Miracle-dz/UniFAR-FTUs huggingface dataset:
Interactions of quinoxaline antibiotic and DNA: the molecular structure of a triostin A-d(GCGTACGC) complex.

The crystal structure of a DNA octamer d(GCGTACGC) complexed to an antitumor antibiotic, triostin A, has been solved and refined to 2.2 A resolution by x-ray diffraction analysis. The antibiotic molecule acts as a true bis intercalator surrounding the d(CpG) sequence at either end of the unwound right-handed DNA double helix. As previously observed in the structure of triostin A-d(CGTACG) complex (A.H.-J. Wang, et. al., Science, 225, 1115-1121 (1984)), the alanine amino acid residues of the drug molecule form sequence-specific hydrogen bonds to guanines in the minor groove. The two central A.T base pairs are in Hoogsteen configuration with adenine in the syn conformation. In addition, the two terminal G.C base pairs flanking the quinoxaline rings are also held together by Hoogsteen base pairing. This is the first observation in an oligonucleotide of. Hoogsteen G.C base pairs where the cytosine is protonated. The principal functional components of a bis-intercalative compound are discussed.
Natural abundance of 13C and 15N in C3 and C4 vegetation of southern Africa: patterns and implications

The mean annual rainfall in southern Africa is found to explain over half of the observed variance in the stable nitrogen (N) isotopic signatures of C3 vegetation in southern Africa (r2=0.54, P<0.01). The inverse relationship between the stable N isotopic signatures of foliar samples from C3 vegetation and long‐term southern African rainfall is found on a scale larger than previously observed. A modest relationship is found between stable carbon (C) isotopic signatures of C3 vegetation and rainfall across the region (r2=0.20, P<0.01). No such relationship is found between stable C and N isotopic signatures of C4 vegetation and rainfall. The explanation of the relationship between 15N in C3 vegetation and the mean annual rainfall presented here is that nutrient availability varies inversely with water availability. This suggests that water‐limited systems in southern Africa are more open in terms of nutrient cycling and therefore the resulting natural abundance of foliar 15N in these systems is enriched. The use of this relationship may be of value to those researchers modeling both the dynamics of vegetation and biogeochemistry across this region. The use of the isotopic enrichment in C3 vegetation as a function of rainfall may provide an insight into nutrient cycling across the semi‐arid and arid regions of southern Africa. This finding has implications for the study of global change, especially as it relates to vegetation responses to changing regional rainfall regimes over time.
Source Consultancy and Information Utilization Behavior among Ginger Growers

Ginger is one of the earliest known oriental spices and is being cultivated in India for both as fresh vegetable and as a dried spice, since time immemorial. Ginger is obtained from the rhizomes of Zingiber officinale. The ginger family is a tropical group, especially abundant in Indo-Malaysian region, consisting of more than 1200 plant species in 53 genera. The total production of ginger in the world is 1683.00 thousand tons with the total acreage of 310.43 thousand ha. China, India, Nepal and Thailand are the major producers of ginger in the world, having production of 396.60 thousand tons, 385.33 thousand tons, 210.79 thousand tons and 172.68 thousand tons respectively. India and Indonesia have the largest area under cultivation. The area under cultivation in India is 107.54 thousand ha and International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 06 (2018) Journal homepage: http://www.ijcmas. com
Design, scope and focus of safety recommendations: results from aviation safety investigations

Abstract Literature and industry standards do not mention inclusive guidelines to generate safety recommendations. Following a literature review, we suggest nine design criteria as well as the classification of safety recommendations according to their scope (i.e. organizational context, stakeholders addressed and degree of change) and their focus, the latter corresponding to the type of risk barrier introduced. The design and classification criteria were applied to 625 recommendations published by four aviation investigation agencies. The analysis results suggested sufficient implementation of most of the design criteria. Concerning their scope, the findings showed an emphasis on processes and structures (i.e. lower organizational contexts), adaptations that correspond to medium degree of changes, and local stakeholders. Regarding the focus of the recommendations, non-technical barriers that rely mostly on employees’ interpretation were introduced by the vast majority of safety recommendations. Also, statistically significant differences were detected across investigation authorities and time periods. This study demonstrated how the application of the suggested design and classification frameworks could reveal valuable information about the quality, scope and focus of recommendations. Especially the design criteria could function as a starting point towards the introduction of a common standard to be used at local, national and international levels.
Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced non-small-cell lung cancer: Southwest Oncology Group Trial S0003.

PURPOSE Tumor hypoxia confers chemotherapy resistance. Tirapazamine is a cytotoxin that selectively targets hypoxic cells. We conducted a phase III clinical trial to determine whether the addition of tirapazamine to paclitaxel and carboplatin offered a survival advantage when used in the treatment of patients with advanced non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS Of 396 patients registered, 367 eligible patients were randomly assigned to either arm 1 (n = 181), which consisted of treatment every 21 days with paclitaxel 225 mg/m2/3 h, carboplatin (area under the curve = 6), and tirapazamine 260 mg/m2 in cycle 1 (which was escalated, if tolerable, to 330 mg/m(2) in cycle 2), or arm 2 (n = 186), which consisted of paclitaxel and carboplatin as in arm 1 with no tirapazamine. RESULTS Patient characteristics were similar between the two arms. There were no statistically significant differences in response rates, progression-free survival, or overall survival. Patients on arm 1 had significantly (P < .05) more abdominal cramps, fatigue, transient hearing loss, febrile neutropenia, hypotension, myalgias, and skin rash and were removed from treatment more often as a result of toxicity than patients in arm 2 (26% v 13%, respectively; P = .003). More than 40% of patients did not have the tirapazamine dose escalated, primarily because of toxicity. The trial was closed early after an interim analysis demonstrated that the projected 37.5% improvement in survival (8 v 11 months median survival) in arm 1 was unachievable (P = .003). CONCLUSION The addition of tirapazamine to paclitaxel and carboplatin does not result in improved survival in advanced NSCLC compared with paclitaxel and carboplatin alone but substantially increases toxicity.
Depression and Parkinson's disease: a review.

OBJECTIVE The purpose of this review is to provide an update of the research regarding depression in Parkinson's disease and to synthesize the information into a neurobiological model relating the structural and biochemical changes in this disorder to the behavioral manifestations. METHOD The author used a computer-based search of the literature, augmented by extensive bibliography-guided article reviews, to find information on depression and Parkinson's disease. FINDINGS Depression occurs in approximately 40% of patients with Parkinson's disease; depression in Parkinson's disease is distinguished from other depressive disorders by greater anxiety and less self-punitive ideation. Lower CSF levels of 5-hydroxyindoleacetic acid, a past history of depression, and greater functional disability are associated with a greater risk of depression in Parkinson's disease. Female gender, early age at onset of Parkinson's disease, and greater left brain involvement may also be risk factors. Approximately half of depressed patients with Parkinson's disease meet criteria for major depressive episodes; half have dysthymia. Depression is more common in Parkinson's disease with prominent bradykinesia and gait instability than in tremor-dominant syndromes. Depressed patients with Parkinson's disease have greater frontal lobe dysfunction and greater involvement of dopaminergic and noradrenergic systems than nondepressed patients with the disease. Mood changes in Parkinson's disease respond to treatment with conventional tricyclic antidepressants or ECT. CONCLUSIONS Neurobiological investigations suggest that depression in Parkinson's disease may be mediated by dysfunction in mesocortical/prefrontal reward, motivational, and stress-response systems. Neuropsychological, metabolic, clinical, pharmacological, and anatomical studies support the involvement of frontal dopaminergic projections in patients with Parkinson's disease and depression.
A randomized clinical trial of peak flow versus symptom monitoring in older adults with asthma.

OBJECTIVE To determine whether peak flow monitoring has value above and beyond symptom monitoring when used as part of an asthma management plan. METHODS From a large managed-care organization, 296 adults, aged 50-92 yr, were recruited and randomly assigned in equal numbers to either use of symptoms or peak flow rate (twice daily or "as needed") for asthma monitoring, and monitored every 6 mo for 2 yr. Interventions were delivered in four 90-min small-group classes and included a personalized action plan and coaching in proper use of asthma inhalers. RESULTS We found no significant differences between peak flow rate and symptom monitoring, or between twice-daily and as-needed peak flow monitoring in the primary or secondary study outcomes: health care utilization (acute, nonacute, or total asthma visits), Asthma Quality-of-Life Questionnaire (AQLQ) scores, and lung function. AQLQ scores and prebronchodilator FEV1 increased significantly for both groups between baseline and 6 mo (AQLQ: mean, 0.4 units; 95% confidence interval, 0.3, 0.5; p < 0.0001; FEV1% predicted: mean, 4%). Inhaler technique improved substantially in both groups. CONCLUSIONS Peak flow monitoring has no advantage over symptom monitoring as an asthma management strategy for older adults with moderate-severe asthma when used in a comprehensive asthma management program. Improved outcomes in both groups suggest that understanding proper medication use, regular monitoring of asthma status, and understanding how to respond to changes are of primary importance.
Intra - Organizational Mobility: Movers, Incumbents, and Communication Networks

Despite the prevalence of intra-organizational mobility in organizations, the consequences associated with such activities remain undertheorized. In this paper, we investigate email communication amongst employees to examine how pre-move communication contacts (PMCs), contacts with the business unit receiving the movers, affect movers’ post-move performance. Using data on lateral moves within a large financial institution, we contend that movers suffer a performance disruption when they move, and moreover, movers with more pre-move contacts will exhibit a greater performance decrement than those with fewer or no pre-move contacts. The mechanism of social influence that could account for this pattern of results is examined. Our study provides insight into the structural factors that explain when and why movers do not benefit from intra-organizational mobility.
Cytokine Secretion from Human Monocytes Potentiated by P-Selectin-Mediated Cell Adhesion

Background/Aim: P-selectin is a carbohydrate-recognizing cell adhesion molecule expressed on activated platelets and endothelial cells. It plays a crucial role in the recruitment of leukocytes to inflammatory and hemorrhagic sites. Cell adhesion mediated by P-selectin induces leukocyte activation, such as the generation of reactive oxygen species and the expression of blood coagulation factors. We assessed how P-selectin-mediated cell adhesion affects cytokine secretion from monocytes. Methods: Human peripheral blood monocytes were cultured in a plate that had been coated with P-selectin purified from human platelets, and cytokines released in the culture supernatant from monocytes were determined by ELISA. Results: The secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-8, IL-12 and macrophage inflammatory protein-1β increased 3- to 10-fold in response to P-selectin compared with unstimulated monocytes. We next examined the effects of cytokine treatment of monocytes on their susceptibility to P-selectin. The secretion of TNF-α from monocytes in response to P-selectin was increased when monocytes were preincubated with granulocyte/macrophage colony-stimulating factor, monocyte chemotactic protein-1 or interferon-γ (IFN-γ); IFN-γ was the most effective in potentiating TNF-α secretion from monocytes. Conclusion: These results suggest that the interaction of monocytes with P-selectin plays an important role not only in their trafficking but also in the regulation of cytokine production by these cells.
Islam and Online Imagery on Malaysian Tourist Destination Websites

In December 1996, TIME magazine published an article titled "Finding God on the Web," which projected how the Internet would shape information seeking on faith and religion. A decade later, the Web has become a popular tool for gathering religious information as well as information and imagery related to religious travel. Yet there is little research on religious destination imagery online. Imagery—positive or negative, pictographic or narrative—influences the selection of tourism destinations. This study explored online Muslim images in Malaysia via interviews and content analyses of pictures and text on tourism destination websites' homepages. The results reveal minimal portrayal of Muslim images by Malaysian tourism destination organizations. This study adds to the small body of research, especially in Muslim countries, on online religious imagery and suggests avenues for tourism operators in Malaysia and elsewhere to improve their online image with both Muslim and non-Muslim travelers.
Aerobic and Lung Performance in Premature Children With and Without Chronic Lung Disease of Prematurity

Objective:This study intended to identify pulmonary and exercise-related effects of chronic lung disease of infancy (CLD) versus prematurity (PRE) without CLD in children 5 to 7 years old who were born prematurely (24-30 weeks of gestation) with very low and extremely low birthweight of 500 to 1500 g (VLBW, ELBW). Subjects:Seventeen CLD and 14 PRE were compared with 24 term controls (CON). The premature children had no overt manifestations of a neuromuscular disease. Methods:Pulmonary function at rest and following exercise, and aerobic exercise performance were measured. Results:Peak &OV0312;O2 and maximal aerobic power were not different among the groups, but O2 uptake at a given mechanical power was higher in the CLD than in PRE and in CON (P < 0.05). At rest, forced vital capacity was significantly lower in CLD than in PRE (P < 0.05) and CON (P < 0.0005), and FEV1 and FEF25-75 were lower in CLD than CON (P < 0.0005 and P < 0.005, respectively). Exercise-induced bronchoconstriction (EIB) was more prevalent among the 2 premature groups (P < 0.05). Conclusions:Our children 5 to 7 years old born at VLBW or ELBW, with or without CLD, have some degree of pulmonary dysfunction at rest and following exercise and a higher prevalence of EIB with no reduction in maximal aerobic exercise performance. The findings suggest that the pulmonary limitations are associated with low birthweight even in the absence of CLD. The higher O2 uptake at a given mechanical power in the CLD group may cause early fatigability during prolonged exercise, even when aerobic performance is normal.
The Effect of Good Corporate Governance and Earnings Management to Corporate Social Responsibility Disclosure

This study aims to investigate the effect of good corporate governance and earnings management towards disclosure of corporate social responsibility of 17 stated-owned companies listed on the Indonesia Stock Exchange in 2013 to 2015 by using the guidelines of Global Reporting Initiative (GRI). The data used in this study is secondary data and purposive sampling method is employed. The first independent variable of this study is the good corporate governance and it is measured by the composition of the board of commissioners, managerial ownership, state ownership, foreign ownership and audit committee. The second independent variable of this study is earnings management. The dependent variable is the level of disclosure of corporate social responsibility undertaken by the company and disclosed in the company's annual report. A multiple linear regression is employed to analyse the data of this study using SPSS version 17.0 software. The results indicate that managerial ownership, state ownership and audit committee have significant positive effects on the disclosure of corporate social responsibility in state-owned companies in Indonesia. The results also demonstrate that the composition of the board of commissioners, foreign ownership and earnings management do not have any effects on CSR disclosure.
Multinational study of pneumococcal serotypes causing acute otitis media in children

Background. Streptococcus pneumoniae is a major cause of acute otitis media (AOM) in young children. More than 90 immunologically distinct pneumococcal serotypes have been identified, but limited information is available regarding their relative importance in AOM. Methods. We analyzed nine existing datasets comprising pneumococcal isolates from middle ear fluid samples collected from 1994 through 2000 from 3232 children with AOM from Finland, France, Greece, Israel, several East European countries, the US and Argentina. We examined the distribution of pneumococcal serotypes in relation to several demographic and epidemiologic variables, including gender, age, antibiotic resistance and source of culture material. Results. The major serotypes identified included 19F and 23F, each comprising 13 to 25% of pneumococcal middle ear fluid isolates in most datasets; 14 and 6B, comprising 6 to 18%; whereas 6A, 19A and 9V each comprised 5 to 10%. Despite differences in location, study design and antibiotic susceptibility, each major serotype was prominent in most age groups of each dataset. Serotypes represented in the 7-valent pneumococcal conjugate vaccine (PCV-7, 4, 6B, 9V, 14, 18C, 19F, 23F) accounted for 60 to 70% of all pneumococcal isolates in the 6- to 59-month age range, but only 40 to 50% of isolates in children <6 or ≥60 months old. Serotype 3 and, in certain datasets, serotypes 1 and 5, were more important in the <6- and ≥60-month age groups. In each age group vaccine-related serotypes (mainly 6A and 19A) comprised an additional 10 to 15% of all pneumococcal isolates. Four serotypes (23F, 19F, 14 and 6B) accounted for 83% of all penicillin-resistant observations. Conclusions. This analysis of several geographically diverse datasets indicates that a limited number of serotypes, largely represented in PCV-7, accounted for the majority of episodes of pneumococcal AOM in children between 6 and 59 months of age. Certain serotypes appeared to be relatively more significant in children <6 months or >59 months of age.
The Mechanism of Accommodation and Presbyopia

Based on rigorous experimental, clinical, and mathematical analysis, the mechanism of accommodation and presbyopia is elucidated. During accommodation the anterior radial muscle segment of the ciliary muscle contracts toward the sclera, inducing an anatomically visible cavity, forward rotation of the ciliary processes, and increasing tension on the equatorial zonules. The equatorial zonules are the active component in determining the optical power changes of the lens, while the anterior and posterior zonules support the lens. Normal crystalline lens growth is the etiology of presbyopia.
Use of non‐anthracycline regimens in early stage breast cancer in Australia

Various factors have recently prompted a re‐evaluation of the role of non‐anthracycline regimens in early stage breast cancer (ESBC). Since 1990 anthracyclines have been a key component of chemotherapy regimens. However, there is increased understanding of the long‐term, irreversible toxicities associated with these therapies, including cardiac failure and secondary leukemia. The development of the taxanes in the 1990s led to new adjuvant chemotherapy regimens and trials of various combinations in an effort to further increase survival and reduce toxicity. Concerns about cardiac toxicity were reinforced with the emergence of trastuzumab for the treatment of HER2‐positive breast cancer. Trastuzumab alone causes cardiac toxicity and increases the risk of cardiac toxicity when combined with anthracyclines. These data, combined with recent results demonstrating the efficacy of non‐anthracycline regimens in various disease settings, have generated interest in utilizing these therapies in patients with both HER2‐positive and ‐negative tumors. This review outlines the evidence for the use of non‐anthracycline adjuvant regimens in ESBC, including cyclophosphamide, methotrexate and 5‐fluoruoracil, docetaxel, carboplatin and trastuzumab and docetaxel and cyclophosphamide, which have demonstrated equivalent efficacy and reduced toxicity compared to anthracycline‐based regimens in various trials. The review also examines evidence for the use of non‐anthracycline regimens in patients who previously had restricted access to these therapies due to their negative lymph node status. The wider availability of these regimens increases options when deciding upon adjuvant chemotherapy for patients with ESBC, especially in patients with a high risk of cardiac toxicity.
Discursive struggles between bidding and target companies: an analysis of press releases issued during hostile takeover bids

What are the types of interactions in the discursive struggles between the two parties involved in a hostile takeover bid? How is the legitimacy of the bid (de) constructed by both the bidding and target companies during their discursive struggles? This paper aims at addressing these research questions. Discursive struggles between the bidding and target companies are studied in a sample of 66 press releases related to seven hostile takeover bids approved by the French Market Regulator between December 2006 and December 2014. A study of the sequence followed by each party in issuing their press releases confirms the existence of strong interactions in all the hostile takeover bids studied. Using a manual content analysis methodology, we find that the disclosures made by the bidding and target companies consist of a series of attacks and defenses in which target companies are particularly offensive. We also give evidence that the two companies use legitimation, (de) legitimation and (re) legitimation arguments during discursive struggles, revealing the reciprocity of the communication between the two protagonists. We underline the symbolic or strategic dimensions of these legitimacy strategies in the view of the outcome of bids. Finally, we discuss the implications of our findings for regulators and make suggestions for future research. Based on the metaphor of ventriloquism, our research highlights the importance of considering disclosures as a dynamic and mutual influence process.