Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of vaginal and cesarean section delivery for fetuses in breech presentation

Abstract Objectives: Our purpose was to evaluate the perinatal mortality and morbidity of deliveries with fetuses presenting by the breech comparing outcomes of two groups according to mode of delivery: vaginal and cesarean section. Results: Of 756 fetuses studied, 271 were delivered vaginally and 485 by cesarean section. In infants weighing ≥ 1500 grams, “further corrected” mortality and morbidity rates were low and similar for both delivery routes: one neonatal death (NNM) in each. Among very low birth weight (VLBW) infants (< 1500 grams) the “further corrected” mortality rate was higher in the vaginal group: 57.4%, and 18.0% in abdominal deliveries (odds ratio [OR] = 6.1, 95% CI: 3.1 to 12.1). Likewise, rate of depression at five minutes were higher in the vaginal group (p < 0.001). However, the average fetal weight among the vaginal deliveries VLBW (787 grams) was 250 grams less than in the cesarean section group (1040 grams). After adjustment for fetal weight, gestational age, and other prognostic variables the odds ratio for neonatal death was no longer statistically significant (adjusted OR = 2.1, 95% CI: 0.9 to 5.2, p = 0.105). Comparison of planned vaginal delivery with elective cesarean section yielded smaller differences (adjusted OR for neonatal death = 1.3, 95% CI: 0.6 to 2.9, p = 0.525). Conclusion: The poor perinatal outcomes of breech delivered infants are due primarily to VLBW, congenital malformations, and premature labor. Although abdominal delivery had a lower NNM rate than vaginal delivery, the difference was not significant after adjustment for confounding factors. The results confirm the findings of a previously analyzed similar series delivered at our institution between 1980 and 1987. They suggest that, with appropriate technique, abdominal delivery is not mandatory in breech presentation.
Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing.

OBJECTIVE The purpose of this study was to determine the effect of docosahexaenoic acid supplementation on plasma phospholipid docosahexaenoic acid content and indices of depression and information processing for women who breast-feed. STUDY DESIGN Mothers who planned to breast-feed their infants were assigned randomly in a double-masked fashion to receive either docosahexaenoic acid (approximately 200 mg/d) or placebo for the first 4 months after the delivery. Major outcome variables included plasma phospholipid fatty acid patterns and scores on a self-rating questionnaire of current depression symptoms. A structured clinical interview of depression, scores on another self-rating questionnaire of depression symptoms, and a laboratory measure of information processing were obtained in subgroups of the total population. RESULTS Plasma phospholipid contents of docosahexaenoic acid at baseline were 3.15 +/- 0.78 and 3.31 +/- 0.70 (mg/dL of total fatty acids) in the docosahexaenoic acid and placebo groups, respectively. After 4 months, the plasma phospholipid docosahexaenoic acid content of the docosahexaenoic acid group was 8% higher (3.40 +/- 0.97 mg/dL), whereas that of the placebo group was 31% lower (2.27 +/- 0.87 mg/dL). Despite the higher plasma phospholipid docosahexaenoic acid content of the supplemented group after 4 months, there was no difference between groups in either self-rating or diagnostic measures of depression; information processing scores of the two groups also did not differ. CONCLUSION Docosahexaenoic acid supplementation ( approximately 200 mg/d) for 4 months after the delivery prevented the usual decline in plasma phospholipid docosahexaenoic acid content of women who breastfeed but did not influence self-ratings of depression, diagnostic measures of depression, or information processing.
Non‐native interactions, effective contact order, and protein folding: A mutational investigation with the energetically frustrated hydrophobic model

By Monte Carlo simulations, we explored the effect of single mutations on the thermodynamics and kinetics of the folding of a two‐dimensional, energetically frustrated, hydrophobic protein model. Φ‐Value analysis, corroborated by simulations beginning from given sets of judiciously chosen initial contacts, suggests that the transition state of the model consists of a limited region of the native structure, that is, a folding nucleus. It seems that the most important contacts in the transition state (large and positive Φ) are not the ones with the highest contact order, because in this case the entropic cost of their formation would be too high, but exactly the ones that decrease the entropic cost of difficult contacts, reducing their effective contact order. Mutations of internal monomers involved in high‐order contacts were actually the ones resulting in the fastest kinetics (and Φ < 0), indicating they tend to make low order, non‐native contacts of low entropic cost that stabilize the unfolded state with respect to the transition state. Folding acceleration by other non‐native interactions was also observed and a simple general mechanism is proposed according to which non‐native contacts can act indirectly over the folding nucleus, “chelating” out potentially harmful contacts. The polymer graph of our model, which facilitates the visualization of effective contact orders, successfully suggests the relative kinetic importance of different contacts and is reasonably consistent with analogous graphs for the well characterized family of SH3 domains. Proteins 2002;49:167–180. © 2002 Wiley‐Liss, Inc.
Social Support as a Predictor of Disability Pension: The Finnish Health 2000 Study

Objective: Social support at work and in private life was examined as a predictor of disability pension in the population-based Finnish Health 2000 study. Methods: Social support was measured in a nationally representative sample comprising of 3414 employees aged 30 to 64 years. Disability pensions extracted from the registers of the Finnish Centre for Pensions were followed up across 6 years. Results: Low social support from supervisors was associated with disability pension with an odds ratio of 1.70 (95% confidence interval, 1.21 to 2.38) when adjusted with sociodemographic and health behavior variables. After adjustment for baseline perceived health, the associations between supervisor support and disability pension strongly attenuated. Conclusions: Low social support from supervisors predicts forthcoming work disability but the relationship is affected by self-reported nonoptimal health at baseline.
Evaluation of the psychometric properties of the Pediatric Parenting Stress Inventory (PPSI).

OBJECTIVE This work evaluated the psychometric properties of the Pediatric Parenting Stress Inventory (PPSI), a new measure of problems and distress experienced by parents of children with chronic illnesses. METHOD This secondary data analysis used baseline data from 1 sample of English-, Spanish-, and Hebrew-speaking mothers of children recently diagnosed with cancer (n = 449) and 1 sample of English- and Spanish-speaking mothers of children recently diagnosed with cancer (n = 399) who participated in 2 problem-solving skills training interventions. The PPSI was administered at baseline with other measures of maternal distress. Factor structure was evaluated using exploratory factor analysis (EFA) on the first sample and confirmatory factor analysis (CFA) on both samples. Internal consistency was evaluated using Cronbach's alpha. Construct validity was assessed via Spearman correlations with measures of maternal distress. RESULTS EFA resulted in a stable four-factor solution with 35 items. CFA indicated that the four-factor solution demonstrated reasonable fit in both samples. Internal consistency of the subscales and full scale was adequate to excellent. Construct validity was supported by moderate to strong correlations with measures of maternal distress, depression, and posttraumatic stress symptoms. CONCLUSIONS The PPSI demonstrated good psychometric properties in assessing current problems and distress experienced by mothers of children newly diagnosed with cancer. This tool may be used to identify individualized targets for intervention in families of children with cancer. Future studies could evaluate the utility and psychometrics of the PPSI with other pediatric populations.
Heterogeneity of Multiple Sclerosis White Matter Lesions Detected With T2*‐Weighted Imaging at 7.0 Tesla

Postmortem studies in multiple sclerosis (MS) indicate that in some white matter lesions (WM‐Ls), iron is detectable with T2*‐weighted (T2*‐w), and its reciprocal R2* relaxation rate, magnetic resonance imaging (MRI) at 7.0 Tesla (7T). This iron appears as a hyperintense rim in R2* images surrounding a hypointense core. We describe how this observation relates to clinical/radiological characteristics of patients, in vivo.
An Investigation of Responsibility and Learner Autonomy in a Sino-British EAP Program in China

Learner autonomy has become a universally acknowledged benign notion and exercised in all levels of education, especially in tertiary settings, although some doubts have been cast on its suitability in teacher-dependent contexts. Learner autonomy entails capacity to take on responsibility for ones’ own learning. This study aims to investigate students’ perceptions of their own responsibility and their teachers’, and then evaluate students’ autonomy in English learning in an EAP curriculum in a Sino-British university in China. To these aims, a 30-item questionnaire was compiled to administer to 276 year 1 and year 2 students, and T-test and one-way ANOVA were used to analyze the data. It was found that students in this Sino-British context perceived themselves to assume more responsibility for their own learning compared to their Chinese counterparts, but teachers had more responsibility to stimulate their learning inside the classroom. The degree of autonomy increased accordingly by students’ language proficiency level. Female students assumed more responsibility than male students while the latter were more autonomous than the former. Although students had a good understanding of course aims, they had low awareness of setting goals and plans. These findings have implications for promoting autonomy in tertiary settings in this specific context, as well as in other tertiary settings.
Lack of long-term fMRI differences after multiple sports-related concussions

Introduction: Mild traumatic brain injury (mTBI) or concussion has been acutely associated with several cognitive symptoms, including deficits in response inhibition, working memory and motor performance. The pervasiveness of these cognitive symptoms has been more controversial. The effects of multiple concussions on neuropsychological functioning and brain activation following at least 6-months post-mTBI were examined. Methods: Twenty right-handed male athletes with a history of at least two concussions and 20 age/pre-morbid IQ/athletic-experience matched controls underwent neuropsychological assessment and fMRI scanning where they performed versions of a colour-word Stroop interference task, an operation-span working memory task and a finger-tapping task. Results: The Attention index score on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was lower for the concussion group, but only at liberal statistical threshold. Total RBANS score approached statistical significance. Reaction time during neurobehavioural tasks was similar across groups, but accuracy was reduced in the concussed group on the working memory task. Despite expected activation patterns within each group, there were no group differences in neural activation on any functional tasks using either whole-brain or ROI-specific analyses at liberal statistical thresholds. Conclusion: There were minimal differences between the two closely matched groups. Results point to the relative plasticity of younger adults’ cognitive abilities following concussion.
Microleakage evaluation of a new low-shrinkage composite restorative material.

PURPOSE This study compared the microleakage of an experimental low-shrinkage resin composite (Hermes), a nanofilled resin composite material (Filtek Supreme) and a hybrid resin composite (Tetric Ceram) using a dye penetration method. METHODS AND MATERIALS Class I cavities prepared in 60 human molars were randomly divided into 3 groups according to the restorative material used. The preparations were restored using a bulk or an incremental technique. Half of the specimens from each group were subjected to 200,000 cycles of loading at 50 N, while the other half were stored in distilled water for 24 hours at 37 degrees C. All specimens were immersed in 1% methylene blue (pH = 7.0) for 24 hours and sectioned into 3 slabs. The margins were evaluated for microleakage using an ordinal scoring system (0-4) under a stereomicroscope at 40x magnification. Data were subjected to the non-parametric Kruskal-Wallis analysis of variance and Mann-Whitney test (p<0.05). Data were expressed as median leakage scores and mean ranks. RESULTS All of the restorative systems had microleakage, regardless of the insertion technique and mechanical load cycling. Incremental placement significantly reduced microleakage as compared to the bulk technique, regardless of the restorative system used. Load cycling significantly affected incrementally placed restorations, except for the Hermes system.
Association of mesenteric portovenographic findings with outcome in cats receiving surgical treatment for single congenital portosystemic shunts.

OBJECTIVE To determine whether hepatic portal vascularity assessed via intraoperative mesenteric portovenography (IMP) is related to outcome in cats undergoing surgical attenuation of a congenital portosystemic shunt (CPSS). DESIGN Retrospective case series. ANIMALS 25 cats, each with 1 CPSS, in which IMP was performed before and after temporary complete occlusion of the shunting vessel to provide complete (n=9) or partial (16) shunt attenuation. PROCEDURES Medical records were reviewed for signalment, clinical history, postoperative complications, clinical outcome, and results of bile acids stimulation testing. Portovenograms obtained before and after shunt occlusion were graded to determine whether degree of intrahepatic portal branching was correlated with degree of shunt attenuation, clinical or biochemical factors, postoperative complications, or outcome. In 12 of the 16 cats that had partial CPSS attenuation, procedures were later repeated to achieve complete (n=9) and additional partial (1) CPSS attenuation. RESULTS Degree of opacification of the intrahepatic portal vessels increased significantly (higher portovenogram grade) after CPSS attenuation. The median portovenogram grade assigned after temporary shunt occlusion at the first surgery was significantly higher in cats that did not have postattenuation neurologic complications or neurologic signs at follow-up than in cats that did. It was also higher in cats that had a better clinical response to surgery versus those that had a poor response and in cats with reduced preprandial and postprandial serum bile acids concentrations at follow-up versus those that did not. CONCLUSIONS AND CLINICAL RELEVANCE IMP may be used to help predict complications and outcome following surgical treatment of CPSS in cats.
The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and Is a Critical Regulator of Gene Expression

ABSTRACT The candidate tumor suppressor BAP1 is a deubiquitinating enzyme (DUB) involved in the regulation of cell proliferation, although the molecular mechanisms governing its function remain poorly defined. BAP1 was recently shown to interact with and deubiquitinate the transcriptional regulator host cell factor 1 (HCF-1). Here we show that BAP1 assembles multiprotein complexes containing numerous transcription factors and cofactors, including HCF-1 and the transcription factor Yin Yang 1 (YY1). Through its coiled-coil motif, BAP1 directly interacts with the zinc fingers of YY1. Moreover, HCF-1 interacts with the middle region of YY1 encompassing the glycine-lysine-rich domain and is essential for the formation of a ternary complex with YY1 and BAP1 in vivo. BAP1 activates transcription in an enzymatic-activity-dependent manner and regulates the expression of a variety of genes involved in numerous cellular processes. We further show that BAP1 and HCF-1 are recruited by YY1 to the promoter of the cox7c gene, which encodes a mitochondrial protein used here as a model of BAP1-activated gene expression. Our findings (i) establish a direct link between BAP1 and the transcriptional control of genes regulating cell growth and proliferation and (ii) shed light on a novel mechanism of transcription regulation involving ubiquitin signaling.
Proteinuria is associated with elevated tricuspid regurgitant jet velocity in children with sickle cell disease

Sickle cell disease (SCD) affects multiple organ systems. Complications of SCD such as pulmonary hypertension (PHT) and sickle cell nephropathy (SCN) are associated with an increased mortality. Both PHT and SCN have some common risk factors. In adults, PHT has been found to be associated with albuminuria, a manifestation of SCN. There is no data on this association in children. We conducted a study to determine if elevated pulmonary artery systolic pressures estimated on echocardiogram was associated with proteinuria in children with SCD.
Extended Adjuvant Chemotherapy in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) represents a heterogeneous breast cancer subtype with a poor prognosis. The optimal adjuvant chemotherapy regimen is still unknown. Although numerous large randomized trials have established the benefit of adjuvant anthracyclines and/or taxanes in TNBC, there is no preferred regimen for these patients. There is currently no guideline. Moreover, without knowing the optimal treatment backbone, it will not be possible to evaluate whether adding agents such as platinum or other novel therapies is beneficial for TNBC patients. Furthermore, the best duration of adjuvant treatment in TNBC is still unknown. This review will focus on results of clinical trials that analyzed the benefits of extending the duration of adjuvant treatment in TNBCs with maintenance treatments. We will further discuss promising results in favor of other new agents including capecitabine, metronomic treatment, and biological drugs.
Effects of Co-Channel Interference on the Error Probability Performance of Multi-Hop Relaying Networks

We introduce closed-form lower bounds for the performance of multi-hop wireless networks with non-regenerative relays over Rayleigh fading channels in the presence of co-channel interference. The analysis assumes an arbitrary number of independent and identically distributed Rayleigh interferers. Novel closed-form expressions are obtained for the probability density function (PDF) and cumulative distribution function of the upper bounded end-to-end signal-to-interference-plus-noise ratio (SINR) at the destination node. These results are then used to study the average error probability. Furthermore, an approximate expression for the PDF of the instantaneous end-to-end SINR is derived, based on which general asymptotic expression for the error probability is presented and discussed. Moreover, analytical comparison of the error probability achieved by amplify-and-forward and decode-and-forward multi-hop transmissions is provided. Using these expressions, the effect of co-channel interference on system performance is investigated.
A review of the literature on the selegiline transdermal system: an effective and well-tolerated monoamine oxidase inhibitor for the treatment of depression.

OBJECTIVE To provide a narrative review of the properties of the selegiline transdermal system (STS) for the treatment of depression and its subtypes. BACKGROUND Monoamine oxidase inhibitors (MAOIs) once represented the mainstay of therapy for the treatment of major depressive disorder (MDD). However, despite their efficacy, these agents fell from favor due to the risk of acute hypertensive reactions following ingestion of foods containing high concentrations of tyramine. Recent efforts to develop MAOIs that overcome these limitations have resulted in the introduction of the first transdermal formulation of the MAOI selegiline for the treatment of MDD. DATA SOURCES A PubMed literature search was conducted in January 2007 using the keyword selegiline transdermal system. STUDY SELECTION Articles retrieved were reviewed and selected for inclusion based on their being randomized, double-blind, placebo-controlled studies that appeared between the years 2000 and 2007 and examined efficacy, safety, and tolerability data from clinical trials of patients with MDD who were treated with the STS. Four articles, including 3 acute trials and 1 long-term prevention of relapse trial, were included in this review based on these criteria. CONCLUSIONS The selegiline transdermal system provides several advantages compared to orally administered MAOIs, including minimal interaction with dietary tyramine and prolonged exposure to the parent compound, while offering a favorable side effect profile. As a result, treatment at the lowest effective dose of 6 mg/24 hours can be administered without the need for dietary modifications.
Without coal in the age of steam and dams in the age of electricity: an explanation for the failure of Portugal to industrialize before the Second World War

We provide a natural resource explanation for the divergence of the Portuguese economy relative to other European countries before the Second World War, based on a considerable body of contemporary sources. First, we demonstrate that a lack of domestic resources meant that Portugal experienced limited and unbalanced growth during the age of steam. Imports of coal were prohibitively expensive for inland areas, which failed to industrialize. Coastal areas developed through steam, but were constrained by limited demand from the interior. Second, we show that after the First World War, when other coal-poor countries turned to hydro-power, Portugal relied on coal-based thermal-power, creating a vicious circle of high energy prices and labor-intensive industrialization. We argue that this was the result of (i) water resources which were relatively expensive to exploit; and (ii) path-dependency, whereby the failure to develop earlier meant that there was a lack of capital and demand from industry.