Miracle-dz/UniFAR-FTUs huggingface dataset:
Autologous peripheral blood stem cell transplantation in patients with relapsed lymphoma results in accelerated haematopoietic reconstitution, improved quality of life and cost reduction compared with bone marrow transplantation: the Hovon 22 study

The present study analysed whether autologous peripheral blood stem cell transplantation (PSCT) improves engraftment, quality of life and cost‐effectiveness when compared with autologous bone marrow transplantation (ABMT). Relapsing progressive lymphoma patients (n = 204; non‐Hodgkin's lymphoma n = 166; Hodgkin's disease n = 38) were, after induction treatment with the DHAP–VIM (cisplatin, cytarabine, dexamethasone, etoposide, ifosfamide, methotrexate) regimen, randomly (2:1) assigned to the harvest of granulocyte–macrophage colony‐stimulating factor‐mobilized stem cells after the second DHAP course or autologous bone marrow cells before the second DHAP course. These stem cells were reinfused following high‐dose myeloblative chemotherapy. After induction, 118 patients obtained a partial or complete response and were eligible for randomization. In the PSCT arm (n = 76) significantly faster engraftment of neutrophils [≥ 0·1 and ≥ 0·5 × 109/l: 10·7 d (7–36, median, range), 15 (9–45) versus 13 (8–25) and 26 (14–80), P < 0·01] and thrombocytes [≥ 20 × 109/l: 13 d (7–51) versus 18 (11–65), P < 0·01] were observed. In addition, significantly fewer transfusions of red blood cells [6 (0–23) versus 8 (2–24), P < 0·01] and platelets [4 (0–60) versus 8 (2–55), P = 0·01] were required in the PSCT arm. These findings were associated with a significant reduction in the median days of intravenous antibiotics in patients with fever [8·5 (0–30) versus 14 (0–34), P = 0·04] and hospital stay [27 (8–51) versus 34 (24–78), P < 0·05]. Quality of life demonstrated a significant difference in favour of the PSCT arm. Total transplantation costs were significantly lower in the PSCT arm [$13 954 ($4913– 29 532) versus $17 668 ($10 170–44 083) P < 0·05], as a result of the reduced hospital stay and lower antibiotic costs. In summary, these results indicate that PSCT is superior to ABMT with regard to engraftment, supportive care, quality of life and cost.
Verificação do desempenho de crianças deficientes auditivas oralizadas em teste de vocabulário

TEMA: vocabulario expressivo de criancas deficientes auditivas oralizadas. OBJETIVO: verificar o desempenho de um grupo de criancas com perda de audicao em um teste de vocabulario expressivo. METODO: o Teste de Linguagem Infantil ABFW - Vocabulario foi aplicado em 21 criancas portadoras de deficiencia auditiva de grau moderadamente severo a profundo divididas em tres grupos, conforme suas idades: 3 anos a 4 anos e 11 meses, 5 anos a 6 anos e 11 meses e 7 anos a 8 anos e 11 meses. Estas criancas utilizavam predominantemente o codigo linguistico oral para se comunicar. RESULTADOS: os individuos pertencentes aos diferentes grupos etarios forneceram mais respostas corretas e processos de substituicao ao nomearem as figuras solicitadas do que nao designaram. Em geral, as criancas com idades entre 7 anos a 8 anos e 11 meses demonstraram melhor desempenho do que aquelas com idades entre 3 anos a 4 anos e 11 meses e 5 anos a 6 anos e 11 meses, cujos comportamentos foram semelhantes. CONCLUSAO: as criancas demonstraram melhores desempenhos nos campos conceituais animais, meios de transporte e formas e cores; as criancas mais velhas mostraram maior conhecimento dos vocabulos na maioria dos campos conceituais. Ao verificar o desempenho destas criancas no Teste de Linguagem Infantil ABFW - Vocabulario, foi possivel concluir que tal verificacao permitiu a identificacao dos campos conceituais em que as criancas possuem maior ou menor dominio, assim como o reconhecimento dos recursos que os sujeitos deficientes auditivos utilizam na tentativa de nomear. Estas informacoes permitem que o fonoaudiologo enfatize os campos conceituais menos conhecidos pelas criancas e abordem os tracos e atributos dos objetos ja conhecidos por elas, antes de apresenta-lo.
Cytokine concentrations in the amniotic fluid during parturition at term: correlation to lower uterine segment values and to labor

Background. In previous studies a significant increase in interleukin (IL)‐6 and IL‐8 concentrations in the lower uterine segment parallel to cervical dilatation at term could be found, however only a weak correlation to duration of labor was detected. This study compares amniotic fluid concentrations of interleukin (IL)‐6 and IL‐8 with those in the lower uterine segment, and the duration of labor.
Detecting Deceptive Opinions: Intra and Cross-Domain Classification Using an Efficient Representation

Online opinions play an important role for customers and companies because of the increasing use they do to make purchase and business decisions. A consequence of that is the growing tendency to post fake reviews in order to change purchase decisions and opinions about products and services. Therefore, it is really important to filter out deceptive comments from the retrieved opinions. In this paper we propose the character n-grams in tokens, an efficient and effective variant of the traditional character n-grams model, which we use to obtain a low dimensionality representation of opinions. A Support Vector Machines classifier was used to evaluate our proposal on available corpora with reviews of hotels, doctors and restaurants. In order to study the performance of our model, we make experiments with intra and cross-domain cases. The aim of the latter experiment is to evaluate our approach in a realistic cross-domain scenario where deceptive opinions are available in a domain but not in another one. After comparing our method with state-of-the-art ones we may conclude that using character n-grams in tokens allows to obtain competitive results with a low dimensionality representation.
Change Management in Adult Educational Organizations: A Slovenian Case Study

Successful implementing and managing of change is urgently necessary for each adult educational organization. During the process, leading of the staff is becoming a key condition and the most significant factor. Beside certain personal traits of the leader, change management demands also certain leadership knowledges, skills, versatilities and behaviour which may even border on changing the organizational culture. The paper finds the significance of certain values and of organizational climate and above all the significance of leadership style which a leader will adjust to the staff and to the circumstances. The author presents a multiple qualitative case study of managing change in three adult educational organizations. The paper finds that factors of successful leading of change exist which represent an adequate approach to leading the staff during the introduction of changes in educational organizations. Its originality/value is in providing information on the important relationship between culture, leadership styles and leader’s behaviour as preconditions for successful implementing and managing of strategic change.
THE CHALLENGES OF ADAPTING TO CLIMATE CHANGE

In its Fourth Synthesis Report published in 2007, the Intergovernmental Panel on Climate Change (IPCC) demonstrated that in spite of efforts to reduce greenhouse gas emissions, certain impacts of climate change will be inevitable. Two types of measures are necessary to confront climate change: mitigation measures and adaptation measures. Mitigation measures will make it possible to limit climate change, while the objective of adaptation measures is to reduce the vulnerability of natural and socio-economic systems and thus to react to climate change at least cost.
The association between depression and thyroid disorders in a regionally representative Canadian sample

A subsample of six provinces (n = 67,621) from the 2005 Canadian Community Health Survey was used to determine the gender-specific prevalence of depression among those with and without thyroid disorders. Information was not available on the type of thyroid disorder. Logistic regression analyses were conducted todetermine the odds and socio-demographic correlates of depression among those with and without thyroid disorders. Women had a significantly higher prevalence of thyroid disorders (9.3%) and depression (6.6%) than men (2.4% and 3.7%, respectively). Thyroid disorders were associated with 22% higher odds of depression in women after adjusting for socio-demographic factors, but no association was found in men. Among women with and without thyroid disorders, younger age, lower income, and limitations in Activities in Daily Living (ADL) were associated with higher odds of depression. Results suggest that women with thyroid disorders are more vulnerable to depression, and socio-demographic correlates of depression are similar among women with and without thyroid disorders.
Indirect Boundary Stabilization of Weakly Coupled Hyperbolic Systems

This work is concerned with the boundary stabilization of an abstract system of two coupled second order evolution equations wherein only one of the equations is stabilized (indirect damping; see, e.g., J. Math. Anal. Appl., 173 (1993), pp. 339--358). We show that, under a condition on the operators of each equation and on the boundary feedback operator, the energy of smooth solutions of this system decays polynomially at $\infty$. We then apply this abstract result to several systems of partial differential equations (wave-wave systems, Kirchhoff--Petrowsky systems, and wave-Petrowsky systems).
Staphylococcus aureus Formyl Peptide Receptor–like 1 Inhibitor (FLIPr) and Its Homologue FLIPr-like Are Potent FcγR Antagonists That Inhibit IgG-Mediated Effector Functions

To evade opsonophagocytosis, Staphylococcus aureus secretes various immunomodulatory molecules that interfere with effective opsonization by complement and/or IgG. Immune-evasion molecules targeting the phagocyte receptors for these opsonins have not been described. In this study, we demonstrate that S. aureus escapes from FcγR-mediated immunity by secreting a potent FcγR antagonist, FLIPr, or its homolog FLIPr-like. Both proteins were previously reported to function as formyl peptide receptor inhibitors. Binding of FLIPr was mainly restricted to FcγRII receptors, whereas FLIPr-like bound to different FcγR subclasses, and both competitively blocked IgG-ligand binding. They fully inhibited FcγR-mediated effector functions, including opsonophagocytosis and subsequent intracellular killing of S. aureus by neutrophils and Ab-dependent cellular cytotoxicity of tumor cells by both neutrophils and NK cells. In vivo, treatment of mice with FLIPr-like prevented the development of an immune complex–mediated FcγR-dependent Arthus reaction. This study reveals a novel immune-escape function for S. aureus–secreted proteins that may lead to the development of new therapeutic agents in FcγR-mediated diseases.
Incidence of HIV‐1 Infection Among Young Men in Thailand

SummaryRoyal Thai Army (RTA) enlistees were tested for HIV-1 seropositivity prospectively in order to explore their feasibility as a cohort in an HIV-1 preventive vaccine efficacy trial. The 17,615 seronegative enlistees, virtually all 21-year-old men, contributed 10,409 person-years (p-y) of follow-up. Cohorts were enlisted in November 1991 and May 1992 from northern Thailand and Bangkok. The follow-up rate was 50%, with loss to follow-up significantly associated with location of the base, marital status, and educational level. Seroincidence was 0.5/100 p-y for recruits stationed in Bangkok, 1.0/100 p-y in the lower north, and 3.2/100 p-y in the upper north. In a multiple regression model, the young man's birthplace was strongly associated with risk of infection, suggesting that transmission occurred during leave as well as during duty. Incidence rates were significantly lower in those who were married at the time of enlistment and in those with 3$$10 years of education. The seroincidence rates among recruits stationed in the upper north support vaccine trial feasibility, but follow-up rates need to be improved.
Cellular phenotype of androgen receptor‐immunoreactive nuclei in the developing and adult rat brain

Androgen exposure during development and adulthood promotes cell‐to‐cell communication, modulates the size of specific brain nuclei, and influences hormone‐dependent behavioral and neuroendocrine functions. Androgen action involves the activation of androgen receptors (AR). To elucidate the mechanisms involved in AR‐mediated effects on forebrain development, double‐label fluorescent immunohistochemistry and confocal microscopy were employed to identify the cellular phenotype of AR‐immunoreactive (AR+) cells in the developing (embryonic day 20, postnatal days 0, 4, 10) and adult male rat forebrain. Sections were doubly labeled with antibodies directed against AR and one of the following: neurons (immature, nestin; mature, NeuN) or astrocytes [immature, vimentin; mature, glial fibrillary acidic protein (GFAP)] or mature oligodendrocytes (mGalC). In all brain regions examined, by far the majority of AR+ cells were neurons. In addition, small subsets of AR+ cells were identified as mature astrocytes (GFAP+) but only in specific brain regions at specific ages. AR+/GFAP+ cells were observed in the cerebral cortex but only in postnatal day 10 rats and in the arcuate nucleus of the hypothalamus but only in adult rats. Immature neurons, immature astrocytes, and oligodendrocytes were not AR+ at any age, in any region. Thus, both neurons and astrocytes in the male rat forebrain contain ARs, suggesting that androgens, via ARs, may exert effects on both cell types in an age‐ and region‐dependent manner. J. Comp. Neurol. 492:456–468, 2005. © 2005 Wiley‐Liss, Inc.
The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma.

PURPOSE LKB1 (also called STK11) is a recently identified tumor suppressor gene in which its mutation can lead to Peutz-Jeghers syndrome, characterized by gastrointestinal polyps and cancers of different organ systems. Weak expression of this gene does occur at a certain frequency in sporadic breast cancer. This indicates that LKB1 gene may relate to the tumorigenesis of breast cancer. EXPERIMENTAL DESIGN To investigate the function of the LKB1 gene in sporadic breast cancer, we reintroduced LKB1 into breast cancer cell lines which lack the LKB1 gene. Also, we examined the LKB1 protein expression in human breast cancer samples. RESULTS We found that reintroducing LKB1 into breast cancer cell lines suppresses cell growth by G(1) cell cycle block. The LKB1-mediated G(1) cell cycle arrest is caused by up-regulation of the expression of p21(WAF1/CIP1) in breast cancer MDA-MB-435 cells. We also demonstrated that low LKB1 protein expression correlates with higher histological grade (P = 0.013), larger tumor size (P = 0.001), progesterone receptor status (P = 0.048), and presence of lymph node metastasis (P = 0.003). Furthermore, LKB1 low expression was associated with a higher relapse rate (P = 0.002) and a worse OS (P = 0.008). CONCLUSIONS LKB1 plays a role in tumor suppressor function in human breast cancer. LKB1 expression may be a useful prognostic marker in human breast cancer.
Toxic Diatom Aldehydes Affect Defence Gene Networks in Sea Urchins

Marine organisms possess a series of cellular strategies to counteract the negative effects of toxic compounds, including the massive reorganization of gene expression networks. Here we report the modulated dose-dependent response of activated genes by diatom polyunsaturated aldehydes (PUAs) in the sea urchin Paracentrotus lividus. PUAs are secondary metabolites deriving from the oxidation of fatty acids, inducing deleterious effects on the reproduction and development of planktonic and benthic organisms that feed on these unicellular algae and with anti-cancer activity. Our previous results showed that PUAs target several genes, implicated in different functional processes in this sea urchin. Using interactomic Ingenuity Pathway Analysis we now show that the genes targeted by PUAs are correlated with four HUB genes, NF-κB, p53, δ-2-catenin and HIF1A, which have not been previously reported for P. lividus. We propose a working model describing hypothetical pathways potentially involved in toxic aldehyde stress response in sea urchins. This represents the first report on gene networks affected by PUAs, opening new perspectives in understanding the cellular mechanisms underlying the response of benthic organisms to diatom exposure.
Digit Sucking in Children Resident in Kettering (UK)

Non-nutritive sucking habits are one of the most important environmental factors affecting a person’s occlusion, particularly when the habit is persistent. Initial sucking habits are described as ‘a daily habit, evident in the small child for several months’ whilst prolonged habits are those ‘which prevail until at least 6 or 7 years of age’. The reported prevalence of initial dummy and finger sucking habits varies between different countries. Scandinavian studies report figures ranging from 70 to 95% of the age groups studied, with dummy suckers being the majority. Before 1970, there was less interest in dummy sucking and hence the prevalence of the initial sucking habits was reported as low, prevalences between 19 and 37% for child groups of different ages and countries (Gardiner: UK, 1956; Klackenberg: Sweden, 1960; Bowden: Australia, 1966). Reports of the prevalence of prolonged digit sucking also vary greatly. Popovich reported a figure of 12.9% among 155 Canadian 10-year-olds and 7.2% of 135 12year-olds. Baalack and Frisk found that 8% of their Swedish sample of 8158, 12-year-olds were prolonged digit suckers at 7 years of age and only 1.9% at 12 years of age. These differences between the Canadian and Swedish study may be due to differing sample sizes and variation in child rearing practices. In a retrospective study of 920 Swedish children, Larsson found that the prevalence of prolonged digit sucking at 9 years of age was 12%. Both the Swedish studies were robust and well designed epidemiological studies with high response rates (80–100%) to their questionnaires. In addition, Larsson’s team interviewed the children and validated the parental responses by telephone, increasing the reliability of their results. There have been relatively few studies of non-nutritive sucking prevalence in the United Kingdom. In 1956, Gardiner interviewed and examined 1000 Sheffield school children aged 5–15 years. The prevalence of an initial digit sucking habit was 27.2%, with 11.2% of the children demonstrating a history of sucking beyond the age of 5 years. The prevalence of an initial dummy sucking habit was 19.5% and less than 3% of these were reported to subsequently develop a digit sucking habit. The prevalence of sucking habits is known to depend on a number of factors including age, sex, race, socioeconomic status and the availability of dummies. There is some evidence that the number of siblings and the mode of feeding have an influence on the prevalence of digit sucking, although this is not conclusive. The aim of the present study was to assess the prevalence of digit sucking amongst primary school children resident in Kettering, and to consider if there were differences between genders, ethnic groups, levels of material deprivation, number of siblings, and association with the use of dummies. This study would provide the basis of a template for investigating digit sucking throughout the United Kingdom.
Comparative Spatial Analysis of a Re-arranged Hospital Building

— Analyzing the relation networks between the hospital buildings which have complex structure and distinctive spatial relationships is quite difficult. The hospital buildings which require specialty in spatial relationship solutions during design and self-innovation through the developing technology should survive and keep giving service even after the disasters such as earthquakes. In this study, a hospital building where the load-bearing system was strengthened because of the insufficient earthquake performance and the construction of an additional building was required to meet the increasing need for space was discussed and a comparative spatial evaluation of the hospital building was made with regard to its status before the change and after the change. For this reason, spatial organizations of the building before change and after the change were analyzed by means of Space Syntax method and the effects of the change on space organization parameters were searched by applying an analytical procedure. Using Depthmap UCL software, Connectivity, Visual Mean Depth, Beta and Visual Integration analyses were conducted. Based on the data obtained after the analyses, it was seen that the relationships between spaces of the building increased after the change and the building has become more explicit and understandable for the occupants. Furthermore, it was determined according to findings of the analysis that the increase in depth causes difficulty in perceiving the spaces and the changes considering this problem generally ease spatial use. study, a public hospital in Sakarya province which is located on an active seismic belt, North East Anatolian Fault Line and Marmara region is discussed. Since the building is insufficient with regard to earthquake, its load-bearing system was modified. Such modifications led to several changes in use of the space. In addition to this reinforcement
Latino AIDS Immigrants in the Western Gulf States

Abstract Immigrant HIV infected Latinos, and those at highest risk for infection, demonstrate strikingly different patterns of risk behaviors and origins. This complicates the already complex acculturation process impacting their lives. By weaving together immigration and AIDS epidemiological patterns, the impact of tightening immigration policy, and masked sexual behaviors, the authors express concern for a lack of communication with, and lack of health care access for, Latinos in the Western Gulf Coast. To combat this deficit, health care and social workers need to be aware of different social, cultural, and behavioral contexts in Latino populations. Policy makers should support efforts to provide health care workers with skills through appropriate language and cultural sensitivity workshops. HIV prevention strategies specific to Latinos are also discussed.
Effectiveness of interventions for convicted DUI offenders in reducing recidivism: a systematic review of the peer-reviewed scientific literature

Abstract Background: Driving under the influence (DUI) is a major cause of death and disability. Although a broad array of programs designed to curb DUI incidents are currently offered to both first-time and recidivist DUI offenders, existing evaluations of the effectiveness of these programs have reported mixed results. Objective: To synthesize the results of DUI program evaluations and determine the strength of the available evidence for reducing recidivism for different types of programs. Methods: A systematic review of all EBSCO databases, EMBASE, PubMed, ProQuest, Sociological Abstracts and TRIS was conducted to identify evaluations of treatments/interventions to prevent DUI offenses. Additional articles were identified from reference lists of relevant articles. Results: A total of 42 relevant studies were identified by the search strategy. Of these, 33 utilized non-experimental evaluation designs or reported insufficient data to allow effect sizes to be calculated, making meta-analysis unfeasible. Evaluations of several different program types reported evidence of some level of effectiveness. Conclusion: Because of the general lack of high quality evidence assessing the effectiveness of DUI prevention programs, it is not possible to make conclusive statements about the types of programs that are likely to be most effective. Nonetheless, there was some evidence to support the effectiveness of programs that utilize intensive supervision and education. There is a need for future evaluations to adopt more scientifically rigorous research designs to establish the effects of these programs.