Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relation Between Relative Order Imbalance and Intraday Futures Returns: An Application of the Quantile Regression Model to Taiwan

Adopting the quantile regression model, this paper describes the positive relation between relative order imbalance and intraday futures returns. The positive connection is relatively stronger for lower quantiles of intraday futures returns than for higher quantiles. However, the connection vanishes within 30 minutes. The results reflect the compensation of the uncertainty and the absence of liquidity for relatively lower returns in the Taiwan futures market. Furthermore, this paper finds evidence supporting an L-shaped pattern for intraday futures returns.
Optimal Grazing Termination Date for Dual-Purpose Winter Wheat Production

Dual-purpose winter wheat (fall-winter forage plus grain) production is an important economic enterprise in the southern Great Plains. Grazing termination to enable grain production is a critical decision. The objective is to determine the optimal grazing termination date for dual-purpose wheat. The value of knowing the occurrence of first hollow stem (FHS), a wheat growth threshold for grazing termination, is also determined. Results indicate that for most price situations grazing should be terminated at or before FHS. Marginal wheat returns from extended grazing were negative and the value of FHS information ranges from $1.50 to $10 per acre.
Differentiating Self-Neglect as a Type of Elder Mistreatment: How Do These Cases Compare to Traditional Types of Elder Mistreatment?

ABSTRACT Official estimates suggest that self-neglect is the most common type of elder mistreatment. Interestingly, very few researchers have empirically assessed self-neglect as a type of elder mistreatment. In the current study, attention is given to how self-neglect cases handled by adult protective services agencies compare to other types of elder mistreatment. Comparisons are made between the needs of self-neglect clients and other protective services clients as well as the role of stress in the different types of abuse. Findings suggest that self-neglect clients are less likely to need help with certain functional activities. In addition, those who are married and those who have completed fewer years of education are less likely to be labeled as experiencing self-neglect. City differences in rates of self-neglect were also found. Not surprisingly, self-neglect clients were more likely than other protective services clients to refuse services. Implications are provided.
Population exposure–response model to support dosing evaluation of ixekizumab in patients with chronic plaque psoriasis

Ixekizumab (LY2439821), a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody that selectively binds and neutralizes interleukin (IL) 17A has demonstrated efficacy in the treatment of psoriasis. A population pharmacokinetics–pharmacodynamics model was developed using NONMEM 7.2 to describe the temporal relationship between ixekizumab concentrations and absolute Psoriasis Area and Severity Index (PASI) scores from a phase 2 dose‐finding study in chronic plaque psoriasis. The objective was to inform dose‐selection for further development. The primary endpoint, PASI 75 (75% or greater improvement from baseline PASI score) was then derived from each individual's absolute PASI score. The population pharmacokinetics of ixekizumab was characterized by a two‐compartment model, while the exposure–response relationship was characterized using an indirect response model that described the pharmacological effects of ixekizumab and placebo in the form of inhibition of the formation of psoriatic skin lesions. PASI 75 responder status at the Week 12 primary endpoint was found to be a significant covariate on the concentration producing half maximal effect (EC50). While the results suggested patient may have different levels of sensitivity to ixekizumab, it is possible that nonresponder patients assigned to lower doses of ixekizumab may potentially become responders to ixekizumab if given doses that yield adequate exposures.
Transfer and translation of policy

The past two decades have seen a wealth of papers on policy diffusion and policy transfer. In the first half, this paper reviews some of the trends in the literature by looking backwards to the political science diffusion literature, and forwards to the expanding multi-disciplinary social science literatures on policy ‘learning’, ‘mobilities’ and ‘translation’ which qualify many of the rationalist assumptions of the early diffusion/transfer literatures. These studies stress the complexity of context that modifies exports of policy and the need for interpretation or experimentalism in the assemblage of policy. The second half of the paper focuses on role of international organisations and non-state actors in transnational transfer in the spread of norms, standard setting and development of professional communities or networks that promote harmonisation and policy coordination. The ‘soft’ transfer of ideas and information via networks whether they be personal, professional or electronic is rapid and frequent. It is rather more infrequent to see such ideas structure governance and become institutionalised. Knowledge transfer is more extensive than policy transfer.
Auditor Choice in Politically Connected Firms

We extend recent research on the links between political connections and financial reporting by examining the role of auditor choice. Our evidence that public firms with political connections are more likely to appoint a Big 4 auditor supports the intuition that insiders in these firms are eager to improve accounting transparency to convince outside investors that they refrain from exploiting their connections to divert corporate resources. In evidence consistent with another prediction, we find that this link is stronger for connected firms with ownership structures conducive to insiders seizing private benefits at the expense of minority investors. We also find that the relation between political connections and auditor choice is stronger for firms operating in countries with relatively poor institutional infrastructure, implying that tough external monitoring by Big 4 auditors becomes more valuable for preventing diversion in these situations. Finally, we report that connected firms with Big 4 auditors exhibit less earnings management and enjoy greater transparency, higher valuations, and cheaper equity financing.
How Does Prior Information Affect Analyst Forecast Revisions

This study investigates how observable prior information affects individual analysts’ earnings forecast revisions. Following Stickel (1990), it first examines how new information observed by Korean analysts and uncertainty in the analysts’ current forecast affect the analysts’ forecast revision. Then, this study extends the prediction model by examining how characteristics of new information (positive vs. negative change in consensus forecast) and the characteristics of the analysts’ current forecast (higher vs. lower than the mean forecast) affect their forecast revision. The empirical results show that the individual analyst revision, the change in consensus forecast, and the cumulative stock returns are positively related whereas the revision and the deviation of the analyst’s current forecast from the consensus forecast are negatively related. Results also show more sensitive reactions to consensus change when analysts observe a negative consensus change. In addition, analysts’ reaction to a negative consensus change is greater when their current forecast is greater than the prior mean forecast. These results suggest that analysts learn from market expectation changes and incorporate new information into their new forecasts.
Thai Cultural Aspects in English Language Textbooks in a Thai Secondary School

This study explores Thai cultural aspects in six English language textbooks called World Wonders 1 and My World Series 2 - 6 used at a secondary school located in the district of Sai Yok, Kanchanaburi province, Thailand. The findings reveal that Thai culture in these textbooks can be categorized into five main aspects, which are 1) products (rice, sepak takraw, tuk-tuk); 2) practices (cooking, eating and Thai boxing); 3) persons (Siamese king, Vanessa-Mae); 4) perspectives (Thai people, traffic congestion, food, weather, and Thai language); and 5) places (tourist sites such as Phi Phi Island, Phuket, Bangkok, Chiang Mai, and Lopburi). This study potentially offers some possible implications for English language textbook development that is culturally appropriate for language teachers and learners at a secondary school in Thailand.
Dorsal pancreas agenesis in N-cadherin- deficient mice.

Members of the cadherin family of cell adhesion molecules are thought to be crucial regulators of tissue patterning and organogenesis. During pancreatic ontogeny N-cadherin is initially expressed in the pancreatic mesenchyme and later in pancreatic endoderm. Analysis of N-cadherin-deficient mice revealed that these mice suffer from selective agenesis of the dorsal pancreas. Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme.
Diurnal Variation of the Peripheral Cholinergic Antiinflammatory Function in Mice

Cholinergic antiinflammatory (CAI) pathway functions importantly in inflammation via α7 nicotinic acetylcholine receptors (α7nAChR). The present work tested circadian rhythm in peripheral CAI activity and validities of CAI activity and glucocorticoids in chronotherapy for lipopolysaccharide (LPS)‐induced shock.
The impact of international financial reporting standards: does size matter?

Purpose – This study seeks to examine the impact of Australian equivalents to international financial reporting standards (A‐IFRS) on the accounts of small‐, medium‐ and large‐sized firms.Design/methodology/approach – For 135 listed Australian entities, the half‐yearly accounts ended 30 June 2005 are examined to identify the effects of A‐IFRS. Data are gathered on the change in major balance sheet and income statement elements, the major reconciling items and earnings variability.Findings – Findings show that more than half of small firms have no change in net income or equity from A‐IFRS, and that there is an increase in the number of adjustments to net income and equity with firm size. The study also finds that A‐IFRS has increased net income for small‐ and medium‐sized firms. Equity has increased (decreased) under A‐IFRS for small (large) firms. Small firms experience higher earnings variability than medium‐sized or large firms under A‐IFRS.Research limitations/implications – The sample is limited to 3.
Love in the Time of Neo-Liberalism

Households around the world have shifted structurally from a breadwinner/homemaker model to dual-income earning arrangements. What this trend means for marital power has been a contested issue among scholars. Most studies suggest that household power is determined by a complex interplay between each spouse's economic contributions to the household and existing gender norms. Few scholars, however, have examined how this interplay is worked out under particular political-economic conditions. Responding to the dearth of research on the developing world in this area, the author examines a community in Costa Rica where neo-liberal economic restructuring has led to an increase in women's informal work and a decrease in men's income-earning power. Drawing from ethnographic and interview data on married life in Costa Rica, the author analyzes the effect that these trends have on marital power and the division of household labor. The author argues that changing economic circumstances may blur the traditional gender boundaries in Costa Rican households but they do not necessarily erase them.
Does Export Promotion Increase Economic Growth? Some Cross-Section Evidence

This article is concerned with the empirical link between exports and economic growth. Its core objectives are to attempt control for structural features that determine "export orientation" in order to derive an index of export promotion that captures policy effects only, and then to test whether or not this index is a determinant of growth. The empirical work presented casts doubt on the overall validity of the export-led development hypothesis. The analysis suggests that middle-income countries that are more export-oriented grow faster than relatively less export-oriented economies. For low- and high-income countries, however, export promotion does not have any significant impact on economic growth.
The Production of Human Capital and the Life Cycle of Earnings

T HE application of capital theory to decisions on individual improvement, and in particular improvement of earning capacity, has provided a framework for the understanding of many aspects of observed behavior regarding education, health, occupational choice, mobility, etc., as rational investment of present resources for the purpose of enjoying future returns. The formulation by Friedman and Kuznets (1945) and the significant development of the theory by Becker (1962, 1964) and Mincer (1958, 1962) provided a novel view of the life cycle of earnings by linking it to the time profile of investment in human capital: People make most of their investments in themselves when they are young, and to a large extent by foregoing current earnings. Observed earnings are therefore relatively low at early years, and they rise as investment declines and as returns on past investments are realized. The main reason why investment is undertaken mostly by the young is that they have a longer period over which they can re-
Juvenile Hormone Regulates Vitellogenin Gene Expression through Insulin-like Peptide Signaling Pathway in the Red Flour Beetle, Tribolium castaneum*

Background: Juvenile hormone (JH) and nutrition signals regulate vitellogenin (Vg) synthesis in insects. Results: Expression of genes coding for insulin-like peptides, insulin receptor, Akt, and FOXO is required for transduction of JH and nutrition signals. Conclusion: JH and nutritional signals function through insulin-like peptide signaling pathway. Significance: These studies illustrate the complex nature of endocrine regulation of reproduction. Our recent studies identified juvenile hormone (JH) and nutrition as the two key signals that regulate vitellogenin (Vg) gene expression in the red flour beetle, Tribolium castaneum. Juvenile hormone regulation of Vg synthesis has been known for a long time in several insects, but the mechanism of JH action is not known. Experiments were conducted to determine the mechanism of action of these two signals in regulation of Vg gene expression. Injection of bovine insulin or FOXO double-stranded RNA into the previtellogenic, starved, or JH-deficient female adults increased Vg mRNA and protein levels, thereby implicating the pivotal role for insulin-like peptide signaling in the regulation of Vg gene expression and possible cross-talk between JH and insulin-like peptide signaling pathways. Reduction in JH synthesis or its action by RNAi-mediated silencing of genes coding for acid methyltransferase or methoprene-tolerant decreased expression of genes coding for insulin-like peptides (ILPs) and influenced FOXO subcellular localization, resulting in the down-regulation of Vg gene expression. Furthermore, JH application to previtellogenic female beetles induced the expression of genes coding for ILP2 and ILP3, and induced Vg gene expression. FOXO protein expressed in baculovirus system binds to FOXO response element present in the Vg gene promoter. These data suggest that JH functions through insulin-like peptide signaling pathway to regulate Vg gene expression.
Stable, conserved outer membrane epitope of strains of Haemophilus influenzae biogroup aegyptius associated with Brazilian purpuric fever

Brazilian purpuric fever is a rapidly fatal childhood disease associated with a clonal strain of Haemophilus influenzae biogroup aegyptius. We describe a conserved, surface-exposed epitope present on 95% of H. influenzae biogroup aegyptius isolates that are associated with Brazilian purpuric fever. This epitope, defined by reaction with the monoclonal antibody 8G3, is on or associated with the 48-kDa heat-modifiable P1 protein. The epitope is absent on strains of H. influenzae biogroup aegyptius that are not associated with Brazilian purpuric fever but is present on one strain of H. influenzae biotype II. None of 81 other Haemophilus strains tested reacted with 8G3. The sensitivity and specificity of the 8G3 monoclonal antibody in detecting Brazilian case-clone strains of H. influenzae biogroup aegyptius associated with Brazilian purpuric fever are 95 and 99%, respectively. Immunoelectron microscopy revealed that the epitope is surface exposed, and N-terminal amino acid sequencing of an 8G3-reactive P1 protein from a strain of H. influenzae biogroup aegyptius showed 100% correlation with the published N-terminal amino acid sequence of a P1 protein of H. influenzae type b. The virulence of the organism in an infant rat model of bacteremia was not dependent on the expression of this epitope.
Effect of the characteristics of the purchased products in JIT purchasing implementation

JIT purchasing, like many other trends in supply management, is not applicable to just any circumstances; rather, its implementation responds to particular factors. Focusing on the characteristics of the purchased products, this paper contributes to identifying some of these factors. Seven variables – the volume, specificity, technological complexity, essentiality, fragility, variability and economic value of procured products – have been analysed and their effects on JIT purchasing implementation have been tested over a sample of 152 Spanish auto component manufacturers. In order to specify such effects, four dimensions of JIT purchasing have been distinguished: operational, relational, involvement, and quality practices. Results show that companies do not pursue the minimisation of inventory maintenance costs, but they seem to be motivated by objectives such as quality, responsiveness, innovation or minimisation of circulating capital. Thus, operational JIT purchasing practices are mainly applied to fra.
Estimating the value of natural resources under legal constraints: an application to marine resources in Sicily

In this article, we use the Contingent Evaluation methodology to develop an economic evaluation of natural resources in a protected marine area of Sicily. Assuming a nonnormal distribution for the ML estimation, the article shows that a variant of the stochastic utility model appears to capture well the dependence of the willingness to pay (WTP) on the socioeconomic characteristics of a sample of stakeholders of the natural resources in question. The estimates obtained are consistent and robust across different policy measures, no embedding or sequencing effects emerge and option values also appear to have been elicited in a consistent way. Once these values are added to the basic WTP, the income elasticities estimated fall in the range reported by other studies.
Gene polymorphisms of endothelial nitric oxide synthase and angiotensin‐converting enzyme in patients with asthma

Background: Nitric oxide, including that produced by endothelial constitutive nitric oxide synthase (ecNOS), may regulate vascular and airway tone in the lungs and may influence various aspects of airway homeostasis. Angiotensin‐converting enzyme (ACE) is expressed at high levels in the lungs and plays a role in the metabolism of angiotensin II, bradykinin, and substance P, all of which are potentially involved in the pathogenesis of asthma. An insertion‐deletion polymorphism of the ACE gene has been shown to be associated with enzyme activity levels of ACE. To examine the possible involvement of the ecNOS and/or ACE genes as the genetic basis of bronchial asthma, we investigated whether there was any association between bronchial asthma and polymorphisms of the ecNOS and/or ACE genes.
The outcome of the parasitic process initiated by Leishmania infantum in laboratory mice: a tissue-dependent pattern controlled by the Lsh and MHC loci.

Human visceral leishmaniasis is mainly due to intracellular protozoan parasites of the Leishmania donovani complex, i.e., L. donovani and L. infantum (or L. chagasi). A mouse model has been established to monitor 1) the parasitic process initiated by L. infantum in three tissues they invade, and 2) parameters of the acquired immune response they trigger. Mice congenic at the Lsh locus and mice of inbred strains differing at the MHC locus have been inoculated by the i.v. route with L. infantum. The parasitic process has been evaluated by the follow-up of the parasitic load in the liver, the spleen, and, for the first time, in the bone marrow using a very sensitive limiting dilution assay. As previously established for L. donovani, the early outcome of L. infantum is also under the control of the Lsh locus in the liver; genes of the MHC complex are involved in the development of the subsequent acquired immune response. "Cure" or "noncure" haplotypes are the same for the two species of Leishmania; as far as the cure haplotype is concerned, whatever the tissues being screened, the parasites are never totally cleared, although the liver is the tissue in which the best parasite load reduction is achieved. Through immunostaining, it was established that sialoadhesin-positive stromal bone marrow macrophages contain parasites; such long-lived mononuclear phagocytes could be the host cells where the parasite can find "safe targets" unreactive to the dominant effector immune mechanism triggered by the replicative stage of the parasites.
Applying modern portfolio theory to upstream investment decision making

Nobel laureate Harry Markowitz provided investors with a framework to optimize risk and return of their portfolios of stocks and bonds. With a small portfolio of upstream investments as an example, this paper demonstrates how E&P companies can use similar portfolio-optimization methods to determine a mix of projects that provides the minimum risk for a given level of return. Contrasting this portfolio with investments selected by use of traditional capital-allocation techniques, the paper demonstrates how modern portfolio theory provides management with a superior setting for allocating capital by illuminating risk at the portfolio level.
The Distributive Effect of Expanding the Sales Tax

This article examines the distributive effect of expanding the Minnesota sales tax Abstract base to include additional consumption items. Two indexes, Kakwani and the Suits, are calculated for the existing sales tax base and expansion options. The indexes consistently indicate that the existing tax base is regressive, as are the major base expansion items. Effective tax rates indicate that expanding the sales tax will widen the burden gap between low-income and high-income taxpayers. The aggregate property of the Kakwani and Suits indexes is used to examine the overall distributive effect of sales tax and other tax systems.
Fan Substitution and the 2004-05 NHL Lockout

This study estimates fan substitution in sports using the 2004-05 National Hockey League (NHL) season-long lockout as a natural experiment. The authors find that NHL fans substitute minor league and junior league hockey for the NHL. Because this is not due to a change in the price of a substitute good, the findings point to pure substitution effects without income effects. The findings have implications for future work on fan demand, especially for those studying habit and loyalty, or sports policy.