Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of treatment failures and survival of patients with fallopian tube carcinoma: a cooperation task force (CTF) study.

OBJECTIVE The objective of this retrospective multicenter study was to assess the pattern of failures and survival of patients with primary carcinoma of the fallopian tube. METHODS The hospital records of 88 patients with primary carcinoma of the fallopian tube were reviewed. Surgery was the initial therapy for all patients. Tumor stage was I in 21 (23.9%), II in 21 (23.9%), III in 43 (48.8%), and IV in 3 (3.4%) patients. Postoperative treatment was given without well-defined protocols. The median follow-up of survivors was 55 months (range, 7-182). RESULTS Of the 21 patients with stage I disease, 10 had no postoperative treatment and 11 had platinum-based chemotherapy. Five (23.8%) patients recurred after a median of 29 months (range, 8-93) from initial surgery. Of the 21 patients with stage II disease, 2 had no postoperative treatment, 2 underwent external pelvic irradiation, 16 received platinum-based chemotherapy, and 1 patient had oral melphalan. Eight (38.1%) patients recurred after a median of 25.5 months (range, 7-57). Of the 46 patients with stage III-IV disease, 1 patient refused chemotherapy and died after 19 months and 45 patients received platinum-based chemotherapy. A clinical complete response was obtained in 29 (64.4%) patients and a partial response in 8 (17.8%). A second-look laparotomy was performed in 14 of the 29 clinically complete responders: 12 patients were found to be in pathological complete response and 2 had persistent disease. Six (50.0%) of the former recurred after a median of 22 months (range, 13-101) from initial surgery. The two patients with persistent disease developed tumor progression after 15 and 11 months, respectively. Fifteen clinically complete responders did not undergo second-look, and 7 (46.7%) of them had a recurrence after a median of 18 months (range, 9-41). For the whole series, 5-year survival was 57%. By log-rank test, survival was related to FIGO stage (III-IV vs I-II, P = 0.0001), tumor grade (G3 vs G1 + G2, P = 0.0038), and patient age (>58.5 years vs <58.5 years, P = 0.0069), but not to histological type. The Cox model showed that FIGO stage (P = 0.0018) and patient age (P = 0.0290) were independent prognostic variables for survival. Among the patients with stage III-IV disease, 5-year survival was 55% for the patients who had residual tumor <1 cm compared with 21% for those who had larger residuum (P = 0.0169). CONCLUSIONS Primary carcinoma of the fallopian tube shares several biological and clinical features with ovarian carcinoma. However, when compared with the latter, fallopian tube carcinoma more often tends to recur in retroperitoneal nodes and distant sites. Stage, patient age, and, among patients with advanced disease, residual tumor after initial surgery represent important prognostic variables for survival.
Major depression and bipolar disorders in CADASIL: a study using the DSM‐IV semi‐structured interview

Valenti R, Pescini F, Antonini S, Castellini G, Poggesi A, Bianchi S, Inzitari D, Pallanti S, Pantoni L. Major depression and bipolar disorders in CADASIL: a study using the DSM‐IV semi‐structured interview. Acta Neurol Scand: 2011: 124: 390–395. © 2011 John Wiley & Sons A/S.
DISPLAY OF PREDICTOR RELIABILITY ON A COCKPIT DISPLAY OF TRAFFIC INFORMATION

Abstract : To improve the availability of information to the pilot concerning other traffic, the concept of a Cockpit Display of Traffic Information (CDTI) has been developed through efforts by NASA. These displays make information about the pilot's own aircraft and others in the flying environment visible, enabling pilots see potential conflicts and avoid them with the most effective maneuvering. These displays support the challenge of free flight, where the pilot becomes more autonomous in deciding exact routing of his aircraft between destinations. With this autonomy from Air Traffic Control, comes an increase in requirements for the pilot to be aware of the position of both his own aircraft and other traffic that may pose a conflict. Therefore, information about ownship and othership's current and future positions must be displayed so the pilot can choose a course, speed, and altitude that will maintain safe separation from other aircraft. To increase the efficiency of maneuvers (saving costs in terms of fuel and delays) the pilot will need to make maneuvering decisions based on predicted aircraft separation well in advance of a possible conflict. The development of this CDTI system has raised several psychological issues, many of which have already been investigated.
Women with Chronic Hepatitis C Virus Infection: Recommendations for Clinical Practice

Abstract The natural history of hepatitis C virus infection differs between women and men. Women demonstrate a slow rate of disease progression until menopause. Older women are more likely to develop fibrosis and are less responsive than younger women to pegylated interferon and ribavirin. Women of childbearing age have higher rates of sustained virologic response, but current therapies are contraindicated during pregnancy. Vertical transmission of hepatitis C virus occurs, but data supporting recommendations for prevention of mother-to-infant transmission are limited.
The French addictovigilance network clinical assessment: Z-drugs, true false twins

ABSTRACT Introduction: In France, an addictovigilance network is responsible for evaluating drug dependence, by drawing on pharmacoepidemiological studies, clinical studies and by assessing healthcare professionals’ reports on problematic consumption. Methods: The aim of this study was to determine whether zolpidem and zopiclone have different dependence profiles, based on healthcare professionals’ reports, and to identify various consumer dependence profiles among zolpidem users and among zopiclone users. Dependence in reports was assessed using the EGAP scale; a scale developed using the DSM diagnostic dependence criteria. Results: The comparison of dependence profiles for zolpidem and zopiclone showed differences both in total EGAP score and EGAP item positivity. The descriptive analysis showed that EGAP scores were higher for zolpidem than for zopiclone, suggesting more severe problematic consumption with zolpidem. For zolpidem 2 subpopulations of consumers were identified, with one subpopulation’s consumption being more severe than the other, with a significantly higher total EGAP score and more harmful consequences. No subpopulation was highlighted for zopiclone. Conclusion: These results were in favour of a higher prevalence of physical and compulsive signs of dependence and of harmful consequences of dependence, with zolpidem than with zopiclone.
Antibacterial activity of pomegranate fruit peels and arils

The in vitro antibacterial activities of different extracts of pomegranate fruit peels and arils (with seeds) were investigated by agar-well diffusion and broth dilution methods against four food-related bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Salmonella typhimurium). The solvents used as extractants in this study were hot water, 95% ethanol, and acetone. Their total phenolic contents were also evaluated. All pomegranate extracts contained high levels of phenolics and exhibited antibacterial activity against all bacteria tested. The hot-water extract of the peels was the most potent with the minimal inhibitory concentration of 207 mg/ml against E. coli and less than 103.6 mg/ml against the other bacteria. Gram-positive bacteria were generally more sensitive to the extracts than Gram-negative ones.
The interaction of subsyllabic encoding and stress assignment: A new examination of an old problem in Spanish

This study employs a naming task to examine the role of the syllable in speech production, focusing on a lesser-studied aspect of syllabic processing, the interaction of subsyllabic patterns (i.e., syllable phonotactics) and higher-level prosody, in this case, stress assignment in Spanish. Specifically, we examine a controversial debate in Spanish regarding the interaction of syllable weight and stress placement, showing that traditional representations of weight fail to predict the differential modulation of stress placement by rising versus falling diphthongs in Spanish nonce forms. Our results also suggest that the internal structure of the syllable plays a larger role than is assumed in the processing literature in that it modulates higher-level processes such as stress encoding. Our results thus inform the debate regarding syllable weight in Spanish and linguistic theorising more broadly, as well as expand our understanding of the importance of the syllable, and more specifically its internal structure, in modulating word processing.
A comparison of isometric strength and dynamic lifting capability.

A laboruiory study was conducted to determine if job specific static strength can be used to predict dynamic lifting capability (maximum acceptable weight of lift) based on psychophysical methodology. Nine male college students were required to lift three different tote boxes (containers) from a 38 cm height to a 81 cm high table using a semi-squat body posture. For each tote boxsialic strength was measured in three different ways. These were (i) maximum voluntary isometric strength (MVIS) measured at the origin in a vertical direction, (ii) MVIS measured close to the body in a vertical direction, and (iii) maximum acceptable weight that a subject could hold for 3 s at the origin of the dynamic lift, MVIS al the origin of lift, MVIS close to the body and holding the tote box explained 24.32 and 62% variation, respectively, in dynamic lifting capability. On the average, MVIS al the origin of lift, MVIS close to the body and holding the tote box were 46. 120. 72%, respectively, of dynamic lifting strength.
Pronuclear formation and intracellular glutathione content of in vitro-matured porcine oocytes following in vitro fertilisation and/or electrical activation

Summary Pronuclear formation and intracellular content of glutathione, containing reduced and oxidised forms, in porcine oocytes matured in vitro were determined following insemination and/or electrical stimulation. After insemination, sperm penetration had occurred as early as 3 h and female pronuclei had formed by 6 h with complete development by 12 h. Male pronuclear formation occurred, primarily, between 9 and 12 h after insemination. Glutathione content of the oocytes decreased following sperm penetration and remained at a depressed level until 12 h. After electrical stimulation, oocyte activation had occurred and female pronuclei had formed by 3 and 6 h, respectively. Oocyte glutathione content did not change as a result of oocyte activation. When oocytes were exposed to an electrical pulse and then spermatozoa, female pronuclear formation was observed by 3 h after stimulation/insemination. Sperm penetration was observed between 3 and 9 h. However, the incidence of male pronuclear formation observed at 12 h was extremely low, although sperm decondensation had occurred in some oocytes. Oocyte glutathione content had not decreased by 6 h following electrical activation. These results demonstrate that the changes in glutathione content in porcine oocytes following fertilisation in vitro differ from those due to electrical activation. Further, the decreased intracellular glutathione content in oocytes activated by sperm penetration appears to be due to the presence of a sperm factor.
Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages

Inbred strains of mice differ considerably in their innate resistance to leishmanial infection. BALB/c mice are highly susceptible to cutaneous leishmaniasis caused by Leishmania major, whereas CBA mice are resistant. We now show that this resistance correlates with the ability of macrophages to synthesize nitric oxide (NO) following activation with interferon‐γ or tumor necrosis factor α. Furthermore, the larger amounts of NO generated by resistant macrophages are related to higher levels of NO synthase activity, a difference which is not attributable to the number or the affinity of the receptors for interferon‐γ on these cells. The level of NO synthesis by activated macrophages was also correlated to the resistance in a number of other inbred mouse strains tested; macrophages from the resistant B10.S, C57BL and C3H mice produced significantly higher levels of NO than the macrophages from the susceptible BALB.b and DBA/2 mice.
Competition between Ammonia-Oxidizing Bacteria and Benthic Microalgae

ABSTRACT The abundance, activity, and diversity of ammonia-oxidizing bacteria (AOB) were studied in prepared microcosms with and without microphytobenthic activity. In the microcosm without alga activity, both AOB abundance, estimated by real-time PCR, and potential nitrification increased during the course of the experiment. AOB present in the oxic zone of these sediments were able to fully exploit their nitrification potential because NH4+ did not limit growth. In contrast, AOB in the alga-colonized sediments reached less than 20% of their potential activity, suggesting starvation of cells. Starvation resulted in a decrease with time in the abundance of AOB as well as in nitrification potential. This decrease was correlated with an increase in alga biomass, suggesting competitive exclusion of AOB by microalgae. Induction of N limitation in the oxic zone of the alga-colonized sediments and O2 limitation of the majority of AOB in darkness were major mechanisms by which microalgae suppressed the growth and survival of AOB. The competition pressure from the algae seemed to act on the entire population of AOB, as no differences were observed by denaturing gradient gel electrophoresis of amoA fragments during the course of the experiment. Enumeration of bacteria based on 16S rRNA gene copies and d-amino acids suggested that the algae also affected other bacterial groups negatively. Our data indicate that direct competitive interaction takes place between algae and AOB and that benthic algae are superior competitors because they have higher N uptake rates and grow faster than AOB.
Emerging Therapeutic Strategies for Asthma Management

OBJECTIVE The describe the mechanisms of action of and clinical experience to date with novel asthma drug therapies. DATA SOURCES This article is based, in part, on a presentation given by Eli O. Meltzer, MD, at a symposium entitled. New Frontiers in Asthma Management: Biotechnology for Optimal Therapeutic and Economic Outcomes. at the Academy of Managed Care Pharmacy's 15th Annual Meeting and Showcase in Minneapolis, Minnesota, on April 10, 2003. CONCLUSIONS Various elements of the pathophysiologic processes involved in allergic asthma, including type 2 helper T lymphocytes, cytokines, and immunoglobulin E (IgE), have been the targets of new drug research. Clinical experience with omalizumab, a humanized anti-IgE monoclonal antibody, is promising.
Cancer and Thrombosis: from Phlegmasia Alba Dolens to Transgenic Mice

Thrombosis is the most frequent complication and the second cause of death in patients with overt malignant diseases. Increasing evidence suggests that thrombotic episodes may also precede the diagnosis of cancer by months or years thus representing a potential marker for occult malignancy. Recently, emphasis has been given to the potential risk of cancer therapy (both surgery and chemotherapy) in enhancing the risk for thromboembolic disease. Post-operative deep-vein thrombosis is indeed more frequent in patients operated for malignant diseases than for other disorders. On the other hand, both chemotherapy and hormone therapy are associated with an increased thrombotic risk, which can be prevented by low-dose oral anticoagulation. Possible contributory causes for thromboembolic disease in cancer include the capacity of tumor cells and their products to interact with platelets, clotting and fibrinolytic systems, as well as their interactions with endothelial cells and tumor-associated macrophages. In particular, procoagulant activities of tumor cells have been extensively studied; one of these, cancer procoagulant, could represent a novel marker of malignancy in both solid tumors and acute promyelocytic leukemia (APL). In solid tumors, CP, a vitamin K dependent enzyme could represent the selective target of the antimetastatic effects of warfarin treatment. In APL, CP may contribute to trigger the well known intravascular coagulation syndrome accompanying the early manifestations of the disease and is depressed by all-trans-retinoic acid, an agent capable to determine complete remission with a rapid amelioration of the bleeding syndrome. (ABSTRACT TRUNCATED AT 250 WORDS)
Intra-organisational quality measurement: the case of cellular mobile services

The objective of this research is to analyse intra-organisational quality dimensions in the context of cellular mobile services. Initially, dimensions were derived based on the combination of literature review and insights gained through exploratory interviews. This was followed by a questionnaire-based survey administered to professionals working in cellular mobile service providers in India. There were 146 respondents to this survey. The survey items were subjected to exploratory factor analysis, which was followed by confirmatory factor analysis. The instrument was tested for unidimensionality, reliability, construct and criteria related validity. The resulting validated instrument can be used by cellular mobile service providers for periodic monitoring of quality level within their organisation. Further, an internal quality index derived by aggregating the scores can also be developed, which would give an indication of the performance of an organisation and provide directions to managers where the improvement efforts need to be targeted.
Genome‐wide identification of genes required for growth of Saccharomyces cerevisiae under ethanol stress

The Saccharomyces cerevisiae deletion collection was screened for impaired growth on glucose‐based complex medium containing 6% ethanol. Forty‐six mutants were found. Genes encoding proteins involved in vacuolar function, the cell integrity pathway, mitochondrial function, subunits of the co‐chaperone complex GimC and components of the SAGA transcription factor complex were in this way found to be important for the growth of wild‐type Saccharomyces yeast in the presence of ethanol. Several mutants were also sensitive to Calcofluor white (14 mutants), sorbic acid (9), increased temperature (5) and NaCl (3). The transcription factors Msn2p and Ars1p, tagged with green fluorescent protein, were translocated to the nucleus upon ethanol stress. Only one of the genes that contain STRE elements in the promoter was important under ethanol stress; this was TPS1, encoding trehalose 6‐phosphate synthase. The map kinase of the cell integrity pathway, Slt2p, was phosphorylated when cells were treated with 6% ethanol. Two out of three mutants tested fermented 20% glucose more slowly than the wild‐type. Copyright © 2006 John Wiley & Sons, Ltd.
Fast evaluation of electromagnetic interference between antenna and PCB traces for compact mobile devices

This paper proposes a technique for the fast evaluation of antenna-induced noise at the terminations of PCB traces on compact mobile phones platforms. The main approach is based on the classical theory of transmission lines with external field excitation. We show that a single full-wave electromagnetic simulation is needed to compute the coupling coefficients for an arbitrary location of the trace on the phone PCB. Therefore, the approach is ideally suited for the automated incorporation of EMI constraints within routing and placement algorithms and for parametric and what-if analyses.
Forecasting Performance of Random Walk with Drift and Feed Forward Neural Network Models

In this study, linear and nonlinear methods were used to model forecasting performances on the daily crude oil production data of the Nigerian National Petroleum Corporation (NNPC). The linear model considered here is the random walk with drift, while the nonlinear model is the feed forward neural network model. The results indicate that nonlinear methods have better forecasting performance greater than linear methods based on the mean error square sense. The root mean square error (RMSE) and the mean absolute error (MAE) were applied to ascertain the assertion that nonlinear methods have better forecasting performance greater than linear methods. Autocorrelation functions emerging from the increment series, that is, log difference series and difference series of the daily crude oil production data of the NNPC indicates significant autocorrelations. As a result of the foregoing assertion we deduced that the daily crude oil production series of the NNPC is not firmly a random walk process. However, the original daily crude oil production series of the NNPC was considered to be a random walk with drift when we are not trying to forecast immediate values. The analysis for this study was simulated using MATLAB software, version 8.03.
Study of the log. layer structure in wall turbulence over a very large range of Reynolds number

An investigation was conducted of the logarithmic layer structure in turbulent boundary layers spanning three orders of magnitude change in Reynolds number. This was achieved by using two laboratory scale facilities and the atmospheric surface layer at the SLTEST facility in Utah. Several experimental techniques were used in order the probe the three-dimensional nature of the flow structures. Two-point correlation statistics are found to agree well over all Reynolds numbers with outer flow scaling, and large-scale coherence recently noted in the logarithmic region of laboratory-scale boundary layers are also present in the atmospheric surface layer flow.
Insights into Augmented Repairs of the Lateral Ankle Ligaments

Chronic ankle instability can be a disabling condition requiring surgical correction. The Brostrom procedure is the most common repair technique used for primary repair of the lateral ankle ligaments. Infrequently, this procedure fails and requires revisional surgery. Revisional cases necessitate augmentation to strengthen the repair. Highdemand athletes, patients with high Body Mass Indexes, and patients with conditions associated with ligamentous laxity may also require augmentation during the primary surgical procedure. Augmented repair techniques include use of xenografts, allograft repair techniques, and proprietary kits that use suture anchors, non-absorbable tape, and non-absorbable sutures to repair the ankle construct. Augmentation offers superior repair strength beyond the typical construct of a Brostrom repair and is indicated for use in revisional procedures and in patients with physically demanding lifestyles.
Adaptation to lowest density regions with application to support recovery

A scheme for locally adaptive bandwidth selection is proposed which sensitively shrinks the bandwidth of a kernel estimator at lowest density regions such as the support boundary which are unknown to the statistician. In case of a H\"{o}lder continuous density, this locally minimax-optimal bandwidth is shown to be smaller than the usual rate, even in case of homogeneous smoothness. Some new type of risk bound with respect to a density-dependent standardized loss of this estimator is established. This bound is fully nonasymptotic and allows to deduce convergence rates at lowest density regions that can be substantially faster than $n^{-1/2}$. It is complemented by a weighted minimax lower bound which splits into two regimes depending on the value of the density. The new estimator adapts into the second regime, and it is shown that simultaneous adaptation into the fastest regime is not possible in principle as long as the H\"{o}lder exponent is unknown. Consequences on plug-in rules for support recovery are worked out in detail. In contrast to those with classical density estimators, the plug-in rules based on the new construction are minimax-optimal, up to some logarithmic factor.