Miracle-dz/UniFAR-FTUs huggingface dataset:
LESION SIMULATING DISEASE 1 Interacts with Catalases to Regulate Hypersensitive Cell Death in Arabidopsis 1 [ C ] [ W ]

LESION SIMULATING DISEASE1 (LSD1) is an important negative regulator of programmed cell death (PCD) in Arabidopsis (Arabidopsis thaliana). The loss-of-function mutations in LSD1 cause runaway cell death triggered by reactive oxygen species. LSD1 encodes a novel zinc finger protein with unknown biochemical activities. Here, we report the identification of CATALASE3 (CAT3) as an LSD1-interacting protein by affinity purification and mass spectrometrybased proteomic analysis. The Arabidopsis genome contains three homologous catalase genes (CAT1, CAT2, and CAT3). Yeast two-hybrid and coimmunoprecipitation analyses demonstrated that LSD1 interacted with all three catalases both in vitro and in vivo, and the interaction required the zinc fingers of LSD1. We found that the catalase enzymatic activity was reduced in the lsd1 mutant, indicating that the catalase enzyme activity was partially dependent on LSD1. Consistently, the lsd1 mutant was more sensitive to the catalase inhibitor 3-amino-1,2,4-triazole than the wild type, suggesting that the interaction between LSD1 and catalases is involved in the regulation of the reactive oxygen species generated in the peroxisome. Genetic studies revealed that LSD1 interacted with CATALASE genes to regulate light-dependent runaway cell death and hypersensitive-type cell death. Moreover, the accumulation of salicylic acid was required for PCD regulated by the interaction between LSD1 and catalases. These results suggest that the LSD1-catalase interaction plays an important role in regulating PCD in Arabidopsis.
The Influence of International Tourism Receipts on Economic Development: Evidence from China’s 31 Major Regions

This study applies a bootstrap panel Granger causality test to examine the causal relationship between international tourism receipts and economic growth in China’s 31 major regions for the period from 1995 to 2015, accounting for both dependency and heterogeneity across regions. The empirical results of this study support evidence for the growth hypothesis in the regions, such as Anhui, Henan, Jiangxi, Jilin, Fujian, Jiangsu, Shandong, Tianjin, Chognqing, Inner Mongolia, Qinghai, Tibet, and Yunnan. A reverse relationship supports evidence on the conservation hypothesis for the regions, such as Hubei and Hunan. A reciprocal causal relationship was found in Hebei and Shannxi, while the result of a neutrality hypothesis supported 14 of these 31 major regions (i.e., Heilongjiang, Shanxi, Beijing, Guangdong, Hainan, Liaoning, Shanghai, Zhejiang, Gansu, Guangxi, Guizhou, Ningxia, Sichuan, and Xinjiang). The empirical findings of this work provide important policy implications for China’s 31 major regions.
Physical and sedentary activity in adolescents with cerebral palsy

Participation in regular physical activity (PA) provides health, psychological, and physiological benefits for people with and without a physical disability. This study investigated the physical and sedentary activity patterns of adolescents with cerebral palsy (CP). A cross‐sectional, descriptive, postal survey was used, consisting of the Physical Activity Questionnaire for Adolescents (PAQ‐A), self‐reported level of gross motor function (based on the Gross Motor Function Classification System [GMFCS]), and specific questions regarding weekly sedentary activities. Following piloting to determine test‐retest reliability (intraclass correlation [ICC] for PA=0.90; total weekly sedentary time=0.84) and concurrent validity (survey PA score vs pedometry, Pearson's r=0.24; survey PA score vs accelerometry, r=‐0.21; survey weekly sedentary time vs logbook, r=0.38), the survey was mailed to all adolescents with CP in South Australia registered with Novita Children's Services (n=219). One hundred and twelve valid surveys were returned (76 males, 36 females; age range 11‐17y, mean age 13y 11mo [SD 23mo]; GMFCS Level I, n=42; Level II, n=27; Level III, n=10; Level IV, n=17; Level V, n=15; level not reported, n=1). Results were compared with recent normative age‐ and sex‐matched data sets. Key findings were that PA level of adolescents with CP was related to level of gross motor function and inversely related to age, and that adolescents with CP were less physically active than their peers without disability. Comparisons with normative data sets suggested that adolescents with CP tend to participate in less structured and lower intensity PA compared with non‐disabled adolescents, though sedentary activity patterns (TV and computer use) of adolescents with and without CP were similar.
Strategic CSR for airlines: does materiality matter?

Purpose Considering the increasing significance of corporate social responsibility (CSR) in the corporate world and the mixed findings of the financial implication of CSR investment in the financial economics literature, the purpose of this study is to examine the relationship between (im)material CSR investment and firm performance and the moderating role of airline type and economic conditions based on the stakeholder theory and institutional pressure argument. Design/methodology/approach This study uses a two-way random-effects model by firm and year along with using clustering coefficient estimation by firm to control for the possibility of inflated standard errors because of autocorrelation across years within a given firm. Findings This study finds that both material and immaterial CSR initiatives do not directly influence firm performance, but airline type and economic conditions do moderate the relationship. In specific, the study found that airlines’ investments in material CSR initiatives show an indifferent effect on firm performance between low-cost and full-service carriers and also between non-recessionary and recessionary periods. On the other hand, investments in immaterial CSR initiatives present different impacts on firm performance between low-cost and full-service carriers and between non-recessionary and recessionary periods. In details, the effect is more negative for low-cost carriers and recessionary periods than full-service carriers and non-recessionary periods. Originality/value This is the first empirical investigation of materiality for the airline industry in relation to firm performance using the industry-specific Materiality Map developed by the Sustainability Accounting Standards Board. Further, this study incorporates two additional moderators (airline type and economic conditions) to enhance the understanding of the proposed relationships between (im)material CSR and firm performance.
MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

The MARCH family of proteins are membrane-associated E3 ubiquitin ligases that down-regulate surface membrane proteins. Expression of MARCH8 in cells causes the ubiquitination and down-regulation of surface CD98 and CD44—cargo proteins that enter cells by clathrin-independent endocytosis and are usually routed to recycling, not degradation.
[Coraco-humeral space and rotator cuff tears].

PURPOSE OF THE STUDY The anterior or subcoracoïd impingement is often mentioned but remains unprecise as far as clinical, radiological or even anatomical lesion are concerned. The purpose of our work was to study the different factors influencing the subcoracoïd space in case of cuff tear. METHODS Our study was based on 206 shoulders operated for full-thickness rotator cuff tear. The SubCoracoïd Space (SPS), measured in millimeters on pre-operative arthro-CT-scan, was defined by the shortest distance between the coracoïd process and the humeral head. Muscular statement of the rotator cuff componants was graded according to Goutallier's and Bernageau's classification. According to literature data, we chose "6 mm" value as an inferior limit for normality. Shoulders were dispatched into three groups: group 1 was composed of supraspinatus +/- infraspinatus tears (59 cases), group 2 was composed of isolated lesions of the subscapularis (57 cases) and group 3 was composed of large cuff tears (supraspinatus +/- infraspinatus) involving also the subscapularis (90 cases). RESULTS There was a statistically significant relationship between SCS narrowing, duration of symptoms and the non-traumatic onset. When there was no subscapularis lesion (group 1) the mean SCS was 9 +/- 2 mm, in 3 cases the SCS was inferior to 6 mm. In group 2 (isolated lesion of the subscapularis), the results were similar with 9 mm as an average and 3.5 p. 100 SCS inferior to 6 mm. On the contrary, in group 3 we found the major percentage of SCS inferior to 6 mm (27 p. 100) with an average of 7.7 +/- 3.5 mm. The long head of the biceps had no influence on the SCS. There was a strong statistically significant relationship between SCS size and fatty degeneration of the subscapularis muscle (p < 10-4) and infraspinatus muscle (p = 0.0004). Eventually, there was a statistically significant correlation between the subcoracoïd space and the sub acromial space. DISCUSSION Measurements of the SCS in isolated lesions of the subscapularis show that the coracoïd process is not the mechanical factor responsible for tendon rupture. SCS narrowing is the consequence of a large cuff tear involving both the subscapularis and the infraspinatus tendon. Subscapularis tear is a necessary but not a sufficient condition by itself for SBS narrowing. Complete tear of the infraspinatus tendon and above all the muscular degeneration of the infraspinatus muscle is the other necessary condition for SCS narrowing. The horizontal control of the humeral head depends on subscapularis-infraspinatus muscular balance control. According to Patte's hypothesis SCS narrowing corresponds to an horizontal anterior translation of the humeral head due to fatty degeneration of subscapularis and infraspinatus muscle.
Design of an Ironless Double-Rotor Radial Flux Permanent Magnet machine

This paper presents initial work and prototyping of an Ironless Double-Rotor Radial Flux Permanent Magnet (IDRFPM) machine. The design stems from high-efficiency generators intended for wind power but will be used in motor operation to propel a small vehicle for the Shell Eco Marathon where efficiency is of paramount importance. The design intends to augment performance by increasing torque density, replacing heavy steel yoke components with non-magnetic composites and tangentially magnetized PM's to form a quasi-Halbach arrangement. This text will explain basic performance characteristics of the machine and review the design methodology and development of the topology. A comparison is made of the torque densities of the new topology and its predecessor. The analysis concludes that, while initial results indicate favourable torque density, testing of a prototype and development of a thermal model will be necessary to directly compare the IDRFPM machine with competitors.
Blood volume expansion and cardiorespiratory function: effects of training modality.

PURPOSE To evaluate the effects of different modalities of aerobic (i.e., interval (INT) and continuous (CONT)) training on cardiorespiratory function and the importance of training-induced blood volume (BV) expansion on aerobic power and LV function. We hypothesized that if modality-mediated differences in cardiorespiratory function exist after INT and CONT, they would be related directly to differences in training-induced hypervolemia. METHODS We examined the effects of 12 wk of CONT and INT on BV, volume-regulatory hormones (angiotensin II, aldosterone, atrial natriuretic peptide), and cardiorespiratory function in 20 untrained males (mean age 30 +/- 4 (SD)). Participants were stratified (mass and VO2max) and randomly assigned to control, CONT, or INT. RESULTS There were no significant changes in cardiorespiratory function or BV in the control group. Twelve weeks of continuous and interval training, respectively, resulted in significant changes in VO2max (23 +/- 18 vs 21 +/- 10%), peak stroke volume (20 +/- 18 vs 11 +/- 18%), and BV (12 +/- 9 vs 10 +/- 6%). Changes in VO2max were directly related to changes in BV (r = 0.47). Angiotensin II significantly increased after 1 wk of CONT and INT and thereafter returned to baseline values. There was no significant difference between the CONT and INT groups with regard to changes in vascular volumes, volume-regulatory hormones, and/or cardiorespiratory function. CONCLUSIONS These data indicate that: 1) 12 wk of CONT and INT result in similar improvements in VO2max, and LV function and 2) training-induced hypervolemia accounts for approximately 47% of the changes in VO2max after CONT and INT.
Interleukin 7 (IL-7) selectively promotes mouse and human IL-17–producing γδ cells

IL-17–producing CD27− γδ cells (γδ27− cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-γ–producing γδ27+ cells are poorly elucidated. Moreover, although human IL-17–producing γδ cells are commonly implicated in inflammation, such cells themselves have proved difficult to isolate and characterize. Here, murine γδ27− T cells and thymocytes are shown to be rapidly and substantially expanded by IL-7 in vitro and in vivo. This selectivity owes in substantial part to the capacity of IL-7 to activate STAT3 in such cells. Additionally, IL-7 promotes strong responses of IL-17–producing γδ cells to TCR agonists, thus reemphasizing the cells’ adaptive and innate potentials. Moreover, human IL-17–producing γδ cells are also substantially expanded by IL-7 plus TCR agonists. Hence, IL-7 has a conserved potential to preferentially regulate IL-17–producing γδ cells, with both biological and clinical implications.
Hyperhomocysteinemia, coronary heart disease, and diabetes mellitus as predicted by various definitions for metabolic syndrome in a hypertensive Saudi population.

OBJECTIVE From the emergence of different definitions of metabolic syndrome (MS) we aim to determine the prevalence of such a condition among hypertensive Saudi population and to identify which definition can best assess the risk of hyperhomocysteinemia, coronary heart disease (CHD), and diabetes mellitus. METHODS In this cross-sectional study, we studied 581 hypertensive Saudis, aged 21-70, at the King Abdul-Aziz University Hospital, from June 2005 to December 2005 Each participant completed the questionnaire and underwent a complete physical examination. Metabolic parameters were measured using routine laboratory procedures and homocysteine using HPLC by the electrochemical detection method. RESULTS According to the International Diabetes Federation (IDF) definition we diagnosed 222 males and 256 females. There is an increased risk for hyperhomocystenemia using the Adult Treatment Panel III (ATPIII) guidelines (odds ratio [OR] 3.30, 95% confidence interval [CI] 0.87-12.56; p=0.08) compared to IDF (OR 0.59, CI 0.17-2.10; p=0.41) and WHO (OR 0.45, CI 0.16-1.25; p=0.12); increased risk for probable CHD in patients with MS by WHO (OR 2.17, CI 1.11-4.25; p=0.02) compared to ATPIII (OR 2.14, CI 1.05-4.35; p=0.035) and IDF (OR 0.81, CI 0.37-1.78; p=0.6); risk of DM is highest with IDF (OR 13.07, CI 1.66-102.94; p=0.015). CONCLUSION There is a high prevalence of MS among hypertensive Saudis regardless of definition used; it is most prevalent using the IDF definition as well as the risk for diabetes Patients diagnosed with ATPIII guidelines have greater risk of hyperhomocysteinemia. We recommend the WHO definition for Arabs since it predicts increased risk for CHD.
Regional Wages and the North-South Disparity in Italy after the Unification

Information on wages has never been exploited in the longlasting debate on North-South disparities in Italy in the aftermath of the national Unification. The present article is based on a wide array of data on provincial wages in the building sector over the period 1862-1878. Nominal wages in the Centre-North and the South, including the Islands, were similar, because of the high wage levels in Sardinia and Sicily. In the peninsular South, nominal wages were about 10-15 percentage points lower than in the Centre-North. Yet, whenever the difference in prices is taken into account, any disparity between Centre-North and Mezzogiorno fades away.
Credit Booms-Is China Different?

Strong Chinese output growth after the Global Financial Crisis was supported by booming credit. This credit boom carries risks. International experience suggests that Chinaâs credit growth is on a dangerous trajectory, with increasing risks of a disruptive adjustment and/or a marked growth slowdown. Several China-specific factorsâhigh savings, current account surplus, small external debt, and various policy buffersâcan help mitigate near-term risks of a disruptive adjustment and buy time to address risks. But, if the risks are left unaddressed, these mitigating factors will likely not eliminate the eventual adjustment, but make the boom larger and last longer. Hence, decisive policy action is needed to deflate the credit boom safely.
The demand for cash in France: review of evidence

Despite the well-known difficulties to measure national euro circulations within the euro area, several methods have been used to estimate the national demand for euro banknotes in France, such as key-based calculations (ECB capital), approaches using average return time of banknotes or extrapolated data from legacy currencies historical trends, methods relying on the replacement indicators of the first euro banknote series. This paper proposes an update of these approaches and complements them with two additional methods. First, exportations of banknotes data enable to infer the French national circulation from the difference between banknotes issued by the Banque de France and the banknotes it shipped outside the euro area, directly or via the French wholesale bank. Second, a “bottom-up” approach can be built-up, where the cash holdings of the different institutional sectors (MFIs, households, non-financial corporations) are summed up in order to estimate the use of cash for transactional purpose. Bearing in mind that those various approaches do not always separate the hoarding from the transactional purposes nor take into account banknotes migrations flows across countries, the analysis of the similarities and differences between those several methods sheds light on the French national demand for cash by giving hints on both the low and the top ends of the range.
Prevention and management of transplant-associated diabetes

Introduction: New-onset diabetes after transplantation (NODAT) is considered to be a major cause of cardiovascular disease and death among patients with a functioning allograft. A major challenge is to reduce the incidence of NODAT and to treat it optimally once it has occurred. Areas covered: This review presents current data on how to prevent NODAT in patients at risk, with a focus on modifications in the immunosuppressive regimen. Current suggestions for detection and treatment of NODAT are also presented. Expert opinion: Prevention of NODAT is possible by assessing the patient's glycemic risk prior to transplantation and tailoring the treatment (e.g., choice and dosage of immunosuppressive agents) after transplantation. An oral glucose tolerance test is still the gold standard to detect NODAT in patients at risk (prediabetes) but algorithms can be used to select those who should be tested. The treatment of NODAT involves a broad approach on risk factors for cardiovascular events and graft loss. Future studies on the use of oral hypoglycemic agents in NODAT are still needed.
Hyperpolarization of resting membrane potential causes retraction of spontaneous transients during mouse embryonic circuit development

A wave of electrical activity occurs in the developing brain for a certain period of time before sensory, motor and cognitive functions mature. This electrical activity, or spontaneous activity, originates, spreads, then later retracts and disappears in specific areas of the brain at specific time points, but how it retracts is unknown. We report that retraction in the mouse embryonic hindbrain is caused by a reduced excitability in the network of cells. This process can be reversed by bath application of high K+ solution, which increases excitability. This reduced excitability is probably caused by increased number of K+ pores that are always open in individual cells. These results help us understand how the spread of spontaneous activity is regulated and ultimately help us better understand the role of electrical activity during development of the fetal brain.
Rethinking Effective Public Engagement in Sustainable Forest Governance

Abstract Addressing environmental problems through conventional expert and scientific approaches alone is largely ineffective. Therefore, Canadian forest management has evolved to include governance processes such as public advisory committees. Public participation is mandated by federal and provincial policy and is a key part of forest certification processes. In this context, self-reports of committee effectiveness and satisfaction are common indicators of meaningful governance. Yet we often know very little about what people mean when they indicate that a process is effective. Using a 2016 national survey of PAC members across Canada (n = 345), empirical findings confirm that personal perceptions of fairness, inclusion, and (to a lesser extent) social learning determines individual judgments of committee effectiveness and satisfaction. Policy recommendations include a sharper focus on social learning as a key governance outcome.
Comparative proteomic analysis of human mesenchymal and embryonic stem cells: Towards the definition of a mesenchymal stem cell proteomic signature

Mesenchymal stem cells (MSC) are adult multipotential progenitors which have a high potential in regenerative medicine. They can be isolated from different tissues throughout the body and their homogeneity in terms of phenotype and differentiation capacities is a real concern. To address this issue, we conducted a 2‐DE gel analysis of mesenchymal stem cells isolated from bone marrow (BM), adipose tissue, synovial membrane and umbilical vein wall. We confirmed that BM and adipose tissue derived cells were very similar, which argue for their interchangeable use for cell therapy. We also compared human mesenchymal to embryonic stem cells and showed that umbilical vein wall stem cells, a neo‐natal cell type, were closer to BM cells than to embryonic stem cells. Based on these proteomic data, we could propose a panel of proteins which were the basis for the definition of a mesenchymal stem cell proteomic signature.
Cohort Change in Political Gender Gaps in Europe and Canada: The Role of Modernization

This article finds firmer evidence than has previously been presented that men are more left-wing than women in older birth cohorts, while women are more left-wing than men in younger cohorts. Analysis of the European Values Study/World Values Survey provides the first systematic test of how processes of modernization and social change have led to this phenomenon. In older cohorts, women are more right-wing primarily because of their greater religiosity and the high salience of religiosity for left-right self-placement and vote choice in older cohorts. In younger, more secular, cohorts, women’s greater support for economic equality and state intervention and, to a lesser extent, for liberal values makes them more left-wing than men. Because the gender gap varies in this way between cohorts, research focusing on the aggregate-level gap between all men and all women underestimates gender differences in left-right self-placement and vote choice.