Miracle-dz/UniFAR-FTUs huggingface dataset:
Regulation, red tape and location choices of top R&D investors

This paper investigates how product and labour market regulations and red tape affect the way in which top corporate research and development (RD the cost of starting a business and profit tax show lower marginal effects. Moreover, we found that (i) PMR and EPL are complementary (i.e. reducing one would also reduce the negative impact of the other) and (ii) of the three components of the PMR indicator —barriers to trade and investment, state control and barriers to entrepreneurship—the latter is the one with the lowest marginal effect. Policy implications are drawn accordingly.
Online Sellers’ Website Quality Influencing Online Buyers’ Purchase Intention

The increase adoption of Internet among young users in Malaysia provides high prospect for online seller. Young users aged between 18 and 25 years old are important to online sellers because they are actively involved in online purchasing and this group of online buyers is expected to dominate future online market. Therefore, examining online sellers’ website quality and online buyers’ purchase intention is crucial. Based on the Theory of planned behavior (TPB), a conceptual model of online sellers’ website quality and purchase intention of online buyers was developed. E-tailQ instrument was adapted in this study which composed of website design, reliability/fulfillment, security, privacy & trust, and customer service. Using online questionnaire and convenience sampling procedure, primary data were obtained from 240 online buyers aged between 18 to 25 years old. It was discovered that website design, website reliability/fulfillment, website security, privacy & trust, and website customer service positively and significantly influence intention of online buyers to continuously purchase via online channels. This study concludes that online sellers’ website quality is important in predicting online buyers’ purchase intention. Recommendation and implication of this study were discussed focusing on how online sellers should improve their website quality to stay competitive in online business.
Utility of a new left ventricular asynchrony index as a predictor of reverse remodelling after cardiac resynchronization therapy.

AIMS The majority of tissue Doppler indexes proposed to predict left ventricular (LV) reverse remodelling in cardiac resynchronization therapy (CRT) reflects LV asynchrony as assessed in ejection phase. We evaluated the predictive value of a new strain-imaging parameter reflecting the total amount of time spent by 12 LV segments in contracting after aortic valve closure. METHODS AND RESULTS Fifty-nine patients who fulfilled current treatment recommendations were studied before and 6 months after CRT. Time to tissue Doppler systolic peak velocity (Ts) and time exceeding aortic closure (ExcT) in strain curves were measured in 12 LV segments. Ts standard deviation (Ts-SD) and sum of ExcT of overall 12 LV segments (oExcT) were analysed. After 6 months, responders were defined according to > or =15% LV end-systolic volume reduction. Responders (47%) when compared with non-responders (53%) had significantly higher baseline Ts-SD and oExcT values. Receiver operating characteristic (ROC) curve analysis demonstrated that an optimal cutoff value of 760 ms for oExcT yielded 93.5% sensitivity and 82.8% specificity. For Ts-SD at the cutoff of 32 ms, 82% sensitivity and 39% specificity were obtained. Area under ROC was significantly larger for oExcT than for Ts-SD. CONCLUSION o-ExcT is able to predict LV reverse remodelling after CRT.
Growth Hormone Normalises Height, Prediction of Final Height and Hand Length in Children with Prader-Willi Syndrome after 4 Years of Therapy

Background: Based on the reported favourable effects of growth hormone (GH) treatment on growth and body composition in Prader-Labhart-Willi syndrome, we studied age dependency and the long-term effects on growth dynamics to elucidate the assumed hypothalamic GH deficiency. Methods: We examined 23 children treated with hGH (24 U/m2/week) during a median of 4 (range 1.5–5.5) years; group 1: 10 young underweight (age 0.3–4.1 years), group 2: 8 prepubertal overweight (age 3.7–9.5 years) and group 3: 5 pubertal overweight children (age 9.0–14.6 years). Results: After 4 years of therapy, height gain amounted to 1.8 SD; height (0.0 SD) and hand length (–0.2 SD) were normalised in the 2 prepubertal groups; in children above 6 years, height prediction approached parental target height. Weight for height rose in group 1 (to 0.64 SD) and decreased in group 2 (to 0.71 SD) to normal levels. Bone maturation of the pubertal children was too advanced to show a clear growth response to GH (height gain 0.42 SD). Even in this group, weight for height was reduced, but remained supernormal. Conclusion: Under exogenous GH, growth and body proportions are normalised in prepubertal children. With early institution of treatment, final height prediction reaches the parental target height range after 3 years. Such a growth-promoting effect of exogenous GH has so far only been described in children with GH deficiency.
Cutaneous Pseudolymphoma in a Red Tattoo

A 32 year-old healthy woman presented with a 4 month history of pruritus and nodules in a 2-year-old professionally placed tattoo in the lower limb. On examination of the lower right leg she had nodules limited to the red areas of the tattoo, and not in the other colors (Figure 1). Epicutaneous patch testing revealed a positive reaction to nickel, which was considered as non-causative, because the dye did not contain nickel salts.
The Post-revision drift, analyst characteristics and investor attention

The aim of this dissertation is to provide a coherent explanation for the post-analyst recommendation drift. First, I find that the post-analyst recommendation drift is explained by the degree of attention paid by individual investors. Second I find that the extremeness and the credibility of information leads to changes in the degree of attention and a post-analyst recommendation drift. Finally, I find that the diffusion of private information contained in the analyst recommendation interacts with attention related biases leading to a post-recommendation drift.
Speculative Components in M&A Purchase Prices, Acquirers’ Long-Term Performance, and Goodwill Estimation

This study introduces an alternative method for mergers and acquisitions (M&A) accounting and demonstrates its diagnostic properties for predicting acquirers’ performance. While current accounting standards view an M&A as buying assets to add to the acquirer’s balance sheet, the proposed alternative approach views the purchase as buying the business of a target and the value in that business. Accordingly, the purchase price includes the value in the target’s balance sheet plus the added value of the business indicated by the income statement, with the remainder attributed to an alternative goodwill measure. This measure is immediately available to investors on the announcement of the acquisition rather than in subsequent financial reports. The paper shows that this timely alternative goodwill measure is (1) negatively related to the acquirer's long-term returns, (2) positively associated with the future impairments of goodwill reported under current generally accepted accounting principles (GAAP), and (3) incrementally informative over event-date market reactions and acquisition premiums for predicting long-term returns and goodwill impairments.
Localization of the Renal Excretion of the Tritiated Digoxin

Since digoxin is excreted principally in the urine as the unchanged glycoside in patients with or without congestive heart failure, the mechanism of renal excretion is important. The site of renal digoxin excretion was studied in ten dogs by the stop-flow technique after the intravenous injection of tritium (H2) labeled digoxin. Alterations in electrolyte concentration arc known to occur with the stop-flow or slow flow experiments; however, under conditions of these experiments the distal nephron secretion of potassium was only minimally inhibited by digoxin while no changes in sodium concentration were observed. Glomerular filtration of digoxin is established and tubular reabsorption of digoxin is demonstrated by the stop-flow technique in the dog.
Estimating the barcoding gap in a global dataset of cox1 sequences for Odonata: close, but no cigar

Abstract We evaluated the extent of intraspecific and interspecific genetic distances for two highly diverse infraorders of Odonata: Anisoptera and Zygoptera. All cytochrome c oxidase subunit I sequences (cox1), the region chosen for zoological DNA barcoding, present in GenBank for each infraorder were downloaded and curated. For Anisoptera, the final dataset consisted of 2,961 individual cox1 sequences for 536 species and the equivalent numbers for Zygoptera were 2,477 sequences for 497 species. More than 7 million individual genetic comparisons were made and the results indicated that there is a tendency towards a barcoding gap, but that the size of the gap may not be sufficient to robustly infer identities for some taxa. DNA barcoding may be of less use for some odonate taxa, perhaps pertaining to misidentifications in global databases. However, at local scales or with more confined taxonomical sampling, this tool may yet be beneficial in identifying these charismatic organisms.
APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging.

OBJECTIVE To study differences in longitudinal changes in regional cerebral blood flow (rCBF) between apolipoprotein E (APOE) epsilon4 carriers and noncarriers in nondemented older adults from the Baltimore Longitudinal Study of Aging using positron emission tomography in order to determine whether there are regionally specific longitudinal changes in rCBF in APOE epsilon4 carriers that might be related to its well-established role as a genetic risk factor for Alzheimer disease. DESIGN, SETTING, AND PARTICIPANTS Using oxygen 15 ([(15)O])-labeled water positron emission tomography and voxel-based analysis, we compared changes in rCBF over an 8-year period between 29 nondemented APOE epsilon4 carriers and 65 noncarriers older than 55 years. Serial neuropsychological data were collected for all participants. RESULTS Widespread differences were observed in longitudinal change in rCBF between epsilon4 carriers and noncarriers. The predominant pattern was greater rCBF decline in epsilon4 carriers. These differences were observed in the frontal, parietal, and temporal cortices. The affected brain regions were those especially vulnerable to pathological changes in Alzheimer disease. Both epsilon4 carriers and noncarriers remained free of clinical diagnoses of dementia or mild cognitive impairment during the course of the study. CONCLUSIONS Our findings suggest that APOE epsilon4-mediated risk for Alzheimer disease is associated with widespread decline in rCBF over time that precedes the onset of dementia. Accelerated rates of decline in brain function in APOE epsilon4 carriers may contribute to an increased risk for Alzheimer disease and a younger age at onset.
Bacterial Vaginosis in Lesbians and Bisexual Women

Objective: To determine whether bacterial vaginosis (BV) is associated with sexual activity between women. Study Design: Cross-sectional survey of 708 new patients attending 2 sexual health clinics for lesbians and bisexual women in London, U.K. Questionnaire for demographic, sexual history, and sexual practice data linked with the results of genitourinary examination. Results: BV was common (31.4%). The odds of BV was significantly associated with larger numbers of female sexual partners (odds ratio [OR], 1.6; confidence interval [CI], 1.05–2.44 for ≥11 compared with 1–5 partners) and with smoking (OR, 1.43; CI, 1.01–2.03), but not with sex with men or vaginal douching. Conclusions: BV is common in women who have sex with women (WSW). The increasing odds of BV with larger numbers of female sexual partners suggest that BV may be sexually transmitted between women.
Proteins encoded by the long terminal repeat region of mouse mammary tumor virus: identification by hybrid-selected translation

The long terminal repeat (LTR) region of mouse mammary tumor virus (MMTV) is known to contain an open reading frame of sufficient length to code for a protein of 36,000 Mr. The coding capacity of the 3' sequences of MMTV genomic RNA has been demonstrated by in vitro translation studies, which have reported the synthesis of four related proteins: p36, p24, p21, and p18. These proteins are overlapping translation products of the same open reading frame, with the smaller ones initiating at internal methionine codons. From the predicted amino acid sequence of the LTR protein, we have selected a region likely to be antigenic, obtained a synthetic peptide of that region, and raised antiserum to the peptide. The antipeptide serum specifically immunoprecipitated all four proteins from in vitro translated genomic 3' MMTV RNA, plus an additional one of 32,000 Mr. Published sequence data of MMRV LTRs show an internal AUG codon at a position which could initiate a protein of 32,000 Mr. The three smaller in vitro translation products (p24, p21, and p18) were consistently synthesized in much greater amounts than the p36 or p32 protein. The relative amount of each in vitro synthesized protein from genomic MMTV RNA could be predicted and was in good agreement with the postulated effect of flanking nucleotides on the efficiency of the respective AUG initiation codon. Polyadenylated RNAs, isolated from various mouse tissues, were selected by hybridization to plasmid DNA containing MMTV LTR sequences immobilized on nitrocellulose. In vitro translation of hybrid-selected mRNAs isolated from BALB/c mouse lactating mammary glands and carcinogen-induced mammary tumors, followed by immunoprecipitation with antipeptide serum, revealed that only one polypeptide was synthesized by the MMTV LTR-specific mRNA, the 36,000 Mr species.
Depressive Symptoms Moderated the Effect of Chronic Illness Self-Management Training on Self-Efficacy

Background:Identifying moderators of the effects of self-efficacy enhancing interventions could facilitate their refinement and more targeted, cost-effective delivery. Current theories and data concerning the potential moderating effect of depressive symptoms on interventions to enhance patient chronic illness self-management self-efficacy are conflicting. Objectives:To explore the moderating effect of depressive symptoms on the effect of an intervention to enhance patient self-efficacy for self-managing chronic illness. Research Design:Regression analyses using baseline and postintervention (6 weeks) data from an ongoing randomized controlled trial. Subjects:Patients (N = 415) aged ≥40 years recruited from a primary care network in Northern California with arthritis, asthma, chronic obstructive pulmonary disease, congestive heart failure, depression, and/or diabetes mellitus, plus impairment in ≥1 basic activity, and/or a score of ≥4 on the 10-item Center for Epidemiologic Studies Depression Scale (CES-D). Measures:Stanford self-efficacy scale, self-reported depression, CES-D, and Medical Outcomes Study Short Form health status questionnaire (SF-36) Mental Component Summary score. Results:Regression analyses revealed the intervention was effective primarily in those with self-reported depression (interaction effect F = 8.24, P = 0.0003), highest CES-D score category (F = 5.68, P = 0.0037), and lowest (most depressed) Mental Component Summary-36 tercile (F = 4.36, P = 0.0135). Conclusions:Individuals with more depressive symptoms seem more likely to experience self-efficacy gains from chronic illness self-management training than individuals with less depressive symptoms. Future self-management training studies should stratify subjects within study groups by depressive symptom level to further explore its potential moderating effect.
A Quest for a Market: A Profile of the Consumers of a Professional Women’s Basketball Team and the Marketing Implications

Women’s sports is at an all-time high, as evidenced by the emergence of a number of professional women’s sport leagues (such as basketball, baseball, and fast-pitch softball). Notwithstanding the growth and popularity of women’s sports, these leagues will have to compete with other forms of leisure for consumers’ discretionary time and resources. Since financial stability is vital to the longevity of the developing women’s leagues, the competition for consumers will require a greater need for the marketers of women’s professional sport organizations to understand the variety of factors that influence sport consumers’ behavior and shape the composition of their respective markets. Presented in this article are the results of a study in which the consumers of one of the professional women’s basketball teams that competed in the American Basketball League (ABL)were investigated. The teams’ spectators are profiled as sport consumers, factors that influenced their attendance, are identified and implications fo.
Efficacy Of The Cloud Computing Technology In The Management Of Communication And Business Processes Of The Companies

Trends of development and application of different classes of information systems in management according to the types of business processes were investigated in this article. A brief overview of current state of the use of cloud technology in the world and Ukraine was represented. Advantages of using model of "SaaS - Software as a service" was explained on the example of innovation international project "Bitrix 24", where the main objectives of CRM systems were realized combining with wide opportunities of coordination of communicative and business processes of modern companies. The project was translated into the majority European languages and uses tools of the social Intranet environment.
The Level of Green Supply Chain Practices Adoption in Sri Lankan Manufacturing Companies

It is been topical to discuss about Green Supply Chain Management due to increasing environmental issues all over the world. Therefore many scholars have been given their attention to do more research on this area based on their own countries. Through this study researcher expects to strength existing body of knowledge regarding green supply chain management based on the Sri Lankan context. Thus this paper attempts to identify the current level of green supply chain practices adoption in Sri Lankan manufacturing companies and gives comparative analysis of green supply chain practices adoption with Chinese and Japanese manufacturing companies. For this study structured questionnaire was used to collect data from the sample of 125 manufacturing companies in Sri Lanka and data were analyzed using descriptive analysis. In order to have general understanding about the level of green supply chain practices adoption, five stages of adoption level was used as a theoretical base. Findings of this study will be more contributed to strengthen the green supply chain management further for managers, relevant authorities and the government of Sri Lanka. Key words: Environmental Issues, Green Supply Chain Management, Green Supply Chain Practices, Level of Adoption, Manufacturing Companies.
Spanish-speaking patients’ engagement in interactive voice response (IVR) support calls for chronic disease self-management: data from three countries

We measured Spanish-speaking patients’ engagement in Interactive Voice Response (IVR) calls using data from self-management support studies in Honduras, Mexico and the US. A total of 268 patients with diabetes or hypertension participated in 6-12 weeks of weekly IVR follow-up. Participants had an average of 6.1 years of education, and 73% of them were women. After 2443 person-weeks of follow-up, patients had completed 1494 IVR assessments. The call completion rates were higher in the US (75%) than in Honduras (59%) or Mexico (61 %; P < 0.001). Patients participating with an informal caregiver were more likely to complete calls (adjusted odds ratio 1.5; P = 0.03) while patients reporting fair or poor health at enrolment were less likely (adjusted odds ratio 0.59; P = 0.02). Satisfaction rates were high, with 98% of patients reporting that the system was easy to use, and 86% reporting that the calls helped them a great deal in managing their health problems. IVR self-management support is feasible among Spanish-speaking patients with chronic disease, including those living in less-developed countries. Involving informal caregivers may increase patient engagement.
Marital Interaction in Depression: A Comparison of Structural Analysis of Social Behavior and the Kategoriensystem für Partnerschaftliche Interaktion

Background: A number of studies have shown that marital interaction plays an important role regarding etiology, maintenance, and course of depression. The Kategoriensystem für Partnerschaftliche Interaktion (KPI; ‘Coding System for Marital/Family Interaction’) and the Structural Analysis of Social Behavior (SASB) are both widely used to describe and quantify the interactional behavior of patients and their relatives. To evaluate the validity of extrapolating research findings from one system to another, especially in the field of depressive disorders, the two coding systems were compared in an empirical analysis. Sampling and Methods: Videotaped marital problem-solving interaction tasks of 29 married couples with a depressed spouse were coded by means of both systems by separate teams of observers. Results: Between-system comparisons revealed that convergent validity on the level of SASB clusters and KPI verbal categories were moderate and differentiated between the behavior of patients and that of spouses. The KPI nonverbal positive and negative categories were not simply correlated with the SASB affiliation dimension. Conclusion: The results underline the importance of undertaking validation studies with different samples.
Med19(Rox3) Regulates Intermodule Interactions in the Saccharomyces cerevisiae Mediator Complex*

The Saccharomyces cerevisiae Mediator is a 25-subunit complex that facilitates both transcriptional activation and repression. Structural and functional studies have divided Mediator subunits into four distinct modules. The Head, Middle, and Tail modules form the core functional Mediator complex, whereas a fourth, the Cyc-C module, is variably associated with the core. By purifying Mediator from a strain lacking the Med19(Rox3) subunit, we have found that a complex missing only the Med19(Rox3) subunit can be isolated under mild conditions. Additionally, we have established that the entire Middle module is released when the Δmed19(rox3) Mediator is purified under more stringent conditions. In contrast to most models of the modular structure of Mediator, we show that release of the Middle module in the Δmed19(rox3) Mediator leaves a stable complex made up solely of Head and Tail subunits. Both the intact and Head-Tail Δmed19(rox3) Mediator complexes have defects in enhanced basal transcription, enhanced TFIIH phosphorylation of the CTD, as well as binding of RNA Pol II and the CTD. The largely intact Δmed19(rox3) complex facilitates activated transcription at levels similar to the wild type Mediator. In the absence of the Middle module, however, the Δmed19(rox3) Mediator is unable to facilitate activated transcription. Although the Middle module is unnecessary for holding the Head and Tail modules together, it is required for the complex to function as a conduit between activators and the core transcription machinery.