Miracle-dz/UniFAR-FTUs huggingface dataset:
Rural-Urban Migration and Its Consequences on Rural Children: An Empirical Study

Rural-urban adult migration, mainly adult male migration makes heavy demand on all family members, but especially on children who are left behind in rural area to shoulder the responsibility of agriculture production and food security. Labor shortage due to rural-urban adult migration may mean that children in rural area often have to face tighter time schedules and patterns of time use and human energy inputs required in agriculture production. The study revealed the impact of rural-urban migration on rural children. In the study, sample was restricted to households that own and/or operate agricultural land in rural area. A purposive sampling was adopted to select villages and covered 500 sample households. The study was based on link between rural-urban migration of adult persons and child labor in rural area. The empirical result showed that an additional rural migrant of a household increases the probability of having child worker in that household by approximately 51%. However, it was found that children of migrant households receive less preventive health care in their infancy. The study also showed that an additional adult worker of a household increases the probability of having child worker in that household by 29%. For this reason, this study supports the hypothesis that children are the last economic resource of a household.
High-Resolution THz transmission and birefringence measurements in ferroelectric LiNbO3

We investigate single-crystal, ferroelectric LiNbO3 as a polarization transformer in the region 400 GHz to 1.0 THz, and extract the THz birefringence and attenuation coefficient from high-resolution photomixer spectrometer data. We also report narrow absorption resonances whose frequency is practically independent of sample thickness and whose strength decreases between 400 GHz and 1.0 THz. These are preliminarily associated with bulk-polaron oscillations.
p200, a collagen secreted by Schwann cells, is expressed in developing nerves and in adult nerves following axotomy

Previously we reported that cultured rat Schwann cells secrete p200, a collagen‐like heparin‐binding adhesive glycoprotein with a restricted pattern of expression. Here we report that p200 is secreted as a stable trimer, but only after treatment of Schwann cells with ascorbic acid, and was deposited in the fibrillar extracellular matrix. Heparin and heparitinase treatment inhibited incorporation of p200 into extracellular matrix, suggesting the involvement of Schwann cell heparan sulfate proteoglycans in this process. Pepsin digestion revealed that p200 secreted by ascorbate‐treated cells contains a collagenous domain of approximately 140 kDa. Immunofluorescent staining of rat embryos at different ages showed that p200 first appeared between embryonic days 15 and 18, and was confined to peripheral nerves. Staining of adult peripheral nerve was negative, but p200 expression was induced in adult sciatic nerve following nerve transection. These data suggest that p200 carries out unique functions during peripheral nerve development and regeneration and that its expression by Schwann cells is regulated by axon‐Schwann cell interaction. J. Neurosci. Res. 56:284–294, 1999. © 1999 Wiley‐Liss, Inc.
Quality Protein Maize Based on Reducing Sulfur in Leaf Cells

Low levels of the essential amino acids lysine (Lys) and methionine (Met) in a maize-based diet are a major cost to feed and food. Lys deficiency is due to the abundance of Lys-poor proteins in maize kernels. Although a maize mutant, opaque-2 (o2), has sufficient levels of Lys, its soft kernel renders it unfit for storage and transportation. Breeders overcame this problem by selecting quantitative trait loci (QTL) restoring kernel hardness in the presence of o2, a variety called Quality Protein Maize (QPM). Although at least one QTL acts by enhancing the expression of the γ-zein proteins, we could surprisingly achieve rebalancing of the Lys content and a vitreous kernel phenotype by targeting suppression of γ-zeins without the o2 mutant. Reduced levels of γ-zeins were achieved with RNA interference (RNAi). Another transgenic event, PE5 expresses the Escherichia coli enzyme 3′-phosphoadenosine-5′-phosphosulfate reductase involved in sulfate assimilation, specifically in leaves. The stacked transgenic events produce a vitreous endosperm, which has higher Lys level than the classical opaque W64Ao2 variant. Moreover, due to the increased sulfate reduction in the leaf, Met level is elevated in the seed. Such a combination of transgenes produces hybrid seeds superior to classical QPMs that would neither require a costly feed mix nor synthetic Met supplementation, potentially creating a novel and cost-effective means for improving maize nutritional quality.
The high frequency component of heart rate variability reflects cardiac parasympathetic modulation rather than parasympathetic 'tone'.

This study was designed to evaluate the effect of modulating cardiac parasympathetic input on the high frequency component of heart rate variability. We stimulated the right vagus nerve with three different stimulation patterns in anaesthetized, vagotomized and spinal anaesthetized dogs. We kept the mean stimulation frequency constant; controlled the amplitude of modulation with programmed stimulation patterns, and analysed the resulting heart rate variability by power spectral analysis. Constant frequency vagal stimulation increased the cardiac interval, but did not change heart rate variability markedly. There was a slight increase, from 11 +/- 2 to 27 +/- 11 ms2, in the high frequency component. However, when the instantaneous stimulation frequency oscillated between 4 and 17 Hz during 5 s period, we could produce a marked heart rate variation, with 91 +/- 9% of the variation corresponding to the frequency of the modulation (0.20 Hz). The high frequency component was 12932 +/- 7701 ms2. With an increased magnitude of modulation, i.e. the difference between minimum and maximum instantaneous frequency, the high frequency component increased to 32711 +/- 17943 ms2. Thus, the high frequency component of heart rate variability reflects the magnitude of fluctuation in the cardiac parasympathetic input rather than parasympathetic 'tone'.
Public management reform in Malaysia: Recent initiatives and experiences

Purpose – The present paper seeks to examine the recent changes in public management in Malaysia in relation to new public management and assess their impacts on administrative performance and service delivery.Design/methodology/approach – The scope of the paper is limited to the period of 1981 till the present date. The paper is mainly based on secondary sources of information, and it uses a combination of descriptive and analytical methods.Findings – The paper shows that although reforms are steps in the right direction, their impacts so far have been modest. Despite reforms and a few improvements they have made in service provisions, the public bureaucracy in Malaysia continues to suffer from inefficiency, corruption and a host of other problems.Originality/value – The paper shows the gap between rhetoric and reality of public management reforms in Malaysia. It is expected to be of great value to all those interested in public management – be they in academia or in policy circles.
Twentieth century surge of excess adult male mortality

Significance Female life expectancy now exceeds that of males in all countries. Although this gender difference has become accepted as normal, it is a relatively recent demographic phenomenon that emerged with the reduction of infections and the increase in the share of adult mortality attributed to cancer and cardiovascular disease. Heart disease is the main condition associated with increased excess male mortality, making the strongest contributions in birth cohorts of 1900–1935. Smoking behavior accounts for about 30% of male excess mortality at ages 50–70 for those born in 1900–1935. The remaining excess male mortality may be explained by underlying traits of vulnerability to cardiovascular disease that emerged with the reduction of infections and changes in diet and other lifestyle factors. Using historical data from 1,763 birth cohorts from 1800 to 1935 in 13 developed countries, we show that what is now seen as normal—a large excess of female life expectancy in adulthood—is a demographic phenomenon that emerged among people born in the late 1800s. We show that excess adult male mortality is clearly rooted in specific age groups, 50–70, and that the sex asymmetry emerged in cohorts born after 1880 when male:female mortality ratios increased by as much as 50% from a baseline of about 1.1. Heart disease is the main condition associated with increased excess male mortality for those born after 1900. We further show that smoking-attributable deaths account for about 30% of excess male mortality at ages 50–70 for cohorts born in 1900–1935. However, after accounting for smoking, substantial excess male mortality at ages 50–70 remained, particularly from cardiovascular disease. The greater male vulnerability to cardiovascular conditions emerged with the reduction in infectious mortality and changes in health-related behaviors.
Reciprocal Interaction between Two Cellular Proteins, Purα and YB-1, Modulates Transcriptional Activity of JCVCY in Glial Cells

ABSTRACT Cross communication between regulatory proteins is an important event in the control of eukaryotic gene transcription. Here we have examined the structural and functional interaction between two cellular regulatory proteins, YB-1 and Purα, on the 23-bp sequence element derived from the enhancer-promoter of the human polyomavirus JCV. YB-1 and Purα are single-stranded DNA binding proteins which recognize C/T- and GC/GA-rich sequences, respectively. Results from band shift studies demonstrated that while both proteins interact directly with their DNA target sequences within the 23-bp motif, each protein can regulate the association of the other one with the DNA. Affinity chromatography and coimmunoprecipitation provide evidence for a direct interaction between Purα and YB-1 in the absence of the DNA sequence. Ectopic expression of YB-1 and Purα in glial cells synergistically stimulated viral promoter activity via the 23-bp sequence element. Results from mutational studies revealed that residues between amino acids 75 and 203 of YB-1 and between amino acids 85 and 215 of Purα are important for the interaction between these two proteins. Functional studies with glial cells indicated that the region within Purα which mediates its association with YB-1 and binding to the 23-bp sequence is important for the observed activation of the JCV promoter by the Purα and YB-1 proteins. The results of this study suggest that the cooperative interaction between YB-1 and Purα mediates the synergistic activation of the human polyomavirus JCV genome by these cellular proteins. The importance of these findings for cellular and viral genes which are regulated by Purα and YB-1 is discussed.
Influenza Vaccination and Cardiovascular Mortality in Women and Men at Least 60 Years of Age in the Metropolitan Area of São Paulo, Brazil

Objectives: Influenza (flu) vaccination has been associated with a reduction in cardiovascular mortality in a metropolitan area of Brazil. Nevertheless, it is unknown whether sex influences this outcome. The aim of the study was analyze the cardiovascular disease (CVD) mortality in women and men before and after the initiation of a flu vaccination program. Methods: We analyzed the mortality of ischemic heart disease (IHD), stroke, and external causes (EC) in women and men at least 60 years of age in the metropolitan area of São Paulo before and after the initiation of a flu vaccination program. Estimates of the population were obtained from the Brazilian Institute of Geography and Statistics and the mortality data from the Ministry of Health for the period between 1980 and 2006. The risk of death was adjusted by the direct method using the 1960 world standard population. Results: Change in trend in mortality after vaccination was significant only for IHD (-9.3% vs -30.2%; P = .022) and remained unchanged for stroke (-31.4% vs -25.3%; P =.931) and EC (-8.5% vs -1.2%; P = .941). The decline in IHD pre- (1980-1995) and post-vaccination (1996-2006) was greater in women (-3.8% vs -28.8%; P = .001) than in men (-12.9% vs -30.4%; P = .054). Conclusion: Flu vaccination was associated with a significant reduction of IHD mortality, more so in women than in men.
Molecular Defects That Cause Loss of Polysialic Acid in the Complementation Group 2A10*

Polysialic acid (PSA) is a dynamically regulated posttranslational modification of the neural cell adhesion molecule (NCAM), which modulates NCAM binding functions. PSA biosynthesis is catalyzed by two polysialyltransferases, ST8SiaII and ST8SiaIV. The catalytic mechanisms of these enzymes are unknown. In Chinese hamster ovary cells, ST8SiaIV is responsible for PSA expression. In the complementation group 2A10, the ST8SiaIV gene is disrupted. Investigating the molecular defects in this complementation group, seven clones with missense mutations in ST8SiaIV were found. Mutations cause replacement of amino acids that are highly conserved in α2,8-sialyltransferases. To verify the physiological relevance of identified mutations, identical amino acid substitutions were introduced into epitope-tagged variants of hamster ST8SiaIV and murine ST8SiaII and recombinant proteins were tested in vivo andin vitro. None of these constructs reconstituted PSA synthesis in 2A10 cells, although the proteins were expressed and with the exception of the cysteine variants ST8SiaIV-C356F and ST8SiaII-C371F correctly targeted to the Golgi apparatus. Interestingly, two mutations (ST8SiaIV-R277G and -M333V and the corresponding mutants ST8SiaII-R292G and -M348V) could be partially rescued if tested in vitro. Although these mutants were negative for autopolysialylation, partial reconstitution of both auto- and NCAM polysialylation was achieved in the presence of NCAM. The data presented in this study suggest a functional link between auto- and NCAM polysialylation.
Perception of risk and shared decision making process in multiple sclerosis

ABSTRACT Introduction: Multiple sclerosis (MS) treatment has changed considerably in recent years thanks to the introduction of ever-more-powerful drugs. Unfortunately, the higher efficacies of these therapies are associated with increased risks of severe adverse events. In this scenario, neurologists and persons with MS (pwMSs) must now balance benefits and risks when making decisions regarding MS management. Areas covered: This review highlights the importance of the risk perception of pwMSs and their neurologists in the shared decision-making process in MS management, taking into account different ways improve the empowerment and engagement of pwMSs. Expert commentary: The shared decision-making process in MS is strongly influenced by an individual’s risk perception, which is dynamic and influenced by the personal, emotional, social, and experiential factors of both the pwMSs and neurologists.
Transnational Learning and Civil Society Empowerment in the EU Enlargement Process

Strengthening civil society as a domestic safeguard against the backsliding of reforms is a cornerstone of the EU enlargement process. Support provided by the EU, however, was shown to have had limited effects in triggering civil society empowerment in candidate countries. Adopting a novel perspective, this article demonstrates that the diffusion of mobilization formats, via transnational learning between activists from different enlargement rounds, facilitated the empowerment of non‐governmental organizations (NGOs) in countries joining later. Drawing on comparative evidence from Serbia and Montenegro, it shows how such transfers of external models enabled NGOs to feed into the ongoing membership talks. Their influence over substantive outcomes, however, was limited by a lack of domestic responsiveness, while funding availability constrained the operation of the transferred formats. These findings shed light on an overlooked dimension of learning in the context of Europeanization and feed into the debate on civil society empowerment in enlargement countries.
Global Financial Cycles and Risk Premiums

AbstractThis paper studies the synchronization of financial cycles across 17 advanced economies over the past 150 years. The comovement in credit, house prices, and equity prices has reached historical highs in the past three decades. While comovement of credit and house prices increased in line with growing real sector integration, comovement of equity prices has increased above and beyond growing real sector integration. The sharp increase in the comovement of global equity markets is particularly notable. We demonstrate that fluctuations in risk premiums, and not risk-free rates and dividends, account for a large part of the observed equity price synchronization after 1990. We also show that US monetary policy has come to play an important role as a source of fluctuations in risk appetite across global equity markets. These fluctuations are transmitted across both fixed and floating exchange rate regimes, but the effects are more muted in floating rate regimes.
Autophagy is involved in high glucose-induced heart tube malformation

Both pre-gestational and gestational diabetes have an adverse impact on heart development, but little is known about the influence on the early stage of heart tube formation. Using early gastrulating chick embryos, we investigated the influence of high glucose on the process of heart tube formation, specifically during the primary heart field phase. We demonstrated that high-glucose exposure resulted in 3 types of heart tube malformation: 1) ventricular hypertrophy, 2) ventricular hypertrophy with dextrocardia and 3) ventricular hypertrophy and dextrocardia with the fusion anomaly of a bilateral primary heart tube. Next, we found that these malformation phenotypes of heart tubes might mainly originate from the migratory anomaly of gastrulating precardiac mesoderm cells rather than cell proliferation in the developmental process of bilateral primary heart field primordia. The treatment of rapamycin (RAPA), an autophagy inducer, led to a similar heart tube malformation phenotype as high glucose. Additionally, high-glucose exposure promoted the expression of the key autophagy protein LC3B in early chick tissue. Atg7 is strongly expressed in the fusion site of bilateral primary heart tubes. All of these data imply that autophagy could be involved in the process of high-glucose-induced malformation of the heart tube.
The Effects of Financial Incentives on Women’s Performance: The Tournament Theory Applied to Female Tennis Players

The purpose of this paper is to analyze the management model of women’s professional tennis by using the theoretical framework of the tournament theory. Indeed, this sport is particularly appropriate to study the effects of financial incentives on women’s performance in the context of competitive elimination tournament. Moreover, we take into account the direct opposition between players by building two relative performance indicators. Empirical tests are conducted, by using Ordinary Least Squares method, on the whole tournaments played by the 30 best women’s tennis players, over the 2011 season. Interesting implication found is that one tournament theory principle, the incentive effect, is confirmed. In other words, an undistributed prize structure between tournament rounds increases the player performance. However, the other consequence of the tournament theory, the participative effect, is rejected because the monetary gains distributed by the tournament’s organizer (either the premium earned or the total dollar endowment) do not induce better player performance.
Construct Validity of an Objective Structured Clinical Examination (OSCE) in Psychiatry: Associations With the Clinical Skills Examination and Other Indicators

Objective: The construct validity of checklist and global process scores for an objective structured clinical examination (OSCE) in psychiatry was assessed. Multiple regression analysis was used to predict psychiatry OSCE scores from the clinical skills examination, an obstetrics/gynecology (OB/GYN) OSCE, and the National Board of Medical Examiners (NBME) psychiatry subject examination. Methods: Archival data from two successive classes of third-year medical students (1999–2000, N=142; 2000–2001, N= 144) were aggregated and analyzed. Results: The pattern and magnitude of convergence and discrimination were indicative of adequate construct validity for both the psychiatry checklist scores and the global process score. Clinical skills examination scores for history taking, interpersonal skills, and physical examination were related to psychiatry OSCE scores that reflected the same skill set. Construct validity was fairly higher for the global process rating. Conclusion: Evidence of construct validity of a psychiatry OSCE was obtained from multiple measures of performance, including the clinical skills examination. Findings lend support to the continued use of checklist and global process evaluations as part of OSCEs in psychiatry.
New CFOA-Based Single-Element-Controlled Sinusoidal Oscillators

New single-element-controlled sinusoidal oscillator (SECO) circuits using only two current-feedback operational amplifiers (CFOAs) and only five passive elements [two/three grounded capacitors (GC) and three/two resistors] are presented, which not only enlarge the previously known class of two-CFOA-GC SECOs but also provide new configurations that possess properties not available in the previously known circuits. The new oscillators are useful from the viewpoint of applications in several instrumentation and measurement situations such as oscillator-based capacitance measurement schemes, realization of very low frequency oscillators, and the design of voltage-controlled oscillators. Experimental results based upon commercially available AD844-type CFOAs are included, which confirm the practical workability of the new oscillator configurations
Brain somatic representation of phantom and intact limb: a fMRI study case report

Reports on phantom limb patients concerning neuronal reorganization using non‐invasive methods have focused mainly on the cortical regions and suggest the presence of pain as the cause of this reorganization. The phantom limb, however, includes other somatic and motor sensations other than pain. Here we describe the results of non‐painful stimulation in cortical and subcortical lateralization and reorganization and also examine the involvement of subcortical structures in phantom limb telescoping perception. We describe an enlarged contralateral cortical representation of the stump, a cortical and thalamic bilateral representation of the remaining leg, and a neuronal correlate of a telescoping perception of the phantom limb. The missing leg produces an enlarged cortical representation due to abnormal information and the remaining leg has a bilateral SII representation, which could be related to new, compensatory functions. The telescoping perception of a phantom limb by the stimulation of misallocation points was correlated with lenticular nuclei, thalamic and cingulate gyrus activation.