Miracle-dz/UniFAR-FTUs huggingface dataset:
A Review of Gaps between Usability and Security/Privacy

Different domains of computing systems require higher level of focus towards specific quality factors like privacy, integrity, flexibility, usability etc. Moreover, certain quality factors help in each other’s existence while others oppose each other significantly. Usability of software applications is one factor that reduces security and privacy up to a substantial level. This paper examines the differences between usability factors and aspects related to security and privacy. A clear understanding of gaps between these two opposing factors has been presented in this paper. In addition, an account of efforts carried out to bridge these gaps has also been presented. We have divided these efforts into the categories of guidelines, frameworks and use of technology. The fields of e-banking and social networks have been considered specifically for identification of gaps in these particular fields.
[Current epidemiology of pediculosis capitis].

In schools of Touraine-France--usually more than 15% of the children are infected with capitis (investigation performed in 1987 and 1988). This number (rate) is rather close to the one that obtained in previous two investigations (1974 and 1981). Hence Pediculosis is not progressing. It may however be noticed that, as more and more families become aware of this problem, more and more cures are undertaken (4,656,000 units sold in 1989 versus 2,793,000 in 1984. Then it seems that the most employed pediculosides (pyrethroïds) are less efficient than a few years ago. In fact lices are becoming resistant to these drugs. 4 kinds of complementary actions are in fact necessary: information of the public about the lice biology and necessity of SIMULTANEOUS COMMUNITY cures; prevalence analysis by means of standard sample grids; coordination of all the partners: city administration, medical, paramedical and social staff, family workers, teachers, even children judges. in view of actions from the personal level up to the global one; estimate of the effectiveness of these activities. This strategy, which has been experimented in Touraine, has proved its efficiency at short and long term: we have observed a durable decrease of pediculosis the prevalence of which has diminished from 18.3% down to 5.5% in the 3 school chosen as experiment locations.
What is the source of observed annual variations in plasmaspheric density

Plasmaspheric densities have been observed previously to be higher in December than in June, with the ratio varying between 1.5 and 3.0 and with larger variations at lower L shells. In order to search for the cause of the observed annual variations, we have modeled plasmaspheric density, using a time-dependent hydrodynamic model. On an L = 2 field line with geomagnetic longitude equal to 300°, the modeled plasmaspheric densities were a factor of 1.5 times higher in December than in June. The modeled December to June density ratio was found to increase slightly with L shell, in contrast to observations; this discrepancy may be due to the fact that outer plasmaspheric flux tubes are never completely full. In addition, for an L = 2 field line with geomagnetic longitude equal to 120°, the modeled plasmaspheric density was higher in June than in December by a factor of about 1.2. Various numerical tests were also performed in order to examine the sensitivity of plasmaspheric density to various parameters. In particular, a large vertical neutral wind was applied in order to raise the O+ profile, which had the effect of raising plasmaspheric density by a factor of 6. This in conjunction with a theoretical analysis suggests that plasmaspheric density levels are very sensitive to O+ levels in the upper ionosphere. We conclude that annual variations in plasmaspheric density are due to similar variations in ionospheric O+.
Do people recognise mental illness? Factors influencing mental health literacy.

BACKGROUND Mental health literacy has been defined as the public's knowledge and the beliefs about mental disorders enhancing the ability to recognise specific disorders. AIMS Firstly, to determine whether the public recognises a person depicted in a vignette as mentally ill or as experiencing a crisis. Secondly, to reveal the factors influencing the correct recognition. METHODS Multiple logistic regression analysis of an opinion survey conducted in a representative population sample in Switzerland (n=844). RESULTS The depression vignette was correctly recognised by 39.8% whereas 60.2% of the respondents considered the person depicted as having a 'crisis. ' The schizophrenia vignette was correctly identified by 73.6% of the interviewees. A positive attitude to psychopharmacology positively influenced the recognition of the two vignettes whereas a positive attitude to community psychiatry had the inverse effect. Moreover, for the depression vignette previous contact to mentally ill people had a positive influence on the recognition. For the schizophrenia vignette instead, rigidity and interest in mass media had a negative influence, respectively. CONCLUSIONS The low knowledge about mental disorders, particularly depression, confirms the importance and the need to increase mental health literacy. Furthermore, professionals must openly discuss illness models with their patients, especially emphasising the differences between illness and crisis.
Innkeeper at the Roach Motel

Library-run institutional repositories face a crossroads: adapt or die. The “build it and they will come” proposition has been decisively proven wrong. Citation advantages and preservation have not attracted faculty participants, though current-generation software and services offer faculty little else. Academic librarianship has not supported repositories or their managers. Most libraries consistently under-resource and understaff repositories, further worsening the participation gap. Software and services have been wildly out of touch with faculty needs and the realities of repository management. These problems are not insoluble, especially in light of Harvard University arts and science faculty’s recent permissions mandate, but they demand serious reconsideration of repository missions, goals, and means if we are to be ready for Harvard imitators, and especially to be ready should those imitators not surface.
Actividad oscilatoria neuronal asociada con la orientación de la atención hacia las representaciones mentales de la memoria operativa

Los mecanismos de atencion selectiva nos permiten seleccionar la informacion que es importante para el comportamiento y desechar aquella que es irrelevante. La sincronizacion neuronal se ha propuesto como un mecanismo esencial subyacente a la atencion selectiva. Algunos modelos postulan que las oscilaciones en banda de frecuencia gamma y alpha tienen un papel primordial en la orientacion de la atencion con roles antagonistas. Estudios recientes muestran que al igual que la atencion en el espacio perceptivo ejerce un sesgo a favor del estimulo atendido, tambien es posible orientar la atencion al espacio representacional de la memoria operativa. En esta tesis doctoral se exploran los mecanismos oscilatorios asociados a la orientacion de la atencion a las representaciones mnemicos, bajo la hipotesis de que el patron oscilatorio sera similar al ya encontrado en estudios perceptivos.
Pneumococcal Polysaccharides Interact with Human Dendritic Cells

ABSTRACT Dendritic cells (DCs) are critical antigen presentation cells whose influence on murine immune responses to polysaccharide antigens has only recently been elucidated. Little is known about human DC-polysaccharide interactions. We set out to study the interaction between human monocyte-derived DCs and pneumococcal capsular polysaccharides (PPS) in vitro. Immature DCs were generated from peripheral blood monocytes and incubated with fluorescein isothiocyanate-labeled PPS type 9N or 14 for assessment of uptake. DCs were exposed to PPS type 1, 6B, 9N, 14, 19F, or 23F in the absence or presence of Escherichia coli lipopolysaccharide (LPS) for assessment of phenotypic DC maturation and cytokine production. PPS were taken up by immature DCs and proceeded to HLA-DR+ and lysosome-associated membrane protein-1+ late endosomal compartments. Uptake was reduced in the presence of cytochalasin D and wortmannin, suggesting that both cytoskeletal rearrangements and phosphatidylinositol 3-kinase activation may be required for internalization. None of the PPS tested induced DC phenotype changes, maturation, or interleukin-12 (IL-12)/IL-10 production. However, PPS were capable of modulating the response of the DCs to a second signal such as LPS. Exposure of DCs to PPS in the presence of LPS resulted in an altered cytokine balance with significantly increased IL-10 production and reduced IL-12 production compared to LPS alone. This effect was not seen using the control antigen tetanus toxoid. DC-pneumococcus interaction may affect subsequent immune responses to pneumococci, as an altered cytokine balance may have a profound effect on DC-driven T-cell priming.
Framing the grid: effect of boundaries on grid cells and navigation

Cells in the mammalian hippocampal formation subserve neuronal representations of environmental location and support navigation in familiar environments. Grid cells constitute one of the main cell types in the hippocampal formation and are widely believed to represent a universal metric of space independent of external stimuli. Recent evidence showing that grid symmetry is distorted in non‐symmetrical environments suggests that a re‐examination of this hypothesis is warranted. In this review we will discuss behavioural and physiological evidence for how environmental shape and in particular enclosure boundaries influence grid cell firing properties. We propose that grid cells encode the geometric layout of enclosures.
Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data

This article provides an overview of the clinical evidence of interactions between herbal and conventional medicines. Herbs involved in drug interactions – or that have been evaluated in pharmacokinetic trials – are discussed in this review. While many of the interactions reported are of limited clinical significance and many herbal products (e.g. black cohosh, saw palmetto, echinacea, hawthorn and valerian) seem to expose patients to minor risk under conventional pharmacotherapy, a few herbs, notably St. John’s wort, may provoke adverse events sufficiently serious to endanger the patients’ health. Healthcare professionals should remain vigilant for potential interactions between herbal medicines and prescribed drugs, especially when drugs with a narrow therapeutic index are used.
The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum

Drug addiction is a chronic, debilitating disease that affects millions of people around the world causing a substantial societal burden. Despite decades of research efforts, treatment possibilities remain limited and relapse represents the most treatment-resistant element. Neurosteroid sigma-1 receptors have been meticulously studied in psychostimulant reinforced Pavlovian learning, while the sigma-2 receptor subtype has remained unexplored. Recent development of selective sigma-2 receptor ligands have now made it possible to investigate if the sigma-2 receptor system is a potential target to treat drug addiction. We examined the effect of the sigma-2 receptor agonist Siramesine (Lu 28-179) on cocaine-associated locomotion, Pavlovian learning, and reward neurocircuitry using electrophysiology recordings and in vivo microdialysis. We found that Siramesine significantly attenuated conditioned place preference acquisition and expression, as well as it completely blocked cocaine-primed reinstatement. Siramesine, in a similar manner as the selective sigma-1 receptor antagonist BD 1063, decreased acute locomotor responses to cocaine. Immunohistochemistry suggests co-expression of progesterone receptor membrane component 1/sigma-2 receptors and vesicular glutamate transporter 1 in presynaptic boutons of the nucleus accumbens (NAc). Whole-cell voltage clamp recordings of neurons in the NAc indicated that Siramesine decreases the presynaptic release probability of glutamate. Further, we demonstrated, via in vivo microdialysis, that Siramesine significantly decreased cocaine-evoked dopamine release in the striatum of freely moving mice. Collectively, these findings demonstrate that sigma-2 receptors regulate neurocircuitry responsible for positive reinforcement and thereby play a role in cocaine-reinforced Pavlovian behaviors.
Cholinergic and GABAergic modulation of medial septal area: effect on working memory.

The role of the septohippocampal pathway in working memory was investigated by direct microinfusion of compounds into the medial septal area (MSA). Behavior was measured by performance in a continuous spatial alteration task in a T maze, and hippocampal theta rhythm was also recorded. Intraseptal saline had no effect on choice accuracy or hippocampal theta rhythm. Tetracaine decreased choice accuracy and theta rhythm 10 min, but not 90 min, after infusion. Likewise, muscimol and scopolamine produced a transient, dose-dependent suppression of hippocampal theta rhythm and a simultaneous dose-dependent impairment in choice accuracy. A significant correlation (r = .78) emerged between a compound's influence on theta rhythm and its effect on choice accuracy. The data support a role for the septohippocampal projection in working memory and suggest that gamma-aminobutyric acid and acetylcholine may have opposing influences on neurons in the MSA.
Multifidus Muscle Recovery Is Not Automatic After Resolution of Acute, First‐Episode Low Back Pain

Study Design A clinical study was conducted on 39 patients with acute, first‐episode, unilateral low back pain and unilateral, segmental inhibition of the multifidus muscle. Patients were allocated randomly to a control or treatment group. Objectives To document the natural course of lumbar multifidus recovery and to evaluate the effectiveness of specific, localized, exercise therapy on muscle recovery. Summary of Background Data Acute low back pain usually resolves spontaneously, but the recurrence rate is high. Inhibition of multifidus occurs with acute, first‐episode, low back pain, and pathologic changes in this muscle have been linked with poor outcome and recurrence of symptoms. Methods Patients in group 1 received medical treatment only. Patients in group 2 received medical treatment and specific, localized, exercise therapy. Outcome measures for both groups included 4 weekly assessments of pain, disability, range of motion, and size of the multifidus cross‐sectional area. Independent examiners were blinded to group allocation. Patients were reassessed at a 10‐week follow‐up examination. Results Multifidus muscle recovery was not spontaneous on remission of painful symptoms in patients in group 1. Muscle recovery was more rapid and more complete in patients in group 2 who received exercise therapy (P = 0.0001). Other outcome measurements were similar for the two groups at the 4‐week examination. Although they resumed normal levels of activity, patients in group 1 still had decreased multifidus muscle size at the 10‐week follow‐up examination. Conclusions Multifidus muscle recovery is not spontaneous on remission of painful symptoms. Lack of localized, muscle support may be one reason for the high recurrence rate of low back pain following the initial episode.
A randomized controlled trial of a mother-infant or toddler parenting program: demonstrating effectiveness in practice.

OBJECTIVE Describes outcomes of an intervention aimed to improve infant or toddler care and reduce parental distress. METHODS A randomized controlled trial method was used with 118 mothers. Participants were allocated to an intervention group (n = 65) or an enhanced waitlist group (n = 53). Measures were taken at pre-, post-, and 6-weeks follow-up. RESULTS Results demonstrated that mothers who attended the program reported improvement in depression, anxiety, stress, parental satisfaction, and decreases in problematic child behavior. Improvements were maintained at the 6-week follow up. Intention-to-treat analysis replicated the results, although with smaller effect sizes. CONCLUSIONS The results of this study demonstrate that delivery of a 1 day intervention for distressed mothers can contribute to lower levels of parental distress and child problem behavior. Given the importance of early mother-child relationships and the limited number of well-controlled studies on brief interventions this result is of significance to researchers and the service community.
The Tourism Demand of Nonlinear Combination Forecasting based on Time Series Method and WNN

The combination forecasting model IOWGA-EMD-ARMA-WNN is proposed in this paper. The randomness, periodicity and tendency of the original data are showed by EMD decomposition in EMD-ARMA model. WNN combines the advantages of wavelet analysis and BP neural network and improves the learning efficiency and forecasting accuracy. The weight of combination model is decided by forecasting precision of EMD-ARMA model and WNN model based on IOWGA method. At last, the IOWGA-EMD-ARMA-WNN model is used to forecast monthly inboard tourism demand of China and the results show that the proposed combination model has better performance on forecasting accuracy compared with the other models.
Arabidopsis hybrid speciation processes

The genus Arabidopsis provides a unique opportunity to study fundamental biological questions in plant sciences using the diploid model species Arabidopsis thaliana and Arabidopsis lyrata. However, only a few studies have focused on introgression and hybrid speciation in Arabidopsis, although polyploidy is a common phenomenon within this genus. More recently, there is growing evidence of significant gene flow between the various Arabidopsis species. So far, we know Arabidopsis suecica and Arabidopsis kamchatica as fully stabilized allopolyploid species. Both species evolved during Pleistocene glaciation and deglaciation cycles in Fennoscandinavia and the amphi-Beringian region, respectively. These hybrid studies were conducted either on a phylogeographic scale or reconstructed experimentally in the laboratory. In our study we focus at a regional and population level. Our research area is located in the foothills of the eastern Austrian Alps, where two Arabidopsis species, Arabidopsis arenosa and A. lyrata ssp. petraea, are sympatrically distributed. Our hypothesis of genetic introgression, migration, and adaptation to the changing environment during the Pleistocene has been confirmed: We observed significant, mainly unidirectional gene flow between the two species, which has given rise to the tetraploid A. lyrata. This cytotype was able to escape from the narrow ecological niche occupied by diploid A. lyrata ssp. petraea on limestone outcrops by migrating northward into siliceous areas, leaving behind a trail of genetic differentiation.
Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila

Legionella pneumophila is an environmental bacterium and the causative agent of Legionnaires’ disease. Previous genomic studies have shown that recombination accounts for a high proportion (>96%) of diversity within several major disease-associated sequence types (STs) of L. pneumophila. This suggests that recombination represents a potentially important force shaping adaptation and virulence. Despite this, little is known about the biological effects of recombination in L. pneumophila, particularly with regards to homologous recombination (whereby genes are replaced with alternative allelic variants). Using newly available population genomic data, we have disentangled events arising from homologous and non-homologous recombination in six major disease-associated STs of L. pneumophila (subsp. pneumophila), and subsequently performed a detailed characterisation of the dynamics and impact of homologous recombination. We identified genomic “hotspots” of homologous recombination that include regions containing outer membrane proteins, the lipopolysaccharide (LPS) region and Dot/Icm effectors, which provide interesting clues to the selection pressures faced by L. pneumophila. Inference of the origin of the recombined regions showed that isolates have most frequently imported DNA from isolates belonging to their own clade, but also occasionally from other major clades of the same subspecies. This supports the hypothesis that the possibility for horizontal exchange of new adaptations between major clades of the subspecies may have been a critical factor in the recent emergence of several clinically important STs from diverse genomic backgrounds. However, acquisition of recombined regions from another subspecies, L. pneumophila subsp. fraseri, was rarely observed, suggesting the existence of a recombination barrier and/or the possibility of ongoing speciation between the two subspecies. Finally, we suggest that multi-fragment recombination may occur in L. pneumophila, whereby multiple non-contiguous segments that originate from the same molecule of donor DNA are imported into a recipient genome during a single episode of recombination.
Outcomes of Add‐on Treatment with Lamotrigine in Partial Epilepsy

Summary: The need for new antiepileptic drugs (AEDs) and more sensitive methods of assessing their efficacy is well recognized. This study was designed to evaluate the efficacy and safety of lamotrigine (LTG), a potential new AED and to develop and test new outcome measures. A health‐related quality of life (HRQL) model was developed which contains previously validated measures of anxiety, depression, happiness, overall mood, self‐esteem, and mastery and a specifically designed seizure severity scale with patient‐ and caregiver‐based components. This HRQL model was used in a randomized, placebo‐controlled, double‐blind, cross‐over study of LTG in 81 patients with refractory partial seizures. Seizure frequency was the primary measure and seizure severity and the HRQL were secondary measures of efficacy. The reduction in seizure frequency with LTG, relative to placebo, was 29.7% [95% confidence interval (CI) 17.8%, 39.9%] for total seizure count, 33.4% (95% CI 14.8%, 47.9%) for complex partial seizures (CPS) and 20.3% (95% CI 0.3%, 36.2%) for secondarily generalized tonic‐clonic seizures (GTCS). However, although 41 patients elected to continue with LTG, only 11 experienced at least 50% reduction in total seizures, indicating that other factors influenced their decision. The score with LTG, relative to placebo, was significantly lower for the ictal (p = 0.017) and caregivers (p = 0.035) subscales of the seizure severity scale and significantly higher for happiness (p = 0.003) and mastery (p = 0.003). Simple correlation and multiple‐regression analyses indicate that the effects on seizure frequency, seizure severity, and psychological variables appear to be independent of each other. This study indicates that LTG is effective in reducing seizure frequency and has additional favorable effects on seizure severity, mood, and perceived internal control. Some of the scales used indicate the potential of secondary measures of efficacy to enhance the sensitivity of trials of new AEDs.