Miracle-dz/UniFAR-FTUs huggingface dataset:
GIGYF 2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling

Grb10-Interacting GYF Protein 2 (GIGYF2) was initially identified through its interaction with Grb10, an adapter protein that binds activated IGF-I and insulin receptors. The GIGYF2 gene maps to human chromosome 2q37 within a region linked to familial Parkinson’s disease (PARK11 locus), and association of GIGYF2 mutations with Parkinson’s disease has been described in some but not other recent publications. This study investigated the consequences of Gigyf2 gene disruption in mice. Gigyf2 null mice undergo apparently normal embryonic development, but fail to feed and die within the first 2 post-natal days. Heterozygous Gigyf2 mice survive to adulthood with no evident metabolic or growth defects. At 12–15 months of age, the Gigyf2 mice begin to exhibit motor dysfunction manifested as decreased balance time on a rotating horizontal rod. This is associated with histopathological evidence of neurodegeneration and rare intracytoplasmic Lewy body-like inclusions in spinal anterior horn motor neurons. There are a-synuclein positive neuritic plaques in the brainstem and cerebellum, but no abnormalities in the substantia nigra. Primary cultured embryo fibroblasts from Gigyf2 null mice exhibit decreased IGF-I-stimulated IGF-I receptor tyrosine phosphorylation and augmented ERK1/2 phosphorylation. These data provide further evidence for an important role of GIGYF2 in age-related neurodegeneration and IGF pathway signaling.
The Impact of Professional Development on the Delivery of Written Praise and Office Disciplinary Referrals

The Impact of Professional Development on the Delivery of Written Praise and Office Disciplinary Referrals Shalon S. Wilmott Department of Counseling Psychology and Special Education, BYU Educational Specialist in School Psychology The purpose of this research was to examine the impact of professional development on teachers’ delivery of written praise notes and the number of office disciplinary referrals (ODRs). The professional development consisted of training teachers on the effective use of behavior specific written praise, as well as on how to analyze and respond to praise-note and office disciplinary referral data. It was hypothesized that this process could help support and increase teachers’ delivery of behavior-specific written praise notes and would subsequently decrease in the rate of office discipline referrals (ODRs). As baseline data, this study used the participating school’s existing data (November through February for academic years 2009-2010 and 2010-2011). Data included number of praise notes and office disciplinary referrals. Across the most recent school year (November thru February 2011-2012), on a monthly basis, data were collected on number and content of notes and the number of ODRs. Current data were compared with baseline data from two previous school years. Although the data did not indicate significant changes between baseline data and post intervention data, overall data suggest a gradual increase in respect to the number of written praise notes. However, contrary to anticipated outcome, a slight upward trend was indicated in the number of office discipline referrals. These results are considered inconclusive in regard to whether professional development significantly impacts the number and specificity of praise notes and decreases the number of students with ODRs. However, the majority of teachers supported delivering written praise notes as an effective intervention to increase desired classroom academic achievement and appropriate social behavior.
Contextual critical success factors for the implementation of business intelligence & analytics: A qualitative case study

Business intelligence & analytical (BI&A) implementation success depends on the interplay between CSFs-in-context. One persistent criticism of work in IS implementation has been the neglect of exploring implementation CSFs within a multi-layered context. Findings from a case study at a large banking organization in South Africa suggest that an adequate analysis of business intelligence and analytics implementation involves interweaving a CSF analysis with the distinctive features of its multi-layered context. This includes the bank’s intraorganizational context and the IS and BI setting (inner-context) and the broader socioeconomic and political context (outer-context) as domains of analysis. The evidence shows that the actions and interactions of organizational members involved in the BI implementation were being shaped and constrained by the dynamics within these contexts – in particular, coping with complex contextual challenges exerted increasing demands on the implementation team. The ability of the implementation team to overcome these situational demands was at best mixed and the success of the BI implementation therefore varied from unit to unit within the bank. Practitioners should sharpen their problem-solving skills by assessing CSFs within the unique situations they encounter. Future case study research should provide an explicit description and analysis of CSFs-in-context to deepen our understanding of effective BI&A implementations.
THE TERRORISM AND FOREIGN DIRECT INVESTMENT : THE CASE OF PAKISTAN

The purpose of the study is to investigate the affects of terrorism on foreign direct investment (FDI) inflows in Pakistan. Time-Series data from 2000 to 2015 has been taken for the variables. This research considers log value of FDI and terrorism data for analysis. It focuses on Correlation analysis and Ordinary Least Square (OLS) techniques used to examine the relationship and its intensity between the FDI inflows and Terrorism. The tests determine negative association between the dependent variable FDI inflows and independent variable Terrorism. It means terrorism put adverse affect and become a cause of variation in foreign direct investment in Pakistan.
Calculation of Garnet Fractionation in Metamorphic Rocks , with Application to a Flat-Top , Y-rich Garnet Population from the Ruhla Crystalline Complex , Central Germany

A mathematical approach is presented for the calculation of the major and trace element fractionation that is caused by growth of zoned garnet in metamorphic rocks. This approach is based on textural and compositional parameters directly obtained from natural examples. It takes into account the mode and composition of all unzoned minerals, as well as the mode, crystal size distribution and zonation patterns of garnet grains of different sizes within a certain rock volume. These parameters can be used to fit functions from which the amount of garnet fractionation at each step of a garnet growth history can be calculated. The approach is tested for two compositionally distinct domains within a single garnet–biotite gneiss sample from the Ruhla Crystalline Complex. This sample contains unusual flat-top garnet grains with Y2O3-rich cores. It is shown that MnO, FeO and Y2O3 are extremely fractionated during garnet growth, but in different ways, and that MnO fractionation does not obey a Rayleigh function. To demonstrate the influence of garnet fractionation on P–T path estimates, quantitative phase diagrams in the model system Na2O– K2O–CaO–MnO–FeO–MgO–Al2O3–TiO2–SiO2–H2O are constructed by means of the computer software THERMOCALC. The good agreement between calculated and observed mineral assemblages and garnet compositions for all fractionation steps indicates that the new approach can be used to infer detailed P–T paths, even for rocks that contain complexly zoned garnet grains. The results indicate that garnet growth in the metapelite under investigation occurred along a linear P–T path from 470 C and 2.7 kbar to 580 C and 8.5 kbar. The results also show that garnet cores with high Y2O3 contents of about 1 wt % nucleated over a temperature interval of c. 90 C, indicating that Y in garnet is relatively insensitive to temperature changes.
On the Return Predictability of Investor Sentiment : Time-series and Cross-sectional Evidence from China

This paper challenges the prevailing view that investor sentiment is a contrarian predictor of market returns at nearly all horizons. By providing an important piece of "out-of-sample" evidence, we document that investor sentiment in China is a reliable momentum predictor for equity returns at monthly frequency. The strong near-term return predictability is robust under both singleand multi-regressor settings, and is statistically and economically significant both in and out of sample, indicating enhanced portfolio performance as shown by our numerical example. More importantly, we document a striking pattern that local sentiment shifts from a momentum predictor in near and intermediate term to a contrarian predictor in the long term. In contrast to local sentiment, global sentiment remains a contrarian predictor over various return horizons, confirming the spillover of sentiment across markets. Further cross-sectional analysis suggests that local sentiment influences more on small-sized stocks than large-sized stocks, while global sentiment has less impact on small stocks, especially in the short run. JEL classification: C22; C53; G11; G12; G17
Explorer Multitask Gaussian Process Prediction

In this paper we investigate multi-task learning in the context of Gaussian Processes (GP). We propose a model that learns a shared covariance function on input-dependent features and a “free-form” covariance matrix over tasks. This allows for good flexibility when modelling inter-task dependencies while avoiding the need for large amounts of data for training. We show that under the assumption of noise-free observations and a block design, predictions for a given task only depend on its target values and therefore a cancellation of inter-task transfer occurs. We evaluate the benefits of our model on two practical applications: a compiler performance prediction problem and an exam score prediction task. Additionally, we make use of GP approximations and properties of our model in order to provide scalability to large data sets.
Electronic delay detonators-benefits and growth prospects in India

Since the invention of Gunpowder in 1860 by Alfred Nobel mining industry was in need of initiating devices which helps in increasing blast size, improve safety during charging & blasting operation, as well as explosive performance. From Plain detonators & Safety fuse system to Shock-tube initiation system, commercial basting has made helped the above cause, however each system has some limitation in terms of accuracy of delay, safety requirement as well as complexity required in terms blast requirement of modern mining industry. Electronic Delay Detonators have came long way since their invention in late 90s. They have helped Blasting Engineers in solving modern mining requirement of Large blast with minimum Vibration, Better control on fragmentation, Blasting multi layer rock together, controlling throw & back break etc. Electronic Delay Detonators have been introduced in the Indian market in last 7-8 years mainly for Vibration controls. With increase knowledge Indian mining industry is now ready to embrace the other technological benefits of Electronic detonators. The papers make an attempt to highlight the benefits associated with use of Electronic detonators & future growth prospects of the same in Indian Mining & Construction industry. Keywords—Electronic detonator; blasting; ground vibration.
Uncertainties Surrounding Natural Rate Estimates in the G 7 Rod Cross University of Strathclyde and ICMM

This paper discusses some of the uncertainties surrounding natural rates of unemployment. Point estimates of the natural rate are usually generated as ratios between parameters estimated in regression equations. Thus uncertainties about the estimated parameter values inevitably implies uncertainty about the natural rate of unemployment. Regression packages do not usually report standard errors for non-linear functions of parameters, so standard errors for natural rate estimates are not usually reported. Staiger, Stock and Watson and others have corrected this deficiency by estimating confidence intervals for natural rates in the US. The present paper extends this work to the G7 countries and finds that although a careful specification search yields an improvement in the precision of estimates of the natural rate, there is still a large degree of uncertainty. JEL Classification: E31, C52, E24. We are grateful to Bob Hart, Jim Malley, Anton Muscatelli and participants at the CEPR/ESRC Workshop on Unemployment Dynamics, London, May 1997 and the Warwick Macroeconomic Modelling Bureau Conference July 1997 for useful comments and discussions. Darby and Ireland acknowledge ESRC funding under grant number L116251026.
THE REFLECTIONS OF ORGANIZATIONAL IDENTIFICATION BUILT UPON SOCIAL IDENTITY THEORY ON THE PERCEPTION OF ALIENATION IN HIGHER EDUCATION

From the social perspective of higher education, the effect of organizational identification on undergraduate students gains importance in order to explain their perceptions of alienation. The aim of this study is to investigate and to quantify the relationship between the organizational identification built upon social identity theory and the perception of alienation in higher education. This study was hypothesized that Organizational Identification including the two categorical antecedents; namely, organizational distinctiveness and organizational prestige influences the undergraduate students’ perception of alienation in higher education. The study group here used was selected from university students studying at a prestigious state university in Istanbul, Turkey in the 2015-2016 Academic Year. The scales of Organizational Identification, Organizational Distinctiveness, Organizational Prestige, and Alienation were applied to 201 university students. The SPSS 22.0 (Statistical Package for Social Sciences) was used for analyzing the data obtained from the participants from the university. Independent-sample t-tests and the one-way analysis of variance (ANOVA) were used to determine whether there are any significant differences among the means of independent groups. In order to determine whether or not there has been any relationship between organizational identification and the undergraduate students’ perception of alienation, correlation analysis was performed; and to quantify this relationship Multiple Linear Regression analysis was performed. The results of this study suggested that there was a significant effect of gender on alienation, with women receiving higher scores than men. For the demographic variable "age", there was a significant difference between age groups for organizational identification, organizational distinctiveness, and organizational prestige respectively, with the ones aged between 17-19. Additionally, school type was revealed to have a significant effect on the perceived organizational identification and alienation. For the demographic variable " the order of preference in the university application ", the results suggested that there was no significant difference between participants’ order of preference in the university application and factors. It was also found out that organizational identification has a positive effect while organizational distinctiveness has a negative effect on alienation. Moreover, being Science High school graduates and female increased the alienation score. Finally, the scores of organizational identification predicted alienation through a positive correlation, but the scores of organizational distinctiveness predicted alienation through a negative correlation.
Strategic Abstention in Proportional Representation Systems (Evidence from Multiple Countries)

This paper proposes a framework to assess whether there is strategic abstention in proportional representation (PR) systems. Strategic abstention occurs when instrumental voters who believe the race is extremely close choose to abstain. Drawing from Blais (2006), the assumption is that the race between coalitions (and not between parties) is what ultimately matters. The main predictions are two: (i) voters who expect the race to be neck-and-neck are more likely to abstain when they cannot express a strong preference for any of the two leading coalitions; and (ii) preferences over coalitions no longer explains turnout among voters who believe one of the coalitions is clearly ahead. In order to test them, I use pre-electoral survey data from five different elections in three different countries (Austria, Germany, and Israel). Results strongly support both predictions. Finally, this paper also shows that uncertainty regarding which coalitions may be formed decreases turnout. Taken together, these results suggest that, in PR systems, coalition expectations play a key role in the decision to vote or not.
11A.4 AN ANALYSIS OF DEEP CONVECTION INITIATION ENVIRONMENTS

Fundamentally, deep convection initiation (DCI) requires that a volume of air be lifted to a level where it is able to realize considerable positive buoyancy over a significant depth. Positive area on a thermodynamic diagram for some lifted parcel is a necessary condition; however, the effects of dilution on the buoyancy that an actual updraft is able to realize cannot be neglected (Houston and Niyogi 2007; hereafter HN07). Also, the amount of lift that is needed depends on the amount of inhibition present below the level of free convection (LFC). These ideas are captured by the three “ingredients” of Johns and Doswell (1992) – instability, moisture, and lift. Consideration of the processes that govern convection suggests a slight modification to that approach in which DCI is examined in the context of two pairs of factors – buoyancy and dilution, and lift and inhibition. The “moist layer of sufficient depth” (Johns and Doswell 1992) has two roles. The first is to produce a parcel with sufficient θe to achieve positive buoyancy given the temperature profile and the assumptions of parcel theory. The second role (and primary reason the depth of the moisture is important) is to limit the dilution of the parcel as it ascends. Therefore, we contend that it is better to consider buoyancy and dilution as the governing factors. Furthermore, HN07 showed that a positive feedback exists between dilution and buoyancy. Lift and inhibition are paired since the amount of inhibition is what determines if a given amount of lift is sufficient to initiate a thunderstorm. Buoyancy and inhibition are frequently assessed using parameters based on parcel theory, in particular convective available potential energy (CAPE; Moncrieff and Miller 1976) and convective inhibition (CIN). However, the collocation of significant CAPE and
Effect of Relational Benefits , Satisfaction and Customer Loyalty in Culinary Services Industry in Makassar

Provide a consistent basis to the customer satisfaction can make customers become loyal to Culinary Services Industry in Makassar. Customer Loyalty attitude to Culinary Services Industry in Makassar will be very helpful in the restaurant business and a restaurant in the culinary service industry to be able to survive in a competitive business because the customers are the source of income of culinary services industry in the city of Makassar. Relationship marketing is a marketing strategy that can be used to achieve these goals. Through a strategy of relational benefits, culinary services industry in the city of Makassar to provide benefits on the relationship between food and the customer service industry. This research was conducted by the city of Makassar culinary services industry by respondents as many as 153 people. The results showed that confidence benefits and social benefits and significant positive effect on customer satisfaction and loyalty in culinary services in the city of Makassar. Special treatment benefits no significant effect on customer satisfaction and loyalty in the industry culinary services in the city of Makassar Furthermore, customer satisfaction and significant positive effect on the Customer Loyalty culinary Services Industry in the city of Makassar.
Prevalence and risk factors for diabetic foot ulcer among diabetes patients attending the medical clinic in Teaching Hospital

Diabetic foot ulcer (DFU) is one of the most significant complications of diabetes and is associated with multiple risk factors. The development of DFU increases risk of developing foot infections, prolonged healing time, poor quality of life, gangrene, and lower limb non traumatic amputations. Studies have been conducted to identify the factors associated with DFU to determine what strategies can be implemented to prevent DFU leading to amputations and other complications. The aim of this study is to assess the prevalence and associated risk factors for DFU among diabetes patient who are attending to medical clinic in Teaching Hospital Batticaloa. A cross sectional descriptive study was conducted on diabetes patients attending to medical clinic in THB. An Interviewer administered questionnaire was used to assess the prevalence and risk factors for DFU. All the diabetes patients attending to medical clinic on October 2016 were selected. Weight and height were measured using appropriate measuring scales. Out of 248 diabetic patients’ prevalence of DFU was 22.2%, and 58.2% (n=32) of diabetes patients with foot ulcer were females and according to result of the study DFU more common among the age group of 55-64 years (47.3%). Findings suggest that DFU is increasing the health problems among diabetes patients. The results indicate that glycemic control, amputation, renal disease, visual problems after diabetes, moisturizing of foot were significantly associated with DFU. The findings of this study may widen the awareness of healthcare professionals as well as diabetes patient over the DFU care and prevention of diabetes patients and guide them to find out solution to prevent DFU leading to amputations and other complications.
The Effects of Speech Impairment on Quality of Life over Time in Patients with Amyotrophic Lateral Sclerosis

Limited research exists on how speech impairments affect quality of life (QOL) factors over time in patients with amyotrophic lateral sclerosis (ALS). A review of the literature, including the history, disease course, and prevalence of ALS, is presented. Physical and psychosocial functioning, especially the decline of bulbar functioning’s potential impact on QOL factors and communication style, are outlined. This study is a follow-up study on a study by Duff, who found a significant difference in QOL relative to level of bulbar functioning in a cross-sectional design. The current study used a longitudinal design to look at bulbar functioning, specifically levels of speech, and how that affects certain aspects of QOL over time. This study used archival data, collected from a multidisciplinary clinic at three time points, and evaluated the following measures: ALS Functional Rating Scale–Revised (ALSFRS–R) and the ALS–Specific Quality of Life Measurement–Revised (ALSSQOL–R). ALSSQOL–R domains of Negative Emotion, Interaction with People and the Environment, Intimacy, and Bulbar Function were analyzed by repeated measures tests, and correlated to speech impairment over time. Results indicated that as speech became significantly more impaired, no significant differences were observed on the Negative Emotion, Interaction with People and the Environment, and Intimacy subscales. However, as the ability to speak declines over time, participants’ Bulbar Functioning subscale scores decreased. These findings suggest that increased bulbar symptoms are perceived as more problematic over time point. However, results also indicated that at the third time point (most recent clinic visit) the relationship between actual speech impairment and perceived bulbar functioning weakens.