Miracle-dz/UniFAR-FTUs huggingface dataset:
Distinguishing the roles of trait and state anxiety on the nature of anxiety-related attentional biases to threat using a free viewing eye movement paradigm

Although attentional biases to threatening information are thought to contribute to the development and persistence of anxiety disorders, it is not clear whether an attentional bias to threat (ABT) is driven by trait anxiety, state anxiety or an interaction between the two. ABT may also be influenced by “top down” processes of motivation to attend or avoid threat. In the current study, participants high, mid and low in trait anxiety viewed high threat-neutral, mild threat-neutral and positive-neutral image pairs for 5 seconds in both calm and anxious mood states while their eye movements were recorded. State anxiety alone, but not trait anxiety, predicted greater maintenance of attention to high threat images (relative to neutral) following the first fixation (i.e., delayed disengagement) and over the time course. Motivation was associated with the time course of attention as would be expected, such that those motivated to look towards negative images showed the greatest ABT over time, and those highly motivated to look away from negative images showed the greatest avoidance. Interestingly, those ambivalent about where to direct their attention when viewing negative images showed the greatest ABT in the first 500 ms of viewing. Implications for theory and treatment of anxiety disorders, as well as areas for further study, are discussed.
The Prevalence of Xerostomia and Salivary Gland Hypofunction in a Cohort of HIV-positive and At-risk Women

The association of xerostomia and salivary gland hypofunction with HIV infection has been established for men but not for women. We investigated the prevalence of these conditions in a national cohort (n = 733) of HIV-positive and at-risk HIV-negative women. Participants in this prospective cross-sectional study were recruited from the Women's Interagency HIV Study (WIHS) at five outpatient USA clinics. Xerostomia was assessed based on "yes" responses to a dry-mouth questionnaire. Samples of unstimulated whole and chewing-stimulated whole saliva were collected under standardized conditions. The major salivary glands were also evaluated clinically. The prevalence of dry-mouth complaint, the absence of saliva upon palpation, and zero unstimulated whole saliva (flow rate = 0 mL/min) were significantly (p = 0.001) higher in HIV-positive women. Adjusted odds of zero unstimulated whole saliva were significantly (p = 0.02) higher in HIV-positive women vs. HIV-negative women (OR = 2.86; 95% CI, 1.23 to 6.63). Significant (p = 0.03) univariate association was found between zero unstimulated whole saliva and CD4 counts. Adjusted odds of zero unstimulated whole saliva were significantly (p = 0.02) higher for HIV-positive women with CD4 < 200 compared with those with CD4 > 500 (OR = 2.61; 95% CI, 1.17 to 5.85). Chewing-stimulated flow rates were not significantly different between seropositive and seronegative women. The prevalence of xerostomia and salivary gland hypofunction appears to be significantly higher in HIV-positive women relative to a comparable group of at-risk seronegative women. Immunosuppression levels measured by CD4 cell counts are significantly associated with xerostomia and salivary gland hypofunction in a population of HIV-positive women.
Eosinophilic Ulcer of the Tongue - Clinico-Pathological Analysis

Eosinophilic ulcer is an uncommon self limiting lesion, clinically manifest as a solitary ulceration with elevated indurated border affecting the tongue. The etiology remains obscure, although trauma plays a major role. Clinically it closely mimics malignant ulcer and traumatic ulcer cause difficulty in diagnosis and can lead to over diagnosis. Aim to study & discuss a series of cases of eosinophilic ulcer of tongue with a clinicopathological analysis. Ten cases of eosinophilic ulcers were analyzed clinically with a detailed history. H & E stained sections were obtained to of 3-4 µm thickness were obtained to study the detailed histopathology. Patients reported with a pain (8/10) & non healing ulcer (2/10) with a mean age of 52 years & an equal distribution among both the sexes. Solitary ulcers varying in size from 1-3 cms in diameter were seen on the poteriolateral border of tongue with indurated, erythematous margins & existed with the duration from few days to several months. Patient had history of tobacco usage (2/10) & an adjacent sharp cusp tooth (4/10). The provisional diagnosis was either traumatic ulcer or malignancy. Incisional biopsy wa s performed & histopathological examination revealed an ulcerated epithelium and inflammatory infiltrate comprised of lymphocytes, histiocytes and predominantly eosinophils in the stoma. The inflammatory cells extended deep into the muscle fibers. Eosinophilic ulcer was confirmed. None of the patients reported & uneventful healing was seen within 1-2 months. Eosinophilic ulcer is a histopathological diagnosis; biopsy helps to confirm and also aids in differentiate it from other lesions ranging from reactive, granulomatous to malignancy.
A placebo-controlled study of high dose buprenorphine in opiate dependents waiting for medication-assisted rehabilitation in Oslo, Norway.

AIMS To evaluate whether buprenorphine. even without additional control and psychosocial treatment and support, alleviates the problems faced by patients waiting for medication assisted rehabilitation (MAR). DESIGN A randomized, double-blind, 12-week study of Subutex versus placebo without additional support as an interim therapy. PARTICIPANTS One hundred and six patients, 70 males and 36 females, waiting for MAR in Oslo. The average age was 38 years with an average history of heroin use of 20 years. Fifty-five patients were assigned to buprenorphine and 51 to a placebo. INTERVENTION Subutex or placebo sublingual tablets were given under supervision in a daily dose of 16 mg with the exception of a double dose on Saturday and no dose on Sunday. MEASUREMENT Retention, compliance, self-reported drug-abuse, wellbeing and mental health. FINDINGS The average number of days of participation was significantly higher in the buprenorphine group, 42 (median: 29) compared to 14 (median: 11) for the placebo group (P < 0.001). The retention of patients after 12 weeks was 16 patients in the buprenorphine group and one patient in the placebo group. The buprenorphine group had a larger decrease in reported opioid use (p < 0.001) and in reported use of other drugs, tablets and alcohol abuse (p < 0.01). The group also showed a stronger increase in wellbeing (p < 0.01) and life satisfaction (p < 0.05). None of the participants died. CONCLUSION The patients waiting for MAR benefited significantly from the buprenorphine as an interim therapy according to retention, self-reported use of drugs and wellbeing. However, the patients had difficulties in remaining in treatment over time without psychosocial support.
Who's really hypertensive? – Quality control issues in the assessment of blood pressure for randomized trials

The characterization of blood pressure in treatment trials assessing the benefits of blood pressure lowering regimens is a critical factor for the appropriate interpretation of study results. With numerous operators involved in the measurement of blood pressure in many thousands of patients being screened for entry into clinical trials, it is essential that operators follow pre‐defined measurement protocols involving multiple measurements and standardized techniques. Blood pressure measurement protocols have been developed by international societies and emphasize the importance of appropriate choice of cuff size, identification of Korotkoff sounds, and digit preference. Training of operators and auditing of blood pressure measurement may assist in reducing the operator‐related errors in measurement. This paper describes the quality control activities adopted for the screening stage of the 2nd Australian National Blood Pressure Study (ANBP2). ANBP2 is cardiovascular outcome trial of the treatment of hypertension in the elderly that was conducted entirely in general practices in Australia. A total of 54 288 subjects were screened; 3688 previously untreated subjects were identified as having blood pressure >140/90 mmHg at the initial screening visit, 898 (24%) were not eligible for study entry after two further visits due to the elevated reading not being sustained. For both systolic and diastolic blood pressure recording, observed digit preference fell within 7 percentage points of the expected frequency. Protocol adherence, in terms of the required minimum blood pressure difference between the last two successive recordings, was 99.8%. These data suggest that adherence to blood pressure recording protocols and elimination of digit preferences can be achieved through appropriate training programs and quality control activities in large multi‐centre community‐based trials in general practice. Repeated blood pressure measurement prior to initial diagnosis and study entry is essential to appropriately characterize hypertension in these elderly patients.
Photovoltaic parameter estimation using Grey Wolf Optimization

Photovoltaic model has a high reliability and precision are essential in performing simulated power system of photovoltaic (PV). In this study, PV modeled using Ideal Single Diode Model (ISDM). The parameters of the ISDM must be estimated accurately to obtain reliable models. To determine the model parameters easily, one of the parameters must be assumed. This is due to the limited information from the datasheet issued by the manufacturer of PV. This study proposes a parameterization approach for ISDM of PV, thus increasing the accuracy of the model reduces complexity by using Grey Wolf Optimization (GWO). GWO estimate the parameters ISDM accurately, thereby increasing the accuracy of the model by using the manufacturer's datasheet. The simulation results show the maximum power simulation equal with maximum power datasheet 74.80W for Shell SP75 at ideally diode factor A = 2.058 and maximum power simulation 230.19 W proportional with maximum power datasheet 230.20 W for SST230-60P at ideally diode factor A = 1.888. The simulation results precise for ISDM-three parameters to obtain the maximum power value simulation results compare to the maximum electric power from the manufacturer's data sheet.
H-Channels and Seizures: Less is More

Seizure-induced Plasticity of h Channels in Entorhinal Cortical Layer III Pyramidal Neurons Shah MM, Anderson AE, Leung V, Lin X, Johnston D Neuron 2004;44:495–508 The entorhinal cortex (EC) provides the predominant excitatory drive to the hippocampal CA1 and subicular neurons in chronic epilepsy. Discerning the mechanisms underlying signal integration within EC neurons is essential for understanding network excitability alterations involving the hippocampus during epilepsy. Twenty-four hours after a single seizure episode when no behavioral or electrographic seizures occurred, we found enhanced spontaneous activity still present in the rat EC in vivo and in vitro. The increased excitability was accompanied by a profound reduction in Ih in EC layer III neurons and a significant decline in hyperpolarization-activated cation (HCN)1 and HCN2 subunits that encode for h channels. Consequently, dendritic excitability was enhanced, resulting in increased neuronal firing despite hyperpolarized membrane potentials. The loss of Ih and the increased neuronal excitability persisted for 1 week after seizures. Our results suggest that dendritic Ih plays an important role in determining the excitability of EC layer III neurons and their associated neural networks.
Seroprevalence and GIS-supported risk factor analysis of Fasciola hepatica infections in dairy herds in Germany

SUMMARY A total of 20 749 bulk tank milk (BTM) samples was collected in November 2008 from all over Germany, corresponding to 20·9% of all German dairy herds. The BTM samples were analysed for antibodies against Fasciola hepatica using the excretory–secretory (ES) ELISA. A geospatial map was drawn to show herd prevalences per postal code area. Various spatial risk factors were tested for potential statistical associations with the ELISA results in logistic regression supported by a geographical information system (GIS). The mean seroprevalence was 23·6% and prevalences in different German federal states varied between 2·6% and 38·4%. GIS analysis revealed statistically significant positive associations between the proportion of grassed area and water bodies per postal code area and positive BTM ELISA results. This can be explained by the biology of the intermediate host, the amphibious snail Galba (Lymnea) truncatula and the pasture-borne nature of fasciolosis. The full logistic regression model had a Pseudo-R2 of 22%, while the final model obtained by controlled stepwise model building revealed a Pseudo-R2 of 14%, indicating that additional, unrecorded factors and random effects contributed substantially to the occurrence of positive ELISA results. Considering the high seroprevalences in some areas and the economic impact of fasciolosis, farmers and veterinarians should be strongly advised to implement effective liver fluke control programmes.
Glutamine enhancement of structure and function in transplanted small intestine in the rat.

Total parenteral nutrition is required by all patients in need of small bowel transplantation. Untoward side effects of total parenteral nutrition include atrophy and hypofunction of the small intestine. Glutamine, the preferred fuel for the enterocyte, is presumably present in insufficient amounts in diets given to patients with intestinal dysfunction. In a rat model of total parenteral nutrition and small bowel transplantation, this study investigated the following: (1) whether glutamine improves graft structure and function, (2) the optimal route of glutamine delivery (intravenous vs direct infusion into the graft), and (3) the effect of glutamine on ultrastructure of the graft enterocyte. Lewis rats underwent small bowel transplantation as a Thiry-Vella graft and received total parenteral nutrition for 14 days while assigned to one of four infusion groups: 2% intravenous glutamine; 2% intravenous isonitrogenous mixture, nonessential amino acids (control); 2% glutamine into the graft; or 2% nonessential amino acids into the graft (control). Graft mucosal villous height, villous surface area, crypt depth, weight, protein, deoxyribonucleic acid content, glucose absorption, and enterocyte ultrastructure were then evaluated. Infusion of glutamine directly into the graft significantly increased mucosal villous height (p = .045), surface area (p = .029), and glucose absorption (p = .004) when compared with controls. Intravenous glutamine infusion significantly increased mucosal villous height (p = .002), surface area (p = .001), weight (p = .005), and glucose absorption (p = .04) when compared with controls. Most enterotrophic and functional benefits of glutamine were not significantly different between intravenous infusions and direct administration into the graft. (ABSTRACT TRUNCATED AT 250 WORDS)
Estimation of dental age and its comparison with chronological age: accuracy of two radiographic methods

Introduction Accurate age data are always necessary in medicine and dentistry, and are also important to assess maturity and estimate age in a number of disciplines, such as forensic odontology, paediatric and preventive dentistry, orthodontics, etc. Aim This investigation determines the accuracy of dental age estimation and its comparison with chronological age by two methods: Demirjian's and Willems’. Materials and methods Tooth development was assessed in seven left mandibular teeth from 215 orthopantomograms (OPGs) belonging to healthy children aged 6–15 years selected by convenience sampling, from patients of the Sudha Rustagi College of Dental Sciences & Research, Faridabad, and were staged according to Demirjian's and Willems’ scales. The statistical analysis was performed using the unpaired ‘t’-test and the correlation was analysed using Karl Pearson's correlation coefficients test. Results Overall, Willems’ method was found to be more accurate with a mean age overestimation of 0.36 years (SD = 0.38) in boys and 0.24 years (SD = 0.36) in girls, and Demirjian's method produced a mean overestimation of 0.66 years (SD = 0.41) in boys and 0.56 years (SD = 0.43) in girls, respectively. Also, correlation between the two methods revealed a high coefficient value, 0.9947 for boys and 0.9944 for girls (P < 0.05). Conclusion Despite the favourable result of Willems’ method in comparison with Demirjian's method, this study demonstrated a high correlation coefficient between both chronological and obtained dental age, thus confirming their potential applicability in clinical practice and forensic dentistry.
Extended Deterministic Mean-Field Games

In this paper, we consider mean-field games where the interaction of each player with the mean field takes into account not only the states of the players but also their collective behavior. To do so, we develop a random variable framework that is particularly convenient for these problems. We prove an existence result for extended mean-field games and establish uniqueness conditions. In the last section, we consider the Master Equation and discuss properties of its solutions.
Thin-layer convective drying behaviour of brazilian peppertree leaves

: Studies on the drying kinetics of medicinal, aromatic and spice plants are a necessary step towards establishing the combination of drying parameters that would not qualitatively and quantitatively alter the quality of the fresh product. The purpose of this study was to investigate the drying kinetics of Brazilian peppertree ( Schinus terebinthifolius ) leaves and to verify whether the theoretical diffusion and the semi-empirical Lewis drying models were capable of accurately predicting the drying curves of the product at 35, 40, and 45°C, with a dry air mass flow rate of 0.731 kg s -1 m -2 . Leaves were collected at 0800 h, 1200 h and 1700 h. The goodness of fit between experimental and predicted values was based on the correlation coefficient, root mean square error, mean absolute percentage error, mean bias error, and fit index. Residual plot analysis was also considered in the selection of the most effective drying model. Temperature had a pronounced effect on mass transfer and drying rate decreased continuously during the course of drying. Leaf collection time had little influence on the drying kinetics. Effective moisture diffusivity was found to increase with temperature. The results indicated that the Lewis model was considered a better predictor of the thin-layer drying behaviour of Brazilian peppertree leaves than the theoretical model based on Fick’s second law of diffusion.
Female Repeat Offenders Negotiating Identity

This study examines the process of identity negotiation for Israeli female ex-convicts who were separated for extensive periods of time from their children and eventually lost custody over them. The content analysis of in-depth interviews reveals that these women were able to reconstruct their biographies and retrospectively account for their crimes and drug addiction in terms of the sexual, physical, and economic abuse they had endured and by appeal to higher loyalties, their children who they had to provide for. However, when having to account for their failings as mothers, all biographical reconstruction, external blame, and accusation collapsed. Looking at themselves through their children's eyes, female offenders were simply unable to renegotiate the imputed identity of incompetent mother. They could neither confront their children's anger nor explain to them why they had abandoned them. Permanently alienated from the center of motherhood, these women were doomed to an existential chaos.
Characteristics of Shale Reservoir and Sweet Spot Identification of the Lower Cambrian Niutitang Formation in Northwestern Hunan Province, China

The accumulation and productivity of shale gas are mainly controlled by the characteristics of shale reservoirs; study of these characteristics forms the basis for the shale gas exploitation of the Lower Cambrian Niutitang Formation (Fm), Southern China. In this study, core observation and lithology study were conducted along with X‐ray diffraction (XRD) and electronic scanning microscopy (SEM) examinations and liquid nitrogen (N2) adsorption/desorption and CH4 isothermal adsorption experiments for several exploration wells in northwestern Hunan Province, China. The results show that one or two intervals with high‐quality source rocks (TOC>2 wt%) were deposited in the deep‐shelf facies. The source rocks, which were mainly composed of carbonaceous shales and siliceous shales, had high quartz contents (>40 wt%) and low clay mineral (<30 wt%, mainly illites) and carbonate mineral (<20 wt%) contents. The SEM observations and liquid nitrogen (N2) adsorption/desorption experiments showed that the shale is tight, and nanoscale pores and microscale fractures are well developed. BJH volume (VBJH) of shale ranged from 2.144×10–3 to 20.07×10–3 cm3/g, with an average of 11.752×10–3 cm3/g. Pores mainly consisted of opened and interconnected mesopores (2–50 nm in diameter) or macropores (>50 nm in diameter). The shale reservoir has strong adsorption capacity for CH4. The Langmuir volume (VL) varied from 1.63 to 7.39 cm3/g, with an average of 3.95 cm3/g. The characteristics of shale reservoir are controlled by several factors: (1) A deep muddy continental shelf is the most favorable environment for the development of shale reservoirs, which is controlled by the development of basic materials. (2) The storage capacity of the shale reservoir is positively related to the TOC contents and plastic minerals and negatively related to cement minerals. (3) High maturity or overmaturity leads to the growth of organic pores and microfractures, thereby improving the reservoir storage capacity. It can be deduced that the high percentage of residual gas in Niutitang Fm results from the strong reservoir storage capacity of adsorbed gas. Two layers of sweet spots with strong storage capacity of free gas, and they are characterized by the relatively high TOC contents ranging from 4 wt% to 8 wt%.
Measuring the hospital practice environment: a Canadian context.

The primary purpose of this study is to document the psychometric properties of the revised Nursing Work Index (NWI-R) in the context of a large Canadian sample of registered nurses. A self-administered survey containing the NWI-R was completed by 17,965 registered nurses working in 415 hospitals in three Canadian provinces. Using exploratory principal components analysis, with a forced one-factor solution, the practice environment index was obtained. In addition, key assumptions were tested from previous work about the rationale for the aggregation of NWI-R responses. In the Canadian context the one-factor solution provides a parsimonious index of the practice environment of registered nurses working in acute care hospitals. Further work is needed to determine the predictive capability of this index and its relevance to cross-national organizational contexts.