Miracle-dz/UniFAR-FTUs huggingface dataset:
Reversing autism: Longitudinal data from an ongoing autism intervention study

Building on previously reported results, this study presents longitudinal data involving the implementation of a single, safe, over-the-counter food supplement previously identified and shown in a rigorous clinical trial to significantly improve outcomes among participants with autism spectrum disorder. Six month outcomes for the supplement use demonstrated a 42% reduction in a battery of attributes expressed at the severe or moderately serious level (to no problem or a slight problem level). Current (but sparse) data demonstrate a 59% reversal at the 12-month period. A second parallel combination strategy that combined the supplement with the use of a vibrational medicine device yielded even more remarkable improvements with a 74% reversal in six months and an 89% reversal after 12 months. Without any side effects, and with either a very inexpensive and safe one-a-day capsule supplement or a quite low-cost device in combination, either strategy continues to demonstrate a powerful and positive intervention for individuals with autism spectrum disorder. These include males and females, ages three to 33, some with significant autism behaviors for more than 25 years. The Therapeutics Research Institute continues to add participants and will continue to accrue data for the foreseeable future as long as the (positive) outcomes warrant. Correspondence to: Steven Evans, Therapeutics Research Institute, Omaha, Nebraska 68131, USA, E-mail: sevans@gsm-usa.com Received: May 23, 2017; Accepted: June 05, 2017; Published: June 09, 2017 Background This report will summarize longitudinal data regarding an ongoing intervention study for individuals with autism spectrum behavior. It is a follow-up to a prior report [1] which described the beginning of this Study using a combination strategy which we will shortly but briefly review below. That Study by Evans and Fuller in turn was initiated and prompted by yet a prior clinical trial [2] providing a simple, safe, over-the-counter food supplement, which yielded significant positive outcomes after a 18-week period. As previously reported by Evans and Fuller, their combination intervention yielded an approximately 39% reduction in presenting attributes of the autism cohort which compared favorably to the approximately 34% reduction obtained by the trial noted. It may be noted that these two figures are not really comparable since different assessment methods were employed in each case.
Genotyping of Pasteurella multocida ovine and bovine isolates from Iran based on PCR-RFLP of ompH gene

Pasteurella multocida ( P. multocida ), A Gram-negative facultative anaerobic bacterium, is a causative animal pathogen in porcine atrophic rhinitis and avian fowl cholera. The outer membrane of Gram-negative bacteria contains of many different protein in very high copy numbers. One of the major outer membrane, the H proteins have functional as high immunogenicity and antigenicity. In this study to increase information about epidemiology of ovine and bovine P. multocida , the 24 isolates from sheep and nine isolates from cattle were investigated by PCR-RFLP analysis of the ompH gene. In all 33 isolates, digestion of the amplified fragment of ompH gene by using EcoR I, cfo I and Hind III produced 3, 5 and 3 different restriction patterns respectively. Sixteen RFLP patterns were found among 33 investigated P.multocida isolates. This study showed that, the PCR RFLP based on ompH gene is potentially a useful method for typing of P. multocida isolates from sheep and cattle . The RFLP patterns of this gene exhibited extensive restriction site heterogeneity, which may be particularly suitable for fingerprinting of P. multocida isolates. Considering ompH protein as a protective immunogenic moiety of P. multocida , the results of this study showed a heterogenic bacteria and this means the possibility to produce a multivalent vaccine to be protective against diseases caused by this organism in sheep and cattle in Iran.
The generalized Effros-Hahn conjecture for groupoids

The generalized Effros-Hahn conjecture for groupoid C * -algebras says that, if G is amenable, then every primitive ideal of the groupoid C*-algebra C * (G) is induced from a stability group. We prove that the conjecture is valid for all second countable amenable locally compact Hausdorff groupoids. Our results are a sharpening of previous work of Jean Renault and depend significantly on his results.
Influence of oestradiol and tamoxifen on oestrogen receptors-α and -β protein degradation and non-genomic signalling pathways in uterine and breast carcinoma cells

Tamoxifen acts as an oestrogen antagonist in the breast reducing cell proliferation, but in the uterus as an oestrogen agonist resulting in increased cell proliferation. Tamoxifen exerts its tissue-specific effects through the oestrogen receptors (ERalpha or ERbeta). The levels and functions of the two ERs affect the response of the target tissue to oestrogen and tamoxifen. We examined the control of ER stability in breast and uterine cell lines using western blotting and RT-PCR. In MCF-7 breast-derived cells, ERalpha and ERbeta proteins were rapidly degraded via the proteasome pathway in response to oestradiol; conversely tamoxifen stabilised both receptors. In Ishikawa uterine-derived cells, oestradiol and tamoxifen stabilised ERalpha but led to degradation of ERbeta by the proteasome pathway. Further investigations showed that oestradiol induced activation of the non-genomic ERalpha/Akt signalling pathway in MCF-7 cells. We have demonstrated that the alternative Erk signalling pathway is activated in Ishikawa cells following oestradiol treatment in the absence of an active proteasome pathway and therefore increased levels of ERbeta. In conclusion, our data have demonstrated tamoxifen or oestradiol control of ER subtype stability and that non-genomic activation of transcription pathways is cell specific.
The Relationship between Voluntary Disclosure and Stock Liquidity of Listed Companies on the Tehran Stock Exchange

In the present study, the relationship between the amplitude of voluntary disclosure as an external control mechanism, and stock liquidity analyzed in the listed companies on the Tehran Stock Exchange during 2009-2013.Using eliminatory systematic sampling, 80 companies were studied as the research sample. Voluntary disclosure was determined by 71 indicators have also been used in previous studies (Kashanipoor et al., 2009) based on the indicators proposed by Botosan (1997). In order to measure stock liquidity as research by Setayesh et al. (2011), measures of monetary volume of daily stock trading in IRR, average daily turnover of shares, and number of daily transactions of stocks. Research hypotheses have been analyzed using econometric techniques and multiple linear regressions.The results indicate that there is no significant relationship between amplitude of voluntary disclosure and stock liquidity. However, there is a positive and significant relationship between liquidity criteria and firm size and profitability opportunities. In other words, in such companies, stock liquidity is higher than other companies. Research findings are consistent with Hariss (1994) and Branch and Freed (1997), and are inconsistent with the results of Matolscy et al., (2007) and Espinosa et al., (2007) that confirmed the existence of a direct relationship between disclosure and liquidity. DOI: 10.5901/mjss.2015. v6n2p84
Low seroprevalence of Chlamydia abortus in dairy cows of hot environment in southern of Mexico

Chlamydia abortus (C. abortus) are Gram-negative obligate, intracellular bacteria responsible of major economic losses due to infection and subsequent induction of abortion in several animal species, including humans. To test the prevalence of C. abortus in dairy cows in Mexico, 271 sera were tested for the presence of antiC. abortus antibodies. Detection of antiC. abortus antibodies was carried out with a commercial indirect ELISA kit. Optical density readings specific to C. abortus were low (14.53 ± 9.55) ranging from 2.81% 90.21%. Only two sera from State of Mexico exhibited positive readings, showing a prevalence of 0.73%. It is concluded that the seroprevalence of C. abortus in dairy cattle in Mexico is low. [Ana Rosa PRAGA-AYALA, Roberto MONTES DE OCA-JIMÉNEZ. César ORTEGA-SANTANA, A.Z. M. SALEM, Víctor CUBILLOS-GODOY, Pomposo FERNÁNDEZ-ROSAS, Humberto G. MONROY-SALAZAR. Low seroprevalence of Chlamydia abortus in dairy cows of hot environment in southern of Mexico. Life Sci J 2014;11(11):790-793]. (ISSN:1097-8135). http://www.lifesciencesite. com. 142
Biren A. Nagda, Sandra R. Gregerman, John Jonides, William von Hippel, and Jennifer S. Lerner - Undergraduate Student-Faculty Research Partnerships Affect Student Retention - The Review of Higher Education 22:1

In 1993, 2.4 million students entered college; of those, some 1.1 million will leave without a degree (Tinto, 1993). This is not a new trend. Data from the American College Testing Program show that the first-year attrition rate for all students in four-year public universities has remained largely unchanged over the last decade. In 1983, this rate was 29.1%; in 1992 it was 28.3% (Tinto, 1993). The other end of the undergraduate time-scale looks equally distressing. In 1983, the graduation rate at the same institutions was 52.6% while in 1992 it had declined to 46.7%. The phenomenon of college attrition is even more exaggerated among certain underrepresented minority groups. Hispanics graduated at a rate of only 35%, and African [End Page 55] Americans at a rate of only 45% (Brower, 1992), far below the rates for White students (Tinto, 1993).
Observabilty Properties and Deterministic Algorithms in Visual-Inertial Structure from Motion

This paper discusses the visual-inertial structure from motion problem (VI-SfM problem) with special focus on the following three fundamental issues: observability properties, resolvability in closed form and data association. Regarding the first issue, after a discussion about the current state of the art, the paper first investigates more complex scenarios. Specifically, with respect to the common formulation, which assumes three orthogonal accelerometers and three orthogonal gyroscopes, the analysis is extended to cope with the cases of a reduced number of inertial sensors and any number of point features observed by monocular vision. In particular, the minimal case of a single accelerometer, no gyroscope and a single point feature is addressed. Additionally, the analysis accounts for biased measurements and unknown extrinsic camera calibration. The results derived for these new and very challenging scenarios have interesting consequences both from a technological and neuroscientific perspective. Regarding the second issue, a simple closed form solution to the VI-SfM is presented. This solution expresses the structure of the scene and the motion only in terms of the visual and inertial measurements collected during a short time interval. This allows introducing deterministic algorithms able to simultaneously determine the structure of the scene together with the motion without the need for any initialization or prior knowledge. Additionally, the closed-form solution allows us to identify the conditions under which the VI-SfM has a finite number of solutions. Specifically, it is shown that the problem can have a unique solution, two distinct solutions or infinite solutions depending on the trajectory, on the number of point-features and on their arrangement in the 3D space and on the number of camera images. Finally, the paper discusses the third issue, i.e., the data association problem. Starting from basic results in computer vision, it is shown that, by exploiting the information provided by the inertial measurements, a single point correspondence (in the case of a planar motion) and two point correspondences (for a general 3D motion) are sufficient to characterize the motion between two camera poses. This allows us to use a 1-point RANSAC algorithm (in the planar case) or a 2-point RANSAC algorithm (in the general 3D case) to detect outliers. The paper concludes with some discussion about connections to related research fields both in the framework of computer science and neuroscience.
Analysis of the Extended Technology Acceptance Model in Online Travel Products

Bu calismada tuketicilerin online seyahat urunleri kabulunun anlasilmasinda, teknoloji kabul modeli (TAM) algilanan eglence ve algilanan guvenlik boyutlari ile genisletilmistir. Calismanin verileri e-mail yoluyla anket teknigi ile toplanmistir. Verilerin normal dagilmamasi ve orneklem boyutunun kucuk olmasi nedeniyle verilerin analizi icin kismi en kucuk kareler teknigi kullanilmistir. Yapisal esitlik modeli ile, algilanan kullanim kolayligi, algilanan eglence ve algilanan guvenin tuketicilerin online alisverise yonelik tutumlarini etkiledigi ortaya cikarilmistir. Algilanan eglence, algilanan kullanislilik uzerinde guclu bir etkiye sahiptir. Ayrica, algilanan kullanislilik, online alisverise karsi tutuma gore davranissal niyet uzerinde daha guclu bir etkiye sahiptir
Implicit and Spontaneous Theory of Mind Reasoning in Autism Spectrum Disorders

might falsely assume an object could be in a certain location, the probability of fixating this location rose when the person started to report his or her assumption about the object’s location. This procedure can reveal sensitivity to other’s mental states with a crucial advantage: it serves as online measure of ToM reasoning in a natural social interaction without overtly asking for other’s mental states (cf., Tanenhaus & Spivey-Knowlton, 1996). Pupillary dilation. It may also be worthwhile to consider pupillary dilation. Changes in the diameter of the pupil can be linked to attentional shifts and changes in mental states (Laeng, Sirois & Gredebäck, 2012). This might not only be useful to detect if subjects react to another’s mental state, but also to see which information at what point in time has led to such a response.
Mechanical deformation of monocytic THP-1 cells : occurrence of two seqential phases with differential sensitivity to metabolic inhibitors

Blood leukocytes can exhibit extensive morphological changes during their passage through small capillary vessels. The human monocytic THP-1 cell line was used to explore the metabolic dependence of these shape changes. Cells were aspirated into micropipettes for determination of the rate of protrusion formation. They were then released and the kinetics of morphological recovery was studied. Results were consistent with Evans' model (Blood, 64 : 1028, 1984) of a viscous liquid droplet surrounded by a tensile membrane. The estimated values of cytoplasmic viscosity and membrane tension were 162 Pa.s and 0.0142 millinewton/m respectively. The influence of metabolic inhibitors on cell mechanical behaviour was then studied : results strongly suggested that deformation involved two sequential phases. The cell elongation rate measured during the first 30 seconds following the onset of aspiration was unaffected by azide, an inhibitor of energy production, and it was about doubled by cytochalasin D, a microfilament inhibitor, and colchicine, a microtubule inhibitor. However, during the following two minutes, deformation was almost abolished in cells treated with azide and cytochalasin D, whereas the protrusion of control cells exhibited about threefold length increase. It is concluded that, although cells seemed to deform as passive objects, active metabolic processes were required to allow extensive morphological changes triggered by external forces.
Sinulariadiolide, a Novel Marine Norditerpenoid from Okinawan Soft Coral of the Genus, Sinularia

A new marine norditerpenoid, sinulariadiolide, was isolated from Okinawan soft coral of the genus, Sinularia. Its structure was determined by spectroscopic analysis and chemical reaction. This compound is structurally characterized by a new carbon skeleton and two lactonic moieties, five-membered and nine-membered, the latter being conjugated to a 2-hydroxylated carbon−carbon double bond. A possible biogenesis of sinulariadiolide is briefly discussed.
Bond lengths and quadratic force field for cubane

The molecular structure of pentacyclo [4.2. 0.0 2,5 . 0 3,8 . 0 4,7 ] octane (cubane) has been determined in the gas phase at a temperature of 77°C. Parameter values were obtained from four types of refinements: those based on electron-diffraction (ED) data alone, ED data with inclusion of a microwave (MW) rotational constant for cubane-d 0 available from the literature, ED data with allowance for single-double multiple scattering (MS) effects, and the ED-MW data with allowance for MS effects. A complete quadratic vibrational force field was also evaluated
Dominant patterns of summer ozone pollution in eastern China and associated atmospheric circulations

Abstract. Surface ozone has been severe during summers in the eastern parts of China, damaging human health and flora and fauna. During 2015–2018, ground-level ozone pollution increased and intensified from south to north. In North China and the Huanghuai region, the O3 concentrations were highest. Two dominant patterns of summer ozone pollution were determined, i.e., a south–north covariant pattern and a south–north differential pattern. The anomalous atmospheric circulations composited for the first pattern manifested as a zonally enhanced East Asian deep trough and as a western Pacific subtropical high, whose western ridge point shifted northward. The local hot, dry air and intense solar radiation enhanced the photochemical reactions to elevate the O3 pollution levels in North China and the Huanghuai region; however, the removal of pollutants was decreased. For the second pattern, the broad positive geopotential height anomalies at high latitudes significantly weakened cold air advection from the north, and those extending to North China resulted in locally high temperatures near the surface. In a different manner, the western Pacific subtropical high transported sufficient water vapor to the Yangtze River Delta and resulted in a locally adverse environment for the formation of surface ozone. In addition, the most dominant pattern in 2017 and 2018 was different from that in previous years, which is investigated as a new feature.
Near field diffraction of cylindrical convex gratings

We analyze the field produced by a cylindrical convex diffraction grating at the Fresnel regime for several kinds of light sources, including a monochromatic quasipunctual source, finite size, and polychromatic sources. These results can help one understand the functioning of rotary optical encoder technology. A decrease in the self-image contrast is produced for finite nonpunctual sources. In addition, the polychromaticity of the source affects the smoothness of the self-images, making them quasicontinuous from a certain distance from the grating forward. Finally, we experimentally validate the obtained analytical predictions.
Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

To transport or not to transport Therapeutic drug delivery into cells is complicated by membrane proteins like ABCB1 (also termed P-glycoprotein) that shuttle diverse compounds out of cells. Alam et al. determined high-resolution cryo–electron microscopy structures of ABCB1 bound either to a substrate, the cancer drug Taxol, or to the ABCB1 inhibitor zosuquidar. The conformational changes that facilitate drug transport are caused by hydrolysis of adenosine triphosphate (ATP). The structures show that, although Taxol and zosquidar bind to the same site, subtle structural differences lead to altered conformations of the nucleotide binding domains that are responsible for ATP hydrolysis. Science, this issue p. 753 Cryo–electron microscopy reveals molecular details of a multidrug transporter’s interactions with drugs and lipids. ABCB1, also known as P-glycoprotein, actively extrudes xenobiotic compounds across the plasma membrane of diverse cells, which contributes to cellular drug resistance and interferes with therapeutic drug delivery. We determined the 3.5-angstrom cryo–electron microscopy structure of substrate-bound human ABCB1 reconstituted in lipidic nanodiscs, revealing a single molecule of the chemotherapeutic compound paclitaxel (Taxol) bound in a central, occluded pocket. A second structure of inhibited, human-mouse chimeric ABCB1 revealed two molecules of zosuquidar occupying the same drug-binding pocket. Minor structural differences between substrate- and inhibitor-bound ABCB1 sites are amplified toward the nucleotide-binding domains (NBDs), revealing how the plasticity of the drug-binding site controls the dynamics of the adenosine triphosphate–hydrolyzing NBDs. Ordered cholesterol and phospholipid molecules suggest how the membrane modulates the conformational changes associated with drug binding and transport.
On the choice of grasp type and location when handing over an object

During a handover, passers prefer precision grasps and grasp purposive parts of objects, leaving “handles” free for receivers. The human hand is capable of performing countless grasps and gestures that are the basis for social activities. However, which grasps contribute the most to the manipulation skills needed during collaborative tasks, and thus which grasps should be included in a robot companion, is still an open issue. Here, we investigated grasp choice and hand placement on objects during a handover when subsequent tasks are performed by the receiver and when in-hand and bimanual manipulation are not allowed. Our findings suggest that, in this scenario, human passers favor precision grasps during such handovers. Passers also tend to grasp the purposive part of objects and leave “handles” unobstructed to the receivers. Intuitively, this choice allows receivers to comfortably perform subsequent tasks with the objects. In practice, many factors contribute to a choice of grasp, e.g., object and task constraints. However, not all of these factors have had enough emphasis in the implementation of grasping by robots, particularly the constraints introduced by a task, which are critical to the success of a handover. Successful robotic grasping is important if robots are to help humans with tasks. We believe that the results of this work can benefit the wider robotics community, with applications ranging from industrial cooperative manipulation to household collaborative manipulation.