Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative antiplaque and antigingivitis effectiveness of a chlorhexidine and an essential oil mouthrinse: 6-month clinical trial.

OBJECTIVES The objective of this study was to compare the antiplaque and antigingivitis effectiveness and the side-effect profiles of an essential oil-containing mouthrinse and a chlorhexidine-containing mouthrinse. MATERIAL AND METHODS One hundred and eight qualifying subjects, aged 20-57 years, were randomized into three groups: essential oil mouthrinse (ListerineAntiseptic); 0.12% chlorhexidine mouthrinse (Peridex); or 5% hydroalcohol negative control. At baseline, subjects received a complete oral soft tissue examination and scoring of the Loe-Silness gingival index (GI), Quigley-Hein plaque index (PI), Volpe-Manhold calculus index (CI), and Lobene extrinsic tooth stain index (SI). Following a complete dental prophylaxis, subjects started rinsing twice daily with their respective mouthrinse as an adjunct to their usual mechanical oral hygiene procedures. One of the rinses on each weekday was supervised. Subjects were reexamined at 3 and 6 months. The treatment groups were compared with respect to baseline demographic and clinical variables. The primary efficacy variables were GI and PI. Intergroup differences for all clinical variables were tested at 3 and 6 months using appropriate statistical procedures. RESULTS All of the 108 randomized subjects were evaluable at 3 months, and 107 subjects were evaluable at 6 months. There were no statistically significant differences among the three groups at baseline, with the exception that the control group PI was significantly lower than that of the essential oil group (p<0.05) and the chlorhexidine group (p<0.001), and the essential oil mouthrinse group had a significantly greater number of subjects than the control group with body region SI scores > or =1.0 (p=0.021). At 6 months, the essential oil and chlorhexidine mouthrinses produced statistically significant (p<0.001) GI reductions of 14.0% and 18.2%, respectively, and statistically significant (p<0.001) PI reductions of 18.8% and 21.6%, respectively, compared with the control and were not statistically significantly different from each other with respect to plaque and gingivitis reduction. The chlorhexidine mouthrinse group had significantly more calculus and extrinsic tooth stain than either the essential oil mouthrinse group or the control group. CONCLUSION This 6-month controlled clinical study demonstrated that the essential oil mouthrinse and the chlorhexidine mouthrinse had comparable antiplaque and antigingivitis activity. Insofar as side effects associated with the chlorhexidine mouthrinse may limit patient compliance, it is suggested that each product can have a distinct role in the management of patients with periodontal diseases.
Anterior perirhinal cortex kindling produces long‐lasting effects on anxiety and object recognition memory

Temporal lobe epilepsy (TLE) is frequently accompanied by memory impairments and, although their bases are unknown, most research has focused on the hippocampus. The present study investigated the importance of another medial temporal lobe structure, the perirhinal cortex (Prh), in changes in memory in TLE using kindling as a model. Rats were kindled twice daily with anterior Prh stimulation until three fully generalized seizures were evoked. Beginning 7 days later and on successive days, rats were tested in an elevated plus maze, a large circular open field, an open field object exploration task and a delayed‐match‐to‐place task in a water maze in order to assess anxiety‐related and exploratory behaviour, object recognition memory and spatial cognition. Kindling increased anxiety‐related behaviour in both the elevated plus and open field mazes and disrupted spontaneous object recognition but spared all other behaviours tested. These results are consistent with other findings indicating a greater role for the Prh in object memory and emotional behaviour than in spatial memory and contrast with the selective disruption of spatial memory produced by dorsal hippocampal kindling. The site‐selectivity of the behavioural disruptions produced by kindling indicates that such effects are probably mediated by changes particular to the site of seizure initiation rather than to changes in the characteristic circuitry activated by limbic seizure generalization. Further investigation of the behavioural effects of Prh kindling may be useful for studying the mechanisms of mnemonic and affective dysfunction associated with TLE and offer insights into bases for variability in such dysfunction across patients.
Molecular Dopants and High Mass Dopants for HALO and Extension Implantation

Diffusion-less activation were realized for the 650degC SPE, >1300degC flash and 900degC spike anneals. For pSDE all boron dopant species (BF<sub>2</sub>, B<sub>10</sub>H<sub>14</sub> and B<sub>18</sub>H<sub>22</sub>) achieved high quality junctions with flash annealing. With 900degC spike either B<sub>10</sub>H<sub>14</sub> or B<sub>18</sub>H<sub>22</sub> can be used while with 650degC SPE annealing only B<sub>18</sub>H<sub>22</sub> can be used. For pHALO using In no difference in activation level could be seen but significant differences in junction leakage was observed. No difference between BF<sub>2</sub> and B<sub>10</sub>H<sub>14</sub> HALO activation could be seen for each annealing condition and SPE annealing resulted in the worse activation level. For nSDE with flash annealing As, As<sub>2</sub> and Sb activation levels were similar while P<sub>2</sub> was 25% better. With SPE and 900degC spike Sb gave the best activation. For nHALO As, As<sub>2</sub> and Sb activation levels were similar for all annealing conditions with SPE resulting in 2x lower activation. Doubling the As<sub>2</sub> dose improved SPE activation by 2x.
The effect of cisterna chyli ablation combined with thoracic duct ligation on abdominal lymphatic drainage.

OBJECTIVE To evaluate the effect of cisterna chyli ablation (CCA) and thoracic duct ligation (TDL) on abdominal lymphatic drainage in normal dogs. STUDY DESIGN Experimental study. ANIMALS Nine female beagle dogs. METHODS TDL was performed in 3 dogs and was combined with CCA (CCA-TDL) and local omentalization in 6 dogs. Contrast lymphangiography was attempted in all dogs immediately before and after TDL. Dogs were reanesthetized at 31-37 days for lymphatic studies by new methylene blue (NMB) injection into a mesenteric lymph node and by contrast lymphangiography. RESULTS In 6 CCA-TDL dogs, 2 had direct shunting of contrast from the lymphatic system into major abdominal veins, 3 had contrast material that dissipated into abdominal vessels within the mesenteric root, and 1 had shunting into the azygous vein. NMB was not observed within the omental pedicle after CCA-TDL. Chylous drainage was by the azygous vein in all 3 TDL dogs. CONCLUSIONS CCA-TDL disrupted chylous drainage to the thoracic duct and resulted in direct intraabdominal lymphaticovenous anastomoses identified by shunting of lymphatic flow directly into the abdominal vasculature in 5 of 6 CCA-TDL dogs. Omentalization of the cisternal ablation site was not beneficial in augmenting extrathoracic lymphatic drainage and is not recommended with CCA-TDL. CLINICAL RELEVANCE CCA-TDL represents a novel approach to surgical redirection of chylous drainage to the venous circulation outside of the thorax and may be useful in the treatment of spontaneous chylothorax in the dog.
Association of autonomic dysfunction and clozapine

Background Antipsychotic medications cause a wide range of adverse effects and have been associated with sudden death in psychiatric patients. Aims To supply power spectral analysis of heart rate variability as a tool to examine the arrythmogenic effects of neuroleptics. Method Heart rate analysis was carried out in patients with schizophrenia on standard doses of neuroleptic monotherapy − 21 were on clozapine, 18 on haloperidol and 17 on olanzapine – and in 53 healthy subjects. Results Patients with schizophrenia on clozapine had significantly higher heart rate, lower heart rate variability and lower high-frequency and higher low-frequency components compared with patients on haloperidol or olanzapine and matched control subjects. Prolonged QTc intervals were more common in patients than controls. Conclusions Patients treated with neuroleptic medications, especially clozapine, showed autonomic dysregulation and cardiac repolarisation changes. Physicians should be aware of this adverse reaction.
Face recognition in uncontrolled environments

This thesis concerns face recognition in uncontrolled environments in which the images used for training and test are collected from the real world instead of laboratories. Compared with controlled environments, images from uncontrolled environments contain more variation in pose, lighting, expression, occlusion, background, image quality, scale, and makeup. Therefore, face recognition in uncontrolled environments is much more challenging than in controlled conditions. Moreover, many real world applications require good recognition performance in uncontrolled environments. Example applications include social networking, human-computer interaction and electronic entertainment. Therefore, researchers and companies have shifted their interest from controlled environments to uncontrolled environments over the past seven years. In this thesis, we divide the history of face recognition into four stages and list the main problems and algorithms at each stage. We find that face recognition in unconstrained environments is still an unsolved problem although many face recognition algorithms have been proposed in the last decade. Existing approaches have two major limitations. First, many methods do not perform well when tested in uncontrolled databases even when all the faces are close to frontal. Second, most current algorithms cannot handle large pose variation, which has become a bottleneck for improving performance. In this thesis, we investigate Bayesian models for face recognition. Our contributions extend Probabilistic Linear Discriminant Analysis (PLDA) [Prince and Elder 2007]. In PLDA, images are described as a sum of signal and noise components. Each component is a weighted combination of basis functions. We firstly investigate the effect of degree of the localization of these basis functions and find better performance is obtained when the signal is treated more locally and the noise more globally. We call this new algorithm multi-scale PLDA and our experiments show it can handle lighting variation better than PLDA but fails for pose variation. We then analyze three existing Bayesian face recognition algorithms and combine the advantages of PLDA and the Joint Bayesian Face algorithm [Chen et al. 2012] to propose Joint PLDA. We find that our new algorithm improves performance compared to existing Bayesian face recognition algorithms. Finally, we propose Tied Joint Bayesian Face algorithm and Tied Joint PLDA to address large pose variations in the data, which drastically decreases performance in most existing face recognition algorithms. To provide sufficient training images with large pose difference, we introduce a new database called the UCL Multi-pose database. We demonstrate that our Bayesian models improve face recognition performance when the pose of the face images varies.
Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele.

BACKGROUND Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathione transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE genotypes to investigate their role as susceptibility genes for late-onset AD (LOAD). METHODS We included 210 LOAD patients and 228 healthy controls matched for age, sex, and educational level in our case-control genetic association study. GSTM1 and GSTT1 genotypes were studied by conventional PCR, whereas GSTP1 and ApoE genotypes were determined by real-time PCR on the LightCycler. RESULTS We found a significant association between LOAD and the GSTP1*C allelic variant [odds ratio (OR) = 1.9; P < 0.05], but no association between the GSTM1 and GSTT1 deleted genotypes and LOAD. In addition, a preliminary result suggested that carriers of both the GSTP1*C and ApoE epsilon4 allelic variants were at increased risk of LOAD (OR = 19.98; P < 0.0001). CONCLUSION The GSTP1*C allelic variant should be considered a candidate for LOAD, particularly in persons having the ApoE epsilon4 allelic variant, because the GSTP1 and ApoE gene products are implicated in oxidative stress and apoptosis processes leading to beta-amyloid-mediated neurodegeneration.
Induced Hypothermia Preserves the Functional Enterocyte Mass in A Porcine Multiple Trauma Model: Voluntary Retraction.

Induced Hypothermia Preserves the Functional Enterocyte Mass in A Porcine Multiple Trauma Model: Voluntary Retraction The authors voluntarily retract this article, as some of the results have been published previously as part of a larger comprehensive study and were inadvertently used in this publication. The authors apologize for unintentionally permitting duplicated data to reach the scientific community. REFERENCE Fröhlich M, Maegele M, Hildebrand F, Weuster M, Mommsen P, Mohr J, Witte I, Pfeifer R, Feichtinger G, Keibl C, et al.: Induced hypothermia preserves the functional enterocyte mass in a porcine multiple trauma model. Shock 2016; Apr 6. [Epub ahead of print]
Quality of life, age of onset of alcohol use and alcohol use disorders in adolescence and young adulthood: Findings from an Australian birth cohort.

INTRODUCTION AND AIMS Alcohol consumption among adolescents and young adults is a persistent community concern. Little is known about the short-term effects on the young adult drinker's quality of life (QOL), particularly prior to the first use of alcohol and the effect of alcohol consumption on subsequent QOL assessments. There is a need to know more about the QOL of those who decide to use alcohol in adolescence and the effect of alcohol consumption on young adult QOL. DESIGN AND METHODS This is a prospective longitudinal study of a birth cohort. Data were taken from the 14- and 21-year follow ups. At both time points, QOL was indicated by a measure of happiness and satisfaction. Alcohol use was also measured at 14- and 21-year follow ups. At the 21-year follow up, alcohol use disorder (AUD) was assessed using the Composite International Diagnostic Interview. RESULTS At the 14-year follow up, there was a strong association between QOL and quantity of alcohol consumed. QOL at 14 years also predicted more frequent alcohol use at 21 years of age. Poor QOL at 14 years was a strong predictor of earlier age of onset of an AUD. However, when age of onset of AUD was used to predict subsequent QOL, the associations were weak and inconsistent. DISCUSSION AND CONCLUSION Poor QOL was associated with the early age of onset of alcohol use and AUDs. Addressing adolescent and young adult QOL may reduce the early onset of alcohol use and its potential for harm.
Comparison of Four Diagnostic Methods for Detection and Relative Quantification of Haemonchus contortus Eggs in Feces Samples

We compared four methods for identification of Haemonchus contortus eggs. With increased trade in animals within and between countries and continents, it has become important to correctly identify H. contortus eggs in fecal samples. To validate the outcome of diagnostic tests, sheep feces (n = 38) were collected from naturally infected flocks in Sweden. Subsamples were analyzed with (a) McMaster egg counting; (b) differential counting of eggs after staining with peanut agglutinin (PNA); (c) detection of DNA following amplification by real-time quantitative polymerase chain reaction (qPCR); and (d) loop-mediated isothermal amplification (LAMP). Differences between similar tests (microscopic and molecular) and SD (±SD) were analyzed with Bland–Altman plots and Spearman rank correlation. Strongylid egg counts ranged from 200 to 12,100 eggs per gram (epg) (mean epg ± SD = 1,278 ± 2,049). Microscopy showed presence of H. contortus eggs in 27 (73%) unstained samples and in 28 (76%) samples stained with PNA, whereas 29 samples (78%) tested positive in LAMP and 34 (91%) in qPCR analysis. The cycle threshold (Ct) values with LAMP ranged between 13 and 38 (mean ± SD = 21 ± 7), and those in qPCR between 25 and 49 (mean ± SD = 33 ± 6). In the LAMP and qPCR analyses, seven (19%) and three (8%) samples, respectively, had a cycle threshold (Ct) >35, whereas no reactions were observed in eight (22%) and three (8%) samples, respectively. There was good agreement between the diagnostic tests based on microscopic examination and DNA detection, although the molecular tests were more sensitive. The bias between the microscopy methods (−4.2 ± 11) was smaller than for the molecular tests (−9.8 ± 10). The observed ranking in terms of test sensitivity was: McMaster counting by conventional microscopy < PNA < LAMP < qPCR. In conclusion, H. contortus can be identified by McMaster counting, without major mistakes regarding false positive results. However, molecular methods provide the capacity to diagnose H. contortus eggs with increased accuracy. This is essential when animals are investigated in quarantine or in studies evaluating anthelmintic treatment efficacy. These methods could also be applied to fecal samples from wildlife to investigate nematode transmission between wildlife and livestock.
Similar response to adalimumab in patients with active Crohn's disease either naive to biologic agents or with prior loss of response or intolerance to infliximab.

UNLABELLED The aim of this study was to investigate the efficacy of adalimumab, in patients with moderately active Crohn's disease (CD), either naive to biologic agents or with prior loss of response or intolerance to infliximab. MATERIAL AND METHOD A total number of 30 patients with moderately active CD (14 men, 16 women, aged 38.5 +/- 14.4 yr) either naive to biologic agent treatment (19 pts (65%)) or with loss of response or intolerance to infliximab (11 pts (35%)), were enrolled to 4-wk trial with treatment with subcutaneous adalimumab 160 mg injection at week 0, 80 mg at week 2 and then 40 mg every other week. Outcome measures included the ability to tolerate adalimumab and clinical remission (defined as a CDAI score < or =150 points) and clinical response (defined as a decrease in the CDAI) > or =70 points). Eleven patients (37%) were smokers, 5(16%) ex-smokers and 14 (47%) non-smokers. Five patients (16%) had a positive family history for IBD. Duration of disease was 10.7 +/- 8.1 yr. Coexistence of extraintestinal manifestations was noticed in 12 (40%) patients. Vienna Classification of CD was A1=24 (80%), A2=6 (20%), L1=8 (26.7%), L2=6 (20%), L3=15 (50%), L4=1 (3.3%), B1=15 (50%), B2=5 (16.7%), B3=10 (33.3%). RESULTS Remission was observed in 19 (63.3%) and clinical response in 9 (30%) patients. Two patients (6.7%) showed no response. No significant differences between patients with loss of response or intolerance to infliximab and the group of naive patients were noticed. Comparison between smokers and non smokers revealed significant difference in the response rate in favour of non-smokers (P < 0.002). A trend (P = 0.064) towards a significant difference in the response rate of the group of smokers according to the number of cigarettes smoked per day was observed. Patients with short duration of disease (<10 yr) had significantly better response compared to the group of patients with long (>10 yr) duration of disease. Similarly, patients with extraintestinal manifestations showed significantly better response (P = 0.044). None of the patients in both groups experienced acute or delayed hypersensitivity reactions during treatment with adalimumab. CONCLUSION Adalimumab is well tolerated and appears to be a beneficial option for patients with CD who have not previously treated with biologic agents or have lost their response to, or cannot tolerate infliximab, with non-smokers, patients with short duration of CD, and patients with extraintestinal manifestations having a better clinical response.
Influence of Vacuum Annealing on Structural, Optical, Electrical, and Magnetic Properties of Zn $_{0.94}$Co $_{0.05}$Al $_{0.01}$O Diluted Magnetic Semiconductor Thin Films

The Zn<sub>0.94</sub>Co<sub>0.05</sub>Al<sub>0.01</sub>O diluted magnetic semiconductor (DMS) thin films were made by rf magnetron co-sputtering, and annealed in vacuum at 500°C (for 0, 20, 40, and 80 min, respectively). The films have a single ZnO wurtzite structure with -axis preferred orientations, without any segregated secondary phase, and Co<sup>2+</sup> ions substitute tetrahedrally coordinated Zn<sup>2+</sup> ions site. The as-grown film is insulating and in a state of tensile stress parallel to the c-axis. After annealing in vacuum, the films have tensile stresses parallel to the (002) plane, and become conductive; moreover, the carrier concentrations increase with increasing the annealing time. The as-grown film possesses the room-temperature ferromagnetism (RTFM) and the saturation magnetization (M<sub>s</sub>) is 0.8 μ<sub>B</sub>/Co. As the film is annealed in vacuum, the value of M<sub>s</sub> is reduced first then enhanced with the increase of annealing time.
“I want a normal life like everyone else”: Daily life of asylum seekers in Iceland

Abstract Aim: An ever-increasing number of people seek asylum in Iceland. The wait for resolution on application for asylum can take up to three years. During this time participation in daily occupations is disrupted. This study was carried out to gain an understanding of the experience of living as an asylum seeker in Iceland. It explored asylum seekers’ opportunities for participation in occupations as well as their overall experiences while waiting for the processing of their application. Methods: Eleven semi-structured interviews were conducted with nine participants, of whom six were asylum seekers. A constructivist grounded theory approach was applied to categorize and synthesize data. Results: Four major categories emerged that reflected the participants’ difficult living conditions, lack of opportunities for participation, lack of belonging, and feelings of powerlessness. The long processing time of their applications was enormously stressful as well as not being in charge of one’s life, living conditions, or income. Conclusion: The results indicate that the long processing time of application for asylum has deteriorating effects on health. In order to promote asylum seekers’ well-being and occupational rights attention needs to be focused on their living conditions and opportunities for participation in meaningful occupations, including work.