Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunopathology and Infectious Disease Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals

Viral attachment to the host cell is critical for tissue and species specificity of virus infections. Recently, pattern of viral attachment (PVA) in human respiratory tract was determined for highly pathogenic avian influenza virus of subtype H5N1. However, PVA of human influenza viruses and other avian influenza viruses in either humans or experimental animals is unknown. Therefore, we compared PVA of two human influenza viruses (H1N1 and H3N2) and two low pathogenic avian influenza viruses (H5N9 and H6N1) with that of H5N1 virus in respiratory tract tissues of humans, mice, ferrets, cynomolgus macaques, cats, and pigs by virus histochemistry. We found that human influenza viruses attached more strongly to human trachea and bronchi than H5N1 virus and attached to different cell types than H5N1 virus. These differences correspond to primary diagnoses of tracheobronchitis for human influenza viruses and diffuse alveolar damage for H5N1 virus. The PVA of low pathogenic avian influenza viruses in human respiratory tract resembled that of H5N1 virus, demonstrating that other properties determine its pathogenicity for humans. The PVA in human respiratory tract most closely mirrored that in ferrets and pigs for human influenza viruses and that in ferrets, pigs, and cats for avian influenza viruses. (Am J Pathol 2007, 171:1215–1223; DOI: 10.2353/ajpath.2007.070248)
How do general practitioners put preventive care recommendations into practice? A cross-sectional study in Switzerland and France

Objectives We previously identified that general practitioners (GPs) in French-speaking regions of Europe had a variable uptake of common preventive recommendations. In this study, we describe GPs’ reports of how they put different preventive recommendations into practice. Design, setting and participants Cross-sectional study conducted in 2015 in Switzerland and France. 3400 randomly selected GPs were asked to complete a postal (n=1100) or online (n=2300) questionnaire. GPs who exclusively practiced complementary and alternative medicine were not eligible for the study. 764 GPs (response rate: postal 47%, online 11%) returned the questionnaire (428 in Switzerland and 336 in France). Main outcome measures We investigated how the GPs performed five preventive practices (screening for dyslipidaemia, colorectal and prostate cancer, identification of hazardous alcohol consumption and brief intervention), examining which age group they selected, the screening frequency, the test they used, whether they favoured shared decision for prostate cancer screening and their definition of hazardous alcohol use. Results A large variability was observed in the way in which GPs provide these practices. 41% reported screening yearly for cholesterol, starting and stopping at variable ages. 82% did not use any test to identify hazardous drinking. The most common responses for defining hazardous drinking were, for men, ≥21 drinks/week (24%) and ≥4 drinks/occasion for binge drinking (20%), and for women, ≥14 drinks/week (28%) and ≥3 drinks/occasion (21%). Screening for colorectal cancer, mainly with colonoscopy in Switzerland (86%) and stool-based tests in France (93%), was provided every 10 years in Switzerland (65%) and 2 years in France (91%) to patients between 50 years (87%) and 75 years (67%). Prostate cancer screening, usually with shared decision (82%), was provided yearly (62%) to patients between 50 years (74%) and 75–80 years (32%–34%). Conclusions The large diversity in the way these practices are provided needs to be addressed, as it could be related to some misunderstandingof the current guidelines, to barriers for guideline uptake or, more likely, to the absence of agreement between the various recommendations.
Success Rate and Utility of Ultrasound-guided Synovial Biopsies in Clinical Practice

Objective. The utility of synovial biopsy in increasing our understanding of the pathogenesis of inflammatory arthropathies, as well as in evaluating treatments, is well established. Ultrasound (US) allows synovial assessment and therefore assists in biopsying synovial tissue in a safe and well-tolerated manner. This study’s objectives were to (1) determine the rate of success in retrieving synovial tissue using US guidance, (2) describe the indications for US-guided synovial biopsies in the clinical setting, (3) determine how frequently the synovial biopsy can lead to a clear diagnosis, and (4) assess the quality of the synovial tissue obtained using this technique. Methods. Synovial biopsies of small and large joints were performed under US guidance between February 2007 and December 2014 using a semiautomatic core biopsy needle. The biopsy procedure was considered successful if synovial tissue was found at histological examination. Results. Seventy-four patients with undifferentiated arthritis underwent 76 synovial biopsies. The success rate in retrieving synovial tissue was 81.6% (62/76). One patient taking acetyl salicylic acid at 75 mg at the time of the biopsy presented with hemarthrosis 48 h after the procedure, which resolved following simple arthrocentesis. A definitive diagnosis was achieved in 16% of the patients where synovial tissue was sampled successfully. Conclusion. US-guided synovial biopsies in clinical practice can be performed safely on patients with undifferentiated arthritis and with heterogeneous presentations. The rate of success in acquiring synovial tissue is high. The procedure usually retrieves quality tissue and leads to a definite diagnosis in a significant minority of patients.
Ranking, relevance judgment, and precision of information retrieval on children's queries: Evaluation of Google, Yahoo!, Bing, Yahoo! Kids, and ask Kids

This study employed benchmarking and intellectual relevance judgment in evaluating Google, Yahoo! , Bing, Yahoo! Kids, and Ask Kids on 30 queries that children formulated to find information for specific tasks. Retrieved hits on given queries were benchmarked to Google's and Yahoo! Kids' top-five ranked hits retrieved. Relevancy of hits was judged on a graded scale; precision was calculated using the precision-at-ten metric (P@10). Yahoo! and Bing produced a similar percentage in hit overlap with Google (nearly 30%), but differed in the ranking of hits. Ask Kids retrieved 11% in hit overlap with Google versus 3% by Yahoo! Kids. The engines retrieved 26 hits across query clusters that overlapped with Yahoo! Kids' top-five ranked hits. Precision (P) that the engines produced across the queries was P = 0.48 for relevant hits, and P = 0.28 for partially relevant hits. Precision by Ask Kids was P = 0.44 for relevant hits versus P = 0.21 by Yahoo! Kids. Bing produced the highest total precision (TP) of relevant hits (TP = 0.86) across the queries, and Yahoo! Kids yielded the lowest (TP = 0.47). Average precision (AP) of relevant hits was AP = 0.56 by leading engines versus AP = 0.29 by small engines. In contrast, average precision of partially relevant hits was AP = 0.83 by small engines versus AP = 0.33 by leading engines. Average precision of relevant hits across the engines was highest on two-word queries and lowest on one-word queries. Google performed best on natural language queries; Bing did the same (P = 0.69) on two-word queries. The findings have implications for search engine ranking algorithms, relevance theory, search engine design, research design, and information literacy. © 2012 Wiley Periodicals, Inc.
The pharmacokinetics of a single dose of artemisinin in patients with uncomplicated falciparum malaria.

The pharmacokinetics of artemisinin was studied in 11 Vietnamese patients with uncomplicated falciparum malaria after a single 500 mg oral dose. Curative treatment with mefloquine (15 mg/kg) was provided 24 hr after the artemisinin dose. Artemisinin concentrations were measured by high-performance liquid chromatography with electrochemical detection. The following pharmacokinetic results were found (all mean +/- SD); calculated volume of distribution/bioavailability = 22.8 +/- 16.6 L.kg-1, mean absorption time = 1.16 +/- 0.92 hr, calculated maximum concentration = 364 +/- 250 micrograms.L-1 occurring at 2.88 +/- 1.71 hr after drug intake, and an elimination half-life of 2.72 +/- 1.76 hr. Bioavailability was low. These results do not differ from results in healthy subjects. Parasites disappeared rapidly, with a mean parasite clearance time of 36 hr. No relationship was found between pharmacokinetics and the parasite elimination rate. Tolerance to the single dose of artemisinin was good. No adverse effects were detected. In conclusion, pharmacokinetics of a single dose of artemisinin for uncomplicated falciparum malaria is not different from findings in healthy subjects. A single dose of 500 mg of artemisinin is effective in reducing parasitemia in nonsevere lalciparum malaria and is well-tolerated.
Sustainability in small tourist businesses: the link between initiatives and performance

This study explores the combined effects of adopting sustainable practices on small tourism companies’ performance. The existing literature provides insufficient data on sustainable behaviour because most studies on environmental practices focus on larger companies in the tourism sector, and a gap exists in social practices. This study is based on a survey of 374 restaurant managers. It uses structural equation modelling to study direct links between three dimensions – quality, environmental practices and social practices – and financial performance and market success factors. Significant differences with earlier studies are found. This study suggests that proactive sustainable practices can benefit small service companies by improving competitiveness even in difficult times. Practical implications are discussed in relation to sustainable practices.
Belowground plant biomass allocation in tundra ecosystems and its relationship with temperature

Climate warming is known to increase the aboveground productivity of tundra ecosystems. Recently, belowground biomass is receiving more attention, but the effects of climate warming on belowground productivity remain unclear. Enhanced understanding of the belowground component of the tundra is important in the context of climate warming, since most carbon is sequestered belowground in these ecosystems. In this study we synthesized published tundra belowground biomass data from 36 field studies spanning a mean annual temperature (MAT) gradient from −20 °C to 0 °C across the tundra biome, and determined the relationships between different plant biomass pools and MAT. Our results show that the plant community biomass–temperature relationships are significantly different between above and belowground. Aboveground biomass clearly increased with MAT, whereas total belowground biomass and fine root biomass did not show a significant increase over the broad MAT gradient. Our results suggest that biomass allocation of tundra vegetation shifts towards aboveground in warmer conditions, which could impact on the carbon cycling in tundra ecosystems through altered litter input and distribution in the soil, as well as possible changes in root turnover.
HMGA2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating the TGF-β/Smad2 signaling pathway

High-mobility group AT-hook 2 (HMGA2), a member of the high mobility group family, has been reported to correlate with cancer progression. However, there is no report concerning the correlation between HMGA2 and metastasis in renal cell carcinoma. In the present study, we found that HMGA2 was highly expressed in five renal cell carcinoma cell lines compared with that in the normal renal tubular epithelial HK2 cell line. Additionally, HMGA2 facilitated cell migration and invasion of renal cell carcinoma cells, as evidenced by wound healing and Transwell assays. Subsequently, our results revealed that the E-cadherin level was upregulated, while N-cadherin, Twist1 and Twist2 expression were downregulated in HMGA2-depleted ACHN cells. In contrast, overexpression of HMGA2 in 786-O cells enhanced epithelial-mesenchymal transition (EMT). In addition, analysis of the database Cancer Browser further validated the positive correlation between HGMA2 and Twist1 or Twist2 in renal cell carcinoma. Meanwhile, Kaplan-Meier analysis indicated that low HMGA2 expression was closely associated with an increased overall survival in renal cell carcinoma patients. To confirm the underlying mechanism of HMGA2-regulated EMT, our results revealed that silencing of HMGA2 downregulated the mRNA and protein levels of TGF-β and Smad2, while HMGA2 overexpression had the opposite effect. Furthermore, TGF-β overexpression could partially reverse the anti-metastatic effect and mesenchymal-epithelial transition (MET) by HMGA2 loss, while TGF-β deficiency impeded the pro-metastatic phenotype and high expression of EMT markers induced by HMGA2 overexpression. In summary, our results demonstrated that HMGA2 facilitated a metastatic phenotype and the EMT process in renal cell carcinoma cells in vitro through a TGF-β-dependent pathway. In addition, these data strongly suggest that HGMA2 may serve as a potential therapeutic target and prognostic biomarker against renal cell carcinoma in the future.
Long-Term Results of the Plugging Method with Regard to the Prevention of a Postoperative Inguinal Hernia After Robot-Assisted Laparoscopic Prostatectomy: A Retrospective Study.

PURPOSE We previously identified that the existence of a patent processus vaginalis (PPV) is an important risk factor for a postoperative inguinal hernia (IH) in patients undergoing robot-assisted laparoscopic prostatectomy (RALP), and we introduced a novel plugging method to prevent IH development. The present study aimed to analyze the long-term outcomes of this plugging method. PATIENTS AND METHODS A total of 1026 groins were reviewed between May 2007 and March 2016. The plugging method was prospectively applied to patients with a PPV since May 2011. For patients with inguinal discomfort, ultrasonography was used to evaluate IH development. RESULTS An IH developed postoperatively in 35 (3.4%) groins at a median time of 22.0 months during a median follow-up of 41 months. Of the 291 groins with a PPV, plugging was performed in 167 (57.4%) groins. The presence of a PPV without the preventive procedure was a major risk factor for a postoperative IH. No prognostic difference in IH development was noted between the group without a PPV and the group with a PPV that underwent the plugging method. Body mass index (≥23.0 kg/m2) and presence of a PPV were independent predictors for IH development in groins that did not undergo the plugging method. For groins that underwent the plugging method, previous operation history was an independent predictor. CONCLUSIONS The plugging method is effective for long-term prevention of postoperative IHs in patients undergoing RALP.
Risk and Loss Aversion, Price Uncertainty and the Implications for Consumer Search

Do the choices of consumers who search for a product's best price exhibit risk neutral, risk averse or loss averse risk attitudes? We study how in a problem of sequential search with costless recall the relation between a consumer's willingness to pay for continued search and the level of price uncertainty depends on her risk preferences. Independent of the current best price, an increase in price uncertainty encourages continued search when consumers are risk neutral. However, we prove that theory predicts an inversion when consumers are either risk or loss averse. In those cases, an increase in price uncertainty only increases the consumer's willingness to pay (WTP) for continued search if the current best price is sufficiently low. We subsequently use this observation in an empirical test to identify between different risk preferences in a stylized problem of sequential search. In line with the inversion, we find that a reduction in price uncertainty decreases the WTP for continued search when the current best price is low but increases the WTP when it is high. While at odds with the assumption of risk neutrality, this finding is consistent with models of consumer risk and/or loss aversion. Moreover, the model parameters of risk and loss aversion that lead to the best empirical fit have values similar to those estimated for other decision domains.
Therapeutic options to target angiogenesis in human malignancies

The critical role of angiogenesis in tumour growth and metastasis is now well established in the literature. Growing tumours stimulate neovascularisation through the secretion of pro-angiogenic growth factors, in particular, basic fibroblast growth factor and VEGF. Several lines of evidence have implicated VEGF in tumourigenesis, and understanding the role of VEGF in tumour angiogenesis has facilitated the development of novel targeting agents that specifically interfere with angiogenesis. Different approaches to disrupting tumour-induced angiogenesis encompass tyrosine kinase inhibitor, monoclonal antibodies, small-molecule inhibitors and transcription inhibitors. However, monoclonal antibody and tyrosine kinase inhibitors are the most advanced drug classes currently being investigated in clinical trials. So far, three anti-VEGF inhibitors, bevacizumab, sunitinib and sorafenib, have been approved for the treatment of solid human malignancies including colorectal cancer, gastrointestinal stromal tumours and renal cell carcinoma. Other antiangiogenic drugs are being investigated in various types of cancer. This review summarises the current literature on the use of these agents to interfere with VEGF, VEGF receptor, the matrix breakdown or other mechanisms involved in angiogenesis.
The effectiveness of board of directors’ characteristics in mandatory disclosure compliance

The purpose of this paper is to investigate the relationship between the characteristics of the board of directors and mandatory disclosure compliance (measured by International Financial Reporting Standards requirements) in firms listed on the Kuwait Stock Exchange (KSE) in 2010. ,Several characteristics are used to assess the effectiveness of the board of directors: number of members, gender diversity, CEO duality, multiple directorships, the proportion of family members on the board and the presence of a member of the ruling family of Kuwait. Mandatory disclosure compliance is measured using a self-constructed, item-based index. A regression model tested the paper’s hypotheses. ,After controlling for firm-specific characteristics, it was found that board size, gender diversity and multiple directorships were positively correlated with compliance, while CEO duality and the proportion of family members on the board were negatively correlated with compliance. ,Potential limitations stem from both the nature of the sample and the dataset. The small sample reflects the size of the KSE and the limited timeframe (a one-year period). Nevertheless, this paper provides some interesting insights. A longitudinal study would provide more comprehensive insights into the relationship between the characteristics of the board of directors and mandatory disclosure compliance over time. ,The findings highlight the effectiveness of board of directors’ characteristics in promoting mandatory accounting compliance. As disclosure is fundamental for the effective functioning of capital markets and sound investments, a direct implication is that the quality of financial reporting can be improved by taking these characteristics into account. ,The paper contributes to the literature on the determinants of mandatory accounting compliance. The findings highlight the importance of the board of directors’ role in enhancing transparency and ensuring the quality of financial reporting. The findings will be particularly valuable to those involved in the appointment of directors, who should be aware of the influence of the configuration and characteristics of the board on compliance.
Hepatitis G virus infection in primary Sjögren’s syndrome: analysis in a series of 100 patients

OBJECTIVE To determine the prevalence and clinical significance of hepatitis G virus (HGV) infection in a large cohort of patients with primary Sjögren’s syndrome (SS). PATIENTS AND METHODS The study included 100 consecutive patients (92 female and eight male), with a mean age of 62 years (range 31–80) that were prospectively visited in our unit. All patients fulfilled the European Community criteria for SS and underwent a complete history, physical examination, as well as biochemical and immunological evaluation for liver disease. Two hundred volunteer blood donors were also studied. The presence of HGV-RNA was investigated in the serum of all patients and donors. Aditionally, HBsAg and antibodies to hepatitis C virus were determined. RESULTS Four patients (4%) and six volunteer blood donors (3%) presented HGV-RNA sequences in serum. HGV infection was associated with biochemical signs of liver involvement in two (50%) patients. When compared with primary SS patients without HGV infection, no significant differences were found in terms of clinical or immunological features. HCV coinfection occurs in one (25%) of the four patients with HGV infection. CONCLUSION The prevalence of HGV infection in patients with primary SS is low in the geographical area of the study and HCV coinfection is very uncommon. HGV infection alone does not seen to be an important cause of chronic liver injury in the patients with primary SS in this area.
Like Father, like Son: Toward an Economic Theory of Occupational Following

It used to be common, if not expected, that a son would grow up and take over the family business or follow in his father's footsteps. Although less prevalent today, we still observe varying degrees of occupational following in business, politics, the arts, agriculture, and other occupations. How can the observed pattern of variation in magnitude of occupational following be explained in economic terms? We seek to provide an answer to this question by arguing that following is sometimes an efficient mechanism whereby intergenerational transfers of property rights are effected. In essence, we view wealth transfers between generations as either tangible (cash, real or personal property) or intangible. Intangible transfers take the form of specialized knowledge, goodwill, brand (or name) loyalty, and other types of family-specific capital whose present value cannot be fully captured (realized) by the parent. The value of this family-specific capital can be captured only by children who follow in their parents' occupational footsteps, and diminishes in value if children choose to enter an occupation which is different from that of their parents. From the son's standpoint, inheritance of valuable name-brand capital represents a rent-transfer, whereas the transfer of career-specific human capital requires investment by the recipient-son . The son as recipient of a rent-transfer incurs no opportunity cost; the son in the later category does incur an opportunity cost, as he must spend time with his