Miracle-dz/UniFAR-FTUs huggingface dataset:
Late Cretaceous through Neogene deep-sea benthic foraminifera(Maud Rise, Weddell Sea, Antarctica)

Upper abyssal to lower bathyal benthic foraminifers from ODP Sites 689 (present water depth 2080 m) and 690 (present water depth 2941 m) on Maud Rise (eastern Weddell Sea, Antarctica) are reliable indicators of Maestrichtian through Neogene changes in the deep-water characteristics at high southern latitudes. Benthic foraminiferal faunas were divided into eight assemblages, with periods of faunal change at the early/late Maestrichtian boundary (69 Ma), at the early/late Paleocene boundary (62 Ma), in the latest Paleocene (57.5 Ma), in the middle early Eocene to late early Eo­ cene (55-52 Ma), in the middle middle Eocene (46 Ma), in the late Eocene (38.5 Ma), and in the middle-late Miocene (14.9-11.5 Ma). These periods of faunal change may have occurred worldwide at the same time, although specific first and last appearances of deep-sea benthic foraminifers are commonly diachronous. There were minor faunal changes at the Cretaceous/Tertiary boundary (less than 14°7o of the species had last appearances at Site 689, less than 9% at Site 690). The most abrupt benthic foraminiferal faunal event occurred in the latest Paleocene, when the diversity dropped by 50% (more than 35% of species had last appearances) over a period of less than 25,000 years; after the extinction the diversity remained low for about 350,000 years. The highest diversities of the post-Paleocene occurred during the middle Eocene; from that time on the diversity de­ creased steadily at both sites. Data on faunal composition (percentage of infaunal versus epifaunal species) suggest that the waters bathing Maud Rise were well ventilated during the Maestrichtian through early Paleocene as well as during the latest Eocene through Recent. The waters appeared to be less well ventilated during the late Paleocene as well as the late middle through early late Eocene, with the least degree of ventilation during the latest Paleocene through early Eo­ cene. The globally recognized extinction of deep-sea benthic foraminifers in the latest Paleocene may have been caused by a change in formational processes of the deep to intermediate waters of the oceans: from formation of deep waters by sinking at high latitudes to formation of deep to intermediate water of the oceans by evaporation at low latitudes. Benthic foraminiferal data (supported by carbon and oxygen isotopic data) suggest that there was a short period of in­ tense formation of warm, salty deep water at the end of the Paleocene (with a duration of about 0.35 m.y.), and that less intense, even shorter episodes might have occurred during the late Paleocene and early Eocene. The faunal record from the Maud Rise sites agrees with published faunal and isotopic records, suggesting cooling of deep to intermediate waters in the middle through late Eocene.
Realizar pesquisa sem ação ou pesquisa-ação na área de Administração? Uma reflexão metodológica

El objetivo en este articulo es analizar como la investigacion-accion se ha aplicado en los estudios del area de Administracion en Brasil. Se presenta un recorte de la investigacion-accion en estudios brasilenos en Administracion y se analizan 44 revistas nacionales de Administracion y 38 simposios o reuniones de la Anpad, entre los anos 2000 y 2010. Se han encontrado 22 articulos en revistas y cuatro en eventos de la Anpad que tenian como referencia la investigacion-accion, sin embargo, solo 21 articulos componen el contenido final de articulos examinados. Se han analizado objetivos, procedimientos, nivel de compromiso de outsiders y consecuencias del ciclo academico y el ciclo de accion, tanto para la ciencia como para la realidad bajo intervencion. Los resultados del estudio indican que, en general, los autores no distinguen adecuadamente las dos intenciones de la metodologia, salvo pocas excepciones. Entonces, se hacen conjeturas acerca del uso de la investigacion-accion en el campo de estudio de Administracion en Brasil. Se concluye que el concepto de investigacion-accion es reconocido e internalizado por los autores, sin embargo, la informacion sobre su aplicacion es todavia deficiente. Finalmente, se argumenta que investigacion y accion en el area de Administracion pueden y deben caminar juntas, y se proponen algunas sugerencias para estudio.
Title : CLK 2 is an oncogenic kinase and splicing regulator in breast cancer

Authors’ Affiliations: Department of Medical Oncology, and Center for Functional Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. Department of Medicine and Pathology, Harvard Medical School, Boston, Massachusetts, USA. Department of Medicine and Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA. Seoul National University College of Medicine, Seoul, Korea. Memorial Sloan-Kettering Cancer Center, New York, New York, USA. Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, China. MD Anderson Cancer Center, Houston, TX. Harvard Stem Cell Institute, Cambridge, Massachusetts, USA. Broad Institute, Cambridge, Massachusetts, USA. Present address: Eisai Co., Ltd., Tokyo, Japan. Present address: Boston Scientific, St. Paul, MN 55112, USA Present address: Maimonides Medical Center, Brooklyn, NY 11219, USA Present address: Daiichi Sankyo Co., Ltd., Tokyo, Japan
Patient preferences for cardiac rehabilitation and desired program elements.

BACKGROUND Data evaluating the efficacy of traditional cardiac rehabilitation programs to meet patient needs are limited. The authors studied patient-perceived preferences in cardiac rehabilitation programs and desired program elements to evaluate differences by gender or age. METHODS The authors surveyed 199 patients (136 men, 60.0 +/- 11.6 years; 63 women, 63.7 +/- 12.7 years; P = 0.045) discharged from a tertiary referral hospital with acute myocardial infarction. Participants completed a standardized questionnaire regarding enrollment in rehabilitation and preferences for six program types on a 10-point scale (1 = little or no agreement, 10 = strongly agree). RESULTS In this study, 54.3% of subjects enrolled in cardiac rehabilitation. Older patients (> or = 65 years) were more likely to enroll in home-based programs compared with younger patients (< 65 years) (11.8% versus 1.4%, P = 0.02). Younger patients preferred a short-term rehabilitation facility more than older patients (7.4 +/- 3.5 versus 5.1 +/- 4.1 units on the 10-point scale, P = 0.001), and rated the following more favorably than older patients: local health club programs (6.2 +/- 3.7 versus 4.5 +/- 4.0, P = 0.01), long-term programs (6.5 +/- 3.8 versus 4.9 +/- 4.2, P = 0.02), and comprehensive programs (6.6 +/- 3.7 versus 4.9 +/- 2.2, P = 0.02). Younger patients rated the following program elements more favorably compared with older patients: stress management (7.0 +/- 3.5 versus 5.7 +/- 4.1, P = 0.04), vocational counseling (5.1 +/- 3.9 versus 1.9 +/- 2.4, P = 0.001), and smoking cessation (4.9 +/- 4.4 versus 2.7 +/- 3.4, P = 0.001). CONCLUSIONS Program preferences differed significantly by age, but not gender. Older patients enrolled in home-based programs over clinic-based programs. Younger patients rated stress management, vocational counseling, and smoking cessation more favorably than older patients. Strategies to enhance patient participation in cardiac rehabilitation should incorporate patient age and preferences for program types and elements.
Postpartum anoestrus in five seasonally-calving dairy farms in Victoria, Australia.

OBJECTIVE A cross-sectional study of seasonally-calving dairy cows in south-western Victoria to quantify the prevalence of anoestrus and to assess the effect of body condition score (BCS), days in milk (DIM) at mating start date (MSD) and age on the likelihood of being diagnosed as anoestrus. METHODS Age, DIM and BCS details were collected from 1795 cycling and 1399 cows diagnosed as anoestrus in five seasonally-calving dairy herds in Victoria. Multivariable logistic regression was used to quantify the association between BCS, DIM and age and the probability of being diagnosed as anoestrus. RESULTS The apparent prevalence of anoestrus in cows that took part in the study was 44% (95% confidence interval (CI) 42-46%). The risk of anoestrus increased with decreases in DIM and BCS. There was a significant interaction between BCS and DIM. For cows >90 DIM at MSD (the reference category) the odds of anoestrus in cows with BCS <4.00 was 8.05-fold (95% CI 3.2-20.2) that of cows of BCS ≥4.50. The risk of anoestrus decreased with increases in cow age. Cows aged 2 and 3-5 years had 2.4-fold (95% CI 1.79-3.22) and 1.4 (95% CI 1.11-1.77) odds of anoestrus, respectively, compared with cows aged ≥6 years. CONCLUSION Reproductive management to maximise the number of days calved at MSD and nutritional management to ensure cows are in BCS >4.5 at mating will reduce the prevalence of anoestrus in Victorian dairy herds.
Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum

Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (1–3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1–4 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED50 of 3.6 μg/mL.
A Novel Low-Power Low-Voltage CMOS 1-Bit Full Adder Cell with the GDI Technique

The power-delay product is a direct measurement of the energy expanded per operational cycle of an arithmetic circuit. Lowering the supply voltage of the full adder cell to achieve low power-delay product is a sensible approach to improve the power efficiency at sustainable speed of arithmetic circuits composed of such instances at high level design. In this paper, a novel design of a low power 1-bit full adder cell is proposed, where the GDI technique has been used for the simultaneous generation of XOR and XNOR functions. Simulation results are performed by HSPICE based on 0.18 m µ CMOS technology, shows that the new full adder circuit outstrips many latest designs in energy efficiency and has the lowest power-delay product over a wide range of voltages among several low-power adder cells of different CMOS logic styles.
Gender Differences in Self-Perceptions About Aging and Sleep Among Elderly Chinese Residents in Taiwan

Background: Previous research has revealed the existence of gender differences in sleep patterns among older adults from various ethnic groups. Data on how gender affects the sleep patterns of Taiwanese are limited. Purpose: The purposes of the current study were to (a) describe perceptions about aging and the influence of these perceptions on sleep in elderly men and women, respectively, and (b) determine whether there are gender differences in perceptions and appraisal of sleep. Methods: A mixed method design was used. In-depth interview data from 23 men and 27 women were integrated with data from the Chinese version of the Pittsburgh Sleep Quality Index (CPSQI). Results: The mean CPSQI score for the entire sample was 6.1 ± 3.5 (men: 4.8 ± 1.6, women: 7.1 ± 4.3). Participants who held negative attitudes about aging were more likely to report poor sleep quality, short sleep duration, and difficulty in falling asleep than those who did not hold negative attitudes. Women had more negative perceptions about aging (e.g., feelings of powerlessness) and more sleep complaints than men. Furthermore, women reported significantly poorer sleep quality (p = .02) and lower sleep efficiency (p = .03) on the CPSQI than men. Conclusions/Implications for Practice: Negative perceptions about aging are associated with reports of poor sleep quality. There are gendered differences in perceptions about aging and appraisals of sleep. As the process of aging and patterns of sleep change over time, longitudinal research designs are recommended for future studies.
Cardiovascular Manifestations of Hypothyroidism

Background: In hypothyroidism the heart muscle is weakened in both its contraction phase, and also its relaxation phase. This means that the heart cannot pump as vigorously as it should, and the amount of blood it ejects with each heart beat is reduced. In addition, because heart muscle does not relax normally in between heart beats, a potentially serious condition called diastolic dysfunction may result. Aim: To evaluate the Prevalence of cardiovascular disorders in patients with primary hypothyroidism, and the relationship between these disorders and other factors like Age, Sex, BMI, and thyroid function status.
Evaluation of Process Variations in Noncompliance in the Implementation of Evidence‐Based Sepsis Care

Introduction: Sepsis is recognized as an often‐lethal disease. Recommended guidelines are complex and time sensitive. Response teams (RTs) have demonstrated success in implementation of quality initiatives. The purpose of this study was to evaluate variations in noncompliance with recommended sepsis guidelines overall and between a sepsis‐focused RT and standard care. Methods: This retrospective chart review categorized septic patients based on treatment by a sepsis response team (SRT) versus standard care (non‐SRT). Guideline compliance was based upon the Surviving Sepsis evaluation and treatment guidelines. Results: Patient records for 123 identified septic patients post first‐year implementation were evaluated. Overall, compliance rates were low and there were variations in compliance between the treatment providers. The SRT was more compliant than the non‐SRT. SRT noncompliance was more often due to failure to achieve therapeutic goals within the recommended time. Mortality benefit was not statistically significant between groups; however mortality was higher in the non‐SRT group. Conclusion: Noncompliance is more complex than simple failure to initiate, especially in time‐dependent therapies. The development and education of an RT demonstrates improvement in application of sepsis‐focused therapies over standard care.
Testing Wallace's intuition: water type, reproductive isolation and divergence in an Amazonian fish

Alfred Russel Wallace proposed classifying Amazon rivers based on their colour and clarity: white, black and clear water. Wallace also proposed that black waters could mediate diversification and yield distinct fish species. Here, we bring evidence of speciation mediated by water type in the sailfin tetra (Crenuchus spilurus), a fish whose range encompasses rivers of very distinct hydrochemical conditions. Distribution of the two main lineages concords with Wallace's water types: one restricted to the acidic and nutrient‐poor waters of the Negro River (herein Rio Negro lineage) and a second widespread throughout the remaining of the species’ distribution (herein Amazonas lineage). These lineages occur over a very broad geographical range, suggesting that despite occurring in regions separated by thousands of kilometres, individuals of the distinct lineages fail to occupy each other's habitats, hundreds of metres apart and not separated by physical barrier. Reproductive isolation was assessed in isolated pairs exposed to black‐water conditions. All pairs with at least one individual of the lineage not native to black waters showed significantly lower spawning success, suggesting that the water type affected the fitness and contributed to reproductive isolation. Our results endorse Wallace's intuition and highlight the importance of ecological factors in shaping diversity of the Amazon fish fauna.
The influence of the natural environment and climate on life satisfaction in Australia

The narrative of the twentieth century is dominated by three key trends: population growth, economic growth and urbanisation. Moreover, these trends are expected to continue well into the twenty-first century. Australia has not been immune to these trends. Australia’s population is projected to increase by 65% to over 35 million by 2049, and be accompanied by an average growth in per-capita Gross Domestic Product of 1.5% per annum. Much of this population and economic growth will be concentrated in an already highly urbanised environment. As a consequence, the natural environment in which the majority of Australians live is likely to undergo rapid change. It is useful therefore, to better understand our relationship with this environment. Using data from the Household, Income and Labour Dynamics in Australia (HILDA) survey, the Census of Population and Housing, and Geographic Information Systems (GIS), this paper examines the link between the natural environment and life satisfaction in Australia. The results indicate that certain natural environmental assets, such as national parks and the coastline are amenities, whereas creeks are disamenities. In regards to the influence of climate on life satisfaction, some unexpected results are found.
Radiotherapy for Esophageal Cancer Using Simultaneous Integrated Boost Techniques: Dosimetric Comparison of Helical TomoTherapy, Volumetric-Modulated Arc Therapy (RapidArc) and Dynamic Intensity-Modulated Radiotherapy

This study compared TomoTherapy (TM), with Volumetric-Modulated Arc Therapy (RapidArc, RA), and dynamic intensity-modulated radiotherapy (dIMRT) for locally advanced esophageal cancer (LAEC) with a simultaneous integrated boost (SIB) technique with regard to the target coverage and sparing of organs at risk (OARs). Twelve patients receiving four-dimensional computed tomography simulation were enrolled for dosimetric comparison. Gross tumor volume was contoured with the maximum intensity projection method. Using an SIB method, Planning target volume low (PTVL) and planning target volume high (PTVH) were prescribed as 54 Gy and 60 Gy, respectively, each administered in 30 fractions. We compared the results of statistical analysis for target coverage, homogeneity index (HI) and conformity index (CI) of PTVs, parameters of OARs and monitor unit (MU) were compared for analysis. The HI for PTVH varied significantly for the 3 techniques of TM, RA, and dIMRT (4.38 ± 0.86, 6.40 ± 0.86, and 6.11 ± 0.68, respectively; P < 0.001). The CI scores for PTVH also differed across TM, RA, and dIMRT (0.64 ± 0.06, 0.53 ± 0.06, and 0.59 ± 0.05, respectively; P < 0.001). The HI for PTVL showed a significant difference among TM, RA, and dIMRT (15.44 ± 0.88, 20.88 ± 1.03 and 18.65 ± 1.42, respectively; P < 0.001). The percentage of lung volume receiving 5 Gy (V5) and 20 Gy (V20) (for V5: TM 54.4 ± 8.0%; RA 67.5 ± 14.5%, P <0.01; dIMRT 44.8 ± 8.2%; for V20: 13.6 ± 3.3%, 12.2 ± 3.6%, 18.1 ± 3.4%, P = 0.001, respectively). For RA, the lung V5 ≥ 65% was observed in 6 patients and the V10 ≥ 50 % in one patient. TM, RA and dIMRT provided comparable coverage of the target and sparing of OARs. TM demonstrated superior CI and HI for tumor coverage and lowered the specified dose parameters for lung. RA provided an advantage in terms of the lowest MU and V20 of the lung, but its higher lung V5 was of some concern about lung toxicity.
Neuropsychological symptoms associated with low-level exposure to solvents and (meth)acrylates among nail technicians.

OBJECTIVE To evaluate reports of neuropsychological symptoms among women occupationally exposed to products commonly used in nail studios. BACKGROUND Typical preparations found in nail studios contain a variety of organic solvents (e.g., toluene, acetone, formaldehyde) and (meth)acrylates with known neurotoxic properties. Little research has focused on the neuropsychological sequelae of exposure to these substances occurring in the cosmetics industry. METHOD Participants included nail salon technicians (n = 150) and controls (n = 148). Nail technicians were compared with demographically similar controls using the Neuropsychological Impairment Scale, a self-reported measure of neuropsychological and psychological symptoms. Aspects of the workplace environment (e.g., square footage of the salon, adequacy of ventilation, hours worked) also were assessed. RESULTS A MANOVA revealed small but significant differences in the overall level of symptoms as well as in individual scales measuring neurologic complaints, cognitive efficiency, memory, verbal learning, and academic skills (p < 0.001). Moreover, nail technicians were significantly more likely to score above the clinical cutoffs than were controls on four of the seven clinical scales and two of the three summary indices. Multiple regression analysis indicated that the severity of symptoms was associated with level of occupational exposure (p < 0.01). The cumulative impact of workplace size and ventilation were most strongly associated with symptom severity. CONCLUSIONS Exposure to low-level neurotoxins common to nail studios results in the self-reported experience of cognitive and neurologic symptoms similar to other types of solvent and (meth)acrylate exposure. The profile of reported symptoms is consistent with deficits typically observed in this type of neurotoxic exposure: neurologic complaints as well as perceived problems with cognitive efficiency, memory, and learning. Additionally, the nail technicians reported a higher overall level of complaints and greater severity of symptoms than did the controls.
Information Transduction Capacity of Noisy Biochemical Signaling Networks

Noise limits information transfer through a single signaling pathway in a single cell to just one bit. Molecular noise restricts the ability of an individual cell to resolve input signals of different strengths and gather information about the external environment. Transmitting information through complex signaling networks with redundancies can overcome this limitation. We developed an integrative theoretical and experimental framework, based on the formalism of information theory, to quantitatively predict and measure the amount of information transduced by molecular and cellular networks. Analyzing tumor necrosis factor (TNF) signaling revealed that individual TNF signaling pathways transduce information sufficient for accurate binary decisions, and an upstream bottleneck limits the information gained via multiple integrated pathways. Negative feedback to this bottleneck could both alleviate and enhance its limiting effect, despite decreasing noise. Bottlenecks likewise constrain information attained by networks signaling through multiple genes or cells.