Miracle-dz/UniFAR-FTUs huggingface dataset:
Dung beetle assemblages (Coleoptera, Scarabaeinae) in Atlantic forest fragments in southern Brazil

Dung beetle assemblages (Coleoptera, Scarabaeinae) in Atlantic forest fragments in southern Brazil. The beetles of the subfamily Scarabaeinae are important organisms that participate in the cycle of decomposition, especially in tropical ecosystems. Most species feed on feces (dung) or carcasses (carrion) and are associated with animals that produce their food resources. Dung beetles are divided into three functional groups: rollers, tunnelers and dwellers. This present work aims to study the diversity of dung beetle communities inhabiting fragments of the Atlantic Forest, with the purpose of describing the ecology of the species in southern Brazil. This study was conducted in the region of Campos Novos, in Santa Catarina, where twenty sites of Atlantic forest fragments were sampled. Samplings of dung beetles were conducted using 200 pitfall traps, of which 100 were baited with human feces and another 100 with carrion. Size and environmental complexity were also measured for each forest fragment. A total of 1,502 dung beetles, belonging to six tribes, 12 genera and 33 species, were collected. Results of the Levin's index of niche breadth indicated that 11 species were categorized as being coprophagous, ten as generalists, and two as necrophagous. Most species are tunnelers (19), nine of rollers and four of dwellers. The great diversity of Scarabaeinae in the region of Campos Novos, including several rare species, adds important data to the Scarabaeinae fauna in the central-western region of Santa Catarina. It may also help choosing priority areas for conservation in the region, where human impact, with large areas of monoculture, increasingly threatens the fragments of Mixed Ombrophilous Forest.
The relations between psychosocial factors at work and health status among workers in home care organizations

A considerable proportion of sickness absence and disability pension is caused by subjective health complaints, especially low back pain (LBP). In recent years focus has been on psychosocial characteristics of work as potential risk factors. The aim of this study is to examine the relations between psychosocial work aspects and subjective health complaints, LBP, and need for recovery. A total of 779 employees working in home care participated in a cross-sectional study. Higher psychological demands were associated with subjective health complaints and need for recovery. However, decision authority, skill discretion, and the 2 aspects of social support did not seem to be important factors. Higher psychological demands do not seem to be associated with severity of LBP, but does show an association with sick leave.
ISCCP cloud properties associated with standard cloud types identified in individual surface observations

Individual surface weather observations from land stations and ships are compared with individual cloud retrievals of the International Satellite Cloud Climatology Project (ISCCP), stage C1, for an 8-yr period (1983‐ 91) to relate cloud optical thicknesses and cloud-top pressures obtained from satellite data to the standard cloud types reported in visual observations from the surface. Each surface report is matched to the corresponding ISCCP-C1 report for the time of observation for the 280 km 3 280 km grid box containing that observation. Classes of the surface reports are identified in which a particular cloud type was reported present, either alone or in combination with other clouds. For each class, cloud amounts from both surface and C1 data, base heights from surface data, and the frequency distributions of cloud-top pressure ( pc) and optical thickness (t ) from C1 data are averaged over 158 latitude zones, for land and ocean separately, for 3-month seasons. The frequency distribution of pc and t is plotted for each of the surface-defined cloud types occurring both alone and with other clouds. The average cloud-top pressures within a grid box do not always correspond well with values expected for a reported cloud type, particularly for the higher clouds Ci, Ac, and Cb. In many cases this is because the satellites also detect clouds within the grid box that are outside the field of view of the surface observer. The highest average cloud tops are found for the most extensive cloud type, Ns, averaging 7 km globally and reaching 9 km in the ITCZ. Nimbostratus also has the greatest average retrieved optical thickness, t 20. Cumulonimbus clouds may actually attain far greater heights and depths, but they do not fill the grid box. The t ‐p c distributions show features that distinguish the high, middle, and low clouds reported by the surface observers. However, the distribution patterns for the individual low cloud types (Cu, Sc, St) occurring alone overlap to such an extent that it is not possible to distinguish these cloud types from each other on the basis of t ‐p c values alone. Other cloud types whose t ‐p c distributions are indistinguishable are Cb, Ns, and thick As. However, the t ‐p c distribution patterns for the different low cloud types are nevertheless distinguishable when all occurrences of a low cloud type are included, indicating that the different low types differ in their probabilities of co-occurrence with middle and high clouds.
VimA-Dependent Modulation of Acetyl Coenzyme A Levels and Lipid A Biosynthesis Can Alter Virulence in Porphyromonas gingivalis

ABSTRACT The Porphyromonas gingivalis VimA protein has multifunctional properties that can modulate several of its major virulence factors. To further characterize VimA, P. gingivalis FLL406 carrying an additional vimA gene and a vimA-defective mutant in a different P. gingivalis genetic background were evaluated. The vimA-defective mutant (FLL451) in the P. gingivalis ATCC 33277 genetic background showed a phenotype similar to that of the vimA-defective mutant (FLL92) in the P. gingivalis W83 genetic background. In contrast to the wild type, gingipain activity was increased in P. gingivalis FLL406, a vimA chimeric strain. P. gingivalis FLL451 had a five times higher biofilm-forming capacity than the parent strain. HeLa cells incubated with P. gingivalis FLL92 showed a decrease in invasion, in contrast to P. gingivalis FLL451 and FLL406, which showed increases of 30 and 40%, respectively. VimA mediated coenzyme A (CoA) transfer to isoleucine and reduced branched-chain amino acid metabolism. The lipid A content and associated proteins were altered in the vimA-defective mutants. The VimA chimera interacted with several proteins which were found to have an LXXTG motif, similar to the sorting motif of Gram-positive organisms. All the proteins had an N-terminal signal sequence with a putative sorting signal of L(P/T/S)X(T/N/D)G and two unique signatures of EXGXTX and HISXXGXG, in addition to a polar tail. Taken together, these observations further confirm the multifunctional role of VimA in modulating virulence possibly through its involvement in acetyl-CoA transfer and lipid A synthesis and possibly by protein sorting.
The Relationship between Osteoarthritis and Osteoporosis in Patients with Primary Generalized Osteoarthritis

Hastalar ve yontemler: Heberden nodulleri olan el OA’li postmenopozal 80 kadin hasta (ort. yas 58.95±4.63 yil) OA grubu, Heberden nodulleri ve semptomatik OA’si olmayan, 80 hasta (ort. yas 57.62±5.39) kontrol grubu olarak calismaya alindi. Hastalar yas uyumlu idi. Katilimcilarin kan biyokimyasi, tiroid fonksiyon testleri ve kemik dongu belirtecleri (serum kalsiyum, fosfor, alkalen fosfataz, osteokalsin ve idrarda deoksipridinolin) ve 25-hidroksivitamin D3 [25(OH)D3] duzeylerine bakildi. Kemik mineral yogunlugu degerleri, yan torakolomber grafileri, pelvis, diz ve el on-arka radyografileri iki grup arasinda karsilastirmali olarak degerlendirildi. Grafilerin degerlendirilmesi Kellgren-Lawrence skalasina gore yapildi. Her iki grubun lomber ve femur KMY olcumleri cift X isinli absorpsiyometri cihazi ile gr/cm2 olarak olculdu.
Structural view of a fungal toxin acting on a 14‐3‐3 regulatory complex

The fungal phytotoxin fusicoccin stabilizes the interaction between the C‐terminus of the plant plasma membrane H+‐ATPase and 14‐3‐3 proteins, thus leading to permanent activation of the proton pump. This results in an irreversible opening of the stomatal pore, followed by wilting of plants. Here, we report the crystal structure of the ternary complex between a plant 14‐3‐3 protein, fusicoccin and a phosphopeptide derived from the C‐terminus of the H+‐ATPase. Comparison with the corresponding binary 14‐3‐3 complexes indicates no major conformational change induced by fusicoccin. The compound rather fills a cavity in the protein–phosphopeptide interaction surface. Isothermal titration calorimetry indicates that the toxin alone binds only weakly to 14‐3‐3 and that peptide and toxin mutually increase each others' binding affinity ∼90‐fold. These results are important for herbicide development but might have general implications for drug development, since rather than inhibiting protein–protein interactions, which is difficult to accomplish, it might be easier to reverse the strategy and stabilize protein–protein complexes. As the fusicoccin interaction shows, only low‐affinity interactions would be required for this strategy.
Consumer Attitude toward Advertising via Mobile Devices - An Empirical Investigation among Austrian Users

Mobile marketing offers great opportunities for businesses. Marketing activities supported by mobile devices allow companies to directly communicate with their consumers without time or location barriers. However, some areas of mobile marketing still need further investigation. Especially, the topic of advertising via mobile devices is of major interest. It addresses consumers with individualized advertising messages via mobile devices. The underlying paper discusses its relevance and investigates antecedents of consumer attitudes toward advertising via mobile devices. The analysis is based on a consumer survey. For this purpose a quota sample of 815 cellular phone users in Austria has been interviewed. The results indicate that advertising value and advertising message content have the largest impact on attitude toward advertising via mobile devices.
Positive Disposition in the Prediction of Strategic Independence among Millennials

Research on the dispositional traits of Millennials (born in 1980–2000) finds that this generation, compared to earlier generations, tends to be more narcissistic, hold themselves in higher regard and feel more entitled to rewards. The purpose of this intragenerational study is to counter balance extant research by exploring how the positive dispositional traits of proactive personality, core self-evaluation, grit and self-control predict strategic independence in a sample of 311 young adults. Strategic independence is a composite variable measuring a person’s tendency to make plans and achieve long-term goals. A confirmatory factor analysis and hierarchical regression found evidence of discriminant validity across the scales and that three of the four independent variables were statistically significant and positive predictors of strategic independence in the study. The paper discusses research and practical implications, strengths and limitations and areas for future research.
On Optimal Finite-Difference Approximation of PML

A technique derived from two related methods suggested earlier by some of the authors for optimization of finite-difference grids and absorbing boundary conditions is applied to discretization of perfectly matched layer (PML) absorbing boundary conditions for wave equations in Cartesian coordinates. We formulate simple sufficient conditions for optimality and implement them. It is found that the minimal error can be achieved using pure imaginary coordinate stretching. As such, the PML discretization is algebraically equivalent to the rational approximation of the square root on [0,1] conventionally used for approximate absorbing boundary conditions. We present optimal solutions for two cost functions, with exponential (and exponential of the square root) rates of convergence with respect to the number of the discrete PML layers using a second order finite-difference scheme with optimal grids. Results of numerical calculations are presented.
Functional Assays for Analysis of Variants of Uncertain Significance in BRCA2

Missense variants in the BRCA2 gene are routinely detected during clinical screening for pathogenic mutations in patients with a family history of breast and ovarian cancer. These subtle changes frequently remain of unknown clinical significance because of the lack of genetic information that may help establish a direct correlation with cancer predisposition. Therefore, alternative ways of predicting the pathogenicity of these variants are urgently needed. Since BRCA2 is a protein involved in important cellular mechanisms such as DNA repair, replication, and cell cycle control, functional assays have been developed that exploit these cellular activities to explore the impact of the variants on protein function. In this review, we summarize assays developed and currently utilized for studying missense variants in BRCA2. We specifically depict details of each assay, including variants of uncertain significance analyzed, and describe a validation set of (genetically) proven pathogenic and neutral missense variants to serve as a golden standard for the validation of each assay. Guidelines are proposed to enable implementation of laboratory‐based methods to assess the impact of the variant on cancer risk.
Utilization of Legal and Financial Services of Partners in Dementia Care Study

Financial and legal services are unique needs of persons with dementia and their caregivers. This study examines their need for legal and financial assistance and the kinds of legal and financial services provided within Partners in Dementia Care, a telephone-based, care coordination and support service intervention delivered through a partnership between Veterans Affairs (VA) medical centers and local Alzheimer’s Association chapters. Based on comprehensive assessment, and needs prioritization, care coordinators collaboratively planned action steps (specific behavioral tasks) with each caregiver/person with dementia to address the dyad’s identified unmet needs. Results show that 51 (54.8%) of 93 dyads reported a need for legal and financial services. Action steps related to legal and financial need included education or assistance with legal services (27.27%), nonhealth-related financial benefits (32.32%), health-related financial benefits (21.21%), financial management/planning (9.09%), and financial support (10.1%). Comparable numbers of action steps were directed to VA (41.4%) and non-VA (58.6%) services.
Kinetic studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection.

BACKGROUND Isolated thrombocytopenia accompanied by increased amounts of platelet-associated antibody is a common manifestation of human immunodeficiency virus (HIV) infection, and the thrombocytopenia often improves with zidovudine. It is not clear whether the mechanism of HIV-related thrombocytopenia primarily involves autoimmune destruction of platelets or reduced platelet production by megakaryocytes. METHODS We studied the survival of 111In-labeled autologous platelets and performed platelet imaging in 24 men with isolated HIV-related thrombocytopenia (16 who received no treatment and 8 who received zidovudine). We also studied 20 HIV-infected men with normal platelet counts (10 who received no treatment and 10 who received zidovudine) and studied 12 healthy seronegative men as controls. RESULTS Mean (+/- SD) platelet survival was significantly decreased in both the untreated and the zidovudine-treated patients with HIV-related thrombocytopenia (to 92 +/- 33 and 129 +/- 44 hours, respectively; both P < 0.001), as compared with the normal controls (198 +/- 15 hours). Mean platelet survival was also significantly decreased in the HIV-infected patients with normal platelet counts (untreated, 162 +/- 23 hours, P < 0.01; zidovudine-treated, 166 +/- 35 hours, P < 0.05). Imaging studies, however, revealed no evidence of increased clearance of autologous platelets in the liver or spleen in any of these groups. Mean platelet production was significantly depressed in the untreated patients with thrombocytopenia (23,000 +/- 11,000 platelets per cubic millimeter per day, P < 0.001) as compared with the healthy controls (45,000 +/- 6,000 per cubic millimeter per day). Mean platelet production was significantly increased, however, in the men treated with zidovudine, both in those with thrombocytopenia (60,000 +/- 31,000 platelets per cubic millimeter per day, P < 0.01 vs. controls) and in those without thrombocytopenia (68,000 +/- 22,000 per cubic millimeter per day, P < 0.01). CONCLUSIONS Although there was a moderate reduction in platelet survival in HIV-infected persons, these patients, regardless of platelet counts, also had decreased production of platelets, possibly due to viral infection of the megakaryocytes. Zidovudine appears to improve platelet production.
CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning

We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists. Our algorithm, CheXNet, is a 121-layer convolutional neural network trained on ChestX-ray14, currently the largest publicly available chest X-ray dataset, containing over 100,000 frontal-view X-ray images with 14 diseases. Four practicing academic radiologists annotate a test set, on which we compare the performance of CheXNet to that of radiologists. We find that CheXNet exceeds average radiologist performance on the F1 metric. We extend CheXNet to detect all 14 diseases in ChestX-ray14 and achieve state of the art results on all 14 diseases.
Postural Control Strategies Related to Anticipatory Perturbation and Quick Perturbation in Adolescent Idiopathic Scoliosis

Study Design. Cross-sectional study. Objective. To investigate the automatic balance correction related to anticipatory perturbation (AP) and quick backward perturbation in adolescent idiopathic scoliosis (AIS). Summary of Background Data. Most previous studies on AIS patients focused on posture sway and lacked analysis of muscle activated patterns in dynamic standing control. Methods. Thirty-two AIS patients and 23 age- matched normal subjects received perturbation balance tests on an unstable platform. The tilting angle of the platform and the muscle activity of the bilateral lumbar multifidi, gluteus medii, and gastrocnemii muscles were recorded. Electromyographic (EMG) amplitude, onset latencies, and duration were calculated with software accompanied with machine. Results. The AIS group had less posture tilting but higher muscle activities than normal subjects under both perturbation conditions (P < 0.05). Under the AP test, AIS showed earlier onset and prolonged activation of left multifidus and right gastrocnemius compared with normal subjects (P < 0.05). The latency of the multifidus on the lumbar convex side occurred earlier than on the concave side. However, the asymmetric onset timing of the gastrocnemius was the opposite of the multifidi in the AIS group (P < 0.05). In contrast to the AP condition, bilateral leg and trunk muscles activated at similar latencies and durations in the AIS group (P < 0.05). Under the quick backward perturbation test, the control group had longer active duration of right multifidus and bilateral gastrocnemii than AIS to cope with larger platform tilting. In addition, asymmetric onset of gluteus medii and duration of multifidi was observed in the control group (P < 0.05). Conclusion. There were significant differences in posture control patterns between AIS and normal subjects. AIS subjects have asymmetric habitual muscle activities for AP, whereas when coping with sudden balance threats, they react with synchronized recruitment of bilateral postural muscles.
Use of ground observations to simulate the seasonal changes in the backscattering coefficient of the subarctic forest

RADARSAT synthetic aperture radar (SAR) data acquired at C Band, HH polarization, and for the 20/spl deg/-27/spl deg/ and 45/spl deg/-49/spl deg/ incidence angle ranges were available over northern Quebec, Canada, (54/spl deg/N, 72/spl deg/12'W), in the fall of 1996, the winter of 1997, and the spring of 1997. The main land occupation of this area is sparse black spruce (Picea mariana) forests. Vegetation characteristics are jointly used with snow and soil observations coinciding with the satellite overpasses to simulate the seasonal changes in the backscattering coefficient of the subarctic forest. The aim of this study is twofold. First to evaluate the effects of the seasonal changes in vegetation on the RADARSAT SAR data, and second to use backscattering models as a tool for a better interpretation and understanding of the RADARSAT SAR data over snow-covered forested areas. Simulations show the importance of the surface-vegetation interaction term and the wet snow surface roughness on the discrimination between open forest and denser forest, and on the contrast between wet snow and dry snow covers. When comparing the simulations to the RADARSAT SAR data, the poorest results are obtained in the spring for a rough wet snow. It is shown that they are mainly due to a crude evaluation of the vegetation dielectric constant rather than to uncertainties introduced by the spatial variability in the wet snow surface roughness.
Levels of nicotine in dust from homes of smokeless tobacco users.

BACKGROUND Smokeless tobacco products, such as chewing tobacco or moist snuff, contain many of the same constituents as tobacco smoke and are also known to cause cancer; however, little attention has been paid to indirect exposure of children to tobacco constituents via parental smokeless tobacco use. METHODS As part of the California Childhood Leukemia Study, we collected dust samples from 6 residences occupied by smokeless tobacco users, 6 residences occupied by active smokers, and 20 tobacco-free residences. Children's potential for exposure to tobacco constituents was assessed using nicotine concentrations in vacuum dust measured by gas chromatography-mass spectrometry. RESULTS Median nicotine concentrations for residences with smokeless tobacco users were significantly greater than median nicotine concentrations for tobacco-free homes and similar to median nicotine concentrations in homes of active smokers. Using generalized estimating equations derived from a multivariable marginal model to adjust for a history of parental smoking, income, residence construction date, and mother's age and race/ethnicity, we found nicotine levels from homes of smokeless tobacco users to be 21-fold higher than nicotine levels from tobacco-free homes. Based on mass balance equations, we hypothesize that nicotine is transferred to floors in homes of smokeless tobacco users primarily as a constituent of tobacco that is spilled or expectorated. CONCLUSIONS Based on our findings, we conclude that children living with smokeless tobacco users may be exposed to nicotine and other constituents of tobacco via contact with contaminated dust and household surfaces.