Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical features and management

Cats suffering from this disease were first recognized in late 1981. During the early months of 1982 the number of cases increased dramatically, and reached a peak in July, when we saw as many cases as in the previous 6 months put together. There may have been a drop in numbers during the winter of 1982 but a large number of cats were affected during 1983. Cases are continuing to occur but I have no accurate figures on incidence. However, a number of interested colleagues in practice in various parts of the United Kingdom have agreed to log their cases during the next year and this should give us a better picture of incidence totals, plus any indications of regional and seasonal variations. The pattern of the disease does not appear to have altered since it first appeared. Usually it occurs sporadically, with one cat in a household affected. However, there have been a number of instances in which several kittens in a litter have been affected, and pairs of related or unrelated cats in the same house have become ill at the same time. In other cases individual cats in adjacent houses have become ill at the same time, and instances have occurred where another cat in a previously affected household has developed the disease up to 12 months later. Nevertheless, these occurrences have tended to be the exception rather than the rule. Country cats as well as town cats have been affected and the disease has occurred in animals kept permanently indoors as well as in those allowed total freedom. Domestic short-haired cats have outnumbered pure-bred cats affected by about 4 : 1, and males to females by 3 : 2. Seventy five per cent of affected cats have been less than 3 years old at the onset of the disease with an overall age range of 2 months to 11 years. In most cases the owner reports that the disease has developed quite suddenly. Not infrequently many of the major signs have appeared in less than 12 hours. In other cases (about 30 per cent) the onset is more prolonged, up to one week, with the cat becoming vaguely ill prior to the onset of recognizable signs. The presenting signs vary, but generally consist of one or more of dullness, anorexia, ‘vomiting’, and ocular changes become apparent early on. In some cases, the change from healthy normality to severely ill has occurred so quickly and dramatically that a road accident has been suspected.
Identification of triacylglycerols in the enzymatic transesterification of rapeseed and butter oil

A blend of rapeseed and butter oil was transesterified using immobilized Thermomyces lanuginosus lipase (Lipozyme (R) TL IM) as catalyst. The reaction was followed by reversed-phase HPLC and the triacylglycerol peaks were tentatively identified from their elution times by calculating equivalent carbon numbers. Further identification was made using HPLC-electrospray tandem mass spectrometry. A few of the triacylglycerols detected were typical combinations of fatty acids originating from rapeseed oil, such as alpha-linolenic acid, and short-chain fatty acids from butter oil. Due to the regioselectivity of the lipase, the transesterification reaction involved mainly fatty acids in the sn-1 and sn-3 positions. However, significant changes in the fatty acid composition in the sn-2 position were detected after 6 h. (Less)
Recurrent Symptomatic Subependymoma: Case Report and Review of the Literature

Subependymomas are rare benign neoplasms that arise from the lateral, third, and fourth ventricles; the septum pellucidum; the aqueduct; and the proximal spinal cord. They are usually slow growing, benign, and often asymptomatic. Consequently, they are most frequently discovered on autopsy. Some do become symptomatic, however, and because of their location or size, they cause hydrocephalus or neurologic deficits. When a subependymoma becomes symptomatic, gross resection is indicated whenever possible. Patients generally have a good prognosis after gross resection (except in fourth ventricle tumors). Subependymomas are sensitive to radiotherapy; however, radiotherapy is not considered necessary after gross resection, because the lesion generally does not recur. In the patient described in this report, despite initial gross resection and radiotherapy, the subependymoma did recur nearly 15 years after initial surgical treatment. Because it was symptomatic, gross total resection was again performed.
Measurements of POI-based mixed use and their relationships with neighbourhood vibrancy

ABSTRACT Although mixed use is an emerging strategy that has been widely accepted in urban planning for promoting neighbourhood vibrancy, there is no consensus on how to quantitatively measure the mix and the effects of mixed use on neighbourhood vibrancy. Shannon entropy, the most commonly used diversity measurement in assessing mixed use, has been found to be inadequate in measuring the multifaceted, multidimensional characteristics of mixed use. And lack of data also makes it difficult to find the relationship between mixed use and neighbourhood vibrancy. However, the recent availability of new sources including mobile phone data and Point of Interest (POI) data have made it possible to develop new indices of mixed use and neighbourhood vibrancy to analyse their relationships. Taking advantage of these emerging new data sources, this study used the numbers of mobile phone users in a 24-hour period as a proxy of neighbourhood vibrancy and used POIs from a navigation database to develop a series of mixed-use indicators that can better reflect the multifaceted, multidimensional characteristics of mixed-use neighbourhoods. The Hill numbers, a unified form of diversity measurement used in ecological literature that includes richness, entropy, and the Simpson index, are used to measure the degrees of mixed use. Using such fine-grained data sets and the Hill numbers allowed us to obtain better insights into the relationship between mixed use and neighbourhood vibrancy. Four models varying in POI measurements that reflect different dimensions of mixed use were presented. The results showed that either POI density or entropy can explain approximately 1% of neighbourhood vibrancy, while POI richness contributes significantly in improving neighbourhood vibrancy. The results also revealed that the entropy has limitations as a measure for representing mixed use and demonstrated the necessity of adopting a set of more appropriate measurements for mixed use. Increasing the number of POIs has limited power to improve neighbourhood vibrancy compared with encouraging the mixing of complementary POIs. These exploratory findings may be useful for adjusting mixed-use assessments and to help guide urban planning and neighbourhood design.
Housing Environment Important for Retirement

The purpose of this study was to determine environmental factors important to women and men faculty approaching retirement. Data were collected by means of the Dillman survey method. The population included faculty above forty years of age at five western land-grant universities. Environmental factors studied were neighborhood preferences, general services, migration characteristics and geographic conditions. Results indicate differences between general population and university faculty as well as gender.
Adolescent health care - is it a forgotten and neglected field? Challenges for the twenty first century: A review of the literature

A large number of article reports have identified many gaps in adolescent health care. Opsomming Die leemtes in die gesondheidsorg van adolessente word in 'n groot aantal artikels aangedui. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.
Twin reversed arterial perfusion (TRAP) sequence managed at 11+6 weeks with radiofrequency ablation

Abstract Radiofrequency ablation (RFA) has become widely accepted as first-line management for twin reversed arterial perfusion (TRAP) sequence. Most RFA procedures have been performed using RFA needles of 14–17 gauge (G) focusing on an acardiac mass at an average age of 21 weeks of gestation (17–24 weeks). In this case report, we describe treatment of TRAP sequence using RFA with a 20 G needle focusing a feeding artery on the placental surface at gestational age of 11+6.
Quantitative meta‐analysis of grey matter anomalies in neuropathic pain

Increasing neuroimaging studies have revealed grey matter (GM) anomalies of several brain regions by voxel‐based morphometry (VBM) studies in patients with neuropathic pain. The changes have been suggested to be related to central sensitization. Our aim was to investigate concurrence across VBM studies to identify whether different subtypes of neuropathic pain share a common pathophysiological basis revealed by structural abnormalities.
Workplace policies and mental health among working-class, new parents

ABSTRACT Little research has explored linkages between workplace policies and mental health in working-class, employed parents, creating a gap in our knowledge of work–family issues across social class levels. The current US study addresses this gap by employing hierarchical linear modeling techniques to examine how workplace policies and parental leave benefits predicted parents’ depressive symptoms and anxiety in a sample of 125, low income, dual-earner couples interviewed across the transition to parenthood. Descriptive analyses revealed that, on average, parents had few workplace policies, such as schedule flexibility or child care supports, available to them. Results revealed, however, that, when available, schedule flexibility was related to fewer depressive symptoms and less anxiety for new mothers. Greater child care supports predicted fewer depressive symptoms for fathers. In terms of crossover effects, longer maternal leave predicted declines in fathers’ anxiety across the first year. Results are discussed with attention to how certain workplace policies may serve to alleviate new parents’ lack of time and resources (minimize scarcity of resources) and, in turn, predict better mental health during the sensitive period of new parenthood.
Anti - inflammatory Effects of Quranic Plants' Mixture : A New Pharmaceutical Product

Aims : T his work was carried out to determine anti - inflammatory effects of this new pharmaceutical product ( Quranic Plants’ Mixture) and also to study side effects of this product on many important organs of the body of investigated animals. Place and Duration of the Study: I n vivo studies were carried out in the Animal House of the National Research Centre, Dokki, Giza, Egypt (during 21 - 22 July 2014). Histological studies of investigated animals were done in the Pathology Department Lab, Theodor Bilharz Research Institute, Giza, Eg ypt . Study Design : Three different doses of this new pharmaceutical product were tested in this study regarding their anti - inflammatory effects. Methodology: In vivo studies of anti - inflammatory effects of feeding adult female albino rats under investigation with three different doses (2, 4 and 8 g/kg ) of this new pharmaceutical product were carried out after 24 hours of inducing inflammation by injecting investigate d animals with carrageen. Additionally, weights of many important organs ( Brain, Kidney, Liver, Heart, Lung, Spleen, Stomach and Colon ) of the body of investigated animals were measured, along with investigations of their histological structures, to examin e any bad side effects of this new pharmaceutical product on investigated animals. Results: In vivo studies of anti - inflammatory effects of feeding adult female albino rats under investigation with three different doses (2, 4 and 8 g/kg ) of this new pharm aceutical product Original Research Article
A Randomized, Controlled Trial of a Neurological and Psychoeducational Group Appointment Model for Pediatric Headaches

This study evaluated the effectiveness of a multidisciplinary group appointment model for pediatric headaches. Eighty-one patients ages 10 to 18 were randomly assigned to a Traditional Clinic Model (TCM) or a Headache Clinic (HCM) Model for the initial neurological appointment. In addition to a neurological evaluation, the HCM included a group educational session describing stressors contributing to pain, pharmaceutical and behavioral treatments, and guided relaxation skills practice. HCM patients demonstrated greater gains in headache knowledge and required slightly less physician face-to-face time than TCM patients. Both groups experienced a sustained decline of about 40% in headache-related disability and high treatment satisfaction.
Health-related quality of life in people with severe aphasia.

BACKGROUND Health-related quality of life (HRQL) measures are increasingly used to help us understand the impact of disease or disability on a person's life and to measure the effectiveness of interventions. A small number of studies have looked at perceived HRQL in people with mild or moderate aphasia. They report that reduced HRQL is associated with low psychological well-being and depression, reduced activity levels and high levels of communication disability. Still, very little is known about the quality of life of people with severe aphasia. AIMS This study aimed to evaluate the HRQL of people with severe aphasia as rated by their proxy respondents. To increase our understanding of these proxy evaluations, the findings were compared with those of two other studies of HRQL in people with moderate or mild aphasia, using proxy and self-report respondents. METHODS & PROCEDURES A questionnaire-based cross-sectional survey was carried out where proxies of people with severe aphasia reported on their HRQL. The people with severe aphasia who took part in this study were part of a larger cohort of people with aphasia who were able to self-report on their HRQL. Aphasia was assessed with the American Speech and Hearing Association Functional Assessment of Communication Skills for Adults (ASHA-FACS) and the Frenchay Aphasia Screening Test (FAST) and HRQL with the Stroke and Aphasia Quality of Life (SAQOL) scale (proxy-reported). SAQOL-39 scores were derived from the SAQOL. RESULTS & RESULTS: People with severe aphasia's quality of life, as measured by their proxies (n = 12), was low and more than one standard deviation below that of the standardization sample of the SAQOL. The overall mean score for the SAQOL-39 and the means for its physical and communication domains were below the 20th centile. They were also significantly lower that those of the comparison studies of self-reports (n = 83) and proxy ratings (n = 50) of people with mild or moderate aphasia (p<or=0.003). In the comparison studies there were no significant differences between the self-report and proxy ratings of people with mild or moderate aphasia. CONCLUSIONS & IMPLICATIONS This small study suggests that the HRQL of people with severe aphasia, as reported by their proxies, is severely compromised. Further research, using a wide range of methodologies, is needed in order to address the challenge of understanding better the quality of life of people with severe aphasia.
Evaluation of speech and language therapy interventions for pre-school children with specific language impairment: a comparison of outcomes following specialist intensive, nursery-based and no intervention.

BACKGROUND Clinical services in the UK are increasingly delivering 'consultative' methods of intervention rather than 'direct' intensive input for children with receptive and expressive language difficulties, yet there has been little systematic evaluation of these different intervention models. AIMS To investigate the effectiveness of different models of therapy provision for children with specific language impairment between the ages of 4;00 and 4;06 years. METHODS & PROCEDURES Twenty-four children were selected from a specialist waiting list in the London Borough of Lambeth. They were assessed on a range of verbal and non-verbal skills, and randomly assigned to three different intervention groups. Group 1 received direct intensive speech and language therapy weekly over an 8-month period at a child development centre; Group 2 received a nursery-based model of intervention; and Group 3 received review sessions at their local clinic. OUTCOME & RESULTS Statistical analysis before the intervention phase revealed no significant differences in scores between the three groups on a range of clinical and parental measures of language, non-verbal skills, play and behaviour. At the end of the intervention period the Intensive group showed significantly greater improvement than the No Intervention group on all clinical and parental measures, and significantly greater improvement than the Nursery-based group on all clinical and parental measures except for expressive grammar. CONCLUSIONS & IMPLICATIONS The results of this small-scale study demonstrate that intensive direct speech and language therapy delivered by speech and language therapists was a more effective model of intervention for this clinical group with severe speech and language impairment.
Cancer in patients with ulcerative colitis, Crohn's disease and coeliac disease: record linkage study

Objective The objective of this study was to determine the risk of cancers in cohorts of patients with ulcerative colitis, Crohn's disease, or coeliac disease, compared with the risk in a control cohort. Method The method used was the analysis of a linked statistical database of hospital and mortality data in an area in southern England. Results Rate ratios for cancer (excluding cases occurring within the first year of follow-up), compared with the value of 1 in the control cohort, were 1.25 [95% confidence interval (CI), 1.13–1.39] in patients with ulcerative colitis, 1.27 (95% CI, 1.11–1.45) with Crohn's disease, and 1.16 (95% CI, 0.94–1.43) with coeliac disease. In patients with ulcerative colitis or Crohn's disease, there was a significantly high risk of cancer of the colon [2.22 (95% CI, 1.71–2.83) and 1.64 (95% CI, 1.09–2.39), respectively]. In patients with ulcerative colitis there was a significantly high risk of cancer of the rectum [1.84 (95% CI, 1.27–2.58)]. In patients with ulcerative colitis or Crohn's disease, who did not undergo partial or total colectomy for it, the rate ratios for colon cancer were, respectively, 5.52 (95% CI, 4.39–6.71) and 4.81 (95% CI, 3.52–6.47). In ulcerative colitis, there was an elevated risk of cancer of the rectum, liver and ovary. The rate ratio for lung cancer was low, but of borderline significance [0.72 (95% CI, 0.50–0.98)]. In Crohn's disease, the rate ratio was high for cancer of the cervix [2.63 (95% CI, 1.12–5.29)]. In patients with coeliac disease, the high-risk cancer was non-Hodgkin's lymphoma [rate ratio 3.28 (95% CI, 1.49–6.28)]. Conclusion All three diseases carry an increased risk of cancer overall when the first year cases are included, though fairly modest in scale, and the increased risk seen in coeliac disease reduces when first year cases are excluded. Each has a distinctive pattern of individual high-risk cancers.
Increased prevalence of premature ejaculation in men with metabolic syndrome

Abstract This prospective study aimed to investigate the relationship between metabolic syndrome (Met S) and premature ejaculation (PE) among men. The study included 300 consecutive male patients (53.6 y ± 8.7) who attended the urology clinic (December 2013–September 2014), mostly complaining of renal/ureteric calculi. A diagnostic approach was undertaken to include demographics, clinical features and laboratory investigations of the study subjects. Both erectile function and PE were evaluated using the International Index of Erectile Function (abridged form, IIEF-5) and Premature Ejaculation Diagnostic Tool (PEDT) questionnaires, respectively. Results identified 182 (60.7%) men had Met S. Prevalence of PE was significantly higher in the subjects with Met S than the controls (35.2% vs 7.6%, p < 0.001). Patients with Met S and PE had significantly higher PEDT scores (15.4 vs 6.7), smaller waist circumference (108.3 cm vs 111.5 cm) and higher fasting blood sugar (187 mg% vs 161 mg%) than those with no PE (p < 0.001, 0.047 and 0.019, respectively). The other variables including IIEF-5 score, body mass index, serum triglycerides and high-density lipoprotein (14.98 vs 16.8, 30.6 vs 31.5, 192.9 mg% vs 178.1 mg% and 37.4 mg% vs 36.2 mg%, respectively) did not reveal significant differences. Both systolic hypertension and erectile dysfunction (ED) had significant associations (p = 0.047 and <0.001, respectively) with PE in Met S. In conclusion, PE has a high prevalence in Met S. Patients with Met S should be questioned about PE. Both ED and systolic hypertension may be associated with PE. Prevention of Met S should be considered, and this may be of help to decrease the prevalence of PE.
Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease

Aims To report the natural history of autochthonous hepatitis E and hepatitis E virus (HEV) IgG seroprevalence in Southwest England. Methods Patients with unexplained hepatitis were tested for hepatitis E and cases followed until recovery or death. Five hundred blood donors, 336 individuals over the age of 60 years and 126 patients with chronic liver disease were tested for HEV IgG. Results Forty cases of autochthonous hepatitis E (genotype 3) were identified. Hepatitis E was anicteric in 25% of cases and usually caused a self-limiting hepatitis predominantly in elderly Caucasian males. Six of 40 had a significant complication and three patients died, two of who had previously undiagnosed cirrhosis. Hepatitis E shows a seasonal variation with peaks in the spring and summer and no cases in November and December. HEV IgG prevalence increases with age, is more common in men and is 16% in blood donors, 13% in patients with chronic liver disease and 25% in individuals over 60 years. Conclusion Autochthonous hepatitis E is more common than previously recognized, and should be considered in the differential diagnosis in patients with hepatitis, whatever their age or travel history. It carries a significant morbidity and when seen in the context of chronic liver disease carries an adverse prognosis.
Executive functions deficits impair extinction of generalization of fear of movement‐related pain

Generalization of fear of movement‐related pain across novel but similar movements can lead to fear responses to movements that are actually not associated with pain. The peak‐shift effect describes a phenomenon whereby particular novel movements elicit even greater fear responses than the original pain‐provoking movement (CS+), because they represent a more extreme version of the CS+. There is great variance in the propensity to generalize as well as the speed of extinction learning when these novel movements are not followed by pain. It can be argued that this variance may be associated with executive function capacity, as individuals may be unable to intentionally inhibit fear responses. This study examined whether executive function capacity contributes to generalization and extinction of generalization as well as peak‐shift of conditioned fear of movement‐related pain and expectancy.
POSTURAL HYPOTENSION: A DISEASE OF THE SYMPATHETIC NERVOUS SYSTEM

Man would have syncope while standing upright if it were not for certain adaptive mechanisms which tend to maintain a constant cerebral blood flow. In the standing position the amount of blood present in the upper part of the body is decreased, first, because the vascular bed in the portion of the body below the heart is dilated by a high hydrostatic pressure1and, second, because the high capillary pressure causes an increased filtration of fluid from the blood stream and a decrease in plasma volume.2This decrease in blood volume in the upper part of the body is compensated for by vasoconstriction and by increase in heart rate. In a group of subjects first described by Bradbury and Eggleston3in a discussion of postural hypotension, these reactions failed to compensate for the pooling of blood and there was a striking fall in arterial pressure when the