Miracle-dz/UniFAR-FTUs huggingface dataset:
DESIGN OF THE c AND np CHARTS WHEN THE PARAMETERS ARE ESTIMATED

The performance of attribute control charts is usually evaluated under the assumption of known process parameters (i.e., the nominal proportion of nonconforming units or the nominal number of nonconformities). However, in practice, these process parameters are rarely known and have to be estimated from an in-control historical Phase I data set. In this paper, we investigate the number m of Phase I samples that would be necessary for the c and p charts with estimated parameters in order to obtain similar in-control ARL's as in the known parameters case. We also propose new specific chart parameters that allow the c and np charts with estimated parameters to have approximately the same in-control ARL's as the ones obtained in the known parameter case.
Hormonal treatment of vulvar vaginal atrophy (VVA): Are there options to reduce or avoid systemic adverse effects and risks?

Vulvar vaginal atrophy (VVA) is very frequent, about half of postmenopausal patients suffer from this disease. Since VVA is mainly caused by estrogen deficiency, the present first-line recommendation in guidelines is estrogen therapy. Because of the fear of systemic absorption, vaginal application is recommended if only VVA should be treated, to avoid known estrogen-dependent risks like venous thromboembolism, stroke and hormone-dependent cancer. A new alternative to estrogens is ospemifene from the class of "selective estrogen receptor modulators" (SERMs) which is thought to act selectively as an agonist on estrogen receptor alpha in the vaginal tissue. The aim of this review is to describe the conventional management using different types and dosages of vaginal estrogens and to compare with the treatment using ospemifene. Thereby the focus is on tolerability and safety issues including the official warnings in the labelings of both treatment strategies. Especially also the new concept to use "ultra-low dose" estriol alone or in fix combination with lactobacilli is highlighted, because this therapy perhaps can avoid systemic estrogenic effects although according present labeling in patients after breast cancer treatment only ospemifine can be used. Thus, this review on both treatment strategies should be important for the clinical practice. *Correspondence to: Alfred O.Mueck, Department of Women's Health University of Tuebingen, Calwer Street 7; D-72076 Tuebingen, Germany, Tel: +49 – 7071-298 4801; Fax: +49 – 7071-29 4801; E-mail: alfred.mueck@med.unituebingen. de; A.O.Mueck@t-online.de
Evaluation of atherosclerosis risk by measurement of intima media thickness and pulse wave velocity in lichen planus patients; A prospective case-control study

Amac: Liken Planus (LP) kronik inflamatuar hastaliklardan birisidir. Kronik inflamasyon subklinik ateroskleroz gelisiminde onemli bir role sahip olabilir. Bu calismamizda, LP ile ateroskleroz arasindaki iliskiyi karotis intima medya kalinligi (KIMK) ve nabiz dalga hizi (NDH) olcumlerini kullanarak arastirmayi amacladik. Yontemler: Kontrollu calisma planlandi ve LP ve kontrol grubu olmak uzere iki grup olusturuldu. Kirk LP hastasi (ortalama yasi 44.6±1.2 olan 32 bayan ve 8 erkek) ve 40 saglikli birey (ortalama yasi 41.2±0.9 olan 32 bayan ve 8 erkek) calismaya alindi. Her iki grupta da aterosklerotik risk faktorleri olan hastalar calismadan dislandi. Her iki grubun demografik ve biyokimyasal parametreleri kaydedildi. Saglikli bireyler ve LP hastalarinda KIMK ve NDH olcumleri karsilastirildi. Bulgular: Maksimum ve ortalama KIMK degerleri LP hastalarinda kontrol grubuna gore anlamli olarak daha yuksek saptandi (sirasiyla; sag maksimum KIMK; 0.77±0.01 ve 0.74±0.01 p=0.01, sol maksimum KIMK; 0.80±0.01 ve 0.76±0.01 p=0.011, sag ortalama KIMK; 0.65±0.01 ve 0.63±0.01 p=0.039, sol ortalama KIMK; 0.68±0.01 vs. 0.64±0.01, p=0.005). LP hastalari ve kontrol grubu arasinda NDH olcumleri acisindan anlamli istatistiksel farklilik gozlenmedi (sirasiyla; 6.34±0.30 ve 6.79±0.70, p=0.131). Sonuclar: Bizim calismamiza gore kalp hastaligi olmayan LP hastalarinda KIMK degerleri daha yuksek oranlarda gosterildi. LP hastalari subklinik ateroskleroza bagli vaskuler disfonksiyon ve yapisal degisiklikler acisindan risk altindadirlar.
Preventing further trauma: KINDEX mum screen - assessing and reacting towards psychosocial risk factors in pregnant women with the help of smartphone technologies

The KINDEX mum screen has been designed to be administered by gynecologists and midwives during pregnancy for the assessment of the main psychosocial developmental risk factors, which include traumatic experiences of the parents, intimate partner violence, drug abuse, a history of mental health problems, poverty, acute stress, and others. In addition, we have developed a self-assessment version that runs on tablet computers (iPads). Validation of the KINDEX has been successfully completed in Germany, Spain, Greece, and Peru. Gynecologists or midwives interviewed 80120 pregnant women in each country. A randomized sub sample of respondents was assessed by trained clinical psychologists using standardized structural interviews to assess perceived stress and mental disorders. 14-months after giving birth the new mothers were interviewed again and the predictive value of the KINDEX was assessed by structured clinical interviews and the analysis of the cortisol levels (deposited in hair over a month) of mother and child as indicator for stress. The results show that the KINDEX assesses valid information about existing risk factors through a structured 15-minute interview with the pregnant women or through the application of this instrument as self-rating on a tablet computer. The tablet computer application in addition to the paperpencil version has the advantage of automatic analysis of the data and instant recommendation for further support of the pregnant woman.
A clinico-microbiological study of diabetic foot ulcer patients to identify risk factors and their correlation with prognosis in tertiary care hospital in India -

Background: The number of diabetics in India is rising very fast and foot ulcer patients are consuming lot of hospital resources and manpower. Foot infection, leading to ulcer formation eventually leading to amputation, is totally preventable. Few studies have been done in India to predict risk factors. We studied the clinico-microbiological profile of diabetic foot ulcer patients to correlate prognosis and to identify patients who are at increased risk of amputation. Methods: 50 diabetic foot patients were assessed for age, sex, clinical presentation and routine haematological investigations. Ulcer characteristics were determined based on Wagner’s classification. Tissue samples from these patients were also cultured for infection. We studied various factors affecting healing of ulcers. We also tried to find factors predicting the need of amputation in these patients. Results: The mean age of the patients was 52.42 years. The male: female ratio is 3.5:1. The WAGNER grade of III was seen in 48% of the patients, grade I in 16%, grade II in 14%, grade IV in 14% and grade V in 8%. 100% of the patients with grade IV and V underwent amputation, while 8.3% with grade III and 4.16% with grade II had to undergo amputation and none with grade I had to receive amputation. Sixty-eight percent of these patients had been diagnosed with Diabetes for less than 10 years while the rest have been diagnosed for more than 10 years. 60% of patients were found to have peripheral neuropathy out of which 40% were sensory type and the rest were motor type. Proteus mirabilis was isolated in 80% of the patients who underwent amputation, Streptococcus pyogenes in 57%, Pseudomonas aeruginosa (50%), Klebsiella pneumonia (33%), and Staphylococcus aureus (12%). Conclusions: This study showed that male sex, smoking, above 50 years age, neuropathy and infection with Gram negative organisms are important predicting factors for developing severe foot infection in diabetics, often leading to amputation. There is a need for developing a risk assessment model in a larger prospective cohort study.
Jonathan Pieslak, Sound Targets: American Soldiers and Music in the Iraq War

‘Hopefully, you try to get the enemy to think, “Oh my God, these guys are freaking insane, look at the music they are playing”’. C.J, Grisham, US soldier in Iraq. It is one of the most famous and chilling scenes in cinema. A fleet of Hueys, assault helicopters of the 19th Airborne Cavalry, appear over the horizon at sunrise. As they approach the apparently peaceful Vietnamese village, an eerie sound can be heard above their engines and beating rotors: a kind of screaming or wailing, or perhap.
Control and test of dynamic voltage restorer on the medium voltage grid

Power quality problems like voltage dips and sags are presently important issues in the utilities. Major economic losses might appear at the customers due to those failures. This paper presents a power electronic device, which keeps voltage sags away from sensitive loads. It is a dynamic voltage restorer (DVR), which creates a series injection of voltage into the medium voltage grid. Energy storage is keeping the sensitive load running in a limited time. The design and a new control method of a DVR are explained in this paper. The DVR is also tested at medium voltage level (10 kV) and methods to initiate voltage dips are described and implemented. Different test results at 10 kV level show that the DVR keep the voltage to a sensitive load fixed in the case of voltage dips. Furthermore, it is also demonstrated that in the case of a transformer failure the system also works very fine.
Evidence based practice guidelines for the nutritional management of chronic kidney disease

The purpose of these guidelines is to provide dietitians in Australia and New Zealand with a summary of evidence based clinical guidelines related to the dietetic management of adult patients with chronic kidney disease. The patient target group is any adult patient fulfilling the definition and diagnostic criteria of Chronic Kidney Disease (CKD), excluding those with nephrotic syndrome. These guidelines by definition also exclude acute renal failure and transplantation. The clinical questions were as follows: • At what level of glomerular filtration rate (GFR) should patients be referred to the dietitian in order to maximise nutritional intervention opportunities? • Which specific measures best reflect nutritional status or change in nutritional status in CKD? • What are the goals of nutrition intervention for CKD? • What is (are) the appropriate nutritional intervention(s) to optimise nutritional status in CKD and prevent malnutrition? • What is the optimal method of implementation and follow up to ensure nutritional status is maintained or improved? These guidelines are meant to serve as a general framework for handling patients with particular health problems. It may not always be appropriate to use these guidelines to manage clients because individual circumstances may vary. The independent skill and judgement of the health care provider must always dictate treatment decisions. These guidelines for practice are provided with the express understanding that they do not establish or specify particular standards of care, whether legal, medical or other. 1
Prevalence and Quality of Life (QOL) with Premenstrual Syndrome (PMS) among the Working Women in Reproductive Age Group in Bangkok, Thailand

Background: Premenstrual syndrome (PMS) is the condition with one or more various symptoms to affect a daily life, work life, and social relationships. The symptom of PMS performs and disappears after the menstruation. The frequency of premenstrual related symptoms is approximately 80-90%. About 5% are severe symptoms which interfere with personal and social relationships. In many cases, it requires medication treatment. Many studies in Thailand were conducted among the working women in reproductive age group. Almost all data were collected from the adolescents, medical students or nurses. Therefore, this study was aimed to investigate the prevalence, factors association, and quality of life (QOL) with PMS in a different population. Methods: A cross-sectional study carried out in Bangkok from July to August 2016. Sample population was recruited from a skincare company. Data were collected by self-reported questionnaires. The descriptive statistics were evaluated by mean ± SD, percentage (n = %), odd ratio (OR), and 95% confidential interval (CI). Continuous and categorical data were analyzed by Student’s t-test and chi-square (or Fisher’s exact test) respectively. The association between factors and PMS were identified by logistic regressions. Results: One hundred and fourteen participants were recruited with mean age 34.5 ± 7.75 years. Prevalence of moderate to severe PMS was 11.4% and mild PMS/no PMS was 88.6%. Only 3 factors were associated with PMS (p 0.05). Conclusion: The prevalence of PMS among the working women in these study populations was not quite high. This study revealed the younger age had more suffer from PMS. Early screening and diagnosis might help to manage and relieve the suffering from PMS. Education, awareness, and appropriate guideline for PMS management are highly recommended to improve the QOL among the working women in reproductive age group.
Genetic biomarkers as prognostic and predictive factors in metastatic malignant melanoma

Malignant melanoma is one of the most chemoresistant malignancies in man. Although effort is put into developing new drugs to treat metastatic melanoma, still dacarbazine, an alkylating agent approved in 1975 for therapeutic use in the USA, is considered standard treatment, despite response rates as low as 10%. Today, there is no biomarker predicting response to this drug. Therefore, we have aimed at identifying such biomarkers and also prognostic markers in metastatic melanomas undergoing dacarbazine therapy. In the present papers we have revealed that metastatic melanoma patients can be classified into 4 different groups according to expression of immuneresponse, proliferative, pigmentation, and stromal genes. Most important, these classes have significant different overall survival. Further, we have identified expression of MGMT, a gene coding for an enzyme responsible for repairing DNA damage caused by alkalyting agents like dacarbazine, to predict disease stabilisation on dacarbazine treatment and to independently predict survival. In a gene known to be activated through mutation in melanomas, BRAF, we have identified alternative spliced forms where a part of the gene coding for the catalytic part of the enzyme is not included, and expression of these alternative spliced forms are correlated to response to dacarbazine treatment. In cell culture, knockdown of this gene recovered dacarbazine sensitivity in a melanoma cell line wild type (codon 600V) in BRAF, whereas a mutated cell line (codon 600E) did not respond to this knockdown. Lastly, we have shown alterations in the p53 pathway to be associated with inferior survival. If combined with low p16INK4a expression, the correlation was even stronger.
Identification of fall-risk factor degradations using quality of balance measurements

Les chutes touchent un tiers des personnes âgees de 65 ans et plus et conduit a une perte de mobilite. La detection des risques facteurs de chutes est essentielle pour une intervention precoce.Six facteurs intrinseques de chute : vision, systeme vestibulaire, amplitude articulaire, force musculaire, proprioception articulaire et plantaire ont ete evalue par des tests cliniques avant et apres une degradation temporaire. L’equilibre a ete evalue sur une plateforme de force pour le calcul de 198 parametres.Les parametres ont ete utilises comme variables pour la construction de modele de reseaux de neurones et de regression logistique avec pour objectif de diagnostiquer les deteriorations des facteurs testes. Les parametres pertinents ont ete selectionnes pour etre inclus aux modeles. Des modeles comprenant entre 3 et 10 conditions ont ete developpe, neanmoins seuls les modeles de 5 conditions et moins se sont reveles efficaces. La precision a reussi a atteindre 92% pour le modele incluant l’amplitude de la cheville, la fatigue et la vision des contrastes.Les mesures de qualite d’equilibre ont permis de detecter des deteriorations des facteurs intrinseques testes. Cependant, ces modeles ne sont efficaces qu’avec peu de conditions. Pour construire un modele performant avec plusieurs conditions il est necessaire d’inclure plus de participants lors de la construction du modele. Un outil de la sorte est interessant pour la mise en place de programmes de prevention et de reeducation
Immunological Analysis of the Alternate Rubber Crop Taraxacum koksaghyz Indicates Multiple Proteins Cross-Reactive with Hevea brasiliensis Latex Allergens

The public health risk of Type I natural rubber latex allergy, caused by residual proteins in Hevea brasiliensis rubber latex (HNRL) products, has led to some medical examination and surgeon’s gloves and other health-related products being made from synthetic polymers. However, they are generally not preferred by healthcare providers due to their physical limitations. Guayule latex (GNRL), from an alternate rubber crop Parthenium argentatum, has been proven to contain none of the protein antigens present in H. brasiliensis natural rubber latex and its products. Guayule latex has also exhibited excellent film properties. Another alternate rubber crop, Taraxacum kok-saghyz, is now under commercial development, and internet reports assume that, like guayule, its latex derived rubber is free of proteins that are cross-reactive with HNRL specific IgE antibodies. Thus, the assumption is that it will not trigger allergic reactions in Type I HNR latex allergic individuals. Using ELISA and immunoblot methods, we have tested the reactivity of HNRL protein specific murine monoclonal and polyclonal antibodies, rabbit polyclonal IgG antibodies and human IgE antibodies from clinically HNRL allergic individuals against T. kok-saghyz latex and its purified rubber particles. We demonstrate that T. kok-saghyz latex contains multiple HNRL cross-reactive proteins, which importantly react with HNRL latex specific human IgE antibodies from Type I latex allergic individuals. Exposure of HNRL allergic individuals to T. kok-saghyz latex may thus place them at risk for allergic reactions.
Cord blood and maternal total eosinophil counts in relation to infant allergy

The predictive value of raised cord blood (CB) total eosinophil counts (TEC) with regard to atopic sensitisation was studied prospectively for 1 year in 53 Black, 52 White and 57 Mixed full‐term newborns. The maternal TEC, in relation to the stress of labour, were also studied. Ethnic differences in the CB TEC were shown between the Black/White (p = 0.03) and the White/Mixed (p = 0.05) groups. The newborns sex, anatopic family history (aFH) and the method of birth had no influence on the CB TEC in any ethnic group. There were no unequivocal differences in CB TEC between those newborns who became atopic during infancy and those who did not in any of the ethnic groups, although in the Black infants, there was a marginal trend towards significance (p = 0.05). Raised CB TEC values do not, therefore, seem to be an inherited factor in terms of a predisposition for atopic disease.
The impact of social determinants of health on hospital readmissions

The current fragmented delivery of health care has contributed to unplanned hospital readmissions as a leading problem in the United States. Reducing readmissions to urban teaching hospitals is difficult. Many patients living in urban communities face social, economic, language, and transportation barriers to maintaining their health. Both the patient and the medical center experience the burden of readmission and are challenged with addressing SDoH and social injustices at several levels. Medicare views hospital readmissions as a marker representing lower quality of health care delivery to penalize hospitals providing care to the poor. This thesis addresses multiple social and economic factors associated with hospital readmissions, explores the interrelated components of readmissions at the personal and hospital system level, and delves into the interactions of bioethical principles associated with urban living. Hospital readmissions remain a serious issue nationwide and in order to reduce the rates of re-hospitalization the social and economic inequalities contributing to hospital readmissions are significant and must be addressed.
A hydraulic control system

A hydraulic control system for controlling at least one load (1; 30, 40), the respective load pressure as a load-sensing signal via a respective load-sensing line (LS - that as a means for influencing a load-sensing signal, a compensator (10) is present, a corrected load sensing signal (LS - that the compensator (10) consists of a compensation valve (11) and a shut-off valve (12), - that the compensation valve (11) comprises a pressure applied to it load-sensing pressure (p - that the shut-off valve (12) shuts the compensator (10) when at the compensation valve (11) pending load-sensing pressure (p
The acute and sub-acute toxicity of C 60 /PVP complex in vivo

The detailed study of acute and sub-acute toxicity of the complex polyvinylpyrrolidon (PVP 20 kDa)-wrapped fullerene after intraperitoneal (ip) administration was carried out on adult male Wistar rats. The value of complex was found to be 7, 8 g/kg. In sub-acute study which lasted for 30 days the rats were exposed to daily administration of the complex in the doses of 350 or 700 mg/kg. All animals survived during the study and had no significant changes in clinical signs, organ weight, hematological and biochemical parameters of blood. The electrophysiological properties of myocardium and the excretory function of kidneys remained normal. Histological analysis of liver, kidney and spleen at the end of the study also did not demonstrate toxic alterations. It was thus established that intraperitoneal administration of complex has no toxic effect. These results suggest that has no acute and sub-acute toxicity and is a perspective substance for potential application in biology and medicine.
Application of Quantitative Methods in Veterinary Epidemiology

In what case do you like reading so much? What about the type of the application of quantitative methods in veterinary epidemiology book? The needs to read? Well, everybody has their own reason why should read some books. Mostly, it will relate to their necessity to get knowledge from the book and want to read just to get entertainment. Novels, story book, and other entertaining books become so popular this day. Besides, the scientific books will also be the best reason to choose, especially for the students, teachers, doctors, businessman, and other professions who are fond of reading.