Miracle-dz/UniFAR-FTUs huggingface dataset:
Tissue changes of extraction sockets in humans: a comparison of spontaneous healing vs. ridge preservation with secondary soft tissue healing.

INTRODUCTION As a consequence of extraction, the height of the buccal wall tends to decrease and results in the disappearance of bundle bone. To modify bone remodelling after extraction, various ridge preservation techniques have been proposed. The present research was drawn up with the following considerations in mind: to evaluate and to compare changes of hard and soft tissues in post-extraction sockets which received a ridge preservation procedure, with post-extraction sockets which had healed naturally. MATERIALS AND METHODS Each patient was randomly allocated to a test or control group using a specific software package. After extraction, the sockets were carefully inspected and any granulation tissue was removed. The control sites received silk sutures to stabilize the clot without any grafting material. The test sites were grafted with corticocancellous porcine bone and a collagen membrane. All experimental sites had the membranes left exposed to the oral cavity with a secondary wound healing. The thickness of the buccal alveolar bone, if present, was carefully measured at the time of tooth extraction using a calliper at 1 mm from the edge of the wall. The following clinical parameters were evaluated at baseline and after 4 months at implant placement: vertical bone changes, horizontal bone changes and width of keratinized gingiva. The length, diameter and need for additional bone augmentation were assessed for both groups at the time of implant insertion. RESULTS The control group showed vertical bone resorption of 1 ± 0.7 mm, 2.1 ± 0.6 mm, 1 ± 0.8 mm and 2 ± 0.73 mm at the mesial, vestibular, distal and lingual sites respectively. Moreover, changes in horizontal dimension showed an average resorption of 3.6 ± 0.72 mm. The test sites showed a horizontal bone remodelling of 0.3 ± 0.76 mm, 1.1 ± 0.96 mm, 0.3 ± 0.85 mm, 0.9 ± 0.98 mm at the mesial, vestibular, distal and lingual sites respectively. The horizontal bone resorption at the test sites was 1.6 ± 0.55 mm. The keratinized gingiva showed a coronal shift of 0.7 mm in the control group when compared to 1.1 mm in the test group. In addition, 42% of sites in the control group required an additional bone augmentation at implant placement, when compared to 7% in the test sites. CONCLUSIONS This study clearly points out that an alveolar ridge preservation technique performed with collagenated porcine bone and a resorbable membrane--according to the procedure reported in this study--was able to limit the contour changes after tooth extraction. Finally, the test sites showed a better preservation of facial keratinized tissue when compared to control sites; grafted sites allowed the placement of longer and wider implants when compared to implants inserted in non-grafted sites.
Effect of Dietary Nucleosides on Growth and Maturation of the Developing Gut in the Rat

Dietary nucleoside (DN) as a precursor for nucleic acid synthesis may be important for rapidly dividing cells, since gut epithelial cells have limited capacity for de novo purine and pyrimidine synthesis. We evaluated in a controlled blinded study the effect of added nucleosides, 0.8% by weight, given for 2 weeks, on gut growth and maturation in 20 weanling rats. Mucosal protein and DNA in the proximal intestinal segment were 50% and 77% higher, respectively, in the DN-supplemented group (n = 10; p < 0.05). Villus height based on cell count was 25% greater in the DN group (p < 0.05). Maltase activity was significantly greater in proximal, middle, and distal intestinal segments, and the largest increase, 87%, was seen in the proximal gut mucosa. The maltase/lactase ratio was also higher in this segment. Increases in sucrase were less prominent. Lactase was minimally affected. The pattern of change in disaccharidase activity suggests that DN may enhance gut growth and maturation of the intestine in the weanling rat, the effects being more pronounced in the proximal segment. Diets free of nucleosides and nitrogenous bases may have adverse effects on the gut.
Semi-analytical formulation for the stability analysis of coexisting solutions in coupled-oscillator systems

Coupled oscillator systems with constant interstage phase shift are used for beam steering and other applications. The aim of this work is the stability investigation of the multiple mathematical solutions that coexist with the constant-phase-shift one. This will be efficiently done by means of a semi-analytical formulation, based on a perturbation model of the oscillator elements, extracted with harmonic balance. The formulation is valid for the most practical situation of weak oscillator coupling. The stability of each of the coexisting solutions is determined from the linear perturbation system, associated to the semi-analytical formulation. The presented techniques allow an in-depth understanding of the global system behavior and a conclusive determination of the instability phenomena that delimit the stable constant phase-shift ranges. The techniques have been applied to a coupled system of FET-based oscillators at 5 GHz, with very good results.
Changes in Weight Distribution at the Feet Due to Occlusal Supporting Zone Loss During Clenching

ABSTRACT To establish the relationship between the condition of the stomatognathic system and body posture, changes in the weight distribution at the feet using the four-quadrant weight scale were investigated when the occlusal supporting zone was lost unilaterally and bilaterally. The results were as follows: 1. Regardless of occlusal conditions, the weight distribution was changed during clenching; 2. The weight distribution was shifted anteriorly during clenching regardless of the condition of the occlusal supporting zone. Additionally, weight distribution shifted more laterally to the opposite side of the lost occlusal supporting zone during clenching with the occlusal supporting zone lost more unilaterally than bilaterally. From the present findings, it is suggested that the body posture may be affected and changed to an unusual position causing neck or shoulder pain, especially when the occlusal supporting zone is lost both unilaterally and bilaterally.
What Are the Barriers to Economic Self-Sufficiency of Congolese Refugees in Abilene, Texas?

Economic self-sufficiency of refugees is critical for refugees but also for the host country, given the potentially negative economic impact of refugees not attaining selfsufficiency. This study examined the predicting factors of economic self-sufficiency in a sample of 108 Congolese refugees who have lived in Abilene, Texas for over a year. This research used a quantitative method for data collection. A multiple logistic regression analysis showed that education (whether outside or inside the U.S.) and ESL attendance were the main predictors of economic self-sufficiency among the sample. This study suggests that the resettlement agencies should develop a mechanism to encourage refugees (especially the young ones) to go to school or continue their education. The results also suggest a need to develop a more effective way of implementing ESL programs for refugees who have an imminent need to work. Given the limitations of this study, the conclusion of this study should be treated with caution and verified by further studies.
Quotas for women in politics

1. Introduction to Gender Quotas 2. The Adoption of Gender Quotas 3. The Implementation of Gender Quotas 4. Reserved Seats in Pakistan and India 5. Party Quotas in Sweden and the United Kingdom 6. Legislative Quotas in Argentina and France 7. Conclusions and Directions for Future Research APPENDIX NOTES REFERENCES INDEX
Cancer statistics for african americans

Although cancer remains a major public health burden for African Americans, progress is being achieved. Since 1984, the cancer mortality rate has declined two percent. Stomach and uterine cancer death rates have shown dramatic decreases in the last 30 years. Tobacco use is declining among blacks and is much lower among black adolescents than among their white counterparts. Black women are getting Pap smears more frequently than are any other ethnic group. Evidence is now accumulating that the causes of increased cancer morbidity and mortality in African Americans are related more to poverty and lack of education and access to care than to any inherent racial characteristics. Such observations support a range of opportunities whereby the impact of cancer in African Americans can be diminished through community programs and public health action.
Pilot assessment of a radiologic classification system for segmentation defects of the vertebrae

Existing nomenclature systems for describing and reporting congenital segmentation defects of the vertebrae (SDV) are confusing, inconsistently applied, and lack molecular genetic advances. Our aim was to develop and assess a new classification system for SDV. A multidisciplinary group of the International Consortium for Vertebral Anomalies and Scoliosis (ICVAS) developed a new classification system for SDV, and 5 members group (Group 1) independently classified 10 previously unseen cases using this system. Inter‐observer reliability was assessed using kappa, which compares observed agreement with that expected by chance. Seven independent general radiologists unaffiliated with the ICVAS (Group 2) classified the same 10 cases (total, 70 scores) before and after the ICVAS system was explained. We demonstrated the following: Inter‐observer reliability for Group 1 yielded a kappa value of 0.21 (95% confidence intervals (CI) 0.052, 0.366, P = 0.0046); A consensus diagnosis was established for the 10 cases. For Group 2, before the ICVAS system was explained, 1 of 70 scores (1.4%) agreed with the Group 1 consensus diagnoses; Group 2 offered 12 different diagnoses, but 38 of 70 (54.3%) responses were “Don't Know. ” After the ICVAS system was explained, 47 of 70 responses (67.1%; 95% CI 55.5, 77.0) agreed with the Group 1 consensus, an improvement of 65.7% (95% CI 52.5, 75.6, P < 0.00005), with no “Don't Know” responses. Group 2 average reporting times, before and after explanation of the ICVAS system, were 148 and 48 min, respectively. We conclude that the ICVAS radiological classification system was found to be reliable and applicable for 10 SDV phenotypes. © 2010 Wiley‐Liss, Inc.
Detection of Helicobacter pylori DNA in Feces and Saliva by Polymerase Chain Reaction: a Review

The polymerase chain reaction (PCR), known for its high sensitivity and specificity, has been used for the detection of Helicobacter pylori DNA in bodily materials such as feces and saliva. Since fecal specimens contain PCR inhibitors, DNA before PCR amplification has been purified using various biochemical, immunological and physical pre‐PCR steps. Several PCR protocols, differing from each other in the selection of genomic targets and primers, have produced varying degrees of specificity and sensitivity in detecting H. pylori DNA. PCR identified antimicrobial resistance of H. pylori in feces. It also detected virulence factor genes such as the cytotoxin‐associated gene (cagA) and vacuolating cytotoxin gene (vacA) in feces and saliva. While the cagA gene was detected in 50–60% of fecal specimens, it was found in 25% of salivary specimens from patients. There was considerable variation in the detection rate of H. pylori DNA in salivary samples. The detection rate in saliva with the most effective primer pair was lower than that observed in feces, making saliva a less suitable specimen for the diagnosis of H. pylori infection. There is controversy regarding the permanent presence of H. pylori in saliva. Whether the salivary and gastric specimens of an individual harbor identical or different strains has not been resolved. PCR cannot distinguish between living and dead organisms. However, it can offer quick results on fecal and salivary specimens, which may contain fastidious and slow‐growing H. pylori in low numbers.
Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies.

OBJECTIVE To assess the efficacy and safety of VX-702, a p38 MAPK inhibitor, in patients with active, moderate-to-severe rheumatoid arthritis (RA). METHODS Two 12-week, double-blind, placebo-controlled studies of VX-702 were conducted in patients with active, moderate-to-severe RA. In the VeRA study, 313 patients received placebo or 2 daily doses of VX-702. In Study 304, 117 patients received placebo, daily VX-702, or twice weekly VX-702 in addition to concomitant methotrexate (MTX). Study end points included the proportion of patients meeting the American College of Rheumatology 20% improvement criteria (an ACR20 response), ACR50 and ACR70 responses, changes in the serum levels of biomarkers of inflammation, and safety assessments. RESULTS The numerically superior ACR20 response rates among patients receiving VX-702 compared with those receiving placebo in both studies did not reach pairwise statistical significance at the highest doses in either study. At week 12 in the VeRA study, ACR20 response rates were 40%, 36%, and 28% among patients receiving 10 mg of VX-702, 5 mg of VX-702, and placebo, respectively. In Study 304, the response rates were 40%, 44%, and 22% for patients receiving 10 mg VX-702 daily plus MTX, 10 mg VX-702 twice weekly plus MTX, and placebo, respectively. Reductions in the levels of C-reactive protein, soluble tumor necrosis factor receptor p55, and serum amyloid A were observed as early as week 1 in both studies, but these levels rapidly returned to baseline values by week 4. The overall frequency of adverse events was similar between the VX-702 and placebo groups. In the VeRA study, serious infections were more frequent in the VX-702 groups compared with the placebo group (2.4% versus 0%) but not in Study 304 (2.6% versus 4.9%). CONCLUSION The modest clinical efficacy plus the transient suppression of biomarkers of inflammation observed in this study suggest that p38 MAPK inhibition may not provide meaningful, sustained suppression of the chronic inflammation seen in RA.
A retrospective analysis of antidepressant poisonings in the emergency department: 11-year experience

Between 1993 and 2004, patients with antidepressant poisoning admitted to an emergency department (ED) were analysed retrospectively with regard to demographics, clinical findings and treatment attempts. Age, gender, suicide attempts, classification of antidepressants, Glasgow Coma Scale (GCS) score, ECG findings, need for endotracheal intubation, follow-up period and Antidepressant Overdose Risk Assessment (ADORA) criteria were analysed by SPSS software. A total of 356 antidepressant poisoning cases were evaluated. Tricyclic antidepressants (TCA), especially opipramol and amitriptyline, were the most common agents (58.4%). The most frequent ECG finding was sinus tachycardia (40.7%, n=145). Endotracheal intubation was required in 9.6% of cases. Patients with TCA ingestion had a longer observation time in the ED, abnormal ECG findings, abnormal physical examination findings and more ADORA criteria, than patients who ingested selective serotonin re-uptake inhibitors (SSRI) (P=0.008, P=0.008, P<0.001, P<0.001). It was found that the patients who ingested TCA (P=0.001), poisoned with amitriptyline (P=0.001), patients with GCS scores of 8 and less (P=0.001), patients with two or more ADORA criteria (P=0.001), with seizures (P=0.001), with abnormal ECG (P=0.012), and patients with a history of two or more suicide attempts were intubated more frequently. Suicide attempts, classification of the antidepressant, ECG findings, seizure, GCS score and number of detected ADORA criteria affect the need for intubation in patients with antidepressant poisoning.
Study design of the Multicultural Community Health Assessment Trial (M-CHAT): a comparison of body fat distribution in four distinct populations.

OBJECTIVE To outline the study design of the Multicultural Community Health Assessment Trial (M-CHAT). The purpose of the study is to compare the relationship between visceral adipose tissue (VAT) and total body fat in men and women of Aboriginal, Chinese, and South Asian origin with a similar group of men and women of European origin. DESIGN A total of 200 apparently healthy men and women between the ages of 30 and 65 will be recruited from each of the local Aboriginal, Chinese, and South Asian and European communities. Within each sex/ethnic group, an equal representation of participants will have a body mass index between 18.5 to 24.9, 25 to 29.9 and >30. Each participant will undergo an assessment for VAT, total body fat, metabolic risk factors, physical activity, diet, quality of life, and sociodemographics. MAIN OUTCOME MEASURES The primary outcome of this study is the relationship between VAT and total body fat in each of the Aboriginal, Chinese, and South Asian cohorts; this relationship will be compared to the European cohort after adjustment for age, sex, socioeconomic status, smoking status, physical activity, diet, and body mass index. CONCLUSIONS This study will be the first to identify differences in body fat distribution in these populations. We anticipate that in populations of Aboriginal, Chinese, and South Asian origin, a greater proportion of total body fat will be deposited as VAT compared to those of European origin.
Interoceptive ability predicts aversion to losses

Emotions have been proposed to inform risky decision-making through the influence of affective physiological responses on subjective value. The ability to perceive internal body states, or “interoception” may influence this relationship. Here, we examined whether interoception predicts participants' degree of loss aversion, which has been previously linked to choice-related arousal responses. Participants performed both a heartbeat-detection task indexing interoception and a risky monetary decision-making task, from which loss aversion, risk attitudes and choice consistency were parametrically measured. Interoceptive ability correlated selectively with loss aversion and was unrelated to the other value parameters. This finding suggests that specific and separable component processes underlying valuation are shaped not only by our physiological responses, as shown in previous findings, but also by our interoceptive access to such signals.
Effects of an experimental social stressor on resources loss, negative affect, and coping strategies

This experimental study, grounded in Hobfoll's conservation of resources (COR) theory, assessed the effects of manipulating a social stressor on loss of psychological resources, negative affect, and coping strategies. Israeli student volunteers were randomly allocated to one of two conditions: (1) social stressor (n = 66) and (2.) nonstressor (n = 59). The social stressor, aimed at reducing participant's personal resources, was experimentally induced via the Trier Social Stress Test protocol. The protocol consisted of a mock job interview administered under evaluative conditions, followed by performing a difficult arithmetic calculation task. The nonstressor condition involved a neutral interaction with an experimenter, followed by performing a relatively easy mental calculation task. Consistent with our hypotheses, the social stressor, compared to the nonstressor condition, resulted in statistically significant lower mean levels of psychological resources, higher levels of negative affect, and increased emotion-oriented and avoidance-oriented coping. Furthermore, under the social stressor condition, compared with the nonstressor condition, negative affect was more strongly related to loss of psychological resources and various coping strategies. Overall, the data provide experimental support for key tenets of COR theory
Abdominal wall repair is delayed during hepatic regeneration.

BACKGROUND Abdominal wall wound failure remains a common surgical problem. The signals that activate normal fibroplastic repair versus regeneration pathways are unknown. Transforming growth factor beta levels rise during incisional healing but fall during hepatic regeneration. Changes in the injured host cytokine milieu may therefore differentially effect abdominal wall repair versus hepatic regeneration. MATERIALS AND METHODS Forty-eight rats were divided into four groups (n = 12). Groups 1-3 underwent sham celiotomy, 70% hepatectomy, or 80% enterectomy with anastamosis. Incisions from Group 4 were treated with either 1 microg of transforming growth factor beta(2) (TGF-beta(2)) or vehicle following hepatectomy. Isolated fascial and dermal incisions were harvested and tested for breaking strength on POD 7. Serum (TGF-beta(2)) and hepatocyte growth factor (HGF) levels were measured by ELISA. RESULTS Recovery of incisional wound breaking strength was delayed following hepatectomy but not enterectomy (P<0.002). The inhibitory effect was observed in both the fascia and the dermis of the abdominal wall. TGF-beta(2) levels were depressed in hepatectomy animals on POD 7, while at the same time HGF levels were elevated. Exogenous TGF-beta(2) shifted the healing trajectory of deficient wounds back toward a control pattern. CONCLUSION Abdominal wall fascial and dermal healing is delayed during hepatic regeneration. Elevated HGF and depressed TGF-beta(2) suggest a host mechanism that prioritizes hepatic parenchymal regeneration over fibroplastic repair (scar). Observations such as these are needed as therapeutic wound healing enters the clinical realm.
Archerfish fast-start decisions can take an additional variable into account

ABSTRACT The analysis of saccadic decision-making tasks with two or four alternatives has shown what appears to be a general hallmark of decision-making: adding more alternatives decreases speed and accuracy. In their everyday lives, however, animals often select among many more than two options and under heavy constraints on speed and accuracy. Here we analyse a rapid decision made by hunting archerfish. As in the classical saccadic tasks, the fish must first estimate sensory information: based on an estimate of horizontal speed, azimuthal direction and initial height of falling prey, the fish must quickly select a suitable fast-start to arrive at the right place at the right time. Our results suggest that the fast-start decisions of archerfish are surprisingly robust with respect to adding a further decision-relevant variable. We show that the fish can appropriately account for vertical speed as an independent further variable – but the need to do so does not affect speed or accuracy of the decisions. Our findings suggest novel ways by which rapid and yet complex decisions could be balanced against increasing complexity. Summary: Speed and accuracy of a decision typically decline when the number of alternatives increases. The fast-start decisions of hunting archerfish appear to break this rule and are robust against massively increasing complexity.