Miracle-dz/UniFAR-FTUs huggingface dataset:
Sweetener augmentation of serum triacylglycerol during a fat challenge test in humans.

OBJECTIVE High concentrations of fructose enhance postprandial lipemia following lipid loading whereas glucose exerts a negative or minimal effect. This study evaluated the effect of lower sweetener concentrations and the contribution of their sweetness level and palatability. METHODS At each of four test sessions, twelve male and ten female healthy adults ingested one of four milkshakes containing 108 g dairy cream alone or supplemented with 30 g fructose, 17.5 g glucose or 1 g aspartame. Blood samples were collected at baseline, two, four, six and eight hours after ingestion. Sensory discrimination tests were conducted after the last two sessions. RESULTS Fructose and glucose led to 37% (p = 0.03) and 59% (p = 0.08) rises in triacylglycerol area under the curve (TG AUC) when compared to the plain milkshake, respectively. Although the sweetened shakes were equisweet and were more palatable than the plain shake, the TG rise after the aspartame milkshake did not differ from the plain milkshake. CONCLUSIONS These data indicate that low levels of glucose and fructose consumed with lipid enhance postprandial lipemia. Sweetness and palatability did not account for the effect.
National Institute of Standards and Technology detector-based photometric scale.

The Système International base unit for photometry, the candela, has been realized by using absolute detectors rather than absolute sources. This change in method permits luminous intensity calibrations of standard lamps with an expanded uncertainty of 0.46%, almost a factor-of-2 improvement. A group of eight reference photometers has been constructed with silicon photodiodes, matched with filters to mimic the Commission Internationale de l'Eclairage spectral luminous efficiency function for photopic vision.The design, characterization, calibration, evaluation, and further application of the photometers are discussed.
Essays in Development Economics

In Chapter 1, the first essay explores a school meals program in Ethiopia. In food-insecure parts of poor countries school meals can provide a strong incentive to poor households to send their children to school. School meals appear to be attractive as they may not only increase school participation but may also improve learning and cognitive development. Chapter 2 investigates the role of poor eyesight on educational outcomes in rural Ethiopia. Chapter 3 uses data on four financial literacy training programs to examine whether financial literacy training can improve microfinance clients' risk management in order to avoid over-indebtedness and reduce vulnerability. Chapter 4 investigates the role of parental migration on children's school participation using data from Moldova. While migration, through remittances, has the potential to contribute to children's education by making more resources available, parental migration may be detrimental as it implies parental absence.
Vulnerable consumers and satisfaction with public services: does country matter?

Within Public Administration, increased attention is being paid to ‘vulnerable citizens’ – groups of citizens who, for reasons beyond their control, are disadvantaged in comparison to other citizens – when consuming public services. Initial research focused on how citizens’ socio-economic background shapes their behaviour and satisfaction. Citizens, however, take decisions within a context, but we know little about how their experiences differ depending on their country of residence. We comparatively analyse the experience of vulnerable citizens in telecommunications and electricity markets in three large European Union countries, selected to represent ‘advanced’, ‘intermediate’ and ‘laggard’ stages of reform. We first establish that citizens’ socio-economic characteristics matter for patterns of expenditure and perceptions of service affordability and then show how citizen vulnerability differs depending on country context. Results are useful to practitioners seeking to target regulation to improve the experiences of vulnerable citizens. Points for practitioners Practitioners recognize that public service reform has brought with it greater market complexity and choice, and that this poses challenges to citizens, particularly vulnerable citizens. Initial empirical work demonstrated that citizens’ socio-economic background affects their satisfaction; however, we know little about how this vulnerability is shaped by country context. We analyse electricity and telecommunications markets in three large European Union countries, establishing that consumers’ socio-economic background matters for citizens’ expenditure and perceptions of service affordability, and then demonstrating that country context also influences these experiences. Less-educated, elderly and non-employed citizens experience more frequent problems with these services than other citizens, and the country context conditions these experiences significantly.
The effect of leadership on job morale for graduate students

Leadership techniques have a vast effect on job morale and intentions to remain with an organization. Studies often base their inquiries on how to apply leadership strategies in a versatile, hierarchical format to situations that require astute leadership practices (Maslow, 1954), but do not assess the opinions of graduate students with some degree of workforce experience. Given the lack of research on the graduate student population with workforce experience, the current study sought to understand which leadership techniques have positive and negative impacts on their job morale and employee satisfaction utilizing a web-based survey. The following research questions were addressed: How have positive and negative leadership techniques been defined by graduate students who have workforce experience, and what have been the effects of positive and negative leadership techniques on job morale for these graduate students? The results of this study suggest that positive leadership techniques involving high trust levels, empowerment, and learning opportunities yielded increased levels of job morale, while poor leadership methods that involved a lack of support during times of change yielded decreased morale. The implementation of incentives did not yield significant results in either direction in terms of productivity. Future studies may wish to address in greater depth the factors that affect employee satisfaction. In order to gain a clearer understanding of this relationship, how these factors contribute to graduate student turnover rates could also be explored.
Antibiotic prophylaxis in transcatheter treatment of hepatocellular carcinoma: an open randomized prospective study of oral versus intravenous administration.

BACKGROUND Transcatheter arterial chemoembolization (TACE) and transcatheter arterial infusion chemotherapy (TAI) are increasingly used to treat inoperable liver malignancies. It has not been determined whether standard oral and intravenous administration of antibiotics have different prophylactic effects against post-TACE/TAI infection. We compared the efficacy of oral levofloxacin (LVFX) and intravenous cephazolin (CEZ) in patients receiving TACE/TAI for hepatocellular carcinoma (HCC) using a prospective design. PATIENTS AND METHODS One hundred twenty-nine eligible subjects with HCC treated by TACE/TAI were analyzed in this study. Patients were randomly assigned by the envelope method to groups who received either intravenous infusion of CEZ at 2 g/day or oral administration of LVFX at 300 mg/day for 5 days. Laboratory data, changes in antibiotic administration from the standard ones, duration of hospital stay, side effects of antibiotics, and infectious complications were assessed. RESULTS There were no significant differences in the WBC counts and serum CRP levels between the groups; there were also no significant inter-group differences in the numbers of infectious and other adverse events. CONCLUSION Our study findings suggest that the results of peroral administration of LVFX for the prevention of post-procedure infectious complications in patients receiving TACE/TAI for HCC are not inferior to those of intravenous administration of CEZ.
Ortho Evra, a New Contraceptive Patch

Ortho Evra is the first transdermal patch approved for the prevention of pregnancy. Comparative trials have shown that Ortho Evra has efficacy similar to the oral contraceptives Mercilon (not available in the United States) and Triphasil for the prevention of pregnancy when used as directed. Adverse effects with Ortho Evra are similar to those reported with combined oral contraceptives, with the exceptions of mild‐to‐moderate application‐site reactions and an increased frequency of breast symptoms. The most commonly reported adverse reactions were breast symptoms, headache, application‐site reactions, nausea and vomiting, dysmenorrhea, and abdominal pain. Approximately 5% of study subjects had at least one patch that did not stay attached to their skin, and about 2% of women withdrew from clinical trials due to irritation from the patch. In clinical studies, the patch appeared to be less effective in women weighing more than 90 kg than in women with lower body weights. More research is needed on the relationship between body weight and contraceptive patch efficacy. In two clinical trials, compliance was greater with the patch than with oral contraceptives. Whether this will result in reduced pregnancy rates in general use is unknown. Additional studies are warranted to determine if the patch offers any significant efficacy or safety advantages over current methods of hormonal contraception.
Torque ripple reduction of model predictive torque control of induction motor drives

Model predictive torque control (MPTC) has been proposed as an effective alternative to conventional direct torque control (DTC) for induction motor (IM) drives. Compared to DTC, MPTC is more effective and accurate in the vector selection by incorporating the system model directly with the finite switching states. However, due to the limited switching states in two-level inverter, applying only one voltage vector during one control period fails to reduce the torque ripple to the minimum value. This paper proposes an improved MPTC for the aim of torque ripple reduction by allocating only a fraction of control period to the active vector selected from conventional MPTC, while the rest of time is allocated for a null vector. The duration of the active vector is obtained based on the principle of torque ripple minimization. Presented simulation and experimental results prove that, compared to conventional MPTC, the proposed MPTC achieves better steady state performance by reducing both torque ripples and current harmonics. Meanwhile, the quick dynamic response of conventional MPTC is reserved.
The Impact of the Euro Area Macroeconomy on Global Commodity Prices

The aim of this paper is to analyse the links between real and financial processes in the euro area and energy and non-energy commodity prices. Monthly data spanning 1997:1 to 2013:12 and the structural VAR model are used to uncover the relationship between global commodity prices and the euro area economy. The analysis is performed for three sub-periods in order to capture potential changes in this relationship over time. The main finding is that commodity prices in the euro area do not respond to impulses from production (economic activity), whereas commodity prices strongly react to impulses from financial processes, i.e. interest rates in the euro area and the exchange rate of the dollar against the euro, especially in the run-up to the global financial crisis. The study also provides evidence of a tightening relationship between energy and non-energy commodity prices.
Lung tissue mechanics predict lung hypoplasia in a rabbit model for congenital diaphragmatic hernia

Several animal models have been proposed to study the pathophysiology of congenital diaphragmatic hernia (CDH). Surgical induction of CDH in fetal rabbits during the pseudoglandular phase has been shown to induce severe pulmonary hypoplasia, but functional studies in this model are scarce. We aimed to measure neonatal pulmonary impedance and related it to the severity of lung hypoplasia. CDH was surgically created in rabbits at 23 days of gestation. Following cesarean delivery at term (31 days) pups were subjected to measurement of total lung capacity (TLC), lung to body weight ratio (LBWR) and lung impedance by forced oscillation technique (FOT). Airway resistance (Raw), tissue elastance (HL), tissue damping (GL), and hysteresivity (η) (GL/HL) were calculated from impedance data. Twelve CDH fetuses and 15 controls were available for final analysis. LBWR and TLC were significantly lower in the CDH group compared to gestational and age matched controls (P < 0.001). Raw, HL, and GL were significantly increased in CCDH fetuses. η and HL best reflected lung hypoplasia (LBWR) (r2 = 0.42 and 0.43; P = 0.001), indicating a dominant contribution of lung tissue mechanics to CDH‐induced lung hypoplasia. We successfully introduced lung impedance measurement by FOT in neonatal rabbits. Following surgical induction of CDH in the pseudoglandular phase, they have, next to morphological evidence of pulmonary hypoplasia, changes in lung mechanics. Our results for lung tissue mechanics support the concept of delayed pulmonary tissue modeling. We propose to employ functional studies in future experiments when evaluating prenatal interventions aimed at reversing pulmonary hypoplasia. Pediatr Pulmonol. 2007; 42:505–512. © 2007 Wiley‐Liss, Inc.
Oligomers of Mutant Glial Fibrillary Acidic Protein (GFAP) Inhibit the Proteasome System in Alexander Disease Astrocytes, and the Small Heat Shock Protein αB-Crystallin Reverses the Inhibition*

The accumulation of the intermediate filament protein, glial fibrillary acidic protein (GFAP), in astrocytes of Alexander disease (AxD) impairs proteasome function in astrocytes. We have explored the molecular mechanism that underlies the proteasome inhibition. We find that both assembled and unassembled wild type (wt) and R239C mutant GFAP protein interacts with the 20 S proteasome complex and that the R239C AxD mutation does not interfere with this interaction. However, the R239C GFAP accumulates to higher levels and forms more protein aggregates than wt protein. These aggregates bind components of the ubiquitin-proteasome system and, thus, may deplete the cytosolic stores of these proteins. We also find that the R239C GFAP has a greater inhibitory effect on proteasome system than wt GFAP. Using a ubiquitin-independent degradation assay in vitro, we observed that the proteasome cannot efficiently degrade unassembled R239C GFAP, and the interaction of R239C GFAP with proteasomes actually inhibits proteasomal protease activity. The small heat shock protein, αB-crystallin, which accumulates massively in AxD astrocytes, reverses the inhibitory effects of R239C GFAP on proteasome activity and promotes degradation of the mutant GFAP, apparently by shifting the size of the mutant protein from larger oligomers to smaller oligomers and monomers. These observations suggest that oligomeric forms of GFAP are particularly effective at inhibiting proteasome activity.
Evidence of increased oxidative stress in aged mesenteric lymphatic vessels.

BACKGROUND We have previously shown that aging is associated with weakened rat mesenteric lymphatic vessel (MLV) contractility. However, the specific mechanisms contributing to this aging-associated contractile degeneration remain unknown. Aging is often associated with elevations in oxidative stress, and reactive oxygen species (ROS) have been shown to reduce the contractility of MLV. Thus in the present study, we sought to assess whether aging is associated with increased levels of oxidative stress and oxidative damage in MLV. METHODS AND RESULTS MLV were isolated from 9-mo- and 24-mo-old Fischer-344 rats and subjected to the following experimental techniques: measurement of total superoxide dismutase (SOD) activity; estimation of lipid peroxidation levels via measurement of thiobarbituric acid reactive substances (TBARS); detection of superoxide and mitochondrial ROS in live MLV; Western blot analysis, and immunohistochemical labeling of the SOD isoforms and nitro-tyrosine proteins. We found that aging is associated with increased levels of cellular superoxide and mitochondrial ROS concomitant with a reduction in Cu/Zn-SOD protein expression and total SOD enzymatic activity in MLV. This increase in oxidative stress and decrease in antioxidant activity was associated with evidence of increased lipid (as indicated by TBARS) and protein (as indicated by nitro-tyrosine labeling) oxidative damage. CONCLUSIONS Thus for the first time, we demonstrate that aging-associated increases in oxidative stress and oxidative damage is indeed present in the walls of MLV and may contribute to the aging-associated lymphatic pump dysfunction we previously reported.
225Ac-PSMA-617 for PSMA-Targeted α-Radiation Therapy of Metastatic Castration-Resistant Prostate Cancer

Prostate-specific membrane antigen (PSMA) is a promising target in prostate cancer. Recently, we started the first-in-human treatment with an α-radionuclide–labeled PSMA ligand. Although the case series is still ongoing, we here report in advance about two patients in highly challenging clinical situations who showed a complete response to 225Ac-PSMA-617 therapy. Methods: 68Ga-PSMA-11 PET/CT validated the presence of the PSMA-positive tumor phenotype. A 100-kBq activity of 225Ac-PSMA-617 per kilogram of body weight was administered bimonthly. Prostate-specific antigen response and hematologic toxicity were measured at least every 4 wk. Restaging was performed with 68Ga-PSMA-11 PET/CT. Results: Both patients experienced a prostate-specific antigen decline to below the measurable level and showed a complete response on imaging. No relevant hematologic toxicity was observed. Xerostomia was the only mentionable clinical side effect. Conclusion: Targeted α-therapy with 225Ac-PSMA-617, although still experimental, obviously has strong potential to significantly benefit advanced-stage prostate cancer patients.
The human resources management contribution to social responsibility and environmental sustainability: explorations from Ibero-America

Abstract In this paper we aim to advance the discussion on HRM’s quest to create value around social responsibility and environmental sustainability. We explore the perceptions reported by Human Resource managers in three Ibero-American countries (Spain, the Dominican Republic and Costa Rica). We focus on the hospitality sector, one of particular relevancy for these countries and with significant sustainability challenges. Relying on in-depth interviews in twenty-eight organizations and a mixed-methods approach, we examine HR managers’ underlying notions around social and environmental issues, stakeholder collaboration, HRM practices, roles and internal organization. Analysis of the interviews suggests varying views on those dimensions, as well as identifies Active and Advanced firms, the latter showing more commitment to sustainability (as part of the organizational culture), usage of HRM practices and engagement with multiple stakeholders. From this empirical exploration and relying on current sustainability developments, we contribute to the literature by outlining an externally-oriented model (centred on corporate priorities, communities’ flourishing and ecosystems’ resilience) aiming to advance HRM’s engagement with sustainability-driven agendas.
Cervical spondylotic myelopathy due to chronic compression: the role of signal intensity changes in magnetic resonance images.

OBJECT Although there is agreement that low-intensity signal changes on T1-weighted magnetic resonance (MR) images are a prognostic factor for poor outcome after surgical treatment of cervical myelopathy due to chronic cord compression, the role of high-intensity signal changes on T2-weighted images is still controversial. The aim of the present study was to determine whether T2-weighted MR imaging can help assess the prognosis of the disease. METHODS A prospective case series study was conducted. The population comprised 67 patients who underwent surgery between 1994 and 2004 to treat myelopathy caused by chronic cervical cord compression. The mean follow-up period was 39 months. Preoperative and postoperative functional status was evaluated using a modified Japanese Orthopaedic Association scale, and the recovery rate was calculated using the Hirabayashi method. Magnetic resonance images were acquired 3 months or less before surgery. High-intensity signal changes were evaluated according to the extent of these changes on T2-weighted sequences; low-intensity T1-weighted signal changes were also evaluated. In patients with low-intensity changes on T1-weighted images and in those with high-intensity changes spanning multiple levels on T2-weighted images, the authors documented a poor functional recovery. CONCLUSIONS Multisegmental high-intensity change on T2-weighted MR imaging is a more sensitive indicator of outcomes than T1-weighted signal changes because of its higher frequency in patients with advanced myelopathy.
Proton and non-proton activation of ASIC channels

The Acid-Sensing Ion Channels (ASIC) exhibit a fast desensitizing current when activated by pH values below 7.0. By contrast, non-proton ligands are able to trigger sustained ASIC currents at physiological pHs. To analyze the functional basis of the ASIC desensitizing and sustained currents, we have used ASIC1a and ASIC2a mutants with a cysteine in the pore vestibule for covalent binding of different sulfhydryl reagents. We found that ASIC1a and ASIC2a exhibit two distinct currents, a proton-induced desensitizing current and a sustained current triggered by sulfhydryl reagents. These currents differ in their pH dependency, their sensitivity to the sulfhydryl reagents, their ionic selectivity and their relative magnitude. We propose a model for ASIC1 and ASIC2 activity where the channels can function in two distinct modes, a desensitizing mode and a sustained mode depending on the activating ligands. The pore vestibule of the channel represents a functional site for binding non-proton ligands to activate ASIC1 and ASIC2 at neutral pH and to prevent channel desensitization.
Expansion of CTG repeats from human disease genes is dependent upon replication mechanisms in Escherichia coli: the effect of long patch mismatch repair revisited.

Many human hereditary disease genes have been recently associated with the expansion of CTG/GAC repeats. We have used a plasmid-based assay in Escherichia coli to investigate the instability of a (CTG/GAC) insert containing 64 repeats. Using this assay, expansions were biochemically detected and subsequently quantified. We show that the occurence of expansions within these trinucleotide repeats is dependent upon replicative mechanisms. Expansions of up to 30 repeats and deletions of almost all possible sizes occured regardless of the orientation of the insert relative to the replication origin. In contradiction to a previous report, the mismatch repair pathway was found to strongly stabilize these repeat stretches.