Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence And Severity of Periodontal Disease in Type 2 Diabetes Mellitus ( Non – Insulin Dependent Diabetes Mellitus ) Patients In Srinagar City

Background: Periodontal disease has been labeled as the sixth complication of the diabetes. Abnormal collagen metabolism, abnormal polymorphonuclear cell function and altered sulcular microbial flora progresses periodontitis among diabetic patients. Aim: To find out the prevalence and severity of periodontal disease among Non-insulin dependent Diabetes Mellitus Patients in srinagar city jammu and kashmir India. Materials and Methods: 50 patients with type 2 diabetics (mean age: 49.3 ± 8.97) and 50 patients with nondiabetics (mean age: 47.6 ± 8.85) were examined. Plaque component of ramfjord’s Periodontal Disease Index (PBI) (Schick and Ash Modification 1961), Papillary Bleeding Index (PBI) (Muhlemann H.R 1977), Periodontal Disease Index (PDI) (Sigurd P. Ramfjord 1967), Relative Attachment level (RAL) were recorded. Data was analyzed using SPSS version 15. P ≤ 0.05 and ≤0.01 was considered as statistically significant and highly significant respectively Results: Diabetics had significantly higher mean PBI (p<0.01), PDI (p<0.05) than non-diabetics. The mean P1 (p >0.05) and RAL (p> 0.05) although were higher in diabetics than non-diabetics but not significantly different between the two groups. Conclusion: Type‐ II diabetic patients have a higher prevalence of periodontal disease than non diabetic individuals. More emphasis is to be put on the co-managemnt of oral and overall health in patients with diabetes by dental and general practitioners.
Multiple enhancer domains in the 3' terminus of the Prague strain of Rous sarcoma virus.

The 3' terminal region of the Prague strain of Rous sarcoma virus (PrRSV) contains at least three distinct domains that comprise two functional enhancer elements. Two of these domains (designated B and C) are found in the U3 region of the 3' long terminal repeat (LTR) while the third (designated A) is located in the sequences immediately preceding the LTR termed XSR sequences. Combinations of adjacent domains [e.g., (A + B or B + C)] are capable of activating the expression of the SV40 early promoter (21 bp repeats and TATA box) coupled to coding sequences from the prokaryotic gene chloramphenicol acetyltransferase (CAT) while a single domain is inactive. Furthermore, duplication or triplication of the central domain B restores activity. The related, Schmidt-Ruppin, strain of RSV, contains an almost identical 3' LTR element, but differs in the enhancer sequences immediately preceding the 3' LTR. A model is presented in which the sequence differences may contribute to the difference in disease spectrum of transformation defective (td) variants of these viruses.
Telomere length associated with the risks of high-risk and ischemic stroke in southern Chinese Han population

Some previous studies suggested telomere length was associated with the risk of ischemic stroke (IS). The aim of this study was to further confirm the association between relative telomere length (RTL) and risk of IS and to especially explore its correlation with the risk of high-risk stroke population in southern Chinese Han. RTL was determined by using real-time quantitative polymerase chain reaction from 400 ischemic stroke patients, 409 high-risk stroke populations and 399 healthy controls. The correlations between the controls and the risk of high-risk and ischemic stroke were evaluated by using an unconditional logistic regression. IS patients have shown longer RTL than controls (median1.52vs1.11, p60 years) and gender suggested that the first and second tertile of RTL were correlated with the risk of IS in each group when the second tertile was used as a reference. However, the increased risk for high-risk stroke populations were only presented in the first tertile of RTL in the age≤60 years and female groups. the RTL was associated with an increased risk of ischemic stroke, while it elevated the risk of high-risk stroke in some specific subpopulations.
Serum Amino Acids, Liver Status, and Antiepileptic Drug Therapy in Epilepsy

Summary: Serum amino acid (AA) profiles are altered in epilepsy. It is not clear whether this is due to the disease process itself or to other variables such as seizure type, seizure frequency, duration of illness, medication, or altered liver function. We investigated serum AA profiles and liver enzymes in 73 epileptic patients and 90 healthy subjects and evaluated the data by analysis of variance to discriminate between age, sex, seizure type, duration of illness, seizure frequency, antiepileptic drug (AED) and increased serum liver enzyme levels, and their putative interaction with the serum A A profile. There was no correlation between the changes in the AA profile and age, duration of illness, seizure frequency, and seizure type. Seventy‐two percent of the AED‐treated patients and 33% of the unmedicated patients showed an increase in one or several serum liver enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), and/or γ‐glutamyl transferase (γ‐GT)]; particularly γg‐GT. We observed a significant increase in serum concentrations of glutamine and glycine and decreased levels of taurine, threonine, serine, valine, methionine, isoleucine, leucine, phenylalanine, histidine, tryptophan, and arginine in AED‐treated patients but not in unmedicated patients. These results show that the changes in the serum AA profiles of epileptic patients treated with AEDs occur in patients with alteration of serum liver enzymes; whether this implies a causal relation is still uncertain.
Recent achievements in external radiation dosimetry

Some of the more relevant recent achievements and developments in the field of external radiation dosimetry are reviewed in this presentation. Among them, topics related to personal dosimetry, as the relative role of active and passive methods and the features of some recently proposed new methods. Electronic personal dosemeters and Optically Stimulated Luminescence, OSL, have already accredited their adequacy for practical work, their features and performance are compared with more conventional methods as TLD. The special situation of personal dosimetry for the protection of the staff in complex interventional radiology procedures, is also commented. Underestimations as well as overestimations of the effective dose are to be avoided without a clear solution for the moment respect to the number and position of the personal dosimeters. Some recent recently results published related to single and double dosimetry are discussed. The situation of neutron dosimetry, both area and personal, is reviewed following the recently published results obtained by a European research consortium (Evidos). While the situation of area dosimetry is more or less comfortable, personal methods still present drawbacks and limitations particularly with respect to the energy dependence of response. The impact of computational methods for practically every area of dosimetry is another topic included in this Key Note that finishes with some reference to the new 2007 ICRP recommendations regarding the dosimetry system.
MULTIOBJECTIVE SYNTHESIS OF LOW-POWER REAL-TIME DISTRIBUTED EMBEDDED SYSTEMS

This dissertation presents methods for automating the synthesis of embedded systems, i.e., special-purpose computers. In addition, it describes a method for analyzing the manner in which real-time operating system use influences embedded system power consumption. After introducing the embedded system synthesis problem and summarizing previous work in the field, we present four evolutionary algorithms that simultaneously optimize the different costs of embedded systems, e.g., price, power consumption, response time, and area, while ensuring that hard real-time constraints are met. These algorithms generate multiple solutions that present tradeoffs between different architectural costs. Each algorithm targets a different embedded system domain. The first algorithm synthesizes distributed embedded systems. The second synthesizes systems-on-chip composed of intellectual property cores that may come from different vendors. It does clock selection, floorplanning block placement, and bus topology generation. The third synthesizes distributed client-server systems in which the bandwidth of client-server communication is tightly constrained, e.g., wireless embedded systems. It incorporates a novel scheduling method tailored to embedded systems with multiple clients for each server. The fourth synthesizes embedded systems that may contain reconfigurable processors. In addition, we present a method of analyzing the effects of real-time operating system usage on the overall performance and power consumption of embedded systems.
3 case reports of edema associated with quetiapine.

BACKGROUND Edema associated with quetiapine has been described in only one case report to date and represents a potentially serious adverse reaction. METHODS We present a case series of 3 patients who developed bilateral leg edema following initiation of quetiapine. RESULTS One of these patients had a recurrence of edema with subsequent rechallenge. Another patient developed quetiapine-induced edema following a prior episode of olanzapine-induced edema. All 3 cases present a compelling temporal relationship between the drug challenge and the adverse event. CONCLUSION Prompt recognition and intervention with discontinuation of the offending agent is important for this potentially serious, seemingly idiosyncratic vascular complication.
Breast reconstruction with alloplastic implants

This article reviews immediate and delayed breast reconstruction with prosthetic implants, and the effect of irradiation therapy. Despite widespread use of breast conserving surgery for early breast cancer, many breast cancer patients still undergo mastectomy. Some of these patients choose breast reconstruction. Over the last 30 years, techniques for breast reconstruction have evolved significantly with new alternative techniques and improved surgical devises. Immediate or delayed breast reconstruction with silicone prosthesis can be an excellent option. Implant reconstruction may be single or two stage procedures. Traditionally, small breasts with minimal ptosis are suited for single‐stage reconstruction. Large breasts or inadequate skin require expanders followed by implants. Minimal excision mastectomy and biological spacers are allowing larger breast single stage reconstruction and improved aesthetics for two stage procedures. With recent studies suggesting survival advantage of post‐mastectomy irradiation, many candidates for breast reconstruction are receiving radiotherapy, which complicates healing after breast reconstruction. J. Surg. Oncol. 2006;94:471–478. © 2006 Wiley‐Liss, Inc.
Parental Prescription Opioid Abuse and the Impact on Children

Objective: The purpose of this study was to identify which characteristics of opioid-abusing parents were associated with greater global impairment of their children. Methods: Data regarding participant demographics, drug use, and child demographics were collected from 14 patients in a chemical dependency unit who had at least one child between the ages of 4 and 17, inclusive. Child global impairment was measured by the parents’ report using the Brief Impairment Scale (BIS). Regression analyses were conducted to assess which parental characteristics were associated with child BIS scores. Results: The mean age of the 14 participants was approximately 40 years, 9 (64.3%) were women, and 12 (85.7%) were white. At the time of hospitalization, 12 (85.7%) had had prior substance abuse treatment, 9 (64.3%) had received prescription opioids through non-medical sources, and 9 (64.3%) had a criminal history. The mean BIS score of 24 children was 15.5, which is associated with moderate global impairment of function. Greater child BIS scores were associated with a number of parental characteristics, such as obtaining any prescription opioids through non-medical sources, having a greater number of arrests, previously using drugs intravenously, and having a greater number of prior substance abuse treatment episodes. Conclusions: By assessing these parental characteristics, clinicians may be able to assess children who are at risk for impairment and, in turn, may be in need of mental health services. Due to limitations of this study, further evaluation is needed.
Persistent genital tract HIV-1 RNA shedding after change in treatment regimens in antiretroviral-experienced women with detectable plasma viral load.

OBJECTIVE To longitudinally assess the association between plasma viral load (PVL) and genital tract human immunodeficiency virus (GT HIV) RNA among HIV-1 infected women changing highly active antiretroviral therapy (HAART) because of detectable PVL on current treatment. METHODS Women were eligible for the study if they had detectable PVL (defined as two consecutive samples with PVL>1000 copies/mL) and intended to change their current HAART regimen at the time of enrollment. Paired plasma and GT HIV-1 RNA were measured prospectively over 3 years. Longitudinal analyses examined rates of GT HIV-1 RNA shedding and the association with PVL. RESULTS Sixteen women were followed for a median of 11 visits contributing a total of 205 study visits. At study enrollment, all had detectable PVL and 69% had detectable GT HIV-1 RNA. Half of the women changed to a new HAART regimen with ≥3 active antiretroviral drugs. The probability of having detectable PVL ≥30 days after changing HAART was 0.56 (95% CI: 0.37 to 0.74). Fourteen women (88%) had detectable PVL on a follow-up visit ≥30 or 60 days after changing HAART; and 12 women (75%) had detectable GT HIV-1 RNA on a follow-up visit ≥30 or 60 days after changing HAART. When PVL was undetectable, GT shedding occurred at 11% of visits, and when PVL was detectable, GT shedding occurred at 47% of visits. CONCLUSIONS Some treatment-experienced HIV-infected women continue to have detectable virus in both the plasma and GT following a change in HAART, highlighting the difficulty of viral suppression in this patient population.
Activity of the turbidite levees of the Celtic – Armorican margin ( Bay of Biscay ) during the last 30 , 000 years : Imprints of the last European deglaciation and Heinrich events

High-resolution sedimentological and micropaleontological studies of several deep-sea cores retrieved from the levees of the Celtic and Armorican turbidite systems (Bay of Biscay — North Atlantic Ocean) allow the detection of the major oscillations of the British–Irish Ice Sheet (BIIS) and ‘Fleuve Manche’ palaeoriver discharges over the last 30,000 years, which were mainly triggered by climate changes. Between 30 and 20 cal ka, the turbiditic activity on the Celtic–Armorican margin was weak, contrasting with previous stratigraphic models which predicted a substantial increase of sediment supply during low sea-level stands. This low turbidite deposit frequency was most likely the result of a weak activity of the ‘Fleuve Manche’ palaeoriver and/or of a reduced seaward transfer of sediments from the shelf to the margin. However, two episodes of turbiditic activity increase were detected in the Celtic–Armorican margin, during Heinrich events (HE) 3 and 2. This strengthening of the turbiditic activity was triggered by the meltwater releases from European ice sheets and glaciers favouring the seaward transfer of subglacial material, at least via ‘Fleuve Manche’ palaeoriver. At around 20 cal ka, a significant increase of turbidite deposit frequency occurred as a response to the onset of the last deglaciation. The retreat of the European ice sheets and glaciers induced a substantial increase of the ‘Fleuve Manche’ palaeoriver discharges and seaward transfer of continentally-derived material into the Armorican turbidite system. The intensification of the turbiditic activity on the Celtic system was directly sustained by the widespread transport of subglacial sediments from the British–Irish Ice Sheet (BIIS) to the Celtic Sea via the Irish Sea Basin. A sudden reduction of turbiditic activity in the Armorican system, between ca. 19 and 18.3 cal ka, could have been triggered by the first well known abrupt sea-level rise (‘meltwater pulse’, at around 19 cal ka) favouring the trapping of sediment in the ‘Fleuve Manche’ palaeoriver valleys and the decrease of the seaward transfer of continentally-derived material. The maximum of turbiditic activity strengthening in the Celtic–Armorican margin, between ca. 18.3 and 17 cal ka, was induced by the decay of European ice sheets and glaciers producing the most extreme episode of the ‘Fleuve Manche’ palaeoriver runoff and a great seaward transfer of subglacial material into the Bay of Biscay. Between ca. 17.5 and 16 cal ka, the turbiditic activity significantly decreased in both Celtic and Armorican turbidite systems in response to a global re-advance of glaciers and ice sheets in Europe. The last episode of ice sheet retreat, between ca. 16 and 14 cal ka, is well expressed in the Celtic system by a new increase of the turbiditic activity. The major episode of sea-
Welvaart en leefomgeving : Een scenariostudie voor Nederland in 2040

Bespreking van: L.H. J.M. Janssen,Welvaart en leefomgeving. Een scenariostudie voor Nederland in 2040 Den Haag:Centraal Planbureau, Milieu- en Natuurplanbureau en Ruimtelijk Planbureau ,2006 90-6960-149-4
Adoption of cloud computing in emerging countries: the role of the absorptive capacity

This paper aims at developing a theoretical framework that explains the decision of cloud computing (CC) adoption in Emergent Countries. It emphasizes the specific role of the technological absorptive capacity especially when the firm is seeking innovation by adopting CC. The absorptive capacity considered in this work is close to the work of Todorova and Durisin (2007) who proposed a framework linking both the contributions of Cohen and Levinthal (1989) and Zahra and Georges (2002). To test our theoretical claims, we estimated two models predicting the probability of adopting CC and adopting CC for innovative aims with (1) competitive pressure and external environment, (2) Technology perceived impacts, and (3) technological absorptive capacity of the firm. We use control variables such as size, sector of activity and seniority in order to control the general purposes of our claims. We use a bivariate probit model in order to understand the determinants of the decision of adoption and an ordered probit with sample selection in order to understand the determinant of adoption of CC for innovative aims. Based on a face-to-face questionnaire administered to a random sample of 350 Tunisian firms, and using a Heckman selection method. Our empirical findings confirm our theoretical claims and show that technology perception is key factor for CC adoption (for general purposes) and that the absorptive capacity is fundamental when the adoption of CC is for innovation goals.We found also that competition pressureis an important explanatory factor:the more competitors that adopt this technology, the more likely the firm adopt it.
Rates of presurgical underestimation of breast cancer after standardized assessment of breast calcifications

Abstract Purpose: To determine the frequency of histopathological underestimation of breast cancer after vacuum-assisted biopsy (VAB) in standardized assessment of breast calcifications compared to postsurgical diagnosis. Materials and methods: The retrospective study included acquired data of 506 consecutively examined women, who underwent VAB for the assessment of pure calcifications after standardized digital mammographic and sonographic imaging. 119/506 (24.5 %) women underwent further surgical procedures: 37 women had a surgical diagnostic excision biopsy, 82 women a surgical procedure based on a therapeutic concept. Presurgical results of VAB were compared with the postsurgical histopathological reports. Results: In 91/119 women (76.5 %) the final histology was malignant. The rate of ductal carcinoma in situ (DCIS) was 79.1 % (72/91) and the rate of invasive carcinoma was 20.9 % (19/91). In 9/37 women with diagnostic excision biopsy, the presurgical status of benign or uncertain changed to a postsurgical diagnosis of malignant (24.3 %). In eight cases underestimation included DCIS (21.6 %) and in one case invasive cancer (2.7 %). Seven of the nine underestimated cases (77.8 %) resulted from excision biopsy of atypical epithelial proliferation of ductal type (AEPDT, positive predictive value 30.4 % (7/23)). After surgery due to DCIS in 7/71 women invasive breast cancer was diagnosed (9.9 %). In 11/82 women with oncological surgery, invasive cancer was already diagnosed by VAB. Conclusion: Underestimation of invasive cancer in terms of presurgical DCIS diagnosis can be minimized by the standardized assessment protocol to about 10 %. Underestimation of DCIS is mainly related to presurgical diagnosis of AEPDT. Key points: The standardized use of digital mammographic and sonographic imaging prior to vacuum-assisted biopsy is suitable for minimizing underestimation of invasive breast cancer. AEPDT represents a high risk diagnosis for underestimation of DCIS.
Theoretical and Empirical Properties of Foreign Exchange Risk Premia

We study the properties of foreign exchange risk premia that can explain the forward bias puzzle { the tendency of high-interest rate currencies to appreciate rather than depreciate. These risk premia arise endogenously from the no-arbitrage condition we impose on the relation between the term structure of interest rates and exchange rates, and they compensate for both currency risk and interest rate risk. In our empirical analysis, we estimate risk premia using an ane multi-currency term structure model and
Two regulatory fim genes, fimB and fimE, control the phase variation of type 1 fimbriae in Escherichia coli.

The expression of type 1 fimbriae in Escherichia coli is phase dependent, i.e. a cell is either completely fimbriated or bald. This phenomenon is due to the periodic inversion of a specific 300‐bp DNA segment containing the promoter for the fimbrial subunit gene, fimA. The phase switch is controlled by the products of two regulatory genes, fimB and fimE, located upstream of fimA. The fimB and fimE proteins direct the phase switch into the ‘on’ and ‘off’ position, respectively. The DNA sequence of a 3000‐bp region containing the two genes has been determined. The fimB and fimE proteins exhibit strong homology and have most likely originated by duplication of an ancestral gene. They are highly basic implying that they control the phase switch through interaction at the DNA level.
Innovation`s effect on brand equity: Insights from medical tourists

A market-innovative firm is presumed to have superior customer-linking values, which, in turn, is likely to lead fulfillment of superior subjective brand performance in comparison with non-innovative firms. However, empirical evidence for the argument prior knowledge is weak. Therefore, this study examines the influence of innovation capabilities on brand equity building in the medical tourism sector in Jordan. Accordingly, 384 questionnaires were systematic randomly distributed to treated medical tourists at five largest private hospitals in Amman city. Only, 306 questionnaires were used for data analysis. The findings showed that innovation contributes significantly to brand equity building. More specifically, product innovation, process innovation, and service innovation positively and significantly enhance overall brand equity. Meanwhile, administrative innovation and marketing innovation insignificantly affect overall brand equity.