Miracle-dz/UniFAR-FTUs huggingface dataset:
Primary Interoceptive Cortex Activity during Simulated Experiences of the Body

Studies of the classic exteroceptive sensory systems (e.g., vision, touch) consistently demonstrate that vividly imagining a sensory experience of the world—simulating it—is associated with increased activity in the corresponding primary sensory cortex. We hypothesized, analogously, that simulating internal bodily sensations would be associated with increased neural activity in primary interoceptive cortex. An immersive, language-based mental imagery paradigm was used to test this hypothesis (e.g., imagine your heart pounding during a roller coaster ride, your face drenched in sweat during a workout). During two neuroimaging experiments, participants listened to vividly described situations and imagined “being there” in each scenario. In Study 1, we observed significantly heightened activity in primary interoceptive cortex (of dorsal posterior insula) during imagined experiences involving vivid internal sensations. This effect was specific to interoceptive simulation: It was not observed during a separate affect focus condition in Study 1 nor during an independent Study 2 that did not involve detailed simulation of internal sensations (instead involving simulation of other sensory experiences). These findings underscore the large-scale predictive architecture of the brain and reveal that words can be powerful drivers of bodily experiences.
Association of hypocalcemia with congenital heart disease in 22q11.2 deletion syndrome

Hypocalcemia is one of the cardinal features of the chromosome 22q11.2 deletion syndrome (22q11.2DS), the most common cause of DiGeorge syndrome. Hypocalcemia and other features of 22q11.2DS including congenital heart disease (CHD) are primarily ascribed to problems with morphogenesis and function of the pharyngeal arch system derivatives including the parathyroid glands, the aortic arch, and the cardiac outflow tract. In light of the aforementioned embryology, we hypothesized that hypocalcemia would be identified more frequently in those patients with 22q11.2DS and CHD. We conducted a retrospective IRB approved chart review on 1,300 subjects with 22q11.2DS evaluated at the Children's Hospital of Philadelphia. χ2 test was used to evaluate the statistical significance of differences in hypocalcemia between the two groups. Eight hundred fifty‐two patients had calcium levels available for review. Of these, 466 (54.69%) had a history of hypocalcemia and 550 (64.55%) had CHD. Of those with CHD, 343 (62.36%) had a history of hypocalcemia, and of those without CHD, only 123 (40.73%) had a history of hypocalcemia. Thus, the frequency of diagnosed hypocalcemia was greater in patients with 22q11.2DS and CHD as compared to those without CHD (p < .001). We also analyzed age of onset of hypocalcemia and found that 66.47% of CHD/hypocalcemia group had neonatal/infantile hypocalcemia versus 43.09% in the non‐CHD/hypocalcemia group. In our large cohort of patients with 22q11.2DS, the prevalence of diagnosed hypocalcemia is elevated among patients with CHD, in whom it is more likely to be diagnosed during the neonatal/infancy period.
Observations of Turbulence in Free Atmosphere by Balloon-Borne Sensors

In recent years, Thorpe analysis has been used to retrieve the characteristics of turbulence in free atmosphere from balloon-borne sensor data. However, previous studies have mainly focused on the mid-high latitude region, and this method is still rarely applied at heights above 30 km, especially above 35 km. Therefore, seven sets of upper air (>35 km) sounding data from the Changsha Sounding Station (28°12′ N, 113°05′ E), China are analyzed with Thorpe analysis in this article. It is noted that, in the troposphere, Thorpe analysis can better retrieve the turbulence distribution and the corresponding turbulence parameters. Also, because of the thicker troposphere at low latitudes, the values of the Thorpe scale LT and turbulent energy dissipation rate ε remain greater in a larger height range. In the stratosphere below the height of 35 km, the obtained ε is higher, and Thorpe analysis can only be used to analyze the characteristics of large-scale turbulence. In the stratosphere at a height of 35–40 km, because of the interference of sensor noise, Thorpe analysis can only help to retrieve the rough distribution position of large-scale turbulence, while it can hardly help with the calculation of the turbulence parameters.
Comparison of variations in cornea after one-handed and two-handed coaxial phacoemulsification

Purpose To compare corneal variations in patients undergoing one-handed and two-handed coaxial phacoemulsification. Setting Eye Institute, Affiliated Hospital of Nantong University, Nantong, China. Design Prospective consecutive nonrandomized comparative cohort study. Methods Patients with cataracts were subject to one-handed (one-handed group) or two-handed coaxial phacoemulsification (two-handed group). Intraoperative phaco parameters and postoperative outcomes, such as visual acuity, surgically induced astigmatism (SIA), corneal volume, central corneal thickness, and corneal endothelial cell counts/size were compared. Results No significant differences in the intraoperative phaco parameters were noted between the 2 groups. At postoperative week 1, visual outcomes were significantly improved in the one-handed compared with the two-handed group (all P<0.05). Corneal volume, central corneal thickness, and average cell size were significantly decreased in the one-handed group compared with two-handed group (all P<0.05), but the aforementioned differences were ameliorated at 1 month and 3 months postoperatively. Endothelial cell loss was significantly decreased in the one-handed group compared with the two-handed group at any follow-up point (all P<0.05). No significant differences in SIA on the anterior surface were noted between the 2 groups. SIA on the posterior surface was significantly decreased in the one-handed group compared with the two-handed group at 1 week postoperatively (P=0.043) but not at 1 month and 3 months postoperatively. Conclusion One-handed phacoemulsification has the advantages of less trauma to the cornea and better early visual outcomes compared with the two-handed technique.
Comparison of short-term outcomes between minimally invasive McKeown and Ivor Lewis esophagectomy for esophageal or junctional cancer: a systematic review and meta-analysis

Purpose Minimally invasive esophagectomy is increasingly performed for esophageal or gastroesophageal junctional cancer, with advantages of improved perioperative outcomes in comparison with open esophagectomy. McKeown and Ivor Lewis are widely used procedures of minimally invasive esophagectomy, and there have been controversies on which one is preferred for patients with resectable esophageal or junctional cancer. Patients and methods This review was registered at the International Prospective Register of Systematic Reviews (number CRD42017075989). Studies in PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov were thoroughly investigated. Eligible studies included prospective and retrospective studies evaluating short-term outcomes of minimally invasive McKeown esophagectomy (MIME) vs minimally invasive Ivor Lewis esophagectomy (MILE) in patients with resectable esophageal or junctional tumors. Main parameters included anastomotic leak and 30-day/in-hospital mortality. Overall incidence rates (ORs)/weighted mean difference (WMD) with 95% confidence intervals (CIs) were calculated by employing random-effects models. Results Fourteen studies containing 3,468 cases were included in this meta-analysis. Age, male sex, and American Joint Committee on Cancer (AJCC) stage between the 2 groups were not statistically different. MIME led to more blood loss, longer operating time, and longer hospital stay than MILE. MIME was associated with higher incidence of pulmonary complications (OR =1.96, 95% CI =1.28–3.00) as well as total anastomotic leak (OR =2.55, 95% CI =1.40–4.63), stricture (OR =2.07, 95% CI =1.05–4.07), and vocal cord injury/palsy (OR =5.62, 95% CI =3.46–9.14). In addition, the differences of R0 resection rate, number of lymph modes retrieved, blood transfusion rate, length of intensive care unit stay, incidence of cardiac arrhythmia, and Chyle leak between MIME and MILE were not statistically significant. Notably, incidence of severe anastomotic leak (OR =1.28, 95% CI =0.73–2.24) and 30-day/in-hospital mortality (OR =1.76, 95% CI =0.92–3.36) as well as 90-day mortality (OR =2.22, 95% CI =0.71–6.98) between the 2 procedures were also not significantly different. Conclusion This study suggests that MIME and MILE are comparable with respect to clinical safety. MILE may be a better option when oncologically and clinically suitable. MIME is still a safe alternative procedure when clinically indicated. However, this evidence is at risk for bias; randomized controlled trials are needed to validate or correct our results.
Global Model of Plasmaspheric Hiss from Multiple Satellite Observations

Gyroresonant wave particle interactions with plasmaspheric hiss play a fundamental role in the dynamics of the Earth's radiation belts and inner magnetosphere, affecting the loss of radiation belt electrons. Knowledge of the variability of the wave power of plasmaspheric hiss as a function of both spatial location and geomagnetic activity, required for the computation of pitch angle and energy diffusion rates, is thus a critical input for global radiation belt models. To build a comprehensive model of plasmaspheric hiss in the inner magnetosphere we combine plasma wave data from eight satellites, equipped to measure wave magnetic field intensities. Specifically, we use approximately 3 years of data from Dynamics Explorer 1, 1 year of data from Double Star TC1, 10 years of data from Cluster 1, 17 months of data from each of THEMIS-A, THEMIS-D and THEMIS-E, and 3 years of data from the Van Allen probes, RBSP-A and RBSP-B. The new model extends the coverage and improves the statistics of existing models based on data from individual satellite missions, particularly at mid to high latitudes. We develop geomagnetic activity dependent templates to separate plasmaspheric hiss from chorus emissions enabling us to isolate the plasmaspheric hiss emissions. In this presentation the global morphology of the average plasmaspheric hiss wave power will be examined as a function of frequency and geomagnetic activity. Implications for the source of plasmaspheric hiss and radiation belt modelling will be discussed. The results will also compared with previous models of plasmaspheric hiss based on wave electric field measurements.
Investigating the Electronic Properties of Oxygen Vacancies in Anatase TiO2: An Ab Initio Study

Metal oxide dielectrics are known as promising candidates for resistive switching or memristor applications. TiO2has been shown to be one of the favorites for the implementation of resistive switching devices. The mobile oxygen vacancies in TiO2 are recognized as the main source of resistive switching behavior. Therefore, the investigation of atomic scale properties of oxygen vacancies is of crucial importance for the description of microscopic phenomena leading to the resistive switching behavior. In the present work we employed standard DFT within the GGA approximation as well as $\mathbf{GGA+U}$ correction to investigate the electronic properties of oxygen vacancies in anatase phase of TiO2. We show that the Hubbard-like term (U) is essential for the correct description of the electronic properties. The defect formation energies at different charged states and the charge transition levels are calculated for different values of U-term. It has been shown that a value of $\mathbf{U}=3.5\ \mathbf{eV}$ is the best choice to obtain reasonable results for the band gap as well as the position of induced defect levels, at same time. Moreover, we show that the $\mathbf{q}=\pmb{+2}$ charged state is the energetically most favorable state for the oxygen vacancy in TiO2.
Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations

Purpose The characteristic expression of DNA damage response proteins in familial breast cancers with BRCA1, BRCA2, or non-BRCA1/2 mutations has not been analyzed in Chinese patients. Our study aimed to assess the differential expression of microcephalin 1 (BRIT1), ATM serine/threonine kinase (ATM), checkpoint kinase 2 (CHEK2), BRCA1, RAD51 recombinase (RAD51), and poly (ADP-ribose) polymerase 1 (PARP-1) and establish the profile of Chinese familial breast cancers with different mutation status. Methods We constructed five tissue microarrays from 183 familial breast cancer patients (31 with BRCA1 mutations; 14 with BRCA2 mutations, and 138 with non-BRCA1/2 mutations). The DNA response and repair markers used for immunohistochemistry analysis included BRIT1, ATM, CHEK2, BRCA1, RAD51, and PARP-1. The expressions of these proteins were analyzed in BRCA1/2 mutated tumors. The association between pathologic characteristics with BRCA1/2 mutation status was also analyzed. Results In familial breast cancer patients, BRCA1 mutated tumors were more frequent with high nuclear grade, estrogen receptor/progesterone receptor/human epidermal growth factor receptor 2 negative, low Ki-67, and positive CK5/6. BRCA1 mutated tumors had lower CHEK2 and higher cytoplasmic BRIT1 expression than BRCA2 and non-BRCA1/2 mutation tumors. BRCA2-associated tumors showed higher CHEK2 and cytoplasmic RAD51 expression than those in other groups. Nuclear PARP-1 expression in BRCA1/2-associated tumors was significantly higher than in non-BRCA1/2 mutation tumors. Moreover, we found quite a few of negative PARP-1 expression cases in BRCA1/2 mutated groups. Conclusion The clinicopathologic findings of BRCA1-associated Chinese familial breast cancers were similar to the results of other studies. Chinese familial breast cancer patients with BRCA1/2 mutations might have distinctive expression of different DNA damage response proteins. The reduced expression of PARP-1 in Chinese BRCA1/2 mutated breast cancer patients could influence the therapeutic outcome of PARP-1 inhibitors.
Adverse events, resource use, and economic burden associated with mantle cell lymphoma: a real-world assessment of privately insured patients in the United States

Abstract In view of recent therapeutic advances in mantle cell lymphoma (MCL), the aim of this retrospective cohort analysis was to assess treatment patterns, adverse events (AEs), resource utilization, and health care costs in patients with MCL in a US-based commercial claims database. A total of 783 patients with MCL (median age = 65 years) were selected. Among patients receiving systemic therapy (n = 457), the most common treatment regimens were bendamustine/rituximab (BR) (41.1%), rituximab/cyclophosphamide/doxorubicin/vincristine (RCHOP) (26.7%), rituximab monotherapy (20.4%), and ibrutinib monotherapy (14.2%). Mean monthly costs during treatments with BR, RCHOP, rituximab, and ibrutinib were $12,958, $24,719, $13,153, and $21,690, respectively. Mean monthly cost during follow-up was $13,650 among patients with ≥6 AEs versus $5131 among those without AEs. The costs of MCL varied considerably by treatment regimen and care setting. The overall economic burden of managing patients with MCL can be substantially affected by costs associated with managing AEs occurring during treatment.
BEDEN EĞİTİMİ VE SPOR YÜKSEKOKULU ÖĞRENCİLERİNİN KARİYER GELECEĞİ ALGI DÜZEYLERİNİN İNCELENMESİ

Bu arastirmanin amaci, universite ogrencilerinin kariyer gelecegi algi duzeylerinin farkli degiskenlere gore farklilasip farklilasmadigini ortaya koymaktir. Arastirmanin modeli, nicel arastirma yontemlerinden betimsel niteliktedir. Arastirma grubunu Karamanoglu Mehmetbey Universitesinde ogrenim goren 508 ogrenci olusturmaktadir. Arastirmaya katilanlarin kariyer gelecegi algisini belirlenmesi amaciyla, Rottinghaus, Day ve Borgen (2005) tarafindan gelistirilen Kariyer Gelecegi Olcegi (KARGEL) kullanilmistir. Olcumlerin, normal dagilima uygun olup olamadigini belirlemek icin tek orneklem Kolmogorov Smirnov Testi uygulanmistir. Kariyer uyumlulugu alt boyutu normal dagilim gosterdigi icin t ve Anova testleri uygulanarak anlamlilik P>. 05 alinmis, fakat diger boyutlarda normal dagilim gostermedigi icin verilerin cozum ve yorumlanmasinda, Kruskal Wallis-H testi ve Mann Whitney-U testi kullanilarak anlamlilik duzeyi P<. 05 alinmistir. Verilerin degerlendirilmesinde ve hesaplanmis degerlerin bulunmasinda SPSS (Statistical package for social sciences) paket programi kullanilmistir. Arastirmaya katilan ogrencilerin genel kariyer gelecegi boyutu ortalamalasi (Ort.=83,58) ve kariyer gelecegi alt boyutlarindan kariyer iyimserligi puan ortalamasi (Ort.=36,65) orta seviyede, kariyer uyumlulugu alt boyut puan ortalamasi (Ort.=37,61) yuksek seviyede ve is piyasasina iliskin algi bilgisi alt boyut puan ortalamasi ise (Ort.=9,31) orta duzeyin uzerinde oldugu soylenebilir. Kisisel ozelliklere gore ise universite ogrencilerinin kariyer gelecegi algi duzeylerinin baba ogrenim durumu, “Bos zamanlarini nasil degerlendirir siniz? ” ve “Bos Zamanlarini Degerlendirmede Gucluk Cekiyor musunuz? ” degiskenlerine gore anlamli bir farklilik bulunurken, diger degiskenlerine (Yas, Cinsiyet, Gelir durumu Anne egitim, Aktif spor yapma durumu ve Bos zaman yeterlimi? ) gore anlamli bir fark bulunamamistir.
Distinctive Performance Analysis of CCB and PO Based MPPT Technique for Grid Connected PV Generation System

Photovoltaic based generating system has been proved to be comparably a better solution than the other counterparts in the category of renewable based generation. But, highly dynamic, fitful and non-linear characteristics of PV system due to compassion towards climatic parameters such as irradiation and temperature change has led to incorporation of maximum power point tracking techniques for extraction of maximum power and enhancement of overall efficiency of the generation system. In this paper a popular current control based (CCB) MPPT technique is presented and is contrasted with conventional Perturb and Observe (PO) MPPT technique. The simulation results are compared based on power, current and voltage generated from three phase grid connected PV system based on dc-dc boost converter. The responses of the proposed method clearly demonstrates the enhancement of both steady state and transient responses as well as provides the MPP value nearest to the corresponding maximum power of PV. The validation and justification of the improvements achieved by the proposed controller are realized using MATLAB/Simulink environment.
An Effective and Scalable Framework for Authorship Attribution Query Processing

Authorship attribution aims at identifying the original author of an anonymous text from a given set of candidate authors and has a wide range of applications. The main challenge in authorship attribution problem is that the real-world applications tend to have hundreds of authors, while each author may have a small number of text samples, e.g., 5–10 texts/author. As a result, building a predictive model that can accurately identify the author of an anonymous text is a challenging task. In fact, existing authorship attribution solutions based on long text focus on application scenarios, where the number of candidate authors is limited to 50. These solutions generally report a significant performance reduction as the number of authors increases. To overcome this challenge, we propose a novel data representation model that captures stylistic variations within each document, which transforms the problem of authorship attribution into a similarity search problem. Based on this data representation model, we also propose a similarity query processing technique that can effectively handle outliers. We assess the accuracy of our proposed method against the state-of-the-art authorship attribution methods using real-world data sets extracted from Project Gutenberg. Our data set contains 3000 novels from 500 authors. Experimental results from this paper show that our method significantly outperforms all competitors. Specifically, as for the closed-set and open-set authorship attribution problems, our method have achieved higher than 95% accuracy.
Stabilization of Switched Linear Neutral Systems: An Event-Triggered Sampling Control Scheme

Event-triggered control is an effective control strategy, capable of reducing the amount of communications and retaining a satisfactory closed-loop performance. In this paper, we aim at proposing an event-triggered sampling mechanism and studying observer-based output feedback control for switched linear neutral systems with mixed time-varying delays. Different from the conventional event-triggered control strategies, our proposed one transmits not only the state but also the switching information to the controller, which is advantageous in applications where the measured outputs and the switching information have to be transmitted over a communication network. Moreover, asynchronous switchings may be caused between the subsystems and their matched subcontrollers under the proposed sampling mechanism, which increases difficulties in analyzing stability. We develop a sufficient condition, under which the proposed control scheme guarantees globally the exponential stability of the closed-loop system meanwhile taking into account asynchronous switchings. Finally, an illustrative example is given to show the effectiveness of the proposed method.
Relation Between Infant Microbiota and Autism?: Results from a National Cohort Sibling Design Study

Background: Hypotheses concerning adverse effects of changes in microbiota have received much recent attention, but unobserved confounding makes them difficult to test. We investigated whether surrogate markers for potential adverse microbiota change in infancy affected autism risk, addressing unobserved confounding using a sibling study design. Methods: This is a population-based, prospective cohort study including all singleton live births in Denmark from 1997 to 2010. The exposure variables were cesarean delivery and antibiotic use in the first 2 years of life. The outcome was a subsequent autism diagnosis. We used the between- and within-sibling model and compared it with sibling-stratified Cox models and simpler standard Cox models that ignored sibship. Results: Of our study population including 671,606 children, who were followed for up to 15 years (7,341,133 person-years), 72% received antibiotics, 17.5% were delivered by cesarean, and 1.2% (8,267) developed autism. The standard Cox models predicted that both cesarean (compared with vaginal) delivery and antibiotics increased the risk of autism. In the sibling-stratified Cox model, only broader spectrum antibiotics were associated with increased risk of autism: hazard ratio (HR) = 1.16 (95% confidence interval = 1.01, 1.36). The between–within model estimated no exposure effects: intrapartum cesarean HR = 1.06 (0.89, 1.26); prelabor cesarean HR = 0.97 (0.83, 1.15); exclusively penicillin HR = 1.05 (0.93, 1.18); and broader spectrum antibiotics HR = 1.05 (0.95, 1.16). Conclusions: The between–within model rendered more precise estimates than sibling-stratified Cox models, and we believe that it also provided more valid estimates. Results from these preferred models do not support a causal relation between antibiotic treatment during infancy, cesarean delivery, and autism. See video abstract at, http://links.lww. com/EDE/B432.