Miracle-dz/UniFAR-FTUs huggingface dataset:
Does the minor trauma during pregnancy have any effect on perinatal outcome

Objective: Women having major trauma during pregnancy are at increased risk for both maternal and fetal morbidity. However, the association between minor trauma and adverse perinatal outcomes is still unknown. Therefore, we aimed to analyze the incidence of minor trauma in pregnancy and effect on the outcomes of pregnancy. Methods: The data of patients, who were admitted to the emergency service of Etlik Zubeyde Hanim Women’s Health Training and Research Hospital between January 2013 and December 2014, were evaluated. A total of 283 patients (0.3%), who had minor trauma during pregnancy, were included in the study. Demographic and obstetric data were analyzed with descriptive statistics. Additionally, antenatal complications and pregnancy outcomes were evaluated in 188 patients, who were followed during pregnancy and delivered their babies at our hospital Results: During the study period, of 105,727 women who were admitted to the emergency service of our hospital, 283 (0.3%) had minor trauma during pregnancy. The causes of minor trauma, in order of frequency, included home accidents (81.3%), domestic violence (9.9%) and traffic accidents (8.8%). Preterm delivery has been the most frequently antenatal complication observed in these patients (15.4%). Conclusion: Home accidents and domestic violence are the most common causes of minor trauma during pregnancy, and the patients are particularly at risk during the second trimester. The patients must be cautioned regarding the risk of preterm delivery and advised to attend regular pregnancy follow-up visits due to the fact that these patients have a higher risk of preterm delivery. Key words: Minor trauma, pregnancy, antenatal complication, preterm delivery
Comportamiento clínico de la colitis ulcerosa crónica inespecífica en pacientes del CMN 20 de Noviembre, ISSSTE , y comparación con la bibliografía americana

Background: Previous studies done in patients affected with inflammatory bowel disease (IBD) have suggested the presence of genetic and environmental factors influencing the clinical behavior of this disease. aIM: This work intended to evaluate, descriptively and retrospectively, the clinical behavior and treatments on a group of Mexican patients affected by IBD and compare our results with results published in similar studies carried out in mexico-american patients, analyzed in other countries and determine differences between results. Materials and methods: We did a descriptive and retrospective analysis in 85 patients diagnosed as Nonspecific Ulcerative Colitis and Chron’s Disease. We analyzed: Method of diagnosis, extension of disease, medical and/or surgical treatment and mortality. We obtained results from Mexican population and compared them with results obtained from Mexico-american population published elsewhere. results: We obtained a population of 85 patients, 57.6% female and 42.3% male. Most of them were affected by ulcerative colitis. We found only familial history of disease in 2 cases. In relationship to extension of disease, we found a higher prevalence of left-sided colitis in Mexican patients than in mexico-american population; however, the frequency of proctitis in both groups was similar. Related to medical treatment, we found that Mexican population was treated in a higher frequency with biological therapeutic agents than mexico-american patients. Related to surgical treatment, we did not find statistical differences between groups. Conclusions: Our study, which describes the principal characteristics and clinical behavior of IBD in Mexican population, shows that similar genetic and cultural population, in different environmental conditions, show slight differences, related principally left-sided colitis, higher mortality, and higher usage of biological agents. Our results support the role of environment on clinical characteristics of IBD.
Normalizing the Abnormal: Do Antipsychotic Drugs Push the Cortex Into an Unsustainable Metabolic Envelope?

Abstract The use of antipsychotic medication to manage psychosis, principally in those with a diagnosis of schizophrenia or bipolar disorder, is well established. Antipsychotics are effective in normalizing positive symptoms of psychosis in the short term (delusions, hallucinations and disordered thought). Their long-term use is, however, associated with side effects, including several types of movement (extrapyramidal syndrome, dyskinesia, akathisia), metabolic and cardiac disorders. Furthermore, higher lifetime antipsychotic dose-years may be associated with poorer cognitive performance and blunted affect, although the mechanisms driving the latter associations are not well understood. In this article, we propose a novel model of the long-term effects of antipsychotic administration focusing on the changes in brain metabolic homeostasis induced by the medication. We propose here that the brain metabolic normalization, that occurs in parallel to the normalization of psychotic symptoms following antipsychotic treatment, may not ultimately be sustainable by the cerebral tissue of some patients; these patients may be characterized by already reduced oxidative metabolic capacity and this may push the brain into an unsustainable metabolic envelope resulting in tissue remodeling. To support this perspective, we will review the existing data on the brain metabolic trajectories of patients with a diagnosis of schizophrenia as indexed using available neuroimaging tools before and after use of medication. We will also consider data from pre-clinical studies to provide mechanistic support for our model.
The Impacts of Green Innovation Input and Channel Service in a Dual-Channel Value Chain

This paper constructs a dual-channel value chain composed of one altruistic manufacturer and one altruistic retailer, where the manufacturer makes green innovation input for green products and sells its green products to its customers through both the direct channel and the traditional channel, the retailer provides channel service for customers and sells green products through the traditional channel. We consider two scenarios in which the manufacturer and the retailer make decentralized and centralized decisions, respectively. We develop two dynamic game models for the two scenarios and analyze the dynamic behaviors of the two dynamic game models using bifurcation diagram, LLE (largest Lyapunov exponent) and attraction of basin, etc. We find that the stability region in decentralized decision model is greater than that of centralized decision, and narrow with increase of service value, green innovation input. In the decentralized decision model, the stability of the system decreases with the altruistic behavior increasing. With the price adjustment speed increasing, the dual-channel green value chain system enters into chaotic state through flip bifurcation or N-S bifurcation. In the stable state, the manufacturer and the retailer can obtain the maximum utility with the appropriate value of green innovation input. In the chaotic state, the utilities of the manufacturer and retailer are greatly affected and significantly reduced. This study will provide good guidance for sustainable development decision-making of dual-channel green value chain.
Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke

Ischemic stroke (IS) is multifactorial causation combining with traditional cardiovascular disease (CVD) and genetic risk factors. Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of IS remain incompletely understood. We aimed to assess individual and joint effects for IS risk by weighted genetic risk score (wGRS) from these three genes and traditional CVD risk factors. A case-control study including 500 cases with IS and 500 stroke-free healthy controls frequency-matched with cases by age and sex was conducted. The wGRS was a weighted average of the number of risk genotype across selected SNPs from MMP-7, MMP-8 and MMP-26. Multivariate logistic regression models were used to analyze the relationship between wGRS and risk of IS. A wGRS in the second tertile was associated with a 1.5-fold increased risk of IS compared with the lowest tertile after adjusting for traditional CVD risk factors. Compared to subjects with low genetic and low modifiable CVD risk, those with high genetic and high modifiable CVD risk had the highest risk of IS (adjusted-OR = 5.75). In conclusion, higher wGRS was significantly associated with an increased risk for IS. A significant interaction between genetic and traditional CVD risk factors was also found on the risk of IS.
The Digital Addiction Scale for Children: Development and Validation

Researchers worldwide have developed and validated several scales to assess various forms of adults' digital addiction. The urge for some of these scales found support in World Health Organization's inclusion of gaming disorder as a mental health condition in its eleventh revision of the International Classification of Diseases in June 2018. Additionally, several studies have shown that children are starting to use digital devices (DDs) (e.g., tablets and smartphones) at a very young age, including playing video games and engaging in social media. Consequently, the need for early detection of the risk of digital addiction among children is becoming more of a necessity. In the present study, the Digital Addiction Scale for Children (DASC)-a 25-item self-report instrument-was developed and validated to assess the behavior of children 9 to 12 years old in association with DD usage, including video gaming, social media, and texting. The sample comprised 822 participants (54.2 percent males), from grade 4 to grade 7. The DASC showed excellent internal consistency reliability (α = 0.936) and adequate concurrent and criterion-related validities. The results of the confirmatory factor analysis showed that the DASC fitted the data very well. The DASC paves the way to (a) help in early identification of children at risk of problematic use of DDs and/or becoming addicted to DDs and (b) stimulate further research concerning children from different cultural and contextual settings.
Endometrial Cancer Stem Cells: Role, Characterization and Therapeutic Implications

Endometrial cancer (EC) is the most frequent gynecological cancer. In patients with relapsed and advanced disease, prognosis is still dismal and development of resistance is common. In this context, endometrial Cancer Stem Cells (eCSC), stem-like cells capable to self-renewal and differentiation in mature cancer cells, represent a potential field of expansion for drug development. The aim of this review is to characterize the role of eCSC in EC, their features and how they could be targeted. CSC are involved in progression, invasiveness and metastasis (though epithelial to mesenchimal transition, EMT), as well as chemoresistance in EC. Nevertheless, isolation of eCSC is still controversial. Indeed, CD133, Aldheyde dehydrogenase (ALDH), CD117, CD55 and CD44 are enriched in CSCs but there is no universal marker nowadays. The most frequently activated pathways in eCSC are Wingless-INT (Wnt)/β-catenin, Notch1, and Hedghog, with a high expression of self-renewal transcription factors like Octamer binding transcription factor 4 (OCT), B Lymphoma Mo-MLV Insertion Region 1 Homolog (BMI1), North American Network Operations Group Homebox protein (NANOG), and SRY-Box 2 (SOX2). These pathways have been targeted with selective drugs alone or in combination with chemotherapy and immunotherapy. Unfortunately, although preclinical results are encouraging, few clinical data are available.
Influence of Nanostructuration on PbTe Alloys Synthesized by Arc-Melting

PbTe-based alloys have the best thermoelectric properties for intermediate temperature applications (500–900 K). We report on the preparation of pristine PbTe and two doped derivatives (Pb0.99Sb0.01Te and Ag0.05Sb0.05Pb0.9Te, so-called LAST18) by a fast arc-melting technique, yielding nanostructured polycrystalline pellets. XRD and neutron powder diffraction (NPD) data assessed the a slight Te deficiency for PbTe, also yielding trends on the displacement factors of the 4a and 4b sites of the cubic Fm-3m space group. Interestingly, SEM analysis shows the conspicuous formation of layers assembled as stackings of nano-sheets, with 20–30 nm thickness. TEM analysis shows intra-sheet nanostructuration on the 50 nm scale in the form of polycrystalline grains. Large numbers of grain boundaries are created by this nanostructuration and this may contribute to reduce the thermal conductivity to a record-low value of 1.6 Wm−1K−1 at room temperature. In LAST18, a positive Seebeck coefficient up to 600 μV K−1 at 450 K was observed, contributing further towards improving potential thermoelectric efficiency.
The Effect of Behaviour and Diet on the Rumen Temperature of Holstein Bulls

Simple Summary The use of precision technology within agriculture is growing rapidly. Rumen temperature boluses are primarily used for the detection of ill health, but also have uses in detecting estrus and the onset of parturition. Research has shown that water intake and diet can impact rumen temperature. However, little emphasis has been placed on the impact of behaviour, particularly agonistic interactions, which are common amongst young bulls. In fact, there is a clear knowledge gap surrounding the effect behaviour has on physiology, particularly core body temperature. Thus, the aim of this study is to investigate the impact of behaviour and diet on the rumen temperature of Holstein bulls, both at grass, and in a housed environment. The results from this study indicate that although significant differences in rumen temperature exist between behaviour groups, these rumen temperatures are all within the normal temperature range. Therefore, behaviour should not impact the accuracy of the detection of ill health. Furthermore, diet had no effect on rumen temperature. Abstract Rumen temperature boluses are becoming increasingly used as a means of monitoring core body temperature for the detection of ill health. However, the effect of behavior on rumen temperature is largely unknown. This research investigates the impact of behaviour and diet on the rumen temperature of Holstein bulls, both at grass, and in a housed environment. Rumen temperature was recorded at five-minute intervals using a bolus. Direct observations were conducted on young bulls in two studies (i) at grass (n = 30) and (ii) while housed (n = 32). In addition, activity monitors were attached to bulls at grass (n = 24). Within each study, diet differed by the level of concentrate supplementation. There was no effect of diet on rumen temperature. Significant differences in rumen temperature were observed between behaviour groups for bulls at grass (p < 0.001) and housed (p < 0.001). Furthermore, drinking resulted in the lowest rumen temperature (grass 35.97 °C; housed 36.70 °C). Therefore, rumen temperature is affected by behavior; however, the temperatures recorded were not outside the normal temperature range for healthy cattle.
The Cooperative Effect between Polybasic Region (PBR) and Polysialyltransferase Domain (PSTD) within Tumor-Target Polysialyltranseferase ST8Sia II.

ST8Sia II (STX) is a highly homologous mammalian polysialyltransferases (polyST), which is validated tumor-target in the treatment of cancer metastasis reliant on tumor cell polysialylation. PolyST catalyze synthesis of 2,8-polysialic acid (polySia) glycans by carrying out the activated CMP-Neu5Ac (Sia) to N- and O-linked oligosaccharide chains on acceptor glycoproteins. In this review article, we summarized the recent studies about intrinsic correlation of two polybasic domains, Polysialyltransferase domain (PSTD) and Polybasic region (PBR) within ST8Sia II molecule, and suggested that the critical amino acid residues within the PSTD and PBR motifs of ST8Sia II for polysialylation of Neural cell adhesion molecules (NCAM), which is related to ST8Sia II activity. In addition, the configurational changes of the PSTD domain due to the point mutations in the PBR or PSTD domain are also analyzed. These findings have been incorporated into Zhou's NCAM polysialylation/cell migration model, which will provide new perspectives on drug research and development related to the tumor-target ST8Sia II.
Motivating factors on performance of primary care workers in China: a systematic review and meta-analysis

Objective Although China has made remarkable progress in strengthening its primary healthcare system, lack of well-performed primary health workforce is still the bottleneck of deepening the reform. The objective of this review is to understand the current profile of Chinese primary care workers (PCWs) and their motivating factors of performance and propose targeted policy suggestions on improving their work performance. Design Systematic review. Methods A systematic search of PubMed and MEDLINE was conducted to identify articles published from January 1, 2000, to June 2, 2018. Quality assessment and data extraction for the studies closely relevant to performance of PCWs in China were conducted by two reviewers independently. A preliminary framework containing different levels of factors influencing PCWs’ motivation based on existence, growth and relatedness (ERG) theory guided the synthesis analysis. In addition, we used a random-eﬀects model to pool individual studies on job satisfaction and estimate the overall job satisfaction of PCWs. Results A total of 36 articles were included; 16 (23 882 participants) in the meta-analysis. Regarding the individual level of motivation, 3 overarching themes and 12 subthemes were developed. The subthemes of financial incentives, career advancement and work itself were frequently mentioned and have more influences on PCWs’ performance. Moreover, the healthcare system reform policies have inevitable and complex impacts on different levels of human needs, and then influences on the motivation and performance of PCWs. Meta-analysis showed that the overall job satisfaction score among PCWs was 3.30, just reaching a satisfied rating and varied in different regions. Conclusions This study suggests low work satisfaction among PCWs in China, with financial incentives and career advancement being two most important motivating factors. Eﬀorts to improve the work performance in PCWs should give priority to these motivating factors and systematically take into account the health policy’s impacts on performance of PCWs.
Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study

Background Anemia during pregnancy is a common public health problem globally and it defined as the hemoglobin concentration of less than 11 g/dl. Anemia during pregnancy has maternal and perinatal diverse consequences and it increase the risk of maternal and perinatal mortality. The aim of this study is to assess magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, South west, Ethiopia, 2018. Methods A cross-sectional study was employed on 1871 pregnant mothers from selected hospitals. All third trimester pregnant women attending antenatal care at Mizan-Tepi University Teaching Hospital, Tepi, Gebretsadik Shawo and Wacha public hospitals were included in the study. Data was entered to Epidata version 3.1 and exported to SPSS version 21 for analysis. Logistic regression analysis was carried out to identify independently associate factors at confidence interval of 95% and significance level of P-value <0.05. Result The magnitude of anemia in this study from the total study participant was 356 (19.0%). Among anemic pregnant women, 330 (92.7%), 21(5.9%) and 5(1.4%) were mild anemia, moderate anemia and severe anemia respectively. Age group 20–24 [AOR 6.28(2.40–16.42)], 25–29 [AOR = 6.38 (2.71–15.01)], 30–34 [AOR = 5.13 (2.27–11.58) and age ≥35 years [AOR = 2.53 (1.07–5.98)], educational status (read and write) [AOR 2.06, 95% CI (1.12–3.80)], gestational age(term)[AOR 1.94, 95% CI (1.27–2.96)], Caffeine (coffee and tea) and alcohol use occasionally [AOR 2.01, 95% CI (1.14–3.55)] and [AOR 2.59, 95% CI (1.49–4.52)] respectively, nutritional status (under nutrition) [AOR 3.00, 95% CI (2.22–3.97)] and family size (>6) [AOR 2.66, 95% CI (1.49–4.77)] were factors associated with anemia. Conclusion The magnitude of anemia found to be high. Age, educational status of the mother, gestational age, caffeine and alcohol use, Nutritional status and family size were factors significantly associated with anemia. To prevent adverse outcome of anemia, health care providers should work on these factors.
Strain Elastography-Targeted Biopsy: Does Prostate Volume Affect Prostate Cancer Detection?

Background The present study aimed to assess the correlation between prostate volume and prostate cancer (PCa) detection by strain elastography (SE)-guided targeted biopsy (TB) compared with conventional transrectal ultrasound (TRUS)-guided systematic biopsy (SB). Material/Methods This retrospective study enrolled 357 patients suspected to have PCa. All patients received TRUS-guided 10-core SB and SE-guided TB. The sensitivity for PCa detected by SE-guided TB was compared with that by TRUS-guided SB, in combination with prostate biopsy pathology. The correlation between the prostate volume and the detection rate of SE-guided TB was investigated. Results PCa was pathologically confirmed in 151 out of 357 patients. The by-patient detection rate of TRUS-guided SB was 72.8% (110/151). Subsequently, a further increase of 6.6% (10/151) in PCa determination was obtained by the SE-guided TB. The sensitivity of SE-guided TB for patients with prostate volume <30 ml, 30–50 ml, 51–80 ml, and >80 ml was 91.7% (44/48), 80.3% (53/66), 70.4% (19/27), and 40.0% (4/10), respectively (p=0.002). For patients with a prostate volume less than 30 ml, SE-guided TB (91.7%) had a higher sensitivity than SB (62.5%) (p<0.007). Conclusions SE-guided TB has a higher detection rate of PCa in comparison with TRUS-guided SB. There was also a negative correlation between prostate volume and SE-guided TB. Therefore, use of SE-guided TB may complement use of conventional SB, especially for patients with smaller prostate volume.
Data-driven analyses of motor impairments in animal models of neurological disorders

Behavior provides important insights into neuronal processes. For example, analysis of reaching movements can give a reliable indication of the degree of impairment in neurological disorders such as stroke, Parkinson disease, or Huntington disease. The analysis of such movement abnormalities is notoriously difficult and requires a trained evaluator. Here, we show that a deep neural network is able to score behavioral impairments with expert accuracy in rodent models of stroke. The same network was also trained to successfully score movements in a variety of other behavioral tasks. The neural network also uncovered novel movement alterations related to stroke, which had higher predictive power of stroke volume than the movement components defined by human experts. Moreover, when the regression network was trained only on categorical information (control = 0; stroke = 1), it generated predictions with intermediate values between 0 and 1 that matched the human expert scores of stroke severity. The network thus offers a new data-driven approach to automatically derive ratings of motor impairments. Altogether, this network can provide a reliable neurological assessment and can assist the design of behavioral indices to diagnose and monitor neurological disorders.