Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of serum magnesium level with resistant hyperlipidemia in diabetic and hypertensive patients

Introduction: Both diabetes mellitus and hypertension are aspects of metabolic syndrome. Objectives: The aim of this study was to determine the relationship between serum magnesium level with resistant hyperlipidemia in a group of diabetic and hypertensive patients. Patients and Methods: The present cross-sectional study was carried out on 90 hypertensive and diabetic patients who referred to outpatient university clinic in Shahrekord (45 hypertensive and 45 diabetic patients). Included patients had high triglyceride levels despite 8 weeks of treatment with lipid-lowering agents. Results: There was an inverse significant relationship between serum magnesium and triglyceride levels in diabetic patients (P=0.002, r=-0.458), however, this correlation was not significant in hypertensive patients (P=0.754, r=0.048). Conclusion: This study showed, serum magnesium may affect triglycerides levels in diabetic patients, however, our finding requires further investigation with larger population.
Sepsis-induced Hyperleukocytosis in a Preterm

Hyperleukocytosis is defined as a white blood cell (WBC) count of ≥ 100,000/µL. Leukostasis refers to symptomatic hyperleukocytosis and is considered a medical emergency. In pediatric practice, hyperleukocytosis is most commonly described in leukemia and other myeloproliferative disorder, but other etiologies, such as infection, are less commonly mentioned. In this case report, a one-day-old, preterm, male baby (26 weeks of gestation) was referred for preterm care. A sepsis-induced leukemoid reaction hyperleukocytosis diagnosis was presumed, and he was successfully treated with an empirical antibiotic with a gradual improvement in WBC counts.
The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study

Introduction Delirium is associated with a wide range of adverse patient safety outcomes. We sought to identify if trends in healthcare complexity were associated with changes in reported delirium in adult medical patients in the general hospital over the last four decades. Methods We used identical criteria to a previous systematic review, including studies using DSM and ICD-10 criteria for delirium diagnosis. Random effects meta-analysis pooled estimates across studies, meta-regression estimated temporal changes, funnel plots assessed publication bias. Results Overall delirium occurrence was 23% (95% CI 19%-26%) (33 studies). There was no change between 1980-2019, nor was case-mix (average age of sample, proportion with dementia) different. There was evidence of increasing publication bias over time. Discussion The incidence and prevalence of delirium in hospitals appears to be stable, though publication bias may mask true changes. Nonetheless, delirium remains a challenging and urgent priority for clinical diagnosis and care pathways.
Predictors of Condom Use Among People Living with HIV in Karaj: A Cross-Sectional Study

Background: Sexual transmission of HIV/AIDS is a major route for infection and the most effective strategy to control this infection is condom use. Objectives: This study aimed to assess the predictors of condom use among HIV positive patients. Methods: This cross sectional study was a descriptive-analytical study. A total of 121 HIV positive individuals, which included 57 women and 64 men were recruited during five months from a Behavioral Diseases Counseling Center in Karaj. Data were collected by questionnaires including demographic characteristics, drug abuse history, sexual history, depression, and social support. Social support and depression were evaluated by MOS questinnaire and Beck II, respectively.Data analysis was done by SPSS version 19. Results: The mean age of the participants was 36.6 ± 8 years. About 39% of HIV positive patients in this study used a condom during their last sexual encounter; however, consistent use of condom occurred in 28.1% cases in the past three months. Multivariate regression showed that the number of sexual partners’ (β = 0.16), (P < 0.01) age (β = -0.23), (P < 0.05) number of children (β = 0.21), (P < 0.05) and social support (β = 0.58), (P < 0.001) were predictors of condom use. Conclusions: Considering the low rate of condom use among HIV-positive patients, it is essential to provide counseling services and gender sensitive interventions to promote safer sex behavior in this context. As social support is a critical variable to predict condom use, it is suggested to be considered to develop effective prevention programs for people living with HIV.
CORRELATION OF LIPID PROFILE & BODY MASS INDEX (BMI) OF PATIENTS AT A TERTIARY CARE HOSPITAL: A CROSS SECTIONAL STUDY

Background: Sedentary daily life have an impact on the prevalence and incidence of metabolic syndrome disorder and results in development of type 2 diabetes mellitus, Dyslipidemia and metabolic disorders that aggravate the risk in the development of cardiovascular diseases (CVD). Methods: In our study Data of 92 males and 112 females, from the age group of 25 to 55 years were selected from December 2018 to July 2019 in a cross sectional manner. Blood sample (3 ml) was collected from each subject. Serum was separated by centrifuging blood at 3000 rpm for 10 min and analyzed for lipid profile by Siemens Dimension RXL max, wet chemistry analyzer. Body mass index (BMI) was calculated as weight in kilograms divided by the square of height in meters. Results: In our hospital based study we estimated the lipid profile in individuals categorized into two groups. (Group 1 BMI <25) and (Group 2 BMI ≥25), we found the values of Triglycerides, LDL and VLDL in Group 1 are lower as compared to Group 2 values for same analytes. Conclusion: Our study found positive correlation between lipid profile and obesity. Results of this cross sectional study again prove that, Obesity predisposes individuals to metabolic syndrome associated ailments. Keywords: BMI, Lipid Profile, Metabolic Syndrome, Obesity, Dyslipidemia
The Effect of High Intensity Interval Training Versus Steady State Aerobic Training on Skin Microvascular Reactivity in Moderately Active Young Adults: A Pilot Study

A sedentary lifestyle is associated with endothelial dysfunction, leading to vascular pathology and impaired microvascular reactivity (MVR). Enhanced endothelial functioning has been seen in aerobically trained individuals. The purpose of this study was to determine if there was a differential training response of skin MVR in response to high intensity aerobic interval training (HIAIT) as compared to steady state aerobic training (SSAT). The study involved 16 moderately active male students (age: 20.93 ± 5.05 yrs). They were randomly assigned to one of three groups; HIAIT, SSAT, and control group (CG). Baseline testing was performed to determine the VO2max, lactate threshold, blood pressure, body composition and a post-occlusive reactive hyperemia response (PORH) test was used to assess microvascular reactivity on the right palmer forearm using a moorVMS-Laser Doppler Flowmetry (LDF) These parameters were reassessed after three weeks (mid-point) and six-weeks (post intervention) weeks. Statistical significance was set at p≤0.05. There were no significant interactions between the variables measured in the three groups over time. There was a positive linear relationship in the SSAT group for PORHmax/time to peak (Tp) at baseline (r = 0.998, p = 0.039), midpoint (r = 0.992, p = 0.083), and the post intervention (r = 0.987, p = 0.103). Training in the SSAT group had improved PORHpeak at midpoint and post intervention time points (r = 0.999, p = 0.22; r = 1, p = 0.006; r = 1, p = 0.011). Training in either the HIAIT or the SSAT group had no significant effect on skin MVR in moderately active young adults. SSAT did display a positive linear relationship with PORHmax/Tp, and PORHpeak, which are variables influencing skin MVR.
Beneficial effects of Japanese sake yeast supplement on biochemical, antioxidant, and anti-inflammatory factors in streptozotocin-induced diabetic rats

Background Using chemical agents in the treatment of diabetes mellitus type 2 may have some limitations due to frequent side effects. Some novel and natural agents may be promising alternatives in this case. This study was designed to evaluate the effects of oral Japanese sake yeast supplement, as a novel agent, on biochemical antioxidant and anti-inflammatory parameters in experimentally induced diabetic rats. Materials and methods After inducing diabetes (55 mg/kg intraperitoneal injection of streptozotocin), 120 male adult Wistar rats were randomly divided into 5 groups and each group received 0 (control), 15, 30, or 45 mg/kg of sake yeast or was considered a nondiabetic control. Then, the serum levels of tumor necrosis factor-α, IL-6, C-reactive protein, malondialdehyde, glutathione, total antioxidant status, glucose, cholesterol, triglycerides, and insulin were evaluated and compared to baseline measures. Results The results showed that oral administration of sake yeast at different concentrations reduced levels of malondialdehyde, glucose, cholesterol, and triglycerides and increased levels of insulin, glutathione, and total antioxidants (P<0.05). The best responses were observed in the nondiabetic control group. Conclusion Sake yeast supplement may be useful as a novel agent in the treatment of diabetes.
Human Reproductive Health in Relation to Thyroid Alterations

Background: Thyroid alterations have adverse effects on other health systems in the body, and reproductive system is one of the most affected organs. Here, we perform a comprehensive analysis on the effects of different thyroid abnormalities on sexual and reproductive-related hormones in both men and women in different age groups. Method: A comprehensive analysis was performed on 15,043 subjects within the reproductive age (15 - 49 years). They were tested for thyroid markers (TSH, FT4, anti-TPO, anti-Tg) and 13 reproductive hormones in Vibrant America Clinical Laboratory between March 2016 to July 2018. The alterations of each reproductive hormone in hypothyroidism, hyperthyroidism, anti-TPO+ anti-Tg+ groups were evaluated. Results: A total of 10,626 women was tested. Women with hypothyroidism had elevated cortisol and low SHBG and DHEA-S. Women with hyperthyroidism showed elevated total testosterone and SHBG. Women seropositive for anti-TPO had elevated total testosterone and low cortisol. Women seropositive for anti-Tg had low parathyroid hormones. Similarly, a total of 4417 men was tested. Men with hypothyroidism had low IGF-I. Similarly, men with hyperthyroidism had low DHEA-S, but elevated estradiol, FSH, LH and prolactin. Men seropositive for anti-TPO had elevated SHBG and low progesterone. Men seropositive for anti-Tg had elevated progesterone. The reproductive and related hormone levels of age group 36 - 49 showed the most variations. Conclusion: Our results clearly show that individuals with different thyroid alterations have different effects on reproductive health, especially in the age group 36 - 49. Hence, routine testing and follow-up checkups on reproductive system would be beneficial for individuals in the age group 36 - 49 with thyroid disorders.
Antiphospholipid Syndrome in Pregnancy

Antiphospholipid Syndrome (APS) is associated in pregnancy with repeat abortions and fetal loss; other frequently reported complications are preeclampsia and placental insufficiency. The pathogenesis of fetal losses in the APS is due to the thrombophilic effect caused by the presence of antibodies against phospholipids and to other mechanisms that include direct effects on the trophoblast and inflammatory phenomena. Accurate laboratory identification is a fundamental pillar in differential diagnosis of other obstetric pathologies. The combination of a very detailed and close follow up in conjunction with an established treatment will result in a successful pregnancy.
Association between polymorphisms in EGFR and tumor response during cetuximab and oxaliplatin-based combination therapy in metastatic colorectal cancer: Analysis of data from two clinical trials

Predicting tumor response prior to starting anti-epidermal growth factor receptor (EGFR) antibody therapy would benefit patients with advanced/metastatic colorectal cancer (mCRC). The present study investigated the association between efficacy of cetuximab treatment and gene polymorphisms of fragment C γ receptor (FcγR) 2A, FcγR3A and EGFR in patients with extended RAS/BRAF wild-type mCRC. Clinical data and specimens were obtained from 90 patients who participated in either of two clinical studies evaluating the first-line, cetuximab plus oxaliplatin-based treatment. It was hypothesized that polymorphisms H/H of FcγR2A, V/V of FcγR3A, K/K of EGFR and <36 CA repeats in the EGFR gene may be associated with a favorable tumor response. Multivariate analysis demonstrated that patients with the H/H polymorphism tended to have an improved tumor response compared with the non-H/H population, although the result was not significant [odds ratio, 2.25; 95% confidence interval (CI), 0.89–5.66; P=0.09]. Univariate analysis revealed increased tumor shrinkage in patients with the K/K polymorphism of EGFR compared with the other polymorphisms (mean ± standard deviation, −55.3±28.4 vs. −39.6±40.8%; P=0.04). Subsequent multivariate analysis confirmed that the K/K polymorphism of EGFR predicted greater tumor shrinkage (multiple linear regression analysis estimate, −19.3; 95% CI, −35.5 to 3.0; P=0.02), with the tendency toward a preferable response in patients with <36 CA EGFR gene repeats (estimate, −16.9; 95% CI; −34.4 to 0.6; P=0.06). However, other polymorphisms and clinical variables did not predict tumor shrinkage. In conclusion, the present study demonstrated that polymorphisms of EGFR, FcγR2A and FcγR3A may differentiate the patients that obtain the maximum benefit from cetuximab treatment.
IN VITRO ANTIFUNGAL DRUG SUSCEPTIBILITY OF DERMATOPHYTES ISOLATED FROM PATIENTS IN AL-MEDINA, SAUDI ARABIA -

: The antifungal activities of seven commercially available antifungal drugs (fluconazole, itraconazole, ketoconazole, miconazole, clotrimazole, terbinafine and griseofulvin) were evaluated by broth microdilution method as proposed by the Clinical and Laboratory Standards Institute (CLSI), against 70 dermatophyte isolates from hair, skin and nail specimens of patients with cutenous mycosis in Al-Medina city, Saudi Arabia. In this study, the microtiter plates were incubated at 28ºC allowing a reading of the minimal inhibitory concentration (MIC) after four to five days of incubation. In vitro antifungal drug susceptibility studies showed that most of the dermatophytes had uniform patterns of susceptibility towards the tested antifungal agents. Of these antifungal agents, the best results in terms of sensitivity were found with terbinafine and clotrimazole, while the anti fungal activity of fluconazole and griseofulvin was found to be weak, particularly against strains of Trichophyton verrucosum . Although less effective than terbinafine and clotrimazole still the remaining four antifungal agents (itraconazole, ketoconazole and miconazole) also yielded satisfactory results.
F-FDG Uptake Is Predictive of Poor Survival After Surgery for Large-CellNeuroendocrine-Carcinomas of The Lung: A Bicentric Analysis

Introduction: Large cell neuroendocrine carcinoma (LCNEC) represents a relatively rare and poorly studied entity whose management is not clearly established. The aim of this study was to explore the relationship between preoperative 18F-FDG-PET results, pathological features and long-term survival in a large surgical cohort of LCNEC. Methods: From 06/08 to 06/17, the clinical, radiometabolic, pathological and surgical aspects of 121 LCNEC-patients surgically treated in 2 tertiary centers were retrieved. A Cox regression model was used to identify predictors of survival and Kaplan-Meier method to summarize overall survivals. Results: Mean age and male/female ratio were 63.4±8.3 and 3:1, respectively. The main clinical, radiometabolic and surgical characteristics are reported in Tab.1. Most patients were active/former smokers and presented symptoms at diagnosis. 18FDG-PET/Scan was performed in 65 patients (53.7%) with a mean SUVmax of 10.1 (SD±4.6). Higher SUVmax values (SUVmax >10) were detected in tumors with larger size (p=0.004), advanced p-Stages (p=0.019), presenting necrosis (p=0.077) and with positive staining for CD56 (p=0.025) and TTF-1 (0.063). After surgery (R0 in 91% of cases), 52 (43%) patients had pStage-I while about 35% of patients presented with N1-2 disease. Median, 3-yrs and 5-yrs overall survival was 40 months, 52.2% and 44.6%, respectively. At univariate analysis, the survival was significantly influenced by SUVmax values (p=0.009) and by the presence of vascular invasion at pathological examination (p=0.024). Multivariate analysis showed as the FDG-SUVmax was the only independent variable affecting long-term survival (HR:2.86;C.E.: 1.09-7.47;p=0.032). Conclusions: Patients underwent surgical resection for LCNEC of the lung experienced a poor prognosis (5-yrs survival = 44.6% in this study). High-level FDG accumulation (SUVmax >10) correlates with pathological features and results to be independently predictive of poor survival after surgery. This parameter should be taking into account when planning the best strategy of care.
Endodontic Tendencies in a Very-Low-Income Population Area of Northeastern Brazil

Aim To gather information regarding endodontic treatment protocols and continuing education attendance of dentists in some cities located in Northeastern Brazil (Sergipe and Bahia States), a region that comprises a very-low-income population. Methods A questionnaire containing different questions (e.g., routine treatment protocols, the use of new technologies, time required to conclude the treatment, and attendance in an endodontic continuing education) was distributed to 250 dentists. The collected data were analyzed through descriptive statistics and Poisson regression (p < 0.05). Results A total of 199 dentists practicing endodontic treatment in the cities of Aracaju (n = 58), Salvador (n = 83), and towns of Estância (n = 8), Itabaiana (n = 16), Itabaianinha (n = 5), Lagarto (n = 10), Ribeirópolis (n = 3), Simão Dias (n = 6), and Tobias Barreto (n = 10) participated in this research. Most of the respondents have concluded their graduation in Dentistry in less than 10 years (62.3%), with nearly 75.4% of the sample having attended postgraduation education in the field. Regarding treatment protocols, the frequency for using rotary/reciprocating systems and for always using rubber dam isolation during root canal treatment (RCT) was 78% and 62%, respectively, which was also more prevalent among dentists who attended a continuous education program (p < 0.05). Lastly, the professionals who attended (p < 0.05) to a continuous education program in Endodontics were more frequently associated to performing incisors and molars RCT in one clinical appointment (p < 0.05). Conclusions The results of this survey indicated that even in an area where most of the population has low-income conditions, the professionals are seeking for knowledge by attending to postgraduation programs, following the new tendencies in Endodontics with most of the professionals having employed technological resources.
The demographic and clinicopathological features of salivary gland tumors in Turkey

Aim: Salivary gland tumors (SGTs) are rare neoplasms thus, the local records are valuable to obtain the epidemiological overview. This study aimed to determine the demographic and clinicopathological features of SGTs in our clinic and compare the findings with the studies from Turkey and all over the world. Material and methods: The data of 185 patients who underwent surgery for SGT in The Department of Otorhinolaryngology-Head and Neck Surgery of a tertiary referral center between 2012 and 2017 were studied retrospectively. The demographic and clinicopathological features of the patients were recorded. Results: Among all patients with primary and secondary SGTs, the median age was 53 years, 54.6% of the patients were men. Patients with primary tumor constituted 96.8% of all cases. Malignancy rate was 14. Parotid gland was the most common location (90%). Nearly half of all primary tumors were diagnosed as pleomorphic adenoma (n=84, 46.9%). Mucoepidermoid carcinoma was the most common malign neoplasm of the parotid gland. There were only six patients (3.2%) that had secondary SGT. Conclusion: Pleomorphic adenoma and mucoepidermoid carcinoma were the most common benign and malign pathologies, respectively. The lowest malignancy rate and the highest rate of warthin tumor of the existing literature were the most conspicuous findings of our study. Although the frequency of the secondary SGTs is low, the possibility of metastasis should be considered especially for the patients above 65 years of age.
Diagnostic utility of semen analysis in infertile couples: a prospective study

Background: Infertility is defined as a failure to conceive after at least 12 months of unprotected intercourse. It is broadly established that 40% cases of infertility has male factor. Semen analyses is an imperative diagnostic tool in the valuation of the male partners of infertile couples.Methods: We carried out a prospective study wherein semen analyses of the male partners of infertile couples presented to Department of Pathology, Government Medical College and Associate Hospital, Jammu was done. A total of 300 cases were studied and comparison of each abnormality and combined defects were subjected to incidence distribution.Results: We analysed 300 samples in this study. Mean age of the men was 32.5 years. Duration of infertility in (200; 66.6%) was seen in men married for less than 5 years, (84; 28%) between 5-10 years of married life and there were (16; 5.3%) with more than 10 years of infertility period after marriage. Addiction to alcohol made the majority in our study (187; 62.3%), followed by tobacco chewing and addiction to both tobacco chewing and alcohol consumption (89; 29.6%) and (24; 8%), respectively, men were amongst those with abnormal seminograms.Conclusions: Male infertility is an alarming global health issue. Males contribute towards infertility in couples significantly and further study and assessment is required to accurately predict the importance of this.
The Effect of Implant Conformity on Muscle Force Requirements in the Implanted Knee

vi TABLE OF CONTENTS . vii LIST OF TABLES . ix LIST OF FIGURES . x LIST OF ABBREVIATIONS . xii CHAPTER ONE : INTRODUCTION . 1 1.1 A brief overview of total knee replacement procedure and loss of stability . 1 Muscle Activation Strategies in The Unstable Knee . 4 Methods of Characterizing Stability in The Natural and Implanted Knee . 5 Implant Conformity and The Effect On Knee Stability . 12 1.2 Motivation . 13 1.3 Research goals . 14 CHAPTER TWO : MANUSCRIPT “THE EFFECT OF IMPLANT CONFORMITY ON MUSCLE FORCE REQUIREMENTS IN THE IMPLANTED KNEE" . 15 2.