Miracle-dz/UniFAR-FTUs huggingface dataset:
Active Involvement of End Users When Developing Web-Based Mental Health Interventions

Background Although many web-based mental health interventions are being released, the actual uptake by end users is limited. The marginal level of engagement of end users when developing these interventions is recognized as an important cause for uptake problems. In this paper, we offer our perceptive on how to improve user engagement. By doing so, we aim to stimulate a discourse on user involvement within the field of online mental health interventions. Methods We shortly describe three different methods (the expert-driven method, intervention mapping, and scrum) that were currently used to develop web-based health interventions. We will focus to what extent the end user was involved in the developmental phase, and what the additional challenges were. In the final paragraph, lessons learned are summarized, and recommendations provided. Results Every method seems to have its trade-off: if end users are highly involved, availability of end users and means become problematic. If end users are less actively involved, the product may be less appropriate for the end user. Other challenges to consider are the funding of the more active role of technological companies, and the time it takes to process the results of shorter development cycles. Conclusion Thinking about user-centered design and carefully planning, the involvement of end users should become standard in the field of web-based (mental) health. When deciding on the level of user involvement, one should balance the need for input from users with the availability of resources such as time and funding.
The drainage of a foam lamella

We present a mathematical model for the drainage of a surfactant-stabilized foam lamella, including capillary, Marangoni and viscous effects and allowing for diffusion, advection and adsorption of the surfactant molecules. We use the slender geometry of a lamella to formulate the model in the thin-film limit and perform an asymptotic decomposition of the liquid domain into a capillary-static Plateau border, a time-dependent thin film and a transition region between the two. By solving a quasi-steady boundary-value problem in the transition region, we obtain the flux of liquid from the lamella into the Plateau border and thus are able to determine the rate at which the lamella drains. Our method is illustrated initially in the surfactant-free case. Numerical results are presented for three particular parameter regimes of interest when surfactant is present. Both monotonic profiles and those exhibiting a dimple near the Plateau border are found, the latter having been previously observed in experiments. The velocity field may be uniform across the lamella or of parabolic Poiseuille type, with fluid either driven out along the centreline and back along the free surfaces or vice versa. We find that diffusion may be negligible for a typical real surfactant, although this does not lead to a reduction in order because of the inherently diffusive nature of the fluid–surfactant interaction. Finally, we obtain the surprising result that the flux of liquid from the lamella into the Plateau border increases as the lamella thins, approaching infinity at a finite lamella thickness.
Report on 42 Cases of Postirradiation Lesions of the Brachial Plexus and Their Treatment

Here we report 42 cases of postirradiation lesions of the brachial nerve plexus in patients treated with radiotherapy after radical mastectomy. These lesions usually appeared at least 1 year after treatment, and motorial disturbances always developed, even if initially they may have been absent. A comparison of the case material indicates that a reduction in the dose administered to the supraclavicular region and exclusion of the axillary region from the treatment resulted in a significant reduction in the incidence of these lesions. In fact, in a group of 490 patients treated by the old radiotherapy method at the Istituto Nazionale Tumori of Milan (i.e., administration of 6000 rad to the brachial nerve plexus), 16 cases of lesions at this plexus were observed. In a group of 200 patients treated instead with a new method (i.e., administration of 4900 rad to the brachial nerve plexus and exclusion of the axillary region), no nerve lesions were observed, with significance levels, according to Fisher's test, less than 0.9 %. Since radiolesions at the brachial nerve plexus have a very bad prognosis with regard to functioning of the limb and physiotherapy is of little help, this new therapeutic method is very useful, and it is not accompanied by an increase in the number of local recurrences as compared to the old method.
Immune responses to an upper body tri‐set resistance training session

The purpose of this study was to evaluate the acute immune responses to an upper body tri‐set resistance training (RT) session in RT trained individuals. Eighteen young trained men (22·0 ± 1·8 years) were randomly assigned to an exercise group (EG; n = 9) or control group (CG; n = 9). The EG completed an acute tri‐set RT protocol using two combinations of three exercises for the same muscle group with six to eight repetitions at 75% of one repetition maximum (1RM) for each exercise. Blood samples were collected before (Pre), and 15 min (Post) and 24 h (P24h) after the acute RT protocol to determine basal and acute total leucocytes and leucocyte subsets counting, interleukin‐6 (IL‐6), tumour necrosis factor‐α (TNF‐α) and cortisol. There were significant increases in total leucocytes, monocytes and neutrophils at Post as compared with Pre (P<0·05). Additionally, total leucocytes and monocytes were reduced even at P24h when compared to Pre (P<0·05). There were no significant changes in plasma concentrations of TNF‐α, IL‐6 and cortisol throughout the measured moments. As compared to CG, EG demonstrated very large effect sizes for total leucocytes, neutrophils and monocytes 15 min postprotocol and a reduction (trivial and small effect sizes) P24h. These results suggest that the tri‐set RT session did not exacerbate the acute inflammatory response and might be a good option for variations in RT methods for trained individuals.
FDG and L-[1-11C]-tyrosine imaging of soft-tissue tumors before and after therapy.

UNLABELLED This study was undertaken to investigate the relationship of PET using fluorodeoxyglucose (FDG) or L-[1-11C]-tyrosine (TYR) with histopathologic findings in soft-tissue tumors, before and after therapy. Histopathologic parameters that were studied were tumor grade, mitotic rate, proliferation activity and amount of necrosis. METHODS PET with either FDG or TYR was performed in 55 patients with a lesion suspected to be a malignant soft-tissue tumor. In 28 patients, a second PET study was performed after therapy. Metabolic rate of glucose consumption (MRglc) and protein synthesis rate (PSR) were calculated. Histologic parameters were obtained from a biopsy specimen that was taken just after the first PET study and from the tumor remnant that was resected after therapy. RESULTS MRglc correlated with tumor grade (r = 0.71) and mitotic rate (r = 0.68) but not with proliferation or necrosis. After therapy, there was no longer a correlation with mitotic rate. PSR correlated with tumor grade (r = 0.53), mitotic rate (r = 0.73) and proliferation (r = 0.66). After therapy, correlation with mitosis and proliferation had improved, and a negative correlation was found between PSR and necrosis (r = -0.74). CONCLUSION These results validate the use of both FDG and TYR to give an in vivo indication of histologic tumor parameters. However, FDG gives a better indication of tumor grade, whereas TYR is more accurate in predicting mitotic rate and proliferation, especially after therapy. FDG may therefore not be the most suited tracer for monitoring therapy. TYR might be more appropriate for that purpose.
Applying an Efficiency Measure of Desirable and Undesirable Outputs in DEA to U.S. Electric Utilities

The measure proposed in this paper is a new nonparametric data envelopment analysis (DEA) scheme, the hybrid measure, for determining efficiency in the presence of radial and nonradial inputs or outputs. Further extension of the scheme occurred to address nonseparable desirable and undesirable outputs. Applying the model to measure the overall efficiency of U.S. electric utilities in the presence of both desirable and undesirable outputs indicated that the utilities had improved their overall management and environmental efficiency between 1996 and 2000.
Nutritional paradigms of ovine fetal growth restriction: Implications for human pregnancy

Low birth weight and prematurity are associated with short inter-pregnancy intervals, low pre-pregnancy weights, insufficient maternal weight gains during pregnancy, multifetal pregnancies and a young maternal age. Improvements in maternal nutritional status are arguably imperative for ensuring an appropriate pregnancy outcome in these vulnerable groups, but ethical boundaries limit these investigations. Experimental paradigms using the pregnant sheep have been widely used to identify the nutritionally sensitive periods of conceptus development. In adult sheep, severe undernutrition during the periconceptual period accelerates maturation of the fetal hypothalamic-pituitary adrenal axis and results in pre-term delivery. Low pre-pregnancy weight, followed by undernutrition during mid-pregnancy, results in reduced placental growth and lower birth weights at term. Studies that have restricted nutrients during mid-gestation only reveal variable effects on the placental and fetal growth trajectory, however if undernutrition is prolonged during late-pregnancy, fetal growth is compromised, particularly in twin pregnancies. In contrast, overnourishing the adolescent sheep to promote rapid maternal growth, results in the premature delivery of low birth weight lambs. These effects are mediated by impaired placental growth, uteroplacental blood flows and fetal nutrient uptakes. At the other end of the nutritional spectrum, undernourishing the adolescent sheep to gradually deplete nutrient reserves, results in fetal growth restriction which is independent of alterations in placental mass.
Fibromyalgia prevalence and related factors in a large registry of patients with systemic lupus erythematosus.

OBJECTIVES The objective of this study is to determine the prevalence of fibromyalgia (FM) in systemic lupus erythematosus (SLE) patients and to study its relationship to depression and other SLE-related factors. METHODS A cross-sectional data analysis from the RELESSER-Transversal Spanish Registry, which includes SLE patients in a national multicentre retrospective charts review, was performed. INCLUSION CRITERIA patients who fulfilled ≥4 ACR 1997 SLE criteria. Main variables were disease duration, depression, sociodemographics, comorbidities, SLE activity symptoms, serological findings, therapies and different disease status indices. Statistical analyses included a descriptive, associative and logistic regression analyses. A literature review was performed. RESULTS 3,591 SLE patients were included, 90.1% women, 34.6 years of age at diagnosis (SD 14.6 years) and 93.1% Caucasians. FM prevalence was 6.2%. SLE patients with disease duration >5 years showed more FM than those with duration <5 years: 6.9% vs. 4.0%, respectively (p<0.05). SLE-FM patients showed higher prevalence of depression compared to non-FM-SLE patients: 53.1% vs. 14.6%, respectively (p<0.001). After adjusting by risk factors, the OR (CI) of suffering depression in FM-SLE patients was 6.779 (4.770-9.636), p<0.001. The OR of having secondary Sjögren's 2.447 (1.662-3.604), p<0.001, photosensitivity 2.184 (1.431-3.334), p<0.001, and oral ulcers 1.436 (1.005-2.051), p=0.047. CONCLUSIONS Prevalence of FM in Caucasian SLE patients was high compared to the general population, and was significantly higher in those in later stages of disease. SLE patients with depression showed a strong risk of developing FM. Photosensitivity, oral ulcers and secondary Sjögren's were the only SLE-related factors associated with FM.
A Complexity Approach to Sustainability - Theory and Application

A major challenge of our times is to understand and manage the increasing complexity of socio-economic reality. This has immediate relevance for sustainable development. The impact of recent contributions from systems and complexity sciences in addressing this issue has not filtered down into effective practice -- notably, there remain problems caused by the legacy of competing paradigms and the application of their associated methodologies. This book argues the urgency for the application of analytical tools that embody the principles of complexity management. The authors describe a theoretical framework based on complexity science with a focus on organisational and second order cybernetics, one that presents a powerful new insight into the concept of sustainability. The book also describes actual applications of the ideas in the area of organisational, societal and environmental management, and reflects upon the impact of such an approach on current practice.
Aortic distensibility in normotensive, untreated and treated hypertensive patients.

BACKGROUND Compared with normotensive subjects, untreated hypertensive patients show a decrease of their aortic distensibility. Whether antihypertensive treatment, by reducing blood pressure and changing functional and/or structural abnormalities of the arterial wall, may prevent or reverse the arterial damage due to the accelerated ageing process remains unclear. The objective of the present study was to determine, using a cross-sectional approach, whether aortic distensibility as measured by pulse wave velocity, in treated hypertensive patients whose diastolic blood pressure had been normalised for several months, was significantly improved over that of untreated hypertensive patients. METHODS Carotid femoral pulse wave velocity was measured in 124 normotensive subjects and 388 hypertensive patients. The latter group included 164 treated patients with well controlled diastolic blood pressure and 224 untreated hypertensive subjects. The three groups did not differ in other cardiovascular risk factors. RESULTS In each group there was a significant relationship between age and pulse wave velocity. When compared with untreated hypertensives, treated hypertensives with well controlled diastolic blood pressure had significantly lower blood pressure and pulse wave velocity according to age. However, although diastolic blood pressure of well controlled hypertensives was not significantly different from that of normotensive subjects, the aortic distensibility of the controlled hypertensives remained reduced showing two characteristics: a faster increase in pulse wave velocity with age and a negative relationship with HDL-cholesterol. CONCLUSION These results suggest that long-term antihypertensive treatment and control of blood pressure using only diastolic blood pressure criteria may not fully reverse arterial alteration associated with hypertensive vascular disease.
Staged Treatment of High Energy Midfoot Fracture Dislocations

Background: Staged care with interval external fixation is a successful established treatment strategy for high energy periarticular fractures with often extensive soft tissue damage such as the tibial plateau and plafond. The aim of the current study was to determine whether staged care of high energy midfoot fracture/dislocation with interval external fixation prior to definitive open reconstruction in the polytraumatized patient was both safe and efficacious. Methods: One hundred twenty-three patients were operated on for high energy midfoot fracture/dislocation during the 8-year study period. Eighteen polytrauma patients were selectively treated with a staged protocol. Radiographic assessment was utilized to determine if the fixator achieved gross skeletal alignment. Further, final alignment after definitive reconstruction and postoperative complications were analyzed. Results: The fixator improved both length and alignment of all high energy midfoot fracture/dislocations. Loss of acceptable reduction while in the temporary frame occurred in only 1 case. Final alignment after definitive reconstruction was anatomic in all cases. No cases of wound-related complication and/or deep infection occurred. Conclusion: Delayed reconstruction of high energy midfoot fracture/dislocation using interval external fixation should be an accepted care paradigm in selected polytrauma patients. Level of Evidence: Level III, retrospective comparative study.
Abstract settings for stabilization of nonlinear parabolic system with a Riccati-based strategy. Application to Navier-Stokes and Boussinesq equations with Neumann or Dirichlet control

Let $-A: \mathcal{D}(A)\to H$ be the generator of an analytic semigroup and $B : U \to [\mathcal{D}(A^*)]'$ a relatively bounded control operator such that $(A-\sigma,B)$ is stabilizable for some $\sigma>0$. In this paper, we consider the stabilization of the nonlinear system $y'+Ay+G(y,u)=Bu$ by means of a feedback or a dynamical control $u$. The control is obtained from the solution to a Riccati equation which is related to a low-gain optimal quadratic minimization problem. We provide a general abstract framework to define exponentially stable solutions which is based on the contruction of Lyapunov functions. We apply such a theory to stabilize, around an unstable stationary solution, the 2D or 3D Navier-Stokes equations with a Neumann control and the 2D or 3D Boussinesq equations with a Dirichlet control.
Physical-Based Analytical Model of Amorphous InGaZnO TFTs Including Deep, Tail, and Free States

Amorphous InGaZnO (a-IGZO) is a candidate material for thin-film transistors (TFTs) owing to its large electron mobility and good uniformity over large area. a-IGZO TFTs drain current models are essential for further pushing both a-IGZO TFTs technology and circuit design. In this paper, we propose a simple physical-based and analytical model of the drain current of a-IGZO TFTs. The model is valid in both non degenerate and degenerate conduction and it accounts for deep interface states, tail localized states, and free delocalized band states. The model is validated with the measurements of both coplanar and staggered a-IGZO TFTs. It provides key physical and material parameters of the transistor and, owing to its class $C^{\infty }$ formulation, it can be straightforwardly implemented in circuit simulators.
Cytotoxicity Testing of Multipurpose Contact Lens Solutions Using Monolayer and Stratified Cultures of Human Corneal Epithelial Cells

Objective: To investigate in vitro cytotoxicity of five marketed multipurpose contact lens solutions (MPS) on the morphology, viability, and barrier function of monolayer and stratified human corneal-limbal epithelial cells. Methods: Cells were exposed to MPS for 10, 20, or 60 minutes. In monolayer cultures, effects of the MPS on cell morphology were observed using Hoffman modulation contrast microscopy. Cell proliferation after exposure to MPS was evaluated and cytotoxicity of the MPS was determined using a live/dead cell assay and flow cytometry. In stratified cultures, multilayer corneal epithelial constructs were established on membrane inserts. Effects of the MPS on the morphology and barrier function of stratified cultures were determined using microscopy, a fluorescein permeability test, and measurement of trans-epithelial resistance. Results: In monolayer cultures, none of the MPS damaged cells during a 10-min exposure. All of the MPS had varying time-dependent adverse effects on cell morphology, viability, and proliferation during 20- and 60-min exposures. In stratified cultures, none of the MPS had an adverse effect on the structure or barrier function of stratified cultures. Conclusions: Monolayer cultures are highly sensitive to damage by MPS. In contrast, because stratified human corneal-limbal epithelial cultures are resistant to adverse effects of MPS, it is suggested that models that simulate the stratified structure of the corneal epithelium should be used for in vitro toxicologic testing. Caution should be used when interpreting such studies, because in vitro tests may not be predictive of clinical responses to contact lens products that are known to be safe when used as directed.
Comparison of Steroid and Botulinum Toxin Type A Monotherapy with Combination Therapy for Treating Human Hypertrophic Scars in an Animal Model

Background: The authors evaluated the efficacy of a combined regimen of botulinum toxin type A (Botox) and a steroid (triamcinolone acetonide) for treating hypertrophic scars in comparison with the treatment with each drug alone. Methods: Twenty excised human hypertrophic scar fragments obtained from surgically treated burn patients were divided into four groups: negative control (group A), triamcinolone alone (group B), Botox alone (group C), and a combination of triamcinolone and Botox (group D). These specimens were implanted into the backs of nude mice after intralesional injection from each group and were observed for 4 weeks. In total, 12 mice and 48 scars were studied. After 4 weeks, the hypertrophic scars were removed from the backs. The authors compared the scar weights, decorin staining, and the Cell Counting Kit-8 assay to evaluate treatment efficacy. Results: Significant differences in scar weight reduction were observed among the four groups (group A, 10 percent; group B, 17 percent; group C, 23 percent; and group D, 30 percent; p < 0.05). Treatment groups (groups B, C, and D) showed strong decorin staining. Significant differences in reduction of fibroblast proliferation were observed among the four groups (group A, 0.58; group B, 0.44; group C, 0.21; and group D, 0.08; p < 0.05). Botox or triamcinolone intralesional monotherapy showed significant therapeutic efficacy compared with the control group. The combined therapy further exhibited a significant therapeutic effect compared with monotherapy. Conclusion: This study indicates the potential of Botox and triamcinolone when combined for intralesional therapy in treating hypertrophic scars.
Assessing quality management in China with MBNQA criteria

This study reports a recent survey of the current state of quality management implementation and practices in China with reference to the Malcolm Baldrige National Quality Award (MBNQA) criteria. Comparisons are made between firms in three different stages of the development of a quality system: firms that focus on inspection, statistical quality control, and total quality management. The results support the common wisdom that firms practising total quality management have superior performance in leadership, strategic planning, customer and market focus, information and analysis, human resource focus, process management, and business results. The survey results also indicate that most Chinese firms still lack a full understanding of strategic quality management although a higher percentage of them claim that they are total quality management companies. To further the quality movement in China, quality managers and professionals should take a leading role in promoting contemporary, strategic quality management concepts and practices.
Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats

Background and purpose: Diabetes mellitus (DM) causes multiple dysfunctions including circulatory disorders such as cardiomyopathy, angiopathy, atherosclerosis and arterial hypertension. Rho kinase (ROCK) and protein kinase C (PKC) regulate vascular smooth muscle (VSM) Ca2+ sensitivity, thus enhancing VSM contraction, and up‐regulation of both enzymes in DM is well known. We postulated that in DM, Ca2+ sensitization occurs in diabetic arteries due to increased ROCK and/or PKC activity.