Miracle-dz/UniFAR-FTUs huggingface dataset:
Regional Ventilation in Infancy. Reversal of Adult Pattern

There is evidence that in infants with unilateral lung disease, oxygenation improves when the good lung is uppermost--the reverse of the situation in adults. We performed krypton-81m ventilation scanning in 18 infants and very young children (11 days to 27 months old) with and without abnormal chest radiographs. Scanning was performed with the subject supine, in the left decubitus posture (right lung uppermost), and in the right decubitus posture (right lung dependent). Fractional ventilation to the right lung fell when that lung was dependent and rose when it was uppermost (P less than 0.001). This pattern was seen regardless of the appearance of the chest radiograph. The distribution of ventilation away from dependent lung regions represents a reversal of the adult pattern, which may be due to differences between infants and adults in lung mechanics and diaphragmatic function. This study adds further weight to the argument that infants and very young children with unilateral lung disease should be positioned with their normal lung uppermost to optimize gas exchange. It also offers a rational explanation for the observation that infants with unilateral gas trapping can be successfully treated by placing them so that the diseased lung is dependent.
SATELLITE CELL REGULATION FOLLOWING MYOTRAUMA CAUSED BY RESISTANCE EXERCISE

It is generally accepted that the primary mechanisms governing skeletal muscle hypertrophy are satellite cell activation, proliferation, and differentiation. Specific growth factors and hormones modulate satellite cell activity during normal muscle growth, but as a consequence of resistance exercise additional regulators may stimulate satellite cells to contribute to gains in myofiber size and number. Present knowledge of the regulation of the cellular, biochemical and molecular events accompanying skeletal muscle hypertrophy after resistance exercise is incomplete. We propose that resistance exercise may induce satellite cells to become responsive to cytokines from the immune system and to circulating hormones and growth factors. The purpose of this paper is to review the role of satellite cells and growth factors in skeletal muscle hypertrophy that follows resistance exercise.
[The non Q wave myocardial infarction in conventional valvular surgery. Diagnosis with cardiac troponin I].

INTRODUCTION Morbidity and mortality in elective valve surgery is still significant. The main cause of death in these patients is cardiogenic shock, of which the most frequent etiology is acute myocardial infarction (AMI) with Q wave in the ECG. However, there are patients with cardiogenic shock without Q wave in the ECG and with rises in CK-MB enzyme that makes us suspect non-Q wave AMI. OBJECTIVE To analyze the use of the determination of cardiac troponin-I, a more specific marker of AMI than CK-MB after cardiac surgery, to detect perioperative non-Q wave AMI, and to establish its clinical significance. METHODS A total of 147 patients without coronary artery disease scheduled for elective valve surgery were included. We used, based in anterior publications, ECG (presence or not of new Q wave) and cardiac troponin I to define perioperative AMI. Levels of cardiac troponin-I were analysed before surgery and 14 hours after. Non-Q wave AMI was diagnosed when troponin I was superior to 38.85 ng/ml and there was not a phatologic Q wave in ECG. RESULTS One hundred twenty-three (83.67%) of patients did not have AMI, 9 (6.12%) suffered perioperative AMI with Q wave, and 15 (10.27%) carried out criteria of non-Q wave perioperative AMI. Morbidity and mortality in this last group was similar to that in the group with Q wave AMI. Morbidity and mortality were minimum in patients without AMI. CONCLUSIONS This study suggest the possibility of in vivo identification of non-Q wave perioperative AMI, an entity with important morbidity and mortality in our series, with a simple determination of cardiac troponin I 14 hours after surgery.
Prevalence of Pathological Internet Use in a Representative German Sample of Adolescents: Results of a Latent Profile Analysis

Background: Pathological internet use is of increasing significance in several industrial nations. Sampling and Methods: We surveyed a representative German quota sample of 1,723 adolescents (aged 14-17 years) and 1 caregiver each. We conducted a latent profile analysis to identify a high-risk group for pathological internet use. Results: Overall, 3.2% of the sample formed a profile group with pathological internet use. In contrast to other published studies, the results of the latent profile analysis were verified not only by self-assessments of the youth's but also by external ratings of the caregivers. In addition to the pathological internet use, the high-risk group showed lower levels of family functioning and life satisfaction as well as more problems in family interactions. Conclusions: The results showed a considerable prevalence of pathological internet use in adolescents and emphasized the need for preventive and therapeutic approaches.
A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi

Borrelia burgdorferi (Bb), the causative agent of Lyme disease, is transmitted to mammalian hosts through an arthropod (tick) vector. To establish infection, Bb must acquire essential nutrients, including transition metals, from its mammalian and tick hosts. Thus far, no metal transporter has been identified in Bb. Here, we report the identification of the first metal transporter, BmtA (BB0219), in Bb. BmtA-deficient mutants of virulent Bb were readily generated, and the mutants grew slightly slower than wild-type Bb in vitro. However, BmtA mutants were sensitive to the chelating actions of EDTA, suggesting a role for BmtA in metal utilization. Intracellular accumulation of manganese (Mn) was substantially diminished in the bmtA mutant, indicating that BmtA was operative in Mn uptake. Given that BmtA lacks homology to any known Mn transporter, we postulate that BmtA is part of a novel mechanism for Mn acquisition by a bacterial pathogen. BmtA also was essential to the infectious life cycle of Bb in ticks and mammals, thereby qualifying BmtA as a new borrelial virulence factor. In addition, the bmtA mutant was sensitive to treatment with t-butyl hydroperoxide, implying that BmtA, and thus Mn, is important to Bb for detoxifying reactive oxygen species, including those potentially liberated by immune effector cells during the innate immune response. Our discovery of the first molecule involved in metal transport in Bb provides a foundation for further elucidating metal homeostasis in this important human pathogen, which may lead to new strategies for thwarting Lyme disease.
Surviving Online Censorship in China: Three Satirical Tactics and their Impact

Abstract What accounts for online satirical campaigns that survive censorship in China where the state has formidable power to censor and manipulate online communication? Through comparative case studies of three attempts to challenge the policies or malpractices of the Chinese state in 2009, this article explains how different satirical tactics can influence the outcomes of online activism. It argues that online satirical campaigns are most likely to survive when activists adopt the tactic of “parodic satire,” whereby activists mimic a specific practice of the state and skilfully transplant it to other contexts. Since the language used by the activists resembles that of the powerful, the tactic allows netizens to exaggerate the internal contradictions of the policies or practices concerned without creating an easily identifiable symbol of resistance in the process. This tactic not only increases the cost to the state of censoring critical messages, but also restrains activists from extending their criticisms of the original subject to other areas. As a result, it increases the chance for the activists to exert insistent pressure on the state. 摘要 为何某些讽刺政府官员或政策的网络群众运动能避过中国严密的网络审查? 透过比较三个针对政府的讽刺运动, 本文厘清不同网络讽刺手法的分别, 并指出 “戏仿式讽刺” 最有可能在网络审查下生存。 戏仿者往往只是把其讽刺对象 (即政府) 的语言或做法有技巧地复制到其他语境以凸显其矛盾之处, 过程中不会产生一个明显的反抗符号。 此策略不但增加政府网络审查的成本, 同时亦防止其他参与戏仿者把运动的批判范围不断扩大, 因而较其他讽刺手法更能提高运动对政府持续施压的机会。
National e-government performance and citizen satisfaction: a multilevel analysis across European countries

Are citizens more satisfied with e-government ranked higher in league tables? In this article, we empirically examine the relationship between objective e-government performance on the supply side and the perceptions of citizens on the demand side. A multilevel analysis of over 28,000 respondents across 32 European countries reveals that highly ranked e-government is warmly welcomed by citizens, suggesting that the supply and demand sides of e-government are, in part, consistent. Specifically, the e-government performance–satisfaction correlations in e-service and e-participation are more prominent than that of e-information. The results also show that citizens’ perceived e-government benefits are mainly from using online services. While e-government rankings are reasonably predictive of citizen satisfaction, they should be referred to with caveats in e-government policies. Points for practitioners The empirical findings reveal that objective e-government performance is partially congruent with citizens’ satisfaction and perceived benefits. While e-government rankings may not be good predictors of citizen use, they do coincide, in part, with citizen satisfaction. Ubiquitous e-government benchmarks can be referred to as reliable gauges of citizen satisfaction, though their susceptibility varies across the purposes of e-government use. The various benefits that citizens perceived from e-government are primarily derived through online services instead of electronic information or participation, and the government should pay more attention to e-service development in order to bring more benefits to its users.
Role of hydroxyl containing residues in the intracellular region of rat bradykinin B2 receptor in signal transduction, receptor internalization, and resensitization

In past reports we illustrated the importance of Y131, Y322, and T137 within the intracellular (IC) face of the rat bradykinin B2 receptor (rBKB2R) for signal transduction and receptor maintenance (Prado et al. [ 1997 ] J. Biol. Chem. 272:14638–14642; Prado et al. [ 1998 ] J. Biol. Chem. 273:33548–33555). In this report, we mutate the remaining hydroxyl possessing residues located within the rBKB2R IC region. Exchange of S139A (IC2) or T239V (IC3) did not affect BK activated phosphatidylinositol (PI) turnover or receptor internalization. Chimeric exchange of the last 34 amino acids of BKB2R C‐terminus with the corresponding 34 amino acids of the rat angiotensin II AT1a receptor (rAT1aR), both containing an S/T cluster, resulted in a mutant with normal endocytosis and BK activated PI turnover. A more selective chimera of these S/T clusters, with an exchange of BKB2R (333–351) with a rAT1aR fragment (326–342), resulted in a receptor with a retarded internalization but a normal BK activated PI turnover. Subsequent mutation of rBKB2R T344V showed little change in receptor uptake but a pronounced loss of BK activated PI turnover. The mutation of S335A, S341A, S348A, and S350A resulted in very poor receptor internalization and loss of activated PI turnover. Closer examination of this serine cluster illustrated that the replacement of S348A led to poor internalization; whereas the retention of S348 and mutation of S341A resulted in a receptor with a much greater internalization than WT. These and other results suggest that the presence of S348 promotes internalization while the presence of S341 dampens it. Conversely, S341 and S350 proved important for receptor signaling. In sum, our results illustrate that the distal C‐terminus including its S/T cluster is important for both rBKB2R internalization and signal transduction. Individual S/T residues within this cluster appear involved in either signal transmission or receptor uptake capacity. However, replacement of the entire distal tail region with the corresponding rAT1aR sequence, also containing an S/T cluster, enables the BKB2R/AT1aR chimera to act in a very similar manner to wild type rBKB2R. J. Cell. Biochem. 83: 435–447, 2001. © 2001 Wiley‐Liss, Inc.
Velocity Loss as a Variable for Monitoring Resistance Exercise

Abstract This study aimed to analyze: 1) the pattern of repetition velocity decline during a single set to failure against different submaximal loads (50–85% 1RM) in the bench press exercise; and 2) the reliability of the percentage of performed repetitions, with respect to the maximum possible number that can be completed, when different magnitudes of velocity loss have been reached within each set. Twenty-two men performed 8 tests of maximum number of repetitions (MNR) against loads of 50–55–60–65–70–75–80–85% 1RM, in random order, every 6–7 days. Another 28 men performed 2 separate MNR tests against 60% 1RM. A very close relationship was found between the relative loss of velocity in a set and the percentage of performed repetitions. This relationship was very similar for all loads, but particularly for 50–70% 1RM, even though the number of repetitions completed at each load was significantly different. Moreover, the percentage of performed repetitions for a given velocity loss showed a high absolute reliability. Equations to predict the percentage of performed repetitions from relative velocity loss are provided. By monitoring repetition velocity and using these equations, one can estimate, with considerable precision, how many repetitions are left in reserve in a bench press exercise set.
Idelalisib

Objective: To review and summarize data on idelalisib, which was approved by the Food and Drug Administration (FDA) in July 2014 for use in combination with rituximab for relapsed chronic lymphocytic leukemia (CLL). Data Sources: A literature search using PubMed was conducted from January 2011 through May 2015 using the terms idelalisib, GS-101, CAL-101, PI3Kδ, and CLL. Data were also obtained through the FDA briefing documents, American Society of Clinical Oncology, and American Society of Hematology abstracts. Study Selection and Data Extraction: The literature search was limited to human studies published in English. Priority was placed on trials of idelalisib in CLL. Data Synthesis: Idelalisib is a potent, first-in-class selective inhibitor of phosphatidylinositol-3-kinaseδ (PI3Kδ) approved by the FDA in July 2014 for the treatment of relapsed CLL, in combination with rituximab, in patients for whom rituximab monotherapy would be considered appropriate due to other comorbidities. PI3Kδ is hyperactivated in B-cell malignancies and plays a vital role in the B-cell receptor pathway, a key oncogenic driver in various B-cell malignancies, including CLL. Several phase I/II studies have demonstrated clinical activity of idelalisib in CLL, particularly in the setting of relapsed/refractory disease, with overall response rate ranging from 70% to 82%. The FDA approval was based on a phase III, randomized trial of rituximab monotherapy (n = 110) or idelalisib in combination with rituximab (n = 110) in heavily, pre-treated patients (median of 3 prior therapies) with relapsed CLL. Idelalisib was administered as 150 mg orally twice daily. Idelalisib plus rituximab was associated with an overall response rate of 81% and overall survival of 91% at 12 months. The median progression-free survival was not reached in the idelalisib arm at the time of the first interim analysis. The incidence of grade 3 or higher adverse events in the idelalisib plus rituximab arm was as follows: neutropenia (34%), thrombocytopenia (10%), anemia (5%), elevation in transaminases (5%), and diarrhea (4%). Conclusion: Idelalisib in combination with rituximab is a safe and effective new treatment option for patients with relapsed CLL, including those with poor prognostic factors. As the results from various ongoing studies become available, the role of idelalisib will likely continue to expand.
Characterization of the Sinorhizobium meliloti sinR/sinI Locus and the Production of Novel N-Acyl Homoserine Lactones

ABSTRACT Sinorhizobium meliloti is a soil bacterium which can establish a nitrogen-fixing symbiosis with the legume Medicago sativa. Recent work has identified a pair of genes, sinR and sinI, which represent a potential quorum-sensing system and are responsible for the production of N-acyl homoserine lactones (AHLs) in two S. meliloti strains, Rm1021 and Rm41. In this work, we characterize the sinRI locus and show that these genes are responsible for the synthesis of several long-chain AHLs ranging from 12 to 18 carbons in length. Four of these, 3-oxotetradecanoyl HL, 3-oxohexadecenoyl HL, hexadecenoyl HL, and octadecanoyl HL, have novel structures. This is the first report of AHLs having acyl chains longer than 14 carbons. We show that a disruption in sinI eliminates these AHLs and that a sinR disruption results in only basal levels of the AHLs. Moreover, the same sinI and sinR mutations also lead to a decrease in the number of pink nodules during nodulation assays, as well as a slight delay in the appearance of pink nodules, indicating a role for quorum sensing in symbiosis. We also show that sinI and sinR mutants are still capable of producing several short-chain AHLs, one of which was identified as octanoyl HL. We believe that these short-chain AHLs are evidence of a second quorum-sensing system in Rm1021, which we refer to here as the mel system, for “S. meliloti. ”
Comparison of a pump‐around, a diffusion‐driven, and a shear‐driven system for the hybridization of mouse lung and testis total RNA on microarrays

In the present study, we demonstrate the benefits of a shear‐driven rotating microchamber system for the enhancement of microarray hybridizations, by comparing the system with two commonly used hybridization techniques: purely diffusion‐driven hybridization under coverslip and hybridization using a fully automated hybridization station, in which the sample is pumped in an oscillating manner. Starting from the same amount of DNA for the three different methods, a series of hybridization experiments using mouse lung and testis DNA is presented to demonstrate these benefits. The gain observed using the rotating microchamber is large: both in terms of analysis speed (up to tenfold increase) and in final spot intensity (up to sixfold increase). The gain is due to the combined effect of the hybridization chamber miniaturization (leading to a sample concentration increase if comparing iso‐mass conditions) and the transport enhancement originating from the rotational shear‐driven flow induced by the rotation of the chamber bottom wall.
Application of CSM-CERES-Maize model in optimizing irrigated conditions

Maize is one of the main cereal crops in Pakistan with sensitivity to drought at various developmental stages known to influence the yield. The impact of variable weather conditions on maize yield can be analyzed with crop simulation models. The CSM-CERES-Maize model has been widely used to assess irrigation strategies for maize. This research was conducted to test the CSM-CERES-Maize model for its ability to accurately predict maize biomass and grain yield under water limiting and non-limiting conditions in semiarid conditions. Four growth stage-based irrigation treatments and two potential soil moisture deficit-based treatments were defined. During model calibration, the simulated maximum leaf area index (LAI), total dry matter (TDM), and grain yield were all within 10% of observed values. During model evaluation, there was generally satisfactory agreement between observed and simulated values for two hybrids (Monsanto-919 and Pioneer-30Y87) with the model showing variability of −17.9–20.0%, −9.2–14.3%, and −19.6–19.9% for maximum LAI, TDM, and grain yield, respectively, for the two hybrids among various treatments. The CERES-Maize model was useful in providing information to decision-making regarding diverse irrigation regimes at the farm level in a semiarid environment.
Estimation of time-varying causal connectivity on EEG signals with the use of adaptive autoregressive parameters

In this paper, we address the problem of time-varying causal connectivity estimators on Electro-encephalographic (EEG) signals by means of Directed Transfer Function (DTF). The DTF method reveals causal information flows between brain areas, while direct DTF (dDTF) is able to distinguish and estimate only direct flows. Since neuro-physiological signals such as EEG and event related potentials (ERP) can be nonstationary, their temporal dynamics cannot be satisfactorily represented. Time-varying dDTF can be estimated using Kalman Filter for adaptive calculation of multivariate autoregressive coefficients. This approach can reveal transient causal relations and model time-dependent flow patterns. This approach was applied to simulated signals and the results indicated that time-varying dDTF can provide efficient estimates of connectivity patterns.
Herd Behavior in Emerging Equity Markets: Evidence from Vietnam

Abstract This study examines the herd behavior in Vietnam stock market using a sample of firms listed on the Ho Chi Minh City Stock Exchange covering the time period 2005–2015. We find evidence of herding in both rising and falling market employing the common least squares estimation. Further analysis by applying quantile regression method also confirms the evidence of herding during the whole period. The results are robust when we split the data into two sub-periods.
London’s rise as an offshore RMB financial centre: state–finance relations and selective institutional adaptation

ABSTRACT China’s currency, the renminbi (RMB), is increasingly important in global financial markets, facilitated by the global expansion of offshore RMB centres. This paper examines London’s development as the first Western offshore RMB centre established in 2013, drawing on original research conducted between 2013 and 2015 in London and China. The longitudinal analysis reveals that the development of RMB finance in London is characterized by selective adaptation in which state–private bargaining dynamics have shifted from strategic alignment to a bifurcation of interests. Understanding these state–finance relations has important implications for research and policy-making concerned with (offshore) financial centres and RMB internationalization.
Students' and teachers' perceptions of effective teaching and learning in the middle level science classroom: the effects on student achievement

iii ACKNOWLEDGMENTS v LIST OF TABLES ix LIST OF FIGURES x LIST OF APPENDICES xi CHAPTER 1 CONTEXT OF THE STUDY 1 ORIGIN OF THE STUDY 2 BACKGROUND OF THIS STUDY 3 PURPOSE OF THE STUDY 6 Statement of the Problem Research Hypothesis and Research Questions SIGNIFICANCE OF THE STUDY 6 7 8 RESEARCH DESIGN OF THE STUDY 9 Theoretical Framework of the Study Overview of the Methodology Overview of the Thesis 9 9 11 CHAPTER SUMMARY 11 CHAPTER 2 REVIEW OF THE LITERATURE POSITIONING THE