Miracle-dz/UniFAR-FTUs huggingface dataset:
Real Time EEG Based Measurements of Cognitive Load Indicates Mental States During Learning

One of the recommended approaches in instructional design methods is to optimize the value of working memory capacity and avoid cognitive overload. Educational neuroscience offers novel processes and methodologies to analyze cognitive load based on physiological measures. Observing psychophysiological changes when they occur in response to the course of a learning session allows adjustments in the learning session based on the individual learner’s capabilities. The availability of non-invasive electroencephalogram (EEG)-based devices and advanced near-real-time analysis techniques have improved our understanding of the underlying mechanisms and have impacted the way we design instructional methods and adapt them to the current learner’s cognitive load and valence states. We will review Cognitive Load Theory, how cognitive load may be measured, and how analysis of EEG data can be applied to enhance learning through real-time measurements of the learner’s cognitive load. We show a learning experiment in an attempt to provide a proof of concept of learning and real-time measures of EEG as indicators of mental states.
Feature Location Using Crowd-Based Screencasts

Crowd-based multi-media documents such as screencasts have emerged as a source for documenting requirements of agile software projects. For example, screencasts can describe buggy scenarios of a software product, or present new features in an upcoming release. Unfortunately, the binary format of videos makes traceability between the video content and other related software artifacts (e.g., source code, bug reports) difficult. In this paper, we propose an LDA-based feature location approach that takes as input a set of screencasts (i.e., the GUI text and/or spoken words) to establish traceability link between the features described in the screencasts and source code fragments implementing them. We report on a case study conducted on 10 WordPress screencasts, to evaluate the applicability of our approach in linking these screencasts to their relevant source code artifacts. We find that the approach is able to successfully pinpoint relevant source code files at the top 10 hits using speech and GUI text. We also found that term frequency rebalancing can reduce noise and yield more precise results.
Variational Formulation for Wannier Functions with Entangled Band Structure

Wannier functions provide a localized representation of spectral subspaces of periodic Hamiltonians, and play an important role for interpreting and accelerating Hartree-Fock and Kohn-Sham density functional theory calculations in quantum physics and chemistry. For systems with isolated band structure, the existence of exponentially localized Wannier functions and numerical algorithms for finding them are well studied. In contrast, for systems with entangled band structure, Wannier functions must be generalized to span a subspace larger than the spectral subspace of interest to achieve favorable spatial locality. In this setting, little is known about the theoretical properties of these Wannier functions, and few algorithms can find them robustly. We develop a variational formulation to compute these generalized maximally localized Wannier functions. When paired with an initial guess based on the selected columns of the density matrix (SCDM) method, our method can robustly find Wannier functions for systems with entangled band structure. We formulate the problem as a constrained nonlinear optimization problem, and show how the widely used disentanglement procedure can be interpreted as a splitting method to approximately solve this problem. We demonstrate the performance of our method using real materials including silicon, copper, and aluminum. To examine more precisely the localization properties of Wannier functions, we study the free electron gas in one and two dimensions, where we show that the maximally-localized Wannier functions only decay algebraically. We also explain using a one dimensional example how to modify them to obtain super-algebraic decay.
Biogeosciences Quality control of CarboEurope flux data – Part 1 : Coupling footprint analyses with flux data quality assessment to evaluate sites in forest ecosystems

We applied a site evaluation approach combining Lagrangian Stochastic footprint modeling with a quality assessment approach for eddy-covariance data to 25 forested sites of the CarboEurope-IP network. The analysis addresses the spatial representativeness of the flux measurements, instrumental effects on data quality, spatial patterns in the data quality, and the performance of the coordinate rotation method. Our findings demonstrate that application of a footprint filter could strengthen the CarboEurope-IP flux database, since only one third of the sites is situated in truly homogeneous terrain. Almost half of the sites experience a significant reduction in eddy-covariance data quality under certain conditions, though these effects are mostly constricted to a small portion of the dataset. Reductions in data quality of the sensible heat flux are mostly induced by characteristics of the surrounding terrain, while the latent heat flux is subject to instrumentation-related problems. The Planar-Fit coordinate rotation proved to be a reliable tool for the majority of the sites using only a single set of rotation angles. Overall, we found a high average data quality for the CarboEurope-IP network, with good representativeness of the measurement data for the specified target land cover types.
Validation of the Swiss methane emission inventory by atmospheric observations and inverse modelling

Abstract. Atmospheric inverse modelling has the potential to provide observation-based estimates of greenhouse gas emissions at the country scale, thereby allowing for an independent validation of national emission inventories. Here, we present a regional-scale inverse modelling study to quantify the emissions of methane (CH4) from Switzerland, making use of the newly established CarboCount-CH measurement network and a high-resolution Lagrangian transport model. In our reference inversion, prior emissions were taken from the "bottom-up" Swiss Greenhouse Gas Inventory (SGHGI) as published by the Swiss Federal Office for the Environment in 2014 for the year 2012. Overall we estimate national CH4 emissions to be 196 ± 18 Gg yr−1 for the year 2013 (1σ uncertainty). This result is in close agreement with the recently revised SGHGI estimate of 206 ± 33 Gg yr−1 as reported in 2015 for the year 2012. Results from sensitivity inversions using alternative prior emissions, uncertainty covariance settings, large-scale background mole fractions, two different inverse algorithms (Bayesian and extended Kalman filter), and two different transport models confirm the robustness and independent character of our estimate. According to the latest SGHGI estimate the main CH4 source categories in Switzerland are agriculture (78 %), waste handling (15 %) and natural gas distribution and combustion (6 %). The spatial distribution and seasonal variability of our posterior emissions suggest an overestimation of agricultural CH4 emissions by 10 to 20 % in the most recent SGHGI, which is likely due to an overestimation of emissions from manure handling. Urban areas do not appear as emission hotspots in our posterior results, suggesting that leakages from natural gas distribution are only a minor source of CH4 in Switzerland. This is consistent with rather low emissions of 8.4 Gg yr−1 reported by the SGHGI but inconsistent with the much higher value of 32 Gg yr−1 implied by the EDGARv4.2 inventory for this sector. Increased CH4 emissions (up to 30 % compared to the prior) were deduced for the north-eastern parts of Switzerland. This feature was common to most sensitivity inversions, which is a strong indicator that it is a real feature and not an artefact of the transport model and the inversion system. However, it was not possible to assign an unambiguous source process to the region. The observations of the CarboCount-CH network provided invaluable and independent information for the validation of the national bottom-up inventory. Similar systems need to be sustained to provide independent monitoring of future climate agreements.
The decline of lions in Ghana’s Mole National Park

The decline of lions in Ghana’s Mole National Park A. Cole Burton*, Eric B. Buedi, Cletus Balangtaa, David G. Kpelle, Moses K. Sam and Justin S. Brashares Department of Environmental Science, Policy and Management, University of California, Berkeley CA, 947203114, U.S.A. , Department of Wildlife and Range Management, Kwame Nkrumah University of Science and Technology, Kumasi and Wildlife Division of the Forestry Commission of Ghana, PO Box M239, Accra, Ghana
Rapid Epidemiological Assessment of Lymphatic Filariasis in Northern Taraba Focus, Nigeria

This study was undertaken to determine the prevalence of Lymphatic Filariasis in eleven (11) foci communities of northern Taraba state. Blood samples were collected by finger prick method to determine the presence of filarial antigen in serum using immunochromatographic card test. Questionnaires and physical examinations were used to assess clinical manifestations associated with the infection. The result showed that 101/336 (30.02%) were positive for W. bancrofti circulating filarial antigen. The circulating filarial antigen prevalence among the eleven communities differ significantly (p 0.05). However, the antigenaemia prevalence among the age groups differs, with ages 51-60 years having the highest prevalence among male and ages 41-50 years among female respectively (χ2=11.424, df 6, P<0.05). Chronic clinical manifestation observed include Hydrocoel (17.12%) and lymphoedema of limbs (20.08%). Female had significant proportion of those with lymphoedema (14.8%). The findings showed a high prevalence of the infection which is far above the World Health Organisation threshold level of ≥1% prevalence as well as significant prevalence of clinical manifestations. Therefore integrated intervention programme is required in the study area.
The landscape of somatic mutation in sporadic Chinese colorectal cancer

Colorectal cancer is the fifth prevalent cancer in China. Nevertheless, a large-scale characterization of Chinese colorectal cancer mutation spectrum has not been carried out. In this study, we have performed whole exome-sequencing analysis of 98 patients’ tumor samples with matched pairs of normal colon tissues using Illumina and Complete Genomics high-throughput sequencing platforms. Canonical CRC somatic gene mutations with high prevalence (>10%) have been verified, including TP53, APC, KRAS, SMAD4, FBXW7 and PIK3CA. PEG3 is identified as a novel frequently mutated gene (10.6%). APC and Wnt signaling exhibit significantly lower mutation frequencies than those in TCGA data. Analysis with clinical characteristics indicates that APC gene and Wnt signaling display lower mutation rate in lymph node positive cancer than negative ones, which are not observed in TCGA data. APC gene and Wnt signaling are considered as the key molecule and pathway for colorectal cancer initiation, and these findings greatly undermine their importance in tumor progression for Chinese patients. Taken together, the application of next-generation sequencing has led to the determination of novel somatic mutations and alternative disease mechanisms in colorectal cancer progression, which may be useful for understanding disease mechanism and personalizing treatment for Chinese patients.
Does Size Matter? Factors Influencing the Spatial Ecology of Northern Pacific Rattlesnakes (Crotalus oreganus oreganus) in Central California

The spatial ecology of animals is influenced by a combination of factors. Spatial ecology parameters are commonly calculated for rattlesnakes of the genus Crotalus, but they are highly variable within and among populations and species. Rattlesnake movements can be influenced by sex, body size, season, and abiotic factors, but the relative importance of each still remains unknown. We quantified aspects of the spatial ecology of a population of Northern Pacific Rattlesnake (Crotalus oreganus oreganus) in the southern part of its range in order to determine the factors that influence its spatial ecology. We found that males had larger home range sizes than females for the entire 14-month study. However, sex differences in movements were present during the spring mating season but not the summer post-mating season, suggesting that male mate searching causes males to have larger overall home ranges than females. We also found that body size was not related to home range size, but this effect was sensitive to the inclusion of two outlier males. Our seasonal analyses revealed that outside the mating season, male body size was negatively related to mean daily movement, while female body size was positively related to mean daily movement. In the spring, larger males made their first long distance movement earlier than smaller males, suggesting that body size may influence the timing of mate searching activity. Our study shows that sex and season, which are influenced by the mating system, are important factors that determine the spatial ecology of C. o. oreganus.
The Influences of Early Temperament and Emotion Regulation on Social Competence in Middle Childhood

of a dissertation at the University of Miami. Dissertation supervised by Professor Heather Henderson. No. of pages in text. (75) Behaviorally inhibited children are predisposed toward social difficulties, but other environmental and within-child characteristics, such as emotion regulation, also influence social development. This study longitudinally examined: (1) independent influences of behavior inhibition and emotion regulation on future social competence, (2) associations between behavior inhibition and emotion regulation, and (3) the moderating role of emotion regulation on the relation between behavior inhibition and social competence. Participants (N = 257) were enrolled in a larger study of temperament and social development. Maternal-report questionnaires and behavioral observations (ages 2 and 3) were used to assess behavior inhibition. Children’s active and passive regulation strategy usage (age 5) was observed during a laboratory-based sadness-eliciting situation. Lastly, children participated in a free play task with an unfamiliar peer in the laboratory (age 7). Types of initiations, peers’ responses to initiations, and play sophistication during this task were coded to assess social competence. Latent variables for behavior inhibition, emotion regulation, and social competence were created. The structural model was analyzed using structural equation modeling. Results show that highly behaviorally inhibited children are predisposed to utilize less competent regulation strategies in a sadness-eliciting situation. Furthermore, competent sadness regulation was found to influence the relation between early behavior inhibition and future social competence with an unfamiliar peer. Overall study findings elucidate developmental trajectories of risk and resilience, which informs prevention practices, particularly for highly inhibited children who are at-risk for a range of social, emotional, and academic difficulties.
Zataria multiflora ameliorates cisplatin-induced testicular damage via suppression of oxidative stress and apoptosis in a mice model

Objective(s): Cisplatin (CP), as an anti-neoplastic drug, causes testicular damage. Zataria multiflora Boiss (ZM), a medicinal plant, has antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of ZM against CP-induced testicular toxicity. Materials and Methods: In this experimental study, thirty-two adult male mice were randomly divided into four groups. The control group received normal saline with oral gavage during 7 days; ZM group received ZM (200 mg/kg) during 7 days by gavage; CP group received CP (10 mg/kg) intraperitoneally (IP) in the 5th day of study; ZM + CP group received ZM during 7 days and CP was injected in 5th day. Sperm parameters, biochemical (MDA, GSH, and PC) levels, serum testosterone levels, and histopathological and immunohistochemical assays of testis were examined one day after the last drug treatment. Results: CP treatment caused significant damage via changed sperm parameters (sperm motility, count, viability rate, and abnormalities), increased oxidative stress (increased MDA and PC levels, and decreased GSH level), histological changes (degeneration, necrosis, arrest of spermatogenesis, congestion, and decrease in thickness of the germinal epithelium, diameter of seminiferous tubules, and Johnsen’s Score), decreased serum testosterone level, and increased caspase-3 immunoreactivity. ZM preserved spermatogenesis and mitigated the toxic effects of CP on the testis tissue. In addition, treatment with ZM significantly reduced caspase-3 immunoreactivity. Conclusion: The findings of this study suggest that ZM as a potential antioxidant compound and due to free radicals scavenging activities has a protective effect against CP-induced testicular toxicity.
Transient activation of Meox 1 is an early component of the gene 1 regulatory network downstream of Hoxa 2 . 2 3

1 regulatory network downstream of Hoxa2. 2 3 Pavel Kirilenko, Guiyuan He, Baljinder Mankoo, Moises Mallo, Richard Jones 5 4 and Nicoletta Bobola 5 6 (1) School of Dentistry, Faculty of Medical and Human Sciences, University of 7 Manchester, Manchester, UK. 8 (2) Randall Division of Cell and Molecular Biophysics, King's College London, UK. 9 (3) Instituto Gulbenkian de Ciência, Oeiras, Portugal. 10 (4) Genetic Medicine, Manchester Academic Health Science Centre, Central 11 Manchester University Hospitals NHS Foundation Trust, Manchester, UK. 12 (5) Present address: Department of Biology, University of York, York, UK. 13 14 Running title: Hoxa2 activates Meox1 expression. 15
Erich arch bar versus hanger plate technique for intermaxillary fixation in fracture mandible: A prospective comparative study

Introduction: Various methods have been described for intermaxillary fixation (IMF) for treatment of faciomaxillary injuries. Many studies have been described to evaluate the efficacy of different methods. Hanger plate method has not been commonly used. The aim of the present study was to compare the advantages and disadvantages of this method over Erich arch bar in mandibular fracture. Materials and Methods: Sixty patients of only mandibular fracture presenting to trauma center requiring open reduction and internal fixation under general anesthesia were randomly allocated to Group A and Group B comprising thirty patients in each. Group A included patients who received IMF with Erich arch bar. Group B included patients who received IMF with hanger plate method. The two groups were compared for time duration of intermaxillary procedure, total duration of surgery, oral hygiene score, postoperative occlusion, and complications. Results: The average time of intermaxillary procedure, total duration of surgery, and wire prick injuries were more in Group A. Oral hygiene score was significantly better in Group B. Postoperative occlusion was comparable between the two groups. There was screw loosening in four patients in Group B, but none had tooth root injury. The cost of material for IMF was more in Group B. Conclusion: IMF with hanger plate method is more safe and efficacious compared to Erich arch bar in the treatment of mandibular fractures.
Investigating Associations Between Changes in Mobile Phone Use and Emotions Using the Experience Sampling Method: Pilot Study

Background The use of mobile phones has become, especially for young people, an integrated part of everyday life. Using the experience sampling method (ESM) may provide further insight on the association between mobile phone use and mental health. Objective The objective of this study was to examine associations between mobile phone use and subtle changes in mental state. Methods The ESM-based PsyMate app was installed on the mobile phones of 2 healthy 20-year-old participants. Over a period of 3 months, participants rated their mental states at 10 semirandom moments in the flow of daily life. Each assessment included present state emotions, environmental circumstances, and phone use. Results Multilevel regression analyses indicated that an increase in mobile phone use was associated with a small increase in negative affect (particularly feeling bored and feeling lonely; P<.001) and small decreases in positive affect (P=.002) and concentration (P=.001). Treating the data as 2 separate N=1 studies revealed that the association with negative affect was present in both participants, whereas the associations with positive affect and concentration were evident in only 1 of the 2 participants. Conclusions This pilot study suggests that mobile phone use may be associated with person-specific and group-level changes in emotional state. A larger study is required to study these associations, possible causality, and factors driving underlying heterogeneity in the pattern of associations. Trial registration ClinicalTrials.gov NCT03221985; https://clinicaltrials.gov/ct2/show/NCT03221985 (archived by WebCite at http://www.webcitation.org/6zJnp61Wj)
Observed rapid bedrock uplift in Amundsen Sea Embayment promotes ice-sheet stability

A quick rebound for Antarctic crust Earth's crust deforms under the load of glaciers and ice sheets. When these masses are removed, the crust rebounds at a time scale determined by the viscosity of the upper mantle. Using GPS, Barletta et al. found that the viscosity of the mantle under the West Antarctic Ice Sheet is much lower than expected. This means that as ice is lost, the crust rebounds much faster than previously expected. Although estimates of total ice loss have to be revised upward, the surprising finding indicates that the ice sheet may stabilize against catastrophic collapse. Science, this issue p. 1335 A new viscosity model requires a much lower viscosity under the Amundsen Sea Embayment, stabilizing the Antarctic Ice Sheet. The marine portion of the West Antarctic Ice Sheet (WAIS) in the Amundsen Sea Embayment (ASE) accounts for one-fourth of the cryospheric contribution to global sea-level rise and is vulnerable to catastrophic collapse. The bedrock response to ice mass loss, glacial isostatic adjustment (GIA), was thought to occur on a time scale of 10,000 years. We used new GPS measurements, which show a rapid (41 millimeters per year) uplift of the ASE, to estimate the viscosity of the mantle underneath. We found a much lower viscosity (4 × 1018 pascal-second) than global average, and this shortens the GIA response time scale to decades up to a century. Our finding requires an upward revision of ice mass loss from gravity data of 10% and increases the potential stability of the WAIS against catastrophic collapse.