Miracle-dz/UniFAR-FTUs huggingface dataset:
Absorption, Tissue Distribution and Elimination of 4-[3H]-Epigallocatechin Gallate in Beagle Dogs

Polyphenols found in tea are potent antioxidants and have inhibitory activity against tumorigenicity. The purpose of the described study was to assess the absorption, tissue distribution, and elimination of epigallocatechin gallate (EGCG), the principal catechin found in green tea, in a nonrodent species. 4-[3H]-EGCG was administered to beagle dogs by intravenous (IV) and oral routes. Following IV administration of 25 mg/kg, radioactivity in the bloodstream resided predominantly in the plasma. Distribution occurred during the first hour, and the plasma levels of total radioactivity declined with a mean half-life of approximately 7 hours. The apparent volume of distribution (0.65 l/kg) indicated wide distribution, and the total body clearance (1.01 ml/min-kg) was low. A subsequent single oral dose (250 mg/kg) was rapidly absorbed, with peak plasma levels at about 1 hour after administration, followed by elimination with a mean half-life of 8.61 hours. The mean area under the curve (AUC) for total radioactivity was approximately 20% of the value following IV administration (corrected for dose administered). Excretion of radioactivity in the feces predominated over urinary excretion following both IV and oral administration of [3H]-EGCG. Tissue distribution was determined 1 hour after an IV dose (25 mg/kg) administered after 27 days of oral treatment with EGCG (250 mg/kg/day) to mimic chronic consumption of tea. Radioactivity was distributed to a variety of epithelial tissues; the highest concentrations were observed in the liver and gastrointestinal tract tissues. Repeat dose oral administration of EGCG resulted in significantly lower blood radioactivity compared to the concentration following a single dose. These results are generally in accord with previous studies in rodents and indicate that, after oral administration, EGCG (as parent compound and metabolites) is widely distributed to tissues where it can exert a chemopreventive effect.
Echinococcus granulosus: in vitro effect of monensin on the tegument of the protoscolex

SUMMARY Protoscoleces of Echinococcus granulosus were incubated in a 10 μm solution of monensin and their viability and the ultrastructure of their tegument were monitored over a 36 h period. The earliest effects of the lonophore, apparent within 15 min, involved a degree of cisternal swelling of the tegumentary Golgi complexes. Swelling became more pronounced with time and cytons eventually contained numerous large electron-lucent vesicles. Residual bodies indicative of autophagy were observed in the cytons and distal cytoplasm from 1 h onwards. All movement of protoscoleces ceased after 1 h and the surface of the soma subsequently became folded, possibly suggesting spastic paralysis. Later, vacuoles and large cytoplasmic blebs were observed in the distal cytoplasm and viability dropped rapidly after 12 h. All protoscoleces were dead at 36 h. The potential of monensin as an in vivo protoscolicidal agent is discussed.
Titanium/Polyetheretherketone Cages for Cervical Arthrodesis with Degenerative and Traumatic Pathologies: Early Clinical Outcomes and Fusion Rates

Anterior cervical discectomy and fusion is the most commonly employed surgical technique for treating cervical spondylosis. Although autologous bone grafts are considered the gold standard in achieving fusion, associated short‐ and long‐term morbidities have led to a search for alternative materials. These have included carbon‐fiber, titanium alloy (Ti) and ceramic and polyetheretherketone (PEEK) based implants. Recent attempts to optimize cage implants through using composite designs have combined Ti and PEEK. However, there are few published reports on the clinical and radiological outcomes of commercially available composite cages. Our study aimed to provide and evaluate initial outcomes of a composite Ti/PEEK cage.
Reproducibility of a commercially available subgingival plaque sampling strategy and analysis strategy with oligonucleotide probes

Abstract Objectives: The aim was to evaluate the intra-test agreement of pooled samples from the deepest periodontal pocket of each quadrant with a commercially available test kit based on hybridization of 16S rRNA. Material and methods: Plaque samples of 50 patients with generalized severe chronic periodontitis before therapy were pooled in two separate vials in order to detect and compare counts of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola. Cohen’s κ and interclass correlation coefficients were calculated to judge intra-test agreement. Results: Cohen’s κ for detection and counts of Tannerella forsythia and Treponema denticola showed a perfect agreement. Porphyromonas ginigivalis was identified in both tests with a substantial agreement, whereas detection of Aggregatibacter actinomycetemcomitans varied in eight patients resulting in a good agreement. Possible confounding factors could not be identified statistically. Conclusion: Test results of the commercial 16S rRNA test are perfectly reproducible regarding detection of red complex pathogens. Intra-test agreement concerning detection of Aggregatibacter actinomycetemcomitans was less favorable. Clinical relevance: Detection of certain periodontal pathogens may alter the treatment and lead to prescription of antibiotics parallel to mechanical debridement. It is quite important not to use antibiotics excessively. Thus, the basis for decision-making in favor of antibiotics should be solid.
Serum Uric Acid and the Renin‐Angiotensin System in Hypertension

To study whether the renin‐angiotensin system is related to hyperuricemia in hypertension, the serum concentration of uric acid was determined in 96 patients with various types of hypertension and various degrees of plasma renin activity (PRA). In malignant hypertension, both PRA and the serum uric acid level were higher than in essential hypertension; but in primary aldosteronism or desoxycorticosterone‐excess hypertension, they were lower than in the essential type. In renovascular hypertension, PRA was higher than in essential hypertension, but the serum uric acid levels were similar. There were no differences in PRA and serum uric acid concentration between Cushing's syndrome and essential hypertension. The serum uric acid level in high‐renin essential hypertension was higher than in either the normal‐renin or the low‐renin type. There was a significant correlation between serum uric acid concentration and PRA in the basal state, and between the change in PRA and the change in serum uric acid induced by administration of furosemide. Apparently the close correlation between the renin‐angiotensin system and the concentration of serum uric acid is related to changes in extracellular fluid volume, although an intrarenal effect of angiotensin II cannot be excluded.
Dependence of the cellular internalization and transfection efficiency on the structure and physicochemical properties of cationic detergent/DNA/liposomes

Control of the structure and physicochemical properties of DNA complexed with nonviral vectors is essential for efficient biodistribution and gene delivery to cells. Cationic liposomes interact with DNA giving transfection competent but large and heterogeneous aggregates. On the other hand, cationic detergents condense DNA into small homogeneous but reversible complexes inefficient for transfection.
Scalar transfer across the air-water turbulent interface

Mass transfer across the gas-water interface is important in many fields, but the present understanding of the scalar transport as mediated by the complex near-surface turbulence is still far from complete. In this work, an innovative PIV based measurement method was employed to investigate the near surface turbulence. Turbulence measurement with respect to the fluctuating interface was performed and the gradient of the vertical fluctuating velocity (Hanratty’s β) deemed as a critical controlling parameter was quantified. Several distinctly different but typical flow conditions were investigated and the associated mass transfer coefficient was measured. Based on these experimental works, an empirical relation, very similar to the earlier Law and Khoo’s , relating the mass transport across the turbulent interface to the turbulence parameterβ was determined in the midst of vastly different flow conditions where turbulence is induced simultaneously from above and beneath the gas-water interface. Topical heading: Fluid mechanics and transport phenomena
Extratropical Influence on ITCZ Shifts in Slab Ocean Simulations of Global Warming

AbstractRecent studies with climate models have demonstrated the power of extratropical forcing in causing the intertropical convergence zone (ITCZ) to shift northward or southward, and paleoclimate data support the notion that there have been large shifts in the ITCZ over time. It is shown that similar notions apply to slab ocean simulations of global warming. Nine slab ocean model simulations from different modeling centers show a wide range of ITCZ shifts in response to doubling carbon dioxide concentrations, which are experienced in a rather zonally symmetric way in the tropics. Using an attribution strategy based on fundamental energetic constraints, it is shown that responses of clouds and ice in the extratropics explain much of the range of ITCZ responses. There are also some positive feedbacks within the tropics due to increasing water vapor content and high clouds in the new ITCZ location, which amplify the changes driven from the extratropics. This study shows the clear importance of simulating .
Association between PD-L1 and HPV status and the prognostic value for HPV treatment in premalignant cervical lesion patients

Abstract The difference of PD-L1 expression between only HPV-positive patients and premalignant cervical lesion patients did not be reported in present studies. And to test the PD-L1 expression in some cervical cell lesion studies using cervical exfoliated cells sample also was ignored. Meanwhile, the PD-L1 expression as a predictive biomarker still existed controversy. So in the study, first to compare the expression of PD-L1 between only HPV-positive patients and premalignant cervical lesion patients, then to research the association between PD-L1 and HPV status, lastly to explore the possible prognostic value for HPV treatment in premalignant cervical lesion patients. Cervical exfoliated cells samples of 54 premalignant cervical lesion patients with HPV16 infection were collected; meanwhile the cervical exfoliated cells samples from 20 healthy women without HPV infection and 20 patients with only HPV16 infection but cervical cytology normal were collected as 2 control groups. Flow-through hybridization and gene chip (FHGC) was used to detect the HPV type, the PD-L1 expression was tested by Flow cytometry analysis, the methylation-sensitive high-resolution melting (MS-HRM) was used to test the HPV16 L1 gene methylation. The 54 premalignant cervical lesion patients were followed up in 18 months to assess the prognostic value of PD-L1 for HPV treatment. The PD-L1 positive cell rate and mean fluorescence intensity of PD-L1 positive cell in premalignant cervical lesion patients with HPV16 infection were higher than 2 control groups. Mean fluorescence intensity of PD-L1 positive cell were increased in 54 cases when existing multiple HPV status and high HPV16-L1 gene methylation (L1 gene methylation more than 50%). High PD-L1 expression (PD-L1 positive cell rate more than 10%), high HPV16-L1 gene methylation, and multiple HPV infection status could prolong the time to clean HPV infection by Kaplan–Meier analysis. Multivariate Cox proportional hazards analysis also showed that all of high PD-L1 expression, high HPV-L1 methylation, and multiple HPV infection status should increase the risk of HPV unclearance in premalignant cervical lesion patients; the hazard ratio (HR) was 2.043 (CI: 1.050–3.973), 2.797 (CI: 1.277–6.122), and 3.050 (CI: 1.406–6.615). PD-L1 expression only was correction with HPV infection when the infection induced the cervical cells to create the lesion. PD-L1 was the risk factor of HPV unclearance in premalignant cervical lesion patients, so anti-PD-L1 therapy could be a potential effectiveness way of HPV infection in premalignant cervical lesion patients.
A comparison of the mini mental state exam to the montreal cognitive assessment in identifying cognitive deficits in Parkinson's disease

Dementia is an important and increasingly recognized problem in Parkinson's disease (PD). The mini‐mental state examination (MMSE) often fails to detect early cognitive decline. The Montreal cognitive assessment (MoCA) is a brief tool developed to detect mild cognitive impairment that assesses a broader range of domains frequently affected in PD. The scores on the MMSE and the MoCA were compared in 88 patients with PD. A pronounced ceiling effect was observed with the MMSE but not with the MoCA. The range and standard deviation of scores was larger with the MoCA(7–30, 4.26) than with the MMSE(16–30, 2.55). The percentage of subjects scoring below a cutoff of 26/30 (used by others to detect mild cognitive impairment) was higher on the MoCA (32%) than on the MMSE (11%)(P < 0.000002). Compared to the MMSE, the MoCA may be a more sensitive tool to identify early cognitive impairment in PD. © 2007 Movement Disorder Society
Nuclear factor one B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma

Glioblastoma (GBM) is an essentially incurable and rapidly fatal cancer, with few markers predicting a favourable prognosis. Here we report that the transcription factor NFIB is associated with significantly improved survival in GBM. NFIB expression correlates inversely with astrocytoma grade and is lowest in mesenchymal GBM. Ectopic expression of NFIB in low-passage, patient-derived classical and mesenchymal subtype GBM cells inhibits tumourigenesis. Ectopic NFIB expression activated phospho-STAT3 signalling only in classical and mesenchymal GBM cells, suggesting a mechanism through which NFIB may exert its context-dependent tumour suppressor activity. Finally, NFIB expression can be induced in GBM cells by drug treatment with beneficial effects.
CORPORATE GOVERNANCE COMPLIANCE AND THE EFFECTS TO CAPITAL STRUCTURE IN MALAYSIA

This study attempts to investigate the compliance level among public listed companies with the implementation of corporate governance code of best practices and the association to firm’s capital structure in Malaysia. The data are gathered from the analysis of companies’ annual report and Thompson DataStream for a sample of 126 companies over a period of 1998 to 2006. The study employs multiple regression analyses on board of director’s facets such dual leadership, board size and board meeting. The preliminary results of this study reveal most of the company has complied well with the code and there is a significant association to the firm’s capital structure.
Sinus floor elevation using osteotomes: a systematic review and meta-analysis.

BACKGROUND Various techniques of sinus floor elevation (SFE) are described. The elevation with osteotomes (OSFE) from a crestal approach is a relatively new technique. The aim of this systematic review and meta-analysis was to evaluate the clinical outcome of implants placed into the maxillary sinus augmented with an OSFE technique. METHODS A systematic online and manual review of the literature identified articles dealing with OSFE. Applying rigid inclusion criteria, screening and data abstraction were performed independently by two reviewers. The follow-up of loaded implants was a minimum of 6 months. The identified articles were analyzed regarding implant outcome and defined surgical aspects. Survival and success rates were estimated by Kaplan-Meier curves. RESULTS Eight out of 44 articles dealing with osteotome sinus floor elevation met the inclusion criteria. Five of the studies met established success criteria. The survival and success rates were 95.7% and 96.0% after 24 months and 36 months, respectively. The median and mean follow-up periods were 24 and 18.73 months for the survival rate and 24 and 19.7 months for the success rate. Regarding different surgical elements, i.e., osteotome techniques, implant types, and augmentation materials, the database was multivariate. Thus, no statistical analysis could be performed on these parameters. CONCLUSIONS Short-term clinical success/survival (<or years) of implants placed with an osteotome sinus floor elevation technique seems to be similar to that of implants conventionally placed in the partially edentulous maxilla. Controlled prospective clinical studies are needed to evaluate the long-term outcome and various surgical modifications of OSFE.
Resource translocation drives δ13C fractionation during recovery from disturbance in giant kelp, Macrocystis pyrifera

Resource allocation and translocation are fundamental physiological functions for autotrophs. The mobilization and use of resources drive population dynamics by regulating growth and recovery of individuals, but also influences ecosystem‐level processes such as primary productivity and carbon cycling. This study provides the first observation of translocation‐driven gradients of δ13C in macroalgae, a critically important phenomenon recognized in vascular plants for decades. A ~10‰ δ13C increase in new giant kelp (Macrocystis pyrifera) fronds relative to mature canopy blades was produced after 5 weeks following a biomass removal experiment, more than twice the variation typical for macroalgae. The observed δ13C patterns are consistent with tissue enrichment following resource translocation in vascular plants. The analogous source‐sink relationships and consistent translocation patterns in Macrocystis and vascular plants suggest that translocation of stored resources is critical for structuring productivity and recovery from disturbance in important, habitat‐forming macroalgae such as kelps and fucoids.
Development, Survivorship, and Reproduction of Helicoverpa armigera (Lepidoptera: Noctuidae) Under Constant and Alternating Temperatures

Abstract Laboratory studies were conducted to assess the effect of temperature on the survival, development, fecundity, and longevity of Helicoverpa armigera (Hübner) at 11 constant temperatures ranging from 12.5 to 40°C, as well as at five alternating temperature regimes (25–10, 30–15, 32.5–17.5, 35–20, and 35–27.5°C) and under a photoperiod of 16:8 (L:D) h. H. armigera reared at constant temperatures did not develop from egg to adult (emergence) outside the temperature range of 17.5–32.5°C. The alternating conditions expanded this range from 10 to 35°C. The lowest developmental thresholds of the immature stages were estimated by a linear model and ranged from 10.17 (pupal stage) to 11.95°C (egg stage) at constant temperature regimes and from 1.1 to 5.5°C, respectively at alternating temperatures. The values of developmental thresholds estimated using the nonlinear (Lactin-2) model were lower than those estimated by the linear model for constant and alternating temperature regimes except for larval and pupal stages at constant temperatures. Mean adult longevity fluctuated from 34.4 d at 15°C to 7.6 d at 35°C. Females reared under all alternating temperature regimes laid more eggs than females reared at any, except the 25°C, constant temperature treatment. The intrinsic rate of increase was highest at 27.5°C, at both the constant and the corresponding alternating temperature regimes (0.147 and 0.139, respectively). Extreme temperatures had a negative effect on life table parameters.
Electromagnetic Gyroscopic Motion

A problem of the gyroscopic motions around a fixed point, under the action of a gyrostatic moment vector, in presence of electromagnetic field and Newtonian one, is considered. The small parameter technique is used to investigate the periodic solutions for the derived equations of such motion problem. A geometric interpretation of motion will be given in terms of Euler’s angles (). Computer programs are carried out to integrate the attained quasilinear autonomous system using a fourth-order Runge-Kutta method. A comparison between the obtained analytical solutions and the numerical ones is investigated to calculate the errors between them.
Application of the Continuous Glucose Monitoring System (CGMS) in the 72-hour fast test in two patients with hypoglycemia.

OBJECTIVE Hypoglycemia occurs in several pathologic states, and the supervised 72-h fast is the classic diagnostic test for hypoglycemia caused by insulinoma. The Continuous Glucose Monitoring System (CGMS), Medtronic MiniMed, Northridge, CA) is an appropriate method to detect asymptomatic hypoglycemia episodes in diabetes mellitus patients. In the present study, we use the CGMS to monitor glucose dynamics during a 72-h fast. METHODS Two patients with hypoglycemia disorders were admitted to the hospital for testing. The CGMS sensors were inserted into the subcutaneous tissue prior to starting a 72-h fast test. Finger stick glucose levels were taken every 3-4 h, and the data were entered into the monitor for calibration. RESULTS Paired glucose readings from CGMS and conventional meters were correlated significantly (P < 0.001, r2 = 0.79). There was no significant difference between the CGMS glucose levels and conventional meter glucose levels (P > 0.05). Use of CGMS detected a high prevalence of asymptomatic hypoglycemia and two types of hypoglycemia dynamics during a 72-h fast test. CONCLUSIONS This initial report using CGMS detected two types of hypoglycemia dynamics during 72-h fasting, which may provide clues to better understand the pathophysiology of hypoglycemia.
HUMAN COCCIDIOIDOMYCOSIS

Coccidioidomycosis as a respiratory infection will be considered first with respect to its "biological gradient" or "infection spectrum. " Then its epidemiology will be reviewed in the pattern of factors of the etiological agent, Coccidioides immitis, of host effects in man, and of the environmental factors which affect these interrelationships. Finally, we shall assess plausible means which its epidemiology indicates for meeting this problem. Basic to this entire consideration is Karl Meyer's (40) fundamental observation that C. immitis is a "pathogenic saprophyte. " Thus, although we shall refer to man as the host, in reality he is not a part of an infection chain. Whereas our interest centers on man and ultimately we shall have to focus on long-range protection for him, this merely will have the effect of minimizing the "pathogenic" component of "pathogenic saprophyte. "