Miracle-dz/UniFAR-FTUs huggingface dataset:
Simulation analysis of transient piezoelectric properties of PvDF structure for energy conversion applications

Rapid development of wireless sensor networks and portable electronic devices calls for solutions to self-powered micro-systems. In this work, two models based on polyvinylidene fluoride (PvDF) structure which convert mechanical energy into electric energy is studied via COMSOL Multi-physics simulation. A series of time-dependent transient analyses are conducted and it is observed that strains and output voltages generally follow the changes of applied stresses when the frequency of the applied stress is at 1 Hz. With a fixed frequency, output voltage and short circuit current increase with applied strain and with a fixed strain, the current increase with the frequency while the output voltage remains relatively stable. The theoretical energy conversion coefficient is 14.39% for the cantilever model and 13.23% for the membrane model, which is higher than results of practical experiments.
Extensive neurological recovery from a complete spinal cord injury: a case report and hypothesis on the role of cortical plasticity

Neurological recovery in patients with severe spinal cord injury (SCI) is extremely rare. We have identified a patient with chronic cervical traumatic SCI, who suffered a complete loss of motor and sensory function below the injury for 6 weeks after the injury, but experienced a progressive neurological recovery that continued for 17 years. The extent of the patient's recovery from the severe trauma-induced paralysis is rare and remarkable. A detailed study of this patient using diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), and resting state fMRI (rs-fMRI) revealed structural and functional changes in the central nervous system that may be associated with the neurological recovery. Sixty-two percent cervical cord white matter atrophy was observed. DTI-derived quantities, more sensitive to axons, demonstrated focal changes, while MTI-derived quantity, more sensitive to myelin, showed a diffuse change. No significant cortical structural changes were observed, while rs-fMRI revealed increased brain functional connectivity between sensorimotor and visual networks. The study provides comprehensive description of the structural and functional changes in the patient using advanced MR imaging technique. This multimodal MR imaging study also shows the potential of rs-fMRI to measure the extent of cortical plasticity.
Actigraph measures discriminate pediatric bipolar disorder from attention-deficit/hyperactivity disorder and typically developing controls.

BACKGROUND Distinguishing pediatric bipolar disorder (BD) from attention-deficit hyperactivity disorder (ADHD) can be challenging. Hyperactivity is a core feature of both disorders, but severely disturbed sleep and circadian dysregulation are more characteristic of BD, at least in adults. We tested the hypothesis that objective measures of activity, sleep, and circadian rhythms would help differentiate pediatric subjects with BD from ADHD and typically developing controls. METHODS Unmedicated youths (N = 155, 97 males, age 5-18) were diagnosed using DSM-IV criteria with Kiddie-SADS PL/E. BD youths (n = 48) were compared to typically developing controls (n = 42) and children with ADHD (n = 44) or ADHD plus comorbid depressive disorders (n = 21). Three-to-five days of minute-to-minute belt-worn actigraph data (Ambulatory Monitoring Inc.), collected during the school week, were processed to yield 28 metrics per subject, and assessed for group differences with analysis of covariance. Cross-validated machine learning algorithms were used to determine the predictive accuracy of a four-parameter model, with measures reflecting sleep, hyperactivity, and circadian dysregulation, plus Indic's bipolar vulnerability index (VI). RESULTS There were prominent group differences in several activity measures, notably mean 5 lowest hours of activity, skewness of diurnal activity, relative circadian amplitude, and VI. A predictive support vector machine model discriminated bipolar from non-bipolar with mean accuracy of 83.1 ± 5.4%, ROC area of 0.781 ± 0.071, kappa of 0.587 ± 0.136, specificity of 91.7 ± 5.3%, and sensitivity of 64.4 ± 13.6%. CONCLUSIONS Objective measures of sleep, circadian rhythmicity, and hyperactivity were abnormal in BD. Wearable sensor technology may provide bio-behavioral markers that can help differentiate children with BD from ADHD and healthy controls.
Political reputations and campaign promises

We analyze conditions under which candidates' reputations may affect voters' beliefs over what policy will be implemented by the winning candidate of an election. We develop a model of repeated elections with complete information in which candidates are purely ideological. We analyze an equilibrium in which voters' strategies involve a credible threat to punish candidates who renege on their campaign promises and in which all campaign promises are believed by voters and honored by candidates. We characterize the maximal credible campaign promises and find that the degree to which promises are credible in equilibrium is an increasing function of the value of a candidate's reputation. (JEL: D8) (c) 2007 by the European Economic Association.
Protein Factor Requirements of the Apaf-1 Internal Ribosome Entry Segment: Roles of Polypyrimidine Tract Binding Protein and upstream of N-ras

ABSTRACT It has been reported previously that the 5′ untranslated region of the mRNA encoding Apaf-1 (apoptotic protease-activating factor 1) has an internal ribosome entry site (IRES), whose activity varies widely among different cell types. Here it is shown that the Apaf-1 IRES is active in rabbit reticulocyte lysates, provided that the system is supplemented with polypyrimidine tract binding protein (PTB) and upstream of N-ras (unr), two cellular RNA binding proteins previously identified to be required for rhinovirus IRES activity. In UV cross-linking assays and electrophoretic mobility shift assays with individual recombinant proteins, the Apaf-1 IRES binds unr but not PTB; however, PTB binding occurs if unr is present. Over a range of different cell types there is a broad correlation between the activity of the Apaf-1 IRES and their content of PTB and unr. In cell lines deficient in these proteins, overexpression of PTB and unr stimulated Apaf-1 IRES function. This is the first example where an IRES in a cellular mRNA has been shown to be functionally dependent, both in vitro and in vivo, on specific cellular RNA binding proteins. Given the critical role of Apaf-1 in apoptosis, these results have important implications for the control of the apoptotic cascade.
Overview of Romania 802.11 wireless networks security

This paper presents a study of wireless network security and statistics in Romania aimed at raising public awareness on known issues and highlighting the prevalence of known vulnerabilities in commercial equipment. The data used for the study consist of wireless network broadcast data acquisitioned by the technique of war-driving. In order to ensure a thorough overview, the data collected includes more than 100000 unique wireless networks gathered in Bucharest, major urban areas and the surrounding countryside. The results of the study cover security protocol usage, the percentage in which known vulnerabilities are still deployed in wireless networks and statistics regarding common SSIDs in Romania.
Angiosperm leaf vein patterns are linked to leaf functions in a global-scale data set.

PREMISE OF THE STUDY Leaves are plants' primary interface with the atmosphere and affect a range of ecological processes. Vein patterns are one of the most prominent aspects of leaf form, and the functional significance of different vein patterns is gaining increasing attention. METHODS Phylogenetic and standard ANOVA and regression were used to provide the first global-scale, phylogenetically based test of relations between angiosperm vein patterns and leaf functional traits. Pagel's λ was used to test for phylogenetic signal in all traits. KEY RESULTS All leaf traits had significant phylogenetic signal. Significant phylogenetically based relations were found between secondary vein pattern and leaf functions, linking leaf form to the well-known trade-off between physiological activity and leaf life span. The relations between primary vein pattern and leaf functions were not found to be significant with phylogenetic tests, suggesting these relations may be the result of changes within a few lineages, followed by phylogenetic conservatism, rather than multiple instances of correlated trait evolution. The relation between minor vein density and maximum photosynthetic rate was found to be marginally nonsignificant with phylogenetic regression, which does not rule out coordinated evolution of hydraulic supply and demand. CONCLUSIONS Although phylogenetic conservatism may weaken statistical relations between vein patterns and leaf functions, phylogenetic relations can provide a complementary source of information for inferring unmeasured values of leaf traits. Relations among vein patterns, leaf functions, and phylogeny will be valuable for estimating functional attributes of living and fossil plant species and communities.
Mean platelet volume and arterial stiffness in patients with acromegaly.

OBJECTIVE There are still contradictory data in the literature whether patients with acromegaly are under risk in terms of atherosclerotic heart disease. Increased arterial stiffness develops before atherosclerosis and is evaluated to be a risk factor for atherosclerosis. Mean platelet volume (MPV) is currently gaining interest as a new independent cardiovascular risk factor. There are contrasting views about arterial stiffness in patients with acromegaly. There is no report in literature studying MPV in acromegaly patients. The aim of this study was to evaluate MPV and arterial stiffness in patients with acromegaly. METHODS This study was designed as an observational cross-sectional, case-controlled study. Twenty-eight patients with acromegaly and 22 healthy volunteers were recruited for the study. The arteriography device Mobil-O-Graph® (IEM GmbH. Stolberg, Germany) which can perform oscillometric measurements was used to measure arterial stiffness. The Mann-Whitney U test, Student's t-test, Spearman's nonparametric correlation analysis and the chi-square test were used to statistical analyze. RESULTS Aortic pulse wave velocity (PWV) value was found to be 6.41 ± 2.12 m/s in the patient group with active acromegaly and 5.24 ± 1.04 m/s in the healthy control group. The difference was statistically significant (p=0.03). The mean MPV value was found to be 9.68 ± 1.11 in the patient group with active acromegaly and 8.53 ± 1.18 in the healthy control group. There was a statistically significant difference between the two groups (p=0.004). In patients with acromegaly, a positive correlation was found between MPV and insulin-like growth hormone-I (IGF-1) level (p=0.021, r=0.434). CONCLUSION We determined an increase in aortic PWV and MPV in patients with acromegaly. In conclusion, evaluation of MPV and arterial stiffness in future studies could be beneficial in determining the risks for cardiovascular disease in patients with acromegaly.
Shared and divergent expression domains on mimetic Heliconius wings

SUMMARY Heliconius butterfly wing patterns show repeated convergence between species and have adaptive value in mimicry and mate choice, offering an opportunity to connect adaptive changes in phenotype with their underlying genotypes. Here we study forewing ommochrome pigmentation in Heliconius melpomene. We clone two new ommochrome pathway genes for the Lepidoptera, karmoisin and kynurenine formamidase (kf ), and analyze the expression patterns of all known ommochrome genes across pupal wing development. In combination with published work, this generates the first comparative gene expression data for the co‐mimics Heliconius erato and H. melpomene. In both species cinnabar expression correlates with the forewing band, but the expression pattern of vermillion differs significantly between the mimics. This demonstrates that both shared and divergent expression patterns are associated with mimetic phenotypes between Heliconius species. Two genes not studied in H. erato, scarlet and possibly kf, also show enhanced expression in the forewing band of H. melpomene, implying co‐ordinated upregulation of several members of this biosynthetic pathway during pattern formation.
Endotoxin tolerance does not limit mild ischemia-reperfusion injury in humans in vivo

Animal studies have shown that previous exposure to lipopolysaccharide (LPS) can limit ischemia-reperfusion injury. We tested whether pretreatment with LPS also protects against ischemia-reperfusion injury in humans in vivo. Fourteen volunteers received bolus injections of incremental dosages of LPS on 5 consecutive days (LPS group). Before the first and 1 day after the last LPS administration, the forearm circulation of the non-dominant arm was occluded for 10 min, with concomitant intermittent handgripping to induce transient ischemia. After reperfusion, 0.1 mg of 99mTc-labeled annexin A5 (400 MBq) was injected intravenously to detect phosphatidylserine expression as an early marker of ischemia-reperfusion injury. Similarly, the control group (n = 10) underwent the ischemic exercise twice, but without pretreatment with LPS. Annexin A5 targeting was expressed as the percentage difference in radioactivity in the thenar muscle between both hands. Endotoxin tolerance developed during 5 consecutive days of LPS administration. Annexin A5 targeting was 12.1 ± 2.2% and 10.4 ± 2.1% before LPS treatment at 1 h and 4 h after reperfusion, compared to 12.2 ± 2.4% and 8.9 ± 2.1% at 1 h and 4 h after reperfusion on day 5 (P = 1.0 and 0.6, respectively). Also, no significant changes in annexin A5 targeting were found in the control group. So, in this model, LPS-tolerance does not protect against ischemia-reperfusion injury in humans in vivo.
Preliminary Evaluation of Prostate Cancer Metastatic Risk Biomarkers

Prostate cancer patients at high risk of metastasis need to be identified as early as possible since metastasis is invariably fatal. Treatment could be tailored to risk. Recent array comparative genomic hybridization (aCGH) studies of primary and metastatic prostate tumors identified 39 BAC clones capable of detecting genomic signatures of metastasis. We termed these loci the genomic evaluators of metastatic CaP (GEMCaP). Risk assessments were made on a set of men who were managed with radical prostatectomy. We compared the utility of GEMCaP loci and the Kattan nomogram, a common risk assessment tool, in relation to biochemical outcome. This preliminary evaluation experiment suggests we can use aCGH to detect genomic signatures of metastasis in primary tumors with an accuracy of 78%. The classification accuracy for the Kattan nomogram was 75%. Therefore, validation of GEMCaP is warranted in a larger, appropriately designed cohort.
The actions of barium and strontium on exocytosis and endocytosis in the synaptic terminal of goldfish bipolar cells

1 We investigated the properties of Ca2+‐sensitive steps in the cycling of synaptic vesicles by comparing the actions of Ca2+, Ba2+ and Sr2+ in the synaptic terminal of depolarizing bipolar cells isolated from the retina of goldfish. FM1‐43 fluorescence and capacitance measurements demonstrated that exocytosis, endocytosis and vesicle mobilization were maintained when external Ca2+ was replaced by either Ba2+ or Sr2+. 2 The rapidly releasable pool of vesicles (RRP) was equivalent to 1.5 % of the membrane surface area when measured in the presence of 2.5 mm Ca2+, but only 0.4 % in 2.5 mm Sr2+. The relative sizes of the RRP in Ca2+, Sr2+ and Ba2+ were 1.0, 0.28 and 0.1, respectively. We conclude that a smaller proportion of docked vesicles are available for fast exocytosis triggered by the influx of Sr2+ or Ba2+ compared to Ca2+. 3 The slow phase of exocytosis was not altered when Ca2+ was replaced by Ba2+, but it was accelerated 1.6‐fold in Sr2+. The peak concentrations of Ca2+, Sr2+ and Ba2+ (measured using Mag‐fura‐5) were ≈4, ≈14 and ≈60 μm, respectively. The order of efficiency for the stimulation of slow exocytosis was Ca2+≈ Sr2+ > Ba2+. 4 Exocytosis was prolonged after the influx of Sr2+ and Ba2+. Sr2+ was cleared from the synaptic terminal with the same time constant as Ca2+ (1.3 s), but Ba2+ was cleared 10‐100 times more slowly. Although Ba2+ stimulates the slow release of a large number of vesicles, it did so less efficiently than Ca2+ or Sr2+. 5 The recovery of the membrane capacitance was equally rapid in Sr2+ and Ca2+, demonstrating that the fast mode of endocytosis could be triggered by either cation.
Family Mealtime While Growing Up: Associations With Symptoms of Bulimia Nervosa

The purpose of this study was to examine associations between bulimia nervosa and family meals. Female college students ( N = 560) completed surveys assessing eating disorder pathology, family meal frequency, and family environment. Results indicate that dinner was the meal most frequently shared with family members. The frequency of eating dinner together as a family was inversely associated with scores on two measures of bulimia, and these associations remained statistically significant after controlling for other familial factors. Familial variables associated with bulimic symptoms included low cohesion and independence, and high achievement orientation. While results indicate that bulimic behaviors are inversely associated with the frequency of a family dinner, these relationships need to be explored within the context of broader family dynamics. Individuals working in primary and secondary prevention settings should evaluate family meal patterns and dynamics in families with a member with an eating disorder.
Apparent molecular weights of a heat-modifiable protein from the outer membrane of Escherichia coli in gels with different acrylamide concentrations

The apparent molecular weights of the two forms of a heat-modifiable protein from the outer membrane of Escherichia coli K-12, estimated in gels with different concentrations of acrylamide, indicate that the protein binds excess amounts of sodium dodecyl sulfate, possibly due to large beta structures before boiling.
Clinical Significance of EEG Abnormalities During Photic Stimulation in Patients with Photosensitive Epilepsy

Summary: Purpose: The continued presence of EEG abnormalities in patients with a history of photosensitive seizures is used to signify the persistence of photosensitive epilepsy. The extent to which this approach places patients at risk of seizures is unclear, however. We describe those EEG abnormalities that may be tolerated with low risk of further seizures, and those that are indicative of poor seizure control.
The human heart proteome: Two‐dimensional maps using narrow‐range immobilised pH gradients

The analysis of complex proteomes is undertaken using a variety of techniques and technologies such as 2‐DE, surface‐enhanced laser desorption ionisation, and various types of MS. In order to overcome the complexities of protein expression in discrete proteomes, sample fractionation has become an important aspect of proteomic experiments. The use of narrow‐range IPGs (nrIPGs) is of special importance using the 2‐DE proteomics workflow, since an enhanced visualisation of a given proteome is achieved through an improved physical separation and resolution of proteins. The work described in this paper presents a series of protein maps of the human heart left ventricle proteome that have been generated using nrIPGs for the first, IEF, dimension of 2‐DE. A total of 374 gel spots were excised from seven different pH gradients, covering the range pH 3–10, giving rise to a total of 388 identifications from 110 unique proteins. Using Gene Ontologies (GOs), the identified proteins were found to be associated with 97 types of GO Process, 144 types of GO Function, and 54 types of GO Component. It is hoped that the maps presented in this paper will be of use to other researchers for reference purposes.
Disparities by ethnicity, language, and immigrant status in occupational health experiences among Las Vegas hotel room cleaners.

OBJECTIVE We examined disparities in workers' occupational health experiences. METHODS We surveyed 941 unionized Las Vegas hotel room cleaners about their experiences with work-related pain and with employers, physicians, and workers' compensation. Data were analyzed for all workers and by ethnicity, language, and immigrant status. RESULTS Hispanic and English as second language (ESL) workers were more likely than their counterparts to report work-related pain and, along with immigrant workers, to miss work because of this pain. Hispanic, ESL, and immigrant workers were not consistently at a disadvantage with regard to their own responses to work-related pain but were so with respect to reported responses by workers' compensation, physicians, and employers. CONCLUSIONS There are indications of disparities in occupational health experiences within this job title. The use of different group classifications, while implying different mechanisms, produced similar results.
Possible health effects of high manganese concentration in drinking water.

Three areas in the same region of northwest Peloponnesos, Greece, that had varying concentrations of manganese (Mn) in drinking water were selected for study. The Mn concentrations in areas A, B, and C were 3.6-14.6 micrograms/l, 81.6-252.6 micrograms/l, and 1 800-2 300 micrograms/l, respectively. A random sample (62 in area A, 49 in area B, and 77 in area C) of males and females who were at least 50 y of age were submitted to a thorough neurological examination and their whole-blood Mn and hair Mn concentrations were determined. Although all areas were similar with respect to social and dietary characteristics, significant differences were observed for prevalence of chronic manganese poisoning (CMnP) symptoms and hair Mn concentration. The means (both sexes) of neurological scores were 2.7, 3.9, and 5.2, respectively, for areas A, B, and C (Kruskal-Wallis, chi 2 = 6.44, 2 df, p less than .05 for males; chi 2 = 7.8, 2 df, p less than .05 for females). Hair Mn concentrations were also significantly different, the means for which were 3.51, 4.49, and 10.99 micrograms/g dry weight, respectively (both sexes [p less than .001 for each sex separately]). These results indicate that progressive increases of Mn concentration in drinking water are associated with progressively higher prevalences of neurological signs of CMnP and Mn concentration in hair of older persons.