Miracle-dz/UniFAR-FTUs huggingface dataset:
Validity of the Play Assessment for Group Settings: an evaluation of differential item functioning between children with specific language impairment and typically developing peers.

AIM The purpose of this study was to evaluate the validity evidence based on internal structure of the Play Assessment for Group Settings (PAGS). METHODS The study was conducted in day care centres by comparing observations of the free play performance of two groups of children: those with specific language impairments (SLIs) (n=55) and those with typical language development (n=55). The participating children were 3 to 6.5 years of age. Data were subjected to many-faceted Rasch analyses and differential item functioning analysis was conducted to identify possible group-specific items in the PAGS. The effect of differentially functioning items on mean play performance measurements between two subgroups of children was controlled with two different independent samples t-tests. RESULTS According to the results, 80% of the test items were stable across the groups of children. Four items were harder for children with SLI, and clearly required language skills. Two items were relatively speaking easier for children with SLI, and reflected explorative functioning. The differential functioning items did not affect the ability of the PAGS to separate the children with SLI in mean play performance from their typically developing peers. CONCLUSION We concluded that the PAGS is a valid tool for identifying children who have challenges in their play performance and can be used for clinical purposes. However, the slight variability supports the fact that differential item functioning should be controlled in research when using the PAGS for comparison of different subgroups in play performance.
Normal range of serum highly-sensitive troponin-T in patients with chronic kidney disease stage 3-5.

BACKGROUND Serum troponin-T concentrations are commonly increased in chronic kidney disease (CKD) without acute coronary syndrome. Highly-sensitive troponin-T the new tool that helpful for diagnosis of acute coronary syndrome, provides few data about normal value in patients with chronic kidney disease. MATERIAL AND METHOD The authors studied 89 patients with CKD stage 3-5: 40 had CKD stage 3, 26 had CKD stage 4 and 23 had CKD stage 5. Serum samples were collected for the analysis of highly-sensitive troponin-T levels. The values of highly-sensitive troponin-T of the total group and each CKD stage were presented. RESULTS The level of highly-sensitive troponin-T in patients with CKD stage 3-5 was 0.044 +/- 0.076 ng/ml. For CKD stages 3, 4 and 5 levels were 0.015 +/- 0.016, 0.043 +/- 0.056, 0.098 +/- 0.121 ng/ml, respectively. 95th percentile of the total group was 0.139 ng/ml. 95th percentile for stage 3, 4 and 5 were 0.052, 0.136, 0.297 ng/ml, respectively. CONCLUSION 95th percentile for highly-sensitive troponin-T of patients with CKD stage 3-5 was 0.139 ng/ml. This number may be considered as the cut-off value for diagnosis of acute myocardial infarction.
Norovirus GII‐4 2006b variant circulating in patients with acute gastroenteritis in Thailand during a 2006–2007 study

Noroviruses (NoVs) are recognized as a significant cause of acute gastroenteritis in children and adults. A 14‐month study, from January 2006 to February 2007, was undertaken in a hospital in Thailand to determine the prevalence and genetic characterization of NoVs in patients of all ages with acute gastroenteritis. Based on reverse transcription‐nested polymerase chain reaction (RT‐nested PCR), NoVs were detected in 122 of 273 (44.7%) collected stool samples. Of the 122 NoV‐positive samples, 28 (23%) belonged to GI, 79 (64.8%) belonged to GII, and 15 (12.2%) were mixed infections of GI and GII strains. Three NoV GI‐positive and 42 NoV GII‐positive samples were characterized successfully by DNA sequencing of the RT‐nested PCR products and phylogenetic analysis. For NoV GI, two genotypes were identified: GI‐2 (one sample) and GI‐6 (two samples). NoV GII could be classified further into five distinct genotypes: GII‐2 (1 sample), GII‐3 (3 samples), GII‐4 (14 samples), GII‐6 (3 samples), and GII‐17 (2 samples), and one unclassified genotype (19 samples). All NoV GII‐4 strains showed 88–98% nucleotide identity with NoV GII‐4 2006b variants reported worldwide. Among genotypes of NoV characterized, one co‐infected stool sample exhibited NoVs GI‐6 and GII‐4 2006b. This study suggests that there is an important role of NoVs as etiologic agents in patients with acute gastroenteritis. The predominant circulating genotype of NoV infections is GII‐4 2006b variant. J. Med. Virol. 82: 854–860, 2010. © 2010 Wiley‐Liss, Inc.
Human brown adipose tissue as a target for obesity management; beyond cold‐induced thermogenesis

Elevating energy expenditure via adaptive thermogenesis in brown adipose tissue (BAT) is a potential strategy to reverse obesity. Much early enthusiasm for this approach, based on rodent studies, was tempered by the belief that BAT was relatively inconsequential in healthy adult humans. Interest was reinvigorated a decade ago when a series of studies re‐identified BAT, primarily in upper thoracic regions, in adults. Despite the ensuing explosion of pre‐clinical investigations and identification of an extensive list of potential target molecules for BAT recruitment, our understanding of human BAT physiology remains limited, particularly regarding interventions which might hold therapeutic promise. Cold‐induced BAT thermogenesis (CIT) has been well studied, although is not readily translatable as an anti‐obesity approach, whereas little is known regarding the role of BAT in human diet‐induced thermogenesis (DIT). Furthermore, human studies dedicated to translating known pharmacological mechanisms of adipose browning from animal models are sparse. Several lines of recent evidence suggest that molecular regulation and physiology of human BAT differ to that of laboratory rodents, which form the majority of our knowledge base. This review will summarize knowledge on CIT and expand upon the current understanding and evidence gaps related to human adaptive thermogenesis via mechanisms other than cold.
Subjective and objective sleepiness in the active individual.

Eight subjects were kept awake and active overnight in a sleep lab isolated from environmental time cues. Ambulatory EEG and EOG were continuously recorded and sleepiness ratings carried out every two hours as was a short EEG test session with eyes open for 5 min and closed for 2 min. The EEG was subjected to spectral analysis and the EOG was visually scored for slow rolling eye movements (SEM). Intrusions of SEM and of alpha and theta power density during waking, open-eyed activity strongly differentiated between high and low subjective sleepiness (the differentiation was poorer for closed eyes) and the mean intraindividual correlations between subjective and objective sleepiness were very high. Still, the covariation was curvilinear; physiological indices of sleepiness did not occur reliably until subjective perceptions fell between "sleepy" and "extremely sleepy-fighting sleep"; i.e. physiological changes due to sleepiness are not likely to occur until extreme sleepiness is encountered. The results support the notion that ambulatory EEG/EOG changes may be used to quantify sleepiness.
Assessing Institutional Ethics Committees in India Using the IRB-RAT

Institutional ethics committees (IECs) are currently still in their infancy in low- to middle-income countries (LMICs), which may have important implications with regard to the oversight of the protection of human participants. Understanding how these IECs currently function is a critical first step in helping LMICs build infrastructures that support the protection of research participants and improve the scientific quality of health research worldwide. We assessed the functioning of the IECs at two medical colleges in Gujarat, India, by administering the Institutional Review Board Researcher’s Assessment Tool (IRB-RAT) to 42 IEC and faculty members. The IRB-RAT includes eight scales assessing various domains related to how investigators and members perceive their ethics committees. Results from t tests revealed significant differences between ideal ratings and descriptive ratings on each of the IRB-RAT scales with ideal ratings being higher than current descriptive ratings on all of the scales (<.001). These findings suggest areas that can be targeted for improvement and also provide important information about the values of Indian IECs.
Alberta Stroke Program Early CT Scoring of CT Perfusion in Early Stroke Visualization and Assessment

BACKGROUND AND PURPOSE: Qualitative CT perfusion (CTP) assessment by using the Alberta Stroke Program Early CT Score (ASPECTS) allows rapid calculation of infarct extent for middle cerebral artery infarcts. Published thresholds exist for noncontrast CT (NCCT) ASPECTS, which may distinguish outcome/complication risk, but early ischemic signs are difficult to detect. We hypothesized that different ASPECTS thresholds exist for CTP parameters versus NCCT and that these may be superior at predicting clinical and radiologic outcome in the acute setting. MATERIALS AND METHODS: Thirty-six baseline acute stroke NCCT and CTP studies within 3 hours of symptoms were blindly reviewed by 3 neuroradiologists, and ASPECTS were assigned. Treatment response was defined as major neurologic improvement when a ≥8-point National Institutes of Health Stroke Scale improvement at 24 hours occurred. Follow-up NCCT ASPECTS and 90-day modified Rankin score (mRS) were radiologic and clinical reference standards. Receiver operating characteristic curves derived optimal thresholds for outcome. RESULTS: Cerebral blood volume and NCCT ASPECTS had similar radiologic correlations (0.6 and 0.5, respectively) and best predicted infarct size in the absence of major neurologic improvement. A NCCT ASPECT threshold of 7 and a cerebral blood volume threshold of 8 discriminated patients with poor follow-up scans (P < .0002 and P = .0001) and mRS ≤2 (P = .001 and P < .001). Only cerebral blood volume predicted major neurologic improvement (P = .02). Interobserver agreement was substantial (intraclass correlation coefficient, 0.69). Cerebral blood volume ASPECTS sensitivity, specificity, positive predictive value, and negative predictive value for clinical outcome were 60%, 100%, 100%, and 45%, respectively. No patients with cerebral blood volume ASPECTS <8 achieved good clinical outcome. CONCLUSION: Cerebral blood volume ASPECTS is equivalent to NCCT for predicting radiologic outcome but may have an additional benefit in predicting patients with major neurologic improvement.
Accumulation of radiolabelled platelets and fibrin on the carotid artery of rabbits after angioplasty: effects of heparin and dipyridamole

Summary We investigated the dynamic accumulation of platelets and fibrin after balloon injury of the carotid arteries in rabbits in vivo. In addition, effects of heparin and dipyridamole treatment were also tested. Autologous 99mTc-labelled platelet and 123I-labelled fibrin accumulation was measured at one minute intervals for 4 hours following balloon injury of the carotid artery. Platelet accumulation occurred rapidly, with a ~125% increase occurring within 30 min after injury. There was no further activity for up to 4 hours. This accumulation could be inhibited with an intravenous infusion of PGI2 (500 ng/kg/hr). Fibrin accumulation occurred slowly and continuously over the 4 hour measurement period. Injection of an anti-fibrin antibody inhibited fibrin accumulation. Heparin (25 U/kg/hr for 4 hrs) administration resulted in a significant 82 ± 19% and 68 ± 13% reduction in platelet and fibrin accumulation, respectively. This dose of heparin was associated with a 2-fold prolongation of the aPTT. Dipyridamole (0.45 mg/kg/hr for 4 hrs) resulted in a 46 ± 12% and 70 ± 25% reduction of platelet and fibrin accumulation, respectively. Thus, we demonstrated that the dynamics of platelet and fibrin accumulation following balloon injury in rabbits are very different. The vessel wall continues to be thrombogenic for fibrin up to 4 hours after injury even though platelet accumulation has ceased after one hour. We conclude that the local thrombotic events following balloon injury are complex and that not only platelets but also fibrin is important in regulating responses to injury.
Emerging roles of the Angiopoietin‐Tie and the ephrin‐Eph systems as regulators of cell trafficking

Vascular receptor tyrosine kinases (RTK) have been identified as critical regulatory signaling molecules of developmental and adult vascular morphogenic processes [vascular endothelial growth factor (VEGF) receptors=sprouting; EphB receptors=assembly; Tie2 receptor=maturation and quiescence]. It is intriguing that the same molecules that control the growth of blood and lymphatic vessels play critical roles in the adult to regulate maintenance functions related to vascular homeostasis. VEGF is among the most potent inducers of vascular permeability. The second vascular RTK system, the interaction of paracrine‐acting Angiopoietin‐1 with its cognate receptor Tie2, acts as an endothelial maintenance and survival‐mediating molecular system, which stabilizes the vessel wall and controls endothelial cell quiescence. The third vascular RTK system, the interaction of Eph receptors with their Eph family receptor‐interacting protein (ephrin) ligands, transduces positional guidance cues on outgrowing vascular sprouts, which are critical for proper arteriovenous assembly and establishment of blood flow. As such, Eph‐ephrin interactions act as an important regulator of cell–cell interactions, exerting propulsive and repulsive functions on neighboring cells and mediating adhesive functions. This review summarizes recent findings related to the roles of the Angiopoietin‐Tie and the Eph‐ephrin systems as regulators of cell trafficking in the vascular system. The recognition of vascular homeostatic functions of vascular RTKs marks an important change of paradigm in the field of angiogenesis research as it relates angiogenesis‐inducing molecules to vascular maintenance functions in the adult. This may also broaden the scope of vascular RTK‐targeted therapies.
Effect of Pre-Loading Oral Glucosamine HCl/Chondroitin Sulfate/Manganese Ascorbate Combination on Experimental Arthritis in Rats

The therapeutic effect of a nutritional supplement consisting of a combination of glucosamine hydrochloride (FCHG49), purified sodium chondroitin sulfate (TRH122), and manganese ascorbate (GCM)3 was investigated in the rat model of collagen-induced autoimmune arthritis (CIA). The GCM compound was mixed with a palatable nutritional paste (Nutri-cal® [NC]). Oral administration of the NC/GCM compound was initiated in 26 rats 10 days before immunization and continued until the day of sacrifice. One group of 12 control rats was given no oral agents; a second group of 12 control rats received NC only. Evaluations included arthritis index (AI) scoring by three independent evaluators, histologic index (HI) scoring of lesions, T-cell proliferation, and serological studies for antibody classes and subclasses. Both the AI and HI criteria showed a statistically significant reduction in the prevalence of CIA in rats pretreated with the NC/GCM (54%) compared to the combined control groups (96%, χ2 analysis P < 0.001). Rats fed the NC/GCM also exhibited a significant decrease in the severity of autoimmune arthritis in both the AI and HI compared to control Group 2 (immunized-NC) (χ2 analysis P < 0.05). Histological studies verified the decreased incidence of arthritis in the NC/GCM group compared to control Group 2. GCM treatment failed to alter T-cell proliferation and antibody production to bovine type-II collagen, indicating that its effects are not due to alteration of the antigen-specific immune response.
Vitamin E regulates changes in tissue antioxidants induced by fish oil and acute exercise.

PURPOSE Prooxidant effects of fish oil supplementation could unfavorably affect the cardiovascular benefits of fish oil. We tested the effects of 8 wk vitamin E cosupplementation with fish oil on antioxidant defenses at rest and in response to exhaustive exercise in rats. METHODS Rats (N = 80) were divided into fish oil, fish oil and vitamin E (FOVE), soy oil, and soy oil and vitamin E (SOVE) supplemented groups. For the vitamin E supplemented rats, corresponding groups (FOVE-Ex and SOVE-Ex) performed an acute bout of exhaustive exercise after the supplementation period. RESULTS Fish oil supplementation increased the activity of catalase, glutathione peroxidase, and glutathione-S-transferase in the liver and red gastrocnemius (RG) muscle. Fish oil decreased liver total glutathione (TGSH) levels. Vitamin E supplementation decreased antioxidant enzyme activities to levels at or near those in SOVE in a tissue specific pattern. Vitamin E increased TGSH in liver, heart, and RG. Regression analysis showed TGSH to be a negative determinant of protein oxidative damage as measured by protein carbonyl levels in both liver and RG. Catalase activity was associated with liver lipid peroxidation as measured by thiobarbituric acid-reacting substances. The exercise-induced decrease in hepatic TGSH tended to be less in FOVE versus SOVE. Exhaustive exercise also modulated tissue antioxidant enzymes. CONCLUSIONS Vitamin E supplementation markedly decreased fish oil induced antioxidant enzyme activities in all tissues. Sparing of glutathione may be an important mechanism by which vitamin E decreased tissue protein oxidative damage.
Outgassing Behavior and Composition of Comet C/1999 S4 (LINEAR) During Its Disruption

The gas activity of comet C/1999 S4 (LINEAR) was monitored at radio wavelengths during its disruption. A runaway fragmentation of the nucleus may have begun around 18 July 2000 and proceeded until 23 July. The mass in small icy debris (≤30-centimeter radius) was comparable to the mass in the large fragments seen in optical images. The mass budget after breakup suggests a small nucleus (∼100- to 300-meter radius) that had been losing debris for weeks. The HNC, H2CO, H2S, and CS abundances relative to H2O measured during breakup are consistent with those obtained in other comets. However, a deficiency in CH3OH and CO is observed.
Social network sites and methodological practices

The internet and its social applications have imposed themselves as the essential tools in people’s everyday life. Social network sites (SNS) researches hence become a lucrative field of study among diverse scholars who have developed and published several studies throughout the past ten years. Drawing on the methodological research work accomplished so far to study SNS and its impact on people and communities around the world, this paper focuses on the type of methodologies practiced in most researches addressing SNS global phenomenon. Hence, the paper queries are: 1) what are the publications trends normally used in publishing SNS literature? 2) What are the research methods commonly practiced in literature? 3) Suggestions for various other methodological options to employ. This paper is grounded on studying an array of 112 research papers published from 2006 to 2016 where articles were identified through a systematic process. Articles followed a four staged process where they were reviewed, analysed, and coded through a qualitative content analysis approach. Findings show the publications in all disciplines are discussing SNS from one angle or another. Secondly, the most used research method by researchers and scholars across various disciplines is quantitative tools mostly online surveys followed with ethnography through observation of content analysis of sites. The mixed methods methodology represents only 9% of the investigated sample. Further, not much research is accomplished about the Middle East region as the analysis presents only 15% mainly focusing on SNS’s usage pattern rather than arising in-depth investigation of changes in people’s life. Recommendations to obtain offline genuine human preferences and opinions gathered through face to face focus group and interviews in addition to online behaviours trending for more informative results and predications. Likewise, for the Middle East region, need to investigate acutely SNS’s impact on changing people pattern of behaviour and cultural structure.
Determinants of Port Performance - Case Study of 4 Main Ports in Indonesia (2005-2015)

Port plays significant role in supporting economic growth of a country. This study aims to analyze the determinant of port performance in Indonesia. In this research, the ports selected are four main ports in Indonesia which are Port of Belawan, Port of Tanjung Priok, Port of Tanjung Perak, and Makassar. These ports are designed as the hub ports in the national sea transport system of the country. The study used pooled OLS as the methodology to analyze the determinant. The result of this studies shows that total traffic is not influenced by operating surplus per ton, whereas the rest of variables such as turnaround time, idle time, berth of occupancy rate, rate of return, number of employee and cargo equipment have significant results and significantly influenced the total traffic.
Sex differences in shared genetic and environmental influences between conduct disorder symptoms and marijuana use in adolescents.

The association between conduct disorder (CD) symptoms and marijuana use (MU) was assessed in 1,480 adolescent twins participating in the National Longitudinal Study on Adolescent Health. A strong association was found between CD and MU for both males (r=.38, P<.01) and females (r=.31, P<.01). Structural equation modeling on age-corrected rank normalized scores using the program Mx indicated significant gender differences in the genetic and environmental contributions to MU. Additive genetic influences were comparable in size for males (29%) and females (24%). However, for females the influence of common environmental influences was greater (58%) than for males (36%). There was also evidence of greater common environmental influences for females, as well as greater genetic influences for males for CD, but these differences did not reach significance. In addition, for CD common environmental influences did not differ significantly from zero. Additive genetic influences accounted for 61% of the variance in CD, with the remainder being of unique environmental origin. Bivariate genetic analyses suggested a moderate genetic correlation between CD and MU (r(g)=. 28) and a low unique environmental correlation (r(e)=. 14). These results suggest that CD and MU share genetic influences, while environmental influences tend to be more specific to each behavior. These findings may have implications for the prevention and treatment of CD and substance use among adolescents.
How not to write about writing about Africa

The aim of this chapter is to highlight a number of significant logical flaws and empirical gaps within the existing literature concerned with Africa’s media image. I begin by drawing on the results of a comprehensive scoping review to show that, despite common assumptions, the existing evidence base in this area is insufficient for reaching firm conclusions about how Africa is represented in the US and UK news media. The irony is that a subject area focused on exposing taken-for-granted assumptions is in fact responsible for maintaining its own myth – that we know how Africa is represented in the news media. I further argue that this myth about the comprehensiveness of existing research has persisted for so long, in part, because of certain citation practices and patterns of interpretation within the literature. Finally, I suggest that repeatedly emphasising only the anticipated and problematic aspects of representations of Africa may, inadvertently, end up serving to reinforce the very same ideas that these studies often seek to challenge. If nothing else, generalised critiques about the apparent limitations of all news coverage of Africa can inhibit constructive dialogue with those responsible for producing such coverage.