Miracle-dz/UniFAR-FTUs huggingface dataset:
Maternal report of infant negative affect predicts attenuated brain response to own infant

Parent-infant interaction is known to be influenced bidirectionally by parent and infant characteristics. However, it is unclear whether infant temperament affects parents' neural responses to infant stimuli. 85 infants (6-12 months) were filmed in distress-eliciting tasks, which were coded for infants' negative affect. Mothers' reported infant affect was obtained from the Infant Behavior Questionnaire Very Short Form-Revised. Mothers' EEG activity was recorded while passively viewing photos of own, familiarized, and unfamiliar infants. Multiple regression indicated that mothers who reported greater infant negative affect showed a smaller difference in the late positive potential (LPP) response to own infant versus familiarized infant, controlling for researcher-coded infant negative affect. The findings suggest that parents' perceptions of their infant's temperament, but not independent measures of infant temperament, are related to electrocortical indices of emotional attention.
Quantifying the Impact of Cognitive Biases in Question-Answering Systems

Crowdsourcing can identify high-quality solutions to problems; however, individual decisions are constrained by cognitive biases. We investigate some of these biases in an experimental model of a question-answering system. We observe a strong position bias in favor of answers appearing earlier in a list of choices. This effect is enhanced by three cognitive factors: the attention an answer receives, its perceived popularity, and cognitive load, measured by the number of choices a user has to process. While separately weak, these effects synergistically amplify position bias and decouple user choices of best answers from their intrinsic quality. We end our paper by discussing the novel ways we can apply these findings to substantially improve how high-quality answers are found in question-answering systems.
Contrast in the circadian behaviors of an electrodermal activity and bioimpedance spectroscopy

ABSTRACT Probing the electrical response of the human body is minimally invasive and a promising area of investigation for future health care. The electrical responses of individuals may vary depending on daily physiological rhythms or environmental changes, which may hamper their prediction for pathological status. In this study, we observed circadian expressions via both alternating current (AC) and direct current (DC) electrical responses of the human body using bioelectrical impedance analysis (BIA) and electrodermal activity (EDA). In total, 14 healthy adults (9 males and 5 females) participated and were hospitalized for 2 nights with controlled caloric intake, sleep hours and residential conditions. The EDA data showed a significant circadian rhythm, but the BIA data did not show significant modulations during the measurement period. No difference was found between circadian changes in male and female participants. The acrophase of the EDA voltage response showed similar behavior with variations in the heart rate variability, with a resistance minimum occurring at approximately 4 pm, implying that the behavior of the EDA is probably affected by the sympathetic nerve response. Moreover, the resistance of the EDA varied by up to 15% from its mean value, which suggests that circadian variations cannot be neglected for the correct diagnosis of pathological conditions. In contrast, the BIA method did not show this circadian variation but showed independent results over the measurement period. This difference in performance implies that the DC and AC responses of the human body contain different electrophysiological information.
Management of patients with metastatic teratoma with malignant somatic transformation

Purpose of review The purpose of this review is to examine the historical context alongside contemporary studies in order to provide the most current recommendations for the management of patients with metastatic teratoma with malignant somatic transformation (MST). Recent findings The main themes in the recent literature covered herein include prognostic features, the management of early-stage disease, recommended chemotherapeutic and surgical strategies as well as recognized patterns of late relapse. Summary Recent literature, combined with a significant contribution from historical studies, suggests that while MST is uncommon, its aggressive nature coupled with its resistance with traditional germ cell tumor chemotherapies makes it very difficult to manage. The key message is that surgery is recommended in all resectable MST from primary retroperitoneal lymph node dissection for clinical stage I, to radical removal of disease after chemotherapy and when chemotherapy fails. In advanced cases with documented spread of the transformed histologic subtype, systemic therapies targeted to the identified tumor type should be considered.
Strategies for managing hot fl ashes Hormone therapy

Hot fl ashes are the most prevalent and most bothersome symptoms of the menopausal transition and the leading cause for seeking medical attention during that period of a woman’s life. Th ey may last for a few seconds or for several minutes and may occur as frequently as every hour to several times per week. On average, women experience hot fl ashes for a period of 6 months to 2 years, but the symptoms may last up to 10 years or more. Hot fl ashes have been reported by up to 70% of women undergoing natural menopause, and by almost all women undergoing surgical menopause. For many women, these symptoms are mild and can be managed with reassurance and counseling. For others, the symptoms are severe, overwhelming, last for many years, and impair the quality of life. According to a community-based survey of 16,000 women, hot fl ashes occur most often in late perimenopause and among those with a body mass index ≥27. Hot fl ashes are also more common among African Americans and women who are less physically active and have a lower income. Since the publication of the Women’s Health Initiative study in 2002 raised concerns about the long-term safety of hormone therapy (HT), nonhormonal remedies have emerged as potential alternative treatments. A wealth of evidence has accumulated on the effi cacy and safety of these, and various other approaches to the management of hot fl ashes. Th is review will summarize that evidence to help you provide optimal care and assist patients in making informed choices about their treatment.
An investigation on factors influencing electronic banking adoption in private banks versus public banks

Article history: Received Feb 28, 2013 Received in revised format 19 September 2013 Accepted 23 October 2013 Available online December 1 2013 The movement of industrial societies towards implementation of information technology has begun and it has gained moment since early 90 and presently the speed of this movement is well obvious in less developed countries, including Iran. Internet Banking is one of the most tangible trends in today’s electronic commerce. It has direct relationship with the perception of the service qualities not only because of unique absorption of the internet, but also because of ecommerce, acceptance of internet services of banks by clients and the tendency for using such services. This paper investigates different factors influencing on acceptance of electronic banking in private banks versus public banks in a case study of two Iranian banks namely; Eqtesade Novin and Sepah using Technology Acceptance Model (TAM). Correlation test reveals that there was a positive and significant relationship between clients of private and public bank on five factors associated with TAM. In addition, structural equation method was used for investigation of relationships in offered model. In conclusion, all primary and secondary hypotheses for clients of private and public bank were confirmed.
Modeling and Prototyping of an Underactuated Gripper Exploiting Joint Compliance and Modularity

In this study, we present an efficient mathematical representation of soft robotic fingers based on screw theory. Then, we show how the model and its main properties can be exploited in the design phase, and we present an application for an underactuated tendon-driven gripper with a modular structure, in which the joint stiffness values are defined to obtain the desired equivalent stiffness and kinematics manipulability at the fingertips. A distribution of stiffness through the flexible parts of the gripper is fundamental to characterize its overall behavior: The introduced mathematical model enables the gripper designer to analyze how a specific property, e.g., a desired trajectory of the fingertips, a desired overall stiffness, a distribution of contact force, etc., is influenced by the stiffness of its passive joints, and vice-versa evaluating the joint stiffness values allowing to get a desired properties. Joints with different stiffness values can be obtained by regulating three-dimensional-printing parameters and material properties in the manufacturing process. It is possible to design modular grippers with the same mechanical structure, but different behaviours, i.e., different fingertip trajectories, equivalent fingertip stiffness ellipsoids etc. Gripper modules can be easily assembled and disassembled, maintaining the same base, to adapt them to different tasks. The presented model and design guidelines are a first step in the direction of soft grippers that can be optimized for a specific problem.
Changes in brain architecture are consistent with altered fear processing in domestic rabbits

Significance A common feature of all domestic animals is their tame behavior and lack of fear for humans. Consistent with this, we have previously demonstrated that genes with a role in brain or neural development have been particularly targeted during rabbit domestication. Here we show, using high-resolution magnetic resonance imaging, that domestic rabbits have an altered brain architecture consistent with reduced emotional processing, including attention to behaviorally relevant stimulation, such as fear detection, learning, expression, and control, as well as compromised information processing. The results, here based on rabbits, are significant for understanding both domestication-induced reorganization of brain architecture and how adaptions in brain territories and networks supporting emotion, cognition, and behavior coincide with an altered behavioral repertoire. The most characteristic feature of domestic animals is their change in behavior associated with selection for tameness. Here we show, using high-resolution brain magnetic resonance imaging in wild and domestic rabbits, that domestication reduced amygdala volume and enlarged medial prefrontal cortex volume, supporting that areas driving fear have lost volume while areas modulating negative affect have gained volume during domestication. In contrast to the localized gray matter alterations, white matter anisotropy was reduced in the corona radiata, corpus callosum, and the subcortical white matter. This suggests a compromised white matter structural integrity in projection and association fibers affecting both afferent and efferent neural flow, consistent with reduced neural processing. We propose that compared with their wild ancestors, domestic rabbits are less fearful and have an attenuated flight response because of these changes in brain architecture.
Positive psychological interventions for neurological disorders: A systematic review

Objectives: Psychological well-being in people with neurological diseases can be compromised due to brain damage or psychological reactions towards chronic disabilities. This systematic review evaluated the efficacy of positive psychological intervention (PPI) in neurological populations. Methods: Previous studies relevant to this topic were identified by searches in PUBMED, EMBASE, MEDLINE, and PSYCINFO databases from Jan 1980 to August 2017. Results: Of 1361 articles identified, 31 studies were included. Nineteen studies were randomized controlled trials. Sixteen studies had sample sizes of less than 30. Twelve studies were rated as high quality using the National Heart, Lung, and Blood Institute (NHLBI) quality assessment tools. Six therapies were found: mindfulness-based approaches, positive savoring, life summary, expressive-based, hope-based interventions, and character strengths. These interventions were shown to improve quality of life, reduce symptomatic distress, and depressive symptoms. Conclusion: PPIs promote well-being among patients with neurological deficits. For PPIs to be considered as an evidence-based practice, more trials with adequate statistical power are required.
Integrated Silicon Photonic Microresonators: Emerging Technologies

Silicon photonics is becoming the leading technology for photonic integrated circuits (PICs) due to large-scale integration, low cost, and high-volume productions enabled by complementary metal-oxide-semiconductor (CMOS) fabrication process. Thanks to various material and optical characteristics of crystalline silicon, the silicon-on-insulator platform has become the dominant material platform for silicon photonics. Meanwhile, monolithic or heterogeneous integration of other materials on silicon photonic chips, including the silicon nitride (SiN)-on-insulator platform and the III–V-on-silicon platform, are under rapid developments to enhance the functionalities of silicon photonics. Among the myriad of silicon photonic structures for passive and active components, integrated microresonators are promising for a broad range of applications due to their strong resonance field enhancement, narrowband wavelength selectivity, and compact footprints. In this paper, we review the state of the art and our perspectives on emerging technologies based on integrated silicon photonic microresonators in the technology domains of intradatacenter optical interconnects, integrated nonlinear and quantum photonics, and lab-on-a-chip optical biosensing. We specifically review recent progress and our original work in SOI microring-based crossbar switch fabrics; III–V-on-silicon microresonator lasers; silicon-based microresonator nonlinear and quantum sources; and SiN microresonator-based optical biosensors.
A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K+ channels

The human ether-a-go-go–related gene (hERG) encodes a voltage-gated potassium channel that controls repolarization of cardiac action potentials. Accumulating evidence suggests that most disease-related hERG mutations reduce the function of the channel by disrupting protein biogenesis of the channel in the endoplasmic reticulum (ER). However, the molecular mechanism underlying the biogenesis of ERG K+ channels is largely unknown. By forward genetic screening, we identified an ER-located chaperone CNX-1, the worm homologue of mammalian chaperone Calnexin, as a critical regulator for the protein biogenesis of UNC-103, the ERG-type K+ channel in Caenorhabditis elegans. Loss-of-function mutations of cnx-1 decreased the protein level and current density of the UNC-103 K+ channel and suppressed the behavioral defects caused by a gain-of-function mutation in unc-103. Moreover, CNX-1 facilitated tetrameric assembly of UNC-103 channel subunits in a liposome-assisted cell-free translation system. Further studies showed that CNX-1 act in parallel to DNJ-1, another ER-located chaperone known to regulate maturation of UNC-103 channels, on controlling the protein biogenesis of UNC-103. Importantly, Calnexin interacted with hERG proteins in the ER in HEK293T cells. Deletion of calnexin reduced the expression and current densities of endogenous hERG K+ channels in SH-SY5Y cells. Collectively, we reveal an evolutionarily conserved chaperone CNX-1/Calnexin controlling the biogenesis of ERG-type K+ channels.
Interim Buprenorphine Treatment During Delays to Comprehensive Treatment: Changes in Psychiatric Symptoms

Prevalence of depression, anxiety, and mood disorders among individuals with opioid use disorder far exceeds that of the general population. While psychiatric symptoms often improve upon entry into opioid treatment, this has typically been seen with treatments involving psychosocial counseling. In this secondary analysis, we examined changes in psychiatric symptoms during a randomized clinical trial evaluating an interim buprenorphine treatment without counseling among individuals awaiting entry into comprehensive treatment. Waitlisted adults with opioid use disorder (N = 50) were randomized to one of two 12-week conditions: interim buprenorphine treatment (IBT; n = 25) consisting of buprenorphine maintenance using a computerized medication dispenser, with bimonthly clinic visits and technology-assisted monitoring, or waitlist control (WLC; n = 25), wherein participants remained on the waitlist of their local clinic. All participants completed assessments of psychiatric symptoms at intake and Study Weeks 4, 8, and 12. We examined changes on the Beck Anxiety Inventory (BAI), Beck Depression Inventory–II (BDI-II), Brief Symptom Inventory (BSI), and Psychiatric subscale of the Addiction Severity Index (ASI). Significant group-by-time interactions were observed for all measures of psychiatric severity examined: BAI (p < .05), BDI-II (p < .01), 5 BSI subscales (ps < .05), and the ASI Psychiatric subscale (p < .05). On all measures, IBT participants reported significantly reduced psychiatric severity at the 4-, 8-, and 12-week assessments relative to baseline. In contrast, there were no significant changes in psychiatric symptoms among WLC participants. IBT without counseling may improve psychiatric distress among waitlisted individuals with opioid use disorder.
Initial response of phenology and yield components of wheat (Triticum durum L., CIRNO C2008) under experimental warming field conditions in the Yaqui Valley

This work evaluates the experimental warming effects on phenology and grain yield components of wheat in the Yaqui Valley, Sonora, México, using CIRNO C2008 variety from Triticum durum L. , as a model during the cropping cycle of 2016–2017 (December to April). Infrared radiators were deployed to induce experimental warming by 2 °C above ambient crop canopy temperature, in a temperature free-air controlled enhancement system. Temperature was controlled by infrared temperature sensors placed in eight plots which covered a circle of r = 1.5 m starting five days after germination until harvest. The warming treatment caused a reduction of phenophases occurrence starting at the stem extension phenophase. Such phenological responses generated a significant biological cycle reduction of 14 days. Despite this delay, CIRNO C2008 completed its biological cycle adequately. However, plant height under the warming treatment was reduced significantly and differences were particularly observed at the final phenophases of the vegetative cycle. Plant height correlated negatively with spikes length, spikes mass, and number of filled grains. Warming also reduced grain yield in 33%. The warming treatment caused a stress intensity (SI = 1-yield warming/yield control) of 39.4% and 33.2% in biomass and grain yield, respectively. The differences in stress intensities between biomass and grain yield were based on plant height reduction. Grain mass was not affected, demonstrating the crop capability for remobilization and adequate distribution of elaborated substances for the spikes under warming conditions.
Insights into the musculature of the bonobo hand

The human hand is well known for its unique dexterity which is largely facilitated by a highly mobile, long and powerful thumb that enables both tool manufacturing and use, a key component of human evolution. The bonobo (Pan paniscus), the closest extant relative to modern humans together with the chimpanzee (Pan troglodytes), also possesses good manipulative capabilities but with a lower level of dexterity compared with modern humans. Despite the close phylogenetic relationship between bonobos and humans, detailed quantitative data of the bonobo forelimb musculature remains largely lacking. To understand how morphology may influence dexterity, we investigated the functional anatomy of the bonobo hand using a unique sample of eight bonobo cadavers, along with one chimpanzee and one human (Homo sapiens) cadaver. We performed detailed dissections of unembalmed specimens to collect quantitative datasets of the extrinsic and intrinsic hand musculature, in addition to qualitative descriptions of the forelimb muscle configurations, allowing estimation of force‐generating capacities for each functional group. Furthermore, we used medical imaging to quantify the articular surface of the trapeziometacarpal joint to estimate the intra‐articular pressure. Our results show that the force‐generating capacity for most functional groups of the extrinsic and intrinsic hand muscles in bonobos is largely similar to that of humans, with differences in relative importance of the extensors and rotators. The bonobo thumb musculature has a lower force‐generating capacity than observed in the human specimen, but the estimated maximal intra‐articular pressure is higher in bonobos. Most importantly, bonobos show a higher degree of functional coupling between the muscles of the thumb, index and lateral fingers than observed in humans. It is conceivable that differentiation and individualization of the hand muscles rather than relative muscle development explain the higher level of dexterity of humans compared with that of bonobos.
Retinal Pericytes: Characterization of Vascular Development-Dependent Induction Time Points in an Inducible NG2 Reporter Mouse Model

ABSTRACT Purpose/aim of the study: In the retina, defects in pericytes (PCs) function/loss are associated with various complications; however, the exact pathological mechanisms are still not fully elucidated. Following the behavior of retina-resident PCs during health and disease will reveal new insights for both the understanding of pathological mechanisms and the development of new regenerative therapies for the treatment of retinopathies. The main goal of this study is to determine whether the NG2-reporter mouse (NG2CreERTM-eGFP) is a suitable model to study the fate of retina-resident PCs. Material and methods: Vascular development-dependent reporter induction in retinal PCs was evaluated at different time points [(a) > P21, (b) < P21, and (c) P1 to > P21)] and additionally four different modes of application were tested. Reporter expression was evaluated by enhanced green fluorescent protein (eGFP) immunofluorescence by confocal microscopy and induction efficiency was calculated by analyzing NG2-expressing PCs in comparison to eGFP-labeled PCs in the three capillary layers. Results: eGFP-positive PCs were detected in the three retinal capillary layers at all time points and administration routes tested. Multiple tamoxifen (TAM) applications in adult (> P21) NG2CreERTM-eGFP mice resulted in 3.59% eGFP-positive PCs. 2.37% eGFP-labeled PCs were detected after single intraperitoneal TAM injections at early postnatal days (P2/P5); however, just 1.61% PCs revealed reporter expression upon activation via the lactating mother (P4–P7). The highest number of eGFP-labeled PCs (7.09%) was detected following triple TAM administrations (P10–P12). The number of reporter-positive PCs doubled using homozygous animals. Conclusion: Despite low recombination efficiency in the used PC-specific fate mapping mouse model, changes in NG2 promoter activity of PCs during vascular development are indicated by single and multiple TAM inductions at different developmental time points. Nevertheless, these findings need further confirmation in up-coming studies by using homozygous NG2CreERTM-eGFP mice and additionally by mating the NG2CreERTM with a different reporter mouse to increase the low recombination efficiency.