Miracle-dz/UniFAR-FTUs huggingface dataset:
Personal and Social Resources at Work: Reciprocal Relations Between Crafting for Social Job Resources, Social Support at Work and Psychological Capital

The availability and development of social and personal resources are substantial components of a positive work experience. This study aims to inquire the reciprocal relations between the personal resource of psychological capital (PsyCap; hope, self-efficacy, resilience, and optimism) and the social job resource of social support, as proposed in the job demands-resources theory. There, job crafting is defined as a catalysator to the interplay of social support and PsyCap and is therefore added to this study. Moreover, we test the enabling hypothesis of social support in the context of work. We contribute to the field, as this research (a) examines propositions of a core theory, (b) adds and extends relevant hypotheses from health psychology into occupational psychology, and (c) aims to replicate findings. To capture the dynamic nature of the selected, relevant relationships of the job demands-resources theory, we used a three-wave, 3-month panel design to study 995 employees who were working in a broad range of economic sectors and occupations. Structural equation modeling was used to test hypotheses. Results showed, that social support at work positively influenced the development of PsyCap, supporting and extending the enabling hypothesis of self-efficacy. Counterintuitively, PsyCap and crafting for social job resources were negatively related, indicating (a) that the reliance on personal resources might reduce the necessity to generate social resources, and (b) that crafting is a strategy that consumes personal resources. Previously observed gain cycles were not replicable.
High Resolution Attenuation Images From Active Seismic Data: The Case Study of Solfatara Volcano (Southern Italy)

<p>The anelastic attenuation of rocks strongly depends on the contained fluid physical state and saturation. Furthermore, it is more sensitive than elastic parameters to changes in the physical state of materials. In a geologically complex&#160; volcanic context, where fluids play a very important role, anelastic imaging of the subsoil is therefore a very powerful tool for a better understanding of its dynamics. </p><p>In this study we present a robust workflow aimed at retrieve accurate 1-D and 3-D anelastic models from the processing of active seismic data, in terms of lateral and depth variations of P-wave quality factors Q<sub>P</sub>. This methodology has been applied to data collected during a high resolution active seismic experiment in a very small-scale volcanic volume, the Solfatara crater, within Campi Flegri caldera, Southern Italy. The presented methodology is developed in three distinct steps: 1) the active seismic data have been properly processed and analyzed for measuring the t* attenuation parameter for all possible source-receivers couples. First, the source contribution has been removed by cross-correlating the recorded signal with the sweep function of the Vibroseis, which was the adopted active seismic source. Then, the spectral decay method has been applied in order to compute the t* values. 2) A reference 1-D attenuation model has been retrieved by means of a grid search procedure aiming at finding the 1-D Qp structure that minimizes the residual between the average observed t* and the theoretical t* distributions. The obtained starting reference model allowed to build a preliminary map of t* residuals through which the retrieved t* dataset has been validated. 3) The 15,296 t* measurements have been inverted by means of a linearized, perturbative approach, in a 160 x 160 x 45 m<sup>3 </sup>tomographic grid. </p><p>The retrieved 3-D attenuation model describes the first 30 m depths of Solfatara volcano as composed of very high attenuating materials, with Qp values ranging between 5 and 40. The very low Qp values, correlated with low Vp values retrieved by a previous tomographic work carried out in the area, indicate the low consolidation degree of very superficial volcanic materials of Solfatara volcano. Finally, in the NE part of the crater, lower attenuating bodies have been imaged: it is a further hint for characterizing this area of the volcano as the shallow release of the CO<sub>2 </sub>plume through the main fumaroles of the crater. </p>
Characterization of Photoluminescent Polylactone-Based Nanoparticles for Their Applications in Cardiovascular Diseases

Cardiovascular diseases (CVD) affect a large number of the population across the globe and are the leading cause of death worldwide. Nanotechnology-based drug delivery has currently offered novel therapeutic options to treat these diseases, yet combination of both diagnostic and therapeutic abilities is further needed to understand factors and/or mechanisms that affect the treatment in order to design better therapies to challenge CVD. Biodegradable photoluminescent polylactones (BPLPLs) enable to bridge this gap as these materials exhibit a stable, long-term intrinsic fluorescence as well as offers excellent cytocompatibility and biodegradability properties. Herein, we formulated three different BPLPL based nanoparticles (NPs), including BPLP-co-poly (L-lactic acid) (BPLPL-PLLA), BPLP-co-poly (lactic-co-glycolic acid) copolymers with lactic acid and glycolic acid ratios of 75:25 (BPLPL-PLGA75:25) and 50:50 (BPLPL-PLGA50:50), and extensively evaluated their suitability as theranostic nanocarriers for CVD applications. All BPLPL based NPs were <160 nm in size and had photoluminescence characteristics and tunable release kinetics of encapsulated protein model depending on polylactones copolymerized with BPLP materials. Compared to BPLPL-PLLA NPs, BPLPL-PLGA NPs demonstrated excellent stability in various formulations including deionized water, serum, saline, and simulated body fluid over 2 days. In vitro cell studies with human umbilical vein derived endothelial cells showed dose-dependent accumulation of BPLPL-based NPs, and BPLPL-PLGA NPs presented superior compatibility with endothelial cells in terms of viability with minimal effects on cellular functions such as nitric oxide production. Furthermore, all BPLPL NPs displayed hemocompatibility with no effect on whole blood kinetic profiles, were non-hemolytic, and consisted of comparable platelet responses such as platelet adhesion and activation to those of PLGA, an FDA approved material. Overall, our results demonstrated that BPLPL-PLGA based NPs have better physical and biological properties than BPLPL-PLLA; hence they have potential to be utilized as functional nanocarriers for therapy and diagnosis of CVD.
Granulocyte-Colony-Stimulating Factor Effectively Shortens Recovery Duration in Anti-Thyroid-Drug-Induced Agranulocytosis: A Systematic Review and Meta-Analysis

Background and aim: Granulocyte-colony-stimulating factor (G-CSF) is highly beneficial as a general treatment for anti-thyroid drug (ATD)-induced agranulocytosis. This meta-analysis aimed to assess the clinical effects of G-CSF and non-G-CSF on recovery duration in patients with ATD-induced agranulocytosis by analyzing the overall clinical outcomes. Methods: The PubMed, Embase, Ovid, Cochrane, Google Scholar, China National Knowledge Infrastructure (CNKI) databases were searched for published studies from 1900 to 2018. No language restriction was implemented. Results: This meta-analysis included 10 published retrospective studies and one prospective study. Data were obtained from 11 trials (474 patients: 247 with G-CSF and 227 with non-G-CSF treatment). Compared with the non-G-CSF group, the G-CSF group presented shorter recovery duration [weighted mean difference (WMD) = −3.04 days, 95% confidence interval (95% CI): −4.38 to −1.69 (Z = 4.43 P = 0.000)]. However, the recovery duration varied across regions and recovery criteria. Asian patients achieved significant clinical outcomes [WMD = −3.16 days (95% CI: −4.58 to −1.74, P = 0.000)] compared with European and South American patients [WMD = −2.19 days (95% CI: −7.38 to 3.01, P = 0.409)]. Also, according to various recovery criteria, a duration of granulocyte count increase of more than 1.5 or 1.0 × 109/L [WMD = −3.50 days (95% CI: −4.82 to −2.18, P = 0.000)] revealed a better treatment effect. Conclusion: G-CSF can significantly shorten the recovery duration in patients with ATD-induced agranulocytosis.
A Lecture in Medical Physiology- PowerPoint versus Chalkboard.

Background and objectives: Various teaching methodologies have been utilized in medical education, chalk board once was a staple of classrooms, but PowerPoints are now standard in most medical schools. Objectives were a) to understand the student perspective on the use of different teaching modes in Medical Physiology b) to rate the effectiveness of lectures by different modes of teaching. Method: A lecture in physiology was delivered to two batches of First year of Bachelor of Medicine and Bachelor of surgery (I MBBS) students. For one batch of students the lecture was delivered using PowerPoint, for the second batch of students, the same content was taught using a chalk board. A multiple choice question examination was conducted before (Pre-test) and after (Post-test) delivering the lecture. The students were given a questionnaire to choose between the chalkboard (CB) or PowerPoint (PPT) method for the various attributes. Results: It was observed that students scored better in the post-test examination, and no significant difference in score was seen between PowerPoint or chalkboard. According to the students, the attributes ―clarity of words‖ (67%), ―stress on important points‖ (52%) and ―summarizations‖ (80%) were best dealt with PowerPoint and chalk board based lectures gave better ―clarity of concepts‖ (71%), ―learning to draw diagrams‖ (67%), ―better understanding of the subject‖ (59%), ―easier note taking‖ (55%). The preferred method for delivering lectures was CB (51%). Conclusion: Lectures could be improved by utilizing a combination of both chalkboard and PowerPoint, as they each have their own advantages.
A Continuous-Flow Model for in vitro Cultivation of Mixed Microbial Populations Associated With Cystic Fibrosis Airway Infections

The airways of people with cystic fibrosis (CF) provide a nutrient-rich environment which favours colonisation by a variety of bacteria and fungi. Although the dominant pathogen associated with CF airway infections is Pseudomonas aeruginosa, it is becoming increasingly clear that inter-species interactions between P. aeruginosa and other colonists in the airways may have a large impact on microbial physiology and virulence. However, there are currently no suitable experimental models that permit long-term co-culture of P. aeruginosa with other CF-associated pathogens. Here, we redress this problem by describing a “3R’s-compliant” continuous-flow in vitro culture model which enables long-term co-culture of three representative CF-associated microbes: P. aeruginosa, Staphylococcus aureus and Candida albicans. Although these species rapidly out-compete one another when grown together or in pairs in batch culture, we show that in a continuously-fed setup, they can be maintained in a very stable, steady-state community. We use our system to show that even numerically (0.1%) minor species can have a major impact on intercellular signalling by P. aeruginosa. Importantly, we also show that co-culturing does not appear to influence species mutation rates, further reinforcing the notion that the system favours stability rather than divergence. The model is experimentally tractable and offers an inexpensive yet robust means of investigating inter-species interactions between CF pathogens.
Collaborative Database to Track Mass Mortality Events in the Mediterranean Sea

MV-L was supported by a postdoctoral contract Juan de la Cierva-Incorporacion (IJCI-2016-29329) of Ministerio de Ciencia, Innovacion y Universidades. AI was supported by a Technical staff contract (PTA2015-10829-I) Ayudas Personal Tecnico de Apoyo of Ministerio de Economia y Competitividad (2015). Interreg Med Programme (grant number Project MPA-Adapt 1MED15_3.2_M2_337) 85% cofunded by the European Regional Development Fund, the MIMOSA project funded by the Foundation Prince Albert II Monaco and the European Union's Horizon 2020 research and innovation programme under grant agreement no 689518 (MERCES). DG-G was supported by an FPU grant (FPU15/05457) from the Spanish Ministry of Education. J-BL was partially supported by the Strategic Funding UID/Multi/04423/2013 through national funds provided by FCT - Foundation for Science and Technology and European Regional Development Fund (ERDF), in the framework of the programme PT2020.
Audio-Motor Training Enhances Auditory and Proprioceptive Functions in the Blind Adult

Several reports indicate that spatial perception in blind individuals can be impaired as the lack of visual experience severely affects the development of multisensory spatial correspondences. Despite the growing interest in the development of technological devices to support blind people in their daily lives, very few studies have assessed the benefit of interventions that help to refine sensorimotor perception. In the present study, we directly investigated the impact of a short audio-motor training on auditory and proprioceptive spatial perception in blind individuals. Our findings indicate that auditory and proprioceptive spatial capabilities can be enhanced through interventions designed to foster sensorimotor perception in the form of audio-motor correspondences, demonstrating the importance of the early introduction of sensorimotor training in therapeutic intervention for blind individuals.
Maximizing the Treatment Benefit of tDCS in Neurodegenerative Anomia

We evaluated whether transcranial direct current stimulation (tDCS) in two different montages could improve picture naming abilities in participants with anomic Alzheimer Disease or Frontotemporal dementia. Methods Utilizing a double-blind cross-over design, twelve participants were trained on picture naming over a series of 10 sessions with 30 min of anodal (2 mA) tDCS stimulation to either the left inferior parietotemporal region (P3), the left dorsolateral prefrontal cortex (F3), or sham stimulation. We evaluated performance on a trained picture naming list, an equivalent novel untrained list, and additional neuropsychological tasks. Results For trained item picture naming, significantly larger improvement was seen for real stimulation vs. sham stimulation for both the DLPFC and left inferior parieto-temporal stimulation montages at the end of the stimulation sessions. The parieto-temporal montage remained superior to sham 2 weeks poststimulation. Significant improvement vs. sham was also seen for novel “untrained” item picture naming 2 weeks post-stimulation when the parieto-temporal montage was given, whereas no change was observed when the DLPFC montage was given. Finally, comparing groups when they received the parieto-temporal montage, participants with semantic variant Primary Progressive Aphasia (PPA) showed the least improvement for untrained items after their sessions. Scores on the additional neuropsychological tasks were unchanged. Conclusion tDCS stimulation has promise as a treatment for individuals with anomia arising from neurodegenerative disease, but its effectiveness can vary depending on the training given, the montage location used, as well as a participants’ diagnosis.
Attenuation Correction Approaches for Serotonin Transporter Quantification With PET/MRI

Background Several MR-based attenuation correction (AC) approaches were developed to conquer the challenging AC in hybrid PET/MR imaging. These AC methods are commonly evaluated on standardized uptake values or tissue concentration. However, in neurotransmitter system studies absolute quantification is more favorable due to its accuracy. Therefore, our aim was to investigate the accuracy of segmentation- and atlas-based MR AC approaches on serotonin transporter (SERT) distribution volumes and occupancy after a drug challenge. Methods 18 healthy subjects (7 male) underwent two [11C]DASB PET/MRI measurements in a double-blinded, placebo controlled, cross-over design. After 70 min the selective serotonin reuptake inhibitor (SSRI) citalopram or a placebo was infused. The parameters total and specific volume of distribution (VT, VS = BPP) and occupancy were quantified. All subjects underwent a low-dose CT scan as reference AC method. Besides the standard AC approaches DIXON and UTE, a T1-weighted structural image was recorded to estimate a pseudo-CT based on an MR/CT database (pseudoCT). Another evaluated AC approach superimposed a bone model on AC DIXON. Lastly, an approach optimizing the segmentation of UTE images was analyzed (RESOLUTE). PET emission data were reconstructed with all 6 AC methods. The accuracy of the AC approaches was evaluated on a region of interest-basis for the parameters VT, BPP, and occupancy with respect to the results of AC CT. Results Variations for VT and BPP were found with all AC methods with bias ranging from −15 to 17%. The smallest relative errors for all regions were found with AC pseudoCT (<|5%|). Although the bias between BPP SSRI and BPP placebo varied markedly with AC DIXON (<|12%|) and AC UTE (<|9%|), a high correlation to AC CT was obtained (r2∼1). The relative difference of the occupancy for all tested AC methods was small for SERT high binding regions (<|4%|). Conclusion The high correlation might offer a rescaling from the biased parameters VT and BPP to the true values. Overall, the pseudoCT approach yielded smallest errors and the best agreement with AC CT. For SERT occupancy, all AC methods showed little bias in high binding regions, indicating that errors may cancel out in longitudinal assessments.
A Two-Dimensional Axisymmetric Finite Element Analysis of Coupled Inertial-Viscous-Frictional-Elastic Transients in Magnetorheological Dampers Using the Compressible Herschel-Bulkley Fluid Model

It has been challenging to accurately predict the unique characteristics of magnetorheological (MR) dampers, due to their inherent nonlinear nature. Multidimensional flow simulation has received increasing attentions because it serves as a general methodology for modelling arbitrary MR devices. However, the compressibility of MR fluid which greatly affects the hysteretic behavior of an MR damper is neglected in previous multidimensional flow studies. This paper presents a two-dimensional (2D) axisymmetric flow of the compressible Herschel-Bulkley fluid in MR dampers. We simulated the fully coupled inertial-viscous-frictional-elastic transients in MR dampers under low-, medium- and high frequency excitations. An arbitrary Lagrangian-Eulerian kinematical description is adopted, with the piston movements represented by the moving boundaries. The viscoplasticity and compressibility of MR fluid are respectively modeled by the modified Herschel-Bulkley model and the Tait equation. The streamline-upwind Petrov–Galerkin finite element method is used to solve the model equations including the conservation laws and mesh motion equation. We tested the performances of an MR damper under different electric currents and different frequency displacement excitations, and the model predictions agree well with the experimental data. Results showed that the coupled transients of an MR damper are frequency dependent. The weak compressibility of MR fluid, which mainly happens in the chamber rather than in the working gap, is crucial for accurate predictions. A damper’s transition from the pre-yield to the post-yield is essentially a step-response of a second order mass-spring-viscous system, and we give such step-response a detailed explanation in terms of mass flow rate.
Response: Commentary: Directions for Optimization of Photosynthetic Carbon Fixation: RuBisCO’s Efficiency May Not Be So Constrained After All

Understanding the molecular mechanisms that make enzymes work remains one of the grand challenges in contemporary biophysics. If this understanding can be translated into the successful re-engineering of enzymes with greater efficiency, the practical benefits could be enormous. One such enzyme that has been targeted for re-engineering, ribulose 1,5-bisphosphate carboxylase/ oxygenase (Rubisco, EC 4.1.1.39), is of intensive interest in agriculture and related fields as it fixes CO2 in higher plants and the vast majority of other photosynthetic organisms. In a recent article, Cummins et al. (2018a), we presented a statistical analysis of a wide range of published kinetic data on Rubisco. The results of that study suggested evidence of significant rates of decarboxylation (reaction with CO2) and deoxygenation (from the side reaction of Rubisco with O2) among wild-type Rubiscos. These results have challenged the accepted view that dissociation of the gas molecules (decarboxylation and deoxygenation) from the enzyme complex is negligible in all wildtype Rubiscos. In a commentary on Cummins et al. (2018a), Tcherkez et al. (2018) have contested our conclusion of significant decarboxylation and deoxygenation rates in Rubisco and suggested it is based on a misinterpretation of “implicit relationships between Rubisco rate constants” and “overlooks experimental evidence for feeble rates of deoxygenation and decarboxylation. ” In this response to their commentary on Cummins et al. (2018a), we address these criticisms.
Induction of Intestinal Th17 Cells by Flagellins From Segmented Filamentous Bacteria

T-helper-17 (Th17) cells are a subset of CD4+ T cells that can produce the cytokine interleukin (IL)-17 and play vital roles in protecting the host from bacterial and fungal infections, especially at the mucosal surface. These are abundant in the small intestinal lamina propria (SILP) and their differentiation are associated with the colonization of the intestinal flora. Segmented filamentous bacteria (SFB) drew the attention of researchers due to their unique ability to drive the accumulation of Th17 cells in the SI LP of mice. Recent work has highlighted that SFB used microbial adhesion-triggered endocytosis (MATE) to transfer SFB antigenic proteins into small intestinal epithelial cells (SI ECs) and modulate host immune homeostasis. However, which components of SFB are involved in this immune response process remains unclear. Here, we examined the roles of SFB flagellins in Th17 cells induction using various techniques, including ELISA, ELISPOT, and RNA-seq in vitro and in vivo. The results show that the immune function of SFB flagellins is similar to SFB, i.e., induces the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the SI LP. Furthermore, treatment of mice with SFB flagellins lead to a significant increase in the expression of genes associated with the IL-17 signaling pathway, such as IL-6, IL-1β, TNF-α, IL-17A, IL-17F, and IL-22. In addition, SFB flagellins have an intimate relationship with intestinal epithelial cells, influencing the expression of epithelial cell-specific genes such as Nos2, Duox2, Duoxa2, SAA3, Tat, and Lcn2. Thus, we propose that SFB flagellins play a significant role in the involvement of SFB in the induction of intestinal Th17 cells.