Miracle-dz/UniFAR-FTUs huggingface dataset:
Protective effects of celastrol against γ irradiation-induced oxidative stress in human umbilical vein endothelial cells

High-dose ionizing radiation can cause harmful effects on the cardiovascular system. Notably, endothelial cells are critical targets in radiation-induced damage. γ radiation exerts its biological effects through the radiolysis of water, which further generates ROS and induces lipid peroxidation and DNA damage. The present study aimed to evaluate the potential protective effects of celastrol against γ radiation-induced oxidative stress in human umbilical vein endothelial cells (HUVECs). HUVECs were exposed to γ radiation at different doses with or without celastrol treatment. Cell viability and cytotoxicity, migratory ability, ROS production, lipid peroxidation, oxidative DNA damage and antioxidative enzyme levels were evaluated in HUVECs at 24 h post-irradiation. It was observed that HUVECs exhibited decreased cell viability, increased cytotoxicity and a decreased migratory ability after exposure to 20-Gy γ radiation. Celastrol treatment concentration-dependently reversed these effects. γ irradiation was also demonstrated to increase the production of ROS, enhance lipid peroxidation and oxidative DNA damage and decrease the levels of SOD, catalase, GST and GPx in HUVECs. These detrimental effects were blocked by treatment with celastrol for 24 h. These data suggested that celastrol not only attenuated γ radiation-induced cytotoxicity, but also effectively blocked oxidative stress in HUVECs. As an antioxidant agent, celastrol may have potential protective effects in HUVECs against γ irradiation-induced injury.
A Dual Inductor High Step-Up DC/DC Converter Based on the Cockcroft–Walton Multiplier

A new nonisolated, high step-up dc–dc converter is proposed based on the current-fed Cockcroft–Walton Voltage Multiplier (CW-VM) that can be used as the boosting power stage of converter for low-voltage low power renewable energy sources such as photovoltaic and fuel cells. The proposed converter employs two low-voltage common-emitter switches. Utilizing the current-fed CW-VM eliminates some problems associated with the conventional voltage-fed type such as voltage ripple and load-dependent voltage droop. Other advantages of the proposed converter are continuous input current, high voltage gain, and high efficiency. Steady state operation principles, specifications, and design considerations of the proposed converter are illustrated. Furthermore, efficiency analysis of the converter is performed and discussed. Experimental tests for a 200 W prototype are carried out which confirm the theoretical analysis.
Multivariable Temperature Control of a Heated Rod by Using a Reduced-Order Internal MIDR-Model

In this contribution, a tracking control design based on a reduced-order internal model control (IMC) approach is proposed for the temperatures at two selected points of a spatially one-dimensional iron rod. The rod is equipped with four Peltier elements on the lower surface, where the first and the third ones are employed as distributed control inputs. The method of integro-differential relations in combination with a projection approach yields a state-space model of order nine. After a balanced model-order reduction, which results in a model order of four, an observer-based IMC is designed with an approximate inverse system model. The time lag behaviour of the IMC structure can be addressed by a dynamical feedforward control that improves the tracking behaviour further. An implementation at a test rig at the Chair of Mechatronics, University of Rostock, points out that an acceptable decoupling of both outputs and an accurate tracking of desired trajectories can be achieved with the proposed control structure.
Antitumor necrosis factor-α antibodies as a noveltherapy for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) accounts for many cases of cancer-associated mortality. Tumor necrosis factor (TNF)-α is a key mediator of tumor-promoting inflammation. It has been demonstrated that anti-TNF-α treatments have preclinical benefits for multiple types of cancer, however their potential for treating HCC remains unclear. Through fluorescence-activated cell sorter analysis and enzyme-linked immunosorbent assay, the results of the current study indicated that TNF-α was strongly expressed in HCC tissues and the HCC cell lines HepG2 and Hep3B. In vitro, anti-TNF-α antibodies (infliximab and etanercept) decreased HCC cell viability via antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity effects. Infliximab treatment also significantly increased apoptosis in HepG2 and Hep3B cells compared with controls (P<0.001 and P<0.05, respectively). In vivo, anti-TNF-α treatment delayed HCC progression as indicated by the significantly prolonged survival time in an HCC xenograft mouse model (P=0.0009). Further analyses revealed that anti-TNF-α treatment significantly decreased the expression of pro-inflammatory cytokines, including TNF-α (P<0.01), interleukin (IL)-1β (P<0.05), IL-6 (P<0.05) and IL-17 (P<0.05) and induced apoptosis in HCC tumors. The results of the current study suggest that TNF-α is a potential target for novel therapeutic strategies to treat HCC. Anti-TNF-α treatments compromised HCC tumor progression by inducing cell death and decreasing levels of pro-inflammatory cytokines.
Spontaneous and directed symmetry breaking in the formation of chiral nanocrystals

Significance Processes which break symmetry have always attracted the interest of scientists, as they are at the heart of many natural phenomena, from particle physics to biology. In life, the mirror symmetry breaking of biomolecules has been the subject of extensive debate and theoretical modeling. Hence, well-controlled model systems which break chiral symmetry are of great interest. We report on chiral amplification in the formation of chiral inorganic nanocrystals, leading to random breaking of mirror symmetry below a critical temperature. This symmetry breaking can be sensitively directed to a particular handedness by specific chiral biomolecules. The observed symmetry breaking is analyzed as a phase transition analogous to the ferromagnetic–paramagnetic transition in metals. Symmetry plays a crucial part in our understanding of the natural world. Mirror symmetry breaking is of special interest as it is related to life as we know it. Studying systems which display chiral amplification, therefore, could further our understanding of symmetry breaking in chemical systems, in general, and thus also of the asymmetry in Nature. Here, we report on strong chiral amplification in the colloidal synthesis of intrinsically chiral lanthanide phosphate nanocrystals, measured via circularly polarized luminescence. The amplification involves spontaneous symmetry breaking into either left- or right-handed nanocrystals below a critical temperature. Furthermore, chiral tartaric acid molecules in the solution direct the amplified nanocrystal handedness through a discontinuous transition between left- and right-handed excess. We analyze the observations based on the statistical thermodynamics of critical phenomena. Our results demonstrate how chiral minerals with high enantiopurity can form in a racemic aqueous environment.
Benefits and risks of JAK inhibition.

On 16 November 2011, the US Food and Drug Administration (FDA) approved ruxolitinib, a small-molecule inhibitor of JAK1/2, for the treatment of patients with intermediate- or high-risk myelofibrosis, including primary myelofibrosis, post–polycythemia vera myelofibrosis, and post–essential thrombocythemia myelofibrosis. In this issue of Blood , Porpaczy et al report findings of a study showing that JAK1/2 inhibitor treatment is associated with an increased risk for aggressive B-cell lymphomas. 1
Sequential Change Detection Through Universal Compression - An Asymptotic Study

This paper studies the asymptotic performance of a modified version of Page's sequential change detection algorithm based on universal compression. Such a class of change detection algorithms was first introduced by Jacob and Bansal in [1] where the authors studied the performance of the modified test under Lorden's minimax framework. This paper is motivated by the monograph [2] of Lai, which introduced a host of criteria for gauging the performance of change detection tests. We consider the performance of the modified test under one such criteria namely a constraint on the probability of false alarm within a window and establish that asymptotically the modified test is equivalent to Page's Cumulative Sum Test (CUSUM).
Coordination Aspects of an Effective Sprint Start

The aim of the present study was to examine differences in the movement structure and the coordination aspects expressed by bioelectrical tension indicators between a group of experts/sprinters and a group of novices/students. A group consisted of 20 sprinters and a control group consisted of 35 master’s physical education students. A 16-channel surface electromyography (14 muscles) and two cameras with recording speed of 250 frames/per second were used. Significant differences were found between reaction time (p < 0.005) and time at 30 m of the covered sprinting distance (p < 0.001) between the students and advance athletes. Furthermore, the sprinters activated the back foot (taking off the starting blocks) and the front foot (first ground contact) earlier, which correlated with the attained times at 5 (r = 0.66) and 10 m (r = 0.62) of the covered sprinting distance. The most important component of the sprint start, apart from the muscle strength of the legs, is the appropriate motor coordination, which greatly affects the generation of power in the legs at the right time and optimal duration.
A Conceptual Framework for Creating and Analyzing Dance Learning Digital Content

As they are mainly based on bodily experiences and embodied knowledge, dance and movement practices present a great diversity and complexity across genre and context. Thus, developing a conceptual framework for archiving, managing, curating and analysing movement data, in order to develop reusable datasets and algorithms for a variety of purposes, remains a challenge. In this work, based on relevant literature on movement representation and existing systems such as Laban Movement Analysis, as well as working with dance experts through workshops, focus groups, and interviews, we propose a conceptual framework for creating, and analysing dance learning content. The conceptual framework, has been developed within an interdisciplinary project, that brings together technology and human computer interaction researchers, computer science engineers, motion capture experts from industry and academia, as well as dance experts with background on four different dance genres: contemporary, ballet, Greek folk, and flamenco. The framework has been applied: a) as a guidance to systematically create a movement library with multimodal recordings for dance education, including four different dance genres, b) as the basis for developing controlled vocabularies of dance for manual and automated annotation, and c) as the conceptual framework to define the requirements for similarity search and feature extraction.
Extracorporeal membrane oxygenation in trauma: A single institution experience and review of the literature

Introduction: Limited options exist for cardiovascular support of the trauma patient in extremis. This patient population offers challenges that are often considered insurmountable. This article identifies a heterogeneous group of trauma patients in extremis who may benefit from extracorporeal membrane oxygenation. Methods: Data were sourced from the medical records of all patients placed on extracorporeal membrane oxygenation following trauma at a Level I Trauma Center between 1 December 2016 and 1 December 2017. Results: All patients were male (N = 7), mostly with blunt injuries (n = 5), with an average age of 41 years and with an average Injury Severity Scores of 33 (median = 34). Two out of seven patients survived (28.5%). Survivors tended to have a longer duration on extracorporeal membrane oxygenation (13.5 vs 3.8 days), had extracorporeal membrane oxygenation initiated later (15 vs 7.8 days), and had suffered a blunt injury. Two patients were initiated on veno-arterial extracorporeal membrane oxygenation (both non-survivors) and five were initiated on veno-venous extracorporeal membrane oxygenation (two survivors, three non-survivors). Five patients were heparinized immediately (one survivor, four non-survivors), and two patients were heparinized after clotting was noted in the circuit (one survivor, one non-survivor). Three of the seven (42.8%) patients suffered cardiac arrest either prior to, or during, the initiation of extracorporeal membrane oxygenation (all non-survivors). Discussion: Extracorporeal membrane oxygenation use in the trauma patient in extremis is not standard; however, this article demonstrates that extracorporeal membrane oxygenation is feasible in a complex, heterogeneous patient population when treated at designated centers.
Takotsubo Cardiomyopathy-Induced Cardiac Free Wall Rupture: A Case Report and Review of Literature

Takotsubo cardiomyopathy (TCM) is an acquired form of cardiomyopathy that is commonly seen among post-menopausal women. It is characterized by left ventricular apical ballooning, electrocardiographic changes and mild elevation of cardiac enzymes in the absence of significant coronary artery stenosis. TCM usually has benign course. However, on rare instance, it can result in life-threatening and fatal complications including acute cardiogenic shock, ventricular arrhythmias and ventricular wall rupture. We herein report a case of a 77-year-old female who developed TCM complicated with massive pericardial effusion and cardiac arrest. The patient died and autopsy revealed normal coronaries with a slit-like rupture on the antero-apical surface of the heart extending into the papillary muscle. The clinical course, labs and angiographic findings preceding the cardiac rupture will be outlined. A thorough literature review including review of 14 previously reported case reports of TCM complicated with cardiac rupture will be included.
Partially Isolated Single-Magnetic Multiport Converter Based on Integration of Series-Resonant Converter and Bidirectional PWM Converter

Recent power systems, such as renewable energy systems consisting of solar panels and rechargeable batteries, contain multiple power sources and need multiple converters in proportion to the number of power sources, resulting in increased system complexity and cost. This paper proposes a multiport converter (MPC) integrating a bidirectional PWM converter and series-resonant converter. Not only is the switch count halved with the proposed MPC, but also magnetic components can be integrated, reducing the circuit complexity and volume. A 150-W prototype of the proposed MPC was built for the experimental verification. The measured voltage conversion characteristics and transient responses demonstrated that the proposed MPC could control load and battery voltages independently by pulse width modulation and pulse frequency modulation controls, respectively.
Multiple Hypothesis Testing in Adversarial Environments: A Game-theoretic Approach

This paper considers hypothesis testing using multiple sensors, among which some might be compromised and send arbitrary data. There exist no less than two hypotheses, which is an extension of the binary hypothesis testing in our recent work [1]. The exponent rate, under which the worst-case probability of detection error goes to zero, is adopted as the performance metric. The problem is formulated in a game theoretic way and an equilibrium pair of attack and detection strategies is given. We also provide a simplified equilibrium detection algorithm when the mean of Gaussian noises is to be determined. Two extensions are also studied and a Nash equilibrium is provided for each case using a similar methodology. In the first extension, composite hypothesis testing is studied, i.e., the distribution of observations under each hypothesis is not known exactly but is characterized by a (unknown) parameter. In the second one, heterogeneous sensors are used to collect measurements.
Sememe Prediction: Learning Semantic Knowledge from Unstructured Textual Wiki Descriptions

Huge numbers of new words emerge every day, leading to a great need for representing them with semantic meaning that is understandable to NLP systems. Sememes are defined as the minimum semantic units of human languages, the combination of which can represent the meaning of a word. Manual construction of sememe based knowledge bases is time-consuming and labor-intensive. Fortunately, communities are devoted to composing the descriptions of words in the wiki websites. In this paper, we explore to automatically predict lexical sememes based on the descriptions of the words in the wiki websites. We view this problem as a weakly ordered multi-label task and propose a Label Distributed seq2seq model (LD-seq2seq) with a novel soft loss function to solve the problem. In the experiments, we take a real-world sememe knowledge base HowNet and the corresponding descriptions of the words in Baidu Wiki for training and evaluation. The results show that our LD-seq2seq model not only beats all the baselines significantly on the test set, but also outperforms amateur human annotators in a random subset of the test set.
Clinical significance of optical coherence tomography-guided angioplasty on treatment selection

The present study aimed to observe whether optical coherence tomography (OCT)-guided angioplasty is able to provide useful clinical information beyond that obtained by angiography as well as provide recommendations for physicians that may improve treatment selection. This prospective study included 83 patients with coronary artery disease (>18 years) undergoing coronary angiography (CAG) for ST-elevation myocardial infarction (n=13), non-ST-elevation myocardial infarction (n=19), stable angina (n=22), unstable angina (n=10), silent ischemia (n=11), or elective percutaneous coronary intervention (n=8). Following the initial CAG (CAG-pre), the patients underwent OCT before angioplasty (OCT-pre, 24 patients), after angioplasty (OCT-post, 22 patients), or both (37 patients). The thrombus burden, calcification and plaque dissection or rupture were compared between the OCT-pre and CAG-pre recordings. Following angioplasty, stent malapposition, suboptimal stent deployment, suboptimal stent lesion coverage, and edge dissection were compared between OCT-post and CAG-post alone. Among the 83 patients, 45.7% had single-vessel and 54.3% had multiple-vessel disease. OCT pre- and post-angioplasty revealed significantly more information on the procedure than CAG alone. This clinical information changed the clinical strategies in 41/83 (49.4%) patients, including 58 modifications of therapeutic strategy (69.9%, 58/83): Thrombus aspiration in 2 cases (2.4%), administration of glycoprotein IIb/IIIa inhibitors in 8 cases (9.6%), additional balloon inflation in 23 cases (27.7%), additional stent implantation in 17 cases (20.5%), avoiding stent implantation in 4 cases (4.8%), collateral intervention in 2 cases (2.4%), and guidewire reposition in 2 cases (2.4%). In conclusion, OCT-pre and OCT-post provided additional clinical information beyond that obtained by angiography alone, which resulted in modification of the treatment strategies in half of the included patients.
New Corticopontine Connections in the Primate Brain: Contralateral Projections From the Arm/Hand Area of the Precentral Motor Region

The ipsilateral corticopontine projection (iCPP) represents a massive descending axon system terminating in the pontine nuclei (PN). In the primate, this projection is well known for its dominant influence on contralateral upper limb movements through the classical cerebrocerebellar circuity system. Although a much weaker contralateral corticopontine projection (cCPP) from motor cortex to the paramedian region has been reported in the non-human primate brain, we provide the first comprehensive description of the cCPP from the lateral motor cortex using high resolution anterograde tract tracing in Macaca mulatta. We found a relatively light cCPP from the hand/arm area of the primary motor cortex (M1), comparatively moderate cCPP from ventrolateral premotor cortex (LPMCv) and a more robust and widespread cCPP from the dorsolateral premotor cortex (LPMCd) that involved all nine contralateral PN. The M1 projection primarily targeted the dorsal pontine region, the LPMCv projection targeted the medial pontine region and LPMCd targeted both regions. These results show the first stage of the primate frontomotor cerebrocerebellar projection is bilateral, and may affect both ipsilateral and contralateral limbs. Clinically, the cCPP originating in the non-injured hemisphere may influence the recovery process of the more affected upper extremity following subtotal unilateral damage to the lateral cortical region. The cCPP may also contribute to the mild impairment of the upper limb contralateral to a unilateral cerebellar injury.
Long non-coding RNA TUG1 promotes osteosarcoma cell proliferation and invasion through inhibition of microRNA-212-3p expression

Taurine upregulated gene 1 (TUG1), a long non-coding RNA (lncRNA), has recently been suggested to be associated with the development of osteosarcoma (OS), but the underlying molecular mechanism still remains largely unclear. In the present study, it was revealed that TUG1 was significantly upregulated whereas miR-212-3p was significantly downregulated in OS tissues and cell lines, when compared with adjacent non-tumor tissues and normal osteoblasts cell lines, respectively. An inverse association between the TUG1 and miR-212-3p expression was also observed in OS tissues. Furthermore, TUG1 directly interacted with miR-212-3p and negatively regulated the expression of miR-212-3p in OS cells. In vitro experiments further indicated that inhibition of TUG1 suppressed the proliferation and invasion of OS cells. Furthermore, knockdown of miR-212-3p eliminated the suppressive effects of TUG1 inhibition on the proliferation and invasion of OS cells. Taken together, these findings demonstrate that TUG1 promotes OS cell proliferation and invasion by inhibition of miR-212-3p expression, thus suggesting that TUG1 may become a potential therapeutic target for OS.