Miracle-dz/UniFAR-FTUs huggingface dataset:
Moving towards universal health coverage: The need for a strengthened planning process

As countries embrace the ambitious universal health coverage (UHC) agenda whose major tenents include reaching everyone with the needed good quality services, strengthening the planning process to work towards a common objective is paramount. Drawing from country experiences-Swaziland and Zanzibar, we reviewed strategic planning processes to assess the extent to which they impact on realising alignment towards a collective health sector objective. Employing qualitative approaches, we reviewed strategic plans under implementation in the health sector and using an interview guide consisting of open-ended questions, interviewed key informants at the national and district level. Results showed that strategic plans are too many with majority of program strategies not well aligned to the health sector strategic plan, are not costed, and there overlaps in objectives among the several strategies addressing the same program. Weaknesses in the development process, perceived poor quality of the strategies, limited capacity, high staff turnover, and inadequate funding were the identified challenges that abate the utility of the strategic plans. Moving towards UHC starts with a robust planning process that rallies all actors and all available resources around a common objective. The planning process should be strengthened through ensuring participatory processes, evidence informed prioritisation, MoH institutional capacity to lead the process, and consideration for implementation feasibility. Flexibility to take into consideration emerging evidence and new developments in global health needs consideration.
Drunkorexia: Disordered eating behaviors and risky alcohol consumption among adolescents

The first goal of our study was to examine the differences on disordered eating and alcohol consumption among heavy, occasional restrictors, and non-restrictors in a sample of 823 adolescents. The second goal was to analyze the relation of drunkorexia between unhealthy eating and alcohol use. Our results showed that heavy restrictors reported more eating disorder symptoms and alcohol use than occasional restrictors and non-restrictors. Similarly, occasional restrictors showed more unhealthy eating and drinking behaviors than non-restrictors. Both disordered eating and alcohol use were significant predictors of drunkorexia, supporting the argument of drunkorexia as an overlapping of dysfunctional eating and drinking patterns.
Perceived Attitudes About Substance Use in Anonymous Social Media Posts Near College Campuses: Observational Study

Background Substance use is a major issue for adolescents and young adults, particularly college students. With the importance of peer influence and the ubiquitous use of social media among these age groups, it is important to assess what is discussed on various social media sites regarding substance use. One particular mobile app (Yik Yak) allowed users to post any message anonymously to nearby persons, often in areas with close proximity to major colleges and universities. Objective This study describes the content, including attitude toward substances, of social media discussions that occurred near college campuses and involved substances. Methods A total of 493 posts about drugs and alcohol on Yik Yak were reviewed and coded for their content, as well as the poster’s attitude toward the substance(s) mentioned. Results Alcohol (226/493, 45.8%), marijuana (206/493, 41.8%), and tobacco (67/493, 13%) were the most frequently mentioned substances. Posts about use (442/493) were generally positive toward the substance mentioned (262/442, 59.3%), unless the post was about abstinence from the substance. Additionally, posts that commented on the substance use of others tended to be less positive (18/92, 19.6% positive) compared to posts about one’s own use (132/202, 65.3% positive). Conclusions This study provides a description of anonymous discussions on or near college campuses about drugs and alcohol, which serves as an example of data that can be examined from social media sites for further research and prevention campaigns.
Multiday EMG-Based Classification of Hand Motions with Deep Learning Techniques

Pattern recognition of electromyography (EMG) signals can potentially improve the performance of myoelectric control for upper limb prostheses with respect to current clinical approaches based on direct control. However, the choice of features for classification is challenging and impacts long-term performance. Here, we propose the use of EMG raw signals as direct inputs to deep networks with intrinsic feature extraction capabilities recorded over multiple days. Seven able-bodied subjects performed six active motions (plus rest), and EMG signals were recorded for 15 consecutive days with two sessions per day using the MYO armband (MYB, a wearable EMG sensor). The classification was performed by a convolutional neural network (CNN) with raw bipolar EMG samples as the inputs, and the performance was compared with linear discriminant analysis (LDA) and stacked sparse autoencoders with features (SSAE-f) and raw samples (SSAE-r) as inputs. CNN outperformed (lower classification error) both LDA and SSAE-r in the within-session, between sessions on same day, between the pair of days, and leave-out one-day evaluation (p < 0.001) analyses. However, no significant difference was found between CNN and SSAE-f. These results demonstrated that CNN significantly improved performance and increased robustness over time compared with standard LDA with associated handcrafted features. This data-driven features extraction approach may overcome the problem of the feature calibration and selection in myoelectric control.
Physical Layer Security in Buffer-State-Based Max-Ratio Relay Selection Exploiting Broadcasting With Cooperative Beamforming and Jamming

In this paper, we propose a novel secure buffer-aided decode-and-forward relay selection that amalgamates the benefits of the buffer-state-based relay selection, the max-ratio criterion, the simultaneous activation of multiple source-to-relay links, and the cooperative beamforming in dual-hop networks. More specifically, the proposed scheme is designed for selecting a single or multiple relay nodes for packet reception or transmission based on the buffer states of relay nodes, while avoiding the detrimental effects of both an empty buffer state and a buffer overflow. Analytical bounds on the secrecy outage probability and the average delay are derived for our proposed scheme, based on a Markov chain process, in order to verify the system model of our proposed scheme. Furthermore, we introduce the concept of cooperative jamming into the proposed scheme, in order to interfere with an eavesdropper’s reception, while dispensing with the full channel state information associated with an eavesdropper at a central coordinator. Our simulation results demonstrate that the proposed schemes outperform the existing buffer-based secure relay selection schemes, in terms of both the secrecy outage probability and the average delay, as the explicit benefits of our novel introduced concepts.
Trans-Ethnic Polygenic Analysis Supports Genetic Overlaps of Lumbar Disc Degeneration With Height, Body Mass Index, and Bone Mineral Density

Lumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI). Like most other complex traits, LDD is likely polygenic and influenced by both genetic and environmental factors. However, genome-wide association studies (GWASs) of LDD have uncovered few susceptibility loci due to the limited sample size. Previous epidemiology studies of LDD also reported multiple heritable risk factors, including height, body mass index (BMI), bone mineral density (BMD), lipid levels, etc. Genetics can help elucidate causality between traits and suggest loci with pleiotropic effects. One such approach is polygenic score (PGS) which summarizes the effect of multiple variants by the summation of alleles weighted by estimated effects from GWAS. To investigate genetic overlaps of LDD and related heritable risk factors, we calculated the PGS of height, BMI, BMD and lipid levels in a Chinese population-based cohort with spine MRI examination and a Japanese case-control cohort of lumbar disc herniation (LDH) requiring surgery. Because most large-scale GWASs were done in European populations, PGS of corresponding traits were created using weights from European GWASs. We calibrated their prediction performance in independent Chinese samples, then tested associations with MRI-derived LDD scores and LDH affection status. The PGS of height, BMI, BMD and lipid levels were strongly associated with respective phenotypes in Chinese, although phenotype variances explained were lower than in Europeans which would reduce the power to detect genetic overlaps. Despite of this, the PGS of BMI and lumbar spine BMD were significantly associated with LDD scores; and the PGS of height was associated with the increased the liability of LDH. Furthermore, linkage disequilibrium score regression suggested that, osteoarthritis, another degenerative disorder that shares common features with LDD, also showed genetic correlations with height, BMI and BMD. The findings suggest a common key contribution of biomechanical stress to the pathogenesis of LDD and will direct the future search for pleiotropic genes.
Circulating Angiogenic T Cells Are Increased in Lupus Nephritis Patients

Background Patients with systemic lupus erythematosus (SLE), especially with lupus nephritis (LN), undergo vascular damage and repair during the course of the disease. Since the recently identified angiogenic T cells (Tang) are involved in endothelial repair coupled with endothelial progenitor cells (EPCs), this study investigated the circulating Tang cells in LN patients and their potential correlations with disease features. Material/Methods Circulating Tang cells and EPCs were assessed by flow cytometry in peripheral blood samples from 67 SLE patients; of these, 32 had LN and 30 were matched healthy controls (HCs). The plasma levels of interleukin IL-17, IL-8, and vascular endothelial growth factor (VEGF) were quantified by immunoassays. Results The percentage of circulating Tang cells in LN patients was significantly increased as compared to the non-LN patients and HCs, and they were positively correlated with the level of EPC and VEGF. Additionally, circulating Tang cell percentages were positively correlated with the extent of proteinuria in LN patients. Conclusions The increased levels of circulating Tang cells in LN patients might play a role in the balance of endothelium dysfunction in these patients.
$PROST$ : Privacy-Preserving and Truthful Online Double Auction for Spectrum Allocation

Spectrum auction is an effective way to redistribute scarce spectrum resources. However, most spectrum auction designs only target at economic robustness, while neglecting the inherent privacy leakage problem. Existing secure spectrum auction mechanisms fail to provide adequate security, and they all neglect the online fashion of spectrum request arrival. In this paper, for the first time, we propose a Privacy-pReserving and truthful Online double auction mechanism for Spectrum allocaTion in wireless networks, PROST. Compared with the state-of-the-art solutions, PROST provides a comprehensive and strong protection for users’ sensitive information, especially for location privacy and time dynamics. PROST is constructed based on our carefully designed security building blocks, which support various arithmetics over encrypted real numbers, and they are also well applicable in other spectrum auctions. Besides, we improve on the existing online spectrum auction mechanisms by designing a novel privacy-preserving buyer grouping protocol for spectrum reuse. We not only theoretically prove that PROST can realize an all-round security against semi-honest adversaries but also extensively evaluate its performance. Experimental results validate that PROST achieves nice spectrum allocation efficiency with light computation and communication costs.
Epidemiology of Nontuberculous Mycobacteriosis

Abstract Annual prevalence estimates for pulmonary nontuberculous mycobacterial (PNTM) disease in the contiguous United States range from 1.4 to 13.9 per 100,000 persons, while one study found an annual prevalence of up to 44 per 100,000 persons in Hawaii. PNTM prevalence varies by region, sex, and race/ethnicity, with higher prevalence among women and persons of Asian ancestry, as well as in the Southern United States and Hawaii. Studies consistently indicate that PNTM prevalence is increasing, with estimates ranging from 2.5 to 8% per year. Most PNTM disease is associated with Mycobacterium avium complex (MAC), although the proportion of disease attributed to MAC varies by region. Host factors identified as influencing disease risk include structural lung disease, immunomodulatory medication, as well as variants in connective tissue, mucociliary clearance, and immune genes. Environmental variables including measures of atmospheric moisture and concentrations of certain soil factors have also been shown to correlate with higher PNTM prevalence. Prevalence of extrapulmonary NTM disease is lower, stable, and associated with different risk factors, including primary immune deficiencies or HIV infection.
Circular RNA ciRS-7 Maintains Metastatic Phenotypes as a ceRNA of miR-1299 to Target MMPs

Circular RNA ciRS-7 has been reported to act as a competing endogenous RNA (ceRNA) of the miRNA miR-7, resulting in reduced miR-7 activity and increased miR-7–targeted transcripts. However, it is unknown if ciRS-7 harbors other miRNAs with regulatory roles in triple-negative breast cancer (TNBC). The present study determined that the expression of ciRS-7 in TNBC clinical specimens and representative cells is significantly higher than other breast cancer subtypes. Functionally, downregulation of ciRS-7 inhibited cell migration and invasion of TNBC cells. Knockdown of ciRS-7 expression also inhibited the liver and lung metastasis of TNBC cells in vivo. Mechanistic studies revealed that ciRS-7 contains 20 miR-1299–binding sites and functions as a ceRNA of miR-1299 in TNBC cells. High expression of ciRS-7 maintains the high migration and invasion properties of TNBC cells by acting as a ceRNA of miR-1299 to enhance the expression of matrix metalloproteinases family members (MMP). Implications: Circular RNA ciRS-7 is highly expressed in TNBC tumor specimens and cells, and its downregulation inhibits cell migration and invasion of TNBC cells in vitro and in vivo. In addition, ciRS-7 functions as a ceRNA of miR-1299 to enhance the expression of MMPs, which maintains the high migration and invasion properties of TNBC cells. Mol Cancer Res; 16(11); 1665–75. ©2018 AACR.
Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy

There has been significant progress in utilizing our immune system against cancer, mainly by checkpoint blockade and T cell-mediated therapies. The field of cancer immunotherapy is growing rapidly but durable clinical benefits occur only in a small subset of responding patients. It is currently recognized that cancer creates a suppressive metabolic microenvironment, which contributes to ineffective immune function. Metabolism is a common cellular feature, and although there has been significant progress in understanding the detrimental role of metabolic changes of the tumor microenvironment (TEM) in immune cells, there is still much to be learned regarding unique targetable pathways. Elucidation of cancer and immune cell metabolic profiles is critical for identifying mechanisms that regulate metabolic reprogramming within the TEM. Metabolic targets that mediate immunosuppression and are fundamental in sustaining tumor growth can be exploited therapeutically for the development of approaches to increase the efficacy of immunotherapies. Here, we will highlight the importance of metabolism on the function of tumor-associated immune cells and will address the role of key metabolic determinants that might be targets of therapeutic intervention for improvement of tumor immunotherapies.
Safety and Side Effects of Rifampin versus Isoniazid in Children

BACKGROUND The treatment of latent infection with Mycobacterium tuberculosis is important in children because of their vulnerability to life‐threatening forms of tuberculosis disease. The current standard treatment — 9 months of isoniazid — has been associated with poor adherence and toxic effects, which have hampered the effectiveness of the drug. In adults, treatment with 4 months of rifampin has been shown to be safer and to have higher completion rates than 9 months of isoniazid. METHODS In this multicenter, open‐label trial, we randomly assigned 844 children (<18 years of age) with latent M. tuberculosis infection to receive either 4 months of rifampin or 9 months of isoniazid. The primary outcome was adverse events of grade 1 to 5 that resulted in the permanent discontinuation of a trial drug. Secondary outcomes were treatment adherence, side‐effect profile, and efficacy. Independent review panels whose members were unaware of trial‐group assignments adjudicated all adverse events and progression to active tuberculosis. RESULTS Of the children who underwent randomization, 829 were eligible for inclusion in the modified intention‐to‐treat analysis. A total of 360 of 422 children (85.3%) in the rifampin group completed per‐protocol therapy, as compared with 311 of 407 (76.4%) in the isoniazid group (adjusted difference in the rates of treatment completion, 13.4 percentage points; 95% confidence interval [CI], 7.5 to 19.3). There were no significant between‐group differences in the rates of adverse events, with fewer than 5% of the children in the combined groups with grade 1 or 2 adverse events that were deemed to be possibly related to a trial drug. Active tuberculosis, including 1 case with resistance to isoniazid, was diagnosed in 2 children in the isoniazid group during 542 person‐years of follow‐up, as compared with no cases in the rifampin group during 562 person‐years (rate difference, ‐0.37 cases per 100 person‐years; 95% CI, ‐0.88 to 0.14). CONCLUSIONS Among children under the age of 18 years, treatment with 4 months of rifampin had similar rates of safety and efficacy but a better rate of adherence than 9 months of treatment with isoniazid. (Funded by the Canadian Institutes of Health Research and Conselho Nacional de Pesquisa; ClinicalTrials.gov number, NCT00170209.)
Mental wellbeing in the Anthropocene: Socio-ecological approaches to capability enhancement

There is growing recognition that “human development” frameworks, such as the Capabilities Approach (CA) with its emphasis on the promotion of justice, offer promise for guiding efforts aimed at enhancing mental wellbeing. This article explores challenges that might arise when there is a need to arbitrate among the competing demands of different parties in their efforts to enhance capabilities. Particular tensions can arise when the efforts of particular individuals to enhance their capabilities exert pressure on scarce resources, or threaten the safety and security of people living in precarious environmental contexts. Consideration is given to the need for “an ethos of restraint” to balance the consumption of resources aimed at facilitating human development on the one hand, with the need to promote environmental justice on the other. The paper highlights research that has investigated how environmental factors can impact on mental wellbeing, including rapid urbanization, climate change related issues (such as weather systems, drought, food insecurity and rising sea-levels), and access to “green/blue spaces”. As such, the paper explores the important links that can exist between people and the ecosystems in which they live (including the way in which particular cultural beliefs and practices of indigenous groups can be tethered to the land). Elinor Ostrom’s “design principles”, derived from her work investigating the sustainable use of pooled resources, are presented as a helpful means of assisting members of communities to negotiate and apply “functioning constraints”, which can promote environmental justice whilst not compromising efforts aimed at promoting mental wellbeing.
Lower-Limb Passive Heat Maintenance Combined With Pre-cooling Improves Repeated Sprint Ability

Pre-conditioning strategies to potentiate performance are a common feature of pre-competition routines. The elevation of muscle temperature is seen as a vital component of preparing for physical performance, while pre-cooling strategies have been adopted to offset fatigue during repeated efforts. We investigated the individual and combined effects of a passive heat maintenance strategy and the ingestion of an ice-water slurry on repeated sprint performance. In a random cross-over design, 12 professional male athletes performed 5 × 40 m maximal running sprints under one of four conditions following a standardized warm-up: 15-min passive rest (Control); wearing a lower-body survival garment (HEAT); consuming a 500 mL ice slushy (COLD); or wearing the survival garment and consuming the slushy (H+C). Measures of sprint speed, fatigue, heart rate, and rectal temperature were collected. Compared to COLD: HEAT improved Sprint 1 (ES: 0.84; p = 0.05), but negatively impacted Sprint 4 (ES: -0.87; p = 0.08), and Sprint 5 (ES: -1.57; p = 0.002). H+C was faster than Control for every sprint (ES: 0.28 to 0.66), clearly faster than COLD on Sprints 1–3 (ES: 0.73 to 0.54), and clearly faster than HEAT on Sprints 4 and 5 (ES: 1.31 and 1.87). Fatigue was greatest after the HEAT intervention with a large correlation between fatigue and rectal temperature (r = 0.66; p = 0.0204). While there are undoubtedly peripheral effects of cooling and heating on various aspects of muscle function and fatigue, understanding the integration of psychophysiological homeostatic feedback loops relating to a combined warming and cooling intervention may benefit sports in which repeat sprints are performed.
Permeability Measurements of Thin Sheet Materials and Uncertainty Analysis

In this paper we propose a method to extend the upper frequency range of a commercial test fixture for permeability measurements, especially of thin sheet magnetic materials. Port extensions, de-embedding of a capacitance due to step change of the outer conductor of the fixture and transform of the reflection coefficients with respect to the characteristic impedance other than 50 Ω are used using measured dimensions of the fixture. And to reduce the effect of the permittivity of the sample on the permeability measurement result, air-gap correction technique has been also utilized. A detailed uncertainty analysis of the major contributions has been given also to be used for estimating the measurement uncertainty of the permeability of thin sheet materials.
A Simple Wideband Magnetoelectric Dipole Antenna With a Defected Ground Structure

In this letter, a simple wideband magnetoelectric (ME) dipole antenna with a defected ground structure (DGS) is proposed and investigated. The dimensions of the pair of the quarter-wavelength patch antennas and the half-wavelength electric dipole antennas are changed to extend the impedance bandwidth. A DGS is used for impedance matching, which is novel in the ME dipole antenna design. A prototype of the proposed antenna is designed, fabricated, and measured. On combining impedance bandwidth and radiation pattern, measured results show that the proposed ME dipole antenna achieves an operating bandwidth of 86.9% (1.38–3.5 GHz) for <inline-formula> <tex-math notation="LaTeX">${{\vert S}}_{11}\vert < \hbox{--}{\text {10 dB}}$</tex-math></inline-formula>, and a stable gain of 7.2 ± 1.2 dBi is realized. A low cross-polarization level and low backlobe radiation level are found across the operating bandwidth.