Miracle-dz/UniFAR-FTUs huggingface dataset:
Demand Estimation of Fresh Sea Fish with Panel Data Model

The existence of seasonal change factor (arrest and famine) causes an inequilibrium between demand and supply of fresh sea fish in Indonesia. When the famine season causes the production of fish catches to decrease so that fish prices rise, while the other side of demand or consumption is relatively fixed or increased. Research conducted in Indonesia, especially South Sulawesi province aims to estimate the demand of fresh marine fish with selected fish species, indian mackerel, sardinella longiceps , and scads mackerel . The method used by econometric model of data panel with fixed effect method. Based on time dimension used time series data of 1991-2014 with combined data of 3 districts (Barru, Jeneponto, and Sinjai) in South Sulawesi Province. The results of the study found that in general the price of marine fish itself positively and negatively influenced significantly to the demand of fresh sea fish in South Sulawesi. This is because of the taste and preferences of the people of South Sulawesi. Income per capita has a positive effect because of the desire to consume sea fish so that demand always increases. Regional differences have positive and negative effects on the demand for fresh sea fish both in rural and urban areas. Another case the price of chicken eggs have no significant effect. This is because of the factors of consumption behavior and consumer attitudes and culture influence in the decision of the people of South Sulawesi to buy marine fishery products
T-Cell-Mediated Immune Responses in Patients with Cutaneous or Mucosal Leishmaniasis: Long-Term Evaluation after Therapy

ABSTRACT T-cell immune responses in patients with cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML) were studied during the active disease, at the end of therapy, and 1 to 17 years posttherapy (long-term follow-up). Lymphocyte proliferative responses, phenotypic characterization of CD4+ and CD8+Leishmania-reactive T cells, and cytokine production were assayed. Patients with active ML and CL showed higher proportions of CD4+ than CD8+ T cells. In CL, the healing process was associated with a decrease of CD4+ and an increase of CD8+, leading to similar CD4+ and CD8+ proportions. This pattern was only seen in ML after long-term therapy. Long-term follow-up of patients with CL showed a positive CD4+/CD8+ ratio as observed during the active disease, although the percentages of these T cell subsets were significantly lower. Patients with CL did not show significant differences between gamma interferon (IFN-γ) and interleukin-5 (IL-5) production during the period of study. Patients with active ML presented higher IFN-γ and IL-5 levels compared to patients with active CL. IL-4 was only detected during active disease. Patients long term after cure from ML showed increasing production of IFN-γ, significant decrease of IL-5, and no IL-4 production. Two apparently beneficial immunological parameters were detected in tegumentary leishmaniasis: (i) decreasing proportions of CD4+Leishmania-reactive T cells in the absence of IL-4 production associated with cure of CL and ML and (ii) decreasing levels of IL-5 long after cure, better detected in patients with ML. The observed T-cell responses maintained for a long period in healed patients could be relevant for immunoprotection against reinfection and used as a parameter for determining the prognosis of patients and selecting future vaccine preparations.
Trade or Raid: Acadian Settlers and Native Indians Before 1755

The peopling of North America by European settlers often conflicted with the property rights of aboriginals. Trade could, and often did, represent a peaceful and mutually beneficial interaction between these two groups. However, more often than not, raid was preferred over trade. This was not always the case (as exemplified in this paper) for the French settlers of Atlantic Canada, known as Acadians, who enjoyed exceptionally peaceful relations with First Nations. In this paper, I argue that this colony was peripheral in the designs of European governments and was largely stateless and was left to fend for itself. As such, all the costs of raiding were borne by settlers who favored trade over raid for more than a century.
Growth Effects of VAT Evasion and Enforcement

Lower tax revenues have a theoretically mixed effect on growth as they create more disposable income for investment but simultaneously reduce funds for public goods. This study combines firm-level data on tax evasion and enforcement from seventy-nine countries with macroeconomic data to examine the effects of tax enforcement measures and tax revenue shortfall on economic growth. This study finds that while increased enforcement measures reduce growth, high tax revenue collection serves to increase growth. These results suggest that reforms focusing on increasing revenue without resorting to greater enforcement measures are desirable.
Biocompatibility of Supercritical CO2-Treated Titanium Implants in a Rat Model

Supercritical phase CO2 is a promising method for sterilizing implantable devices and tissue grafts. The goal of this study is to evaluate the biocompatibility of titanium implants sterilized by supercritical phase CO2 in a rat subcutaneous implantation model. At 5 weeks post implantation titanium implants sterilized by supercritical phase CO2 produce a soft tissue reaction that is comparable to other methods of sterilization (steam autoclave, ultraviolet light radiation, ethylene oxide gas, and radio-frequency glow-discharge), as indicated by the thickness and density of the foreign body capsule, although there were some differences on the capillary density. Overall the soft tissue response to the implants was similar among all methods of sterilization, indicating supercritical phase CO2 treatment did not compromise the biocompatibility of the titanium implant.
Repeated Mild Traumatic Brain Injury

Mild traumatic brain injury (mTBI) represents a significant public healthcare concern, accounting for the majority of all head injuries. While symptoms are generally transient, some patients go on to experience long-term cognitive impairments and additional mild impacts can result in exacerbated and persisting negative outcomes. To date, studies using a range of experimental models have reported chronic behavioral deficits in the presence of axonal injury and inflammation following repeated mTBI; assessments of oxidative stress and myelin pathology have thus far been limited. However, some models employed induced acute focal damage more suggestive of moderate–severe brain injury and are therefore not relevant to repeated mTBI. Given that the nature of mechanical loading in TBI is implicated in downstream pathophysiological changes, the mechanisms of damage and chronic consequences of single and repeated closed-head mTBI remain to be fully elucidated. This review covers literature on potential mechanisms of damage following repeated mTBI, integrating known mechanisms of pathology underlying moderate–severe TBIs, with recent studies on adult rodent models relevant to direct impact injuries rather than blast-induced damage. Pathology associated with excitotoxicity and cerebral blood flow-metabolism uncoupling, oxidative stress, cell death, blood-brain barrier dysfunction, astrocyte reactivity, microglial activation, diffuse axonal injury, and dysmyelination is discussed, followed by a summary of functional deficits and preclinical assessments of therapeutic strategies. Comprehensive characterization of the pathology underlying delayed and persisting deficits following repeated mTBI is likely to facilitate further development of therapeutic strategies to limit long-term sequelae.
Decision Making Based on Benefit-Costs Analysis: Costs of Preventive Retrofit versus Costs of Repair after Earthquake Hazards

The reduction of seismic risk through the retrofitting of historic buildings serves catastrophe management. In the application of such measures, actors from the spheres of the passive public, experts, as well as active affected people, are involved. The focus of this work is on planning management in the expert area, with a detailed view on the decision space between goals, means, benefits and costs. Buildings of a typology were modelled, and the models translated using a finite elements software with fibre-based modelling of plasticity. The concept of retrofit elements was developed, in order to connect building surveys, construction management, structural simulations, and costs computation based on devices, all related to these retrofit elements. With a view to the general methodology, in order to compare the costs for repairs to buildings after an earthquake with the costs associated with preventive retrofitting of an undamaged building, several cases were considered: damages on a non-retrofitted building, damages on retrofitted building, retrofitting on an undamaged building, retrofitting on a pre-damaged building, and the subsequent damages in an earthquake for the last two. The innovative part of this research lies in the use of the tension-elongation approach to models of building size. Such an analysis allows not only the description of ways of collapsing and the setting of limit states, but also exactly the specific amount and position of the structural members which fail in certain performance criteria. This type of results can form the basis for interdisciplinary studies, such as economic efficiency studies. The method was applied for early reinforced concrete buildings, which are common in Bucharest, Romania, in a deterministic method which takes into account recorded earthquakes. In conclusion, depending on the size of an earthquake, the timing and extent of the retrofit to be applied differ, if we are to obtain cost savings in preventive retrofitting compared to post-earthquake repair. This is presented through a range of costs curves.
Media coverage of the “refugee crisis”: A cross-European perspective.

Media have played an important role in framing the public debate on the “refugee crisis” that peaked in autumn of 2015. This report examines the narratives developed by print media in eight European countries and how they contributed to the public perception of the “crisis”, shifting from careful tolerance over the summer, to an outpouring of solidarity and humanitarianism in September 2015, and to a securitisation of the debate and a narrative of fear in November 2015.
The relation between prototypical processes and psychological distress in psychodynamic therapy of five inpatients with borderline personality disorder.

UNLABELLED Five inpatients with borderline personality disorder (BPD) participated in 6 months of three times per week psychodynamic therapy (PDT). Patients completed a measure of psychological distress every week. A total of 127 sessions were audiotaped and coded using the psychotherapy process Q-set (PQS) and correlated with PQS prototypes of five treatment models-PDT, cognitive-behaviour therapy (CBT), interpersonal therapy, transference focused psychotherapy and dialectical behaviour therapy. Prototypical CBT process was most prevalent in three of the five PDT-labelled treatments. Prototypical PDT process significantly decreased over time in three of the five treatments. Prototypical process correlations with time were inversely proportional to prototypical process correlations with distress levels. In a multiple regression model that included all five prototypical process correlations across these three treatments, CBT and transference focused psychotherapy predicted distress reduction, whereas PDT predicted increases in distress. PQS items most negatively correlated with distress included the therapist's emphasis on feelings, empathic attunement and control over the interaction. Discussion of dreams or fantasies and therapist aloofness were most positively correlated with distress. An effective PDT treatment model for severely disturbed BPD inpatients requires technical flexibility to supplement CBT processes such as control over the interaction that can structure intense interpersonal dysregulation and stabilize distress. KEY PRACTITIONER MESSAGE Practitioners and their patients sense which prototypical processes to increase or decrease over time to reduce patients' distress. An effective PDT treatment model for severely disturbed BPD patients needs to integrate and encourage the emergence of empathically attuned interactions in the context of a highly structured therapy experience. Practitioners need to be flexible enough to change intervention strategies when they seem to be increasing distress in severely disturbed BPD patients.
Up‐Regulation of Cytochrome P450 1A2, 2C9, and 2E1 in Chronic Pancreatitis

The oxidative metabolism of xenobiotics is effected mainly by cytochrome P450 enzymes (CYP), which are expressed as a family of genetically related enzymes primarily in hepatocytes. The pancreas is among the extrahepatic tissues expressing CYP, and it has been suggested that intermediates generated by them might be of pathogenetic significance for diseases of the pancreas such as chronic pancreatitis. We studied 10 surgical resection specimens by immunohistochemistry with polyclonal antibodies against recombinant human CYP 1A1, 1A2, 2C9, 2E1, and 3A and used tissues from 11 normal pancreata as controls. In addition, we assayed microsomal preparations for their capacity to metabolize verapamil. In normal pancreata weak to moderate expression of all enzymes was demonstrated immunohistochemically in up to 50% of duct epithelia, acinar cells, and islet cells. In contrast, in chronic pancreatitis an up-regulation was observed, with immunohistochemical positivity in some cases in up to 100% of duct epithelia and acinar cells. The oxidative capacity of microsomal preparations from chronic pancreatitis was higher than that of preparations obtained from control tissues; compared to liver microsomes, however, it was low. The up-regulation of CYP may have pathogenetic significance for chronic pancreatitis. Yet considering the pancreas' capacity for conjugation reactions, conceivably low levels of reactive intermediates could effectively undergo inactivation.
Characterisation of Vibrio parahaemolyticus isolated from fish in Kenya.

BACKGROUND Acute gastroenteritis associated with fish has been reported since 1951 but is gaining importance with increase in fish consumption in Kenya. The causative agent is Vibrio parahaemolyticus. The importance of this organism is increasing due to the rise in the incidence of outbreaks of food poisoning related to it. OBJECTIVE To isolate and characterise local strains of Vibrio parahaemolyticus from sea and fresh-water fish. DESIGN A prospective study. SETTING Three lakes, a river, a dam and the Kenyan coastline. SUBJECTS Water and fish samples collected from the study sites. MAIN OUTCOME MEASURES Isolation of Vibrio parahaemolyticus on glucose-salt-teepol broth (GTSB), and triphenyltetrazolium chloride soya tryptone (TSAT) and several biochemical media, testing the pathogenicity for the isolates by Kanagawa phenomenon and testing the plasmids profiles, coagglutination sensitivity to antimicrobial substance using standard methods. RESULTS Twenty nine isolates (4%) were obtained from a total of 666 samples screened, twenty seven of which were isolated from 62 coastal samples. They were Kanagawa negative although their plasmid profiles and sensitivity to antimicrobials varied. CONCLUSION There is need to recognise V. parahaemolyticus as a potential problem due to the increase in consumption of fish as an alternative source of protein.
Stages and trigger factors in the development of academic spin-offs: An explorative study in southern Italy

The purpose of this paper is to combine studies that describe the spin-off creation process with studies that analyze spin-off determinants to understand the phenomenon of spin-off development. ,This paper proposes a theoretical framework to improve our understanding of academic spin-off development in southern Italy. Following a systematic combining approach, the framework is constructed by iteratively matching the concepts derived by the literature on spin-off processes and spin-off determinants with the empirical findings obtained through a case study of 19 spin-offs in southern Italy. ,The combination of empirical results and literature analysis helps us to identify a general model for spin-off creation that could be particularly useful to explain the criticalities of their development. ,This paper provides implications for policy-makers in southern Italy regarding factors for which intervention would support the creation of new spin-offs. This study also provides useful implications for policy-makers in other contexts, such as areas that may or may not be at a disadvantage. ,The resulting framework represents an original contribution to the literature because it: links two aspects – the stages of spin-off creation and determinants of spin-off development – which are often considered separately in existing studies; explores factors that either impede or facilitate the different stages of spin-off development; provides a series of findings that can be successively tested in other studies; and sheds more light on the context of southern Italy, which has been investigated in only a limited number of previous studies.
Development and Application of Real-Time PCR Assays for Quantification of Genes Encoding Tetracycline Resistance

ABSTRACT We report here the development, validation, and use of three real-time PCR assays to quantify the abundance of the following three groups of tetracycline resistance genes: tet(A) and tet(C); tet(G); and tet genes encoding ribosomal protection proteins, including tet(M), tet(O), tetB(P), tet(Q), tet(S), tet(T), and tet(W). The assays were validated using known numbers of sample-derived tet gene templates added to microbiome DNA. These assays are both precise and accurate over at least 6 log tet gene copies. New tet gene variants were also identified from cloned tet amplicons as part of this study. The utility of these real-time PCR assays was demonstrated by quantifying the three tet gene groups present in bovine and swine manures, composts of swine manure, lagoons of hog house effluent, and samples from an Ekokan upflow biofilter system treating hog house effluent. The bovine manures were found to contain fewer copies of all three groups of tet genes than the swine manures. The composts of swine manures had substantially reduced tet gene abundance (up to 6 log), while lagoon storage or the upflow biofilter had little effect on tet gene abundance. These results suggest that the method of manure storage and treatment may have a substantial impact on the persistence and dissemination of tet genes in agricultural environments. These real-time PCR assays provide rapid, quantitative, cultivation-independent measurements of 10 major classes of tet genes, which should be useful for ecological studies of antibiotic resistance.
Small nuclear ribonucleoprotein polypeptide N quantitative methylation analysis in infants with central hypotonia

Abstract Central hypotonic is one of the most difficult issues in neurology, ruling out neurogenetic syndromic causes is critical, Prader-Willi syndrome (PWS) it is the most frequent genetic syndrome, it is caused by the loss of expression of the paternal allele in a group of imprinted genes within 15q11-q13, and is characterized by severe prenatal and postnatal hypotonia. SNURF-SNRPN gene methylation detects 99% of the cases but fluorescent in situ hybridization (FISH) analysis is necessary to confirm chromosome microdeletions. The advantage of SNRP-quantitative strategy of methylated alleles is that it makes it possible to make the diagnosis and identify deletions and mosaicism in one reaction. In infants clinical diagnosis is difficult. It has been proposed that around 40% of hypotonic patients have PWS but an accurate percentage has not been established. Twenty-four central hypotonic infants were studied by this molecular strategy, showing 41.5% with the disease. This molecular approach also permitted calculation of gene dosage and detection of those cases with microdeletion.
“They Kind of Rely on the Library”: School Librarians Serving LGBT Students

This research examines school librarians’ perspectives on collecting LGBT materials. Based on qualitative interviews with thirty-one school librarians, this project found generally strong support for collecting LGBT materials. School librarians discussed serving their communities, having resources for all students, and meeting the needs of diverse students. In addition, they shared several ways that school libraries can counter bullying: creating a bully-free zone in the library, collecting LGBT and anti-bullying materials, collaborating with guidance counselors and teachers, suggesting particular books for certain students, being a supporter of students, and positioning the school library as a safe space.
Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta‐analysis of the management outcome studies

Summary. Background: Multiple‐detectors computed tomographic pulmonary angiography (CTPA) has a higher sensitivity for pulmonary embolism (PE) within the subsegmental pulmonary arteries as compared with single‐detector CTPA. Multiple‐detectors CTPA might increase the rate of subsegmental PE diagnosis. The clinical significance of subsegmental PE is unknown. We sought to summarize the proportion of subsegmental PE diagnosed with single‐ and multiple‐detectors CTPA and assess the safety of diagnostic strategies based on single‐ or multiple‐detectors CTPA to exclude PE. Patients and methods: A systematic literature search strategy was conducted using MEDLINE, EMBASE and the Cochrane Register of Controlled Trials. We selected 22 articles (20 prospective cohort studies and two randomized controlled trials) that included patients with suspected PE who underwent a CTPA and reported the rate of subsegmental PE. Two reviewers independently extracted data onto standardized forms. Results: The rate of subsegmental PE diagnosis was 4.7% [95% confidence interval (CI): 2.5–7.6] and 9.4 (95% CI: 5.5–14.2) in patients that underwent a single‐ and multiple‐detectors CTPA, respectively. The 3‐month thromboembolic risks in patients with suspected PE and who were left untreated based on a diagnostic algorithm including a negative CTPA was 0.9% (95% CI: 0.4–1.4) and 1.1% (95% CI: 0.7–1.4) for single‐ and multiple‐detectors CTPA, respectively. Conclusion: Multiple‐detectors CTPA seems to increase the proportion of patients diagnosed with subsegmental PE without lowering the 3‐month risk of thromboembolism suggesting that subsegmental PE may not be clinically relevant.
The ‘mobile proletariat’: the production of proletariat labor on a Soviet construction site

Abstract This article discusses the Soviet conceptualization of labor and its importance for state building and modernization in the USSR. The article helps to explicate the ways in which labor migration was an integral part of the socialist development project in regions such as Tajikistan. Through the case study of the Nurek Dam, it considers the processes by which the Soviet proletariat was produced through work, mobility, and socialization. It ultimately presents an argument about the mutual constitution of the Soviet state and Soviet citizens, whose labor embodied the state’s idealized ‘mobile proletariat. ’ Finally, it also outlines what the development of the ‘mobile proletariat’ and other ideals of labor came to mean for groups of peripheral subjects in the USSR – as well as what such boundaries may say about the limits of the Soviet modernization project in practice.