Miracle-dz/UniFAR-FTUs huggingface dataset:
Disturbance observer–based dynamic surface control design for a hypersonic vehicle with input constraints and uncertainty

This article presents the flight control problem of a flexible air-breathing hypersonic vehicle under input constraint and aerodynamic uncertainty. First, a control-oriented model is derived and decomposed into velocity subsystem and altitude subsystem, in which compounded disturbances are included to consider aerodynamic uncertainty and the effect of the flexible modes. Second, nonlinear disturbance observer technique is employed to estimate the compounded disturbance, where the estimation error converges to a compact set if the observer design parameters are chosen appropriately. Then, based on disturbance observer, a robust controller and a dynamic surface controller are developed, respectively, for the velocity subsystem and the altitude subsystem. Third, novel robust first-order filters are designed to overcome the “explosion of terms” problem induced by backstepping method. Additional systems are constructed to tackle input constraints. By rigorously Lyapunov stability proof, the designed control strategy can assure that tracking error converges to an arbitrarily small neighborhood around zero. Finally, simulations are performed to show the effectiveness of the presented control strategy.
Posttraumatic Stress Disorder, Ego Defense Mechanisms, and Empathy among Urban Paramedics

Although numerous studies have indicated that paramedics experience high occupational stress, there has been a lack of research addressing the mental health implications of this elevated stress on these emergency workers. Related constructs such as the coping mechanisms and personality characteristics of paramedics have also been neglected. Groups of experienced paramedics (n = 120) and paramedic students (n = 105) were, therefore, assessed for Posttraumatic Stress Disorder, the extent and mode of ego defense utilization, and empathy. Analyses indicated that 20% of the experienced paramedics and 22% of the paramedic students appear to be suffering from trauma as measured by the MMPI-2 PK Scale. Denial and Repression scores were significantly high compared to normative samples for both groups, while Regression and Reaction Formation scores were significantly low. Both the paramedics and paramedic students had significantly low scores on Empathy. It is suggested that paramedics may be predisposed to these personality traits and that high denial and low empathy serve as functionally adaptive mechanisms in a chronically stressful work environment.
ANALISIS VECTOR AUTOREGRESSION (VAR) TERHADAP HUBUNGAN ANTARA BI RATE DAN INFLASI

Standard monetary policy is mirrored by the determination of the policy rate (BI Rate) which is expected to affect the money market interest rates and deposit rates and bank lending rates. These interest rate changes will ultimately affect output and inflation. The operational objective of monetary policy is reflected in the development of interest rates Overnight interbank money market (interbank O/N). Movements in interbank rates is expected to be followed by the development in interest rates on deposits, and in turn in bank lending rates. Taking also into account other factors in the economy. BI Rate announced by the Board of Governors of Bank Indonesia each meeting of the Board of Governors (RDG) monthly and implemented on monetary operations conducted by Bank Indonesia through the management of liquidity (liquidity management) in the money market to achieve the monetary policy operational target.
Facial Feminization: Systematic Review of the Literature

Background: Facial feminization surgery encompasses a broad range of craniomaxillofacial surgical procedures designed to change masculine facial features into feminine features. The surgical principles of facial feminization surgery can be applied to male-to-female transsexuals and anyone desiring feminization of the face. Although the prevalence of these procedures is difficult to quantify, because of the rising prevalence of transgenderism (approximately one in 14,000 men) along with improved insurance coverage for gender-confirming surgery, surgeons versed in techniques, outcomes, and challenges of facial feminization surgery are needed. This review is designed to critically appraise the current facial feminization surgery literature. Methods: A comprehensive literature search of the Medline, PubMed, and EMBASE databases was conducted for studies published through October of 2014 with multiple search terms related to facial feminization. Data on techniques, outcomes, complications, and patient satisfaction were collected. Results: Fifteen articles were selected and reviewed from the 24 identified, all of which were either retrospective or case series/reports. Articles covered a variety of facial feminization procedures. A total of 1121 patients underwent facial feminization surgery, with seven complications reported, although many articles did not explicitly comment on complications. Satisfaction was high, although most studies did not use validated or quantified approaches to address satisfaction. Conclusions: Facial feminization surgery appears to be safe and satisfactory for patients. Further studies are required to better compare different techniques to more robustly establish best practices. Prospective studies and patient-reported outcomes are needed to establish quality-of-life outcomes for patients. However, based on these studies, it appears that facial feminization surgery is highly efficacious and beneficial to patients.
Protective effect of rutin on impairment of cognitive functions of due to antiepileptic drugs on zebrafish model

Aim: The severity of adverse reactions due to antiepileptics is observed during initiation and early treatment in which impairment of cognitive effects are common. Since long time, herbal medicine is a natural remedy to treat neural symptoms. Phytochemicals have been proven to be potent neuro-protective agents. Rutin, a bioflavonoid is established to be nootropic in many studies. In this study, we aimed to determine the protective effect of rutin in zebrafish against the side effects produced by AEDs. Materials and Methods: Seizures were induced in zebrafish by phenylenetetrazole. Rutin pretreatment (50 mg/kg, single injection, i.p.) was done before commencement of the study. Behavioral studies were performed as: latency to move high in the tank, locomotion effects, color effect, shoal cohesion, light/dark test on Zebrafish. Results: Treatment with rutin reverted the locomotor behavior to normal. Treatment with AEDs caused fishes to move in all regions while, in case of treatment with rutin, the response reverted to normal. Treatment with AEDs altered swimming behavior of zebrafish, however, rutin showed a positive effect over this behavior. Treatment with AEDs resulted in restricted movement of zebrafish to the dark zone. Treatment with rutin caused increased latency of zebrafish to move in the light compartment. Similarly, time spent in the light compartment by zebrafish treated with rutin was significantly (P < 0.01) higher as compared to zebrafish treated with AEDs. Conclusion: The results suggest a protective role of rutin on cognition impaired by AEDs.
Perceived Need for Mental Health Treatment in a Nationally Representative Canadian Sample

Objective: The optimal method of determining how many people in the general population need help for emotional problems remains unclear. This study aimed to examine the prevalence and correlates of self-perceived need for mental health services (that is, help seeking and perceived need) in a large, population-based sample. Methods: Data came from the Canadian Community Health Survey 1.2 (n = 36 816, respondent age 15 years and over, and response rate 77%). Respondents were asked whether they had sought help in the past year from any professional for emotional problems and whether they felt they needed help for emotional symptoms but had not sought treatment. The Composite International Diagnostic Interview (CIDI) was used to make DSM-IV mental disorder diagnoses. Results: The past-year prevalences of help seeking and perceived need were 8.7% and 2.9%, respectively. After adjusting for the presence of DSM-IV disorders assessed in the survey, sociodemographic factors, illness severity, social supports, and the presence of physical health conditions were associated with help seeking and perceived need. Independent of DSM diagnoses, sociodemographics, and social supports, perceived need and help seeking were associated with increased levels of distress, disability, and suicidal ideation and attempts. Conclusions: This study illustrates that, in addition to the presence of a DSM diagnosis, the respondent's self-perceived need for mental health treatment is important in the assessment of need for mental health services in the community.
CD4+ T Lymphocytes Are Critical Mediators of Tumor Immunity to Simian Virus 40 Large Tumor Antigen Induced by Vaccination with Plasmid DNA

ABSTRACT A mechanistic analysis of tumor immunity directed toward the viral oncoprotein simian virus 40 (SV40) large tumor antigen (Tag) has previously been described by our laboratory for scenarios of recombinant Tag immunization in BALB/c mice. In the present study, we performed a preliminary characterization of the immune components necessary for systemic tumor immunity induced upon immunization with plasmid DNA encoding SV40 Tag as a transgene (pCMV-Tag). Antibody responses to SV40 Tag were observed via indirect enzyme-linked immunosorbent assay following three intramuscular (i.m.) injections of pCMV-Tag and were typified by a mixed Th1/Th2 response. Complete tumor immunity within a murine model of pulmonary metastasis was achieved upon two i.m. injections of pCMV-Tag, as assessed by examination of tumor foci in mouse lungs, without a detectable antibody response to SV40 Tag. Induction-phase and effector-phase depletions of T cell subsets were performed in vivo via administration of depleting rat monoclonal antibodies, and these experiments demonstrated that CD4+ T lymphocytes are required in both phases of the adaptive immune response. Conversely, depletion of CD8+ T lymphocytes did not impair tumor immunity in either immune phase and resulted in the premature production of antibodies to SV40 Tag. Our findings are unique in that a dominant role could be ascribed to CD4+ T lymphocytes within a model of DNA vaccine-induced tumor immunity to Tag-expressing tumor cells. Additionally, our findings provide insight into the general mechanisms of vaccine-induced tumor immunity directed toward tumors bearing distinct tumor-associated antigens.
Non-surgical endodontic treatment of premolars with three root canals: a case reports

To perform successful endodontic therapy, it is important to know the anatomy and morphology of the root canal system. Peculiarities with possible anatomic variations may lead to failure due to insufficient instrumentation and inadequate three-dimensional obturation of the root canal system. [1,2] Accurate radiographic examination using different horizontal angles is crucial for the endodontist to recognize the roots and root canals. Additionally, the observation of the pulp chamber anatomy during coronal access is an essential procedure for the correct clinical location of root canal orifices. [3] The high frequency of endodontic flare-ups and failures is associated with variation in root canal morphology. The factors that can contribute to observed differences in the anatomic study include ethnicity, age, gender and study design (in vitro versus in vivo). [4] The presence of three root canals in maxillary premolars of the Turkish population is a very rare occurrence as reported by several studies. [5–7] The presence of three root canals in mandibular premolars of the Turkish population is also a very rare occurrence as reported by Sert et al. and Ok et al. studies. [7,8] The use of magnification and fiber optic illumination, offers a tremendous advantage in locating and treating “extra” canals. Also the dental operating microscope (DOM), has been found to be particularly helpful. The efficient use of the DOM requires advanced training. Many endodontic procedures are performed at 10× to 15× magnification, and some require a magnification as high as 30×. The skillful use of a DOM entails its use for the entire procedure from start to finish. Working in such a way requires the endodontist to possess a high level of ergonomic and visual skills. [9] This paper reports the endodontic treatment of three cases of three-canalled maxillary premolars in different patients and the endodontic treatment of one case of threecanalled mandibular premolars in a different patient. An accurate diagnosis of the morphology of the root canal system is a prerequisite for successful root canal treatment. Some reports reveal a very rare occurrence of all types of premolar teeth in the Turkish population. Diagnostic tools such as preoperative radiography and examination of the pulp chamber floor facilitate the location of root canal orifices. The use of magnification tools, radiography exposed at two different horizontal angles, and their careful explication are important for successful endodontic therapy. This case report presents the successful endodontic treatment of three maxillary premolar teeth with three root canals and one mandibular premolar tooth with three root canals.
Education Language and Youth Entrepreneurship in Chad

ABSTRACT This study aims to assess the effect of education language (Arabic or French) on the probability of being self-employed in Chad. Mainly, we make use of a recursive bivariate Probit model and matching techniques to assess the effect, as well as to remedy to the endogeneity problem. Overall the analysis suggests that youths with Arabic-language education are more likely to be self-employed, however, most of them specialise in modest informal micro-enterprises. These results can help to shed light on the education language implications, and then, can help policymakers to design appropriate policies to foster youth entrepreneurship in Chad.
The pathophysiology of chronic graft-versus-host disease

Chronic graft-versus-host disease (GVHD) still remains the most significant complication after allogeneic hematopoietic stem cell transplantation. The disease usually appears after day 100 and is characterized by signs and symptoms similar to autoimmune diseases.The pathophysiology of chronic GVHD is poorly understood because of the lack of highly satisfactory animal models and basic studies in patients. It has not been clearly determined whether the disease is a distinct entity or a continuation of acute GVHD. In experimental and clinical studies of chronic GVHD, thymic atrophy, lymphocyte depletion, and autoantibody formation have been described. Conditioning regimens and acute GVHD may disrupt thymic function and dysregulate the negative selection process of potentially autoreactive T-lymphocytes. Disruption of thymic apoptosis and failure to eliminate the majority of self-reactive lymphocytes may lead to impairment of lymphocyte homeostasis and self tolerance. Expansion and effector functions of autoreactive T-cells will then promote autoreactive B-cell activation and production of autoantibodies with target-organ damage. Chronic GVHD requires continuous CD4+ T-cell help for B-cells and is known as T-helper 2 (Th2) disease. Murine models have demonstrated the roles of interleukin (IL)-12 and IL-18 in chronic GVHD. IL-12 may cause an increase in donor CD8+ cytotoxic T-cells leading to conversion of chronic GVHD to an acute form. In contrast, IL-18 prevents chronic GVHD by decreasing numbers of CD4+ (Th2) cells and host-reactive B-cell activation and reducing alloantigen-specific immune response. Mouse and human cellular genomics coupled with advances in cell biology in donorrecipient tolerance will improve our understanding of transplantation immunology and may offer new approaches to the challenge of ameliorating chronic GVHD.
Type of closure prevents microbial contamination of cosmetics during consumer use

The dispensing closure used for containers plays an important role in protecting cosmetics from in-use microbial contamination. This hypothesis was tested by aseptically packing unpreserved shampoo and skin lotion into containers with three different closure types which provided various degrees of protection against consumer and environmental microbial insults. Shampoo was packed in containers with slit-cap (n = 25), flip-cap (n = 25), or screw-cap (n = 28) closures. Skin lotion was packed in containers with pump-top (n = 21), flip-cap (n = 18), or screw-cap (n = 21) closures. The products were then used by volunteers under actual in-use conditions for 3 (shampoo) or 2 (skin lotion) weeks. After use, the products were evaluated for microbial contamination by using standard methods for enumeration and identification. The standard screw-cap closure provided only minimal protection against microbial contamination of both the shampoo (29% contamination incidence) and the skin lotion (71%). The slit-cap closure on the shampoo container and the flip-cap closure on the skin lotion container provided slightly enhanced degrees of protection (21 and 39% contamination incidence, respectively). The greatest amount of protection (i.e., lowest contamination incidence) was provided by the flip-cap closure for the shampoo container (0%) and the pump-top closure for the skin lotion container (10%). As a result, closure type plays an important role in protecting poorly preserved products from in-use microbial contamination.
Effects of managerial response on consumer eWOM and hotel performance

Purpose This study aims to measures the effects of managerial response on consumer electronic word-of-mouth (eWOM) and hotel performance. Design/methodology/approach A sample of 56,284 consumer reviews and 10,793 managerial responses for 1,045 hotels was retrieved from TripAdvisor, along with 30,232 performance records matched to these hotels on a quarterly basis. Findings This study finds that managerial response leads to an average increase of 0.235 stars in the TripAdvisor ratings of the sampled hotels, as well as a 17.3 per cent increase in the volume of subsequent consumer eWOM. Moreover, managerial response moderates the influence of ratings and volume of consumer eWOM on hotel performance. Practical implications This study offers a practical model that enables hotel managers to orchestrate social media marketing approaches and efforts toward an optimal social media strategy. Originality/value This study differs from extant literature that has extensively focused on consumer reviews by providing a new perspective of management intervention in the social media context. By examining the interplay of managerial response and consumer eWOM at the individual hotel level, this study provides empirical evidence of managerial response affecting hotel performance through the increased ratings and volume of consumer eWOM. This study also offers insights into the practical importance of crafting intervention opportunities to cultivate the continued engagement of consumers on social media and increased hotel performance.
Immunohistochemical Staining of Papillary Breast Lesions

The separation of ductal papilloma from intraductal papillary carcinoma of the breast on hematoxylin and eosin stained sections often presents diagnostic difficulty. Immunohistochemical staining is often employed in diagnosis, historically with smooth muscle actin (SMA). In this study, the staining characteristics of a panel of myoepithelial markers (calponin, p63, P-cadherin), were compared with SMA, and the epithelial expression of CD44s was assessed in 99 papillary lesions. SMA, calponin, and p63 demonstrated myoepithelial cells in 61%, 63%, and 65% of papillary lesions, respectively. However, specificity was quite variable. Calponin-stained stromal myofibroblasts (35% of cases), vessel pericytes (92%), and endothelial cells (69%), though each to a lesser degree than SMA. Calponin also showed cross reactivity with epithelium in 18% of cases. p63 was almost completely restricted to myoepithelial cell nuclei, and did not stain vascular smooth muscle or myofibroblasts. However, p63 stained the epithelial component in one papillary carcinoma, a basal layer of cells in 1 biphasic invasive carcinoma, and the cytoplasm in 1 case. P-cadherin stained both epithelial and myoepithelial cells. The epithelial expression of CD44s and did not distinguish papillomas from papillary carcinomas. Thus, P-cadherin and CD44s are not useful in the characterization of papillary lesions. Given increased specificity as compared with SMA, the combination of p63 and calponin is recommended for analysis of breast papillary lesions.
Plasticity and Virus Specificity of the Airway Epithelial Cell Immune Response during Respiratory Virus Infection

ABSTRACT Airway epithelial cells (AECs) provide the first line of defense in the respiratory tract and are the main target of respiratory viruses. Here, using oligonucleotide and protein arrays, we analyze the infection of primary polarized human AEC cultures with influenza virus and respiratory syncytial virus (RSV), and we show that the immune response of AECs is quantitatively and qualitatively virus specific. Differentially expressed genes (DEGs) specifically induced by influenza virus and not by RSV included those encoding interferon B1 (IFN-B1), type III interferons (interleukin 28A [IL-28A], IL-28B, and IL-29), interleukins (IL-6, IL-1A, IL-1B, IL-23A, IL-17C, and IL-32), and chemokines (CCL2, CCL8, and CXCL5). Lack of type I interferon or STAT1 signaling decreased the expression and secretion of cytokines and chemokines by the airway epithelium. We also observed strong basolateral polarization of the secretion of cytokines and chemokines by human and murine AECs during infection. Importantly, the antiviral response of human AECs to influenza virus or to RSV correlated with the infection signature obtained from peripheral blood mononuclear cells (PBMCs) isolated from patients with acute influenza or RSV bronchiolitis, respectively. IFI27 (also known as ISG12) was identified as a biomarker of respiratory virus infection in both AECs and PBMCs. In addition, the extent of the transcriptional perturbation in PBMCs correlated with the clinical disease severity. Our results demonstrate that the human airway epithelium mounts virus-specific immune responses that are likely to determine the subsequent systemic immune responses and suggest that the absence of epithelial immune mediators after RSV infection may contribute to explaining the inadequacy of systemic immunity to the virus.
Staphylococcus aureus 3-Hydroxy-3-methylglutaryl-CoA Synthase

3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, a member of the family of acyl-condensing enzymes, catalyzes the first committed step in the mevalonate pathway and is a potential target for novel antibiotics and cholesterol-lowering agents. The Staphylococcus aureus mvaS gene product (43.2 kDa) was overexpressed in Escherichia coli, purified to homogeneity, and shown biochemically to be an HMG-CoA synthase. The crystal structure of the full-length enzyme was determined at 2.0-Å resolution, representing the first structure of an HMG-CoA synthase from any organism. HMG-CoA synthase forms a homodimer. The monomer, however, contains an important core structure of two similar α/β motifs, a fold that is completely conserved among acyl-condensing enzymes. This common fold provides a scaffold for a catalytic triad made up of Cys, His, and Asn required by these enzymes. In addition, a crystal structure of HMG-CoA synthase with acetoacetyl-CoA was determined at 2.5-Å resolution. Together, these structures provide the structural basis for an understanding of the mechanism of HMG-CoA synthase.