Miracle-dz/UniFAR-FTUs huggingface dataset:
DETERMINANTS OF BRAND EQUITY: AN EMPIRICAL STUDY OF IT INDUSTRY

The performance of any brand can be measured by many methods. One of the widely used ways to calculate brand performance is through brand equity. Brand equity can be observed by customer’s perspective as well as financial perspective. This research paper investigates the impact of advertising & promotion, research & development (R&D) and profitability (return on assets) on brand equity. In this research paper data is used from 20 international IT brands for a period of 5 years from 2011 to 2015. The results show that advertising & promotion and profitability have statistically significant impact on brand equity whereas R&D doesn’t make significant impact on brand equity. Based on the findings, it is observed that advertising is having the strongest impact on brand equity.
Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia

Temozolomide sensitivity is determined by methylation of the O6‐methylguanine‐DNA methyltransferase (MGMT) promoter. This study assessed whether the temozolomide dose can be tailored by MGMT promoter status and whether protracted, low‐dose temozolomide can “prime” blasts in patients with unmethylated MGMT (unMGMT). Elderly patients with high‐risk AML were stratified by MGMT methylation. Patients with methylated MGMT (mMGMT) received temozolomide 200 mg/m2 orally for 7 days every 4 weeks, while patients with unMGMT received temozolomide 100 mg/m2 orally for 14 days followed by 200 mg/m2 orally for 7 days every 6weeks. Of 36 patients (median age, 75 years), 31 (86%) had an unMGMT promoter. Overall response rate for the entire cohort was 36%. Patients with mMGMT and unMGMT had similar response rates (40% vs. 29%). Median duration of response and overall survival (OS) among responders were 29 and 35 weeks, respectively. Induction deaths (ID) occurred in 25% of patients, mostly caused by disease progression. Hematological toxicities were the most common adverse event. Toxicities were similar between patients on conventional versus protracted schedules. High HCT‐CI scores were predictive of lower CR rate, higher ID, and shorter OS, while bone marrow blast count <50% at screening predicted for improved responses. Temozolomide, dosed according to MGMT methylation status, demonstrated modest clinical activity in elderly patients with AML, especially in those presenting with fewer comorbidities and low disease burden. The trial was registered on www.ClinicalTrials. gov as #NCT00611247. Am. J. Hematol. , 2012. © 2011 Wiley Periodicals, Inc.
Requirement of neuronal‐ and cardiac‐type sodium channels for murine sinoatrial node pacemaking

The majority of Na+ channels in the heart are composed of the tetrodotoxin (TTX)‐resistant (KD, 2–6 μm) Nav1.5 isoform; however, recently it has been shown that TTX‐sensitive (KD, 1–10 nm) neuronal Na+ channel isoforms (Nav1.1, Nav1.3 and Nav1.6) are also present and functionally important in the myocytes of the ventricles and the sinoatrial (SA) node. In the present study, in mouse SA node pacemaker cells, we investigated Na+ currents under physiological conditions and the expression of cardiac and neuronal Na+ channel isoforms. We identified two distinct Na+ current components, TTX resistant and TTX sensitive. At 37°C, TTX‐resistant iNa and TTX‐sensitive iNa started to activate at ∼−70 and ∼−60 mV, and peaked at −30 and −10 mV, with a current density of 22 ± 3 and 18 ± 1 pA pF−1, respectively. TTX‐sensitive iNa inactivated at more positive potentials as compared to TTX‐resistant iNa. Using action potential clamp, TTX‐sensitive iNa was observed to activate late during the pacemaker potential. Using immunocytochemistry and confocal microscopy, different distributions of the TTX‐resistant cardiac isoform, Nav1.5, and the TTX‐sensitive neuronal isoform, Nav1.1, were observed: Nav1.5 was absent from the centre of the SA node, but present in the periphery of the SA node, whereas Nav1.1 was present throughout the SA node. Nanomolar concentrations (10 or 100 nm) of TTX, which block TTX‐sensitive iNa, slowed pacemaking in both intact SA node preparations and isolated SA node cells without a significant effect on SA node conduction. In contrast, micromolar concentrations (1–30 μm) of TTX, which block TTX‐resistant iNa as well as TTX‐sensitive iNa, slowed both pacemaking and SA node conduction. It is concluded that two Na+ channel isoforms are important for the functioning of the SA node: neuronal (putative Nav1.1) and cardiac Nav1.5 isoforms are involved in pacemaking, although the cardiac Nav1.5 isoform alone is involved in the propagation of the action potential from the SA node to the surrounding atrial muscle.
Management of Primary Cutaneous Melanoma of the Hands and Feet: A Clinicoprognostic Study

BACKGROUND Although acral lentiginous melanoma is the most common subtype of malignant melanoma in acral locations, the term acral melanoma (AM) has to be differentiated from the histopathologic description. OBJECTIVES To characterize the clinical and pathologic features of patients with a primary AM and to elucidate whether the prognosis of patients with AM differs from that of those with melanoma at other sites (nonacral melanoma; NAM). PATIENTS AND METHOD Over a 20‐year period, a series of 822 consecutive patients with melanoma were recorded in the database. Clinical and follow‐up data were retrieved from the melanoma register and prospectively analyzed. RESULTS Eighty‐nine patients had a malignant melanoma located on the acral sites of extremities. Breslow thickness and Clark level were found to be related to specific and disease‐free survival. Breslow thickness greater than 4 mm was associated with greater risk of recurrence, and amelanosis and age of 60 and older were significantly associated with greater risk of death. Comparison of survival of patients with AM with that of those with NAM clearly showed that disease‐free survival and overall survival were significantly lower in the former. CONCLUSION Survival differences between patients with AM and NAM are due to differences in already known prognostic factors, probably as a consequence of a delay in the diagnosis in these locations.
New Flying-Capacitor-Based Multilevel Converter With Optimized Number of Switches and Capacitors for Renewable Energy Integration

The flying-capacitor-based multilevel converter is one of the well-known breeds of the multilevel power converters. This paper proposes a new flying-capacitor-based multilevel converter to minimize the number of flying capacitors (FCs) and power switches. The advantage of the proposed FC-based multilevel converter in comparison with the conventional flying-capacitor multicell converter is that it needs fewer FCs. Also, in comparison with the stacked multicell converter, the proposed multilevel converter requires fewer semiconductor switches. In order to balance the voltage of the FCs in proposed multilevel converter, a new active voltage balancing method which is fully implemented using logic-form equations is presented. The proposed voltage balancing method measures output current and FC voltages to generate switching states to produce the required output voltage level, as well as balance the FCs voltages at their reference values. The output voltage of the proposed multilevel converter controlled with suggested active voltage balancing method can be modulated with any pulse-width-modulation (PWM) method, such as phase-shifted-carrier PWM or level-shifted-carrier PWM. Simulation results and experimental measurements of proposed FC-based multilevel converter are presented to verify the performance of the proposed converter, and its novel switching and modulation strategy, which is based on the active voltage balancing method.
Behaviour, attention and cognition in severe dyslexia

Information about coexisting problems in dyslexia may be vital for diagnostic and remedial procedures. There are few studies in this area, and to our knowledge none for the students in focus in this study. They all have phonological deficits and severely impaired reading abilities, in spite of prolonged educational remediation. The aim was to assess if these students have more behavioural/emotional problems than normal reading students. A clinical sample of 70 students, 59 males and 11 females, were compared to a normal reading control group. The groups were pair-wise matched on age, gender, cognitive level, and whether they lived in rural or urban areas. Mean age for the two groups was 150 months, and mean IQ scores approximately 100. Information on behaviour/emotions was obtained from parents, teachers and participants by means of the Child Behavior Checklist, Teacher's Report Form and Youth Self Report. The dyslexia group showed significantly more problems in all areas than the controls. This was reported from all three groups of informants. Parents reported most problems, internalizing behaviour for more than 50% of the participants and total problem behaviour for nearly 45%. Significantly more attention problems were also reported for the dyslexia group from all informants. Parents reported that nearly half the group demonstrated attention problems. Both groups of participants had more problems reported for those with IQ scores of 100 or lower. Further research is needed in this area, but the results clearly indicate that identifying additional behavioural/emotional problems may be imperative for students with severe reading problems.
The influence of team members on nurses’ perceptions of transgressive behaviour in care relationships: A qualitative study

AIM The aim of this study was to gain insight into the influence of team members in how nurses perceive and address patients' transgressive behaviour. BACKGROUND Aggression and transgressive behaviour in health care have been a focus of research over the past few decades. Most studies have focused on individual nurses' experiences with aggression and transgressive behaviour. Literature examining group dynamics in nursing teams and team members' interactions in handling patients' transgressive behaviour is scarce. DESIGN Qualitative interview study. METHODS Seven focus-group interviews and two individual interviews were carried out in 2014-2016. Twenty-four nurses were drawn from eight wards in three general hospitals. Interviews were analysed using the constant comparative method influenced by the grounded theory approach. FINDINGS While elaborating how they perceived and addressed transgressive behaviour, nurses disclosed how interactions with team members occurred. Several patterns arose. Nurses talk to one another, excuse one another, fill in for one another, warn one another and protect and safeguard one another. In these patterns in reaction to patients' transgressive behaviour, implicit group norms transpire, causing nursing teams to acquire their specific identity "as a group". Consequently, these informal group norms in nursing teams impinge how nurses feel threatened by patients' potential transgressive behaviour; gain protection from the group of nurses and conform to informal ward rules. CONCLUSION The findings of this study can support intervention strategies aimed at supporting nurses and nursing teams in managing patient aggression and transgressive behaviour by identifying and explicating these group dynamics and team members' interactions.
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation

The abundance of the cyclin-dependent kinase (CDK) inhibitor p57Kip2, an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway. The Skp1/Cul1/F-box (SCF)-type E3 ubiquitin ligase complex SCFSkp2 has now been shown to be responsible for regulating the cellular level of p57Kip2 by targeting it for ubiquitylation and proteolysis. The elimination of p57Kip2 was impaired in Skp2-/- cells, resulting in abnormal accumulation of the protein. Coimmunoprecipitation analysis also revealed that Skp2 interacts with p57Kip2 in vivo. Overexpression of WT Skp2 promoted degradation of p57Kip2, whereas expression of a dominant negative mutant of Skp2 prolonged the half-life of p57Kip2. Mutation of the threonine residue (Thr-310) of human p57Kip2 that is conserved between the COOH-terminal QT domains of p57Kip2 and p27Kip1 prevented the effect of Skp2 on the stability of p57Kip2, suggesting that phosphorylation at this site is required for SCFSkp2-mediated ubiquitylation. Finally, the purified recombinant SCFSkp2 complex mediated p57Kip2 ubiquitylation in vitro in a manner dependent on the presence of the cyclin E-CDK2 complex. These observations thus demonstrate that the SCFSkp2 complex plays an important role in cell-cycle progression by determining the abundance of p57Kip2 and that of the related CDK inhibitor p27Kip1.
Working the space: locating teachers’ voices in large-scale, mandated curriculum reform

The educational landscape is one of significant change. This thesis is concerned with the early responses of a group of teachers to large-scale, mandated curriculum reform at one independent P-12 school located in regional Queensland. The literature on curriculum reform and teacher agency suggests that teachers respond in wide-ranging ways to curriculum change. There is, however, a gap in the literature with regard to how teachers’ perceptions of their own capacities, which contribute to the formation of their dispositions, inform their engagement practices and, consequently, their responses to large-scale, mandated change. This study explored these relationships by focusing on the engagement, mediation and negotiation practices of six teachers as they made early preparations to implement Phase One of the Australian Curriculum, in 2012. This study sought to examine these practices in two ways. First, it drew on aspects of Bourdieu’s (1990; 1991; 1993) field theory and utilised the concept of habitus to describe the policy field of prescribed curriculum and the enacted field of teachers’ work in the classrooms where they practise. Second, in focusing on this space between policy as text and policy as practice, this study examined how teachers’ dispositions influenced their perceptions of their capacity to engage with curriculum policy and undertake its implementation. The conceptual lens for the research focus used to analyse the operations of the space was shaped by Albert Bandura’s (1995; 2001; 2008) theory of cognition; particularly his concept of self-efficacy. Bandura’s work casts light on the way in which individual responses can move beyond the reactive to become agentive. By focusing attention on the way these teachers engaged with, mediated and contextualised curriculum change, the study aimed to provide insights into the complex nature of teachers’ work within their operational space, as they negotiated and interpreted the requirements of this large-scale, mandated reform. The findings of this research indicated that whilst an individual’s self-efficacy perceptions significantly influenced their professional actions and interactions, an understanding by leaders and managers of an individual’s self-efficacy dispositions could mediate negative and resistant behaviours towards change. These findings have resonance for discussions around the effective leadership and management of organisational change, particularly for those working in the areas of policy reform, most specifically large-scale, mandated education reform since it promotes achieving reform efficacy from the teachers’ perspective. Such an approach privileges teacher agency in education policy decision-making and implementation.
Karyotypes of Six Soricomorph Species from Emei Shan, Sichuan Province, China

We report the karyotypes of six species of the order Soricomorpha (Mammalia), based on specimens collected from Emei Shan (Mount Emei) in central Sichuan Province, China: two talpid species, Uropsilus andersoni (diploid chromosome number [2n]=34, fundamental number of chromosome arms including two X chromosomes [FN]=56) and Scaptonyx fusicaudus (2n=34, FN=64); and four soricid species, Episoriculus sacratus (2n=58, FN=108), Anourosorex squamipes (2n=48, FN=96), Sorex cylindricauda (2n=30, FN=50), and Sorex bedfordiae (2n=24/25, FN=46/48). This is the first report of the karyotypes of all species except Sc. fusicaudus and A. squamipes. Episoriculus sacratus is considered to be a valid species in Sichuan, separated from the Nepalese E. soluensis based on differences in the karyotype. The karyotype of S. bedfordiae showed polymorphism due to the occurrence of a B chromosome. Differences in the karyotypes of S. cylindricauda and S. bedfordiae could be explained mostly by seven Robertsonian translocations revealed by G-band karyotypes.
The ‘CEO’ Effect on the Performance of Brazilian Companies: An Empirical Study Using Measurable Characteristics

The experience and competence of CEOs may have a positive influence on the performance of firms. Using secondary data on the performance of 73 Brazilian listed companies and primary data collected through a survey of the social and demographic characteristics of CEOs we tested a set of hypotheses concerning the influence of CEOs on the performance of the firms they headed between 1997 and 2012. Specifically, we examined the relationships between CEOs’ experience and competence regarding common accounting indicators. The results indicate that CEOs with diverse experience would not do better in dynamic environments, and that specific experience has a negative effect on performance. Furthermore, CEOs with formal education do not show better short-term performance, and tenure has an inverted U-shaped relationship with the firm's performance. This article helps to provide a better understanding of the behavior of Brazilian CEOs by examining their characteristics.
Phylogenetic Affinities of Auriculostoma (Digenea: Allocreadiidae), with Descriptions of Two New Species From Peru

abstract: Two new allocreadiid trematodes are described from the intestine of characid fishes from Rio Itaya, a tributary of the Amazon River near Iquitos, Peru. Auriculostoma foliaceum n. sp. is described from Bryconops cf. caudomaculatus (Günther, 1864) Backup, 2003, and Auriculostoma diagonale n. sp. from Stethaprion cf. erythrops Cope, 1870. Auriculostoma foliaceum n. sp. differs from its congeners by having a foliated lateral margin and lacking vitelline follicles in the forebody. Auriculostoma diagonale n. sp. differs from all of its congeners except Auriculostoma platense (Szidat, 1954) Scholz, Aguirre-Macedo, and Choudhury, 2004, by having oblique rather than tandem testes and differs from A. platense by having a much more elongated cirrus sac. Phylogenetic hypotheses based on analyses of 3 alignments of partial sequences of the 28S rDNA gene conducted in this study provide a framework for revaluating the classification of Allocreadiidae Looss, 1902. The present analyses show that (1) Paracreptotrematina limi Amin and Myer, 1982, does not belong in the Allocreadiidae; (2) Creptotrematina aguirrepequenoi Jiménez-Guzmán, 1973 (spelled here without diacritic mark), does not belong to Paracreptotrematina Amin and Myer, 1982, but remains in the Allocreadiidae; (3) Auriculostoma astyanace Scholz, Aguirre-Macedo, and Choudhury, 2004, is closely related to C. aguirrepequenoi and Wallinia chavarriae Choudhury, Hartvigsen-Daverdin, and Brooks, 2002; (4) Megalogonia Surber, 1928, is retained as an accepted genus in the Allocreadiidae; and (5) Margotrema Lamothe-Argumedo, 1970, is found to be nested among 3 species of Crepidostomum Braun, 1900.
Defining public-sector entrepreneurship

Public-sector entrepreneurship (PSE) is a relatively new area of enquiry. Though it is now universally agreed that the public sector can be entrepreneurial just like its private sector counterpart, it is not clear what makes up the PSE construct. The study proposes three dimensions of what makes up PSE. The three are, economic facilitation and regulation, the civil–political service agent and commercial market participation. The dimensions are based on the different roles the state plays in trying to optimally provide public value to its citizens. This study offers a conceptual definition that could more broadly represent PSE. As with any new concept, this conceptual framework still has to be tested for efficacy and be validated through future research.
RelA Is a Component of the Nutritional Stress Activation Pathway of the Bacillus subtilis Transcription Factor σB

ABSTRACT The general stress regulon of Bacillus subtilis is induced by the activation of the σB transcription factor. Activation of σB occurs when one of two phosphatases (RsbU and RsbP), each responding to a unique type of stress, actuates a positive regulator of σB by dephosphorylation. Nutritional stress triggers the RsbP phosphatase. The mechanism by which RsbP becomes active is unknown; however, its activation coincides with culture conditions that are likely to reduce the cell's levels of high-energy nucleotides. We now present evidence that RelA, a (p)ppGpp synthetase and the key enzyme of the stringent response, plays a role in nutritional stress activation of σB. An insertion mutation that disrupts relA blocks the activation of σB in response to PO4 or glucose limitation and inhibits the drop in ATP/GTP levels that normally accompanies σB induction under these conditions. In contrast, the activation of σB by physical stress (e.g., ethanol treatment) is not affected by the loss of RelA. RelA's role in σB activation appears to be distinct from its participation in the stringent response. Amino acid analogs which induce the stringent response and RelA-dependent (p)ppGpp synthesis do not trigger σB activity. In addition, neither a missense mutation in relA (relA240GE) nor a null mutation in rplK (rplK54), either of which is sufficient to inhibit the stringent response and RelA-dependent (p)ppGpp synthesis, fails to block σB activation by PO4 or glucose limitation.
BaS Analysis: Suggesting a New Cephalometric Model in Follow-up of Patients With Craniostenosis Who Underwent Craniofacial Advancement Surgery After 1 Year From the End of the Distraction Protocol

Evaluation of the relapse in patients with craniofacial malformation who underwent craniofacial advancement surgery is very difficult, and data are often unreliable. This is because common skeletal landmarks move from their original position, making standard cephalometries completely useless. To solve this problem, some authors proposed evaluations based on 2- and 3-dimensional computed tomographies, but the biologic risk and the economic outcome do not consent to repeat this kind of examination too often. In this paper, the authors propose a new cephalometric model based on the evaluation of facial skeletal landmarks on the BaS axis. This method, named BaS analysis, might be useful in evaluating improvements of the splanchnocranium in patients who underwent craniofacial advancement.
The impact of innovation training on successful outcomes in public–private partnerships

ABSTRACT Public–private partnerships (PPPs) are increasingly seen as a way of innovating the production and management of public services. However, the question of what drives innovation in partnerships has so far received only limited attention. Drawing on network governance and collaborative innovation literature, this article presents the findings from a survey among 260 Danish PPPs. The study shows that while innovation training has a significant effect on achieving innovation in PPPs, factors such as trust and institutional support only affect some innovation types. The findings demonstrate the importance of individual innovation skills and a differentiated understanding of innovation outcomes in PPPs.