Miracle-dz/UniFAR-FTUs huggingface dataset:
ASSOCIATION OF THE G PROTEIN β3 SUBUNIT T ALLELE WITH INSULIN RESISTANCE IN ESSENTIAL HYPERTENSION

A polymorphism (C825T) in the gene encoding the G protein β3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations. The aim of the study was to analyse the relationship between this polymorphism and insulin sensitivity, an hypothesised unifying factor for hypertension and obesity. One hundred thirty unrelated patients with essential hypertension, 70 female and 60 male, aged 58±1 years with systolic blood pressure of 173±2 mm Hg and diastolic blood pressure of 105±1 mm Hg, were genotyped for the GNB3 polymorphism by PCR and restriction digestion with BseDI, and classified in two groups according to the genotypes CC and CT+TT. Body mass index (BMI) was significantly higher in patients with the T allele as compared with patients without the T allele (29.3±0.4 vs. 26.7±0.6 kg/m2, p<0.001). On the contrary, there were no differences in the level of systolic or diastolic blood pressure among the genotypes. Insulin sensitivity was measured in a subgroup of 35 patients by means of an euglycemic hyperinsulinemic clamp test. In this subgroup, patients with the T allele displayed lower insulin sensitivity index (1.6±0.3 vs. 2.7±0.3 mg/kg/min, p=0.022), higher fasting serum insulin (121±16 vs. 77±11 pmol/L, p=0.032), higher serum glucose 120 min after 75 g load (9.8±1.2 vs. 7.0±0.5 mmol/L, p=0.038), and higher glycosilated haemoglobin (5.7±0.4 vs. 4.7±0.2%; p=0.042) as compared with patients without the T allele. A regression analysis showed that the association between the T allele and insulin sensitivity was independent of BMI (β coefficient −0.386, p=0.022). These results suggest a relationship between the 825T allele of GNB3 and insulin resistance in the essential hypertensive patients studied, which seems to be independent of BMI.
The relationship of anteroposterior, transepicondylar and posterior condylar axis of the femur: a Thai cadaveric study using digital measurement.

OBJECTIVE To study the normal relationship of the anteroposterior (AP), transepicondylar (TE) and posterior condylar (PC) axis of cadaveric femoral bones using digital technology and special computer program. MATERIAL AND METHOD Digital image of distal femur of 100 cadaveric bones of both sides and both sexes were taken using a special stand and clamp to ensure the same view and same distance from bone to camera. All still images were transferred into a specially developed computer program, then reference points were located by two observers, and were done twice at one week interval. The program reported the angle between AP-TE, AP-PC and TE-PC axes automatically. The data was then analyzed. RESULTS The age of donor cadaveric bones ranged from 22 to 58 years (average 45.61 +/- 7.73). The AP-TE, AP-PC and TE-PC angles were 92.43 +/- 2.07, 86.65 +/- 1.85 and 5.79 +/- 1.26, respectively. The correlation coefficients of intra-observer reliability in observer 1 were 0.89, 0.87 and 0.91; in observer 2 were 0.92, 0.90 and 0.87. The correlation coefficients of inter-observer reliability were 0.81, 0.82 and 0.80. Limit agreement tests of AP-TE, AP-PC and TE-PC were 90.59%, 92. 57% and 96.03%, in that order. CONCLUSION Using digital technology, the normal relationship of AP, TE and PC axes of femur from cadaveric bone could be more accurately studied comparing with the previous studies performing measurement on plain film, CT scan or MRI using goniometer.
Rufibacter glacialis sp. nov., a psychrotolerant bacterium isolated from glacier soil.

A Gram-stain-negative, rod-shaped, red-pigmented bacterium (MDT1-10-3T) was isolated from Midui glacier in Tibet, China. Cells were aerobic and psychrotolerant (growth occurred at 4-25 °C). Phylogenetic analysis based on 16S rRNA gene sequences indicated that it was a member of the genus Rufibacter, with Rufibacter immobilis MCC P1T (96.7 % similarity) as its closest phylogenetic relative. MK-7 was the predominant respiratory menaquinone. The major cellular fatty acids were summed feature 4 (iso-C17 : 1 I and/or anteiso-C17 : 1 B), summed feature 3 (C16 : 1ω6c and/or C16 : 1ω7c), C17 : 1ω6c, iso-C16 : 0, iso-C15 : 0 and C16 : 1ω5c. The predominant polar lipids were phosphatidylethanolamine, two unidentified aminophospholipids, one glycolipid and four unidentified lipids. The G+C content of the genomic DNA was 49 mol%. On the basis of the phenotypic characteristics and phylogenetic analysis, strain MDT1-10-3T represents a novel species of the genus Rufibacter, for which the name Rufibacter glacialis sp. nov. is proposed. The type strain is MDT1-10-3T ( = CGMCC 1.9789T = NBRC 109705T).
Gender and Household Economic Strategies in Rural Appalachia

In recent decades, many Appalachian households have experienced declining incomes due to the loss of traditional male jobs in the mining and manufacturing sectors. One response to this decline has been an increase in female employment in formal sector activities. Another response is homework, or the home-based production of goods and services for sale in the formal and informal sectors. In rural Appalachia, where formal jobs are often unavailable or inadequate to support a household, many women are engaging in homework as an economic strategy. Consequently, economic restructuring cannot be fully understood without analyzing household strategies and gender relations. This paper examines the intersection of gender, households, and economic restructuring as it relates to women's homework and employment shifts in rural Appalachia. Research for this paper entailed qualitative interviews with 50 West Virginia women who are engaged in the home-based production of goods and services. The study analyzes the variet.
A Collection of Essays on Electric Grid Operations: Optimizing Energy Storage and Enhancing the Effect of Social Comparisons.

A Collection of Essays on Electric Grid Operations: Optimizing Energy Storage and Enhancing the Effect of Social Comparisons by Santhosh Suresh Co-Chairs: Assistant Professor Owen Wu and Professor Roman Kapuscinski Every year, a significant portion of the energy the U.S. electric grid consumes is wasted through transmission, heat losses, and inefficient technology, translating into significant costs to individual consumers and businesses. Improving the efficiency of the electric grid is one of the easiest and most cost effective ways to combat climate change, clean the air we breathe, improve the competitiveness of our businesses and reduce energy costs for consumers. Governments across the world are focusing on ways to achieve it. This dissertation explores various ways of improving the grid operations related to energy storage. Storage allows for smoothing production and hence avoiding the costly peaking plants. However, scalable energy storage technology, such as Lead Acid Batteries or Pumped Storage units are expensive and have significant conversion losses in both the storing and withdrawing processes. The first two essays in the dissertation consider energy storage. The first essay considers the problem of locating storage facilities in an electric grid. Due to transmission losses, congestion and reliability issues, the location of storage technology on the grid affects its economic value. We consider a trade-off between locating storage closer to the generation unit, increasing flexibility of the storage unit, or closer to the demand hub, reducing transmission losses and study how changes in system parameters will affect this trade-off. We derive a structure for the optimal operating policy and conclude that
Role of Trimetazidine in Coronary Artery Bypass Graft Surgery

Trimetazidine is a drug that has been used to reduce the damage of reperfusion injury, which is a mechanism of oxidative aggression that occurs in coronary syndromes, angioplasty procedures, as well as in cardiovascular surgeries. Seeking to improve myocardial protection during procedures that involve reperfusion, attention was recently turned to research on cytoprotective drugs which act on segments of cellular metabolism, used in isolation or combined to reduce or prevent damage to the cardiac cell. The aim of this review is to objectively evaluate the effects of the drug trimetazidine (TMZ) on ischemia-reperfusion injury in coronary artery bypass graft surgery by reviewing all known studies from recent years.
Dissolving efficacy of eucalyptus and orange oil, xylol and chloroform solvents on different root canal sealers.

AIM To evaluate the solubility of five root canal sealers in orange oil, eucalyptol, xylol and chloroform solvents. METHODOLOGY The solubility of RoekoSeal, Sealer 26, Epiphany, Endomethasone and EZ-Fill sealers was assessed in orange oil, eucalyptol, xylol, chloroform and distilled water. Seventy-five samples of root canal sealers were prepared and then divided into five groups for immersion in solvent for 2, 5 or 10 min. The means of loss weight were determined for each material in each solvent at all immersion periods, and the values were compared by factorial analysis of variance (anova) and SNK multiple comparisons. RESULTS In the orange and eucalyptus oil groups, there was no significant difference among RoekoSeal, Sealer26, Epiphany and EZ-Fill at the three immersion periods (P > 0.05). With xylol, no significant differences were found at 5 and 10 min (P > 0.05) for each root sealer. Orange and eucalyptus oil solvents were as effective as chloroform at 2 min in dissolving all the root sealers. CONCLUSIONS Xylol was the most effective solvent followed by the chloroform and the essential oils (eucalyptol and orange oil). Orange oil behaved in a similar way to eucalyptus oil.
Procyclicality and Path Dependence of Sovereign Credit Ratings: The Example of Europe

This paper investigates empirically the behavior of Credit Rating Agencies (CRAs) when assessing sovereign solvency for European countries. Using probit regressions, I find that even after controlling for macroeconomic factors, CRAs take the business cycle into account. Also, there is a clear case of path dependence in sovereign ratings. Additionally, it turns out that there seems to be a discrepancy between upgrades and downgrades. These results are robust to a number of different specifications.
Effect of storage temperature on the decay of catechins and procyanidins in dark chocolate

Pavlović A.N. , Mrmošanin J.M. , Krstić J.N. , Mitić S.S. , Tošić S.B. , Mitić M.N. , Arsić B.B. , Micić R.J. (2017): Effect of storage temperature on the decay of catechins and procyanidins in dark chocolate. Czech J. Food Sci., 35: 360–366. The storage stability of catechins, procyanidins, and total flavonoids in dark chocolate was investigated. The obtained results showed that the degradation of flavonoids followed first-order reaction kinetics. Temperaturedependent degradation was modelled on the Arrhenius equation. The activation energy for the degradation of dark chocolate flavonoids during storage was 61.2 kJ/mol. During storage, flavonoids degraded more rapidly at 35°C (k = 7.8 × 10–3/day) than at 22°C (k = 5.4 × 10–3/day) and 4°C (k = 2.2 × 10–3/day).
Narratives of 'single homeless people' : reformulating and reinterpreting the homelessness experience

This PhD study focuses on understanding formerly homeless people’s attitudes to self, their home and their status in the housing system. The study was based on the analysis of twenty-eight narrative interviews with people who had experienced homelessness and who were, at the time of the interview, living in supported housing in a city in the South East of England. The decade 2000-2010, which provides the policy context for the research, was seen as a period of positive developments in homelessness research. In the current study and by using a combined narrative and thematic research approach, I place the single homeless people’s conceptualisations of identity into the Third Space (Shilling 1999, Burkitt 2008) presentation of flexible individualities, but which, despite the challenges and pressures experienced, maintain a strong sense of the core of the self that makes them unique. My approach to the homeless people’s identity formation accepts the possibility of a decentralisation of identities in contemporary societies; however, I maintain that there are parts of own identity which persist in individuals’ definitions of self and ultimately help ground the homeless individual. I acquiesce that identities can go through changes, imposed by personal circumstances and social context, and that these changes can lead to variations in the elements which retain value for the individual. However, despite all these changes, the homeless interviewees continued to refer to their self as easily recognised – retaining the same main qualities which belonged to the self before the homelessness experience. It was this strength of self that the interviewees ultimately wanted to transmit to the interviewer and it is this strength of self which places their conceptualisations of identity in the ‘Third Space’ approach. The study was placed at a crossroads for homelessness policies which had passed through a series of changes through two different governments: New Labour and the Coalition Government. As well as highlighting areas that required improvement, the study showed that a holistic perspective towards the homeless person, taking into account their experiences before, after and during the homelessness event and acknowledging the value of training and unpaid employment, could lead to policy and practice which is closer to individuals’ perceived identities and routes out of homelessness.
Adolescents’ Mobile Phone Use While Crossing the Road

Phones and other portable technology can be a distraction for pedestrians, affecting their ability to cross a road safely. This study focused on adolescents and investigated whether using a phone distracts attention while crossing the road. A field observation outside a secondary school in the north of England was carried out over a four-week period in 2018 with permission from the school. Observations included recording what accessories the pedestrian was carrying (phone, headphones or another electronic device) and their associated action (whether they were holding the device, speaking into a phone, looking at it, holding it to their ear or interacting with it manually). We observed whether the pedestrian looked (or failed to look) left and right before crossing the road, whether they crossed when the pedestrian light was on green or red, and whether they crossed within the cross-walk. We found that 31.37% of road crossings were made by adolescents with a phone or other device. They looked left and right before crossing less frequently when they had an electronic device with them, when looking at the screen and when texting or swiping. In conclusion, the safety of adolescent pedestrians is affected by mobile phones and music players.
Prediction of in vivo drug clearance from in vitro data. II: Potential inter-ethnic differences

Potential differences in drug clearance between Japanese and Caucasians were investigated by integrating data on demography, liver size, the abundance of the major cytochromes P450 and in vitro metabolic parameters. Eleven drugs (alprazolam, caffeine, chlorzoxazone, cyclosporine, midazolam, omeprazole, sildenafil, tolbutamide, triazolam, S-warfarin and zolpidem) fulfilled the entry criteria of the study (i.e. the necessary in vitro metabolism data were available and clearance values had been reported both in Caucasians and Japanese). Values of relevant biological variables were obtained from the literature, and clearance predictions were made using the Simcyp® Population-Based ADME Simulator. The ratios of observed oral clearance (CLp.o.) values in Caucasians compared with Japanese ranged from 0.6 to 2.8 (integrating data from 82 sources). The CLp.o. values for alprazolam, caffeine and zolpidem were not statistically different between Caucasian and Japanese (p > 0.05), whereas those for chorzoxazone, cyclosporine, omeprazole, tolbutamide and triazolam were higher in Caucasians (p < 0.05), and those for midazolam, sildenafil and S-warfarin were higher in Japanese (p < 0.05). CLp.o. values, predicted from in vitro data, were within 3-fold of observed in vivo values for seven of the 11 drugs in Japanese. Values for the predicted ratios ranged from 1.6 to 4.9. The predicted ratios were not significantly different from observed ratios for cyclosporine, omeprazole, tolbutamide and triazolam. Only partial success in predicting ethnic differences in clearance indicates the need for larger and more reliable databases on relevant variables. With such information, in silico predictions might be used with more confidence to decrease the need for repeating pharmacokinetic studies in different ethnic groups.
Cancer Mortality of Workers Exposed to Styrene in the U.S. Reinforced Plastics and Composite Industry

Background: Epidemiologic studies have reported increased risk of lymphohematopoietic cancers, lung cancer, and pancreatic cancer after exposure to styrene, although findings across studies are not consistent. Methods: We update a large study of reinforced plastic industry workers with relatively high exposures to styrene, examining cancer risks associated with exposure levels. The study includes 15,826 workers who were exposed between 1948 and 1977 with vital-status follow-up from 1948 to 2008. We examine mortality rates associated with cumulative exposure, duration of exposure, peak exposures, average exposure, and time since first exposure to styrene. Exposure estimates were truncated starting in 1977, the period with the lowest exposures, leaving 27% of the study group with incomplete work histories. Results: The standardized mortality ratios were 0.84 (95% confidence interval = 0.69–1.02) for all lymphatic and hematopoietic cancers combined, 0.72 (0.50–1.00) for non-Hodgkin lymphoma, and 0.84 (0.60–1.14) for leukemia. There was no trend with either cumulative exposure to styrene or number of peaks. Pancreatic cancer deaths were at expected levels (0.96 [0.73–1.22]). There were more lung cancer deaths than expected (1.34 [1.23–1.46]), although with a marked inverse trend with cumulative exposure. Conclusion: We found no coherent evidence that styrene exposure increases risk from cancers of the lymphatic and hematopoietic tissue, pancreas, or lung.
Neural integration of iconic and unrelated coverbal gestures: A functional MRI study

Gestures are an important part of interpersonal communication, for example by illustrating physical properties of speech contents (e.g., “the ball is round”). The meaning of these so‐called iconic gestures is strongly intertwined with speech. We investigated the neural correlates of the semantic integration for verbal and gestural information. Participants watched short videos of five speech and gesture conditions performed by an actor, including variation of language (familiar German vs. unfamiliar Russian), variation of gesture (iconic vs. unrelated), as well as isolated familiar language, while brain activation was measured using functional magnetic resonance imaging. For familiar speech with either of both gesture types contrasted to Russian speech‐gesture pairs, activation increases were observed at the left temporo‐occipital junction. Apart from this shared location, speech with iconic gestures exclusively engaged left occipital areas, whereas speech with unrelated gestures activated bilateral parietal and posterior temporal regions. Our results demonstrate that the processing of speech with speech‐related versus speech‐unrelated gestures occurs in two distinct but partly overlapping networks. The distinct processing streams (visual versus linguistic/spatial) are interpreted in terms of “auxiliary systems” allowing the integration of speech and gesture in the left temporo‐occipital region. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

Combination therapy of bortezomib with other chemotherapeutics is an emerging treatment strategy. Since both curcumin and bortezomib inhibit NF-κB, we tested the effects of their combination on leukemia cells. To improve potency, a novel Mannich-type curcumin derivative, C-150, was synthesized. Curcumin and its analogue showed potent antiproliferative and apoptotic effects on the human leukemia cell line, HL60, with different potency but similar additive properties with bortezomib. Additive antiproliferative effects were correlated well with LPS-induced NF-κB inhibition results. Gene expression data on cell cycle and apoptosis related genes, obtained by high-throughput QPCR, showed that curcumin and its analogue act through similar signaling pathways. In correlation with in vitro results similar additive effect could be obsereved in SCID mice inoculated systemically with HL60 cells. C-150 in a liposomal formulation given intravenously in combination with bortezomib was more efficient than either of the drugs alone. As our novel curcumin analogue exerted anticancer effects in leukemic cells at submicromolar concentration in vitro and at 3 mg/kg dose in vivo, which was potentiated by bortezomib, it holds a great promise as a future therapeutic agent in the treatment of leukemia alone or in combination.
Kandungan Prinsip Konservatisme dalam Standar Akuntansi Keuangan Berbasis IFRS (International Financial Reporting Standard)

Kandungan Prinsip Konservatisme Dalam Standar Akuntansi Keuangan Berbasis IFRS (International Financial Reporting Standard) Ahmad Juanda Staf Pengajar Jurusan Akutansi, Fakultas Ekonomi dan Bisnis Universitas Muhammadiyah Malang juanda@umm.ac. id ABSTRACT This study aims to reveal the content of the principle of conservatism contained in financial accounting standards (GAAP) results of the convergence of International Financial Reporting Standards (IFRS). The use of the principle of conservatism still remains controversial, but several studies actually provide justification of the importance of the application of these principles, especially in the face of environmental uncertainty. Justification of the importance of the principle of conservatism that was not in line with IFRS. Some results of the study stated that IFRS does not recognize the principle of conservatism. By his deep permasalahn in this research is to explain why the IFRS less acknowledge the prinspi conservatism? The expected outcome of this research is a taxonomic arrangement conservatism principle and the justification of normative theories to standardize the accounting treatment. The analytical method used is content analysis, which analyzes the content of the information against a set of regulatory accounting standards. The aspects assessed were associated with bagimana accounting standards for the accounting of companies in Indonesia, especially that go public. The results showed that. Accounting conservatism still play a role in the implementation of IFRS. IASB Standards (IFRS) do not refer explicitly to the application of the principle of conservatism, because it is not in accordance with the IFRS conceptual framework. However, conservatism does not go away just because it does not "stressed" in the standard. With the uncertainty of the application of conservatism will remain in the financial statements. Keywords: perinsip Conservatism, IFRS, Financial Accounting Standards