Miracle-dz/UniFAR-FTUs huggingface dataset:
Mortality in participants and non-participants of a multifactorial prevention study of cardiovascular diseases: a 28 year follow up of the Helsinki Businessmen Study.

OBJECTIVE--To investigate pretrial risk factors and long term mortality (1964-1992) in participants and non-participants of a multifactorial primary prevention trial. DESIGN--A prospective study among 3313 initially healthy businessmen. During the 1960s (1964 onwards), 3490 healthy male business executives born between 1919 and 1934 participated in voluntary health checks at the Institute of Occupational Health in Helsinki. From that period cardiovascular disease (CVD) risk factors were available in 3313 men. In the beginning of the 1970s these men were invited to join a multifactorial primary prevention trial of CVD. Six groups were formed: (I) healthy participants in a high risk intervention group (n = 612), and (II) their randomised control group (n = 610); (III) a non-participant low risk group (n = 593); (IV) an excluded group with signs of CVD (n = 563); (V) a refused group (n = 867); and (VI) dead (n = 68). Groups I and II participated in the five year prevention trial which started in 1974. Other groups were followed up through registers, with no personal contact. MEASUREMENTS--Cardiovascular risk factors during the 1960s. Mortality follow up using national registers up to 31 December, 1992. MAIN RESULTS--Baseline risk factors were lowest in the low risk group, highest in the excluded group, intermediate and comparable in other groups. Eighteen-year (1974-1992) mortality (per 1000) was 79.3, 106.6, 155.2, 179.9, and 259.3 in the low risk, control, intervention, refused, and excluded groups, respectively (P < 0.001). In the whole population of 3313 men, the 28-year (1964-1992) total (n = 577) and coronary deaths (n = 199) were significantly predicted by smoking, blood pressure, and cholesterol; cancer deaths (n = 163) by smoking only; and violent deaths (n = 83) by none of the risk factors. One-hour postload glucose was significantly associated with total mortality in the intervention group only. When the intervention and control groups were included in the same model, the effect of group on total mortality tended to be dependent on the 1 h blood glucose value (P = 0.06 for the group by 1 h glucose interaction term). CONCLUSION--The traditional risk factors (smoking, blood pressure, and cholesterol) are significantly associated with 28-year mortality in this high social class population with previous health education. Conversely, a "clustering" of low risk factors predicted low total, coronary, and cancer mortality. The findings on 1 h blood glucose suggest that factors related to glucose tolerance explain in part the excess mortality in the intervention group compared with the control group.
Evaluating within‐population variability in behavior and demography for the adaptive potential of a dispersal‐limited species to climate change

Abstract Multiple pathways exist for species to respond to changing climates. However, responses of dispersal‐limited species will be more strongly tied to ability to adapt within existing populations as rates of environmental change will likely exceed movement rates. Here, we assess adaptive capacity in Plethodon cinereus, a dispersal‐limited woodland salamander. We quantify plasticity in behavior and variation in demography to observed variation in environmental variables over a 5‐year period. We found strong evidence that temperature and rainfall influence P. cinereus surface presence, indicating changes in climate are likely to affect seasonal activity patterns. We also found that warmer summer temperatures reduced individual growth rates into the autumn, which is likely to have negative demographic consequences. Reduced growth rates may delay reproductive maturity and lead to reductions in size‐specific fecundity, potentially reducing population‐level persistence. To better understand within‐population variability in responses, we examined differences between two common color morphs. Previous evidence suggests that the color polymorphism may be linked to physiological differences in heat and moisture tolerance. We found only moderate support for morph‐specific differences for the relationship between individual growth and temperature. Measuring environmental sensitivity to climatic variability is the first step in predicting species' responses to climate change. Our results suggest phenological shifts and changes in growth rates are likely responses under scenarios where further warming occurs, and we discuss possible adaptive strategies for resulting selective pressures.
Prescription Stimulant Misuse and ADHD Symptomatology Among College Students in Iceland

Objective: Misuse of prescription stimulant medication is a prevalent problem on American college campuses; however, few studies have been conducted beyond the United States. Although Iceland has the highest methylphenidate prescription rates in the world, prevalence of stimulant misuse within the Icelandic college student population remains to be investigated. Method: We examined the prevalence of prescription stimulant misuse among N = 521 college students in Iceland, using an online survey. Results: Overall prevalence of lifetime stimulant misuse was approximately 13%; 11% among participants without a prescription for stimulant medication, and 42% among participants holding a prescription. The primary reported reason for misuse was academic enhancement; risk factors included male sex, anxiety symptoms, and ADHD symptomatology. Conclusion: The present findings have implications for public health policy in Iceland, particularly as it relates to the college population. Prevention and intervention programs that provide college students with safer strategies to manage academic demands are warranted.
On Extending the Wave Variable Method to Multiple-DOF Teleoperation Systems

It is well known that providing a human operator with contact force information can significantly improve task performance in a teleoperation system. Unfortunately, time delay is a serious problem for such systems. Even a small time delay in a bilateral teleoperation system will generally degrade the system's performance and cause instability. Consequently, without some form of compensation for time delay, latencies in a teleoperation system would preclude the use of force feedback. Fortunately, there are approaches based on scattering theory and passivity that can compensate for time delay and allow the use of force feedback in teleoperation systems with latencies. In particular, the wave variable method is a passivity-based approach that guarantees stability for any fixed time delay. Since its introduction, the wave variable method has been augmented with predictors to compensate for variable time delay. The wave variable formalism has also been extended to multiple-DOF systems by replacing scalar damping constants with a family of impedance matrices. In this paper, the authors generalize this last approach to include a larger family of impedance matrices. The paper includes a complete derivation of the extended family of impedance matrices as well as simulation and experimental results to illustrate the approach.
Crafting Trust

In this article, the authors evaluate the origins of generalized trust. In addition to examining individual-level determinants, the analytic focus is on the political-institutional context. In contrast to most of the analyses to date, the authors conduct hierarchical analyses of the World Values Surveys (1995-1997 and 1999-2001) to simultaneously test for differences among respondents in 58 countries and for variations in levels of trust between countries with different institutional configurations. In addition, the authors extend the institutional theory of trust by introducing the power-sharing quality of institutions—a rather neglected institutional dimension hitherto. With regard to the most important contextual factors, the authors find that countries whose authorities are seen as incorruptible, whose institutions of the welfare state reduce income disparities, and whose political interests are represented in a manner proportional to their weight have citizens who are more likely to place trust in one another.
The URICA as a measure of motivation to change among treatment-seeking individuals with concurrent alcohol and cocaine problems.

The original 4-factor structure of the University of Rhode Island Change Assessment (URICA; C. C. DiClemente & S. O. Hughes, 1990) was replicated, and the scale's internal consistency was found to be acceptable in a sample of 106 cocaine- and alcohol-dependent participants receiving either disulfiram or no medication in a psychotherapy trial. In addition, participants categorized as having high Committed Action (CA), a new URICA composite, had a significantly greater percentage of days abstinent from both alcohol and cocaine (85.6%) than low-CA participants (72.7%, p < .01). Furthermore, a significant Treatment x CA interaction emerged, suggesting that low-CA participants had better outcomes than those with high CA when assigned to medication, whereas high-CA participants fared equally well with or without medication.
Lipoprotein(a) and asymptomatic carotid artery disease. Evidence of a prominent role in the evolution of advanced carotid plaques: the Bruneck Study.

BACKGROUND AND PURPOSE Elevated levels of lipoprotein(a) [Lp(a)] have been reported in association with symptomatic coronary and carotid artery disease. Relevancy of Lp(a) as a risk predictor of presymptomatic atherosclerosis in general populations is not well established. METHODS Serum Lp(a) distribution and its relation to sonographically assessed carotid atherosclerosis were examined in a random sample of 885 men and women aged 40 to 79 years (Bruneck Study). RESULTS Logistic regression analysis revealed a binary-type association between Lp(a) and carotid artery disease, with the threshold level of Lp(a) for an enhanced atherosclerosis risk defined at 32 mg/dL. The strength of relation increased with advancing severity of carotid atherosclerosis (odds ratios for Lp(a), 1.8 for nonstenotic and 4.7 for stenotic carotid artery disease; P < . 001). Lp(a) was unaffected by environmental factors except for a significant decrease in women taking hormone replacement therapy (P < .05). In a multivariate approach, Lp(a) turned out to be an independently significant predictor of carotid atherosclerosis (P < .001). No differential effect of Lp(a) on atherosclerosis (effect modification) was observed for sex, age, low-density lipoprotein cholesterol, apolipoprotein A-I and B, fasting glucose, diabetes, or hypertension. However, the Lp(a)-atherosclerosis relation was significantly modified by fibrinogen (P < .01) and antithrombin III (P < .05). CONCLUSIONS The present study demonstrates a strong and independent association between elevated Lp(a) levels and carotid atherosclerosis in a large randomized population and provides evidence of a potential role of Lp(a) in the evolution of carotid stenosis. Apart from atherogenicity of Lp(a) cholesterol, interference with fibrinolysis of atheroma-associated clots and fibrin deposits in the arterial wall may achieve pathophysiological significance.
Experimental study of scattering from characterized random surfaces

An experimental investigation of light scattering from random rough surfaces is described. The surfaces, whose height fluctuations approximately follow Gaussian statistics, are fabricated in photoresist with a metal overcoating. When the lateral correlation length is larger than a wavelength and the surface slopes are mild, measurements of diffuse scattering are found to agree with the Beckmann theory, as long as the angle of incidence is not too large. For other surfaces that have stronger slopes, depolarization and enhanced backscattering may be observed in the diffuse scattering. Though we are unaware of theoretical calculations that compare with the measurements, the effects of multiple scattering are shown to be consistent with the major features of the observations.
Combined karyotyping, CGH and M‐FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a rare aggressive neuroendocrine tumor of the skin. Cytogenetic studies have indicated that deletions and unbalanced translocations involving chromosome 1 short arm material occur in 40% of the investigated cases. Recurrent chromosomal imbalances detected by comparative genomic hybridization (CGH) analysis were loss of 3p, 10q, 13q and 17p and gains of 1q, 3q, 5p and 8q. In order to study genomic aberrations occurring in MCC in further detail, we combined karyotyping, CGH and multiplex‐fluorescence in situ hybridization (M‐FISH), a strategy that proved to be successful in the analysis of other malignancies. Analysis of 6 MCC cell lines and 1 MCC tumor revealed mostly near‐diploid karyotypes with an average of 5 chromosomal rearrangements. The observed karyotypic changes were heterogeneous, with 3–27 breakpoints per case, leading to imbalance of the involved chromosomal regions that was confirmed by CGH. Chromosomal rearrangements involving the short arm of chromosome 1, the long arm of chromosome 3 and gain of 5p material were the most frequently observed abnormalities in our study. In keeping with previous observations, this series of MCCs showed no evidence for high‐level amplification. We provid a detailed description of chromosomal translocations occurring in MCC that could be useful to direct future intensive investigation of these chromosomal regions. © 2002 Wiley‐Liss, Inc.
Discontinuation of Medication Overuse in Headache Patients: Recovery of Therapeutic Responsiveness

Dear Sir We read with great interest the paper by Zeeberg et al. (1), in which they describe the treatment outcomes in patients with medication overuse headache (MOH), who were simply withdrawn from the offending medication without any other pharmacological intervention. They identified 337 individuals in their headache clinic with an initial diagnosis of MOH. A total of 121 subjects were excluded because they did not remain medication free for 2 months, leaving 216 patients, of whom 45% had a reduction in headache frequency by mere discontinuation of the offending drug, 48% were unchanged following withdrawal and 7% had worsening headaches. Overall, there was a 46% decrease in headache frequency from the first visit to discharge (P < 0.0001). Patients with no improvement 2 months after complete drug withdrawal (n = 88) subsequently responded to pharmacological and/or non-pharmacological prevention with a 26% decrease in headache frequency as measured from the end of withdrawal to discharge (P < 0.0001). At discharge, 47% were on prevention. Former non-responders to medical prevention had a 49% decrease in headache frequency from first visit to discharge (P < 0.0001), whereas those who had never received prevention had a 56% reduction (P < 0.0001). Later in the paper, they report that ‘these results are somewhat smaller than the 74% decrease in headache frequency found by Bigal et al. (2) . in patients with so-called transformed migraine’. We would like, however, to emphasize that the data are not comparable. Although the definition of transformed migraine with medication overuse is very similar to the definition of medication overuse as used by Zeeberg et al., we assessed outcomes after 1 year, not 2 months, following detoxification. We found that after 1 year, those who had stopped their overuse had a reduction in the number of headache days of the order of 73.7%, vs. just 17.2% in those who continued to overuse. A similar trend was found regarding the headache score (frequency multiplied by severity— Fig. 1). However, different from Zeeberg, we used preventive medications at the very beginning. Therefore, this 73% improvement encompasses the long-term benefits of detoxification associated with 1 year of preventive medication. Because the subjects that received preventive medication but were not detoxified showed a much smaller magnitude of improvement, we indirectly demonstrated the importance of detoxification. Therefore, it seems to us that both papers are amazingly consistent and more similar than different, supporting the importance of detoxification in the treatment of medication overuse headache.
Electronic media exposure and its association with activity-related outcomes in female adolescents: cross-sectional and longitudinal analyses.

BACKGROUND Few investigations have assessed in adolescent girls the cross-sectional and longitudinal associations between elevated exposure to electronic media (EM) and activity-related outcomes such as compliance with physical activity (PA) standards or cardiorespiratory fitness (CRF). METHODS Four-hundred thirty-seven white and African American girls were assessed at the 8th, 9th, and 12th grades. PA and EM (TV/video watching, electronic games, Internet use) were self-reported, and CRF was estimated using a cycle-ergometer test. Hi EM exposure was defined as >or=four 30-minute blocks/d. RESULTS 8th-, 9th-, and 12th-grade girls in the Hi EM group showed lower compliance with PA standards and had lower CRF than the Low EM group (P<or=.03). Girls reporting Hi EM exposure at 8th and 9th grades had lower vigorous PA and CRF levels at 12th grade than girls reporting less EM exposure (P<or=.03). CONCLUSION Girls reporting exposure to EM for 2 or more hours per day are more likely to exhibit and maintain low PA and CRF levels throughout adolescence. These results enhance the scientific basis for current public health recommendations to limit adolescent girls' daily exposure to television, electronic games, and Internet use to a combined maximum of 2 hours.
ESTABLISHMENT OF AN IMMORTALIZED HUMAN-LIVER ENDOTHELIAL CELL LINE WITH SV40T AND hTERT

Background and Aims. Liver endothelial cells (LECs) perform an essential role in important pathophysiologic functions in the liver. Establishment of a human LEC line facilitates advances in LEC research. Here, we present immortalization of human LECs using retroviral gene transfer of simian virus 40 large T antigen (SV40T) and human telomerase reverse transcriptase (hTERT). We also demonstrate excision of SV40T and hTERT with TAT-mediated Cre/loxP recombination and subsequent cell sorting. Methods. First, human LECs were transduced with a retroviral vector somatostatin receptor (SSR)#69 expressing SV40T and hygromycin-resistance genes flanked by a pair of loxA recombination targets. Then, cells were retrovirally superinfected with SSR#197 encoding hTERT and green fluorescent protein (GFP) cDNAs that were intervened by two loxBs. One SV40T-and hTERT-immortalized LEC clone, TMNK-1, was established and analyzed for its biologic characteristics. Results. The cells were hygromycin-resistant and uniformly positive for GFP expression. TMNK-1 expressed EC markers, including factor VIII, vascular endothelial growth factor receptors (flt-1, KDR/Flk-1), and CD34, showed uptake of Di-I-acetylated-low-density lipoprotein and angiogenic potential in Matrigel assays. After lipopolysaccharide treatment, TMNK-1 produced tumor necrosis factor (TNF)-&agr; and interleukin (IL)-6 and exhibited increased expression of intra-cellular adhesive molecule-1, vascular cellular adhesive molecule-1, and VE-cadherin. After treatment with TAT-Cre recombinase fusion protein, approximately 60% of TMNK-1 was negative for GFP expression, and subsequent cell sorting of this population for GFP allowed for collection of the reverted form of TMNK-1. Conclusions. This study demonstrates the utility and efficiency of the reversible immortalization procedure to expand primary human LECs for basic studies.
Challenges of Applying the SHEA/HICPAC Metrics for Multidrug-Resistant Organisms to a Real-World Setting

Objective. To test in a real-world setting the recommendations for measuring infection with multidrug-resistant organisms (MDRO) from the Society for Healthcare Epidemiology of America (SHEA) and the Centers for Disease Control and Prevention's Healthcare Infection Control Practices Advisory Committee (HICPAC). Methods. Using data from 3 hospital settings within a healthcare network, we applied the SHEA/HICPAC recommendations to measure methicillin-resistant Staphylococcus aureus (MRSA) infection and colonization. Data were obtained from the hospitals' electronic surveillance system and were supplemented by manual medical record review as necessary. Additionally, we tested (1) different definitions for nosocomial incidence, (2) the effect of excluding patients not at risk from the denominator for hospital-onset incidence, and (3) the appropriate time period to use when including or excluding patients with a prior history of MRSA infection or colonization from nosocomial rates. Negative binomial regression models were used to test for differences between rate definitions. A rating scale was created for each metric, assessing the extent to which manual or electronic data elements were required. Results. There was no statistically significant difference between using 72 hours or 3 calendar days as the cutoff to define hospital-onset incidence. Excluding patients not at risk from the denominator when calculating hospital-onset incidence led to statistically significant increases in rates. When excluding patients with a prior history of MRSA infection or colonization from nosocomial incidence rates, rates were similar regardless of whether we looked at 1, 2, or 3 years' worth of prior data. Conclusions. The SHEA/HICPAC MDRO metrics are useful but can be challenging to implement. We include in our description of the data sources and processes required to calculate these metrics information that may simplify the process for institutions.
Effect of low nutrition on size of striated muscle fibres in the mouse.

Inbred, male 129/Re mice were maintained on a low plane of nutrition for a period of 21 days. After this time they were sacrificed and the following five muscles were examined for total fibre number and fibre diameter distributions, anterior tibialis, biceps brachii, extensor digitorum longus, soleus and sternomastoideus. Changes in body weight and muscle weight were also recorded. The low plane of nutrition resulted in a significant body weight loss (30%) and variously decreased muscle weights. The ratios, muscle weight: body weight, however, were higher in the experimental mice. The total fibre numbers of the muscles were not affected by the plane of nutrition. The mean fibre diameters of all the muscles, except the soleus, were lower in the experimental mice. These lower values were brought about by a decrease in the proportions of fibres of large diameter and not by the reduction in diameter of all the fibres. It was concluded that a low plane of nutrition caused fat deposits to be depleted, thereby reducing the body weight and the work-load of the phasic muscles, i.e., muscles bringing about body movements. This enabled the muscles to be effective at a smaller size. The level of muscle growth was adjusted at the individual fibre level.