Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of exposure with response prevention in the cognitive-behavioural therapy for bulimia nervosa

Background. One hundred and thirty-five women with bulimia nervosa participated in a randomized clinical trial designed to determine whether the addition of exposure with response prevention to a core of cognitive-behavioural therapy (CBT) leads to greater clinical improvement and lower risk of relapse. We present results from the end of treatment and 6- and 12-month follow-up. Methods. Participants received eight sessions of CBT and were then randomized to either exposure to pre-binge cues (B-ERP), exposure to pre-purge cues (P-ERP), or a relaxation training control condition (RELAX). Results. CBT produced significant clinical change. At the end of the behavioural treatments, there were no significant differences across the three groups on abstinence (66% in B-ERP, 45% in P-ERP and 47% in RELAX), or frequency of bingeing and purging. B-ERP, but not P-ERP, significantly reduced anxiety on the cue reactivity assessment, food restriction, body dissatisfaction and depression. These differences were not maintained at 6-month follow-up. At 12-months, B-ERP was independently associated with lower food restriction and better global functioning. Conclusions. CBT is a highly effective treatment for bulimia nervosa. B-ERP was modestly superior to P-ERP at post-treatment; however, the advantage did not remain throughout the follow-up interval. ERP for bulimia nervosa is an expensive and logistically complicated treatment that does not appear to offer any significant additive benefits that are proportional to the amount of effort required to implement the treatment.
Aceruloplasminaemia: A Family with a Novel Mutation and Long-Term Therapy with Deferasirox

Abstract Ceruloplasmin is a member of the multicopper oxidase family that plays a major role in the transport of iron in the body. Aceruloplasminaemia (ACP) is a rare disease and is clinically identified by iron overload in liver, pancreas, brain, and other organs, and by microcytic anaemia. So far, the iron chelator deferasirox was given for therapy only up to 6 months due to side effects. Here, we describe a novel mutation leading to ACP and report for the first time a long-term therapy, that is, 2 years with deferasirox. ACP was diagnosed in 3 siblings using clinical and biochemical characteristics, HFE and ceruloplasmin mutational analysis, liver biopsy, brain-, liver-, and heart-MRI. For iron depletion, a starting dose of deferasirox 7.5 mg/kg/day was increased to 15 mg/kg/day and maintained at 4–7.5 mg/kg/day with a patient follow-up for 2 years. A novel homozygous mutation of the ceruloplasmin gene on chromosome 3 (3q23-q25, exon 12, G708S) was found. Iron was selectively and successfully removed by long-term therapy with deferasirox, as confirmed by follow-up liver biopsies, normalisation of serum ferritin concentrations, and improved glucose metabolism. Unexpectedly, iron depletion ameliorated anaemia. Low-dose deferasirox is an effective and safe long-term treatment option for patients with ACP.
Sexual function in post-stroke patients: considerations for rehabilitation.

INTRODUCTION While the rehabilitation goals of post-stroke patients include improving quality of life and returning to functional activities, the extent to which sexual activity is addressed as part of the standard rehabilitation process is unknown. Moreover, the specific sexual concerns of stroke patients, including the effect of stroke on intimate relationships and sexuality of the partner, the ability to physically engage in sex, and the effect of psychological components such as role identity, depression, and anxiety on sexuality, all warrant examination by rehabilitation professionals. AIM The aim of this study is to examine the existing literature on sexuality and stroke patients in order to better understand how the sexual lives of stroke patients and their partners are affected and to provide recommendations to rehabilitation professionals for addressing sexuality as part of treatment. METHODS Narrative review, PubMed, PEDro, ISI Web of Science, and Google Scholar databases (inception-December 2012) were searched for the key words "stroke," "sexual dysfunction," "sexuality," "quality of life," and their combination. All relevant articles in English and secondary references were reviewed. MAIN OUTCOME MEASURES We report the results of the literature review. RESULTS Sexual dysfunction and decreased sexual satisfaction are common in the post-stroke population and are related to physical, psychosocial, and relational factors. However, they are not adequately addressed in post-stroke rehabilitation. CONCLUSIONS As sexual function is an important component to quality of life and activities of daily living, physicians and rehabilitation specialists, including physical, occupational, and speech therapists, should receive training in addressing sexuality in the treatment of post-stroke patients. Sexologists and sex therapists should be an integral part of the rehabilitation team.
Immunoplatelet counting: a proposed new reference procedure

Given the high degree of interoperator error and poor precision of manual platelet counting, it has recently been proposed that an immunoplatelet counting method could become the new reference procedure. Platelets are identified immunologically with a suitable monoclonal antibody, and the platelet count is derived from the ratio of fluorescent platelet events to collected red blood cell (RBC) events that are also counted by a reliable and calibrated standard impedance counter (RBC ratio). In this study, we have set up a rapid and simple method for immunoplatelet counting and simultaneously compared the RBC ratio with the bead ratio derived from two different preparations of commercial calibration beads (Trucount and FlowCount beads). Comparison of the level of imprecision of the RBC ratio with either the manual count or bead ratios revealed a superior coefficient of variation of < 5% even in samples with a platelet count < 20 × 109/l. The RBC ratio correlated extremely well with the existing manual phase reference method (r2 = 0.93) and especially well with three different commercial impedance counters and a dual‐angle optical counter (r2 = 0.98–0.99). However, at < 100 × 109/l, the correlation of the RBC ratio with the dual‐angle optical count (ADVIA 120) (r2 = 0.96) was superior to all impedance counters. This suggests that automated optical counting methods may be more accurate at determining platelet counts in thrombocytopenic samples. As the RBC ratio is rapid, cheap and relatively easy to perform, we propose that this method could replace the manual count as a new international reference method.
Heat induction of cyclic electron flow around photosystem I in the 11 symbiotic dinoflagellate Symbiodinium 12 13 Author names : 14

Short title: 1 Heat induction of cyclic electron flow in Symbiodinium 2 3 Corresponding author details: 4 The author responsible for distribution of materials integral to the findings 5 presented in this article in accordance with the policy described in the 6 Instructions for Authors (www.plantphysiol.org) is: Jun Minagawa 7 (minagawa@nibb.ac.jp). 8 9 Article title: 10 Heat induction of cyclic electron flow around photosystem I in the 11 symbiotic dinoflagellate Symbiodinium 12 13 Author names: 14 Yusuke Aihara1, Shunichi Takahashi1,2 and Jun Minagawa1,2,* 15 16 Affiliations: 17 1Division of Environmental Photobiology, National Institute for Basic Biology, 18 Nishigonaka 38, Myodaiji, Okazaki 444-8585, Japan 19 20 2Department of Basic Biology, School of Life Science, SOKENDAI (The 21 Graduate University for Advanced Studies), Okazaki 444-8585, Japan 22 23 *Corresponding author 24 25 One-sentence summary: 26 Cyclic electron flow is accelerated under heat stress in Symbiodinium to 27 promote photoprotective thermal energy dissipation. 28 29 Funding information: This was in part supported by JST (Japan Science 30 and Technology Agency) FRS-FNRS (Fonds de la Recherche Scientifique) 31 cooperative program, the Japan Society for the Promotion of Science through 32 Grant-in-Aid for Scientific Research (A), the Ministry of Education, Culture, 33 Plant Physiology Preview. Published on March 7, 2016, as DOI:10.1104/pp.15. 01886
The venous system is the main determinant of hypotension in patients with vasovagal syncope.

AIMS In patients with vasovagal syncope (VVS), a neural reflex appears the main determinant of hypotension leading to loss of consciousness; whether hypotension is mainly due to involvement of the arterial system or the venous system remains a debated issue. The aim of the present study was to assess which of these two systems is responsible for the fall in blood pressure (BP) in patients with VVS; to this end, a haemodynamic study was carried out not only before and during loss of consciousness but also during the recovery phase. METHODS AND RESULTS Beat-to-beat recordings of heart rate (HR), BP (volume-clamp method) and stroke volume (SV) (modelflow method), cardiac output (CO), and total peripheral resistance (TPR) were made at rest, during unmedicated tilt testing (TT) and recovery from loss of consciousness in 18 patients with a history of syncope (age 45+/-23 years) and positive response to TT. Blood pressure showed a significant fall during prodromal symptoms and a further fall at the beginning of loss of consciousness, together with a fall in SV, CO, and HR, and a slight, but significant, increase in TPR. At the beginning of recovery, BP showed a significant increase and a further increase 5 min later, together with an increase in SV, CO, and HR without significant changes in TPR. CONCLUSION These results suggest that in VVS the fall in BP is mainly caused by reduced venous return to the heart. The arterial system does not appear to be the main determinant of the fall of BP; however, the system appears unable to make the appropriate compensatory changes.
Moving deeper into difference : developing meaningful and effective pathways into teacher education for Indigenous adults from remote communities

The purpose of this thesis was to explore why there are so few young Indigenous people from remote communities in Central Australia pursuing and completing a teacher education pathway. This problem is explored primarily through listening to the experiences of remote Indigenous teachers, including the barriers and supports they encountered in becoming qualified teachers themselves. The stories of the teachers are set against the historical, political and policy context of remote Indigenous teacher education in Australia with particular reference to the Northern Territory. The study was conducted using a qualitative methodology, specifically narrative methodology. The intention of the researcher and teacher participants was to inhabit a Post-Colonial Knowledge space where the process of doing the research work together was equally as important as the research outcomes. What emerged was a generative research method, named here as ‘participatory narrative’. This new method generated specific insights into how to do research together in ‘good faith’. The method itself used a collective analysis process drawing on the teacher narratives. The thematic findings from this collective analysis were then further explored through theoretical and philosophical lenses with a specific consideration of the colonial legacy in Australia and the neo colonial reality. The research concludes that if we are to responsibly encourage young Indigenous people from remote communities into teacher education pathways then teacher education itself needs to move into a Post-Colonial Knowledge space. The thesis concludes with a proposed framework for conducting teacher education within this kind of knowledge space.
Psychological factors and visual fatigue in working with video display terminals

OBJECTIVES To examine the part played by psychological factors in complaints about visual health reported by banking officers who work at video display terminals (VDTs). METHODS Out of a population of 385 bank workers, a group of 212 subjects without organic visual disturbances (as determined by opthalmological examination) who share a work environment and job duties was selected. Three questionnaires were administered to these subjects: (a) the NIOSH job stress questionnaire; (b) a questionnaire investigating subjective discomfort related to environmental and lighting conditions of the workplace; (c) a questionnaire on the existence of oculovisual disturbances. Correlation and multiple regression analyses were performed to examine for the presence of predictors of asthenopia. RESULTS Social support, group conflict, self esteem, work satisfaction, and underuse of skills were found to be predictors of visual complaints; social support played a part also as a moderating factor in the stress and strain model; this model accounted for 30% of the variance. Subjective environmental factors, although in some cases significantly correlated with asthenopia, were not found to be strong predictors of the symptoms. CONCLUSIONS Some part of the complaints about visual health reported by VDT workers are likely indirect expressions of psychological discomfort related to working conditions.
Distinct patterns of plasticity in prefrontal cortex neurons that encode slow and fast responses to stress

The prefrontal cortex (PFC) has been implicated in cognitive and affective responses to acute and chronic stress; however, direct evidence for the reactivity or adaptability of PFC neurons to stress is lacking. We followed the unit activity of medial PFC (mPFC) neurons in awake rats during two consecutive exposures to restraint stress or to a non‐aversive novel object. The majority (75%) of mPFC neurons had significant responses to the initial restraint that was differentiated into one of three temporal patterns: (i) phasic increase in firing rate during the restraint period, (ii) slow onset increase in firing rate that was sustained for > 2 h after restraint, and (iii) brief bi‐phasic responses to initiation and termination of restraint. Exposure to a novel object elicited an exposure‐locked phasic response in 40% of the neurons. None of the neurons displayed the sustained activation that was prominent after restraint. A second exposure to the object no longer elicited this phasic response while neurons in the three restraint‐responsive groups modified their firing rate during the second restraint in a manner that was specific to their pattern of response to the first restraint. These findings demonstrate that whereas some mPFC neurons respond phasically to novel stimuli irrespective of their aversive nature, a separate population of PFC neurons responds to a stressful stimulus with a sustained increase in firing rate that persists in the absence of that stimulus. These neurons may be a substrate for adaptive responses that are necessary for behavioral modification.
Antifungal and Airway Remodeling Roles for Murine Monocyte Chemoattractant Protein-1/CCL2 During Pulmonary Exposure to Asperigillus fumigatus Conidia1

Asperigillus fumigatus spores or conidia are quickly eliminated from the airways of nonsensitized individuals but persist in individuals with allergic pulmonary responsiveness to fungus. A. fumigatus-induced allergic airway disease is characterized by persistent airway hyperreactivity, inflammation, and fibrosis. The present study explored the role of CCR2 ligands in the murine airway response to A. fumigatus conidia. Nonsensitized and A. fumigatus-sensitized CBA/J mice received an intratracheal challenge of A. fumigatus conidia, and pulmonary changes were analyzed at various times after conidia. Whole lung levels of monocyte chemoattractant protein-1 (MCP-1/CCL2), but neither MCP-3/CCL7 nor MCP-5/CCL12, were significantly elevated at days 3 and 7 after conidia in nonsensitized mice. MCP-1/CCL2 was significantly increased in lung samples from A. fumigatus-sensitized mice at days 14 and 30 after a conidia challenge. Administration of anti-MCP-1/CCL2 antiserum to nonsensitized mice for14 days after the conidia challenge attenuated the clearance of conidia and significantly increased airway hyperreactivity, eosinophilia, and peribronchial fibrosis compared with nonsensitized mice that received conidia and normal serum. Adenovirus-directed overexpression of MCP-1/CCL2 in A. fumigatus-sensitized mice markedly reduced the number of conidia, airway inflammation, and airway hyperresponsiveness at day 7 after the conidia challenge in these mice. Immunoneutralization of MCP-1/CCL2 levels in A. fumigatus-sensitized mice during days14–30 after the conidia challenge did not affect the conidia burden but significantly reduced airway hyperreactivity, lung IL-4 levels, and lymphocyte recruitment into the airways compared with the control group. These data suggest that MCP-1/CCL2 participates in the pulmonary antifungal and allergic responses to A. fumigatus conidia.
What contributes to vocational excellence? Characteristics and experiences of competitors and experts in WorldSkills London

Modelling Vocational Excellence (MoVE) International is a WorldSkills Member research initiativesupporting:• skills improvement and Competition best practice• international skills benchmarking, and• promotion of vocational excellence to young people, employers and policy makers.MoVE International is the inaugural research project for the WorldSkills Foundation and is alsosupported by Skills Finland, WorldSkills UK, WorldSkills Australia and the Dusseldorp Skills Forum.The research team is a partnership between: University of Tampere, Finland; University of Oxford,UK; and RMIT University, Australia, with support from Deakin University, Australia.The research initiative sets out to produce outcomes relevant to the interests of its majorstakeholder groups. The data produced by the study offers WorldSkills International and individualWorldSkills Members a framework for international benchmarking on skills quality, and a windowinto the WorldSkills experience for Competitors and Experts. Through the research reports,WorldSkills Member organizations will also gain access to global data on WorldSkills Competitorsand Experts which may be applied to improve training and professional development. Importantly,young people are afforded a global voice. In telling their own stories they can share theirexperiences with peers, and provide future Competitors with insights into the experience of beinginvolved in international skill competitions. For WorldSkills International, the data is a source ofpromotional material, and may contribute to event and organizational evaluation.The MoVE research project launches the WorldSkills Foundation’s program of research,engagement and advocacy. MoVE offers the Foundation an opportunity to influence the globaldebate on vocational education and training, and to shift the orientation of VET research away froma ‘deficit’ framework to one which highlights benefits and opportunities (see section 2.2 for a fullerexplanation of these research orientations). The outputs of the 2011 MoVE international research project include this global report and casestudies of the Australian, Finnish and British teams that competed at WorldSkills London 2011.
Physicochemical Factors Influence the Abundance and Culturability of Human Enteric Pathogens and Fecal Indicator Organisms in Estuarine Water and Sediment

To assess fecal pollution in coastal waters, current monitoring is reliant on culture-based enumeration of bacterial indicators, which does not account for the presence of viable but non-culturable or sediment-associated micro-organisms, preventing effective quantitative microbial risk assessment (QMRA). Seasonal variability in viable but non-culturable or sediment-associated bacteria challenge the use of fecal indicator organisms (FIOs) for water monitoring. We evaluated seasonal changes in FIOs and human enteric pathogen abundance in water and sediments from the Ribble and Conwy estuaries in the UK. Sediments possessed greater bacterial abundance than the overlying water column, however, key pathogenic species (Shigella spp., Campylobacter jejuni, Salmonella spp., hepatitis A virus, hepatitis E virus and norovirus GI and GII) were not detected in sediments. Salmonella was detected in low levels in the Conwy water in spring/summer and norovirus GII was detected in the Ribble water in winter. The abundance of E. coli and Enterococcus spp. quantified by culture-based methods, rarely matched the abundance of these species when measured by qPCR. The discrepancy between these methods was greatest in winter at both estuaries, due to low CFU's, coupled with higher gene copies (GC). Temperature accounted for 60% the variability in bacterial abundance in water in autumn, whilst in winter salinity explained 15% of the variance. Relationships between bacterial indicators/pathogens and physicochemical variables were inconsistent in sediments, no single indicator adequately described occurrence of all bacterial indicators/pathogens. However, important variables included grain size, porosity, clay content and concentrations of Zn, K, and Al. Sediments with greater organic matter content and lower porosity harbored a greater proportion of non-culturable bacteria (including dead cells and extracellular DNA) in winter. Here, we show the link between physicochemical variables and season which govern culturability of human enteric pathogens and FIOs. Therefore, knowledge of these factors is critical for accurate microbial risk assessment. Future water quality management strategies could be improved through monitoring sediment-associated bacteria and non-culturable bacteria. This could facilitate source apportionment of human enteric pathogens and FIOs and direct remedial action to improve water quality.
Inhibition of Microcystin-Induced Release of Cyclooxygenase Products from Rat Hepatocytes by Anti-Inflammatory Steroids

Abstract We showed previously that exposure to microcystin causes eicosanoid release. That study was extended further to test the effect of glucocorticoids on microcystin-induced release of [14C]arachidonic acid and its metabolites from rat hepatocytes previously treated with [14C]arachidonic acid. Release of total radioactivity was 4-fold greater from hepatocytes after 2-hr incubation with 1 μM microcystin than after incubation with control medium. Fluocinolone pretreatment decreased the microcystin-induced synthesis and release of prostacyclin by 24 ± 2.6% (P < 0.05) and thromboxane B2 by 39 ± 3% (P < 0.025). Treatment of hepatocyte cultures with either microcystin (1 μM) or steroids had no effect on cell viability or total cell protein. Total radioactivity released into the incubation medium was not affected by glucocorticoid alone. Under these conditions, the quantities of both prostaglandin F2 α and prostaglandin E2 released were not significantly different when control and microcystin-treated cultures were compared. The half-maximal inhibition (IC50) values obtained from the dose-response data for the inhibition of arachidonic acid release by steroids were comparable with normal Cortisol levels in humans. Dose-response curves gave the following rank order of inhibitory potency: fluocinolone > dexamethasone > hydrocortisone. These results suggest that glucocorticoid therapy might be beneficial in microcystin toxicosis.