Miracle-dz/UniFAR-FTUs huggingface dataset:
Endorsement of models describing sexual response of men and women with a sexual partner: an online survey in a population sample of Danish adults ages 20-65 years.

INTRODUCTION Several models have been used to describe men's and women's sexual responses. These models have been conceptualized as linear or circular models. The circular models were proposed to describe women's sexual function best. AIM This study aims to determine whether men and women thought that current theoretical models of sexual responses accurately reflected their own sexual experience and to what extent this was influenced by sexual dysfunction. METHODS A cross-sectional study of a large, broadly sampled, nonclinical population, cohort of Danish men and women. The Female Sexual Function Index, Female Sexual Distress Scale, and the International Index of Erectile Function were used to describe sexual function. Also, participants completed questionnaires with written descriptions of different sexual responses to describe their most experienced sexual response. MAIN OUTCOME MEASURE For women, we measured desire, arousal, lubrication, orgasm, sexual satisfaction, pain during sexual activity, sexual distress, and satisfaction with sexual life. For men, we measured erectile function, orgasm, desire, intercourse satisfaction, overall satisfaction, and satisfaction with sexual life. RESULTS A total of 499 men and 573 women participated. We only analyzed responses from sexually active participants with a partner (401 men and 429 women). The majority of men endorsed the Masters & Johnson model (48.5%) or the Kaplan model (38.3%); only 5.4% endorsed the Basson model, and 7.3% endorsed none of the models. Among women, 34% endorsed the Kaplan model, 28% the Masters & Johnson model, 25.6% the Basson model, and 12.5% none of the models. Among women, sexual dysfunction and distress were significantly (P = 0.01) related to endorsement of the Basson model or none of the models. Among men, erectile dysfunction and dissatisfaction with sexual life were significantly related to endorsement of the Basson model or none of the models (P = 0.01). CONCLUSIONS No single model of sexual response could describe men's and women's sexual responses. The majority of men and women with no sexual dysfunction that were satisfied with their sexual life endorsed the linear models.
PROTECTIVE EFFECT OF Ailanthus excelsa ROXB IN MYOCARDIAL INFARCTION POST MESENCHYMAL STEM CELL TRANSPLANTATION: STUDY IN CHRONIC ISCHEMIC RAT MODEL

Background: Thia study evaluates the effects of Ailanthus excelsa Roxb methanolic extract (AER-ME) in rats induced with Myocardial Infarction (MI) followed by transplantation of MSCs. Material and Methods: Rats were induced with MI by ligation technique of left coronary artery. The sham-operated the control and AER-ME treated group of rats received transplantation of PKH-26 and marked MSCs followed by normal saline and AER-ME treatment (200mg/kg/day of AER-ME extract) respectively for 30 days. Parameters such as cardiac function, inflammation, oxidative stress, apoptosis and differentiation of MSCs (angiogenesis) were evaluated. Histological studies of infracted myocardium reveled anti-inflammatory activity of AER-ME treatment. Result and Discussion: Oxidative stress parameters revealed decrease in levels of malondialdehyde (MDA) and increase in superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSHpx) activity significantly indicating antioxidant activity of the extract. There was a reduction in cell death rate of treated rats due to the decrease in apoptotic index with prolongation of MI when compared to both control and sham-operated groups. The expression of Fas protein was parallel to apoptotic index. The vascular density increased significantly in extract treated group. The treatment showed improved cardiac activity with decreased left ventricular end diastolic (LVEDP) and arterial pressure while the left ventricular end systolic pressure (LVEP) and dp/dtmax increased significantly when compared to both control and sham-operated groups respectively showing the protective effect of the extract as necessitated by the transplantation of MSCs. The study marked the protective outcomes of AER-ME treatment for MSCs in microenvironment of infracted myocardium by improving their viability and increasing differentiation into cardiomyocytes.
Long-term nitrate treatment increases cardiac events in patients with healed myocardial infarction. Secondary Prevention Group.

BACKGROUND Nitrates dilate coronary arteries, ameliorate myocardial ischemia, minimize left ventricular remodeling, and reduce mortality in patients with acute myocardial infarction. However, the effects of long-term treatment with nitrates on cardiac events in patients with healed myocardial infarction are not known. METHODS AND RESULTS A total of 1,002 patients with healed myocardial infarction (789 male and 213 female) were randomly divided into 2 groups: treatment with nitrates or nontreatment. The mean observation period was 18.0 +/- 19.9 months. Primary end points were nonfatal and fatal recurrent myocardial infarction, death from congestive heart failure, and sudden death. Baseline characteristics of the 2 groups were also compared to determine any effects on outcome. Among the 621 cases treated with nitrates, 41 cases (6.6%) experienced cardiac events during the observation period, whereas only 12 of the 381 cases that were not treated with nitrates (3.1%) had cardiac events. This difference was statistically significant (p < 0.05; odds ratio 2.17; 95% confidence interval 1.13-4.19). There were no differences in the incidence of noncardiac death or being lost to follow-up between the 2 groups. Although the precise mechanism of this increase in the occurrence of cardiac events by long-term treatment with nitrates is not clear, nitrate tolerance with possible rebound and neurohormonal effects may be involved. CONCLUSION Long-term treatment with nitrates increased cardiac events in patients with healed myocardial infarction.
Low Observable Targets Detection by Joint Fractal Properties of Sea Clutter: An Experimental Study of IPIX OHGR Datasets

We exploit the joint fractal properties of sea clutter extracted from detrended fluctuation analysis (DFA) for targets detection. We find that two specific fractal statistics, i.e., the intercept at the crucial scale and the Hurst exponent of optimal scales provide valuable information for targets detection. The first statistic measures the discrepancy between sea clutter and low observable targets at the crucial fractal scale, and the second one evaluates the average fractal difference within the optimal multi-scales. A target detection method integrating these two statistics is proposed, which is validated by real-life IPIX radar datasets. We find that this joint fractal detection approach achieves more accurate results for low observable targets detection.
Diversity of antifungal and plant‐associated Serratia plymuthica strains

A total of 21 plant‐associated Serratia plymuthica strains were characterized phenotypically by their nutritional patterns, susceptibility to antibiotics, antifungal and haemolytic properties, and genotypically by denaturing gradient gel electrophoresis (DGGE) of PCR‐amplified 16S rDNA, PCR fingerprints using BOX primers (BOX‐PCR) and pulsed‐field gel electrophoresis (PFGE) after digestion with SpeI.
Choice of Flap and Incidence of Free Flap Success

&NA; A review of 854 consecutive free flaps was performed to determine whether the choice of flap used for the reconstruction influenced the probability of a successful outcome. Flaps were grouped into nine categories: rectus abdominis, free transverse rectus abdominis myocutancous, radial forearm, jejunum, latissimus dorsi, fibula, scapula, iliac crest, and other. There were significant differences among the success rates of different flaps (p < 0.0001). Rectus abdominis‐based flaps used for breast or head and neck reconstruction had lower failure rates (0.9 percent) than did non‐rectus abdominis Haps (6.6 percent; p < 0.0001). Flaps requiring vein grafts had a higher rate of flap loss (18.4 percent) than did flaps that did not require vein grafts (2.9 percent; p < 0.0001). There was a strong trend favoring survival of flaps without a bone component (compared with osteocutaneous flaps), and a weaker trend favoring survival of flaps in nonobese patients (compared with flaps in obese patients). Smoking, age. and previous irradiation had no significant effect on flap failure rales. Surgeons should consider the flap success rate as one (but not necessarily the most important) factor in choosing the best reconstruction for any individual patient.
Treatment received by alcohol‐dependent suicide attempters

The purpose of this study was to examine the clinical features of alcohol‐dependent suicide attempters and the treatment they received before and after the index attempt. A total of 47 subjects with current DSM‐III‐R alcohol dependence were identified from a systematic sample of 114 suicide attempters in Helsinki. All of them were comprehensively interviewed after the attempt, and the treatment they had received was established from psychiatric and other health‐care records and follow‐up interviews. Most had a history of psychiatric (83%) or substance abuse (83%) treatment. During the final month before the attempt, half of the subjects (51 %)) had been treated by health care services; 11% had received disulfiram‐treatment and 6% had received psychotherapy. Subjects complied with recommended aftercare more often when they had been actively referred. After 1 month, 64% were being treated by health care services. However, only 14% were receiving disulfiram‐treatment and 9% were receiving psychotherapy. These findings suggest that the quality and activity of treatment offered to suicide attempters with alcohol dependence should be improved.
Meta-analysis of methods used to assess implant stability.

PURPOSE To evaluate correlations between Periotest, cutting torque or insertion torque, and/or the reverse torque test with resonance frequency analysis measurements. MATERIALS AND METHODS The combined search terms dental implant, primary stability, resonance frequency analysis, removal torque, vibration analysis, torque, Periotest, cutting torque, and insertion torque and specific inclusion and exclusion criteria were used to retrieve eligible articles published between 1998 and 2008 (up to April 1) from PubMed, EMBASE, OVID, The Cochrane Library databases, and 10 journals by hand-searching. The pooled P value was calculated with the Fisher method. The correlation coefficients (r) were combined using fixed and random effect models. Heterogeneity of the studies was tested by performing the homogeneity test. RESULTS Fifty articles were identified, but 3 studies were excluded because of limitations in study design. Studies that fulfilled the inclusion criteria fell into a variety of categories (11 human cadaver, 16 clinical, 15 animal, and 5 in vitro studies). Assessment of P values revealed that correlation between cutting torque or insertion torque and resonance frequency analysis was significant (6 studies; P = .0022). Correlation between Periotest and cutting torque or insertion torque was significant (1 study; P = .015), and correlations between resonance frequency analysis and reverse torque test values (1 study; P = .319; r = 0.405) and Periotest and resonance frequency analysis (P = .28) were insignificant. Nine articles provided r values, and cutting torque or insertion torque and resonance frequency analysis showed a statistically significant and direct relationship of 55.4% (P = .000). One study provided an r value of -0.149. A statistically significant and direct relationship of 87.6% was found between cutting torque or insertion torque and reverse torque (2 studies; P = .000). CONCLUSION This meta-analysis of 47 studies showed a statistically significant correlation between cutting torque or insertion torque and resonance frequency analysis.
Endoscopic Ostium Assessment Following Endonasal Dacryocystorhinostomy with Mitomycin C Application

Aim: The aim of the study is to visualize the patency and measure the ostium size at the end of Endonasal DCR with mitomycin C (MMC) versus control and to assess the role of Mitomycin C in maintaining patency of nasolacrimal drainage system. Design: Prospective randomized controlled study Participants: Sixty patients who consented for this study was subjected to endonasal DCR and randomised into 2 groups (30 cases with mitomycin – C and 30 cases without MMC). Methods: Mitomycin-C 0.2mg/ml was applied intra-operatively for 5mins to the ostium site at the end of endonasal DCR in the MMC group. Results: In the mitomycin C group, 97% (29/30) of the ostium was found to be patent while in the control group 87% (26/30) were found to be patent. It was found that there was statistically significant difference in the osteotomy surface area between the MMC group and control group (p < 0.001). Both groups had a mean follow-up of 24-36 months. No complications were associated with use of Mitomycin-C. Conclusion: Intra-operative use of MitomycinC in endonasal DCR is safe and effective in maintaining the ostium size and thereby increasing the success rate.
Plasma Sex Hormones and Aromatase Activity in Tissues of Patients with Systemic Lupus Erythematosus

Clinical observations and experimental data suggest that sex hormones influence the develop ment of systemic lupus erythematosus (SLE). An imbalance between androgen and estrogen plasma levels may suggest an abnormality in the aromatase activity involved in estradiol syn thesis. Aromatase activity in skin and subcutaneous tissue and plasma sex-hormone levels (testosterone, androstenedione, estrone, estradiol, dehydrosterone sulfate, cortisol) were measured in 15 SLE patients (nine female, six male) who had never received corticosteroid treatment and in eight (four female, four male) healthy control subjects. There was a tendency toward an increase in aromatase activity in SLE patients when compared to control subjects. Among SLE patients the aromatase activity varied inversely with disease activity. Patients with SLE had decreased androgen and increased estrogen levels. Aromatase activity in SLE patients had significant direct correlation with estrogen levels. These data suggest that abnormal regulation of aromatase activity may partially explain the abnormalities of estrogen synthesis in SLE.
Human Enteric Coronaviruses: Further Characterization and Immunoblotting of Viral Proteins

1. Myer EA, Jarroll EL. Giardiasis. Am J Epidemiol 1980;111:1-12 2. Keystone JS, Krajden S, Warren MR. Person-to-person transmission of Giardia lamblia in day-care nurseries. Can Med Assoc J 1978;119:241-8 3. Jarroll EL, Bingham AK, Meyer EA. Effect of chlorine on Giardia lamblia cyst viability. Appl Environ Microbiol 1981;41:483-7 4. Owen RL. The immune response in clinical and experimental giardiasis. Trans R Soc Trop Med Hyg 1980;74:443-5 5. Smith PD, Gillin FD, Brown WR, Nash TE. IgG antibody to Giardia lamblia detected by enzyme-linked immunosorbent assay. Gastroenterology 1981;80:1476-80 6. Myer EA. Giardia lamblia isolation and axenic cultivation. Exp Parasitol 1976;39:101-5 7. Smith PD, Gillin FD, Kausha Na, Nash TE. Antigenic analysis of Giardia lamblia from Afganistan, Puerto Rico, Ecuador, and Oregon. Infect Immun 1982;36:714-9 Concise Communications
Inhibition of Interleukin-12 p40 Transcription and NF-κB Activation by Nitric Oxide in Murine Macrophages and Dendritic Cells*

Nitric oxide (NO), an important effector molecule of the innate immune system, can also regulate adaptive immunity. In this study, the molecular effects of NO on the toll-like receptor signaling pathway were determined using interleukin-12 (IL-12) as an immunologically relevant target gene. The principal conclusion of these experiments is that NO inhibits IL-1 receptor-associated kinase (IRAK) activity and attenuates the molecular interaction between tumor necrosis factor receptor-associated factor-6 and IRAK. As a consequence, the NO donor S-nitroso-N-acetylpenicillamine (SNAP) inhibits lipopolysaccharide (LPS)-induced IL-12 p40 mRNA expression, protein production, and promoter activity in murine macrophages, dendritic cells, and the murine macrophage cell line RAW 264.7. Splenocytes from inducible nitric-oxide synthase-deficient mice demonstrate markedly increased IL-12 p40 protein and mRNA expression compared with wild type splenocytes. The inhibitory action of NO on IL-12 p40 is independent of the cytokine IL-10. The effects of NO can be directly attributed to inhibition of NF-κB activation through IRAK-dependent pathways. Accordingly, SNAP strongly reduces LPS-induced NF-κB DNA binding to the p40 promoter and inhibits LPS-induced IκB phosphorylation. Similarly, NO attenuates IL-1β-induced NF-κB activation. These experiments provide another example of how an innate immune molecule may have a profound effect on adaptive immunity.
PREDICTORS OF FACEBOOK ADDICTION AMONG YOUTH: A STRUCTURAL EQUATION MODELING (SEM)

With the popularity of Facebook, more and more youth extensively adopt Facebook for different motives. They are spending a plenty of time daily on surfing the site, which may be an indication of addiction. The current study investigates the predictors of Facebook addiction among youth from the uses and Gratifications theory perspective. Using online survey, the data was obtained from 309 youth from a Sub-Saharan African country. Data was analyzed using AMOS version 18 and SPSS version 17. The results of the structural equation modeling suggested that social interaction (s= . 21, p
Characterization of emm types and superantigens of Streptococcus pyogenes isolates from children during two sampling periods

SUMMARY The characteristics of 359 group A streptococcal (GAS) isolates collected from Chinese paediatric patients in two periods (1993–1994, 2005–2006) were studied. Isolates were assigned to emm types and assayed for eight superantigen (SAg) genes (speA, speC, speH, speI, speG, speJ, ssa, SMEZ). Types emm1 and emm12 were consistently the most prevalent during the two periods, while others varied in frequency. GAS isolates carrying six or more SAg genes increased from 46·53% (1993–1994) to 78·39% (2005–2006); ssa, speH and speJ genes (P<0·05) increased but speA declined (P<0·05). SAg gene profiles were closely associated with the emm type, but strains of the same emm type sometimes carried different SAg genes in the two periods. No significant difference in emm-type distribution and SAg gene profile was noted between isolates from different diseases. These data may contribute towards the development of a GAS vaccine in China.
A 22 year old man with acute genital oedema and a swollen ankle

A 22 year old man was referred to our outpatient department with a painless non-pruritic swelling of the genitals that had spontaneously developed in the course of a few hours. He had taken no medication in the past few months and denied having allergies. His medical history included intermittent “joint swellings,” which started at the age of 12. These swellings were sometimes preceded by a tingling sensation and usually resolved spontaneously within two days. Furthermore, at the age of 22 he was admitted to hospital with an episode of acute and severe abdominal pain for which no apparent cause was found. Physical examination showed scrotal and penile oedema (fig 1⇓), with no mucosal defects or skin abnormalities. He also had subtle swelling around the right ankle (fig 2⇓). His vital signs were within the normal range and his temperature was 36.8°C. Ultrasonography of the scrotum and penis showed extensive subcutaneous oedema but no other abnormalities. Screening laboratory analyses (blood and urine) were unremarkable. ### 1 What are the likely diagnosis and the differential diagnoses? #### Short answer The signs and symptoms and his medical history suggest a diagnosis of hereditary angio-oedema. The main differential diagnosis is Quincke’s oedema. Other differential diagnoses are idiopathic scrotal oedema, allergic reactions, drug reactions, and penile friction oedema. #### Long answer The main diagnosis to consider in this case is hereditary angio-oedema. This is a rare autosomal dominant disease caused by mutations in the gene encoding the broad spectrum protease inhibitor C1 esterase inhibitor (C1INH), which leads to reduced plasma concentrations of functional C1INH.1 This enzyme is the primary inhibitor of the complement proteases C1r and C1s as well as the contact system proteases, activated Hageman factor (coagulation factors XIIa and XIIf), …
Assessing Protection from Suicidal Risk: Psychometric Properties of the Suicide Resilience Inventory

This study investigated psychometric properties of the Suicide Resilience Inventory-25 (SRI-25) in a diverse sample of 239 college students. Participants completed the SRI-25, Beck Hopelessness Scale (BHS), Suicidal Ideation Questionnaire, and the Multidimensional Scale of Perceived Social Support (MSPSS). Confirmatory factor analysis supported the 3 dimensions described by SRI-25 authors (A. Osman et al., 2004): internal protective, emotional stability, and external protective. Correlations with the BHS (r = − .68) and SIQ (r = − .67) supported the scale's validity, although the external protective subscale and MSPSS were only moderately correlated (r = .47). Overall, the SRI-25's reliability and validity support its use in suicide research. Implications for exploring young adults' resilience in the face of suicidal thoughts via clinical interview or administration of the SRI-25 are discussed as they create an opportunity to potentially infuse hope, tap into strengths, and identify avenues for positive change.
Deletion in Open Reading Frame 49 of Varicella-Zoster Virus Reduces Virus Growth in Human Malignant Melanoma Cells but Not in Human Embryonic Fibroblasts

ABSTRACT The ORF49 gene product (ORF49p) of the varicella-zoster virus (VZV) is likely a myristylated tegument protein, and its homologs are conserved across the herpesvirus subfamilies. The UL11 gene of herpes simplex virus type 1 and of pseudorabies virus and the UL99 gene of human cytomegalovirus are the homologs of ORF49 and have been well characterized by using mutant viruses; however, little research on the VZV ORF49 gene has been reported. Here we report on VZV ORF49p expression, subcellular localization, and effect on viral spread in vitro. ORF49p was expressed during the late phase of infection and located in the juxtanuclear region of the cytoplasm, where it colocalized mainly with the trans-Golgi network-associated protein. ORF49p was incorporated into virions and showed a molecular mass of 13 kDa in VZV-infected cells and virions. To elucidate the role of the ORF49 gene, we constructed a mutant virus that lacked a functional ORF49. No differences in plaque size or cell-cell spread were observed in human embryonic fibroblast cells, MRC-5 cells, infected with the wild-type or the mutant virus. However, the mutant virus showed diminished cell-cell infection in a human malignant melanoma cell line, MeWo cells. Therefore, VZV ORF49p is important for virus growth in MeWo cells, but not in MRC-5 cells. VZV may use different mechanisms for virus growth in MeWo and MRC-5 cells. If so, understanding the role of ORF49p should help elucidate how VZV accomplishes cell-cell infections in different cell types.