Miracle-dz/UniFAR-FTUs huggingface dataset:
Why do people fare evade? A global shift in fare evasion research

ABSTRACT Fare evasion is a significant concern for most transit authorities. The traditional approach to fare compliance has focussed on modifying the physical control of ticketing or ticket inspection rates. Yet recently the perspective on fare evasion has begun to shift toward profiling the fare evader or understanding the customer motivations to fare evade. This paper uses a literature review method to document the characteristics of these three perspectives on fare evasion: the conventional transit system perspective, the customer profiling perspective and the customer motivations perspective. We find that the conventional transit system perspective, although straightforward to measure and control, has its limits particularly in “open” transit systems. The customer profiling perspective attempts to identify, based on demographics, which customers are more likely to fare evade. However this perspective has little use beyond profiling and is ethically questionable. The customer motivations perspective provides a richer understanding of how customers define fare evasion and what attitudes, social norms and circumstances motivates them to fare evade. Considering that between 20% and 40% of a city’s residents admit to fare evading at some point, understanding these complex motivations can help improve revenue compliance at a time when most governments heavily subsidise their transit systems.
The culture of neural stem cells

A stem cell has three important features. Firstly, the ability of self‐renewal: making identical copies of itself. Secondly, multipotency, generating all the major cell lineages of the host tissue (in the case of embryonic stem cells—pluripotency). Thirdly, the ability to generate/regenerate tissues. Thus, the study of stem cells will help unravel the complexity of tissue development and organisation, and will also have important clinical applications. Neural stem cells (NSCs) are present during embryonic development and in certain regions of the adult central nervous system (CNS). Mobilizing adult NSCs to promote repair of injured or diseased CNS is a promising approach. Since NSCs may give rise to brain tumor, they represent in vitro models for anti‐cancer drug screening. To facilitate the use of NSCs in clinical scenarios, we need to explore the biology of these cells in greater details. One clear goal is to be able to definitively identify and purify NSCs. The neurosphere‐forming assay is robust and reflects the behavior of NSCs. Clonal analysis where single cells give rise to neurospheres need to be used to follow the self‐renewal and multipotency characteristics of NSCs. Neurosphere formation in combination with other markers of NSC behavior such as active Notch signaling represents the state of the art to follow these cells. Many issues connected with NSC biology need to be explored to provide a platform for clinical applications. Important future directions that are highlighted in this review are; identification of markers for NSCs, the use of NSCs in high‐throughput screens and the modelling of the central nervous development. There is no doubt that the study of NSCs is crucial if we are to tackle the diseases of the CNS such as Parkinson's and Alzheimer's. J. Cell. Biochem. 106: 1–6, 2009. © 2008 Wiley‐Liss, Inc.
Gender Differences in Locus of Control Scores for Students with Learning Disabilities

The present investigation examined gender differences on locus of control scores for students with learning disabilities. Scores from two measures of locus of control, the adult version of the Nowicki-Strickland Internal-External Scale and the Intellectual Achievement Responsibility Questionnaire, were compared for 77 boys (M age = 16.3 yr., M IQ = 89.5) and 27 girls (M age = 16.4 yr. and M IQ = 91.2). As groups were of unequal sizes, differences between scores were assessed by an analysis of unweighted means, creating a single harmonic mean and homogeneous subsets for all tests. Significant differences were found by gender on the Nowicki-Strickland inventory. On all assessments girls' means were more external than boys'. These results are discussed in light of recent findings concerning gender and positive adult outcomes for learners with learning disabilities and in relation to gender stereotyping and discrimination.
Effective Practices in STEM Integration: Describing Teacher Perceptions and Instructional Method Use.

Career and Technical Education (CTE), including agricultural education, has been suggested as a platform for delivering Science, Technology, Education, and Mathematics (STEM) content in secondary classrooms (Stone, 2011). The purpose of this descriptive study was to describe agriculture teachers’ perceptions and confidence levels for integrating the four STEM disciplines in agricultural education courses, along with perceptions and use of instructional methods for STEM integration. A stratified random sample (n =280) was drawn from agriculture teachers in three states (N =1,049), one state representing each of the American Association for Agricultural Education regions. Overall, teachers perceived each of the four components of STEM integration as important. Teachers had high levels of confidence in integrating science and mathematics, and reported lower confidence levels for technology and engineering. Although teachers reported spending most of their teaching time in lecture (M = 23.46; SD = 15.34) and ranked lecture first in overall confidence, lecture ranked seventh out of ten in effectiveness for student learning. Differences existed between gender and confidence integrating engineering, and perceptions of instructional method effectiveness. Results of this study suggest stakeholder examination of instructional methods which are most effective at integrating STEM concepts, and investigate how to increase teacher confidence with effective instructional methods for STEM concepts.
Smart wireless autonomous microsystems (SWAMs) for sensor actuator networks

Today a lot of different sensors and actuators are available which have an analog or digital, a standardized or not standardized interface. Many applications needs to measure sensor values, to control actuators and to interact between several sensors/actuators and other systems. Thus an intrinsic goal exists that the sensors and actuators can autonomously communicate with each other. A lot of applications are not suitable for wired communication. Hence there is an additional goal to realize the communication wireless. These goals lead to the challenge to implement smart, wireless, autonomous microsystems (SWAMs). Such a microsystem may capture the data of several sensors and control actuators. It will be intelligent and can communicate with a great number of other systems. Because the communication is wireless it is necessary that the SWAM is power aware to achieve a long lifetime. With SWAMs it is possible to build sensor actuator networks in the area of medical technology, environmental technology, process technology etc. This paper gives a survey about the requirements for the architecture of SWAMs. Then it will be pointed out, which feasibilities exist to realize such architectures. Finally the results from the implementation of such a microsystem will be presented and at the end of the paper novel applications will be showed.
trans-Complementation of yellow fever virus NS1 reveals a role in early RNA replication

Mutational analysis of the nonstructural protein 1 (NS1) of yellow fever virus (YF) has implicated it in viral RNA replication. To further explore this observation, we sought a method for uncoupling NS1 function from NS1 expression and processing as part of the large YF polyprotein. Here we describe a strategy for providing NS1 in trans, utilizing a noncytopathic Sindbis virus vector. Replication of a defective YF genome containing a large in-frame deletion of NS1 was dependent on functional expression of NS1. Recovered mutant virus was shown to contain the deletion and was neutralized by YF-specific antiserum. Complemented mutant virus increased in titer with kinetics similar to those of parental YF 17D but peaked at lower titers. trans-complementation has allowed us to derive high-titer, helper-free stocks of YF defective in NS1 with which to further characterize the role of this gene product in RNA replication. The first cycles of RNA replication were analyzed by using a sensitive strand-specific RNase protection assay. We document these events for mutant and wild-type viruses in the presence or absence of complementation. These data strongly suggest a role for NS1 prior to or at initial minus-strand synthesis.
Alterations in circulating angiogenic and anti‐angiogenic factors in type 2 diabetic patients with neuropathy

Diabetic peripheral neuropathy (DPN) is one of the most common diabetic chronic complications. There is an increased attention directed towards the role of angiogenic factors including vascular endothelial growth factor (VEGF) and anti‐angiogenic factors including soluble endoglin (sEng) as contributors to diabetic microvascular complications including neuropathy. The purposes of this study were to determine the role of these angiogenesis regulators in the prognosis of DPN.
Clinical Potential of MicroRNAs in Pancreatic Ductal Adenocarcinoma

Objectives: Aggressive invasion and early metastases are characteristic features of pancreatic ductal adenocarcinoma (PDAC). More than 90% of patients have surgically nonresectable disease at presentation. Despite increasing knowledge of the genetics of this complex disease, systemic therapies, particularly gemcitabine, have modest clinical benefit and marginal survival advantage. MicroRNAs have been shown to have a role in oncogenesis, invasion, and metastases via epigenetic posttranscriptional gene regulation. Our objective was to discuss the clinical impact of microRNAs within PDAC. Methods: This review details the understanding of microRNAs to date and explores the clinical utility of microRNAs in PDAC. Results: Recent studies have focused on the impact of microRNA expression in PDAC, many of which have shown the diagnostic, predictive, and prognostic utility of microRNA profiling in PDAC identifying numerous potential targets including miR-21, miR-196a, and miR-217. Conclusions: MicroRNA stability in body fluid and tissue samples makes this area one of the most promising for earlier detection of PDAC. Indeed, microRNAs may in the future serve as a long-awaited screening tool for PDAC. Furthermore, microRNA expression profiling in PDAC may be incorporated into modern treatment algorithms to enhance therapeutic management. Equally as exciting is the potential for novel therapeutics directed against these important disease mediators.
Benzo(a)pyrene:DNA adduct formation in normal human mammary epithelial cell cultures and the human mammary carcinoma T47D cell line.

The benzo(a)pyrene (BaP):DNA adducts formed in normal human mammary epithelial cell cultures and the human mammary carcinoma T47D cell line were analyzed by chromatography and acid hydrolysis of the BaP:deoxyribonucleoside adducts to BaP:purine adducts and BaP:tetraols. Human mammary epithelial cell cultures and human mammary carcinoma T47D cells were exposed to [3H]BaP for 24 h, and the levels of binding were 81 and 182 pmol BaP/mg DNA in normal and T47D cultures, respectively. Analysis of BaP:deoxyribonucleoside adducts resolved by immobilized boronate chromatography and reversephase high-performance liquid chromatography demonstrated the presence of three BaP:deoxyribonucleoside adducts in both cells: M2, MS1, and MS2 in a ratio of 1.6:1:14. Two adducts (MS1 and MS2) bound to the immobilized boronate column indicating the presence of cis-vicinal hydroxyl groups, a configuration which would result from reaction of 7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydroBaP (anti-BaPDE) with DNA. MS2 was identified as (+)-anti-BaPDE:deoxyguanosine (dGuo) for it cochromatographed with a [14C]-(+)-anti-BaPDE:dGuo marker, the BaP:purine hydrolysis product of MS2 cochromatographed with [14C]-(+)-anti-BaPDE:guanine, and the tetraol hydrolysis products cochromatographed with (+/-)-anti-BaPDE:tetraols. MS1 was identified as (-)-anti-BaPDE:dGuo for MS1 eluted in the same relative position as a (-)-anti-BaPDE:dGuo marker, the BaP:purine hydrolysis product of MS1 cochromatographed with [14C]-(+)-anti-BaPDE:guanine, and the tetraol hydrolysis products cochromatographed with (+/-)-anti-BaPDE:tetraols. Thus, both adducts that bound to the immobilized boronate column were formed from (+/-)-anti-BaPDE. One major adduct that did not contain cis-vicinal hydroxy groups, M2, was detected in both cell types. M2 was formed from (+/-)-7 beta, 8 alpha-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydroBaP (syn-BaPDE) as M2 eluted in the same relative position as a syn-BaPDE:dGuo adduct marker and the tetraol hydrolysis products of M2 cochromatographed with tetraols formed from (+/-)-syn-BaPDE. The isolation of the individual BaP:DNA adducts followed by acid hydrolysis allowed the identification of the BaP:DNA adducts formed in human mammary cell cultures and demonstrated the presence of (-)-anti-BaPDE:dGuo. Thus, this work provides the first evidence, other than cochromatography, that (-)-anti-BaPDE is formed in cell systems and reacts with DNA in cells to form (-)-anti-BaPDE:dGuo. (ABSTRACT TRUNCATED AT 400 WORDS)
Information management in Iranian Maternal Mortality Surveillance System

Background Maternal mortality is preventable by proper information management and is the main target of the Maternal Mortality Surveillance System (MMSS). Aim This study aimed to determine the status of information management in the Iranian Maternal Mortality Surveillance System (IMMSS). Methods The population of this descriptive and analytical study, which was conducted in 2016, included 96 administrative staff of health and treatment deputies of universities of medical sciences and the Ministry of Health in Iran. Data were gathered by a five-part questionnaire with confirmed validity and reliability. A total of 76 questionnaires were completed, and data were analyzed using SPSS software, version 19, by descriptive and inferential statistics. The relationship between variables “organizational unit” and the four studied axes was studied using Kendall’s correlation coefficient test. Results The status of information management in IMMSS was desirable. Data gathering and storage axis and data processing and compilation axis achieved the highest (2.7±0.46) and the lowest (2.4±0.49) mean scores, respectively. The data-gathering method, control of a sample of women deaths in reproductive age in the universities of medical sciences, use of international classification of disease, and use of this system information by management teams to set resources allocation achieved the lowest mean scores in studied axes. Treatment deputy staff had a more positive attitude toward the status of information management of IMMSS than the health deputy staff (p=0.004). Conclusion Although the status of information management in IMMSS was desirable, it could be improved by modification of the data-gathering method; creating communication links between different data resources; a periodic sample control of women deaths in reproductive age in the universities of medical sciences; and implementing ICD-MM and integration of its rules on a unified system of death.
Bacterial inactivation/sterilization by argon plasma treatment on contaminated titanium implant surfaces:In vitro study

Background Surface treatment by argon plasma is widely used as the last step of the manufacturing process of titanium implant fixtures before their sterilization by gamma rays. The possibility of using such a technology in the daily clinical practice is particularly fascinating. The aim of the present study was to assess the effects of the argon plasma treatment on different titanium implant surfaces previously exposed In vitro to bacterial contamination. Material and Methods Sterile c.p. titanium implant discs with turned (T, Sa: 0.8 µm ), sandblasted/acid-etched (SAE, Sa: 1.3 µm) and titanium plasma sprayed (TPS, Sa: 3.0µm) surface were used in this study. A strain of Aggregatibacter actinomycetemcomitans ATCC3718 was grown at 37°C under anaerobic conditions for 24 h and then transferred on six discs for each of the three surface types. After 24 hours, a half of the contaminated discs (control group) were directly used to evaluate the colony forming units (CFUs). The other half of the contaminated discs (test group) were treated in an argon plasma chamber for 12 minutes at room temperature prior to be analyzed for CFU counting. All assays were performed using triplicate samples of each material in 3 different experiments. Results When the CFU counting was carried out on control discs, a total of 1.50x106±1.4x105, 1.55x106±7.07x104 and 3.15x106±2.12x105 CFU was respectively assessed for T, SAE and TPS discs, without statistically significant differences among the three surfaces. On the contrary, any trace of bacterial contamination was assessed for titanium discs treated in the argon plasma chamber prior to be analyzed, irrespectively to the implant surface tested. Conclusions Within the limit of this study, reported data suggested that the argon plasma technology could be efficiently used to decontaminate/sterilize previously infected titanium implant surfaces. Key words:Argon plasma, titanium implant surface, Aggregatibacter actinomycetemcomitans.
Characteristics of a BHK cell variant defective in the cell‐substratum contact process

In this paper we document the phenotypic characteristics of a novel BHK cell adhesion variant designated FN‐2. Unlike parental cells, FN‐2 cells did not attach to fibronectin (pFN)‐coated dishes, even after 4‐hr incubations on dishes treated with 100 μg/ml of pFN. Mixing experiments with the variant and parental cells revealed that the parental cells attached normally in the presence of a ninefold excess of variant cells and the variant cells failed to attach in the presence of a ninefold excess of parental cells. Therefore, the defect in FN‐2 cells could not be explained by secretion of a factor inhibiting attachment or lack of secretion of a factor required for attachment. Also, the inability of FN‐2 cells to attach to pFN‐coated dishes could not be explained by an absence of cell pFN receptors since the variant cells bound normal numbers of small (ca. 0.8 μm) pFN‐coated latex beads, although they phagocytosed the beads poorly compared to parental cells. Also, the variant cells were not able to bind large (5.7 or 16.8 μm) pFN‐coated beads. When tested on dishes coated with ligands that, unlike fibronectin, have a high affinity for cell surface receptors, e.g., lectins and anti‐BHK antibodies, FN‐2 cells were observed to attach at a rate similar to that of parental cells but spread much more slowly. The phenotypic characteristics of FN‐2 cells suggest that they are deficient in what previously has been called the “cell contact” process in cell adhesion. It is proposed that the cell contact process is the initial formation by an individual cell of a sufficient number of cell‐substratum bonds to resist the shear forces operationally used to define “attachment,” and that more cell‐substratum bonds are necessary for cell attachment to large substrata (dishes or large beads) than for attachment to small substrata (small beads). The molecular defect in FN‐2 cells was studied by electroblotting analysis. A high molecular weight (ca. 370 kd) glycoprotein detected by blotting with anti‐BHK antibodies and ConA that was present in parental cell membranes was reduced or absent in the variant cells.
A comparison between intravenous lidocaine and ketamine on acute and chronic pain after open nephrectomy: A prospective, double-blind, randomized, placebo-controlled study

Background: Recently, there has been increasing interest in the use of analgesic adjuncts such as intravenous (IV) ketamine and lidocaine. Objectives: To compare the effects of perioperative IV lidocaine and ketamine on morphine requirements, pain scores, quality of recovery, and chronic pain after open nephrectomy. Study Design: A prospective, randomized, placebo-controlled, double-blind trial. Settings: The study was conducted in Charles Nicolle University Hospital of Tunis. Methods: Sixty patients were randomly allocated to receive IV lidocaine: bolus of 1.5 mg/kg at the induction of anesthesia followed by infusion of 1 mg/kg/h intraoperatively and for 24 h postoperatively or ketamine: bolus of 0.15 mg/kg followed by infusion of 0.1 mg/kg/h intraoperatively and for 24 h postoperatively or an equal volume of saline (control group [CG]). Measurements: Morphine consumption, visual analog scale pain scores, time to the first passage of flatus and feces, postoperative nausea and vomiting (PONV), 6-min walk distance (6MWD) at discharge, and the incidence of chronic neuropathic pain using the “Neuropathic Pain Questionnaire” at 3 months. Results: Ketamine and lidocaine reduced significantly morphine consumption (by about 33% and 42%, respectively) and pain scores compared with the CG (P < 0.001). Lidocaine and ketamine also significantly improved bowel function in comparison to the CG (P < 0.001). Ketamine failed to reduce the incidence of PONV. The 6 MWD increased significantly from a mean ± standard deviation of 27 ± 16.2 m in the CG to 82.3 ± 28 m in the lidocaine group (P < 0.001). Lidocaine, but not ketamine, reduced significantly the development of neuropathic pain at 3 months (P < 0.05). Conclusion: Ketamine and lidocaine are safe and effective adjuvants to decrease opioid consumption and control early pain. We also suggest that lidocaine infusion serves as an interesting alternative to improve the functional walking capacity and prevent chronic neuropathic pain at 3 months after open nephrectomy.
Dissecting Announcement Returns

We develop a model with informationally heterogeneous investors to explain return predictability on and after earnings announcements. We find evidence for the model’s key predictions: (1) Announcement returns are on average positive even though earnings surprises are mean-zero; (2) Firms with more uncertain fundamentals earn higher announcement returns; (3) Announcement returns predict fundamentals and price drifts but (4) most of the predictive power comes from announcement returns unrelated to earnings surprises; (5) A factor based on announcement returns unrelated to earnings surprises is highly profitable and subsumes momentum. Our results provide strong evidence that investors disagree about the information conveyed by announcements.
Dissociative Adsorption of Hydrogen and Oxygen on Palladium Clusters:  A Comparison with the (111) Infinite Surface.

We report a density-functional study of some properties of the dissociative interaction of hydrogen and oxygen molecules on small palladium clusters (n = 5, 7, and 10). The calculated physisorption and chemisorption energies are compared with those of the infinite (111) palladium surface. First, adsorption of atomic hydrogen and oxygen is investigated on the Pd5, Pd7, and Pd10 clusters. Second, the interaction between H2 (O2) and the small Pd5 cluster is examined and compared to the process occurring on an infinite (111) surface. Finally, the simultaneous adsorption of two hydrogen (oxygen) atoms is analyzed in detail. As shown in a previous work, the binding energy of the first hydrogen (oxygen) atom does not depend significantly on the cluster size, and small two-layer clusters (n ≤ 10) can be used to determine with accuracy the interaction of atomic adsorbates with an infinite (111) palladium surface. In this study, we show that the dissociative chemisorption of H2 and more especially of O2 on a small palladium cluster may lead to erroneous binding energy: the cluster's size may prevent an accurate description of the adsorbate-adsorbate interaction as a function of their distance. It is demonstrated that a good choice of both the size and the shape of the cluster is preponderant for a good description of the dissociative adsorption of H2 and O2 on an infinite (111) surface.