Miracle-dz/UniFAR-FTUs huggingface dataset:
Input–output method to fault detection for discrete-time fuzzy networked systems with time-varying delay and multiple packet losses

The fault detection (FD) problem for discrete-time fuzzy networked systems with time-varying delay and multiple packet losses is investigated in this paper. The communication links between the plant and the FD filter (FDF) are assumed to be imperfect, and the missing probability is governed by an individual random variable satisfying a certain probabilistic distribution over the interval [0 1]. The discrete-time delayed fuzzy networked system is first transformed into the form of interconnect ion of two subsystems by applying an input–output method and a two-term approximation approach, which are employed to approximate the time-varying delay. Our attention is focused on the design of fuzzy FDF (FFDF) such that, for all data missing conditions, the overall FD dynamics are input–output stable in mean square and preserves a guaranteed performance. Sufficient conditions are first established via H∞ performance analysis for the existence of the desired FFDF; meanwhile, the corresponding solvability conditions for the desired FFDF gains are characterised in terms of the feasibility of a convex optimisation problem. Moreover, we show that the obtained criteria based on the input–output approach can also be established by applying the direct Lyapunov method to the original time-delay systems. Finally, simulation examples are provided to demonstrate the effectiveness of the proposed approaches.
The usefulness of the GlideScope video laryngoscope in the education of conventional tracheal intubation for the novice

The aim of this study is to evaluate the usefulness of the GlideScope video laryngoscope (GVL) as a tool to educate novice users in conventional tracheal intubation. 41 premedical students with no previous experience in tracheal intubation participated in this prospective, randomised and controlled study. Group M (n = 20) was instructed in tracheal intubation by using the Macintosh laryngoscope and group G (n = 21) was instructed by using both the GVL and the Macintosh laryngoscope. There was no significant difference in tracheal intubation performance using the Macintosh laryngoscope between the two groups. However, the GVL facilitates the education of tracheal intubation because it shows the same anatomical structure for both instructor and trainee simultaneously on a real-time basis. This aspect makes the trainee feel more comfortable learning the material with a high degree of satisfaction. Introducing GVL to conventional intubation education for novice users could increase the satisfaction of trainees during the procedure, especially as a way to understand critical anatomical structures.
The risk of the sovereign debt default: the Eurozone crisis 2008–2013

ABSTRACT We investigate the relationship of the market pricing of sovereign risk to default, through credit default swap (CDS) spreads for 16 Eurozone countries during 2008q1–2013q3. We take into account, through appropriate non-linear generalized method of moments (GMM) estimations the endogeneity problem. We focus on ‘fiscal space’ (DEBT or FISCAL), and the downgrade announcements (DOWN). We find DEBT (FISCAL) to have significant (insignificant) effects on the CDS concave function, as well as, DOWN in a linear one. It has also been confirmed significant pricing discrimination between South and West Euro Area Periphery (SWEAP) and the core Eurozone, highlighting asymmetries discovered either by the respective size of estimated DEBT coefficients or by the significant effects of DOWN that have only on CDS of SWEAP countries. The current account balance or the inflation rate, as well as, relevant interaction terms seem not to affect the spreads of the EMU. These findings, together with the estimated structural change on CDS pattern in early 2011, coinciding with significant either the DOWN in the pre-crisis period (2008–2010) or the DEBT in the post-crisis one (2011–2013) on the CDS, seem to be consistent with self-fulfilling crises literature and the inherent vulnerability of EMU, on other words, the ‘fragility hypothesis of the Eurozone’.
Exploring the motivations and problems of farmers for conversion to organic farming in Iran

ABSTRACT Identifying and understanding the heterogeneity of the motivations and problems of farmers is critical for designing better strategies as societies strive to convert towards agricultural approaches such as organic farming and sustainable intensification. The objective of this research is to explore the motivations and problems for conversion to organic farming in Iran. Survey data of Iranian organic producers were collected during the first half of 2015. These data were used to find the statistical determinants of motivations and problems for organic production. Results suggest that economic motivations, health, safety concerns and environmental issues are the predominant motives for conversion, while social and ethical motives are of lesser importance. Problems experienced during conversion relate to marketing, agronomic issues, lack of governmental and institutional support, negative pressure from other farmers and farm groups, and lack of physical and financial capital. To prosper, the Iranian organic sector must overcome fundamental economic problems and challenges. Some of the strategies recommended include the development and scaling up of sustainable intensification, strategies that encourage farmers’ markets and community-supported agriculture (CSA) initiatives, and sustainable procurement.
Treatment and disease management of multiple sclerosis patients: A review for nurse practitioners

BACKGROUND AND PURPOSE This review discusses the role of the nurse practitioner (NP) in evaluating the clinical effects, potential side effects, and monitoring requirements for treatment options in multiple sclerosis (MS) and provides guidance on how to help patients understand these issues. METHODS A literature search was conducted on PubMed to identify publications on monitoring and disease management of MS patients. Additional resources included drug information web sites and package inserts. CONCLUSIONS NPs play an active role in the management of MS patients via effective monitoring and communication throughout the patient's treatment regimen and disease course. In the shared decision-making model of MS treatment, NPs ensure that patients understand the implications of their disease-modifying therapies (DMTs). As patients move through treatments during the course of their disease, the importance of this role increases, and it is critical that NPs follow the guidelines in each medication's product label and take into account any potential lingering effects of prior medications. IMPLICATIONS FOR PRACTICE It is critical for NPs to promote patient adherence, to ensure that patients understand treatment side effects and monitoring requirements, and to take sequencing and reversibility implications of DMTs into account when making clinical decisions.
Toxicity and Metabolism of the Chloral-Derived Mammalian Alkaloid 1-Trichloromethyl-1,2,3,4-tetrahydro-β-carboline (TaClo) in PC12 Cells

Chloral-derived β-carbolines, which are structurally similar to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 5), are discussed to contribute to neuronal cell death in idiopathic Parkinson’s disease. The cytotoxicity of 1-trichloromethyl- 1,2,3,4-tetrahydro-β-carboline (TaClo, 4) to neuronal-like clonal pheochromocytoma PC12 cells was examined by the determination of lactate dehydrogenase (LDH) release. After incubation for 48 h, 4 showed a strong dose-dependent cytotoxic activity towards PC12 cells with an ED50 value of 230 μᴍ. In PC12 cells reductive dehalogenation of 4 was observed giving rise to the formation of 1-dichloromethyl-1,2,3,4-tetrahydro-β-carboline (6) as a main TaClo metabolite exhibiting a cytotoxic potential comparable to that of TaClo. An X-ray structure analysis, performed for the trifluoroacetyl derivative of 6, revealed the N-substituent of such a highly chlorinated agent to be dramatically pushed out of the β-carboline ring ‘plane’ due to the high steric demand of the huge dichloromethyl group at C(1).
Economic Downturns and Babiesâ€™ Health

We study the impact of provincial unemployment levels on birthweight using a sample of over 50,000 respondents from Lifelines â€“ a cohort study from the northeastern Netherlands and we allow the effects to differ by babiesâ€™ gender. We find that during periods of high unemployment fertility decreases and male babies are born with lower birthweight. The effect of unemployment on birthweight is particularly strong for boys born to older mothers and for babies born to smoking mothers. In addition, we study whether the effects are attributable to changes in cohort composition or in health behaviour of pregnant women. Our results indicate that even though the women who are pregnant during economic downturns are more likely to have higher socio-economic status, the total effect of economic downturns on babiesâ€™ health is negative.
Enrichment of Female Germline Stem Cells from Mouse Ovaries Using the Differential Adhesion Method

Background/Aims: The isolation and establishment of female germline stem cells (FGSCs) is controversial because of questions regarding the reliability and stability of the isolation method using antibody targeting mouse vasa homologue (MVH), and the molecular mechanism of FGSCs self-renewal remains unclear. Thus, there needs to be a simple and reliable method for sorting FGSCs to study them. Methods: We applied the differential adhesion method to enrich FGSCs (DA-FGSCs) from mouse ovaries. Through four rounds of purification and 7-9 subsequent passages, DA-FGSC lines were established. In addition, we assessed the role of the phosphoinositide-3 kinase (PI3K)-AKT pathway in regulating FGSC self-renewal. Results: The obtained DA-FGSCs spontaneously differentiated into oocyte-like cells in vitro and formed functional eggs in vivo that were fertilized and produced healthy offspring. AKT was rapidly phosphorylated when the proliferation rate of FGSCs increased after 10 passages, and the addition of a chemical PI3K inhibitor prevented FGSCs self-renewal. Furthermore, over-expression of AKT-induced proliferation and differentiation of FGSCs, c-Myc, Oct-4 and Gdf-9 levels were increased. Conclusions: The differential adhesion method provides a more feasible approach and is an easier procedure to establish FGSC lines than traditional methods. The AKT pathway plays an important role in regulation of the proliferation and maintenance of FGSCs. These findings could help promote stem cell studies and provide a better understanding of causes of ovarian infertility, thereby providing potential treatments for infertility.
Exchange-rate volatility and Malaysian-Thai bilateral industry trade flows

Purpose After the fall of fix exchange rate regime in early 1970s, the nexus between the exchange rate volatility and trade flows has been of a great interest to the policy makers and researchers. Resultantly an extensive literature is available on the topic. However, the research findings are inconclusiveness so far. The purpose of this paper is to examine the exchange-rate volatility and bilateral industry trade link between the two important countries of Southeast Asia, i.e. Malaysia and Thailand. Design/methodology/approach This study employs Generalized Autoregressive Conditional Heteroskedasticity (GARCH) (1, 1) to measure exchange rate volatility and autoregressive distributed lag (ARDL) model to study the relationship between exchange rate volatility and trade flows. ARDL approach is suitable to accommodate the mix cases (i.e. stationary and first difference stationary). The paper considers 62 Malaysian exporting and 60 Malaysian importing industries with Thailand over the monthly period 2000-2013. Findings Findings suggest the influence of exchange-rate volatility on the trade flows in a limited number of industries. Large industries like instruments and apparatus experience negative influence from exchange-rate volatility. Originality/value Past literature continued to be inconclusiveness on the nexus between exchange-rate volatility and trade flows due to its over-reliance on the aggregated data. Besides, the past studies are more based on quarterly or yearly frequency data. These issues contribute to the aggregation bias. This research focusses on a country bilateral trade pair, using industry level disaggregated monthly data. Such research is rare in Malaysian-Thai bilateral trade context. This study uses a suitable estimation approach and also draws valuable implications.
Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells

CD1d is a key antigen‐presenting molecule involved in the selection and activation of a highly conserved T cell subset known as NK T cells. In this study, we analyzed the expression, regulation and function of human CD1d by various antigen‐presenting cells (APC) of myeloid origin, including circulating monocytes, monocyte‐derived dendritic cells and macrophages. CD1d was expressed as a mature glycoprotein by these cells, and unlike the other members of the human CD1 family its expression was constitutive and was not strongly up‐regulated by GM‐CSF and IL‐4 or a range of other cytokines. Despite their remarkably low surface expression of CD1d, all myeloid lineage cells tested were extremely potent APC for responses of NK T cell clones to the synthetic glycolipid antigen, α‐galactosyl ceramide. Prominent localization of CD1d to the endocytic system of monocyte lineage cells was observed, and functional studies suggested that this was important for achieving efficient antigen loading onto CD1d. Overall, these results support the view that monocyte lineage cells are important stimulators of CD1d‐restricted immune responses, while also underscoring the unique regulation of CD1d expression by these cells.
Blood–brain barrier and traumatic brain injury

The blood–brain barrier (BBB) is an anatomical microstructural unit, with several different components playing key roles in normal brain physiological regulation. Formed by tightly connected cerebrovascular endothelial cells, its normal function depends on paracrine interactions between endothelium and closely related glia, with several recent reports stressing the need to consider the entire gliovascular unit in order to explain the underlying cellular and molecular mechanisms. Despite that, with regard to traumatic brain injury (TBI) and significant events in incidence and potential clinical consequences in pediatric and adult ages, little is known about the actual role of BBB disruption in its diverse pathological pathways. This Mini‐Review addresses the current literature on possible factors affecting gliovascular units and contributing to posttraumatic BBB dysfunction, including neuroinflammation and disturbed transport mechanisms along with altered permeability and consequent posttraumatic edema. Key mechanisms and its components are described, and promising lines of basic and clinical research are identified, because further knowledge on BBB pathological interference should play a key role in understanding TBI and provide a basis for possible therapeutic targets in the near future, whether through restoration of normal BBB function after injury or delivering drugs in an increased permeability context, preventing secondary damage and improving functional outcome. © 2013 Wiley Periodicals, Inc.
Determinants of Emigration: Evidence from Egypt

This paper analyzes the determinants of emigration at the individual and household level, using three waves of the Egyptian labor market panel survey (ELMPS) covering the 1998-2012 period. Exploiting the panel structure of the data allows us to reduce the risk of reverse causality, and to estimate the effect of migrant networks more accurately than in existing studies based on cross-sectional data. We confirm, in the Egyptian context, that migrants abroad are positively selected on the wealth of the origin household, due to migration costs; and that the growth of a network of past emigrants from the same community mitigates this positive selection, increasing the propensity to migrate among poorer households. We also offer a novel insight on the linkages between emigration decision and home country’s labor market conditions. We show that unemployment and informal employment appear as the main incentives to emigrate. This suggests that the scarcity of “quality jobs”, in particular on the skilled labor market, is one important factor driving emigration flows in Egypt.
Galen's “Anastomosis” revisited

This study aimed to examine the incidence and contribution to the innervation of the larynx from Galen's “Anastomosis” (GA), which is the direct connection between the dorsal branches of the internal laryngeal nerve (ILN) and the recurrent laryngeal nerve (RLN). Fifty adult laryngeal specimens were micro‐dissected. The diameter of the ILN and RLN were measured immediately after each had given off their muscular branches to form GA. The incidence of GA was 81%. The average diameter of the ILN after giving off muscular branches to form GA was 1.28 mm (right) and 1.27 mm (left) while the average diameter of the RLN after giving off muscular branches to form GA was 0.65 mm (right) and 0.68 mm (left). The weighted mean incidence of GA (77.3%) calculated from a review of the literature concurred with the present finding of 81%. The ILN and RLN supplied the laryngeal musculature. According to the results obtained; it appears that the ILN may provide a greater contribution to the connection between the ILN and RLN as the morphometric contribution from the ILN was larger in comparison to the RLN. In addition, the authors propose a suitable term viz. the “communicating branch” as opposed to the commonly used misnomer GA to describe the connection between the dorsal branch of the RLN and the ILN, based on the definition that an “Anastomosis” refers to blood vessels and that a single connection exists between the dorsal branch of the RLN and ILN. Clin. Anat. 25:722–728, 2012. © 2011 Wiley Periodicals, Inc.
Functions of Family-22 Carbohydrate-Binding Module in Clostridium thermocellum Xyn10C

Clostridium thermocellum xylanase Xyn10C (formerly XynC) is a modular enzyme, comprising a family-22 carbohydrate-binding module (CBM), a family-10 catalytic module of the glycoside hydrolases, and a dockerin module responsible for cellulosome assembly consecutively from the N-terminus. To study the functions of the CBM, truncated derivatives of Xyn10C were constructed: a recombinant catalytic module polypeptide (rCM), a family-22 CBM polypeptide (rCBM), and a polypeptide composed of the family-22 CBM and CM (rCBM–CM). The recombinant proteins were characterized by enzyme and binding assays. Although the catalytic activity of rCBM–CM toward insoluble xylan was four times higher than that of rCM toward the same substrate, removal of the CBM did not severely affect catalytic activity toward soluble xylan or β-1,3-1,4-glucan. rCBM showed an affinity for amorphous celluloses and insoluble and soluble xylan in qualitative binding assays. The optimum temperature of rCBM–CM was 80 °C and that of rCM was 60 °C. These results indicate that the family-22 CBM of C. thermocellum Xyn10C not only was responsible for the binding of the enzyme to the substrates, but also contributes to the stability of the CM in the presence of the substrate at high temperatures.
Association between thyroid hormones, insulin resistance, and metabolic syndrome.

OBJECTIVE To determine the association between thyroid hormones, insulin resistance, and metabolic syndrome in euthyroid women. METHODS Forty-five women with no past medical history were studied in this cross-sectional study at the Department of Endocrinology, Medwin Hospitals, Hyderabad, India, from August 2008 to September 2008. The body fat was estimated using bio-impedance method, and fasting blood sample was analyzed for total triiodothyronine (T3), total thyroxine (T4), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), lipid profile, insulin, and glucose. RESULTS The mean age of the participants was 32.6 +/= 9.6 years with a body mass index (BMI) of 29.9 +/= 3.8 kg/m2. Evidence of homeostasis model assessment index for insulin resistance (HOMA-IR) more than 3 was seen in 34 (75%) and metabolic syndrome in 29 (64%) participants. Total T3 showed a positive correlation with triglycerides, low density lipoprotein- cholesterol (LDL-C), total cholesterol, insulin, HOMA-IR and negatively with body fat. Thyroid-stimulating hormone correlated positively with BMI, insulin, HOMA-IR, LDL-C and negatively with HDL-cholesterol (p<0.05). Free triiodothyronine correlated positively with waist circumference and T4 did not correlate with metabolic syndrome parameters. CONCLUSION Our preliminary data show an association between thyroid hormones and some components specific of the metabolic syndrome in euthyroid women. Total triiodothyronine and TSH correlated more with variables of metabolic syndrome than FT3 and T4.
Gene targeting with a replication-defective adenovirus vector

Wide application of the gene-targeting technique has been hampered by its low level of efficiency. A replication-defective adenovirus vector was used for efficient delivery of donor DNA in order to bypass this problem. Homologous recombination was selected between a donor neo gene inserted in the adenovirus vector and a target mutant neo gene on a nuclear papillomavirus plasmid. These recombinant adenoviruses allowed gene transfer to 100% of the treated cells without impairing their viability. Homologous recombinants were obtained at a level of frequency much higher than that obtained by electroporation or a calcium phosphate procedure. The structure of the recombinants was analyzed in detail after recovery in an Escherichia coli strain. All of the recombinants examined had experienced a precise correction of the mutant neo gene. Some of them had a nonhomologous rearrangement of their sequences as well. One type of nonhomologous recombination took place at the end of the donor-target homology. The vector adenovirus DNA was inserted into some of the products obtained at a high multiplicity of infection. The insertion was at the end of the donor-target homology with a concomitant insertion of a 10-bp-long filler sequence in one of the recombinants. The possible relationship between these rearrangements and the homologous recombination is discussed. These results demonstrate the applicability of adenovirus-mediated gene delivery in gene targeting and gene therapy.
Issues in the Recognition versus Disclosure of Financial Information Debate

Abstract Empirical evidence from the academic literature on capital market effects of financial information placement (i.e., recognition on the face of the primary financial statements versus disclosure in the notes to the financial statements) is not straightforward. Therefore, the purpose of this paper is to contribute to the recognition versus required disclosure debate in a standard-setting context by exploring possible reasons for perceived differences between recognized and disclosed amounts. These differences, in our view, arise due to demonstrated auditors’ greater tolerance for misstatement in disclosed amounts, allowed noncompliance with disclosure requirements even in strong enforcement regimes, lesser care that preparers of financial statements devote to disclosures relative to recognized items as well as behavioural factors and differential processing costs related to the users of financial information. We believe that these arguments strengthen the case for the general preference for the recognition of financial information in the standard-setting context. The original scientific contribution of this paper is to systematically identify the reasons for the differences between recognized and disclosed amounts in financial statements. As such, this paper may provide a suitable basis for the justification of certain conceptual changes in the field of international accounting standards that are currently underway.