Miracle-dz/UniFAR-FTUs huggingface dataset:
D2-Net: A Trainable CNN for Joint Description and Detection of Local Features

In this work we address the problem of finding reliable pixel-level correspondences under difficult imaging conditions. We propose an approach where a single convolutional neural network plays a dual role: It is simultaneously a dense feature descriptor and a feature detector. By postponing the detection to a later stage, the obtained keypoints are more stable than their traditional counterparts based on early detection of low-level structures. We show that this model can be trained using pixel correspondences extracted from readily available large-scale SfM reconstructions, without any further annotations. The proposed method obtains state-of-the-art performance on both the difficult Aachen Day-Night localization dataset and the InLoc indoor localization benchmark, as well as competitive performance on other benchmarks for image matching and 3D reconstruction.
The Interdecadal Fluctuation of Dry and Wet Climate Boundaries in China in Recent 50 Years

Based on the annual mean precipitation and evaporation data of 295 stations covering 1951-1999, the aridity index is calculated in this paper. The climatic regions in China are classified into three types, namely, arid region, semi-arid region and humid region. The number 0.20 (D) is the boundary between arid and semi-arid regions and 0.50 (D) is the boundary between semi-arid and humid climate regions. Dry and wet climate in China fluctuates markedly and differentiates greatly in each region in recent 50 years. The fluctuation amplitude is 20-400 km in Northeast China, 40-400 km in North China, 30-350 km in the eastern part of Northwest China and 40-370 km in Southwest China in recent 40 years. Before the 1980s (including 1980), climatic trend was dry in Northeast and North China, wet in the eastern part of the Northwest and very wet in the Southwest. In the 1990s dry signs appeared in the Southwest, the eastern part of Northwest China and North China. During the 1960s and 1970s dry and wet climates in China had single mutation changing wetness into drought. Moreover, drought shows an increasing trend. Dryly and wetly climatic boundary shows the fluctuation characteristics of the whole movement and the different fluctuations in East, West, South and North directions. The fluctuation of climatic boundary and the dry and wet variations of climate have 10 distinctive inter-annual features. It was drier in the 1950s, 1970s and 1990s in Southwest China, the eastern part of Northwest China (except Hexi region) and the first region in North China. It was wetter in the 1960s and 1980s.
A Convex Relaxation for Multi-Graph Matching

We present a convex relaxation for the multi-graph matching problem. Our formulation allows for partial pairwise matchings, guarantees cycle consistency, and our objective incorporates both linear and quadratic costs. Moreover, we also present an extension to higher-order costs. In order to solve the convex relaxation we employ a message passing algorithm that optimizes the dual problem. We experimentally compare our algorithm on established benchmark problems from computer vision, as well as on large problems from biological image analysis, the size of which exceed previously investigated multi-graph matching instances.
The cost of illness and economic burden of endometriosis and chronic pelvic pain in Australia: A national online survey

Introduction Endometriosis has a significant cost of illness burden in Europe, UK and the USA, with the majority of costs coming from reductions in productivity. However, information is scarce on if there is a differing impact between endometriosis and other causes of chronic pelvic pain, and if there are modifiable factors, such as pain severity, that may be significant contributors to the overall burden. Methods An online survey was hosted by SurveyMonkey and the link was active between February to April 2017. Women aged 18–45, currently living in Australia, who had either a confirmed diagnosis of endometriosis via laparoscopy or chronic pelvic pain without a diagnosis of endometriosis were included. The retrospective component of the WERF EndoCost tool was used to determine direct healthcare costs, direct non-healthcare costs (carers) and indirect costs due to productivity loss. Estimates were extrapolated to the Australian population using published prevalence estimates. Results 407 valid responses were received. The cost of illness burden was significant in women with chronic pelvic pain (Int $16,970 to $ 20,898 per woman per year) irrespective of whether they had a diagnosis of endometriosis. The majority of costs (75–84%) were due to productivity loss. Both absolute and relative productivity costs in Australia were higher than previous estimates based on data from Europe, UK and USA. Pain scores showed the strongest relationship to productivity costs, a 12.5-fold increase in costs between minimal to severe pain. The total economic burden per year in Australia in the reproductive aged population (at 10% prevalence) was 6.50 billion Int $. Conclusion Similar to studies in European, British and American populations, productivity costs are the greatest contributor to overall costs. Given pain is the most significant contributor, priority should be given to improving pain control in women with pelvic pain
Genetic diversity and population structure of Culex modestus across Europe: does recent appearance in the United Kingdom reveal a tendency for geographical spread?

In mainland Europe, the mosquito species Culex modestus Ficalbi (1890) is a bridge vector for West Nile virus (WNV) from its natural bird‐mosquito cycle to mammals. The present study assessed the genetic diversity of Cx. modestus, as well as related Culex species, using the mitochondrial COI DNA barcoding region and compared this with the population structure across Europe. A haplotype network was mapped to determine genealogical relationships among specimens. The intraspecific genetic diversity within individual Culex species was below 2%, whereas the interspecific genetic divergence varied from 2.99% to 13.74%. In total, 76 haplotypes were identified among 198 sequences. A median‐joining network determined from 198 COI sequences identified two major lineages that were separated by at least four mutation steps. A high level of intraspecific genetic diversity was not detected in Cx. modestus in samples submitted from different European populations, which indicates that morphologically identified specimens represent a single species and not a species complex. Therefore, it is deduced that different populations of Cx. modestus will show a similar potential to transmit WNV, lending support to concerns that the population present in southeast England represents a risk of transmission to humans.
Spironolactone therapy for hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterised by recurrent nodules, abscesses and sinus tract formation. Follicular occlusion is central to lesion development.1,2 Androgens may play a role through increased proliferation of follicular keratinocytes.3 There have been reports of successful treatment of HS with anti-androgen therapies.
Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease

Introduction Patients suffering from Sickle Cell Disease (SCD) are at increased risk for complications due to influenza virus. Annual influenza vaccination is strongly recommended but few clinical studies have assessed its immunogenicity in individuals with SCD. The aim of this study was to explore the biological efficacy of annual influenza vaccination in SCD patients by characterizing both their humoral and cell-mediated immunity against influenza antigen. We also aimed to investigate these immunological responses among SCD individuals according to their treatment (hydroxyurea (HU), chronic blood transfusions (CT), both HU and CT or none of them). Methods Seventy-two SCD patients (49 receiving HU, 9 on CT, 7 with both and 7 without treatment) and 30 healthy controls were included in the study. All subjects received the tetravalent influenza α-RIX-Tetra® vaccine from the 2016–2017 or 2017–2018 season. Results Protective anti-influenza HAI titers were obtained for the majority of SCD patients one month after vaccination but seroconversion rates in patient groups were strongly decreased compared to controls. Immune cell counts, particularly cellular memory including memory T and memory B cells, were greatly reduced in SCD individuals. Functional activation assays confirmed a poorer CD8+ T cell memory. We also document an imbalance of cytokines after influenza vaccination in SCD individuals with an INFγ/IL-10 ratio (Th1-type/Treg-type response) significantly lower in the SCD cohort. Conclusion SCD patients undergoing CT showed altered immune regulation as compared to other treatment subgroups. Altogether, the cytokine imbalance, the high regulatory T cell levels and the low memory lymphocyte subset levels observed in the SCD cohort, namely for those on CT, suggest a poor ability of SCD patients to fight against influenza infection. Nevertheless, our serological data support current clinical practice for annual influenza vaccination, though immunogenicity to other vaccines involving immunological memory might be hampered in SCD patients and should be further investigated.
Sodium citrate ingestion protocol impacts induced alkalosis, gastrointestinal symptoms, and palatability

To compare the effect of 500 mg·kg−1 body mass (BM) sodium citrate ingested in solution or capsules on induced alkalosis, gastrointestinal symptoms and palatability. Twenty‐four healthy and active participants completed two testing sessions, ingesting 500 mg·kg−1 BM sodium citrate within solution or capsules. Capillary blood samples were collected pre‐ingestion, and every 30‐min for 240‐min post‐ingestion; samples were analyzed for blood pH and [HCO3−]. A validated questionnaire was used to quantify gastrointestinal symptoms at the same 30‐min intervals. Palatability was quantified immediately after ingestion using a validated scale. There was a greater peak and change from baseline for capsules versus solution for blood pH (P < 0.001) and [HCO3−] (P = 0.013). Blood pH and [HCO3−] time to peak was 199 and 204 min, respectively, after capsule ingestion, both significantly later than after solution (P = 0.034, P = 0.001). Gastrointestinal symptoms were significantly elevated above baseline for both ingestion modes at each time point between 30 and 120 min after ingestion (P = 0.003), with no differences between modes at any time point (P = 0.644). Capsules were significantly more palatable than solution (P < 0.001). We recommend 500 mg·kg−1 BM sodium citrate ingestion in capsules, at least 200 min before exercise, to achieve greater alkalosis, minimize gastrointestinal symptoms, and maximize.
miR-342-5p inhibits osteosarcoma cell growth, migration, invasion, and sensitivity to Doxorubicin through targeting Wnt7b

ABSTRACT Osteosarcoma (OS) accounts for 9 percent of cancer-related deaths in young people. The PI3K/Akt signaling, a well-known carcinogenic signaling pathway in human cancer, cooperates with other signaling pathways such as Wnt signaling to promote cancer progression. Wnt7b, as a transforming member of the Wnt family, could activate mTORC1 through PI3K-AKT signaling and is upregulated in OS. In the present study, we found that miR-342-5p inhibits Wnt7b expression via direct binding to Wnt7b 3′-UTR. miR-342-5p overexpression remarkably suppressed the viability and invasion while enhanced the apoptosis of OS cells; meanwhile, Wnt7b, β-catenin, c-myc, and cyclin D1 proteins were reduced while E-cadherin protein showed to be increased. Consistent with its expression pattern, Wnt7b exerted oncogenic effects on OS cells. Wnt7b could significantly attenuate the impacts of miR-342-5p. In conclusion, we demonstrated a miR-342-5p/Wnt7b axis that regulates the capacity of OS cells to proliferate and to invade through Wnt/β-catenin signaling. The miR-342-5p/Wnt7b axis might be novel targets for OS targeted therapy, which needs further in vivo and clinical investigations.
The Effect of Social Communication on Life Satisfaction among the Rural Elderly: A Moderated Mediation Model

Life satisfaction of the rural elderly has increasingly become an important issue for society. Based on the social support theory and Cha Xu Ge Ju (pattern of difference sequence), this study investigates the underlying mechanisms and boundary conditions that explain the relationship between social communication and life satisfaction among the rural elderly. Specifically, it explores the mediating role of psychological well-being in the relationship between social communication and life satisfaction. In addition, it examines whether emotional support moderates the effect of social communication on psychological well-being. Data from 658 rural elderly in China were analyzed using structural equation modeling. Results show that psychological well-being mediates the relationship between social communication and life satisfaction. Additionally, the relationship between social communication on psychological well-being was negatively moderated by emotional support. Finally, implications for management theory and practice are discussed.
Role of pyrophosphate on the degradation of sulfamethoxazole by permanganate combined with different reductants: Positive or negative

Activating permanganate with reductants has gained increasing attention recently for efficient organic contaminants abatement via reactive intermediate Mn species. However, few studies have been conducted to explore the role of pyrophosphate (PP), a typical complexing agent for intermediate Mn species, in activated permanganate systems. In this study, taking sulfamethoxazole (SMX) as a probe compound, the influences of PP on SMX degradation by permanganate/thiosulfate and permanganate/hydroxylamine were extensively studied. It was found that both thiosulfate and hydroxylamine were able to activate permanganate for oxidation of SMX in the absence of PP. However, upon the introduction of PP, opposite effects were observed in the two systems where PP further improved the activation of permanganate by thiosulfate but dampened the performance of permanganate/hydroxylamine markedly. For permanganate/hydroxylamine system, MnO2 was determined to be the only reactive oxidative species accounting for SMX degradation in the absence of PP, and its generation could be completely inhibited by PP. While in permanganate/thiosulfate system, both Mn(V) and MnO2 were responsible for SMX oxidation, and the introduction of PP could strengthen the oxidative ability of Mn(V). These results could shed some insights on the suitability of applying PP to explore the kinetics and mechanisms of manganese involved redox reactions.
Predicting translational progress in biomedical research

Fundamental scientific advances can take decades to translate into improvements in human health. Shortening this interval would increase the rate at which scientific discoveries lead to successful treatment of human disease. One way to accomplish this would be to identify which advances in knowledge are most likely to translate into clinical research. Toward that end, we built a machine learning system that detects whether a paper is likely to be cited by a future clinical trial or guideline. Despite the noisiness of citation dynamics, as little as 2 years of postpublication data yield accurate predictions about a paper’s eventual citation by a clinical article (accuracy = 84%, F1 score = 0.56; compared to 19% accuracy by chance). We found that distinct knowledge flow trajectories are linked to papers that either succeed or fail to influence clinical research. Translational progress in biomedicine can therefore be assessed and predicted in real time based on information conveyed by the scientific community’s early reaction to a paper.
Cognitive reserve-mediated neural modulation of emotional control and regulation in people with late-life depression

Abstract Late-life depression (LLD) is an affective disorder that is highly prevalent among older people. Cognitive reserve (CR) refers to an active process that facilitates the flexibility and efficiency of the neural networks to compensate for impairments that emerge in consequence of brain pathology. The current functional magnetic resonance imaging study investigated whether and how CR affects emotional regulation, level of depression severity and neural activity associated with affective control during emotional Stroop (eStroop) task. Altogether, 90 older people participated in this study, 50 of whom suffered from LLD. We used years of education and verbal fluency capacity as proxies for CR. Clinical participants with relatively higher CR presented with milder degrees of depression, better eStroop performance and stronger neural activity in the middle frontal gyrus (MFG) involved with exercising affective control. Results of the mediation analysis indicated that both education and verbal fluency significantly mediated the association between the depression severity and MEG activity. These results suggest a negative association between CR and age-related clinical symptoms of emotional dysregulation. Our neurobehavioral findings provide supportive evidence that CR implies efficiency of top-down emotional regulation and operates as a protective factor against emotional and cognitive vulnerability in the aging brain.
Queer space and alternate queer geographies: LBQ women and the search for sexual partners at two LGBTQ-friendly U.S. universities

Abstract The postgay era – marked by decreased stigmatization of non-heterosexual identities and increasing assimilation of gays and lesbians into the heterosexual mainstream – may be indicative of a broader pluralization of queer geographies expanding the social and sexual opportunities of lesbian, gay, bisexual, transgender, and queer (LGBTQ)-identified individuals beyond queer spaces. Less is known, however, about how LBQ women experience these pluralized geographies in a postgay era in their search for sexual partners, and how the perceived accessibility of queer and heterosexual spaces informs the search process. Drawing upon twenty-six in-depth qualitative interviews, this study examines queer-identified undergraduate women’s searches for same-sex sexual partners at two LGBTQ-friendly universities in the United States. The women in this study described experiences with dating, sex and relationships within three distinct campus “sexual geographies” – queer spaces, virtual communities and heteronormative campus parties – with entry to each of these sites negotiated in relationship to place-based gender and sexual dynamics. While women at both schools viewed their LGBTQ communities as viable spaces to both build community and meet potential sexual partners, this was paired with the understanding that one needed sufficient “queer capital” to stake a claim there. Counter to the notion that a postgay era has rendered queer space obsolete, or just one of many options, this study suggests that perceptions of queer community spaces as exclusionary or inaccessible may partially contribute to the production of alternative queer geographies beyond marked LGBTQ campus spaces.
Association of Neurocognitive and Physical Function With Gait Speed in Midlife

Key Points Question Is gait speed measured at age 45 years associated with accelerated biological aging, neurocognitive function, and cognitive decline? Findings In this 5-decade cohort study of 904 participants in New Zealand, physical and biological indicators of accelerated aging, including compromised brain integrity (eg, reduced brain volume and cortical thickness), were associated with slow gait measured at age 45 years. Lifelong compromised brain health—including poor neurocognitive functioning as early as age 3 years and childhood-to-adulthood decline in cognitive functioning—was associated with slower gait at midlife. Meaning Gait speed at midlife may be a summary index of lifelong aging with possible origins in childhood central nervous system deficits.
Nematicidal Activities of Three Naphthoquinones against the Pine Wood Nematode, Bursaphelenchus xylophilus

Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle, is a serious forest pest, causing enormous economic losses in pine trees in Korea, China, Japan, and countries in Western Europe. To prevent pine wilt disease (PWD), trunk injection with nematicide is performed in Korea. Although these nematicidal agents are quite efficient, the development of new nematicidal agents is needed to prevent pesticide resistance and reduce pest management costs. The aim of this study was to investigate nematicidal activities of pure naphthoquinones (NTQs)–1,4-NTQ, juglone, and plumbagin—against B. xylophilus via in vitro and semi-in vivo assays to identify new candidate agents for trunk injection. Estimated LC50 values (48 h exposure) were 100.0 ppm, 57.0 ppm, and 104.0 ppm for 1,4-NTQ, juglone, and plumbagin, respectively. In the semi-in vivo assay on pine bolt of the Japanese black pine, Pinus thunbergii, the population of inoculated B. xylophilus was significantly decreased at two weeks after treatment with juglone when compared with the effects of treatment with 1,4-NTQ and plumbagin. We also observed that naphthoquinones could generate reactive oxygen species, which presumably indicated that naphthoquinones caused significant oxidative stress in B. xylophilus. The findings of this study suggest the nematicidal potential of naphthoquinones and their possible use in further in vivo assays to test their nematicidal efficacy against B. xylophilus when injected through trunk injection.
Chitin deacetylases Cod4 and Cod7 are involved in polar growth of Aspergillus fumigatus

Chitin is one of the key components of fungal cell wall, and chitin deacetylases (CDAs) have been found in fungi; however, their functions remain unknown. Aspergillus fumigatus is known to cause fatal invasive aspergillosis (IA) among immunocompromised patients with a high mortality rate. Although the A. fumigatus cell wall has long been taken as a unique target for drug development, its dynamic remodeling is complicated and not well understood. Seven putative CDAs are annotated in the A. fumigatus genome. In this study, we analyzed the function of the putative CDAs, Cod4 and Cod7, in A. fumigatus. Biochemical analysis of recombinant proteins showed that Cod4 preferentially deacetylated (GlcNAc)4 and was less active on chitooligosaccharides with DP > 5, whereas Cod7 was unable to catalyze deacetylation. Simulation of three‐dimensional structure revealed that both Cod4 and Cod7 shared a similar folding pattern with HyPgdA from Helicobacter pylori and, similar to HyPgdA, a substitution of Thr8 by Ala8 in Cod7 abolished its CDA activity. Deletion of the cod4, cod7, or both in A. fumigatus led to polarity abnormality and increased conidiation. Furthermore, the expression level of the genes related to polarity was upregulated in the mutants. Our results demonstrated that Cod4 and Cod7 were involved in polarity, though Cod4 was inactive.