Miracle-dz/UniFAR-FTUs huggingface dataset:
Matched filtering of gravitational waves from inspiraling compact binaries: Computational cost and template placement

We estimate the number of templates, computational power, and storage required for a one-step matched filtering search for gravitational waves from inspiraling compact binaries. Our estimates for the one-step search strategy should serve as benchmarks for the evaluation of more sophisticated strategies such as hierarchical searches. We use a discrete family of two-parameter wave form templates based on the second post-Newtonian approximation for binaries composed of nonspinning compact bodies in circular orbits. We present estimates for all of the large- and mid-scale interferometers now under construction: LIGO ~three configurations! , VIRGO, GEO600, and TAMA. To search for binaries with components more massive than mmin50.2M( while losing no more than 10% of events due to coarseness of template spacing, the initial LIGO interferometers will require about 1.0310 11 flops ~floating point operations per second ! for data analysis to keep up with data acquisition. This is several times higher than estimated in previous work by Owen, in part because of the improved family of templates and in part because we use more realistic ~higher! sampling rates. Enhanced LIGO, GEO600, and TAMA will require computational power similar to initial LIGO. Advanced LIGO will require 7.8310 11 flops, and VIRGO will require 4.8 310 12 flops to take full advantage of its broad target noise spectrum. If the templates are stored rather than generated as needed, storage requirements range from 1.5 310 11 real numbers for TAMA to 6.2310 14 for VIRGO. The computational power required scales roughly as mmin8/3 and the storage as mmin13/3 . Since these scalings are perturbed by the curvature of the parameter space at second post-Newtonian order, we also provide estimates for a search with mmin51M( . Finally, we sketch and discuss an algorithm for placing the templates in the parameter space. @S0556-2821~99! 05214-5#
Frequency , perceptions and complications of sexual activity during pregnancy among a group of Nigerian women

Background: Hormonal, emotional and physical changes that occur in pregnancy as well as cultural influences in our society may impac practices and perceptions regarding sexual intercourse during pregnancy. Aim: This study was undertaken to evaluate the frequency, practices, perceptions and safety of sexual intercourse during pregnancy among pregnant women in Jos, Nigeria. Materials and methods: This was a cross over a 6-month period. They anonymously completed self sexual activities during pregnancy. Data collected included coital frequency, perceptions and concerns of sexual intercourse during pregnancy, its benefits and problems encountered. Statistical analysis was done using SPSS version 16 was used to ascertain associations between categorical variables. P < 0.05 was considered significant. Results: All women were sexually active throughout pregnancy but with overall decrease coital frequency compared to the pre side, man on top and rear positions. 0.54 – 2.65), primigravidity (P = 0.52, OR 0.80, 95% CI 0.40 95% CI 0.43 – 1.62) had no influence on coital frequency. More than 90.0% of them opined that sex 2, Issue 6, June, 2015. , Okoye Florence Ngozi 2 , Bulus Ayuba Dabu ecology, College of Medicine and Health Sciences, Bingham ecology, Plateau State Specialist Hospital, Jos, Nigeria
Changes of autonomic information flow due to idiopathic dilated cardiomyopathy

Risk stratification of patients with idiopathic dilated cardiomyopathy (IDC) is an epidemiologically relevant question. But the results based on conventional heart rate variability (HRV) analysis are still unsatisfactory. The adjustments within the cardiovascular system incorporate nonlinear and complex mechanisms of information exchange which may have additional prognostic value. It is an objective of the present work to evaluate the prognostic value of autonomic information flow (AIF) measures in IDC patients compared to conventional HRV measures in a first explorative study. Holter recordings of 32 patients with idiopathic dilated cardiomyopathy (IDC) and 12 normal subjects (NRM) were analyzed. The IDC patients consisted of two groups: 10 high risk (HR) patients, after aborted sudden cardiac death (SCD); 22 low risk (LR) patients, without SCD. Sensitivity, specificity, positive predictive value, negative predictive value and ROC characteristics of a comprehensive set of AIF measures, organized according to the conventional HRV standards, and conventional HRV measures were investigated. The significant risk predictors were evaluated by Spearman's rank correlation. While the only traditional HRV measure discriminating IDC patients from NRM was ln(LF) most of the AIF measures had a discriminatory value. Concerning the prognosis of the IDC patients by conventional HRV we found that SDNN and all frequency band measures (lnHF, lnLF, lnVLF) significantly discriminated HR from LR. Among the AIF measures the time shift related peak decay (PDdHF) reflecting the HF band information flow had a prognostic value. PDdHF was identified as a promising candidate which might improve the predictive value of traditional HRV analysis, predominantly represented by SDNN. A subsequent comprehensive clinical study is necessary to validate this hypothesis.
Multicentric Study of Seroprevalence of Borrelia Burgdorferi and Anaplasma Phagocytophila in High-Risk Groups in Regions of Central and Southern Italy

The aim of this study was to evaluate the seroprevalence of B. burgdorferi and A. phagocytophila in populations of workers from 4 Italian regions, known to be exposed to tick bites. A total of 712 serum samples collected were divided as follows: 387 samples were obtained from workers at risk for tick bites and 325 from individuals that were not considered to be at risk of ticks bites and served as the control group. Antibodies against B. burgdorferi were found in 29 (7.5%) of the 387 risk workers and in 4 (1.2%) of the 325 control group. Antibodies reactive with the HGE agent were found in 22 (5.7%) of the 387 risk workers and in 3 (0.9%) of the 325 control group. Antibodies to both B. burgdorferi and A. phagocytophila were found in 1.6% of the forestry workers confirming the possibility of coinfection or concurrent infection. The present finding show significant differences between seroprevalence of the risk workers and that of the people with no risk for tick exposure.
Base treatment corrects defects due to misfolding of mutant cystic fibrosis transmembrane conductance regulator.

BACKGROUND & AIMS The most common form of the disease-causing cystic fibrosis transmembrane conductance regulator mutation, DeltaF508, leads to a misfolded protein that undergoes endoplasmic reticulum-associated degradation. Retrieval of misfolded protein from the cis-Golgi or pre-Golgi intermediate compartment is a critical factor in endoplasmic reticulum retention and degradation of DeltaF508 protein. Therefore, the inhibition of retrograde Golgi-to-endoplasmic reticulum traffic by the alkalinization of Golgi lumen may permit functional DeltaF508 protein to reach the cell surface. METHODS Functional and biochemical effects of alkaline treatment on misfolded cystic fibrosis transmembrane conductance regulator-induced defects were measured in CFPAC-1 cells, which endogenously express DeltaF508 cystic fibrosis transmembrane conductance regulator, and in CHO cells, which heterologously express DeltaF508 cystic fibrosis transmembrane conductance regulator. The animal survival rate and the functional expression of cystic fibrosis transmembrane conductance regulator proteins were analyzed in homozygous DeltaF508 mice after chronic treatment with weak base NaHCO3. RESULTS In CFPAC-1 and CHO cells, intracellular alkalization by reducing carbon dioxide concentrations in a carbon dioxide incubation chamber or intra-Golgi alkalization by bafilomycin A1 treatment increased the membrane expression of DeltaF508 protein and cystic fibrosis transmembrane conductance regulator-dependent anion transport. Notably, chronic administration of NaHCO3 increased the long-term survival of homozygous DeltaF508 mice and induced the functional expression of cystic fibrosis transmembrane conductance regulator in the luminal membrane of intestinal epithelium. CONCLUSIONS We found that base treatments correct misfolded cystic fibrosis transmembrane conductance regulator-induced defects in vitro and in vivo. These results imply that the alkalization of intracellular compartments, in particular, Golgi or pre-Golgi intermediate compartments, can be a potential therapeutic target for the loss-of-function type of conformational diseases.
Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.

BACKGROUND A region associated with sensitivity to interferon has been identified in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. The region spans amino acid residues 2209 to 2248 (NS5A2209-2248) of HCV-J, a strain of HCV-1b whose complete genomic sequence has been identified. We examined whether the NS5A2209-2248 sequence present before therapy could be used as a predictor of the response to interferon therapy in patients with chronic HCV-1b infection. METHODS We retrospectively analyzed 84 patients with chronic HCV-1b infection who had received interferon alfa (total dose, 516 million to 880 million units) for six months. Pretreatment serum samples were analyzed. The amino acid sequence of NS5A2209-2248 was determined by direct sequencing of the HCV genome amplified by the polymerase chain reaction (PCR) and was compared with the established sequence for HCV-J. RESULTS A complete response, as evidenced by the absence of HCV RNA in serum on nested reverse-transcription PCR for six months after therapy, did not occur in any of the 30 patients whose NS5A2209-2248 sequences were identical to that of HCV-J (wild type). Five of 38 patients (13 percent) with 1 to 3 changes in NS5A2209-2248 (intermediate type) had complete responses, as did all 16 patients with 4 to 11 amino acid substitutions (mutant type), indicating that the mutant type was significantly associated with a complete response (P < 0.001). Although baseline serum HCV RNA levels, as measured by a branched-chain DNA assay, were lower in patients with the mutant type of NS5A2209-2248 than in those with the other types (P < 0.001), multivariate analyses revealed that the number of amino acid substitutions in NS5A2209-2248 was the only variable associated with an independent effect on the outcome of interferon therapy (odds ratio, 5.3; 95 percent confidence interval, 1.6 to 18; P = 0.007). CONCLUSIONS In patients with chronic HCV-1b infection, there is a substantial correlation between responses to interferon and mutations in the NS5A gene.
Residential aged care nurses: portraits of resilience

Aim: To explore residential aged care nurses working in interim, rehabilitation and residential aged care perceptions of resilience. Design: Qualitative Portraiture methodology. Inclusion criteria were that all participants were English speaking, registered with the Australian Health Practitioners Registration Authority and had more than five years’ experience working in an aged care environment. Three participants were interviewed and employed within a metropolitan interim, rehabilitation and aged care setting. Results: Eight themes were identified: valuing social support; leadership, managing ‘self’; ‘paying it forward’; passion for the profession; focusing on the positive and the taking on of challenge. Conclusions: This paper focuses on the impact of aged care nursing work on nurses and in particular how the nurses remain resilient in their work environment. Resilience can be developed through education and can sustain professional longevity. Workload stress can be alleviated through the provision of resilience training.
Topical lidocaine patch relieves a variety of neuropathic pain conditions: an open-label study.

OBJECTIVE Our goal was to perform a pilot study to assess the effectiveness and tolerability of a topical lidocaine patch (Lidoderm) for the treatment of peripheral neuropathic pain conditions other than postherpetic neuralgia. DESIGN This was an open-label prospective study. PATIENTS Sixteen patients with refractory peripheral neuropathic pain conditions who had reported intolerable side effects or inadequate pain relief with antidepressant, anticonvulsant, antiarrhythmic, and opioid medications participated in this study. Diagnoses included postthoracotomy pain, stump neuroma pain, intercostal neuralgia, diabetic polyneuropathy, meralgia paresthetica, complex regional pain syndrome, radiculopathy, and postmastectomy pain. OUTCOME MEASURES A six-item Pain Relief Scale was used (0 = worse pain, 1 = no change, 2 = slight relief, 3 = moderate relief, 4 = a lot of relief, 5 = complete relief). RESULTS Moderate or better pain relief was reported by 13 of the 16 participants (81%). One patient stopped treatment after 4 days due to lack of relief. The remaining 15 patients had a mean duration of patch use of 6.2 weeks with continued relief. Only 1 patient reported a side effect, a mild skin irritation. CONCLUSIONS The Lidoderm patch provided clinically meaningful pain relief in most of these refractory neuropathic pain patients without side effects. Controlled trials need to be performed to confirm these preliminary findings.
Effect of Aerobic Exercise on Intraocular Pressure in Relation to Body Mass Index

Physiological and biochemical changes that normally occur during physical exercise are profound. This study was conducted with the aim of understanding the possible effect of physical exercise on intraocular pressure (IOP). As a part of this study, IOP was measured before and after exercise on 100 subjects (50M, 50F) with no ocular abnormality who are in the range of 18-21 years of age by using Schiotz Tonometer. Weight, height and body mass index (BMI) were recorded. The subjects were divided into two groups according to BMI. The first group consists of subjects with BMI >22 and the second with <22 BMI. Materials used in the study were Schiotz Tonometer, Measuring tape, Weighing Scale and Paracaine eye drops. The results obtained before and after exercise were compared. The data is presented as the mean ± SD. Student’s t-test is used to calculate significance between means. The IOP showed a statistically significant fall following moderate exercise. Significantly higher base line IOP is observed in subjects with >22 BMI. The present study indicates the association of BMI with intraocular pressure. Gender wise comparison of intraocular pressure did not reveal much significance.
T cell autoimmunity to histones and nucleosomes is a latent property of the normal immune system.

OBJECTIVE Investigators in this study undertook to determine whether in vitro antigen-responsive immune (polyomavirus T antigen [T-ag]- specific) and autoimmune (histone-specific) T cells from normal individuals share structural and genetic characteristics with those from patients with systemic lupus erythematosus (SLE). METHODS Histone-specific T cells were generated by stimulation of peripheral blood mononuclear cells (PBMCs) with nucleosome-T-ag complexes and were subsequently maintained by pure histones. T-ag-specific T cell clones were initiated and maintained by T-ag. The frequencies of circulating histone- and T-ag-specific T cells were determined in healthy individuals and in SLE patients by limiting dilution of PBMCs. T cell receptor (TCR) gene usage and variable-region structures were determined by complementary DNA sequencing. These sequences were compared between T-ag- and histone-specific T cells and between normal individuals and SLE patients for each specificity. RESULTS Individual in vitro-expanded histone- and T-ag-specific T cells from normal individuals displayed identical TCR V(alpha) and/or V(beta) chain third complementarity-determining region (CDR3) sequences, indicating that they were clonally expanded in vivo. The frequencies of in vitro antigen-responsive T-ag- or histone-specific T cells from normal individuals were similar to those from SLE patients. Although heterogeneous for variable-region structure and gene usage, histone-specific T cells from healthy individuals and SLE patients selected aspartic and/or glutamic acids at positions 99 and/or 100 of the V(beta) CDR3 sequence. CONCLUSION Autoimmune T cells from healthy individuals can be activated by nucleosome- T-ag complexes and maintained by histones in vitro. Such T cells possessed TCR structures similar to those from SLE patients, demonstrating that T cell autoimmunity to nucleosomes may be a latent property of the normal immune system.
The effect of an iron chelating agent on protoporphyrin IX levels and phototoxicity in topical 5‐aminolaevulinic acid photodynamic therapy

Summary Background In 5‐aminolaevulinic acid (ALA)‐photodynamic therapy (PDT), the prodrug ALA is endogenously converted to the active sensitizer protoporphyrin IX (PpIX), while further conversion of PpIX to haem requires iron.
A Single-Layered Spoof-Plasmon-Mode Leaky Wave Antenna With Consistent Gain

A single-layered leaky wave antenna (SL-LWA) exploiting the groundless spoof plasmons (SPs) structure is presented and validated to achieve consistent scanning beam and broadside gain across a wide bandwidth. The antenna is composed of single-layered meander SP cells and coplanar waveguide to SP structure converters. The periodically arranged SP cells of the SL-LWA generate a radiating space harmonic with forward, backward, and broadside radiation against frequency change. The study and experimental validation show that the proposed SL-LWA provides the consistent gain variation less than 2.5 dB of scanning beams within the 10-dB reflection bandwidth of 10.4–24.5 GHz (or 80%). In addition, the proposed antenna offers the wideband broadside radiation with 1-dB gain variation within the frequency range of 16.5–17.2 GHz (or 4.2%). The method to design the antenna operating at desired frequencies is provided. Benefiting from the low-profile compactness and unprecedented performance, the proposed SL-LWA has promising potentials for applications in wireless systems.
Detecting and Surviving Large-Scale Network Infrastructure Attacks

Abstract : This report summarizes our work on detecting and surviving large-scale network infrastructure attacks. This work investigated several different areas of infrastructure attacks including routing protocol analysis and denial of service attacks. This work produced many significant results including several patent applications as well as the commercialization of the denial of service survival tool by Arbor Networks in 2001. In addition, we have published a number of technical research reports and presented our results in public research community venues as well as in private briefings to several government organizations. This report presents the results of our analysis in the following areas: "The development and use of an innovative protocol monitoring tool," The development and demonstration of an in-line protocol scrubber designed to remove attacks from malicious network streams," The design, development, and commercialization of a tool designed to detect and mitigate denial of service attacks," Analysis of routing protocol stability and reliability including real-world analysis of both BGP and OSPF running on production networks, " Design and testing of an overlay network system designed to minimize network unavailability.
Antiprogesterone therapy uncouples axonal loss from demyelination in a transgenic rat model of CMT1A neuropathy

Charcot–Marie–Tooth disease (CMT) is the most common inherited neuropathy, and a duplication of the Pmp22 gene causes the most frequent subform CMT1A. Using a transgenic rat model of CMT1A, we tested the hypothesis that long‐term treatment with anti‐progesterone (Onapristone) reduces Pmp22 overexpression and improves CMT disease phenotype of older animals, thereby extending a previous proof‐of‐concept observation in a more clinically relevant setting.
Statistical parametric mapping of (99m)Tc-ECD SPECT in idiopathic Parkinson's disease and multiple system atrophy with predominant parkinsonian features: correlation with clinical parameters.

UNLABELLED Statistical parametric mapping was performed to investigate differences in regional cerebral blood flow (rCBF) between patients with idiopathic Parkinson's disease (IPD), patients with multiple system atrophy (MSA), and healthy volunteers. In addition, a voxel-based covariance analysis was performed with disease-specific parameters and clinical patient data such as disease duration, medication, and clinical subscores. METHODS For this purpose, (99m)Tc-ethylcysteine dimer (ECD) SPECT was performed on 81 IPD patients (50 men, 31 women; age, 62.6 +/- 10.2 y), 15 MSA patients (9 men, 6 women; age, 61.5 +/- 9.2 y), and 44 age- and sex-matched healthy volunteers (27 men, 17 women; age, 59.2 +/- 11.9 y). RESULTS Significant hypoperfusion was observed in IPD compared with healthy subjects in a symmetric subcortical-cortical network including the basal ganglia, thalami, prefrontal and lateral frontal cortex, and parietooccipital cortex (voxel P value P(height) < 0.001, corrected for multiple comparisons). For MSA, only symmetric hypoperfusion was seen in the putamen and thalamus with respect to healthy subjects and to IPD (P(height) < 0.01, corrected). Prolonged disease duration or higher Hoehn and Yahr stage results in hypoperfusion of the posterior associative cortex. There is a negative correlation between perfusion of the caudate heads and limbic system and the standardized dosage of dopamine agonists in the patients with PD, whereas for MSA a bilateral decrease in putamen activity was noted (P(height) < 0.001, uncorrected). Cognitive performance was positively correlated with limbic perfusion and inversely correlated with posterior associative cortical areas, but not with prefrontal regions. CONCLUSION Voxel-based analysis of (99m)Tc-ECD perfusion SPECT shows detailed differences between IPD and MSA, which may be of use in the differentiation of both disease entities, and is able to elucidate cerebral perfusion correlates of disease severity, dopamine agonist medication, and cognitive performance.
The fate of diethylstilbestrol in the pregnant mouse.

There is much current interest in the effect of diethylstilbestrol (DES) on the mammalian fetus; however, little is known concerning the physiologic disposition of DES during pregnancy. Radiolabeled (14C or 3H) DES (30 mug/kg) was given to 16-day pregnant mice and its metabolism, distribution and excretion were studied. After i.v. administration, DES was rapidly cleared from the plasma. The plasma decay rates could be described by the sum of four exponentials having T 1/2 values of 4 seconds, 1.1 minutes, 14 minutes and 13 hours. Moreover, conjugated products of DES accounted for more than one-half of the plasma radioactivity by 5 minutes after dosing. The parent compound was rapidly distributed to blood cells, but the liver was the major site of accumulation of DES and its metabolites. In fact, the total radioactivity in this organ accounted for 50% of the injected dose within 2.5 minutes after treatment. Significant concentrations of radioactivity persisted in liver throughout the 16-hour experiment, with DES conjugates accounting for 80% of the hepatic 14C activity at all time points examined. Approximately 56% of the dose was excreted in the feces within 24 hours, primarily as the parent compound. With DES as substrate, significant levels of UDP-glucuronyltransferase were determined in maternal and fetal liver but not in maternal uterus, placenta of fetal gut. Although the mouse placenta appeared to retard the passage of DES into the fetal compartment, a 3-fold accumulation (relative to fetal plasma) of the compound was found in the fetal reproductive tract.