Miracle-dz/UniFAR-FTUs huggingface dataset:
Barrier functionals for output functional estimation of PDEs

We propose a method for computing bounds on output functionals of a class of time-dependent PDEs. To this end, we introduce barrier functionals for PDE systems. By defining appropriate unsafe sets and optimization problems, we formulate an output functional bound estimation approach based on barrier functionals. In the case of polynomial data, sum of squares (SOS) programming is used to construct the barrier functionals and thus to compute bounds on the output functionals via semidefinite programs (SDPs). An example is given to illustrate the results.
Evolving Macroeconomic Dynamics in a Small Open Economy: An Estimated Markov Switching DSGE Model for the UK

This paper investigates the possibility of shifts in the UK economy using a Markov switching open economy dynamic stochastic general equilibrium (DSGE) model. We find overwhelming evidence to reject the hypothesis that the deep structural parameters of the underlying structural model had stayed constant throughout the sample period and there is significant changes to the volatility of the structural shocks. Counterfactual experiments based on the model with the best empirical fit indicate that the change in the policy rule as well as changes to the volatility of the structural shocks over the sample period are crucial features in explaining UK’s macroeconomic performance.
In Vitro Effects of Cyclosporine A and Tacrolimus on Regulatory T-Cell Proliferation and Function

Background Liver transplantation is the treatment of end-stage liver diseases, including hepatitis C. Immunosuppression prevents graft rejection but seems to accelerate the recurrence of hepatitis C. Regulatory T cells (Tregs) may be beneficial in tolerance but deleterious in recurrent hepatitis C. We evaluated the effects of cyclosporine or tacrolimus, the principal immunosuppressive drugs, on Treg proliferation and function. Methods Human Tregs were isolated from healthy donors and cultured with cyclosporine, tacrolimus, or NIM811, a cyclosporine analog devoid of calcineurin-inhibiting activity. Treg proliferation and suppressive activity were assessed. The phenotype, cytokine production, and phosphorylation profile of nuclear factor of activated T cell of Tregs were also analyzed. Results Cyclosporine and tacrolimus both decreased Treg proliferation, but only low doses of cyclosporine reduced Treg activity, by inducing the production of interleukin 2 proinflammatory cytokines in these cells. Moreover, NIM811 also inhibited Treg activity. The phosphorylation of nuclear factor of activated T cell in Tregs was not altered by cyclosporine, suggesting that the effects of this drug are independent of the calcineurin pathway. Conclusion In summary, low doses of cyclosporine inhibit Treg activity, a finding that might explain the beneficial effect of this drug on hepatitis C recurrence. In contrast, by maintaining Treg activity, tacrolimus could be more helpful than cyclosporine in controlling rejection.
Unique gene expression and clinical characteristics are associated with the 11q23 deletion in chronic lymphocytic leukaemia

Chromosome abnormalities influence prognosis and tumour progression in B‐cell Chronic Lymphocytic Leukaemia (CLL). This study sought to determine whether these different disease subgroups were associated with unique gene expression patterns. Thirty‐four cases of CLL were screened for the 11q23, 13q14, 17p13 deletions, and trisomy 12 by fluorescence in situ hybridization (FISH). Expression of 205 cell signalling and apoptosis genes were compared by cDNA array among cases with different chromosome abnormalities. A majority of the statistically differentially expressed genes were present in the 11q23 deletion group by hierarchical clustering. CDC2, a serine/threonine kinase, was overexpressed in the 11q23 deletion group (P = 0·0004) and confirmed by TaqmanTM real‐time polymerase chain reaction. Several other genes associated with cell signalling were overexpressed in the 11q23 deletion group. A strong overall correlation existed between the presence of different chromosome abnormalities and a number of prognostic factors including immunoglobulin heavy chain variable region mutation status (P = 0·011), time to treatment (P = 0·025) and lymphocyte doubling time (P = 0·034). This study confirmed the prognostic impact of chromosome abnormalities identified by FISH in CLL, particularly the 11q23 deletion and trisomy 12. In addition, the 11q23 deletion group was associated with a unique gene expression pattern involving cell signalling and apoptosis genes.
The U-line balancing problem

The traditional line balancing LB problem considers a production line in which stations are arranged consecutively in a line. A balance is determined by grouping tasks into stations while moving forward or backward through a precedence network. Recently many production lines are being arranged in a "U-line," as a consequence of the use of just-in-time production principles in many factories. In this paper the U-line LB problem is introduced and modelled, and solution procedures are developed. It more complex than the traditional LB problem because tasks can be grouped by moving forward, backward, or simultaneously in both directions, through the precedence network. We also show how solution techniques developed for the traditional LB problem can be adapted for use with the new problem. Some computational results for well-known problems from the literature are given.
The common trend and the cross-section of expected returns

In order to explain the variation of the cross-section of expected returns, we consider a long-run beta which takes account of the common stochastic trends between stock prices. Using the same data as those used by Fama and French (1992), it is found that the long-run beta shows an explanatory potential of the variation of the cross-sectional average returns.
Evaluation of the reference yield calculation method in crop insurance

Purpose - This article seeks to examine the reference yield calculation method used in crop insurance rating and provides recommendations that could potentially improve actuarial performance of the Federal crop insurance program. Design/methodology/approach - Conceptual, numerical, and statistical analysis is utilized to evaluate the reference yield calculation method used in the US Federal crop insurance program. Findings - The results suggest that reference yields, which at the time of this study are calculated using National Agricultural Statistics Service (NASS) data, do not accurately represent the average actual yields of the insured pool of producers in the Federal crop insurance program. In addition, it is found that not regularly updating these NASS-based reference yields exacerbates this problem because these reference yields do not appropriately represent the current state of technological progress. Practical implications - The empirical analysis leads this paper to recommend a reference yield calculation procedure that utilizes county-average yields from the risk management agency (RMA) participation database and an approach that uses spatially aggregated average yields in cases when data for a particular county are sparse. Originality/value - No previous study has investigated the reference yield calculation method in the Federal crop insurance program using both RMA and NASS data sets. Moreover, this study contributes to the small literature that examines various aspects of the actual production history (APH) rating platform and suggests refinements to improve actuarial performance.
Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons

Neurogenesis of projection neurons requires that axons be initiated, extended, and connected. Differences in the expression of axon growth and guidance genes must drive these events, but comprehensively characterizing these differences in a single neuronal type has not been accomplished. Guided by a catalog of gene expression in olfactory sensory neurons (OSNs), in situ hybridization and immunohistochemistry revealed that Cxcr4 and Dbn1, two axon initiation genes, marked the developmental transition from basal progenitor cells to immature OSNs in the olfactory epithelium. The CXCR4 immunoreactivity of these nascent OSNs overlapped partially with markers of proliferation of basal progenitor cells and partially with immunoreactivity for GAP43, the canonical marker of immature OSNs. Intracellular guidance cue signaling transcripts Ablim1, Crmp1, Dypsl2, Dpysl3, Dpysl5, Gap43, Marcskl1, and Stmn1–4 were specific to, or much more abundant in, the immature OSN layer. Receptors that mediate axonal inhibition or repulsion tended to be expressed in both immature and mature OSNs (Plxna1, Plxna4, Nrp2, Efna5) or specifically in mature OSNs (Plxna3, Unc5b, Efna3, Epha5, Epha7), although some were specific to immature OSNs (Plxnb1, Plxnb2, Plxdc2, Nrp1). Cell adhesion molecules were expressed either by both immature and mature OSNs (Dscam, Ncam1, Ncam2, Nrxn1) or solely by immature OSNs (Chl1, Nfasc1, Dscaml1). Given the loss of intracellular signaling protein expression, the continued expression of guidance cue receptors in mature OSNs is consistent with a change in the role of these receptors, perhaps to sending signals back to the cell body and nucleus. © 2010 Wiley‐Liss, Inc.
FACTORS INFLUENCING MINORITY AND NON-MINORITY STUDENTS TO ENROLL IN AN INTRODUCTORY AGRISCIENCE COURSE IN TEXAS

The authors investigated attitudes toward agriculture of minority and non-minority students to identify reasons for enrolling and perceived enrollment barriers. A stratified random sample of all students enrolled in two introductory agriscience courses in 60 agriscience programs was selected and surveyed using a five-part questionnaire. The major findings and conclusions were that: 1) the majority of students and teachers were white males; 2) minority students, especially minority females, were underrepresented; 3) minority students tended to be from non-farm, non-rural areas; and, 4) minority students had more negative perceptions regarding agriculture and agricultural education, and were more likely to perceive their reasons for enrolling as being beyond their control, perceived more barriers to enrolling, and were less likely to see opportunities for themselves in agricultural careers or to perceive agriculture as diverse. The following recommendations were offered: 1) the agricultural education profession should focus awareness and informational activities on the elementary grades and should conduct recruitment activities no later than the middle school grades; 2) efforts should be conducted to recruit more minorities into agriscience teaching; and, 3) activities should be conducted to reduce the perceived barriers for minority students.
A longitudinal functional magnetic resonance imaging study of task control circuits and bulimic symptoms over adolescence

BACKGROUND Previous cross-sectional findings from adolescents and adults with Bulimia Nervosa (BN) suggest disturbances in fronto-striatal and cingulo-opercular task control circuits that support self-regulatory processes, including the resolution of cognitive conflict. Herein, we used longitudinal data to examine the developmental trajectories of such disturbances and how the functioning of these circuits relates to changes in BN symptoms over adolescence. METHODS Thirty-two adolescent females with BN symptoms and 28 healthy control (HC) adolescents participated in the study. Functional magnetic resonance images (fMRI) during performance of a Simon task were acquired at three time points within 2-year intervals over adolescence. From the initial sample, 70% and 30% of the participants completed the second and third time points, respectively. Participants who completed all study time points did not differ from those lost to attrition on baseline demographic characteristics or any outcome measures. Using a region-of-interest approach, growth curve models tested group differences in the trajectory of conflict-related activation in task control circuits over time. Cross-lagged panel models examined transactional relationships between conflict-related activation in the same regions and BN symptoms over time. RESULTS Growth curve models revealed different trajectories of conflict-related activation in right task control regions across BN and HC adolescents, such that HC but not BN adolescents showed activation decreases over time. These group differences were greatest when including only the BN adolescents whose symptoms remitted over time. Cross-lagged panel models revealed that less frequent bulimic episodes at first follow-up predicted later increases in conflict-related activation in bilateral task control regions. CONCLUSIONS These longitudinal findings suggest overengagement of task control circuits in BN adolescents, especially those most resilient to persistent illness. Such overengagement may compensate for regulatory disturbances, allowing them to regulate eating behaviors over development. Thus, task control circuits may constitute targets for early interventions that enhance self-regulatory control.
Human capital resources and requirements across the metropolitan hierarchy of the USA

This article is devoted to an investigation of the forms of human capital that characterize cities at different levels of the US urban hierarchy. Basic data on human capital are drawn from the O*Net information system. A first analytical exercise shows that for the USA as a whole, occupations marked by broadly cognitive human capital assets gained in employment over the period from 2000 to 2006, whereas employment in occupations marked by broadly physical human capital assets declined. These same types of assets bear a distinctive relationship to the urban hierarchy, with the former being concentrated in large metropolitan areas, and the latter in small. Changes in these assets over the 2000–2006 period are then examined. Surprisingly, cognitive assets increased most strongly in small metropolitan areas and physical assets increased most strongly in large. Further analysis of these findings suggests that they are quite consistent with a wider view of the contemporary urban economy. In particular, in large metropolitan areas, expanding human capital assets focused on the physical abilities of workers has nothing to do with the ‘old’ economy as such, but represents a major—and hitherto much overlooked—segment of the labor force whose functions revolve around the maintenance of the material and social fabric of life in those areas.
Comparison of methadone and slow-release morphine maintenance in pregnant addicts.

AIMS To investigate whether the neonatal abstinence syndrome (NAS) is different in children born to women maintained on slow-release morphine, compared with those maintained on methadone, and to compare additional drug consumption in these groups of women. DESIGN, SETTING AND PARTICIPANTS An open, randomized trial was conducted in an established clinic. Forty-eight pregnant women who presented to the clinic as opiate or polysubstance abusers were enrolled and maintained on either methadone (24 women) or slow-release morphine (24 women) up to and following delivery. The programme included psychosocial therapy and support for their opiate-addicted partners. MEASUREMENTS Standard urinalysis methods were used to measure consumption of cocaine and benzodiazepines during pregnancy. Injection sites were monitored to indicate additional opiate use. NAS was measured according to Finnegan score and the amount of phenobarbiturates prescribed to alleviate the symptoms. FINDINGS No difference was found in the number of days that NAS was experienced by neonates born to methadone or morphine maintained mothers (mean = 16 and 21 days, respectively). All children were born healthy and no serious complications arose. Fewer benzodiazepines (p < 0.05) and fewer additional opiates (p < 0.05) were consumed by the morphine-maintained women compared with those who took methadone, but no difference was seen in cocaine consumption. Nicotine consumption was reduced significantly in both groups during pregnancy (p < 0.02). CONCLUSIONS Both methadone and morphine are suitable maintenance agents for pregnant opiate addicts. Maintenance agents that result in a less prolonged NAS should be studied in further trials.
Analysing the Determinants of Poverty Severity among Rural Farmers in Nigeria: A Censored Regression Model Approach

This study applied censored regression model approach to analyse the determinants of poverty severity among rural farmers in Nigeria using data from randomly sampled 233 rural farmers in Benue State. The study showed that 87.63% variation in poverty severity was explained by variations in the specified explanatory variables. Furthermore, at 5% level of significance, the critical determinants of poverty severity among the respondents were economic efficiency, household income, dependency ratio, ratio of food expenditure to total household expenditure, farm size, access to credit, household production enterprise structure, extent of household production diversification, extent of production commercialization, expenditure on education, access to agricultural extension services, membership of cooperative societies or other farmers’ associations, market access, total value of household assets, household size and formal education. Measures that promote both household enterprise diversification and agricultural production commercialization are highly desirable. Measures should be put in place to encourage the formation of effective farmers’ cooperatives and other farmers’ organizations for the purpose of knowledge transfer, input and output marketing and distribution, savings mobilization, and farm credit sourcing and supply.
Exchange Rate Behaviour after Recent Float: The Experience of Pakistan

The paper analyses different models to check the behaviour of exchange rate after the recent floating period in July 2000. It is found that the gap between the nominal and real exchange rate has widened after 9/11. Changes in the nominal exchange rate and real exchange rate are highly correlated and relative prices are not significantly correlated with the nominal exchange rate. Moreover, the exchange rate did not capture frequent changes in relative prices, which implies that PPP does not hold for the recent floating period. Real exchange rate always overshoots in response to exogenous shocks and then adjusts back to restore the equilibrium, although the adjustment process varies by country. The real exchange rate is not completely a random walk model and the movements are also explained by other fundamentals. It is safer to keep reserves in dollar and yen than in any other currency.
Limit Order Trading

The authors analyze the rationale for limit order trading. Use of limit orders involves two risks: (1) an adverse information event can trigger an undesirable execution, and (2) favorable news can result in a desirable execution not being obtained. On the other hand, a paucity of limit orders can result in accentuated short-term price fluctuations that compensate a limit order trader. The authors' empirical tests suggest that trading via limit orders dominates trading via market orders for market participants with relatively well-balanced portfolios, and that placing a network of buy and sell limit orders as a pure trading strategy is profitable. Copyright 1996 by American Finance Association.
Trade liberalisation and growth: a threshold exploration

Openness and trade liberalisation variables are consistently estimated to have significant positive coefficients in panel growth regressions. Many arguments have been advanced as to why and how more open or liberalised economies might grow faster, but the specific channels this process uses have begun to be investigated only recently. We continue these efforts by including a variable identifying the date of trade liberalisation in a system of equations that captures the determinants of growth in per capita income. Four ‘channels’ are considered: capital formation, the share of government, the economy's openness to trade and its price distortions. We include the liberalisation variable in the equation explaining each channel, and allow for thresholds on its coefficient depending on the ‘years since liberalisation’. These estimated coefficients can also differ by region. In this way, we can identify the channels through which trade liberalisation affects growth and uncover the timing of the adjustments involved.
Fraudulent Financial Reporting: Consideration of Industry Traits and Corporate Governance Mechanisms

This paper provides insight into financial statement fraud instances investigated during the late 1980s through the 1990s within three volatile industries—technology, health care, and financial services—and highlights important corporate governance differences between fraud companies and no‐fraud benchmarks on an industry‐by‐industry basis. The fraud techniques used vary substantially across industries, with revenue frauds most common in technology companies and asset frauds and misappropriations most common in financial‐services firms. For each of these three industries, the sample fraud companies have very weak governance mechanisms relative to no‐fraud industry benchmarks. Consistent with prior research, the fraud companies in the technology and financial‐services industries have fewer audit committees, while fraud companies in all three industries have less independent audit committees and less independent boards. In addition, this study provides initial evidence that the fraud companies in the techno.
CT angiography as a confirmatory test in diagnosis of brain death: comparison between three scoring systems.

PURPOSE Computed tomography (CT) angiography emerges as a viable alternative technique for confirmation of brain death. However, evaluation criteria are not well established for demonstration of cerebral circulatory arrest. This retrospective study aimed to evaluate CT angiography scoring systems in diagnosis of brain death, review the literature, and compare interobserver agreement between different scales for the diagnosis of brain death. METHODS CT angiography examinations of 25 patients with a clinical diagnosis of brain death were reevaluated according to 10-, 7-, and 4-point scales. Exams were performed with a 64-slice CT scanner including unenhanced, arterial (20 s) and venous phase (60 s) scans. Subtraction images of both phases were obtained. Interobserver agreement was evaluated for the assessment of vessel opacification and diagnosis of brain death. RESULTS According to 10-, 7-, and 4-point scales; 13, 16, and 22 of 25 patients had full score, respectively. Using the clinical exam as the reference standard, sensitivities obtained for 10-, 7-, and 4-point scales were 52%, 64%, and 88%, respectively. Percent agreement between readers was 100% for 10- and 7-point scales and 88% for 4-point scale. Percent agreement for opacification of scale vessels was equally high for all three scales (93.6%, 93.7%, 91% for 10-, 7-, and 4-point scales, respectively). CONCLUSION The 4-point scale appears to be more sensitive than the 10- and 7-point scales in CT angiography evaluation for brain death. Interobserver agreement is high for all three scales when subtraction images are used.