Miracle-dz/UniFAR-FTUs huggingface dataset:
Global priority critical pathogens-its prevalence and molecular epidemiology in Arar tertiary care hospital, Saudi Arabia

Jayakumar Subramaniam1, Mohamed Soliman1, Jamith Basha Abdul Wahid2, Khalid Mohammed Refaat3, Sana Abdelkareem Alsadrah4 1Department of Microbiology, Faculty of Medicine, Northern Border University, Arar, 2Department of Microbiology, Faculty of Applied Medical Science, Northern Border University, Arar, 3Microbiology Diagnostic Lab, Arar Central Hospital , Ministry of Health, 4Department of Preventive Medicine, Governmental Hospital Khobar, Health Centres in Khobar, Ministry of Health, Saudi Arabia Prevalence of global priority critical pathogens Global priority critical pathogens-its prevalence and molecular epidemiology in Arar tertiary care hospital, Saudi Arabia
Cardiovascular Sequelae of Hypokalemia in Hemodialysis Patients

Background: Dyskalemia is a serious condition that encountered in End-Stage Renal Disease (ESRD) patients maintained on hemodialysis that may affect their prognosis. We aimed to investigate consequences of dyskalemia in such patients.Patients and methods: Two-hundred hemodialysis patients underwent laboratory assessment of hemoglobin, blood sugar, renal function, serum albumin, parathormone, ferritin, ionized-calcium and phosphorus. Serum potassium was estimated before and within 2 hour after dialysis. Electrocardiogram (ECG) was obtained just before dialysis session. Transthoracic echocardiography was obtained within 2 hour after dialysis; estimating ventricular systolic and diastolic functions and pulmonary pressure. Twelve-month followed-up was undertaken for mortality.Results: Patients were divided according to pre-dialysis potassium into hypokalemic (n=26), hyperkalemic (n=56) and normokalemic groups (n=118). Hypokalemic group were older with longer dialysis duration (p<0.001). Dietary potassium varied significantly among groups, with more concomitant medications used in hyperkalemic group (p<0.001). Hypokalemic group showed higher Blood Pressure (BP) (p=0.002), while hyperkalemic group showed lower heart rate (p=0.012). Lower serum albumin and calcium, higher urea, creatinine, phosphorus andparathormone levels were in hyperkalemic group (p<0.001). Hypokalemic group showed evident ECG changes (p=0.024), increased Left Ventricle (LV) mass (p=0.032) and diastolic dysfunction (P<0.001). Although tendency toward higher mortality in hypo and hyperkalemic groups, no significant difference was observed (p=0.19). Predialysis potassium was negatively correlated with dialysis duration (p<0.001), diastolic BP (p=0.042) and LV mass (p=0.018), and positively correlated with hemoglobin level (p=0.017), serum albumin, phosphorus and parathormone(p<0.001). Conclusion: Hypokalemia is as serious as hyperkalemia, being associated with significant cardiovascular consequences in patients on maintenance hemodialysis.
Effect of AcrySof versus other intraocular lens properties on the risk of Nd:YAG capsulotomy after cataract surgery: A systematic literature review and network meta-analysis

Objective The purpose of this study was to evaluate the impact of different intraocular lens materials (IOL) and optic edge designs on the incidence of Nd:YAG laser capsulotomy. Methods Randomized controlled trials (RCTs) reporting incidence of Nd:YAG capsulotomy in patients with monofocal IOLs were identified for systematic literature review (SLR) using Cochrane methodology. A network meta-analysis was conducted under a Bayesian framework. Mean hazard ratios (HRs), 95% credible intervals, and one-sided p-values were estimated for Nd:YAG capsulotomy incidence by comparing AcrySof IOLs with a group of non-AcrySof hydrophobic acrylic, hydrophilic acrylic, silicone, and PMMA IOLs. Sensitivity analysis was conducted comparing the risk of Nd:YAG capsulotomy between sharp- and round-edged designs of the above IOLs. Results AcrySof IOLs had a lower risk of Nd:YAG capsulotomy compared to hydrophobic acrylic (HR: 2.68; 95% CrI: 1.41, 4.77; p < 0.01), hydrophilic acrylic (HR: 7.54; 95% CrI: 4.24, 14.06; p < 0.001), PMMA (HR: 3.64, 95% CrI: 1.87, 6.33; p < 0.001), and silicone (HR: 1.13; 95% CrI: 0.59, 1.91; p <0.1) IOLs. The risk for Nd:YAG was highest among sharp-edged IOLs for hydrophilic acrylic IOLs (HR: 9.32; 95% CrI: 4.32, 19.29; p < 0.01), followed by other hydrophobic acrylic (HR: 2.91; 95% CrI: 1.27, 5.88; p < 0.01), silicone (HR: 0.838; 95% CrI: 0.328, 1.74; p = 0.69), and PMMA (HR: 0.39; 95% CrI: 0.042, 1.49; p = 0.93) IOLs, compared to AcrySof. Acrysof IOLs had a lower risk of Nd:YAG compared to PMMA (HR: 3.25; 95% CrI: 1.21, 7.37; p < 0.01) and silicone, round edge IOLs (HR: 3.84; 95% CrI: 1.08, 10.64; p = 0.015). Conclusion The risk of Nd:YAG capsulotomy is lower in eyes implanted with AcrySof IOLs compared to non-AcrySof hydrophobic or hydrophilic acrylic IOLs. Sharp-edged AcrySof, PMMA, and silicone IOLs are comparable in terms of reducing the risk of Nd:YAG laser capsulotomy.
A study on the symptom profile of depressive disorder in elderly Turkish patients: A factor analysis study

Aim: Depressive disorder manifests itself differently in elderly patients due to the symptom profile. We conducted this study on a population of elderly major depressive disorder patients in Turkey with the aim of determining the sociodemographic characteristics, distribution, and associations of their symptoms. Material and Method: A retrospective study of 137 patients hospitalized during the last ten years in the Geropsychiatric Clinic of the Department of Psychiatry, Cerrahpaşa School of Medicine, Istanbul University. The patients were diagnosed according to the DSM IV criteria. Results: Majority (51.8%) of the patients were female, most of which were married (65%). The most common symptoms in elderly patients in order of frequency were distress 112 (81.8%) anxiety 97 (70.8%), and insomnia 96 (70.1%). The least frequently observed symptoms were disorientation 5 (3.6%), nihilistic delusions 5 (3.6%), and increased appetite 2 (2.2%). The symptoms clustered in accordance with the DSM IV system. Conclusion: It was concluded that the sociodemographic characteristics and weighted distribution of symptoms in Turkish geriatric depression patients were closely in parallel with the existing literature. However, results indicate a need to repeat this study in order to explore the same in a general Turkish population.
Molecular Changes in Diabetic Wound Healing following Administration of Vitamin D and Ginger Supplements: Biochemical and Molecular Experimental Study

Background Circulating micro-RNAs are differentially expressed in various tissues and could be considered as potential regulatory biomarkers for T2DM and related complications, such as chronic wounds. Aim In the current study, we investigated whether ginger extract enriched with [6]-gingerol-fractions either alone or in combination with vitamin D accelerates diabetic wound healing and explores underlying molecular changes in the expression of miRNA and their predicted role in diabetic wound healing. Methods Diabetic wounded mice were treated with [6]-gingerol-fractions (GF) (25 mg/kg of body weight) either alone or in combination with vitamin D (100 ng/kg per day) for two weeks. Circulating miRNA profile, fibrogenesis markers, hydroxyproline (HPX), fibronectin (FN), and collagen deposition, diabetic control variables, FBS, HbA1c, C-peptide, and insulin, and wound closure rate and histomorphometric analyses were, respectively, measured at days 3, 6, 9, and 15 by RT–PCR and immunoassay analysis. Results Treatment of diabetic wounds with GF and vitamin D showed significant improvement in wound healing as measured by higher expression levels of HPX, FN, collagen, accelerated wound closure, complete epithelialization, and scar formation in short periods (11-13 days, (P < 0.01). On a molecular level, three circulating miRNAs, miR-155, miR-146a, and miR-15a, were identified in diabetic and nondiabetic skin wounds by PCR analysis. Lower expression in miR-155 levels and higher expression of miR-146a and miR-15a levels were observed in diabetic skin wounds following treatment with gingerols fractions and vitamin D for 15 days. The data showed that miRNAs, miR-146a, miR-155, and miR-15a, correlated positively with the expression levels of HPX, FN, and collagen and negatively with FBS, HbA1c, C-peptide, and insulin in diabetic wounds following treatment with GF and /or vitamin D, respectively. Conclusion Treatment with gingerols fractions (GF) and vitamin D for two weeks significantly improves delayed diabetic wound healing. The data showed that vitamin D and gingerol activate vascularization, fibrin deposition (HPX, FN, and collagen), and myofibroblasts in such manner to synthesize new tissues and help in the scar formation. Accordingly, three miRNAs, miR-155, miR-146a, and miR-15, as molecular targets, were identified and significantly evaluated in wound healing process. It showed significant association with fibrin deposition, vascularization, and reepithelialization process following treatment with GF and vitamin D. It proposed having anti-inflammatory action and promoting new tissue formation via vascularization process during the wound healing. Therefore, it is very interesting to consider miRNAs as molecular targets for evaluating the efficiency of nondrug therapy in the regulation of wound healing process.
Single/two-step scaffold-based cartilage repair in the knee and ankle joint

Articular (chondral) cartilage is a thin layer of connective tissue. A damage of the cartilage can occur due to traumatic events, degeneration of the joint or due to osteochondritis dissecans. In this report, we analysed whether single-step/two-step scaffold-based cartilage repair (AMIC/MACI) is more effective and safer in comparison to microfracturing (MFx) or as effective but safer in comparison to autologous chondrocyte implantation. In total, for the knee joint data from six controlled trials for AMIC and five randomised controlled trials for MACI that met our inclusion criteria were extracted. No controlled trials for the ankle joint were identified. Overall, the level of evidence was rated as "very low" to "low" for the outcomes of clinical effectiveness and safety. The current evidence is not sufficient to conclude that AMIC or MACI is more effective and safer than MFx or as effective, but safer than ACI. We currently do not recommend the inclusion of the procedures in the Austrian hospital benefit catalogue. A re-evaluation of AMIC is recommended not before 2022 and of MACI not before 2021, as the publication of ongoing RCTs is to be awaited.
Correlations between Malocclusion and Postural Anomalies in Children with Mixed Dentition

The aim of this study was to investigate the possible relationship between malocclusion and body posture anomalies. The original sample involved 127 children (45 males and 82 females) with mixed dentition. Clinical examination of oral cavity was performed by an orthodontist, who recorded molar and canine relationship, cross-bite, lower middle-line deviation, and centric relation (CR) considering mono or bilateral contacts in CR. Orthopedic examination of the body posture was clinically carried out by an orthopedist who detected anomalies such as scoliosis, false scoliosis or paramorphism, kyphosis and lordosis. Of the 127 subjects of the sample, 18 children were orthopedically normal, 80 patients had false scoliosis, 22 scoliosis and 7 showed kyphosis. In our study, we don’t consider the 7 patients with kyphosis for the exiguity of the sample; so, our analysis was performed on 120 children (42 males and 78 females). The results obtained revealed that the cross-bite was more frequent when scoliosis became worse. We also found that the relationship between left cross-bite and contralateral side of deviation of the curve of the spine in subjects with scoliosis is statistically significant (p = 0.002). Furthermore, the relationship between lower midline and contralateral side of deviation of the curve of the spine in patients with false scoliosis is statistically significant (p = 0.003). In conclusion, it seems that posture anomalies are correlated to cross-bite and mandible abnormal position.
The physiological demands of 'hiking' on dinghy sailors

The purpose of the studies presented in this thesis was to combine on-water and off-water measurements in order to investigate the physiological demands of the major physical challenge in dinghy sailing: the '"hiking" effort, which is performed in order to counterbalance a dinghy in moderate and stronger winds. This purpose was achieved by:-1) Investigating the course of a number of physiological variables under actual sailing conditions. 2) Using this information to closely simulate sailing in the laboratory. 3) Investigating in the laboratory a number of physiological variables which could not be studied under real sailing conditions. On the basis of the resultant findings sailing-specific training regimes were administered to sailors to assist them in maximising hiking performance. The use of portable telemetry allowed investigation of a number of cardiorespiratory parameters during actual sailing conditions. A series of on- water measurements revealed that aerobic capacity is only moderately taxed in dinghy sailing (39.5 +/- 6.0 % VO2 max at wind-speeds of between 4 and 12 ms-1 in 'Laser' dinghies) whereas the cardiac and respiratory functions are taxed proportionally more, thus leading to a marked tachycardia (74 +/- 10 % HR max) and hyperventilation (VE/VO2: 26.8 +/- 1.6). Blood lactate concentration measurements suggested that anaerobic metabolism plays an increasing role in stronger winds. The causes of tachycardia and hyperventilation were further investigated during simulated hiking. The latter investigation offered evidence of a direct association between the onset and magnitude of fatigue in quadriceps muscle groups and the cardiovascular and ventilatory drives. The development of muscular fatigue, which was mirrored in the progressive increase in the quadriceps EMG activity, is likely to have led, directly or indirectly, to the progressive tachycardia and hyperventilation. These changes in HR, VE and EMG activity occurred in the absence of changes in the lactate concentration. Further EMG measurements carried out during simulated hiking suggests that fatigue in quadriceps is due to the high degree to which these muscles were activated during hiking (approximately 30 % maximum) and that it seems reasonable to believe that local muscular fatigue is the most likely factor to limit hiking performance. Although an improvement in hiking performance was achieved after the administration of different training regimes, the present findings offer no conclusive evidence of the mechanisms responsible for resisting fatigue in quadriceps and thus maximising hiking performance. It was concluded that training regimes for sailors should not emphasise aerobic fitness but the local static endurance of the thigh muscles.
Resistance Patterns of Escherichia coli and Klebsiella pneumoniae Bacteria Against Amikacin, Ceftazidime, Meropenem, Nitrofurantoin Antibiotics in Elderly Patients with UTI in RSUD Dr. Soetomo

Introduction: Urinary tract infection (UTI) is an infection that involves the urinary tract, including the urethra, bladder, ureter, and kidneys. UTI is caused by microorganisms that breed in the urinary tract which are supposed to be free of microorganisms. Two bacterias that cause UTI in general are Escherichia coli and Klebsiella pneumoniae. UTI can occur at any age but generally occurs in the elderly. UTI caused by gram-negative bacteria can be killed with several examples of antibiotics namely amikacin, ceftazidime, meropenem and nitrofurantoin. These antibiotics found resistance to the bacteria that cause the UTI. This research is to determine the resistance patterns of Escherichia coli and Klebsiella pneumoniae bacteria against amikacin, ceftazidime, meropenem, nitrofurantoin antibiotics in elderly patients with UTI in Dr. Soetomo Surabaya January-June 2017 period.Methods: A descriptive retrospective study in accordance with the logbook data of Clinical Microbiology Installation at Dr. RSUD. Soetomo Surabaya. Data from this study were taken from all populations that met the inclusion criteria. The results are presented by tables. Results: There are 163 elderly patient data which diagnosed with urinary tract infection. Escherichia coli resistance pattern against ceftazidime (75.6%), nitrofurantoin (12.6%) and meropenem (2.4%). Meanwhile, Klebsiella pneumoniae against ceftazidime (72.2%), nitrofurantoin (55.6%), meropenem (11.1%) and amikacin (2.8%). Conclusion: There were resistance number of Escherichia coli and Klebsiella pneumoniae bacteria against antibiotics amikacin, ceftazidime, meropenem, nitrofurantoin in elderly patients with UTI.
Streptococcus mutans isolated from a 4‐year‐old girl diagnosed with infective endocarditis

Infective endocarditis (IE) has an extremely high fatality rate. In this study, we isolated a strain of Streptococcus mutans, which we called HM, from the blood drawn from a 4‐year‐old girl diagnosed with IE. We aimed to fully type the HM strain and investigate its biological properties, including its virulence with respect to IE.
A correlational study of hope and its relationship with spiritual health on hemodialysis patients

BACKGROUND: One of the main psychological problems in hemodialysis patients is hopelessness. Spiritual health leads the patients toward hope and goal in life. Given the importance of the issue and the little research in this area, this study aimed to assess hope and its relationship with spiritual health on hemodialysis patients in Rasht Razi Hospital of Iran. MATERIALS AND METHODS: This correlational study carried out on 103 patients who admitted in Rasht Razi Hospital Hemodialysis Center by simple random sampling. The data were collected through Snyder's Hope Scale and Spiritual Health. The psychomotricity of these questionnaires has been confirmed in domestic studies. The data were analyzed by using descriptive and inferential statistics (Pearson correlation coefficient). RESULTS: The majority of the patients were male (59.2%), in the age group of above 60 (46.60%), married (83.5%), with low income (60.2%), and under diploma (53.4%). The mean of hope score was 36.36 (±9.10) that showed the high level of hope in the majority of the patients. The mean of the total spiritual health score was 227.93 (±19.01) that indicates the high level of spiritual health in hemodialysis patients. There was a positive and significant correlation between spiritual health and its dimensions and hope (P < 0.05). CONCLUSIONS: The results of this study approve the importance of spiritual health as an effective variable on hope among hemodialysis patients. Hence, health-care providers and clinical experts are recommended to focus on spiritual health to increase hope among such patients.
Nurses’ preparedness in responding to patients with suspected sexually transmitted infections in the rural health unit

The objective of this study was to assess the level of preparedness of rural health unit nurses in responding to patients with suspected sexually transmitted infections (STIs) in Lanao Del Sur Province, Philippines. A total of 147 nurses participated in the study from 39 rural health unit facilities using Cochran formula. The study used a self-administered questionnaire (SAQ) adapted from the Philippines’ Department of Health (DOH) Manual for Training in Care and Prevention of STIs. The study revealed that the rural health unit (RHU) health care facilities and services, supplies and equipment, and training and seminars for STIs program were inadequate as perceived by rural health unit nurses. Furthermore, the result showed that the rural health unit (RHU) nurse respondents perceived themselves to be very prepared (x ̅ =21.30, SD± 2.36) in responding to patients with suspected STIs. Specifically, rural health nurses were very prepared in terms of attitude and behavior (x ̅ =35.9, SD± 3.61), communication (x ̅ =18.8, SD± 1.81), health assessment (x ̅ =18.6, SD± 2.11), prevention of transmission (x ̅ =18.7, SD± 1.95), contact tracing (x ̅ =17.2, SD± 2.47), and confidentiality (x ̅ =18.6, SD± 2.22). The study revealed a significant relationship between demographic profile and the perceived level of preparedness. The study concluded that rural health nurses are very prepared
A survey of critical care pharmacists to patient ratios and practice characteristics in intensive care units

Pharmacists are widely recognized members of the critical care health care team. However, unlike other health care professions, critical care pharmacists do not have standardized pharmacist to patient ratios that establish maximal cost‐efficiency while maintaining optimal patient safety. Though many prior recommendations claim a ratio of 1:15 for safe pharmacy practice, recommendations have ranged as low as 1:8 to as high as 1:30.
ANEMIA PADA REMAJA PUTRI DIPENGARUHI OLEH TINGKAT PENGETAHUAN TENTANG ANEMIA

Berbagai permasalahan kesehatan sering terjadi pada remaja terkait dengan masa menstruasi adalah risiko Ca Payudara, Ca Rahim dan risiko Anemia. Anemia adalah suatu keadaan dimana kadar hemoglobin dalam darah kurang dari normal, yaitu 11,5 – 16,5 gr/dl untuk perempuan dan 12,5 0- 18,5 gr/dl untuk laki – laki. Tujuan Penelitian adalah ingin mengetahui hubungan pengetahuan tentang anemia dengan kejadian anemia pada remaja putri di Madrasah Aliyah Mathla’ul Anwar Gisting Kabupaten Tanggamus Tahun 2015. Metode Penelitian ini merupakan penelitian survei dengan jenis penelitian analitik, dengan pendekatan cross sectional . Populasi dalam penelitian ini adalah seluruh remaja putrid (siswi kelas 10 dan 11) sejumlah 181 Orang. Sampel dalam penelitian ditentukan dengan menggunakan Rumus Hary King, diperoleh 87 orang. Teknik pengambilan sampel menggunakan Stratification Random Sampling . Analisis data Univariat dan Analisis Bivariat dengan uji statistic Chi Squere (X 2 ). Hasil penelitian menunjukkan bahwa ada hubungan antara pengetahuan tentang Anemia dengan kejadian Anemia pada remaja putri di MA Mathla’ul Anwar Gisting dengan pvalue = 0,002 < α (0,05). Diharapkah remaja memahami bahaya Anemia dengan mencari informasi melalui media berbagai sehingga dapat meningkatkan upaya pencegahan Anemia.
Effects of Different Application Techniques on Nanohybrid Composite Restorations Clinical Success

Dental composites have been used as a restorative material for a long time. However, they have their limitations.This study evaluated the effects of placement techniques on the clinical performance of class I composite resin restorations.A total of 40 patients with split-mouth design participated in this study. Each patient had two fillings according to the placement technique (either bulk or incremental packing) of the composite resin restorations. Group (A): was packed by Tetric EvoCeram bulk-fill composite resin and Group (B): was incrementally packed with Tetric EvoCeram composite resin. Restorations of the teeth were evaluated on the same day, at one week, 3 months and 6 months to determine any signs of failure according to the modified United States Public Health Service (USPHS) criteria.At different follow-up periods, the results showed no significant differences for retention, marginal integrity, surface stain, gingival bleeding, and secondary caries; however, there were significant differences in color match, surface texture, and postoperative sensitivity.This study concluded that the nanohybrid resin composites demonstrated excellent clinical performance for 6 months follow up period.