Miracle-dz/UniFAR-FTUs huggingface dataset:
Low-Grade Endometrial Stromal Sarcoma and Uterine Adenosarcoma: A Comparison of Clinical Manifestations and Outcomes

Objective: Our study aimed to assess factors associated with progression free survival (PFS) and overall survival (OS) in low grade endometrial stromal sarcoma (LG-ESS) and uterine adenosarcoma, and to determine the differences in clinical manifestations and outcomes between the two diseases. Methods: A total of 132 patients were enrolled in this retrospective study at Peking Union Medical College Hospital from 1998 to 2016. The associations of clinical and pathological factors with PFS and OS were evaluated. Results: Of the 132 included patients, 104 had LG-ESS and 28 had uterine adenosarcoma. All patients were followed up for at least 1.5 years. There were significant differences between LG-ESS and uterine adenosarcoma in terms of age distribution (41.05±10.5 vs 46.11±14.96 years, P=0.042), delivery time (nulliparity=0: 18.27% vs 35.71%, P=0.046), history of the uterine leiomyoma (65.38% vs 39.29%, P=0.012), and polypoid tumor growth (14.42% vs 60.71%, P=0.007). According to the pathological findings, the proportion of uterine adenosarcoma patients with uterine leiomyoma (60.71%) was significantly higher than that for the LG-ESS patients (32.69%) (P=0.007). Uterine adenosarcoma seemed to be associated with longer PFS and OS than LG-ESS (PFS: 42.69±29.94 vs 50.50±40.50 months; OS: 58.72±37.29 vs 69.46±47.58 months), but the differences were not statistically significant. Multivariate Cox regression showed that age, menopause, history of uterine leiomyoma, stage, and hormone therapy were independent risk factors with respect to PFS, whereas age and stage were risk factors affecting OS in LG-ESS patient. Peritoneal lavage cytology and radiotherapy were risk factors affecting PFS and peritoneal lavage cytology for OS in patients with uterine adenosarcoma. Conclusion: The patients with advanced LG-ESS had poor prognosis. Age and history of uterine leiomyoma were associated with poor PFS, while menopause and hormone therapy were protective factors associated with improved PFS in patients with LG-ESS. Peritoneal lavage cytology and radiotherapy did not improve prognosis of uterine adenosarcoma.
Clinical profile of pancytopenia: a tertiary care experience

This study was done to document the clinico-hematological profile of pancytopenia in adult patients. A total of 53 cases of pancytopenia were diagnosed during the period of Jan 2012 to Dec 2012. Full blood count was performed in all the cases. Clinical variables were recorded for each patient. Out of 53 cases 29 were male. The mean age of patients was 35.15±12.6 years. Pallor and fever were the main presenting symptoms. The main etiological cause of pancytopenia in our case series was megaloblastic anaemia followed by septicaemia and alcoholic and non-alcoholic liver disease. Early identification of the underlying conditions would help in understanding the disease process, and early planning for further investigations and management will enhance survival rate of a case with pancytopenia.
New method for discriminating 4 D time shifts in the overburden and reservoir

Understanding seismic changes in the subsurface is important for reservoir management and health, safety and environmental (HSE) issues. Typically the changes are interpreted based on the time shifts in seismic time-lapse (4D) data, where sources are at the surface and receivers are either at the surface or in a borehole. With these types of acquisition geometry, it is more straightforward to detect and interpret changes in the overburden, close to the source and receivers, than changes in the deeper part close to the reservoir, because the time shift is accumulative along its ray path from source to receiver. We propose a new method for reconstructing the reflection responses of the overburden and the reservoir, separately, for 4D time shift analysis. This method virtually moves sources and receivers to a horizontal borehole level, which enables a more direct interpretation of the time shifts to the changes close to the borehole, instead of to the surface. A realistic field model is used to demonstrate the method, and we observe a clear discrimination of the different time shifts in the overburden and reservoir, which is not obvious in the original datasets.
554 CMOD 5 . N : A C-band geophysical model function for equivalent neutral wind

This document describes the evaluation of a C-band geophysical model function. This model function, called CMOD5.N, is to provide an empirical relation between C-band backscatter as sensed by the space-born ERS-2 and ASCAT scatterometers, and equivalent neutral ocean vector wind at 10-metre height (neutral surface wind) as function of (scatterometer) incidence angle. CMOD5.N embodies a refit of CMOD5, a C-band model function which was previously derived to obtain non-neutral surface wind, in such a way that its 28 tuneable coefficients lead, for given backscatter observation, to an enhancement of 0.7ms−1 in wind speed. The value of 0.7ms−1 is chosen to be independent on wind speed and incidence angle, and incorporates the average difference between neutral and non-neutral wind (∼ 0.2ms−1 ) and for a known bias of CMOD5 (∼ 0.5ms−1 ) when compared to buoy wind data. The quality of the CMOD5.N fit is tested for the AMI scatterometer on ERS-2 and ASCAT instrument on METOP-A for July 2007 and January 2008. From this it is found that winds inverted with CMOD5.N are on average 0.69ms−1 stronger than winds determined from CMOD5. As function of wind speed and incidence angle, fluctuations are well within 0.05ms−1 . Differences in wind direction are small. ASCAT and ERS-2 wind speed obtained from CMOD5.N compares on average well with operational neutral wind from the European Centre for Medium-Range Weather Forecasts (ECMWF). In comparison with nonneutral wind, local, seasonally dependent biases between scatterometer and ECMWF model are reduced. Besides effects introduced by orography and ocean currents, a residual stability-dependent bias between scatterometer and neutral wind remains, which is likely connected to a previously reported non-optimality in the ECMWF boundary layer formalism by Brown et al. in 2006. The work presented in this document is funded by ESRIN (Project Ref. 18212/04/I-OL).
Transcriptomic and proteomic profiles of vascular cells involved in human abdominal aortic aneurysm

Abdominal aortic aneurysms (AAAs) are a potentially fatal disorder. Atherosclerotic changes followed by accelerated degradation of collagen and elastin, the main components of the extracellular matrix (ECM) in the vascular wall, cause the development of AAAs in deteriorating aortic walls that dilate progressively and may eventually rupture. Other alterations associated with AAAs include marked changes in the cellular composition of the aortic wall, especially the infiltration of macrophages and T-lymphocytes into the adventitia and a major reduction in the population of vascular smooth muscle cells (SMCs) (LopezCandales et al., 1997; Henderson et al., 1999). AAA appear to be a consequence of complex mechanisms involving several potential factors: immunological, inflammatory, chemotactic, apoptotic, protease-related, angiogenic and fibrinolytic (Ailawadi et al., 2003). Recently, interleukin-8 and monocyte chemoattractant protein 1 expression were shown to be raised in the AAA biopsies compared to the abdominal aorta of controls, suggesting that pathways involving these proteins may be involved in AAA pathologies (Middleton et al., 2009). AAA is a disease associated with chronic inflammation in the aortic wall and leukotrienes are powerful lipid mediators released by inflammatory cells (Samuelsson, 1983). A recent study showed the increased expression of leukotriene C4 synthase together with the predominant formation of cysteinyl-leukotrienes in human AAA, linked with matrix metalloproteinases (MMP)
The MACC Global Fire Assimilation System : First Emission Products ( GFASv 0 )

The D-FIRE sub-project of MACC is producing real time fire emissions with a Global Fire Assimilation System (GFAS). The emissions will be used by the regional and global forecast production systems in MACC. The first version of the fire emission products, GFASv0, is based on the GEMS fire emission product but is scaled such that it reproduces the global annual emission budget of the GFEDv2 inventory. Preliminary comparisons of modelled smoke plumes with other systems’ smoke plumes indicates that the GFASv0 products are applicable for fire plume forecasting. They are released with a previously agreed interface that consists of archiving in the MARS database of regular latitude-longitude emission fields for several species with 0.1 deg spatial resolution and 1 hour temporal resolution. The release enables the MACC partners to implement and technically test the interface. Furthermore, the fire emissions may already be used in the MACC forecasting systems after testing their effect on the particular system’s forecasting skill. Feedback on the product interface as well as its performance in forecasting applications is encouraged.
Propalaeocastor (Rodentia, Mammalia) from the Early Oligocene of Burqin Basin, Xinjiang

Abstract A new species of castorids, Propalaeocastor irtyshensis, n.sp. , from the Burqin Basin of Xinjiang Uygur Autonomous Region, China, is described. The new species, represented by a right maxilla with well-preserved P4–M3, is the earliest and northernmost occurrence of castorids in China. It is characterized mainly by the cheek tooth crown being higher than that of P. butselensis but lower than that of Steneofiber aff. dehmi (probably a new species of Propalaeocastor), and by lingual confluence of the mesoflexus to the lingual fossette of the premesoflexus. Comparison with known species previously assigned to Steneofiber from Europe and Kazakhstan leads to the conclusion that the early Oligocene forms previously assigned to the genus, such as “S. butselensis” and “S. kazachstanicus”, differ significantly from those represented by S. eseri from the Late Oligocene and Early Miocene of Europe. We consider Propalaeocastor a valid genus, provide an emended diagnosis for it, and discuss its evolutionary trend in relation to Steneofiber. Preliminary analysis of Burqin fauna suggests an age of early Early Oligocene. Faunal transformations across the Eocene–Oligocene boundary in the Burqin region are comparable to those of Europe and the Mongolian Plateau and suggest linkage of faunal turnovers and global climate changes.
Primary Signet-Ring Cell Carcinoma of the Prostate : A Review of the Literature

Primary and metastatic signet-ring-cell carcinoma of the prostate are rare, in view of this a number of clinicians may be unfamiliar with the disease entity. Both Primary and secondary metastatic signet-ring-cell carcinomas of the prostate (SRCCP) are rare and less than 200 cases of primary SRCCP have been reported. Primary SRCCP may be found incidentally; may present with lower urinary tract symptoms or just raised serum PSA levels; may present as mass/nodule in prostate; may be diagnosed in the investigation for primary cause of a metastasis. Diagnosis is based upon finding of adenocarcinoma of prostate with signet-ring cells on microscopic examination of prostate (usually high grade and more than 25% of signet-ring cells in tumour these days though previously 5 to 50% have been reported). Primary SRCCP stains positively with PSA and PAP. Diagnosis of primary SRCCP is established after excluding possible primary lesions elsewhere. Primary SRCCP can be treated by hormonal therapy, radiotherapy, surgery and chemotherapy but previous reports indicated poor prognosis with low-long term cancer-specific survival but a recent report had indicated an improved outcome but still the outcome for the younger age group was inferior. There is no consensus on the best treatment approach to further improve on prognosis. Primary SRCCPs tend to be high-grade/undifferentiated with poor prognosis; Recent data, had indicated improved survival but poor survival in younger patients. New cases of primary SRCCP should be entered into a multi-center trial to decide on the best treatment options and to find out if the prognosis would be influenced by the percentage of signet-ring cells. There is need to have a consensus opinion on the minimum proportion of signet-ring cells in a prostatic tumour that would constitute primary SRCCP.
Star formation in quasar hosts and the origin of radio emission in radio-quiet quasars

Radio emission from radio-quiet quasars may be due to star formation in the quasar host galaxy, to a jet launched by the supermassive black hole, or to relativistic particles accelerated in a wide-angle radiatively-driven outflow. In this paper we examine whether radio emission from radio-quiet quasars is a byproduct of star formation in their hosts. To this end we use infrared spectroscopy and photometry from Spitzer and Herschel to estimate or place upper limits on star formation rates in hosts of ~300 obscured and unobscured quasars at z<1. We find that low-ionization forbidden emission lines such as [NeII] and [NeIII] are likely dominated by quasar ionization and do not provide reliable star formation diagnostics in quasar hosts, while PAH emission features may be suppressed due to the destruction of PAH molecules by the quasar radiation field. While the bolometric luminosities of our sources are dominated by the quasars, the 160 micron fluxes are likely dominated by star formation, but they too should be used with caution. We estimate median star formation rates to be 6-29 Msun/year, with obscured quasars at the high end of this range. This star formation rate is insufficient to explain the observed radio emission from quasars by an order of magnitude, with log(L_radio, observed/L_radio, SF)=0.6-1.3 depending on quasar type and star formation estimator. Although radio-quiet quasars in our sample lie close to the 8-1000 micron infrared / radio correlation characteristic of the star-forming galaxies, both their infrared emission and their radio emission are dominated by the quasar activity, not by the host galaxy.
Cross-border mergers and acquisitions: Mature markets vs. emerging markets—with special reference to the USA and India

Abstract Due to the differences in the merger waves across markets, the market for cross-border mergers and acquisitions by Indian companies differs in context and situations from those of the mature markets. Post-acquisition performance is critical to the success of companies involved in overseas investments. This paper uses event study methodology to analyse the long-term performance of Indian-acquiring companies by undertaking 30 outward foreign direct investment (OFDI)-related deals, during 2000–2008 period. Further, it compares the empirical findings from India with the prior findings from the USA. It is evident from the empirical results that the stock markets reacted positively in the short run following the announcements of the OFDI-related mergers and acquisitions by Indian companies. The empirical findings also showed positive results in the post-acquisition period following the overseas deals.
A Study of the Anthropometric and Demographical Profile of Patients Presenting with Coronary Artery Disease at Mayo Hospital, Lahore

Coronary artery disease (CAD) is very common in the South Asian sub-continent, yet there is relatively little published rese-arch available from these countries. Although we have a very active Cardiology Department in Mayo Hospital, Lahore, there is a parallel need for documentation of the data generated and its analysis for research and publication. This study was carried out to gain an insight into the nature of the risk factors and presentation of CAD in patients coming to our setup. Objectives: The objective was to study the relation of CAD with anthropometric (BMI, waist circumference, waist – to – height ratio) and demographical (age and gender) factors. Methodology: This study was carried out in the Department of Cardiology, Mayo Hospital, Lahore, for a duration of 17 months. We collected the required information (such as name, gender, and family history, demographical data and anthro-pometric measurements) on a prescribed proforma, managed and then analyzed accordingly. Results: In this study there were 302 (80.5%) males and 73 (19.5%) females. The number of males was significantly higher (p-value 0.000), but the frequency of different diagnoses was statistically the same in both males and females, i.e. p-value = 0.062. According to the WHO recommended criteria for the BMI of South Asian populations, there were 9(2.4%) people who were under weight, among these 7 (77.8%) were males and 2 (22.2%) were females patients. Out of 302 males, 7(2.3%) were under weight, 36 (11.9%) were of normal weight, 115 (38.1%) were overweight and the rest of 144 (47.7%) were obese. Among 73 females, 2 (2.7%) were under weight, 8 (11%) had normal weight, 15 (20.5%) were overweight and 48 (65.8%) were obese. The proportion of obesity was more in females in this study, p-value (0.000). The mean waist circumference of all patients was 95.57 ± 17.14 cm with a range of 53 – 190 cm. The waist circumference was statistically higher in males than females, p-value = 0.000. In 7 under weight males, 6 patients had WC < 90 cm while one had ≥ 90 cm. Among 36 male patients of normal weight, 19 had WC < 90 and 17 had ≥ 90 cm, while in 115 over weight males 28 patients had WC < 90 cm and 87 had ≥ 90 cm. In 144 obese males 13 patients had WC < 90 cm and 131 had ≥ 90 cm. In males the mean waist to height ratio (WHtR) was 0.5789 ± 0.091 with the range (0.31 – 1.23) and in females it was 0.64 ± 0.11 cm with range (0.36 – 1.28). Conclusion: Obesity as a risk factor is significantly present in our patients of coronary heart disease, more so in females, in which it appears to be more central or abdominal in character as compared to males, although there is considerable central adiposity in males, too. There is an imperfect correlation between the various measures of obesity, i.e., BMI, WC and WHtR when applied to our patients. More than one parameter should be used to reduce the chances of missing cases. Key words: Heart Disease, Obesity, Risk Factors of Heart Disease.
Malignant Ovine Theileriosis: Alterations in the Levels of Homocysteine, Thyroid Hormones and Serum Trace Elements

Introduction: Malignant ovine theileriosis is a fatal disease of sheep caused by the pathogenic species of protozoans of the genus Theileria. This study was designed to estimate the levels of plasma homocysteine (Hcy), serum thyroid hormones, the serum trace elements and to evaluate their correlations in different parasitemia rates in naturally Theileria infected sheep. Materials and Methods: 50 Iranian sheep, about 1-2 years old, naturally infected with T. lestoquardi were selected and divided into 2 subgroups according to parasitemia rates (<2%, 2-4%). 10 non-infected animals were also selected as controls. Blood samples were collected and Hcy, thyroid hormones and major trace elements were measured. Results: Significant decrease in the values of red blood cell count (RBC), packed cell volume (PCV) and hemoglobin confirmed that anaemia had occurred in the infected sheep. Significant increase in Hcy and some trace elements (Mn, Fe and Zn), significant decrease in the values of thyroxine (T4) and free tri-iodothyronine (fT3) were observed. Conclusion: Substantial elevations in plasma Hcy can potentially produce endothelial injuries and consequently help the formation of anaemia. On the other hand, significant decrease in T4 and fT3 and increase in some trace elements (Mn, Fe and Zn) besides the lack of any changes in the other related factors, indicate that the infection of sheep with lower than 4% parasitemia rates, can induce negative effects on the secretion and concentrations of thyroid hormones, but the infection could not cause reverse effects on important trace elements.
Statistical properties of magnetic structures: Their dependence on scale and solar activity

A long data set of MDI/SOHO full-disk magnetograms is analyzed in order to provide a large sample of network features as well as active regions associated with their magnetic properties (magnetic flux and magnetic flux density for ex- ample). The main objective of the paper is to study the variations of these properties along the solar cycle, and to compare the behavior of the magnetic features at various scales (covering three orders of magnitude in size). I also investigate the de- pendence of these properties on the activity level in their neighborhood and in the context of their global configuration on the solar disk. This study is important for a better understanding of the emergence and decay of active regions, as well as of the role of the network in the removal of the magnetic flux and in solar irradiance variations. The main results are as follows. (i) I observe a characteristic scale in the range 400-800 Mm 2 (close to the supergranular scale) below which the size and magnetic flux distributions are power laws down to 40 Mm 2 (corresponding to the range 3 10 19 -10 21 Mx). This scale increases from solar minimum to solar maximum. The shape of the distributions also suggests a strong similarity between small active regions (below the supergranular scale) and network patches. (ii) The North-South asymmetry in the number of structures, compatible with easier-to-detect leading structures in most cases, surprisingly exhibits a sign reversal for the weakest structures, suggesting ad ierent origin, while the East-West asymmetry is compatible with a predominantly eastward inclination of magnetic flux tubes, including network structures and not only for emerging active regions as suggested by models. (iii) The dependence of the magnetic characterictics on the size of the structures is found to be variable with the activity level, the magnetic flux beeing more concentrated at solar maximum (especially for small features). Small-scale properties are also dependent on the proximity of an active region. (iv) Latitudinal distributions and flux variations along the solar cycle suggests a significant role of the meridional flows in the properties of the very small network features as well as an influence of supergranulation properties. (v) The variations of the magnetic properties of network elements and active regions with time are strongly size-dependent. The results also show a correlation between the number (or magnetic flux) of network structures and the sunspot cycle, with an amplitude larger than expected from previous results.