Miracle-dz/UniFAR-FTUs huggingface dataset:
Short-Term Beat-to-Beat QT Variability Appears Influenced More Strongly by Recording Quality Than by Beat-to-Beat RR Variability

Increases in beat-to-beat variability of electrocardiographic QT interval duration have repeatedly been associated with increased risk of cardiovascular events and complications. The measurements of QT variability are frequently normalized for the underlying RR interval variability. Such normalization supports the concept of the so-called immediate RR effect which relates each QT interval to the preceding RR interval. The validity of this concept was investigated in the present study together with the analysis of the influence of electrocardiographic morphological stability on QT variability measurements. The analyses involved QT and RR measurements in 6,114,562 individual beats of 642,708 separate 10-s ECG samples recorded in 523 healthy volunteers (259 females). Only beats with high morphology correlation (r > 0.99) with representative waveforms of the 10-s ECG samples were analyzed, assuring that only good quality recordings were included. In addition to these high correlations, SDs of the ECG signal difference between representative waveforms and individual beats expressed morphological instability and ECG noise. In the intra-subject analyses of both individual beats and of 10-s averages, QT interval variability was substantially more strongly related to the ECG noise than to the underlying RR variability. In approximately one-third of the analyzed ECG beats, the prolongation or shortening of the preceding RR interval was followed by the opposite change of the QT interval. In linear regression analyses, underlying RR variability within each 10-s ECG sample explained only 5.7 and 11.1% of QT interval variability in females and males, respectively. On the contrary, the underlying ECG noise contents of the 10-s samples explained 56.5 and 60.1% of the QT interval variability in females and males, respectively. The study concludes that the concept of stable and uniform immediate RR interval effect on the duration of subsequent QT interval duration is highly questionable. Even if only stable beat-to-beat measurements of QT interval are used, the QT interval variability is still substantially influenced by morphological variability and noise pollution of the source ECG recordings. Even when good quality recordings are used, noise contents of the electrocardiograms should be objectively examined in future studies of QT interval variability.
The Impact of Posttraumatic Stress Disorder on Dysfunctional Implicit and Explicit Emotions Among Women With Borderline Personality Disorder

A comorbid posttraumatic stress disorder (PTSD) aggravates symptoms, course of illness and social functioning of persons with borderline personality disorder (BPD). However, it is largely unclear how this effect is mediated. In 60 women with BPD of whom 23 had a comorbid current PTSD we investigated whether dysfunctional explicit and implicit emotions were associated with a comorbid PTSD. Shame and guilt proneness, anxiety, anger–hostility, and general psychopathology were assessed by self-report measures. Implicit anxiety-related self-concept was measured using the Implicit Association Test. Self-reported guilt proneness and general psychopathology, but not shame proneness or trait anxiety, were significantly higher in women with BPD and PTSD than in women with BPD alone. A comorbid PTSD was associated with a more anxiety-prone (relative to shame-prone) implicit self-concept as assessed by the Implicit Association Test. Self-reported guilt proneness and implicit anxiety may mediate the negative impact of comorbid PTSD on women with BPD.
Have we put an end to social promotion? Changes in school progress among children aged 6 to 17 from 1972 to 2005

We examine trends over time in the proportion of children below the modal grade for their age (BMG), a proxy for grade retention, and in the effects of its demographic and socioeconomic correlates. We estimate a logistic regression model with partial constraints predicting BMG using the annual October school enrollment supplements of the Current Population Survey. This model identifies systematic variation in the effects of social background across age and time from 1972 to 2005. While the effects of socioeconomic background variables on progress through school have become increasingly powerful as children grow older, that typical pattern has been attenuated across the past three decades by a steady secular decline in the influence of those variables across all ages. A great deal of concern has been expressed about rising levels of economic and social inequality in the United States since the middle 1970s, and about the potential intergenerational effects of such inequality. However, there has been an opposite trend in the effects of social origins on being BMG. A trend is not a law, and there is reason to be concerned about the recent deceleration of the secular decline in effects of social background on being BMG.
Synergistic Attraction of Aedes aegypti (L.) to Binary Blends of L-Lactic Acid and Acetone, Dichloromethane, or Dimethyl Disulfide

Abstract Kairomones produced by humans provide female anthropophilic mosquitoes with vital cues used in host-seeking for a blood meal. These chemicals are emanated primarily by the skin and provide the mosquitoes a means to orient themselves to humans at a relatively close range. Chemical studies of these emanations have provided new ideas for the formulation of attractant blends. We report mosquito attraction responses for three binary blends and their separate components. The blends are comprised of L-lactic acid plus either acetone, dichloromethane, or dimethyl disulfide. At the emission rates used in our bioassays, these blends synergistically attract laboratory-reared female Aedes aegypti. Carbon dioxide is not a necessary component to yield high levels of attraction with these blends. It is postulated that at least one of these synergistic blends (L-lactic acid and acetone) produces mosquito attraction behavior similar to L-lactic acid and CO2.
Hydrometeorology of Heavy Rainstorms in Chicago and Northeastern Illinois, Phase I—Historical Studies

This report presents the results of an investigation of the distribution of heavy rainstorms in the Chicago urban area and the surrounding six counties, based on available historical rain data (primarily 1949-1974). The six counties are Cook, Du Page, Kane, Will, Lake, and McHenry. Presented are frequency distributions of point rainfall for rain periods from 5 minutes to 72 hours and recurrence intervals of 6 months to 50 years. Also presented are point-area relationships, frequency distribution of storm centers, diurnal and seasonal distribution of heavy storms, orientation of heavy storms, storm shapes, synoptic weather conditions associated with severe rainstorms, time between heavy rain occurrences, and time distribution characteristics of rainfall during heavy storms. Results are pertinent to design of hydraulic structures such as storm sewers. This historical study is the first phase of a comprehensive hydrometeorological research program for northeastern Illinois that will include, as the next phase, an extensive field measurement project in the area. Reference: Huff, Floyd A. , and John L. Vogel. Hydrometeorology of Heavy Rainstorms in Chicago and Northeastern Illinois, Phase I — Historical Studies. Illinois State Water Survey, Urbana, Report of Investigation 82, 1976. Indexing Terms: Climatology, heavy rainstorms, hydrometeorology, local precipitation, rainfall frequency distributions, rainfall intensity, storm characteristics, urban weather. STATE OF ILLINOIS HON. DANIEL WALKER, Governor DEPARTMENT OF REGISTRATION AND EDUCATION RONALD E. STACKLER, J.D. , Director BOARD OF NATURAL RESOURCES AND CONSERVATION Ronald E. Stackler, J.D. , Chairman Thomas Park, Ph.D., Biology H. S. Gutowsky, Ph.D., Chemistry Robert H. Anderson, B.S., Engineering Stanley K. Shapiro, Ph.D., Forestry Laurence L. Sloss, Ph.D., Geology John C. Guyon, Ph.D., Southern Illinois University William L. Everitt, E.E. ,Ph.D., University of Illinois STATE WATER SURVEY DIVISION WILLIAM C. ACKERMANN, D.Sc, Chief
Functional Replacement of the Carboxy-Terminal Two-Thirds of the Influenza A Virus NS1 Protein with Short Heterologous Dimerization Domains

ABSTRACT The NS1 protein of influenza A/WSN/33 virus is a 230-amino-acid-long protein which functions as an interferon alpha/beta (IFN-α/β) antagonist by preventing the synthesis of IFN during viral infection. In tissue culture, the IFN inhibitory function of the NS1 protein has been mapped to the RNA binding domain, the first 73 amino acids. Nevertheless, influenza viruses expressing carboxy-terminally truncated NS1 proteins are attenuated in mice. Dimerization of the NS1 protein has previously been shown to be essential for its RNA binding activity. We have explored the ability of heterologous dimerization domains to functionally substitute in vivo for the carboxy-terminal domains of the NS1 protein. Recombinant influenza viruses were generated that expressed truncated NS1 proteins of 126 amino acids, fused to 28 or 24 amino acids derived from the dimerization domains of either the Saccharomyces cerevisiae PUT3 or the Drosophila melanogaster Ncd (DmNcd) proteins. These viruses regained virulence and lethality in mice. Moreover, a recombinant influenza virus expressing only the first 73 amino acids of the NS1 protein was able to replicate in mice lacking three IFN-regulated antiviral enzymes, PKR, RNaseL, and Mx, but not in wild-type (Mx-deficient) mice, suggesting that the attenuation was mainly due to an inability to inhibit the IFN system. Remarkably, a virus with an NS1 truncated at amino acid 73 but fused to the dimerization domain of DmNcd replicated and was also highly pathogenic in wild-type mice. These results suggest that the main biological function of the carboxy-terminal region of the NS1 protein of influenza A virus is the enhancement of its IFN antagonist properties by stabilizing the NS1 dimeric structure.
Enalapril Decreases Prevalence of Ventricular Tachycardia in Patients With Chronic Congestive Heart Failure

BackgroundPatients with heart failure have a high prevalence of serious arrhythmias and sudden cardiac death. Methods and ResultsMale patients aged 18-75 years with chronic heart failure were randomized to enalapril or hydralazine-isosorbide dinitrate. Short-term (4-hour to 8-hour) Holter tape recordings were performed before randomization, at 3 months, at 1 year, and yearly thereafter. Of 804 patients randomized to therapy, 715 had Holters at baseline. Couplets were noted in 56% versus 60 % and ventricular tachycardia (VT) (three or more consecutive ventricular premature beats) in 27% versus 29% of patients randomized to enalapril versus hydralazine-isosorbide dinitrate, respectively. The presence of VT at 3 months, 1 year, and 2 years predicted significantly higher mortality during the subsequent year (P<0.0001,P<0.001, and P<0.037, respectively). In the enalapril group, VT prevalence decreased by 27% at 1 year (P<0.02). A decrease in prevalence of VT was not seen in the hydralazine-isosorbide dinitrate group. New VT was seen in 11% of enalapril patients versus 24% of hydralazine-isosorbide dinitrate patients at 1 year (P<0.002). When compared with hydralazine-isosorbide dinitrate at 1 and 2 years, there was a 52% and 49% 1 reduction, respectively, in sudden deaths in the enalapril group. Thus, at 1 and 2 years, the decrease in sudden deaths in the enalapril group coincided with the decrease in VT prevalence and the decrease in new VT emergence. ConclusionsIn patients with heart failure, VT and couplets predict increased mortality. When compared with hydralazine-isosorbide dinitrate, enalapril decreases both the persistence of baseline VT at 3 months and the emergence of new VT at 1 and 2 years. The reduction in VT prevalence parallels a reduction in sudden death. The effect of enalapril on survival over hydralazine-isosorbide dinitrate may be related to its ability to reduce prevalence of ventricular arrhythmia.
An interpolation problem for completely positive maps on matrix algebras: solvability and parametrization

We present certain existence criteria and parameterizations for an interpolation problem for completely positive maps that take given matrices from a finite set into prescribed matrices. Our approach uses density matrices associated to linear functionals on -subspaces of matrices, inspired by the Smith-Ward linear functional and Arveson’s Hahn-Banach Type Theorem. A necessary and sufficient condition for the existence of solutions and a parametrization of the set of all solutions of the interpolation problem in terms of a closed and convex set of an affine space are obtained. Other linear affine restrictions, like trace preserving, can be included as well, hence covering applications to quantum channels that yield certain quantum states at prescribed quantum states. We also perform a careful investigation on the intricate relation between the positivity of the density matrix and the positivity of the corresponding linear functional.
Prevalence and Risk Factors for Bloodborne Exposure and Infection in Correctional Healthcare Workers

Objective. To determine the prevalence and risk factors for bloodborne exposure and infection in correctional healthcare workers (CHCWs). Design. Cross-sectional risk assessment study with a confidential questionnaire and serological testing performed during 1999-2000. Setting. Correctional systems in 3 states. Results. Among 310 participating CHCWs, the rate of percutaneous injury (PI) was 32 Pis per 100 person-years overall and 42 Pis per 100 person-years for CHCWs with clinical job duties. Underreporting was common, with only 25 (49%) of 51 Pis formally reported to the administration. Independent risk factors for experiencing PI included being age 45 or older (adjusted odds ratio [aOR], 2.41 (95% confidence interval (CI), 1.31-4.46]) and having job duties that involved needle contact (aOR, 3.70 [95% CI, 1.28-10.63]) or blood contact (aOR, 5.05 [95% CI, 1.45-17.54]). Overall, 222 CHCWs (72%) reported having received a primary hepatitis В vaccination series; of these, 150 (68%) tested positive for anti-hepatitis B surface antigen, with negative results significantly associated with receipt of last dose more than 5 years previously. Serologic markers of hepatitis В virus infection were identified in 31 individuals (10%), and the prevalence of hepatitis B virus infection was 2% (n = 7). The high hepatitis B vaccination rate limited the ability to identify risk factors for infection, but hepatitis C virus infection correlated with community risk factors only. Conclusion. Although the wide coverage with hepatitis B vaccination and the decreasing rate of hepatitis C virus infection in the general population are encouraging, the high rate of exposure in CHCWs and the lack of exposure documentation are concerns. Continued efforts to develop interventions to reduce exposures and encourage reporting should be implemented and evaluated in correctional healthcare settings. These interventions should address infection control barriers unique to the correctional setting.
Neutrophil Serine Proteinases Activate Human Nonepithelial Cells to Produce Inflammatory Cytokines Through Protease-Activated Receptor 21

Protease-activated receptors (PARs) compose a family of G protein-coupled receptors activated by proteolysis with exposure of their tethered ligand. Recently, we reported that a neutrophil-derived serine proteinase, proteinase 3 (PR3), activated human oral epithelial cells through PAR-2. The present study examined whether other neutrophil serine proteinases, human leukocyte elastase (HLE), and cathepsin G (Cat G) activate nonepithelial cells, human gingival fibroblasts (HGF). HLE and Cat G as well as PR3 activated HGF to produce IL-8 and monocyte chemoattractant protein 1. Human oral epithelial cells but not HGF express mRNA and protein of secretory leukocyte protease inhibitor, an inhibitor of HLE and Cat G, and recombinant secretory leukocyte protease inhibitor clearly inhibited the activation of HGF induced by HLE and Cat G but not by PR3. HGF express PAR-1 and PAR-2 mRNA in the cells and the proteins on the cell surface. HLE and Cat G cleaved the peptide corresponding to the N terminus of PAR-2 with exposure of its tethered ligand. Treatment with trypsin, an agonist for PAR-2, and a synthetic PAR-2 agonist peptide induced intracellular Ca2+ mobilization and rendered cells refractory to subsequent stimulation with HLE and Cat G. The production of cytokine induced by HLE and Cat G and the PAR-2 agonist peptide was completely abolished by inhibition of phospholipase C. These findings suggest that neutrophil serine proteinases have equal ability to activate human nonepithelial cells through PAR-2 to produce inflammatory cytokines and may control a number of inflammatory processes such as periodontitis.
International Remittances and Income Inequality: An Empirical Investigation

Abstract Using several cross‐sectional and panel data methodologies, this paper provides evidence of the existence of an inverted U‐shaped relationship between international remittances and income inequality in a cross section of 78 countries. Our analysis supports previous theoretical work that describes how, at the first stages of migration history, there is an inequality‐increasing effect of remittances on income inequality. Then, as the opportunity cost of migrating decreases due to this effect, remittances tend to lower inequality. We also show how education and the development of the financial sector can help countries reach faster the inequality‐decreasing section of the curve.
TRIMETHOPRIM IS A POTASSIUM‐SPARING DIURETIC LIKE AMILORIDE AND CAUSES HYPERKALEMIA IN HIGH‐RISK PATIENTS

Trimethoprim-sulfamethoxazole is a commonly prescribed antimicrobial agent. Twenty-five years after its introduction into clinical practice, an unrecognized and potentially lethal adverse reaction associated with trimethoprim-sulfamethoxazole therapy, hyperkalemia, was described. Both “high-dose” and “standard-dose” trimethoprim-sulfamethoxazole have been associated with this electrolyte disorder. Recognition of this potassium disturbance led to the subsequent description of the mechanism by which trimethoprim-sulfamethoxazole induced hyperkalemia. Trimethoprim was found to act like the potassium-sparing diuretic amiloride and reduce renal potassium excretion. Hence, trimethoprim is in fact a potassium-sparing diuretic like amiloride and causes hyperkalemia in high-risk patients.
Capacitively Loaded Circularly Polarized Implantable Patch Antenna for ISM Band Biomedical Applications

A single-fed miniaturized circularly polarized microstrip patch antenna is designed and experimentally demonstrated for industrial-scientific-medical (2.4-2.48 GHz) biomedical applications. The proposed antenna is designed by utilizing the capacitive loading on the radiator. Compared with the initial topology of the proposed antenna, the so-called square patch antenna with a center-square slot, the proposed method has the advantage of good size reduction and good polarization purity. The footprint of the proposed antenna is 10×10×1.27 mm3. The simulated impedance, axial ratio, and radiation pattern are studied and compared in two simulation models: cubic skin phantom and Gustav voxel human body. The effect of different body phantoms is discussed to evaluate the sensitivity of the proposed antenna. The effect of coaxial cable is also discussed. Two typical approaches to address the biocompatibility issue for practical applications are reported as well. The simulated and measured impedance bandwidths in cubic skin phantom are 7.7% and 10.2%, respectively. The performance of the communication link between the implanted CP antenna and the external antenna is also presented.
Energy-based nonlinear control of hydraulically actuated mechanical systems

This contribution is devoted to a nonlinear energy based controller design for plants consisting of a mechanical 1-DOF load system coupled to a general hydraulic actuator. A systematic controller design which maintains the Port Hamiltonian structure of the plant is demonstrated for the case of a double-ended piston with only one servovalve. The developed controller shows good robustness properties and is able to inject additional damping into the load system without velocity measurement. Finally, the performance of the control law is demonstrated by application to a special industrial plant.
Virtual Environments for Assessing and Rehabilitating Cognitive/Functional Performance A Review of Projects at the USC Integrated Media Systems Center

Virtual reality (VR) technology offers new options for the creation of sophisticated tools that could be applied in the areas of assessment and rehabilitation of cognitive and functional processes. VR systems allow for the precise presentation and control of dynamic, multisensory, three-dimensional (3-D) stimulus environments, as well as the recording of all behavioral responses that occur within them. Assessment and rehabilitation scenarios that would be difficult if not impossible to deliver using conventional neuropsychological methods are now being developed that take advantage of these VR assets. If empirical studies demonstrate effectiveness, virtual environments (VEs) could be of considerable value for better understanding, measuring, and treating persons with impairments due to traumatic brain injury, neurological disorders, and learning disabilities. This article describes the progress of a VR research program at the USC Integrated Media Systems Center and Information Sciences Institute that has developed and investigated the use of a series of VEs designed to target (i) molecular visuospatial skills using a 3-D, projection-based ImmersaDesk system, and (ii) attention (and soon memory and executive functioning) processes within ecologically valid functional scenarios utilizing a head-mounted display (HMD). Results from completed research, rationales and methodology of works in progress, and our plan for future work is presented. Our primary vision has been to develop VR systems that target cognitive processes and functional skills that are of relevance to a wide range of patient populations with central nervous system (CNS) dysfunction, as well as for the assessment of unimpaired performance. We have also sought to select cognitive/functional targets that intuitively appear well matched to the specific assets available with currently available VR technology.
Femtosecond laser refractive surgery: small-incision lenticule extraction vs. femtosecond laser-assisted LASIK

Purpose of review Small-incision lenticule extraction (SMILE) is a novel technique devised to correct refractive errors. SMILE circumvents excimer laser photoablation of cornea, as the stromal lenticule cut by femtosecond laser is removed manually. Smaller incisions and preservation of anterior corneal biomechanical strength have been suggested as some of the advantages of SMILE over femtosecond laser-assisted LASIK (FS-LASIK). In this review, we compared previous published results of SMILE and FS-LASIK. The advantage, efficacy and safety of SMILE are compared with FS-LASIK. Recent findings SMILE achieved similar efficacy, predictability and safety as FS-LASIK. Greater preservations of corneal biomechanical strength and corneal nerves were observed in SMILE when compared with LASIK or PRK. Additionally, the incidence of postoperative dry eye syndrome was found to be less problematic in SMILE than in FS-LASIK. Summary SMILE is a promising new surgery for refractive error correction. Prospective and retrospective studies of SMILE have shown that results of SMILE are similar to FS-LASIK. With advances in femtosecond laser technology, SMILE may gain greater acceptance in the future.