Miracle-dz/UniFAR-FTUs huggingface dataset:
Intratumor distribution of 1p deletions in human colorectal adenocarcinoma is Commonly homogeneous

Cytogenetics and molecular biology studies have indicated that a large subset of human colorectal adenocarcinomas have distal 1p chromosome arm deletions. The aim of this study was to evaluate the intratumor distribution of 1p deletions under the assumption that homogeneity is an indication of early occurrence.
Metamaterial structures based on ‘Negative’ elements what do we know after a decade of research?

Almost ten years have passed since the first experimental attempts of enhancing functionality of metamaterials by inclusion of active ‘negative’ elements. This paper reviews aforementioned research field, giving an emphasis on unclear issues such as connection between causality, stability, and non-linearity. Finally, some future trends that apply non-linearity and instability of negative elements, are highlighted.
Predictors of major bleeding in peri‐procedural anticoagulation management

Summary. Background: Appropriate periprocedural management for chronically anticoagulated patients requires assessment of patient‐specific thrombosis and bleeding risks. However, predictors of post‐procedure bleeding are unknown. Objectives: To determine the 3‐month cumulative incidence and independent predictors of peri‐procedural bleeding in chronically anticoagulated patients requiring temporary warfarin interruption for an invasive procedure. Methods: In a protocol driven, cohort study design, all patients referred to the Mayo Clinic Thrombophilia Center for peri‐procedural anticoagulation management (1997–2007; n = 2182), were followed forward in time to determine the 3‐month cumulative incidence of peri‐procedural bleeding (Kaplan–Meier product limit) and potential predictors of bleeding (Cox proportional hazards). Decisions to ‘bridge’ with low‐molecular‐weight heparin were based on estimated thromboembolism and bleeding risk. Results: Indications for chronic anticoagulation included venous thromboembolism (38%), atrial fibrillation (30%) and mechanical heart valves (27%). Of these, 1496 (69%) patients received bridging therapy. The 3‐month cumulative incidence rates of major and overall bleeding were 2.1% and 5.1%, respectively. Major bleeding occurred more frequently in patients receiving bridging therapy (3% vs. 1%; P = 0.017). Independent predictors (hazard ratio; 95% confidence interval) of major bleeding included mitral mechanical heart valve (2.2; 1.1–4.3), active cancer (1.8; 1.0–3.1), prior bleeding history (2.6; 1.5–4.5) and re‐initiation of heparin therapy within 24 h after the procedure (1.9; 1.1–3.4). Conclusion: Factors predisposing to peri‐procedural bleeding are primarily patient‐specific. Premature heparin re‐initiation is an avoidable provider‐specific variable to consider.
Precision Farming at the Nexus of Agricultural Production and the Environment

Precision farming enables agricultural management decisions to be tailored spatially and temporally. Site-specific sensing, sampling, and managing allow farmers to treat a field as a heterogeneous entity. Through targeted use of inputs, precision farming reduces waste, thereby cutting both private variable costs and the environmental costs such as those of agrichemical residuals. At present, large farms in developed countries are the main adopters of precision farming. But its potential environmental benefits can justify greater public and private sector incentives to encourage adoption, including in small-scale farming systems in developing countries. Technological developments and big data advances continue to make precision farming tools more connected, accurate, efficient, and widely applicable. Improvements in the technical infrastructure and the legal framework can expand access to precision farming and thereby its overall societal benefits.
Fluid Intelligence Predicts Novel Rule Implementation in a Distributed Frontoparietal Control Network

Fluid intelligence has been associated with a distributed cognitive control or multiple-demand (MD) network, comprising regions of lateral frontal, insular, dorsomedial frontal, and parietal cortex. Human fluid intelligence is also intimately linked to task complexity, and the process of solving complex problems in a sequence of simpler, more focused parts. Here, a complex target detection task included multiple independent rules, applied one at a time in successive task epochs. Although only one rule was applied at a time, increasing task complexity (i.e., the number of rules) impaired performance in participants of lower fluid intelligence. Accompanying this loss of performance was reduced response to rule-critical events across the distributed MD network. The results link fluid intelligence and MD function to a process of attentional focus on the successive parts of complex behavior. SIGNIFICANCE STATEMENT Fluid intelligence is intimately linked to the ability to structure complex problems in a sequence of simpler, more focused parts. We examine the basis for this link in the functions of a distributed frontoparietal or multiple-demand (MD) network. With increased task complexity, participants of lower fluid intelligence showed reduced responses to task-critical events. Reduced responses in the MD system were accompanied by impaired behavioral performance. Low fluid intelligence is linked to poor foregrounding of task-critical information across a distributed MD system.
Common polymorphisms in the interleukin-6 gene and myocardial infarction risk: a meta-analysis.

BACKGROUND Interleukin-6 (IL-6) plays a critical role in the development and progression of cardiovascular disease. Emerging evidence suggests that two common polymorphisms (-174 G/C and -572 G/C) in the IL-6 gene might have an impact on an individual's susceptibility to myocardial infarction (MI), but individually published results are inconclusive. This meta-analysis aimed to derive a more precise estimation of the relationship between IL-6 -174 G/C and -572 G/C polymorphisms and MI risk. METHOD An extensive literary search for relevant studies was conducted in PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases from their inception through August 1st, 2013. A meta-analysis was then performed using the STATA 12.0 software. The crude odds ratios (OR) with 95% confidence intervals (CI) were calculated. RESULTS Eleven case-control studies were included with a total of 10,252 subjects, including 5429 MI patients and 4823 healthy controls. Our meta-analysis results indicated that IL-6 -174 G/C polymorphism may increase the risk of MI (C allele vs. G allele: OR=1.07, 95% CI: 1.01-1.14, p=0.018; GC+CC vs. GG: OR=1.14, 95% CI: 1.04-1.24, p=0.003; respectively). However, our results showed no significant association between IL-6 -572 G/C polymorphism and MI risk (C allele vs. G allele: OR=0.88, 95% CI: 0.75-1.03, p=0.098; GC+CC vs. GG: OR=0.87, 95% CI: 0.70-1.07, p=0.173; respectively). No publication bias was detected in this meta-analysis. CONCLUSION The current meta-analysis suggests that IL-6 -174 G/C polymorphism may contribute to MI susceptibility. Thus, detection of IL-6 -174 G/C polymorphisms may be a promising biomarker for the early detection of MI. However, IL-6 -572 G/C polymorphism may not associate with the risk of MI.
Representation of complex terms in a vector space structured by an ontology for a normalization task

We propose in this paper a semi-supervised method for labeling terms of texts with concepts of a domain ontology. The method generates continuous vector representations of complex terms in a semantic space structured by the ontology. The proposed method relies on a distributional semantics approach, which generates initial vectors for each of the extracted terms. Then these vectors are embedded in the vector space constructed from the structure of the ontology. This embedding is carried out by training a linear model. Finally, we apply a distance calculation to determine the proximity between vectors of terms and vectors of concepts and thus to assign ontology labels to terms. We have evaluated the quality of these representations for a normalization task by using the concepts of an ontology as semantic labels. Normalization of terms is an important step to extract a part of the information containing in texts, but the vector space generated might find other applications. The performance of this method is comparable to that of the state of the art for this task of standardization, opening up encouraging prospects.
Development of a system for clinical evaluation of the biotin status of sows.

Sixteen test gilts were fed an egg white-fortified practical diet and four control gilts an egg white-free diet over a two-parity period in order to monitor changes in the serum biotin levels as induced biotin deficiency progressed. Gilts were individually housed in metal crates with slatted floors. Serum biotin (ng/L) of test animals declined from 1490 (initially) to 610 (month 3), remained stable (months 4-8) and thereafter approached 400, 135 and 30 after months 9, 13 and 15, respectively. Early clinical symptoms, i.e. lesions (on the feet, legs and skin), hoof cracks, hair loss and dry skin, were first observed after six months and became progressively more pronounced with time. After nine months, the induced symptoms resembled those characteristic of biotin deficiency. In contrast, serum biotin remained high in the control animals which did not develop symptoms. The data are interpreted to mean that serum biotin might be used as a sensitive index of biotin deficiency development in sows. On the basis of these observations, a system is proposed for evaluation of the sow's biotin status. Adequate biotin may be indicated by serum biotin level (ng/L) > 700; marginal, > 600 < 700; inadequate, > 400 < 600; and deficient, < 400. Alternatively, several concurrent clinical symptoms (i.e. alopecia, hoof cracks and lesions on the feet, legs and skin) may aid in the diagnosis of inadequate biotin status of sow herds reared under field conditions.
Global Ischemia Induces Expression of Acid-Sensing Ion Channel 2a in Rat Brain

Acid-sensing ion channels (ASICs) are ligand-gated cation channels that respond to acidic stimuli. They are expressed throughout the mammalian nervous system. In the peripheral nervous system, ASICs act as nociceptors, responding to the tissue acidosis that accompanies ischemic and inflammatory conditions. The function of ASICs in the central nervous system is not known. In this article, the authors present evidence that transient global ischemia induces ASIC 2a protein expression in neurons that survive ischemia. Western blot analysis with an anti-ASIC 2a antibody revealed up-regulation of an 80 kD protein in ischemic rat brain. Immunohistochemical analysis showed that ASIC 2a protein expression increased in neurons of the hippocampus and cortex. Klenow fragment-mediated labeling of DNA strand breaks determined that ASIC 2a induction did not occur in cells with detectable DNA damage. The current results suggest a possible role for ASICs in mediating a cellular response to ischemia.
Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine*

Objectives:Because several experimental studies have demonstrated that cyclic adenosine monophosphate generation following β-adrenoceptor activation can markedly stimulate alveolar fluid clearance, we determined whether the endogenous levels of catecholamines that occur in the pulmonary edema fluid and plasma of patients with acute lung injury are high enough to stimulate alveolar fluid clearance in the human lung. Design:Observational clinical study. Setting:Academic university hospital and laboratory. Patients:Twenty-one patients with acute pulmonary edema plus ex vivo human lungs. Interventions:Measurements of catecholamine levels in patient samples and controlled laboratory studies of the effects of these catecholamine levels on the rates of alveolar fluid clearance in ex vivo human lungs. Measurements and Main Results:The concentrations of both epinephrine and norepinephrine in the pulmonary edema fluid and plasma were ∼10−9 M (range of 1–8 × 10−9 M) in hydrostatic pulmonary edema (n = 6) and acute lung injury patients (n = 15). We therefore tested whether 10−9 M epinephrine or norepinephrine stimulated alveolar fluid clearance in isolated human lungs and found that these epinephrine or norepinephrine concentrations did not stimulate alveolar fluid clearance. However, higher concentrations of epinephrine (10−7 M), but not norepinephrine (10−7 M), significantly stimulated alveolar fluid clearance by 84% above control. Glibenclamide (10−5 M) and CFTRinh-172 (10−5 M), cystic fibrosis transmembrane conductance regulator inhibitors, completely inhibited the epinephrine-induced stimulation of alveolar fluid clearance. Conclusions:These results indicate that endogenous catecholamine concentrations in pulmonary edema fluid are probably not sufficient to stimulate alveolar fluid clearance. In contrast, administration of exogenous catecholamines into the distal airspaces can stimulate alveolar fluid clearance in the human lung, an effect that is mediated in part by cystic fibrosis transmembrane conductance regulator. Therefore, exogenous cyclic adenosine monophosphate-dependent stimulation will probably be required to accelerate the resolution of alveolar edema in the lungs of patients with pulmonary edema.
Professional identity and nursing: contemporary theoretical developments and future research challenges.

AIM We propose that the conceptual orientation of professional identity is a logical consequence of self-concept development by focusing on career and its meaning and presents a measurable set of concepts that can be manipulated to improve retention of student and registered nurses within health service. BACKGROUND Although professional identity is a term that is commonly written of in nursing literature, its theoretical origins remain unclear, and available empirical evidence of its presence or ability to change is omitted from nursing research. SOURCES OF EVIDENCE: We present a professional identity pathway and explore the factors that influence professional identity throughout a career in nursing. DISCUSSION Nurses' professional identities develop throughout their lifetimes, from before entering nursing education, throughout their years of study and clinical experience, and continue to evolve during their careers. Education is, however, a key period as it is during this time students gain the knowledge and skills that separate nurses as professional healthcare workers from lay people. CONCLUSION Finally, a call for longitudinal studies of students to graduates, using conceptually derived and psychometrically proven instruments capable of detecting the subtle changes in the construct over time, is recommended. Further empirical research into the theoretical concepts that underline professional identity, and the factors that influence changes in this important construct in nursing, is required. Ultimately, the practical relevance of such research will lie in the potential it provides for enhanced nursing career support and improved workforce policies.
Multiplicity of peptide permeases in Candida albicans: evidence from novel chromophoric peptides

Evidence is presented for the presence of multiple peptide permeases in the eucaryotic organism Candida albicans. Instrumental in these studies were the peptides L-alanyl-L-2-thiophenylglycine (Ala-alpha-TPG) and L-alanyl-L-2-thiophenylglycyl-L-alanine (Ala-alpha-TPG-Ala), which contain thiophenol attached to the alpha-carbon of glycine. Subsequent to transport into the fungal cell, enzymatic hydrolysis of these peptides resulted in the release of free thiophenol, which was quantified by using Ellman reagent. Thiophenol release was shown to be directly correlated to peptide transport and hydrolysis, with transport being the rate-limiting step in intact cells. These peptides, whose uptake showed Michaelis-Menten kinetics, have been used to determine peptide uptake in C. albicans. In addition, we found that the intracellular peptidases can readily be assayed in permeabilized cells and that bestatin, an aminopeptidase inhibitor, inhibits all detectable peptidase activity. C. albicans 124 was able to transport and hydrolyze both Ala-alpha-TPG and Ala-alpha-TPG-Ala, whereas the mutant (124NIK5) was able to transport only the tripeptide. The intracellular peptidases of this mutant were unaffected. In wild-type C. albicans 124, oligopeptides were able to compete with uptake of Ala-alpha-TPG-Ala to a far greater extent than with that of Ala-alpha-TPG; dipeptides inhibited uptake of both Ala-alpha-TPG and Ala-alpha-TPG-Ala. These results provide complementary evidence for the existence of distinct transport systems.
A Multi-Factor Strategy for Index Alpha Enhancement

Empirical studies suggest that the so-called “low volatility anomaly” is actually an artifact of skewness preferences—a tendency of investors to prefer stocks offering upside potential with low likelihood of loss. The authors argue that if skewness preferences underlie the low volatility anomaly, then a naïve low volatility strategy should be dominated by one that explicitly targets expected return skew. This article provides empirical evidence to that effect. It recommends a multi-factor alpha strategy that is based on avoiding index constituents that are perceived to have ex ante high relative skew. These findings have important implications for investors. Specifically, the authors demonstrate that portfolios constructed to avoid high expected skew stocks outperform both low volatility strategies and several widely used US and global capitalization-weighted indices.
Exchange rate impact on output and inflation: A historical perspective from Zimbabwe

This research looks at the inflationary effect of currency devaluation and its contractionary effect on real output growth in Zimbabwe. The study uses quarterly data from 1990 to 2006 and utilizes the Johansen co-integration regression test and vector error correction method (VECM); and examines the short run and long run relationship between exchange rate, inflation and real output. The study finds that firstly, in both the short run and long run, fluctuations in the real exchange rate are significant on real output growth and expansionary in both periods. Secondly, the findings of the study suggest that exchange rate fluctuations are neither inflationary nor deflationary in Zimbabwe in the short run. Lastly, the result of the long run supports our hypothesis that devaluation of real exchange rate is inflationary. It implies that the weakening of domestic currency as part of the exchange rate liberalization policy is an incentive to Zimbabwean exporters and has potential economic growth gains though, in the long run, it has inflationary effects.
Postresuscitation syndrome: Potential role of hydroxyl radical-induced endothelial cell damage*

Objective:After out of hospital cardiac arrest, it has been reported that endothelium dysfunction may occur during the postresuscitation syndrome. However, the consequences of the reperfusion phase on endothelial reactive oxygen species production and redox homeostasis have not been explored in out of hospital cardiac arrest patients. Design:Prospective, observational study. Setting:Medical intensive care unit in a university hospital. Patients:Twenty successfully resuscitated out of hospital cardiac arrest patients, seven septic shock patients, and ten healthy volunteers. Intervention:Plasma was collected from patients at admission and 12, 24, 36, 48, and 72 hrs after cardiac arrest. We studied the production of reactive oxygen species and cell survival during plasma perfusion using perfused endothelial cells (human umbilical vein endothelial cells) as a model. Cell antioxidant response was studied by measuring superoxide dismutase, glutathione peroxidase, and glutathione reductase activities and reduced and oxidized glutathione levels. Mitochondrial respiratory chain activity was assessed by measuring complex I, II, III, and IV activities and anaerobic glycolysis by measuring glucose-6-phosphate dehydrogenase activity. Measurements and Main Results:Using perfused endothelial cells as a model, we demonstrate that plasma from out of hospital cardiac arrest patients induced on naive human umbilical vein endothelial cells a significant and massive cell death compared to plasma from septic shock patients and healthy volunteers. An increase of reactive oxygen species production with a decrease in antioxidant defenses (superoxide dismutase, glutathione peroxidase, and glutathione reductase activities, reduced and oxidized glutathione levels) was observed. The metabolic consequence of plasma exposure showed that mitochondrial respiratory chain activity was significantly impaired and anaerobic glycolysis was significantly increased. Inhibiting hydroxyl radical production significantly decreased cell death, suggesting that plasma from out of hospital cardiac arrest induced significant cell death by triggering the Fenton reaction. Conclusion:Plasma from out of hospital cardiac arrest induces major endothelial toxicity with an acute pro-oxidant state in the cells and impairment of mitochondrial respiratory chain activity. This toxicity could be due to hydroxyl radical production by activation of the Fenton reaction.
Hybrid Parallelization of Standard Full Tableau Simplex Method with MPI and OpenMP

The simplex method has been successfully used in solving linear programming problems for many years. Parallel approaches have also extensively been studied due to the intensive computations required, especially for the solution of large linear problems (LPs). In this paper we present a highly scalable implementation framework of the standard full tableau simplex method on a hybrid parallel environment, which consists of multiple multicore processing nodes interconnected via a high-speed communication network. Specifically, we have designed and implemented a suitable column-based distribution scheme, following three different parallelization models: (a) pure MPI (one MPI process on each core), (b) hybrid OpenMP-based (OpenMP constructs used for parallelization over the cores of each node), and (c) hybrid MPI-based (MPI 3.0 shared memory functions used for parallelization over the cores of each node). We then compare our approaches (i) among each other for variable number of nodes/cores and problem size, and (ii) to other recent and valuable corresponding efforts in the literature. In all cases the hybrid OpenMP-based parallelization scheme performs quite/much better than the other two schemes. Moreover, all the three parallelization schemes lead to particularly high speed-up and efficiency values, whereas the corresponding values for the OpenMP-based scheme are considerably better than the ones achieved in other similar research efforts and implementations.