Miracle-dz/UniFAR-FTUs huggingface dataset:
Retrospective Evaluation of Healing of Periapical Lesions after Unintentional Extrusion of Mineral Trioxide Aggregate

Background During the apexification procedure for teeth with open apices, mineral trioxide aggregate (MTA) may be unintentionally extruded. The aim of the present study was the retrospective evaluation of the healing of periapical lesions in permanent incisor teeth with open apices after the unintentional extrusion of MTA. Methods The clinical and radiographic records of 55 maxillary permanent central teeth treated by MTA apexification were evaluated. Filled teeth with unintentionally extruded MTA were selected as group 1 (n = 21), whereas the teeth with no MTA extrusion were selected as group 2 (n = 34). For each tooth, the clinical and radiographic records from a 3-year follow-up were investigated. Results Complete healing (CH) was observed in 19 teeth (90.4%) in group 1, whereas the same type of healing was observed in all 34 teeth (100%) in group 2 (p>0.05). At the 6-month follow-up appointment, 25 teeth (73.5%) showed CH in group 2, whereas 15 teeth (71.4%) showed CH at the 1-year follow-up in group 1 (p<0.001). At the end of the 3-year follow-up period, the amount of MTA extrusion was reduced in 17 teeth (85%) (p<0.05), whereas it was almost absent in 2 teeth (10%). Conclusions The unintentional extrusion of MTA does not prevent the healing of periapical lesions, but may be a delaying factor for periapical healing.
Quantitative detection of soluble adhesion molecules in sera of melanoma patients correlates with clinical stage.

BACKGROUND Adhesion is crucial in the metastatic process of malignant tumours. Recently, the expression of certain selectins on intratumoral vessels has been shown to be associated with the clinical outcome of melanoma patients. OBJECTIVES AND METHODS For the first time, this study examines the serum concentrations of circulating soluble vascular cellular adhesion molecule 1 (CD 106), endothelial leucocyte adhesion molecule (CD62E), sP-selectin (CD62P) and sCD44v5 in comparison to soluble intercellular adhesion molecule 1 (sICAM-1, CD54) in a series of 34 melanoma patients at different clinical stages and 11 normal donors using ELISA: RESULTS sICAM-1 and sP-selectin levels were statistically elevated in all subgroups of melanoma patients compared to controls (p < 0.01). Circulating ICAM-1 as well as sP-selectin might be valuable additional serological tumour markers which correspond to tumour load and correlate with progression of malignant melanoma. CONCLUSION Measurement of sICAM-1 and sP-selectin serum levels might therefore provide a sensitive tool for monitoring the clinical course of melanoma.
Stackelberg Interdependent Security Game in Distributed and Hierarchical Cyber-Physical Systems

With the integration of physical plant and network, cyber-physical systems (CPSs) are increasingly vulnerable due to their distributed and hierarchical framework. Stackelberg interdependent security game (SISG) is proposed for characterizing the interdependent security in CPSs, that is, the interactions between individual CPSs, which are selfish but nonmalicious with the payoff function being formulated from a cross-layer perspective. The pure-strategy equilibria for two-player symmetric SISG are firstly analyzed with the strategy gap between individual and social optimum being characterized, which is known as negative externalities. Then, the results are further extended to the asymmetric and -player SISG. At last, a numerical case of practical experiment platform is analyzed for determining the comprehensively optimal security configuration for administrator.
Super High‐Flux Continuous Venovenous Hemodialysis Using Regional Citrate Anticoagulation: Long‐Term Stability of Middle Molecule Clearance

Continuous renal replacement therapy is a standard treatment in critically ill patients with acute kidney injury. All CRRT techniques provide a high low‐molecular weight clearance but even with hemofiltration, clearance of middle molecules is low. We investigated whether a new super high‐flux hemofilter provides effective and sustained middle molecule clearance during citrate‐anticoagulated continuous venovenous hemodialysis for up to 72 h. We included 14 critically ill patients with AKI‐KDIGO‐III in a prospective observational trial. We measured/calculated blood and urine concentrations, clearances and sieving coefficients of eight molecules with molecular weights from 60 to 66 kDa, hemodynamic parameters and SAPS‐II scores. All filters were patent at 72 h. Clearance and sieving coefficients of small solutes were high and sustained over time, those for larger solutes decreased over 72 h but remained high enough to decrease blood concentrations of solutes up to 25 kDa. Albumin serum levels remained unaffected. Catecholamine doses and SAPS‐II scores decreased significantly. This new hemofilter may improve blood purification in critically ill patients with AKI.
Lesbian disclosure and health care seeking in the United States: A replication study

ABSTRACT The current study explored factors associated with lesbian disclosure to health care providers (HCPs) and engagement in preventative health behaviors by replicating and extending a Canadian path analysis study with a sample of U.S. lesbians. Both patient (education, feminism, global outness, and internalized homophobia) and HCP-related (lesbian-friendly HCPs and patient comfort) factors were either directly or indirectly associated with disclosure and engagement in preventative health behaviors, including avoidance of health-compromising behaviors (e.g., smoking) and health care seeking. Importantly, findings suggest that HCPs—particularly those who are inclusive of lesbian patients—may play a role in assuaging their patients' experiences of minority stress. Overall, the findings were similar to those originally reported in the Canadian study, with the exception of internalized homophobia playing a more visible role in the current study.
Variations in the vascular and biliary structures of the liver: a comprehensive anatomical study

Abstract Purpose: Vascular structures of the liver and the bile ducts are crucial during liver transplantation or liver resection surgery. Here, we report on variations in the vascular structures and bile ducts of 200 patients. Materials and Methods: We reviewed magnetic resonance cholangiopancreatographic and multiple-detector computed tomographic data. Results: Michels type 1 was detected in 54% of the patients. The other most common variations were, respectively, Michels type 5 (13%) and type 2 (11%). Unclassified variations were defined as Michels type 11; 5% of patients were in this group. Type 1 variations in the hepatic portal vein were detected in 76% of our study group. Other common variations were type 2 (9%) and type 3 (8.5%). The left and intermediate hepatic veins united to become a single vein and then joined the inferior vena cava in 64% of the patients. The right, intermediate, and left hepatic veins joined the inferior vena cava separately in 36% of the patients. Type A, which represents the classic anatomy of the bile duct, was observed in 51.5% of our patients. Type C1 and type B were detected in 15% and 12% of patients, respectively. Conclusions: We describe vascular and biliary variations in the livers of our patients.
Low 25-hydroxyvitamin D and normal serum calcium concentrations in Saudi Arabia: Riyadh region.

Serum levels of the circulating form of vitamin D, 25-hydroxyvitamin D, and calcium were measured in 104 Saudis, 44 Jordanians , 17 Egyptians and 10 other subjects aged between 18 and 23 years. All subjects were male university students living in Riyadh for more than 2 years. 25-Hydroxyvitamin D levels were (mean +/- SD) 12.8 +/- 6.3, 11.0 +/- 5.8, 11.9 +/- 6.9 and 11.9 +/- 5.0 ng/ml, respectively. The percentages of subjects with serum 25-hydroxyvitamin D levels below 10 ng/ml were 35, 45, 53 and 50% for normal Saudis, Jordanians , Egyptians and others, respectively. All subjects had normal serum calcium concentrations. There was no correlation between 25-hydroxyvitamin D and serum calcium levels in the subjects investigated. This study indicates a tendency for a low vitamin D status among residents of Saudi Arabia, in spite of abundant sunlight all the year round.
Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype

We tested whether emphysema progression accompanies enhanced tissue loss in other body compartments in 1817 patients from the ECLIPSE chronic obstructive pulmonary disease (COPD) cohort. Clinical and selected systemic biomarker measurements were compared in subjects grouped by quantitative tomography scan emphysema quartiles using the percentage of low attenuation area (LAA%). Lowest and highest quartile patients had amino-acid metabolomic profiles. We related LAA% to 3 years decline in lung function (forced expiratory volume in 1 s (FEV1)), body mass index (BMI), fat-free mass index (FFMI) and exacerbations, hospitalisations and mortality rates. Participants with more baseline emphysema had lower FEV1, BMI and FFMI, worse functional capacity, and less cardiovascular disease but more osteoporosis. Systemic C-reactive protein and interleukin-6 levels were similar among groups, but club cell protein 16 was higher and interleukin-8, surfactant protein D and soluble receptor for advanced glycation end product were lower with more emphysema. Metabolomics differed between extreme emphysema quartiles. Patients with more emphysema had accelerated FEV1, BMI and FFMI decline and more exacerbations, hospitalisations and mortality. COPD patients with more emphysema undergo excessive loss of pulmonary and extrapulmonary tissue, which is probably related to abnormal tissue maintenance. Because of worse clinical outcomes, we propose this subgroup be named the multi-organ loss of tissue (MOLT) COPD phenotype. COPD patients with more severe emphysema lose excessive pulmonary and extrapulmonary tissue http://ow.ly/rbnw30hFwEt
The influence of multiple trials and computer-mediated communication on collaborative and individual semantic recall

ABSTRACT Collaborative inhibition is a phenomenon where collaborating groups experience a decrement in recall when interacting with others. Despite this, collaboration has been found to improve subsequent individual recall. We explore these effects in semantic recall, which is seldom studied in collaborative retrieval. We also examine “parallel CMC”, a synchronous form of computer-mediated communication that has previously been found to improve collaborative recall [Hinds, J. M. , & Payne, S. J. (2016). Collaborative inhibition and semantic recall: Improving collaboration through computer-mediated communication. Applied Cognitive Psychology, 30(4), 554–565]. Sixty three triads completed a semantic recall task, which involved generating words beginning with “PO” or “HE” across three recall trials, in one of three retrieval conditions: Individual–Individual–Individual (III), Face-to-face–Face-to-Face–Individual (FFI) and Parallel–Parallel–Individual (PPI). Collaborative inhibition was present across both collaborative conditions. Individual recall in Recall 3 was higher when participants had previously collaborated in comparison to recalling three times individually. There was no difference between face-to-face and parallel CMC recall, however subsidiary analyses of instance repetitions and subjective organisation highlighted differences in group members' approaches to recall in terms of organisation and attention to others' contributions. We discuss the implications of these findings in relation to retrieval strategy disruption.
Antimicrobial Emulsifier–Glycerol Monolaurate Induces Metabolic Syndrome, Gut Microbiota Dysbiosis, and Systemic Low‐Grade Inflammation in Low‐Fat Diet Fed Mice

SCOPE Glycerol monolaurate (GML) is widely consumed worldwide in the food industry and is considered safe, but for chronic diseases, supporting scientific data remain sparse. This study investigates whether dietary GML induces metabolic syndrome, gut microbiota dysbiosis, and systemic low-grade inflammation. METHODS AND RESULTS GML-induced occurrence of metabolic syndrome, gut microbiota alterations, and systemic low-grade inflammation are investigated. The results demonstrate that GML induced metabolic syndrome by significantly increasing the body weight, weight gain, food intake, body fat, fat droplet size and percentage of epididymal fat, serum triglycerides (TG), LDL, and atherogenic index, and decreasing the body muscle ratio, liver weight, and HDL, compared to the control (CON) group. Meanwhile, GML significantly changed the β-diversity and composition of gut microbiota and upregulated the circulating levels of serum LPS, IL-1β, IL-6, and TNF-α. Importantly, GML significantly decreased Akkermansia muciniphila and Lupinus luteus, and increased Bacteroides acidifaciens, Escherichia coli and the microbial DNA abundance of the ten predicated metabolism pathways involved in carbohydrate, amino acid, and lipid metabolism. CONCLUSION Our results indicate that relatively low-dose GML consumption promotes metabolic syndrome, gut microbiota dysbiosis, and systemic low-grade inflammation, thereby calling for a reassessment of GML usage.
Health Outcomes of Sexual-Minority Youth in Canada: An Overview.

OBJECTIVES The objectives of this review are to (1) document health outcomes among sexual-minority youth (SMY) in Canada; and (2) identify sexual-minority-specific risk and protective factors. DATA SOURCES We conducted a review of Canadian data published after 2005 on the mental, physical and sexual health outcomes of SMY using relevant keywords. A total of 19 empirical studies and 2 research reports was included. DATA SYNTHESIS The study reviewed included 53 to 30 588 respondents (total = 81 567). SMY counted for 15.86% of the total sample. Overall, SMY in Canada show negative health outcomes in proportions varying from 7% to 69.4%, the most common issues being psychological distress and maladjustment. SMY are more likely than their heterosexual peers to report psychological distress/malfunctioning, suicidality, substance misuse, condomless intercourse, pregnancy involvement. Main SMY-specific risk factors were family rejection of one's minority sexual orientation, homophobic bullying and victimization, and internalized homophobia. Among the few protective factors that were reported, school and family connectedness, school safety, parental support and sports involvement decreased the odds of negative health outcomes. CONCLUSIONS Canadian data show that SMY are more likely to experience negative health outcomes than their heterosexual peers. These results are consistent with data from around the world. Recommendations for research and intervention are discussed.
Epilepsy in temporal lobe tumours.

The authors studied a series of 308 patients with temporal lobe tumours (265 intracerebral and 43 extracerebral). The incidence of epilepsy in intracerebral temporal tumours was 41%. Epilepsy occurred most frequently in oligodendrogliomas (84%) and astrocytomas (53%). In 39% of patients various types of epilepsy were noted in the onset period of the tumoural symptomatology, and in 19% of cases epilepsy was the 1st symptom of the disease. The main clinical aspect of the seizures was that of paroxysmal alteration of consciousness without complete loss of awareness. Sensory hallucinations occurred either as aura or as independent manifestations. The most common electroencephalographic aspect was that of focalized slow waves, revealing the existence of the tumour. Sharp waves were recorded in only 6% of cases with epilepsy. In extracerebral temporal tumours, epilepsy was encountered most frequently in the cases of meningiomas of the temporal fossa (70%).
Parent–Adolescent Relationships Among Chinese Immigrant Families: An Indigenous Concept of Qin

This study investigated cultural meanings of positive Chinese parent–child relationships through exploration of an indigenous concept, qin, as experienced by Chinese American adolescents of immigrant parents. Semistructured interviews were conducted with 15 first-generation and second-generation Chinese American high school students of immigrant parents, focusing on adolescents’ descriptions of the meaning of qin and parental behaviors that foster this quality. According to the Chinese American adolescents who were interviewed, being qin with parents was characterized as closeness to parents and a general sense of togetherness and harmony; showing parents their love through respect, obedience, academic effort, and appreciation; and open communication with the parents, particularly about school. This relationship is primarily fostered by parental devotion and sacrifice, particularly for the child’s education, future opportunities, success, and needs. The results highlight the role of child reciprocation of love and devotion for the parents in a qin relationship.
Detoxifying enzyme studies on cotton leafhopper, Amrasca biguttula biguttula (Ishida), resistance to neonicotinoid insecticides in field populations in Karnataka, India

The cotton leafhopper (Amrasca biguttula biguttula Ishida) is considered to be an alarming insect pest causing both quantitative and qualitative loss in cotton. In situ bioassay studies were done and the role of detoxifying enzymes in conferring resistance to neonicotinoid groups of insecticides in low (MUD), medium (DVG), high (HVR) and very high (GLB) pesticide usage areas of Karnataka were determined. Bioassay studies showed that imidacloprid, thiamethoxam, acetamiprid, thiacloprid and clothianidin registered varying levels of resistance for all the locations studied. The resistance ratio was high in imidacloprid (3.35, 8.57, 9.15 and 12.27 fold respectively) and the lowest in dinoferuran (1.86, 5.13, 6.71 and 9.88 fold respectively). Furthermore, the enzyme activity ratio (glutathione-S-transferase) was relatively greater, and corresponded to the higher LC50 values of neonicotinoids for very high, high, medium and low pesticide usage areas. Our study suggested that the higher activity of the detoxifying enzyme in the resistance population of cotton leafhopper apparently has a significant role in endowing resistance to neonicotinoid groups of insecticides. However, this study recommends using neonicotinoids in cotton growing areas with caution.
Differences in Renal Outcomes with ACE Inhibitors in Type 1 and Type 2 Diabetic Patients: Possible Explanations

In type 1 diabetic patients, ACE inhibitors exert a renoprotective effect which appears to be additional to, but not entirely independent of, changes in systemic blood pressure. This effect includes attenuation of albumin excretion rate (AER) as well as prevention or slowing of the rate of decline of the glomerular filtration rate (GFR). In type 2 diabetic patients, the results of ACE inhibition are more varied with some studies showing similar renoprotection to that observed in type 1 diabetes and others showing no additional effect to lowering of systemic blood pressure. This may be due to the diverse manifestations of the disease itself or to renal factors which may modify the response to ACE inhibitors. The major sytemic causes of diversity are variations in age, race and blood pressure. The major renal causes of diversity include changes in the relationship or ‘coupling’ of AER to onset of decline in GFR and a heterogeneity of renal ultrastructural changes in the glomeruli, tubules, interstitium and the renal vasculature. Factors that may be responsible for different renal responses to ACE inhibitors in type 2 diabetes include coexistence of coronary heart disease which may introduce survival bias in long-term studies, a lower specificity of microalbuminuria for diabetic nephropathy, early onset of a decline in GFR in hypertensive or normotensive patients at or prior to the onset of microalbuminuria, a greater contribution of arteriosclerotic changes in renal arteries to decline in renal function, a higher prevalence of nondiabetic renal disease, a higher prevalence of hypertension in the elderly and yet to be characterized genetic factors. These variants of type 2 diabetes may be expected to influence the response to ACE inhibitors either by altering the initial proteinuric response or by altering the hypotensive response. Future studies taking into account the above variables may help to determine the relative importance of the above factors in modifying the renal responses to ACE inhibitors and thereby leading to different renal outcomes in type 1 and type 2 diabetic patients. Such studies may also help to assess the relative importance of changes in systemic blood pressure and intrarenal effects as well as the role of hemodynamic versus structural factors in contributing to differences in renal outcome with ACE inhibitors in type 1 and type 2 diabetes.
The complete mitochondrial genome sequence of Neovison vison (Carnivora: Mustelidae)

Abstract The phylogenetic and taxonomic position of the American mink Neovison vison have long been unclear. In this paper, the complete mitogenome of N. vison was sequenced and characterized. The total length was 16,594 bp and typically consists of 37 genes, including 13 protein-coding genes, 2 rRNAs, 22 tRNA, a large control region (CR) and a light-strand replication origin (OL). Gene contents, locations, and arrangements were identical to those of typical vertebrate. The overall base composition is 33.6%, 25.4%, 27.8% and 13.3% for A, C, T and G, respectively, with a moderate bias on AT content (61.4%). This result is expected to provide useful molecular data and contribute to further taxonomic and phylogenetic studies of Mustelidae and Carnivora.
Data Resource Profile: The Aberdeen Maternity and Neonatal Databank (AMND).

The Aberdeen Maternity and Neonatal Databank (AMND) was initiated in the department of Obstetrics and Gynaecology, University of Aberdeen, in 1950, by the late Professor Sir Dugald Baird, in collaboration with the Medical Research Council’s (MRC’s) Medical Sociology Unit. It was originally set up as a resource for the study of the physiology, pathology and sociology of pregnancy, but the usefulness of the AMND has extended significantly beyond this through linkage with other health and social care records as well as intergenerational and family linkages. Intrauterine exposures can permanently alter physiology and metabolism, leading to higher risk of developing some diseases in adulthood as suggested by the Barker Hypothesis. 1 The AMND is an invaluable resource for life-course epidemiology, especially since it is one of the earliest and most comprehensive obstetric databases. From the year 1950 to the present, this unique database has been recording all the obstetric and fertility-related events occurring in women residing in Aberdeen, Scotland, UK. The data were initially held on punched cards, computerized in the 1970s. Subsequently, in 1986, it was redeveloped onto a relational database known as Scientific Information Retrieval (SIR). The database was re-platformed in 2007 and is now held in a Microsoft SQL server database with an Access Front End. Databank-related personnel are core funded by the University of Aberdeen, and additional funding from funded projects are used to maintain and enhance the databank.
Business analytics maturity of firms: an examination of the relationships between managerial perception of IT, business analytics maturity and success

ABSTRACT This study develops a measure for business analytics (BA) maturity and empirically examines the relationships between managerial perception of IT, BA maturity and BA success. The findings suggest that (1) BA maturity can be measured via BA integration & management support, process-level benefits of BA and technology & data analytics capabilities, (2) BA maturity positively affects organizations’ overall BA success, and (3) managerial perception of IT positively influence organizations’ achievement of BA maturity.