) were associated with time to treatment (TTT). On multivariate Cox modelling including stage, CD38, absolute MBC count, NK:MBC ratio and T:MBC ratio, the independent predictors of TTT were stage, T:MBC ratio and NK:MBC ratio. These findings suggest that measurable characteristics of the host immune system relate to the rate of disease progression in patients with newly diagnosed CLL. These characteristics can be modified and continued evaluation of immunomodulatory drugs, vaccination strategies and cellular therapies to delay/prevent disease progression are warranted.
Performance evaluation of seven machine learning classification techniques for movie box office success prediction

Movie industry is a multi-billion-dollar industry and now there is a huge amount of data available on the internet related to movie industry. Researchers have developed different machine learning methods which can make good classification models. In this paper, various machine learning classification methods are implemented on our own movie dataset for multi class classification. The main goal of this paper is to conduct performance comparison among various machine learning methods. We choose seven machine learning techniques for this comparison such as Support Vector Machine (SVM), Logistic Regression, Multilayer Perceptron Neural Network, Gaussian Naive Bayes, Random Forest, AdaBoost and Stochastic Gradient Descent (SGD). All of these methods predict an approximate net profit value of a movie by analyzing historical data from different sources like IMDb, Rotten Tomatoes, Box Office Mojo and Meta Critic. For all these seven methods, the system predicts a movie box office profit based on some pre-released features and post-released features. This paper analyzes the performance assessment of all these seven machine learning techniques based on our own dataset which contains 755 movies. Among these seven algorithms, Multilayer perceptron Neural Network gives better result.