Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of lifting tasks performed on laterally slanted ground surfaces

Lifting in most industrial environments is performed on a smooth, level ground surface. There are, however, many outdoor work environments (e.g. agriculture and construction) that require manual material handling activities on variable grade ground surfaces. Quantifying the biomechanical response while lifting under these conditions may provide insight into the aetiology of lifting-related injury. The aim of the current study was to quantify the effect of laterally slanted ground surfaces on the biomechanical response. Ten subjects performed both isometric weight-holding tasks and dynamic lifting exertions (both using a 40% of max load) while standing on a platform that was laterally tilted at 0, 10, 20 and 30° from horizontal. As the subject performed the isometric exertions, the electromyographic (EMG) activity of trunk extensors and knee extensors were collected and during the dynamic lifting tasks the whole body kinematics were collected. The whole body kinematics data were used in a dynamic biomechanical model to calculate the time-dependent moment about L5/S1 and the time-dependent lateral forces acting on the body segments. The results of the isometric weight-holding task show a significant (p < 0.05) effect of slant angle on the normalized integrated EMG values in both the left (increase by 26%) and right (increase by 70%) trunk extensors, indicating a significant increase in the protective co-contraction response. The results of the dynamic lifting tasks revealed a consistent reduction in the peak dynamic L5/S1 moment (decreased by 9%) and an increase in the instability producing lateral forces (increased by 111%) with increasing slant angle. These results provide quantitative insight into the response of the human lifter under these adverse lifting conditions.
COMPARATIVE QUALITY ASSESSMENT OF ACETAMINOPHEN IMMEDIATE AND EXTENDED RELEASE TABLETS BY VALIDATED ANALYTICAL

In this study quality performance of acetaminophen tablets were evaluated by using general quality parameters of these tablets like we ight variation, hardness, friability, disintegratio n time were also determined according to established protocols. UV spectroscopi c and RP were validated and used to determine the active ing re with the official specification for friability, uni formity of weight, disintegration time and drug con tent. The results were also subjected to statistical anal ysis. Potency obtained from UV method and HPLC me thods were found similar with statistical t test. Dissolution test results were subjected to further analysis by difference factor (f1), similarity fact or (f2), dissolution efficiency (% DE), ANOVA and Bonferroni test. The results indicated that all the i release. On the other hand and 2 out of 3 extended release brands are found similar.
Effect of experimental hypothyroidism on glomerular filtration rate and plasma creatinine concentration in dogs.

BACKGROUND Hypothyroidism affects renal function in a manner opposite the effects of hyperthyroidism. OBJECTIVE To evaluate the effects of experimentally induced hypothyroidism on glomerular filtration rate (GFR) and basal plasma creatinine concentration in dogs. ANIMALS Sixteen anestrous, female dogs. METHODS Hypothyroidism was induced by administration of (131)I in 8 dogs, and 8 healthy euthyroid dogs acted as controls. Exogenous plasma creatinine clearance (an estimate of GFR) was measured in all dogs before (control period) and 43-50 weeks after induction of hypothyroidism (posttreatment period). Other pharmacokinetic parameters of creatinine were also determined. RESULTS No significant difference was observed for basal plasma creatinine concentration and creatinine clearance between control and hypothyroid dogs in the control period. In the posttreatment period, mean + or - SD creatinine clearance in the hypothyroid group (2.13 + or - 0.48 mL/min/kg) was lower (P < .001) than that of the control group (3.20 + or - 0.42 mL/kg/min). Nevertheless, basal plasma creatinine concentrations were not significantly different between the hypothyroid and control groups (0.74 + or - 0.18 versus 0.70 + or - 0.08 mg/dL, respectively) because endogenous production of creatinine was decreased in hypothyroid dogs (22 + or - 3 versus 32 + or - 5 mg/kg/d, P=.001). CONCLUSION AND CLINICAL IMPORTANCE Hypothyroidism causes a substantial decrease in GFR without altering plasma creatinine concentrations, indicating that GFR evaluation is needed to identify renal dysfunction in such patients.
A Probabilistic Model of Visual Cryptography

The visual cryptography (VC) is a secret sharing scheme where a secret image is encoded into transparencies, and the stacking of any out of transparencies reveals the secret image. The stacking of or fewer transparencies is unable to extract any information about the secret. We discuss the additions and deletions of users in a dynamic user group. To reduce the overhead of generating and distributing transparencies in user changes, this paper proposes a VC scheme with unlimited based on the probabilistic model. The proposed scheme allows to change dynamically in order to include new transparencies without regenerating and redistributing the original transparencies. Specifically, an extended VC scheme based on basis matrices and a probabilistic model is proposed. An equation is derived from the fundamental definitions of the VC scheme, and then the VC scheme achieving maximal contrast can be designed by using the derived equation.
Selecting an acoustic correlate for automated measurement of American English rhotic production in children

Abstract Purpose: A current need in the field of speech–language pathology is the development of reliable and efficient techniques to evaluate accuracy of speech targets over the course of treatment. As acoustic measurement techniques improve, it should become possible to use automated scoring in lieu of ratings from a trained clinician in some contexts. This study asks which acoustic measures correspond most closely with expert ratings of children’s productions of American English /ɹ/ in an effort to develop an automated scoring algorithm for use in treatment targeting rhotics. Method: A series of ordinal mixed-effects regression models were fit over a large sample of children's productions of words containing /ɹ/ that had previously been rated by three trained clinicians. Akaike/Bayesian Information Criteria were used to select the best-fitting model. Result: Controlling for age, sex, and allophonic contextual differences, the measure that accounted for the most variance in speech rating was F3–F2 distance normalised relative to a sample of age- and sex-matched speakers. Conclusion: We recommend this acoustic measure for use in future automated scoring of children’s production of American English rhotics. We also suggest that computer-based treatment with automated scoring should facilitate increases in treatment dosage by improving options for home practice.
Antibacterial Activity and Mechanism of Action of Zinc Oxide Nanoparticles against Campylobacter jejuni

ABSTRACT The antibacterial effect of zinc oxide (ZnO) nanoparticles on Campylobacter jejuni was investigated for inhibition and inactivation of cell growth. The results showed that C. jejuni was extremely sensitive to treatment with ZnO nanoparticles. The MIC of ZnO nanoparticles for C. jejuni was determined to be 0.05 to 0.025 mg/ml, which is 8- to 16-fold lower than that for Salmonella enterica serovar Enteritidis and Escherichia coli O157:H7 (0.4 mg/ml). The action of ZnO nanoparticles against C. jejuni was determined to be bactericidal, not bacteriostatic. Scanning electron microscopy examination revealed that the majority of the cells transformed from spiral shapes into coccoid forms after exposure to 0.5 mg/ml of ZnO nanoparticles for 16 h, which is consistent with the morphological changes of C. jejuni under other stress conditions. These coccoid cells were found by ethidium monoazide-quantitative PCR (EMA-qPCR) to have a certain level of membrane leakage. To address the molecular basis of ZnO nanoparticle action, a large set of genes involved in cell stress response, motility, pathogenesis, and toxin production were selected for a gene expression study. Reverse transcription-quantitative PCR (RT-qPCR) showed that in response to treatment with ZnO nanoparticles, the expression levels of two oxidative stress genes (katA and ahpC) and a general stress response gene (dnaK) were increased 52-, 7-, and 17-fold, respectively. These results suggest that the antibacterial mechanism of ZnO nanoparticles is most likely due to disruption of the cell membrane and oxidative stress in Campylobacter.
Prevalence of enteric parasites in homosexual patients attending an outpatient clinic

A total of 372 pooled stool specimens from 274 homosexual men with diarrhea were submitted for parasitologic examination over a 2.5-year period. Each two-vial pooled specimen set contained portions of stool from 3 consecutive days in Formalin and polyvinyl alcohol. Of the 274 patients, 133 (48.5%) harbored one or more intestinal protozoa, with 161 (43.3%) of the 372 specimens submitted being positive for one or more organisms. The parasites identified included Entamoeba histolytica (71 patients), Giardia lamblia (22 patients), Endolimax nana (106 patients), Entamoeba coli (39 patients), Entamoeba hartmanni (25 patients), Dientamoeba fragilis (3 patients), Iodamoeba bütschlii (2 patients), and Chilomastix mesnili (2 patients). Cryptosporidium sp. (2 patients) and Isospora belli (1 patient) were also detected. Results of this study support the experience of other workers regarding high rates of infection with intestinal parasites in the homosexual population and also indicate that symptomatic individuals belonging to this acquired immunodeficiency syndrome risk group be screened for both common and uncommon intestinal pathogens.
Phylogenetically Diverse Burkholderia Associated with Midgut Crypts of Spurge Bugs, Dicranocephalus spp. (Heteroptera: Stenocephalidae)

Diverse phytophagous heteropteran insects, commonly known as stinkbugs, are associated with specific gut symbiotic bacteria, which have been found in midgut cryptic spaces. Recent studies have revealed that members of the stinkbug families Coreidae and Alydidae of the superfamily Coreoidea are consistently associated with a specific group of the betaproteobacterial genus Burkholderia, called the “stinkbug-associated beneficial and environmental (SBE)” group, and horizontally acquire specific symbionts from the environment every generation. However, the symbiotic system of another coreoid family, Stenocephalidae remains undetermined. We herein investigated four species of the stenocephalid genus Dicranocephalus. Examinations via fluorescence in situ hybridization (FISH) and transmission electron microscopy (TEM) revealed the typical arrangement and ultrastructures of midgut crypts and gut symbionts. Cloning and molecular phylogenetic analyses of bacterial genes showed that the midgut crypts of all species are colonized by Burkholderia strains, which were further assigned to different subgroups of the genus Burkholderia. In addition to the SBE-group Burkholderia, a number of stenocephalid symbionts belonged to a novel clade containing B. sordidicola and B. udeis, suggesting a specific symbiont clade for the Stenocephalidae. The symbiotic systems of stenocephalid bugs may provide a unique opportunity to study the ongoing evolution of symbiont associations in the stinkbug-Burkholderia interaction.
Contextual influences on eating behaviours: heuristic processing and dietary choices

This paper reviews some of the evidence that dietary behaviours are, in large part, the consequence of automatic responses to contextual food cues, many of which lead to increased caloric consumption and poor dietary choices. We describe studies that illustrate how these automatic mechanisms underlie eating behaviours, as well as evidence that individuals are subject to inherent cognitive limitations, and mostly lack the capacity to consistently recognize, ignore or resist contextual cues that encourage eating.
A Novel Differentiation Therapy Approach to Reduce the Metastatic Potential of Basal, Highly Metastatic, Triple-Negative Breast Cancers

Abstract : Low-grade breast cancer is associated with increased differentiation and reduced metastases, suggesting that reprogramming tumor cells to a more differentiated state could improve outcome. Utilizing a novel differentiation therapy approach, We have reprogrammed aggressive, basal, triple-negative Breast Cancer (BrCa) (generally with poor prognosis) towards a less aggressive phenotype by manipulating expression of the key mammary luminal differentiation transcription factor, GATA3. GATA3 is essential for programming undifferentiated mammary cells into a luminal subtype while myoepithelial/basal cells fail to express GATA3. Significantly, GATA3 expression is highly correlated with the luminal, more differentiated BrCa phenotype. We hypothesized that ectopic expression of GATA3 in metastatic, basal BrCa cell lines will reprogram them to a more differentiated, less metastatic phenotype. Over-expressing GATA3 in human basal-type MDA-MB-231 (231-GATA3) breast cancer cells induced significant morphological changes in 2- and 3-D cultures compared to control cells (231-Empty). 231-Empty cells maintained a spindle, elongated morphology, while 231-GATA3 cells became rounded and larger. In 3D Cultrex, 231-GATA3 cells appeared smaller, more organized, and rounded compared to 231-Empty cells. Microarray profiling of 231- GATA3 vs. 231-Empty cells revealed gene expression changes associated with increased adhesion, reduced extracellular matrix remodeling factors and reduced metastasis. Western blot confirmed reexpression of E-cadherin and an increase in cytokeratin-18 in 231-GATA3 cells, indicative of a more luminal phenotype. 231-GATA3 cells showed reduced LOX expression by real time PCR and knock down of GATA3 in the luminal BT474 cell line increased LOX expression. This demonstrates for the first time that GATA3 is an important differentiation factor that reduces the metastatic potential of MDA-MB-231. Ultimately, t
Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

We developed a severe acute respiratory syndrome (SARS) subunit recombinant protein vaccine candidate based on a high-yielding, yeast-engineered, receptor-binding domain (RBD219-N1) of the SARS beta-coronavirus (SARS-CoV) spike (S) protein. When formulated with Alhydrogel®, RBD219-N1 induced high-level neutralizing antibodies against both pseudotyped virus and a clinical (mouse-adapted) isolate of SARS-CoV. Here, we report that mice immunized with RBD219-N1/Alhydrogel® were fully protected from lethal SARS-CoV challenge (0% mortality), compared to ∼ 30% mortality in mice when immunized with the SARS S protein formulated with Alhydrogel®, and 100% mortality in negative controls. An RBD219-N1 formulation Alhydrogel® was also superior to the S protein, unadjuvanted RBD, and AddaVax (MF59-like adjuvant)-formulated RBD in inducing specific antibodies and preventing cellular infiltrates in the lungs upon SARS-CoV challenge. Specifically, a formulation with a 1:25 ratio of RBD219-N1 to Alhydrogel® provided high neutralizing antibody titers, 100% protection with non-detectable viral loads with minimal or no eosinophilic pulmonary infiltrates. As a result, this vaccine formulation is under consideration for further development against SARS-CoV and potentially other emerging and re-emerging beta-CoVs such as SARS-CoV-2.
Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study.

BACKGROUND Although case reports and open studies have reported augmentation with buspirone to be beneficial in the treatment of depression refractory to treatment with a selective serotonin reuptake inhibitor (SSRI), a recently published randomized, placebo-controlled, double-blind study failed to show superiority of buspirone over placebo in this respect. METHOD One hundred two outpatients who fulfilled DSM-IV criteria for a major depressive episode and who had failed to respond to a minimum of 6 weeks of treatment with either fluoxetine or citalopram were included in this double-blind, randomized, placebo-controlled study. After a single-blind placebo wash-in period of 2 weeks while continuing their SSRI, the patients were randomly assigned to adjunctive treatment with either buspirone, 10 to 30 mg b.i. d. , or placebo for 6 weeks. Patients were assessed using the Montgomery-Asberg Depression Rating Scale (MADRS), the Clinical Global Impressions scale (CGI), and visual analogue scales. RESULTS After the first week of double-blind treatment, there was a significantly greater reduction in MADRS score (p = .034) in the buspirone group as compared with placebo. At endpoint, there was no significant difference between treatment groups as a whole, although patients with initially high MADRS scores (> 30) showed a significantly greater reduction in MADRS score (p = .026) in the buspirone group as compared with placebo. CONCLUSION Patients with severe depressive symptoms may benefit from augmentation with buspirone. It cannot be excluded that augmentation with buspirone may speed up the antidepressive response of patients refractory to treatment with fluoxetine or citalopram.
Using metaphors in language teaching and learning

Metaphor analysis has been used in literature, especially in poetry in the past. However, recently, in the past decades, it has been used in second language acquisition as well. With the impact of Lakoff and Turner (1989), the meaning of metaphors has changed their origin by becoming ‘unconscious and automatic’ as Lakoff and Turner state. This study is an investigation of metaphors used in foreign language teaching and learning. Seeking to assess the value of metaphors in language teaching, this paper reports initial results from a study into the effectiveness of metaphors in second/foreign language instruction in an English Language Skills III course, conducted in the first semester of the year 2012, at the department of English Language and Literature, at the Faculty of Languages Cultures and Communications (LCC) at South East European University. Applying content analysis (Leedy & Ormord, 2005) to identify themes biases and meaning, the study investigated students’ attitudes towards English language learning and teaching by using metaphors. Convenience sampling among students enrolled in the third semester identified a non-random sample of students representing 60% of the possible cohort.
HETEROSKEDASTICITY AUTOCORRELATION ROBUST INFERENCE IN TIME SERIES REGRESSIONS WITH MISSING DATA

In this article, we investigate the properties of heteroskedasticity and autocorrelation robust (HAR) test statistics in time series regression settings when observations are missing. We primarily focus on the nonrandom missing process case where we treat the missing locations to be fixed as T → ∞ by mapping the missing and observed cutoff dates into points on [0,1] based on the proportion of time periods in the sample that occur up to those cutoff dates. We consider two models, the amplitude modulated series (Parzen, 1963) regression model, which amounts to plugging in zeros for missing observations, and the equal space regression model, which simply ignores the missing observations. When the amplitude modulated series regression model is used, the fixed-b limits of the HAR test statistics depend on the locations of missing observations but are otherwise pivotal. When the equal space regression model is used, the fixed-b limits of the HAR test statistics have the standard fixed-b limits as in Kiefer and Vogelsang (2005). We discuss methods for obtaining fixed-b critical values with a focus on bootstrap methods and find the naive i.i. d. bootstrap with missing dates fixed to be an effective and practical way to obtain the fixed-b critical values.
Extraction and partial characterization of antioxidant pigment produced by Chryseobacterium sp. kr6

: Pigments synthesized by Chryseobacterium sp. kr6 growing on feather waste were extracted and characterized. The pigment extract was characterized by KOH test, UV-Vis, CIELAB color system, HPLC-DAD-MS, FTIR and its antioxidant capacity was evaluated. A positive bathochromic shift was observed when kr6 colonies or pigment extracts were subjected to alkaline solution (20% KOH) and a λmax at 450 nm was detected for acetone extracts, although no typical fine structure of carotenoids was detected in the electomagnetic spectra. The HPLC profile of the extracted pigment showed that the compound has 3 different peaks with max near 450 nm. The FTIR analysis shows some principal functional groups from a flexirubin-like molecule. The pigmented compound also presents antioxidant activity evaluated by the scavenging of the ABTS radical.
Acitretin suppression of squamous cell carcinoma: Case report and literature review

Retinoids have been used for the treatment and suppression of cutaneous malignancies in patients with basal cell nevus syndrome, xeroderma pigmentosum, and in patients with recurrent skin cancers as a result of immunosuppression for renal transplantation. We report a 40‐year‐old male who began to develop multiple squamous cell carcinomas of the skin after treatment with PUVA for severe psoriasis. The numbers of squamous cell carcinomas increased when acitretin was discontinued and decreased when he was taking the drug at a dose of 25 mg daily. Acitretin should be considered as a maintenance therapy for psoriasis patients developing squamous cell carcinomas as a result of PUVA therapy.
Comparative digestibility of energy and nutrients in diets fed to sows and growing pigs

The objective of this research was to compare values for digestible energy (DE) and metabolisable energy (ME) and apparent total tract digestibility (ATTD) of nutrients in 11 diets fed to both growing pigs and gestating sows. Three diets were based on corn, wheat or sorghum and eight diets were based on a combination of corn and soybean meal, canola meal, conventional distillers’ dried grains with solubles, low-fat distillers’ dried grains with solubles, corn germ meal, corn bran, wheat middlings or soybean hulls. A total of 88 gestating sows (252 ± 24.2 kg BW; parity two to six) and 88 growing barrows (40 ± 4.7 kg BW) were used and randomly allotted to the 11 diets with eight replicate sows or pigs per diet. Faecal and urine samples were collected for 4 d following a 19 d adaptation period. The DE, ME and ATTD of gross energy (GE), acid detergent fibre (ADF), neutral detergent fibre (NDF) and crude protein (CP) in the 11 diets were calculated. Gestating sows had greater (p < 0.05) ATTD of GE and CP and DE values for all diets compared with growing pigs. Gestating sows also had greater (p < 0.05) ME values than growing pigs for the three grain diets and the diets containing wheat middlings and soybean hulls. No differences were observed in ATTD of ADF and NDF between gestating sows and growing pigs for any of the diets, except that gestating sows had greater (p < 0.05) ATTD of NDF than growing pigs when they were fed the four protein diets. The ATTD of GE and CP and DE values in gestating sows may be predicted by using equations generated from the values of ATTD of GE and CP and DE values obtained in growing pigs. Results of this research indicate that ATTD values of CP and GE obtained in gestating sows are greater than the values obtained in growing pigs, but values for ATTD of ADF obtained in growing pigs are not different from values in gestating sows.