Miracle-dz/UniFAR-FTUs huggingface dataset:
Health Information Privacy and Security Framework: Supporting Electronic Medical Records in Healthcare Systems

The need to record information regarding a patient has been considered as an old, but important issue within the medical arena. Recently, much progress has been noted in the process of collection, storage, and retrieval of patients‘ data, with more healthcare organizations moving towards paperless environment of electronic medical records (EMRs). However, only a handful of studies have looked into privacy and security issues associated with EMRs, as perceived by patients and healthcare providers. Such issues, if left unaddressed, may affect the quality of EMRs, the speed at which they are implemented and accepted by patients and providers, the ability for healthcare institutions to exchange patient information, as well as the quality of patient care and patient safety. As such, this article proposes a comprehensive and multidimensional framework of EMRs success in the healthcare sector. The framework developed in this study can be applied to evaluate and to measure the effectiveness of such EMRs.
Ginseng as a Potential Novel Addition to the Antikeloid Weaponry

Keloid scars are large protruding claw‐shaped lesions that develop beyond the confines of the wound and uniquely appears only in humans. For thousands of years ginseng has been used in the traditional medicine in oriental countries. It occupies a prominent position in the list of the best‐selling medicinal herbs in the world. Panax ginseng often called Asian or Korean ginseng, is the most extensively used and the best grade of ginseng and the term of ‘ginseng’ generally refers to Panax ginseng. Previous studies have revealed that ginseng inhibits NF‐kappa B, TGF‐β, IL‐6, ACE and MMP‐2 and these factors play a pivotal role in keloid formation pathogenesis. Therefore it could be reasoned that ginseng could be effective for the treatment of the keloid scars. Clinical studies by topical applications of iPanax notoginseng (800 µg/ml) are warranted. Copyright © 2012 John Wiley & Sons, Ltd.
Non-ablative 1540 fractional laser: How far could it help injection lipolysis and dermal fillers in lower-face rejuvenation? a randomized controlled trial

Abstract Background: Rejuvenation of the lower face can be challenging and no single modality can accomplish all its complex events. Patients and methods: This 18-month study included 24 female patients with a primary complaint of lower-face aging signs. They were randomly allocated to either Group A, who received injection lipolysis and hyaluronic acid dermal filler, or Group B who in addition received non-ablative 1540 fractional laser. The improvement evaluation score used was the global aesthetic improvement scale (GAIS). Patient's satisfaction level was also recorded. Both were repeated at Months 6, 13 and 18. Results: At all evaluations, laser group showed higher degree of improvement. Interestingly, at short-term evaluation (6 month), there was no significant difference between both groups (P > 0.05). However, the laser group improvement in comparison to the other group became significant in the long-term evaluations (13 and 18 months) (P < 0.05). Conclusion: This study further documents the importance of combination therapy in facial rejuvenation, offering a treatment protocol combining injection lipolysis and hyaluronic acid as an effective, safe, short-term therapeutic option in lower-face rejuvenation. The addition of 1540 non-ablative fractional laser to the protocol offers a higher efficacy with longer-term effects and no adverse events.
Transient State Finite Element Model to Analyse Thermal Variations in Peripheral Region of Human Limb undergoing Healing after Surgery

The temperature distribution in human tissues is significantly affected by the introduction of an abnormality. The study of temperature distribution in different layers of peripheral tissue is intended to contribute in the diagnosis of many disorders in various organs. In this paper, an axisymmetric one dimensional model has been developed to study transient state temperature distribution in different layers of normal and post surgery peripheral (abnormal) tissues of human limb. Taking into account the variable physiological parameters in dermal layer of peripheral region, the well known Pennes' bio heat equation is used to analyse and compare the time-dependent temperature distribution of normal and abnormal tissues using finite element technique. A computer program in MATLAB has been developed to simulate the results.
The utility of the records medical: factors associated with the medication errors in chronic disease

ABSTRACT Objective: This study describes the development of the medication history of the medical records to measure factors associated with medication errors among chronic diseases patients in Diamantina, Minas Gerais. Methods: retrospective, descriptive observational study of secondary data, through the review of medical records of hypertensive and diabetic patients, from March to October 2016. Results: The patients the mean age of patient was 62.1 ± 14.3 years. The number of basic nursing care (95.5%) prevailed and physician consultations were 82.6%. Polypharmacy was recorded in 54% of sample, and review of the medication lists by a pharmacist revealed that 67.0% drug included at least one risk. The most common risks were: drug-drug interaction (57.8%), renal risk (29.8%), risk of falling (12.9%) and duplicate therapies (11.9%). Factors associated with medications errors history were chronic diseases and polypharmacy, that persisted in multivariate analysis, with adjusted RP chronic diseases, diabetes RP 1.55 (95%IC 1.04-1.94), diabetes/hypertension RP 1.6 (95%CI 1.09-1.23) and polypharmacy RP 1.61 (95%IC 1.41-1.85), respectively. Conclusion: Medication errors are known to compromise patient safety. This has led to the suggestion that medication reconciliation an entry point into the systems health, ongoing care coordination and a person focused approach for people and their families.
Tracking of Gross Motor Coordination From Childhood Into Adolescence

Purpose: The purpose of this study was to analyze tracking and stability of motor coordination in children from age 6 years to ages 9 and 13 years. Method: Data were from the Copenhagen School Child Intervention Study. Motor coordination (MC) was measured using the körperkoordinationstest für Kinder (KTK) test. The crude performance score on every item was converted into a standardized “score” based on the original German reference study, which was used to generate a total standardized motor coordination (MQ) score. The MQ scores, which represented children's level of gross MC, were classified as low (MQ score < 85), normal (MQ score = 85–115), or high (MQ score>115). Pearson correlation was used to calculate the tracking coefficients of each KTK element and MQ score, and weighted kappa was used to analyze maintenance in MC classification groups. Mixed-effects logistic regression analyses were performed to examine the odds of remaining in the low MC group over time based on body mass index (BMI), weight, and height tertiles. Results: Tracking coefficients among the MQ score and each KTK element at different ages were moderate (r>.35). Children in the highest BMI and weight tertiles had a 5.44 and 5.15 times greater chance to be in the lower MC classification group during the 7-year follow-up, respectively, in comparison with children in their lowest tertiles. Conclusion: MC tracked moderately through childhood to early adolescence. Because heavier children had a greater chance to be in the lower MC group at older ages, intervention may be useful at earlier ages for those with lower MC and disadvantageous weight status.
Abnormal iron uptake and liver cancer

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Iron overload represents a significant risk factor in the development of HCC. Hereditary hemochromatosis (HH) is a genetic iron overload disease characterized by hepatic iron accumulation. The potential link between these two conditions leads to significant curiosity about regulation of iron homeostasis. Importantly, one of the HH genes, HAMP, encodes the master regulator of iron homeostasis, hepcidin, which is expressed by hepatocytes. Recent studies have shown that the remaining HH genes are either upstream regulators (HFE, HFE2, and TFR2) or downstream targets (FPN) of hepcidin. Moreover, the presence of additional signaling pathways in the liver that contribute to regulation of hepcidin expression has been documented. The function of these iron-regulatory proteins is currently being investigated to determine if they play a role in abnormal iron uptake in tumors. This review summarizes these recent studies and briefly discusses new directions in the treatment of iron overload in HCC patients.
Gender Differences in Criminal Sentencing: Do Effects Vary Across Violent, Property, and Drug Offenses?

Many studies find that females benefit from their gender in sentencing decisions. Few researchers, however, address whether the gender-sentencing association might be stronger for some crimes, such as minor nonviolent offending, and weaker for other offenses, such as serious violent crime. Copyright (c) 2006 by the Southwestern Social Science Association.
The Type III Toxins of Pseudomonas aeruginosa Disrupt Epithelial Barrier Function

ABSTRACT The type III secreted toxins of Pseudomonas aeruginosa are important virulence factors associated with clinically important infection. However, their effects on bacterial invasion across mucosal surfaces have not been well characterized. One of the most commonly expressed toxins, ExoS, has two domains that are predicted to affect cytoskeletal integrity, including a GTPase-activating protein (GAP) domain, which targets Rho, a major regulator of actin polymerization; and an ADP-ribosylating domain that affects the ERM proteins, which link the plasma membrane to the actin cytoskeleton. The activities of these toxins, and ExoS specifically, on the permeability properties of polarized airway epithelial cells with intact tight junctions were examined. Strains expressing type III toxins altered the distribution of the tight junction proteins ZO-1 and occludin and were able to transmigrate across polarized airway epithelial monolayers, in contrast to ΔSTY mutants. These effects on epithelial permeability were associated with the ADP-ribosylating domain of ExoS, as bacteria expressing plasmids lacking expression of the ExoS GAP activity nonetheless increased the permeation of fluorescent dextrans, as well as bacteria, across polarized airway epithelial cells. Treatment of epithelial cells with cytochalasin D depolymerized actin filaments and increased permeation across the monolayers but did not eliminate the differential effects of wild-type and toxin-negative mutants on the epithelial cells, suggesting that additional epithelial targets are involved. Confocal imaging studies demonstrated that ZO-1, occludin, and ezrin undergo substantial redistribution in human airway cells intoxicated by ExoS, -T, and -Y. These studies support the hypothesis that type III toxins enhance P. aeruginosa's invasive capabilities by interacting with multiple eukaryotic cytoskeletal components.
Effects of Short-Term Environment Change on Language Attrition : Cross-Linguistic Case Studies

In this study, language attrition is examined from the perspective of both first and second language. Using the bilingual language mode continuum model proposed by Grosjean (2001) and further developed by Schmid (2007), an interview-based study was designed to track shifts in linguistic performance both before and after a change in linguistic environment. This change was from an L2-dominant environment to an L1dominant environment, and was "short-term" because it lasted for a period of days, rather than a period of years as in previous attrition studies. The study included a story-telling task, a phonetically-prompted vocabulary listing task, and a semantically-prompted vocabulary listing task. All three tasks were performed in both of each speaker's languages in each of two interviews: one before and one after the change in environment. The subjects included one native speaker each ofMandarin Chinese, Cantonese Chinese, and Korean. All spoke English as a second language. The study found that a shift in language mode could be detected over this short-term timeframe, and that this shift left a measurable effect (improvement in L1, decline in L2, in accordance with the continuum theory) for at least several days after the subjects returned to the L2-dominant environment.
Building the Learning Organization: Achieving Strategic Advantage through a Commitment to Learning

From technology and globalization to the increasing power of customers, the forces that have created the seismic changes in business today also serve as the foundation for the next generation of learning organizations. With lessons forged by such world-class leaders as Nokia, Alcoa and Canadian Imperial Bank, Michael Marquardt explains how to improve performance and transform an organization into one that continues to flourish with knowledge. In this new edition of his award-winning book, Marquardt advises how to harness the collective genius of people within an organization to perpetuate the power of the learning organization. He also added dozens of case studies to demonstrate the applicability of his Systems Learning Organization model and to illustrate how each of the five subsystems - learning, organization, people, knowledge and technology - synergize.
Death effector activation in the subventricular zone subsequent to perinatal hypoxia/ischemia

Perinatal hypoxia/ischemia (H/I) is the leading cause of neurological injury resulting from birth complications and pre‐maturity. Our studies have demonstrated that this injury depletes the subventricular zone (SVZ) of progenitors. In this study, we sought to reveal which cell death pathways are activated within these progenitors after H/I. We found that calpain activity is detected as early as 4 h of reperfusion and is sustained for 48 h, while caspase 3 activation does not occur until 8 h and peaks at 24 h post‐insult. Activated calpains and caspase 3 co‐localized within precursors situated in the lateral aspects of the SVZ (which coincides with progenitor cell death), whereas neither enzyme was activated in the medial SVZ (which harbors the neural stem cells that are resilient to this insult). These studies reveal targets for neuroprotective agents to protect precursors from cell death towards the goal of restoring normal brain development after H/I.
Raloxifene Reverses Bone Loss in Postmenopausal Women with Mild Asymptomatic Primary Hyperparathyroidism

RALOXIFENE IS a selective estrogen receptor modulator (SERM) acting as a tissue-specific estrogen receptor agonist on bone and lipid metabolism and as an estrogen antagonist in the breast and uterus, currently approved for both prevention and treatment of postmenopausal osteoporosis in the United States and Europe. It has been shown to reduce the incidence of vertebral fractures (1) and of breast cancer (1) in osteoporotic women. Here, we report the effects of 12 months of treatment with raloxifene, 60 mg/day or 120 mg/day, on lumbar spine and femur neck bone mineral density (BMD) and biochemical parameters in 3 postmenopausal osteopenic women (mean age, 64; range 59–67 years; mean lumbar spine T score, 21.92) with mild, asymptomatic primary hyperparathyroidism. Patients were experiencing rapid bone loss during the last 2 years (Fig. 1). Treatment with raloxifene was considered because they refused either parathyroid surgery or hormone replacement therapy. Options and treatment characteristics were discussed with the patients and they gave their consent to treatment. BMD increased by 3.4% at lumbar spine and by 2.5% at femur neck after 12 months of treatment (Fig. 1). The effects of treatment on biochemical parameters are shown in Table 1. Total calcium and phosphate levels decreased in all the patients after 12 months of treatment. On the other hand, ionized calcium and intact parathyroid hormone (iPTH) levels showed a decrease after 6 months of treatment, but returned close to baseline values at month 12. Deoxypyridinoline excretion, a specific marker of bone resorption, decreased by 33% after 6 months and by 61% after 12 months; fasting calcium excretion was 39% lower at 6 months and 56% lower at 12 months. Serum total alkaline phosphatase, a marker of osteoblast function, showed only a slight decrease. The apparently different effects of raloxifene on serum total and ionized calcium levels found in our patients also has been noted with hormone replacement therapy in both postmenopausal women with mild primary hyperparathyroidism and normal, early postmenopausal women. (3)
Cortical connections of the somatosensory fields of the lateral sulcus of macaques: Evidence for a corticolimbic pathway for touch

The ipsilateral corticocortical connections of the somatosensory fields of the lateral sulcus of macaques were examined with both anterograde and retrograde axonal transport methods. In most cases, the field of interest was identified prior to the injection of the tracer substance by recording neuronal responses to somatic stimulation.
Banded Intracochlear Electrode Array: Evaluation of Insertion Trauma in Human Temporal Bones

A banded free-fit scala tympani array was inserted into the basal turn of nine human cochleas to evaluate the trauma produced by the procedure. These nine cochleas, together with five nonimplanted controls, were serially sectioned and examined microscopically for damage to the membranous labyrinth, in particular the spiral ligament, the basilar and Reissner's membranes, the stria vascularis, and the osseous spiral lamina. The severity and location of any trauma along the cochlear spiral were recorded. The results indicate that the insertion of the banded scala tympani array resulted in minimal mechanical damage, occurring primarily to a localized region of the spiral ligament. This would not result in significant neural degeneration, and therefore would not compromise the efficacy of the multichannel cochlear prosthesis.
Impression Formation and Durability in Mediated Communication

Using literature from impression formation and social information processing theory, we examine the impact of communication style on impression formation and durability in a mediated environment. We leverage common writing styles found in workplace emails—emoticons, uppercase, lowercase, typographical errors—to examine how message receivers evaluate senders using these styles. Via a lab experiment with 748 subjects, including undergraduate students, graduate students, and working professionals, we found that impressions were associated with writing style beyond the email content. Receivers perceived senders of emails containing emoticons, errors, or written entirely in uppercase or lowercase as less functionally competent. They also perceived senders as less methodologically competent when emails used emoticons and less politically competent when emails were all lowercase or contained errors. They perceived senders using a neutral writing style as less sociable than senders using emoticons. In contrast to impression durability in face-to-face environments, receivers positively revised impressions when senders changed their style to neutral from any of the non-neutral styles. We attribute this difference to two characteristics of the IT artifact: symbol variety and reprocessability.
Generalized Common Informations: Measuring Commonness by the Conditional Maximal Correlation

In literature, different common informations were defined by G\'acs and K\"orner, by Wyner, and by Kumar, Li, and Gamal, respectively. In this paper, we define two generalized versions of common informations, named approximate and exact information-correlation functions, by exploiting the conditional maximal correlation as a commonness or privacy measure. These two generalized common informations encompass the notions of G\'acs-K\"orner's, Wyner's, and Kumar-Li-Gamal's common informations as special cases. Furthermore, to give operational characterizations of these two generalized common informations, we also study the problems of private sources synthesis and common information extraction, and show that the information-correlation functions are equal to the minimum rates of commonness needed to ensure that some conditional maximal correlation constraints are satisfied for the centralized setting versions of these problems. As a byproduct, the conditional maximal correlation has been studied as well.
Expression and analysis of a cytolethal distending toxin (cdt) gene operon in Campylobacter lari

Abstract The present study examines the expression of cytolethal distending toxin (cdt) gene encoding a cytotoxin in Campylobacter lari (n=6 urease-negative [UN] C. lari; n=4 urease-positive thermophilic Campylobacter [UPTC]). When reverse transcription polymerase chain reaction (RT-PCR) was carried out with 10 C. lari isolates using a primer pair to amplify the cdtB gene transcript segment, an approximate 260 bp RT-PCR amplicon was generated with all the isolates. In addition, cdtA, cdtB and cdtC gene operon was identified to be polycistronicly transcribed in the C. lari cells. The cdtB gene translation in the C. lari cells was also confirmed by Western blot analysis. Thus, the cdt gene operon in C. lari organisms, including UN C. lari and UPTC, was expressed at the transcriptional and translational levels in the cells. The present results suggest that all three cdt genes may be functional in the cells.