Miracle-dz/UniFAR-FTUs huggingface dataset:
Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical response.

The aim of this study was to examine the tolerability, antitumor activity, and biological effects of a new schedule of i.v. recombinant human interleukin 12 (rhIL-12). Twenty-eight patients were enrolled in a Phase I trial in which rhIL-12 was administered twice weekly as an i.v. bolus for 6 weeks. Stable or responding patients were eligible to receive additional 6-week cycles until there was no evidence of disease or until tumor progression. Patient cohorts were treated with escalating doses of rhIL-12 (30-700 ng/kg). The maximum tolerated dose (MTD) was 500 ng/kg, with dose-limiting toxicities consisting of elevated hepatic transaminases and cytopenias. At the MTD (n = 14), there was one partial response occurring after 6 cycles of rhIL-12 in a patient with renal cell cancer. Two additional renal cell cancer patients treated at the MTD had prolonged disease stabilization, with one of these exhibiting tumor regression after 8 cycles of rhIL-12. IFN-gamma, IL-15, and IL-18 were induced in patients treated with rhIL-12. Whereas IFN-gamma and IL-15 induction were attenuated midway through the first cycle in patients with disease progression, those patients with tumor regression or prolonged disease stabilization were able to maintain IFN-gamma, IL-15, and IL-18 induction. The down-modulation of IFN-gamma induction during rhIL-12 treatment did not relate to IL-10 production or alterations in rhIL-12 bioavailability but was associated with an acquired defect in lymphocyte IFN-gamma production in response to IL-12, IL-2, or IL-15. This defect could be partially overcome in vitro through combined stimulation with IL-12 plus IL-2. These findings show that the chronic administration of twice-weekly i.v. rhIL-12 is well-tolerated, stimulates the production of IL-12 costimulatory cytokines and IFN-gamma, and can induce delayed tumor regression. Strategies aimed at maintaining IFN-gamma induction, such as the addition of IL-2, may further augment the response rate to this schedule of rhIL-12.
The accuracy of computational fluid dynamics analysis of the passive drag of a male swimmer

The aim of this study was to build an accurate computer-based model to study the water flow and drag force characteristics around and acting upon the human body while in a submerged streamlined position. Comparisons of total drag force were performed between an actual swimmer, a virtual computational fluid dynamics (CFD) model of the swimmer, and an actual mannequin based on the virtual model. Drag forces were determined for velocities between 1.5 m/s and 2.25 m/s (representative of the velocities demonstrated in elite competition). The drag forces calculated from the virtual model using CFD were found to be within 4% of the experimentally determined values for the mannequin. The mannequin drag was found to be 18% less than the drag of the swimmer at each velocity examined. This study has determined the accuracy of using CFD for the analysis of the hydrodynamics of swimming and has allowed for the improved understanding of the relative contributions of various forms of drag to the total drag force experienced by submerged swimmers.
Multiwavelength analysis for interferometric (sub-)mm observations of protoplanetary disks - Radial constraints on the dust properties and the disk structure

Context. The growth of dust grains from sub-mu m to mm and cm sizes is the first step towards the formation of planetesimals. Theoretical models of grain growth predict that dust properties change as a function of disk radius, mass, age, and other physical conditions. High angular resolution observations at several (sub-)mm wavelengths constitute the ideal tool with which to directly probe the bulk of dust grains and to investigate the radial distribution of their properties. Aims. We lay down the methodology for a multiwavelength analysis of (sub-) mm and cm continuum interferometric observations to self-consistently constrain the disk structure and the radial variation of the dust properties. The computational architecture is massively parallel and highly modular. Methods. The analysis is based on the simultaneous fit in the uv-plane of observations at several wavelengths with a model for the disk thermal emission and for the dust opacity. The observed flux density at the different wavelengths is fitted by posing constraints on the disk structure and on the radial variation of the grain size distribution. Results. We apply the analysis to observations of three protoplanetary disks (AS 209, FT Tau, DR Tau) for which a combination of spatially resolved observations in the range similar to 0.88 mm to similar to 10 mm is available from SMA, CARMA, and VLA. In these disks we find evidence of a decrease in the maximum dust grain size, a(max), with radius. We derive large a(max) values up to 1 cm in the inner disk 15 AU <= R <= 30 AU and smaller grains with a(max) similar to 1 mm in the outer disk (R greater than or similar to 80 AU). Our analysis of the AS 209 protoplanetary disk confirms previous literature results showing a(max) decreasing with radius. Conclusions. Theoretical studies of planetary formation through grain growth are plagued by the lack of direct information on the radial distribution of the dust grain size. In this paper we develop a multiwavelength analysis that will allow this missing quantity to be constrained for statistically relevant samples of disks and to investigate possible correlations with disk or stellar parameters.
Alternate Stoichiometries of α4β2 Nicotinic Acetylcholine Receptors

Two functional types of nicotinic acetylcholine receptors (nAChRs) are expressed when human embryonic kidney cells are permanently transfected with equal amounts of human alpha4 and beta2 subunit cDNAs. Most (82%) of these nAChRs exhibit an EC(50) of 74 +/- 6 microM for ACh, a much lower sensitivity than the remaining fraction (EC(50) of 0.7 +/- 0.4 microM) or than expected from expression of equal amounts of alpha4 and beta2 mRNAs in Xenopus laevis oocytes. We have found three conditions that can increase the number of nAChRs with high sensitivity to activation. These are: 1) transient transfection with additional beta2 subunits, 2) overnight incubation in nicotine, or 3) overnight culture at 29 degrees C. Using metabolic labeling with [(35)S]methionine to measure subunit stoichiometry, we found that the majority of nAChRs had a stoichiometry of (alpha4)(3)(beta2)(2). Overnight treatment with nicotine increased the number of nAChRs and increased the proportion of the (alpha4)(2)(beta2)(3) stoichiometry. Alternate alpha4beta2 nAChR stoichiometries with distinct functional properties raise the possibility for an interesting mode of synaptic regulation for nicotinic signaling in the mammalian brain.
Dualized Topic-Preserving Pseudo Relevance Feedback for Question Answering

SUMMARY This study proposes an e ﬀ ective pseudo relevance feed-back method for information retrieval in the context of question answering. The method separates two retrieval models to improve the precision of initial search and the recall of feedback search. The topic-preserving query expansion links the two models to prevent the topic shift. key words
International Market Expansion Strategies for High-Tech Firms: Partnership Selection Criteria for Forming Strategic Alliances

Newly established, technology-based firms entering international markets often have limited resources in terms of capabilities, time, and capital. As a consequence, these firms often use entry modes characterised by low resource commitment, including partnership agreements (strategic alliances). This paper, investigates which partner selection criteria that are important for this group of firms when they are selecting partners. Based on case studies of three Norwegian firms targeting the UK market, five selection criteria have been identified as important (trust, relatedness of business, access to networks, access to market knowledge, reputation), one has been identified as partly important (sharing of financial risk), and ten have been identified as having limited importance. Further, the paper discusses the implications of these results for managers of small firms entering international markets and presents recommendations for further research.
The Changing Role of the CIO in the World of Outsourcing: Lessons Learned from a CIO Roundtable

The increasing availability of readymade and supposedly ready to use IT packages is changing the way CIOs manage and the challenges they face. In this article we summarize the opinions of CIOs who attended a roundtable to discuss this issue. The CIOs report a shift in internal client attitude toward IT which, combined with the effects of budgetary cuts, is leading to a shift in the role of the CIO from IT service provider to business integrator. The description of what this sample of the industry actually does regarding outsourcing and what this means for CIOs presents a new picture compared with the current literature on outsourcing.
Unsteady turbulence cascades.

We have run a total of 311 direct numerical simulations (DNSs) of decaying three-dimensional Navier-Stokes turbulence in a periodic box with values of the Taylor length-based Reynolds number up to about 300 and an energy spectrum with a wide wave-number range of close to -5/3 power-law dependence at the higher Reynolds numbers. On the basis of these runs, we have found a critical time when (i) the rate of change of the square of the integral length scale turns from increasing to decreasing, (ii) the ratio of interscale energy flux to high-pass filtered turbulence dissipation changes from decreasing to very slowly increasing in the inertial range, (iii) the signature of large-scale coherent structures disappears in the energy spectrum, and (iv) the scaling of the turbulence dissipation changes from the one recently discovered in DNSs of forced unsteady turbulence and in wind tunnel experiments of turbulent wakes and grid-generated turbulence to the classical scaling proposed by G. I. Taylor [Proc. R. Soc. London, Ser. A 151, 421 (1935)1364-502110.1098/rspa.1935. 0158] and A. N. Kolmogorov [Dokl. Akad. Nauk SSSR 31, 538 (1941)]. Even though the customary theoretical basis for this Taylor-Kolmogorov scaling is a statistically stationary cascade where large-scale energy flux balances dissipation, this is not the case throughout the entire time range of integration in all our DNS runs. The recently discovered dissipation scaling can be reformulated physically as a situation in which the dissipation rates of the small and large scales evolve together. We advance two hypotheses that may form the basis of a theoretical approach to unsteady turbulence cascades in the presence of large-scale coherent structures.
Provincial Household Food Demand in Pakistan

In developing countries of the world, the pattern of food consumption is usually used as a benchmark for measuring the living standard of people. This paper examines and compares the food expenditure pattern of households across provinces in Pakistan using 2011-12 household integrated economic survey(HIES) data. The study used the linear approximate almost ideal demand system (LA-AIDS) to estimate food demand elasticities. The patterns of food consumption and expenditure for eight food groups: wheat flour, rice, dairy, pulses, meats, fruits and vegetables, cooking oil and other foods are examined. The study observed differences in household consumption patterns across provinces. The estimated results show that all food groups have negative own price elasticities and are consistent with economic theory. All the expenditure elasticities are positive and significant indicating that all food groups are normal. The expenditure elasticities estimated show that dairy and meats are luxury foods in all provinces, while wheat flour, pulses, cooking oil, and other foods are necessities in the diet of the Pakistani households. In all provinces, a household spends most of its food expenditure on dairy products, wheat flour, cooking oil, fruit and vegetables. The estimates suggest that policymakers in Pakistan should ensure and monitor the availability of these essential food items in order to reduce undernourishment and food insecurity in the country.
Comparison of actuation methods for wake control in wind plants

In recent research, cooperative wind turbine control strategies have been proposed to optimize overall performance of wind plants by taking into account the aerodynamic interaction effects that the wind turbines have on each other through their wakes. Wind plant control strategies have different ways of using the control degrees of freedom (DOFs) of the turbine. Conventional control DOFs of a wind turbine are the pitch angles of the blades, the generator torque, and the yaw angle of the rotor. In most wind plant control approaches in literature, the generator torque and/or blade pitch control DOF is used to affect the wake velocity deficit (referred to as axial-induction-based control). In recent studies, an alternative control method was used, in which the direction of the wake is changed using the yaw DOF such that the overlap of the wake with downstream rotors is avoided or reduced (wake redirection control). In this paper, we present a high-fidelity, computational fluid dynamics simulation case study, in which the potential of both control methods is compared, in terms of their effect on power production of a two-turbine setup. For the flow conditions and turbine considered in the case study, wake-redirection control is shown to have a larger potential to improve wind plant energy production than axial-inductionbased control. An additional analysis shows that causes for the difference in potential are wake expansion and meandering.
Post-silking Factor Consequences for N Efficiency Changes Over 38 Years of Commercial Maize Hybrids

Hybrid selection in maize (Zea mays L.) over the decades has increased post-silking dry matter (PostDM) and nitrogen (PostN) accumulation, often with an accompanying increase in one or more N use efficiency (NUE) metrics such as partial factor productivity (PFP), N conversion efficiency (NCE), and N internal efficiency (NIE). More certainty on the underlying mechanisms of how PostDM and PostN changes over time have contributed to NUE gains or losses in modern-era hybrids can only be realized by directly comparing hybrids of different eras in the context of production-system-relevant management systems. A two-year and two-location field study was conducted in Indiana with two N rates (55 and 220 kg N ha−1), three plant densities (54,000, 79,000, and 104,000 plants ha−1) and eight commercial hybrids that were released by a single seed company from 1967 to 2005. The main treatment effects of N rate, density, and hybrid dominated the PostDM and PostN responses, and there were no significant two-way or three-way interactions. Total dry matter at maturity gains averaged 80 kg ha−1 year−1 of hybrid release when averaged over locations, plant densities and N rates. Total N contents at maturity increased 0.68 kg ha−1 year−1, primarily due to annual increases in grain N content (0.8 kg ha−1 year−1). Post-silking N uptake rate increased 0.44 kg ha−1 year−1 for these era hybrids in more favorable production site-years. Slopes of grain N concentration increases per unit PostN gain were similar for all hybrids. Gains in average PFP over time were considerably higher at the low N rate (0.9 kg ha−1 year−1) than at the high N rate (0.3 kg kg−1 year−1). Hybrid gains in NIE were evident from 1967 to 1994, but not thereafter. The low N rate and higher plant densities also increased relative NIE and NCE values, but without hybrid interactions. There was no consistent trend of NIE or NCE gains in these hybrids primarily because grain and whole-plant N concentrations didn't decline over the decades at either N rate, and because NIE and NCE were often plant-density dependent.
Breeding origin and migration pattern of dunlin (Calidris alpina) revealed by mitochondrial DNA analysis

The large‐scale migration of birds has been studied extensively by recoveries of ringed birds. However, there is very little ringing data from the arctic breeding grounds of waders. Here, the migration pattern of the dunlin, Calidris alpina, is studied with population genetic markers, using haplotype frequencies to estimate the breeding origin of migrating and wintering populations. Polymerase chain reaction (PCR) and restriction analysis of DNA from the mitochondrial control region was used to study the breeding origins of morphologically similar winter populations in the western Palaearctic, and to describe the population structure of the dunlin during winter. Also migrating dunlin from various stopover sites in Europe, Africa and Asia, were analysed with respect to their mitochondrial DNA (mtDNA) haplotypes. The genetic markers clearly show that the dunlin has a parallel migration system, with populations breeding in the western Palaearctic wintering mainly in the western part of the wintering range, and dunlin populations breeding further east wintering further east. The results also show that the distance between breeding and wintering area increases eastwards in this region.
Effect of noninvasive low intensity ultrasound on bone growth into porous‐coated implants

Noninvasive low intensity ultrasound has been shown to be an effective means of accelerating bone fracture healing in both animal and clinical studies. An in vivo canine study was designed to determine if noninvasive low intensity ultrasound could influence the rate and extent of bone growth into porous‐coated implants. Twenty‐two pairs of fully porous transcortical implants were inserted bilaterally into the femora of 12 dogs. In each dog, one femur served as a control and the other was subjected to daily ultrasound stimulation for 2, 3, or 4 weeks. Overall, the ultrasound‐stimulated implants demonstrated an 18% increase in bone ingrowth compared with their contralateral controls (p = 0.02). Noninvasive low intensity ultrasound had its greatest effect in the first 2–3 weeks of stimulation. At 2 and 3 weeks, the ultrasound‐stimulated implants showed 21 and 16% more ingrowth than their respective contralateral controls. Because noninvasive low intensity ultrasound had a positive effect on bone ingrowth in this experimental investigation, further research is suggested to assess the clinical potential for application to noncemented porous‐coated total joint replacements.
Intuition: an important tool in the practice of nursing.

AIM The aim of the study reported here was to evaluate the role of intuition, to examine nurses' understanding of intuition and their perceptions of their use of intuition, and to assess the impact of intuition on nursing practice. BACKGROUND When we read the dictionary definition of intuition, we have a sense of the meaning but there is also a sense of something still not quite defined. Yet we instinctively know what intuition is. That is, of course, an example of intuition in itself: an understanding of the concept based on our feelings, knowledge and experience. Intuition is a concept neither clearly articulated nor adequately theorized in nursing. There is evidence to suggest that practising nurses use intuition and that its use can change outcomes for patients. Because of its influence on patient well being, it needs to be recognized as an important tool in the practice of nursing. The very nature of intuition determines that there will be little agreement on a precise definition and little empirical evidence to support its existence or worth. Neither of these issues detracts from the fact that intuition is an important part of nursing. METHODS Grounded theory was used as the overarching theoretical and methodological framework for this study. Using focus group interviews and the Delphi survey technique, data were collected from 262 Registered Nurses who volunteered to take part in the study. FINDINGS The theory that emerged from this study provides nurses with a way of articulating their understanding of intuition and their perceptions of its use in nursing practice. CONCLUSIONS Intuition is not some mystical power that appears from nowhere, with no rational explanation or basis. The findings from this study show that it is a product of the synergy that occurs as a result of the interaction of a number of factors.
Dynamic feature extraction of coronary artery motion using DSA image sequences

This paper aims to define and describe features of the motion of coronary arteries in two and three dimensions, presented as geometrical parameters that identify motion patterns. The main left coronary artery centerlines, obtained from digital subtraction angiography (DSA) image sequences, are first reconstructed. Thereafter, global and local motion features are evaluated along the sequence. The global attributes are centerline and point trajectory lengths, displacement amplitude, and virtual reference point, while local attributes are displacement direction, perpendicular/radial components, rotation direction, and curvature and torsion. These kinetic features allow the authors to obtain a detailed quantitative description of the displacements of arteries' centerlines, as well as associated epicardium deformations. The authors' modeling of local attributes as quasi-homogeneous on a segment analysis, enables them to propose a novel numeric to symbolic image transformation, which provides the required facts for knowledge-based motion interpretation. Experimental results using real data are consistent with cardiac dynamic behavior.
Repeated Assessment of Cognition in Children and the Measurement of Performance Change

There is limited understanding of the problems associated with repeated neuropsychological assessment in children, including the statistics used to guide decisions about cognitive change. This study investigated the utility of a computerized assessment battery that was specifically designed for the repeated assessment of cognitive function in children. Eighty-seven participants aged 8 to 12 years completed the battery four times within a 2-hour testing session. The results support the application of this assessment battery for measuring cognitive change in children. A novel method for calculating measurement error is employed, and its use in the detection of cognitive change in individual children is discussed. An estimate of the measurement error within each of the tests is provided, and recommendations are made regarding the application of this assessment battery for measuring cognitive change in children.
Adipogenic differentiation of scaffold-bound human adipose tissue-derived stem cells (hASC) for soft tissue engineering

Adipose tissue engineering, instead of tissue substitution, often uses autologous adipose tissue-derived stem cells (hASC). These cells are known to improve graft integration and to support neovascularization of scaffolds when seeded onto biomaterials. In this study we thought to engineer adipose tissue using scaffold-bound hASC, since they can be differentiated into the adipocyte cell lineage and used for soft tissue regeneration. We show here by microscopy and gene expression of the peroxysome proliferator-activated receptor gene (PPARγ2) that hASC growing on polypropylene fibrous scaffolds as well as on three-dimensional nonwoven scaffolds can be turned into adipose tissue within 19 days. Freshly isolated hASC displayed a higher differentiation potential than hASC cultured for eight passages. In addition, we proved a modified alginate microcapsule to directly induce adipogenic differentiation of incorporated hASC. The results may help to improve long-term success of adipose tissue regeneration, especially for large-scale soft tissue defects, and support the development of cell–scaffold combinations which can be shaped individually and directly induce the adipogenic differentiation of incorporated hASC at the site of implantation.