Miracle-dz/UniFAR-FTUs huggingface dataset:
Endovascular Brachytherapy Using Liquid Beta-Emitting Rhenium-188 for the Treatment of Long-Segment Femoropopliteal In-Stent Stenosis

Purpose To evaluate the efficacy and safety of endovascular brachytherapy with liquid beta-emitting rhenium-188 (Re-188) in patients with long-segment in-stent stenosis in the femoropopliteal segment. Methods From July 2009 to April 2011, 90 consecutive patients (59 men; mean age 68.3±10.3 years, range 43–86) with symptomatic in-stent stenosis/occlusion (24.6-cm mean lesion length) of the femoropopliteal segment underwent angioplasty and subsequent endovascular brachytherapy. The liquid beta-emitting Re-188 was applied to the target lesion within an angioplasty balloon using a dose of 13 Gy at a depth of 2 mm into the vessel wall. Clinical and angiographic follow-up data were collected up to 2 years. The main study endpoints were the 6- and 12-month primary patency rates defined as <50% in-stent stenosis as detected by duplex ultrasound. Clinical endpoints were the cumulative rates of death, amputation, and bypass surgery, as well as improvement in the Rutherford category and the ankle-brachial index. Results were correlated with patient and lesion characteristics. Results Primary technical success was achieved in all patients, with 1 early stent thrombosis, but no other complications related to the irradiation. Eighty-eight patients reached the 6-month and 82 the 12-month examinations; the primary patency was 95.2% and 79.8%, respectively. In-stent stenosis occurred in 9 patients, while 10 patients had reocclusion of the treated segment. During follow-up, there were 2 late acute thrombotic occlusions, both after discontinuation of clopidogrel. The clinical status improved in 67.0% and 62.2% of the patients after 6 and 12 months, respectively. No patient, lesion, or procedure variables were predictive of restenosis after EVBT. Conclusion EVBT with liquid beta-emitting Re-188 was safe and effective in preventing restenosis in long-segment femoropopliteal ISS.
Underserved patients' choice of kiosk-based preventive health information.

BACKGROUND AND OBJECTIVES Compliance with health promotion recommendations falls short of expectations nearly every time it is studied. Some of the most successful programs, however, focus on the patient and incorporate computers. METHODS Interactive kiosks in waiting rooms of clinics for the medically underserved were used to educate patients about alcohol consumption, exercise, smoking cessation, and weight control. RESULTS Kiosks were accessed 11,401 times. Users averaged 40 years old, and most had at least a high school education and an average body mass index (BMI) of 29.8. Sixty percent were white, and 64% were women. Weight control garnered the most interest followed by smoking cessation. Those overweight and men with sleep disorders were more interested in weight control. Smokers and depressed women were most interested in smoking cessation. Men who were older, Latino, or had high blood pressure and women who were overweight were most interested in exercise. Those interested most in alcohol consumption were men who were white, drink alcohol, or married and women who were younger, single, black, Latino, or smoke. CONCLUSIONS These results add to our understanding of underserved populations and individuals who might be more receptive to preventive health interventions so that educational efforts might be more likely to result in behavior change.
A Simple Psychophysiologic Technique Which Elicits the Hypometabolic Changes of the Relaxation Response

&NA; Oxygen consumption, carbon dioxide production, and respiratory rate are significantly decreased during the practice of a new, easily‐learned relaxation technique. The elements of the technique are a mental device to prevent distracting thoughts, a passive attitude, decreased muscle tonus, and a quiet environment which is as free of visual and auditory stimuli as possible. Sitting quietly with the eyes either open or closed failed to produce the same changes. These physiologic changes are consistent with an integrated hypothalamic response resulting in hypothesized decreased sympathetic activity. This response has recently been termed the “relaxation response. ”
Soluble thrombomodulin partially corrects the premature lysis defect in FVIII‐deficient plasma by stimulating the activation of thrombin activatable fibrinolysis inhibitor

Summary. Background: Previous work by others has shown that premature clot lysis occurs in plasmas deficient in components of the intrinsic pathway, due to a failure to activate thrombin activatable fibrinolysis inhibitor (TAFI). This suggests the hypothesis that bleeding in hemophilia is due not only to defective coagulation but also enhanced fibrinolysis. These studies were carried out to quantify the extent of TAFI activation over time in normal plasma (NP) and factor VIII deficient plasma (FVIII‐DP) and to determine whether soluble thrombomodulin (sTM) can correct the lysis defect in FVIII‐DP. Methods: The time courses of TAFI activation in both NP and FVIII‐DP were monitored after clotting with thrombin, PCPS and Ca2+, ± sTM. Clotting and lysis were measured turbidometrically and TAFIa using a functional assay. Results: Premature lysis that occurs in FVIII‐DP is corrected by mixing deficient plasma with 10% NP. However, this does not fully correct the defect in TAFI activation. FVIII‐DP must be mixed with up to 50% NP to attain the same TAFIa potential as NP. In FVIII‐DP, sTM can correct the defect in TAFIa‐dependent prolongation of lysis at low tPA concentrations and partially correct this defect at high tPA concentrations. Conclusions: TAFI activation increases as the concentration of FVIII increases. FVIII at a level of 10% fully corrects the lysis defect in spite of the extent of TAFI activation being only one half that obtained with 100% FVIII. In addition, sTM increases TAFI activation sufficiently to correct the premature lysis defect in FVIII‐DP.
An electron microscopic study of local anesthetic‐induced skeletal muscle fiber degeneration and regeneration in the monkey

An electron microscopic study was done on abductor pollicis brevis muscles of 18 Rhesus monkeys after intramuscular injections of 0.75% bupivacaine, 2% mepivacaine, or 2% lidocaine + epinephrine. The muscles were examined for from 2 h to 28 days. Severe muscle fiber damage, consisting of breakdown of sarcolemma and myofibrils, was seen as early as 2 h. Phagocyte‐mediated fragmentation of the degenerating muscle fibers was at its peak during the third and fourth days. Myoblasts were abundant during the fourth day. Early myotubes appeared on the fifth and sixth days, and they matured during the second week. Satellite cells appeared alongside mature myotubes. Overall, the local anesthetic‐induced breakdown and regeneration of skeletal muscle fibers in the monkey followed a course quite similar to that seen in the rat.
Calcium/cadmium interactions at uptake surfaces in rainbow trout: Waterborne versus dietary routes of exposure

Juvenile rainbow trout (Oncorhynchus mykiss) were exposed to control, 3 μg/L waterborne Cd, or 500 mg/kg dietary Cd in combination with either a control (20 mg/g Ca2+ as CaCO3) or elevated (60 mg/g Ca2+) Ca2+ diet for 28 d. No mortality or growth effects were observed in response to either route of Cd exposure, although fish fed Ca2+‐supplemented diets exhibited minor reductions in growth within the first few days of feeding. Waterborne and dietary Cd resulted in significant Cd accumulation in most tissues, with dietary uptake being far in excess of waterborne under the exposure conditions used. The order of Cd accumulation strongly reflected the exposure pathway, being gill and kidney > liver > gut > carcass (waterborne Cd); gut > kidney > liver > gill > carcass > bone (dietary Cd). On a whole‐body basis, the net retention of Cd from the diet was <1%, indicating that the gut wall forms an important protective barrier reducing Cd accumulation into internal tissues. Dietary Ca2+ supplementation reduced short‐term whole‐body uptake rates of waterborne Ca2+ and Cd by >50% and resulted in much lower chronic accumulation of Cd (via the water and diet) in target tissues. Results suggest that Ca2+ and Cd share common pathway(s)/transport mechanism(s) in the gill and gut and that increased gastrointestinal Ca2+ uptake likely caused downregulation of branchial and gastrointestinal Ca2+ and therefore Cd uptake pathways. Because nutrient metals other than Ca2+ may also influence Cd (and other metal) uptake, new regulatory approaches to metal toxicity (e.g., biotic ligand model) require understanding of the influence of dietary status on metal accumulation.
The Wheelchair Procurement Process: Perspectives of Clients and Prescribers

Background. Increasing choices in assistive technology have made the process of procuring a wheelchair more complex and challenging. Purpose. To explore the intricacies of the procurement process from the perspectives of clients and therapists. Methods. Thirty-four participants were interviewed, including 13 wheelchair prescribers, 14 wheelchair users, and 7 wheelchair associates (family members and caregivers). Findings. Analysis revealed five main themes. “Who decides? ” described varying degrees of client involvement in the procurement process. “Expert knowledge” reflected the expert knowledge that all parties possessed. “Form versus function” captured the primary and, at times, conflicting outcomes that participants wanted to achieve. “Fitting in” depicted the environmental factors that affected wheelchair procurement. “(Re)solutions” illustrated strategies that participants felt improved the process. Implications. This study reveals clients' experiences with wheelchair procurement, identifies potential issues therapists may encounter, and suggests possible remedies they might consider when prescribing wheelchairs within a client-centred framework.
Robust 90-nm RF CMOS device models for RFIC design

This paper addresses a key concern of RFIC designers: RF device models are extracted from measurements of common source (CS) devices, but are used in un-common source (UCS) RFIC designs. As well as validating RF models in a complete functional IC, we also introduce flexible active building cells, i.e. intermediate merged cascode cells (MCC) and cross couple pairs (CCP). A good match between measurements and simulations of a MCC and CCP verify the accuracy and reliability of foundry provided RF models. To further demonstrate the CS effect on UCS design in RF applications, a single ended 5 GHz LNA is implemented with first pass design success. Measured results match well with post-simulations. The LNA delivers state-of-the-art performance, with a NF of 3±0.5 dB and 16 dB gain. The 1-dB compression point of −3 dBm is achieved with a supply current of 13mA. The methodology presented here should be applicable to other technology nodes. A 90-nm CMOS process has been used in the current work.
Communist parties in transition: structures, leaders, and processes of democratization in Eastern Europe

En Albanie, Bulgarie, Republique tcheque, Slovaquie, Estonie, Hongrie, Lettonie, Lithuanie, Pologne et Roumanie, les partis communistes ont du s'adapter au changement politique. Des facteurs lies a l'environnement (recompensense electorales, opportunites politiques et structure de competition entre les partis) et des facteurs internes (heritage historique et dynamique de la transition) affectent l'equilibre des forces a l'interieur du parti
Stabilization of MyoD by Direct Binding to p57Kip2 *

Recent data have demonstrated the role of Cdk1- and Cdk2-dependent phosphorylation of MyoDSer200 in the regulation of MyoD activity and protein turnover. In the present study, we show that in presence of p57Kip2, MyoDAla200, a MyoD mutant that cannot be phosphorylated by cyclin-Cdk complexes, displayed activity 2–5-fold higher than of MyoDAla200 alone in transactivation of muscle-specific genes myosin heavy chain, creatine kinase, and myosin light chain 1. Furthermore, p57Kip2 increases the levels of MyoDAla200 in cotransfected cells. This result implies that p57Kip2 may regulate MyoD through a process distinct from its function as a cyclin-dependent kinase inhibitors. We report that overexpression of p57Kip2 increased the half-life of MyoDAla200. This increased half-life of MyoD involves a physical interaction between MyoD and p57Kip2but not with p16Ink4a, as shown by cross-immunoprecipitation not only on overexpressed proteins from transfected cells, but also on endogenous MyoD and p57Kip2from C2C12 myogenic cells. Mutational and functional analyses of the two proteins show that the NH2 domain of p57Kip2 associates with basic region in the basic helix-loop-helix domain of MyoD. Competition/association assays and site-directed mutagenesis of the NH2 terminus of p57Kip2 identified the intermediate α-helix domain, located between the Cdk and the cyclin binding sites, as essential for MyoD interaction. These data show that the α-helix domain of p57Kip2, which is conserved in the Cip/Kip proteins, is implicated in protein-protein interaction and confers a specific regulatory mechanism, outside of their Cdk-inhibitory activity, by which the p57Kip2 family members positively act on myogenic differentiation.
Postprandial concentrations of free and conjugated bile acids down the length of the normal human small intestine

Small intestinal samples were obtained by intubation from multiple sites along the small intestine in 11 subjects with no known gastrointestinal disease eating a normal diet and at laparotomy in a further three subjects. Free (unconjugated) bile acids were consistently demonstrated in ileal samples, and occasionally in lower jejunal samples, by thin-layer chromatography, supplemented in some cases by gas/liquid chromatography and by infrared spectroscopy. The free bile acid concentration, measured enzymically following thin-layer chromatography, reached a maximum (1 mM) in the lower ileum, where it represented half the total bile acid concentration. Following ampicillin, the concentration of free bile acids decreased markedly, suggesting that they resulted from bacterial deconjugation; at the same time the total bile acid concentration increased, suggesting impaired absorption due to the reduced concentration of the more rapidly absorbed free bile acids. Our results indicate that the presence of free bile acids in lower jejunal and ileal samples is a normal finding, and cannot be taken as evidence of abnormal bacterial overgrowth. They also suggest that bacterial deconjugation at these sites may be a factor contributing to the remarkable efficiency of bile salt reabsorption.
Sooty mangabeys use auditory cues to scavenge on nuts cracked by chimpanzees and red river hogs

Citation for published version (APA): Van Pinxteren, B. O. C. M. , Sirianni, G. , Gratton, P., Després-Einspenner, M-L. , Egas, M. , Kühl, H. , Lapuente, J., Meier, A. C. , & Janmaat, K. R. L. (2018). Sooty mangabeys use auditory cues to scavenge on nuts cracked by chimpanzees and red river hogs: An investigation of inter-specific interactions around tropical nut trees. American Journal of Primatology, 80(8), [e22895]. https://doi.org/10.1002/ajp.22895
Pharmacotherapeutic strategies for pediatric bipolar disorder

There has been a recent increase in recognition and diagnosis of pediatric bipolar disorder (PBD), along with an increase in prescriptions for psychotropic medications for treating children suffering from this chronic, potentially disabling disorder. Lithium remains the only FDA-approved mood stabilizer for use in children > 12 years of age and along with valproic acid and carbamazepine, forms the triad of traditional mood stabilizers used for initiation of treatment for PBD. There has been a recent surge in the use of atypical antipsychotics in PBD, which may be due to their relative ease of administration and lack of requirement for serum level monitoring. A combination of traditional mood stabilizers along with atypical antipsychotics is commonly used in clinical practice, despite a lack of compelling empirical data. Although there is an urgent need for controlled studies on the available treatment options and strategies in PBD, recent expert consensus guidelines and emerging controlled pharmacotherapy data on PBD will lay the platform for future scientific research in the area.
Naked Consumer's Mind Under Branded Dress: Case Study of Slovak Republic

The reality of the market has shown that traditional brand management theory lacks success. There is a need to provide a revision to this theory with an emphasis on behavioral approach. In contemporary times, the theory has been limited mainly in this criterion and to avoid from the exact identification of specific brand value sources in conditions of particular nations. Therefore, the aim of this paper is to identify relevant brand value sources which are significant for Slovak socio-cultural profile and to propose an effective innovative model of brand value building and management. The data used in the presented study were obtained by our own survey carried out on the sample of 2000 respondents (citizens of the Slovak Republic older than 15 years). The given data was statistically evaluated by the so-called factor analysis supported by implementation of the KMO Test, Barlett's test of sphericity and calculation of Cronbach's Alpha (for individual brand value sources and their components in general as well as on the example of sportswear brands). The specificities of the national socio-cultural profiles were found to be identical in the priority of the components of the individual, subjectively perceived sources of the brand value. In contrast, the order of importance of brand sources is different and reflects the specificity of the branded product category. Therefore, the specifics of the national socio-cultural profile affect the priority of the components of the individual brand value sources, while the specifics of the product categories affect the priority of the brand value sources itself.
Computerizing Social-Emotional Assessment for School Readiness: First Steps toward an Assessment Battery for Early Childhood Settings.

TheJournal of Applied Research on Childrenis brought to you for free andopen access byCHILDREN AT RISKatDigitalCommons@The TexasMedical Center. It has a"cc by-nc-nd" Creative Commons license"(Attribution Non-Commercial No Derivatives) For more information,please contactdigitalcommons@exch.library. tmc.edu
Chemotaxis toward amino acids by Bacillus subtilis

Conditions for assaying chemotaxis in Bacillus subtilis are described. The chemotaxis medium we used afforded excellent motility for hours. In it, chemotaxis measured by capillary assays was insensitive to pH between 5.5 and 9, and to temperature between 28 degrees C and 42 degrees C. Chemotaxis was observed toward all 20 common amino acids, with thresholds varying from 3nM for alanine to 0.1 mM for glutamate, in the capillary assay, and from 0.1 muM for alanine to 0.32 mM for glutamate in the microscope assay.
Coenzyme Q10: another biochemical alteration linked to infertility in varicocele patients?

Previously we demonstrated that coenzyme Q10 (CoQ10) is present in human seminal fluid and shows a direct correlation with seminal parameters except in patients with varicocele (VAR). We have now evaluated CoQ10 distribution in VAR, versus control subjects, in order to discover metabolic abnormalities within this condition. We studied 32 patients with VAR (11 with oligoasthenozoospermia, 13 with asthenozoospermia, and 8 with normozoospermia), and, as controls, the following groups of subjects, matched with VAR patients according to seminal parameters: 16 patients with idiopathic oligozoospermia, 11 patients with isolated asthenozoospermia, and 14 normal fertile men. CoQ10 was assayed in total seminal fluid, plasma, or cell pellet by high-performance liquid chromatography (HPLC). We found a significantly higher proportion of CoQ10 in seminal plasma in VAR; cellular CoQ10 showed an inverse correlation with sperm concentration and motility in VAR, at variance with controls. As seminal plasma ubiquinone reflects an interchange between intracellular and extracellular compartments, the different distribution in VAR patients could represent a greater sensitivity to peroxidative damage and could suggest reduced utilization for energy, which in turn could cause a defective motility even in patients with a normal cell count. These data suggest a pathophysiological role of CoQ10 in seminal plasma and a possible molecular defect in VAR.
Biochemical Composition and Cariogenicity of Dental Plaque Formed in the Presence of Sucrose or Glucose and Fructose

The composition of dental plaque formed in the presence of sucrose or glucose and fructose and its relation to cariogenicity was evaluated. Twelve adult volunteers took part in this crossover study done in three phases of 28 days each. For each phase, an acrylic resin appliance containing four human dental enamel blocks was constructed for the volunteers. Solutions containing 20% sucrose or 10% glucose + 10% fructose were dripped onto the enamel blocks 8 times a day, while in the control group no solution was used. Enamel surface and cross–sectional microhardness results showed that dental plaque formed in the presence of sucrose was more cariogenic than that formed in the presence of glucose + fructose (p<0.05). The concentration of alkali–soluble carbohydrates in dental plaque was higher in the sucrose group than in the control and glucose + fructose groups (p<0.05). Although concentrations of Ca, P and F were lower in plaque formed in the presence of sucrose than glucose + fructose and the control, significant differences (p<0.05) were only observed in relation to control. The electrophoretic profile of the matrix proteins of dental plaque showed distinct patterns when it was formed in the absence or presence of the different carbohydrates. Although the results suggest that the high cariogenicity of dental plaque formed in the presence of sucrose can be mainly explained by the high concentration of insoluble glucans of its matrix, the low inorganic concentration and its protein composition may have some contribution.
The Ser/Thr/Tyr phosphoproteome of Lactococcus lactis IL1403 reveals multiply phosphorylated proteins

Recent phosphoproteomics studies of several bacterial species have firmly established protein phosphorylation on Ser/Thr/Tyr residues as a PTM in bacteria. In particular, our recent reports on the Ser/Thr/Tyr phosphoproteomes of bacterial model organisms Bacillus subtilis and Escherichia coli detected over 100 phosphorylation events in each of the bacterial species. Here we extend our analyses to Lactococcus lactis, a lactic acid bacterium widely employed by the food industry, in which protein phosphorylation at Ser/Thr/Tyr residues was barely studied at all. Despite the lack of almost any prior evidence of Ser/Thr/Tyr protein phosphorylation in L. lactis, we identified a phosphoproteome of a size comparable to that of E. coli and B. subtilis, with 73 phosphorylation sites distributed over 63 different proteins. The presence of several multiply phosphorylated proteins, as well as over‐representation of phosphothreonines seems to be the distinguishing features of the L. lactis phosphoproteome. Evolutionary comparison and the conservation of phosphorylation sites in different bacterial organisms indicate that a majority of the detected phosphorylation sites are species–specific, and therefore have probably co‐evolved with the adaptation of the bacterial species to their present‐day ecological niches.