Miracle-dz/UniFAR-FTUs huggingface dataset:
Hepatitis Virus Infections in Poultry

SUMMARY Viral hepatitis in poultry is a complex disease syndrome caused by several viruses belonging to different families including avian hepatitis E virus (HEV), duck hepatitis B virus (DHBV), duck hepatitis A virus (DHAV-1, -2, -3), duck hepatitis virus Types 2 and 3, fowl adenoviruses (FAdV), and turkey hepatitis virus (THV). While these hepatitis viruses share the same target organ, the liver, they each possess unique clinical and biological features. In this article, we aim to review the common and unique features of major poultry hepatitis viruses in an effort to identify the knowledge gaps and aid the prevention and control of poultry viral hepatitis. Avian HEV is an Orthohepevirus B in the family Hepeviridae that naturally infects chickens and consists of three distinct genotypes worldwide. Avian HEV is associated with hepatitis-splenomegaly syndrome or big liver and spleen disease in chickens, although the majority of the infected birds are subclinical. Avihepadnaviruses in the family of Hepadnaviridae have been isolated from ducks, snow geese, white storks, grey herons, cranes, and parrots. DHBV evolved with the host as a noncytopathic form without clinical signs and rarely progressed to chronicity. The outcome for DHBV infection varies by the host's ability to elicit an immune response and is dose and age dependent in ducks, thus mimicking the pathogenesis of human hepatitis B virus (HBV) infections and providing an excellent animal model for human HBV. DHAV is a picornavirus that causes a highly contagious virus infection in ducks with up to 100% flock mortality in ducklings under 6 wk of age, while older birds remain unaffected. The high morbidity and mortality has an economic impact on intensive duck production farming. Duck hepatitis virus Types 2 and 3 are astroviruses in the family of Astroviridae with similarity phylogenetically to turkey astroviruses, implicating the potential for cross-species infections between strains. Duck astrovirus (DAstV) causes acute, fatal infections in ducklings with a rapid decline within 1–2 hr and clinical and pathologic signs virtually indistinguishable from DHAV. DAstV-1 has only been recognized in the United Kingdom and recently in China, while DAstV-2 has been reported in ducks in the United States. FAdV, the causative agent of inclusion body hepatitis, is a Group I avian adenovirus in the genus Aviadenovirus. The affected birds have a swollen, friable, and discolored liver, sometimes with necrotic or hemorrhagic foci. Histologic lesions include multifocal necrosis of hepatocytes and acute hepatitis with intranuclear inclusion bodies in the nuclei of the hepatocytes. THV is a picornavirus that is likely the causative agent of turkey viral hepatitis. Currently there are more questions than answers about THV, and the pathogenesis and clinical impacts remain largely unknown. Future research in viral hepatic diseases of poultry is warranted to develop specific diagnostic assays, identify suitable cell culture systems for virus propagation, and develop effective vaccines.
Task effects on BOLD signal correlates of implicit syntactic processing

BOLD signal was measured in 16 participants who made timed font change detection judgments in visually presented sentences that varied in syntactic structure and the order of animate and inanimate nouns. Behavioural data indicated that sentences were processed to the level of syntactic structure. BOLD signal increased in visual association areas bilaterally and left supramarginal gyrus in the contrast of sentences with object- and subject-extracted relative clauses without font changes in which the animacy order of the nouns biased against the syntactically determined meaning of the sentence. This result differs from the findings in a nonword detection task (Caplan, Chen, & Waters, 2008a), in which the same contrast led to increased BOLD signal in the left inferior frontal gyrus. The difference in areas of activation indicates that the sentences were processed differently in the two tasks. These differences were further explored in an eye tracking study using the materials in the two tasks. Issues pertaining to how parsing and interpretive operations are affected by a task that is being performed, and how this might affect BOLD signal correlates of syntactic contrasts, are discussed.
Auditory pathway and auditory activation of primary visual targets in the blind mole rat (Spalax ehrenbergi): I. 2‐deoxyglucose study of subcortical centers

The blind mole rat Spalax ehrenbergi is a subterranean rodent that shows striking behavioral, structural, and physiological adaptations to fossorial life including highly degenerated eyes and optic nerves and a behavioral audiogram that indicates high specialization for low‐frequency hearing. A 2‐deoxyglucose functional mapping of acoustically activated structures, in conjunction with Nissl/Klüver‐Barrera‐stained material, revealed a typical mammalian auditory pathway with some indications for specialized low‐frequency hearing such as a poorly differentiated lateral nucleus and a well‐developed medial nucleus in the superior olive complex. The most striking finding was a marked 2‐deoxyglucose labeling of the dorsal lateral geniculate body and of cortical regions that correspond to visual areas in sighted rodents. The results render the blind mole rat a good model system for studying natural neural plasticity and intermodal compensation. In this report, we confine ourselves to the subcortical levels. The cortical level will be dealt comprehensively in a following paper.
Schema-Dependent Gene Activation and Memory Encoding in Neocortex

New hippocampal-dependent learning is in parallel consolidated with existing memories in the neocortex. When new learning occurs against the background of established prior knowledge, relevant new information can be assimilated into a schema and thereby expand the knowledge base. An animal model of this important component of memory consolidation reveals that systems memory consolidation can be very fast. In experiments with rats, we found that the hippocampal-dependent learning of new paired associates is associated with a striking up-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and that pharmacological interventions targeted at that area can prevent both new learning and the recall of remotely and even recently consolidated information. These findings challenge the concept of distinct fast (hippocampal) and slow (cortical) learning systems, and shed new light on the neural mechanisms of memory assimilation into schemas.
The Evaluation of Cord Blood Magnesium Level in Neonates of Magnesium Sulphate Treated Pre-eclamptic / eclamptic Mothers and its Clinical Correlation

This case control study was carried out on 35 neonates born to pre-eclamptic/eclamptic mothers treated with magnesium sulphate and 35 neonates born to normal healthy mothers. Cases and controls were selected by inclusionexclusion criteria irrespective of body weight and maturity of the babies. Magnesium sulphate administered to mother in study group was according to Pritchard’s intramuscular regime (1984). The cord blood samples were collected just after birth in both study and control group and magnesium level was estimated by calorimetric method. Magnesium level was found to be significantly higher in study group (6.0305±0.08047) than controls (1.916± 0.300; p = 0.0001). There was a significant difference in Apgar scores of study and control group. A negative weak linear correlation was found between cord blood magnesium level and different neonatal parameter like apgar score, birth weight and gestestional age. A weak positive linear correlation was found between magnesium level and neonatal mortality which was also not significant.
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

The expression patterns of 13 GABAA receptor subunit encoding genes (alpha 1-alpha 6, beta 1-beta 3, gamma 1-gamma 3, delta) were determined in adult rat brain by in situ hybridization. Each mRNA displayed a unique distribution, ranging from ubiquitous (alpha 1 mRNA) to narrowly confined (alpha 6 mRNA was present only in cerebellar granule cells). Some neuronal populations coexpressed large numbers of subunit mRNAs, whereas in others only a few GABAA receptor-specific mRNAs were found. Neocortex, hippocampus, and caudate-putamen displayed complex expression patterns, and these areas probably contain a large diversity of GABAA receptors. In many areas, a consistent coexpression was observed for alpha 1 and beta 2 mRNAs, which often colocalized with gamma 2 mRNA. The alpha 1 beta 2 combination was abundant in olfactory bulb, globus pallidus, inferior colliculus, substantia nigra pars reticulata, globus pallidus, zona incerta, subthalamic nucleus, medial septum, and cerebellum. Colocalization was also apparent for the alpha 2 and beta 3 mRNAs, and these predominated in areas such as amygdala and hypothalamus. The alpha 3 mRNA occurred in layers V and VI of neocortex and in the reticular thalamic nucleus. In much of the forebrain, with the exception of hippocampal pyramidal cells, the alpha 4 and delta transcripts appeared to codistribute. In thalamic nuclei, the only abundant GABAA receptor mRNAs were those of alpha 1, alpha 4, beta 2, and delta. In the medial geniculate thalamic nucleus, alpha 1, alpha 4, beta 2, delta, and gamma 3 mRNAs were the principal GABAA receptor transcripts. The alpha 5 and beta 1 mRNAs generally colocalized and may encode predominantly hippocampal forms of the GABAA receptor. These anatomical observations support the hypothesis that alpha 1 beta 2 gamma 2 receptors are responsible for benzodiazepine I (BZ I) binding, whereas receptors containing alpha 2, alpha 3, and alpha 5 contribute to subtypes of the BZ II site. Based on significant mismatches between alpha 4/delta and gamma mRNAs, we suggest that in vivo, the alpha 4 subunit contributes to GABAA receptors that lack BZ modulation.
A Prospective, Randomized, Double-Blind, Controlled Clinical Trial Comparing Laser-Assisted Lipoplasty with Suction-Assisted Lipoplasty

Background: The authors randomized and prospectively analyzed their clinical experience with the use of internal neodymium:yttrium-aluminum-garnet low-level laser-assisted lipoplasty compared with suction-assisted lipoplasty. Methods: Suction-assisted lipoplasty was generated through a SmartLipo machine and delivered into the subcutaneous tissues through 2-mm solid optical probes. Ipsilateral suction-assisted lipoplasty and contralateral laser-assisted lipoplasty were performed on one or more comparable topographic areas of the body in the same patient. Laser-assisted lipoplasty and suction-assisted lipoplasty sides of 25 patients were compared with preoperative and postoperative photographs at 3 to 5 days, 12 to 15 days, and 6 to 11 months. Statistical analysis considered surgeon and patient satisfaction, time used in the procedures, learning curves, lipocrits, operative technique, postoperative pain, edema, ecchymosis, time of recovery, body mass index, DNA proteins, free fatty acids, and cytologic patterns of post–laser-assisted lipoplasty and suction-assisted lipoplasty adipocyte architecture. Photographs were sent to the patients (blinded to the operated sides) and two plastic surgeons unfamiliar with the cases for evaluation of results. Results: All patients completed the preestablished follow-ups. No complications were observed. Less pain, lower lipocrits, higher triglycerides, and DNA cellular membrane traces were detected in the laser-assisted lipoplasty sides. All other considerations studied showed no differences with either technique in the three periods of the follow-up controls. Cytologic studies showed more damage of the adipocytes in the laser-assisted lipoplasty sides. Conclusions: No major clinical differences for suction-assisted lipoplasty versus laser-assisted lipoplasty were found. Higher concentrations of free-fatty acids after laser-assisted lipoplasty must alert us to possible hepatic and renal toxicity.
Domain Organization of the Polymerizing Mannosyltransferases Involved in Synthesis of the Escherichia coli O8 and O9a Lipopolysaccharide O-antigens*

Background: Escherichia coli O8 and O9a polysaccharide repeat units are synthesized by serotype-specific multidomain (WbdA) mannosyltransferases. Results: The various WbdA domains are functional when expressed individually. Conclusion: The number of domains identified in each WbdA protein correlates with the different linkage types formed by the enzyme. Significance: Modular glycosyltransferases could be exploited for synthesis of precise glycoconjugates with medical and industrial applications. The Escherichia coli O9a and O8 polymannose O-polysaccharides (O-PSs) serve as model systems for the biosynthesis of bacterial polysaccharides by ATP-binding cassette transporter-dependent pathways. Both O-PSs contain a conserved primer-adaptor domain at the reducing terminus and a serotype-specific repeat unit domain. The repeat unit domain is polymerized by the serotype-specific WbdA mannosyltransferase. In serotype O9a, WbdA is a bifunctional α-(1→2)-, α-(1→3)-mannosyltransferase, and its counterpart in serotype O8 is trifunctional (α-(1→2), α-(1→3), and β-(1→2)). Little is known about the detailed structures or mechanisms of action of the WbdA polymerases, and here we establish that they are multidomain enzymes. WbdAO9a contains two separable and functionally active domains, whereas WbdAO8 possesses three. In WbdCO9a and WbdBO9a, substitution of the first Glu of the EX7E motif had detrimental effects on the enzyme activity, whereas substitution of the second had no significant effect on activity in vivo. Mutation of the Glu residues in the EX7E motif of the N-terminal WbdAO9a domain resulted in WbdA variants unable to synthesize O-PS. In contrast, mutation of the Glu residues in the motif of the C-terminal WbdAO9a domain generated an enzyme capable of synthesizing an altered O-PS repeat unit consisting of only α-(1→2) linkages. In vitro assays with synthetic acceptors unequivocally confirmed that the N-terminal domain of WbdAO9a possesses α-(1→2)-mannosyltransferase activity. Together, these studies form a framework for detailed structure-function studies on individual domains and a strategy applicable for dissection and analysis of other multidomain glycosyltransferases.
Update of the drug resistance mutations in HIV-1: December 2009.

This December 2009 version of the International AIDS Society–USA (IAS–USA) drug resistance mutations list updates the figures last published in December 2008 (Johnson VA et al, Top HIV Med, 2008;16:138-145). This update includes 3 new mutations—K65R for stavudine (Hawkins CA et al, JAIDS, 2009;52:228234 and Wallis C et al, JAIDS, October 2009; Epub ahead of print) and K101P for efavirenz and nevirapine (Parkin NT et al, Antimicrob Agents Chemother, 2006;50:351-354; Rhee SY et al, Antimicrob Agents Chemother, 2004:48:31223126; and Rhee SY et al, Proc Natl Acad Sci USA, 2006;46:17355-17360). In addition, the darunavir I47V mutation and the lopinavir/ritonavir L76V mutation designations were changed to boldface to indicate their recognition as major rather than minor mutations. One mutation, L33F for tipranavir/ritonavir, was changed from a major mutation to that of a minor to reflect recent information. Also, many of the user notes were substantially revised.
Contributions à l'inférence statistique dans les modèles de régression partiellement linéaires additifs

Les modeles de regression parametrique fournissent de puissants outils pour la modelisation des donnees lorsque celles-ci s’y pretent bien. Cependant, ces modeles peuvent etre la source d’importants biais lorsqu’ils ne sont pas adequats. Pour eliminer ces biais de modelisation, des methodes non parametriques ont ete introduites permettant aux donnees elles memes de construire le modele. Ces methodes presentent, dans le cas multivarie, un handicap connu sous l’appellation de fleau de la dimension ou la vitesse de convergence des estimateurs est une fonction decroissante de la dimension des covariables. L’idee est alors de combiner une partie lineaire avec une partie non-lineaire, ce qui aurait comme effet de reduire l’impact du fleau de la dimension. Neanmoins l’estimation non-parametrique de la partie non-lineaire, lorsque celle-ci est multivariee, est soumise a la meme contrainte de deterioration de sa vitesse de convergence. Pour pallier ce probleme, la reponse adequate est l’introduction d’une structure additive de la partie non-lineaire de son estimation par des methodes appropriees. Cela permet alors de definir des modeles de regression partiellement lineaires et additifs. L’objet de la these est d’etablir des resultats asymptotiques relatifs aux divers parametres de ce modele (consistance, vitesses de convergence, normalite asymptotique et loi du logarithme itere) et de construire aussi des tests d’hypotheses relatives a la structure du modele, comme l’additivite de la partie non-lineaire, et a ses parametres.
Talking about tags: An exploratory study of librarians' perception and use of social tagging in a public library

Purpose – While examining subject headings and tags is a popular research topic, most studies focus on comparing user-assigned tags and professional subject heading. Studies that compare Library of Congress Subject Headings to user-assigned tags, for instance, dominate the literature. However, little research has involved an examination on how and to what extent these features are actually used by library staff. This study adds to the body of knowledge. This study aims to focus on how librarians perceive and use tags. By focusing on people’s perceptions rather than simply comparing social tags and formal subject headings, new insights can be collected. Design/methodology/approach – This research collects data through semi-structured interviews conducted with 12 library staff from various roles and locations throughout Auckland Libraries. Findings – The research findings show that while social tags have been adopted and used in their work by the majority of library staff interviewed, there remains resistan.
Bismuth subsalicylate: history, chemistry, and safety.

Pepto-Bismol, which contains bismuth subsalicylate (BSS) as the active ingredient, has been marketed in the United States for more than 80 years. In the gastrointestinal tract, BSS is converted to salicylic acid and insoluble bismuth salts. The salicylate portion of BSS is extensively absorbed (greater than 90%) and excreted in urine. The maximal daily dose of Pepto-Bismol (4.2 g of BSS) results in peak concentrations of salicylate in plasma considerably below the level of salicylate toxicity. In contrast, little bismuth from BSS is absorbed from the gastrointestinal tract (less than .005%). Extended dosing of Pepto-Bismol (3.14 g of BSS/d) for up to 6 weeks produced a mean concentration of bismuth in blood of 16.1 +/- 7.9 ng/g, considerably below concentrations in blood that have been reported to cause neurotoxicity. Neurotoxicity studies in animals and human safety data indicate that Pepto-Bismol can be used safely for its acute indications and for up to 3-4 weeks of extended dosing.
Folic Acid Deficiency and the Megaloblastic Anæmias

MEGALOBLASTIC antemia is the consequence of deficiency or interference with utilization of vitamin B12 or folic acid. The etiology of those megaloblastic anaemias which respond completely to treatment with vitamin B12 is fairly simple: it is due to deficiency of vitamin B12 and this is almost invariably due to a failure of its absorption; rarely to an inadequate dietary intake. The megaloblastic anemias which we shall discuss do not respond adequately to vitamin B 12, and folic acid is required in their treatment. The conditions with which these megaloblastic antmias have been associated are shown in Table I. Of these, only two occur with any degree of frequency in temperate climates,
Characterizing the scalability of a Web application on a multi‒core server

The advent of multi‒core technology motivates new studies to understand how efficiently Web servers utilize such hardware. This paper presents a detailed performance study of a Web server application deployed on a modern eight‒core server. Our study shows that default Web server configurations result in poor scalability with increasing core counts. We study two different types of workloads, namely, a workload with intense TCP/IP related OS activity and the SPECweb2009 Support workload with more application‒level processing. We observe that the scaling behaviour is markedly different for these workloads, mainly because of the difference in the performance of static and dynamic requests. While static requests perform poorly when moving from using one socket to both sockets in the system, the converse is true for dynamic requests. We show that, contrary to what was suggested by previous work, Web server scalability improvement policies need to be adapted based on the type of workload experienced by the server. The results of our experiments reveal that with workload‒specific Web server configuration strategies, a multi‒core server can be utilized up to 80% while still serving requests without significant queuing delays; utilizations beyond 90% are also possible, while still serving requests with ‘acceptable’ response times. Copyright © 2014 John Wiley & Sons, Ltd.
Violence in G-rated animated films.

CONTEXT Children's exposure to violence in the media is a possible source of public health concern; however, violence in children's animated films has not been quantified. OBJECTIVE To quantify and characterize violence in G-rated animated feature films. DESIGN Violence content was reviewed for all 74 G-rated animated feature films released in theaters between 1937 and 1999, recorded in English, and available for review on videocassette in the United States before September 1999. MAIN OUTCOME MEASURES Duration of violent scenes, type of characters participating in violent acts (good, neutral, or bad), number of injuries/fatalities, and types of weapons used for each film. RESULTS All 74 films reviewed contained at least 1 act of violence (mean duration, 9.5 minutes per film; range, 6 seconds-24 minutes). Analysis of time trends showed a statistically significant increase in the duration of violence in the films with time (P=.001). The study found a total of 125 injuries (including 62 fatal injuries) in 46 (62%) of the films. Characters portrayed as "bad" were much more likely to die of an injury than other characters (odds ratio, 23.2; 95% confidence interval, 8.5-63.4). A majority of the violence (55%) was associated with good or neutral characters dueling with bad characters (ie, using violence as a means of reaching resolution of conflict), and characters used a wide range of weapons in violent acts. CONCLUSIONS Our content analysis suggests that a significant amount of violence exists in animated G-rated feature films. Physicians and parents should not overlook videocassettes as a source of exposure to violence for children. JAMA. 2000;283:2716-2720.
Dynamic Word Embeddings for Evolving Semantic Discovery

Word evolution refers to the changing meanings and associations of words throughout time, as a byproduct of human language evolution. By studying word evolution, we can infer social trends and language constructs over different periods of human history. However, traditional techniques such as word representation learning do not adequately capture the evolving language structure and vocabulary. In this paper, we develop a dynamic statistical model to learn time-aware word vector representation. We propose a model that simultaneously learns time-aware embeddings and solves the resulting alignment problem. This model is trained on a crawled NYTimes dataset. Additionally, we develop multiple intuitive evaluation strategies of temporal word embeddings. Our qualitative and quantitative tests indicate that our method not only reliably captures this evolution over time, but also consistently outperforms state-of-the-art temporal embedding approaches on both semantic accuracy and alignment quality.