Miracle-dz/UniFAR-FTUs huggingface dataset:
Phylogeography of the Rhabditis (Pellioditis) marina species complex: evidence for long‐distance dispersal, and for range expansions and restricted gene flow in the northeast Atlantic

Pinpointing processes that structure the geographical distribution of genetic diversity of marine species and lead to speciation is challenging because of the lack of obvious dispersal barriers and the likelihood of substantial (passive) dispersal in oceans. In addition, cryptic radiations with sympatric distributions abound in marine species, challenging the allopatric speciation mechanism. Here, we present a phylogeographical study of the marine nematode species complex Rhabditis (Pellioditis) marina to investigate processes shaping genetic structure and speciation. Rhabditis (P.) marina lives on decaying macroalgae in the intertidal, and may therefore disperse over considerable distances. Rhabditis (P.) marina consists of several cryptic species sympatrically distributed at a local scale. Genetic variation in the COI gene was screened in 1362 specimens from 45 locations around the world. Two nuclear DNA genes (ITS and D2D3) were sequenced to infer phylogenetic species. We found evidence for ten sympatrically distributed cryptic species, seven of which show a strong genetic structuring. A historical signature showed evidence for restricted gene flow with occasional long‐distance dispersal and range expansions pre‐dating the last glacial maximum. Our data also point to a genetic break around the British Isles and a contact zone in the Southern Bight of the North Sea. We provide evidence for the transoceanic distribution of at least one cryptic species (PmIII) and discuss the dispersal capacity of marine nematodes. The allopatric distribution of some intraspecific phylogroups and of closely related cryptic species points to the potential for allopatric speciation in R. (P.) marina.
Ferric carboxymaltose increases epoetin-α response and prevents iron deficiency before elective orthopaedic surgery.

Mots-clés Aged [6], Drug Synergism [7], Erythropoietin/therapeutic use [8], Female [9], Ferric Compounds/therapeutic use [10], Hematinics/therapeutic use [11], Hemoglobins/metabolism [12], Humans [13], Iron/blood/deficiency [14], Male [15], Maltose/analogs & derivatives/therapeutic use [16], Middle Aged [17], Orthopedic Procedures/methods [18], Preoperative Care [19], Recombinant Proteins/therapeutic use [20], Surgical Procedures, Elective [21] URL de la notice http://okina.univ-angers.fr/publications/ua8251 [22] DOI 10.1093/bja/aeu245 [23] Lien vers le document http://dx.doi. org/10.1093/bja/aeu245 [23] Titre abrégé Br J Anaesth
PENGARUH RASIO INDIKATOR TINGKAT KESEHATAN BANK TERHADAP PERTUMBUHAN LABA PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BEI PERIODE TAHUN 2009-2013

Penelitian ini dilakukan untuk menguji pengaruh rasio indikator tingkat kesehatan bank terhadap pertumbuhan laba. Rasio indikator tingkat kesehatan bank yang diuji yaitu CAR (Capital Adequacy Ratio), NIM (Net Interest Margin), NPL (Non Performing Loan), NPM (Net Profit Margin), BOPO (Biaya Operasional Pendapatan Operasional), LDR (Loan to Deposit Ratio. Data yang digunakan adalah laporan tahunan perbankan yang terdaftar di BEI yang dipublikasikan selama periode pengamatan tahun 2009-2013. Populasi yang digunakan dalam penelitian ini adalah semua perusahaan perbankan yang terdaftar di BEI tahun 2009-2013. Teknik sampling yang digunakan adalah purposive sampling. Diperoleh jumlah sampel sebanyak 13 perusahaan. Teknik analisis data yang digunakan adalah regresi linier berganda dan uji hipotesis menggunakan t-statistik untuk menguji koefisien regresi parsial serta F-statistik. Selain itu juga dilakukan uji asumsi klasik yang meliputi uji normalitas, uji multikolinearitas, uji heteroskedastisitas dan uji autokorelasi. Dari hasil uji hipotesis secara parsial (uji t) menunjukkan bahwa variabel CAR berpengaruh signifikan terhadap pertumbuhan laba. Sedangkan variabel NIM, NPL, NPM, BOPO dan LDR tidak berpengaruh signifikan terhadap pertumbuhan laba. Kata kunci: rasio indikator tingkat kesehatan bank, pertumbuhan laba.
The Effectiveness of Brand- and Customer-Centric Content Strategies at Generating Shares, ‘Likes’, and Comments

ABSTRACT Brands are constantly competing for user attention on Facebook and are trying to encourage fans to share, click ‘like’, and comment their posts. Yet, it remains unclear what content strategies are successful at encouraging those behaviors. Noting that the effectiveness of brand content strategies still remains an uncharted research area, this study adopts a discovery-oriented approach and employs workshops, quantitative content analysis, and episodic interviews, to link desired user responses (namely clicks share, ‘like’, and comment) to brand content strategies. This study reveals that customer-centric content strategies are the most effective at encouraging user responses. Managers can use provided recommendations to engage their customers by adopting content strategies that result in desired behavioral reactions.
Trends in Antibiotic Resistance Pattern among Escherichia coli Isolates from Patients with Urinary Tract Infection in Tertiary Care Hospital, Bellary

To study the prevalence rate and to determine the resistance pattern among Escherichia coli isolates to commonly used antibiotics from patients having Urinary tract infections (UTI) and to determine Extended spectrum beta lactamase (ESBL) producers among them and their sensitivity pattern. Out of 580 urine samples processed from patients with urinary tract infection during a study period of six months, 303 samples yielded growth on culture out of which Escherichia coli (E. coli) was found to be the commonest isolate accounting for 39.6% (n=120), whereas 183 samples yielded bacteria and fungi other than E. coli. All the E. coli isolates were subjected for antibiotic sensitivity testing by Kirby Bauer disk diffusion method on Muller Hinton Agar in accordance with CLSI guidelines. Out of the 12 antibiotics tested against E. coli isolates, amoxycillin (100%) , fluoroquinolones [ciprofloxacin (95.8%), norfloxacin (91.7%), ofloxacin (96.7%)], third generation cephalosporins [ceftazidime (91.7%), ceftriaxone (94.2%), cefotaxime (97.5%)], showed the highest resistance, followed by cotrimoxazole (66.7%), piperacillin-tazobactum (55.8%) and amikacin (39.2%), while least resistance was shown by imipenem (5.9%) and nitrofurantoin (21.7%). Moreover our study identified 26 E. coli isolates (21.6%) to be extended spectrum beta lactamases (ESBL) producers by Double disc diffusion synergy test (DDST). All ESBL E. coli were resistant to ceftazidime, cotrimoxazole and amoxicillin whereas sensitive to imipenem. Highest number of ESBL producers was detected by ceftazidime. E. coli were found to be the commonest causative agent of UTI in our study showing co-resistance to many classes of antibiotics. The study concluded that nitrofurantoin could be recommended for empirical therapy in UTI patients in our region.
Extending the UTAUT Model to Understand the Citizens’ Acceptance and Use of Electronic Government in Developing Country: A Structural Equation Modeling Approach

The rapid development of information and communication technologies had a positive impact on the government to provide better and efficient services to the community. Despite some criticisms of electronic government services (e-gov), its utilization has continued to improve. The citizens need to be placed as customers at the center of the development and provision of public services. User satisfaction may indeed have the decisive influence in adopting and using egov services. This research modifies unified theory of acceptance and use of technology (UTAUT) model to improve user satisfaction and provide a solution for governments and to rethink the strategy for presenting a better model. A quantitative study has been conducted to describe the model and formulate sufficient indicators to measure user satisfaction. Furthermore, the measurement model was tested using the data from the questionnaire. Structural equation modeling (SEM) was applied to discover the goodness of fit underlying models and indicators. Based on the results, we find that privacy and performance expectancy showed positive performance effects on the intention to use e-gov services. Finally, the results of this study are also expected to be an input for stakeholders for the development of egov in the future. Keywords; e-government; UTAUT; SEM; PLS; Public Services; Adoption
BOARD STRUCTURE AND EARNINGS MANAGEMENT: EVIDENCE OF SOUTH EAST ASIA COUNTRIES CATEGORISED BY AGENCY COST LEVEL

Agency theory infers that investors will incur cost to make alignment on principal-agent interest. A critic, however, has pointed out that the conflict of interest between principal and agent is not the only cause for agency cost. Cultural context (Johnson & Droege, 2004) and legal system (La Porta, et al., 2000) are also found as contributing factors. This study is to empirically investigate how board size, board independency, audit committee size and audit committee independency affect the earnings quality in the context of low or high level agency cost country according to Transparency International’s corruption level and Hofstede’s cultural values. 538 firm-year across 6 South East Asian countries (Indonesia, Malaysia, Philippines, Singapore, Thailand, and Vietnam) are observed in this research. Five Different accrual models (Jones, 1991; Dechow, Sloan, & Sweeney, Detecting Earnings Management, 1995; Kasznik, 1999; Dechow, Richardson, & Tuna, Earnings management and costs to investors from firms meeting or slightly exceeding benchmarks, 2002; Dechow & Dichev, The Quality of Accruals and Earnings: The Role of Accrual Estimation Errors, 2002) are used to generate abnormal accruals which will be used as proxy for earnings management while to generate suitable factors from corporate governance variables, principal component analysis (PCA) is employed. Results indicate that (1) earnings management is efficient; (2) size and independency of Board of Director and audit committee are effective in reducing earnings management behaviour; (3) the management of firms operating in higher agency cost context will take advantage from the structure of corporate governance (size and independency of Board of Directors and audit committee) to conduct earnings management. Additionally, it is also found that bigger size (higher leverage) firms perform less (more) accounting discretion compared to their counterparts.
Interaural Time and Level Difference Thresholds for Acoustically Presented Signals in Post-Lingually Deafened Adults Fitted with Bilateral Cochlear Implants Using CIS+ Processing

Objectives: The main purpose of the study was to measure thresholds for interaural time differences (ITDs) and interaural level differences (ILDs) for acoustically presented noise signals in adults with bilateral cochlear implants (CIs). A secondary purpose was to assess the correlation between the ILD and ITD thresholds and error scores in a horizontal-plane localization task, to test the hypothesis that localization by individuals with bilateral implants is mediated by the processing of ILD cues. Design: Eleven adults, all postlingually deafened and all bilaterally fitted with MED-EL COMBI 40+ CIs, were tested in ITD and ILD discrimination tasks in which signals were presented acoustically through headphones that fit over their two devices. The stimulus was a 200-msec burst of Gaussian noise bandpass filtered from 100 to 4000 Hz. A two-interval forced-choice adaptive procedure was used in which the subject had to respond on each trial whether the lateral positions of the two sound images (with the interaural difference favoring the left and right sides in the two intervals) moved from left-to-right or right-to-left. Results: In agreement with previously reported data, ITD thresholds for the subjects with bilateral implants were poor. The best threshold was ∼400 &mgr;sec, and only five of 11 subjects tested achieved thresholds <1000 &mgr;sec. In contrast, ILD thresholds were relatively good; mean threshold was 3.8 dB with the initial compression circuit on the implant devices activated and 1.9 dB with the compression deactivated. The ILD and ITD thresholds were higher than previously reported thresholds obtained with direct electrical stimulation (generally, <1.0 dB and 100 to 200 &mgr;sec, respectively). When the data from two outlying subjects were omitted, ILD thresholds were highly correlated with total error score in a horizontal-plane localization task, computed for sources near midline (r = 0.87, p < 0.01). Conclusions: The higher ILD and ITD thresholds obtained in this study with acoustically presented signals (when compared with prior data with direct electrical stimulation) can be attributed—at least partially—to the signal processing carried out by the CI in the former case. The processing strategy effectively leaves only envelope information as a basis for ITD discrimination, which, for the acoustically presented noise stimuli, is mainly coded in the onset information. The operation of the compression circuit reduces the ILDs in the signal, leading to elevated ILD thresholds for the acoustically presented signals in this condition. The large magnitude of the ITD thresholds indicates that ITDs could not have contributed to the performance in the horizontal-plane localization task. Overall, the results suggest that for subjects using bilateral implants, localization of noise signals is mediated entirely by ILD cues, with little or no contribution from ITD information.
Spatial Learning Activates Neural Cell Adhesion Molecule Polysialylation in a Corticohippocampal Pathway Within the Medial Temporal Lobe

Abstract: Transient and time‐dependent modulations of neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus of the rodent hippocampus are a feature of spatial and nonspatial forms of learning. In the hippocampal formation, polysialic acid immunoreactivity was localized to granule‐like cells and their mossy fibre axons. We now demonstrate the latter to extend to the CA3 region where apparent recurrent and Schaffer collaterals were labelled. The axons of the CA1 pyramidal cell layer were immunopositive, as was the subiculum that they innervate. Layers I and III of the entorhinal cortex stained intensely for polysialic acid; however, these were not visible in the more lateral aspect of this region and were replaced by a single band of immunopositive neurons that extended to include the perirhinal and piriform cortices. After Morris water maze training, the number of polysialylated neurons within the entorhinal cortex exhibited a two‐ to threefold increase at the 10–12‐h posttraining time with respect to that observed immediately after training. This increase was task specific, as no change was observed in freely swimming animals or those required to locate a visible platform. These results suggest the presence of a corticohippocampal pathway involved in the eventual consolidation of memory.
The Influence of Destination Image on Tourist Intention and Decision to Visit Tourist Destination (A Case Study of Pemuteran Village in Buleleng, Bali, Indonesia)

This study examines the effects of the destination image to tourist intention and decision to visit tourism destination in Pemuteran Village, Bali. Destination image is an independent variable, tourist intention to visit serves as an intervening variable and decision to visit is a dependent variable. Explanatory research with quantitative method is employed. The number of sample is 112 respondents. Purposive sampling techniques is applied with criteria of Pemuteran village tourists. Data are collected with questionnaires and processed with path analysis. These results indicate that the variable destination image has a direct and significant effect on tourist intention to visit by 11.3%. Variable destination image has a direct and significant influence on the decision to visit by 37.5%. Variable tourist intention to visit has been direct and significant influence on the decision to visit amounted to 16.2%. Based on these results, Pemuteran village should keep trying to build a positive image and to improve the communication between the local government and local communities to strengthen cooperation to improve the natural environment in Pemuteran village.
The Disseminative Capability of the Sources in Cross-Border Knowledge Transfer Process: A Case Study of a Franco-Japanese Joint Venture in Brazil

The objective of this research was to examine the contribution of the disseminative capability of the sources in the knowledge transfer between two international mother companies and a joint venture installed in Brazil. Successful research on international knowledge transfer generally emphasises the absorptive capability of the receivers and other factors, while the role of the knowledge source(s) has been neglected. Considering this gap, the literature review synthesised the main attributes related to the source’s disseminative capability in the knowledge transfer process, among them, the ability to transfer and the motivation to engage in the process. The joint venture involved representatives of companies based in France and Japan. A qualitative, longitudinal cross-sectional approach was used. This methodology afforded a unique opportunity to examine the phenomenon of the cross-border knowledge transfer process from the perspective of the sources. The results suggest that, in terms of the knowledge transfer capability, the sources used experiences from other projects, experienced expatriates and the exploitation of social integration mechanisms, which allowed satisfactory results concerning the knowledge transfer. Regarding the motivation to transfer, the enthusiasm of the sources was more significant in the initial phases.
The Mediating Role of Quality Services in the Relationship between Internal Marketing and Customer Satisfaction

This study was conducted in 2016 with the aim of studying the mediating role of quality services in the relationship between state marketing and customer satisfaction. The population of this study includes all staff and customers of Melli Bank of Shiraz; that among these, 150 people were selected by simple random sampling method. Reliability was confirmed by Cronbach's alpha and composite reliability, and validity of the technical content validity, construct validity - convergent and divergent. Using structural equation modeling technique, the research hypotheses were tested. First, the quality of measurement and structural models were investigated, the results showed that both models are a favorable fitness. This finding showed that the use of internal marketing has a significant impact on improving the quality of service. The impact of service quality improvement organization has a significant impact on increasing customer satisfaction. Also, the impact of direct, indirect and overall of internal marketing has a significant impact on increasing customer satisfaction.
Innovativeness as a driver of the international expansion of developing markets’ firms: Evidence of curvilinear effects

The purpose of this paper is to examine the curvilinear effects of firm innovativeness (i.e. product, organisational and marketing innovation) on international expansion as well as the effect of expansion on performance in the developing countries (DCs) setting. ,Research hypotheses are tested using survey data obtained from firms located in four South-East European DCs. Covariance-based structural equation modelling is used to test the proposed conceptual framework. ,Empirical findings support the hypothesised U-shaped relationship between product innovation and organisational innovation and the level of international expansion of firms in developing markets. The authors found an inverse U-shaped relationship between marketing innovation and the level of international expansion. Furthermore, the existence of a strong positive link between the level of international expansion and firm performance is also confirmed. ,While this research utilises a sample of firms from a homogenous group of DCs, further research could use a more heterogeneous sample and thus control the model for various contingency effects (e.g. environment turbulence, market structure and competitive dynamics). ,When it comes to product and organisational innovation, international expansion is achieved only with a higher level of innovativeness. On the contrary, beyond a certain level, further investments in marketing innovation do not have additional positive effects on international expansion. ,This study is one of the first that explicitly focuses on examining the non-linear effects of innovativeness on international expansion in the DC context.
Structural consequences of histidine phosphorylation: NMR characterization of the phosphohistidine form of histidine-containing protein from Bacillus subtilis and Escherichia coli.

The bacterial phosphoenolpyruvate:sugar phosphotransferase system involves a series of reactions in which phosphoprotein intermediates are formed. Histidine-containing protein (HPr) is phosphorylated on the N delta 1 position of the imidazole ring of His15 by enzyme I and acts as a phosphoryl donor to the sugar-specific enzymes IIA. The structure of phosphorylated HPr from Bacillus subtilis, primarily, and from Escherichia coli has been studied by nuclear magnetic resonance (NMR) spectroscopy. Phosphorylation of His15 results in large downfield shifts in amide proton and nitrogen resonances for residues 16 and 17 but results in only modest or no shifts in other backbone resonances. The exchange rates of these two amide groups are decreased more than 10-fold upon phosphorylation. Analysis of the coupling constants 3JNH alpha revealed no significant changes throughout the protein, indicating that backbone phi dihedral angles do not change detectably. 3J alpha beta and 3JN beta patterns determined from P.E. COSY and HNHB spectra, respectively, revealed a change in one side chain, that of conserved Arg17. Analysis of NOESY spectra revealed a limited number of changes in NOEs involving protons in Ser12, His15, Arg71, and Pro18 in B. subtilis HPr. The NMR results indicate that the Arg17 side chain becomes limited in its conformational range in the phosphorylated protein, taking on a conformation that points its guanidinium group toward the phosphoryl group on His15. In addition, the tautomeric and ionization states of His15 have been determined using 15N and 31P NMR. At neutral pH, the imidazole is predominantly in the protonated form and the phosphoryl group is in the dianionic form in P-His15. Altogether, the results indicate that phosphorylation of His15 yields only a local effect on the protein's structure. The data are consistent with a small change in the disposition of the histidine side chain, allowing phosphoryl group oxygens to serve as hydrogen bond acceptors for the amide protons of residues Ala16 and Arg17, which constitute the first two residues of an alpha-helix. Thus, similar to many proteins that bind phosphoryl moieties noncovalently, the phosphoryl group in P-His15-HPr is situated to allow for a favorable electrostatic interaction at the N-terminal end of an alpha-helix.