Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood and Milk Glutamine + Glutamate and Milk Composition in Lactating Holstein Cows in Semi-Arid of Brazil

Our objectives were to measure glutamine (Gln) and glutamate (Glu) concentrations in the milk and blood of lactating Holstein cows, as well as milk composition and somatic cell count (SCC) throughout different stages of lactation. Samples were collected from 21 cows in the 1st, 2nd, 3rd, 5th and 10th months of lactation. It analyzed Gln and Glu in the blood and Gln, Glu, lactose, fat, protein and somatic cells in the milk. Also, it measured Gln and Glu in blood from these dairy cows’ calves. Results were analyzed using one-way ANOVA, T-test and Tukey’s test, with a 5% significance level. There was a difference in blood [Gln] in from dairy cows (P < 0.05), with lost concentration observed at 2nd (~0.181 μmol/mL) and 5th (~0.190 μmol/mL) months of lactation and the highest at 10th month (~0.276 μmol/mL). Also there was a higher protein content in the 5th and 10th months of lactation (~3.61% each) when compared to the other months (P < 0.05). There was no difference in calves’ parameters and in all others parameters from dairy cows. We concluded that the lactation period produced a significant interference in blood [Gln] but not in milk [Gln] which may indicate increase in utilization or decrease in production of this amino acids during lactation in these cows under tropical conditions.
Psychoanalysis as a Hermeneutics of the Subject: Freud, Ricoeur, Lacan

Résumé La connaissance herméneutique est généralement définie comme un savoir engagé, par opposition au savoir détaché que produit la méthode scientifique. La tension entre ces deux modèles dans la théorie psychanalytique de Freud est ici mise en évidence avec l'aide de Ricœur: cette théorie interprète des intentions conscientes, mais explique en même temps la vie psychique d'une façon mécaniste en termes depulsions somatiques. On montre ensuite comment le développement lacanien de la psychanalyse rend l'être habituellement caché de la subjectivité—l'inconscient—accessible comme langage. Structuré comme un langage, l'inconscient est articulé et interprétable; et son interprétation est accès au langage du «réel», par-delà les limites de l'objectivité scientifique.
Arteriosclerosis and Thrombosis Vol 11 , No 6 November / December 1991 protocol developed for the Arteriosclerosis Risk in Communities Study (

The extent of carotid artery atherosclerosis as measured by B-mode ultrasound has been shown to be strongly and independently correlated with the presence or absence of coronary atherosclerotic disease (CAD), but no studies to date have used carotid B-mode ultrasound to compare the extent of atherosclerotic disease in the two arterial circulations. We used data from a registry of patients undergoing cardiac catheterization and B-mode ultrasound of the carotid arteries to compare the extent of CAD (number of major coronary vessels with 50% or greater stenosis as judged by a consensus interpretation) with the extent of extracranial carotid atherosclerosis. Four hundred thirty-four patients (234 men, 200 women) greater than 40 years of age were stratified by gender and then divided into quartiles on the basis of a B-mode score that was derived by summing arterial wall thickness at nine sites in the left and nine sites in the right carotid arteries. Evaluation of extent of CAD for the four B-mode quartiles showed that men in the lowest B-mode quartile were over six times more likely to have normal coronary arteries than threeto four-vessel CAD, while men in the highest B-mode quartile were over 10 times more likely to have threeto four-vessel CAD than normal coronary arteries. The findings were similar for women but not as dramatic Gender-specific discriminant function models using traditional risk factors alone or in combination with B-mode score were developed to predict the extent of CAD. Discriminant models containing traditional risk factors alone performed only slightly better than a model that contained only the B-mode score. The addition of the B-mode score to models of traditional risk factors added little to the predictive ability for CAD extent (/Irteriosclerosis and Thrombosis 1991;11:1786-1794)
Prognostic Significance of the Cancer Stem Cell Markers CD133, CD44, and CD166 in Colorectal Cancer

CD133, CD44, and CD166 are cell surface markers that have recently been associated with colorectal cancer stem cells. As which of these markers has the greatest impact on patient prognosis is currently unknown, we compared their expression and prognostic significance in 110 colorectal adenocarcinomas. We demonstrate that expression of CD133 correlates with that of CD166, while both do not correlate with CD44. We show that CD133 is the best sole marker to predict low patient survival, while the combined analysis of all three markers may be superior in identification of low-, intermediate-, and high-risk cases of colorectal cancer.
Immune responses to tyrophagus putrescentiae-induced airway inflammation in mice.

BACKGROUND Storage mites are a source of aeroallergens that affect patients with allergic rhinitis and asthma. Tyrophagus putrescentiae is a causative factor of airway hypersensitivity, but the mechanisms and pathogenesis of Tputrescentiae-induced allergy are not well understood. OBJECTIVE This study aimed to develop a murine model of T putrescentiae-induced allergic asthma. METHODS Immune responses and physiologic variations in immunoglobulins (Ig), leukocyte subpopulations, cytokines, gene expression, pulmonary function, and lung pathology were evaluated after intraperitoneal sensitization and intratracheal challenge with crude extract of T putrescentiae. RESULTS After sensitization with aluminum hydroxide and challenge with T putrescentiae in mice, levels of T putrescentiae-specific IgE and IgG1 in sera increased significantly compared to the normal saline group (P < .01): Values for inflammatory leukocytes (neutrophils and eosinophils) and cytokines (interleukin [IL] 4, IL-5, and IL-13) increased significantly after sensitization. In terms of pulmonary function, pause values were significantly enhanced in T putrescentiae-sensitized mice after intratracheal challenge with T putrescentiae (P < .05). Expression of type 2 helper T cell (T(H)2)-related genes (IL4, IL5, IL13, and RANTES), T(H)2-specific transcription factor (GATA-3), and proinflammatory genes (IL6), and T(H)(H)17-related genes (IL17F) increased significantly after airway challenge. Sensitization with T putrescentiae crude extract led to inflammation of lung tissue, thickening of the tracheal wall, and tracheal rupture. CONCLUSIONS Intraperitoneal sensitization followed by intratracheal challenge with crude extract of T putrescentiae can induce airway inflammation in BALB/c mice. The symptoms observed in a mouse model of allergic asthma, in terms of immune and clinical parameters, are reminiscent of the symptoms of allergic asthma in humans. A mouse model can be used to evaluate the therapeutic effectiveness of drugs on T putrescentiae-induced airway inflammation in humans.
Distribution of Human Papillomavirus and Antisperm Antibody in Semen and Its Association with Semen Parameters Among Infertile Men

Background: Sexually transmitted infections (STIs) can be associated with infertility. Human papillomavirus (HPV) has been identified as a potential agent in male infertility. Also, anti-sperm antibodies (ASA) have been detected in men with infertility. The aim of this study was to investigate the prevalence and association of HPV and ASA in infected semen of infertile men. Methods: This cross-sectional study was performed on 96 infertile men referring to infertility treatment center of Kashan University of Medical Sciences during March 2017 till September 2017 in Iran. Semen analysis and diagnostic PCR test were performed for detection of HPV DNA. The semen parameters in HPV infected and ASA positive samples were compared with HPV non-infected and ASA negative samples. Chi square test was used to determine the correlation between variables and p<0.05 was considered statistically significant. Results: HPV DNA and ASA were detected in 17.4% and 15.2% of 96 semen samples, respectively. Semen volume, sperm count, sperm motility and the normal morphology rate were significantly decreased in HPV-positive subjects (p=0.004, p= 0.016, p<0.001, and p=0.017, respectively). Also, sperm motility was significantly decreased in ASA-positive subjects (p=0.002), also patients with HPV infection had a higher rate of ASA than the non-HPV group. In contrast to ASA, HPV infection had a significant correlation with education level (p=0.039). Conclusion: The findings suggest that asymptomatic seminal infection of HPV and ASA by adversely affecting sperm quality, in particular sperm motility and count, may play an important role in male infertility.
Relations among depression, self-efficacy and optimism in a sample of nurses in Taiwan.

AIMS The present study investigated the level of depression among hospital nurses, to examine personality contributions to depression and to offer managers relevant organizational strategies to reduce levels of depression. BACKGROUND The World Health Organization's Global Burden of Disease Study estimates that major depression is the leading cause of disability among women in the world today. It is surprising that there is a relative dearth of research investigating depression among nursing staff. METHOD A cross-sectional survey of 314 staff nurses in a general hospital in Taiwan. Participants completed a set of questionnaires and a demographic information form. A number of statistical methods were used including descriptive statistics, product-moment correlations and multiple regression analysis. RESULTS In all, 52.5% of nurses reported mild-to-moderate depressive symptoms. Self-efficacy and optimism were significant buffers against depression. CONCLUSIONS The results of the present study confirm the importance of self-efficacy and optimism. Nurses with positive evaluation and expectation towards their self and others tend to report lower depression levels. IMPLICATIONS FOR NURSING MANAGEMENT The results of the present study indicate that there is an immediate need to pay further attention to nurses' depression issues. It is therefore suggested that Nursing Managers take an empowering approach to strengthen nurses' self-efficacy and optimism levels to prevent depression in this profession.
Estimation of Dairy Particulate Matter Emission Rates by Lidar and Inverse Modeling

Particulate matter (PM) emissions from agricultural operations are an important issue for air quality and human health and a topic of interest to government regulators. PM emission rates from a dairy in the San Joaquin Valley of California were investigated during June 2008. The facility had 1,885 total animals, including 950 milking cows housed in free-stall pens with an open-lot exercise area, and 935 dry cows, steers, bulls, and heifers housed in open lots. Point sensors, including filter-based aerodynamic mass samplers and optical particle counters (OPC), were deployed at select points around the facility to measure optical and aerodynamic particulate concentrations. Simultaneously, vertical PM concentration profiles were measured both upwind and downwind of the facility using lidar. The lidar was calibrated to provide mass concentration information using the OPCs and filter measurements. Emission rates were estimated over this period using both an inverse modeling technique coupled with the filter-based measurements and a mass-balance technique applied to lidar data. Mean emission rates calculated using inverse modeling (±95% confidence interval) were 3.8 (±3.2), 24.8 (±14.5), and 75.9 (±33.2) g d-1 AU-1 for PM2.5, PM10, and TSP, respectively. Mean emissions rates based on lidar data were 1.3 (±0.2), 15.1 (±2.2), and 46.4 (±7.0) g d-1 AU-1 for PM2.5, PM10, and TSP, respectively. The PM10 findings are roughly twice as high as those reported from other dairy studies with different climatic conditions and/or housing types, but are of similar magnitude as those from a study with similar conditions, housing, and emission rate calculation technique.
Myeloid Cell–Derived HIF-1α Promotes Control of Leishmania major

Hypoxia-inducible factor-1α (HIF-1α), which accumulates in mammalian host organisms during infection, supports the defense against microbial pathogens. However, whether and to what extent HIF-1α expressed by myeloid cells contributes to the innate immune response against Leishmania major parasites is unknown. We observed that Leishmania-infected humans and L. major–infected C57BL/6 mice exhibited substantial amounts of HIF-1α in acute cutaneous lesions. In vitro, HIF-1α was required for leishmanicidal activity and high-level NO production by IFN-γ/LPS-activated macrophages. Mice deficient for HIF-1α in their myeloid cell compartment had a more severe clinical course of infection and increased parasite burden in the skin lesions compared with wild-type controls. These findings were paralleled by reduced expression of type 2 NO synthase by lesional CD11b+ cells. Together, these data illustrate that HIF-1α is required for optimal innate leishmanicidal immune responses and, thereby, contributes to the cure of cutaneous leishmaniasis.
Prevalence of periconceptional folic acid use and perceived barriers to the postgestation continuance of supplemental folic acid: survey results from a Teratogen Information Service.

BACKGROUND Fewer than 40% of U.S. women are taking folic acid supplements periconceptionally at a time when the risk of neural tube defects (NTDs) can be reduced by supplementation. A better understanding of the vitamin-taking habits of childbearing-age women and effective methods for improving periconceptional supplement use are needed. METHODS A telephone survey conducted through the California Teratogen Information Service (TIS) between August 2003 and January 2004 assessed the prevalence and characteristics of pregnant callers who did not use folic acid supplements in the periconceptional period, and explored attitudes toward advice to continue vitamin use following pregnancy in order to be protected in a future pregnancy. RESULTS A total of 327 pregnant women who called the TIS for information agreed to participate in the survey. More than half (53.2%) were not taking folic acid-containing supplements in the periconceptional period. Predictors of lack of use included a higher prepregnancy body mass index, younger maternal age, non-white race/ethnicity, lower education level, and unplanned pregnancy. One-quarter of the women said they would be willing to continue taking vitamins after the pregnancy if advised to do so by a physician. The remainder identified obstacles to following that advice--notably, not planning to become pregnant again and the belief that enough folate is derived from diet alone. CONCLUSIONS More than half of the callers to the TIS were not compliant with recommendations regarding periconceptional folic acid supplementation. This represents an opportunity for TIS specialists and physicians to intervene in a current pregnancy to encourage maintenance of supplement use in the subsequent interpregnancy interval.
Sustaining Strategic Advantage in the Information Age 1 ossci 01

In the Information Age, the dynamics of competition is intensifying. In such dynamic environments, how long can firms exploit an (IT-based) advantage? We classify various well-known IT strategy frameworks by the strategy theory they are based on and summarize their basic logic. We show that traditional strategy thinking ignores speed of change or dynamics of competition. A new strategy framework, Sustainability Analysis [69,70], extends strategy theory, takes into account dynamics and different speeds of change. We describe this new strategy framework and how it advances our understanding regarding the sustainability of a competitive (IT-based) advantage.
The Role of Ion Exchange Membranes in Membrane Capacitive Deionisation

Ion-exchange membranes (IEMs) are unique in combining the electrochemical properties of ion exchange resins and the permeability of a membrane. They are being used widely to treat industrial effluents, and in seawater and brackish water desalination. Membrane Capacitive Deionisation (MCDI) is an emerging, energy efficient technology for brackish water desalination in which these ion-exchange membranes act as selective gates allowing the transport of counter-ions toward carbon electrodes. This article provides a summary of recent developments in the preparation, characterization, and performance of ion exchange membranes in the MCDI field. In some parts of this review, the most relevant literature in the area of electrodialysis (ED) is also discussed to better elucidate the role of the ion exchange membranes. We conclude that more work is required to better define the desalination performance of the proposed novel materials and cell designs for MCDI in treating a wide range of feed waters. The extent of fouling, the development of cleaning strategies, and further techno-economic studies, will add value to this emerging technique.
Gestión tecnológica hospitalaria : Un enfoque sistémico

Este texto contribuira a que la institucion de salud se organice y prepare la informacion necesaria para emprender el largo y tortuoso camino de la determinacion de la razon costo/beneficio y de la acreditacion. Ademas, podra ser muy util para los estudiantes de los programas de pregrado y posgrado de ingenieria biomedica que se quieran especializar en la gestion de tecnologias del equipamiento biomedico y la ingenieria clinica. Tambien podra ser usado como guia de referencia por personas que esten directamente vinculadas al sector de la salud en departamentos de mantenimiento, ingenieria clinica o de servicios hospitalarios.
Treponemal Antigens as Related to Identification and Syphilis Serology

Summary 1. The antigens of intact T.p., the R.t. , T.m. and the free-living mud organism, T.z. , are compared. 2. An antigen appearing to be identical to the Reiter Protein antigen was found to be a common or shared component in all of the treponemes studied. 3. By means of absorption or blocking procedures and employing FA methods, all treponemes could be identified. 4. It is suggested that FA methods can play an important part in future taxonomic studies of treponemes and that the FTA test can be modified so as to increase both sensitivity and specificity.
Infant-Directed Visual Prosody: Mothers' Head Movements and Speech Acoustics.

Acoustical changes in the prosody of mothers' speech to infants are distinct and near universal. However, less is known about the visible properties mothers' infant-directed (ID) speech, and their relation to speech acoustics. Mothers' head movements were tracked as they interacted with their infants using ID speech, and compared to movements accompanying their adult-directed (AD) speech. Movement measures along three dimensions of head translation, and three axes of head rotation were calculated. Overall, more head movement was found for ID than AD speech, suggesting that mothers exaggerate their visual prosody in a manner analogous to the acoustical exaggerations in their speech. Regression analyses examined the relation between changing head position and changing acoustical pitch (F0 ) over time. Head movements and voice pitch were more strongly related in ID speech than in AD speech. When these relations were examined across time windows of different durations, stronger relations were observed for shorter time windows (< 5 sec). However, the particular form of these more local relations did not extend or generalize to longer time windows. This suggests that the multimodal correspondences in speech prosody are variable in form, and occur within limited time spans.
Protein restriction: a revisited old strategy with new opportunities?

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The use of self‐learning modules to facilitate learning of basic science concepts in an integrated medical curriculum

This study used qualitative and quantitative approaches to evaluate the effectiveness of self‐learning modules (SLMs) developed to facilitate and individualize students' learning of basic medical sciences. Twenty physiology and nineteen microanatomy SLMs were designed with interactive images, animations, narrations, and self‐assessments. Of 41 medical students, 40 students voluntarily completed a questionnaire with open‐ended and closed‐ended items to evaluate students' attitudes and perspectives on the learning value of SLMs. Closed‐ended items were assessed on a five‐point Likert scale (5 = high score) and the data were expressed as mean ± standard deviation. Open‐ended questions further evaluated students' perspectives on the effectiveness of SLMs; student responses to open‐ended questions were analyzed to identify shared patterns or themes in their experience using SLMs. The results of the midterm examination were also analyzed to compare student performance on items related to SLMs and traditional sessions. Students positively evaluated their experience using the SLMs with an overall mean score of 4.25 (SD ± 0.84). Most students (97%) indicated that the SLMs improved understanding and facilitated learning basic science concepts. SLMs were reported to allow learner control, to help in preparation for subsequent in‐class discussion, and to improve understanding and retention. A significant difference in students' performance was observed when comparing SLM‐related items with non‐SLM items in the midterm examination (P < 0.05). In conclusion, the use of SLMs in an integrated basic science curriculum has the potential to individualize the teaching and improve the learning of basic sciences. Anat Sci Educ 3: 219–226, 2010. © 2010 American Association of Anatomists.