Miracle-dz/UniFAR-FTUs huggingface dataset:
Motivational Interviewing to Prevent Childhood Obesity: A Cluster RCT

OBJECTIVE: The objective was to evaluate a manualized theory-driven primary preventive intervention aimed at early childhood obesity. The intervention was embedded in Swedish child health services, starting when eligible children were 9 to 10 months of age and continuing until the children reached age 4. METHODS: Child health care centers in 8 Swedish counties were randomized into intervention and control units and included 1355 families with 1369 infants. Over ∼39 months, families in the intervention group participated in 1 group session and 8 individual sessions with a nurse trained in motivational interviewing, focusing on healthy food habits and physical activity. Families in the control group received care as usual. Primary outcomes were children’s BMI, overweight prevalence, and waist circumference at age 4. Secondary outcomes were children’s and mothers’ food and physical activity habits and mothers’ anthropometrics. Effects were assessed in linear and log-binominal regression models using generalized estimating equations. RESULTS: There were no statistically significant differences in children’s BMI (β = –0.11, 95% confidence interval [CI]: –0.31 to 0.08), waist circumference (β = –0.48, 95% CI: –0.99 to 0.04), and prevalence of overweight (relative risk = 0.95, 95% CI: 0.69 to 1.32). No significant intervention effects were observed in mothers’ anthropometric data or regarding mothers’ and children’s physical activity habits. There was a small intervention effect in terms of healthier food habits among children and mothers. CONCLUSIONS: There were no significant group differences in children’s and mothers’ anthropometric data and physical activity habits. There was, however, some evidence suggesting healthier food habits, but this should be interpreted with caution.
Reserve Bank of St . Louis Working Paper Series Are Children “ Normal ” ?

In his classic work on the economics of fertility, Becker (1960) suggests that children are likely “normal. ” We examine this contention. Our first step is documenting an empirical regularity about the cross section of non-Hispanic white married couples in the U.S.: When we restrict comparisons to similarly-educated women living in similarly-expensive locations, completed fertility is positively correlated with the husband’s income. The empirical evidence is consistent with a simple model of household location and fertility choice, with children being “normal. ” But this evidence does not settle issues of causality. In an effort to sort out causal effects, we undertake a rather specialized empirical exercise to analyze the localized impact on fertility of the mid-1970s increase in world energy prices—an exogenous shock that substantially increased men’s incomes in the Appalachian coal-mining region. Empirical evidence for that population indicates that fertility is increasing in men’s income. JEL: J13, J40.
HISTOLOGICAL ALTERATIONS IN THE LIVER OF MOTHER RATS AND ITS WEANLINGS FED ON FRIED BREAD AND THE PROTECTIVE EFFECT OF CURCUMIN

This study dealt with the evaluation of the histological alteration due to feeding on fried bread and the protective role of curcumin on the liver of pregnant rats and their offspring. The results showed that feeding on fried bread caused different histopathological lesions in the liver of female rats and their offspring closely similar to those induced by feeding on a diet containing acrylamide. These lesions included vacuolated cytoplasm, dilated blood vessels, congested blood vessels, haemorrhage, pyknosis, necrosis and complete degenerated areas. The emerged data showed that fried bread induced histological alterations in the liver of rats similar to those caused due to acrylamide in food. The present findings suggested that curcumin has slight protective effect against the degenerative effects of fried bread.
Modeling Complex System Testing: Characterizing Test Coverage to Improve Information Return

Abstract : Effective, cost-efficient testing is critical to the long-term success of open architecture within the Navy's Integrated Warfare System. In previous research we have developed a simple, effective framework to examine the testing of complex systems. This model and its prototype decision aid provide a rigorous yet tractable approach to improve system testing, and to better understand and document the system and component interdependencies across the enterprise. An integral part of this model is characterizing test coverages on modules. Using idealized simulations of complex systems, we investigate the sensitivity of test selection strategy to the precision with which these coverages are specified. Monte Carlo analysis indicates that best-test selection strategies are somewhat sensitive to the precision of test coverage specification, suggesting significant impact on testing under fixed-cost constraint. These results provide significant insight as we extend this work with further study of real-world systems by applying, and refining, the mathematical analysis and computer simulation within this framework. The current decision-aid software will be further developed using these operational test and evaluation data, improving the fidelity of the current modeling while making available to program managers and system designers a usable and relevant tool for test-retest decisions.
Retroperitoneal versus transperitoneal approach for nephrectomy in children: Anesthetic implications

Laparoscopic nephrectomy is a popular technique both in adults and children because of its advantages that include less postoperative pain, a shorter hospital stay, better cosmetic results and a quicker return to normal activities. [1] Laparoscopic nephrectomy in children utilizes both transperitoneal (TP) and retroperitoneal (RP) techniques with no clear cut advantage of one over the other. [2] The TP approach offers a large working space and natural orientation to the anatomic landmarks. RP approach offers quicker access to the hilum and is performed in lateral or prone position. However, both techniques have comparable surgical outcome in terms of risk of bowel injury and vascular injury. [3,4] Laparoscopic surgery usually involves abdominal insufflation with carbon dioxide, which has significant cardiovascular and respiratory effects like reduction in oxygen saturation, increase in end-tidal carbon dioxide (ETCO2) and increase in peak airway pressure (PAP). [5] However, whether the type of surgical technique influences the cardiorespiratory parameters is debatable.
Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia‐reperfusion brain injury in the rat

Fractalkine is a neuronally expressed chemokine that acts through its G‐protein‐coupled receptor CX3CR1, localized on microglial and immune cells. Fractalkine might be involved in neuroinflammatory processes secondary to neuronal damage, which normally occur in a time frame of days after ischaemia. We evaluated by in situ hybridization and immunohistochemistry the expression of fractalkine and CX3CR1 in the rat brain, after a transient occlusion of the middle cerebral artery. We found that at 12 h after ischaemia neuronal fractalkine expression was transiently increased in scattered necrotic neurons of the cortex and lost from the ischaemic striatum. At 24 and 48 h after ischaemia, fractalkine immunoreactivity was strongly increased in morphologically intact cortical neurons of the ischaemic penumbra where also the stress‐inducible HSP‐72 was strongly up‐regulated. The intensity of fractalkine immunoreactivity of neurons in the penumbra returned to basal levels at 7 days after ischaemia. Fractalkine synthesis was also induced in endothelial cells of the infarcted area, at 48 h and 7 days after ischaemia. CX3CR1 expression was detected in the activated microglial cells of the ischaemic tissue 24 and 48 h after ischaemia, and became strongly up‐regulated in macrophages/phagocytic microglia inside the infarcted tissue 7 days after ischaemia. These data suggest that fractalkine may participate in the activation and chemoattraction of microglia into the infarcted tissue, and contribute to the control of leucocyte trafficking from blood vessels into the injured area.
Genome Sequences of Potential Probiotic Lactobacillus rhamnosus Isolates from Human Infants

ABSTRACT Probiotics provide health benefits to their hosts, including modulation of host immune response, inhibition of colonization by pathogens, modulation of the gut microbiota, and epithelial barrier enhancement. Here, we present the draft genome sequences of two newly isolated Lactobacillus rhamnosus strains of probiotic potential from healthy human infants.
Biochemical changes in tissue catecholamines and serotonin in duodenal ulceration caused by cysteamine or propionitrile in the rat.

Previous structure-activity and pharmacologic studies with duodenal ulcerogens cysteamine and propionitrile implicating catecholamines in the pathogenesis of duodenal ulceration have now been followed up by dose- and time-response biochemical investigations to assess the importance of monoamines in the development of duodenal ulcers. The concentrations of norepinephrine (noradrenaline), dopamine, serotonin and their metabolites were measured in total brain, brain regions, stomach, duodenum, pancreas and adrenals in the rat. Turnover of catecholamines was determined in rats pretreated with the inhibitor of tyrosine hydroxylase alpha-methyl-p-tyrosine. The duodenal ulcerogens caused a dose- and time-dependent depletion of norepinephrine in virtually all the tissues examined. The effect was maximal 4 or 7 hr after cysteamine or propionitrile, and norepinephrine levels returned to normal in 24 hr. Dopamine changes were selective and often biphasic, e.g., elevation in adrenals, biphasic in brain cortex, hippocampus and midbrain, but uniformly decreasing in glandular stomach and duodenum. In the median eminence dopamine levels decreased by 181 and 324% at 15 and 30 min, respectively, after cysteamine, but neither dopamine nor 3,4-dihydroxyphenylacetic acid was modified in the periventricular nucleus. Serotonin levels were relatively stable, revealing slight elevations or no changes in most of the tissues. The turnover of norepinephrine was accelerated by both chemicals in virtually all brain regions, but dopamine turnover was affected only in a few areas, e.g., in the corpus striatum and medulla oblongata cysteamine decreased dopamine turnover, whereas propionitrile first (at 1 hr) accelerated then (at 8 hr) significantly suppressed it. (ABSTRACT TRUNCATED AT 250 WORDS)
Clinical and serological features of acute sensory ataxic neuropathy with antiganglioside antibodies

There is as yet no consensus for considering pure acute sensory ataxic neuropathy (ASAN) as a variant of Guillain‐Barré syndrome (GBS). Reactivity against gangliosides sharing disialosyl epitopes has been reported in these patients. The aim of this study was to determine the spectrum of reactivity against gangliosides in ASAN and to define the clinical pattern. From our database we identified patients with suspicion of ASAN. We defined ASAN as the presence of ataxia of peripheral origin with loss of proprioception, and areflexia, absence of ophthalmoplegia and no or minimal muscle weakness. Patients who met these criteria were retrospectively reviewed for their spectrum of reactivity against gangliosides and clinical features. We identified 12 patients fulfilling pre‐defined criteria for ASAN. Reactivity against gangliosides containing disialosyl epitopes was present in seven patients. Concomitant reactivity against other gangliosides was present in 6/7 patients. All patients presented good prognosis and an antecedent illness was present in nine. Our results support the previously described clinico‐immunological association between ASAN and disialosyl specificity, and widen the spectrum of reactivity against gangliosides. The acute presentation with a monophasic course, and good prognosis in all cases, together with transient immunoglobulin G antiganglioside antibodies and infectious antecedent in 7/12 patients support the inclusion of ASAN as a GBS variant.
From song dialects to speciation in white‐crowned sparrows

The behavioural signals used in mate selection are a key component in the evolution of premating isolating barriers and, subsequently, the formation of new species. The importance of mating signals has a long tradition of study in songbirds, where many species differ in their song characteristics. In oscine songbirds, individual birds usually learn their songs from a tutor. Mistakes during learning can help generate geographic dialects, akin to those within human language groups. In songbirds, dialect differences can often be substantial and there is an intuitive connection between the evolution of song amongst populations at a small scale, and the more substantive song differences between bird species and presumably used in species recognition. However, studies investigating the concordance between putative genetic and behavioural boundaries have generated mixed results. In many cases, this is possibly a function of the poor resolving power of the genetic markers employed. In this issue of Molecular Ecology, Lipshutz et al. ( ) combine genomic markers with a robust behavioural assay to address the importance of song variation amongst white‐crowned sparrow (Zonotrichia leucophrys) subspecies.
HEMATOLOGICAL AND SERUM BIOCHEMICAL VALUES IN ANESTHETIZED CAPTIVE TASMANIAN DEVILS (SARCOPHILUS HARRISII)

Abstract The Tasmanian devil (Sarcophilus harrisii) population has decreased by estimates of 80% in the past 20 yr due to the effects of devil facial tumor disease (DFTD). In the process of creating a DFTD-free insurance population, the captive population and the number of institutions housing devils worldwide has increased tremendously. In order to provide the best husbandry and veterinary care for these captive animals, it is essential to know normal hematology and biochemistry values for the species. Baseline reference intervals (RIs) were determined for hematology and biochemistry variables for 170 healthy anesthetized captive Tasmanian devils and significant sex and age differences were determined. Higher relative neutrophil counts, hemoglobin, mean corpuscular hemoglobin (MCH), creatinine, creatine phosphokinase, and cholesterol were seen in males compared to females, whereas higher white cell counts (WBC) and lymphocyte counts (absolute and relative) were seen in females. Subadults have higher red blood cell counts, WBC, lymphocytes (absolute and relative), calcium and phosphorus, alkaline phosphatase, glutamate dehydrogenase, glucose, and albumin than adults; whereas, adults have higher relative neutrophils, relative eosinophils, mean corpuscular volume, MCH, platelets, total solids, total plasma proteins, globulins, and chloride than subadults. This study provides a comprehensive report of hematology and serum biochemistry RIs for healthy captive anesthetized Tasmanian devils and offers invaluable diagnostic information to care for the growing captive population of this endangered marsupial.
Memory Representations in Natural Tasks

The very limited capacity of short-term or working memory is one of the most prominent features of human cognition. Most studies have stressed delimiting the upper bounds of this memory in memorization tasks rather than the performance of everyday tasks. We designed a series of experiments to test the use of short-term memory in the course of a natural hand-eye task where subjects have the freedom to choose their own task parameters. In this case subjects choose not to operate at the maximum capacity of short-term memory but instead seek to minimize its use. In particular, reducing the instantaneous memory required to perform the task can be done by serializing the task with eye movements. These eye movements allow subjects to postpone the gathering of task-relevant information until just before it is required. The reluctance to use short-term memory can be explained if such memory is expensive to use with respect to the cost of the serializing strategy.
The relationship of proline content and metabolism on the productivity of maize plants

The free proline content in maize ear-leaves, silk and pollen were analyzed in field grown plants which had matured to the pollination stage. Using maize hybrids PR34F02, PR35P12 and PR36B08 field trials were set up at two locations in eastern Croatia in two different years. Two enzymes of proline metabolism were analyzed in the same leaf samples and specific activities of synthetase (P5CS) and proline dehydrogenase (PDH). Plant productivity was evaluated at harvest by the estimation of total and fully developed grain number per ear and per plant, the mean single grain mass, and the mass of grain per plant. The year in which the plants were grown had a very significant effect on the free proline content in the leaf and pollen, as well as on the enzyme activities assayed. The differences between the plants from the two localities were very significant in all tested parameters of plant grain productivity. There was a significant genotype effect on proline content and P5CS total activity in leaf and on all the productivity parameters. Some of the correlations established suggest that the rate of proline synthesis and degradation in maize ear-leaf at pollination might contribute to the final grain production of the maize plant. Multiple regression analyses was used to further analyze the relationship between proline and grain productivity, but it is clear that future work should include other environmental conditions, plant species and organs such as roots.
The role of the AR/ER ratio in ER-positive breast cancer patients.

The significance of androgen receptor (AR) in breast cancer (BC) management is not fully defined, and it is still ambiguous how the level of AR expression influences oestrogen receptor-positive (ER+) tumours. The aim of the present study was to analyse the prognostic impact of AR/ER ratio, evaluated by immunohistochemistry (IHC), correlating this value with clinical, pathological and molecular characteristics. We retrospectively selected a cohort of 402 ER+BC patients. On each tumour, IHC analyses for AR, ER, PgR, HER2 and Ki67 were performed and AR+ cases were used to calculate the AR/ER value. A cut-off of ≥2 was selected using receiver-operating characteristic (ROC) curve analyses. RNA from 19 cases with AR/ER≥2 was extracted and used for Prosigna-PAM50 assays. Tumours with AR/ER≥2 (6%) showed more frequent metastatic lymph nodes, larger size, higher histological grade and lower PgR levels than cases with AR/ER<2. Multivariate analysis confirmed that patients with AR/ER≥2 had worse disease-free interval (DFI) and disease-specific survival (DSS) (hazard ratios (HR) = 4.96 for DFI and HR = 8.69 for DSS, both P ≤ 0.004). According to the Prosigna-PAM50 assay, 63% (12/19) of these cases resulted in intermediate or high risk of recurrence categories. Additionally, although all samples were positive for ER assessed by IHC, the molecular test assigned 47.4% (9/19) of BCs to intrinsic non-luminal subtypes. In conclusion, the AR/ER ratio ≥2 identifies a subgroup of patients with aggressive biological features and may represent an additional independent marker of worse BC prognosis. Moreover, the Prosigna-PAM50 results indicate that a significant number of cases with AR/ER≥2 could be non-luminal tumours.
Analytical and Numerical Study on the Characteristics at the  $\alpha{-}\gamma$ Transition Point in Radio-Frequency Helium Discharges at Atmospheric Pressure

It is well accepted that increasing the frequency and reducing the electrode gap are effective ways to enhance the discharge stability in atmospheric radio-frequency (rf) discharges. In this paper, we explore a 1-D fluid model to investigate the discharge characteristics when the α-γ mode transition occurs. The differential equation satisfied at the α-γ mode transition point is given based on the governing equations. From the theoretical analysis and computational data, with an increase in the electrode gap, the power density coupled to the plasmas decreases, and the critical electron density modestly increases at the transition point; the electron temperature both in the sheath and bulk plasma decreases as the sheath shrinks. On the other side, as the frequency is raised, just at the mode transition point, the applied voltage reduces, and the plasma density increases almost exponentially with a higher electron temperature in the sheath. From the view point of application, the discharge driven by a high frequency at a narrow gap is desirable to produce a stable and high-density atmospheric plasma with a large power density coupled.
Review of guidelines on primary prevention of cardiovascular disease with aspirin: how much evidence is needed to turn a tanker?

Aims There are numerous national and international guidelines on the use of aspirin for the primary prevention of cardiovascular disease. Given the uncertainties about aspirin in primary prevention, our aim was to compare the recommendations and the reported evidence in guidelines for the treatment with aspirin of subjects free of cardiovascular disease with or without diabetes. Methods and Results Guidelines were retrieved through Medline and other electronic databases and through a web-based search for guideline development organizations. The content of the recommendations and the underlying evidence were analysed with qualitative and bibliometric methods. In addition, we searched for recent studies to assess whether they underscore the current recommendations. We included 12 guidelines: six European, three North American, and one each from New Zealand, Australia, and the World Health Organization. Recommendations differ with regard to outcome (morbidity, mortality), time span (years of risk), cut-off percentage between high and low risk, and the dose of aspirin. Most guidelines are not in line with recent evidence, which show that aspirin is of uncertain net value as the reduction in absolute risk for occlusive CV events needs to be weighed against an increase in the risk of major bleeds. Conclusion We found conflicting recommendations in various guidelines about the use of aspirin for the primary prevention of cardiovascular events, which reflect differences in selection of the evidence and in the timing of publication. According to recent evidence, in general, the use of aspirin seems no longer justifiable in primary prevention in patients with or without diabetes.
The evidence-based health care debate - 2006. Where are we now?

Correspondence Professor Andrew Miles Centre for Health Sciences Institute of Health Sciences Education Bart’s and The London Queen Mary’s School of Medicine and Dentistry c/o PO Box LB48 Mount Pleasant Royal Mail Centre Farringdon Road London EC1A 1LB UK E-mail: andrew.miles@keyadvances.org. uk
Achieving better peer interaction in online discussion forums: A reflective practitioner case study

This paper documents the initial phase of a research project to improve peer interaction in a discussion forum for a Spatial Sciences class (unit) at Curtin University. A number of strategies were implemented to redress the low levels of online participation prevailing for a number of years. Three research questions were formulated to evaluate the effectiveness of teaching and learning initiatives. The analysed statistical data for this unit obtained from Blackboard revealed positive correlations between students’ results and their participation in the discussions forum, which was supported by students’ comments on the forum. The statistical measures used offered a way of ensuring a more objective evaluation of the effectiveness of the changes, with evidence of promising improvements in participation levels. The initiatives of offering incentives to participate in the discussion forum and creating a positive community environment appear to have marginally increased levels of achievement.