Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of MicroRNA-155 in Human Breast Cancer

MicroRNA-155 is often upregulated in various types of malignancy, including breast cancer. However, the clinical and pathological significance of deregulation of miR-155 remain elusive in breast cancer. Here, we evaluated miR-155 expression in 154 primary breast cancers and 69 normal mammry tissues. Increase levels of miR-155 were oberserved in 67 (43.5%) patients with breast cancer as compared to normal tissue controls. Elevated miR-155 is associated with high grade (49/76, 64.5% versus low grad 18/78, 23.1%) and late stage (37/70, 52.9% versus early stage 30/84, 35.7%) of tumors as well as invasive (53/85, 62.4% versus non-invasive 14/69, 20.3%) breast carcinoma. More significantly, miR-155 is frequently overexpressed in lymph node-positive tumor (i.e., ≥ 10; 20/32, 62.5%) than node-negative (i.e., < 10; 47/122, 38.2%). MiR-155 levels do not correlate to ER, PR, and Her2/neu expression. Furthermore, patients whose tumors express high levels of miR-155 have shorter overall survival than those of tumors with low levels of miR-155. These findings indicate that miR-155 is unfavorable prognostic marker and could be a critical target for triple-negative breast cancer while the molecular mechanism needs to be further investigated.
Changes in Some Red Cell Enzymes, Coagulation and White Cell Parameters in Relation to CD4 Count Values in HIV Subjects

Aim: To assess the effect of CD4 count stage of HIV positive patients on antiretroviral treatment (ART) and those not on antiretroviral treatments on G-6-PD, Pyruvate kinase enzyme activity, some coagulation and white cell parameters. Study Design: Case-control study Place of Study: Nnamdi Azikiwe University Teaching Hospital Nnewi, Nigeria. Methodology: We included 181 subjects; Sixty HIV patients on ART; Sixty HIV patients not on ART and Sixty-one apparently healthy individual control. Glucose-6-Phosphate Dehydrogenase (G-6-PD) activity, Pyruvate kinase (PK) activity, Activated Partial Thromboplastin time (APTT), Prothrombin time (PT), Platelet count (PLT), CD4 count, total white cell count (TWBC), differential WBC count (NEUT, LYM and MXD) and Human Immunodeficiency virus (HIV) status were determined. Results: In ART subjects, APTT and PT were significantly prolonged in subjects with CD4 count 0.05). In non-ART, G-6-PD activity was significantly lower in subjects with CD4 count 0.05). Conclusion: This study showed that in ART subjects, APTT, PT, TWBC and LYM were prolonged with progression of HIV infection, while in non-ART, G-6-PD and APTT were decreased with HIV progression as depicted by decreased CD4 count.
Design of Pulse Oximeters

Normal oxygen transport (S A Clark). Motivation of pulse oximetry (D J Sebald). Blood oxygen measurement (J Farmer). Light absorbance in pulse oximetry (O Wieben). Light-emitting diodes and their control (B W J Bourgeois). Photodetectors and amplifiers (J S Schowalter). Probes (M V S Reddy). Electronic instrument control (K S Paranjape). Signal processing algorithms (S Palreddy). Calibration (J S Schowalter). Accuracy and errors (S Tungjitkusolmun). User interface for a pulse oximeter (A Lozano-Nieto). Applications of pulse oximetry (J B Ruchala). Glossary. Index.
Indian women, health, and productivity

The relationship between women's health and their (physical and economic) productivity is complex and multi-dimensional. It is characterized by"flows"in both directions and a host of intervening factors. Two simple statements summarize the major directional flows: (a) women's health affects their productivity; and (b) productivity affects women's health. In the latter case, women's own productivity, that of their households, and even that of larger units such as the local, regional or national economy may be implicated. Women's health is intricately linked with family health, and their productivity with family productivity and related characteristics. This paper documents the nature of these relationships, using available data on Indian women which relate to a variety of health indices, and construing"productivity"in the broadest possible way, including labor force participation, work output, income and so on. The overall purpose is to discuss women's health with the context of the need to improve both women's productivity and welfare. Women's health status, its determinants and consequences, are explored, leading ultimately to the identification of interventions required to improve it and thereby to improve women's productivity.
Effect of Some Sources of Antioxiadnts on The Productive and Reproductive Performance of Turkey Hens

The objective of this study was to investigate the effect of using some sources of antioxidants on the productive and reproductive performance of turkeys. This study was carried out at Mehalet Mousa Animal Production Research Station, Kafr ElSheikh, belonging to the Animal Production Research Institute, Agricultural Research Center, Ministry of Agriculture, Egypt. A total of 84 Bronze female turkeys, 32 weeks of age were used. The birds were randomly distributed into 7 experimental groups; each consisted of three equal replicates. The birds were individually housed in battery cages. The experimental period lasted 12 weeks (from 32 to 44 weeks of age). The birds were fed a yellow corn-soybean meal-based diet, supplemented with two antioxidants, zinc and selenium of three sources organic, inorganic and nano forms. The experimental groups were fed one of the following diets: (1) a basal diet without added zinc or selenium; (2) inorganic zinc (zinc oxide) 100 mg/kg diet; (3) organic zinc (zincmethionine) 100 mg/kg diet; (4) nano zinc (zinc oxide nanoparticles) 40 mg/kg diet; (5) inorganic selenium (sodium selenite) 0.3 mg/kg diet; (6) organic selenium (selenomethionine) 0.3 mg/kg diet; (7) nano selenium (selenium nano-particles) 0.15 mg/kg diet. The results obtained can be summarized as follows. Dietary supplementation with inorganic, organic and nano forms of zinc and selenium significantly (P≤0.05) increased serum levels of total protein, concentrations of blood haemoglobin, egg fertility, hatchability of eggs in turkey hens, and significantly (P≤0.05) improved feed conversion ratio as compared to that of the controls. Dietary supplementation with inorganic, organic and nano forms of zinc and selenium significantly (P≤0.05) decreased feed consumption, serum levels of total lipids and cholesterol as compared to those of the controls. Supplementation of organic and nano forms of zinc and addition of inorganic, organic and nano forms of selenium to diets of laying turkey hens significantly (P≤0.05) increased hen-day egg production rate and egg weight as compared to those of the controls. Dietary organic and nano forms of zinc and selenium of turkey hens caused significant increases (P≤0.05) in serum antibody titres against Newcastle disease virus and improved immunity, and exhibited a significant increase in relative weight of spleen and oviduct length compared with their control group. Turkey hens fed diets supplemented with organic and nano Se produced eggs with better albumen quality and egg shell quality as measured by Haugh units and egg shell thickness as compared to that of the control turkey hens. There were no significant differences among the different dietary treatments in relative weights of egg components, egg shape index, egg yolk index, yolk color score, relative weights of carcass yield, liver and heart of turkey hens. It can be concluded that dietary supplementation with organic and nano forms of zinc and selenium can induce beneficial effects on productive and reproductive performance of turkey hens.
Toxicity Studies in Mice Treated with 1-β-d-Arabinofuranosyl-cytosine (ara-C)

Summary Optimum therapeutic dosage schedules of 1-β-d-arabinofuranosylcytosine (ara-C) administered intraperitoneally in mice (15 mg/kg/dose, every 3 hours for 24 hours) result in karyorrhectic damage to the crypt epithelial cells of the intestinal mucosa. This damage is most severe at 4 hours (earliest observations made) following conclusion of the 24-hour course, after which there is a rapid recovery to completion in 72 hours. The damage is thus transitory and resembles that of hydroxyurea. This cycle of transitory intestinal damage followed by recovery occurs after each therapeutic dosage schedule of ara-C as long as the schedule is not repeated more often than every 4th day. Progressive damage to the intestinal mucosa accompanied by changes in the hematopoietic tissues occurs only if this optimum therapeutic dose (15 mg/kg/dose, every 3 hours) is continued uninterrupted to the LD 100 dose (360 mg/kg in 72 hours) and beyond. Irreversible changes are seen in the intestinal mucosa, and a progressive depopulation of the bone marrow with ultimate aplasia ensues as the LD 100 dose is reached and surpassed.
A study to explore the perceptions that South African chiropractors have regarding the perceived role and impact of research within the profession

The Chiropractic profession has made significant progress with regard to the production of high quality and clinically relevant research in the last 20 years. This correlates with a spike in development within the chiropractic profession as well as its acceptance by the medical fraternity and public. The responsibility for continuing this positive trend is dependent on the chiropractic graduates and practitioners of the future. Therefore, it is important to establish the current perceptions and utilization of research by Chiropractors, so that future research can be built around the needs and requirements of today’s practitioners, thereby ensuring the profession’s continued development and future in health care. The aim of this study was to determine the perceptions that Chiropractors have of research and its relevance / utilization in practice. Method: The study was a quantitative questionnaire based, self administered survey. The sample group included all Chiropractic practitioners currently practising in South Africa (N=515). Results: There was a response rate of 35% (n=174). The results indicated that the perception of research was very positive overall, with the strongest positive response being that research adds credibility to the profession. However, most respondents disagreed with the statement that chiropractors who had done research had an advantage above those who had not. There was a positive, albeit weak correlation between perceptions and utilization of research, indicating that as perceptions increased, so did utilization of research. The area of greatest concern was that even though a high degree of research utilization was reported by chiropractors, research was least likely to be used to change conditions, policies or practices in practice. v Conclusion: The most significant factors associated with positive perceptions and utilization were found to be publishing in a journal and receiving referrals from other health care practitioners. Chiropractors who indicated an interest in doing research again were also very positively linked to utilization. It would seem that even though chiropractors perceive research positively, their implementation into practice has some hurdles that impede the full integration of research into practice. As very few demographic and personal attributes of the South African chiropractor were found to be primarily responsible for low utilization of research in practice, it can be hypothesised that the factors impeding research implementation are most likely environmental in nature.
‘Sport as a Resource Caravan’: Understanding How Adults Utilize Sport as a Developmental Tool

Abstract Sport-for-development research consistently focuses on studies of macro level policy, meso level community development, and micro level individual development. However, individual development has largely focused on positive youth development through sport. Further, development outcomes have been studied with reference to a single program. This study examines the aggregate value of sport in development across the lifespan. Specifically, it examines the role of sport to facilitate or hinder adaptation to life transitions. A life-history, thematic analysis with data from semi-structured interviews and life maps with 15 participants aged 50 and older was conducted. Results revealed sport’s role as an effective resource provider via social exchanges when participants faced a disruption caused by a life event transition. This is significant as sport may help provide access to scarce resources theorized to alter the fundamental developmental process of an individual’s life-course (i.e. transitions). With this research, innovative sport designs and intentional sport management strategies that influence developmental trajectories in adults could emerge. Practical suggestions for program design and marketing are recommended.
Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

The oil of the fruits of Euterpe oleracea Mart. , Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.
Sexual Pain Disorders: Dyspareunia and Vaginismus

Pain is almost never “psychogenic,” except for pain from grieving. Pain has biological basis, when it is the alerting signal of an impending or current tissue damage from which the body should withdraw it is defined as “nociceptive” [1]. When pain becomes a disease per se, i.e. it is generated within the nerves and nervous centers, it is called “neuropathic” [1-3]. It is a complex perceptive experience, involving psychological and relational meanings, which may become increasingly important with the chronicity of pain [1-3].
Intra-Arterial Therapy for Cardioembolic Internal Carotid Artery Terminus Occlusion: The Past and Present Status in Real Practice

Acute ischemic stroke with the occlusion of internal carotid artery terminus (ICAT) is associated with a high rate of mortality and poor functional outcome in survivors (1, 2). Early, complete revascularization of the occluded internal carotid artery (ICA) is essential to improve outcome in this condition (3). However, pharmacological treatment using intravenous (IV) or intra-arterial (IA) thrombolysis is associated with lower recanalization rates in ICAT occlusion, mainly because of large clot burden (1, 4-6). Additional to the IA thrombolysis, several methods of mechanical clot disruption using microcatheter, microguidewire, balloon or stent are attempted to improve recanalization rates for large vessel occlusions. These methods facilitate pharmacologic thrombolysis by fragmenting the clot and increasing the surface area exposed to lytic agents. Some previous studies showed higher recanalization rates of these multimodal approaches than IA thrombolysis alone, but the clinical benefit is unclear (7-10). Recent advances in IA techniques and thrombectomy devices Intra-Arterial Therapy for Cardioembolic Internal Carotid Artery Terminus Occlusion: The Past and Present Status in Real Practice 심장성색전으로 인한 내경동맥 말단폐색의 동맥내 치료: 실제 임상에서의 과거와 현재
Education as a practice of freedom

Objective : To review on the book " Education As a practice of freedom " Method : A critical analysis . Results: the book shows the view of the method of teaching adult literacy . Why not just be a spectator , the ideas it presented demonstrate trademarks of experience in Brazil in the 1960s . Conclusion : As a classic reading of this work and of paramount importance to the conceptual understanding of continuing health education , because it encourages us to reflect on our educational processes in vocational training and health education through learning seeking significant change for people people who change the world .
Quality of Life of The Partners of African American Women with Breast Cancer

QUALITY OF LIFE OF THE PARTNERS OF AFRICAN AMERICAN WOMEN WITH BREAST CANCER Patricia C. Smith, Ph.D. George Mason University, 2013 Dissertation Director: Dr. Charlene Douglas The high morbidity, mortality, and treatment of breast cancer in African American women may negatively impact the quality of life of the patients and their partners. This descriptive quantitative study explored the self-reported quality of life of the partners of African American women with breast cancer in a large city and suburbs of the United States’ Mid-Atlantic Region. The study surveyed African American couples whose female spouse had a diagnosis of breast cancer, who were over the age of 18, and who were married or cohabiting with a male. A demographics questionnaire for the women, a demographics questionnaire for their male partners, and the Caregiver Quality of Life Index-Cancer (CQOLC) scale were used to collect the data. Descriptive statistics were computed using SPSS for couples’ demographic variables. Bivariate SpearmanRank Correlations and Kruskal-Wallis One-Way ANOVA were used to assess the relationship between sociodemographic variables and quality of life. Bivariate SpearmanRank correlations found statistically significantly, positive correlations between the age of the male partner and the Burden total score. Kruskal-Wallis One-Way ANOVAs comparing differences in average Burden, Disruptiveness, Positive Adaptation, and Financial Concerns partners’ total scores with marital status, religion, employment status, highest level of educational attainment and African American women’s stage at breast cancer diagnosis findings showed that the average male partner’s CQOLC Burden total score differed significantly by employment status. Data from descriptive statistics and independent t-tests demonstrated not currently employed male partners having a lower mean total Burden score. The average total male partners’ caregiver quality of life score was 74.8 with a standard deviation of ±15.55; the minimum possible score was 0 and the maximum possible score was 140. The findings support the need for nurses and all healthcare providers to provide ongoing communication with patients and their partners and to develop culturally sensitive, age specific education and support.
Hubungan Frekuensi Konsumsi Fast Food Dan Status GiziDengan Usia Menarche Dini Pada SiswiSekolah Dasar Di Surakarta

Latar Belakang :Menarche merupakan menstruasi yang pertama kali terjadi pada perempuan. Hasil Riskesdas 2010 diketahui bahwa 20,9% anak perempuan di Indonesia mengalami menarche di umur kurang dari 12 tahun. Faktor yang dapat mempengaruhi menarche dini antara lain konsumsi makanan dan status gizi. Tujuan : Mengetahui hubungan frekuensi konsumsi fast food dan status gizi dengan usia menarche dini pada siswi sekolah dasar di Surakarta. Metode : Jenis penelitian ini adalah observasional dengan metode cross sectional. Teknik pengambilan sampel menggunakan proportional random sampling. Subjek penelitian ini adalah siswi yang sudah menstruasi dengan jumlah sampel 53 subjek. Frekuensi konsumsi fast food dihitung menggunakan FFQ. Status gizi dihitung menggunakan IMT/U dan usia menarche menggunakan kuesioner. Pengumpulan data penelitian ini menggunakan kuesioner. Teknik analisis yang digunakan adalah Chi-Square. Hasil :Hasil uji Chi-Square hubungan frekuensi konsumsi fast food dengan usia menarche dini sebesar p=0,736, sehingga tidak terdapat hubungan frekuensi konsumsi fast food dengan usia menarche dini. Selanjutnya hasil uji Chi Square hubungan status gizi dengan usia menarche dini sebesar p=0,021, sehingga terdapat hubungan yang signifikan antara status gizi dengan usia menarche dini. Kesimpulan : Tidak ada hubungan antara frekuensi konsumsi fast food dengan usia menarche dini. Terdapat hubungan antara status gizi dengan usia menarche dini.
Orocecal Transit Time in Normal Adults at Cipto Mangunkusumo National General Hospital, Jakarta

Helicobacter pylori has been known as a cause of chronic gastritis, a predisposition to gastric and duocenal ulcers, and a class I gastric carcinogen. Throughout the world, H. pylori infection is very common, reaching 40% -50% of the population in developed nations and 80% – 90% of the population in developing nations. Several techniques have been used to detect H. pylori infection, such as the urea breath test, rapid urease test, serological test, as well as biopsies of gastric or duodenal tissues for culture and histopathology. In this review article, we will discuss a relatively new method to detect H. pylori antigen in stools with enzyme immunoassay, and comparisons with other standard techniques. However, the H. pylori stool antigen test is not yet commercially available in Indonesia. Key words: Helicobacter pylori - stool antigen - enzyme immunoassay
The first year experience: perceptions of students at a new campus

This study was conducted in a bid to better understand the student cohort at the new campus of the University of Southern Queensland. The project was designed to follow on from the findings of a recent nation-wide review of first year students conducted by the Centre for the Study of Higher Education at the University of Melbourne (Krause, Hartley, James, & McInnis, 2005). Studies focusing on the experiences and perceptions of vulnerable student cohorts provide valuable information to academic and support staff at universities and enable institutions to better meet student needs. The cohort in this context differed in several respects from those of previous studies, specifically in terms of the much greater proportion of students who were of a low to middle socio-economic status, as well as a larger proportion of mature-age students. The findings are relevant in terms of providing meaningful student experiences, assisting students to connect theoretical frameworks with their home experiences, engaging students, developing innovative teaching and learning practices within this context and improving students’ perceptions of quality assurance. The demographics of the current sample indicate a cohort of students in previously marginalised groups and as such the current research constitutes a unique contribution to the investigation of first year experiences.
Clinical Handbook of Weight Management

Preface 1. Introduction 2. The Scale of the Problem 3. The Causes of Weight Gain and Patterns of Weight Change in Different Communities and Individuals 4. The Burden of Ill-health from Obesity 5. Clinical Benefits of Weight Loss 6. Clinical Guidelines for Weight Management 7. Dietary, Behavioural and Exercise Strategies 8. The Role of Drug Therapy 9. Surgery for Obesity 10. Establishing and Running a Weight Management Service 11. Medical and Health Service Costs of Obesity and its Management 12. Epidemic Control: the Quest for Primary Prevention 13. Appendices 14. References 15. Index