Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of chlorhexidine, hydrogen peroxide and tulsi extract mouthwash in reducing halitosis using spectrophotometric analysis: A randomized controlled trial

Background To evaluate the efficacy of tulsi extract mouthrinse in reducing halitosis as compared to chlorhexidine and hydrogen peroxide mouthrinses using spectrophotometric analysis. Material and Methods It was a parallel, single center, double blinded randomized controlled trial of 15 days duration. A total of 300 participants were screened, out of which 45 subjects those fulfilled inclusion criteria of age range 17-35 years were included in the trial. The participants were randomly provided with tulsi, hydrogen peroxide or chlorhexidine mouthwashes (control group) to use 10 ml twice daily for 15 days. Clinical measurements were taken at baseline and 15 days using arbitrary 0-5 scale for organoleptic odor assessments, spectrophotometric analysis for Volatile Sulphide Compounds (VSCs) from saliva samples, Löe & Silness gingival index and Silness & Löe plaque index. Results After intervention, organoleptic, VSCs, gingival and plaque scores showed statistically significant decrease in all the three study groups. The mean percentage reduction in VSC and organoleptic scores was significantly greater in chlorhexidine and hydrogen peroxide groups than in the tulsi group and the mean percentage reduction in plaque and gingival scores was significantly greater in chlorhexidine group than in hydrogen peroxide and tulsi group. Conclusions Tulsi may not have the efficacy of chlorhexidine and hydrogen peroxide mouthrinses. But, Tulsi is effective in reducing halitosis, plaque and gingivitis and with its lack of side effects & cost effectiveness, can be an effective & economic tool to deal with halitosis. The spectrophotometric technique appears to be a promising method for evaluation of oral malodor. Key words:Halitosis, tulsi mouthwash, chlorhexidine, hydrogen peroxide, spectrophotometric analysis.
An Exploration of Merit Pay, Teacher and Student Satisfaction, and Teacher Performance Evaluation from an Instructional Perspective

In higher education, teachers’ teaching effectivene ss in the classroom is an essential to improve the quality of higher educatio n. However, teachers’ teaching effectiveness comes from the personal motivation, p erception, and satisfaction in the teachers’ jobs. The merit incentive compensation sy stem is directly linked to teachers’ motivation and perception, which also directly or i ndirectly results in satisfaction with teachers’ career and students’ learning in the clas sroom. This study investigates the factors in teachers’ performance evaluated in Chine se classrooms by students and teachers, and teachers’ demographic characteristics (DC), which impact on teachers’ merit pay, and teachers’/students’ satisfaction. St udy participants were Chinese students and teachers working in or enrolled in one of four different higher education systems from 2012 to 2013 semesters in Nanjing, China. Our sample contains 457 teachers and 9,017 students. The data was collected via online q uestionnaires. Henschke’s Modified Instructional Perspectives Inve ntory (MIPI) (Henschke, 1989) was used to evaluate teachers’ performance in the classroom from instructional perspectives. The MIPI includes seven factors: Fact or 1: Teacher Empathy with Students; Factor 2: Teacher Trust of Students; Factor 3: Plan ning and Delivery of Instruction; Factor 4: Accommodating Student Uniqueness; Factor 5: Teacher Insensitivity toward Students; Factor 6: Experience-Based Learning Techn iques (Learner-Centered Learning Process); and Factor 7: Teacher-Centered Learning P rocess. The MIPI-s, an adaptation of the MIPI, was used to evaluate student’s perception s of teacher performance in the Lu, Yunlin, 2014, UMSL III classroom from an instructional perspective. Studen ts a d teachers reported satisfaction with learning and teaching using a Likert-type scale in a demographic questionnaire. This study utilized a quantitative approach with s tandard multiple regression analysis. There were three dependent variables: tea chers’ merit pay, teachers’ satisfaction, and students’ satisfaction. The indep endent variables included DC factors related to teachers’ motivation and perception, and seven factors of MIPI and MIPI-s with 45-items respectively. The results of regressi on analyses demonstrated significant relationships as a whole between teachers’ merit pa y and teachers’/students’ satisfaction with teaching/learning, factors in teachers’ demogr aphic characteristics, and seven factors of MIPI/MIPI-S respectively. Lu, Yunlin, 2014, UMSL IV
Preferences for Policy Options for Deceased Organ Donation for Transplantation: A Discrete Choice Experiment

Background Despite broad public support for organ donation, there is a chronic shortage of deceased donor organs. We sought to identify community preferences for features of organ donation policies. Methods A discrete choice study was conducted using an online panel of Australian community respondents older than 18 years. Respondents were presented with scenarios comparing a “new” policy to the current policy. Tradeoffs between 8 policy aspects were quantified using mixed logit and latent class models: registration system, extent of donor family involvement, ease of registration, frequency of confirmation of intent, direct payment, and funeral expense reimbursement, priority for donor's family, and formal recognition of donation. Results There were 2005 respondents (mean, 44.6 years). We found a strong preference for a new policy. Overall, respondents favored a policy that included: some involvement of the donor's family in the final decision, simple registration processes, less frequent reconfirmation of donation intent, direct payment or funeral expense reimbursement, and formal recognition of donation. However, there was significant preference heterogeneity across respondents, with various respondent groups valuing policy mechanisms differently. Respondents who viewed policy change negatively were also those who would be unlikely to be organ donors anyway, because they tended to hold negative views toward organ donation. Conclusions Our results suggest that the Australian community are open to alternative organ donation policies including changes to: registration systems, family involvement, and financial and nonfinancial mechanisms. Future policy discussions should not be limited by preconceived notions of what is acceptable to the community, rather informed by actual community values and preferences.
Ketoprofen poly(lactide-co-glycolide) physical interaction

The aim of this work was to provide an understanding of the interaction occurring between ketoprofen and poly(lacticco-glycodic acid) (PLGA) that leads to polymer plasticization. Experimental glass transition temperature (Tg) values were fitted with the theoretical ones predicted by the Fox and Gordon-Taylor/Kelley-Bueche equations. PLGA films containing different amounts of ketoprofen (KET) were prepared by solvent casting and characterized by scanning electron microscopy, differential scanning calorimetry, and Fourier transform infrared spectroscopy (FTIR). Differential scanning calorimetry evidenced that KET acted as a plasticizer in a similar biphasic way in both end-capped and uncapped PLGA. At KET contents of 20% to 35%, depending on the investigated polymer, the Tg was around 23°C. Higher KET amounts did not lower further the Tg, and the excess of drug was found to crystallize into the polymeric matrix. Experimental Tg's deviated negatively from the predicted ones probably because of hydrogen bonding. The FTIR spectra of the films, loaded with different amounts of KET, showed a shift to higher wavenumbers for the peaks at 1697 and 1655 cm−1 confirming the presence of some interactions, probably hydrogen bonds between the ketoprofen carboxylic group and the PLGA carbonyl groups along the polymer backbone. The hydrogen bonding between KET and PLGA is probably responsible for KET plasticizing effect. KET behaving as a lubricant may disrupt polymer chain-chain interactions, removing additional barriers to bond rotation and chain mobility.
Depression symptoms in Canadian psychology graduate students: Do research productivity, funding, and the academic advisory relationship play a role?

Depression is one of the most common psychological disorders affecting university students (Rimmer, Halikas, & Schuckit, 1982; Vazquez & Blanco, 2008); however, undergraduate students have received the majority of the research focus. The limited research available on graduate students suggests they may also be vulnerable to developing depression (Eisenberg, Gollust, Golberstein, & Hefner, 2007). The current investigation provides initial data on depression symptoms in Canadian psychology graduate students. Participants included psychology graduate students from across Canada (N 292; 87% women) who were currently enrolled in clinical, experimental, counselling, and educational programmes. Each of the participants completed the Center for Epidemiological Studies Depression Scale (CES-D; Radloff, 1977) and measures of: funding, research productivity, hours worked, and their advisory relationship. A substantial proportion of students (33%) reported clinically significant symptoms of depression (CES-D 16), with a significant minority reporting severe symptoms of depression and impairment. There were no differences in symptom reporting across programme type; however, results of regression analyses indicated that advisory relationship satisfaction and greater current weekly hours worked were significant predictors of depressive symptoms for students enrolled in experimental programmes. In contrast, depression symptoms were unrelated to funding, research productivity, hours worked, and advisory relationship satisfaction for students in all other programmes. Implications and future directions for research are discussed.
Differential modulation of sodium channel Nav1.6 by two members of the fibroblast growth factor homologous factor 2 subfamily

FHF2A and FHF2B are two members of the fibroblast growth factor homologous factor 2 (FHF2) subfamily with distinct N termini. Using a generic antibody and electrophysiological methods, we previously showed that FHF2 is expressed in hippocampus and dorsal root ganglion (DRG) neurons and is colocalized with sodium channel Nav1.6 at sensory but not motor nodes of Ranvier, and that FHF2B associates with Nav1.6, causing an increase in current density and a small depolarizing shift in availability of channels. Using immunolabeling of adult rat tissue, we demonstrate that FHF2A is present within DRG but not in hippocampal or cerebellar neurons or at nodes of Ranvier in sciatic nerve, and that Nav1.6 and FHF2A are colocalized in nonmyelinated fibers. We also show that FHF2A binds directly to Nav1.6, and that the two proteins coimmunoprecipitate from transfected HEK293 cells. Because Nav1.6 has been associated with rapid firing rates, we examined the possible effects of FHF2B and the sister isoform, FHF2A, on electrophysiological properties of this channel in the DRG‐derived ND7/23 cell line. We show that FHF2B inhibits accumulation of inactivation in response to trains of stimulation at high frequencies. In marked contrast, FHF2A causes an accumulation of inactivated channels at all frequencies tested due to a slowing of recovery from inactivation. Thus different FHF2 subfamily members have different functional effects on Nav1.6 and are differentially distributed in DRG neurons and their axons. This suggests that FHF2A and FHF2B may selectively alter firing behaviour of specific neuronal compartments via differential modulation of Nav1.6.
Living in wealthy neighborhoods increases material desires and maladaptive consumption

Despite the presumed national economic benefits that result from high levels of discretionary spending, past studies suggest that material consumption decreases individual economic and subjective well-being. However, most research on the development of materialistic values has examined how persuasive materialistic messages cause materialism. We recruited 2702 participants to test our prediction that living in wealthy neighborhoods should increase material desires and maladaptive consumption in much the same way it decreases happiness. Interestingly, our regression models revealed that individual socioeconomic status (SES) and neighborhood SES have unique, and opposite, predictive patterns of material consumption. Specifically, after controlling for age, gender, and population size, greater neighborhood SES predicted greater desires for material consumption, more impulsive buying, and fewer savings behaviors while individual SES showed the reverse pattern. Our path model suggests that greater neighborhood SES leads to increased material desires, which then predicts more frequent impulsive buying, and fewer savings behaviors. We discuss why neighborhood SES might change values and consumer behaviors.
Efficient molecular subtype classification of high‐grade serous ovarian cancer

High‐grade serous carcinomas (HGSCs) account for approximately 70% of all epithelial ovarian cancers diagnosed. Using microarray gene expression profiling, we previously identified four molecular subtypes of HGSC: C1 (mesenchymal), C2 (immunoreactive), C4 (differentiated), and C5 (proliferative), which correlate with patient survival and have distinct biological features. Here, we describe molecular classification of HGSC based on a limited number of genes to allow cost‐effective and high‐throughput subtype analysis. We determined a minimal signature for accurate classification, including 39 differentially expressed and nine control genes from microarray experiments. Taqman‐based (low‐density arrays and Fluidigm), fluorescent oligonucleotides (Nanostring), and targeted RNA sequencing (Illumina) assays were then compared for their ability to correctly classify fresh and formalin‐fixed, paraffin‐embedded samples. All platforms achieved > 90% classification accuracy with RNA from fresh frozen samples. The Illumina and Nanostring assays were superior with fixed material. We found that the C1, C2, and C4 molecular subtypes were largely consistent across multiple surgical deposits from individual chemo‐naive patients. In contrast, we observed substantial subtype heterogeneity in patients whose primary ovarian sample was classified as C5. The development of an efficient molecular classifier of HGSC should enable further biological characterization of molecular subtypes and the development of targeted clinical trials. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The Effect of Fluoride on the Stability of Oral Bacterial Communities in vitro

An in vitro model system has been used to study the combined influences of fermentable carbohydrate, pH, and fluoride on the stability of complex oral microbial communities. The pH generated from carbohydrate pulses rather than the availability of substrate per se was responsible for the enrichment of the cariogenic species S. mutans and L. casei. The addition of sub-MIC levels of sodium fluoride (1 mmol/L; 19 ppm) reduced both the rate of acid production and the fall in terminal pH from glucose pulses, thereby enabling pH-sensitive bacteria, including many Gram-negative species, to persist. Furthermore, the combination of even a moderately-low environmental pH (ca. pH 5.0) with a low level (1 mmol/L) of fluoride was able to prevent S. mutans from out-competing other species and resulted in its proportions within the bacterial community remaining low. By this mechanism, fluoride could make a significant contribution to preventing dental caries.
A Contextual Comparison of Risk Behaviors among Older Adult Drug Users and Harm Reduction in Suburban Versus Inner-city Social Environments

Recent epidemiological data show that older adults comprise a growing age group of drug users and new AIDS cases in the United States. Prevention and intervention studies show that risk behaviors leading to HIV infection are increasing among older users, particularly among the socially vulnerable. Yet older adults remain an underresearched population of drug users and little is known about their risk behaviors. Our aim is to address this gap in knowledge on older users by comparing contextual factors that influence risk behaviors and harm reduction strategies practiced by older drug users living in different communities. This study is based on ethnographic fieldwork in suburban and inner-city neighborhoods in a large metropolitan area in the southeastern United States. Interviewers conducted face-to-face, in-depth, life history interviews with 69 older adults (ages 45 and older) who used heroin, cocaine, and/or methamphetamine. Findings show that while risk behaviors were similar among older adult drug users living in suburban and inner-city environments, the provision of harm reduction education and paraphernalia varied widely. The results show the need for the expansion of harm reduction services focused on older adult drug users who are homeless, uninsured, or socially isolated. This application-oriented research will inform health care and treatment providers and generate new directions for future collaborative harm reduction services aimed to decrease the spread of HIV and other infectious diseases associated with drug use.
Molecular Serotyping of Escherichia coli O26:H11

ABSTRACT Serotyping is the foundation of pathogenic Escherichia coli diagnostics; however, few laboratories have this capacity. We developed a molecular serotyping protocol that targets, genetically, the same somatic and flagellar antigens of E. coli O26:H11 used in traditional serotyping. It correctly serotypes strains untypeable by traditional methods, affording primary laboratories serotyping capabilities.
Postprandial hormone and metabolic responses in simulated shift work.

This study was designed to investigate postprandial responses to a mixed meal in simulated shift work conditions. Nine normal healthy subjects (six males and three females) were studied on two occasions at the same clock time (1330 h) after consuming test meals, first in their normal environment and secondly after a 9 h phase advance (body clock time 2230 h). Plasma glucose, insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), triacylglycerol (TAG) and non-esterified fatty acids (NEFAs) were determined at intervals for 6 h after each test meal. Postprandial plasma glucose, insulin, GIP and GLP-1 profiles were evaluated by calculating areas under the curve (AUC) for the first 2 h and the last 4 h of the sampling together with total AUC. Significantly higher postprandial glucose responses (total AUC) were observed after the phase shift than before (AUC 0-360 min, 2.01 (1.51-2.19) vs 1.79 (1.56-2.04) mmol/l.min; P < 0.02; mean (range)). No significant difference was observed when the first 2 h of each response was compared, but significantly higher glucose levels were observed in the last 4 h of the study after the phase shift than before (AUC 120-360 min, 1.32 (1.08-1.42) vs 1.16 (1.00-1.28) mmol/l.min; P < 0.05). Similar results were obtained for insulin (AUC 0-360 min, 81.72 (30.75-124.97) vs 58.98 (28.03-92.57) pmol/l.min; P < 0.01; AUC 120-360 min, 40.73 (16.20-65.25) vs 25.71 (14.25-37.33) pmol/l.min; P < 0.02). No differences were observed in postprandial plasma GIP and GLP-1 responses before and after the phase shift. Postprandial circulating lipid levels were affected by phase shifting. Peak plasma TAG levels occurred 5 h postprandially before the phase shift. Postprandial rises in plasma TAG were significantly delayed after the phase shift and TAG levels continued to rise throughout the study. Plasma postprandial NEFA levels fell during the first 3 h both before and after the phase shift. Their rate of return to basal levels was significantly delayed after the phase shift compared with before. This study demonstrates that a simulated phase shift can significantly alter pancreatic B-cell responses and postprandial glucose and lipid metabolism.
Can hand dexterity predict the disability status of patients with multiple sclerosis?

Background: Multiple Sclerosis (MS) is the most common disabling neurological disease. Hand dysfunction is one of the main complaints of patients with MS. The present study aimed to compare hand dexterity of MS patients with low Expanded Disability Status Scale (EDSS) scores and healthy adults. It also sought to identify the predictors of disability status of patients with MS based on their manual dexterity and demographic characteristics. Methods: In this cross-sectional study, 60 (16 male/44 female) patients with MS and 60 (19 male/41 female) healthy people, who matched in terms of age and sex, were recruited. Their hand dexterity was evaluated by the Purdue Pegboard Test. The disability status of the MS group was determined by the Expanded Disability Status Scale. The data were analyzed using SPSS15. Results: The hand dexterity in MS group even with low EDSS score (1.5 ± 1.07) was weaker than control group. Moreover, the dexterity of dominant hand and alternating two hands coordination subtests of the PPT was a good discriminator between two groups (p<0.001). The results of linear regression analysis suggested dominant hand dexterity and disease duration as predictors of disability status that predict 60.5 per cent of the variation in EDSS scores in patients with MS (p<0.001). Conclusion: Reduced dominant hand dexterity in patients with MS is a disabling factor. Further research is recommended to determine if early hand rehabilitation can reduce the severity of disability in Patients with MS.
Interaction between nutrition and Eimeria acervulina infection in broiler chickens: diet compositions that improve fat digestion during Eimeria acervulina infection

Previously an experimental infection model was developed in which broiler chickens were inoculated with sporulated Eimeria acervufina oocysts at an age of 18 d. The infection resulted in adverse performance results and reduced nutrient digestion. In two new experiments with the infection model effects of diet adjustments on fat digestion were investigated. In the first experiment addition of 0·4 g cholic acid/kg to a diet rich in animal fat resulted in increased fat digestion during the infection. In the second experiment replacing animal fat by coconut oil resulted in improved fat digestion during the coccidiosis infection. However, replacement of animal fat by soyabean oil did not improve fat digestion.
Does the Short Form of the Alcohol Use Disorders Identification Test (AUDIT-C) Work at a Trauma Emergency Department?

The accuracy of the consumption items of AUDIT (AUDIT-C) was analyzed, using the full AUDIT score as gold standard, in 120 traffic casualties (78% men and 22% women), median age 27 years (IQR = [22–34]), entering an urban emergency room between 2001 and 2003, with (67%) and without (33%) a positive blood alcohol level (≥0.2 g/L). Sensitivity, specificity, predictive value, overall accuracy, and receiver operating characteristics of AUDIT-C were measured. Diagnostic accuracy was 0.79, using cutoff indices of ≥5 for males and ≥4 for females. AUDIT-C may be useful in emergency departments for a stepwise screening. Further validation of this test with larger samples and different settings is warranted.