Miracle-dz/UniFAR-FTUs huggingface dataset:
Rhinosinusitis-Related Quality of Life during Pregnancy

Background Pregnancy rhinitis manifests as nasal congestion, with resolution of symptoms after delivery. Eighteen to 30% of pregnant patients report symptoms of rhinitis. Pregnancy rhinitis may have an adverse effect on quality of life (QOL) and may cause obstructive sleep apnea (OSA), which in turn may adversely affect the outcome of pregnancy. Previous examinations of the prevalence of pregnancy rhinitis during different stages of pregnancy have been inconclusive. This study aimed to determine rhinosinusitis-specific QOL during different stages of pregnancy. Methods A cross-sectional observation study of patients in the second and third trimesters of pregnancy using the 22-item Sino-Nasal Outcome Test (SNOT-22) was conducted in the obstetric clinic at McGill University Health Center in Montreal, Canada. Seventy-six low- risk pregnant patients were included in the study. Thirty-two patients were in the second trimester of pregnancy and 44 patients were in the third trimester. Results Average item scores for the entire questionnaire were significantly higher (p = 0.041), indicating more severe impairment of QOL, in the third trimester in comparison with the second trimester. A comparison between women with and without preexisting allergic rhinitis, in both the second and the third trimesters, shows significantly higher SNOT-22 scores for the allergic group (p = 0.007). QOL was lower in the third trimester than in nonrhinosinusitis patients (p = 0.011). Conclusion Rhinosinusitis-specific QOL is lower in the third trimester of pregnancy in comparison with the second trimester and also in comparison with nonrhinosinusitis patients. Increased awareness may enhance the QOL of pregnant patients, prevent OSA, and thereby positively influence the outcome of pregnancy.
Tooth size in dentitions with buccal canine ectopia

SUMMARY Much interest has been expressed in recent years regarding various features common to dentitions with palatally displaced canines (PDC), particularly in relation to delayed dental development and reduced tooth size. The aims of the present study were to determine whether dentitions with buccally displaced canines (BDC) have features in common, which may be specific for the condition, when compared with PDC dentitions and those with normally erupting canines. Mesiodistal and buccolingual tooth dimensions were determined for 41 subjects with BDC (21 females and 20 males) aged between 11 and 15 years, who formed the experimental sample. The PDC sample was made up of 58 individuals (37 females and 21 males) and the control group comprised 40 age-matched and consecutively treated subjects (20 males and 20 females), exhibiting normally erupted and undisplaced maxillary canines. The results revealed marked sexual dimorphism. Larger-than-average teeth were present in BDC females, whereas the teeth in BDC males were normally sized. Unilaterally affected females had smaller teeth than bilaterally affected females. Tooth size in BDC was consistently larger than in PDC subjects, although the reason was different between the sexes. In females the PDC teeth were normally sized versus large BDC teeth, whereas in the males, the PDC teeth were small and the BDC teeth normal. It is concluded that combining male and female subjects into an overall BDC group obscures important differences that exist between the two sexes.
Can Patients with Common Variable Immunodeficiency Have Allergic Rhinitis?

Background Rhinosinusitis is highly prevalent in patients with common variable immunodeficiency (CVID), and probably allergic rhinitis (AR) may be masked by a history of repeated respiratory infections. The diagnosis of AR is based on the patient's symptoms and detection of specific immunoglobulin E (IgE) to aeroallergens. This study was designed to identify rhinitis of probable allergic cause in patients with CVID. Methods This study included 72 adult CVID patients. The patients were divided into three groups according to their history: suggestive of AR, nonallergic rhinitis, and without rhinitis. They were tested for total and specific IgE (in vivo and in vitro). Results The patients’ mean age was 38.2 years. A history of chronic rhinitis was observed in 59 (81.9%) of the cases, 31 of which (43%) had a history suggestive of AR. Patients with a history of rhinitis (whether allergic or nonallergic) presented an earlier onset of symptoms and diagnosis of CVID. Total IgE was undetectable in 86.1% of patients. AR was confirmed by detection of specific IgE to aeroallergens in only 5.6% of the patients. Conclusion In CVID patients, chronic rhinitis may be allergic, because many have personal and family histories suggestive of atopy. However, in this study, allergy was confirmed by specific IgE detection in only 5.6% of cases. CVID patients with a history suggestive of AR commonly present negative results on traditional testing, so additional experiments may be necessary. One suggestion for the investigation of AR in CVID patients would be nasal provocation with the most prevalent allergens.
Sinonasal Complications Resulting from Dental Treatment: Outcome-Oriented Proposal of Classification and Surgical Protocol

Background Odontogenic sinusitis is a relevant infectious condition of the paranasal sinuses. The widespread use of dental implants and reconstructive procedures for dental implant placement has led to new types of complication. To the authors’ knowledge, no publication has extensively examined sinonasal complications resulting from dental treatment, and no classification system allowing standardization and comparison of results is currently available. This study was designed to (a) analyze the results obtained from surgical treatment of complications resulting from dental procedures combining functional endoscopic sinus surgery (FESS) and an intraoral approach and (b) propose a new classification system and standardized treatment protocols for sinonasal complications resulting from dental procedures. Methods A total of 257 patients consecutively treated with FESS (136 in conjunction with oral surgery) were included in the study. Different clinical situations were integrated into a new classification system based on the pathogenesis and clinical aspects of each case, with the aim of identifying homogenous treatment groups. Results were evaluated for each class. Results Of the 257 patients, 254 were successfully treated with surgery performed according to the proposed protocols. Three of 257 patients required a second surgery, after which they completely recovered. Complications of implant and preimplant surgery (maxillary sinus floor elevation) showed longer recovery times. Conclusion The results obtained are very encouraging. The majority of patients (254/257; 98.8%) were successfully treated with the proposed protocols. These results seem to indicate that the rationalization of surgical treatment protocols according to the initial clinical situation may significantly improve the clinical outcome.
Does Eosinophilic Inflammation Affect the Outcome of Endoscopic Sinus Surgery in Chronic Rhinosinusitis in Koreans?

Background The implication of eosinophilic inflammation in chronic rhinosinusitis (CRS) has not been sufficiently studied in Asians. The aim of this study was to evaluate the relationship between eosinophilic inflammation in sinonasal tissues and the surgical outcome of functional endoscopic sinus surgery (FESS) in Koreans. Methods A retrospective review of medical records was performed for 347 patients who had undergone bilateral FESS. During FESS, nasal polyp (NP) or sinonasal pathological mucosa was obtained and histopathological analyses were performed. For analyses of surgical outcomes, 173 patients whose follow-up was >12 months were included. The sinonasal cavity was evaluated by endoscopic examination at the last follow-up using a Lund-Kennedy endoscopic scoring system. Results Of 347 patients whose tissues were histologically evaluated, 250 (72%) had noneosinophilic CRS. The patients were categorized into four groups according to the presence of NP and eosinophilic inflammation. Of 173 patients, 43 patients (24.9%) had eosinophilic CRS with NP, 15 (8.7%) had eosinophilic CRS without NP, 74 (42.7%) had noneosinophilic CRS with NP, and 41 (23.7%) had noneosinophilic CRS without NP. There were no statistically significant differences in prevalence of allergic rhinitis and asthma and in their preoperative Lund-Mackay scores among four groups. Also, there was no statistically significant difference in the postoperative Lund-Kennedy score between eosinophilic and noneosinophilic CRS groups. Conclusion The results suggest that eosinophilic inflammation in CRS may not be related to the surgical outcome in Koreans.
Metformin treatment for gestational diabetes

The prevalence of gestational diabetes mellitus (GDM) is rising as the pregnant population becomes older and more obese. This is concerning because GDM is associated with increased perinatal morbidity such as macrosomia and shoulder dystocia, and the need for instrumental delivery. In addition, the offspring of GDM women have increased long-term risks of obesity and type 2 diabetes. There is no doubt that treating women with GDM improves pregnancy outcomes. Conventionally this has been by diet and insulin. Although effective, insulin increases appetite leading to weight gain. It increases the risk of hypoglycaemia and needs to be given by injection. There is also a substantial cost in terms of time for teaching and educating patients. Metformin offers a logical alternative to insulin in GDM, by reducing insulin resistance. Recent trial evidence indicates it is safe and effective. We describe our experience with metformin in GDM and review the evidence. Br J Diabetes Vasc Dis 2009;9:220-225
A Pilot Open-Label Trial of Use of the Glycine Transporter I Inhibitor, Sarcosine, in High-Functioning Children with Autistic Disorder

This open-label trial examined the efficacy and safety of a glycine transporter I inhibitor, sarcosine, in the 24-week treatment of high-functioning children with autistic disorder. Four children (three boys, one girl, 9-11 years of age; average intelligence quotient 80.5) completed the 24 weeks of study. Sarcosine administration was at 30 mg/kg/day in the form of a capsule in two divided doses. The outcome measures were. Autism Diagnostic Observation Schedule (Module 3), parent and teacher-reported Adaptive Behavior Assessment System-II, parenting stress index, Conners’ Continuous Performance Test, Wisconsin Card Sorting Test, child behavior checklist and Swanson, Nolan and Pelham IV hyperactivity attention scales. Safety assessments included monthly recorded vital signs, body weight, body height and adverse events. Statistical analysis found no significant treatment effect on all the outcome measures using the Wilcoxon Signed Rank test and generalized estimating equations analysis. However, an activation effect was reported by caregivers, and was corroborated by clinician’s observation. Details were reported as a case-series in the text. We concluded that sarcosine was well tolerated. Though the data are too preliminary to draw any definite conclusions about efficacy, they do suggest this therapy to be safe, and worthy of a double-blind placebo-controlled study with a focus on a certain subgroup of children with autism spectrum disorders.
Trauma injuries sustained by female footballers

Soccer is becoming the leading sport for women worldwide with 21 million females registered with the Federation Internationale de Football Association (FIFA). It is now the top female sport in England with 131 678 registered players and 9600 registered clubs. Several studies have looked at the injury rates amongst female players. Some injuries have been highlighted as more common in women. This article looks at the epidemiology of injuries in women's soccer and in particular anterior cruciate ligament injuries, ankle injuries and concussion. It will discuss the diagnosis and management needed for these injuries in female soccer players. With this increasing popularity, clinicians will see more female players sustaining trauma through playing soccer. Early and appropriate management of these injuries is essential if women are to continue to enjoy soccer at a recreational level and succeed at a competitive level, perhaps with a podium finish in 2012.
Endoscopic Dacryocystorhinostomy with Silicone, Polypropylene, and T-tube Stents; Randomized Controlled Trial of Efficacy and Safety

Objective To compare the efficacy and safety of endoscopic dacryocystorhinostomy (En-DCR) with different stent materials for lacrimal sac intubation in primary nasolacrimal ductal obstructions. Study Design Randomized controlled study with three parallel groups. Level of evidence is 1b. Methods A total of 91 patients (five bilateral) with primary nasolacrimal duct obstruction (NLDO) at a tertiary referral center scheduled for En-DCR were to allocated into three stent groups with a sealed envelope and were randomized into three treatments: silicone, Prolene (polypropylene), and otologic T-tube. Ophthalmology and otolaryngology clinics evaluated the patients preoperatively and postoperatively with endoscopes, lacrimal system syringing, and dacryocystography. The success of the stents was evaluated 12 months after surgery with symptom relief and ostial patency. Complications were also noted. Results The overall success rate of the En-DCR in the stent groups was 78.1% (75/96); specifically, 87.5% (28/32) with silicone, 84.4% (27/32) with Prolene, and 62.5% (20/32) with T-tube. The efficacy of the procedures with the T-tube was significantly lower than that of the Prolene and silicone (p = .031, χ2 test). There were no significant differences between the silicone and Prolene (p = .718, χ2 test). Prolene was found to be related with orbital complications. Spontaneous loss is a particular complication of otologic T-tube and highly portends to failure. Conclusions The results of our study suggest that efficacy, defined as anatomic and functional success, is equally high for silicone and Prolene stents and lower for otologic T-tube in En-DCR.
DURAL HEADACHE AND INNERVATION OF THE DURA MATER

The only adjective which Celsus applied to headache was "intolerabilis. " Unless it was intolerable, he said, there was no necessity for a remedy (Vaughan, 1825 1 ). Today the same proviso might be applied, at least to surgical remedies. But when the ache is intolerable, radical operative treatment should be undertaken. Knowledge of the innervation and sensitivity of intracranial structures is prerequisite to success with such treatment. This study is concerned primarily with the nerve supply and pain reference of the dura mater in man and in the monkey. It is illustrated by clinical cases which cast light on dural sensitivity and on the radical treatment of falcial cicatrix, migraine and other forms of headache. A preliminary anatomic study has already been published by one of us (F. M.). 2 STRUCTURE AND DEVELOPMENT OF THE CEREBRAL DURA MATER The cerebral dura is a very tough membrane composed of two closely adherent
Occupational noise induced hearing loss and hearing threshold profile at high frequencies

Background: The textile workers exposed to industrial noise are prone to develop hearing loss concentrated mainly at high audible frequencies. It is affected by duration of exposure and type of noise. Aims: Present study was conducted to (a) investigate hearing thresholds of textile workers by pure tone audiometry, (b) correlate thresholds at 4 kHz, 6 kHz and 8 kHz between noise exposed and unexposed group and (c) study effect of duration of exposure on hearing profile. Materials and Methods: A cross-sectional study was carried out on 50 weavers of plastic industries exposed to high levels of constant noise. Objectively, hearing defects were inquired by self-administered questionnaires. Subjectively, pure tone audiometry was carried out to measure hearing thresholds at various frequencies. It was simultaneously compared with the similar data of matched control group. Results: Prevalence of hearing loss symptom and hearing thresholds were more in exposed group than in control group. There was significant hearing loss at high frequency as compared to lower ones. Audiometry revealed notch at 4 kHz with less effect at 6 or 8 kHz, cumulative effect of duration of exposure. Conclusion: Textile weavers are more at risk to develop Occupational Noise Induced Hearing Loss (ONIHL) mainly affecting higher frequencies concentrated at 4 kHz. Despite least effects on hearing, this disease silently progresses and there is a definite scope of prevention by appropriate protective measures.
Living with chronic risk: healthy women with a family history of breast/ovarian cancer

This paper investigates how healthy women with a family history of breast/ovarian cancer live with their heightened awareness of risk, and introduces a chronic risk perspective for studying this topic. Healthy women from these at-risk families and individuals suffering from a chronic illness address many of the same issues concerning adaptation to biographical disruption and an uncertain future. We report on risk perception, family history, life stages, biographical interruptions and the women's attempts to control their risk through a healthy life style and health care beliefs and practices. We conducted an exploratory, qualitative study at a major clinical and research cancer centre in the UK from January – June 2000 that was approved by the hospital clinical research and ethics committees. Twenty-one semi-structured, in-depth interviews were conducted using a purposive sample of women coming to the cancer genetics risk clinic for the first time. We found that the women used various coping strategies in order to ‘get on with their lives’—one not dominated by thoughts about long-term risk for cancer. Many women believed that a healthy life style, stress reduction and participating in an annual screening programme for breast/ovarian cancer was the best way to achieve their goal.
MRI is the most effective initial diagnostic study for osteomyelitis of the foot in diabetic patients

What is the best initial diagnostic study that should be used for a suspected osteomyelitis diagnosis? A critical review and clinical application of: Kapoor A, Page S, LaValley M, Gale DR, Felson DT. Magnetic resonance imaging for diagnosing foot osteomyelitis: a meta-analysis. Arch Intern Med. 2007;167(2):125-132. doi:10.1001/archinte.167. 2.125.
Student Perceptions of Digital Textbooks in a College Nursing Program

Follow this and additional works at: http://digitalcommons.unl. edu/journalismdiss Part of the Communication Technology and New Media Commons, Curriculum and Instruction Commons, Higher Education and Teaching Commons, Instructional Media Design Commons, Journalism Studies Commons, Mass Communication Commons, Other Communication Commons, Other Education Commons, Other Medicine and Health Sciences Commons, Other Nursing Commons, and the Secondary Education and Teaching Commons
Recombinant factor VIII Fc (Biogen/Swedish Orphan Biovitrium) for the treatment of hemophilia A

Introduction: Current prophylactic management of hemophilia A (HemA) involves administration of intravenous factor VIII (FVIII) 3 – 4 times weekly. Fc fusion protein technology uses the natural neonatal Fc receptor (FcRn) receptor to extend the half-life of Fc-associated therapeutic proteins. A recombinant factor VIII Fc fusion protein (rFVIIIFc) with a half-life 1.5 – 1.7-fold longer than unmodified rFVIII has now been developed. Areas covered: This review outlines the FcRn recycling pathway and the development of Fc fusion drugs. rFVIIIFc was successfully tested in HemA mice and dogs and demonstrated a good safety profile in a Phase I/IIa study in previously treated subjects with severe hemophilia A. In a pivotal Phase III study of subjects with severe hemophilia A, rFVIIIFc had a prolonged half-life compared with rFVIII and was well tolerated and efficacious in the prevention and treatment of bleeding events. Expert opinion: A shift from alternate day dosing to once or twice weekly dosing for HemA patients enhances convenience of treatment without compromising safety. The increased dose interval is not a radical change in hemophilia management, but is the first significant manufacturer response to the need of hemophilia patients and their physicians for therapies that have simpler and more convenient dosing regimens.
Relationships Among Walking Aids, Physical Activity, Depression, Fatigue, and Perceived Health in Assisted-Living Residents

This study assesses whether physical activity, depression, fatigue, or perceived health are affected by use of a walking aid in residents of an assisted-living facility. From an assisted-living facility, 21 participants who were independent ambulators (n = 8) or who used a cane or walker (n = 13) participated. Physical activity was measured with accelerometers, and depression, fatigue, and perceived heath status were assessed with questionnaires. There were no differences in physical activity, depression, fatigue, or perceived health status between those using and those not using assistive devices. However, 15% of the participants reported moderate to severe depression, and 40% of participants reported at least mild depression. Depression was strongly correlated to fatigue. Thus, physical activity, depression, fatigue, and perceived health are not associated with walker or cane use in assisted-living facilities. Nevertheless, among all, mild depression is prevalent and strongly correlated to fatigue.
To Assess the Knowledge of Blood Donation among Voluntary Blood Donor at Blood Bank, Krishna Hospital Karad (Maharashtra, India)

The theme of the 2012 World Blood Donor Day campaign, “Every blood donor is a hero” focuses on the idea that every one of us can become a hero by giving blood. Today, Blood Transfusion Services constitute a crucial part of any healthcare delivery system. Adequate and safe supply of blood and blood components is essential, to enable a wide range of critical care procedures to be carried out in hospitals. The objective of the present study was to identify the level of knowledge of blood donation among voluntary blood donors attending blood bank of Krishna Hospital Karad and to correlate the knowledge with sociodemographic variables. 100 voluntary Blood donors between the ages of 18 and 55 years were selected by Non probability Convenient Sampling technique. Descriptive Survey Design was employed for study. Structured knowledge questionnaire was given to assess their knowledge on Blood Donation. The study sample consisted of 64 males (64%) and 36 females (36%). The overall knowledge on blood donation among respondents was observed as good 10%, average 56%, and poor 34%. In males the overall knowledge level was found good among 9%, average 52% and poor 39%. In females, good knowledge level was observed among 14%, average 49%, and poor 37%. Education and gender was significantly associated with knowledge of blood donation where as education religion blood group and age were not statistically significant. In the present study researcher concluded that there is need for health education regarding blood donation, which will ultimately increases the awareness among general population to motivate for voluntary blood donation.