Miracle-dz/UniFAR-FTUs huggingface dataset:
Understanding Tor Usage with Privacy-Preserving Measurement

The Tor anonymity network is difficult to measure because, if not done carefully, measurements could risk the privacy (and potentially the safety) of the network's users. Recent work has proposed the use of differential privacy and secure aggregation techniques to safely measure Tor, and preliminary proof-of-concept prototype tools have been developed in order to demonstrate the utility of these techniques. In this work, we significantly enhance two such tools---PrivCount and Private Set-Union Cardinality---in order to support the safe exploration of new types of Tor usage behavior that have never before been measured. Using the enhanced tools, we conduct a detailed measurement study of Tor covering three major aspects of Tor usage: how many users connect to Tor and from where do they connect, with which destinations do users most frequently communicate, and how many onion services exist and how are they used. Our findings include that Tor has ~8 million daily users, a factor of four more than previously believed. We also find that ~40% of the sites accessed over Tor have a torproject.org domain name, ~10% of the sites have an amazon.com domain name, and ~80% of the sites have a domain name that is included in the Alexa top 1 million sites list. Finally, we find that ~90% of lookups for onion addresses are invalid, and more than 90% of attempted connections to onion services fail.
Underwater endoscopic mucosal resection of serrated adenomas

OBJECTIVES: Serrated polyps, which are considered to be precursors of colorectal carcinoma, include hyperplastic polyps, sessile serrated adenomas and traditional serrated adenomas. With the exception of hyperplastic polyps, all of these lesions must be removed. This study sought to examine whether underwater endoscopic mucosal resection is a safe and effective technique for treating serrated polyps. METHODS: Cases in which patients were submitted for underwater endoscopic mucosal resection and histologically diagnosed with sessile serrated adenoma were prospectively registered. RESULTS: The median patient age was 54.5 years (range, 48 to 72 years), and the patients included 4 men (28.5%) and 10 women (71.5%). One lesion (6.2%), 10 lesions (62.5%), 1 lesion (6.2%), 3 lesions (18.8%) and 1 lesion (6.2%) were found in the cecum, the ascending colon, the hepatic flexure, the transverse colon and the descending colon, respectively. The median lesion size was 20 mm (range, 10 to 35 mm). Eight lesions (50%) were removed en bloc, and the remaining eight lesions (50%) were removed using a piecemeal technique. None of the cases were complicated by perforation or delayed bleeding. CONCLUSION: Underwater resection could be a feasible, safe and effective alternative for the resection of sessile serrated adenomas.
Self Attention Grid for Person Re-Identification

In this paper, we present an attention mechanism scheme to improve person re-identification task. Inspired by biology, we propose Self Attention Grid (SAG) to discover the most informative parts from a high-resolution image using its internal representation. In particular, given an input image, the proposed model is fed with two copies of the same image and consists of two branches. The upper branch processes the high-resolution image and learns high dimensional feature representation while the lower branch processes the low-resolution image and learn a filtering attention grid. We apply a max filter operation to non-overlapping sub-regions on the high feature representation before element-wise multiplied with the output of the second branch. The feature maps of the second branch are subsequently weighted to reflect the importance of each patch of the grid using a softmax operation. Our attention module helps the network learn the most discriminative visual features of multiple image regions and is specifically optimized to attend feature representation at different levels. Extensive experiments on three large-scale datasets show that our self-attention mechanism significantly improves the baseline model and outperforms various state-of-art models by a large margin.
Cancer worries and uptake of breast, cervical, and colorectal cancer screening: A population-based survey in England

Objective Some degree of general worry about cancer may facilitate screening participation, but specific worries about the potential consequences (e.g. treatment, death) may act as deterrents. No studies have examined these associations in the same sample. We assessed associations between general versus specific cancer worries and cancer screening participation. Methods In 2016, a population-based cross-sectional survey of adults living in England was carried out. This paper reports analyses of a subsample (n = 1694). Measures included (i) frequency of general cancer worry, (ii) specific worries about the emotional and physical consequences of a cancer diagnosis, and (iii) specific worries about the social consequences of a cancer diagnosis. Logistic regression analyses examined their association with self-reported screening uptake among participants eligible for cervical (n = 671), breast (n = 323), and colorectal (n = 368) cancer screening. Results Frequency of general cancer worry was not associated with screening participation. Specific worry about the emotional and physical consequences increased the odds of participants reporting regular uptake of colorectal screening (OR 1.41, 95% CI 1.04–1.90). Specific worry about the social consequences of diagnosis was negatively associated with regular attendance for cervical and breast screening in unadjusted analyses only. In adjusted models, the associations were no longer statistically significant for cervical (OR 0.82, 95% CI 0.65–1.03) or breast (OR 0.69, 95% CI 0.45–1.04) screening. Conclusions Specific worries about cancer may be differentially associated with participation across screening programmes. Further research is needed, as interventions to optimise informed participation may be improved if the specific worries associated with low participation in each programme are understood.
Co-Activation, Estimated Anterior and Posterior Cruciate Ligament Forces, and Motor Unit Activation Strategies during the Time Course of Fatigue

This study aimed to combine co-activation as well as anterior and posterior cruciate ligament force estimations with the motor unit activation strategies employed by the primary muscles that are involved in the movement at the knee joint. Fourteen male subject performed 25 maximal concentric isokinetic leg extension muscle actions at 120 s−1. Electromyographic and mechanomyographic signals from the vastus lateralis and bicep femoris, as well as force, were used to measure co-activation, and estimated anterior and posterior ligament forces during the time course of fatigue. There were decreases in quadriceps force and increases in hamstring force during the 25 leg extensions. The posterior cruciate ligament force was greater than the anterior cruciate ligament force during each leg extension. Both the posterior and anterior cruciate ligament forces decreased during the 25 leg extensions. Each muscle indicated unique neuromuscular responses, which may explain the decreases in quadriceps force and increases in the hamstring force. The combination of anterior and posterior cruciate ligament force estimation and motor unit activation strategies helped to provide a better understanding of the fatigue-related mechanism that was utilized to avoid injury and increase or maintain joint stability during the time course of fatigue.
Information behaviour of architecture students in creative design projects

Purpose The purpose of this paper is to report on an exploratory study of third-year architecture students’ information behaviour. It focusses on information activities, personal experience, resource usage, preferences in working individually or collaboratively, preferences for information resources inspiring creativity and physical spaces to be creative. Design/methodology/approach It was a mixed methods study with a strongly qualitative component and limited descriptive quantitative data. Data were collected in October 2016 at a South African university using individual self-administered questionnaires and semi-structured individual interviews; 19 out of 60 (response rate 32 per cent) third-year architecture students doing a design project participated. Findings Creativity is important in architecture projects, as is information resources in stimulating creativity. Students preferred to work individually during their design projects; at times collaboration was needed for idea generation. Information activities included: information gathering, encountering, use and sharing. A range of theoretical, technical, artistic and practical skills and knowledge must be integrated to produce creative outcomes, in addition, to information searching and information usage. Factual information is also required. Students can benefit from a supportive information rich creative space (physical or virtual). Research limitations/implications The study was conducted at only one institution with a small number of participants. Although generalisation of findings is not possible, issues for further research can be noted. Practical implications Designers of physical and virtual creative spaces must take into account different facets of information behaviour and the information resources and services required during creative information-seeking activities. Originality/value Although there is literature on information behaviour and creativity, the authors could not find any that explores architecture students’ information behaviour in academic spaces of creativity.
Extending museum exhibits by embedded media content for an embodied interaction experience

This paper presents the results of an interdisciplinary applied research project about the application potential of ubiquitous computing concepts and technologies for knowledge transfer and exhibition design in museums. By interweaving mediated information directly into the context of exhibits and by transferring knowledge through discovery-based embodied interaction, we intend to overcome problems of distraction and social isolation, normally caused by handheld devices and graphical user interfaces. Applying scenario-based prototyping with a distributed hardware system allowed us to evaluate three case studies at three renowned Swiss museums. During the development and the evaluations, we followed five design principles that led to insights relevant for museums, design practitioners, the HCI community and technology developers. We concluded that the approach generates surprising experiences that have to be balanced with the exhibits and are very useful for explaining complex processes and functions, but cannot be implemented as an exclusive exhibition concept.
Sensoring a Generative System to Create User-Controlled Melodies

The automatic generation of music is an emergent field of research that has attracted the attention of countless researchers. As a result, there is a broad spectrum of state of the art research in this field. Many systems have been designed to facilitate collaboration between humans and machines in the generation of valuable music. This research proposes an intelligent system that generates melodies under the supervision of a user, who guides the process through a mechanical device. The mechanical device is able to capture the movements of the user and translate them into a melody. The system is based on a Case-Based Reasoning (CBR) architecture, enabling it to learn from previous compositions and to improve its performance over time. The user uses a device that allows them to adapt the composition to their preferences by adjusting the pace of a melody to a specific context or generating more serious or acute notes. Additionally, the device can automatically resist some of the user’s movements, this way the user learns how they can create a good melody. Several experiments were conducted to analyze the quality of the system and the melodies it generates. According to the users’ validation, the proposed system can generate music that follows a concrete style. Most of them also believed that the partial control of the device was essential for the quality of the generated music.
PDFi: participatory design fiction with vulnerable users

Traditional user-centred design processes frequently marginalize vulnerable users. Their perspectives are thus not well represented in discussions of the future of the medicines and technologies on which they rely. We present PDFi, a method that responds to this issue in the context of Urinary Tract Infections (UTIs). PDFi was developed through a collaboration with a medical device development company. The method marries Participatory Design (PD) strategies with Design Fictions (DFi) to personally ground, inspire and reveal values and imaginaries of vulnerable individuals who rely on medical technologies for their health and wellbeing. By more fully including these vulnerable users in shaping their medical technology futures, PDFi gives voice to those most impacted by such futures; it elicits emotions, discussion and debate, and powerfully reshapes current approaches to user-centred design.
JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia

ABSTRACT Sequencing data from large cohorts of T-cell acute lymphoblastic leukemia patients identified a significant association between the presence of JAK3 mutations and ectopic HOXA9 expression. Mouse models using a constitutive or novel inducible retroviral expression vector to express the JAK3(M511I) mutant and HOXA9 led to the development of an aggressive leukemia in vivo, with shorter latency than JAK3(M511I) or HOXA9 alone. This was primarily due to the co-binding of STAT5 and HOXA9 to the same genomic loci leading to increased oncogenic JAK-STAT signaling.
Gender and age distribution of motorcycle crashes in Spain

Abstract This study analysed motorcycle crashes in Spain. Ninety-nine thousand three hundred and four motorcycle crash reports filed in the years 2006–2011 were extracted from the Directorate General of Traffic database of crashes with victims. These data were analysed in terms of gender, age groups, trip purpose, type of crash, speed violation, day of the week, harm caused, use of helmet and psychophysical conditions of the driver to study the characteristics of motorcycle crashes in Spain and to assess the differences between male and female motorcycle drivers in these crashes. Significant differences were found in all the variables considered in the study, which implies gender differences in the profile of the injured motorcycle driver. The severity of motorcycle crashes suffered by male drivers is higher than that of women. These results corroborate the need to develop measures differentiated by gender, based on their profile.
Cataract surgery in diabetes mellitus: A systematic review

India is considered the diabetes capital of the world, and a significant proportion of patients undergoing cataract surgery are diabetic. Considering this, we reviewed the principles and guidelines of managing cataract in patients with diabetes. The preoperative, intraoperative, and postoperative factors are of paramount importance in the management of diabetic cataract patients. Particularly, the early recognition and treatment of diabetic retinopathy or maculopathy before cataract surgery influence the final visual outcome and play a major role in perioperative decision-making. Better understanding of various factors responsible for favorable outcome of cataract surgery in diabetic patients may guide us in better overalll management of these patients and optimizing the results.
The History of Bancroftian Lymphatic Filariasis in Australasia and Oceania: Is There a Threat of Re-Occurrence in Mainland Australia?

Lymphatic filariasis (LF) infects an estimated 120 million people worldwide, with a further 856 million considered at risk of infection and requiring preventative chemotherapy. The majority of LF infections are caused by Wuchereria bancrofti, named in honour of the Australian physician Joseph Bancroft, with the remainder due to Brugia malayi and B. timori. Infection with LF through the bite of an infected mosquito, can lead to the development of the condition known as elephantiasis, where swelling due to oedema leads to loss of function in the affected area and thickening of the skin, ‘like an elephant’. LF has previously been endemic in Australia, although currently, no autochthonous cases occur there. Human immigration to Australia from LF-endemic countries, including those close to Australia, and the presence of susceptible mosquitoes that can act as suitable vectors, heighten the possibility of the reintroduction of LF into this country. In this review, we examine the history of LF in Australia and Oceania and weigh up the potential risk of its re-occurrence on mainland Australia.
Laboratory-Assessed Markers of Cardiometabolic Health and Associations with GIS-Based Measures of Active-Living Environments

Active-living-friendly environments have been linked to physical activity, but their relationships with specific markers of cardiometabolic health remain unclear. We estimated the associations between active-living environments and markers of cardiometabolic health, and explored the potential mediating role of physical activity in these associations. We used data collected on 2809 middle-aged adults who participated in the Canadian Health Measures Survey (2007–2009; 41.5 years, SD = 15.1). Environments were assessed using an index that combined GIS-derived measures of street connectivity, land use mix, and population density. Body mass index (BMI), systolic blood pressure (SBP), hemoglobin A1c, and cholesterol were assessed in a laboratory setting. Daily step counts and moderate-to-vigorous intensity physical activity (MVPA) were assessed for seven days using accelerometers. Associations were estimated using robust multivariable linear regressions adjusted for sociodemographic factors that were assessed via questionnaire. BMI was 0.79 kg/m2 lower (95% confidence interval (CI) −1.31, −0.27) and SBP was 1.65 mmHg lower (95% CI −3.10, −0.20) in participants living in the most active-living-friendly environments compared to the least, independent of daily step counts or MVPA. A 35.4 min/week difference in MPVA (95% CI 24.2, 46.6) was observed between residents of neighborhoods in the highest compared to the lowest active-living-environment quartiles. Cycling to work rates were also the highest in participants living in the highest living-environment quartiles (e.g., Q4 vs. Q1: 10.4% vs. 4.9%). Although active-living environments are associated with lower BMI and SBP, and higher MVPA and cycling rates, neither daily step counts nor MVPA appear to account for environment–BMI/SBP relationships. This suggests that other factors not assessed in this study (e.g., food environment or unmeasured features of the social environment) may explain this relationship.
A Study of Strain-Driven Nucleation and Extension of Deformed Grain: Phase Field Crystal and Continuum Modeling

The phase-field-crystal (PFC) method is used to investigate migration of grain boundary dislocation and dynamic of strain-driven nucleation and growth of deformed grain in two dimensions. The simulated results show that the deformed grain nucleates through forming a gap with higher strain energy between the two sub-grain boundaries (SGB) which is split from grain boundary (GB) under applied biaxial strain, and results in the formation of high-density ensembles of cooperative dislocation movement (CDM) that is capable of plastic flow localization (deformed band), which is related to the change of the crystal lattice orientation due to instability of the orientation. The deformed grain stores the strain energy through collective climbing of the dislocation, as well as changing the orientation of the original grain. The deformed grain growth (DGG) is such that the higher strain energy region extends to the lower strain energy region, and its area increase is proportional to the time square. The rule of the time square of the DGG can also be deduced by establishing the dynamic equation of the dislocation of the strain-driven SGB. The copper metal is taken as an example of the calculation, and the obtained result is a good agreement with that of the experiment.
Epidural Analgesia and Neonatal Morbidity: A Retrospective Cohort Study

(1) Background: Epidural analgesia (EA), at the present time, is one of the most effective methods to reduce labor pain. In recent years its use has increased, being used between 20–70% of all deliveries; (2) Methods: Historical cohort on a total of 2947 deliveries during the years 2012–2016 at the “Mancha-Centro Hospital” of Alcázar de San Juan. The main outcome variables were four neonatal morbidity (NM) criteria: umbilical artery pH of <7.10, Apgar score at 5 min < 7, need for advanced resuscitation and composite morbidity. We used the multivariate analysis to control confounding bias. (3) Results: No statistical relationship between EA and the second stage of labor duration with none of the four criteria of NM used (p > 0.005). However, the type of delivery was associated with three criteria (pH, resuscitation, and composite morbidity). The instrumental delivery presented an OR of pH < 7.10 of 2.68 95% CI [1.15, 6.27], an OR of advanced resuscitation of 2.44 95% CI [1.17, 5.08] and OR of composite morbidity of 2.86 95% CI [1.59, 5.12]; (4) Conclusions: The EA and the second stage of labor duration are not related to the NM. While the instrumental delivery doubles the risk of NM compared to the normal vaginal delivery.
Fine structure of the tracheoles of the lantern of a photurid firefly

The lantern tracheoles of the firefly, Photuris, are unusual in that their walls are reinforced by cuticular bars. The tracheoles are stiff and resist collapse under conditions which flatten more typical tracheoles. This reinforcement and the structural resemblance of the tracheal end cell to cells considered to be active in moving ions and fluid is taken as evidence suggesting that the flash may be turned on and off by control of the oxygen supply and that said control may involve some sort of osmotic mechanism.
Endogenous Omega (n)-3 Fatty Acids in Fat-1 Mice Attenuated Depression-Like Behavior, Imbalance between Microglial M1 and M2 Phenotypes, and Dysfunction of Neurotrophins Induced by Lipopolysaccharide Administration

n-3 polyunsaturated fatty acids (PUFAs) have been reported to improve depression. However, PUFA purities, caloric content, and ratios in different diets may affect the results. By using Fat-1 mice which convert n-6 to n-3 PUFAs in the brain, this study further evaluated anti-depressant mechanisms of n-3 PUFAs in a lipopolysaccharide (LPS)-induced model. Adult male Fat-1 and wild-type (WT) mice were fed soybean oil diet for 8 weeks. Depression-like behaviors were measured 24 h after saline or LPS central administration. In WT littermates, LPS reduced sucrose intake, but increased immobility in forced-swimming and tail suspension tests. Microglial M1 phenotype CD11b expression and concentrations of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-17 were elevated, while M2 phenotype-related IL-4, IL-10, and transforming growth factor (TGF)-β1 were decreased. LPS also reduced the expression of brain-derived neurotrophic factor (BDNF) and tyrosine receptor kinase B (Trk B), while increasing glial fibrillary acidic protein expression and pro-BDNF, p75, NO, and iNOS levels. In Fat-1 mice, LPS-induced behavioral changes were attenuated, which were associated with decreased pro-inflammatory cytokines and reversed changes in p75, NO, iNOS, and BDNF. Gas chromatography assay confirmed increased n-3 PUFA levels and n-3/n-6 ratios in the brains of Fat-1 mice. In conclusion, endogenous n-3 PUFAs may improve LPS-induced depression-like behavior through balancing M1 and M2-phenotypes and normalizing BDNF function.