Miracle-dz/UniFAR-FTUs huggingface dataset:
Which image types do universities tweet?

Universities use social media to attract prospective staff, students, and funding; to engage with current students; and to support teaching and learning. Images on social media are becoming particularly dominant, and whilst Twitter is not primarily an image-based social media service, nonetheless 36 percent of links shared on Twitter point to an image. This research paper compares the types of images that universities post on Twitter to the results of previous research that has investigated the types of images that universities post on Instagram, in order to better understand how universities are using the two services for image sharing.The most popular type of image tweeted by universities was showcasing (61 percent), followed by humanizing images (20.9 percent). The dominance of showcasing images on Twitter fits with the notion of Twitter as an information source rather than a networking source, with it predominantly being used as a means of one-way communication with current students to broadcast university-specific information, rather than for attracting prospective staff, students, and funding, or to support teaching and learning.
SPEICHER: Securing LSM-based Key-Value Stores using Shielded Execution

We introduce SPEICHER, a secure storage system that not only provides strong confidentiality and integrity properties, but also ensures data freshness to protect against rollback/forking attacks. SPEICHER exports a Key-Value (KV) interface backed by Log-Structured Merge Tree (LSM) for supporting secure data storage and query operations. SPEICHER enforces these security properties on an untrusted host by leveraging shielded execution based on a hardware-assisted trusted execution environment (TEE)-specifically, Intel SGX. However, the design of SPEICHER extends the trust in shielded execution beyond the secure SGX enclave memory region to ensure that the security properties are also preserved in the stateful (or non-volatile) setting of an untrusted storage medium, including system crash, reboot, or migration. More specifically, we have designed an authenticated and confidentiality-preserving LSM data structure. We have further hardened the LSM data structure to ensure data freshness by designing asynchronous trusted counters. Lastly, we designed a direct I/O library for shielded execution based on Intel SPDK to overcome the I/O bottlenecks in the SGX enclave. We have implemented SPEICHER as a fully-functional storage system by extending RocksDB, and evaluated its performance using the RocksDB benchmark. Our experimental evaluation shows that SPEICHER incurs reasonable overheads for providing strong security guarantees, while keeping the trusted computing base (TCB) small.
Treatment of Peri-Implantitis—Electrolytic Cleaning Versus Mechanical and Electrolytic Cleaning—A Randomized Controlled Clinical Trial—Six-Month Results

Objectives: The present randomized clinical trial assesses the six-month outcomes following surgical regenerative therapy of periimplantitis lesions using either an electrolytic method (EC) to remove biofilms or a combination of powder spray and electrolytic method (PEC). Materials and Methods: 24 patients with 24 implants suffering from peri-implantitis with any type of bone defect were randomly treated by EC or PEC. Bone defects were augmented with a mixture of natural bone mineral and autogenous bone and left for submerged healing. The distance from implant shoulder to bone was assessed at six defined points at baseline (T0) and after six months at uncovering surgery (T1) by periodontal probe and standardized x-rays. Results: One implant had to be removed at T1 because of reinfection and other obstacles. None of the other implants showed signs of inflammation. Bone gain was 2.71 ± 1.70 mm for EC and 2.81 ± 2.15 mm for PEC. No statistically significant difference between EC and PEC was detected. Significant clinical bone fill was observed for all 24 implants. Complete regeneration of bone was achieved in 12 implants. Defect morphology impacted the amount of regeneration. Conclusion: EC needs no further mechanical cleaning by powder spray. Complete re-osseointegration in peri-implantitis cases is possible.
Mesocorticolimbic Pathways Encode Cue-Based Expectancy Effects on Pain

Expectation interacting with nociceptive input can shape the perception of pain. It has been suggested that reward-related expectations are associated with the activation of the ventral tegmental area (VTA), which projects to the striatum (e.g., nucleus accumbens [NAc]) and prefrontal cortex (e.g., rostral anterior cingulate cortex [rACC]). However, the role of these projection pathways in encoding expectancy effects on pain remains unclear. In this study, we leveraged a visual cue conditioning paradigm with a long pain anticipation period and collected magnetic resonance imaging (MRI) data from 30 healthy human subjects (14 females). At the within-subject level, whole-brain functional connectivity (FC) analyses showed that the mesocortical pathway (VTA-rACC FC) and the mesolimbic pathway (VTA-NAc FC) were enhanced with positive expectation but inhibited with negative expectation during pain anticipation period. Mediation analyses revealed that cue-based expectancy effects on pain were mainly mediated by the VTA-NAc FC, and structural equation modeling showed that VTA-based FC influenced pain perception by modulating pain-evoked brain responses. At the between-subject level, multivariate pattern analyses demonstrated that gray matter volumes in the VTA, NAc, and rACC were able to predict the magnitudes of conditioned pain responses associated with positive and/or negative expectations across subjects. Our results therefore advance the current understanding of how the reward system is linked to the interaction between expectation and pain. Furthermore, they provide precise functional and structural information on mesocorticolimibic pathways that encode within-subject and between-subject variability of expectancy effects on pain. SIGNIFICANCE STATEMENT Studies have suggested that reward-related expectation is associated with the activation of the VTA, which projects to the striatum and prefrontal cortex. However, the role of these projection pathways in encoding expectancy effects on pain remains unclear. Using multimodality MRI and a visual cue conditioning paradigm, we found that the functional connectivity and gray matter volumes in key regions (the VTA, NAc, and rostral ACC) within the mesocorticolimbic pathways encoded expectancy effects on pain. Our results advance the current understanding of how the reward system is linked to the interaction between expectation and pain, and provide precise functional and structural information on mesocorticolimbic pathways that encode expectancy effects on pain.
Impact of Referral Center Pathology Review on Diagnosis and Management of Patients With Appendiceal Neoplasms.

CONTEXT. — Data regarding the clinical impact of subspecialist pathology review of appendiceal neoplasms are limited. OBJECTIVE. — To determine whether pathology review by gastrointestinal pathologists at a tertiary-care referral center resulted in significant changes in the diagnosis and clinical management of appendiceal neoplastic lesions. DESIGN. — We conducted a retrospective review of all patients with an initial diagnosis of appendiceal neoplasm referred to a tertiary-care referral center in Ontario, Canada, from 2010-2016. The discordance rate between original and review pathology reports, the nature of discordances, and the impact of any discordance on patient management were recorded. RESULTS. — A total of 145 patients with appendiceal lesions were identified (low-grade mucinous appendiceal neoplasm [n = 79], invasive mucinous adenocarcinoma [n = 12], "colorectal type" adenocarcinoma [n = 12], goblet cell carcinoid and adenocarcinomas ex goblet cell carcinoid [n = 24], and other lesions/neoplasms [n = 20]). One or more changes in diagnoses were found in 36 of 145 cases (24.8%), with changes within the same category of interpretation (n = 10), stage (n = 7), grade (n = 6), and categoric interpretation (n = 5) being the most common. In 10 of 36 patients (28%), the diagnostic change led to a significant change in management, including recommendation for additional surveillance, systemic chemotherapy, additional surgery, or discontinuation of surveillance. CONCLUSIONS. — Subspecialist pathology review of appendiceal neoplastic lesions led to a change in diagnosis in 36 of 145 cases (24.8%), of which nearly 30% (10 of 36 cases) led to a change in clinical management. The overall rate of clinically significant discordances was 7% (10 of 145). Our findings suggest that subspecialist pathology review of appendiceal neoplasms referred to specialized centers is justified.
Testing the Validity of an Internal Power Theory of Interpersonal Violence

The assertion that the motive behind battering is “power and control” is commonly accepted. Indeed, the most commonly cited “theory” behind Batterer Intervention Programs, a primary criminal justice system response to domestic violence, is that domestic violence offenders are motivated by their need to obtain “power and control. ” However, this theory has not been fully developed or empirically tested. Researchers have argued for the need to turn attention back to developing better theoretical models with clear conceptualizations and operationalizations of the power construct. Wagers articulated such a theory and introduced a “super construct” called internal power. This article seeks to further develop and empirically test Wagers’s theory. Confirmatory factor analysis is used to examine the viability of the internal power construct, and structural equation modeling is used to test the relationship between the internal power factor and self-reported interpersonal abusive behaviors. Findings indicate internal power is a viable construct that warrants further exploration and offer preliminary support for internal power theory as an explanation of intimate partner violence.
Describing adverse events in medical inpatients using the Global Trigger Tool.

AIMS The purpose of the study was to describe the type, prevalence, severity and preventability of adverse events (AEs) that affected hospitalised medical patients. We used the previously developed and validated Global Trigger Tool from the Institute for Healthcare Improvement. METHODS Using an adapted version of the Global Trigger Tool, we conducted a retrospective chart review of adult patients hospitalised in five medical wards at a university hospital in Switzerland. We reviewed a random sample of 20 patients’ charts for a total study period of 12 months (September 2016 to August 2017). Two trained nurses searched independently for triggers and possible AEs. All AEs were further validated by a senior physician. The number of triggers and AEs detected, as well as the severity and preventability of each, was assessed and analysed using descriptive statistics. RESULTS From a sample of 240 patient charts, we identified 1371 triggers and 336 AEs in 144 (60%) inpatients. This translates to an AE rate of 95.7 AEs per 1000 patient days. Most AEs (86.1%) caused temporary harm to the patient and required an intervention and/or prolonged hospitalisation. The estimated preventability of the in-hospital AEs was 29%. Healthcare-associated infections (25.8%) and neurological reactions (22.9%) were the most frequent AE types. CONCLUSION We found that about two thirds of patients suffered from AEs with harm during hospitalisation. It is common knowledge that AEs occur in hospitals and that they have potentially harmful consequences for patients, as well as a strong economic impact. However, to adequately prioritise patient safety interventions, it is essential to explore the nature, prevalence, severity and preventability of AEs. This is not only beneficial for the patients, but also cost effective in terms of shorter hospital stays.
Beyond clinical trials: social outcomes of structured stakeholder engagement in biomedical HIV prevention trials in China

Abstract Stakeholder engagement is increasingly recognised and institutionalised as an essential component of HIV-related biomedical research. However, we know little about stakeholder engagement’s social outcomes, such as its influence on the community it engages with, in authoritarian regimes and beyond high-income countries. This study evaluates a multi-site structured stakeholder engagement programme conducted in parallel with two HIV prevention studies among men who have sex with men in China. We conducted a one-month ethnographic study and 41 semi-structured interviews with participants of a structured stakeholder engagement programme in six Chinese cities. We found that the structured stakeholder engagement programme offered community stakeholders additional and flexible funding, networking opportunities, increased clinical research literacy, and strengthened their connections with the community. However, the structured stakeholder programme generated unintended consequences in some cases. It caused community stakeholders to expend their social capital, introduced moral conflicts and created tension between stakeholders’ ‘community representative’ and ‘research assistant’ identities. Our findings suggest that despite these unintended consequences, structured stakeholder engagement could effectively mitigate negative outcomes generated by such engagement if such programmes are more sensitive and responsive to the broader socio-political structure in which trials are embedded.
Medial femoral condyle free flap in combination with paramedian forehead flap for total/subtotal nasal reconstruction: Level of evidence: IV (therapeutic studies)

The nose is a functionally complex organ with also a critical role in aesthetics. For reconstruction of full thickness nasal defects, multiple stages are needed and there is risk for resorption resulting in residual deformity. The aim of this report was to develop and evaluate a new method for full thickness total/subtotal nose reconstruction using the medial femoral condyle free flap (MFCFF) in combination with a paramedian forehead flap.
Effect of Low-level Laser Therapy on Orthodontic Tooth Movement

Introduction: Prolonged orthodontic treatment duration is detrimental in terms of increased incidence of caries, root resorption, and reduced patient compliance. The aim of this randomized, clinical trial was to evaluate the effect of low-level laser therapy (LLLT) on the rate of orthodontic tooth movement (OTM) and pain control. Materials and Methods: This single-blind study included twenty participants requiring extraction of all first premolars. Randomly selected split-mouth design was used. One side was irradiated with 810 nm diode laser (dose of 5.0 J/cm2) at 10 points for 10 s. Irradiation was performed just after loading canine retraction forces and on days 3rd and 7th. Every 21st day, the force level of coil spring was adjusted, and LLLT protocol was repeated till retraction was complete. Measurements were recorded on study models to evaluate the rate of retraction. Results: Significant increase in OTM was observed on the side exposed to LLLT when compared to control side (P < 0.05). Statistically significant difference in pain perception was observed during first 2 days only between lased site and control site (P < 0.05). Conclusion: LLLT is a reliable tool for enhancing OTM and is effective in relieving pain at parameter settings and protocol used in this study.
Association between p53 Expression and Amount of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer

Background Most triple-negative breast cancers (TNBCs) have a high histologic grade, are associated with high endoplasmic stress, and possess a high frequency of TP53 mutations. TP53 missense mutations lead to the production of mutant p53 protein and usually show high levels of p53 protein expression. Tumor-infiltrating lymphocytes (TILs) accumulate as part of the anti-tumor immune response and have a strong prognostic and predictive significance in TNBC. We aimed to elucidate the association between p53 expression and the amount of TILs in TNBC. Methods In 678 TNBC patients, we evaluated TIL levels and expression of endoplasmic stress molecules. Immunohistochemical examination of p53 protein expression was categorized into three groups: no, low, and high expression. Results No, low, and high p53 expression was identified in 44.1% (n = 299), 20.1% (n = 136), and 35.8% (n = 243) of patients, respectively. Patients with high p53 expression showed high histologic grade (p < .001), high TIL levels (p = .009), and high expression of endoplasmic reticulum stress-associated molecules (p-eIF2a, p = .013; XBP1, p = .007), compared to patients with low p53 expression. There was no significant difference in disease-free (p = .406) or overall survival rates (p = .444) among the three p53 expression groups. Conclusions High p53 expression is associated with increased expression of endoplasmic reticulum stress molecules and TIL influx.
A systematic and methodological review of attentional biases in eating disorders: Food, body, and perfectionism

The current systematic and methodological review aimed to critically review existing literature utilizing implicit processing, or automatic approach‐ and/or avoidance‐related attentional biases between eating disorder (ED) and nonclinical samples, which (a) highlights how psychophysiological methods advance knowledge of ED implicit bias; (b) explains how findings fit into transdiagnostic versus disorder‐specific ED frameworks; and (c) suggests how research can address perfectionism‐related ED biases.
Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development

Studies report inconsistent findings on the relationship between ASD and breastfeeding. We explored associations between ASD and breastfeeding initiation (yes/no) and duration (months categorized in tertiles) in the Study to Explore Early Development, a community‐based case–control study in six sites in the Unites States. We adjusted for various child and mother demographic and pregnancy factors. Breastfeeding initiation was reported in 85.7% of mothers of children with ASD and 90.6% of mothers of controls. After adjustment, we found no significant difference in breastfeeding initiation (adjusted odds‐ratio [aOR]: 0.88 and 95% confidence interval (CI) 0.60–1.28). However, mothers of children with ASD were less likely to report duration of breastfeeding in the high (≥12 months) versus low tertile (<6 months) (aOR and 95% CI: 0.61 [0.45–0.84]) or the middle (6–<12 months) versus low tertile (0.72: 0.54–0.98). The association of ASD and breastfeeding duration was slightly attenuated when the presence of the broader autism phenotype (BAP) in the mother was accounted for, but still remained for the highest tertile. This association does not appear to be totally explained by maternal BAP. We were unable to distinguish whether the difference in duration was due to difficulties breastfeeding children who later develop ASD, other factors not adjusted in our study, or greater ASD risk resulting from shorter breastfeeding duration. Longitudinal studies that compare reasons why mothers stop breastfeeding between ASD and controls and establish a temporal relation between ASD and breastfeeding are needed. Future studies should also evaluate interactions between ASD risk genes and breastfeeding. Autism Research 2019, 12: 816–829. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.
Direct observation of changing NOx lifetime in North American cities

A shifting lifetime for NOx Nitrogen oxides (NOx) have a central role in controlling air quality, so designing effective strategies to combat air pollution, especially by ozone and particulate matter, depends on knowing their atmospheric abundances. Those abundances depend not only on NOx production rates but also on their lifetimes. Laughner and Cohen report that NOx lifetimes can be measured directly from satellite observations of nitrogen dioxide. They used data on 49 North American cities to show how NOx lifetimes there changed between 2005 and 2014. Accounting for this change in lifetime should help to reconcile conflicting trends between bottom-up and top-down emissions estimates. Science, this issue p. 723 The lifetimes of atmospheric nitrogen oxides can be determined by remote satellite measurements. NOx lifetime relates nonlinearly to its own concentration; therefore, by observing how NOx lifetime changes with changes in its concentration, inferences can be made about the dominant chemistry occurring in an urban plume. We used satellite observations of NO2 from a new high-resolution product to show that NOx lifetime in approximately 30 North American cities has changed between 2005 and 2014 in a manner consistent with our understanding of NOx chemistry.
Targeted PMP22 TATA-box editing by CRISPR/Cas9 reduces demyelinating neuropathy of Charcot-Marie-Tooth disease type 1A in mice

Abstract Charcot-Marie-Tooth 1A (CMT1A) is the most common inherited neuropathy without a known therapy, which is caused by a 1.4 Mb duplication on human chromosome 17, which includes the gene encoding the peripheral myelin protein of 22 kDa (PMP22). Overexpressed PMP22 protein from its gene duplication is thought to cause demyelination and subsequently axonal degeneration in the peripheral nervous system (PNS). Here, we targeted TATA-box of human PMP22 promoter to normalize overexpressed PMP22 level in C22 mice, a mouse model of CMT1A harboring multiple copies of human PMP22. Direct local intraneural delivery of CRISPR/Cas9 designed to target TATA-box of PMP22 before the onset of disease, downregulates gene expression of PMP22 and preserves both myelin and axons. Notably, the same approach was effective in partial rescue of demyelination even after the onset of disease. Collectively, our data present a proof-of-concept that CRISPR/Cas9-mediated targeting of TATA-box can be utilized to treat CMT1A.
Adaptive Calibration of Electrode Array Shifts Enables Robust Myoelectric Control

Objective: The objective of this work is to develop a novel method for adaptive calibration of the electrode array shifts toward achieving robust myoelectric pattern-recognition control. Methods: This work is inspired by the idea of image object detection when high-density surface electromyogram signals recorded from a two-dimensional electrode array carry rich spatial information and can serve as a muscular activation image. A convolutional neural network involving transfer learning (from a network for image recognition) is used to learn muscular activity patterns at an original/baseline position of an electrode array. The shift of an electrode array can be estimated by identifying and matching partially overlapped regions between the training images of muscular activation and the testing images at any other position, in an unsupervised manner. Given the calibration of an electrode array shift, the identification of muscular activity patterns is implemented accordingly. The performance of the proposed method was evaluated with data recorded by a 10 × 10 electrode array placed over the forearm extensors of 10 subjects performing 6 wrist and finger extension tasks. Results: The proposed method achieved high task classification accuracies around 95% and outperformed five traditional methods under conditions with multiple designated shifts in offline experiments and a random shift in online testing. Conclusion: The proposed method is demonstrated to be a promising solution for the automatic and adaptive calibration of electrode array shifts. Significance: This work will enhance the robustness of myoelectric control systems.