Miracle-dz/UniFAR-FTUs huggingface dataset:
Tumor subtype and other prognostic factors in breast cancer patients with brain metastases: The updated graded prognostic assessment (Breast-GPA).

1079 Background: Brain metastases (BM) are a common and fatal complication of breast cancer but survival varies widely based on various prognostic factors (PF). Hence, patient counseling and therapeutic decisions should be individualized. We previously published a prognostic index (Breast GPA) based on cohort A (1985-2007, n = 642), updated it with tumor subtype in cohort B (1993-2010, n = 400) and are now updating it with a larger contemporary cohort (C). Methods: A multi-institutional (19) multi-national (3) retrospective database of 2473 breast cancer patients with BM diagnosed from 1/1/2006-12/31/2017 was created and compared to our prior cohorts. Demographic, clinical, molecular factors, tumor subtype and treatment were correlated with survival. Kaplan-Meier survival estimates were calculated and compared with log-rank tests. Results: The median survival (MS) for cohorts A, B and C improved over time [12, 14 and 16 mo, respectively ( < 0.01)] despite the subtype distribution becoming less favorable: Luminal B (ER/PR/HER2+) decreased from 26% to 21%; HER2 (HER2+/ER/PR-) decreased from 31% to 17%, Luminal A (ER/PR+/HER2-) increased from 20% to 31%; Basal (ER/PR/HER2-) was unchanged at 24%. MS by subtype improved from 21 to 27 mo in Luminal B, 18 to 25 mo in HER2, 10 to 14 mo in Luminal A and 6 to 9 mo in Basal tumors. The number of BM was 1 in 35%, ≤4 in 67% and > 10 in 18%. PF significant for survival were tumor subtype, age, KPS, number of BM and extracranial metastases (ECM) (all < 0.01). Surprisingly, Hispanic women (7%) showed improved survival (p < 0.01). BRCA1 was mutated in 57/533 (11%) and those patients showed a trend (0.16) toward improved survival. Treatment patterns have changed: the use of whole brain radiation therapy decreased from 71% to 67% to 47% in cohorts A, B and C, respectively. Conclusions: Despite the shift to less favorable tumor subtypes, MS has improvedbut varies widely by diagnosis-specific PF. Compared to prior cohorts, number of BM and ECM were identified as new PF. Ethnic, genetic and treatment differences between the eras are apparent. The updated Breast GPA, based on these data, and the correlation between BRCA1 and tumor subtype will be presented.
Influencing Social Workers to Use Research Evidence in Practice: Lessons from Medicine and the Allied Health Professions

This study sought to identify lessons for social workers from the health care research on influencing practitioners to use evidence-based practices (EBP). Research reviews of strategies to influence providers to use EBP arere summarized. Among the findings are that printed educational materials, the use of local opinion leaders, and continuous quality improvement are weak interventions. Educational outreach visits and audit and feedback showed weak to moderate effects, whereas certain types of continuing education and use of computers showed moderate effects. Although much needs to be learned about providing social workers with the latest research knowledge, a combination of strategies is more likely to be effective.
Investigating Delay in Social Service Referral as a Predictor of Unattained Social Service Goals in Home Health Care

The present study sought primarily to determine whether attainment of social service goals was affected by the number of days between admission to home care and referral to medical social services. We also sought to determine if patient residence in a rural or urban area, annual income, and the total number of social service goals affected attainment of social service goals. Using a random sample of 306 home care patients throughout Texas, we found that the length of time between admission to home care and social service referral and annual income did not have a significant effect on social service goal attainment. However, elders living in rural areas and those having a moderate number of social service goals had significantly more unattained social service goals. Social service implications are discussed.
Frequency of orthopedic problems among patients attending an orthopedic outpatient department: a retrospective analysis of 23 495 cases

ABSTRACT BACKGROUND: Baseline statistical data on the current orthopedic outpatient load was needed to highlight the more frequent orthopedic problems. OBJECTIVE: Describe the frequency of orthopedic problems among patients attending the orthopedic outpatient department (OPD). DESIGN: Descriptive, retrospective medical record review. SETTINGS: Four-year data (2013-2017) was extracted from the computer records of patients attending the orthopedics OPD. PATIENTS AND METHODS: Computer entries of OPD visits were found, and after excluding incomplete and follow up data, age, gender, and diagnoses were described. MAIN OUTCOME MEASURES: Frequency of orthopedic diagnoses. SAMPLE SIZE AND CHARACTERISTICS: 23 495 patients, 19 377 (82.5%) males and 4118 (17.5%) females, majority (18 155, 77.3%) 19–50 years of age. RESULTS: Lower back pain (26%), tendinopathies and enthesopathies (18.3%), and bone fractures (11%) were the three common problems followed by arthritis (10.6%), nonspecific body ache (7.4%), and soft tissue injuries (9.9%). Others prominent diagnoses were ligamentous sprains (6.4%), neck-related problems (4.8%), joint stiffness (1.8%) and sports injuries (1%). CONCLUSION: This overview of the orthopedic problems in a secondary care hospital may aid in the formulation of better protocols and strategies to manage orthopedic disorders in a healthcare setting. LIMITATIONS: Retrospective and only included the primary diagnosis. CONFLICT OF INTEREST: None.
Knowledge, attitude, and practice of basic hospital management principles among medical doctors in Lokoja, Nigeria

Background: Good management skills are required by medical doctors to offer optimal service to clients (patients). Though doctors are often managers, basic hospital management principles are lacking in the training curriculum, and may affect how they organize multi-disciplinary teams or units in synergizing healthcare delivery. Aims: This study sought to determine the level of knowledge, attitude, and practice of management principles among private and public medical doctors in Lokoja. Materials and Methods: A cross-sectional study of 160 medical doctors using a pretested 23-item closed-ended questionnaire. Descriptive and bivariate analyses (using the Chi-squared, Pearson′s correlations and Students′ t-tests) were performed to compare categorical and continuous outcomes respectively. Results: A total of 70.9% of respondents were found to have a high knowledge of basic management principles, 80.6% had a positive attitude toward management principles while only 35.6% of respondents actually used formal management principles in their administrative work. Public sector doctors had significantly better knowledge (P < 0.001), positive attitudes (P < 0.003), and higher level of practice (P < 0.004) compared to private sector doctors. There was a positive linear relationship among knowledge and attitude (R = 0.47), knowledge and practice (R = 0.33), and attitude and practice (R = 0.38). Conclusion: Public sector doctors had higher knowledge and better attitudes toward management principles compared to private sector colleagues. Low levels of practice of basic management principles were seen in both groups. This study sets the groundwork for future research.
OuterSpeares: Shakespeare, Intermedia, and the Limits of Adaptation

Introduction: OuterSpeares: Shakespeare, Intermedia, and the Limits of Adaptation (Daniel Fischlin) Section 1: "Strange Invention": Shakespeare in the New Media YouTube Shakespeare and the Rhetorics of Invention (Christy Desmet) "Is there an app for that? ": Mobile Shakespeare on the Phone and in the Cloud (Jennifer Ailles) Section 2: "These violent delights have violent ends": Shakespearean Adaptation and Film Intermedia Melted into Media: Understanding Julie Taymor's Film Adaptation of The Tempest in the Wake of 9/11 and the War on Terror (Don Moore) Transgression and Transformation: Mickey B and the Dramaturgy of Adaptation - An Interview with Tom Magill (Daniel Fischlin, Tom Magill, and Jessica Riley) Section 3: "All the Uses of this World": TV, Radio, Popular Music, Theatre and the Uses of Intermedia Slings & Arrows: Pedagogical Theory and Practice in an Intermediated Shakespeare (Kim Fedderson and Michael Richardson) Your Master's Voice: The Shakespearean Narrator as Intermedial Authority on 1930s American Radio (Andrew Bretz) Sounding Shakespeare: Intermedia Adaptation and Popular Music (Daniel Fischlin) "Playing the Race Bard": How Shakespeare and Harlem Duet Sold (at) the 2006 Stratford Festival (James McKinnon) Section 4: "Give No Limits to My Tongue . I am Privileged to Speak": The Limits of Adaptation? Patchwork Shakespeare: Community Events at the American Shakespeare Tercentenary (1916) (Monika Smialkowska) Upcycling Shakespeare: Crafting Cultural Capital (Sujata Iyengar) Beyond Adaptation (Mark Fortier)
An eighth-order bandpass ΔΣ modulator for A/D conversion in digital radio

This paper examines the design and implementation of an eighth-order bandpass delta-sigma modulator. The design process is investigated from the signal flow graph level, through to the details of the switched capacitor implementation and layout considerations. Simulation results, highlighting the effects of process variation, are provided and the experimental performance of the modulator described. The modulator is implemented in a 0.8-/spl mu/m BiCMOS process and occupies an active area of 1.7 mm/sup 2/. Operating from /spl plusmn/2.5-V supplies, the fabricated prototype exhibits stable behaviour and achieves a dynamic range of 67 dB over a 200-kHz bandwidth centered at the commonly used intermediate frequency of 10.7 MHz. This paper, therefore, demonstrates the viability of high-order single-bit bandpass delta-sigma modulation.
Cultural identity in the ancient Mediterranean

Ways of becoming Arcadian : Arcadian foundation myths in the Mediterranean / Tanja S. Scheer -- Pictorial foundation myths in Roman Asia Minor / Pascale Linant de Bellefonds -- Myths, images, and the typology of identities in early Greek art / Tonio Holscher -- Herodotus and Persia / Erich S. Gruen -- Embracing ambiguity in the world of Athens and Persia / Margaret Cool Root -- "Manners makyth man" : diacritical drinking in Achaemenid Anatolia / Margaret C. Miller -- Keeping up with the Persians : between cultural identity and Persianization in the Achaemenid period / Maria Brosius -- The limits of Persianization : some reflections on cultural links in the Persian empire / Christopher Tuplin -- The pity of war : representations of Gauls and Germans in Roman art / I.M. Ferris -- Borealism : Caesar, Seneca, Tacitus, and the Roman discourse about the Germanic north / Christopher B. Krebs -- Ethnicity in Roman portraiture / Elizabeth Bartman -- Saving the barbarian / Greg Woolf -- Surviving by the book : the language of the Greek Bible and Jewish identity / Tessa Rajak -- Jewish identity at the limus : the earliest reception of the dura europos synagogue paintings / Steven Fine -- Keeping the dead in their place : mortuary practices and Jewish cultural identity in Roman North Africa / Karen B. Stern.
Ölüm ve Ölüm Kaygısı

Olum ve yasam birbirinden cok farkli kavramlar olarak gorunse de kimi goruse gore yasam ve olum bir butunu olusturmakta, olum yasamin amaci olarak kabul edilmekte ve yasami tamamlamaktadir. Farkli kulturlerde, toplumlarda, disiplinlerde bireyin kisiligine, yasina, dinine, kulturel konumuna bagli olarak da farkliliklar gosteren cok farkli olum tanimlamalari yapilmistir. Olume karsi insanlarin gosterdigi tutumlarda kisiye gore birbirinden oldukca farklilik gostermektedir. Olum kaygisi ise olum karsisinda dogumdan itibaren varolan, hayat boyu devam eden, butun korkularin temelinde yatan, karakter yapisinin gelisiminde onem tasiyan, insanin artik var olmayacaginin, kendisini ve dunyayi kaybedebileceginin, bir hic olabileceginin farkindaligi sonrasi gelisen bir duygudur. Bu gozden gecirme yazisinda olum ve olum kaygisi kavramlari; olum kaygisinin bilesenleri; olum kaygisini aciklamaya yonelik yaklasimlar; olum kaygisinin degerlendirilmesinde kullanilan olcekler ve bu konuda yapilan yurtici ve yurt disi calismalarin gozden gecirilmesi amaclanmistir.
Preserved intellectual functioning in Korsakoff’s syndrome? Actual and premorbid intelligence in patients with major or mild alcohol-related cognitive disorder

ABSTRACT Objective: Although alcoholic Korsakoff patients show profound cognitive impairments (including amnesia), intellectual function has typically been assumed to be preserved. Based on more recent models on intelligence, however, it can be hypothesized that although preserved verbal or crystallized abilities may be expected in Korsakoff patients, fluid reasoning may be significantly reduced. Aim of this study was to gain insight in intelligence profiles of patients with alcohol-related cognitive disorders with and without Korsakoff’s syndrome (KS). Method: Test performance on the Wechsler Adult Intelligence Scale – Fourth Edition (WAIS-IV) and the National Adult Reading Test (NART) was assessed in 34 patients diagnosed with KS, 40 patients with chronic alcohol-related cognitive disorder without Korsakoff’s syndrome (ALC), and 47 non-alcoholic psychiatric controls (non-ALC). Results: Analysis revealed significant lower WAIS-IV Full-Scale IQ scores compared to the estimated premorbid NART-IQ in both groups with alcohol-related cognitive disorders (KS and ALC). With respect to the index scores, KS patients performed worse than non-ALC patients on the Perceptual Reasoning and Processing Speed Indices. Performance on the Verbal Comprehension and Working Memory Indices did not differ between groups. Conclusion: Not all aspects of intelligence are preserved in Korsakoff’s syndrome and implications of assessment of intellectual function in patients with alcohol-use disorder are discussed.
Risk factors of Acute Respiratory Infection (ARI) in under-fives in a rural hospital of Central India

Introduction: Acute Respiratory Infection (ARI) is a major cause of morbidity and mortality in developing countries in children especially in under-fives. Every year in the world, about 13 million under-5 children dies, 95% from developing countries; one third of total deaths are due to ARI. The aim of this study was to identify the significant risk factors for ARI in children less than five years of age living in rural areas of Central India. Methods: A hospital based case control study was undertaken to determine risk factors associated with respiratory tract infections in children. Children less than 5 years admitted in a pediatric ward with diagnosis of ARI were enrolled in the study as cases (n = 300) while the same number of controls (n = 300) were selected from neighborhood and were matched for age, sex and religion. Details of risk factors in cases and controls were recorded in pre-designed proforma. Results : A significant association was found between ARI and lack of breastfeeding, nutritional status, immunization status, delayed weaning, prelactal feeding, living in overcrowded conditions, mothers’ literacy status, low birth weight and prematurity. Among the environmental variables, inadequate ventilation, improper housing condition, exposure to indoor air pollution in form of combustion from fuel used for cooking were found as significant risk factors for ARI in under-fives. Conclusions: ARIs are affected by socio-demographic and socio-cultural risk factors, which can be modified with simple interventions. The various risk factors identified in this study were lack of breastfeeding, undernutrition, delayed weaning, overcrowding and prelactal feeding.
Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000-2016

Setting The State of Rio de Janeiro stands out as having the second highest incidence and the highest mortality rate due to TB in Brazil. This study aims at identifying the factors associated with the unfavourable treatment of MDR/XDR-TB patients in that State. Method Data on 2269 MDR-TB cases reported in 2000-2016 in Rio de Janeiro State were collected from the Tuberculosis Surveillance System. Bivariate and multivariate logistic regressions were run to estimate the factors associated with unfavourable outcomes (failure, default, and death) and, specifically, default and death. Results The proportion of unfavourable outcomes was 41.9% among MDR-TB and 81.5% among XDR-TB. Having less than 8 years of schooling, and being an Afro-Brazilian, under 40 years old and drug user were associated with unfavourable outcome and default. Bilateral disease, HIV positive, and comorbidities were associated with death. XDR-TB cases had a 4.7-fold higher odds of an unfavourable outcome, with 29.3% of such cases being in the first treatment for multidrug resistance. Conclusion About 30% of XDR-TB cases may have occurred by primary transmission. The high rates of failure and death in this category reflect the limitation of treatment options. This highlights the urgency to incorporate new drugs in the treatment.
OPEN OR TRADITIONAL EDUCATION: REQUESTING IN INTERLANGUAGE PRAGMATICS

This paper is a comparative pragmalinguistic, sociopragmatic study of L2 request performance between learners in open and classical learning settings in Palestine. With the assumption that learners in both settings are driven by their L1 speech norms (L1 interference), the researcher tried to explain learners’ English language performance both pragmalinguistically, in regards to the level of indirectness and types of modification, and sociopragmatically, in regards to the impact of social parameters (status, distance and degree of imposition) on the level of indirectness and amount of modification. Since English and Arabic are distinct linguistically and culturally, the researcher tried to explain the extent of such influence with reference to language learning in both settings. The study was carried out at Al-Quds Open University (QOU) and the Arab American University (AAUJ) in Palestine. Discourse completion task (DCT) was used to collect relevant data, which were analyzed both quantitatively and qualitatively. The findings suggested that while QOU learners approximate L1 requesting norms pragmalinguistically and socipragmaically, AAUJ learners tend to play it safe through preference for norms that are less face threatening and more conforming to the English language traditions. The differences between the request performance of both groups of L2 learners could be attributed to the different methods of instruction and language learning policies at both universities. The study recommends a greater emphasis on face-toface meetings and the application of more interactive media for teaching and learning English as a foreign language in the open education settings.
Differences in endometrial carcinoma presentations and characteristics in pre- and postmenopausal women

Introduction/Objective. As of recently, an increasing number of premenopausal women is being diagnosed with endometrial carcinomas. The objective of our study was to determine if routinely collected clinical and imaging parameters, implying on tumor characteristics, are different in pre- and postmenopausal endometrial carcinoma patients, enabling their appropriate preoperative evaluation. Methods. The study included all patients (n = 209) operated on due to endometrial carcinoma over a period of three years. The diagnosis was based on histopathological findings of exploratory curettage. Medical history was taken for all the patients and they were divided regarding menopausal status. On preoperative ultrasound scan, the endometrial echo pattern was established. The existence of myomas, adnexal masses, free fluid in the abdomen or uterine cavity was noted. Magnetic resonance imaging detected the presence of pelvic metastases and tumor spreading into the uterine cavity, myometrium, cervix, and lymph nodes. Postoperatively, histopathological findings, the tumor stage and grade were established. Results. The majority of women were postmenopausal and secundiparous. Significantly more patients were obese, especially the postmenopausal ones (p = 0.001). Most tumors were endometrioid adenocarcinomas regardless of menopausal status. Irregular/abnormal bleeding (p = 0.037), presence of ascites (p = 0.010), obesity (p = 0.046), and lower parity (p = 0.016) correlated with postmenopausal status. Large exophytic endometrial carcinomas were predominant in younger patients (p = 0.026). Endometrial carcinomas were significantly more often diagnosed in the II FIGO stage in premenopausal patients. There were no other significant differences (endometrial thickness, uterine homogeneity, echogenicity, tumor infiltration and spreading, histopathological type and grade) between pre- and postmenopausal endometrial carcinoma patients. Conclusions. Few differences between pre- and postmenopausal endometrial carcinoma patients existed and the most prominent ones were obesity, parity, irregular/abnormal bleeding, and tumor growth into the cavity.
Technical results and complication rates after skin-sparing and nipple-sparing mastectomy and immediate implant based reconstruction using a porcine tissue matrix Strattice® for implant coverage

Skin-sparing and nipple-sparing mastectomies are increasingly used for prophylactic and therapeutic purposes and replace conventional mastectomies in selected cases. We report on our first 27 cases of skinsparing or nipple-sparing mastectomy with immediate implant based reconstruction using a porcine tissue matrix Strattice® for implant coverage. Universitatsklinik fur Spezielle Gynakologie – Brustzentrum Salzburg, Paracelsus Medizinische Privatuniversitat Salzburg Technical results and complication rates after skin-sparing and nipple-sparing mastectomy and immediate implant based reconstruction using a porcine tissue matrix Strattice® for implant coverage
Probabilistic Requirements (Partial) Verification Methods Best Practices Improvement. Variables Acceptance Sampling Calculators: Derivations and Verification of Plans

The NASA Engineering and Safety Center was requested to improve on the Best Practices document produced for the NESC assessment, Verification of Probabilistic Requirements for the Constellation Program, by giving a recommended procedure for using acceptance sampling by variables techniques. This recommended procedure would be used as an alternative to the potentially resource-intensive acceptance sampling by attributes method given in the document. This document contains the outcome of the assessment.
A current testing for CMOS static RAMs to reduce testing costs

This paper presents a methodology to reduce the testing costs of a CMOS static RAMs (SRAMs), based on a current testing. In this test method, the structure of SRAMs is modified so that all the cells can be driven simultaneously. A fault in the memory cell array can be detected by only observing the abnormal current. Since the whole cell array could be treated as if it were a single cell, the length of the test sequences is not dependent on the size of the memory cell array and must be very short. <<ETX>>
Biomarkers of inflammation as predictors of treatment response in depression

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