Miracle-dz/UniFAR-FTUs huggingface dataset:
Post-exercise Glucose Response Following Whey Protein Ingestion in Healthy Young People: A Randomized Pilot Study

Whey protein may have an effect directly on the muscle to affect exercise glucose response.The study aimed to measure post-exercise glucose recovery with supplementation and the role of DPP-IV and IL-6.Twenty-four participants were randomly assigned to one of three supplementation conditions (CTL: water, WPI: 31g whey protein isolate, and CHO: 32g fructose beverage; WPI and CHO beverages were isocaloric). During the Baseline Visit, participants performed an Oral Glucose Tolerance Test (OGTT) with no exercise or supplementation. On their second and third visits, participants consumed their assigned beverage then completed a maximal treadmill protocol until volitional fatigue. An OGTT was completed on the second visit, and blood samples were collectedviavenipuncture on the third visit for IL-6, Insulin and DPP-IV.Glucose delta peak was attenuated in WPI+exercise by -45±25% and CHO+exercise by -49±21%, compared to baseline (p<0.05). Glucose area under the curve was only attenuated with WPI+exercise (5,993±1,013mg/dl*min), compared to baseline (10,604±4,589mg/dl*min; p<0.05). Insulin was elevated in the WPI+exercise (111±57pmol/L) and CHO+exercise (119±70pmol/L), compared to rest (WPI: 61±40pmol/L; CHO: 78±56pmol/L; p<0.05). IL-6 and DPP-IV activated T-cells (CD26+) were not different among groups. However, plasma DPP-IV was higher in WPI (8±6U/L) compared to CTL (0.7±2U/L) and CHO (0.6±4U/L; p<0.05). We found that a single dose of whey protein given prior to exercise results in elevated DPP-IV activity in the plasma and improved glucose response. Together these data suggest that whey protein as a supplement to exercise may be beneficial for humans trying to manage their blood sugar.
Existence of Optimal Consumption Strategies in Markets with Longevity Risk

Survival bonds are financial instruments with a payoff that depends on human mortality rates. In markets that contain such bonds, agents optimizing expected utility of consumption and terminal wealth can mitigate their longevity risk. To examine how this influences optimal portfolio strategies and consumption patterns, we define a model in which the death of the agent is represented by a single jump process with Cox–Ingersoll–Ross intensity. This implies that our stochastic mortality rate is guaranteed to be nonnegative, in contrast to many other models in the literature. We derive explicit conditions for existence of an optimal consumption and investment strategy in terms of model parameters by analysing certain inhomogeneous Riccati equations. We find that constraints must be imposed on the market price of longevity risk to have a well-posed problem and we derive the optimal strategies when such constraints are satisfied.
How Time Flies for Flies: Diverse Diptera from the Triassic of Virginia and Early Radiation of the Order

Abstract The most diverse and best-preserved early fauna of flies (order Diptera) is described from the Late Carnian (Late Triassic, ca. 220 Ma) of Virginia, USA. Complete flies are preserved as aluminosilicate films on very fine-grained shales from the Cow Branch Formation, which is part of the Newark Supergroup of Early Mesozoic rift basins from eastern North America. The dipteran fauna consists of eight families (one new), 11 genera (five new), and 16 species (11 new), and includes the following taxa (Blagoderov and Grimaldi are the authors of all new names): Architipula youngi Krzemiński, Metarchilimonia krzeminskorum n.gen., n.sp. , and M. solita n.sp. (Limoniidae); Triassopsychoda olseni n.gen., n.sp. (Psychodidae); Culicomorpha indet. ; Yalea argentata (Krzemiński), Y. rectimedia n.sp. , Alinka cara Krzemiński (Procramptonomyiidae); Veriplecia rugosa n.sp. , Virginiptera certa n.gen., n.sp. , V. similis n.sp. , V. lativentra n.sp. (Paraxymyiidae); Brachyrhyphus distortus n.gen. n.sp. (Protorhyphidae); ? Crosaphis virginiensis n.sp. (Crosaphididae); and Prosechamyia trimedia n.gen., n.sp. , P. dimedia n.sp. (Prosechamyiidae, new family). Particularly significant is a culicomorphan with a long proboscis, which is the earliest fossil record of a structure specialized apparently for blood feeding. Also, Prosechamyia appears to be a stem group to the very diverse infraorder Brachycera, the earliest definitive members of which appear in the Early Jurassic. Phylogenetic relationships of major clades of living and extinct nematocerous Diptera are analyzed, indicating that infraordinal-level diversification was complete by the Late Triassic. Flies did not reach modern levels of ecological abundance until the mid-Jurassic, apparently due to diversification within most infraorders by that time.
Non-surgical management of caesarean scar ectopic pregnancy – a five-year experience

Abstract The aim of this paper is to review the diagnosis and treatment of patients with a caesarean scar pregnancy (CSP), who have been managed at our unit, as well as to evaluate the effectiveness of the non-surgical treatment options. Twenty-six cases were identified over a period of 5 years and 4 months (January 2012 until April 2017). The main outcome measures were a number of previous caesarean births, a method of diagnosis of CSP, the mode of treatment and the outcome. The diagnostic criteria on the ultrasound were an empty uterine cavity and cervical canal, the presence of a gestational sac anterior to the isthmic portion of the uterus, an absent or thinned (<5 mm) myometrial thickness between the gestational sac and the bladder, with a peri-trophoblastic circulation around the gestational sac with the colour flow Doppler examination. The diagnosis was confirmed using ultrasound in 25 of the cases (96%) and by laparoscopy in one patient (4%). Fourteen women (54%) were managed conservatively, as there was evidence of a spontaneous resolution. A systemic methotrexate injection was used successfully to treat 11 (42%) patients. Only one patient (4%) needed an additional surgical treatment following an incomplete resolution. Impact Statement What is already known on this subject? A caesarean scar pregnancy is a life threatening condition whose incidence is increasing due to the global increase in the number of caesarean deliveries. Due to the relative rarity of the condition there is no consensus regarding the management of these cases. The management is mainly individualised, depending upon both the gestation and clinical symptoms. Surgical management or an intra-gestational sac injection of methotrexate with or without potassium chloride (KCl) dominates most of the published case reports and the systemic reviews. What the results of this study add? All of our patients in this case series were managed either conservatively with active monitoring, or were treated with an intramuscular methotrexate injection. Only one patient needed an additional minor surgical procedure due to an incomplete medical management. These results are very encouraging, and are attributed to the early diagnosis followed by a prompt treatment. An early detection requires a high index of suspicion, strict diagnostic criteria, and properly trained, experienced sonographers. A complete resolution was slow in some cases but the major high risk surgical procedures were avoided. What the implications are of these findings for clinical practice and/or further research? We wanted the sharing of our experience via this review to play a positive role in guiding the treatment of this rare but increasing subset of ectopic pregnancies.
Effects of a depression-focused internet intervention in slot machine gamblers: A randomized controlled trial

Background Problematic and pathological gambling have been linked to depression. Despite a high demand for treatment and negative financial consequences, only a small fraction of problematic and pathological gamblers seek professional help. The existing treatment gap could be narrowed by providing low-threshold, anonymous internet-based interventions. The aim of the present study was to examine the acceptance and efficacy of an online-intervention for depression (“Deprexis”) in a sample of problematic and pathological slot-machine gamblers. We hypothesized that the intervention group would show a greater reduction in both depressive and gambling-related symptoms compared to a wait-list control group. Method A total of 140 individuals with self-reported gambling and mood problems were randomly allocated either to the intervention group or to a wait-list control group. After 8 weeks, all participants were invited for re-assessment. The Patient Health Questionnaire - 9 (PHQ-9) served as the primary outcome assessment. Problematic gambling was measured with the Pathological Gambling Adaptation of Yale-Brown Obsessive Compulsive Scale (PG-YBOCS) and the South Oaks Gambling Screen (SOGS). The trial is registered with the German Registry for Clinical Studies (DRKS00013888). Results ITT analyses showed that the intervention led to a significant reduction in depressive symptoms as well as gambling-related symptoms compared to the control group, with moderate to strong effect sizes. PP analyses failed to yield significant results due to high rates of non-completion and limited statistical power. Moderator analyses indicated that Deprexis was particularly beneficial in reducing problematic gambling for those scoring high on baseline gambling-related symptoms and for those who gamble due to loneliness. Discussion Results of the present study suggest that Deprexis might be a useful adjunct to traditional interventions for the treatment of problematic gambling. The potential of internet-based interventions that are more targeted at issues specific to gambling should be evaluated in future studies. Trial registration German Registry for Clinical Studies DRKS00013888.
Patient Satisfaction with Psychiatric Services: A Survey at a Nigerian Federal Teaching Hospital

Background: Patient satisfaction, a measure of the extent to which a patient is content with the health care which he or she receives from his or her health care provider, is an effective means of evaluating the performance of a hospital leading to service improvement and attraction of more patients. In a country whose leadership currently calls for change of attitude of the citizenry, it is pertinent to assess how this change has been accepted in health institutions, especially among the most stigmatized group of patients, by assessing the latter’s level of satisfaction with the quality of services provided. Objectives: The study, carried out over a period of six months (1st May to 30th October, 2016), assessed the satisfaction of patients with the quality of care provided at the psychiatric outpatient department of the Federal Teaching Hospital, Abakaliki, Nigeria. Methods: Data were extracted from eligible participants using a sociodemographic/clinical profile questionnaire and the Charleston Psychiatric Outpatient Satisfaction Questionnaire. Results: 422 patients (53.6% males, 46.4% females) participated. Their mean age was 32.20 ± 11.35 years. Schizophrenia was the commonest diagnosis. The respondents appeared quite satisfied with the quality of services. Satisfaction with the helpfulness of the record officers was topmost in the administrative scale (92.9%) with satisfaction with the amount of time waited to be seen by doctor, the least (76.3%) while on the environmental scale, appearance of the doctor’s consulting room was most satisfying (93.4%) and cost of service the least (73.5%). 90.5% were satisfied with the overall quality of service provided and 94.8% indicated willingness to recommend the facility to others. Satisfaction was most affected by self-perceived mental and physical health. Conclusion: Patient satisfaction is a simple way to evaluate hospital services. Continual assessment of patient satisfaction is recommended to enable authorities improve on areas considered less satisfactory while sustaining service areas deemed highly satisfactory.
Comparison of thiocyanate and selenocyanate for potentiation of antimicrobial photodynamic therapy

We have previously shown that antimicrobial photodynamic therapy (aPDT) mediated by different photosensitizers (PS) can be potentiated by a variety of inorganic salts. Potassium thiocyanate (KSCN) potentiated aPDT mediated by methylene blue (MB), while potassium selenocyanate (KSeCN) potentiated aPDT mediated by MB, Rose Bengal and the anionic porphyrin 5,10,15,20‐tetrakis(4‐sulfonatophenyl)porphyrin dihydrochloride. However, the mechanisms of action that were proposed were fundamentally different. In the present study, we compare these two salts (KSCN and KSeCN) with different light‐activated PS and different oxidative reactions for killing gram‐positive and gram‐negative bacteria. Overall KSeCN was more powerful than KSCN, and worked with a wider range of PS, while KSCN only worked with phenothiazinium salts. KSeCN produced killing when cells were added after light suggesting production of a semistable species called selenocyanogen (SeCN)2. We tested three different oxidative reactions that can all potentially kill bacteria: lead tetraacetate (Pb[OAc]4); Fenton reagent (hydrogen peroxide [H2O2] and ferrous sulfate) H2O2and horseradish peroxidase (HRP). In every case, KSeCN was substantially more effective (several logs) than KSCN in potentiating the bacterial killing. We conclude that (SeCN)2 is the mediator for aPDT using KSeCN, while sulfur trioxide radical anion is the mediator for KSCN using phenothiaziums. For H2O2/HRP with KSCN, hypothiocyanite is proposed to be the antibacterial agent in the literature, while hyposelenocyanite is said not to exist. Pb[OAc]4 is known to produce (SeCN)2 from KSeCN as well as the analogous (SCN)2 from KSCN. The mediators from Fenton reaction are unclear (pseudohalogen radical ions? ) Both KSCN (which occurs naturally in the human body) and KSeCN may be clinically applicable.
Going Bone Deep: Osseous Rosai–Dorfman Disease in an Adult with Recurrent, Culture-Negative Osteomyelitis

A patient presented for medical care on three separate occasions over the course of two years with recurrent right knee pain attributed to chronic osteomyelitis. Careful assessment revealed that his symptoms were caused by osseous Rosai–Dorfman disease. This case presents an alternative diagnostic possibility for culture-negative chronic osteomyelitis.
What's in a Trial? On the Importance of Distinguishing Between Experimental Lab Studies and Randomized Controlled Trials: The Case of Cognitive Bias Modification and Alcohol Use Disorders.

OBJECTIVE Recently, the National Institutes of Health (NIH) redefined clinical trials to include any study involving behavioral or biomedical interventions. In line with a general framework from experimental medicine, we argue that it is crucial to distinguish between experimental laboratory studies aimed at revealing psychological mechanisms underlying behavior and randomized controlled trials (RCTs) in clinical samples aimed at testing the efficacy of an intervention. METHOD As an illustration, we reviewed the current state of the evidence on the efficacy of cognitive bias modification (CBM) interventions in alcohol use disorders. RESULTS A recent meta-analysis "cast serious doubts on the clinical utility of CBM interventions for addiction. " That analysis combined experimental laboratory studies and RCTs. We demonstrated that, when studies are differentiated regarding study type (experimental laboratory study or RCT), mode of delivery (controlled experiment or Internet), and population (healthy volunteers or patients), the following effects are found: (a) short-lived effects of CBM on drinking behavior in experimental laboratory studies in students, but only when the bias is successfully manipulated; (b) small but robust effects of CBM on treatment outcome when administered as an adjunct to established treatments in clinical settings in RCTs with alcohol-dependent patients; and (c) nonspecific effects (reduced drinking irrespective of condition) in RCTs of CBM administered online to problem drinkers. CONCLUSIONS We discuss how CBM might be improved when it is better integrated into regular treatment, especially cognitive behavioral therapy, and we conclude that disregarding the difference between experimental laboratory studies and RCTs can lead to invalid conclusions.
Lock-free Contention Adapting Search Trees

Concurrent key-value stores with range query support are crucial for the scalability and performance of many applications. Existing lock-free data structures of this kind use a fixed synchronization granularity. Using a fixed synchronization granularity in a concurrent key-value store with range query support is problematic as the best performing synchronization granularity depends on a number of factors that are difficult to predict, such as the level of contention and the number of items that are accessed by range queries. We present the first linearizable lock-free key-value store with range query support that dynamically adapts its synchronization granularity. This data structure is called the lock-free contention adapting search tree (LFCA tree). An LFCA tree automatically performs local adaptations of its synchronization granularity based on heuristics that take contention and the performance of range queries into account. We show that the operations of LFCA trees are linearizable, that the lookup operation is wait-free, and that the remaining operations (insert, remove and range query) are lock-free. Our experimental evaluation shows that LFCA trees achieve more than twice the throughput of related lock-free data structures in many scenarios. Furthermore, LFCA trees are able to perform substantially better than data structures with a fixed synchronization granularity over a wide range of scenarios due to their ability to adapt to the scenario at hand.
Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates

Organic cation transporter (OCT) 2 mediates the entry step for organic cation secretion by renal proximal tubule cells and is a site of unwanted drug-drug interactions (DDIs). But reliance on decision tree–based predictions of DDIs at OCT2 that depend on IC50 values can be suspect because they can be influenced by choice of transported substrate; for example, IC50 values for the inhibition of metformin versus MPP transport can vary by 5- to 10-fold. However, it is not clear whether the substrate dependence of a ligand interaction is common among OCT2 substrates. To address this question, we screened the inhibitory effectiveness of 20 µM concentrations of several hundred compounds against OCT2-mediated uptake of six structurally distinct substrates: MPP, metformin, N,N,N-trimethyl-2-[methyl(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino]ethanaminium (NBD-MTMA), TEA, cimetidine, and 4–4-dimethylaminostyryl-N-methylpyridinium (ASP). Of these, MPP transport was least sensitive to inhibition. IC50 values for 20 structurally diverse compounds confirmed this profile, with IC50 values for MPP averaging 6-fold larger than those for the other substrates. Bayesian machine-learning models of ligand-induced inhibition displayed generally good statistics after cross-validation and external testing. Applying our ASP model to a previously published large-scale screening study for inhibition of OCT2-mediated ASP transport resulted in comparable statistics, with approximately 75% of “active” inhibitors predicted correctly. The differential sensitivity of MPP transport to inhibition suggests that multiple ligands can interact simultaneously with OCT2 and supports the recommendation that MPP not be used as a test substrate for OCT2 screening. Instead, metformin appears to be a comparatively representative OCT2 substrate for both in vitro and in vivo (clinical) use.
Microwave extraction of Salvia officinalis essential oil and assessment of its GC-MS identification and protective effects versus vanadium-induced nephrotoxicity in Wistar rats models

Abstract In this study, we assess the impact of Salvia officinalis essential oil on renal toxicity induced by vanadium in rats. The animals were exposed to either ammonium metavanadate (5 mg/kg body weight) or the combination of vanadium and S. officinalis essential oil (15 mg EO/kg body weight) for 10 days. Vanadium induced significant renal damage, demonstrated by increased plasma levels of urea and creatinine. A marked increase in lipid peroxidation markers and carbonyl protein levels with a significant decrease in enzymatic antioxidants (SOD), catalase (CAT), and glutathione peroxidase (GPx) was also observed in vanadium-treated rats. Histopathological studies also showed vanadium-induced alterations. Concomitant administration of sage essential oil significantly restored biochemical markers and pathological lesions. This protective effect seems to be due to the richness of this extract in β-caryophyllene, limonene, carvacrol, caryophyllene, borneol and α-pinene, and α-pinene and α-thujene. These rates are determined by GC MS.
The Role of 18-Fluoro-2-Deoxy-Glucose Positron Emission Tomography/Computed Tomography as Response and Prognosis Predictive Factor of Concurrent Chemoradiotherapy after Induction Chemotherapy in Head and Neck Squamous Cell Carcinoma: A Prospective Study

Background and objectives: The importance of induction chemotherapy (ICT) followed by concurrent chemoradiotherapy (CCRT) has been re-established in recent years aiming at fewer metastatic sites and better control of the disease. We prospectively studied the possibility of early prediction of overall survival (OS) and progression-free survival (PFS) after 3 cycles of chemotherapy with doxetacel, cisplatin and 5-fluorouracil using 18-fluoro-2-deoxy-glucose positron emission tomography computed tomography (18F-FDG PET/CT) in patients with head and neck squamous cell cancer. To our knowledge, this is the first such study. Materials and Methods: Thirty-five patients were studied. They underwent an 18F-FDG PET/CT examination twice: a day before ICT and 10–14 days after the last cycle of ICT. Tumor-standardized uptake value (SUVmax) and hypermetabolic tumor volume were measured on both scans. The mean age of patients was 56.5 years. Complete responses to CCRT PFS and OS were calculated. Results: Our results showed that a decrease of ≥30% in the SUVmax value after ICT was a prognostic factor of tumor response to PFS and OS (p = 0.026 and p = 0.021). The groups of patients with a SUVmax between 10 and 14.5 in the primary tumor on a pre-ICT 18F-FDG PET/CT scan had statistically shorter PFS and OS (p = 0.001, p = 0.006) when compared with other groups of patients with SUVmax less than 10 or SUVmax more than 14.5. A decrease of less than 55% of hypermetabolic tumor volume of the primary tumor was significantly related to poor prognosis in PFS and OS (p = 0.033, p = 0.017). Conclusions: SUVmax and hypermetabolic tumor volume measured on 18F-FDG PET/CT after ICT might be valuable prognostic tools for predicting OS and PFS and, thus, for the selection of patients with head and neck cancer who will benefit from CCRT.