Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuropsychologic Outcomes in Patients Treated for Complex Maxillofacial Trauma

Abstract Complex fractures of the craniofacial skeleton are caused most commonly, in Australia, by motor vehicle accidents, falls, and interpersonal violence. Significant force is required to fracture the facial skeleton, and the long-term effect these forces have on higher brain function is unclear. The study aim was to assess long-term neuropsychologic changes associated with complex fractures of the facial skeleton. Patients managed for complex fractures of the facial skeleton by the Australian Craniofacial Unit, South Australia, between 2002 and 2011, with at least 1-year follow-up, were assessed using the European Brain Injury Questionnaire. This questionnaire has previously published control data to which results were compared. Of the 2077 patients treated for facial fractures, 46 were identified as having complex fractures of the facial skeleton. Of the 46 patients, 13 were able to be contacted and assessed using the European Brain Injury Questionnaire. Changes in personality and ability to socialize and undertake executive function were noted in approximately 30% of the patients. In addition, approximately 50% of the patients’ family members reported significant changes in the patients’ life after the accident, yet this was only recognized by approximately 30% of the patients. This study shows that, despite the “crumple zone” of the facial skeleton providing some level of protection to the brain, patients having complex fractures of the facial skeleton have long-term neuropsychologic changes that affect both their own and their family’s quality of life.
Randomized Comparison of a Silicone Tape and a Paper Tape for Gentleness in Healthy Children

PURPOSE: To compare the relative gentleness of a silicone tape to a paper tape in healthy infants and children. DESIGN: A randomized, grader-blinded, comparative study. SUBJECTS AND SETTING: The sample group comprised 24 healthy infants and children 9.1 to 46.7 months of age (mean ± SEM, 34.0 ± 2.21). The study was conducted at a dermatological research facility (cyberDERM, Inc) located in Broomall, Pennsylvania. All volunteers were recruited from the surrounding community. METHODS: Tapes measuring 1 × 1.5 inches were randomly applied to the left and right intrascapular regions of the upper back. Tapes were removed in a standardized fashion after 24 hours. The primary study outcome, gentleness, was based on visual assessments of skin damage, discomfort, and quantification of keratin removal. Four-point scales were used to assess skin damage, and a 10-point Faces, Legs, Activity, Cry, and Consolability instrument was used to assess discomfort. Secondary assessments included hair removal, tape edge-lift assessments, and parent preference for either tape. RESULTS: There was a significantly lower mean ± SEM erythema response for the silicone tape (0.93 ± 0.14 vs 1.35 ± 0.11, P = .0129) than for the paper tape. No measurable epidermal stripping occurred with the silicone tape compared to a mean ± SEM response of 0.29 ± 0.11 for the paper tape (P = .0039). Discomfort was significantly lower (P = .0002) for the silicone tape as compared to the paper tape (Faces, Legs, Activity, Cry, and Consolability score mean difference from baseline 0.5 vs 3.3, P = .0002). Keratin removal was significantly less with the silicone as compared to paper tape (8.7 ± 0.5 &mgr;g/mL vs 15.2 ± 1.3 &mgr;g/mL, P < .0001). Few hairs were removed with either tape. There was significantly less (P < .0001) edge-lift with the paper tape than the silicone tape; no statistically significant differences in parent preferences for silicone versus paper tapes were measured (P = .3359). CONCLUSIONS: Gentleness assessments favored the silicone tape compared to a paper tape and warrant further clinical investigation in the neonatal intensive care unit.
What Factors Influence the Individual Impact of the Web? An Initial Model

Over the past ten years the use of the World Wide Web has changed significantly. Building a site that meets customer requirements requires a deep understanding of what different types of customers want to accomplish online. User information satisfaction instruments and use quality models have to be renewed as the Web has changed the way users and organizations interact with information systems (Lindroos 1997). An efficient and scalable e-commerce environment is one of the primary keys to success. The purpose of this research is to propose a model of Web success for individuals (users), and then assess the individual impact of the Web in relation to the proposed factors. From a sample of 188 subjects, the results of the model show that the individual impact of the Web is influenced by its usefulness and the content/timeliness. In this study, usability of the Web is influenced by temporal dissociation, enjoyment and control but not by race, age, gender or institution-based trust, while cognitive absorption is influenced by playfulness but not by personal innovativeness.
Predicting Acquisitions in India

Statistical models for predicting takeover targets by using publicly available information, specifically historical accounting information, has attracted considerable academic endeavour. These empirical studies draw from the stylized fact that has unequivocally emerged from literature on performance of mergers and acquisitions: that target firms gain abnormal returns when a takeover announcement is made. Hence, it has been hypothesized that early prediction of takeover targets can stimulate strategic trading that can consistently ‘beat the market’, and make abnormal returns. While it has now been generally proven that such a strategy cannot succeed within semi-strong efficient markets, attempts continue to construct such prediction models to identify potentially valuable firms that can at least provide higher returns under a new management with synergistic propositions. Besides, the characteristics identified by a robust model are also used for preliminary exploration for a potentially good target by acquirers. Following this strand of literature, this paper builds a prediction model for acquisition targets in India using logistic regression. For the estimation of the logistic regression, 122 target firms of acquisitions during the three year-period from 2002 to 2005 were considered, and matched with non-acquiring, non-target firms that had similar promoters' holdings and belonged to the same industry as the target. Results from logistic regression indicate that, a typical target is inherently strong with high growth and large free cash flow, in spite of high debt levels, but encumbered by an inefficient management, who are probably disciplined by takeover market. Traditional determinants of US and UK studies, viz., size and growth-resource imbalance are not significant in the Indian context. Methodological care was taken at various steps to avoid known biases. Estimation period was taken for a modest three year period rather than a longer period to ensure minimal changes in the macro-economic landscape that might have a bearing on the target characteristics. Further, both raw accounting ratios, and industry adjusted ratios were used to account for non-normality of such data. To build the prediction model, cut-off values were calculated using two methods, one that minimized statistical errors and another that maximized returns; again, the latter was found to be superior. Finally, the prediction model was tested on an out-of-sample database of acquisitions that took place during 2005-2006 and was found to yield prediction accuracies up to 91 per cent.
Risk factors for spontaneous preterm delivery after arrested episode of preterm labor

Abstract Introduction: We aimed to identify specific risk factors for spontaneous preterm delivery (PTD) among women with arrested preterm labor (PTL). Method: A retrospective study of women admitted due to imminent PTL and intact membranes, which did not progress to PTD within 24 h from admission. Eligibility was limited to singleton gestations at 24 + 0/7–33 + 6/7 weeks of gestations with no known chromosomal or structural anomalies. All women were treated with corticosteroids and tocolysis. Comparison was made between those who delivered at <37 + 0/7 weeks of gestation (study group) to women who delivered at ≥37 + 0/7 weeks of gestation (controls). Results: Overall, 301 women were recruited, of which 85 (28.2%) delivered before 37 + 0/7 weeks and 216 (71.8%) delivered at term. Advanced cervical dilatation was found to be an independent risk factor for PTD [for women with no past PTD: adjusted odds ratio (aOR) 1.66, 95% CI: 1.06–2.61 for each 1 cm dilatation; for women with past PTD: aOR 2.81, 95% CI: 1.02–7.73 for each 1 cm dilatation]. Among women without past PTD, additional independent risk factors for PTD were earlier gestational week at admission (OR: 1.20, 95% CI: 1.09–1.32 for each earlier week) and short cervical length (OR: 1.04, 95% CI: 1.01–1.08 for each decrease of 1 mm in cervical length). Conclusion: Advanced cervical dilatation, earlier gestational age at the episode of arrested PTL, and short cervical length are specific risk factors for PTD in women with arrested PTL. These findings may assist in counseling women and direct further investigation.
ASYMMETRIC RESPONSE PATTERNS TO SUBSPECIES‐SPECIFIC SONG DIFFERENCES IN ALLOPATRY AND PARAPATRY IN THE GRAY‐BREASTED WOOD‐WREN

Song divergence between closely related taxa may play a critical role in the evolutionary processes of speciation and hybridization. We explored song variation between two Ecuadorian subspecies of the gray‐breasted wood‐wren (Henicorhina leucophrys) and tested the impact of song divergence on response behaviors. Songs were significantly different between the two subspecies, even between two parapatric populations 10 km apart. Playback experiments revealed an asymmetric response pattern to these divergent subspecies specific songs; one subspecies responded more to songs of its own subspecies than to the other subspecies’ songs, whereas the second responded equally strongly to songs of both subspecies. While song parameters revealed a mixed pattern of divergence between allopatric and parapatric populations, the majority of spectral characteristics showed increased divergence in parapatry, suggestive of character displacement. This increased song divergence in parapatry appeared to affect behavioral responses to playback as discriminating responses were most prominent in parapatry and against parapatric songs. The clear behavioral impact of subspecies‐specific song differences supports a potential role for song as an acoustic barrier to gene flow. The asymmetric nature of the responses suggests that song divergence could affect the direction of gene flow and the position of the subspecies‐specific transition.
Knee extensor strength, activation, and size in very elderly people following strength training

Muscle strength, activation, and size were studied in 11 very elderly subjects (8 women and 3 men; age range, 85–97 years) who completed 12 weeks of strength training of the knee extensor muscles. Training increased the maximum amount of weight that could be lifted once (134%; P < 0.05) and maximum voluntary isometric strength, measured as both force recorded at the ankle with the knee flexed 90° (17%, ns) and as torque with the knee flexed 60° (37%; P < 0.05). Anatomical lean quadriceps cross‐sectional area (LCSA) measured at midthigh using magnetic resonance imaging increased from 27.5 ± 9.6 cm2 to 30.2 ± 10.0 cm2 (9.8%; P < 0.05) after training. Both before and after training, isometric strength was closely related to LCSA, but training resulted in no significant change in muscle force per unit area of quadriceps muscle. Using the twitch interpolation technique, muscle activation during a maximal voluntary isometric contraction was shown to be incomplete in all subjects before training (ranging from 69% to 93%) and was not significantly increased after training. An increase in skeletal muscle mass may have important functional and metabolic benefits for very elderly people. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 831–839, 1999
Uptake of Re ( VII ) from aqueous solutions by Bacillus sp . GT-83-23

a Department of Nuclear Biotechnology, Nuclear Science Research School, Nuclear Science and Technology Research Institute, North Karegar Street, P.O. Box 11365-3486, Tehran, Iran b Department of Microbiology, Faculty of Science, Az-Zahra University, Tehran, Iran c Van de Graff Laboratory, Nuclear Science Research School, Nuclear Science and Technology Research Institute, P.O. Box 11365-3486, Tehran, Iran
Patterns of outcome of caregiving for the impaired elderly: A longitudinal study in rural Japan

This longitudinal study investigates the experiences among Japanese caregivers who provide informal care at home to the impaired elderly over one year. Little is known about longitudinal changes in caregivers' burden in Japan. Between 1998-1999, 47 pairs of impaired elderly and their caregivers were followed in Matsuyama Town in a rural area of northern Japan. Caregivers were interviewed initially and then again 12 months later. Findings indicated that the mean score of the Zarit Burden Interview at Time 2 was significantly lower than that of Time 1, suggesting that caregivers adapted to their role over time. Outcomes were further categorized as successful and unsuccessful, depending on the pattern of change over one year. Two factors were related to the outcome in univariate analyses: caring for someone with dementia, and caregiver being a spouse. Logistic regression demonstrated that caring for someone with dementia was five times more likely to be associated with an unsuccessful outcome. The caregiver spouse was five times more likely to be associated with a successful outcome, while daughters-in-law were more likely to have an unsuccessful outcome. The present study suggests that (1) changes in well-being among caregivers in Japan are similar to those observed in most studies in the West, and (2) there was evidence of both the adaptation and wear-and-tear models among caregivers over time.
Imaging features of metaplastic carcinoma with chondroid differentiation of the breast.

OBJECTIVE The purpose of this study was to evaluate the imaging features--including the mammographic, sonographic, MRI, and bone scintigraphic findings--in 12 patients with metaplastic carcinoma with chondroid differentiation of the breast and to correlate the imaging findings with the pathologic features. CONCLUSION Metaplastic carcinoma with chondroid differentiation of the breast manifests as a palpable mass and should be included in the differential diagnosis of a large indistinct highdensity mass with amorphous or coarse calcifications on mammography and a relatively circumscribed complex echoic mass with posterior enhancement on sonography. A relatively circumscribed mass with a nonenhancing T2 intermediate- to high-signal-intensity internal component on MRI and an area of intense uptake of 99mTc methylene diphosphonate (MDP) on bone scintigraphy might be useful in suggesting the diagnosis of metaplastic carcinoma with chondroid differentiation.
Epigenetic Regulation of Pericentromeric Heterochromatin during Mammalian Meiosis

Mammalian meiosis is a process that allows diploid progenitor germ cells to produce haploid gametes after proceeding through 2 rounds of cell divisions. The first division (MI) is unique and results in the separation of homologous chromosomes, while the second division (MII) leads to the separation of sister chromatids similar to a somatic cell division. However, the mechanisms by which meiotic cells regulate their 2 very different cell divisions are not well understood. We postulated a role for epigenetic chromatin modifications in regulating these processes. We found prior to the onset of MI that pericentromeric heterochromatic regions, which are enriched with histone H3K9me2 throughout meiosis, become enriched at late pachytene with H3S10ph and at diplotene with H4K5ace and H4K16ace, but remain underacetylated at other sites examined. RNA polymerase II, which is clearly excluded from pericentromeric heterochromatin at pachytene, becomes exclusively associated with these regions from diplotene to MI. By contrast, pericentromeric heterochromatic regions at MII are not engaged by RNA polymerase II nor enriched with H3S10ph. Furthermore, we found DICER to localize exclusively to pericentromeric heterochromatin at MI, but not MII. These results are significant since they suggest: (1) that distinct chromatin modifications differentiate the 2 meiotic divisions; (2) a role for repetitive DNA elements and RNAi in mammalian meiosis; (3) H3K9me2 is not sufficient to block RNA polymerase II elongation through heterochromatin, and (4) H3S10ph provides a ‘binary switch’ to activate transcription in heterochromatin.
Sequential volume mapping for confirmation of negative growth in vestibular schwannomas treated by gamma knife radiosurgery.

OBJECT The purpose of this study was to confirm, by using a sequential volume mapping (SVM) technique, that gamma knife radiosurgery (GKS) induces negative growth in vestibular schwannomas (VS). METHODS Over a period of 5 years, 126 small- to medium-sized (< 15 cm3) VSs were treated using microradiosurgical techniques within a standard protocol. All patient data were collected prospectively. Sequential magnetic resonance imaging was performed every 6 months to assess the volume of the tumor, based on specially developed GammaPlan software. The mean follow-up duration was 22 months. At least three SVM measurements were obtained in 91 patients and at least four were obtained in 62 patients. The mean number of SVM measurements for each patient was 2.54. After GKS, the following patterns of volume change were seen: 1) 57 VSs showed transient increase in volume with a peak at 6 months, followed by shrinkage. Four VSs exhibited prolonged swelling beyond 24 months. Transient swelling and eventual shrinkage were independent of the initial VS volume; 2) 29 VSs showed direct volume shrinkage without swelling; and 3) five VSs showed persistent volume increase. All volume changes were greater than 10%. The overall mean volume reduction was 46.8% at 30 months. CONCLUSIONS Sequential volume mapping appears to be superior to conventional two-dimensional measurements in monitoring volume changes in VS after GKS. It confirms that transient swelling is common. Ninety-two percent of tumors responded by showing significant volume shrinkage (mean 46.8%). It would seem that GKS can induce volume reduction in VS.
Subchronic sleep restriction causes tissue-specific insulin resistance.

CONTEXT Short sleep duration is associated with an increased risk of type 2 diabetes. Subchronic sleep restriction (SR) causes insulin resistance, but the mechanisms and roles of specific tissues are unclear. OBJECTIVE The purpose of this article was to determine whether subchronic SR altered (1) hepatic insulin sensitivity, (2) peripheral insulin sensitivity, and (3) substrate utilization. DESIGN This was a randomized crossover study in which 14 subjects underwent 2 admissions separated by a washout period. Each admission had 2 acclimatization nights followed by 5 nights of either SR (4 hours time in bed) or normal sleep (8 hours time in bed). MAIN OUTCOME MEASURE/METHODS: Insulin sensitivity (measured by hyperinsulinemic-euglycemic clamp) and hepatic insulin sensitivity (measured by stable isotope techniques) were measured. In addition, we assayed stress hormone (24-hour urine free cortisol, metanephrine, and normetanephrine), nonesterified fatty acid (NEFA), and β-hydroxybutyrate (β-OH butyrate) levels. Resting energy expenditure (REE) and respiratory quotient (RQ) were measured by indirect calorimetry. RESULTS Compared to normal sleep, whole-body insulin sensitivity decreased by 25% (P = .008) with SR and peripheral insulin sensitivity decreased by 29% (P = .003). Whereas hepatic insulin sensitivity (endogenous glucose production) did not change significantly, percent gluconeogenesis increased (P = .03). Stress hormones increased modestly (cortisol by 21%, P = .04; metanephrine by 8%, P = .014; normetanephrine by 18%, P = .002). Fasting NEFA and β-OH butyrate levels increased substantially (62% and 55%, respectively). REE did not change (P = 0.98), but RQ decreased (0.81 ± .02 vs 0.75 ± 0.02, P = .045). CONCLUSION Subchronic SR causes unique metabolic disturbances characterized by peripheral, but not hepatic, insulin resistance; this was associated with a robust increase in fasting NEFA levels (indicative of increased lipolysis), decreased RQ, and increased β-OH butyrate levels (indicative of whole-body and hepatic fat oxidation, respectively). We postulate that elevated NEFA levels are partially responsible for the decrease in peripheral sensitivity and modulation of hepatic metabolism (ie, increase in gluconeogenesis without increase in endogenous glucose production). Elevated cortisol and metanephrine levels may contribute to insulin resistance by increasing lipolysis and NEFA levels.
Open innovation in multinational companies' subsidiaries: the role of internal and external knowledge

The mainstream literature on innovation management has recognised that most organisations can and must innovate using both internal and external knowledge sources. The management of knowledge in multinational companies (MNCs) implies that subsidiaries should achieve centrality because they are in the unique position to tap into many different sources of knowledge from different cultural contexts. In this context, this paper aims to highlight the importance of 'openness' at the subsidiary level, combining both external and internal knowledge (within the MNC but outside the subsidiary). To do so, we test the single and joint effects of external and internal 'openness' on subsidiaries' innovation performance. Using Amadeus databases, 163 subsidiaries were selected and data were collected through a standardised questionnaire. Then, three hypotheses were tested through an OLS regression model. The results indicate that external and internal knowledge openness positively affects subsidiaries' innovation performance. Moreover, the inclusion of the interaction term shows that a high level of both leads to a multiplicative and positive effect. The findings are discussed in the light of the extant literature, and several implications for future research and MNC and subsidiary managers are highlighted.
Evaluation of the Contribution of Clinical Pharmacists: Inpatient Care and Cost Reduction

Clinical pharmacists in this study hospital reported 1027 interventions in patient drug therapy over two time periods of three and two weeks, respectively. These interventions were subjected to self and peer reviews and to cost-avoidance evaluation. The most frequent type of intervention was recommendations related to drug selection (29.6 percent). Recommendations were not implemented by physicians in only 10.2 percent of the cases. The perceived impact of these interventions on the quality, cost, or both was found by the peer reviewers to occur in 58.5, 16.1, and 25.6 percent of the cases, respectively. Also, when peer reviewed for clinical significance, 983 of these interventions were judged to improve drug therapy to an acceptable level based on the professional literature, and 36 were deemed very significant in terms of saving patients' lives or preserving major organ functions. Of the 983 interventions rendering drug therapy to an appropriate level, 398 were deemed to have cost-avoidance impact; of this number a 25 percent random sample was subjected to cost-avoidance evaluation. Realized cost-avoidance averaged $242 for each intervention implemented. When extrapolated annually, $364 900 was the net realized cost-avoidance after discounting for the cost of providing clinical pharmacy services. An average cost-avoidance of $860.50 was calculated for each intervention made by pharmacists, but not followed by physicians, for an annual potential cost-avoidance of $532 650. In all, clinical pharmacists had the potential to save $897 550 annually in hospital resources if all their interventions had been accepted and implemented.