Miracle-dz/UniFAR-FTUs huggingface dataset:
The Prevalence of Personality Disorders Among Those with Eating Disorders

The genuine prevalence of personality disorders among those with eating disorders is unknown. However, in this paper, we summarize the existing data, with careful acknowledgment of our approach to interpretation as well as the limitations of previous studies. Our findings indicate that obsessive-compulsive personality is the most common personality disorder in restricting-type anorexia nervosa, while borderline personality is the most common personality disorder in binge-eating/purging type anorexia nervosa. Borderline personality is the most common personality disorder in bulimia nervosa, as well. In those with binge eating disorder, obsessive-compulsive personality is the most common personality disorder although, compared with the preceding eating disorder diagnoses, there are broader clusters of personality disorders represented in this group. We discuss the implications of these findings.
Increasing platelet concentration in platelet‐rich plasma inhibits anterior cruciate ligament cell function in three‐dimensional culture

Tissue engineering is one new strategy being developed to treat ACL ruptures. One such approach is bio‐enhanced ACL repair, where a suture repair is supplemented with a bio‐active scaffold containing platelets. However, the optimal concentration of platelets to stimulate ACL healing is not known. We hypothesized that increasing platelet concentrations in the scaffold would enhance critical cell behaviors. Porcine ACL fibroblasts were obtained from explant culture and suspended in platelet poor plasma (PPP), 1× platelet‐rich plasma (PRP), 3× PRP, 5× PRP, or phosphate buffered saline (PBS). The cell suspensions were cultured in a 3D collagen scaffold. Cellular metabolism (MTT assay), apoptosis (TUNEL assay), and gene expression for type I and type III collagen were measured. 1× PRP significantly outperformed 5× PRP in all parameters studied: Type I and III collagen gene expression, apoptosis prevention, and cell metabolism stimulation. ACL fibroblasts cultured with 1× PRP had the highest type I and type III collagen gene expression. 1× PRP and PPP groups had the highest cell metabolism and lowest apoptosis rates. Concentration of platelets had significant effects on the behavior of ACL fibroblasts; thus, it is an important parameter that should be specified in clinical or basic science studies. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:291–295, 2014.
A Decomposed Negative Binomial Model of Structural Change: A Theoretical and Empirical Application to U.S. Agriculture

"We developed a single-equation decomposed negative binomial regression model (NBRM) of the U.S. farm sector to simultaneously evaluate structural changes in the U.S. agricultural sector and the strength of several economic forces that influenced the changes in farm structure during the" 1960-96 "period. We found all these forces reinforced economic incentives to increase the size and decrease the number of small farms. Only agricultural programs and machinery prices countered these forces. " Copyright 2005 Canadian Agricultural Economics Society.
Infertilité masculine chez les patients normospermiques : analyse protéomique des spermes normaux non fécondants en fécondation in vitro classique § Unexpected in vitro fertilization failure in patients with normal sperm : A proteomic analysis

Objective. – Despite normal sperm parameters, 5% of in vitro fertilization (IVF) attempts result in an unpredictable failure of fertilization. In 56% of the cases, there is no obvious oocyte anomaly, but lack of sperm binding to the zona pellucida. This study aims to contribute to clarify the male molecular causes of failures in IVF, which are undetected by classical sperm analysis. Patients and methods. – The spermatic proteomic profiles of patients, with a complete failure of fertilization and no spermatozoa bound to the zona pellucida, is compared to controls (patients with normal fertilization and cleavage rates after a classical IVF for tubal indication). All samples Gynécologie Obstétrique & Fertilité 37 (2009) 796–802 § Cet article fait suite à une communication présentée lors de la Journée thématique de la Société française d’étude de la fertilité (SFEF), qui s’est tenue le 25 mars 2009 à Paris. * Auteur correspondant. Adresse e-mail : jacqueline.mandelbaum@tnn.aphp. fr (J. Mandelbaum). 1297-9589/$ – see front matter # 2009 Publié par Elsevier Masson SAS. doi:10.1016/j.gyobfe. 2009.07. 014 are analysed by 2 Dimensional Electrophoresis-Differential In Gel Electrophoresis (2DE-DIGE) after being divided into three fractions according to their isoelectric point (acid, intermediate and basic). Results. – Fourteen proteins differentially expressed between all the cases and all the controls were highlighted. Twelve of these proteins were identified by mass spectrometry (six from the acid fraction and six from the basic fraction). Two of these proteins may have an interest in gametic interaction: the laminin receptor LR67 and the L-xylulose reductase. Discussion and conclusion. – More investigation is needed to understand the involvement of the identified proteins in the IVF fertilization failure of the infertile patients in this study. # 2009 Published by Elsevier Masson SAS.
Studies on two populations of Ixodes kingi Bishopp (Ixodidae).

Studies on tick size, distribution, and hosts are made of two populations of Ixodes kingi Bishopp, the individuals of which appear to differ only in size. In Canada large specimens were collected only in Alberta and mainly from carnivores and ground squirrels, while small specimens were found only in British Columbia and mostly on pocket gophers and mice but occasionally on weasels. A study of available United States material revealed a similar pattern, the two populations being separated by the Rocky Mountains and the Wasatch Range, but each containing a scattered few specimens of intermediate size. It was shown that individuals of the two populations will interbreed and yield viable F2 larvae. It is suggested that the species is in a state of evolutionary divergence northwards.
On the mechanics of elastomer shear pads for remote center compliance (RCC)

The mechanical behaviour of RCC devices using elastomer shear pads is influenced by the number of rubber-metal layers, thickness and radius of the rubber and metal, and axial and lateral stiffness of the rubber (elastomer). These parameters have to be considered for a complete analysis or design of the RCCs. We present a useful method of analyzing the behaviour of RCC based on the basic knowledge of the mechanics of materials. This makes it easy to design a new RCC for a specific purpose. Simulation and experimental results are also presented.
Association of sleep adequacy with more healthful food choices and positive workplace experiences among motor freight workers.

OBJECTIVES We assessed whether adequate sleep is linked to more healthful eating behaviors among motor freight workers and whether it mediates the effects of workplace experiences. METHODS Data were derived from a baseline survey and assessment of permanent employees at 8 trucking terminals. Bivariate and multivariate regression models were used to examine relationships between work environment, sleep adequacy, and dietary choices. RESULTS The sample (n = 542) was 83% White, with a mean age of 49 years and a mean body mass index of 30 kg/m(2). Most of the participants were satisfied with their job (87.5%) and reported adequate sleep (51%); 30% reported job strain. In our first model, lack of job strain and greater supervisor support were significantly associated with adequate sleep. In our second model, educational level, age, and adequate sleep were significantly associated with at least 2 of the 3 healthful eating choices assessed (P < .05). However, work experiences were not significant predictors of healthful food choices when adequate sleep was included. CONCLUSIONS Adequate sleep is associated with more healthful food choices and may mediate the effects of workplace experiences. Thus, workplace health programs should be responsive to workers' sleep patterns.
Improved Healing Efficacy in Canine Ulnar Segmental Defects With Increasing Recombinant Human Bone Morphogenetic Protein-2/Allograft Ratios

Objectives: A validated canine critical-sized segmental defect model was used to compare efficacy of volumetric ratios of recombinant human bone morphogenetic protein-2 (rhBMP-2)/absorbable collagen sponge (ACS) with cancellous allograft bone or biphasic calcium phosphate ceramic granules using radiographic, biomechanical, and histologic analyses. Methods: Eighteen mixed-breed hounds received bilateral critical-sized ulnar segmental defects. The six treatment groups included 1:5, 1:2, and 1:1 volumetric ratios of rhBMP-2/ACS to cancellous allograft chips; a 1:1 volumetric ratio of rhBMP-2/ACS to biphasic calcium phosphate ceramic granules; iliac crest autograft alone; and cancellous allograft chips alone (n = 6 ulna per group). Animals were euthanized at 12 weeks and analyzed by radiography, torsion testing, and histology. Results: rhBMP-2/ACS groups demonstrated higher radiographic union than autograft or allograft at 12 weeks. Both treatment groups receiving a 1:1 ratio demonstrated union rates of 100% (12/12 ulna) compared with 17% (1/6) and 0% (0/6) for autograft and allograft, respectively. Torsion testing to failure demonstrated significant increases in maximum torque for all rhBMP-2 groups compared with autograft, but no differences between the rhBMP-2 groups. Ulnae treated with the 1:1 volume ratio of rhBMP-2/ACS to ceramic had the highest histologic union grades followed by 1:1 and 1:2 volume ratios of rhBMP-2/ACS to allograft. Conclusions: In this study, efficacy of the treatment correlated with the ratio of rhBMP-2/ACS to allograft. As volume of rhBMP-2/ACS decreased below a 1:1 volume ratio, the overall efficacy decreased, thus indicating a potential limit to extending rhBMP-2/ACS past a 1:1 volumetric ratio in large segmental defects. Furthermore, ceramic was found to be a successful replacement for cancellous allograft bone at a 1:1 volumetric ratio. Clinical application using graft expanders or bone void fillers with rhBMP-2 should be used carefully and requires further investigation.
The role of antioxidants in the Mediterranean diets: focus on cancer

The incidence of certain cancers in the Mediterranean area is lower than in other areas of the world (e.g. in northern Europe and the USA). As nutrition and dietary factors comprise one of the three major factors for human carcinogenesis, the hypothesis was formulated that the dietary profile of the Mediterranean diet, rich in antioxidants, might exert preventive actions. Alas, the vast majority of experiments to prove this hypothesis have been obtained in vitro, and most of the necessary information on the absorption, distribution and metabolism of oligonutrients is currently lacking. Yet, even though the exact role of antioxidants in the Mediterranean diet is yet to be fully established, data from observational studies are strong enough to reinforce the notion that a diet low in saturated fat and alcohol and rich in plant food and whole grain, such as the traditional Mediterranean diet, is associated with lower risk of cancer and should be actively promoted.
Modeling of thundercloud screening charges: Implications for blue and gigantic jets

[1] A two-dimensional axisymmetric model of charge relaxation in the conducting atmosphere is used in conjunction with a probabilistic lightning model to demonstrate how realistic cloud electrodynamics lead to the development of blue and gigantic jets. The model accounts for time-dependent conduction currents and screening charges formed under the influence of the thundercloud charge sources. Particular attention is given to numerical modeling of the screening charges near the cloud boundaries. The modeling results demonstrate the important role of the screening charges in local enhancement of the electric field and/or reduction of net charge in the upper levels of the thundercloud. The charge relaxation model presented in this work confirms the previous results obtained with a simpler model by Krehbiel et al. (2008), specifically that the accumulation of screening charges near the thundercloud top produces a charge configuration leading to the initiation of blue jets, while the effective mixing of these charges with the upper thundercloud charge may lead to the formation of gigantic jets.
Pyruvate orthophosphate dikinase mRNA organ specificity in wheat and maize.

Polyadenylated RNA was isolated from leaves and seeds of a C(3) plant (Triticum aestivum L. cv Cheyenne, CI 8885) and from a C(4) plant (Zea mays L. cv Golden bantam). Each polyadenylated RNA preparation was translated in vitro with micrococcal nuclease-treated reticulocyte lysate. When the in vitro translation products were probed with antibodies to pyruvate orthophosphate dikinase (PPDK) (EC 2.7.9.1), two sizes of polypeptide were identified. A 110 kilodalton polypeptide was found in the in vitro translation products of mRNA isolated exclusively from leaves of both wheat and maize. A 94 kilodalton polypeptide, similar to the PPDK polypeptide which can be extracted after in vivo synthesis in maize and wheat leaves and seeds, was found in the in vitro translation products obtained from wheat seeds and maize kernels.These results indicate that the mRNAs for PPDK polypeptides are organ-specific in both a C(4) and a C(3) plant. Hague et al. (1983 Nucleic Acids Res 11: 4853-4865) proposed that the larger size polypeptide of the in vitro translation polypeptide from maize leaf RNA contains a ;transit sequence' which permits entry into the chloroplasts of a polypeptide synthesized in vivo in maize leaf cell cytoplasm. It appears that in wheat leaves also the transit of synthesized PPDK polypeptide through an intracellular membrane may be required, while such a transit sequence seems not to be required within cells of wheat and maize seeds.
In Vivo Characterization and Therapeutic Efficacy of a C5-specific Inhibitor from the Soft Tick Ornithodoros moubata*

The involvement of complement (C) in inflammatory diseases has driven the search for agents capable of inhibiting dysregulated complement activation. Many of these reagents inhibit the C3 convertases during the early stages of the cascade. However, a drawback of total systemic C inhibition, particularly in longterm treatment of chronic disease, is potentiation of infection and immune complex disease due to an inability to opsonize complexes and foreign cells and to lyse pathogens. Recent identification of a C5-binding protein in the salivary gland of the soft tick Ornithodoros moubata has enabled development of a terminal pathway-specific reagent, OmCI, with potential to ameliorate disease while leaving key physiological processes unaffected. Here we demonstrated that OmCI has broad cross-species activity. When given intravenously to rodents, OmCI totally ablated complement hemolytic activity, which gradually restored as C5 was resynthesized. The circulating half-life of OmCI was 30 h, demonstrating a much slower clearance than other small, biological agents. Using C5-sufficient and C5-deficient mice we showed that prolonged half-life was due to binding to plasma C5. Surface plasmon resonance analysis of C5 binding to OmCI confirmed a high binding affinity with a slow dissociation rate. OmCI was effective in preventing experimental autoimmune myasthenia gravis induced by passive transfer in normal Lewis rats. OmCI ablated clinical disease, reduced C3 and C9 deposition at the neuro-muscular junction, and effected a marked reduction in cellular infiltration at this site. These data offer exciting prospects for targeted treatment of complement-mediated diseases without the detrimental inhibition of the opsonic roles of complement.
Compositional instability of Earth's solid inner core

All models that invoke convection to explain the observed seismic variations in Earth's inner core require unstable inner core stratification. Previous work has assumed that chemical effects are stabilizing and focused on thermal convection, but recent calculations indicate that the thermal conductivity at core temperatures and pressures is so large that the inner core must cool entirely by conduction. We examine partitioning of oxygen, sulfur, and silicon in binary iron alloys and show that inner core growth results in a variable light element concentration with time: oxygen concentration decreases, sulfur concentration decreases initially and increases later, and silicon produces a negligible effect to within the model errors. The result is a net destabilizing concentration gradient. Convective stability is measured by a Rayleigh number, which exceeds the critical value for reasonable estimates of the viscosity and diffusivity. Our results suggest that inner core convection models, including the recently proposed translational mode, can be viable candidates for explaining seismic results if the driving force is compositional.
A PROPOSITION ON THE POPULATION DYNAMICS OF THE STERILE t ALLELES IN THE HOUSE MOUSE

The genetics of the polymorphisms found at the T locus in mice have recently been reviewed by Lewontin and Dunn (1960). Three of the t alleles found in the mouse populations were male sterile and the population dynamics of these genes were investigated by Dunn and Levene (1961) and Lewontin (1962). Dunn and Levene estimated the gene frequency of an allele (t") in a population which had been closed to migration for 15 years. They estimated a frequency of 0.37 with a segregation ratio (m) of 0.84. From a theoretical consideration of equilibrium frequency, assuming random mating and equal fitness of the genotypes, they found the expected frequency to be 0.70, which was far greater than the actual value found in the closed population. The authors concluded that since it was unlikely that the population had not reached equilibrium in 15 years, the discrepancy between the theoretical and actual frequencies might be due to selection. Lewontin (1962) investigated the effect of genetic drift in two sizes of breeding units segregating for the sterile t , using the Monte-Carlo simulation of mice populations in a computer. In the program, m was assumed to be 0.85 and the genotypes were assumed to have equal fitness. In the large breeding units each consisting of 12 males and 12 females the mean frequency of unfixed families after 10 generations of confined breeding was 0.69, a value close to that of the theoretical value of 0.70, The small breeding units of two males and six females each were characterized by a rapid rate of fixation. Of the 221 original populations, by the ninth generation only 59 were still segregating. The mean frequency of the t allele in the unfixed population a t generation 9 was 0.52. A very interesting finding was that after 24 generations, the small populations had
Feed horn coupled bolometer arrays for SPIRE - design, simulations, and measurements

In this paper, we present the design, modeling, and measurements of feed horn coupled large bolometer arrays being developed for the Herschel Space Observatory's Spectral and Photometric Imaging REceiver (SPIRE) instrument. SPIRE has five arrays of feed horn coupled silicon-nitride micromesh "spider-web" bolometers in two instruments, a three-band photometer, and a two-band Fourier transform spectrometer, each covering the 430-GHz-1.5-THz band. The optical coupling efficiency, bandwidth, and crosstalk between adjacent pixels of the arrays were investigated with numerical electromagnetic-field simulators, and prototype arrays were measured extensively in a test facility. The measured results were found to be in good agreement with simulation predictions, and the simulation results were used as a benchmark for the design goals of the instrument.
Flunitrazepam variably alters morphine, buprenorphine, and methadone lethality in the rat

Opiates and substitution products are frequently abused, alone and in association with benzodiazepines. While this combination may result in severe respiratory depression and death, the quantitative relationship remains uncertain. We performed randomized, blinded intravenous median lethal dose (MLD) studies in Sprague–Dawley rats of morphine, buprenorphine, and methadone, alone and in combination with intraperitoneal flunitrazepam pretreatment. We employed the up-and-down method, performed in quadruplicate, comparing time to death following opioid injection. Results are expressed as median of four series (extremes). The MLDs of morphine, buprenorphine, and methadone alone were 64.0 (33.6:79.5), 234.6 (168.6:284.4), and 22.5 (19.3:24.1) mg/kg, respectively, and 60.6 (35.2:88.2), 38.4 (30.6:54.0), and 13.0 (9.7:13.8) mg/kg, respectively, after pretreatment with 40 mg/kg flunitrazepam. Times to death for morphine, buprenorphine, and methadone alone were 2.5 (0.8:24), 0.02 (0.0:24), and 2.0 (0.0:24) hours, respectively, and 13.5 (0.0:144), 24.0 (0.0:120), and 0.0 (0.0:24) hours, respectively, after pretreatment with flunitrazepam 40 mg/kg, ip. Flunitrazepam significantly altered methadone (P=0.02) and buprenorphine (P=0.02) but not morphine lethality (P=0.77). Flunitrazepam significantly prolonged time to death only for buprenorphine (P<0.01). Flunitrazepam–opioid drug–drug interactions are more complex than is generally believed. Mechanistic studies of flunitrazepam–opioid lethal interactions are needed.
Initial Expression of the Common α-Chain in Hypophyseal Pars Tuberalis-Specific Cells in Spontaneous Recrudescent Hamsters.

When exposed to short-day conditions, hamsters and other long-day breeders undergo gonadal regression. With chronic exposure to short days, however, the animals become photorefractory and gonadal recrudescence occurs. The underlying mechanism for this insensitivity is still unknown. There is growing evidence, however, that specific cells of the pituitary pars tuberalis (PT) mediate these photoperiod/nonphotoperiod-dependent changes as a direct or indirect“ Zeitgeber” for the endocrine system. We investigated messenger RNA (mRNA)/protein formation for several hypophyseal hormones (β-TSH, β-LH, PRL, common α-chain) in the pars distalis (PD) and PT of female Djungarian hamsters in long photoperiod (LP) and after 18, 28, and 38 weeks of short photoperiod (SP). As indicated by gonadal and body weight, the hamsters displayed gonadal regression after 18 and 28 weeks of SP; after 38 weeks of SP, all animals showed recrudescence. At 18 and 28 weeks of SP, only PRL mRNA and protein levels were significantly reduced.