Miracle-dz/UniFAR-FTUs huggingface dataset:
By Ribosome Possessed

“Listen, howwould you like to come on tourwithmynewband? ” BennyWilson asked me in the summer of 1965 duringmy final year of graduate school. A few days later, I received a letter from the National Institutes of Health (NIH) with the news that I had been awarded a three-year fellowship to do postdoctoral research at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge. Benny was an exciting young jazz pianist and blues organist, the son of a Baptist minister in Eugene who transported his Hammond organ to gigs in the back of his elegant blueMercedes 220S Cabriolet. It was a great temptation to join Benny on the road, but there would be scant opportunity to do biochemistry. On the other hand, I guessed that I would findmusicians in Cambridge. That fall, in our final weekend in the Bay Area, my wife and I found ourselves at Ken Kesey’s home in La Honda, where his famous bus “Furthur” was parked in the driveway. We watched hours and hours of raw 16-mm movie footage taken by the Merry Pranksters on their infamous trip, surrounded by hippies and Hells Angels. In the morning, we raced up La Honda Road to Skyline, where we had breakfast with Neal Cassady, at the counter of Alice’s Restaurant in Woodside. Cassady was as vivid as Kerouac had portrayed him as DeanMoriarty inOn the Road.At breakfast, hemaintained a rapid streamof incomprehensible parallel conversations: withme, the person sitting on the other side of him, the waitress, and someone who was not there. Over the next few days, we reluctantly said goodbye to our native culture, crossed the country to New York by train, and boarded a cut-rate Icelandic Airlines propeller flight to London via Keflavik. My postdoctoral adviser, theWelsh protein chemist Ieuan Harris, had booked us a room at the Prince Regent, a nice pub near the middle of Cambridge. On our first morning, I rolled out of bed, took the bus to theMRC, and was greeted by the receptionist with “Oh, Dr. Noller. Let me go find Dr. Perutz! ” I was stunned. Did she mean Nobel laureate Max Perutz, director of the MRC Laboratory ofMolecular Biology and one of the gods ofmolecular biology? I followed her down the hall. She said, “Dr. Perutz is out of his office. Let’s see if he’s in his laboratory. ” Just then, the door of the cold room flew open, and a small baldman in a white coat stepped out, carrying an Erlenmeyer flask containing a red liquid.Max Perutz, founder of the science of protein crystallography, was doing a hemoglobin prep with his own hands. He stopped, smiled modestly, extended a free hand, and welcomed me warmly to the MRC. I was struck by his utter lack of pretention and his generosity in taking time to talk with an obscure postdoctoral fellow on his first day, even as condensation formed on the surface of his Erlenmeyer. I felt very out of place, in way over my head, and very lucky.
The implications of the shift towards services in multinationals' activities: evidence from the Greek case

Greece has been a traditional recipient of Foreign Direct Investment (FDI) since the early 1950s. The country constitutes an excellent example of how a small, open but peripheral economy, gradually changes according to the process of economic development. The paper’s main target is dual: First to provide a comprehensive description of Greece’s position in attracting FDI today and second to explain the location determinants of the structural change in Greek inward foreign investments from manufacturing to services. Whilst in the late eighties, inward investments mainly targeted the manufacturing sector, Greece nowadays attracts primarily FDI in services such as financial intermediation, real estate etc. Traditional factors attracting FDI seem to dominate the international investors’ decisions as well as capital productivity and labour costs on the sectoral level, these are significant influences when investing in Greece. The paper concludes by offering interesting policy implications.
Patterns of objectively measured physical activity in the United States.

PURPOSE We used latent class analysis (LCA) to assess patterns of physical activity among adults, using the 7 d of accelerometer data from the 2003-2004 NHANES. METHODS For each participant, we determined the daily minutes of moderate-to-vigorous physical activity (MVPA), vigorous physical activity (VPA), and minutes of MVPA that occurred in bouts of 10 min. Participants were then categorized into patterns of activity, using LCA and adjusting for sociodemographic characteristics. RESULTS For overall MVPA, five classes of physical activity were defined, including two least active classes, which averaged less than 25 min of MVPA per day and represented 78.7% of the total study population. The most active class averaged 134 min of MVPA per day and comprised 0.9% of the population. The results for bout minutes of MVPA were similar to the patterns produced for overall MVPA, with the exception of a "weekend warrior" class with moderate levels of physical activity Monday through Friday but with a much higher level of activity on the weekend, particularly on Sunday. This class represented 1.8% of the population. Only 1.4% of all days achieved 10 min or more of VPA, and in 91.1% of all days, participants accumulated less than 1 min of VPA. The LCA analysis of VPA did not produce stable results, because of the small number of participants registering any minutes of VPA. CONCLUSION Our results indicate that a very large portion of the U.S. population may be classified into patterns of physical activity that represent low levels of MVPA throughout the week. The LCA analysis provided a novel approach for assessing patterns of objectively measured physical activity in epidemiologic studies.
Improving preclinical decision making with high-content, protein complex- based profi ling of compound selectivity and safety

The past decade has seen major developments in our knowledge of the compendium of genes and proteins. The connections between these components and their roles in complex disease states, however, are poorly understood. It is also apparent that individual signalling events do not refl ect complex cellular responses to external stimuli or drug treatment. High throughput methods for monitoring diverse signaling pathways, and their highly ramifi ed connections and feedback loops, are required to understand target and drug activity within the native cellular context.
Risk of False Positives When Identifying Malingered Profiles Using the Trauma Symptom Inventory

The Trauma Symptom Inventory (TSI; Briere, 1995) is a 100-item self-report measure of posttraumatic symptomatology that includes an Atypical Response (ATR) validity scale designed to differentiate honest from malingered profiles. In this study, using an analogue design to experimentally manipulate honest and malingered responses on the TSI, we found that proposed ATR cut scores produce a significant risk of false positives. Furthermore, the functioning of proposed cut scores worsened when we used posttraumatic stress disorder relevant samples and low estimates of malingering base rates. In light of these findings, the TSI should be used with caution when assessing claims of posttraumatic stress in forensic or disability settings.
Threshold Voltage Tuning of Low-Voltage Organic Thin-Film Transistors

There are two critical issues involved in voltages of organic thin-film transistors (OTFTs), i.e., high operating voltages Vop and random distributed threshold voltages VTH, which lead to high power consumption and unreliable logic function in organic integrated circuits, respectively. This paper demonstrates that both issues can be solved in a single OTFT device by using very thin insulator films. The operating voltages could be reduced to be less than 3 V, without lowering the mobility and the on/off ratio. Using light-enhanced bias stress effect, the threshold voltages can be tuned into the range of -4 to 4 V in OTFTs with SiO2 or Al2O3 as dielectric films, demonstrating that light-enhanced bias stress effect in OTFTs is independent of the dielectric material. The ΔVTH/Vop ratio is about 3, which is one of the largest threshold-voltage-shifting ratios. It is found that the threshold voltage shifting has a linear relationship with the bias voltage and the light illumination time. This tuning technology is a post fabrication and noninvasive method with negligible influence on the mobility and on/off current ratios.
Pentoxifylline therapy in the management of oral submucous fibrosis.

OBJECTIVES Oral submucous fibrosis is a common premalignant condition in the Indian subcontinent and is caused by chewing areca nut and other irritants in various forms. Its medical treatment is not yet fully standardized. In this study we compared the efficacy of Pentoxifylline as compared to placebo. MATERIALS AND METHODS 75 patients suffering from oral submucous fibrosis were randomly divided into two groups A and B. Group A patients received placebo, while Group B patients received 400 mg. Pentoxifylline for a period of 7 months. Treatment outcome was evaluated on the basis of improvement in symptom and sign scores. Student's t test was applied for comparing the results. RESULTS The improvement in total (i.e. symptoms + sign) score was 25% in group A and 49.15% in group B. This difference was found to be statistically significant. (p < 0.05) CONCLUSION Treatment regimen of group B was more effective. No significant side effects were seen. A follow up study is required to assess long term outcome of this therapy.
Ten novel FBN2 mutations in congenital contractural arachnodactyly: Delineation of the molecular pathogenesis and clinical phenotype

Congenital contractural arachnodactyly (CCA) is an autosomal dominant condition that shares skeletal features with Marfan syndrome (MFS), but does not have the ocular and cardiovascular complications that characterize MFS. CCA and MFS result from mutations in highly similar genes, FBN2 and FBN1, respectively. All the identified CCA mutations in FBN2 cluster in a limited region similar to where severe MFS mutations cluster in FBN1, specifically between exons 23 and 34. We screened exons 22 through 36 of FBN2 for mutations in 13 patients with classic CCA by single stranded conformational polymorphism analysis (SSCP) and then by direct sequencing. We successfully identified 10 novel mutations in this critical region of FBN2 in these patients, indicating a mutation detection rate of 75% in this limited region. Interestingly, none of these identified FBN2 mutations alter amino acids in the calcium binding consensus sequence in the EGF‐like domains, whereas many of the FBN1 mutations alter the consensus sequence. Furthermore, analysis of the clinical data of the CCA patients with characterized FBN2 mutation indicate that CCA patients have aortic root dilatation and the vast majority lack evidence of congenital heart disease. These studies have implications for our understanding of the molecular basis of CCA, along with the diagnosis and genetic counseling of CCA patients. Hum Mutat 19:39–48, 2002. © 2001 Wiley‐Liss, Inc.
Hand Hygiene Practices After Brief Encounters With Patients: An Important Opportunity for Prevention

Objective. To identify characteristics of encounters between healthcare workers (HCWs) and patients that correlated with hand hygiene adherence among HCWs. Design. Observational study. Setting. Intensive care unit in a Veterans Affairs hospital. Participants. HCWs. Results. There were 767 patient encounters observed (48.6% involved nurses, 20.6% involved physicians, and 30.8% involved other HCWs); 39.8% of encounters involved patients placed under contact precautions. HCW contact with either the patient or surfaces in the patient's environment occurred during all encounters; direct patient contact occurred during 439 encounters (57.4%), and contact with environmental surfaces occurred during 710 encounters (92.6%). The median duration of encounters was 2 minutes (range, <1 to 51 minutes); 33.6% of encounters lasted 1 minute or less, with no significant occupation-associated differences in the median duration of encounters. Adherence with hand hygiene practices was correlated with the duration of the encounter, with overall adherences of 30.0% after encounters of ≤1 minute, 43.4% after encounters of >1 to ≤2 minutes, 51.1% after encounters of >3 to ≤5 minutes, and 64.9% after encounters of >5 minutes (P < .001 by the x2 for trend). In multivariate analyses, longer encounter duration, contact precautions status, patient contact, and nursing occupation were independently associated with adherence to hand hygiene recommendations. Conclusions. In this study, adherence to hand hygiene practices was lowest after brief patient encounters (ie, <2 minutes). Brief encounters accounted for a substantial proportion of all observed encounters, and opportunities for hand contamination occurred during all brief encounters. Therefore, improving adherence after brief encounters may have an important overall impact on the transmission of healthcare-associated pathogens and may deserve special emphasis in the design of programs to promote adherence to hand hygiene practices.
Life-history traits of the long-nosed skate Dipturus oxyrinchus.

This work investigates life-history traits of the long-nosed skate Dipturus oxyrinchus, which is a common by-catch in Sardinian waters. The reproductive variables were analysed from 979 specimens sampled during scientific and commercial hauls. Females (10·4-117·5 cm total length, LT ) attained larger sizes than males (14·5-99·5 cm LT ). To evaluate age and growth, a sub-sample of 130 individuals (76 females and 54 males) were used. The age was estimated by annuli counts of sectioned vertebral centra. Four models were used for the length-at-age data: the von Bertalanffy, the exponential, the Gompertz and the logistic functions. According to the Akaike's information criterion, the Gompertz model seemed to provide the best fitting curve (L∞ mean ± s.e.: 127·55 ± 4·90 cm, k: 0·14 ± 0·09, IP: 3·97 ± 0·90 years). The oldest female and male were aged 17 (115·5 cm LT ) and 15 years (96·0 cm LT ), respectively. Lengths at maturity were 103·5 cm for females and 91·0 cm for males, corresponding to 90% of the maximum observed length in both sexes. The monthly distribution of maturity stages highlighted an extended reproductive cycle, with spawning females and active males being present almost throughout the year, as confirmed by the gonado-somatic index. Ovarian fecundity reached a maximum of 26 yolked follicles with a mean ± s.e. size of 19·7 ± 6·5 mm.
Urinary levels of monocyte chemoattractant protein‐1 (MCP‐1) and interleukin‐8 (IL‐8), and renal injuries in patients with type 2 diabetic nephropathy

We examined the correlation among the levels of urinary monocyte chemoattractant protein‐1 (MCP‐1) and interleukin‐8 (IL‐8), hyperglycemia, and renal injuries in patients with type 2 diabetic nephropathy. The levels of urinary MCP‐1, IL‐8, protein excretion, blood urea nitrogen (BUN), serum creatinine (s‐Cr), glycohemoglobin A1c (HbA1c), and fasting plasma glucose (FPG) were measured in 24 patients with type 2 diabetic nephropathy and 14 healthy adults as controls. Diabetic nephropathy was classified into three stages: stage 1 = normoalbuminuric, stage 2 = microalbuminuric, and stage 3 = macroalbuminuric. All of the patients showed normal ranges in renal function tests. Levels of urinary MCP‐1 in all patients with diabetic nephropathy were significantly higher than those in healthy adults (P < 0.05). The levels of urinary MCP‐1 in patients with diabetic nephropathy increased gradually according to the clinical stage of this disease. In contrast, the levels of urinary IL‐8 in patients with diabetic nephropathy increased in stages 2 and 3. There was a significant correlation between the levels of urinary IL‐8 and those of HbA1c. High glucose may stimulate MCP‐1 and/or IL‐8 production and their excretion into the urine independently of the phases or pathological lesions of this disease. It appears that IL‐8 increased in the early stage of diabetic nephropathy, and MCP‐1 increased in the advanced stage of this disease. It was concluded that measurement of urinary MCP‐1 and IL‐8 may be useful for evaluating the degree of renal injuries in patients with type 2 diabetic nephropathy. J. Clin. Lab. Anal. 16:1–4, 2002. © 2002 Wiley‐Liss, Inc.
Are Synbiotics added to the Standard Therapy to eradicate Helicobacter pylori in Children Beneficial? A Randomized Controlled Study

Aim: We aimed to evaluate the role of the addition of Bifidobacterium /actis-containing synbiotic to the triple therapy in the case of He/icobacter py/ori eradication, the dyspeptic symptoms, and reducing the side effects of antibiotics. Materials and methods: A total of 104 children aged between 5 and 17 years, who were histopathologically diagnosed with H. py/ori were enrolled in this study, of whom 100 were included in the analysis. Patients were randomly classified into two groups. In the first group, 50 patients were administered amoxicillin + clarithromycin + lansoprazole for 14 days and B. /actis-containing synbiotic. In the second group, 50 patients were treated with the standard triple therapy. All patients were given information after completion of therapy. Results: H. py/ori eradication was achieved in 88% in group I who received standard therapy with additional synbiotic and 72% in group II (p = 0.046). The number of patients in the second group who suffered from abdominal pain between the 3rd and 14th day of the treatment was higher (p < 0.05). The addition of probiotics to the triple therapy significantly reduced the frequency of diarrhea, but no significant difference was detected in the frequency of metallic taste (p = 0.04, p = 0.418 respectively). Conclusion: The addition of synbiotic to the triple therapy is effective for eradicating H. py/ori infection in children and is usually helpful to reduce or eliminate dyspeptic symptoms like abdominal pain, diarrhea, and vomiting. This study suggest that improved tolerance to the eradication treatment also reduces the treatment failure by adding probiotics and encourages the future study using probiotic supplementation in H. py/ori treatment. How to cite this article: Şirvan BN, Usta MK, Kizilkan NU, Urganci N. Are Synbiotics added to the Standard Therapy to eradicate He/icobacter Py/ori in Children Beneficial? A Randomized Controlled Study. Euroasian J Hepato-Gastroenterol 2017;7(1):17-22.
CIRCULATORY DYNAMICS IN THE BASAL STATE OBSERVED DURING CONVALESCENCE. CHANGES IN BODY WEIGHT, BLOOD VOLUME, AND VENOUS PRESSURE.

Complaints of the circulatory symptoms of palpitation, tachycardia out of proportion to exertion, postural vertigo, and dyspnea are frequent among convalescents as a group. The present study was undertaken to determine if the commonly employed methods of evaluating circulation could be used in the prognostic classification of convalescents, and if such methods would indicate underlying physiological disturbances susceptible to modification with an ultimate shortening of the recovery period.
Competing in the Graduate Labour Market: student perspectives on (not) participating in extra-curricular activities

In order to be able to compete in an increasingly competitive graduate labour market students need to develop their 'personal capital'. Participation in a range of relevant extra-curricular activities (ECAs) is a key element to the development of personal capital. This paper carried out in-depth interviews with undergraduates in the first and final years of their studies in order to understand the factors influencing their level of participation in ECAs. The research found that participation in ECAs was generally limited (with little change occurring during the three years of their degree), particularly in relation year-long work placements, volunteering and sporting and cultural activities. Students often engaged in part-time working, but this was for financial reasons, with few students regarding part-time working as a way of developing their employability. The students underlying values, especially their present-time orientation, and the desire to enjoy a particular student life-style, were acting as barriers to engaging in the type of ECAs that would help them to develop their personal capital. This paper suggests that we may be able to motivate students to participate in ECAs by encouraging them to be future-orientated, less risk averse and willing to adopt a more strategic (i.e. 'player') approach to developing their personal capital. The paper proposes that this can be achieved by encouraging students to write about their future possible selves and asking them to undertake research into the different career options open to them.
Mutation of the POU-Specific Domain of Pit-1 and Hypopituitarism Without Pituitary Hypoplasia

A point mutation in the POU-specific portion of the human gene that encodes the tissuespecific POU-domain transcription factor, Pit-1, results in hypopituitarism, with deficiencies of growth hormone, prolactin, and thyroid-stimulating hormone. In two unrelated Dutch families, a mutation in Pit-1 that altered an alanine in the first putative α helix of the POU-specific domain to proline was observed. This mutation generated a protein capable of binding to DNA response elments but unable to effectively activate its known target genes, growth hormone and prolactin. The phenotype of the affected individuals suggests that the mutant Pit-1 protein is competent to initiate other programs of gene activation required for normal proliferation of somatotrope, lactotrope, and thyrotrope cell types. Thus, a mutation in the POU-specific domain of Pit-1 has a selective effect on a subset of Pit-1 target genes.
The Organization of R&D in American Corporations: The Determinants and Consequences of Decentralization

We study the relationship between decentralization of R&D, innovation and firm performance using a novel dataset on the organizational structure of 1,290 American publicly-listed corporations, 2,615 of their affiliate firms, as well as characteristics of 594,903 patents that they hold. We explore the tension between centralization and decentralization of R&D, which trades off between responsiveness to immediate and local business needs and the type of research that can benefit the firm as a whole. To do this, we develop two novel measures of decentralization. First, using intra-firm patent assignments, we distinguish between patents that are assigned to the inventing unit rather than to corporate headquarters. Second, we exploit the variation between firms which posses a central corporate R&D labs and those that do not. We find that centralized R&D tends be more scientific, broader in scope, and have more technical impact, while being more likely in firms that operate within a narrower range of businesses, in complex technologies, or that are less reliant upon acquisitions. Additionally, we find that firms with a more decentralized structure, on average, invest less in R&D, generate fewer patents per R&D, and exhibit greater sales growth and higher market value. We discuss several theories that can explain these relationships, as well as potential avenues for future research.
Candida Endocarditis: Contemporary Cases from the International Collaboration of Infectious Endocarditis Merged Database (ICE-MD)

Candida infective endocarditis (IE) is increasingly common, yet most reports have been single-center reviews. We evaluated 16 patients with Candida IE nested within a cohort of 2,022 patients with IE. Prosthetic valve IE was more common in patients with Candida (50% vs 17%); mortality was 37% for patients with Candida.