Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Nucleophosmin Gene Mutation in Leukemogenesis of Acute Myeloid Leukemia

Background Acute myeloid leukemia (AML) is a hematopoietic stem cell disorder that carries very poor prognosis. Understanding molecular basis of AML leukemogenesis could lead to the emergence of effective targeted therapies for AML. AML bearing nucleophosmin (NPM) gene mutation has distinct features. This study was conducted to investigate the role of mutated (m) NPM in pathogenesis of de novo AML through studying its contribution in proliferation of AML cell line cells. Methods Two types of human leukemia cell lines were used. One of them was a model for AMLs with mNPM and the other for AMLs with wild type (wt) NPM. Assessment of the proliferative role of mNPM in AML was carried out using cell culture and viability studies. The obtained results were reaffirmed by immunocytochemical and immunoblotting techniques. Results Analysis of results was done with the appropriate computer software. It showed higher proliferative potential of cells with mNPM compared to those bearing wtNPM only. Furthermore, the immunocytochemical studies demonstrated subcellular localization of NPM isoforms during various phases of mitosis. Mitosis was associated with cytoplasmic translocation of wtNPM in certain phases, while localization of mNPM remained unchanged throughout the cell cycle. Results of immunoblotting showed little or no change in protein expression of either NPM moieties during mitosis. Conclusions The current study demonstrated important contribution of NPM gene mutation in enhancing proliferation of AML cell lines. These results confirmed the role of mNPM in AML leukemogenesis, and highlighted the importance of targeting mNPM in new evolving AML therapies.
Heavy metal concentration in selected fish species from Eleyele reservoir Ibadan Oyo State South-western Nigeria

Heavy metal concentrations (lead, cadmium, zinc, copper, chromium and manganese) in selected fish species from Eleyele reservoir Ibadan Oyo State South-Western Nigeria were investigated. A sample each of catfish (Clarias gariepinus), Africa pike (Hepsetus odoe) and tilapia fish (Oreochromis niloticus) from Eleyele lake Ibadan Oyo state were collected from fish farmers at the landing site early in the morning using standard procedure and transported to the laboratory within 30 minutes for laboratory analysis. Heavy metal concentration in the flesh of the fish species and water sample were analysed using atomic absorption spectrophotometer. There existed significant difference (p<0.05) in the concentration of heavy metals in fish flesh of various fish species with that of herbivorous fish (Tilapia fish) being the highest followed by omnivorous fish (catfish), followed by piscivorous fish (H. odoe), while that of the water body was the lowest. It was concluded that fish could be considered bio-indicator of environmental contamination within the aquatic ecosystem; it also indicates that fish could be useful in estimating bioavailability of metal to freshwater biota. Key words: Heavy and trace metal, Clarias gariepinus, Hepsetus odoe, Oreochromis niloticus, Eleyele reservoir.
Trade Note September 24 , 2004 Mexican Corn : The Effects of NAFTA

One controversial aspect of the North American Free Trade Agreement (NAFTA) is its impact on Mexican agriculture, particularly on poor corn farmers. Several policy advocacy groups have argued that NAFTA has further impoverished Mexico’s poor farmers. For example, Audley et al (2004) argue that NAFTA can be blamed for the loss of hundreds of thousands of agricultural jobs in Mexico, and Oxfam (2003) states that NAFTA allowed US agricultural subsidies to impoverish Mexican corn farmers. Yet neither of these reports have analyzed the most basic mechanism through which trade liberalization is supposed to affect domestic producers -its effect on domestic producer prices. Few studies have asked the key question: Did removing restrictions on maize imports suddenly drive down the producer price of Mexican corn toward the cheaper US export price?
Bioaccumulation of Xenobiotics Compound of Pesticides in Riverine System and Its Control Technique: A Critical Review

The intensive use of pesticides resulted in dispersal and persistence of pollutants throughout the global environment. Pesticides contamination in river fish, sediments and water ecosystem has become one of the most sensational issues due to their deleterious effect on public health and environment. In natural habitat, certain microbes are capable of metabolizing those persistent compounds or detoxify them which could be employed for bio-remediation. The direct use of different control technique of pesticides, like chemical, biological, mechanical, trapping, cultural and sanitation etc., such microorganisms are capable of degrading xenobiotics is also becoming a popular approach to safeguard the environment. The review paper focused on riverine ecosystem contamination and their control technique of the impacts and focus of the organocholorine pesticides in fish tissues
Late Miocene horned rhinoceroses (Rhinocerotinae, Mammlia) from Kerassia (Euboea, Greece)

Recent systematic excavations near the village of Kerassia (Northern Euboea) have yielded a diverse mamm al fauna of Late Miocene age. Among the most complete and prominent findings are a juvenile skull and an adult mandible that belong to two different homed rhinoceros species. The juvenile skull from the site Kerassia-3 (K3) is assigned to Ceratotherium neumayri, while the adult mandible from the plausibly isochronous site Kerassia-4 (K4) belongs to Dihoplus pikermiensis. These new specimens are compared with the known Eastern Medi­ terranean rhinocerotid record, which is briefly reviewed and updated. The potential interspecific interaction of both species is discussed. Most Eastern Mediterranean localities have yielded only one tandem-homed rhino. In localities with ample material (Pikermi, Samos ), where both species are present, one of them is more abundant, signifying a clear interspecific dominance. D. pikermiensis must have preferred temperate forested habitats, whereas the more specialized C. neumayri more open habitats. For the cases of sympatry, a marked resource partitioning is suggested, not excluding some territorial interaction by water resources or at the boundaries of mixed habitats. A partial dietary competition in these eases cannot be excluded, as well.
Evidence for Dynamically Driven Formation of the GW170817 Neutron Star Binary in NGC 4993

We present a study of NGC 4993, the host galaxy of the GW170817 gravitational-wave event, the GRB 170817A short gamma-ray burst (sGRB), and the AT 2017gfo kilonova. We use Dark Energy Camera imaging, AAT spectra, and publicly available data, relating our findings to binary neutron star (BNS) formation scenarios and merger delay timescales. NGC 4993 is a nearby early-type galaxy, with an i-band Sérsic index n = 4.0 and low asymmetry (A = 0.04 ± 0.01). These properties are unusual for sGRB hosts. However, NGC 4993 presents shell-like structures and dust lanes indicative of a recent galaxy merger, with the optical transient located close to a shell. We constrain the star formation history (SFH) of the galaxy assuming that the galaxy merger produced a star formation burst, but find little to no ongoing star formation in either spatially resolved broadband SED or spectral fitting. We use the best-fit SFH to estimate the BNS merger rate in this type of galaxy, as . If star formation is the only considered BNS formation scenario, the expected number of BNS mergers from early-type galaxies detectable with LIGO during its first two observing seasons is , as opposed to ∼0.5 from all galaxy types. Hypothesizing that the binary formed due to dynamical interactions during the galaxy merger, the subsequent time elapsed can constrain the delay time of the BNS coalescence. By using velocity dispersion estimates and the position of the shells, we find that the galaxy merger occurred tmer ≲ 200 Myr prior to the BNS coalescence.
Giant Anteater (Myrmecophaga tridactyla Linnaeus, 1758) of the brazilian cerrado: hematology and storage effect

Oliveira E. , Trentin T.C. , Vila L.G. , Silva S.L. , Arhnold E. & Martins D.B. 2017. Giant Anteater (Myrmecophaga tridactyla Linnaeus, 1758) of the brazilian cerrado: hematology and storage effect. Pesquisa Veterinária Brasileira 37(7):773-780. Laboratório Clínico Veterinário, Hospital Veterinário, Departamento de Medicina Veterinária, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Rodovia Goiânia Km 8, Campus Samambaia, Goiânia, GO, 74001-970, Brazil. E-mail: vetdanielimartins@yahoo.com. br Giant Anteater (Myrmecophaga tridactyla) is a vulnerable species because of progressive habitat destruction, mostly affected by wildfires and car accidents. The increasing number of animals that are attended by wildlife rescue centres reinforces the need of knowledge about haematological parameters, especially for those that inhabit Brazilian cerrado biome. For this purpose and in order to establish reference values for this species and also to compare them with previous studies, haematological analysis of captive giant anteaters from Brazilian cerrado were performed. Moreover, the alterations of blood samples after 24 and 48 hours of storage at refrigeration temperatures (4oC) and preserved with two different EDTA concentrations (5% and 10%) were studied. Means and standard deviations of haematological parameters analysed immediately after collection were: RBC: 2,07 x106/μL ± 0,40; hematocrit: 38,08%± 5,93; haemoglobin: 11.33g/dL±2.15; MCV:186.52 fL±21.72; MCHC: 29.68g/dL±2.56; MCH: 55.08pcg±5,94; total leucocytes: 8.142/μL±2.441; neutrophils: 5.913/μL±2.168; lymphocytes: 1.460/ μL±740; eosinophil: 522/μL±385; monocytes: 247/μL±176; thrombocytes: 123.458/ μL±31.362 and total plasma protein: 6.23g/dL±0.49. This data shows evidence of the existence of important differences between these values and others from other areas, either from Brazil or from other South American countries. Those variations might be connected to environment, genetic, nutritional and/or management factors. Regarding the storage effect analysis, it can be concluded that in giant anteaters, haematological analysis can be performed until 24h after collection without any significant alterations on the haematological parameters, except for thrombocytes. Concerning the different EDTA concentrations, it can be concluded that there are no quantitative differences in haematological variables. Nevertheless, relevant morphologic alterations in blood cells can be observed after a 24h storage period, being most noticeable in the leucocytes. Those alterations can lead to misinterpretation of the results, interfering diagnosis, prognosis and treatment.
Yield Growth and Fruit Quality of 'Fuerte' and 'Ettinger' Cultivars of Avocado on Four Rootstocks in Cyprus

SUMMARY Yield, tree growth, and fruit quality were measured for 'Fuerte' and 'Ettinger' cultivars of avocado on 'West Indian', 'Duke', 'Topa-Topa', and 'Mexicola' rootstocks. From 1981, when cultivars were 10 years old to 1990, the highest cumulative yield per tree of 'Fuerte' was recorded on 'Mexicola' rootstock and the lowest on 'Duke'; whereas for 'Ettinger', the highest cumulative yield was recorded on 'West Indian' rootstock and the lowest on 'Duke'. The individual fruits of 'Ettinger' were significantly heavier than those of 'Fuerte' on all rootstocks, but in neither cultivar did the rootstock affect mean fruit weight significantly. Although there were some small differences in the percentage of stone and oil content of fruit, these differences were not large enough to likely affect the market value of the fruit. The 'Fuerte' trees were spreading in habit on all rootstocks, whereas 'Ettinger' had an upright growth habit. Trees of both cultivars were most tolerant to lime-induced chlorosis when grown on 'West Indian' rootstock. The avocado, Persea americana Miller, is a relatively new crop in many areas of the world outside its native range in the American subtropics, but it has frequently proved to be a very profitable commercial crop for both local consumption and export. It was brought to Cyprus in 1970 for trials at the southwest coastal part of the island where soil, water, and climatic conditions appeared to be favorable for growing avocado. The first planting was successful and the enterprise started to expand. The area of avocado in 1990 was 134 hectares and avocado production in the same year reached 800t. The performance of two cultivars on four rootstocks for ten years as measured by growth, yield, and quality are presented in this paper.
Informal entrepreneurship and institutional theory: explaining the varying degrees of (in)formalization of entrepreneurs in Pakistan

In recent years, scholars adopting institutional theory have explained the tendency of entrepreneurs to operate in the informal sector to be a result of the asymmetry between formal institutions (the codified laws and regulations) and informal institutions (norms, values and codes of conduct). The aim of this article is to further advance this institutional approach by evaluating the varying degrees of informalization of entrepreneurs and then analysing whether lower levels of formalization are associated with higher levels of institutional asymmetry. To do this, a 2012 survey of the varying degrees of informalization of 300 entrepreneurs in Pakistan is reported. The finding is that 62% of entrepreneurs operate wholly informal enterprises, 31% largely informal and 7% largely formal enterprises. None operate wholly formal enterprises. Those displaying lower levels of formalization are shown to be significantly more likely to display higher levels of institutional asymmetry, exhibiting greater concerns about public sector corruption, possessing lower tax morality and being more concerned about high tax rates and the procedural and distributive injustice and unfairness of the authorities. These entrepreneurs tend to be lower-income, younger and less-educated entrepreneurs. The article concludes by discussing the theoretical and policy implications of these findings.
Study of Physical and Mechanical Properties of Oil Palm Empty Fruit Bunch Fiber Reinforced Polypropylene Composites

Malaysia has about 3.5 million hectares of oil palm producing annually over 10 million tons of crude palm oil (CPO), making it the world’s leading producer of the oil. However, CPO and its economic co-products, palm kernel oil and palm kernel cake, constitute only 10% of the crop, leaving the rest of the biomass to waste. The biomass includes oil palm empty fruit bunch (OPEFB). OPEFB is the residual bunch after removal of the fruits constituting 20% to 22% of the weight of the fresh fruit bunches [1]. Ellis et al. (1994) stated at present, OPEFB is mainly used as mulch. However high transportation cost caused the economics are marginal. It is seldom disposed as burning item (fuel) as the shell and fruit fiber is sufficient for the oil palm [2-4].
Factors Influencing Teachers’ Use of Multimedia Enhanced Content in Secondary Schools in Tanzania

Tanzania is faced with a severe shortage of qualified in-service school science and mathematics teachers. While science and mathematics account for 46% of the curriculum, only 28% of teachers are qualified to teach these subjects. In order to overcome this challenge, the Ministry of Education and Vocational Training (MoEVT) implemented a project to use multimedia-enhanced content to upgrade subject content knowledge of science and mathematics teachers in secondary schools. A total of 70 topics and 147 subtopics were developed and enhanced with various multimedia elements. The content was used to train 2,000 in-service science and mathematics teachers from secondary schools in 19 selected centers countrywide. However, the presence and availability of this content does not automatically guarantee that teachers will use them. For this content to improve teachers’ subject content knowledge, they must be accepted and used by teachers in secondary schools. This study examines factors affecting teachers’ acceptance and prolonged use of developed multimedia-enhanced content using the extended Unified Theory of Acceptance and Use of Technology (UTAUT2) as a research framework. A sample of 1,137 teachers out of 2,000 was collected and tested against the research model using regression analysis. With exception of performance expectancy, all other factors had a statistically significant effect on teachers’ acceptance and use of the developed content. The government and other stakeholders can use these findings to develop strategies that will promote acceptance and use of the developed content in secondary schools in Tanzania.
Effect of Microbial (Jeevatu) Treatment on Rice (Oryza sativa L.) Production

Jeevatu TM is a consortium of beneficial natural microbes, available in liquid form. The yield of rice was observed vigorously high in Jeevatu based rice cultivated plant. The seed production in per spikelet is 237.1±44.92 in Jeevatu based and 179.4±25.26 in chemical based rice plant. In case of vegetative growth, 173.1±6.34 cm and 140.9±11.11 cm in Jeevatu based rice plant and chemical based methods respectively. Similarly the length of stalk of spikelet is 27±1.63cm and 22.1±2.23 cm was observed in Jeevatu based and chemical based respectively. The number of stalk in lumps is 16.2±1.75 and 12.2±2.20 in Jeevatu and chemical based paddy plant respectively under the same environment and physical factors. DOI: http://dx.doi. org/10.3126/ijasbt.v1i4. 9134 Int J Appl Sci Biotechnol, Vol. 1(4): 184-188
Effect of Medium of Instruction on Self-Efficacy: A Study of PMT/PET Course Aspirants

The study examined the effect of medium of instruction (Hindi and English) among PMT/PET course aspirants on Self efficacy. A total of 120 respondents were participated in this study. Furthermore, results revealed that the interaction effect was significant for self-efficacy. Overall, the results seem to be representing higher level of self-efficacy among engineering students than the medical students. In addition, results of medium of instructions clearly indicate higher level of self-efficacy among English instructed students as compared to Hindi medium students.
Genotypic diversity and clonal structure of Erigeron annuus (Asteraceae) in Lithuania

This study was conducted to assess the clonal structure and genetic diversity of alien herbaceous plant species Erigeron annuus. The global warming and changes in agriculture practice in the past few decades were favourable for the expansion of this species in Lithuania. We used RAPD and ISSR assays to assess genetic variation within and among 29 populations of E. annuus. A total of 278 molecular markers were revealed. Our study detected reduced level of genetic diversity of invasive populations of E. annuus. Significant differences in DNA polymorphism among populations of E. annuus were also found. Some populations of this species are composed of genetically identical plants, while others were polymorphic. Clonal diversity of study populations ranged from 0.083 to 0.4 for both DNA marker systems. The Simpsons diversity index values ranged from 0.0 to 0.636. The average number of genotypes per population established using both assays was about 1.7. Out of 328 E. annuus individuals only 16 showed unique RAPD and 14 unique ISSR banding patterns. The remaining plants were clones of different size. The most common genotype of E. annuus identified in our study was represented by predominate in nine populations.Keywords: Clonal structure, DNA markers, Erigeron annuus, invasive plants, ISSR, RAPDGenetische Vielfalt und Klonstruktur von Erigeron annuus (Asteraceae) in LitauenZusammenfassungDie Untersuchungen verfolgen das Ziel, die genetische Struktur der nicht-einheimischen Pflanzenart Erigeron annuus auszuwerten. Globale Erwarmung sowie Veranderungen in der landwirtschaftlichen Praxis der letzten Jahrzehnte waren bedeutsam fur die Verbreitung dieser Art in Litauen. Fur die Feststellung der genetischen Verteilungsvielfalt in den 29 E. annuus Populationen haben wir uns der RAPD und ISSR -Methoden bedient. Insgesamt wurden 117 RAPD - und 161 ISSR - Loci festgestellt. Die Untersuchungen haben die verringerte genetische Vielfalt der E. annuus Populationen aufgezeigt. Auserdem wurden bedeutende DNR polymorphe Unterschiede zwischen E. annuus Populationen angetroffen. Einige Populationen dieser Art bestanden aus genetisch identischen Pflanzen, wahrend die anderen polymorphem waren. Die Klonvielfalt der untersuchten Populationen schwankte zwischen 0.083 und 0.4 bei der Verwendung von beiden DNR-Signifikanten. Die durchschnittliche Genotypen Zahl in der Population betrug etwa 1.7 bei der Verwendung von beiden Signifikanten. Nach der Untersuchung der 328 E. annuus Individuen wurden 16 unikale RAPD - und 14 unikale ISSR - Phanotypen festgestellt. Die ubriggebliebenen Pflanzen waren Klonen von unterschiedlicher Grose. Der am meisten verbreitete E. annuus Genotyp wurde in neun Populationen ermittelt.Stichworter: DNS- Marker, Erigeron annuus, ISSR, Klonstruktur, invasive Pflanzen, RAPD
Strategies for a successful plant invasion: the reproduction of Phragmites australis in north‐eastern North America

Knowing the relative contribution of vegetative propagation and sexual reproduction to the dispersal and establishment of exotic plants is crucial for devising efficient control strategies. This is particularly true for the common reed (Phragmites australis), one of the most invasive species in North America. For the first time, we combined in situ field observations and genetic evidence, based on two genotyping techniques, that is microsatellite markers (SSR) and genotyping by sequencing (GBS), to determine the propagation strategies of this invader at its northern distribution limit in North America and especially in roadside ditches. Field observations revealed that, in a region where the common reed is already abundant, both seeds and plant fragments contributed to the establishment of new populations. Newly established individuals originated mostly (84%) from seeds rather than fragments, but a larger proportion of individuals originating from fragments survived the second year compared to seedlings. High genetic diversity among marsh and roadside common reed stands indicated the prime role of sexual reproduction for dispersal. The vast majority of genotypes were found in only one stand; such high genetic variability can only be explained by sexual reproduction. Half the surveyed stands comprised a single clone, suggesting that local expansion mainly occurred vegetatively. As the small proportion of SSR genotypes initially thought to be common between distant stands proved to be distinct (as revealed by GBS data), it is likely that all the stands examined were initially founded by genetically distinct individuals. Synthesis. Our study suggests that long‐distance dispersal by seeds is important for the common reed, in marshes and roadsides, while both seeds and plant fragments contribute to short‐distance dispersal along roads, at least in regions where the species is already abundant. The success of this invader in North America seems to be attributable to a reproduction strategy combining the advantages of sexuality with those of vegetative propagation. Moreover, this study shows that the GBS approach strongly reduces uncertainties associated with the use of a limited number of markers. This approach is especially valuable for ecologists dealing with an ever‐increasing number of invaders, of which few have identified microsatellite markers.
Modified Two-Slit Experiments and Complementarity

Some modified two-slit interference experiments claim to demonstrate a violation of Bohr’s complementarity principle. A typical such experiment is theoretically analyzed using wave-packet dynamics. The flaw in the analysis of such experiments is pointed out and it is demonstrated that they do not violate complementarity. In addition, it is quite generally proved that if the state of a particle is such that the modulus square of the wave-function yields an interference pattern, then it necessarily loses which-path information.