Miracle-dz/UniFAR-FTUs huggingface dataset:
Total wrist arthroplasty: a systematic review of the evidence from the last 5 years

We reviewed evidence on total wrist replacement from the last 5 years. Eight articles met a minimum set standard. The results of 405 prostheses were available, including seven different manufacturers. The mean follow up was 2.3–7.3 years with an average age of 52–63. Rheumatoid arthritis was the indication in 42% of patients. Motec demonstrated the best post-operative DASH scores. Only Maestro achieved a defined functional range of motion post-operatively. Universal 2 displayed the highest survival rates (100% at 3–5 years), while Elos had the lowest (57% at 5 years). Biaxial had the highest complication rates (68.7%), while Remotion had the lowest (11%). Wrist arthroplasty preserves some range of motion. Functional scores improved and were maintained over the mid- to long-term. Complication rates were higher than wrist fusion, with reports of radiological loosening and osteolysis. The evidence does not support the widespread use of arthroplasty over arthrodesis, and careful patient selection is essential. Level of Evidence: III
COMPARATIVE PHOTO ACTIVITY OF TIN and ZINC PORPHYRIN INHIBITORS OF HEME OXYGENASE: PRONOUNCED PHOTOLABILITY OF THE ZINC COMPOUNDS

Metalloporphyrin inhibitors of heme oxygenase may also have photosensitizing properties in vivo. To assess photoactivity in serum, the relative ability to mediate photooxidation of tryptophan or other oxidizable targets, presumably by singlet oxygen production, was measured for tin mesopor‐phyrin, zinc mesoporphyrin, and zinc deuteroporphyrin bisglycol in aqueous solution and when bound to human serum albumin. While tin mesoporphyrin sensitized at the greatest initial rate in aqueous solution, the zinc compounds sensitized at a greater initial rate in detergent micelles or when bound to albumin. There was minimal alteration of the tin mesoporphyrin during the time course of illumination in the Soret or visible absorption regions. The zinc compounds, however, proved to be extremely photolabile and were extensively destroyed by light; the photooxidized forms were found to be ineffective as inhibitors of heme oxygenase.
Evaluation of rice (Oryza sativa)-based cropping systems for increasing productivity, resource-use efficiency and energy productivity in coastal West Bengal

A field experiment was conducted during 201113 at farmers field of Kakdwip in the district South 24 Parganas of West Bengal to assess productivity, profitability, resource-use efficiency including energy value under coastal saline zone with 6 different rice (Oryza sativa L.)based cropping systems, viz. ricegreengram [Vigna radiata (L.) Wilczek], ricesunflower (Helianthus annuus L.), ricesunflower + greengram, riceokra [Abelmoschus esculentus (L.) Moench], ricerice and ricekhasari (Lathyrus sativus L.) (as utera). The highest rice-equivalent yield was re- corded in riceokra (33.6 t/ha) cropping system. Higher productivity, net returns and profitability also recorded in riceokra system followed by ricesunflower. However, higher benefit: cost ratio was obtained from riceokra sys- tem (2.03) followed by ricekhasari (1.85) and the lowest from ricegreengram (1.52) system. Riceokra system showed better land-utilization efficiency (69.1%) followed by ricesunflower than the other systems. Riceokra system also showed higher irrigation water-use efficiency (1,416.3 kg/ha-cm) and employment generation (475 man-days) than the other systems. Total input, output and net energy produced in the systems were in order of riceokra > ricerice > ricesunflower > ricesunflower+greengram > ricegreengram > ricekhasari. Riceokra system was the most efficient in term of energy productivity (0.45 kg/MJ). Energy-use efficiency was the highest in ricekhasari followed by ricesunflower + greengram and ricegreengram. The riceokra cropping system proved the most remunerative cropping system in the coastal saline zone of West Bengal.
White Teachers' Experiences of Working with Black Students within a Response to Intervention Framework: The Role of Racialized Deficit Thinking

Response to Intervention (RTI) is a data-based decision-making framework of service delivery that has the potential to improve educational outcomes for all students. Preliminary data appear to bolster this claim. However, it is as yet unclear whether RTI will be able to close the gap in educational outcomes that exists between students of different racial groups. Drawing on theories such as culture of policy (Stein, 2004) and deficit thinking (Valencia, 2010), this study explored the experiences of six White elementary teachers using RTI while working with Black students receiving Tier 2 or Tier 3 instructional supports. Using theoretically driven constantcomparative analysis, I illustrated how teachers’ personal worldviews as well as local contexts informed their different interpretations of RTI as well as their similar interpretive lens: racialized deficit-based thinking while talking about the causes of the racial gap in schooling outcomes as well as while talking about specific Black students in their classrooms. While speaking about specific students, teachers drew on deficit thinking to explain the roots of problems (e.g., low motivation, lack of parental involvement), and paid comparatively little attention to problems in instruction, curriculum, or other contextual factors. Findings are discussed in light of Stein’s (2004) work showing how the culture of policy operates at the school level, and how even equity-oriented policies can be negated by deficit-oriented perspectives and practices.
Processive proofreading and the spatial relationship between polymerase and exonuclease active sites of bacteriophage phi29 DNA polymerase.

phi29 DNA polymerase is a multifunctional enzyme, able to incorporate and to proofread misinserted nucleotides, maintaining a very high replication fidelity. Since both activities are functionally separated, a mechanism is needed to guarantee proper coordination between synthesis and degradation, implying movement of the DNA primer terminus between polymerization and 3'-5' exonuclease active sites. Using single-turnover conditions, we have demonstrated that phi29 DNA polymerase edits the polymerization errors using an intramolecular pathway; that is, the primer terminus travels from one active site to the other without dissociation from the DNA. On the other hand, by using chemical tags, we could infer a difference in length of only one nucleotide to contact the primer strand when it is in the polymerization mode versus the editing mode. Using the same approach, it was estimated that phi29 DNA polymerase covers a DNA region of ten nucleotides, as has been measured in other polymerases using different techniques.
Instrumental client relationship development among top-ranking service professionals

ABSTRACT Informal client contact forms a crucial part of the daily routine of service professionals, in particular among top-ranking professionals working for consultancy and accountancy firms. In this paper, we investigate how 34 service professionals develop informal client contact, by studying their networking styles. Our study shows many similarities in informal client contact between two groups of service professionals grouped by gender, but we also found subtle differences in what we coin instrumental and expressive relations. Contrary to gender stereotypes, we found that female service professionals tended toward instrumental networking styles, using professionalism and distance and allowing the high quality of their work compensate for network deficits, contingent upon their clients’ gender. Male service professionals drew on expressive relations to develop emotional bonding with their male clients in particular, but nonetheless toward instrumental purposes. Our study contributes to service industries literature by theoretically and empirically establishing the different informal networking styles between top-ranking service professionals, and the role of emotional bonding in particular. In doing so, the paper helps to better understand the intricacies of informal client contact as a critical dimension of the professional services industry.
Rethinking small political parties: from micro to peripheral

ABSTRACT It is frequently suggested that ‘micro parties’ are opportunist organisations out to ‘game the system’. These parties are regularly compared with supposed minor parties. There are two problems with this approach. First, attempts to operationalise ‘micro party’ have been ad hoc. Second, comparisons between ‘micro’ and minor parties are erroneous as a party type is being compared with a classification based on the relevance of parties in the party system. In rethinking small parties, the term ‘micro party’ should be discarded as it lacks utility. Parties referred to as ‘micro parties’ should be re-classified, and the classification of parties in the party system needs refinement. In particular, we should include an additional class of party in these classifications, peripheral parties.
Sweating is greater in NCAA football linemen independently of heat production.

PURPOSE The study's purpose was to investigate whether differences in local sweat rates on the upper body between American football linemen (L) and backs (B) exist independently of differences in metabolic heat production. METHODS Twelve NCAA Division I American football players (6 linemen (mass = 141.6 ± 6.5 kg, body surface area (BSA) = 2.67 ± 0.08 m2) and 6 backs (mass = 88.1 ± 13.4 kg, BSA = 2.11 ± 0.19 m2)) cycled at a fixed metabolic heat production per unit BSA of 350 W·m(-2) for 60 min in a climatic chamber (t(db) [dry bulb temperature] = 32.4°C ± 1.0°C, t(wb) [wet bulb temperature] = 26.3°C ± 0.6°C, v [air velocity] = 0.9 ± 0.1 m·s(-1)). Local sweat rates on the head, arm, shoulder, lower back, and chest were measured after 10, 30, and 50 min of exercise. Core temperature, mean skin temperature, and HR were measured throughout exercise. RESULTS Because metabolic heat production per unit surface area was fixed between participants, the rate of evaporation required for heat balance was similar (L = 261 ± 35 W·m(-2), B = 294 ± 30 W·m(-2), P = 0.11). However, local sweat rates on the head, arm, shoulder, and chest were all significantly greater (P < 0.05) in linemen at all time points, and end-exercise core temperature was significantly greater (P = 0.033) in linemen (38.5°C ± 0.4°C) relative to backs (38.0°C ± 0.2°C) despite a ∼25% lower heat production per unit mass. The change in mean skin temperature from rest was greater in linemen (P < 0.001) after 15, 30, 45, and 60 min, and HR was greater in linemen for the last 30 min of exercise. CONCLUSIONS Football linemen sweat significantly more on the torso and head than football backs independently of any differences in metabolic heat production per unit BSA and therefore the evaporative requirements for heat balance. Despite greater sweating, linemen demonstrated significantly greater elevations in core temperature suggesting that sweating efficiency (i.e., the proportion of sweat that evaporates) was much lower in linemen.
Exposure to air pollution and crime in the neighbourhood: Evidence from life satisfaction data in Turkey

Purpose The purpose of this paper is to explore the determinants of life satisfaction in Turkey. Moreover, this study explores the effects of air pollution and crime problems on well-being. Design/methodology/approach The estimates are based on cross-sectional data from the health survey in Turkey during the years 2010 and 2012. Various econometric models are applied such as the ordered logit and the random-effects generalized latent class ordered logit. Moreover, using pseudo panel data created based on age and region cohorts adapted probit fixed effects and the “blow-up and cluster” estimators are applied. In addition, various estimates by sex, age group, urban and rural areas as well as between individuals with good and poor health status are followed. Findings The results show that the individuals who self-reported who are exposed to air pollution and crimes present on average 0.2-0.5 less satisfaction scores than those who are not exposed to air pollution and crimes. In terms of monetary values, they are willing to pay more than those who are not exposed to air pollution and crimes by 13-19 Turkish Liras per month. Moreover, the generalized latent class ordered logit shows that there is considerable heterogeneity among the most satisfied and least satisfied individuals. Originality/value The originality of the paper lies in the fact that this is the first study to provide an analysis of life satisfaction using micro-level data from Turkey. Moreover, various econometric approaches are applied to compare the results. In addition, examining the heterogeneous effects among individuals with different life satisfaction rankings, it is possible to examine the effects of various factors on well-being and how they differ among individuals. Finally, by examining exposure to air pollution and crimes in the neighbourhood and their effects on well-being, it is possible to control for characteristics of the deprived areas.
The Quantified Self: Fundamental Disruption in Big Data Science and Biological Discovery

A key contemporary trend emerging in big data science is the quantified self (QS)-individuals engaged in the self-tracking of any kind of biological, physical, behavioral, or environmental information as n=1 individuals or in groups. There are opportunities for big data scientists to develop new models to support QS data collection, integration, and analysis, and also to lead in defining open-access database resources and privacy standards for how personal data is used. Next-generation QS applications could include tools for rendering QS data meaningful in behavior change, establishing baselines and variability in objective metrics, applying new kinds of pattern recognition techniques, and aggregating multiple self-tracking data streams from wearable electronics, biosensors, mobile phones, genomic data, and cloud-based services. The long-term vision of QS activity is that of a systemic monitoring approach where an individual's continuous personal information climate provides real-time performance optimization suggestions. There are some potential limitations related to QS activity-barriers to widespread adoption and a critique regarding scientific soundness-but these may be overcome. One interesting aspect of QS activity is that it is fundamentally a quantitative and qualitative phenomenon since it includes both the collection of objective metrics data and the subjective experience of the impact of these data. Some of this dynamic is being explored as the quantified self is becoming the qualified self in two new ways: by applying QS methods to the tracking of qualitative phenomena such as mood, and by understanding that QS data collection is just the first step in creating qualitative feedback loops for behavior change. In the long-term future, the quantified self may become additionally transformed into the extended exoself as data quantification and self-tracking enable the development of new sense capabilities that are not possible with ordinary senses. The individual body becomes a more knowable, calculable, and administrable object through QS activity, and individuals have an increasingly intimate relationship with data as it mediates the experience of reality.
A 36–80 GHz High Gain Millimeter-Wave Double-Balanced Active Frequency Doubler in SiGe BiCMOS

This letter presents a high conversion gain double-balanced active frequency doubler operating from 36 to 80 GHz. The circuit was fabricated in a 200 GHz fT and fmax 0.18 ¿m SiGe BiCMOS process. The frequency doubler achieves a peak conversion gain of 10.2 dB at 66 GHz. The maximum output power is 1.7 dBm at 66 GHz and -3.9 dBm at 80 GHz. The maximum fundamental suppression of 36 dB is observed at 60 GHz and is better than 20 dB from 36 to 80 GHz. The frequency doubler draws 41.6 mA from a nominal 3.3 V supply. The chip area of the active frequency doubler is 640 ¿m × 424 ¿m (0.272 mm 2) including the pads. To the best of authors' knowledge, this active frequency doubler has demonstrated the highest operating frequency with highest conversion gain and output power among all other silicon-based active frequency doublers reported to date.
ISCHAEMIC PENUMBRA: HIGHLIGHTS

The ischaemic penumbra was described for the first time in the late 1970s as a ring of hypoperfused zone surrounding the region of complete infarction. The penumbral zone is a functionally silent tissue which is able to regain its function if promptly reperfused. This implies that the ischaemic penumbra is not a static but a “dynamic” and “time-dependent” concept. In this paper we describe the role of neuroimmaging tecniques such as single photon emission tomography (SPET), positron emission tomography (PET), and diffusion-weighted and perfusion-weighted magnetic resonance imaging (DWI and PWI) in the study of ischaemic penumbra. These functional imaging techniques have the advantage of giving “in vivo” quantitative estimate of cerebral blood flow (CBF) as well as information on how the ischaemic tissue metabolic changes develop. It follows that, as therapeutic options for treating acute stroke evolve, neuroimaging strategies are assuming an increasingly important role in the initial evaluation and management of the acute ischaemic patient. In this regard, a wide range of therapeutic approaches have been investigated for either ameliorating the perfusion, or interfering with the pathobiochemical cascade leading to ischaemic neuronal damage, or improving endogenous neuroprotection pathways The “time windows” required for these treatments to be effective varies being rather short for reperfusion and longer for neuroprotection. Salvaging more penumbra would enhance recovery and thereby allow the most appropriate candidate for therapeutic trials to be selected.
Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease

We explored the neural substrate of anosognosia for cognitive impairment in Alzheimer's disease (AD). Two hundred nine patients with mild to moderate dementia and their caregivers assessed patients' cognitive impairment by answering a structured questionnaire. Subjects rated 13 cognitive domains as not impaired or associated with mild, moderate, severe, or very severe difficulties, and a sum score was calculated. Two measures of anosognosia were derived. A patient's self assessment, unconfounded by objective measurements of cognitive deficits such as dementia severity and episodic memory impairment, provided an estimate of impaired self‐evaluative judgment about cognition in AD. Impaired self‐evaluation was related to a decrease in brain metabolism measured with 18F‐2‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography (FDG‐PET) in orbital prefrontal cortex and in medial temporal structures. In a cognitive model of anosognosia, medial temporal dysfunction might impair a comparison mechanism between current information on cognition and personal knowledge. Hypoactivity in orbitofrontal cortex may not allow AD patients to update the qualitative judgment associated with their impaired cognitive abilities. Caregivers perceived greater cognitive impairments than patients did. The discrepancy score between caregiver's and patient's evaluations, an other measure of anosognosia, was negatively related to metabolic activity located in the temporoparietal junction, consistent with an impairment of self‐referential processes and perspective taking in AD. Hum Brain Mapp, 2005. © 2005 Wiley‐Liss, Inc.
EEG coupling features: Towards mental workload measurement based on wearables

Automated mental workload measurement is particularly important in safety-critical settings, such as in nuclear plants, aviation, air traffic control, shipping, and transportation, to name a few. As an example, recent statistics have suggested that 90% of the accidents in the transport industry are due to human factors. In this paper, we explore the potential of off-the-shelf wearable technologies in monitoring mental workload in real-time, thus potentially reducing the number of accidents due to human errors. Wearable technologies, while providing the user with ease-of-use, comfort, and portability, have several limitations, such as lower quality signal readings (e.g., due to dry electrodes) and smaller number of recording sites. Such limitations place a burden on the accuracy of existing mental workload models. To overcome this limitation, we propose the use of phase-amplitude and amplitude-amplitude coupling features computed from a portable commercial electroencephalography (EEG) device. Experiments with three different tasks, namely N-back, mental rotation and visual search, show the proposed features being significantly correlated with multiple dimensions of the widely-used NASA task load index test and providing complementary information to other conventional features.
Combination of Heel-strike like Mechanical Loading with Deproteinized Cancellous Bone Scaffold Implantation to Repair Segmental Bone Defects in Rabbits

Under physiological conditions bone defects often occur at mechanical load bearing sites and bone substitutes used for regeneration should be similarly subjected to mechanical loading stress. In this study, we investigated whether a novel heel-strike like mechanical loading method can be used as a complementary therapy to promote bone regeneration following bone substitute grafting. To test this, three groups of rabbits with segmental bone defects in the tibia were implanted with bovine deproteinized cancellous bone scaffold (DCBS), with one group also receiving heel-strike like mechanical loading generated by a rap stress stimulator. From weeks 4-12 post-operation X-ray and micro-CT scanning showed that rabbits receiving combination therapy had significantly more callus at the bone defect. Moreover, bone defects in the combination group were completely replaced with new bone at week 12, while the DCBS implantation alone group healed only partially and rabbits receiving neither DCBS nor mechanical loading developed only small calluses throughout the observation period. Analysis of micro-CT scanning results demonstrated that new bone density in the combination group was significantly higher than the DCBS only group at weeks 4 and 12 (p<0.05). H&E staining results also indicated a significantly higher percentage of new bone in the bone defect area and a lower percentage of residual scaffold in the combination group compared to the DCBS only group (p<0.05). Thus, this heel-strike like mechanical loading method appears to accelerate bone regeneration following substitute implantation by restoring a local mechanical loading environment in segmental bone defects.
European guidelines for quality assurance in colorectal cancer screening and diagnosis. – First Edition Faecal occult blood testing

Multidisciplinary, evidence-based guidelines for quality assurance in colorectal cancer screening and diagnosis have been developed by experts in a project coordinated by the International Agency for Research on Cancer. The full guideline document covers the entire process of population-based screening. It consists of 10 chapters and over 250 recommendations, graded according to the strength of the recommendation and the supporting evidence. The 450-page guidelines and the extensive evidence base have been published by the European Commission. The chapter on faecal occult blood testing includes 21 graded recommendations. The content of the chapter is presented here to promote international discussion and collaboration by making the principles and standards recommended in the new EU Guidelines known to a wider professional and scientific community. Following these recommendations has the potential to enhance the control of colorectal cancer through improvement in the quality and effectiveness of screening programmes and services.