Miracle-dz/UniFAR-FTUs huggingface dataset:
Prostate Cancer Safety and Antitumour Activity of ODM-201 ( BAY-1841788 ) in Castration-resistant , CYP 17 Inhibitor-naïve Prostate Cancer : Results from Extended Follow-up of the ARADES Trial

a Institut Gustave Roussy, University of Paris Sud, Villejuif, France; Comprehensive Cancer Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland; Kuopio University Hospital, Kuopio, Finland; Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; e Tampere University Hospital, Tampere, Finland; Orion Corporation, Orion Pharma, Espoo, Finland E U R O P E A N U R O L O G Y F O C U S 3 ( 2 0 17 ) 6 0 6 – 6 1 4
Evidence on credit constraints and university attendance.∗

The effects of credit constraints on university participation are investigated. Students most likely to face credit constraints have the same or higher probability of attending university as all other students, given their high school achievement. A novel approach to handle potential bias arising from unobservable heterogeneity is proposed and implemented, providing estimated unobservables based on post secondary plans reported during ninth grade. These estimated unobservables are important in explaining university attendance but results regarding the effects of credit constraints are robust to their inclusion in models estimated. Our new estimated unobservables approach is consistent with a related Copula estimation approach. JEL Classification: I21, I22, I28
Green and chemical method of activated silica as adsorbent for arsenic removal by zinc oxide nanoparticle modification

Presently the progress of green chemistry in the synthesis of Zinc oxide nanoparticle entrenched on activated silica (ZnO-NPs-AS) using environmentally benign leaf extract of Azadirachta indica, Zinc acetate, sodium hydroxide and activated silica with diverse roles as adsorbent has fascinated a great attention. In this study, report on the exploit of activated silica (AS) as a proxy for adsorption using Chemical method. The present exploration describes the synthesis and characterization of ZnO-NPs-AS and AS prepared by green and chemical technique. Adsorption parameters for the Langmuir, Freundlich, Tempkin and BET isotherms were dogged and the equilibrium data were best described by Langmuir, Tempkin and BET model and fits quite well with the experimental data with good correlation coefficient of 0.974, 0.9430 and 0.9995 for ZnO-NPs-AS than AS. The results of intraparticle diffusion model suggested that intraparticle diffusion was not the rate controlling process. From the values it is accomplished that the maximum adsorption corresponds to a saturated monolayer of As3+ molecules on the adsorbent surface of ZnO-NPs-AS. The data were analysed using kinetics models analogous to Pseudo first and second order. All the findings presented in this study suggested following Pseudo second order equation for the adsorption of As3+ on to ZnoNPs-AS. The synthesized ZnO-NPs-AS and AS was characterized for BET surface area, pore size and specific pore volume. The sharp peaks by X-Ray Diffraction Analysis (XRD) pattern show the crystallinity and purity of the sample. Formation of ZNO-NPs-AS and AS was confirmed by scanning electron microscopy (SEM). Particle Size Analyser (PSA) shows the fashioned ZNONPs-AS and AS ranged in dimension of about 100 and 1000 nm. The results confirmed that aqueous leaf extract of Azadirachta indica is a suitable green template to prepare ZNO-NPs-AS for adsorption. Though chemical and green methods are trendier for adsorption process, the biogenic green fabrication of ZnO-NPs-AS is a better choice of adsorption due to ecofriendliness large surface area and high adsorption of 99% of As3+.
Effect of plant density on yield and physiological characteristics of six canola cultivars

An experiment was performed in the Seed and Plant Improvement Institute, Karaj, Iran to study the influence of plant densities on physiological traits of six canola cultivars. Treatment conditions included three different plant densities (40, 60, and 80 plants m-2) for triplicates of six canola cultivars, namely, Ahamadi, Opera, Okapi, L72, Karaj1, and Sw102. Results indicated that L72 cultivar exhibited the highest yield at the lowest plant density (40 plants m-2). For all cultivars, both plant densities of 60 and 80 plants m-2 resulted in lower relative water content than 40 plants m-2. Proline and carbohydrate content significantly increased with increasing plant densities. The highest proline content was obtained from L72 under the highest plant density, whereas the lowest was also detected in this cultivar at the lowest plant density. All cultivars grown at the lowest density showed higher amounts of photosynthetic pigments chlorophylls a and b than those at the highest density. Glucosinolate increased with increasing plant densities, with L72 yielding the highest quantity when grown at the highest density. In conclusion, a density of 40 plants m-2 is recommended for growing L72 in this region.
THE ANALYSIS OF APPLICATION OF FAIR VALUE AND HISTORICAL COST APPROACHES IN THE VALUATION OF BIOLOGICAL ASSETS IN THE AGRICULTURAL COMPANIES

This study discusses the analysis of application of fair value and historical cost approaches used by agricultural companies in valuing their biological assets. The term of biological assets in this study refers to the biological assets possessed by agricultural companies specifically plantation companies. Due to IFRS convergence process done by IAI to adopt IAS 41, this study aims to provide initial evidence on the comparison of fair values approach and historical cost approach in valuing the biological assets. The comparison is intended to figure out the existence of significant differences in the value of assets, return on assets, revenue and earnings between two groups which uses two different valuation approaches. This study also aims to prove the existence of larger income smoothing propensity in the group of companies using fair values approach compared to those using historical cost approach. Eventually, the study tries to prove the influence of the fair value approach to earnings volatility which is indicated to be higher than the historical cost approach. Based on the result of statistical tests, it is concluded that there is no significant differences in the value and volatility of the assets, return on assets, revenue and earnings between the two groups. This finding implies that there is no significant influence of the application of fair value approach to the volatility of company’s earnings.
Deep Neural Networks for Biometric Identification Based on Non-Intrusive ECG Acquisitions

The electrocardiogram has gained traction as a biometric trait due to its outstanding combination of universality, permanence, and measurability, with a hidden nature that makes it harder to steal or counterfeit. The state-of-the-art mostly consists of pipeline algorithms, composed of separate stages of denoising, segmentation, feature extraction, and decision. However, Convolutional Neural Networks (CNNs), possess the tools to integrate all phases of processing, from acquisition to decision, in a single model. This integration replaces separate, step-by-step tuning with an holistic optimisation process, synergically adapting the model to attain the best performance possible. In this chapter, we introduce and explore the capabilities of convolutional neural networks for biometric identification using non-intrusive ECG signal acquisitions, and propose a CNN architecture for the complete integration of traditional pipeline stages in a single accurate and robust model. The method was evaluated on the highly complete and challenging UofTDB collection, and has shown promising results on identification tasks when compared with recent and successful state-of-the-art methods.
- 1-CHINESE MNCs IN LATIN AMERICA : CHARACTERISTICS AND COMPARISONS WITH INVESTMENTS IN DEVELOPED MARKETS

This paper analyses the characteristics of Chinese MNCs operating in Latin America vis-à-vis those found in previous studies of Chinese companies investing in developed countries. It does this by studying the fit of theoretical frameworks recently developed for Chinese firms, the support from the government, and the strength of their capabilities in relation to those of local competitors. The analysis is based on case studies with data collected through seven indepth interviews with senior managers of subsidiaries in Latin America and the president of a chamber of commerce. The results show that these companies seem to be following a pattern similar to that described by Mathews’ (2006) LLL, that the support from the government does not seem to play a role in their internationalisation process, and that they appear to have developed a set of capabilities strong enough to compete in the host market (in particular how to combine their strengths with those of local partners). There are also findings related to the reliance on ethnically-based social networks and on the chosen entry mode. The findings tend to indicate that Chinese companies are following a pattern in their internationalisation to Latin American emerging markets that seems to be a combination of conventional theories (including previous studies on emerging markets-based firms) with idiosyncratic elements.
SPRAY UNIFORMITY TESTING OF UNMANNED AERIAL SPRAYING SYSTEM FOR PRECISE AGROCHEMICAL APPLICATIONS

Agro-chemicals are being widely used in the world for enhancing agriculture production and productivity (Muhammad et al., 2006). However, the World Health Organization report around one million illness cased due to manual spraying of pesticides in the fields (Mogili and Deepak, 2018). It is estimated that annually worldwide about 3 million metric tons of pesticides are used to control the disease (Pimentel, 2009). These chemicals not only control weeds but also help to control insect pest attack that cause the reduction of crop yield and affect the crop quality as well (Li et al., 2009). For example, In Pakistan, the insect pests reported attacking rice crop and causing 20-25% losses to this important foreign exchange earning crop on recurrent basis (Jabbar et al., 1993). On an average, 37% reduction in rice yield has been estimated due to the insect pests (Savary et al., 2000). In developing countries, including Pakistan, agro-chemicals are being applied on crops to control pests and weeds by conventional spraying systems without considering substantial variation in plant population and canopies (Faical et al., 2017). Now a day’s real time monitoring of crop health is possible by using high spectral resolution which help us in real time spraying through chlorophyll content based on vegetation indices (Tahir et al., 2018). Excessive application for the regions without vegetation could result in over-use of the expensive agro-chemicals as well as environmental hazard. The drift and the leaching of the applied agrochemicals is a threat to the environment as well as underground water reserves. The conventional sprayers used by farmers also have health impacts as the operator is in proximity of the chemical. Such conventional landspraying machines have become inconvenient for spraying in crops like rice, cotton and sugarcane as well as orchards due to crop growth stages and poor efficiency (Baggio, 2005; Daberkow and McBride, 2003; McBratney et al., 2005; Saizhang and Zhong, 2002). About 40% of all the crops could be affected due to non-uniform spray or late spraying (Peshin et al., 2009). Moreover, the continuous increasing cost of the agrochemicals and an un-precedent dependence on these chemicals for the increased production leads to an economic threat while below-par application would restrict the crop yield. This leads to the conclusion to apply the plant protection products (PPP) with utmost efficiency in a calculated manner as per the field conditions to avoid Pak. J. Agri. Sci., Vol. 56(4), 897-903; 2019 ISSN (Print) 0552-9034, ISSN (Online) 2076-0906 DOI:10.21162/PAKJAS/19.8594 http://www.pakjas. com.pk
Production and Adoption Constraints of Improved Coffee Varieties in Jimma Zone, Southwest Ethiopia

The study was aimed to identify major coffee production problems that affected coffee farmers’ production and productivity. The study was conducted in four districts of Jimma zone namely Gera, Manna, Limu Kosa and Gomma. Multistage sampling technique was employed to select the population for the study which involved both purposive and random sampling techniques. Data was collected through structured questionnaire administered to sampled farmers from 285 coffee producing households. Both descriptive and inferential statistics were used to analyze the gathered and cleaned data. Kendall’s coefficient of concordance was used to rank the most important coffee production constraints. The study has identified three top constraints on coffee production. Low and fluctuating coffee price, coffee market information problem and lack of coffee seed and seedling varieties preferred were the major problems explored. Strengthening cooperatives and unions, sustainable supply of improved coffee seeds and seedlings, and sustainable coffee seed system are suggested to tackle coffee production problems.
HAEMATOLOGICAL INDICES OF THE Clarias gariepinus X Heterobranchus longifilis ( HYBRID CATFISH-Heteroclarias ) REARED AT DIFFERENT FEEDING LEVELS

Department of Fisheries and Aquatic Environmental Management, University of Uyo. Department of Fisheries and Aquatic Resources Management, Michael Okpara University of Agriculture, Umudike. E-mail: ofnex@yahoo.com, chukofor@gmail.com. Phone number: 08028381053 The haematological indices of hybrid catfish reared at different feeding levels of 100 fish per 0.25 m stocking density, was investigated for a period of twelve (12) months. The 100 fingerlings were stocked in three replicates and fed at 1%, 1.5% and 2% body weights. They were fed three times daily and the feed was adjusted monthly with increased weight gain. Water quality parameters (temperature, dissolved oxygen and pH) were monitored. There were no significant (p>0.05) differences in the values obtained for temperature and pH with the feeding levels while significant difference (p<0.05) occurred in the values for dissolved oxygen with the feeding levels, although this was within the range acceptable for fish culture. The heamatological results showed that there were no significant difference (p>0.05) in the values obtained for white blood cell, haematocrit, mean cell volume, mean cell haemoglobin and mean cell haemoglobin concentration. Red blood cell recorded highest value (2.85 ± 0.12) at 1.5% feeding level and lowest value (2.43 ± 0.04) at 1% feeding level. There was increase in haemoglobin concentration at 1.5% feeding level (13.07 ± 0.32) and a decrease at 1.0 % feeding level (11.33 ± 0.33). Positive correlation was observed among haemoglobin, haematocrit and mean corpuscular volume while negative correlation was discerned among mean cell haemoglobin and mean cell haemoglobin concentration.
Motivation and Setup 2 . 1 Motivation

The local power of many popular non-cointegration tests has recently been shown to depend on a certain nuisance parameter. Depending on the value of that parameter, different tests perform best. This paper suggests combination procedures with the aim of providing meta tests that maintain high power across the range of the nuisance parameter. The local power of the new meta tests is in general almost as high as that of the more powerful of the underlying tests. When the underlying tests have similar power, the meta tests are even more powerful than the best underlying test. At the same time, our new meta tests avoid the arbitrary decision which test to use if individual test results conflict. Moreover it avoids the size distortion inherent in separately applying multiple tests for cointegration to the same data set. We use the new tests to 286 investigate data sets from published cointegration studies. There, in one third of all cases individual tests give conflicting results whereas our meta tests provide an unambiguous test decision.
The role of mindfulness in coaching

In this article we explore the concept of mindfulness as a tool for helping both coaches and coachees. We argue that the coaching practice of the coach can be enhanced through using mindfulness as a preparation tool. We highlight research evidence on the impact of mindfulness in managing stress and contributing towards improved performance. We argue that coachees too can benefit when the coach shares these techniques with the coachee.
Compound heterozygous mutations in TTC 7 A cause familial multiple intestinal atresias and severe combined immunodeficiency

Familial multiple intestinal atresias is an autosomal recessive disease with or without combined immunodeficiency. In the last year, several reports have described mutations in the gene TTC7A as causal to the disease in different populations. However, exact correlation between different genotypes and various phenotypes are not clear. In this study, we report identification of novel compound heterozygous mutations in TTC7A gene in a Malay girl with familial multiple intestinal atresias and severe combined immunodeficiency (MIA-SCID) by whole exome sequencing. We found two mutations in TTC7A: one that destroyed a putative splicing acceptor at the junction of intron 17/exon 18 and one that introduced a stop codon that would truncate the last two amino acids of the encoded protein. Reviewing the recent reports on TTC7A mutations reveals correlation between the position and nature of the mutations with patient survival and clinical manifestations. Examination of public databases also suggests carrier status for healthy individuals, making a case for population screening on this gene, especially in populations with suspected frequent founder mutations.
POLITECNICO DI TORINO Repository ISTITUZIONALE A framework for computational fluid dynamic analyses of patient-specific stented coronary arteries from optical coherence tomography

The clinical challenge of percutaneous coronary interventions (PCI) is highly dependent on the recognition of the coronary anatomy of each individual. The classic imaging modality used for PCI is angiography, but advanced imaging techniques that are routinely performed during PCI, like optical coherence tomography (OCT), may provide detailed knowledge of the pre-intervention vessel anatomy as well as the post-procedural assessment of the specific stent-to-vessel interactions. Computational fluid dynamics (CFD) is an emerging investigational tool in the setting of optimization of PCI results. In this study, an OCT-based reconstruction method was developed for the execution of CFD simulations of patient-specific coronary artery models which include the actual geometry of the implanted stent. The method was applied to a rigid phantom resembling a stented segment of the left anterior descending coronary artery. The segmentation algorithm was validated against manual segmentation. A strong correlation was found between automatic and manual segmentation of lumen in terms of area values. Similarity indices resulted > 96% for the lumen segmentation and > 77% for the stent strut segmentation. The 3D reconstruction achieved for the stented phantom was also assessed with the geometry provided by X-ray computed micro tomography scan, used as ground truth, and showed the incidence of distortion from catheter-based imaging techniques. The 3D reconstruction was successfully used to perform CFD analyses, demonstrating a great potential for patient-specific investigations. In conclusion, OCT may represent a reliable source for patient-specific CFD analyses which may be optimized using dedicated automatic segmentation algorithms. © 2017 The Authors. Published by Elsevier Ltd on behalf of IPEM. This is an open access article under the CC BY-NC-ND license. ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
Investigation on Improvement of Surface Roughness Using Rotary Ultrasonic Assisted Machining Technique for Hardened Steel Material

Several challenges are faced by manufacturers producing best surface finish especially for the mould and die applications. In general, most of the mould and die material are made from hardened steel (~40-60 HRc). The high strength of these materials reduced the capability of the conventional machining technique. Poor machined surface and high tool wear rate are among the problems associated with the conventional machining of this material. To overcome these problems, this paper proposed a hybrid machining process by adding an ultrasonic transducer to the normal tooling system namely ultrasonic assisted machining (UAM). Experimental work consisted of a comparison between ultrasonic assisted machining and conventional machining for different parameters namely cutting speed, feed rate and machining depth in order to validate the effectiveness of the proposed technique in improving the surface roughness value for machining hardened AISI D2 material. 2 level factorial design with 3 factors was employed as the technique of design of experiment (DOE). The machining
Abstract THERMOACOUSTIC VELOCITY COUPLING IN A SWIRL-STABILIZED GAS TURBINE MODEL COMBUSTOR

THERMO-ACOUSTIC VELOCITY COUPLING IN A SWIRL-STABILIZED GAS TURBINE MODEL COMBUSTOR Vincent R. Caux-Brisebois Masters of Applied Science Graduate Department of Aerospace Engineering University of Toronto 2013 The research presented herein describes the coupling of acoustic and heat release uctuations in a perfectly-premixed swirl-stabilized combustor by analysis of simultaneous high-repetition-rate laser diagnostics data. Nine cases are studied, varying the thermal power and the equivalence ratio. Proper orthogonal decomposition (POD) of the velocity data shows that cases with higher amplitude thermoacoustic oscillations have ow elds containing helical vortex cores (HVC); these cases are further analysed to determine the driving mechanisms of the oscillations. Flow and ame statistics are compiled as a function of both the phase in the thermoacoustic cycle and a phase representing the azimuthal position of the HVC relative to the measurement plane. These data are used to spatially map the thermoacoustic energy transfer eld, as described by the Rayleigh integral. It is found that periodic deformations of the HVC cause large-scale ame motions, resulting in regions of positive and negative energy transfer.
Redacted for Privacy

This thesis examines how two grass seed industries respond to changes in the production environment. Two sets of factors are necessary to understand what adjustments would be made. First, it is necessary to know the nature of the markets and whether market power is being exerted. Second we need to know the relative demand and supply elasticities for the products.