Miracle-dz/UniFAR-FTUs huggingface dataset:
Using a learning coach to teach residents evidence-based medicine.

BACKGROUND AND OBJECTIVES Medical educators have used multiple interventions to teach evidence-based medicine (EBM) and information mastery. Most of these interventions are applied uniformly to a group of residents. We developed a curriculum to increase residents' EBM and information mastery skills that would meet individual learning needs. METHODS Two cohorts of second year residents (n=26) in the Family Medicine Residency Program at Brown University participated in the intervention. We delivered the curriculum through monthly individual meetings with a learning coach over 1 year. Before and after participating, residents completed a survey assessing their attitudes toward EBM and a quiz assessing their knowledge of EBM. Semi-structured interviews with each resident were done after the intervention and analyzed using qualitative methods. RESULTS At the conclusion of our intervention, residents' attitudes toward EBM and information mastery were overwhelmingly positive, EBM knowledge quiz scores increased by 31.8%, and reported use of EBM in real time during patient encounters increased. CONCLUSIONS An intervention using a learning coach to provide one-on-one EBM and information mastery instruction to residents improved residents' attitudes, knowledge, and use of both in the clinical setting.
PENGARUH TINGKAT BAGI HASIL, INFLASI, DAN KURS DOLLAR TERHADAP DANA PIHAK KETIGA (STUDI PADA BANK MUAMALAT INDONESIA (BMI) TAHUN 2011-2015).[SKRIPSI]

Perbankan merupakan sektor yang sangat penting peranannya di dalam pembangunan nasional baik sebagai perantara maupun agen pembangunan. Begitu juga dengan perkembangan perbankan syariah di Indonesia yang mengalami peningkatan, jumlah Bank Syariah dan jumlah jaringan kantor cukup meningkat dan ini tentu saja membuat Dana Pihak Ketiga (DPK) mengalami peningkatan. Keberadaan bank syariah sendiri dalam beberapa tahun terakhir telah menjadi salah satu alternatif bagi masyarakat pasca perbankan nasional. Penelitian ini dilakukan untuk mengetahui tingkat bagi hasil, inflasi dan kurs dollar dalam mempengaruhi dana pihak ketiga. Analisis dilakukan dengan menggunakan analisis regresi berganda dengan bantuan SPSS. Hasil penelitian menunjukan bahwa secara bersama-sama (uji f) tingkat bagi hasil, inflasi dan kurs dollar secara berpengaruh terhadap dana pihak ketiga sedangkan dari hasil uji t tingkat bagi hasil berpengauh terhadap dana pihak ketiga, inflasi berpengaruh terhadap dana pihak ketiga, dan kurs dollar tidak berpengaruh terhadap dana pihak ketiga.
The Value of Needle Renal Allograft Biopsy I. A Retrospective Study of Biopsies Performed During Putative Rejection Episodes

Following renal transplantation, immunosuppression is usually increased to treat presumed rejection episodes. However, a) many conditions mimic rejection in the post-transplant period, and b) many rejection episodes are irreversible. As increased immunosuppressive therapy is associated with an increased risk of infection, it would be ideal to limit antirejection therapy to only the rejection episodes that are reversible. The role of percutaneous allograft biopsy was studied as an aid to decide which patients to treat for rejection, to limit unnecessary immunosuppression and to predict allograft survival. One hundred thirty-five patients with suspected rejection underwent 206 allograft biopsies without complication. Two hundred four biopsies were available for study. Biopsies were coded on a 1–4 scale (minimal, mild, moderate, severe) for acute and chronic tubulointerstitial infiltrate and vascular rejection, as well as no rejection (e.g., recurrence of original disease). Treatment decisions were made on the basis of the biopsy combined with clinical data. All patients have been followed two years and outcome correlated with biopsy findings (death, nephrectomy, and return to dialysis defined as kidney loss). The results were the following: 1) biopsies represented changes within the kidney. Of 16 kidneys removed within one month of biopsy, no nephrectomy specimen showed less rejection than that seen on biopsy. 2) Eighty-one biopsies (39.7%) led to tapering or not increasing immunosuppression (either no rejection, minimal rejection, or irreversible changes). 3) Kidneys having either severe acute or chronic vascular rejection (<30% function at three months) had significantly (p < 0.05) decreased survival three to 24 months postbiopsy than those with minimal or mild vascular rejection or tubulointerstitial infiltrate (83% function at three months). 4) Kidneys with moderate chronic vascular rejection and those with severe acute tubulointerstitial infiltrate had significantly (p < 0.05) decreased survival at six to 24 months. 5) Kidneys with moderate chronic vascular rejection (MCV) without an acute infiltrate (ATI) had significantly better survival than those having both MCV and ATI. 6) Similarly, kidneys having severe ATI alone had better survival than those with ATI plus vascular rejection. It was concluded that a) percutaneous allograft biopsy can be done without graft loss or infection; b) biopsy represents changes throughout the kidney; c) biopsy aids in deciding when to treat for rejection and in deciding when to withhold increased immunosuppression, and d) allograft biopsy predicts the outcome of treatment of a rejection episode.
Development and implementation of a pharmacist-managed, neonatal and pediatric, opioid-weaning protocol.

OBJECTIVES To compare the length of wean and abstinence severity in neonatal and pediatric patients with neonatal abstinence syndrome or iatrogenic opioid dependence treated with a pharmacist-managed, methadone-based protocol compared with physician-managed patients treated with either methadone or dilute tincture of opium (DTO). METHODS This was a prospective, single-centered, interventional evaluation of 54 pharmacist-managed patients versus 53 retrospective, physician-managed patients. Wean duration and severity of neonatal abstinence syndrome were compared between groups using the Student t test. RESULTS Significantly shorter wean duration in in utero-exposed pharmacist-managed patients compared with patients on physician-managed DTO (11.7 days vs 24.2 days, p < 0.001), but not compared with patients on physician-managed methadone (11.7 days vs 47 days, p = 0.101). No statistically significant difference was seen in wean duration in iatrogenic-exposed pharmacist-managed patients compared with patients on either physician-managed DTO or methadone (8.69 days vs 14 days, p = 0.096) and (8.69 days vs 9.82 days, p = 0.34), respectively. There were significantly fewer abstinence scores >12 in pharmacist-managed patients versus physician-managed DTO, but not physician-managed methadone (2.05 vs 17.3, p = 0.008 and 2.05 vs 74.3, p = 0.119, respectively). Significantly fewer abstinence scores ≥8 × 3 consecutively were seen in pharmacist-managed patients compared with patients on either physician-managed DTO or methadone (2.89 vs 11.9, p = 0.01 and 2.89 vs 24, p < 0.001, respectively). CONCLUSIONS Use of a pharmacist-managed, methadone-based weaning protocol standardizes patient care and has the potential to decrease abstinence severity and shorten duration of wean versus physician-managed patients exposed to opioids in utero. Additionally, a methadone wean of 10% to 20% per day was well tolerated in both neonatal and pediatric patients.
Intracranial Aneurysm Surgery and its Future

Mr Maurice-Williams and Mr Lafuente (November 2003 JRSM1) must be congratulated for their erudite account of issues arising during the senior author's long and august career in neurovascular surgery. However, in the wake of the International Subarachnoid Aneurysm Trial (ISAT2) we believe their views regarding the future mode of treatment of intracranial aneurysms to be somewhat ill-founded.
Probing the Structure of the S105 Hole

ABSTRACT For most phages, holins control the timing of host lysis. During the morphogenesis period of the infection cycle, canonical holins accumulate harmlessly in the cytoplasmic membrane until they suddenly trigger to form lethal lesions called holes. The holes can be visualized by cryo-electron microscopy and tomography as micrometer-scale interruptions in the membrane. To explore the fine structure of the holes formed by the lambda holin, S105, a cysteine-scanning accessibility study was performed. A collection of S105 alleles encoding holins with a single Cys residue in different positions was developed and characterized for lytic function. Based on the ability of 4-acetamido-4′-((iodoacetyl) amino) stilbene-2,2′-disulfonic acid, disodium salt (IASD), to modify these Cys residues, one face of transmembrane domain 1 (TMD1) and TMD3 was judged to face the lumen of the S105 hole. In both cases, the lumen-accessible face was found to correspond to the more hydrophilic face of the two TMDs. Judging by the efficiency of IASD modification, it was concluded that the bulk of the S105 protein molecules were involved in facing the lumen. These results are consistent with a model in which the perimeters of the S105 holes are lined by the holin molecules present at the time of lysis. Moreover, the findings that TMD1 and TMD3 face the lumen, coupled with previous results showing TMD2-TMD2 contacts in the S105 dimer, support a model in which membrane depolarization drives the transition of S105 from homotypic to heterotypic oligomeric interactions.
Picking BarbieTM’s Brain: Inherent Sex Differences in Scientific Ability?

The idea that the underrepresentation of women in scientific fields stems from inherent sex differences in scientific abilities has recently re-emerged. We critically examine the argument for biological differences in these abilities, focusing on two central claims: 1) There exist measurable sex differences in mathematical and scientific aptitude, and 2) biological predispositions underlie these differences. A review of the research reveals that findings of differences in math and science performance are not reliable and depend on the measures used. Furthermore, the key evidence for biological predispositions comes from poorly designed studies with equivocal findings. Therefore, our review indicates that the underrepresentation of women in scientific fields cannot be explained by biological sex differences.
Characteristics and clinical outcomes of head-injured cyclists with and without helmets in urban and rural areas of Taiwan: A 15-year study

ABSTRACT Objective: Bicycle riding is increasingly popular in Taiwan, but the number of cyclists injured and cyclists' death rates are both increasing. The aim of this study was to investigate the different characteristics and clinical outcomes of traffic accident–related head injuries among cyclists in urban and rural areas. Methods: Records of 812 patients (533 urban and 279 rural) admitted to 27 hospitals in Taipei City and Hualien County as the result of a traumatic head injury while bicycling between 1998 and 2013 were retrieved for study. Demographics, details about the accident, protective helmet use, and clinical outcomes were then subjected to analysis. Results: Urban victims were more likely to be injured during morning and early evening rush hours and rural victims during the day; most urban victims were between 19 and 34 years of age and injured in the slow lane; rural victims tended to be younger or older and were injured in the fast lane (all P ≤.001). Riders who wore a helmet were less likely to suffer loss of consciousness (odds ratio [OR] = 0.31), amnesia (OR = 0.069), neurological disorders (OR = 0.205), or facial fractures (OR = 0.369). Older age, more severe head injuries, and bicycle–motor vehicle collisions influenced the severity of symptoms on admission and the residual effects at discharge. Conclusions: Differences in the characteristics of injuries in urban and rural areas and the utilization of protective helmets may help government authorities adopt appropriate policies to promote safer and more enjoyable cycling.
Organizational Justice in Performance Appraisal System and Work Performance: Evidence from an Emerging Market

This study aimed at extending the literature of the effect of performance appraisal on productivity and employees by connecting the employees’ perception on fair performance appraisal and organizational justice-considered practices to job satisfaction and work performance. Prior studies did not explore much this relation due to the geographical sample limitation and governance practice context. Participants of this research were employees of large and well-established companies, which were considered to have well and transparent appraisal systems and a perfect recently context to find the effect of organizational justice conflict. Questionnaires were used and processed with factor analysis and regression to examine the simultaneous effects of few independent variables on a dependent variable. The results reveal that the interactional justice has more influence than other types of organizational justice in evaluating employee’s performance, which is contrary with previous researches. Employees are more concerned on interaction during and after the evaluation process. They are keen on knowing how they have been evaluated and what the feedback of their superior is after the performance appraisal process. It provides strong support for the relationship between employee perception of organizational justice in performance appraisal system and work performance. It also supports a significant relationship between performance appraisal satisfaction and work performance. The important implication for organization is a pivotal role of the employees’ perceptions of the success or failure of a system. Therefore, the management has to keep in view the perceptions of their employees, while designing or modifying the appraisal system.
Geometric optimisation on positive definite matrices for elliptically contoured distributions

Hermitian positive definite matrices (HPD) recur throughout statistics and machine learning. In this paper we develop \emph{geometric optimisation} for globally optimising certain nonconvex loss functions arising in the modelling of data via elliptically contoured distributions (ECDs). We exploit the remarkable structure of the convex cone of positive definite matrices which allows one to uncover hidden geodesic convexity of objective functions that are nonconvex in the ordinary Euclidean sense. Going even beyond manifold convexity we show how further metric properties of HPD matrices can be exploited to globally optimise several ECD log-likelihoods that are not even geodesic convex. We present key results that help recognise this geometric structure, as well as obtain efficient fixed-point algorithms to optimise the corresponding objective functions. To our knowledge, ours are the most general results on geometric optimisation of HPD matrices known so far. Experiments reveal the benefits of our approach---it avoids any eigenvalue computations which makes it very competitive.
Supervisory Control of Multiple Robots: Human-Performance Issues and User-Interface Design

The purpose of this paper is to review research pertaining to the limitations and advantages of supervisory control for unmanned systems. We identify and discuss results showing technologies that mitigate the observed problems such as specialized interfaces, and adaptive systems. In the report, we first present an overview of definitions and important terms of supervisory control and human-agent teaming. We then discuss human performance issues in supervisory control of multiple robots with regard to operator multitasking performance, trust in automation, situation awareness, and operator workload. In the following sections, we review research findings for specific areas of supervisory control of multiple ground robots, aerial robots, and heterogeneous robots (using different types of robots in the same mission). In the last section, we review innovative techniques and technologies designed to enhance operator performance and reduce potential performance degradations identified in the literature.
A novel method for real-time wafer positioning during transfer process

This study proposed a novel method for real-time detection of wafer position on a robot blade during the transfer process. The wafer positioning system comprises two line-shaped beams spreading toward a scattering surface on the way of wafer transfer. The images taken from a CCD (charge coupled device) camera mounted above the scattering surface are analyzed, and the instant position of the wafer center on the robot blade during the transfer process can be determined after image processing. The precision for the proposed wafer center detection is about 0.15mm according to the preliminary experimental results.
Public-Key Cryptosystem Based on Isogenies

A new general mathematical problem, suitable for publickey cryptosystems, is proposed: morphism computation in a category of Abelian groups. In connection with elliptic curves over finite fields, the problem becomes the following: compute an isogeny (an algebraic homomorphism) between the elliptic curves given. The problem seems to be hard for solving with a quantum computer. ElGamal public-key encryption and Diffie-Hellman key agreement are proposed for an isogeny cryptosystem. The paper describes theoretical background and a publickey encryption technique, followed by security analysis and consideration of cryptosystem parameters selection. A demonstrative example of encryption is included as well. public-key cryptography, elliptic curve cryptosystem, cryptosystem on isogenies of elliptic curves, isogeny star, isogeny cycle, quantum computer
EMPLOYEE JOB INVOLVEMENT AND SENSE OF PARTICIPATION INFLUENCE ON JOB SATISFACTION: AN EMPIRICAL EVIDENCE

The present paper makes a humble academic effort to study the influence of job involvement and sense of participation on employees’ job satisfaction. The unit of study for the present analysis is a select private sector bank. The objective for this study is to explore the possible influence of the aforesaid parameters on job satisfaction. Three hypotheses have been framed and with the help of f-test verified. The statistical techniques like mean, standard deviation have been applied and t-test used to assess the mean difference. On the basis of statistical data thus generated certain inferences have been drawn. The study finally arrives at several conclusions and offers suggestions for policy implications of the bank. The present paper is duly supported by updated references to the context.
Clustering in free recall as a function of certain methodological variations.

Abstract : Three experiments involving category clustering in lists composed of high-frequency (HF) and low-frequency (LF) associates of the category names are reported. The major results were: 1. Block presentation augments clustering in both lists and augments word recall in HF but not in LF lists. 2. Word recall and clustering are higher in HF lists than in LF lists. 3. Duration of item presentation interval augments both clustering and word recall within limits. 4. An immediate recall augments or maintains clustering and word recall on a second recall, obtained after a short delay. 5. These findings and certain interactions are discussed with respect to the interpretation of recall of categorized lists. It is concluded that a coding hypothesis cannot do justice to all the findings. Associations between the category names and their instances or among the instances themselves are suggested as supplemental or alternative mechanisms. (Author)
Increased FDG bone marrow uptake after intracoronary progenitor cell therapy

Summary Patients with coronary artery disease who undergo FDG PET for therapy monitoring after intracoronary progenitor cell infusion (PCT) show an increased bone marrow up-take in some cases. Aim of the study was to evaluate the systemic bone marrow glucose metabolism in this patient group after PCT. Patients, methods: FDG bone marrow uptake (BMU), measured as standardized uptake value (SUVmax) in the thoracic spine, was retrospectively evaluated in 23 control patients who did not receive PCT and in 75 patients who received PCT 3 ± 2.2 days before PET scanning. Five out of them were pretreated with granulocyte colony-stimulating factor (G-CSF) 5 days prior to PCT and 10 ± 1.2 days before PET scanning. In 39 patients who received only PCT without G-CSF and underwent PET therapy monitoring 4 months later, baseline and follow up bone marrow uptake were measured. Leucocytes, C-reactive protein (CRP) levels and the influence of nicotine consumption were compared with the BMU. Results: In patients (n = 70) who received PCT without G-CSF, BMU median (1.3) was slightly, but significantly higher than in the controls (1.0) (p = 0.02) regardless nicotine consumption. BMU did not change significantly 4 months later (1.2) (p = 0.41, n.s.). After G-CSF pretreatment, patients showed a significantly higher bone marrow uptake (3.7) compared to patients only treated with PCT (1.3) (p = 0.023). Leucocyte blood levels were significantly higher in patients with a BMU ≥ 2.5 compared to patients with a bone marrow SUVmax < 2.5 (p <0.001). CRP values did not correlate with the BMU (rho -0.02, p = 0.38). Conclusion: Monitoring PCT patients, a slightly increased FDG BMU may be observed which remains unchanged for several months. Unspecific bone marrow reactions after PCT may be associated with increased leucocyte blood levels and play a role in the changed systemic glucose BMU.
QTc Monitoring During a Phase I Study: Experience With SR271425

Objective:SR271425 is a thioxanthone cytotoxic drug that induces dose-related cardiac electrophysiologic changes in preclinical models. A phase I trial was conducted to determine the maximally tolerated dose and safety profile, notably cardiac events. Methods:SR271425 was administered weekly as a 2-hour single intravenous infusion with a fixed 30 mg/m2 increment at each dose level (DL). A sustained cardiac evaluation was performed. ECG parameters were evaluated at bedside by an investigator or a cardiologist, as well as by central reading for dose limiting toxicity (DLT) determination. Results:Sixteen patients were treated. Five DLs were explored, from 75 mg/m2/wk to 195 mg/m2/wk. Fourteen patients (87.5%) experienced noncardiac adverse events related to treatment; only 2 patients presented grade 3 toxicity (nausea/vomiting and GGT increase) and no grade 4 toxicities were reported. Asymptomatic grade 1 or 2 QTcF prolongations were observed in 5 patients during central readings, and in 4 cases at bedside. One QTc-DLT, registered at bedside (grade 2), was unconfirmed at central reading, while another QTc-DLT, not noted at bedside, was highlighted by central reading. No arrhythmias or QRS prolongations were observed. Conclusions:The maximum tolerated dose of SR271425 was not reached in this trial due to early termination of the trial, not related to cardiac toxicity, following the termination of the development program by the sponsor. Sustained ECG monitoring is quite feasible in oncology phase I trials, but discrepancies between bedside and central evaluation could lead to conflicting decisions for management of patient care.
The development of cognitive maps of large- and small-scale spaces.

Kindergartners, second, and fifth graders made repeated trips through a large- or small-scale model town, and then constructed from memory the layout of buildings in either a large- or small-scale space. Accuracy of construction increased as a function of developmental level and repeated trips through the town. Children's constructions were most accurate when they were tested in the same-scale environment as that in which they developed their spatial knowledge; accuracy was impaired significantly only when children were exposed to a small space and then reconstructed in a large space. Results were interpreted in terms of a "competence-load trade-off. "