Miracle-dz/UniFAR-FTUs huggingface dataset:
Professionalism, Sense of Community and Reason to Learn: Lessons from an Exemplary Career and Technical Education Center.

With current focus on academic proficiency, career and technical education (CTE) programs have received less emphasis as an alternative to traditional high school curricular experiences. Yet, this study found that when compared to peers in general high school settings, students in one rural CTE high school center perceived significantly more appeal, challenge, choices, meaningfulness and self-efficacy in their classrooms. Thus, an extensive qualitative study provided insights into this environment that distinguished it from more traditional secondary school settings. Themes of professionalism, sense of community, and reason to learn emerged in data analyses. Results offer methods that secondary educators can use to engage students in meaningful, challenging learning. Further, data revealed the experiences of students in this center’s CTE programs. Findings led to the conclusion that efforts to leave no children behind should include CTE as part of the continuum of educational
City Managers’ Job Satisfaction and Frustration

As an organizational objective and social value, job satisfaction is important in itself. Various studies have investigated job satisfaction of government employees at the federal, state, and local government levels. This study focuses on job satisfaction of city managers. In particular, it develops Herzberg’s motivator-hygiene theory in the context of local government to identify distinct sets of motivators and hygiene factors for city managers. Using survey data collected from city managers in Georgia, this study suggests that performance of city government and managers’ community influence are important motivators for city managers. Salary and city population are hygiene factors, whereas managers’ policy-making influence, relationship with the council, and effectiveness of council exert significant impact on both satisfaction and frustration. Implications and suggestions are provided.
Mutants of plant genes for developing cancer vaccines

Preventive Human Papillomavirus (HPV) vaccination is an expensive practice and it may be an insufficient tool to tackle cervical cancer worldwide. Therapeutic intervention is seeking for safe/effective vaccines inducing the activation of CD8+ cytotoxic T lymphocytes (CTLs) that is required to clear the tumor. Linking a tumor-specific antigen (i.e. the E7 oncoprotein of the ‘high risk’ HPVs) to molecules able to increase its immune ‘visibility’ represents a strategy to force the immune system to fight cancer. We focused on plants as sources of innovative immunostimulatory sequences. We have already shown the anti-cancer activity obtained by fusing E7GGG (a mutagenized E7 gene from the high risk HPV type 16) to the coat protein of a plant virus, the Potato Virus X. We are now investigating plant-derived carriers, such as the ‘Ribosome inactivating proteins’ (RIPs), so far used to develop immunotoxins for targeted cancer therapy. Beside toxicity, RIPs have other features (i.e. immunogenicity, ability to modulate immune functions and apoptosis induction) that could be useful tools to use in tumor immunotherapy. A non toxic mutant of saporin (SAP-KQ) was used as a carrier for the E7GGG gene in the context of a DNA-based vaccine. We show here that fusion constructs of SAP-KQ with E7GGG can induce E7-specific Immunoglobulins (IgGs), CTLs and Delayed-Type Hypersensitivity (DTH) affecting the growth of E7-expressing tumors in mice. These data demonstrate that mutant plant genes hold promise to improve the poor immunogenicity of tumor-associated cancer antigens and could contribute to the evolution of new cancer immunotherapy.
Estimating the Cost of Executive Stock Options: Evidence from Switzerland

It is often argued that Black-Scholes (1973) values overstate the subjective NEWLINE value of stock options granted to risk-averse and under-diversified executives. NEWLINE We construct a “representative” Swiss executive and extend the certainty- NEWLINE equivalence approach presented by Hall and Murphy (2002) to assess NEWLINE the value-cost wedge of executive stock options. Even with low coefficients NEWLINE of relative risk aversion, the discount can be above 50% compared to the NEWLINE Black-Scholes values. Regression analysis reveals that the equilibrium level NEWLINE of executive compensation is explained by economic determinant variables NEWLINE such as firm size and growth opportunities, whereas the managers’ pay-forperformance NEWLINE sensitivity remains largely unexplained. Firms with larger NEWLINE boards of directors pay higher wages, indicating potentially unresolved NEWLINE agency conflicts. We reject the hypothesis that cross-sectional differences in NEWLINE the amount of executive pay vanish when risk-adjusted values are used as NEWLINE the dependent variable.
Value Relevance of Mandated Comprehensive Income Disclosures

This study provides some market based evidence on the usefulness of comprehensive income disclosures in a Statement of Changes in Equity (SCE). Using a sample of listed New Zealand firms, we find no evidence that separate disclosure of the comprehensive income items provides any value relevant information above and beyond the aggregate comprehensive income figure. Likewise, in the post-SCE period, we find no evidence of an increase in the incremental value relevance of the comprehensive income items over net income. While our results are sensitive to outliers, they suggest that standards requiring disclosure of a SCE may not be necessary. Copyright Blackwell Publishers Ltd 2000.
An empirical study of collaborative partnering among enterprises and government organizations for information system outsourcing

Most researches on information systems (IS) outsourcing indicate that public sector decides to outsource information technology (IT) services due to the belief that private vendors offer more cost advantages. This research explores government sectors of outsourcing and focus on the role of relationship for IS-service providers. Quantitative data of 126 questionnaires and 30 IS demonstrate that trust, mutual dependence, equipment investment and information sharing are contributing factors to successful outsourcing long-term partnerships. Information sharing between the service receiver and provider is also vital in terms of equipment investment in long-term partnerships, and is affected by the level of trust that each party holds for the other within the outsourcing process. Conceptual model is useful in explicating important government-business partnering strategies – the model highlights not only the economic benefits that the IS-outsourcing relationship brings based on social exchange theory characteristics, but also suggests many additional relevant elements.
Prediction of Dna-binding Residues from Sequence Features

Protein-DNA interaction plays a pivotal role in transcriptional regulation, DNA metabolism and chromatin formation. Although structural data are available for a few hundreds of protein-DNA complexes, the molecular recognition pattern is still poorly understood. With the rapid accumulation of sequence data from many genomes, it is important to develop predictive methods for identification of potential DNA-binding residues in proteins. In this study, neural networks have been trained using five sequence-derived features for prediction of DNA-binding residues. These features include the molecular mass, hydrophobicity index, side chain pKa value, solvent accessible surface area and conservation score of an amino acid. Interestingly, the side chain pKa value appears to be the best feature for prediction, suggesting that the ionization state of amino acid side chains is important for DNA-binding. The predictive performance is enhanced by using multiple features for classifier construction. The classifier that has been constructed using all the five features predicts at 72.71% sensitivity and 67.73% specificity. This is by far the most accurate classifier reported for prediction of DNA-binding residues from sequence data. The classifier has also been evaluated by using the Receiver Operating Characteristic curve and by examining the predictions made for different classes of DNA-binding proteins. Supplementary materials including the datasets are available at http://bioinformatics.ksu. edu/pdi/feature.html.
Gender Differences in Days Lost from Work Due to Illness

The author uses data from the 1987 National Medical Expenditure Survey to investigate the extent and determinants of gender differences in days lost from work due to illness. She finds that for both men and women, health status measures, such as self-reported health status and medical events, more consistently explained absenteeism than did economic factors such as wages and the presence of sick leave. The presence of young children increased women's, but not men's, probability of missing work, as well as women's number of absences for those who missed work in 1987. Among men who were absent from work in 1987, however, the presence of children in day care increased the number of days lost from work. In that regard, those men, most of whom were likely to be either single parents or married with a working wife, behaved more like mothers with young children than like other men.
Actions of A-131701, a novel, selective antagonist for alpha-1A compared with alpha-1B adrenoceptors on intraurethral and blood pressure responses in conscious dogs and a pharmacodynamic assessment of in vivo prostatic selectivity.

A-131701 (3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b, hexahydro-[1H]-benz[e]isoindol-2-yl)ethyl]pyrido [3',4': 4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione) is a novel compound previously shown to be selective for alpha-1a sites compared with alpha-1b adrenoceptors in radioligand binding studies and isolated tissue bioassays and to block canine urethral pressure (IUP) responses to exogenous alpha-1 adrenergic agonists to a greater extent than blood pressure responses. In conscious dogs in which IUP and mean arterial blood pressure (MABP) responses were measured periodically up to 24 hr, A-131701 blocked phenylephrine (PHE)-induced increases in IUP to a greater extent than MABP responses, and the blockade of the IUP effects of PHE was significantly different from control for up to 12 hr after doses greater than 0.3 mg/kg p.o. , whereas blood pressure effects were of a lesser extent and duration. In addition to the weak antagonism of PHE-induced blood pressure responses, A-131701 also exhibited minimal effects on basal blood pressure in the dog, unlike terazosin, doxazosin or tamsulosin. Pharmacokinetic analysis of plasma samples from dogs indicated that A-131701 had a half-life of 0.4 to 0.8 hr and a bioavailability of 30 to 50% in dogs. Somewhat longer half-lives were observed in rat and monkey, with bioavailability values in the 25 to 30% range. Evidence of nonlinearity of pharmacokinetics was obtained in dogs and monkeys. Pharmacodynamic analysis revealed differences between A-131701 and nonselective alpha-1 adrenoceptor antagonists in selectivity for prostatic versus vascular alpha-1 adrenoceptors based on either extent or duration of blockade, which were either similar to or superior to compounds such as tamsulosin or REC 15/2739. These data demonstrate that A-131701 selectively blocks canine prostatic alpha-1 adrenoceptors for prolonged periods compared with MABP responses in vivo. Therefore, A-131701 should have clinical utility in the pharmacotherapy of benign prostatic hyperplasia.
Reframing Social Entrepreneurship Impact: Productive, Unproductive and Destructive Outputs and Outcomes of the Milwaukee School Voucher Programme

Abstract This paper initially seeks to problematize the common assumption that all social entrepreneurship impact is positive. No matter what social entrepreneurs and other powerful intermediaries subjectively believe or hope, assuming that social entrepreneurship is always productive a priori imposes significant limits on this budding field. In order to overcome this bias it is necessary to reframe how we approach and assess social entrepreneurship impact. Drawing from the economic entrepreneurship literature, this paper outlines a multi-dimensional framework to serve as a useful and preferable starting point for assessing social entrepreneurship. We then make use of this multi-dimensional lens to look closer at the impact of one case of social entrepreneurship, the school voucher programme in Milwaukee.
Conceptual Framework of Antecedents to Trends on Permanent Magnet Synchronous Generators for Wind Energy Conversion System

The Wind Energy Conversion System (WECS) plays an inevitable role across the world. In particular, the attention for Permanent Magnet Synchronous Generators (PMSGs) connected with wind farm is popular. This paper deals with the literature review that describes the recent advances, progresses and innovatory trends on PMSGs for WECS. Comparison between geared and direct-driven conversion systems and the classification of electrical machines used in WECS are discussed. A detailed analysis on the design aspects considering various topologies of PMSGs are encompassed in the literature. The PMSG design and optimization problems are solved by field computation techniques and optimized by using Soft Computing (SC) techniques . The threedimensional, finite element software platform for the analysis and design of PMSGs is discussed. This paper also deals with the interdisciplinary modeling, analysis, and optimization of PMSG using Finite Element Analysis (FEM) and SC techniques. Finally, PMSGs are reviewed and compared for further exploration.
The incidence of hypertension in insulin-dependent diabetes.

BACKGROUND There are few epidemiologic data describing the long-term incidence of hypertension in people with diabetes. METHODS In a population-based study performed in southern Wisconsin, 765 individuals diagnosed as having diabetes when they were younger than 30 years and taking insulin participated in baseline, 4-year, and 10-year examinations. Blood pressure was measured by standardized protocols,and hypertension was defined as a mean systolic blood pressure of 160 mm Hg or more ( > or = 140 mm Hg in those younger than 25 years) and/or mean diastolic blood pressure of 95 mm Hg or more ( > or = 90 mm Hg in those younger than 25 years) and/or history of hypertension with the use of antihypertensive medication. RESULTS The prevalence of hypertension at baseline was 17.3%. The 10-year incidence of hypertension was 25.9%. The incidence of hypertension was greater with older age, longer duration of diabetes, higher glycosylated hemoglobin level, proteinuria, more severe retinopathy, and male gender. After other risk factors were controlled for, the 10-year incidence of hypertension was significantly related to higher glycosylated hemoglobin level (odds ratio, 1.23 per percentage increase; 95% confidence interval, 1.13 to 1.34) presence of gross proteinuria (odds ratio, 3.64; 95% confidence interval, 2.26 to 5.85), longer duration of diabetes (odds ratio, 1.03 per year of diabetes; 95% confidence interval, 1.01 to 1.04), and being male (odds ratio, 1.93; 95% confidence interval, 1.34 to 2.77). CONCLUSION These data suggest that control of hyperglycemia and prevention of gross proteinuria may lead to a reduction in the long-term incidence of hypertension.
Etiologies of Parkinsonism in a Century‐Long Autopsy‐Based Cohort

We investigated the distribution of different etiologies underlying Parkinsonism in a hospital‐based autopsy collection, studied the demographic data and evaluated diagnostic accuracy using histopathological examination as the gold standard. Out of a total of 9359 consecutive autopsy cases collected between 1914 and 2010, we identified 261 individuals who carried a clinical diagnosis of a Parkinsonian syndrome at death. A detailed neuropathological examination revealed idiopathic Parkinson's disease (PD) in 62.2%, progressive supranuclear palsy (PSP) in 4.2%, multiple system atrophy (MSA) in 2.3%, corticobasal degeneration (CBD) in 1.2%, postencephalitic Parkinsonism (PEP) in 2.7%, vascular Parkinsonism (VaP) in 8.8% and Alzheimer‐type pathology (ATP) of the substantia nigra in 8%. The diagnostic accuracy of PD in our cohort was lower (71.2%) than those reported in previous studies, although it tended to increase during the last decades up to 85.7%. Of particular interest, we found that PD, while being the most frequent cause of Parkinsonism, was greatly overdiagnosed, with VaP and ATP being the most frequent confounding conditions.
Vascular pathology in Alzheimer's disease

Histopathologically, numerous senile plaques and neurofibrillary tangles were remarkably observed in the brain with Alzheimer's disease. At the same time, so much simple atrophy of nerve cells was evident under light microscopy. Electron microscopical observations of serial sections revealed that small blood vessels, including capillaries, had a deep relationship to the amyloid fibrils which formed the senile plaques and they had fallen into degenerative states. The vascular feet of the astroglial cells surrounding small blood vessels showed degenerative features, and many nerve cells in this area either showed various degrees of degeneration or apparently were destroyed. The atrophy of the brain with Alzheimer's disease is considered to be caused by the amyloid angiopathy of small blood vessels and the degeneration of capillaries and vascular feet. These findings strongly suggest that the major causal mechanism of Alzheimer's disease is an alteration of the blood–brain barrier. Morphology is an expression of both the structure and the function of organs in the living body. Based on this viewpoint, this review article emphasizes that the morphological changes to small blood vessels in the brain with Alzheimer's disease convey crucial information and clues for solving the underlying mechanism that causes the disease.
Auditor Industry Specialization, Client Bargaining Power, and Audit Pricing

Porter's (1985) analysis of competitive strategy is used to explain industry specialization by Big 6 accounting firms. In Porter's framework, industry specialization can be viewed as a differentiation strategy whose purpose is to create a sustainable competitive advantage relative to nonspecialist auditors. A differentiation strategy will lead to higher audit fees if valued by clients. We find evidence of higher fees for Big 6 industry specialists relative to nonspecialists in the U.S. audit market, but only for companies in the lower half of the sample based on size (assets <$123 million). By contrast, companies in the upper half of the sample do not pay a specialist premium, and audit fees actually decrease as a company becomes increasingly large relative to its auditor's industry clientele. Together these results suggest that audit fees are higher when clients are small and have little bargaining power, but audit fees are lower when clients have greater bargaining power and this is more likely when com.
The Distribution of Welfare Gains from Price Stabilization: The Case of Multiplicative Disturbances

WITH THE UNCERTAINTIES due to the current inflationary conditions, the desirability of price stabilization has once again become a topical issue in the area of public economic policy. It is a subject with a long history, much of the discussion originating with Waugh [17]. In that paper he established the proposition that consumers having a fixed downward sloping demand curve and facing random prices due to stochastic fluctuations in supply, are better off than if these prices are stabilized at their mean.2 Some years later, Oi [7] demonstrated a parallel result for firms. He showed that if they have an upward slopingsu pply curve and face random selling prices due to stochastic shifts in demand, then they too, will lose from having prices stabilized at their mean.3 These two analyses considered the welfare of one group only, ignoring the effects the price stabilization scheme may have on the other. The first author to recognize this was Massell [5] who integrated these two contributions into a single framework. Assuming linear demand and supply curves and additive stochastic disturbances he showed: ( i ) Producers lose (gain) from price stabilization if the source of price instability is random shifts in demand (supply); (ii) consumers lose (gain) from price stabilization if the source of price instability is random shifts in supply (demand); (iii) where both demand and supply are random, the gains to each group are indeterminate and depend upon the relative sizes of the variances and upon the slopes of the demand and supply curves; (iv) provided neither the demand curve nor the supply curve is perfectly elastic, the total gains from stabilization are always positive, with the gainers being able in principle, to compensate the losers. With infinitely elastic functions, all gains tend to zero. While Massell's analysis has the advantage that the expressions measuring the welfare gains from stabilization can be calculated explicitly, linearity is nevertheless, a restrictive assumption. Much relevant empirical work finds non-linear relationships, such as log-linear functions, to be superior, in which case the
Bone marrow transplantation for adult poor prognosis lymphoblastic lymphoma in first complete remission

Summary. Twenty‐five adult patients, 19 males, six females, age 16–43 years (median 23), with lymphoblastic lymphoma received allogeneic or autologous bone marrow transplantation in first complete remission. Twelve patients were Murphy stage IV with bone marrow and/or CNS involvement and 13 were stage III of whom nine had thoracic involvement. Complete remission was achieved with an intensive anthracycline containing multiagent chemotherapy protocol. Twelve patients with an HLA identical sibling received an allogeneic marrow and 13 without a donor received their own marrow harvested a median of 2 months (0–4 months) after complete remission and purged in vitro with either mafosfamide (eight patients) or anti T‐cell monoclonal antibodies and complement (three patients). Bone marrow transplantation was performed 1–7 months (median 3 months) after achieving first complete remission. The conditioning regimen consisted of cyclophosphamide or high dose melphalan and total body irradiation. The actuarial 4‐year disease‐free survival is 68% (±9% SE). The actuarial probability of relapse was 26% (±3% SE) with a median follow up to 22 months. There was no difference between allogeneic and autologous transplantation with eight out of 12 allo patients in first continuous complete remission 26–45 months after transplant and nine out of 13 auto in continuous complete remission 15–75 months after transplant. These results compare favourably with those achieved with the best chemotherapeutic regimen used for such patients.
The Effects of Political Institutions on Women’s Political Representation

Women’s political representation exhibits substantial cross-national variation. While mechanisms shaping these variations are well understood for Western democracies, there is little consensus on how these same factors operate in less developed countries. Effects of two political institutions—electoral systems and gender quotas—are tested across 168 countries from 1992 to 2010. Findings indicate that key causal factors interact with a country’s socioeconomic development, shifting their importance and possibly even direction at various development thresholds. Generalizing broadly across countries, therefore, does not adequately represent the effects of these political institutions. Rather, different institutional changes are advised to increase women’s presence in national governments.