Miracle-dz/UniFAR-FTUs huggingface dataset:
Legitimacy and sincerity as leveraging factors in social sponsorship: an experimental investigation

Abstract The research presented in this manuscript examines how social sponsorship can be made more commercially effective. To this end, the effects of two leveraging factors are explored by means of an experiment: the extent to which the social sponsorship is seen by consumers as legitimate, and that to which the sponsor is perceived as sincere. The results show that these two factors have a positive and statistically significant impact on consumers’ intentions to purchase the sponsor’s products. In addition, they show that the sponsor’s perceived sincerity increases when the sponsorship is combined with philanthropic investments, either in sequence (i.e. philanthropy followed by sponsorship) or simultaneously, and that the legitimacy of a sponsorship is enhanced when the cause and its sponsor are congruent. These results are discussed in the context of the literature on social sponsorship, and managerial implications for firms that contemplate using social sponsorship as a marketing communication strategy are derived.
Assessing the Impact of Degree Day Base Temperatures on The Developmentof an Energy Index to Measure Energy Reduction

Refurbishment projects must be monitored before and after technology or behavior changes implementations to be able to assess their effectiveness and to drive conclusions on their applicability. An Energy Index approach has been previously developed and at its foundation, is the implication of base temperature selection on Degree Day for assessing energy reduction. The base temperature used to calculate Degree Days in the UK is 15.5 degrees. The aim of this study was to assess the impact of Degree Day base temperatures on the development of an Energy Index by means of correlation between energy consumption and Degree Days. The methodology was based on a low budget energy management strategy, in which the following information was collected: meter readings, internal temperature and outdoor conditions by means of degree-days. The methodology was employed in thirteen flats, with a control group of six flats having electric storage heaters and a further seven flats retrofitted with heat pumps. The flats were retrofitted with heat pumps; meter readings were collected around monthly intervals, while internal temperature was collected at 20 minutes intervals. Energy consumption was correlated to Degree Days based on 15.5 degrees and then compared to the correlation when the base temperature for Degree Days matches the internal flat temperature. The results show that by matching the base temperature to internal flat temperature, the average correlation improves from 0.55 to 0.76 and the average standard deviation improves from 0.36 to 0.19, meaning that the spread of results is reduced and a better evaluation of refurbishment technology or behavior changes can be achieved. The control group, with electric heater storages, experiences the greater correlation and standard deviation improvements. Matching the Degree Day base temperature to the internal temperature allows a more realistic accountability for the energy consumption to assess refurbishments by the Energy Index.
The effect of central and peripheral administration of acetylcholine and epinephrine on respiration.

The experiments were conducted in dogs anesthetized with Na-pentobarbital i.v. tidal volume (VT) and respiratory frequency (f min-1) were recorded. The central effects of acetylcholine (Ach) and epinephrine on respiration were investigated after injections of these substances directly into the cerebrospinal fluid by atlanto-occipital punction. The peripheral effects of Ach and epinephrine on respiration were studied after i.v. injections. Both central and peripheral administration of epinephrine caused significant increase in f min-1 and VT. After vagotomy the effects of centrally and peripherally administered epinephrine on f min-1 were abolished. The effect of central injection of epinephrine on VT persisted after vagotomy. The increase in VT in response to peripheral epinephrine administration was abolished by vagotomy. Both central and peripheral injection of Ach increased f min-1. In VT an initial decrease was followed by an increase. The initial decrease in VT was abolished by atropine. After vagotomy the effects of central and peripheral administration of Ach on f min-1 were abolished. The effects of central injection of Ach on VT persisted after vagotomy. Vagotomy abolished the effects of peripheral administration of Ach on VT.
Using Early Clinical Experiences to Integrate Quality‐improvement Learning into Medical Education

Health care providers are delivering care in an increasingly complex environment; this requires that providers develop new competencies to better understand their work and to design changes that can help them succeed. Recognizing these new educational requirements, Dartmouth Medical School created a model two-pronged program for teaching quality improvement to its medical students. The goal of the program is to provide students with an active learning experience as well as an education in the theory and application of continuous quality improvement. The program includes two educational experiences: one curriculum is for all medical students and the other is for selected, highly motivated students. The first curriculum is incorporated in Dartmouth's required “On Doctoring” course, in which students spend time with community-based physician preceptors. The quality-improvement curriculum is designed around an improvement project developed at the students' preceptor sites. The second curriculum for students with a special interest in quality improvement is offered as an elective summer program between the first and second years of medical school. Working in groups of two, students identify an area for improvement within a preceptor's practice, assist the practice in articulating an improvement plan, help implement that plan, and write up their experiences. The authors describe the two curricula, factors associated with their successful implementation, and lessons learned.
Incidence, risk factors, and mortality associated with acute respiratory distress syndrome in combat casualty care

BACKGROUND The overall incidence and mortality of acute respiratory distress syndrome (ARDS) in civilian trauma settings have decreased over the past four decades; however, the epidemiology and impact of ARDS on modern combat casualty care are unknown. We sought to determine the incidence, risk factors, resource utilization, and mortality associated with ARDS in current combat casualty care. METHODS This was a retrospective review of mechanically ventilated US combat casualties within the Department of Defense Trauma Registry (formerly the Joint Theater Trauma Registry) during Operation Iraqi Freedom/Enduring Freedom (October 2001 to August 2008) for ARDS development, resource utilization, and mortality. RESULTS Of 18,329 US Department of Defense Trauma Registry encounters, 4,679 (25.5%) required mechanical ventilation; ARDS was identified in 156 encounters (3.3%). On multivariate logistic regression, ARDS was independently associated with female sex (odds ratio [OR], 2.62; 95% confidence interval [CI], 1.21–5.71; p = 0.02), higher military-specific Injury Severity Score (Mil ISS) (OR, 4.18; 95% CI, 2.61–6.71; p < 0.001 for Mil ISS ≥25 vs. <15), hypotension (admission systolic blood pressure <90 vs. ≥90 mm Hg; OR, 1.76; 95% CI, 1.07–2.88; p = 0.03), and tachycardia (admission heart rate ≥90 vs. <90 beats per minute; OR, 1.53; 95% CI, 1.06–2.22; p = 0.02). Explosion injury was not associated with increased risk of ARDS. Critical care resource utilization was significantly higher in ARDS patients as was all-cause hospital mortality (ARDS vs. no ARDS, 12.8% vs. 5.9%; p = 0.002). After adjustment for age, sex, injury severity, injury mechanism, Mil ISS, hypotension, tachycardia, and admission Glasgow Coma Scale score, ARDS remained an independent risk factor for death (OR, 1.99; 95% CI, 1.12–3.52; p = 0.02). CONCLUSIONS In this large cohort of modern combat casualties, ARDS risk factors included female sex, higher injury severity, hypotension, and tachycardia, but not explosion injury. Patients with ARDS also required more medical resources and were at greater risk of death compared with patients without ARDS. Thus, ARDS remains a significant complication in current combat casualty care. LEVEL OF EVIDENCE Prognostic/epidemiologic study, level III.
R. J. Chambers on Securities and Obscurities: Making a Case for the Reform of the Law of Company Accounts in the 1970s

This study examines the contribution of Raymond J. Chambers to the British inflation accounting debate in the early‐to‐mid 1970s, from the perspective of the reception of his book, Securities and Obscurities: A Case for Reform of the Law of Company Accounts, published in 1973. To structure the empirical narrative, drawing on previously unpublished documents from the R. J. Chambers Archives, we employ Czarniawska and Joerges’ ( ) notion of the ‘travel of ideas’, and Mumford’s ( ) observation of the existence of ‘inflation accounting debate cycles’. The result is a narrative that traces the environmental and material circumstances that led to Chambers’ book having a lesser impact on the British inflation debate than one would expect based on the international exposure of his ideas, his influence at the time, and the empirical rigour of his proposal. The purpose of this exercise is to assess how contextual factors, such as the choice of publisher, use of promotional material, and distribution methods, can be as (or more) important than the substance of the proposed ideas, arguments, and solutions. [ABSTRACT FROM AUTHOR]
Identification of Eubacteria Isolated from Leaf Cavities of Four Species of the N-Fixing Azolla Fern as Arthrobacter Conn and Dimmick

The nutritional and physiological characteristics of 15 isolates from four species of the Azolla fern were determined. Although some minor variation existed in levels of urease activity, ability to utilize xylose, and formation of N2 gas from NO3, all 15 isolates were rather similar and believed to represent a single species. These eubacteria exhibited aminopeptidase activity and became viscous when treated with KOH, similar to gram-negative organisms; however, the absence of lipopolysaccharide and 2-keto-3-deoxyoctonate in cell walls indicated that they are truly gram-positive organisms. They are unusual because peptidoglycan could not be detected during most of their growth cycle. The presence of lysine as the major diamino acid in cell wall hydrolysates, the inability to hydrolyze cellulose, and the distinctive developmental pattern with rods and “V” forms present during log phase, becoming progressively shorter until cocci dominated during stationary and death phases, indicated that these organisms belong to the genus Arthrobacter Conn and Dimmick. With the exception of the inability to hydrolyze gelatin, their characteristics are consistent with those of the type species, Arthrobacter globiformis Conn and Dimmick.
Hypertension Impairs Cerebral Blood Flow in a Mouse Model for Alzheimer's Disease.

AIMS Hypertension, a risk factor for Alzheimer's disease (AD), is a treatable condition, which offers possibilities for prevention of AD. Elevated angiotensin II (AngII) is an important cause of essential hypertension. AngII has deleterious effects on endothelial function and cerebral blood flow (CBF), which may contribute to AD. AngII blocking agents can thus provide potential candidates to reduce AD risk factors in hypertensive patients. METHODS We studied the effect of 2 months induced hypertension (AngII-infusion via osmotic micropumps) on systolic blood pressure (SBP) and CBF in 10 months-old wild-type (WT) C57bl/6j and AβPPswe/PS1ΔE9 (AβPP/PS1) mice, and treatment with two different antihypertensives, 1) eprosartan mesylate (EM, 0.35mg/kg) or 2) hydrochlorotiazide (HCT, 7.5mg/kg), after 1 month of induced-hypertension. SBP was monitored twice each month via tail cuff plethysmography. CBF was measured with MR by flow-sensitive alternating inversion recovery. RESULTS Chronic AngII-infusion induced an increase in SBP in both AβPP/PS1 and WT mice accompanied by a decrease in hippocampal and thalamic CBF only in the AβPP/PS1 mice. An additional difference between the AβPP/PS1 mice and WT mice was that SBP was much higher in AβPP/PS1 mice in both hypertensive and normotensive conditions. Moreover, both antihypertensives were less effective in reducing AngII-induced hypertension to normal levels in AβPP/PS1 mice, while being effective in WT mice. CONCLUSIONS It can be concluded that AngII-induced elevated SBP results in impaired CBF and a decreased response to blood pressure lowering treatment in a transgenic model of AD. Our findings suggest a relation between midlife hypertension and decreased CBF in an AD mouse model, similar to the relation which has been found in AD patients. This translational mouse model could be used to investigate possible prevention and treatment strategies for AD.
DO LABOR MARKETS PROVIDE ENOUGH SHORT‐HOUR JOBS? AN ANALYSIS OF WORK HOURS AND WORK INCENTIVES

This paper examines the role that work incentives play in the determination of work hours. Following previous research by Lang (1989), we use a conventional efficiency wage model to analyze how firms respond to worker preferences regarding wage-hours packages. We find that when workers are homogeneous, the role of worker preferences in determining work hours is similar to the simple neoclassical model of labor supply. For instance, if worker preferences shift in favor of shorter hours, firms will respond by offering jobs entailing shorter hours. When workers have heterogeneous preferences, however, employers will want to use a worker's hours preferences as a signal for the responsiveness of the worker to the work incentives used by the firm, and workers in turn may not reveal their hours preferences. Our key finding in this instance is that the labor market equilibrium may be characterized by a sub-optimal number of short-hour jobs. This shortage of short-hour jobs is likely to be found in high wage labor markets.
Effects of treated and untreated bran in dough dynamic rheology

Grains of the wheat variety Tajan were milled into straight-run flour and bran. Proximate analysis, farinograph experiments and rheological characteristics were conducted. Two types of bran (hydrothermal treated and untreated) at three levels (0%, 5%, 10%) were added to the parent flour. Proximate analysis and farinograph experiments of these flours were conducted. The effects of adding treated and untreated bran in linear (strain=0.1%) and non-linear limits (strain=1%, 5%, 10%) have been determined by dynamic oscillatory tests. Results show that, in the linear limit, the G′ value for the untreated bran sample is very close to parent flour while the G′ value of treated bran flour is lower than that of parent flour. The same changes occur in G″ values. In the non-linear limit, the G′ values for both treated and untreated bran samples were higher than parent flour while the G″ value for untreated bran samples had no significant difference from the parent flour. Tge loss tangent for untreated bran flour in the non-linear limit was higher than that of the parent flour, while for treated bran flour it is lower than parent flour. It can be concluded that untreated bran weakens the gluten matrix. On the other hand, adding treated bran, to some extent, strengthens the protein matrix.
Drug abuse treatment as AIDS prevention.

OBJECTIVE As the acquired immunodeficiency syndrome (AIDS) epidemic among drug users enters its third decade in the United States, it is important to consider the role playing by substance abuse treatment in the prevention of human immunodeficiency virus (HIV) infection. METHODS The authors review the research literature, examining findings from studies with behavioral and serologic measures on the association among treatment participation, HIV risk reduction, and HIV infection. RESULTS Numerous studies have now documented that significantly lower rates of drug use and related risk behaviors are practiced by injecting drug users (IDUs) who are in treatment. Importantly, these behavioral differences, based primarily on self-report, are consistent with studies that have examined HIV seroprevalence and seroincidence among drug users. CONCLUSION The underlying mechanism of action suggested by the collective findings of the available literature is rather simple-- individuals who enter and remain in treatment reduce their drug use, when leads to fewer instances of drug-related risk behavior. This lower rate of exposure results in fewer infections with HIV. The protective effects of treatment, however, can only be achieved when programs are accessible and responsive to the changing needs of drug users. Future research needs to be directed at developing a better understanding of the factors that enhance treatment entry and retention.
Biomarker changes associated with the development of resistance to aromatase inhibitors (AIs) in estrogen receptor-positive breast cancer.

BACKGROUND The purpose of this study was to identify any differences in key biomarkers associated with estrogen action between biopsies taken at diagnosis and at recurrence or progression during treatment with an aromatase inhibitor (AI). PATIENTS AND METHODS Patients were retrospectively identified from a clinical database as having relapsed or progressed during AI treatment. Immunohistochemistry was carried out against estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2), insulin-like growth factor type-1 receptor (IGF1R), insulin receptor substrate-1 (IRS-1), stathmin, phosphatase and tensin homolog and Ki67. RESULTS Fifty-five pairs of samples were identified with ER- and/or PgR-positive diseases. Four (7%) patients were ER-negative at progression. Overall, PgR levels were lower in the recurrence sample, but 35% of cases remained positive. IGF1R levels decreased significantly. There were no substantial changes in HER2, IRS-1 or stathmin levels to indicate a role in resistance. Higher Ki67 levels at resistance indicate more proliferative disease. CONCLUSIONS The phenotype of AI-recurrent lesions shows high between-tumour heterogeneity. There is evidence of an increase in Ki67, a reduction in IGF1R and a loss of ER expression in some individuals and some activation of growth factor signalling pathways that may explain resistance in individuals and merit treatment targeted to those pathways. Biopsy at recurrence will be necessary to identify the relevant target for individuals.
Chemokine and cytokine expression in murine intestinal epithelium following Nippostrongylus brasiliensis infection

Infection of mice with the nematode parasite Nippostrongylus brasiliensis results in a well characterized intestinal mastocytosis with intraepithelial migration of mucosal mast cells (MMC). The molecules mediating this response are unknown. We examined expression of several putative mast cell chemoattractants in intestinal epithelium following N. brasiliensis infection. Expression of the chemokines monocyte chemoattractant protein‐1 (MCP‐1), macrophage inflammatory protein‐1α(MIP‐1α), RANTES (regulated on activation normal T‐cell expressed and secreted), fractalkine, and thymocyte expressed chemokine (TECK); and the cytokines stem cell factor (SCF) and transforming growth factor β1 (TGFβ1), was constitutive and no alteration was detected following infection. MCP‐1 expression was also constitutive but at much lower levels and increased expression was detected on days 7 and 14 postinfection. Expression of MCP‐1 in whole jejunum was at much higher levels than in epithelium. Constitutive expression of MCP‐1, MIP‐1α and TGFβ1 was also detected in cultured bone marrow‐derived homologues of MMC. In an intestinal epithelial cell line (CMT‐93), there was constitutive expression of SCF, TGFα1, fractalkine and MCP‐1. The results show that, in vivo, epithelium is a potentially important source of mast cell chemoattractants.
Overcoming Barriers to Transnational Organizing Through Identity Work: Finnish–Estonian Trade Union Cooperation

This article analyses a project by Finnish and Estonian unions to adopt ‘organizing model’ strategies through establishing the transnational ‘Baltic Organising Academy’. Initially aimed at Estonian workplaces, successful campaigns inspired Finnish unions to copy the model in Finland. This cooperation was originally motivated by labour market interdependence between the two countries, and the failure of past social-partnership oriented union strategies in Estonia. The willingness of Finnish and Estonian unions to commit resources to transnational cooperation around an ‘organizing model’ marks a dramatic departure from the unions’ previous strategies. This change was accomplished by transnational activists who have developed and raised support for the adoption of an ‘organizing model’ in the face of structural challenges and ideological opposition by some union officials. The project’s transnational organizing exemplifies one possible solution to union weakness in Eastern Europe, and underlines the importance of ‘identity work’ in building transnational trade union coalitions around organizing.
Endotoxin induces a dose‐dependent myocardial cross‐tolerance to ischemia‐reperfusion injury

Objective: To test whether or not endotoxin induces a dose‐dependent reduction of myocardial contractile dysfunction after a standardized period of myocardial ischemia and reperfusion and whether nitric oxide is involved in this form of myocardial protection. Design: Prospective, randomized, controlled animal study. Setting: University research laboratory. Subjects: Twenty‐five male Sprague‐Dawley rats. Interventions: After anesthesia, the left carotid artery was cannulated under sterile conditions and animals were allowed to recover from surgery for 12 hrs. Sterile saline or increasing doses (2.5, 5, or 10 mg/kg body weight) of endotoxin (Escherichia coli 026:B6; Sigma, Mississauga, Ontario, Canada) were given intravenously (1 mL over 5 mins). In some rats, diaspirin‐crosslinked hemoglobin (200 mg/kg) was infused 6 hrs and 60 min before endotoxin infusion (10 mg/kg). Hearts were rapidly excised for retrograde perfusion through the ascending aorta (Langendorff apparatus) 6 hrs later. After baseline data collection, hearts were subjected to global ischemia (30 mins, 37°C [98.6°F]), followed by 30 mins of reperfusion. Measurements and Main Results: Physiologic variables were recorded 6 hrs after saline and endotoxin infusion. Baseline myocardial systolic contractility and diastolic compliance were assessed, respectively, by left ventricular developed pressure (LVDP) and left ventricular (LV) volume‐preload relationships. After 30 min of reperfusion, LVDP recovery and left ventricular end‐diastolic pressure were measured. Endotoxin induced LV systolic contractile depression, irrespective of the dose of endotoxin administered. LV diastolic dysfunction varied between different doses of endotoxin administered. On reperfusion, endotoxin produced a dose‐dependent improvement of postischemic LVDP recovery: 30 ± 6% in sham, 78 ± 9% in 2.5 mg/kg, 93 ± 8% in 5 mg/kg, and 107 ± 10% in 10 mg/kg endotoxin heart. In rats treated with 10 mg/kg endotoxin, diaspirin‐crosslinked hemoglobin pretreatment abrogated endotoxin‐induced postischemic LVDP recovery improvement (105 ± 10% vs. 43 ± 7%, p = .01). Conclusion: Sublethal doses of endotoxin induce in a dose‐dependent manner a delayed form of myocardial protection against ischemia. Although free‐cell hemoglobin solution abrogates this endotoxin‐induced cross‐tolerance, we propose that possible mechanisms involved in this form of myocardial protection include nitric oxide pathway activation.