Miracle-dz/UniFAR-FTUs huggingface dataset:
The changing profile of esophageal cancer presentation and its implication for diagnosis.

CONTEXT The incidence of esophageal adenocarcinoma is rising and has surpassed squamous cell carcinoma. OBJECTIVE To determine how the increasing incidence of esophageal adenocarcinoma alters the classic clinical presentation and the implications of these changes for diagnosis. DESIGN AND SETTING A five-year retrospective review (1991-1996) was made. PARTICIPANTS All patients were identified by a computerized registry search with a diagnosis of esophageal carcinoma. MAIN OUTCOME MEASURES Clinical presentation; duration of symptoms; and correlation with diagnosis, pathology, treatment and outcome. RESULTS One-hundred-eight (35%) patients had squamous cell carcinoma and 199 (65%) had adenocarcinoma. Dysphagia and weight loss were more common among patients with squamous cell carcinoma (93% and 68%), when compared to adenocarcinoma (79% and 53%). Twenty-one percent of adenocarcinoma patients had other symptoms presentation, including gastroesophageal reflux disease. Once dysphagia was present, there was no correlation between the duration.of symptoms and survival. However, cancers detected in patients who presented with reflux symptoms without dysphagia showed an improved prognosis over patients who presented with both. CONCLUSIONS Esophageal adenocarcinoma has surpassed squamous cell carcinoma. Gastroesophageal reflux was associated with an earlier stage of presentation compared to the "classic" presentation of esophageal cancer.
Spatial Dynamics of the Invasive Defoliator Amber-Marked Birch Leafminer Across the Anchorage Landscape

ABSTRACT The amber-marked birch leafminer (Profenusa thomsoni [Konow]) (Hymenoptera: Tenthredinidae) has caused severe infestations of birch species in Anchorage, AK, since 2002. Its spatial distribution has been monitored since 2006 and summarized using interpolated surfaces based on simple kriging. Results indicate that this insect pest is unevenly distributed, occurring in multineighborhood sized patches that migrate from year to year. Patches showing heavy infestation one year are followed by light infestations the following year. In this study, we developed methods of assessing and describing spatial distributions of P. thomsoni as they vary from year to year, and speculate on potential causes of these trends in landscape patterns.
TolC-Dependent Secretion of an Ankyrin Repeat-Containing Protein of Rickettsia typhi

ABSTRACT Rickettsia typhi, the causative agent of murine (endemic) typhus, is an obligate intracellular pathogen with a life cycle involving both vertebrate and invertebrate hosts. In this study, we characterized a gene (RT0218) encoding a C-terminal ankyrin repeat domain-containing protein, named Rickettsia ankyrin repeat protein 1 (RARP-1), and identified it as a secreted effector protein of R. typhi. RT0218 showed differential transcript abundance at various phases of R. typhi intracellular growth. RARP-1 was secreted by R. typhi into the host cytoplasm during in vitro infection of mammalian cells. Transcriptional analysis revealed that RT0218 was cotranscribed with adjacent genes RT0217 (hypothetical protein) and RT0216 (TolC) as a single polycistronic mRNA. Given one of its functions as a facilitator of extracellular protein secretion in some Gram-negative bacterial pathogens, we tested the possible role of TolC in the secretion of RARP-1. Using Escherichia coli C600 and an isogenic tolC insertion mutant as surrogate hosts, our data demonstrate that RARP-1 is secreted in a TolC-dependent manner. Deletion of either the N-terminal signal peptide or the C-terminal ankyrin repeats abolished RARP-1 secretion by wild-type E. coli. Importantly, expression of R. typhi tolC in the E. coli tolC mutant restored the secretion of RARP-1, suggesting that TolC has a role in RARP-1 translocation across the outer membrane. This work implies that the TolC component of the putative type 1 secretion system of R. typhi is involved in the secretion process of RARP-1.
Urinary tract infections in children: knowledge updates and a salute to the future.

UNLABELLED 1. Evaluating and treating bladder and bowel dysfunction are critical in reducing the risk of urinary tract infections (UTIs). 2. The pathogenesis of Escherichia coli infections reveals that quiescent intracellular reservoirs may be antibiotic-protected sources of recurrent infections. OBJECTIVES 1. Review the documentation of UTI and the importance of the urine culture. 2. Understand the controversy over imaging and management of febrile UTIs in children. 3. Recognize the risk factors for recurrent UTIs and strategies for intervention. 4. Update information on the pathogenesis of E coli UTIs.
FIRM-SPECIFIC CHARACTERISTICS AND TECHNICAL EFFICIENCY OF ELECTRONICS MANUFACTURING FIRMS IN CHINA

This paper analyses the technical efficiency and total factor productivity (TFP) growth of China’s electronics industries from 2006 to 2010 using stochastic production frontier model. The estimates show that the mean technical efficiency scores of electronics firms in Hong Kong and Mainland China are 63% and 90%, respectively. The estimation using the technical inefficiency effects model further reveals that firm specific characteristics, namely the capital structure, profitability, firm size and regional location, are crucial determinants of firms’ efficiency. Since firm size has a positive effect on inefficiency, small and medium-sized electronic firms appear to demonstrate a higher level of efficiency than their larger counterparts. In the TFP analysis, Hong Kong firms recorded both higher TFP growth and technological progress compared to their Chinese counterparts. In contrast, Mainland Chinese firms performed better in the context of managerial and scale efficiency.
Beijing family Mycobacterium tuberculosis strains differ in their intracellular growth in THP-1 macrophages.

SETTING Previous studies have shown that isolates from cases in IS6110 restriction fragment length polymorphism (RFLP) clusters that have persisted over several years and are widely distributed grow significantly faster in macrophages than isolates from cases with unique RFLP patterns. As members of the Beijing family of Mycobacterium tuberculosis are widely distributed and have been responsible for several large outbreaks, it has been suggested that this genotype may have a selective advantage over other strains. OBJECTIVE To determine whether rapid growth in macrophages is a common characteristic of Beijing family strains. DESIGN T-helper precursor-1 human macrophages were infected with various Beijing family strains, and intracellular growth and tumor necrosis factor alpha (TNF-alpha) secretion were assessed. Strains differed in their genotype, with IS6110 copy number ranging from 9 to 22. RESULTS Strains demonstrated a range of growth phenotypes over the 7-day infection period. Three grew significantly more slowly than the other strains, whereas the fastest growth was observed consistently with isolates of strain 210. CONCLUSION Rapid growth in macrophages is not a common characteristic of all Beijing strains. Few Beijing strains are as virulent as strain 210. The growth advantage is consistent with strain 210 having persisted many years in different locations and having caused many outbreaks.
Effectiveness of Rapid Initial Dose Escalation of up to Forty Milligrams per Day of Oral Olanzapine in Acute Agitation

Background Patients experiencing an acute decompensation of schizophrenia or bipolar disorder often present in an agitated state. Agitation presents a barrier to therapy, interrupting the typical physician-patient alliance and creating a disruptive, even hazardous, environment. Rapid assessment and effective treatment are necessary to manage agitation and, potentially, to shorten the time to recovery. Methods One hundred forty-eight acutely agitated patients received either: rapid initial dose escalation (RIDE) in which up to 40 mg of oral olanzapine was allowed on days 1 and 2, up to 30 mg on days 3 and 4, and 5 to 20 mg thereafter; or usual clinical practice (UCP) in which patients received 10 mg/d olanzapine plus up to 4 mg lorazepam on days 1 and 2, up to 2 mg on days 3 and 4, and olanzapine 5 to 20 mg/d thereafter. The Positive and Negative Syndrome Scale-Excited Component (PANSS-EC: poor impulse control, tension, hostility, uncooperativeness, and excitement) measured at 24 hours was the primary measure. Secondary assessments of agitation and safety were also performed. Results Agitation improved significantly from baseline for both treatment groups; however, improvement with the RIDE strategy was superior to UCP. The RIDE group improvement was superior on the primary efficacy measure (PANSS-Excited) at 24 hours; it was superior on all agitation measures at the end of double-blind treatment. Both treatments were well tolerated, with no clinically significant differences in safety measures. Treatment was not limited by oversedation and attention improved from baseline in both groups. Conclusions This study demonstrates the value of olanzapine in the treatment of acutely agitated patients. A new approach to olanzapine dosing that expands the initial dose range up to 40 mg/d may offer superior efficacy in rapidly and effectively controlling the symptoms of agitation.
Haloperidol-induced potentiation of latent inhibition: interaction with parameters of conditioning.

If a stimulus (e.g. tone or light) is repeatedly pre-exposed without consequences, it subsequently shows retarded conditioning when paired with a reinforcer (e.g. footshock) compared with a non-pre-exposed stimulus. This is latent inhibition (LI). Haloperidol-treated animals show potentiated LI, and it has been suggested that this is due to retarded switching to respond according to the stimulus-reinforcer contingency. Recently, it has been argued that the slowed control of behaviour by the stimulus-reinforcement contingency is due to a haloperidol-induced decrease in the impact, or salience, of the reinforcer, and thus should be antagonized by increasing the impact of reinforcement. Two experiments tested this prediction. In both, LI was assessed using an off-baseline conditioned emotional response procedure in rats licking for water. In Experiment 1, rats were given 10 light pre-exposures and conditioned with two footshocks of either a low (0.5 mA) or a high (1 mA) intensity. In Experiment 2, rats were given 30 pre-exposures and conditioned with either two or five footshocks of 1 mA. In Experiment 1, no-drug controls did not show LI at both shock intensities. Haloperidol (0.1 mg/kg) was ineffective in potentiating LI at low-intensity shock, but produced LI when shock level was increased. In Experiment 2, no-drug controls showed LI with two but not five conditioning trials. Haloperidol was ineffective in potentiating LI with two conditioning trials, but produced LI with five conditioning trials. Although the effect of haloperidol on LI could thus be modified by manipulating shock intensity or the number of conditioning trials, the direction of such modification indicates that the potentiating effect of haloperidol on LI is not in general antagonized by increasing the impact of reinforcement.
Cine‐ASL: A steady‐pulsed arterial spin labeling method for myocardial perfusion mapping in mice. Part II. Theoretical model and sensitivity optimization

In small rodent myocardial perfusion studies, the most widely used method is based on Look‐Locker measurements of the magnetization recovery after FAIR preparation, which bears limitations regarding acquisition efficiency due to the pulsed arterial spin labeling nature of the sequence. To improve efficiency, this two‐article set proposes a new steady‐pulsed arterial spin labeling scheme using a cine readout incorporating one tagging pulse per heart cycle. In this part, we derive a theoretical description of the magnetization time evolution in such a scheme. The combination of steady‐pulsed labeling and cine readout drives tissue magnetization into a stationary regime that explicitly depends on perfusion. In comparison with dedicated experiments on the mouse heart, the model is discussed and validated for perfusion quantification. The model predicts that in this regime, signal is independent of irregular dynamics occurring during acquisition, such as heart rate variations or arterial input function. Optimization of the sequence offers the possibility to increase the signal to noise ratio by efficient signal averaging. The sensitivity of this new method is shown to be more than three times larger than previously used techniques. Magn Reson Med 70:1399–1408, 2013. © 2012 Wiley Periodicals, Inc.
Teachers’ perception on the relationships between transformational leadership and school culture in primary cluster schools

Education is a key factor contributing to the success of a nation’s human development to support the national vision and mission. The nation depends on schools to ensure the efficient and successful education process for human development. In fact, studies on educational progress have proven that leadership is important for school success and high performance. The vast literature has supported that transformational leadership of school principals is the proven leadership attribute in school success and achievement. Thus, this study aims at examining the relationships between principals’ transformational leadership practices and school culture in primary cluster schools in the state of Selangor, Malaysia. A quantitative approach was used to achieve the aim. The study included 331 teachers in primary cluster schools in Selangor and data were analysed using SPSS v.22. The findings indicated that teachers in primary cluster schools in Selangor perceived their principals as having a high level of transformational leadership characteristics. Furthermore, a significantly positive and a strong correlation was found between principal transformational leadership practices and school culture. Multiple regression analysis showed that only four out of the eight dimensions of transformational leadership are statistically significant predictors of school culture. It is recommended that the education authorities and principals take note of the importance of transformational leadership in ensuring school success.
An invariant relation between changing over and reinforcement.

Although concurrent schedules may arrange reinforcers irregularly, relatively large numbers of reinforcers are obtained when an animal changes from one schedule to the other. This paper proposes a quantitative relation that predicts the proportion of reinforcers obtained when an animal is working on a schedule and the proportion when the animal changes over to a schedule. Basically the relation states that the number of reinforcers obtained while an animal works on a schedule varies directly with the relative amount of time spent working on that schedule; and the number of reinforcers obtained when an animal changes to a schedule varies directly with the relative amount of time spent on the alternate schedule. An important aspect of this relation is that when relative reinforcement rates are less than . 50, more reinforcers are obtained just after an animal changes to a schedule than at all other times when this schedule is engaged. Data obtained both from a stat-bird and a live pigeon were in close agreement with the quantitative predictions. The relation between changing over and reinforcement held across several procedural changes that included changes in relative reinforcement rate, changes from independent to interdependent scheduling procedures, and changes in the variable-interval reinforcement distributions. The results are discussed in terms of the effects of the local distribution of reinforcement on responding. The local reinforcement distribution can affect local response rates and affects the resulting matching relation. This arrangement has implications for explanations of choice.
Economic and environmental impacts of raising revenues for climate finance from public sources

ABSTRACT In response to anthropogenic climate change, developed countries have committed themselves to raising 100 billion USD a year from 2020 onwards to address the needs of developing countries. In this paper, we investigate the economic consequences and CO2 emission impacts of three options for raising climate funds from public sources in developed countries: (i) CO2 emissions pricing, (ii) an electricity consumption tax, and (iii) the removal of fossil fuel subsidies. Using computable general equilibrium analysis, we find that these three options not only induce very different global costs to raise given amounts of climate funds, but also have quite diverging implications for the cost incidence between developed and developing countries. Likewise, the global CO2 emission impacts of alternative fund-raising policies differ significantly. Key policy insights CO2 emission pricing and a tax on electricity consumption in developed countries shift substantial shares of the cost burden for raising climate finance to developing countries, while the removal of fossil fuel subsidies in developed countries leads to welfare gains for developing countries. While CO2 pricing and a tax on electricity consumption lead to positive carbon leakage, i.e. increased emissions in developing countries, the removal of fossil fuel subsidies incentivizes decarbonization of developing economies through higher prices for fossil fuels. From a global cost-effectiveness perspective the removal of subsidies is the least attractive option, but it gains in attractiveness for a policy portfolio when taking into account the cost incidence between developed and developing countries, and also the impact on CO2 emissions in developing countries.
The Relationships Between the Unified Parkinson’s Disease Rating Scale and Lower Extremity Functional Performance in Persons With Early-Stage Parkinson’s Disease

Background. The Unified Parkinson’s Disease Rating Scale (UPDRS) is the “gold standard” assessment tool for characterizing impairments in persons with Parkinson’s disease (PD); however, this scale’s ability to predict functional capabilities across different functional tasks has not been adequately assessed in persons with early-stage PD. Methods. Thirty persons with PD within 3 years of diagnosis and without motor fluctuation performed self-selected walking, fast walking, and sit-to-stand and stair-climbing tasks. Pearson’s correlation coefficients were used to calculate correlations with a standard UPDRS examination (P < .05). Simple linear regression models were used to fit each functional performance outcome measure with the UPDRS total predictor scores. Results. The correlations between the UPDRS motor (section III), UPDRS total scores, and all timed functional performance measures were fair to good (range, 0.45-0.57). Conversely, only greater self-selected time to walk 50 ft correlated with a higher UPDRS activities of daily living (II) score ( r = .386; P < .05). Conclusions. The UPDRS motor (III) and total scores may be good predictors of overall lower extremity function in persons with early-stage PD. Understanding the relationships between UPDRS scores and functional capabilities may allow clinicians to better quantify early physical functioning, longitudinally assess disease progression, and assess the efficacy of interventions.
Transport and arrangement of the outer-dynein-arm docking complex in the flagella of Chlamydomonas mutants that lack outer dynein arms.

The outer dynein arms of Chlamydomonas flagella are attached to a precise site on the outer doublet microtubules and repeat at a regular interval of 24 nm. This binding is mediated by the outer dynein arm docking complex (ODA-DC), which is composed of three protein subunits. In this study, antibodies against the 83- and 62-kD subunits (DC83 and DC62) of the ODA-DC were used to analyze its state of association with outer arm components within the cytoplasm, and its localization in the axonemes of oda mutants. Immunoprecipitation indicates that DC83 and DC62 are preassembled within the cytoplasm, but that they are not associated with outer arm dynein. Both proteins are lost or greatly diminished in oda1 and oda3, mutants in the structural genes of DC62 and DC83, respectively, demonstrating that their association is necessary for their stable presence in the cytoplasm. Immunoelectron microscopy indicates that DC83 repeats at 24-nm intervals along the length of the doublet microtubules of oda6, which lacks outer arms; thus, outer arm periodicity may be determined by the ODA-DC. Flagellar regeneration and temporary dikaryon experiments indicate that the ODA-DC can be rapidly transported into the flagellum and assembled on the doublet microtubules independently of the outer arms and independently of flagellar growth. Unexpectedly, the intensity of ODA-DC labeling decreased toward the distal ends of axonemes of oda6 but not wild-type cells, suggesting that the outer arms reciprocally contribute to the assembly/stability of the ODA-DC.
The contribution of personality and workplace characteristics in predicting turnover intention among sexual assault nurse examiners: A path analytic study

&NA; The purpose of this study was to determine how personality characteristics, sense of organizational empowerment, and job satisfaction combine to predict turnover intention among a population of Sexual Assault Nurse Examiners (SANEs). Data were collected from 161 SANEs from 23 SANE organizations across the central and west United States through standardized tools and a demographic questionnaire. Both personality, namely agreeableness and workplace characteristics, particularly perceived empowerment and job satisfaction, combine to predict intention to leave the job of these sampled SANEs. One particularly curious finding was the positive prediction of agreeableness on turnover intention – that is, more agreeable people would be more likely to leave their jobs as SANEs. Professionals can gain insight from the path analysis results that show the need to address both personal and organizational factors in mitigating turnover intention among SANEs. This appears to be particularly true in providing a sense of empowerment and opportunity within the organization.