Miracle-dz/UniFAR-FTUs huggingface dataset:
Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells in vitro and in vivo, and increases chemosensitivity to 5-fluorouracil and gemcitabine

Pancreatic cancer (PC) is a common malignancy with a poorly understood pathogenesis. Currently, the efficacy of anti-PC therapies is insufficient, partially due to the chemoresistance of cancer cells. The present study aimed to elucidate the role of miR-183 in the proliferation, apoptosis, and chemosensitivity to 5-fluorouracil and gemcitabine of human PC cells and the associated mechanisms. PANC-1 cells were transfected with microRNA (miR)-183 inhibitors, and the effect of miR-183 on cell proliferation was evaluated via MTT assay. Apoptosis and cell cycle distribution were determined by flow cytometry. In vivo tumor xenograft models of PANC-1 cells were generated in BALB/c nude mice to examine the effect of miR-183 downregulation on tumor growth. Furthermore, components of the phosphatase and tensin homolog deleted on chromosome ten (PTEN)/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway were examined via reverse transcription-quantitative polymerase chain reaction and western blotting in the collected cells. Finally, PANC-1 cells were treated with 5-fluorouracil or gemcitabine and transfected with miR-183 inhibitors, and the viability of cells was determined by MTT assay. The results demonstrated that knockdown of miR-183 could significantly decrease proliferation and promote apoptosis of PANC-1 cells. The cells transfected with miR-183 inhibitors were significantly arrested at the G1 phase (P<0.01). Furthermore, miR-183 downregulation led to significant decreases in the mRNA levels of PI3K, Akt and B cell lymphoma-2 (Bcl-2) expression (P<0.001), and significant increases in PTEN and Bcl-2 associated X protein expression in PANC-1 cells (P<0.001). Knockdown of miR-183 was able to significantly increase the chemosensitivity of PANC-1 cells to 5-fluorouracil and gemcitabine. These results indicate that downregulation of miR-183 can inhibit the growth of PC cells in vitro and in vivo, and increase cell sensitivity to 5-fluorouracil and gemcitabine through regulating the PTEN/PI3K/Akt signaling pathway.
Sparse Coding Using the Locally Competitive Algorithm on the TrueNorth Neurosynaptic System

The Locally Competitive Algorithm (LCA) is a biologically plausible computational architecture for sparse coding, where a signal is represented as a linear combination of elements from an over-complete dictionary. In this paper we map the LCA algorithm on the brain-inspired, IBM TrueNorth Neurosynaptic System. We discuss data structures and representation as well as the architecture of functional processing units that perform non-linear threshold, vector-matrix multiplication. We also present the design of the micro-architectural units that facilitate the implementation of dynamical based iterative algorithms. Experimental results with the LCA algorithm using the limited precision, fixed-point arithmetic on TrueNorth compare favorably with results using floating-point computations on a general purpose computer. The scaling of the LCA algorithm within the constraints of the TrueNorth is also discussed.
Une logique d'exposition populaire : les images de la muséographie analogique

La designacion habitual de «dioramas» comprende, si analizamos, una gama de dispositivos museograficos que tienen una caracteristica en comun, la de instalar en la exposicion unas imagenes que se refieron a la realidad. Con este concepto se pueder calificar tales practicas de «museografia analogica» y describir sus principales dispositivos — el panorama, el diorama propriamente dicho, el grupo de animales, el interior de casa de epoca, el paisaje urbano y el ecosistema. El estudio de esas museografias analogicas lleva a imaginar como se autono- miza la presentacion en exposicion con relacion al orden de las colecciones y a su estudio. Se presenta una tipologia que esablece una diferencia entre unas exposiciones con logica exogena — cognitivas o situacionales — y unas exposiciones con logica endogena — tematicas, narrativas o demostra- tivas. Las museografias analogicas se situan en la dinamica de democratizacion que quiere abrir el museo a todos los publicos y a todos los territorios.
CHINET 2012 surveillance of antibiotic resistance in Acinetobacter baumannii isolates in China

Objective To investigate the antimicrobial resistance in the Acinetobacter baumannii strains in different parts of China during 2012.Methods A total of 8 739 clinical isolates of Acinetobacter were collected from 13 general hospitals and two children's hospitals,of which most were A.baumannii(89.6%,7 827/8 739). Antimicrobial susceptibility testing was carried out by means of KirbyBauer method according to the unified protocol.The susceptibility testing data were analyzed by WHONET5.6293 software according to CLSI 2013 breakpoints.Results Majority(85.4%)of the Acinetobacter strains were isolated from inpatients.The remaining 14.6% were from outpatients and emergency room patients.Of the 7 827 strains of A.baumannii,10.9%,35.2%,35.7% and 43.4% were resistant to tigecycline,minocycline,cefoperazone-sulbactam and amikacin,respectively.The percentage of A.baumannii resistant to imipenem and meropenem was 63.5% and 68.2%,respectively.The antimicrobial resistant pattern varied in different hospitals.The resistance of A.baumannii varied between different clinical departments.A number of pandrug resistant(PDR)(20.0%,1 567/7 827)and multidrug-resistant(MDR)(45.0%,3 521/7 827)A.baumannii were identified.Conclusions A.baumannii is the most popular pathogenic bacteria among Acinetobacter.The antibiotic resistance of A.baumannii is still increasing.Cefoperazone-sulbactam and minocycline has good in vitro antibacterial activity against A.baumannii. The antibiotic resistance of A.baumannii varies greatly with hospital and department.
An Empirical Analysis of W&R Based on Listed Companies' Investments in Vocational Education

W&R, an expert system of securities trading software, is tested through statistical and empirical analyses based on true data about vocational education on securities that are publicly available. With annual net profit margin, rate of return and win as management objectives. The non-directional W&R indicators are empirically analyzed based on theories of mathematical statistics. At last, annual rate of return and net profit margin of the W&R are determined to be 61.62 and 61.63% of Shanghai Stock Exchange indexes. Investment solutions with a win rate of 59.72% and an annual rate of return that is 6.6 times as high as annual interest rate of bank deposits are optional for those investors who are crazy about seeking high profits and willing to undertake risks.
Clinical profile of lung cancer in rural medical college of Maharashtra (India): a prospective study of three years

Aim: To Study the clinical, radiological & histological profile of lung cancer. Meterial & Methods: 94 patients who presented with cough, haemoptysis, chest pain, breathelessness, and having radiological features consistant with bronchogenic carcinoma subjected to sputum cytology, bronchoscopy, CT thorax & FNAB depending on need. Results : Highest incidence of lung malignancy was found in age group of 51-70 years (35.10%). Male :female ratio was 3:1. 54(57.44%) were smokers & 40 (42.55%) were non-smokers. Cough (88.33%), breathelesness (85%) and chest pain (48.33%) were the commonest presentation . Sputum cytology was positive in 8.33%. Endobronchial mass found in 40 (48.19%), vocal cord palsy in13(15.66%), trachial external compression in 8 (9.6%) ,widened carina in 19 (22.8%), bronchial external compression in 14(16.66%). BAL cytology was positive in 58.49% (31/53), brushing was positive in 60% ( 15/25) . Commenest presentation was lung mass (61.66%) on CXR and peripherial tumour 54 (57.45%) on CT. Adenocarcinoma was the commenst small cell carcinoma (48.33%), 50 (53.19 %) patients presented stage IV disease. Conclusion: Associated risk factors, symptoms, and investigations like CT guided FNAC, BAL cytology are enormously important to diagnose lung cancer in early stage so that further mortality & morbidity can be minimized.
Is renal amyloidosis uncommon in Egypt? A-25-year study

Background: Renal amyloidosis is a well-known disease. The forms of amyloidosis that are frequently associated with renal involvement are AL and AA amyloidosis. In Theodor Bilharz Institute, in Egypt, 2.5% of the total number of renal biopsies examined showed amyloidosis including secondary type in 80% and primary type in 20% of cases. Objectives: To investigate the prevalence of amyloidosis among Egyptian renal patients within 25 years and to screen the amyloid type whether AA or AL. Materials and Methods: Demographic and pathological data of archived renal biopsies presented to Ain Shams University hospitals in 25 years (1990-2015) were the material of this study. The diagnosis of all renal biopsies included in the study was confirmed by electron microscopy (EM). Immunohistochemical (IHC) staining of paraffin blocks for amyloid typing was carried out on archived material from (2010-2015). Results: Of a total number of 3962 biopsies examined; 118 were renal amyloidosis (2.97%). IHC typing of the screened samples revealed positive staining for amyloid A protein in 14 cases (73.68%). Light chain AL amyloidosis was found in 5 cases (26.3%). Conclusions: Renal amyloidosis is not uncommon in Egypt. AA amyloidosis represents the commonest type of renal amyloidosis in this study. The most common underlying disease was systemic inflammatory diseases, on top of familial Mediterranean fever (FMF).
Identification of Cellulosic Fibres by FTIR Spectroscopy DIFFERENTIATION OF FLAX AND HEMP BY POLARIZED ATR FTIR

Abstract The ability to identify accurately natural fibres is of importance to conservators, but this can prove problematic when dealing with fibres which possess similar chemistry and microstructure – the bast fibres flax and hemp are particularly challenging in this regard. Conventional techniques, such as microscopic examination, the measurement of fibre widths and the use of the twist test, will often prove unreliable, especially when dealing with degraded materials. This research has concentrated on the development of an attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopic technique employing polarized radiation to differentiate these two fibre types on the basis of the characteristic nature of the winding of their secondary cell walls: while the angle of fibrillar wind is roughly the same for both fibres (∼7°), the senses of wind are opposite – S (anti-clockwise) in the case of flax; Z (clockwise) for hemp. A crystallinity index, derived from the spectra, was found to vary in a systematic manner as the fibres were rotated with respect to the electric vector of the incident radiation. A good correlation between this variation and theoretical models was observed. It was found that the characteristic sense and angle of wind of the fibres could be determined, and thus hemp and flax distinguished.
Diagnóstico estructural de estructuras de madera históricas: La sala diplomática del Palacio Real de Nápoles

The aim of this article is to describe the diagnosis process made on the timber structure that holds up the vault of the Diplomatic Room of the Royal Palace in Naples (Italy). After a brief historical description of the Royal Palace and the Diplomatic Room, it discusses the methodology according to Italian regulations and the speci­fic problems that arose during the works. To complete the diagnosis, a dendrochronological analysis of the wooden elements was performed. The results show the residual mechanical properties of each structural element and the main problems to be resolved by the restorers. The dendrochronological conclusions yield that the dating of the elements is compatible with that of the frescoes on the vault and therefore demonstrate that the elements have not been replaced.
Motivation for Use of Information Technology by University Faculty: a developing country perspective

This study examined factors which motivate lecturers in Nigerian universities to use information technology (IT). A Diffusion of Innovations perspective was adopted for the study. The study employed a questionnaire for data collection. One thousand lecturers from ten universities in Nigeria were sampled. Seven hundred and eighteen completed questionnaires were found usable. The results found that perceived usefulness (relative advantage) and perceived ease of use (complexity) significantly influence the use of IT by lecturers in Nigerian universities. In addition, ease of use was found to be a stronger motivator for IT use than perceived usefulness. Furthermore, both training and level of access to IT significantly influenced the number of computer applications used by lecturers. In addition, level of access to IT was a significant predictor of both the number of computer applications used by lecturers and the frequency with which they used computers. The study concludes that even though innovation characteristics are important predictors of the adoption of IT by Nigerian university lecturers, organizational factors such as providing training and easy access to IT are even more important. Thus, programs aimed at integrating IT into developing country universities should provide effective and well-targeted training programs as well as easy access to IT for lecturers.
Referenciais teórico-metodológicos nas pesquisas em História da Educação: para uma história das relações entre sensibilidades, tempo livre e formação

Este escrito apresenta algumas das premissas do projeto A educacao dos sentidos na historia: o tempo livre como possibilidade de formacao (entre os anos finais do sec. XIX e os anos iniciais do sec. XXI). Seu intento basico e compartilhar nosso percurso para a criacao de condicoes para a construcao de uma historia da educacao dos sentidos e das sensibilidades em Minas Gerais no periodo compreendido entre os anos finais do seculo XIX e as primeiras decadas do seculo XXI, ainda que seu escopo va alem das fronteiras deste estado. Desenvolvido a partir de diferentes projetos de mestrado, doutorado e pos-doutorado, e baseado no trabalho empirico das alunas de Iniciacao Cientifica Luisa Cecilia Belotti Oscar, Caroline Maria Ferreira Drummond e Maria Daniela Donoso, o texto foca no subprojeto que tem como objetivo principal o mapeamento, a identificacao e a catalogacao de fontes relacionadas ao tema central, bem como o desenvolvimento de monografias que permitam compreender a relacao entre tempo livre, formacao e o desenvolvimento de sensibilidades entre as decadas finais do seculo XIX e as iniciais do XX. Entre varios arquivos mobilizados aqui, damos destaque ao Arquivo Publico Mineiro, a Hemeroteca e ao Setor de Obras Raras da Biblioteca Publica Luiz de Bessa e a Biblioteca da Assembleia Legislativa de Minas Gerais, todos em Belo Horizonte, nos quais e de grande relevância a presenca da imprensa periodica como possibilidade empirica.
Evaluation : methods for studying programs and policies

1. Setting the Scene. 2. Purposes of Evaluation. 3. Understanding the Program. 4. Planning the Evaluation. 5. Roles for the Evaluator. 6. Developing Measures. 7. Collecting Data. 8. Design of the Evaluation. 9. The Randomized Experiment. 10. Extensions of Good Design. 11. Qualitative Methods. 12. Analyzing and Interpreting the Data. 13. Writing the Report and Disseminating Results. 14. Evaluating with Integrity. Glossary. References. Index.
A measurement based Markov model for the indoor propagation channel

The assessment of a first order Markov model for data transmission on an indoor fading channel is investigated, on the basis of experimental data. The data have been obtained during the processing of a frequency profile database, stored during a broadband indoor measurement campaign in the 1.7-2.2 GHz band. The measurement has been carried on in a way, such that experimental sequences of signal to interference ratio, at the DECT frequency (1.89 GHz), have been able to be calculated. The sequences have been quantized, by comparison with a prefixed set of thresholds. The number of thresholds has been adopted equal to one or two. Statistical tests on obtained sequences seem to show that they can be generally modeled, as arising from a first order Markov chain, without dependence on chosen threshold values. Results obtained with two thresholds do exhibit less significance, due to the small amount of data.
Fast and Efficient Algorithms in Computational Electromagnetics

From the Publisher: Here's a cutting-edge resource that brings you up-to-date with all the recent advances in computational electromagnetics. You get the most-current information available on the multilevel fast multipole algorithm in both the time and frequency domains, as well as the latest developments in fast algorithms for low frequencies and specialized structures, such as the planar and layered media. These algorithms solve large electromagnetics problems with shorter turn around time, using less computer memory. Complex problems that once required a supercomputer to solve, can now be solved on a workstation or personal computer with the innovative methods taught in this resource. The book introduces you to new advances in the perfectly matched layer absorbing boundary conditions, and offers you a thorough understanding of error analysis of numerical methods, fast-forward and inverse solvers for inverse problems, hybridization in computational electromagnetics, and asymptotic waveform evaluation.
Level of Knowledge and Associated Factor toward Cervical Cancer among Women Age (21-64) Years Visiting Health Facilities in Gulele Sub-city Addis Ababa Ethiopia

Background Worldwide, cervical cancer is second most common health problem in women. Approximately 80% of cervical cancer occurs in developing countries. The magnitude of the problem has been under recognized and under prioritized compared to health priority such as HIV/AIDS, tuberculosis and malaria. Most cases of women with cervical cancer in sub-Saharan Africa present at advanced stage of the diseases, when treatment is ineffective or not available. Therefore the aim of this study was to assess the level of knowledge of women on cervical cancer and factors affecting their knowledge for cervical cancer in women who are visiting health facility which is found in Gulele sub-city Addis Ababa. Methods A facility based cross sectional study was conducted from January-April 2015 in Addis Ababa Gulele sub city. A total of 508 study participants whose age was 21-64 years were participated in the study. Astructured interview administered questionnaire was used to assess information. SPSS window version 21 was used for data entry and analysis. Result Of all the respondents 190 (37.4) were above average knowledge on cervical cancer. The knowledge of women on cervical cancer was found to be low. Education about the disease must include information on disease symptoms, treatment options, stages of curacy and prevention methods. Conclusions The result of this study revealed that knowledge of women on cervical cancer was low. The minister of health and stakeholders should have to give focus on the national policy of non-communicable prevention strategy to be effectively implemented in health facility. Client cantered regular health education about non-communicable disease like cervical cancer in health facility is important to increase women knowledge on the disease.
Interaction between grammar and multimodal resources: quoting different characters in Korean multiparty conversation

This article examines the interaction between grammar and multimodal resources by analyzing reported speech in Korean multiparty face-to-face interaction. The operation of two relevancy rules — minimization and recognition in interaction — is examined together with how the absence or presence of grammar is complemented by multimodal resources of various sorts. For the analysis, three categories (self-quotation, co-party quotation and third-party quotation) are posited depending on who the quoted character is in the talk. In quoting oneself or co-participants in the talk, syntactic resources, prosody, sequential organization and embodied participant frameworks collaborate in the interactional management of the quote without overt realization of grammatical resources traditionally proposed for building quotations in Korean. The multimodal character of quoted speech is most weakly realized when quoting a non-present (third-party) character, not only because of the limitation in body and spatial resources available in the local context to recover various referential terms, but more importantly, because the interactional project that the parties are engaged in makes a distancing device such as the quotative particle -ko relevant. This study provides evidence for the intricate interaction between multimodal resources and grammar through investigation of an important realm of human interaction, that of reported speech.
Whiplash Injuries, The Cervical Acceleration/Deceleration Syndrome

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Community based descriptive study on assessment of nutritional status among preschool children Pullipakkam village, Tamil Nadu

Nutrition by WHO: “The science of food and its relationship to heath, It is concerned primarily with the part played by nutrients in body growth, development and maintenance”. 1 The nutritional status is influenced by the adequacy of food intake both in terms of quantity and quality and also by physical health of individual. The nutrition assessment is to obtain precise information on the prevalence and geographic distribution of nutritional problems of a given community and identification of individuals at risk. Malnutrition is defined as pathological state resulting from a relative or absolute deficiency or excess of one or more essential nutrients. 1 The effects of malnutrition on the community are both direct and indirect. The direct effects are subclinical nutrition deficiency diseases such as kwshiorkar, marasmus, vitamin and mineral deficiency diseases and indirect effects are high morbidity, mortality among young children and delayed physical and mental growth and development. 1
Statistics A Guide To The Use Of Statistical Methods In The Physical Sciences

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