Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship between the expression of iNOS,VEGF,tumor angiogenesis and gastric cancer.

AIM To investigate the relationship between the expression of inducible nitric oxide synthase(iNOS),vascular endothelial growth factor(VEGF),the microvascular density (MVD) and the pathological features and clinical staging of gastric cancer. METHODS Immunohistochemical staining was used for detecting the expression of iNOS and VEGF in 46 resected specimens of gastric carcinoma; the monoclonal antibody against CD34 was used for displaying vascular endothelial cells, and MVD was detected by counting of CD34-positive vascular endothelial cells. RESULTS Of 46 resected specimens of gastric carcinoma,the rates of expressions of iNOS and VEGF were 58.70% and 76.09%, respectively,and MVD averaged 55.59+/-19.39. Judged by the standard TNM criteria, the rate of expression of iNOS in stage IV (84.46%) was higher than those in stage I,II, III(Fish exact probabilities test, P=0.019,0.023 and 0.033,respectively);the rates of expression of VEGF in stage III,IV (76.0%,92.31%,respectively) were higher than those in stage I,II (Fish exact probabilities test, P=0.031,0.017,0.022 and 0.019). MVDs in stage III,IV(64.72+/-14.96,67.09+/-18.29,respectively) were higher than those in stage I,II(t=2.378,4.015,2.503 and 2.450, P<0.05,P<0.001,P<0.001, P<0.05,respectively). In 37 gastric carcinoma specimens with lymph node metastasis, MVD(68.69+/-18.07) and the rates of expression of iNOS and VEGF(70.27%,83.78%,respectively) were higher than those in the specimens with absence of metastasis (t=2.205, chi(2)=6.3587, chi(2)=6.2584, P<0.01, P<0.05, P<0.05, respectively). MVD and the expressions of iNOS and VEGF were not correlated to the location,size or grade of tumor,nor with the depth of invasion of tumor; MVDs in the positive iNOS and VEGF specimens(59.88+/-18.02,58.39+/-17.73, respectively) were higher than those in the negative iNOS and VEGF specimens (chi(2)=6.3587 and 6.1574, P<0.05, P<0.05,respectively);thus the expressions of iNOS and VEGF was correlated to MVD,but the expression of iNOS was not correlated to that of VEGF. In addition,of the 46 surviving patients, the 5-year survival rate of patients with positive iNOS or VEGF tumors was significantly less than that of patients with negative iNOS-or VEGF tumors(chi(2)=4.3842 and 5.4073, P<0.05, P<0.05, respectively). CONCLUSION The expressions of iNOS and VEGF are closely related to tumor angiogenesis,and are involved in the advancement and the lymph node metastasis; thus MVD and the expressions of iNOS and VEGF may serve indexes for evaluating staging of gastric carcinoma and forecasting its risk of metastasis, which will help establish a comprehensive therapeutical measure of post-operative patients and provide a new approach to tumor therapy.
Skeletal muscle vasodilatation during maximal exercise in health and disease

Abstract Maximal exercise vasodilatation results from the balance between vasoconstricting and vasodilating signals combined with the vascular reactivity to these signals. During maximal exercise with a small muscle mass the skeletal muscle vascular bed is fully vasodilated. During maximal whole body exercise, however, vasodilatation is restrained by the sympathetic system. This is necessary to avoid hypotension since the maximal vascular conductance of the musculature exceeds the maximal pumping capacity of the heart. Endurance training and high‐intensity intermittent knee extension training increase the capacity for maximal exercise vasodilatation by 20–30%, mainly due to an enhanced vasodilatory capacity, as maximal exercise perfusion pressure changes little with training. The increase in maximal exercise vascular conductance is to a large extent explained by skeletal muscle hypertrophy and vascular remodelling. The vasodilatory capacity during maximal exercise is reduced or blunted with ageing, as well as in chronic heart failure patients and chronically hypoxic humans; reduced vasodilatory responsiveness and increased sympathetic activity (and probably, altered sympatholysis) are potential mechanisms accounting for this effect. Pharmacological counteraction of the sympathetic restraint may result in lower perfusion pressure and reduced oxygen extraction by the exercising muscles. However, at the same time fast inhibition of the chemoreflex in maximally exercising humans may result in increased vasodilatation, further confirming a restraining role of the sympathetic nervous system on exercise‐induced vasodilatation. This is likely to be critical for the maintenance of blood pressure in exercising patients with a limited heart pump capacity.
Interpolation in variable Hilbert scales with application to inverse problems

For solving linear ill-posed problems with noisy data, regularization methods are required. In the present paper, regularized approximations in Hilbert scales are obtained by a general regularization scheme. The analysis of such schemes is based on new results for interpolation in Hilbert scales. Error bounds are obtained under general smoothness conditions.
Is there global inclusion of authors in the five leading advertising journals?

A question that has been raised in academia has to do with whether there is global inclusion of authors in publishing. While this issue has been explored in some areas in business and marketing it has generally not been investigated across 30 years of advertising research activity. This paper seeks to examine the global inclusion of authors in five advertising-focused journals. We found that, while there appears to be an increase in international publishing activity in advertising compared to data extrapolated from past studies, published advertising research still reveals a North American bias/domination. A failure to be globally inclusive may lead to an under-exploration of academic issues and perspectives, as important ‘non-US’ issues could possibly be ignored.
Hereditary and familial ovarian cancer in southern ontario

Background. Hereditary ovarian cancer may be site specific or may appear in combination with breast cancer or other cancers in a family. The most common hereditary form is the breast‐ovarian cancer syndrome. It is estimated that in 100% of these families, there is linkage to a cancer susceptibility gene on chromosome 17q, BRCAl.
On the Methodology of Studying Aging in Humans

Abstract : Methods for studying the aging of human beings cover a wide span of scientific endeavor. The literature in the field is large and research is expanding rapidly. Some indication of the scope of research activity on aging is obtained from the following listing of topics found in the 15-page table of contents of Nathan Shock's bibliography of gerontology [39]. (A) Biology of aging (1) cellular biology and physiology, (2) climate and geography,(3) exercise, (4) longevity (comparative physiology, diet, drugs, heredity, marriage, mortality rates, national groups, occupation, sex), (5) metabolism, (6) mortality rates, (7) nutrition, (8) parental age, (9) physiological age, (10) rejuvenation, (B) Organ systems, (C) Geriatrics, (D) Psychological processes, (E) Social and economic aspects. Out of this maze of information and theory a number of lines of thought have been gathered in this paper to focus attention on some biostatistical phases of the enigma of aging. That this is a subject which is eminently biostatistical iR obvious from its nature. Observation and experimentation are carried out all the way from the most basic cellular level up through drosophila, flatworms, rotifers, rats, horses, elephants and man. As one proceeds up the developmental ladder experimentation is replaced by observation and direct knowledge is replaced by indirect inference. At the human level our real understanding of aging is indeed poor, depending as it must on the evidence of vital statistics and hampered by the time required to follow groups of subjects through an appreciable part of their lifetime. A difficulty, not reserved for the problem of aging but particularly nasty in this case, is the lack of specifiability of conditions under which observations are made.
Performance of an industrial biofilter from a composting plant in the removal of ammonia and VOCs after material replacement

BACKGROUND: Biofiltration is a suitable odor reduction technique for the treatment of gaseous emissions from composting processes, but little is known about the start-up of full-scale biofilters after material replacement and their performance after several years of operation. RESULTS: Biofilter material (wood chips used previously as bulking agent in a composting process) can effectively remove ammonia and most of the volatile organic compounds (VOCs) content, achieving removal efficiencies greater than 70% for VOCs and near 90% for ammonia immediately after material replacement. These removal efficiencies were maintained for several months after material replacement. In the studied full-scale biofilter no lag phase was observed in the removal of ammonia whereas in the case of VOCs different patterns were detected during biofilter start-up. For the old biofilter material, after 4 years of operation, a statistically significant decrease of removal efficiency for ammonia in comparison with the new material was detected. No statistically significant differences were found in the case of VOCs. CONCLUSIONS: Data on the emissions of several pollutants from biofilters treating composting exhaust gases have been systematically obtained. The tested filtering media presented adequate properties for biofiltration of gases emitted during the composting process. Copyright © 2009 Society of Chemical Industry
Do Mexican Companies Culturally Adapt Their Websites?

Although some articles have tried to address the standardization/adaptation strategies of companies on the internet, there is still a lack of guidance on the issue, especially for companies outside of the United States. To help alleviate this shortage of guidance and provide Mexican web designers, web marketers, and IT managers with some insights into web cultural adaptation, this article conducted a comparative analysis of Mexican based companies’ domestic websites and their U.S. international websites, replicating a cultural adaptation framework from prior literature. Thirteen Mexican based Bolsa Mexicana de Valores (2005) companies were evaluated to test for the cultural adaptation of their Mexican and international websites. A content analysis of 26 Mexican domestic and U.S. international websites reveals non-significant cultural adaptation on the web; however, the results of the web content analysis are similar to those of previous research, which consider Mexican culture to score high in power distance, uncertainty avoidance, masculinity, and high-context cultural dimensions. However, for the collectivistic dimension, the results were opposite to those of previous research, which may suggest a need to develop and test other cultural adaptation frameworks for future research.
[Diabetic ophthalmoplegia--a clinico-pathological study of the first case in Japan].

Many reports of diabetic ophthalmoplegia have been published from the clinical points of view. However, there have been only three autopsied cases in which the ocular nerves were investigated histopathologically. A 72-year-old housewife was diagnosed to have glycosuria at the age of 67, but no medical treatment was done. She admitted to the hospital, because of acute onset of right eyelid drooping and diplopia for previous four days. She showed complete eyelid ptosis, moderate dilatation of right pupil, loss of light reaction, and extraocular muscle palsy except abduction on the right. Blood pressure was normal. A glucose tolerance test was diabetic and HbA1c was moderately increased. Her diabetes was fairly well-controlled with a diet therapy and injection of lente insulin. Two and a half months after admission, the course of illness became regressive. Seven months later, external ophthalmoplegia was disappeared and only slight anisocoria was seen. She readmitted to the hospital one year and eleven months later, because of anorexia and emaciation. She died of adenocarcinoma of the stomach without chemotherapy. The duration from onset of ocular symptoms to death was two years and one month. At postmortem examination, stomach cancer infiltrated extensively to the abdominal and pelvic viscera, but no metastasis to the nervous system or intraorbital tissues was found. There were mild to moderate atherosclerotic changes in the small-and middle-sized arteries of the kidneys, pancreas and adrenal glands corresponding to her age. Moderate atherosclerosis was found in all of the major arteries including Willis ring, siphon of the right internal carotid artery and Vertebro-basilar one. (ABSTRACT TRUNCATED AT 250 WORDS)
Exploring the Effects of “What” (Product) and “Where” (Website) Characteristics on Online Shopping Behavior

Understanding factors that influence online shopping and managing consumer relationships is not a trivial task for firms, considering the many pertinent factors that influence behavior, including the product being shopped (i.e., the “what”) and the context of the website itself (i.e., the “where”). This study investigates the impact of these characteristics on an online transaction's basket value, after incorporating the role of other aspects of the browsing process including page views and visit duration. The authors estimate a multivariate mixed-effects Type II Tobit model with a system of equations to explain variation in shopping basket value, using data involving 773,262 browsing sessions resulting in 9,664 transactions across 43 product categories from 385 unique websites. The results support the assertions that contextual factors are associated with online browsing. For example, a website's scope in terms of product variety is associated positively with visit durations and basket values but negatively with page views. Furthermore, a website's communication functionality is positively associated with basket value for hedonic products. Insights suggest managerial implications involving product and website strategies for online retailers.
Working Environment and Well-Being: Empirical Evidence from the 5th European Working Condition Survey

The main aim of the paper is the definition of the constructs well-being, demands, resources and flexibility out of an existing and available data set. For this purpose we used the 5th European Working Conditions Survey, the theoretical assumptions from the Job Demands-Resources model (JD-R model) and further theoretical and empirical findings. Thus, we gained more information out of the data structure and the interdependence of the constructs, their dimensions and further explanatory variables as gender, work-life-balance, work-health-attitude, financial ease and type of contract. We also found interesting geographical pattern in the distribution of constructs. Hence, well-being is rather high in the northern part of West Europe and in North Europe. The resources, which affects well-being positive, are high in North Europe, while in South Europe they are low. Interestingly, also high demands with a negative influence on well-being, are found in the northern part of West Europe for the United Kingdom and Ireland. Flexibility is clearly high in North Europe and rather medium in the other countries. Thereby, overall flexibility is neutral concerning well-being, whereas the impact in the individual case can be positive as well as negative. Resources and demands are significant for employees well-being.
Kinetic model of excitatory synaptic transmission to cerebellar Purkinje cells.

We present a minimal kinetic model for excitatory synaptic transmission to cerebellar Purkinje cells. The main components are a kinetic model for a single glutamate receptor, which is calibrated with the help of patch clamp data, and a mean field approximation for the dynamics of a population of channels, which generate an EPSC. The resulting minimal model of the parallel fiber-Purkinje cell synapse is used to estimate the dynamics of glutamate in the synaptic cleft and to clarify the role of receptor desensitization in synaptic transmission. We also apply the model to different aspects of synaptic modulation, like long-term depression and potentiation by pharmacological application of ampakines. In the framework of the minimal model these effects can be understood as the result of modified receptor kinetics.
The semiology of tilt-induced psychogenic pseudosyncope

Objectives: To provide a detailed semiology to aid the clinical recognition of psychogenic pseudosyncope (PPS), which concerns episodes of apparent transient loss of consciousness (TLOC) that mimic syncope. Methods: We analyzed all consecutive tilt-table tests from 2006 to 2012 showing proven PPS, i.e., apparent TLOC had occurred without EEG changes or a decrease in heart rate (HR) or blood pressure (BP). We analyzed baseline characteristics, video data, EEG, ECG, and continuous BP measurements on a 1-second time scale. Data were compared with those of 69 cases of tilt-induced vasovagal syncope (VVS). Results: Of 800 tilt-table tests, 43 (5.4%) resulted in PPS. The majority (74%) were women. The median duration of apparent TLOC was longer in PPS (44 seconds) than in VVS (20 seconds, p < 0.05). During the event, the eyes were closed in 97% in PPS but in only 7% in VVS (p < 0.0001). A sudden head drop or moving down the tilt table was more common in PPS than in VVS (p < 0.01), but jerking movements occurred more frequently in VVS (p < 0.0001). In PPS, both HR and BP increased before and during apparent TLOC (p < 0.0001). Conclusions: PPS is clinically distinct from VVS and can be diagnosed accurately with tilt-table testing and simultaneous EEG monitoring. Compared with VVS, eye closure during the event, long periods of apparent TLOC, and high HR and BP are highly specific for PPS. Improved understanding of the semiology of PPS as a clinical entity is vital to ensure accurate diagnosis.
Excision of Rhinophyma With High‐Frequency Electrosurgery

BACKGROUND Rhinophyma is an uncommon progressive disfiguring process of the lower nasal region that most commonly affects middle-aged white men. It is characterized by painless hyperplasia of the sebaceous and subcutaneous tissues, in the end stage, resulting in a bulbous nodular telangiectatic nose. Surgical modalities of treatment include electrosurgery, laser ablation, dermabrasion, cryosurgery, scalpel excision, and others. OBJECTIVE We present two patients with rhinophyma who were treated with the Ellman Surgitron using high-frequency current. METHODS Two patients with significant rhinophyma and associated subcutaneous abscesses underwent excision with the Ellman Surgitron using high-frequency electrosurgery with a wire loop. The sebaceous hypertrophy was shaved down to the level of the normal skin surface. RESULTS This technique provided a quick, efficient, bloodless operative field with a good cosmetic result and pain-free postoperative recovery. Photographs were taken at regular intervals to document the healing process. CONCLUSION The Ellman Surgitron uses high-frequency current to achieve a bloodless field in the treatment of rhinophyma. This enabled efficient and quick removal of hypertrophied tissue with a good cosmetic result and an essentially pain-free recovery. This radiofrequency device is well suited for the outpatient setting and offers advantages over the other modalities used to treat rhinophyma.
Does supply chain management strategy mediate the association between market orientation and organizational performance

Purpose – The purpose of this research was to examine the link between supply chain management (SCM), market orientation, and organizational success, and to develop a model that describes the relationship among the three.Design/methodology/approach – A survey of sales managers within large US manufacturers was used to collect data about market orientation, SCM strategy, and organizational performance. Five hypotheses were tested using structural equation modeling.Findings – The resulting model suggests that a manufacturing firm's SCM strategy mediates the relationship between its market orientation and organizational success.Research limitations/implications – Perhaps the most serious limitation of this study was its narrow focus on US manufacturing companies, thus precluding the generalization of findings to other sectors such as service and government sectors that may benefit from a market orientation and sound SCM strategy.Practical implications – The study findings reinforce the importance of a market.
Thalamic deactivation at sleep onset precedes that of the cerebral cortex in humans

Thalamic and cortical activities are assumed to be time-locked throughout all vigilance states. Using simultaneous intracortical and intrathalamic recordings, we demonstrate here that the thalamic deactivation occurring at sleep onset most often precedes that of the cortex by several minutes, whereas reactivation of both structures during awakening is synchronized. Delays between thalamus and cortex deactivations can vary from one subject to another when a similar cortical region is considered. In addition, heterogeneity in activity levels throughout the cortical mantle is larger than previously thought during the descent into sleep. Thus, asynchronous thalamo-cortical deactivation while falling asleep probably explains the production of hypnagogic hallucinations by a still-activated cortex and the common self-overestimation of the time needed to fall asleep.
Adaptation to nonstationarity of embedded wavelet code stream

We address a problem that affects the performance of all embedded wavelet image codecs-how to track time varying statistics of the coefficient code stream. We propose a family of techniques for rapid adaptation of arithmetic coding to changing statistics of the wavelet coefficients. These techniques improve the compression performance of existing wavelet image codecs, particularly at high bit rates and for lossless coding.
Earnings Management and Capital Resource Allocation: Evidence from China's Accounting-Based Regulation of Rights Issue

From 1996 to 1998, listed companies in China were required to achieve a minimum return on equity (ROE) of 10 percent in each of the previous three years before they could apply for permission to issue additional shares. Hence, there was a heavy concentration of ROEs in the area of just above 10 percent. This paper shows that earnings management is relatively easy to detect on China's standardized income statement. In the 1996-1998 period, Chinese regulators seem to have gradually increased their scrutiny of earnings management in the approval process, and improved their ability to identify firms that subsequently performed better. However, since this scrutiny was limited, many firms were still able to gain rights issues approval through earnings management. The study shows that these firms subsequently performed worse than those which did not employ such practices. Thus, capital resources might have been allocated better had the regulators examined more closely the management of earnings.