Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of vitamin A supplementation on haemoglobin and vitamin A levels during pregnancy

About 450 pregnant women from a low-income group were recruited to study the effect of vitamin A supplementation on plasma vitamin A levels in the mother and cord and on the birth weights of the neonates. Results showed that supplementation with 1800 μg vitamin A/d for more than 12 weeks prevented the decline in plasma vitamin A that otherwise occurs during the last few weeks of pregnancy. This improvement in maternal values for vitamin A at a critical time of development favourably affected availability to the fetus, as reflected by the marked elevation in cord levels. Supplementation for a period of 12 weeks was found to be sufficient, since subsequent discontinuation did not alter the beneficial response. Apart from increasing maternal and cord vitamin A levels, vitamin A supplementation along with iron prevented, in this study, the significant decline in haemoglobin occurring at 26–28 weeks of gestation. The birth weights were not altered by vitamin A supplementation.
SHORT‐TERM EFFECTS ON LOWER‐BODY FUNCTIONAL POWER DEVELOPMENT: WEIGHTLIFTING VS.VERTICAL JUMP TRAINING PROGRAMS

Among sport conditioning coaches, there is considerable discussion regarding the efficiency of training methods that improve lower-body power. Heavy resistance training combined with vertical jump (VJ) training is a well-established training method; however, there is a lack of information about its combination with Olympic weightlifting (WL) exercises. Therefore, the purpose of this study was to compare the short-term effects of heavy resistance training combined with either the VJ or WL program. Thirty-two young men were assigned to 3 groups: WL = 12, VJ = 12, and control = 8. These 32 men participated in an 8-week training study. The WL training program consisted of 3 × 6RM high pull, 4 × 4RM power clean, and 4 3 4RM clean and jerk. The VJ training program consisted of 6 × 4 double-leg hurdle hops, 4 × 4 alternated single-leg hurdle hops, 4 × 4 single-leg hurdle hops, and 4 × 4 40-cm drop jumps. Additionally, both groups performed 4 × 6RM half-squat exercises. Training volume was increased after 4 weeks. Pretesting and posttesting consisted of squat jump (SJ) and countermovement jump (CMJ) tests, 10- and 30-m sprint speeds, an agility test, a half-squat 1RM, and a clean-and-jerk 1RM (only for WL). The WL program significantly increased the 10-m sprint speed (p < 0.05). Both groups, WL and VJ, increased CMJ (p < 0.05), but groups using the WL program increased more than those using the VJ program. On the other hand, the group using the VJ program increased its 1RM half-squat strength more than the WL group (47.8 and 43.7%, respectively). Only the WL group improved in the SJ (9.5%). There were no significant changes in the control group. In conclusion, Olympic WL exercises seemed to produce broader performance improvements than VJ exercises in physically active subjects.
Tumor Suppressor Loss in Pituitary Tumors

The current model of human neoplasia invokes a number of potential genomic alterations that impact cellular phenotype and proliferative rates. In the majority of human tumor models, the transformation from normal cells to neoplastic lesion is a multistep process. This review offers a specific overview of the involvement of tumor suppressor genes (TSGs) in the pathogenesis of human pituitary adenomas. TSG genetic lesions, such as BRCA1 in breast cancer and p53 in Li‐Fraumeni Syndrome, have been identified in both sporadic and heritable human endocrine tumors. Familial neoplastic syndromes like multiple endocrine neoplasia type 1 (MEN1) that include pituitary tumor formation as part of a broad clinical spectrum of disease represent a unique opportunity to investigate the general mechanisms of tumorigenesis, and well as genes responsible for sporadic endocrine tumors. Similarly, homologous recombination knockout mice with selectively ablated candidate TSGs have also shed light on the molecular mechanisms of pituitary cell proliferation and tumor suppression. However, despite insights into pituitary tumorigenesis generated by heritable neoplasia syndromes and mouse knockout of critical TSGs that display a pituitary tumor phenotype, the molecular pathogenesis of human pituitary adenomas remains largely an enigma. Thus, the role of TSGs, if any, in sporadic pituitary adenoma formation has yet to be determined, despite our greater understanding of the molecular mechanisms underlying pituitary cell function and phenotype.
Periodic Paralysis as a New Phenotype of Resistance to Thyroid Hormone Syndrome in a Chinese Male Adult.

CONTEXT A majority of patients with resistance to thyroid hormone (RTH) are asymptomatic, whereas some patients show signs of hyperthyroidism, or hypothyroidism, or both. Thyrotoxic periodic paralysis is the most common form of acquired periodic paralysis. However, it has not been reported in a patient with RTH up to now. OBJECTIVE We evaluated a 36-year-old male patient from China with elevated serum free T4 and free T3 and inappropriately high TSH who presented with periodic paralysis. STUDY DESIGN Clinical, biochemical, and radiological assessments, as well as DNA sequencing, were performed. RESULTS The patient's laboratory tests revealed the following: TSH, 6.14 mIU/L (0.27-4.2 mIU/L); free T3, 12.85 pmol/L (2.8-7.1 pmol/L); free T4, 33.62 pmol/L (9.05-25.5 pmol/L); and serum SHBG, 19.4 nmol/L (18.3-54.1 nmol/L). No significant suppression of TSH was observed in the rapid TSH suppression test with somatostatin analogs. Compound muscle action potential after exercise of the patient was reduced by 58%. Sequencing of thyroid hormone receptor genes confirmed a C446S mutation in the THRβ gene. CONCLUSIONS This is the first report of periodic paralysis as a new phenotype of RTH syndrome.
Numerical analysis of ultra-wideband propagation for body-centric communication

This paper presents a study on body centric propagation based on ultra wideband technology using a compact and cost effective wearable antenna through simulations and validated by indoor environment measurements. The body worn antenna is placed on the human body model and different scenarios are considered such as off-body, body-to-body communication with and without the presence of partition made of concrete that will lead to variation in the propagation phenomenon. Fidelity factor results related to the received pulse shows that in the presence of the wall partition and human body, the average fidelity decreases by 4–5 % in comparison to no-obstacle scenario having high fidelity (0.97–0.99). Average fidelity in the presence of human body only is 0.96, thus leading to a reliable communication link in all scenarios.
Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling

We identified AATYK2 (Apoptosis‐Associated Tyrosine Kinase 2) through a database search as a kinase specifically expressed in the brain. After characterization, we renamed it BREK (Brain‐Enriched Kinase). Mouse BREK mRNA is expressed predominantly in brain, especially in olfactory bulb, olfactory tubercle, hippocampus, striatum, cerebellum, and cerebral cortex. Levels of expression and phosphorylation of BREK were high at 0–2 weeks after birth, suggesting that BREK is involved in neural development and functions during the early postnatal period. Phosphoamino acid analysis following in vitro kinase reaction revealed that BREK is a catalytically active, serine/threonine kinase. In PC12 cells, BREK was phosphorylated rapidly upon stimulation with nerve growth factor (NGF) in a protein kinase C‐dependent pathway. In differentiated PC12 cells, BREK was enriched in cell bodies and growth cones, and also present along neurites. Introduction of a kinase‐defective mutant of BREK into PC12 cells enhanced both ERK phosphorylation and neurite outgrowth in response to NGF, suggesting that BREK is a negative regulator of NGF‐induced neuronal differentiation. Thus, we conclude that BREK is a new member of the family of protein serine/threonine kinases and that it plays important roles in NGF‐TrkA signalling.
Long‐term forest resilience to climate change indicated by mortality, regeneration, and growth in semiarid southern Siberia

Several studies have documented that regional climate warming and the resulting increase in drought stress have triggered increased tree mortality in semiarid forests with unavoidable impacts on regional and global carbon sequestration. Although climate warming is projected to continue into the future, studies examining long‐term resilience of semiarid forests against climate change are limited. In this study, long‐term forest resilience was defined as the capacity of forest recruitment to compensate for losses from mortality. We observed an obvious change in long‐term forest resilience along a local aridity gradient by reconstructing tree growth trend and disturbance history and investigating postdisturbance regeneration in semiarid forests in southern Siberia. In our study, with increased severity of local aridity, forests became vulnerable to drought stress, and regeneration first accelerated and then ceased. Radial growth of trees during 1900–2012 was also relatively stable on the moderately arid site. Furthermore, we found that smaller forest patches always have relatively weaker resilience under the same climatic conditions. Our results imply a relatively higher resilience in arid timberline forest patches than in continuous forests; however, further climate warming and increased drought could possibly cause the disappearance of small forest patches around the arid tree line. This study sheds light on climate change adaptation and provides insight into managing vulnerable semiarid forests.
TATA-binding Protein-associated Factors Enhance the Recruitment of RNA Polymerase II by Transcriptional Activators*

Transcription factor (TF) IID, comprised of the TATA-binding protein (TBP) and TBP-associated factors (TAFs), is a general transcription factor required for RNA polymerase II (pol II) transcription on most eukaryotic genes. Recent findings that TAFs may not be globally required for activator-dependent transcription in vivo andin vitro and that both TAF-dependent and TAF-independent promoters are found in yeast suggest that transcriptional activation can occur through at least two different pathways, depending on the presence or absence of TAFs. Using order-of-addition and template challenge assays performed in a human cell-free transcription system reconstituted with recombinant general transcription factors (TFIIB, TBP, TFIIE, TFIIF), a recombinant general cofactor (PC4), and highly purified epitope-tagged multiprotein complexes (TFIID, TFIIH, pol II), we demonstrate that when TBP is used as the TATA-binding factor transcriptional activators such as Gal4-VP16 and human papillomavirus E2 mainly function by facilitating pol II entry to the promoter region. In contrast, when TFIID is used as the TATA-binding factor, promoter recognition by TFIID appears to be the rate-limiting step facilitated by transcriptional activators during preinitiation complex assembly. Using protein-protein pull-down and far-Western analyses, we further show that the presence of TAFs in TFIID facilitates the recruitment of pol II by transcriptional activators, thereby switching the rate-limiting step from pol II entry to promoter recognition. Our findings thus provide distinct molecular mechanisms for TAF-independent and TAF-dependent activation.
Framing responsibility: coverage of lung cancer among smokers and non‐smokers in Australian television news

Objective: To analyse news portrayals of lung cancer and associated inferences about responsibility in Australian television news.Methods: Analysis of television news reports, broadcast on Sydney's five free‐to‐air television channels between 2 May 2005 and 31 August 2009, for all statements pertaining to lung cancer.
Short-term fuzzy traffic flow prediction using self-organizing TSK-type fuzzy neural network

In this paper, an self-organizing TSK-type fuzzy neural network is proposed for predicting the short-term traffic flow. The proposed fuzzy neural network is adaptively organized from the collected short-term traffic flow data. The whole process is divided into two stage, i.e., structure identification and parameter learning. In structure identification, the mean shift clustering algorithm performs the whole traffic flow data set in order to generate the initial structure and mean firing strength method is used to prune the redundant fuzzy neurons. After the structure identification is finished, the chaotic parameter PSO is adopted to perform the parameter learning. Then the trained fuzzy neural network is employed the collected short- term traffic flow test set and the prediction result verifies that the self-organizing TSK-type fuzzy neural network has higher prediction accuracy than some traditional methods.
Molecular hepatoprotective effects of lipoic acid against carbon tetrachloride-induced liver fibrosis in rats

Background: Liver fibrosis is a noteworthy well-being issue that can prompt the progression of liver cirrhosis and hepatocellular carcinoma. Prominently, many antioxidants have been shown to have defensive impacts against liver fibrosis. Aim: Subsequently, in the present study, the viability of alpha-lipoic acid (α-LA) in ensuring against carbon tetrachloride (CCl4)-actuated liver fibrosis and the mechanism(s) involved in this defensive impact were considered in rats. Results: The present results uncovered that in the CCl4-treated group, the expression of antioxidant enzymes and matrix metalloproteinase-13 (MMP-13) messenger RNA (mRNA) was downregulated (p < 0.05), and the levels of lipid peroxide and nitric oxide were increased (p < 0.05) in the treated rat livers along with increased collagen deposition compared to that of the control group. Also, the gene expression levels of the proinflammatory factors interleukin-6 and tumor necrosis factor-alpha, nuclear factor-kappa B (NF-κB) p65, transforming growth factor-alpha, and inducible nitric oxide synthase (iNOS) were upregulated significantly (p < 0.05) in the CCl4 group. These negative impacts were all restrained by α-LA. Conclusions: These outcomes show that α-LA might be compelling at forestalling collagen deposition and hepatic oxidative stress as well as downregulating the expression of hepatic proinflammatory cytokines, iNOS, and NF-κB and upregulating MMP-13 expression.
HLA‐class II and class I genotypes among Japanese children with Type 1A diabetes and their families

Sugihara S, Ogata T, Kawamura T, Urakami T, Takemoto K, Kikuchi N, Takubo N, Tsubouchi K, Horikawa R, Kobayashi K, Kasahara Y, Kikuchi T, Koike A, Mochizuki T, Minamitani K, Takaya R, Mochizuki H, Nishii A, Yokota I, Kizaki Z, Mori T, Shimura N, Mukai T, Matsuura N, Fujisawa T, Ihara K, Kosaka K, Kizu R, Takahashi T, Matsuo S, Hanaki K, Igarashi Y, Sasaki G, Soneda S, Teno S, Kanzaki S, Saji H, Tokunaga K, Amemiya S, and The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT). HLA‐class II and class I genotypes among Japanese children with Type 1A diabetes and their families.
Development of the Dorsal Circumorbital Bones in the Leopard Gecko (Eublepharis macularius) and Its Bearing on the Homology of These Elements in the Gekkota

Five nominal elements comprise the circumorbital series of bones in gekkotans: prefrontal, postfrontal, postorbital, jugal, and lacrimal. Determination of the homology of two of these, the postfrontal and postorbital, has been particularly problematic. Two conflicting hypothesis exist relating to these: either the postorbital is lost and the postfrontal remains or they fuse during development to form a combined element, the postorbitofrontal. Such a combined element apparently occurs in at least some members of all lizard clades. There is, however, no direct developmental evidence that supports either theory. To overcome that, we investigate the sequence and pattern of ossification in the circumorbital region in a developmental series of the Leopard gecko. We posit that both the postfrontal and postorbital appear during development. Contrary to previous predictions they neither fuses to each other, nor do either degenerate. Instead, the postfrontal shifts anteriorly and fuses with the frontal to become indistinguishable from it by the time of hatching, and the postorbital persists as a robust independent element bounding the frontoparietal suture. These observations accord, in part, with both hypotheses of homology of these elements and result in the recognition of a new pattern, placing in doubt the existence of the composite postorbitofrontal. The phylogenetic implications of these findings may prove to be far reaching if similar and conserved patterns of development are encountered in other clades. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Systematic review and meta-analysis of psychomotor effects of mobile phone electromagnetic fields

Objectives Over the past 10 years there has been increasing concern about the possible behavioural effects of mobile phone use. This systematic review and meta-analysis focuses on studies published since 1999 on the human cognitive and performance effects of mobile phone-related electromagnetic fields (EMF). Methods PubMed, Biomed, Medline, Biological Sciences, PsychInfo, PsycARTICLES, Environmental Sciences and Pollution Management, Neurosciences Abstracts and Web of Science professional databases were searched and 24 studies selected for meta-analysis. Each study had to have at least one psychomotor measurement result as a main outcome. Data were analysed using standardised mean difference (SMD) as the effect size measure. Results Only three tasks (2-back, 3-back and simple reaction time (SRT)) displayed significant heterogeneity, but after studies with extreme SMD were excluded using sensitivity analysis, the statistical significance disappeared (χ2(7)=1.63, p=0.20; χ2(6)=1.00, p=0.32; χ2(10)=14.04, p=0.17, respectively). Following sensitivity analysis, the effect of sponsorship and publication bias were assessed. Meta-regression indicated a significant effect (b1/40.12, p<0.05) only for the 2-back task with mixed funding (industry and public/charity). Funnel plot inspection revealed a significant publication bias only for two cognitive tasks: SRT (Begg's rank correlation r=0.443; Egger's test b=−0.652) and the subtraction task (Egger's test b=−0.687). Conclusions Mobile phone-like EMF do not seem to induce cognitive and psychomotor effects. Nonetheless, the existence of sponsorship and publication biases should encourage WHO intervention to develop official research standards and guidelines. In addition, future research should address critical and neglected issues such as investigation of repeated, intensive and chronic exposures, especially in highly sensitive populations such as children.
Short‐term heat stress alters redox balance in porcine skeletal muscle

Heat stress contributes to higher morbidity and mortality in humans and animals and is an agricultural economic challenge because it reduces livestock productivity. Redox balance and associated mitochondrial responses appear to play a central role in heat stress‐induced skeletal muscle pathology. We have previously reported increased oxidative stress and mitochondrial content in oxidative muscle following 12 h of heat stress. The purposes of this investigation were to characterize heat stress‐induced oxidative stress and changes in mitochondrial content and biogenic signaling in oxidative skeletal muscle. Crossbred gilts were randomly assigned to either thermal neutral (21°C; n = 8, control group) or heat stress (37°C) conditions for 2 h (n = 8), 4 h (n = 8), or 6 h (n = 8). At the end, their respective environmental exposure, the red portion of the semitendinosus muscle (STR) was harvested. Heat stress increased concentration of malondialdehyde (MDA) following 2 and 4 h compared to thermal neutral and 6 h, which was similar to thermal neutral, and decreased linearly with time. Protein carbonyl content was not influenced by environment. Catalase activity was increased following 4 h of heat stress and superoxide dismutase activity was decreased following 6 h of heat stress compared to thermal neutral conditions. Heat stress‐mediated changes in antioxidant activity were independent of altered protein abundance or transcript expression. Mitochondrial content and mitochondrial biogenic signaling were similar between groups. These data demonstrate that heat stress caused a transient increase in oxidative stress that was countered by a compensatory change in catalase activity. These findings contribute to our growing understanding of the chronology of heat stress‐induced intracellular dysfunctions in skeletal muscle.
A Novel Intelligence Algorithm Based on the Social Group Optimization Behaviors

The collective intelligent behaviors of insects or animal groups in nature have maintained the survival of the species for thousands of years. In this paper, a novel swarm intelligence algorithm called the social group entropy optimization (SGEO) algorithm is proposed for solving optimization tasks. The proposed algorithm is based on the social group model, the status optimization model, and the entropy model, which are the main contributions of this paper. First, the social group model and the feedback mechanism between Leaders and Followers are developed to reduce the probability of local optimum. Second, the status optimization model is described to reveal the changing rule about the population behavior states, to support the conversion between different social behaviors during evolution, to promote the algorithm to optimize quickly, and to avoid local optimization. Third, the entropy model is introduced to analyze the entropy of social groups, the change rule of difference entropy, and to set the information entropy as behavior’s criterion of state optimization. In addition, the mathematical model of the SGEO is deduced from the group theory, matter dynamics, and the information entropy theory. The convergence and parallelism of it have been analyzed and verified theoretically. Moreover, to test the effectiveness of the SGEO, it is used to solve benchmark functions’ problems that are commonly considered within the literature of evolutionary algorithms. Experimental results are compared with those of three other state-of-the-art algorithms. The superior performance of the SGEO validates its effectiveness and efficiency for the optimization problems, especially for the high-dimension problems.
Stability of FDTD in curvilinear coordinates

A new approach suitable for determination of the maximal stable time step for the finite-difference time domain (FDTD) algorithm in curvilinear coordinates is presented. It is based on a modified variable separation method, applied to the set of difference equations of the FDTD algorithm. Investigation is carried out in spherical and cylindrical coordinates. A simple yet accurate enough approximative formula for cylindrical coordinates is presented. Applied to Cartesian coordinates, this approach yields the well-known Courrant condition.