Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of pyrotinib exposure based on physiologically-based pharmacokinetic model and endogenous biomarker

Pyrotinib, a novel irreversible epidermal growth factor receptor dual tyrosine kinase inhibitor, is mainly (about 90%) eliminated through cytochrome P450 (CYP) 3A mediated metabolism in vivo. Meanwhile, genotype is a key factor affecting pyrotinib clearance and 4β-hydroxycholesterol is an endogenous biomarker of CYP3A activity that can indirectly reflect the possible pyrotinib exposure. Thus, it is necessary to evaluate the clinical drug-drug interactions (DDI) between CYP3A perpetrators and pyrotinib, understand potential exposure in specific populations including liver impairment and geriatric populations, and explore the possible relationships among pyrotinib exposure, genotypes and endogenous biomarker. Physiologically-based pharmacokinetic (PBPK) model can be used to replace prospective DDI studies and evaluate external and internal factors that may influence system exposure. Herein, a basic PBPK model was firstly developed to evaluate the potential risk of pyrotinib coadministration with strong inhibitor and guide the clinical trial design. Subsequently, the mechanistic PBPK model was established and used to quantitatively estimate the potential DDI risk for other CYP3A modulators, understand the potential exposure of specific populations, including liver impairment and geriatric populations. Meanwhile, the possible relationships among pyrotinib exposure, genotypes and endogenous biomarker were explored. With the help of PBPK model, the DDI clinical trial of pyrotinib coadministration with strong inhibitor has been successfully completed, some DDI clinical trials may be waived based on the predicted results and clinical trials in specific populations can be reasonably designed. Moreover, the mutant genotypes of CYP3A4*18A and CYP3A5*3 were likely to have a limited influence on pyrotinib clearance, and the genotype-independent linear correlation coefficient between endogenous biomarker and system exposure was larger than 0.6. Therefore, based on the reliable predicted results and the linear correlations between pyrotinib exposure and endogenous biomarker, dosage adjustment of pyrotinib can be designed for clinical practice.
A True Paraurethral Leiomyoma, A Case Report and Review of Literature

Leiomyoma is a benign mass of smooth muscle cells that most frequently occurs in the gastrointestinal and genitourinary system. However, leiomyomas arising from the female urethra, especially paraurethral, are exceedingly rare. We present a case of a true paraurethral leiomyoma. The initial presenting complaints were dyspareunia, increased urinary frequency, and a 1.8 cm lesion in the anterolateral wall of the vagina that was suspicions of a Gartner’s duct cyst. However, the patient was lost to followup for 5 years. On return, the patient continued to complain of dyspareunia, urinary frequency, suprapubic pain, and dysuria. The patient was treated for multiple instances of urinary tract infections (UTIs) without symptomatic improvement. A pelvic MRI demonstrated a 3.8 x 4.1 x 4.7 cm mass within the left anterior aspect of the lower cervix/vagina. Cystoscopy was notable for an unremarkable urethra with an anterior vaginal wall mass extrinsically pushing the bladder trigone without penetration into the bladder mucosa or communication with the ureter or vagina. A biopsy from the paraurethral mass revealed well-delineated cells with low mitotic figures encompassed in a fibrous capsule non-adherent to adjacent structures. The mass was subsequently excised through the anterior vaginal wall with no complications and complete resolution of symptoms.
Evaluation of Antimicrobial Photodynamic Therapy Using Indocyanine Green and Near-Infrared Diode Laser Against Enterococcus faecalis in Infected Human Root Canals.

OBJECTIVE Photodynamic therapy (PDT) is considered a promising adjunct to the currently available endodontic disinfection techniques leading to more effective reduction of intracanal bacteria. The present ex vivo study aimed to assess the antimicrobial effect of PDT using indocyanine green (ICG) as photosensitizer and a near-infrared (NIR) diode laser in root canals of human teeth infected with Enterococcus faecalis. MATERIALS AND METHODS Ninety single-rooted teeth after chemomechanical preparation and sterilization were contaminated with an E. faecalis strain. The specimens were divided, randomly, into eight experimental groups: (1) PDT with ICG and laser (0.5 W output power-medium-energy fluence), (2) PDT with ICG and laser (1 W output power-high-energy fluence), (3) only laser emission, (4) only ICG, (5) 2.5% sodium hypochlorite (NaOCl) as irrigant, (6) 2.5% NaOCl and PDT with ICG and laser, (7) no treatment (positive control), and (8) no bacterial biofilm growth (negative control). The root canal contents were sampled by flushing and the collected washings were plated on an appropriate culture medium, which was incubated for 48 h at 35°C ± 2.0. The colony-forming units (CFUs) were determined to assess the bactericidal effect of the tested experimental combinations. RESULTS The microbiological tests revealed that PDT groups, regardless of the overall power, showed significant lower mean log10 CFU levels, than groups 3 and 4 (p < 0.001) and similar reduction of viable counts with group 5. The combination treatment (group 6) achieved adequate reduction of log10 CFU levels in the viable counts. However, no significant difference (p > 0.05) was observed between groups 1, 2, 5, and 6 and significant difference was noticed between groups 3, 4, and 5 (p < 0.001). CONCLUSIONS ICG-mediated PDT activated by an NIR diode laser provided increased disinfection of the root canal system, but the overall benefit in total bacterial elimination should be further investigated.
Successful Management of Neonatal Tracheoesophageal Fistula with Epidural and General Anaesthesia

Surgical repair of trachea-esophageal fistula (TEF) is one of the major neonatal emergencies that poses many challenges to the treating neonatologist, intensivist, paediatric anaesthesiologist and the surgeon. Mostly these babies are premature having physiological immaturity of various organ systems and in association they may be having lung pathologies or other major congenital defects like VATER/VACTERL anomalies. Smooth induction /maintenance, adequate intra/post operative analgesia and uneventful post-operative recovery are the major objectives to be achieved with the anaesthetic plan. The use of regional anaesthesia (RA) has found to be very safe and effective when combined with general anaesthesia (GA). We report a case of one day old baby for surgical repair of TEF (type IIIB) that was managed successfully with GA along with caudal epidural analgesia. The baby was induced and intubated under O2 +sevoflurane anesthesia and maintained with muscle relaxant atracurium. Epidural catheter was passed upto T4 through caudal route to facilitate intra and post operative analgesia with ropivacaine. There was excellent hemodynamic stability, satisfactory perioperative pain relief and uneventful recovery.
A 2-GHz wide-band direct conversion receiver for WCDMA applications

A 2-GHz direct conversion receiver for third-generation mobile communications using wide-band code division multiple access achieves -114-dBm sensitivity for 128-kb/s data at 4.096-Mcps spreading rate. The receiver is distributed on four dies. The active RC channel selection filter can be programmed to three different bandwidths from 5 to 20-MHz radio-frequency (RF) spacing; and the gain control is merged with filtering. RF and baseband chips use a 25-GHz, 0.3-/spl mu/m BiCMOS technology while the two analog-to-digital converters are implemented with a 0.5-/spl mu/m CMOS. The double-sideband noise figure is 5.1 dB at the 94-dB maximum voltage gain, and the IIP3 and ITP2 are -9.5 and +38 dBm, respectively, The receiver draws 128 mA from a 2.7-V supply.
[Diagnostic concordance between seven definitions of metabolic syndrome in overweight and obese adults].

Objectives The aim of this study was to determine the level of diagnostic concordance between seven definitions of metabolic syndrome (MS) in a group of overweight and obese adults. Materials and Methods 350 subjects aged from 19 to 70 years were recruited for study from a clinic for overweight and obese subjects. The definitions of MS used were those given by the WHO (World Health Organization), EGIR (European Group for the Study of Insulin Resistance), NCEP- ATPIII (Adult Treatment Panel), AHA/NHLBI (American Heart Association), IDF (International Diabetes Federation), and JIS (Joint Interim Statement) as well as the Szabo criteria. Concordance between the definitions was calculated with the Kappa coefficient. Insulin resistance (IR) was assessed using the HOMA-IR index. Results According to the Szabo, WHO, EGIR, NCEP-ATPIII, AHA/NHLBI, IDF, and JIS criteria, MS frequency was 74.3%, 42.0%, 46.8%, 56.0%, 52.9%, 58.6%, and 58.6%, respectively. The concordance between the Szabo and AHA/NHLBI criteria was 0.559, while the Kappa coefficient between the Szabo criteria and the rest of the guides (NCEP-ATPIII, IDF, and JIS) was from 0.612 to 0.657, respectively. The concordance of the WHO with the EGIR was 0.602, but it was between 0.358 and 0.422 with the other guidelines. IR was distributed similarly in all guidelines. Conclusions There is a considerable concordance between the NCEP-ATPIII, IDF, and JIS guidelines and the Szabo criteria. The Szabo criteria could be an option for the active surveillance of MS in populations.
Introduction of the Community Rehabilitation Northern Queensland Service

Objective: To analyse trends in length of hospital stay before and after the implementation of the Community Rehabilitation Northern Queensland Service (CRNQ) in Townsville, Australia. Design: Retrospective analysis of collected administrative data provided by the data custodian Townsville Hospital Health Service District. Setting: All patients discharged from the Townsville hospital between 1 July 2008 and 30 June 2013 for whom the Australian Refined Diagnosis Related Groups were stroke (B70), degenerative nervous system disorders (B67) or rehabilitation (Z60). Main outcome measures: Average length of stay and total number of inpatient episodes coded stroke, degenerative nervous system disorders or rehabilitation. Results: Length of stay for the selected diagnosis related groups was consistently ranging from 23 days to 25 days for the period 2008-2012. In the first year of full operational capacity of CRNQ (2012-13), there was an average reduction of six days in length of stay. The major reductions in length of stay occurred inpatients admitted for rehabilitation care. Conclusions: This study adds additional evidence that earlier discharge can be facilitated for patients with neurological conditions living outside metropolitan areas when appropriate rehabilitation services are available in the community.
PHYSICAL ACTIVITY AND BODY FAT IN ADOLESCENTS LIVING WITH HIV: A COMPARATIVE STUDY

ABSTRACT Objective: To compare regular physical activity among adolescents living with human immunodeficiency virus (HIV) with their healthy peers, and to evaluate the relationship with anthropometric indicators of body fat. Methods: This was a cross-sectional study which investigated two groups: 57 adolescents (10-15 years of age) living with HIV, and 54 apparently healthy adolescents matched for sex and age. Physical activity was evaluated using a questionnaire and anthropometric measurements were performed. The groups were compared in terms of physical activity, and the linear and partial correlations (adjusted for age and sex) between physical activity and the anthropometric indicators were tested. Results: Adolescents living with HIV had a lower total activity score than their healthy peers (1.73 versus 2.14; p<0.001), but participated more frequently in physical education activities. Soccer and walking were the physical activities most frequently reported by adolescents of the two groups. No correlation was observed between total physical activity score and anthropometric indicators of body fat when adjusted for sex and age. Female gender (β=21.51), months of exposure to antiretroviral therapy (β=1.26), and socioeconomic classes B and C (β=22.05 and 28.15, respectively) explained 33% of the sum of skinfolds in adolescents living with HIV (F=6.70; p<0.001). Conclusions: Adolescents living with HIV have lower physical activity scores compared with their healthy peers, but physical education was found to be an opportunity to increase physical activity.
Assessing the nutrition related knowledge, attitudes, and beliefs of fitness professionals

Proper nutrition is crucial when it comes to weight loss, athletic performance, and any physical activity. Three major organizations, such as American Dietetic Association, Dietitians of Canada, and the American College of Sports Medicine announced, “Physical activity, athletic performance, and recovery from exercise are enhanced by optimal nutrition” (2009). A combination of physical activity and nutrition treatment gives a better health outcome than just physical activity alone. A keystone in physical activity, especially when it comes to vigorous physical activity, is through modification of diet.1 Previous research has shown that to maintain steady body weight, while increasing physical activity levels, energy requirement is necessary for maintaining good health.2
In vitro biotransformation assays using fish liver cells: Comparing rainbow trout and carp hepatocytes

Biotransformation assays using primary hepatocytes from rainbow trout, Oncorhynchus mykiss, were validated as a reliable in vitro tool to predict in vivo bioconcentration factors (BCF) of chemicals in fish. Given the pronounced interspecies differences of chemical biotransformation, the present study aimed to compare biotransformation rate values and BCF predictions obtained with hepatocytes from the cold-water species, rainbow trout, to data obtained with hepatocytes of the warm-water species, common carp (Cyprinus carpio). In a first step, we adapted the protocol for the trout hepatocyte assay, including the cryopreservation method, to carp hepatocytes. The successful adaptation serves as proof of principle that the in vitro hepatocyte biotransformation assays can be technically transferred across fish species. In a second step, we compared the in vitro intrinsic clearance rates (CLin vitro, int) of two model xenobiotics, benzo[a]pyrene (BaP) and methoxychlor (MXC), in trout and carp hepatocytes. The in vitro data were used to predict in vivo biotransformation rate constants (kB) and BCFs, which were then compared to measured in vivo kB and BCF values. The CLin vitro, int values of BaP and MXC did not differ significantly between trout and carp hepatocytes, but the predicted BCF values were significantly higher in trout than in carp. In contrast, the measured in vivo BCF values did not differ significantly between the two species. A possible explanation of this discrepancy is that the existing in vitro-in vivo prediction models are parameterized only for trout but not for carp. Therefore, future research needs to develop species-specific extrapolation models.
Lower Bounds on Common Knowledge in Distributed Algorithms

20. Ol S T RI B U T I O N / A V A I L A B I L I T Y OF A B S T R A C T 21. A B S T R A C T S E C U R I T Y C L A S S I F I C A T I O N U N C L A S S I F I E D / U N L I M I T E D 3 S A M E AS RPT. □ O T I C U SER S □ UNCLASSIFIED 22a. N A M E O F R E S P O N S IB L E I N D I V I D U A L ______________________________________________ 22b. t e l e p h o n e n u m b e r (Include Area Code) 22c. O F F I C E S Y M B O L NONE DD FORM 1473, 33 APR e d i t i o n o f i j a n 73 is o b s o l e t e . UNCLASSIFIED S E C U R I T Y C L A S S I F I C A T I O N O F T H IS P A G E SECUR ITY CLASSI FIÇA TIO N OF TH IS PAGE
Complex karyotype in acute promyelocytic leukemia

Acute Promyelocytic leukemia (APL) is characterized by typical morphological features, t(15;17) translocation and active response to all-trans retinoic acid (ATRA) in the great majority of patients. However, a subset of APL cases may present with atypical phenotypic, cytogenetic or molecular features at different stages of the disease. The biological and clinical significance of these features sometimes remains obscure [1]. Amongst APL patients with atypical cytogenetic features, in addition to t(15;17), other chromosome abnormalities are also found either at the time of diagnosis or at relapse, with the incidence ranging from 29% to 43% in previous reports. Trisomy 8 was the most frequent secondary change reported in many studies [2]. Although t(15;17) is considered to be a favorable cytogenetic feature, however, the prognostic significance of additional cytogenetic abnormalities (ACA) in APL has remained a matter of debate.
Evolving Invasive Neonatal Systemic Candidiasis, a Review

1Consultant Neonatologist, Neonatal Intensive Care Unit, Pediatric Department, Latifa Women & Children Hospital, Dubai Health Authority, UAE 2Consultant Neonatologist and Head of Pediatric Department & Neonatal Intensive Care Unit, Latifa Women & Children Hospital, Dubai Health Authority, UAE 3Specialist Senior Registrar, Neonatal Intensive Care Unit, Pediatric Department, Latifa Women & Children Hospital, Dubai Health Authority, UAE 4Specialist Registrar, Neonatal Intensive Care Unit, Pediatric Department, Latifa Women & Children Hospital, Dubai Health Authority, UAE
The use of library software in Nigerian University Libraries and challenges

projects. Unfortunately, the software was abandoned due to lack of adequate maintenance support and technical guidance. These libraries have made attempts to use other software including GLAS, X-LIB, VIRTUA and ALICE. Libraries need software that is well supported and used by many other libraries with the hope of forming a user group to support common problems and offer solutions that would lead to continuing improvements (Adekonye, 2011). Today academic libraries in Nigeria have greater demands for effective library information management systems (Koneru, 2005). Library automation systems today require considerable programming skills together with an extensive knowledge of functional needs and standards. Most automation efforts in Nigerian academic libraries have failed due to lack of feasibility studies and are still searching for appropriate software. Okentunji (2008) pointed out that software selection is not an easy task for libraries. This has given rise to high software turnover in Nigerian library automation projects. This study, therefore, seeks to survey the use of library software in Nigerian university libraries and to identify associated challenges. Research questions RQ1. What type of library software do university libraries in Nigeria use for library operations? RQ2. What are the purposes for which
Correlation of quantitative HBSAG with quantitative HBV DNA in different phases of chronic hepatitis b (CHB) patients

Background: Quantitative HBsAg (qHBsAg) level is increasingly recognized as an important marker in the course of HBV infection; however, its role in natural history of disease is still unclear. Aim: To study the baseline serum qHBsAg level and its association with quantitative HBV DNA levels in different phases of Indian chronic hepatitis B (CHB) patients. Materials: We conducted cross-sectional study of consecutive 120 CHB patients (mean age 37 [SD 13] years, 67% males). HBV DNA was measured by RT PCR and serum qHBsAg levels by Abott Architect Assay. Results: 90.8% were HBe-negative patients. Median serum qHBsAg of study cohort was 3.74 log10 IU/mL. Overall correlation between qHBsAg levels and HBV DNA levels was weak (spearmen r= 0.298) and also in HBe-negative patients (r= 0.179). Patient having qHBsAg/HBV DNA ratio > 49.09 have shown good correlation between qHBsAg levels and HBV DNA levels. Conclusion: Quantitative HBsAg level was widely distributed among the different phases of CHB. Serum qHBsAg may not replace serum HBV DNA test in majority of adult CHB population which are mainly in HBe-negative low replicate stage.
Morbidity Pattern among Out-Patients Attending Urban Health Training Centre in Srinagar

The current study was designed to identify the morbidity pattern of out-patients attending Urban Health Training Centre in an urban area of a medical college in Srinagar, Pauri Garhwal district, Uttarakhand, North India. The present study record-based retrospective study was conducted among the out-patients attending the regular clinic at the Urban Health Training Centre, of a medical college in Srinagar city of Uttarakhand State of North India during the study period of one year in 2014. Data was retrieved from the OPD registers maintained at the clinic. Data was collected pertaining to socio-demographic profile, morbidity details and treatment pattern. Diseases were identified using the International Classification of Diseases (ICD-10) code. Descriptive analysis was done. During the study period, a total of 9343 subjects attended the OPD. Among them, majority of them (60%) were females. More than half (56 %) belonged to the age group of 35-65 year age-group. The association of disease classification was found to be statistically significant with respect to gender. The leading morbidity of communicable disease was found to be certain infectious and parasitic diseases especially Typhoid whereas musculoskeletal system and connective tissue disorders were the most common cause among morbidity due to NCDs. Out of all, typhoid was found to cause maximum of morbidity among the subjects. The present study highlights the morbidity pattern of communicable and NCDs among the population of hilly areas of Garhwal, Uttarakhand India. Priority should be preferred for the regular tracking of diseases in terms of preventive and promotive aspects. Morbidity in the out- door clinics reflects the emerging trend of mixed disease spectrum burden comprising communicable and non-communicable diseases.
A School—University Collaborative Journey Toward Relevance and Meaning in an Urban High School Physical Education Program

The promise and potential for collaborative teams of school and university colleagues to address substantive issues in physical education were the focus of an international conference and a series of high-profile articles in the late 80s and early 90s. However, school-university partnerships have seldom focused on school reform. Few scholars address secondary school physical education, save for the occasional article describing its eminent demise. Successful implementation of innovative practices, such as curricular and instructional revisions, requires significant investments in teacher development. This paper details a specific collaborative effort in physical education that makes a case for systematic long-term commitments to improve young people's physical education experiences. Stories from a 4-year collaborative highlight the complexities and challenges faced by any subdisciplinary group that commits to connecting professional preparation and practice for the benefit of our respective constituencies.
[Food groups consumption and sociodemographic characteristics in Mexican population].

OBJECTIVE To estimate the recommendable and non-recommendable food groups for usual consumption by sociodemographic characteristics in Mexican population. MATERIALS AND METHODS Through a 7-day, semi-quan¬titative food frequency questionnaire used in 2016 National Health and Nutrition Survey, we estimated the proportions of population (preschool and school children, adolescents and adults) who consumed food groups that are relevant for public health by area, region and socioeconomic status (SES). RESULTS Less than 50% of population consumed vegetables daily; almost 80% of the population consumed plain water daily and sweetened beverages (3 d/week). Center and Mexico City regions had the highest percentage of fruits and vegetables consumers (p<0.012). High SES had the highest consumer´s percentage of recommendable and non-recommendable food groups. CONCLUSIONS A high percentage of the population do not consume fruits, vegetables and plain water daily.