Miracle-dz/UniFAR-FTUs huggingface dataset:
English Language Learners and the Classroom: Inclusive Strategies and Beliefs of Ontario Teachers

2 Acknowledgments 3 Chapter 1: Introduction 8 1.0 Research Context and Problem 8 1.1 Purpose of the Study 11 1.2 Research Questions 12 1.3 Background of Researcher 13 1.4 Overview 15 Chapter 2: Literature Review 16 2.0 Introduction to the Chapter 16 2.1 ESL Education and the Government 16 2.1.1 ESL Policies and Curriculum Documents 17 2.1.2 History of ESL Education 18 2.1.3 Funding 19 2.2 Perceptions and Attitudes towards English Language Learners 21 2.2.1 Teacher Attitudes 21 2.2.2 Student Attitudes 22 2.3 Teacher’s Professional Development 22 2.3. 1 Teacher Training 23 2.3. 2 ESL Infusion 23
Determination of corticotropin (ACTH) in human blood and urine by a modified oxycellulose method.

THE method of Sydnor and Sayers (1) for the determination of corticotropin (ACTH) in blood has been modified and shortened so that the entire procedure of concentrating corticotropin in an injectable volume can be completed within ten hours. With this new modification we have been able to inject the equivalent of 200 ml. of blood into a single test rat. The largest volume of blood which could be used by Sydnor and Sayers was 40 ml. ; and in normal subjects, corticotropin was undetectable in this amount (2, 3). By decreasing the amount of acetic acid mixed with blood and centrifuging the mixture before adding oxycellulose, we have succeeded in removing toxic material which precluded the injection of volumes larger than 40 ml. equivalent. The modification is based on the technic developed by Takahashi for the determination of MSH in blood (4). The oxycellulose technic has also been applied to urine, so that the equivalent of a 24-hour urine sample can be tested in a single rat.
Two faces of calcium activation after optic nerve trauma: life or death of retinal ganglion cells in vivo depends on calcium dynamics

Calcium elevations after neurotrauma are not only implicated in cell death but may contribute to adaptive plasticity. We now wished to resolve this contradiction by following calcium dynamics after optic nerve crush in vivo. Adult rats received no injury (n = 5), unilateral mild (n = 10) or moderate optic nerve crush (n = 10) (ONC), or axotomy (n = 5). Before surgery, retinal ganglion cells (RGCs) were retrogradely labelled with Oregon Green BAPTA‐dextran, a fluorescent calcium marker. Calcium‐related fluorescence intensity (FI) was repeatedly measured in individual RGCs in vivo using the in vivo confocal neuroimaging (ICON) method. Four different RGC types were found. Normal RGCs without FI change were found in sham rats and also in both ONC groups. RGCs with mild damage were seen only after mild ONC, showing an initial calcium depression of 26% at day 4 followed by a 169% increase 15 days after ONC. RGCs with moderate damage were found only after moderate ONC and showed calcium hypoactivation followed by a slower return toward baseline and a delayed calcium increase of 72% above baseline. Sixty to sixty‐five per cent of the RGCs in both ONC groups and all RGCs in the axotomy group died within 6 days following a fast and massive calcium increase of 316% with a concomitant 156% soma size increase. In conclusion rapid calcium elevation leads to cell death, while an initial calcium depression followed by a delayed and moderate calcium hyperactivation is associated with cell survival. We propose that immediate, massive calcium activation is maladaptive whereas delayed and moderate hyperactivation of surviving cells is adaptive. Implications for pharmacotherapy are discussed.
Why Middle East Studies Missed the Arab Spring

THE VAST majority of academic specialists on the Arab world were as surprised as everyone else by the upheavals that toppled two Arab leaders last winter and that now threaten several others. It was clear that Arab regimes were deeply unpopular and faced serious demographic, economic, and political problems. Yet many academics focused on explaining what they saw as the most interesting and anomalous aspect of Arab politics: the persistence of undemocratic rulers.
Technology, employment and the business cycle in post-transition countries of the EU

Abstract This article analyses the importance of technology and non-technology shocks in the business cycles of European Union post-transition countries. Different assumptions of New Keynesian and Real Business Cycle theory are tested. The results demonstrate that a non-technology shock is more important in explaining business cycles in post-transition countries, although a technology shock is not trivial. The technology shock cannot replicate basic business cycle facts observed in the data: it produces a low or negative correlation between employment and GDP, and a strong negative correlation between labour productivity and employment. Technology and non-technology GDP components are analysed in the transition and post-transition period. The results show a non-technology shock was the dominant source of business cycles both during and after the transition period.
Herb-partition moxibustion relieves chronic visceral hyperalgesia and 5-HT concentration in colon mucosa of rats

Abstract Objective: The aim of this study was to evaluate the effect of herb-partition moxibustion on rectal sensory thresholds and to analyse possible mechanism of herb-partition moxibustion in treating chronic visceral hypersensitivity rats. Methods: Herb-partition moxibustion was administered to chronic visceral hypersensitivity rats for 7 days (once daily). Two moxa cylinders were used for each point in one treatment. Chronic visceral hypersensitivity rats without herb-partition moxibustion and normal rats were chosen as the control groups. Detection of abdominal withdrawal reflex was performed during 30–90 minutes after the first treatment. After seven treatments, a segment of distal colon (5 cm in length) was harvested, and 5-hydroxytryptamine concentration in the colon tissue was detected by enzyme-linked immunosorbent assay. Results: Herb-partition moxibustion significantly depressed abnormally increased AWR scores from the rectus abdominis in response to colorectal distention stimulation at strengths of 40 and 60 mmHg. Herb-partition moxibustion decreased 5-hydroxytryptamine concentration in colon tissue of chronic visceral hypersensitivity rats. Conclusion: Herb-partition moxibustion enhances the pain threshold of chronic visceral hypersensitivity rats and restores normal sensitivity by 5-hydroxytryptamine concentration decreased in the colon tissue. However, whether herb-partition moxibustion could enhance the pain threshold of IBS patients or not is not concluded in this study because of only small sample rats experiment.
Managerial implications of rocking the floor by employees

Voice is a proactive self-expressive behaviour of employees which has various positive impacts and is a potential contribution towards organization effectiveness. Existing studies have highlighted a difference between two types of voice, promotive and prohibitive. Although both types of voice benefit the organization, prohibitive voice implies an inherent challenge. The study hypothesizes that a manager may take prohibitive voice as a challenging activity and may perceive employees with promotive voice as loyal ones and those with a prohibitive voice as threatening for the organization. Further it aims to examine the managers’ response towards voice in form of evaluation of performance and the mediating effect of managers’ perceived loyalty and threat on this judgement. To empirically test the proposed model, data were collected by employees and their supervisors working at various private servicing and manufacturing organizations through survey questionnaires. Results revealed that performance evaluation is negatively related with perceived loyalty and positively associated with perceived threat.
Lower Oil Prices and the U.S. Economy: Is This Time Different?

ABSTRACT:We explore the effect of the sharp and sustained decline after June 2014 in the global price of crude oil (and hence in the U.S. price of gasoline) on U.S. real GDP growth. Our analysis suggests that this decline produced a cumulative stimulus of about 0.9 percent of real GDP by raising private real consumption and non-oil-related business investment, and an additional stimulus of 0.04 percent, reflecting a shrinking petroleum trade deficit. This stimulative effect, however, has been largely offset by a large reduction in real investment by the oil sector. Hence, the net stimulus since June 2014 has been close to zero. We show that the U.S. economy’s response was not fundamentally different from that observed after the oil price decline of 1986. Then as now, the U.S. economy’s response is consistent with standard economic models of the transmission of oil price shocks. We find no evidence that frictions in reallocating capital and labor across sectors or increased uncertainty about the price of gasoline explain the sluggish response of U.S. real GDP growth. Nor do we find evidence of financial contagion, of spillovers from oil-related investment to non-oil-related investment, of an increase in household savings, or of households deleveraging.
Cyclic phosphatidic acid elicits neurotrophin‐like actions in embryonic hippocampal neurons

Cyclic phosphatidic acid (cPA; 1‐acyl‐sn‐glycerol‐2,3‐cyclic phosphate) is an analog of the growth factor‐like phospholipid mediator lysophosphatidic acid (LPA). As brain tissue is the richest source of cPA we tested its effects on hippocampal neurons from day 16/17 embryonic rat cultured in a serum‐free medium. Nanomolar concentrations of cPA elicited a neurotrophic effect and promoted neurite outgrowth that exceeded that of 50 ng/mL nerve growth factor (NGF). Pertussis toxin, the LPA1/LPA3 receptor‐selective antagonist dioctylglycerol pyrophosphate, the myristoylated inhibitory pseudosubstrate peptide of protein kinase A (PKI), Wortmannin and PD98059 abolished the neurite‐promoting effect. cPA elicited a sustained activation of extracellular signal‐related kinases (ERK) 1/2 and Akt. Clostridium difficile toxin B, an inhibitor of the Rho family of GTPases, reduced cPA‐induced enhancement of neurite outgrowth. In B5P cells, a clonal cell line of PC12 cells overexpressing tyrosine kinase NGF receptor (TrkA), cPA elicited transphosphorylation of TrkA. cPA‐elicited ERK activation was blocked by K252a and PKI. These results suggest that cPA mimics the effects of, and activates signaling pathways similar to, the neurotrophin NGF in cultured embryonic hippocampal neurons and B5P cells.
Predictors of quality of life ratings from persons with dementia: the role of insight

Evidence suggests that people with dementia are able to respond accurately and consistently to questions about quality of life (QoL), although large discrepancies exist between patient and proxy ratings. This may be due, in part, to the reduced insight of the person with dementia. The aim of this study was to explore the predictors of QoL ratings in a sample of people with mild dementia, with a particular focus on the role of insight.
Influence of thyroid hormone disruption on the incidence of shingles

SUMMARY The reactivation of dormant alpha-human herpesvirus (αHHV) has been attributed to various causes often referred to as stressors. However, no clinical study investigating the relationship between stressors and reactivation exists in humans at this time. Herpes simplex virus type-1 (HSV-1), an important αHHV, was shown to have its gene expression and replication regulated by thyroid hormone (TH) using molecular biology approaches. Varicella zoster virus (VZV) is categorized in αHHV superfamily and shares similar homology with HSV-1. We hypothesize that a history of TH imbalance may be associated with the incidence of shingles (VZV reactivation). This current pilot study, based on a hospital medical claims database, was conducted as a retrospective case-controlled investigation to determine if a putative link between TH imbalance and incidence of shingles is present. An odds ratio of 2·95 with a χ 2 value of 51·74 was calculated for the total population diagnosed with TH disruption and shingles. Further analyses indicated that African American males exhibited a much higher chance of simultaneous diagnoses. These results show that a TH imbalance history may affect VZV reactivation at different incidence rates in different races and age groups.
A Review of the Current Literature

Objective /Method: ADHD is often comorbid with anxiety disorders, with rates approaching 25% in many samples. This current review’s goal is to examine the literature on ADHD with comorbid anxiety from 1998 to the present. Results: Recent studies indicate that anxiety in ADHD may a) partially inhibit the impulsivity and response inhibition deficits, b) make working memory deficits worse, and c) may be qualitatively different from more phobic types of anxiety seen in pure anxiety samples. In examining subtypes of ADHD, measures of sluggish cognitive tempo show strong correlations with anxiety measures. Insights into the nature of the comorbidity between ADHD and anxiety may be gained by examining the possible comorbidity between Obsessive Compulsive Disorder and ADHD, shared risk factors for ADHD and anxiety, and the current pathogenic models of ADHD. Conclusion: The article concludes with a synthesis of the above work, along with directions for future research. (J. of Att. Dis. 2006; 10(2) 141-149)
Routine Use of Contact Precautions for Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus: Which Way Is the Pendulum Swinging?

BACKGROUND Studies have suggested that contact precautions (CP) for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus may have risks that outweigh the benefits. These risks, coupled with more widespread use of horizontal interventions such as daily bathing with chlorhexidine gluconate, have brought into question the value of routine CP for these organisms. OBJECTIVE To assess the state of utilization of CP as well as adjunctive measures to reduce the risk of transmission in US hospitals. DESIGN Cross-sectional survey. PARTICIPANTS Total of 751 physician members of the Emerging Infections Network. METHODS An 8-question electronic survey distributed by email. RESULTS A total of 426/751 (57%) responded to the survey; 337/364 (93%) of respondents use routine CP for methicillin-resistant S. aureus and 335/364 (92%) use routine CP for vancomycin-resistant enterococcus. The most widely used trigger for initiation of CP for both pathogens was positive clinical culture. Practices for discontinuation of isolation varied widely. We found that 325/354 (92%) perform routine chlorhexidine gluconate bathing and 236/353 (67%) perform S. aureus decolonization with mupirocin for 1 or more subsets of inpatients, and 82/356 (23%) reported using either hydrogen peroxide vapor or ultraviolet-C room disinfection at discharge. Free text responses noted frustration and variation in the application, practice, and process for initiation and discontinuation of CP. CONCLUSIONS Use of CP for methicillin-resistant S. aureus and vancomycin-resistant enterococcus remains commonplace, although horizontal interventions such as chlorhexidine gluconate bathing are increasingly used. The heterogeneity of practices and policies was striking. Evidence-based guidelines regarding CP and horizontal interventions are needed. Infect. Control Hosp. Epidemiol. 2015;37(1):36–40
Long-run adjustment of size, value, momentum and growth premium in equity returns: Evidence from South Asian emerging markets

ABSTRACT This study scrutinizes the long-run adjustment of risk premiums in equity returns of the emerging stock markets of Pakistan, China and India, the three emerging South Asian economies, by keeping in view leading contributions of the Fama and French (1992) and Carhart (1997) models. Unlike the multifactor models based on macroeconomic factors, this study integrates firm-specific risk factors related to the market premium. The firm-specific growth factor, derived by Ho, Strange, and Piesse (2008), is incorporated as GML, which is based on assets to market value of the firm. The results from a sample of 1 198 companies, taken from three emerging markets for the period of 2001−2013, indicate that market risk premium is the leading factor affecting risk premium in Pakistan and India. Further results reveal that, although market momentum is high enough to overestimate betas in the short run, it congregates to stabilisation and correction in the long run. In contrast, Chinese markets appear to be predominantly reflective of risk factor explaining risk premium, and are relatively more stable and efficient, clearly representing their maturity. Smaller stocks deliver higher returns with higher volatility that is apparently consistent with the general notion of high risk associated with high returns. Growth stocks outperform value stocks in the economies of Pakistan, China and India. Moreover, these markets head towards illiquidity in pre-financial crises periods, but market recovery is observed in post-financial crises periods.
Soluble receptor for advanced glycation end products in patients with decreased renal function.

BACKGROUND Advanced glycation end products (AGEs) accumulate in patients with decreased renal function and exert various toxic effects through the receptor for AGEs (RAGE). Soluble RAGE (sRAGE) is a naturally occurring inhibitor of AGE-RAGE action. The aim of the study is to describe the relationship of sRAGE to renal function and dialysis modalities. METHODS The studied group consisted of 81 patients: 25 patients with various degrees of decreased renal function, 20 long-term hemodialysis (HD) patients, 15 peritoneal dialysis (PD) patients, and 21 healthy age-matched subjects. sRAGE was assessed immunochemically (enzyme-linked immunosorbent assay), and routine biochemical parameters were measured by means of certified methods. RESULTS sRAGE level correlates positively with serum creatinine concentration (r = 0.50; P < 0.05), and its relationship to creatinine clearance is hyperbolic. sRAGE levels are elevated significantly, mainly in patients with end-stage renal disease (3,119.0 +/- 968.4 pg/mL in HD patients and 3,652.7 +/- 1,677.7 pg/mL in PD patients versus 1,405.1 +/- 426.1 pg/mL in controls; both P < 0.001 versus controls). In PD patients, sRAGE is detectable in spent dialysate (median, 75.8 pg/mL), correlates with its serum levels (r = 0.67; P < 0.05), and is related to protein losses in dialysate. In HD patients, sRAGE levels increase by 50% (P < 0.001) from 0 to 15 minutes during both HD and hemodiafiltration, and then decrease until the end of the session. CONCLUSION Serum sRAGE levels increase in patients with decreased renal function, mainly patients with end-stage renal disease. It remains to be elucidated whether the increase is caused just by decreased renal function or whether sRAGE is upregulated to protect against toxic effects of AGEs.
Patterns of Use of Smokeless Tobacco in US Adults, 2013-2014

Objectives To examine patterns of smokeless tobacco (SLT) use, by type, in wave 1 (2013-2014) of the Population Assessment of Tobacco and Health Study in the United States. Methods We analyzed data from 32 320 adults (aged ≥ 18 years) to assess the use of pouched snus and other SLT products (loose snus, moist snuff, dip, spit, and chewing tobacco). Results Overall, SLT use was most common among men, younger adults, non-Hispanic Whites, and nonurban respondents. Pouched snus users were more likely to report nondaily and polytobacco use than users of other SLT products. Respondents who used SLT some days were more likely to be current established cigarette smokers than those who used SLT every day (57.9% vs 20.2%). Furthermore, current established smokers who used SLT some days were more likely to smoke every day and had a higher median number of cigarettes smoked per day than smokers who used SLT every day. Conclusions Polytobacco use, especially cigarette smoking, is common among SLT users. Pouched snus users are more likely to report nondaily snus use and polytobacco use than users of other SLT products.
The Predictive Value of Soluble Major Histocompatibility Complex Class I Chain-Related Molecule A (MICA) Levels on Heart Allograft Rejection

Background. Recently the presence of a soluble form of major histocompatibility complex class I chain-related molecule A (sMICA) has been detected in the sera of patients with tumors. Shedding of sMICA by tumor cells downregulates NKG2D-mediated antitumor immunity. The aim of this investigation was to study the possible involvement of sMICA in the allograft acceptance after heart transplantation (HTX). Methods. We monitored the levels of sMICA by specific enzyme-linked immunosorbent assay (ELISA) in a total of 146 serum samples obtained from 34 heart transplantation patients followed up during the first year post-HTX. Results. The persistence of sMICA expression was correlated with the clinical evolution of these patients. sMICA was detected in the serum of 21 of 34 patients (61.70%) between 15 and 20 days after implantation and was practically absent in pretransplant serum samples. Twenty of these 21 patients (95.24%) with sMICA did not experience episodes of severe rejection during this period (P=0.0001), whereas sMICA was practically absent in patients with manifestations of severe acute rejection. The longitudinal study of these patients revealed that the presence of sMICA was consistently maintained in 75% of the patients with good graft status during the period of observation. Conclusion. This has led us to believe that the presence of levels of sMICA during the first year post-HTX may contribute to allograft acceptance. Additionally, functional studies indicate that sMICA downregulates NKG2D surface expression, which may lead to a functional impairment of cell-mediated cytolysis. These data suggest a significant correlation between the presence of sMICA and a lower incidence of rejection.
Variation in Individuals' Semantic Networks for Common Knowledge is Associated with False Memory

Three experiments assessed the relationships between false memories of words and their degree of connectedness within individual semantic networks. In the first two experiments, participants studied associated word lists (e.g., hot, winter, ice), completed a recognition test that included related nonstudied words (e.g., cold, snow), and then rated the semantic relatedness of all word pairs including studied and nonstudied words. In the third experiment, the task order was reversed; participants completed pairwise ratings and then, two weeks later, completed the false memory task. The relatedness ratings were analysed using the Pathfinder scaling algorithm. In all experiments, items that an individual falsely recognized had higher semantic Pathfinder node densities than those items correctly rejected.
The Information Value of Stock Lending Fees: Are Lenders Price Takers?

We find that higher stock lending fees predict significantly lower future returns after controlling for shorting demand for U.S. stocks during the period 2007–2010. These results suggest that active institutional investors on the supply side play an important role in the return predictability of fees and they not only respond to demand but also price in additional information around earnings news announcements. Overall, we find evidence that stock lenders are informed and, together with short sellers, contribute to the price discovery process.