Miracle-dz/UniFAR-FTUs huggingface dataset:
Common Polymorphisms in ERCC2 (Xeroderma pigmentosum D) are not Associated with Breast Cancer Risk

A substantial proportion of the familial risk of breast cancer may be due to genetic variants, each contributing a small effect. The protein encoded by ERCC2 is a key enzyme involved in nucleotide excision repair, in which gene defects could lead to cancer prone syndromes such as Xeroderma pigmentosum D. We have examined the association between single nucleotide polymorphisms in the ERCC2 gene and the incidence of invasive breast cancer in three case-control series, with a maximum of 3,634 patients and of 3,340 controls. None of the three single nucleotide polymorphisms were significantly associated with the incidence of breast cancer.
South Asian Consensus Guidelines for the rational management of diabetes in human immunodeficiency virus/acquired immunodeficiency syndrome

As newer methods of management are made available, and accessible, survival rates with human immunodeficiency virus (HIV) are increasing. This means that chronic, metabolic complications of HIV are becoming more frequent in clinical practice, as acute morbidity is controlled. Management of HIV/acquired immunodeficiency syndrome (AIDS) is gradually expanding to include these chronic and metabolic complications of the disease, and the adverse effects associated with its treatments, including diabetes. Unfortunately, no guidelines are available to help the medical practitioners choose appropriate therapy for patients with these conditions. The aim of the South Asian Consensus Guidelines is to provide evidence-based recommendations to assist healthcare providers in the rational management of type 2 diabetes mellitus in patients with HIV. The development of these guidelines used systematic reviews of available evidence to form its key recommendations. These guidelines and associated review of literature represent a compilation of available knowledge regarding rational management of diabetes in HIV. Patients of diabetes with concomitant HIV infection are managed optimally with insulin therapy and judicious use of highly active antiretroviral therapy with suitable alternatives is also recommended. These guidelines should prove helpful to physicians, not only in South Asia, but also across the globe, while managing patients with coexistent HIV and diabetes.
Role of galectin-3 and CD44v6 expression in the differentiation of the follicular carcinoma and adenoma of the thyroid -

Objective: The role of the galectin-3 and CD44v6 expression in the differentiation of the thyroid follicular carcinoma and follicular adenoma were investigated in many preoperative cytologic samples and significant results were achieved. In this study, we investigated galectin-3 and CD44v6 as potential supportive markers of histopathologic diagnosis in the differentiation of follicular carcinoma and adenoma of thyroid in conventional tissue sections. Material and Method: A total of 60 thyroidectomy specimens from Kartal Dr. LA¼tfi KA½rdar Training and Research Hospital and Istanbul University Cerrahpasa Medical Faculty Pathology Department were investigated retrospectively. Twenty cases of the 60 thyroidectomy specimens were diagnosed as follicular carcinoma and 40 cases were diagnosed as follicular adenoma. Sections taken adjacent to the capsule of the nodule were stained immunohistochemically by HRP-AEC method for galectin-3 and CD44v6 antibody. Then sections were investigated under light microscope and labeled as no staining (-), focal weak staining (+), moderately intense staining (++), intense staining (+++). Results: Galectin-3 expression was significant in the differentiation of the follicular carcinoma and adenoma (p0.05). Conclusion: Galectin-3 was determined as a potential marker in the diagnosis of follicular carcinoma but CD44v6 expression was not a diagnostic value in the differentiation of follicular carcinoma and adenoma.
Profitability and Working Capital Management: The Jordanian Case

This paper aims to assess the effect of working capital management (WCM) on the performance. Utilizing unbalanced data for a sample of 49 Jordanian Industrial corporations listed at Amman Stock Exchange - 2005 to 2009. Using two alternative measures of profitability as proxy for the performance and five proxies for the Working Capital Management, estimation of twenty models panel data cross-sectional time series have been tested employing two regression models; the Fixed-Effects Model and the Ordinary Least Squares Model. The findings of our study found to be significantly consistent with the view of the traditional working capital theory. The results suggest that working capital management and performance are positively correlated. The regression results also concluded that the Jordanian industrial firms follow a conservative investing policy and less aggressive financing policy in the working capital, and a well-efficient managing of the working capital can add value to the shareholders wealth.
Implementing a Comprehensive Approach to the Study of Health Dynamics Using the Psychoneuroimmunology Paradigm

This article addresses psychoneuroimmunology (PNI) as an integrative paradigm for advancing both theoretical and empirical knowledge of physiological patterns that contribute to the dynamics of health. We depict relationships among relevant psychobehavioral and physiological components in a PNI-based framework. We then provide examples of how this framework guided 2 clinical trials designed to assess the effectiveness of selected nursing interventions to reduce stress and enhance coping, one in persons with human immunodeficiency viral disease and the other in persons with cancer. The examples address disease-specific measures for assessing the components of the PNI-based framework.
Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel gene. CF mutations like ΔF508 cause both a mistrafficking of the protein and a gating defect. Other mutations, like G551D, cause only a gating defect. Our aim was to find chemical compounds able to stimulate the activity of CFTR mutant proteins by screening a library containing approved drugs. Two thousand compounds were tested on Fischer rat thyroid cells coexpressing ΔF508-CFTR and a halide-sensitive yellow fluorescent protein (YFP) after correction of the trafficking defect by low-temperature incubation. The YFP-based screening allowed the identification of the antihypertensive 1,4-dihydropyridines (DHPs) nifedipine, nicardipine, nimodipine, isradipine, nitrendipine, felodipine, and niguldipine as compounds able to activate ΔF508-CFTR. This effect was not derived from the inhibition of voltage-dependent Ca2+ channels, the pharmacological target of antihypertensive DHPs. Indeed, methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-2(trifluoromethylphenyl)pyridine-5-carboxylate (BayK-8644), a DHP that is effective as an activator of such channels, also stimulated CFTR activity. DHPs were also effective on the G551D-CFTR mutant by inducing a 16- to 45-fold increase of the CFTR Cl- currents. DHP activity was confirmed in airway epithelial cells from patients with CF. DHPs may represent a novel class of therapeutic agents able to correct the defect caused by a set of CF mutations.
Acaricidal activity of compounds from Cinnamomum camphora (L.) Presl against the carmine spider mite, Tetranychus cinnabarinus.

BACKGROUND Tetranychus cinnabarinus (Boisduval) is one of the most important, highly polyphagous pests of a wide range of field and greenhouse crops throughout the world. The control of this mite is still based primarily on the use of synthetic chemical pesticides. In this study, we screened eight plant extracts from China and evaluated the natural compounds showing acaricidal properties from the plant extract, considering their potential use as an alternative to synthetic pesticides. RESULTS In bioassay screening assays, the Cinnamomum camphora (L.) Presl extract showed significantly greater acaricidal activity against T. cinnabarinus than the other seven plant extracts tested. Five compounds were identified from the C. camphora extract via repeated column chromatography and gas chromatography-mass spectrometry analysis. All the compounds presented acaricidal activity, with 2,4-di-tert-butylphenol and ethyl oleate exhibiting the greatest activity. At 7 days after treatment in a potted seedling experiment, the LC50 values of 2,4-di-tert-butylphenol and ethyl oleate were found to be 1850.94 and 2481.65 mg kg(-1) respectively. Microscopic observations showed that the mites displayed the symptomology of poisoning. CONCLUSION These results demonstrated that the C. camphora extract and its two active components show the potential to be developed as new natural acaricides for controlling carmine spider mites.
Nonlinear IHS: A Promising Method for Pan-Sharpening

The goal of pan-sharpening is to increase the spatial resolution of multispectral or hyperspectral images using a high-spatial-resolution panchromatic image. The intensity-hue-saturation (IHS) method is one of the most popular pan-sharpening methods. The pan-sharpening framework of the IHS method is simple, efficient, and of high spatial quality. In this letter, we propose a nonlinear IHS method. The main concern of this letter is how to accurately estimate the intensity component. The proposed method approximates the intensity component via local and global synthesis approaches. The WorldView-2 and DEIMOS-2 data are used to evaluate the performance of the proposed method. The experimental results demonstrate that the proposed nonlinear IHS method generates high-quality pan-sharpened multispectral bands in terms of quantitatively and perceptually.
IEC 61850 traffic analysis in electrical automation networks

The IEC 61850 protocol suite is emerging as a de-facto standard solution for the interoperability problem in automation networks. Intelligent Electronic Devices (IEDs) support this protocol and their recent deployment in substation automation systems (SAS) raises two questions. The first issue has to do with the traffic performance in an SAS and its scalability for fault management. It is vital to understand beforehand whether SAS traffic withstands extreme events, such as blackout situations, as is often claimed by their manufacturers. As our experience with these devices remains small, we look to simulating their behavior under varying SAS conditions. A second concern relates to the security of automation networks. There is a need to evaluate the reliability of SAS critical elements. Threats as diverse as terrorist and cyber attacks are feared [1]. Many countries are putting in place new regulations to combat such harmful actions. The IEC 61850 standard does not guaranty security, as this has been left as part of the scope of a different standard, namely, the IEC 62531 [6] [4]. The latter digitally signs the Generic Object Oriented Substation Event (GOOSE) messages carrying sampled measured values (SMV). Nonetheless, many devices on the market do not yet support IEC 62531. Additional security mechanisms include the use of Intrusion Detection Systems (IDS). These monitor and analyze network traffic in an attempt to detect anomalous and unwanted traffic. Some of these operate by capturing automation traffic and comparing it to known traffic profiles. A threshold may for example, be established to report unusual traffic patterns and to single them out as possible attack scenarios. These may then be more thoroughly investigated using specialized tools. This work provides a network level classification of GOOSE messages according to faults of an electricity energy system. More specifically, we will be looking at typical IEC 61850 response traffic that is generated as a result of a failure within an automation network. The measurements illustrate substation network traffic patterns for a problem such as a TriPhase or Phase-to-ground fault. The sampled data traffic is used for the modeling of traffic representing each of the power system faults. These models can then be used next to feed other specially devised simulators used for the analysis of the performance of an SAS. Furthermore, the established models may potentially play a considerable role in the identification of out-of-profile traffic that is likely to represent security threats. Finally, we expect the obtained models to help with the early diagnosis of this type of failures by simply observing their traffic signature. First, a brief introduction of the problem of traffic measurement is given. Section 2 introduces the reader to the terminology and describes the SAS scenario under evaluation. The third part of this document illustrates the measured results. A simple model, used to understand SAS traffic patterns is described. Finally, comments and pointers to future work are realized.
Novel UWB and Spread Spectrum System Using Time Compression and Overlap-Add Techniques

We present a UWB and spread spectrum communications method based on the idea of time compression where a sampled message signal is transmitted at a higher sampling rate. Robustness is achieved by dividing the signal into overlapping segments, transmitting each segment fast enough so that the segments no longer overlap, receiving these segments and reconstructing the message by overlap-adding the segments. A key feature of this scheme is that an exact sample rate match is not required to recover the signal. This method is implemented in a custom wideband software defined radio, with good results in the presence of interference and multipath. This method, referred to as time compression overlap-add (TC-OLA), represents a new concept and design approach and an advance in fundamental technology of the air interface physical layer that may be relevant to 5G wireless technologies.
Advanced Techniques for Modeling Terrorism Risk

The attack of September 11, 2001, demonstrated that terrorism is capable of inflicting damage and loss of life with a severity that is many multiples of the most extreme U.S. natural perils. This article addresses the need for a mathematical model for evaluating terrorism risk. The author compares and contrasts terrorism risk with other forms of catastrophe risk, and identifies human intelligence and intent as the distinguishing features. The author proceeds to propose that analytical techniques developed and applied within the discipline of wartime operations research (e.g., game theory, search theory), along with specialized statistical techniques, may be adopted to practically model the risk of terrorism. The article proceeds to demonstrate how even a highly simplified model can offer useful insights to the insurance industry with regard to this risk, although access to terrorism expertise is crucial.
The Signaling Role of IT Features in Influencing Trust and Participation in Online Communities

Operators of online communities (OCs) continuously try to create a trusting atmosphere and encourage user participation in their OC by implementing different information technology (IT) features that should signal a secure and high-quality environment for the exchange of content and personal information. However, without including users' perspective on which IT features actually affect trust and participation, uncertainty remains about whether OC operators are pulling the right levers. Although previous research has examined the effects of IT features on trust and participation in OCs, the field lacks a comprehensive perspective that compares users' trust perceptions and participation behavior induced by IT features with operators' efforts to provide these IT features in their OC. Drawing on signaling theory, we develop a technology-trust-participation research model that captures a dual perspective on how the provision of IT features, conceived of as IT-based signals or cues, affects users' trust perceptions and participation behavior. Employing a comprehensive quantitative research study, including an online-survey of 364 OC members and a content analysis of 80 general interest OCs, the authors show that five clusters of IT features (usability, transparency, quality-assured content, security, and privacy) vary in their impact on trust and participation, providing insights into their relative effectiveness. We found that although specific IT features are strong in building trust and participation, they are not sufficiently implemented in OCs. The results of this study advance our understanding about the different theoretical paths by which IT feature signals influence user participation and thus serve to mitigate uncertainty in online communities. By juxtaposing perceptual and objective data of users and OC operators, we are also able to identify various divergences between the perceived and actual significance of IT features' influence on trust and participation. Our findings also provide operators with guidelines that support them to effectively shape users' experiences in OCs.
Mesenchymal chondrosarcoma of the maxilla

Abstract We report, to our knowledge, the 10th recorded case of mesenchymal chondrosarcoma (MC) occurring in the maxilla. Our case is the youngest person reported with a tumour in this location. The prognosis for cure is poor with a high incidence of local recurrence as well as metastases. Treatment is based on radical surgery. Radiotherapy and chemotherapy have a adjuvant role but additional experience with this tumour is required to define the most efficacious treatment.
A Framework to Identify Service Quality Determinants of IT Enabled Scalable Ventures: A Study from Indian Context

The introduction of information and communication technology (ICT) has altered the service delivery around the world by making it more accessible and cost effective across e-service markets. In a country like India the problem of health is an enormous one where a majority of poor are outside the effective medical network. In order to address these problems many information and technology (IT) oriented new ventures have been established to eliminate the gap in health inequity by creating network of hospitals exclusively in non-urban areas. Despite of huge popularity of these services, identifying the quality of such services need careful attention. Exhaustive review of literature highlights that there exists little understanding for such a study in IT enabled Indian healthcare domain in context to new ventures/start-ups with an emergence of a gap. With the increasing rise of technology enabled new healthcare ventures there have been high rates of failure too due to lack of providing quality service, so it has become imperative to prioritize the contextual and sectoral specific settings of service quality issues as it is being felt increasingly that it is the quality that would ultimately decide the value of services. This paper thus attempts to prioritize the context specific service quality dimensions in IT enabled scalable healthcare ventures from Indian context with focus in non-urban regions by deploying technique for order preference by similarity to ideal solution (TOPSIS) methodology as multi-criteria decision making technique. Further this paper proposed a conceptual model as conjectural understanding of the antecedents to the start-ups and as a guide that can provides new entrepreneurial insights to the service managers who can better apportion their resource in order to build quality and scalability.
Can emergency physicians ‘rule in’ and ‘rule out’ acute myocardial infarction with clinical judgement?

Objective To determine the diagnostic accuracy of emergency physician gestalt in emergency department (ED) patients with suspected cardiac chest pain, both alone and in combination with initial troponin level and ECG findings. Methods We prospectively included patients presenting to the ED with suspected cardiac chest pain. Clinicians recorded their ‘gestalt’ at the time of presentation using a five-point Likert scale, blinded to outcome. Troponin T and high-sensitivity troponin T (hs-cTnT; both Roche Diagnostics Elecsys) levels were measured in admission blood samples. All patients underwent troponin testing at least 12 h after peak symptoms. The primary outcome was acute myocardial infarction (AMI). Results 458 patients were included in this study, 81 (17.7%) of whom had AMI. Clinician gestalt alone had an area under the receiver operating characteristic curve of 0.76 (95% CI 0.70 to 0.82) for AMI. Immediately discharging patients with normal initial troponin and ECG in whom the clinician felt the diagnosis was ‘probably not’ or ‘definitely not’ acute coronary syndrome (ACS) would have avoided admission for 23.1% (95% CI 19% to 28%) patients with 100% sensitivity (95% CI 95.6% to 100%). With hs-cTnT, 100% sensitivity could have been achieved even if only patients with ‘probable’ or ‘definite’ ACS were investigated further, which would have allowed 41.7% patients to be discharged immediately. Conclusions Gestalt alone cannot be used to ‘rule in’ or ‘rule out’ ACS. By combining clinician gestalt with the admission ECG and troponin level, we found 100% sensitivity without the need for serial troponin testing. These findings have the potential to reduce unnecessary hospital admissions for suspected ACS but must be prospectively validated before considering clinical implementation.
Yale‐Brown Obsessive Compulsive Scale: the dimensional structure revisited

The factor structure of the Yale‐Brown Obsessive‐Compulsive Scale (Y‐BOCS) has been examined in a number of prior investigations; however, findings have not consistently yielded a stable factor solution. The present study therefore tested the fit of each previously reported factor structure. One hundred thirty‐one adults with obsessive‐compulsive disorder (OCD) were administered the Y‐BOCS; a portion of these participants completed self‐report measures of depression and obsessive‐compulsive symptoms and were rated on a global impairment index. Consistent with the originally proposed structure, confirmatory factor analyses supported a factor structure comprised of obsession and compulsion factors. Reliability and convergent validity of these factors were generally satisfactory, although divergent validity was not entirely supported. Implications of these findings on scoring the Y‐BOCS are discussed. Depression and Anxiety 22:28–35, 2005. © 2005 Wiley‐Liss, Inc.