Miracle-dz/UniFAR-FTUs huggingface dataset:
Close relationships and diabetes management across the lifespan: The good, the bad, and autonomy

Relationships are linked with positive and negative self-management and illness outcomes for individuals with type 1 diabetes. Explanations for these mixed associations have remained separated in psychosocial research in type 1 diabetes by relationship type (e.g. parent vs spouse) and individual’s age (e.g. adolescence vs older adulthood). In this conceptual review, we present a novel perspective that close relationships across the lifespan may be beneficial for illness self-management when they support individuals’ sense of autonomy, defined from a Basic Psychological Needs perspective. Processes of autonomy support are crucial for promoting illness management across all ages and relationship types.
Maternal Responsiveness Protects Exuberant Toddlers From Experiencing Behavior Problems in Kindergarten

ABSTRACT Research Findings: Exuberant temperament, characterized by high approach and positive affect, is linked to socioemotional outcomes including risk of externalizing symptoms across development. Externalizing problems interfere with children’s school readiness and lead to disruptive behavior in the classroom. While some moderating factors help identify which exuberant children are at risk and in which contexts they are at risk, few studies have identified early moderators that protect against maladjustment when children enter school. In the current study, we examined exuberant temperament in 124 toddlers and classroom behavior problems reported by kindergarten teachers. We also assessed the impact of maternal responsiveness at 24 months on the relation between exuberance and classroom behavior problems. As hypothesized, we found that higher exuberance predicted more behavior problems. In addition, maternal responsiveness moderated this association such that high responsiveness protected exuberant children from classroom behavior problems. Practice or Policy: These results expand our understanding of socioemotional risks for exuberant children and how these risks influence school readiness. We also find that maternal responsiveness during toddlerhood mitigates these risks, and our findings suggest that interventions for exuberant children at risk for behavior problems or poor school readiness should target parental responsiveness when children are toddlers.
Fully automatic robust adaptive beamforming using the constant modulus feature

The diagonal loading (DL) technique is the most widely used method to improve the robustness of the Capon beamformer in the presence of imprecise knowledge of the covariance matrix and the desired signal's steering vector. The selection of the DL level is challenging in practice and might depend on some user-defined parameters which are possibly hard to be determined. A fully automatic and training-free method for the DL level selection is herein presented to extract the desired signal with constant modulus, which is a common feature for communication signals. Simulated results of the beamforming performance have demonstrated the efficacy of the proposed method.
Global expression profiling of metabolic pathway‐related lncRNAs in human gastric cancer and the identification of RP11‐555H23.1 as a new diagnostic biomarker

Long noncoding RNAs (lncRNAs) have roles in regulating metabolism; however, the global expression profile of metabolic pathway‐associated lncRNAs in gastric cancer is unknown. The purpose of our study was to examine metabolic pathway‐related lncRNAs in gastric cancer and their possible diagnostic values.
The good, the bad, and the ugly: Bayesian model selection produces spurious posterior probabilities for phylogenetic trees.

The Bayesian method is noted to produce spuriously high posterior probabilities for phylogenetic trees in analysis of large datasets, but the precise reasons for this over-confidence are unknown. In general, the performance of Bayesian selection of misspecified models is poorly understood, even though this is of great scientific interest since models are never true in real data analysis. Here we characterize the asymptotic behavior of Bayesian model selection and show that when the competing models are equally wrong, Bayesian model selection exhibits surprising and polarized behaviors in large datasets, supporting one model with full force while rejecting the others. If one model is slightly less wrong than the other, the less wrong model will eventually win when the amount of data increases, but the method may become overconfident before it becomes reliable. We suggest that this extreme behavior may be a major factor for the spuriously high posterior probabilities for evolutionary trees. The philosophical implications of our results to the application of Bayesian model selection to evaluate opposing scientific hypotheses are yet to be explored, as are the behaviors of non-Bayesian methods in similar situations.
Prognostic impact of right bundle branch block in hospitalized patients with idiopathic dilated cardiomyopathy: a single-center cohort study

Objective Idiopathic dilated cardiomyopathy (IDCM) is a primary myocardial disease resulting in symptoms of heart failure. Right bundle branch block (RBBB) is associated with increased cardiovascular risk and all-cause mortality. Therefore, the present study was performed to identify the prognostic impact of RBBB in patients with IDCM. Methods In total, 165 hospitalized patients with IDCM were evaluated. Receiver operating characteristic curve analysis was used to determine the cutoff point, and Cox regression was used to assess risk factors. Results After a median follow-up of 73.1 months (interquartile range, 36.1–88.7 months), 59 (35.8%) patients had died. All-cause mortality was significantly higher in patients with than without RBBB (log-rank χ2 = 9.400), P<0.05. Significant independent predictors of all-cause mortality in patients with IDCM were RBBB (hazard ratio, 2.898; 95% confidence interval, 1.201–6.995) and the left ventricular end-diastolic dimension (LVEDD) (hazard ratio, 1.034; 95% confidence interval, 1.004–1.066) at admission. Patients with RBBB and an LVEDD of ≥63 mm had the highest mortality (log-rank χ2 = 14.854), P<0.05. Conclusion RBBB was an independent predictor of all-cause mortality, and the combination of RBBB and LVEDD provided more clinically relevant information than RBBB alone for assessing the risk of all-cause mortality in patients with IDCM.
A high‐speed RSD‐based flexible ECC processor for arbitrary curves over general prime field

This workpresents a novel high‐speed redundant‐signed‐digit (RSD)‐based elliptic curve cryptographic (ECC) processor for arbitrary curves over a general prime field. The proposed ECC processor works for any value of the prime number and curve parameters. It is based on a new high speed Montgomery multiplier architecture which uses different parallel computation techniques at both circuit level and architectural level. At the circuit level, RSD and carry save techniques are adopted while pre‐computation logic is incorporated at the architectural level. As a result of these optimization strategies, the proposed Montgomery multiplier offers a significant reduction in computation time over the state‐of‐the‐art. At the system level, to further enhance the overall performance of the proposed ECC processor, Montgomery ladder algorithm with (X,Y)‐only common Z coordinate (co‐Z) arithmetic is adopted. The proposed ECC processor is synthesized and implemented on different Xilinx Virtex (V) FPGA families for field sizes of 256 to 521 bits. On V‐6 platform, it computes a single 256 to 521 bits scalar point multiplication operation in 0.65 to 2.6 ms which is up to 9 times speed‐up over the state‐of‐the‐art.
Does Stress Explain the Effect of Sleep on Self-Control Difficulties? A Month-Long Daily Diary Study

Insufficient sleep is linked to increased stress and suboptimal self-control; however, no studies have examined stress as a reason for why sleep affects self-control. Moreover, it is unknown if there are individual differences that make people vulnerable to this dynamic. Daily diary entries from 212 university students across 30 days were used in a multilevel path model examining if stress explained how prior night sleep affected next-day self-control difficulties and exploring if individual differences in sleep duration, stress, or self-control qualified this effect. Increased stress partially mediated of the effect of reduced sleep duration on increased next-day self-control difficulty. Moreover, short sleep increased next-day stress more for individuals with higher typical stress. Daytime stress especially amplified self-control difficulty for individuals with shorter typical sleep duration. Findings implicate stress as a substantial factor in how sleep loss undermines self-control and identify individuals particularly susceptible to this effect.
Comprehensive Longitudinal Microbiome Analysis of the Chicken Cecum Reveals a Shift From Competitive to Environmental Drivers and a Window of Opportunity for Campylobacter

Chickens are a key food source for humans yet their microbiome contains bacteria that can be pathogenic to humans, and indeed potentially to chickens themselves. Campylobacter is present within the chicken gut and is the leading cause of bacterial foodborne gastroenteritis within humans worldwide. Infection can lead to secondary sequelae such as Guillain-Barré syndrome and stunted growth in children from low-resource areas. Despite the global health impact and economic burden of Campylobacter, how and when Campylobacter appears within chickens remains unclear. As such, there has been a motivation to decrease the number of Campylobacter within chickens and thus reduce the risk of infection to humans. The lack of day-to-day microbiome data with replicates, relevant metadata, and a lack of natural infection studies have delayed our understanding of the chicken gut microbiome and Campylobacter. Here, we performed a comprehensive day-to-day microbiome analysis of the chicken cecum from day 3 to 35 (12 replicates each day; n=396) combining metadata such as chicken weight and feed conversion rates to investigate what the driving forces are for the microbial changes within the chicken gut over time, and how this relates to Campylobacter appearance within a natural habitat setting. We found a rapidly increasing microbial diversity up to day 12 with variation observed both in terms of genera and abundance, before a stabilisation of the microbial diversity after day 20. In particular, we identified a shift from competitive to environmental drivers of microbial community from days 12 to 20 creating a window of opportunity whereby Campylobacter appears. Campylobacter was identified at day 16 which was one day after the most substantial changes in metabolic profiles observed. In addition, microbial variation over time is most likely influenced by the diet of the chickens whereby significant shifts in OTU abundances and beta dispersion of samples often corresponded with changes in feed. This study is unique in comparison to the most recent studies as neither sampling was sporadic nor Campylobacter was artificially introduced, thus the experiments were performed in a natural setting. We believe that our findings can be useful for future intervention strategies and can help elucidate the mechanism through which Campylobacter within chickens can be reduced.
Protecting the gains: What changes are needed to prevent a reversal of the downward cardiovascular disease mortality trend?

Cardiovascular disease (CVD) mortality has decreased over 60% over the past 50 years in the United States; however, emerging data indicate CVD incidence may be rising because of shifting demographics, increasing risk factor prevalence, and competing needs for limited resources. We projected CVD mortality from 2015 to 2040 given varying informed assumptions regarding changes in risk factor prevalence, uptake of current therapeutic options, and future innovations.
A dual role of cholesterol in osteogenic differentiation of bone marrow stromal cells

Osteoblasts, the chief bone‐forming cells, are differentiated from mesenchymal stromal/stem cells. Disruption of this differentiation process can cause osteoporosis, a bone disease characterized by low bone mass and deteriorated bone structure. Cholesterol has been implicated in pathogenesis of osteoporosis, and was recently identified as an endogenous activator of Hedgehog (Hh) signaling. However, its pathological and physiological roles in osteoblast differentiation are still poorly understood. Moreover, it is unclear whether these potential roles played by cholesterol are related to its capability to modulate Hh pathway. In this study, we investigated the role of exogenous versus endogenous cholesterol in osteogenesis and Hh pathway activation using ST2 cells, a bone marrow stromal cell line. We found that exogenous cholesterol significantly inhibited alkaline phosphatase (ALP) activity and messenger RNA expression of osteoblast markers genes (Alpl, Sp7, and Ibsp) while modestly activating expression of Gli1 (a readout of Hh signaling) under both basal osteogenic culture condition and Wnt3a treatment. Similarly, exogenous cholesterol suppressed osteogenic response of ST2 cells to sonic Hh (Shh) or purmorphamine (Purmo) treatment, which, however, was accompanied by diminished induction of Gli1, indicating the involvement of a Hh‐dependent mechanism. Interestingly, depletion of endogenous cholesterol also reduced Shh‐induced ALP activity and Gli1 expression. Likewise, cholesterol depletion inhibited osteogenic response to Purmo, although it did not affect Gli1 induction. Taken together, our findings have demonstrated that cholesterol plays a dual role in osteoblast differentiation likely through both Hh‐dependent and ‐independent mechanisms.
Glucose intolerance in monosodium glutamate obesity is linked to hyperglucagonemia and insulin resistance in α cells

Obesity predisposes to glucose intolerance and type 2 diabetes (T2D). This disease is often characterized by insulin resistance, changes in insulin clearance, and β‐cell dysfunction. However, studies indicate that, for T2D development, disruptions in glucagon physiology also occur. Herein, we investigated the involvement of glucagon in impaired glycemia control in monosodium glutamate (MSG)‐obese mice. Male Swiss mice were subcutaneously injected daily, during the first 5 days after birth, with MSG (4 mg/g body weight [BW]) or saline (1.25 mg/g BW). At 90 days of age, MSG‐obese mice were hyperglycemic, hyperinsulinemic, and hyperglucagonemic and had lost the capacity to increase their insulin/glucagon ratio when transitioning from the fasting to fed state, exacerbating hepatic glucose output. Furthermore, hepatic protein expressions of phosphorylated (p)‐protein kinase A (PKA) and cAMP response element‐binding protein (pCREB), and of phosphoenolpyruvate carboxykinase (PEPCK) enzyme were higher in fed MSG, before and after glucagon stimulation. Increased pPKA and phosphorylated hormone‐sensitive lipase content were also observed in white fat of MSG. MSG islets hypersecreted glucagon in response to 11.1 and 0.5 mmol/L glucose, a phenomenon that persisted in the presence of insulin. Additionally, MSG α cells were hypertrophic displaying increased α‐cell mass and immunoreactivity to phosphorylated mammalian target of rapamycin (pmTOR) protein. Therefore, severe glucose intolerance in MSG‐obese mice was associated with increased hepatic glucose output, in association with hyperglucagonemia, caused by the refractory actions of glucose and insulin in α cells and via an effect that may be due to enhanced mTOR activation.
Prevalence and comorbidities of dementia in Israel: A nationally representative cohort study

ABSTRACT Information on the prevalence of dementia is rare in the Middle East, including dementia comorbidities with diabetes, ischemic heart disease (IHD), diabetes, and severe mental illnesses (SMI). This study aims to examine the 1-year prevalence of dementia and the aforementioned comorbidities in a representative national Israeli cohort aged 60 and above. The study design was a nationally representative cohort. The source sample comprised 122,829 persons aged 60 and above in 2015. The dementia group consisted of 8,153 patients (6.6%). The rate of dementia approximately doubled for every 5 years of maturation to the age of 84, and dropped thereafter. Dementia was significantly (P < 0.0001) more likely among women (N = 4,899, 7.4%) than men (N = 3,254, 5.7%). Based on multivariate logistic regression models, the group with dementia compared with the group without dementia had statistically significant (P < 0.001) lower odds of diabetes (OR = 0.78) and IHD (OR = 0.87), and significantly higher odds of SMI (OR = 4.96), accounting for age and gender. The prevalence of dementia delineated by age and gender in Israel resembles those found in other developed nations. Generally, dementia was associated with more SMI and less IHD and diabetes.
Creating a safe space for First Nations youth to share their pain

Introduction: Indigenous children and youth may be quiet about the way they express their pain and hurt which is in contrast to how health professionals are trained to assess it. Objectives: The aim was to understand how youth from 4 First Nation communities express pain using narratives and art-based methods to inform culturally appropriate assessment and treatment. Methods: This qualitative investigation used a community-based participatory action methodology to recruit 42 youth between 8 and 17 years of age to share their perspectives of pain using ethnographic techniques including a Talking Circle followed by a painting workshop. Physical pain perspectives were prominent in circle conversations, but emotional pain, overlapping with physical, mental, and spiritual pain perspectives, was more evident through paintings. Art themes include causes of pain and coping strategies, providing a view into the pain and hurt youth may experience. Youth were more comfortable expressing emotional and mental pain through their artwork, not sharing verbally in conversation. Results: Circle sessions and artwork data were themed using the Indigenous Medicine Wheel. Content of the circle conversations centered on physical pain, whereas paintings depicted mainly emotional pain (eg, crying or loneliness; 74% n = 31) with some overlap with physical pain (eg, injuries; 54%), mental pain (eg, coping strategies; 31%), and spiritual pain (eg, cultural symbols; 30%). Common threads included hiding pain, resilience, tribal consciousness, persistent pain, and loneliness. Conclusion: Once a safe space was created for First Nation youth, they provided a complex, culturally based understanding of the pain and coping experience from both an individual and community perspective. These engaging, culturally sensitive research methods provide direction for health providers regarding the importance of creating a safe space for young people to share their perspectives.
Learning Design Semantics for Mobile Apps

Recently, researchers have developed black-box approaches to mine design and interaction data from mobile apps. Although the data captured during this interaction mining is descriptive, it does not expose the design semantics of UIs: what elements on the screen mean and how they are used. This paper introduces an automatic approach for generating semantic annotations for mobile app UIs. Through an iterative open coding of 73k UI elements and 720 screens, we contribute a lexical database of 25 types of UI components, 197 text button concepts, and 135 icon classes shared across apps. We use this labeled data to learn code-based patterns to detect UI components and to train a convolutional neural network that distinguishes between icon classes with 94% accuracy. To demonstrate the efficacy of our approach at scale, we compute semantic annotations for the 72k unique UIs in the Rico dataset, assigning labels for 78% of the total visible, non-redundant elements.
Autophagy-dependent release of zinc ions is critical for acute lung injury triggered by zinc oxide nanoparticles

Abstract Pulmonary exposure to zinc oxide nanoparticles (ZnONPs) could cause acute lung injury (ALI), but the underlying molecular mechanism remains unclear. Herein, we established a ZnONPs-induced ALI mouse model, characterized by the histopathological changes (edema and infiltration of inflammatory cells in lung tissues), and the elevation of total protein and cytokine interleukin-6 in bronchoalveolar lavage fluid in time- and dose-dependent manners. This model also exhibited features like the disturbance of redox-state (reduced of glutathione to glutathione disulfide ratio, elevation of heme oxygenase-1 and superoxide dismutase 2), the decrease of adenosine triphosphate synthesis and the release of zinc ions in the lung tissues. Interestingly, we found that ZnONPs exposure caused the accumulation of autophagic vacuoles and the elevation of microtubule-associated proteins 1A/1B light chain (LC)3B-II and p62, indicating the impairment of autophagic flux. Our data indicated that the above process might be regulated by the activation of AMP-activated protein kinase but not the mammalian target of rapamycin pathway. The association between ZnONPs-induced ALI and autophagy was further verified by a classical autophagy inhibitor, 3-methyladenine (3-MA). 3-MA administration reduced the accumulation of autophagic vacuoles, the expression of LC3B-II and p62, followed by a significant attenuation of histopathological changes, inflammation, and oxidative stress. More importantly, 3-MA could directly decrease the release of zinc ions in lung tissues. Taken together, our study provides the evidence that ZnONPs-induced pulmonary toxicity is autophagy-dependent, suggests that limiting the release of zinc ions by inhibiting autophagy could be a feasible strategy for the prevention of ZnONPs-associated pulmonary toxicity.
Prospective Determination of the Incidence and Risk Factors of New‐Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort

Identification of the incidence of juvenile idiopathic arthritis (JIA)–associated uveitis and its risk factors is essential to optimize early detection. Data from the Research in Arthritis in Canadian Children Emphasizing Outcomes inception cohort were used to estimate the annual incidence of new‐onset uveitis following JIA diagnosis and to identify associated risk factors.
“My future is bright…I won't die with the cause of AIDS”: ten‐year patient ART outcomes and experiences in South Africa

South Africa is moving into a new era of HIV treatment with “treat all” policies where people may be on treatment for most of their lives. We need to understand treatment outcomes and facilitators of long‐term antiretroviral treatment (ART) adherence and retention‐in‐care in the South African context. In one of the first studies to investigate long‐term treatment outcomes in South Africa, we aimed to describe ten‐year patient outcomes at a large public‐sector HIV clinic in Johannesburg and explore patient experiences of the treatment programme over this time in order to ascertain factors that may aid or hinder long‐term adherence and retention.