Miracle-dz/UniFAR-FTUs huggingface dataset:
Setting SNAREs in a Different Wood

Vesicle traffic is essential for cell homeostasis, growth and development in plants, as it is in other eukaryotes, and is facilitated by a superfamily of proteins known as soluble N‐ethylmaleimide‐sensitive fusion protein attachment protein receptors (SNAREs). Although SNAREs are well‐conserved across phylla, genomic analysis for two model angiosperm species available to date, rice and Arabidopsis, highlights common patterns of divergence from other eukaryotes. These patterns are associated with the expansion of some gene subfamilies of SNAREs, the absence of others and the appearance of new proteins that show no significant homologies to SNAREs of mammals, yeast or Drosophila. Recent findings indicate that the functions of these plant SNAREs also extend beyond the conventional ‘housekeeping’ activities associated with vesicle trafficking. A number of SNAREs have been implicated in environmental responses as diverse as stomata movements and gravisensing as well as sensitivity to salt and drought. These proteins are essential for signal transduction and response and, in most cases, appear also to maintain additional roles in membrane trafficking. One common theme to this added functionality lies in control of non‐SNARE proteins, notably ion channels. Other examples include interactions between the SNAREs and scaffolding or other structural components within the plant cell.
Planar millimeter-wave antenna on low-cost flexible PET substrate for 5G applications

This paper introduces a millimeter-wave (MMW) high bandwidth antenna on low-cost flexible PET substrate for future 5G wireless networks. The antenna design consists of a rectangular patch structure having symmetrical arrangements of slots on both sides of patch. The antenna consists of a coplanar waveguide (CPW) feed with a rectangular aperture in the ground plane. The proposed antenna shows a high bandwidth of 22GHz-40GHz, which covers the Ka band (26.5-40GHz) of electromagnetic (EM) spectrum. The peak gain of antenna is 8.2dBi at 38.75GHz and the gain is above 4dBi in the complete range of operation. Antenna is well suited for future 5G wireless networks with the flexibility to incorporate on planar surfaces like windows, doors etc. or can be made a part of non-planar surfaces like uniform or casual clothing.
The Enhancement of Female Sexual Function with ArginMax, a Nutritional Supplement, Among Women Differing in Menopausal Status

We conducted a double-blind, placebo-controlled study to determine the role of dietary supplementation on sexual function in women of differing menopausal status. One hundred eight (108) women, age 22–73 years, who reported a lack of sexual desire, enrolled as participants. Of these, 55 received ArginMax for women and 53 received placebo. ArginMax for women contains L-arginine, ginseng, ginkgo, damiana, multivitamins, and minerals. The 108 women, given definitions, self-reported as 59 premenopausal (PRE); 20 perimenopausal (PERI), and 29 postmenopausal (POST). After 4 weeks, PRE women on ArginMax primarily reported significant improvement in level of sexual desire (72%; p = 0.03) and satisfaction with overall sex life (68%; p = 0.007), compared with placebo group, according to the Female Sexual Function Index (FSFI; Kaplan et al., 1999) scales. Frequency of sexual desire (60%; p = 0.05) and frequency of intercourse (56% p = 0.01) also increased among the PRE women. In contrast, among PERI women, primary improvements were reported for frequency of intercourse (86%; p = 0.002), satisfaction with sexual relationship (79%; p = 0.03), and vaginal dryness (64%; p = 0.03) compared with placebo group. POST women primarily showed an increased in level of sexual desire, with 51% showing improvement, compared with only 8% in the placebo group (p = 0.008). Nutritional intervention plays an important role in women's sexual health, but issues and areas of greatest improvement differ among women of different menopausal states. The largest number of attribute improvements were seen in PRE and PERI women, although attribute types vary among these groups. Level of desire was shown to increase significantly in POST women. Since ArginMax for women has been shown to exhibit no estrogen activity, it may be desirable alternative to hormone therapy for sexual concerns.
Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS)

Abstract The current study was aimed (1) to study the green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract, (2) to investigate the induction of apoptosis by biologically synthesized silver nanoparticles in gastric cancer cell line (AGS) and (3) to compare their anti-cancer potential with commercial silver nanoparticles. The specification and morphology of the phytosynthesized AgNPs were evaluated using transmission electron microscopy (TEM), scanning electron microscopy (SEM), UV–visible spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy (FTIR). The nanoparticles synthesized were of an average size of 22 nm. The cytotoxicity of biological and commercial nanoparticles was investigated in gastric cancer cells (AGS) as well as normal fibroblast cells (L–929) by MTT assay. By increasing the concentration of phytosynthesized and commercial silver nanoparticles, a decrease was observed in the cell viability. Increased apoptosis was observed in the cells treated with biological silver nanoparticles compared to untreated cells (p < .001). Based on these findings, it was inferred that biologically synthesized silver nanoparticles induced apoptosis, and showed a cytotoxic and anti-cancer effect against gastric cancer cell lines in a dose- and time-dependent manner. Biologically synthesized nanoparticles may possess higher anti-cancer properties than commercial silver nanoparticles.
CrowdBC: A Blockchain-Based Decentralized Framework for Crowdsourcing

Crowdsourcing systems which utilize the human intelligence to solve complex tasks have gained considerable interest and adoption in recent years. However, the majority of existing crowdsourcing systems rely on central servers, which are subject to the weaknesses of traditional trust-based model, such as single point of failure. They are also vulnerable to distributed denial of service (DDoS) and Sybil attacks due to malicious users involvement. In addition, high service fees from the crowdsourcing platform may hinder the development of crowdsourcing. How to address these potential issues has both research and substantial value. In this paper, we conceptualize a blockchain-based decentralized framework for crowdsourcing named CrowdBC, in which a requester's task can be solved by a crowd of workers without relying on any third trusted institution, users’ privacy can be guaranteed and only low transaction fees are required. In particular, we introduce the architecture of our proposed framework, based on which we give a concrete scheme. We further implement a software prototype on Ethereum public test network with real-world dataset. Experiment results show the feasibility, usability, and scalability of our proposed crowdsourcing system.
Changes in Wage Inequality in the Czech Republic : New Evidence Using Linked Employer-Employee Dataset *

In this paper, we look at the evolution of the change in the wage structure using a linked employer-employee dataset covering a large fraction of the Czech labor market over the period 1998-2006. We find evidence of slightly diminishing gender inequality and increasing returns to human capital. Moreover, exploiting the linked employer-employee character of the data set, we document changes in within-firm wage dispersion and between-firm dispersion. We investigate various hypotheses: increased domestic and international competition, an increasingly decentralized wage bargaining, and a changing educational composition of the workforce to explain these patterns. We find some support that all these factors have contributed to the changes in the Czech wage structure, although the latter is the most strongly associated with the observed changes in wage inequality. * We would like to thank Pavel Mrazek and Vladimir Smolka from Trexima for valuable advice and helpful assistance with the data. Comments from numerous participants on earlier versions presented at conferences in Xiamen (2007), Brussels (LEED), Warsaw (IAES), New York (SOLE, 2008) , Budapest (CAED), Ostrava and Karvina, are gratefully acknowledged.
Ca 2 + stores regulate ryanodine receptor Ca 2 + release channels via luminal and cytosolic Ca 2 + sites

1. In muscle, intracellular calcium concentration, hence sk eletal muscle force and cardiac output, is re gulated by uptake and release of calcium from the sarcoplasmic reticulum. The ryanodine receptor (RyR) forms the calcium release channel in the sarcoplasmic reticulum. 2. The free [Ca2+] in the sarcoplasmic reticulum regulates the excitability of this store by stimulating the Ca2+ release channels in its membrane. This process involves Ca2+ sensing mechanisms on both the luminal and cytoplasmic side of the RyR. In the cardiac RyR these ha v been shown to be: a luminal Ca 2+-activation site (L-site, 60 μM affinity), a cytoplasmic acti vation site (A-site, 0.9μM affinity) and a cytoplasmic Ca2+-inactivation site (I2-site, 1.2μM affinity). 3. Cardiac RyR acti vation by luminal Ca2+ occurs by a multi-step process dubbed “luminal-triggered Ca 2+ feedthrough”. Ca2+ binding to theL-site initiates brief (1 ms) openings at a rate of up to 10 per second. Once the pore is open, luminal Ca 2+ has access to the A-site (producing up to 30-fold prolongation of openings) and to the I2-site (causing inactivation at high levels of Ca2+ feed-through). 4. Reviewed here are: the evidence for the principal aspects of the “luminal-triggered Ca 2+ feed-through” model, the properties of the various Ca 2+-dependent g ating mechanisms and their lik ely role in controlling SR Ca 2+
Does brain white matter growth expand the cortex like a balloon? Hypothesis and consequences

Horrobin (2001) has proposed that phospholipid metabolism is linked to human brain growth, and that deviations in the metabolism may be linked to creativity as well as mental disorders. The present literature review leads to a framework or model which states that brain white matter growth causes the overlying cortex to expand tangentially, like a balloon, and that this expansion affects the cortex's capacity to differentiate afferent signals. The neuro anatomical description of this model is based on publications linking human white matter growth and mass to the thickness of the overlying cortex, and of some linking cortical thickness and surface area (inversely). The link between the surface area of a cortical region and its differentiation capacity is based on previous work on hemispheric differences and functional lateralisation in the human auditory cortices. The link between differentiation capacity and inappropriate responses or “loose associations” is based on publications linking perceptual deficits and abnormal cortical structure, especially abnormal laterality. Finally, perceptual deficits have been linked to aspects of schizophrenia or other “disorders”.
Increases in Thyroid Cancer Incidence and Mortality-Reply.

stimulus for stalled late-stage development. The assessments of novelty used in this analysis were based on publicly available information and may differ from the FDA’s determination. Companies may not have responded to the voucher incentive because its value is uncertain: the value decreases as more vouchers become available on the market.5 Since 2007, Congress has expanded the number of voucher programs so that vouchers can now also be awarded for new treatments for rare pediatric diseases and medical countermeasures. An improved incentive scheme would reduce the risk of neglected tropical disease product development such as by decreasing the cost of clinical trials to pharmaceutical companies. A publicprivate partnership could provide financial support to sponsors of neglected tropical disease products. The partnership could be actively managed to ensure reasonable cost and access to the end product, unlike the priority review voucher, which does not require companies to make products widely available to patients.
Clinical , MRI , and Arthroscopic Correlation in Meniscal and Anterior Cruciate Ligament Injuries

The aim of this prospective study is to compare and correlate clinical, magnetic resonance imaging (MRI), and arthroscopic findings in cases of meniscal tear and anterior cruciate ligament (ACL) injuries. MRI scan results and clinical diagnosis are compared against the arthroscopic confirmation of the diagnosis. Twenty-five patients had suspected traumatic meniscal or anterior cruciate ligament (ACL) injury. Clinical examination had better sensitivity (85.71% vs. 77.78%), predictive values, and diagnostic accuracy (92% vs. 90%) in comparison to MRI scan in diagnosis for medial meniscal tears. These parameters showed only marginal difference in lateral meniscal and anterior cruciate ligament injuries. We conclude that carefully performed clinical examination can give equal or better diagnosis of meniscal and ACL injuries in comparison to MRI scan. MRI may be used to rule out such injuries rather than to diagnose them.
Exploration of the Arrest Peptide Sequence Space Reveals Arrest-enhanced Variants*

Background: The stalling efficiency of translational arrest peptides (APs) is sensitive to mechanical pulling forces on the nascent chain. Results: We identify new APs with enhanced stalling efficiency. Conclusion: Mechanical pulling forces reduce stalling induced by diproline stretches in efp− cells. Significance: Our results provide new insights into AP-induced translational stalling and offer new in vivo force sensors. Translational arrest peptides (APs) are short stretches of polypeptides that induce translational stalling when synthesized on a ribosome. Mechanical pulling forces acting on the nascent chain can weaken or even abolish stalling. APs can therefore be used as in vivo force sensors, making it possible to measure the forces that act on a nascent chain during translation with single-residue resolution. It is also possible to score the relative strengths of APs by subjecting them to a given pulling force and ranking them according to stalling efficiency. Using the latter approach, we now report an extensive mutagenesis scan of a strong mutant variant of the Mannheimia succiniciproducens SecM AP and identify mutations that further increase the stalling efficiency. Combining three such mutations, we designed an AP that withstands the strongest pulling force we are able to generate at present. We further show that diproline stretches in a nascent protein act as very strong APs when translation is carried out in the absence of elongation factor P. Our findings highlight critical residues in APs, show that certain amino acid sequences induce very strong translational arrest and provide a toolbox of APs of varying strengths that can be used for in vivo force measurements.
PEDESTRIAN ACCIDENTS AND INJURIES IN TRIPOLI CITY-LIBYA

@o÷ÐUa@ÝO"m@baaii ‹aEUa 60-16 oja@ea %36.4 t†ai¨a@as @L @oab×@baaii ojaUa %10 OiI@oi‹aEUa@o÷ÐUU 60 ea @N @a@'biO¾@bOj e (AIS 4-6) � aebI %34.1 ABSTRACT Pedestrians in Libya are the more risk group of road users; the present study was intended to study the general characteristics of 442 pedestrians struck by vehicles on Libyan road in 2003 and 2004. Accidents were described in terms of vehicles involved, age and sex of the casualties, the location of impact, and the overall severity of injuries sustained. The pedestrian details were collected from the Accidents hospital in Tripoli. The statistical method of the chi-square test is used to identify whether a significant relationship exists between two categorical variables. The most vulnerable age groups were children at age less than 15 years who accounted for 53.5%, of all accidents while 49% of pedestrian's death was children, Adult aged 16-60 years accounted for 36.4% and elderly adults aged more than 60 years accounted for 10%. Life threatening or fatal injuries (AIS 4-6) were sustained by 34.1% of the children, 17.5% of adults and 38.7% of the elderly adults. Head injuries were the commonest form of injury for all age group closely followed by limb fractures.
A new protection scheme for DC microgrid using line current derivative

Protection scheme for AC transmission systems are well understood and matured. On the other hand, DC system is still facing a challenge in developing proper protection scheme because of its natural characteristics. A protection scheme, which utilizes some of the developed techniques for AC system, and modified to suit the DC system characteristics, is proposed in this paper. The scheme is based on the concept of DC current profile under transients, which depends on the fault location. This property is combined with the directional feature to achieve the protection of a DC microgrid. The proposed scheme is demonstrated on the ring type DC microgrid system, which is able to detect the fault in the DC system, and also ensure its backup protection. The proposed concept is verified and tested through MATLAB/Simulink simulations.
The use of complementary and alternative medicine therapies in type 2 diabetic patients in Mexico.

The growing utilization of complementary and alternative medicine (CAM) therapies represents one of the characteristic phenomena facing scientific medicine. Studies of the patient’s opinions and attitudes toward CAM therapies are scarce. Among doctors, it is widely considered that the use of CAM therapies is only linked to a particular social or cultural background. We undertook a cross-sectional study designed to evaluate the spontaneous use of CAM therapies among 573 type 2 diabetic patients (aged 51.9 ± 10 years) in nine family medicine clinics in Mexico City, using a questionnaire form. Almost 62% (353) of participants make use of CAM therapies, a higher percentage than that reported in the U.S. (8%) and Canada (37.3%). Our patients were younger, more likely …
A model for the effects of job insecurity on performance, turnover intention, and absenteeism

This study investigates the effects of job insecurity on four organizationally important outcomes: in-role behaviour, organizational citizenship behaviour, turnover intention, and absenteeism. A model is tested in which job insecurity is simultaneously a hindrance and a challenge stressor. In particular, job insecurity is proposed to have a predominantly harmful effect on performance, turnover intention, and absenteeism, and it is argued that these effects are mediated by (reduced) work attitudes. In addition, job insecurity is also assumed to affect these behaviours in the opposite way (i.e. a suppressor effect) because job insecurity might motivate employees to make themselves more valuable to the organization by working harder and being less absent. The model is tested with a sample of 136 German non-managerial employees. Data from supervisors (i.e. in-role behaviour and organizational citizenship behaviour), the company's personnel files (i.e. absenteeism), and self-reports (i.e. job insecurity, work attitudes, turnover intention, in-role behaviour, and organizational citizenship behaviour) were used. Structural equation modelling showed that a model that included both negative and positive effects fitted the data best. The negative effect was stronger than the positive effect. The results show that the effects of job insecurity are more complex than previously assumed. In addition, the results also extend previous research into hindrance and challenge stressors because they show that stressors should not be categorized as either hindrance or challenge. Instead, it might be more appropriate to conceptualize hindrance and challenge as two dimensions.
Incidence Density of Invasive Fungal Infections during Primary Antifungal Prophylaxis in Newly Diagnosed Acute Myeloid Leukemia Patients in a Tertiary Cancer Center, 2009 to 2011

ABSTRACT Although primary antifungal prophylaxis (PAP) is routinely administered in patients with acute myeloid leukemia (AML) during remission-induction and consolidation chemotherapy, the impact of PAP on the incidence of invasive fungal infections (IFIs) is not well described. We retrospectively analyzed the incidence of IFIs in 152 patients with AML who had been admitted to a tertiary cancer center between August 2009 and March 2011 and received PAP within 120 days after first remission-induction chemotherapy. We excluded patients who had undergone stem cell transplantation. Patients received a PAP drug with anti-Aspergillus activity during 72% (7,660/10,572) of prophylaxis-days. The incidence of documented IFIs (definite or probable according to revised European Organization for Research and Treatment of Cancer [EORTC] criteria) was 2.0/1,000 prophylaxis-days (95% confidence interval [CI], 1.23 to 3.04). IFIs due to molds were more common than IFIs due to yeasts (1.5/1,000 prophylaxis-days versus 0.4/1,000 prophylaxis-days; P = 0.01). Echinocandin-based PAP (8.6 and 7.1/1,000 prophylaxis-days, respectively) was associated with higher rates of documented IFIs than anti-Aspergillus azoles (voriconazole or posaconazole) (2.4 and 1.1/1,000 prophylaxis-days, respectively) at both 42 days (P = 0.03) and 120 days (P < 0.0001) after first remission-induction chemotherapy. The incidence of overall (documented and presumed) IFIs (P < 0.001), documented IFIs (P < 0.01), and empirical antifungal therapies (P < 0.0001) was higher during the first 42 days than after day 42. Despite the broad use of PAP with anti-Aspergillus activity, IFIs, especially molds, remain a significant cause of morbidity and mortality in AML patients, predominantly during the remission-induction phase. Patients receiving echinocandin-based PAP experienced higher rates of IFIs than did those receiving anti-Aspergillus azoles.
Etude systématique des positions et de la stabilité des structures tourbillonnaires au-dessus d'ailes ogives et de cônes

L’etude concerne la determination des positions relatives des tourbillons au-dessus, d'une part d'ailes a bords d'attaque en forme d'arc de cercle (ailes dites ogivales), et d'autre part de cones, en vue de l'application des criteres angulaires de stabilite des systemes tourbillonnaires. Cette etude a ete realisee a partir de nombreuses visualisations effectuees en soufflerie, ces dernieres ont permis d'observer les differents angles privilegies que peuvent faire entre eux les tourbillons rectilignes au-dessus des ailes delta, des ailes ogives et des cones. Le but de cette etude est d'apporter une contribution a l'optimisation des formes marines, aeriennes et terrestres telles que les voiles, les ailes d'avions, les voitures, les trains, optimisation liee a la stabilite de l'ecoulement des fluides autour de ces formes.