Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationships between managing talent practices, knowledge management and organizational performance of Malaysian private colleges

The purpose of this study was to investigate the organizational performance of private colleges in association with managing talent practices, and to evaluate the mediation role of knowledge management on the relationship between practices of managing talent attraction and recruitment, talent development and talent retention with the organizational performance of private colleges. PLS-SEM technique was deployed to test the hypothesized relationships in the model. A questionnaire was developed with 41 items adapted from previous validated scales. The survey method was used to collect quantitative data for all the variables in the study. The non-probability sampling approach of convenience sampling was utilized. 1300 questionnaires were administered to 260 private colleges in Malaysia. The unit of analysis was at the individual level. Five respondents per college were surveyed and this provided a sample size of 243 representing 49 private colleges. A response rate of 18.7% was achieved. Empirical findings in this study highlighted that managing talent development has a significant positive relationship with the organizational performance of private colleges. Knowledge management has a significant direct positive relationship with the organizational performance of private colleges. The practices of managing talent attraction and recruitment, talent development and talent retention show significant positive influence on knowledge management among private colleges. The mediation effects of knowledge management are statistically significant, and partially mediates the relationship between practices of managing talent attraction and recruitment, talent development and talent retention with respect to the organizational performance of private colleges. The model shows a moderately strong explanatory power, besides making some theoretical and practical contributions.
Insight into the host–parasite interplay by proteomic study of host proteins copurified with the human parasite, Schistosoma japonicum

The tegument proteins of schistosome have attracted the most attention in studies of host–parasite interplay, while the host proteins acting at the host–parasite interface remained largely elusive. Here, we undertook a high‐throughput proteomic approach to characterize the schistosome‐adsorbed host proteins. Fifty five distinct host proteins were confidently identified in S. japonicum samples, including cercaria, schistosomula, adults, eggs, and miracidia, together with tegument and eggshell preparations, of which 23 and 38 host proteins were identified in adult worms and eggs, respectively. Among the schistosome‐adsorbed host proteins, host neutrophil elastases were found in the granuloma initiated by schistosome egg deposition, implying that the host innate immune molecules could participate in the granuloma formation for fighting against schistosome invasion, except for the adaptive immune system. In addition, some host proteins, such as proteinase inhibitor and superoxide dismutase, might be utilized by schistosome to counteract or attenuate the host attacks. These parasite‐adsorbed host proteins will provide new insights into the host immune responses against schistosome infection, the evasive behavior of the adult worms, and the granuloma formation, which could render an in‐depth understanding for the host–parasite interplay.
Peripheral arterial disease: the evolving role of non-invasive imaging

Peripheral arterial disease is usually secondary to stenotic or occlusive atherosclerosis and is both common and increasing in western society. The majority of symptomatic patients have intermittent claudication and only a minority (<2% and typically those with diabetes mellitus or renal failure) progress to critical limb ischaemia, heralded by the onset of rest pain and/or tissue loss. Imaging is largely reserved for patients with disabling symptoms in whom revascularisation is planned. In these patients, accurate depiction of the vascular anatomy is critical for clinical decision making as the distribution and severity of disease are key factors determining whether revascularisation should be by endovascular techniques or open surgery. Driven by advances in technology, non-invasive vascular imaging has recently undergone significant refinement and has replaced conventional digital subtraction angiography for many clinical indications. In this review, the relative merits and limitations of duplex ultrasound, CT angiography, and magnetic resonance angiography are discussed, emerging imaging techniques are described, and complications relating to the use of intravascular contrast agents are highlighted.
Clinical parameters as predictors of destructive periodontal disease activity.

Abstract The purpose of the present investigation was to evaluate the usefulness of clinical measurements of periodontal disease in predicting destructive periodontal disease activity. Periodontal status was monitored at 3414 sites in a total of 22 subjects. Repeat attachment level measurements recorded at 2-month intervals were analyzed by the tolerance method to detect destructive periodontal disease activity. The number of sites that showed or did not show activity and the absence or presence of a clinical parameter before and after the monitoring period were computed. The diagnostic sensitivity of a clinical parameter in predicting disease was expressed as the proportion of sites showing attachment loss which exhibited that parameter. Diagnostic specificity was expressed as the proportion of sites not exhibiting the clinical parameter and not showing attachment loss. In addition, the probability of false positive and false negative diagnoses were computed, using the assumption that the destructive periodontal disease activity rate of sites at risk was 3%. The sensitivity of clinical measurements of gingival redness, plaque, suppuration and bleeding on probing ranged from 0.03 (suppuration) to 0.42 (plaque). Specificity of these measurements was better, ranging from 0.71 for plaque to 0,97 for-suppuration. Disease activity was most often. associated with shallow pockets, but shallow pockets by far dominated she-sites at risk-. Thus; pocket-depth: of <4mm was a sensitive diagnostic test for disease activity (0.69), but the measured specificity of 0.25 indicated that it would be a poor predictor of disease activity. Molar teeth and interproximal surfaces were more likely sites of disease activity than other teeth or surfaces with sensitivity values of 0.52 and 0.83, and specificity values of 0.2S and 0.34, respectively. The probability of detecting false positives was high using any of the clinical parameters ranging from 0.95–0.97. Because no clinical parameter demonstrated high sensitivity and high specificity values, none of the clinical parameters used individually or in combination were found useful in predicting disease activity at individual sites.
Redundant Local-Loop Insertion for Unidirectional Routing

As the semiconductor manufacturing technology continues to scale down to sub-10 nm, unidirectional layout style has become the mainstream for lower metal layers with tight pitches. Conventional redundant via (RV) insertion for yield improvement has become obsolete because unidirectional routing patterns forbid off-track routing, i.e., wire bending, for the metal coverage of RVs. To enhance the yield, redundant local-loop insertion (RLLI) is a new way of inserting RVs due to its compatibility with the unidirectional layout style. This paper proposes the first global optimization engine for RLLI considering advanced manufacturing constraints. Our key contributions include bounded timing impact analysis and evaluation for the local-loop structure, net-based local-loop candidate generation and pruning, an integer linear programming (ILP) formulation and scalable iterative relaxation/linear programming solving (IRLS) with incremental search scheme. Experimental results demonstrate that with bounded timing impact (within 1%), the ILP formulation obtains highest insertion rate while the IRLS with incremental search scheme achieves scalable solutions with competitive solution qualities.
Pharmacokinetics and tissue penetration of orally administered lomefloxacin

The pharmacokinetics of the quinolone lomefloxacin were determined following a single 400-mg oral dose given to each of six male volunteers. Concentrations in serum, urine, and cantharidin-induced inflammatory fluid were determined by a microbiological assay. Samples from two volunteers were also assayed by high-performance liquid chromatography. The mean peak level in serum, 4.7 micrograms/ml, was attained within 1 h of administration. The mean elimination half-life from serum was 7 h. Inflammatory fluid was penetrated rapidly, with a mean peak level of 3.5 micrograms/ml occurring after 2.7 h. The mean recovery of lomefloxacin from urine over 48 h was 76% of the administered dose. There was a minor peak on the high-performance liquid chromatography trace, suggesting a small amount of unidentified metabolite. This was present only in urine; no detectable metabolites were found in serum. This study suggests that either once-daily or twice-daily dosage of lomefloxacin should be sufficient to treat urinary or systemic infections, respectively, caused by susceptible pathogens.
Rescue ICSI of oocytes that failed to extrude the second polar body 6 h post-insemination in conventional IVF.

BACKGROUND Attempts to 'rescue' by ICSI oocytes that remained unfertilized 24 h after conventional IVF have generally resulted in poor outcomes. The aim of the present study was to compare the outcome of rescue ICSI performed on one group of patients 6 h after initial insemination with those of another group where rescue ICSI was performed 22 h after initial insemination. METHODS Twenty-five patient IVF cycles provided the oocytes for rescue ICSI 6 h after initial insemination, and 20 cycles provided the oocytes for rescue ICSI 22 h after initial insemination in this retrospective study. Fertilization and cleavage rates, embryo quality, implantation, and pregnancy rates after rescue ICSI were the main outcome measures. RESULTS A fertilization rate of 70.3% was achieved with 6 h rescue ICSI compared with 48.5% with 22 h rescue ICSI (P < 0.0001). From 6 h rescue ICSI, 12 clinical pregnancies (48.0%) resulted in three sets of twins, eight singletons and one abortion. From 22 h rescue ICSI there was one (5.0%) singleton pregnancy and delivery of a healthy baby. Likewise, the implantation rate was 20.2% from 6 h rescue ICSI compared with 1.72% from 22 h rescue ICSI (P < 0.02). CONCLUSIONS Rescue ICSI after 6 h post-insemination (46 h post-HCG) gave better fertilization, pregnancy and implantation rates compared with rescue ICSI after 22 h when oocytes have become aged.
Safety of etomidate bolus administration in patients with septic shock.

Article chosen Cuthbertson BH, Sprung CL, Annane D, et al. The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 2009;35:1868-76. Study objective The authors sought to test the hypotheses that bolus doses of etomidate results in an increased proportion of nonresponders to corticotropin and an increase in mortality and that hydrocortisone treatment decreases mortality in patients receiving etomidate.
THE EFFECTS OF SIX ENVIRONMENTAL VARIABLES ON PASTEURELLA MULTOCIDA POPULATIONS IN WATER

The effects of protein, pH, temperature, sodium chloride (NaCl), clays, sucrose, and their interactions on the survival and growth of Pasteurella multocida were evaluated. Pasteurellae populations declined rapidly in waters maintained at 2 C, compared to 18 C. Increasing water soluble proteins by 175 μg/ml, and NaCl by 0.5%, greatly enhanced survival of P. multocida, whereas variations in pH, clays, and sucrose had relatively minor effects. Pasteurella multocida survived for over 1 yr in some samples of water. This is the longest known survival of these bacteria in water.
Étude expérimentale et numérique du phénomène d'enrobage dans les écoulements de coextrusion

Cette these concerne l’etude experimentale et numerique du phenomene d'enrobage dans les ecoulements de coextrusion. Dans la partie experimentale, grâce a un montage specifique developpe en partenariat avec le Cerdato, nous avons pu faire ressortir les caracteristiques suivantes, concernant la cinetique et la physique du phenomene : l'enrobage est essentiellement gouverne par la difference de viscosite entre les deux polymeres, le plus fluide enrobant son vis-a-vis. La thermique intervient dans le sens ou elle modifie la viscosite du polymere au point d'obtenir de l'auto-enrobage avec un ecart de temperature au sein de l’ecoulement. Le phenomene est surtout present aux parois puisqu'elles sont des zones a fort cisaillement, mais des essais montrent que l'on peut obtenir un enrobage dans le volume. De plus, l’etat de surface des parois ne modifie en rien la cinetique du phenomene, il n'y a donc pas de glissement local a la paroi. Dans une deuxieme partie consacree a la modelisation numerique, on montre que l'enrobage n'est pas reproduit par le calcul. Si l'on impose des conditions locales de glissement au contact paroi/ligne triple, on montre que l'on deplace localement l'interface mais dans un mouvement artificiel, non comparable a celui de l'enrobage. Nous avons donc developpe une methode originale, impliquant une modification de l’equation de transport aux parois, celle-ci n'ayant plus de signification lorsque la vitesse d’ecoulement s'annule. Par une telle approche, la simulation numerique rend compte d'un enrobage, sans imposer de glissement, les tendances generales du phenomene etant reproduites.
MANAGEMENT OF ASTHMA WITH MONTELUKAST

Respiratory tract disorder is a very common problem faced by pediatric population, asthma being one of the most common chronic disorders in young children. Many preschool children regularly wheeze, especially during common cold infection and cold seasons. Some children wheeze after a simple exercise or some after the introduction of medication like aspirin or after introduction to allergens. An anti-inflammatory therapy, consisting mainly of inhaled corticosteroids (ICs) has been the main treatment of asthma since the beginning and it still remains the first line therapy in asthma management. Since Leukotriene (LTs) are chemical mediators of airway inflammation in asthma, Leukotriene receptor antagonist (LTRAs) can be a potent anti-inflammatory drugs in the long term treatment of asthma. There are different LRTA medicines, but mainly Montelukast can be used in pediatric population, that can decrease the airway inflammation and provide bronchoprotection. The safety profile, oral administration as single daily dose and better compliance is the highlight of this drug. In this review, we describe the advances on the use of montelukast in the treatment of asthma.
Feline Immunodeficiency Virus Vif N-Terminal Residues Selectively Counteract Feline APOBEC3s

ABSTRACT Feline immunodeficiency virus (FIV) Vif protein counteracts feline APOBEC3s (FcaA3s) restriction factors by inducing their proteasomal degradation. The functional domains in FIV Vif for interaction with FcaA3s are poorly understood. Here, we have identified several motifs in FIV Vif that are important for selective degradation of different FcaA3s. Cats (Felis catus) express three types of A3s: single-domain A3Z2, single-domain A3Z3, and double-domain A3Z2Z3. We proposed that FIV Vif would selectively interact with the Z2 and the Z3 A3s. Indeed, we identified two N-terminal Vif motifs (12LF13 and 18GG19) that specifically interacted with the FcaA3Z2 protein but not with A3Z3. In contrast, the exclusive degradation of FcaA3Z3 was regulated by a region of three residues (M24, L25, and I27). Only a FIV Vif carrying a combination of mutations from both interaction sites lost the capacity to degrade and counteract FcaA3Z2Z3. However, alterations in the specific A3s interaction sites did not affect the cellular localization of the FIV Vif protein and binding to feline A3s. Pulldown experiments demonstrated that the A3 binding region localized to FIV Vif residues 50 to 80, outside the specific A3 interaction domain. Finally, we found that the Vif sites specific to individual A3s are conserved in several FIV lineages of domestic cat and nondomestic cats, while being absent in the FIV Vif of pumas. Our data support a complex model of multiple Vif-A3 interactions in which the specific region for selective A3 counteraction is discrete from a general A3 binding domain. IMPORTANCE Both human immunodeficiency virus (HIV) and feline immunodeficiency virus (FIV) Vif proteins counteract their host's APOBEC3 restriction factors. However, these two Vif proteins have limited sequence homology. The molecular interaction between FIV Vif and feline APOBEC3s are not well understood. Here, we identified N-terminal FIV Vif sites that regulate the selective interaction of Vif with either feline APOBEC3Z2 or APOBEC3Z3. These specific Vif sites are conserved in several FIV lineages of domestic cat and nondomestic cats, while being absent in FIV Vif from puma. Our findings provide important insights for future experiments describing the FIV Vif interaction with feline APOBEC3s and also indicate that the conserved feline APOBEC3s interaction sites of FIV Vif allow FIV transmissions in Felidae.
Chromosomal aberrations in Perinatal Asphyxia.

This study was conducted to evaluate the level of chromosomal damage in perinatal asphyxia and correlate it with severity of asphyxia. Fourty term neonates with asphyxia and twenty term babies without asphyxia were included in this case control study. Blood samples were collected within 24 hours of birth for karyotyping and oxidative stress by serum malondealdehyde (MDA) estimation. The degree of chromosomal damage and MDA level were significantly associated with severity of hypoxia. There was significant difference in mean frequency of chromosomal aberration and MDA level in controls ( 3.4 ± 0.280 vs 0.95±0.198 ) and cases (6.749±1.818 vs 3.687±0.156) respectively. Chromosomal aberrations also significantly correlated with Apgar score, HIE stages, seizure and serum MDA level.
MDCT evaluation of potential living renal donor, prior to laparoscopic donor nephrectomy: What the transplant surgeon wants to know?

Abstract As Laparoscopic Donor Nephrectomy (LDN) offers several advantages for the donor such as lesser post-operative pain, fewer cosmetic concerns and faster recovery time, there is growing global trend towards LDN as compared to open nephrectomy. Comprehensive pre-LDN donor evaluation includes assessment of renal morphology including pelvi-calyceal and vascular system. Apart from donor selection, evaluation of the regional anatomy allows precise surgical planning. Due to limited visualization during laparoscopic renal harvesting, detailed pre-transplant evaluation of regional anatomy, including the renal venous anatomy is of utmost importance. MDCT is the modality of choice for pre-LDN evaluation of potential renal donors. Apart from appropriate scan protocol and post-processing methods, detailed understanding of surgical techniques is essential for the Radiologist for accurate image interpretation during pre-LDN MDCT evaluation of potential renal donors. This review article describes MDCT evaluation of potential living renal donor, prior to LDN with emphasis on scan protocol, post-processing methods and image interpretation. The article laid special emphasis on surgical perspectives of pre-LDN MDCT evaluation and addresses important points which transplant surgeons want to know.
Max-Relevance and Min-Redundancy Greedy Bayesian Network Learning on High Dimensional Data

Existing algorithms for learning Bayesian network require a lot of computation on high dimensional itemsets which affects accuracy especially on limited datasets and takes up a large amount of time. To address the above problem, we propose a novel Bayesian network learning algorithm MRMRG, Max Relevance-Min Redundancy Greedy. MRMRG algorithm is a variant of K2 which is a well- known BN learning algorithm. We also analyze the time complexity of MRMRG. The experimental results show that MRMRG algorithm has much better efficiency and accuracy than most of existing algorithms on limited datasets.
Networking, collaboration, and home brewing: An exploratory study

This exploratory study contributes to the academic leisure literature, examining perceived benefits from and barriers to networking and collaboration among home brewers, employing social exchange theory (SET) and the theory of collaboration (TOCL). Sharing basic knowledge of recipes, camaraderie, and mutual support in home brewing activities were main perceived benefits, and lack of time and geographic isolation challenges of networking. Quality improvements, gains in strategic knowledge, and learning alongside others were key beneficial outcomes from collaboration; again, lack of time, and perceptions of giving more than receiving from collaboration, were main perceived challenges. Alignments between various tenets of the theories and the findings were revealed, for instance, concerning value, reward, outcome and transaction (SET), stakeholders of a problem domain and interactive process (TOCL). The study will discuss practical and theoretical implications that could be considered in and guide future leisure studies; in addition, new research avenues will be suggested.
Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease.

BACKGROUND AND PURPOSE Fodrin, a neuronal cytoskeleton protein, is proteolyzed by calpain after ischemic insult. We examined proteolysis of fodrin induced by global forebrain ischemia in gerbil hippocampus in spatial terms by using the antibody specific to the calpain-proteolyzed form of fodrin. METHODS In gerbils, a 10-minute forebrain ischemia was produced by occlusion of both carotid arteries. After recirculation, the hippocampus was processed for immunohistochemical and immunoblot study with the antibody against the calpain-proteolyzed form of fodrin. Additionally, short-term ischemia was studied to find the threshold of fodrin proteolysis. RESULTS Three phases of fodrin proteolysis distinct in chronology and distribution arose: (1) an early predegeneration phase in the molecular layer and stratum oriens of the CA1 and CA3 sectors within the first 15 minutes, which lasted up to 4 hours; (2) a late predegeneration phase in the whole CA1 sector, except for the pyramidal cells, between 12 hours and 2 days; and (3) a postdegeneration phase in the cytoplasm of the CA1 neurons, which arose in 3 to 7 days. A 4-minute (not a 3-minute) forebrain ischemia induced the late predegeneration phase of fodrin proteolysis and delayed neuronal death in CA1. Immunoblotting showed that the primary product of calpain action was further proteolyzed by an unidentified protease. CONCLUSIONS Calpain induced proteolysis of fodrin in ischemic hippocampus, and the late predegeneration phase of the proteolysis was closely associated with the delayed neuronal death in the CA1 sector. Calpain and another protease may play a role in the development of neuronal death after transient forebrain ischemia.