Miracle-dz/UniFAR-FTUs huggingface dataset:
TRK1 and TRK2 encode structurally related K+ transporters in Saccharomyces cerevisiae

We describe the cloning and molecular analysis of TRK2, the gene likely to encode the low-affinity K+ transporter in Saccharomyces cerevisiae. TRK2 encodes a protein of 889 amino acids containing 12 putative membrane-spanning domains (M1 through M12), with a large hydrophilic region between M3 and M4. These structural features closely resemble those contained in TRK1, the high-affinity K+ transporter. TRK2 shares 55% amino acid sequence identity with TRK1. The putative membrane-spanning domains of TRK1 and TRK2 share the highest sequence conservation, while the large hydrophilic regions between M3 and M4 exhibit the greatest divergence. The different affinities of TRK1 trk2 delta cells and trk1 delta TRK2 cells for K+ underscore the functional independence of the high- and low-affinity transporters. TRK2 is nonessential in TRK1 or trk1 delta haploid cells. The viability of cells containing null mutations in both TRK1 and TRK2 reveals the existence of an additional, functionally independent potassium transporter(s). Cells deleted for both TRK1 and TRK2 are hypersensitive to low pH; they are severely limited in their ability to take up K+, particularly when faced with a large inward-facing H+ gradient, indicating that the K+ transporter(s) that remains in trk1 delta trk2 delta cells functions differently than those of the TRK class.
Physiological response to moderate exercise workloads in a pulmonary rehabilitation program in patients with varying degrees of airflow obstruction.

STUDY OBJECTIVES To investigate whether a 12-week pulmonary rehabilitation program that includes moderately intensive exercise training performed twice weekly can induce a training effect in patients with a wide variation of airflow limitation. PARTICIPANTS Sixty patients with COPD (38 men) with a mean +/- SD FEV(1) % predicted of 55.1 +/- 19.8 (range, 0.51 to 2.99). All patients performed identical incremental symptom-limited cycle ergometer testing before and after a 12-week study period. MEASUREMENTS AND RESULTS After 12 weeks, the patients demonstrated a significant (p < 0.05) increase in the peak values for work rate (WR; 77 +/- 30 vs 91 +/- 36 W) and oxygen uptake (1.14 +/- 0.45 vs 1.20 +/- 0.52 L/min). Furthermore, at a given WR during incremental symptom-limited cycle ergometer testing, there were significant (p < 0.05) reductions in minute ventilation (42.4 +/- 16.1 vs 37.0 +/- 13. 6 L/min), carbon dioxide output (1.13 +/- 0.49 vs 1.03 +/- 0.42 L/min), ventilatory equivalent for oxygen (37.6 +/- 8.1 vs 36.0 +/- 6.3), and heart rate (135 +/- 15 vs 128 +/- 16 beats/min). None of the observed physiologic changes correlated with FEV(1) % predicted. CONCLUSIONS A pulmonary rehabilitation program performed twice weekly with moderate exercise workloads can lead to a physiologic training response irrespective of the degree of airflow limitation.
Assessing the influence of customer relationship management (CRM) dimensions on organization performance

Purpose – The purpose of this paper is to investigate the relationship between CRM dimensions (i.e. customer orientation, CRM organization, knowledge management, and technology based CRM) and various aspects of organization performance (i.e. financial, customer, internal process, and learning and growth) in Malaysian hotels.Design/methodology/approach – This is a quantitative study, the response came from the managers of 152 Malaysian hotels (3 to 5 star) and data collected was subjected to correlation and regression analysis in pursuance of the study's stated objectives.Findings – The results of this study suggest that all dimensions of CRM (i.e. customer orientation, CRM organization, knowledge management and technology based CRM) have a positive and significant impact on different perspectives of hotel performance. However, CRM technology failed to show a significant relationship with learning and growth perspective of hotel performance.Research limitations/implications – An emphasis has been placed on.
Output Dead-Time in Point Processes

When events of temporal point processes are too close to each other they can be erased by dead-time effects. Among various possible mechanisms of dead-time, the output dead-time is the most important. Dead-time effects modify the statistical properties of point processes and some of these modifications are analyzed in this article. To do so, we note that a point process is defined by the distance between its successive points called life-time which constitutes a discrete time positive signal. The dead-time mechanism is a system which transforms such a signal into another discrete time positive signal. Except in very specific cases this transformation cannot be expressed in closed form. We show, however, that it can be written in a recursive form analogous to the state representation of systems. By using this recursion, various statistical properties of point processes with dead-time are analyzed in computer experiments. In this study, we focus on the probability distribution of the intervals between points and the coincidence function which describes the second-order properties of the point process. For the rare processes where theoretical calculations are possible there is an excellent agreement between experiment and theory.
Are Cross-Border Acquisitions Different from Domestic Acquisitions? Evidence on Stock and Operating Performance for U.S. Acquirers

We provide empirical evidence on how cross-border acquisitions from the perspective of an U.S. acquirer differ from domestic transactions, based on stock and operating performance measures. The distinction between domestic and cross-border acquisitions is a function of the change in market integration, which shifts the balance between the relative costs and benefits of cross-border versus domestic acquisitions. Furthermore, recent evidence on the costs of global diversification suggests another reason for a distinction between cross-border and domestic acquisitions. For a sample of 4,430 acquisitions between 1985 and 1995 and controlling for various factors we find that U.S. acquirers experience significantly lower stock and operating performance for cross-border than for domestic transactions. Stock returns are negatively associated with an increase in both global and industrial diversification. Cross-border takeover activity has increased during the past decade and the observed difference in bidder gains is more pronounced for the latter half of the sample period. With the exception of the U.K., bidder returns are negatively related to the target country's degree of economic restrictiveness. Lower bidder gains for cross-border transactions are consistent with the acquirer's inability to correctly value or capture synergies in cross-border takeovers.
Possible association of body dysmorphic disorder with an occupation or education in art and design.

OBJECTIVE The authors hypothesized that because patients with body dysmorphic disorder are preoccupied with their appearance and aesthetics, they are more likely to have an occupation or education in art and design than patients with other psychiatric disorders. METHOD Information on occupation and higher education or training was extracted from the case notes of 100 consecutive patients with body dysmorphic disorder and compared with the same information for 100 patients with a major depressive episode, 100 with obsessive-compulsive disorder (OCD), and 100 with posttraumatic stress disorder (PTSD). RESULTS Twenty percent of the patients with body dysmorphic disorder had an occupation or education in art or design, compared with 4% of the patients with major depressive episode, 3% of those with OCD, and 0% of those with PTSD. CONCLUSIONS Onset of body dysmorphic disorder is usually gradual during adolescence, and an education in art and design may be a contributory factor to its development in some patients. An equally plausible explanation is that patients with body dysmorphic disorder tend to have an interest in aesthetics.
ANALISIS PENGARUH AUDIT TENURE, UKURAN KAP DAN DIVERSIFIKASI GEOGRAFIS TERHADAP MANAJEMEN LABA

This study aims to examine the influence of audit tenure, audit firm size and geographic diversification towards earnings management in manufacturing compnies. Audit tenure is measured by the amount of the year of work relationship between auditee and the last public accountant firm. Audit firm size is measured by dummy variabel. The Audit firm is divided into audit firms that affiliated with big four and non big four audit firms. And geographic diversification is measured by the number of firms geographic segments. The population of this study are the manufacturing companies that listed in Indonesia Stock Exchange (BEI) in 2012. Purposive sampling is used for sampling method. And multiple regression technique is used for the data analysis. The total number of samples for this study are 94 companies. But, there are found 16 samples as outlier should be excluded from sample observation. So, the final samples for this study are 78 companies. The result of this study indicates that audit tenure have positif significant influence in earnings management, audit firm size have negative significant influence in earnings management. Meanwhile, geographic diversification don’t have significant influence to earnings management.
THE HIGH-VOLUME RETURN PREMIUM

The objective of this paper is to investigate the role of trading activity in terms of the information it contains about future return. More precisely, we are interested in the power of trading volume in predicting the direction of future return movements. We find that individual stock whose trading activity is unusually large (small) over periods, as measured by trading volume during those periods; tend to experience large (small) returns over the subsequent period. In other words, a high-volume return premium were combined effect between stocks experiencing positive shocks subsequent generate positive abnormal return, where as stock experiencing negative volume shocks subsequently negative abnormal return. Abstract in Bahasa Indonesia : Tujuan dari penelitian ini untuk mengetahui bahwa aktivitas perdagangan yang sangat tinggi akan diikuti oleh return yang positif pada periode berikutnya dan aktivitas perdagangan yang sangat rendah akan diikuti oleh return yang negatif pada periode berikutnya. Hasil dari penelitian ini ditemukan bahwa aktivitas perdagangan dapat digunakan untuk memprediksikan return yang akan datang, aktivitas perdagangan yang sangat tinggi pada perusahaan dengan nilai kapitalisasi besar dan perusahaan dengan nilai kapitalisasi kecil akan diikuti oleh return yang positif pada periode berikutnya, dan aktivitas perdagangan yang sangat rendah pada perusahaan dengan nilai kapitalisasi besar dan perusahaan dengan nilai kapitalisasi kecil akan diikuti oleh return yang negatif pada periode berikutnya. Kata kunci : aktivitas perdagangan, return yang positif, return yang negatif
Single-chip 5.8 GHz ETC transceiver IC with PLL and demodulation circuits using SiGe HBT/CMOS

A single-chip 5.8 GHz ETC transceiver IC with PLL and demodulator uses SiGe HBT/CMOS. The fully integrated ETC chip includes a 31 dB-gain RX stage, an ASK demodulator, and a high-precision RSSI. The PLL is constructed with a varactor-tuned LC-VCO and a low-power BiCMOS synthesizer. The TX stage incorporates a transformer-transferred single-ended PA.
The Relationship between Internationalization and Firm Performance

Title: The Relationship between Internationalization and Firm Performance Seminar date: 5 June, 2008 Course: Masters thesis in Business Administration, Programme for Managing People, Knowledge and Change, 15 University Credit Points (15 ECTS). Authors: Cheng Hsun Chiang and Marton Pap Advisor: Dan Karreman Key words: Internationalization, Performance, Multinationality, Degree of Internationalization (DOI), Country of Origin Purpose: To illuminate various crucial aspects of internationalization by systematically contrasting the different models of the multinationality-performance relationship and searching for underlying reasons. Methodology: Meta-analysis on previous theoretical and empirical research. Our emphasis in this paper has been put on the qualitative aspects of the previous research unlike many other conventional meta-analyses that focus on the comparison of the empirical data. Theoretical perspectives: Five main models have been developed by earlier studies to describe the relationship between internationalization and performance: positive linear, no or ambiguous relation, inverted U-shaped, standard U-shaped and S-shaped curve. In this paper, we have identified six areas that reveal valuable learning points about multinationality and performance: the conceptualization and measurement of internationalization and corporate performance, the control variables applied in the research, the investigated time period, the country of origin and the relation with product diversification. Empirical foundation: We have not conducted an empirical research. Instead, we have synthesised the empirical studies of 13 articles. Conclusions: There is no generally applicable model to describe the relationship between internationalization and performance. There are a number of factors that influence this relationship and each company has an idiosyncratic position in the matrix of the factors. Knowing these factors can help managers in the strategic planning of the international development of their companies.
On the Determinants of Corporate Cash Holdings in Japan: Evidence from Panel Analysis of Listed Companies [in Japanese]

Exploiting dramatic changes in individual corporate behavior as well as macroeconomic environment for the period between 1982 and 2005, this paper empirically investigates the determinants of corporate cash holdings using the panel data of the companies listed at the three major stock exchanges. We find that like in Pinkowitz and Williamson (2001), the rent extraction by banks over industry firms promoted corporate cash holdings in the early 1980s. However, the weakened bank power was not responsible for a drastic decrease in the cash/asset ratio observed during the first half of the 1990s. Instead, the ratio declined as a consequence of the contraction of investment opportunities, the buildup of business credits as an alternative financial instrument, less needs for dividend payments, and higher costs of cash holdings.
CLASSIFYING HEARTRATE BY CHANGE DETECTION AND WAVELET METHODS FOR EMERGENCY PHYSICIANS

Heart Rate Variability (HRV) carries a wealth of information about the physiological state and the behaviour of a living individual. Indeed, the heart rate variation is intrinsically linked to the autonomic nervous system: the parasympathetic and orthosympathetic systems. Thus, any imbalance in these two opposite systems results in a variation of the cardiac frequency modulation. This alter- nation between equilibrium and disequilibrium (frequency variability) is recognized as an indicator of well-being and good health. Particularly, decreased HRV is linked to stress, fatigue and decreased physical performance. The aim of this work is to exploit the heart rate signals to detect stressful situ- ations in dierent populations: emergency physicians, sportsmen, animal behaviours. We introduce a methodological framework for the detection of stress and eventually well-being. Our contribution is rstly based on using Gabor wavelets to extract energies corresponding to High and Low Frequency (HF and LF) bands which are linked to the parasympathetic and orthosympathetic systems. We then detect change points on these energies using the Filtered Derivative with p-value (FDpV) method. Fi- nally, we develop a typology of cardiac activity by distinguishing homogeneous groups or state proles sharing similar characteristics. We apply our methodology on a real dataset collected by monitoring cardiac activity of an emergency physician for 24 hours.
Service Strategies Marketing, Operations, and Human Resource Practices

Over the last three decades, the principles of service management have become widely accepted. These call for an integrated approach to marketing, operations, and human resource management (HRM). The scholarly and business press routinely point to the importance of customer loyalty and customer relationship management for corporate profitability. Advances in marketing concepts and information systems make it possible to capture more precisely the demand characteristics of customers and to tailor solutions to meet their needs. Why is it, then, that measures of customer satisfaction have declined steadily in the last decade, websites for consumer complaints have proliferated, and media accounts of bad service appear with regularity? In this chapter, I explore this paradox. I focus particularly on the private sector and on interactive service activities, defined as those that are produced through the interaction of employees and customers (Leidner 1993). Service management is important because the expansion of service activities and contraction of manufacturing in advanced economies means that management in services covers an ever increasing number and range of operations and employment. In addition, competing on the basis of customer service has become central to competitiveness in manufacturing as well as service industries. This is particularly true in supply chain management, where quality and productivity depends importantly on how vendor contracts with major customers are managed. However, it also applies to consumer markets, where after-sales service and service warranties and agreements have become a major source of revenues in goods production, particularly durable goods. Finally, there is growing empirical evidence that companies that compete on the basis of customer quality and customization do generate higher revenues and profits. Customer satisfaction does, in fact, matter; and the evidence is consistent with the widespread rhetoric of the importance of long-term customer relationships.
Exit from farming and land abandonment in Northern Norway

The combination of nature and farmed land is one reason why Northern Norway is attracting tourists. It is therefore of interest to know which farms that are more likely to quit faming, and to see what factors that are important for abandonment of farm land when the owner of the farm exits farming. Our results indicate that smaller properties in areas with few farmers are the most likely to be abandoned. Property structure is another important factor for abandonment, but is less important for the exit-decision. Size of the farm, including both rented and own farm land, appears to be more important for the exit-decision. Larger farm operations, with breeding stock, primary sheep and dairy cattle are more likely to continue farming.
Single nucleotide polymorphisms associated with metastatic tumour antigen 1 overexpression in patients with hepatocellular carcinoma

Metastatic tumour antigen 1 (MTA1) promotes angiogenesis by stabilizing hypoxia‐inducible factor‐1α (HIF‐1α), which is closely associated with frequent postoperative recurrence and poor survival in patients with HCC. In this study, we determined single nucleotide polymorphisms (SNPs) in angiogenesis‐related genes that are associated with MTA1 overexpression in HCC tissues.
What is a blood group antigen?

To the Editor: The correlation between the presence of antibodies to hepatitis C virus (anti-HCV) and antibodies to hepatitis B core antigen (anti-KBc) or increased alanine aminotransferase (ALT) level is reported to be low. ’*2 However, such comparisons were obtained by using first-generation enzyme-linked immunosorbent assays (ELISAs) and the c-100 antigen. We report our findings (Table 1) in 10,736 unselected consecutive volunteer blood donors screened by the second-generation ELISA (Ortho Diagnostic Systems, Raritan, NJ) and a four-antigen recombinant immunoblot assay (4-RIBA) (Chiron, Emeryville, CA). Seventy (0.6%) of 10,736 were repeatedly positive for antiHCV on ELISA. Of those 70 sera, 19 (27%) had a specimen absorbance-to-cutoff ratio less than 4. Seventeen of these 19 sera were negative on the 4-RIBA, 1 was positive (reactive to the c22-3 and c33c bands, ELISA ratio 3.8), and 1 was indeterminate (reactive to the c22-3 band only, ELISA ratio 1.7). Twenty-eight of the 51 samples with ELISA ratio higher than 4 were selected at random and were tested by 4-RIBA. Twentytwo (79%) of the 28 reacted (13 with 3 or 4 antigens, 9 only with Q3c and c22-3 antigens), and 6 (21%) were indeterminate (5 reactive to the c22-3 band, 1 to c33c). ALT levels were measured by spectrophotometry in optimized conditions at 37°C. The upper limit of normal was 39 IU per L. The mean ALT level was only significantly raised in the group with high ELISA ratio (>4): 35.5 f 21.5 IU versus 16.9 * 11.1 IU per L in normal blood donors ( p ~ l o ~ ) . Twenty-two (43.1%) of 51 sera had ALT levels >39 IU per L, compared with 3.5 percent in the normal population. The mean ALT level was also higher in 4-RIBA-positive sera (44.0 f 20.9 IU/L) than in 4-RIBA-indeterminate sera (15.1 f 14.3 IWL). Twelve (52%) of 23 4-RIBA-positive sera had ALT >39 IU per L, versus 1 (14%) of 7 4-RIBA-indeterminate sera (Fischer’s exact test, p = 0.079). Only 5 (9.8%) of 51 anti-HCV ELISA-positive blood donors with high ELISA ratio had anti-HBc (with raised ALT in 2 out of 5 cases), as compared with 2.1 percent in the normal population (p>0.3). These data suggest a low effectiveness of antiHBc screening for the prevention of non-A,non-B hepatitis in our population. Finally, about 50 percent of 4-RIBA-positive samples (a result that is closely associated with non-A,non-B hepatitis transmission)’ had raised ALT values. Moreover, since ALT screening may detect infective blood units during the delay between infection and seroconversion,* these results confirm the appropriateness of discarding blood units with ALT exceeding the upper limit of normal.
Partners or Strangers? Cooperation, Monetary Trade, and the Choice of Scale of Interaction

We show that monetary exchange facilitates the transition from small to large-scale economic interactions. In an experiment, subjects chose to play an “intertemporal cooperation game” either in partnerships or in groups of strangers where payoffs could be higher. Theoretically, a norm of mutual support is sufficient to maximize efficiency through large-scale cooperation. Empirically, absent a monetary system, participants were reluctant to interact on a large scale; and when they did, efficiency plummeted compared to partnerships because cooperation collapsed. This failure was reversed only when a stable monetary system endogenously emerged: the institution of money mitigated strategic uncertainty problems. (JEL C71, C73, E42)
ANALISIS PERBEDAAN KINERJA KEUANGAN BANK SYARIAH MURNI DENGAN BANK SYARIAH CAMPURAN PADA TAHUN 2011 DENGAN MENGGUNAKAN METODE CAMEL : STUDI KASUS PADA BANK SYARIAH DISELURUH DUNIA

The development of Islamic banking is currently experiencing a rapid progress. Because Islamic banks are considered not susceptible to the mortgage crisis that hit financial markets around the world in 2008, there is a rapid development of Islamic banking. Consequently, many conventional banks are open or convert Islamic business. The rapid development of the bank is also marked by the performance and health of the bank. This research aims to determine the differences of financial performance between pure Islamic banking and a hybrid Islamic banking ( I slamic branches of conventional bank) in 2011 around the world. Method of research from this thesis is using the method of hypothesis testing which conducted by non - parametric statistics testing, Two Independent Sample Test: Mann-Whitney U. The result showed that there is a significant difference regarding financial performance between pure Islamic banking and hybrid Islamic banking all around the world, especially from the ratio of KAP, BOPO and FDR. CAR, NPM and ROA ratio showed that there is no significant difference regarding financial performance of pure Islamic banking and hybrid Islamic banking.