Miracle-dz/UniFAR-FTUs huggingface dataset:
Self-Criticism and Dependency in Female Adolescents: Prediction of First Onsets and Disentangling the Relationships Between Personality, Stressful Life Events, and Internalizing Psychopathology

There is substantial evidence that personality traits, such as self-criticism and dependency, predict the development of depression and anxiety symptoms, as well as depressive episodes. However, it is unknown whether self-criticism and dependency predict the first onset of depressive and anxiety disorders, and unclear how to characterize dynamic mechanisms by which these traits, stressful life events, and psychopathology influence one another over time. In this study, 550 female adolescents were assessed at baseline, 528 and 513 of whom were assessed again at Waves 2 and 3, respectively, over the course of 18 months. Self-criticism and dependency were assessed with self-report inventories, depressive and anxiety disorders were assessed with diagnostic interviews, and stressful life events were assessed via semistructured interview. Logistic regression analyses showed that self-criticism and dependency significantly predicted the first onset of nearly all depressive and anxiety disorders (significant polychoric rs ranged from .15–.42). Subsequent path analyses focused on prediction of depression, and supported several conceptual models of personality-stress-psychopathology relationships. In particular, Personality × Stress interactions were evident for both dependency and self-criticism. These interactions took the form of dual vulnerability, such that stressful life events predicted an increased probability of a later depressive disorder only at low levels of each trait. Results suggest the traits of self-criticism and dependency are important to consider in understanding who is at risk for depressive and anxiety disorders.
CD44v6 Expression in Intraductal Papillary Mucinous Neoplasms of the Pancreas

Objectives: The purpose of this study was to examine CD44v6 expression in intraductal papillary mucinous neoplasms (IPMNs) and clarify the role of CD44v6 in progression, invasion, metastasis, and morphogenesis of IPMNs. Methods: One hundred fifty-one samples of IPMNs and 30 normal controls were subjected to immunohistochemical analysis for CD44v6. The IPMNs were divided into 4 groups according to the grade of atypia (adenoma, borderline IPMN, noninvasive carcinoma, and invasive carcinoma) and 5 subtypes according to histological phenotype (gastric, intestinal, pancreatobiliary, oncocytic, and unclassified). Correlations were investigated between CD44v6 expression and clinicopathological characteristics including grade of atypia, subtype, lymph node metastasis, and invasion pattern. Results: Whereas normal ductal epithelium did not express CD44v6, CD44v6 expression was observed from the early stage of IPMNs and up-regulated in the progression of IPMNs to invasive carcinoma. CD44v6 expression in intestinal-type IPMNs was significantly lower compared with that in other subtypes. Whereas no correlation was observed between lymph node metastasis and CD44v6 expression in invasive IPM carcinomas, the invasion pattern was significantly correlated to CD44v6 expression. Conclusions: The present data indicate that CD44v6 expression determines the morphology and aggressiveness of IPMNs and is involved in development and invasion of IPMNs.
Prosthetic and extremity survivorship after limb salvage for sarcoma. How long do the reconstructions last?

Ninety-three consecutive prosthetic reconstructions performed for limb salvage after the resection of sarcomas of the lower extremity were reviewed to determine how long the reconstructions lasted, how successful they were in avoiding amputation in the long term, how significant a problem was aseptic loosening, and what was the associated patient survival. Reconstruction was of the proximal femur in 16, distal femur in 61 and proximal tibia in 16 patients. Minimum follow-up time was 24 months, with a median of 66 months and mean of 80 months. If any event leading to the removal of the prosthesis is considered a reason for failure, the event-free prosthetic survival at five years for the proximal femur was 88%, distal femur 59%, and proximal tibia 54%. Limb survival at five years was significantly better, with the proximal femur at 88%, distal femur at 88%, and proximal tibia at 78% intact. Aseptic loosening survival was better than the event free prosthetic survival, which demonstrates the influence of factors such as sepsis (hematogenous) or wound necrosis that lead to prosthetic removal. Aseptic loosening survivorship of the proximal femur at five years was 100%; distal femur, 78%; and the proximal tibia, 73%. At five years, patient survival was low for the proximal femur (62%) and distal femur (75%) but notably better for the proximal tibia (93%). Prosthetic, extremity, and patient survival differed depending on the site. Wound necrosis was a significant cause of prosthetic removal and loss of limb early in this series, but the more aggressive use of soft tissue procedures has improved this. (ABSTRACT TRUNCATED AT 250 WORDS)
Extraordinarily high leaf selenium to sulfur ratios define 'Se-accumulator' plants.

BACKGROUND AND AIMS Selenium (Se) and sulfur (S) exhibit similar chemical properties. In flowering plants (angiosperms) selenate and sulfate are acquired and assimilated by common transport and metabolic pathways. It is hypothesized that most angiosperm species show little or no discrimination in the accumulation of Se and S in leaves when their roots are supplied a mixture of selenate and sulfate, but some, termed Se-accumulator plants, selectively accumulate Se in preference to S under these conditions. METHODS This paper surveys Se and S accumulation in leaves of 39 angiosperm species, chosen to represent the range of plant Se accumulation phenotypes, grown hydroponically under identical conditions. RESULTS The data show that, when supplied a mixture of selenate and sulfate: (1) plant species differ in both their leaf Se ([Se](leaf)) and leaf S ([S](leaf)) concentrations; (2) most angiosperms show little discrimination for the accumulation of Se and S in their leaves and, in non-accumulator plants, [Se](leaf) and [S](leaf) are highly correlated; (3) [Se](leaf) in Se-accumulator plants is significantly greater than in other angiosperms, but [S](leaf), although high, is within the range expected for angiosperms in general; and (4) the Se/S quotient in leaves of Se-accumulator plants is significantly higher than in leaves of other angiosperms. CONCLUSION The traits of extraordinarily high [Se](leaf) and leaf Se/S quotients define the distinct elemental composition of Se-accumulator plants.
The cuprizone model: regional heterogeneity of pathology

The cuprizone model is a model of de‐ and remyelination secondary to oligodendrocyte death, likely to be mediated by an inhibition of mitochondrial function. The aim of this study was to characterize histopathological changes associated with de/remyelination in grey and white matter at different disease stages in C57Bl/6 mice after per oral administration of cuprizone. Oligodendrocyte loss, astrocytosis and complement activation was detected in areas of demyelination. Demyelination, astrocytosis and complement activation occurred earlier in the cerebral cortex than in the corpus callosum. There was no perivascular lymphocyte infiltration. Microglia‐ and macrophage activation was observed in the corpus callosum, but not in the cerebral cortex. After cuprizone exposure was stopped, remyelination was extensive in the corpus callosum, but scarce in the cortex. In conclusion, cortical demyelination and oligodendrocyte loss in the cuprizone model may be due to a direct effect on oligodendrocyte mitochondrial function, as it occurs in the absence of microglial activation. The histopathology of de/remyelination in the cuprizone treated mice show regional heterogeneities which suggest differences in the underlying pathophysiology. Cuprizone‐induced demyelination is a relevant model for the study of regional heterogeneity of demyelination and lesion pathology in multiple sclerosis.
Effect of early furosemide administration in neonates with respiratory distress syndrome

The effect of early furosemide‐induced diuresis was prospectively evaluated in 39 neonates less than 24 hr of age with clinical respiratory distress syndrome (RDS) who received either four doses of furosemide (1 mg/kg) or no diuretic. Measurements of Fio2 alveolararterial oxygen gradient (P[A‐a]O2), peak inspiratory pressure (PIP), and urine output as a fraction of intake (O/l) were averaged for every 8 hr. The furosemide group overall showed a significant decrease (P < 0.01) in Fio2, P[A‐a]O2, and PIP with an earlier (32 hr vs 52 hr) and more pronounced diuresis (35% greater O/l) when compared to the controls. This effect was accentuated in the subgroup with 1,000–1,500 g birth weight (significantly lower Fio2 and P(A‐a)o2 from 16 to 48 hours), while no increase in urine output was observed for the infants weighing less than 1,000 g. A significant reduction in supplemental oxygen and need for ventilatory support at 96 hr of age was observed in the furosemide‐treated, less than 1,500‐g infants. The incidence of patent ductus arteriosus was not increased following furosemide therapy, and no significant difference in echocardiographic parameters was observed in 21 infants from both groups, who were followed daily during the first week of life. This study suggests that early furosemide‐induced diuresis, particularly in infants weighing 1,000–1,500 g at birth, promotes improvement in pulmonary functions in RDS and leads to faster reduction in oxygen and ventilatory support.
Phosphorylation of the RNA polymerase II largest subunit during Xenopus laevis oocyte maturation

Xenopus laevis oogenesis is characterized by an active transcription which ceases abruptly upon maturation. To survey changes in the characteristics of the transcriptional machinery which might contribute to this transcriptional arrest, the phosphorylation status of the RNA polymerase II largest subunit (RPB1 subunit) was analyzed during oocyte maturation. We found that the RPB1 subunit accumulates in large quantities from previtellogenic early diplotene oocytes up to fully grown oocytes. The C-terminal domain (CTD) of the RPB1 subunit was essentially hypophosphorylated in growing oocytes from Dumont stage IV to stage VI. Upon maturation, the proportion of hyperphosphorylated RPB1 subunits increased dramatically and abruptly. The hyperphosphorylated RPB1 subunits were dephosphorylated within 1 h after fertilization or heat shock of the matured oocytes. Extracts from metaphase II-arrested oocytes showed a much stronger CTD kinase activity than extracts from prophase stage VI oocytes. Most of this kinase activity was attributed to the activated Xp42 mitogen-activated protein (MAP) kinase, a MAP kinase of the ERK type. Making use of artificial maturation of the stage VI oocyte through microinjection of a recombinant stable cyclin B1, we observed a parallel activation of Xp42 MAP kinase and phosphorylation of RPB1. Both events required protein synthesis, which demonstrated that activation of p34(cdc2)off kinase was insufficient to phosphorylate RPB1 ex vivo and was consistent with a contribution of the Xp42 MAP kinase to RPB1 subunit phosphorylation. These results further support the possibility that the largest RNA polymerase II subunit is a substrate of the ERK-type MAP kinases during oocyte maturation, as previously proposed during stress or growth factor stimulation of mammalian cells.
Oral imaging as a diagnostic tool for assessing osseous changes

Practical use of images for diagnosis of osseous, abnormalities presumes cost‐effective technology that targets known physiologic processes. The most obvious modalities for such applications are radiographic, and the newest are characterized by quantitative methods expressed both tomographically and by means of digital subtraction registered in two and three dimensions. Quantitative nuclear medicine and possibly electron spin resonance spectroscopy also appear promising. New analytic techniques for interpreting osseous images include characterization of trabecular patterns by fractal descriptors and micromorphometry.
Amlodipine/valsartan single pill combination therapy in Chinese patients not controlled on previous monotherapy.

The majority of hypertensive patients requires combination therapy to reach target blood pressure (BP), usually a value <140/90 mmHg (1,2). On the basis of data available from published hypertension treatment trials, a rule of thumb has recently been proposed whereby approximately a third or less of unselected hypertensive patients will have their BP controlled with a single agent while two third need at least two drugs (3).
Hollow Square- and Ring-Plate MEMS Oscillators Embedded in a Phase-Locked Loop for Low Limit of Detection in Liquid

This letter demonstrates hollow plate microelectromechanical-system oscillators implemented into a digital phase-locked loop (PLL). The resonators feature innovative geometries: hollow square and ring plates, operating in Lamé or Kirkhope modes, respectively, with resonance frequencies comprised between 24 and 78 MHz. Advantageously, the ring-plate resonator presents better frequency stability when compared with its counterpart square plate. The PLL provides a real-time monitoring of the oscillators' frequency shift, which was tested by changing the electrostatic actuation amplitude. Ring-plate resonators show sensitivity between 38 and 232 Hz/V. Finally, the feedback loop was operated with a square-plate device filled with an aqueous solution demonstrating a sensitivity of up to 284 Hz/V.
Signaling by the Cytokine Receptor Superfamily a

Abstract: A variety of cytokines that regulate functions of multiple lineages share the utilization of receptors that are structurally and functionally related and are referred to as the cytokine receptor superfamily. These receptors associate with one or more of the four mammalian Janus kinases (Jaks) and ligand‐induced receptor aggregation results in their activation. Critical roles for Jak3 and Jak2 are demonstrated by the phenotypes of mice that lack each gene. Among the substrates of the Jaks are one or more of the seven members of the signal transducers and activators of transcription (Stats). Each Stat family member plays a critical role in the biological functions of specific cytokines as demonstrated by the phenotype of mice lacking one or more of these genes.
Generalized Levitin--Polyak Well-Posedness in Constrained Optimization

In this paper, we consider Levitin--Polyak-type well-posedness for a general constrained optimization problem. We introduce generalized Levitin--Polyak well-posedness and strongly generalized Levitin--Polyak well-posedness. Necessary and sufficient conditions for these types of well-posedness are given. Relations among these types of well-posedness are investigated. Finally, we consider convergence of a class of penalty methods and a class of augmented Lagrangian methods under the assumption of strongly generalized Levitin--Polyak well-posedness.
Physician patient questionnaire to assess physician patient agreement at the consultation.

OBJECTIVE The primary aim of this study was to validate an instrument of physician-patient agreement in the consultation. A secondary aim was to assess this agreement. METHOD The setting was a county in the southwest of Sweden with a cross-sectional survey of primary care patients and physicians using separate coded questionnaires. Forty-six physicians and 316 patients aged 16 or more with a new complaint lasting 1 week or more. Thirteen items were evaluated and index of proportional agreement for the dichotomized answers agree (P(pos)) and disagree (P(neg)) was calculated. RESULTS In 10 of the 13 items, a high level of agreement between physician and patient was seen. Discussion. Index of proportional agreement was useful in finding statements in a questionnaire on agreement for both physicians and patients that could be used for educational purposes and as a check-up for the GP in daily practice.
Prognostic significance of Ki-67 proliferation index in supratentorial fibrillary astrocytic neoplasms.

Histological grading of fibrillary astrocytic neoplasms has proved to be a valuable prognostic tool, but potentially could benefit from more objective data, such as estimates of proliferative rate. The authors have investigated the prognostic utility of quantitative Ki-67 immunoreactivity in a prospective survival analysis of 36 adult patients with astrocytoma, anaplastic astrocytoma, or glioblastoma multiforme diagnosed between 1987 and 1992. A digital image analyzer was used to assay proliferation indices (PIs) in surgical biopsy specimens obtained at first diagnosis (32 of 36) or at a second biopsy of histologically unchanged high-grade disease (4 of 36). A Ki-67 PI of > or = 7.5% was associated with higher histological grade and poorer survival, and the Ki-67 PI was more significantly related to survival (P < 0.001) than histological grade as determined by a modified Ringertz grading system (P = 0.002). Survival analysis within histological grades suggested that astrocytoma patients with PI > or = 3% may be at increased risk for shorter survival than those with PI < 3%.
Cooperative Intelligent Transport Systems in Europe: Current Deployment Status and Outlook

The cooperative intelligent transport system (C-ITS) (also known as connected vehicle technology in the United States) is an application using vehicle-to-vehicle (V2V) and vehicle-to-infrastructure (V2I) communications, at a carrier frequency of 5.9 GHz, to increase road traffic safety and efficiency in Europe. In this article, we hope to shed light on the current status of the C-ITS in Europe and the activities that must be accomplished before deployment can commence in 2019, the date announced by the CAR-2-CAR Communication Consortium (C2C-CC). There is immense activity regarding the launch of the C-ITS in Europe, and the automotive industry is also currently planning for the future.
Mycobacterium marinum infections in man

Mycobacterium marinum, formerly known as ‘Mycobacterium balnei’, is a free-living organism which causes disease in fish and occasionally in man. When such infections occur in man they are usually associated with some aquatic activity, e.g. swimming, fishing, boating and keeping tropical fish. For this reason, the organism has been called a ‘leisure-time pathogen’ by Feldman, Long & David (1974) and the disease a ‘hobby hazard’ by Heineman, Spitzer & Pianphongsant (1972).
The Relationship of Lipoprotein (a) (Lp(a)) to Risk Factors of Coronary Heart Disease: Initial results of the prospective epidemiological study on Company employees in Westfalia

Lp(a) concentrations were determined in 987 male and 477 female company employees in Westfalia, in the age range 17-70 years. These values were then related to age and to the following risk factors: obesity, smoking, hypertension, hypertriglyceridaemia, hypercholesterolaemia, hyperbetalipoproteinaemia, hypoalphalipoproteinaemia, hyperglycaemia and hyperuricaemia. The Lp(a) values showed a similar markedly skewed distribution for both men and women. The median for men was 0.039 g/l, for women 0.050 g/l. In both sexes only about 25% of all Lp(a) values were above 0.10 g/l. Raised Lp(a) values (greater than 0.30 g/l) were found in 6.5% of males and in 6.1% of females. A significantly higher frequency of raised Lp(a) values (greater than 0.30 g/l) was found in: post-menopausal women (11.3% as against 4.1%, p less than 0.01); females with hypercholesterolaemia (19.0% when cholesterol values were greater than or equal to 6.73 mmol/l, 10.8% when cholesterol values were between 5.70-6.72 mmol/l, 3.0% when cholesterol values were less than 5.70 mmol/l, p less than 0.001); and females with hyperbetalipoproteinaemia (22.6% when LDL cholesterol values were greater than or equal to 4.92 mmol/l, 5.0% when LDL cholesterol values were less than 4.92 mmol/l, p less than 0.001). 12.0% of men with hypoalphalipoproteinaemia (HDL cholesterol values less than 0.907 mmol/l) had Lp(a) values greater than 0.30 g/l, as against 5.5% of men with HDL cholesterol values greater than or equal to 0.907 mmol/l (p less than 0.01). This percentage rate increased to 16.9% when hypertriglyceridaemia (greater than or equal to 2.28 mmol/l triglycerides) was also present. All other risk factors which were examined and their combinations had no significant influence on the prevalence of raised Lp(a) concentrations.
The moderating role of human capital management practices on employee capabilities

Purpose – The purpose of this paper is to suggest and empirically test a model that explains employee capabilities from the knowledge‐based perspective. In this model, human capital management practices are employed as a moderator variable.Design/methodology/approach – A valid research instrument was utilized to conduct a survey of 14,769 current employees of a major North American financial services institution. The model was tested by using the partial least squares (PLS) structural equation modeling technique. A thorough analysis of the role of moderator was carried out.Findings – Findings provide support for the proposed model and show that employee capabilities depend on his or her training and development as well as job satisfaction levels. Job satisfaction in turn is affected by training and development, pay satisfaction, supervisor satisfaction, and job insecurity. These relationships are moderated by employee perceptions of human capital management practices. The model exhibits the highest predic.
Jurisdictional protectionism in online news: Am erican journalists and their perceptions of hyperlinks

Because of their widespread use on the internet, hyperlinks have become a useful tool in information sharing and knowledge distribution in online communication, particularly in the realm of journalism. Their importance has received little scholarly attention, however. Against the backdrop of the sociology of professions, the purpose of this study is to determine how journalists approach hyperlinks and what they perceive to be their functions in online news. A national survey of newspaper editors and TV news directors in the United States shows that American journalists exhibit a sense of jurisdictional protectionism in online news. They appear to privilege US hyperlinks over foreign ones, especially internal links to their own websites. They are also predominantly against linking to foreign news media that cover the same events or issues. Financial consideration seems to be the main reason behind the journalistic preference.
Human Perception of Jitter and Media Synchronization

Multimedia synchronization comprises both the definition and the establishment of temporal relationships among media types. The presentation of 'in sync' data streams is essential to achieve a natural impression, data that is 'out of sync' is perceived as being somewhat artificial, strange, or even annoying. Therefore, the goal of any multimedia system is to enable an application to present data without no or little synchronization errors. The achievement of this goal requires a detailed knowledge of the synchronization requirements at the user interface. The paper presents the results of a series of experiments about human media perception that may be used as 'quality of service' guidelines. The results show that skews between related data streams may still give the effect that the data is 'in sync' and gives some constraints under which jitter may be tolerated. The author uses the findings to develop a scheme for the processing of nontrivial synchronization skew between more than two data streams.