Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Efficacy of Low Dose Recombinant Human Erythropoietin in Combination with Androgen Therapy in Anaemia of Chronic Renal Failure

Objectives: To study the efficacy of low dose recombinant human erythropoietin in combination with androgen therapy in anaemia of chronic renal failure. Material and Methods: Forty five adult male patients with anaemia of chronic renal failure on conservative treatment were enrolled. Patients were randomised into three groups (A, B, and C) of 15 patients each. Group A patients received only recombinant human erythropoietin, group B patients received nandrolone decanoate alongwith recombinant human erythropoietin, and group C patients were given nandrolone decanoate alone for a duration of three months. The dose of recombinant human erythropoietin was 2,000 IU subcutaneously twice a week, and of nandrolone decanoate was 100 mg by deep intramuscular injection once a week. Patients in all the three groups received 100 mg of elemental iron intravenously every fortnight. All the relevant haematological and renal parameters were studied monthly and Ferrokinetic studies were done at the beginning and at the end. Results: There was a statistically significant rise in haemoglobin concentration, packed cell volume, and reticulocyte count in all the three groups. The rise in haematological parameters in group B was more marked followed by group A and group C. The patients above 50 years, who received nandrolone decanoate during the study (group B and C), showed better response of rise in haemoglobin as compared to those below 50 years in the same group. None of the patients had any significant side effects of therapy. Conclusions: Androgens, while not generally acknowledged to be a part of standard regimen in anaemia of chronic renal failure, may need to be considered in patients above 50 years of age and their combination with low dose recombinant human erythropoietin would make the treatment more cost effective.
Measurements of mass-dependent azimuthal anisotropy in central p + Au , d + Au , and 3 He + Au collisions at √ sNN = 200

We present measurements of the transverse-momentum dependence of elliptic flow upsilon(2) for identified pions and (anti)protons at midrapidity (vertical bar eta vertical bar < 0.35), in 0%-5% central p + Au and He-3 + Au collisions at ,root s(NN) = 200 GeV. When taken together with previously published measurements in d + Au collisions at root s(NN) = 200 GeV, the results cover a broad range of small-collision-system multiplicities and intrinsic initial geometries. We observe a clear mass-dependent splitting of upsilon(2) (p(T)) in d + Au and He-3 + Au collisions, just as in large nucleus-nucleus (A + A) collisions, and a smaller splitting in p + Au collisions. Both hydrodynamic and transport model calculations successfully describe the data at low p(T) (<1.5 GeV/c), but fail to describe various features at higher p(T). In all systems, the upsilon(2) values follow an approximate quark-number scaling as a function of the hadron transverse kinetic energy per constituent quark (KET/n(q)), which was also seen previously in A + A collisions.
International Conference “ Food Security , Nutrition and Sustainable Agriculture-Emerging Technologies ” ( February 14-16 , 2019 ) Effect of different concentrations of ethephon on ripening and quality of tomato ( Lycopersicon esculentum ) Sunidhi and

An investigation was conducted at Agriculture Lab, Department of Agriculture, D.A. V College Abohar, and Punjab during the academic year 2018 to study the effect of different concentrations of ethephon on ripening and quality of Tomato. The mature green tomato fruits were dipped in aqueous solution of ethephon at 500, 1000 or 1500 ppm for 5 minutes. The fruits were kept at ambient temperature. The physico-chemical parameters of fruits mature green to senescent stage of maturation were analyzed. The different treatments showed variation in physical and chemical characters. It was observed that maximum change in fruit length and breadth was observed in 500ppm ethephon. The obtained results indicated that there was a gradual increase in TSS values with the advancement in days after treatment. Treatment with ethephon resulted in adequate ripening of fruits after 8 days with uniform red color and acceptable quality. The untreated fruits were hard texture and poor in colour and quality. The ripening with ethephon treatment seems to hold promise in reducing postharvest losses.
CA 125 , YKL-40 , HE-4 and Mesothelin : a new serum biomarker combination in discrimination of benign and malign epithelial ovarian tumor CA 125 , YKL-40 , HE-4 ve Mezotelin : Benign ve Malign Epitelial

Objective: Cancer Antigen 125 (CA125) and Risk of Ovarian Malignancy Algorithm (ROMA) score are used for classification of ovarian masses (benign/malign) in preoperative stage. However, their discrimination capacity are considered insufficient, and greatly effected by histological subtype and menopausal status. This study aimed to investigate diagnostic performance of Human epididymis protein 4 (HE4), Y (tyrosine), K (lysine), and L (leucine)40 (YKL-40), Mesothelin, Rho GDP dissociation inhibitor ß (LyGDI), CA125 or their combinations in discrimination of benign/malign ovarian diseases in preoperative stage. Materials and methods: The study groups were comprised sera of 31 epithelial ovarian cancer (EOC), 30 benign ovarian tumor patients, and 32 healthy women. The diagnostic performance of the biomarkers were evaluated based on ROC-AUC values and logistic regression analysis incorporating menopausal status and clinical diagnosis of the subjects. Results: Our data demonstrates that “CA125-HE4-Mesothelin-YKL-40” had the highest sensitivity at 80%, 90%, 95% specificity 96.8%, 93.6%, 93.6%, respectively. Conclusion: This study provides the first evidence for the combinational uses of “CA125-HE4-Mesothelin-YKL-40” as a panel in distinguishing malign from benign ovarian tumor, not affected by menopausal status unlike ROMA. However, higher patient number may also provide the evaluation of this panel in malign group in terms of tumor stages.
Current earnings , persistence bias , time heterogeneity , and schooling returns : Insights from a dynamic model

A well-established empirical literature suggests that individual current earnings are persistent. Several theoretical arguments support this empirical finding. Yet, the standard IV approach to the estimation of schooling returns uses a static model which does not account for earnings persistence. This paper investigates the consequences of this choice. In particular, it shows that the standard IV approach provides inconsistent estimates of the return to schooling i) at labour-market entry due to “persistence bias” and ii) during the working life because “time heterogeneity” is not accounted for. JEL Classification: C23; I21; J31
Clinical Trial Update The Cancer Genome Atlas Project on Muscle-invasive Bladder Cancer

The Cancer Genome Atlas (TCGA) project in bladder cancer reported the integrated genomic analysis of the first 131 patients in 2014 [1]. We analyzed chemotherapy-naive, muscle-invasive urothelial cancers for somatic mutation, DNA copy number variants, mRNA and microRNA expression, protein and phosphorylated protein expression (RPPA), DNA methylation, integrated with comprehensive clinical and pathologic data. This muscle-invasive cohort has one of the highest somatic mutation rates, with mean and median somatic mutation rates of 7.7 and 5.5 per megabase, respectively, similar to adenocarcinoma and squamous cell carcinoma of the lung and melanoma. We reported 32 significantly mutated genes (SMGs) involved in multiple pathways including cell cycle regulation (93% of tumors), chromatin remodeling (76%), DNA damage response, transcription factors, and RAS/RTK/PI3K (72%) signaling pathways. Four SMGs—ARID1a, MLL2, KDM6a, and EP300—are involved in epigenetic regulation and were mutated in up to one-quarter of the tumors. One-third of the tumors were characterized by cancer-specific DNA hypermethylation. An additional 281 tumors are in the pipeline, and the complete data set will be analyzed beginning in early 2015. We have preliminary mutation data on 238 samples (including the first 131), and six additional SMGs have been identified. Several of the 38 SMGs have not been described previously in bladder cancer. Combining copy number variation and somatic mutations, 69% of tumors harbor one potentially actionable target or more. Three mutation cluster (I) ‘‘Focally amplified’’
APICAL SEALING EFFICIENCY OF DIFFERENT OBTURATION TECHNIQUES OVER APICALLY BROKEN ROTARY NICKEL-TITANIUM FILES (AN IN VITRO STUDY)

Introduction: A broken instrument within the root canal is a panic problem which one should never wish to occur during routine endodontic therapy. However, the decision regarding how to manage this problem is complex. Therefore, the clinician must evaluate carefully the options of treatment; retrieving the instrument; bypassing the instrument; or leaving the fractured instrument in the canal as part of the final root canal filling. Objective: The objective of this study is to compare the sealing ability of three obturation techniques over apically broken nickel-titanium (Ni-Ti) ProTaper file. Materials and methods: Forty eight extracted human single-rooted mandibular premolars were prepared using ProTaper files (PT) and subjected to breakage of 3mm from F5 tip at the apical one third of the canal. The canals were randomly divided into three groups of 12 teeth each according to type of obturation technique; E&Q plus obturation, using a Thermafil obturator, or lateral compaction technique. The remaining 12 teeth served as positive controls which contained canals with apically broken files only without any type of obturation. Apical leakage was assessed by the dye penetration method in which all teeth were immersed in 2% methylene blue dye for 48 hours. Then the specimens were longitudinally split into two halves. Linear dye penetration was measured in millimeters under a stereomicroscope for each specimen. Statistical analysis of the results was performed using Kruskal-Wallis and post hoc tests. Results: The results showed no statistically significant difference in apical leakage between the three obturation techniques used over apically broken F5 files. Conclusions: All obturation techniques used over apically broken PT files played a significant role in the sealing ability
3-7-2018 Assessing the Association of Food Preferences and Self-Reported Psychological Well-Being among Middle-Aged and Older Adults in Contemporary China-Results from the China Health and Nutrition Survey

China has undergone rapid social transitions within the last few decades. However, mental health issues, challenges to psychological well-being, and poor dietary choices have gradually surfaced. These health concerns are related to the rapid growth of the aging population and of the fast-paced industrialized society. Nevertheless, there is little knowledge about food preferences and psychological well-being measurements in contemporary China. Applying the 2011 China Health and Nutrition Survey (CHNS) with a cross-sectional study design (n = 7970), we conducted multinomial logistic regression models to investigate the associations of food preferences, including fast food, salty snacks, fruits, vegetables, and sweetened beverages, with psychological well-being among Chinese middle-aged and older adults (age ≥ 45). Food preferences are mostly associated with psychological well-being (p < 0.05). However, respondents’ preferences regarding fast food, salty snacks, and sweetened beverages are associated not only with poorer psychological health status, but also with positive psychological well-being. We speculate that Chinese older adults may consume Westernized fast food and salty snacks as pleasure to the palate due to the recent Westernization in modern China. We also provide practical implications of results from this preliminary study.
Learning from Feedback : Evidence from New Ventures 5 / 18 / 2017

Despite the importance of learning to theories of firm entry and exit, there is evidence that entrepreneurs are overconfident, failing to update their beliefs in response to new information. I assess the effect of negative feedback on early stage startups using application and judging data from 96 new venture competitions, some of which privately inform ventures of their relative rank. I use a difference-in-differences design as well as two matching estimators to compare lower and higher ranked losers, across competitions in which they did and did not observe their standing. Receiving negative feedback increases venture abandonment by about 26 percent. Feedback also seems to increase the efficiency of serial entrepreneurship. Responsiveness varies by venture technology type, stage and risk, as well as founder education and other dimensions. This heterogeneity has implications for theories of innovation and firm dynamics. s s ⇤NYU Stern. Email: sabrina.howell@nyu.edu. Click Here for Latest Version and Appendix. For especially useful comments, I thank Manuel Adelino, Augustin Landier, Josh Lerner, David Robinson, Annette Vissing-Jørgensen, and seminar participants at the NBER Entrepreneurship Working Group. I am also grateful to the Kauffman Foundation, which funded this project. Finally, I thank Adam Rentschler of Valid Evaluation, and all the others who provided the data, including Lea Lueck, Allison Ernst, and Catherine Cronin. Lucy Gong, Sreyoshi Mukherjee, and Jack Reiss provided excellent research assistance. “The distance is so great between our present psychological knowledge of the learning and choice processes and the kinds of knowledge needed for economic and administrative theory that a marking stone placed halfway between might help travellers from both directions to keep to their courses. ” -Herbert Simon, The Quarterly Journal of Economics, 1955
UNIQUENESS AND LONG TIME ASYMPTOTIC FOR THE KELLER-SEGEL EQUATION - PART I. THE PARABOLIC-ELLIPTIC CASE

The present paper deals with the parabolic-elliptic Keller-Segel equation in the plane in the general framework of weak (or “free energy”) solutions associated to initial datum with finite mass M , finite second moment and finite entropy. The aim of the paper is threefold: (1) We prove the uniqueness of the “free energy” solution on the maximal interval of existence [0, T ∗) with T ∗ = ∞ in the case when M ≤ 8π and T ∗ < ∞ in the case when M > 8π. The proof uses a DiPerna-Lions renormalizing argument which makes possible to get the “optimal regularity” as well as an estimate of the difference of two possible solutions in the critical L4/3 Lebesgue norm similarly as for the 2d vorticity Navier-Stokes equation. (2) We prove immediate smoothing effect and, in the case M < 8π, we prove Sobolev norm bound uniformly in time for the rescaled solution (corresponding to the self-similar variables). (3) In the case M < 8π, we also prove weighted L4/3 linearized stability of the self-similar profile and then universal optimal rate of convergence of the solution to the self-similar profile. The proof is mainly based on an argument of enlargement of the functional space for semigroup spectral gap. Preliminary version of October 29, 2013
Vasopressin secretion by hypertonic saline infusion during hemodialysis : effect of cardiopulmonary recirculation

Background. Intradialytic hypotension is the most common and severe acute complication of hemodialysis therapy. In our previous study, infusion of 20 mL of 10% saline into the venous line of a dialyzer increased blood pressure during dialysis hypotension by stimulating arginine vasopressin (AVP) secretion, independent of its effect on plasma volume (PV). This study examines the mechanism by which a small amount of hypertonic solution stimulates AVP secretion. Methods. Hemodialysis patients were infused with 20 mL of 2.5 M saline (100 mOsm) over 5 (Protocol 1) or 2 min (Protocol 2) or with isotonic saline (Protocol 3) into the venous line. Results. Arterial plasma osmolality (Posm) increased by 28.1 and 16.0 (P < 0.0001), while peripheral venous Posm increased by only 8.6 and 8.9 mOsm/kg H2O (P < 0.001) in Protocols 2 and 1, respectively. Plasma AVP (PAVP) increased significantly by 18.6 and 5.6 pg/mL, PV by 7.2 and 5.5% and mean arterial pressure (MAP) by 15.0 and 7.2 mmHg in Protocols 2 and 1, respectively. Thus, there were large differences in Posm between arterial and peripheral venous blood; osmolar gap, PAVP and MAP increased in proportion to the infusion rate. Isotonic saline (30.8 mOsm) infusion increased PV by 8.7% and MAP by 7.2 mmHg. Conclusions. Our results indicate that by a mechanism similar to cardiopulmonary recirculation, hypertonic saline infusion caused a striking increase in arterial Posm that enhanced AVP secretion and raised blood pressure. The effect of hypertonic saline on PV was less than one-third of isotonic saline under similar osmolar loads.
The Effect of PRF and PRP for New Bone Formation of beta-TCP in Skull of White Rabbit

Purpose: Addition of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) to grafting material has become widely accepted additively for bone regeneration because it can raise high expectations on it's clinical potential. The aim of this study was to evaluate the efficacy of PRP and PRF on early bone regeneration of rabbits when used in combination with beta tricalcium phosphate. Methods: In eight rabbits, the calvarium was exposed and the two marrows were penetrated. After then these artificial bone defects were augmented with -TCP or -TCP with PRP or -TCP with PRF and covered. The animals were sacrificed after four and eight weeks. Histologic findings were observed under the light-microscope and histomorphometric analysis was performed by measuring calcified area of new bone formation within the CSD. Results: They demonstrated that new bone formation tended to be produced along the outline of graft materials. More amounts of newly bone was regenerated in -TCP only and in combination of-TCP with PRF and it was statistically significant. In contrast, there was no significant difference between nothing apply and -TCP with PRP groups in the relative amounts of newly mineralized bone. Conclusion: Within the limitation of this study, it can be concluded that PRF in combination with -TCP showed a positive effect on bone regeneration and statistically it was significant.
srcDiff: A syntactic differencing approach to improve the understandability of deltas

An efficient and scalable rule‐based syntactic differencing approach is presented. The tool srcDiff is built upon the srcML infrastructure. srcML adds abstract syntactic information into the code via an XML format. A syntactic difference of srcML documents is then taken. During this process, the differences are further refined using a set of rules that model typical editing patterns of source code by developers. Thus, the resulting deltas model edits that are programmer centric versus a purely syntactic tree edit view. Other syntactic differencing approaches focus on obtaining an optimal tree edit distance with the assumption that this will produce an accurate difference. While this may work well for small or simple changes, the differences quickly become unreadable for more complex changes. By contrast, the approach presented here purposely deviates from an optimal tree edit difference in order to create a delta that is both easier to understand and better models changes between the original and modified. To evaluate the approach, a comparison user study against a state‐of‐the‐art syntactic differencing approach and two line‐based differencing tools is conducted as an online within‐participant study with about 70 subjects on 14 sample changes. The results provide support that the rule‐based syntactic differencing produces more accurate and understandable deltas.
Master of Science Thesis

TAMPERE UNIVERSITY OF TECHNOLOGY Master’s Degree Programme in Science and Engineering NASKALI, LIISA: Integration and synchronization of devices in a nonlinear microscopy setup Master of Science Thesis, 65 pages, 3 Appendix pages March 2015 Major: Advanced Engineering Physics Examiners: Prof. Martti Kauranen and Dr. Godofredo Bautista
Influence of long-term intervention with dietary counseling , long-chain n – 3 fatty acid supplements , or both on circulating markers of endothelial activation in men with long-standing hyperlipidemia 1 – 3

Background: Dietary factors and very-long-chain n 3 polyunsaturated fatty acids (n 3 PUFAs) may influence the atherothrombotic process. Elevated concentrations of circulating cell adhesion molecules, thrombomodulin (TM), von Willebrand factor (vWF), and tissue-type plasminogen activator antigen (tPAag) are related to atherothrombotic cardiovascular disease. Objective: The randomized Diet and Omega-3 Intervention Trial (DOIT) targeted a comparison of the effect of 3-y dietary counseling, n 3 PUFA supplementation (2.4 g/d), or both on circulating markers of endothelial activation. Design: The study included 563 elderly men with long-standing hyperlipidemia. The men were randomly assigned by factorial design into 4 groups: control (no dietary counseling and placebo capsules), dietary counseling (and placebo capsules), n 3 PUFA supplementation (no dietary counseling), and dietary counseling and n 3 PUFA supplementation. Results: Serum concentrations of fatty acids reflected good compliance. Dietary counseling was followed by significantly reduced concentrations of soluble intercellular adhesion molecule 1 (sICAM-1; P 0.001), sTM (P 0.004), and tPAag (P 0.001) than in subjects without dietary counseling. After n 3 PUFA supplementation, significantly reduced concentrations of sICAM-1 (P 0.001) and sTM (P 0.006) were observed when compared with subjects receiving placebo capsules. An increase in tPAag was not significantly different from that observed in subjects receiving placebo capsules. For sICAM-1, a significant effect was observed for both interventions combined. Conclusions: Each intervention (dietary counseling or n 3 PUFA supplements) reduced sTM and sICAM-1 concentrations, indicating decreased endothelial activation. The tPAag increase in the groups not receiving dietary counseling (pooled), which indicates progression of atherosclerosis, was significantly counteracted by dietary counseling. Am J Clin Nutr 2005;81:583–9.
The XRCC 1 Arg 280 His Gene Polymorphism and Hepatocellular Carcinoma Risk : A Meta-analysis

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality in the world (Parkin et al., 2000). HCC is a significant health problem, the malignancy occurring more often among men than women, with the highest incidence rates reported in East Asia (Kiran et al., 2009). Both biological and biochemical evidence demonstrated that the major risk factors for HCC were alcoholism, hepatitis B and C, liver cirrhosis, hemochromatosis, aflatoxin and type 2 diabetics (Niwa et al., 2005). In addition, epidemiological studies provide strong evidence that genetic factors are important in the pathogenesis of HCC (Chen et al., 2012). The X-ray repair cross-complementing group 1 (XRCC1) protein plays a central role in DNA repair pathways.And XRCC1 gene is located on chromosome 19q13.2, spans a genetic distance of 32 kb, comprises of 17 exons, and encodes a 70-kDa protein consisting of 633 amino acids (Lindahl et al., 1999). Three common single nucleotide polymorphisms lead to amino acid substitutions in XRCC1 at codons 194 (exon 6, Arg-Trp), 280 (exon 9, Arg-His), and 399 (exon 10, Arg-Gln) . These variations could alter XRCC1 function, diminish repair kinetics, and result in altered efficiency of the protein, eventually induce the cancer development. Previous a systematic review suggested that XRCC1 Arg280His polymorphism may be biomarker of cancer