Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimal Portfolio Choice over the Life-Cycle with Flexible Work, Endogenous Retirement, and Lifetime Payouts

This paper derives optimal lifecycle asset allocations for consumers who select work hours and retirement ages given uncertain labor income and investment returns. These shocks shape retirement and asset allocation patterns in complex ways: negative labor market shocks and high stock returns influence the young to work less and buy more annuities, and later, to retire early. This flexibility enhances welfare; our model also fits several important empirical stylized facts including the two peaks in retirement rates, the hump-shaped pattern of work hours, the sizeable discontinuity in consumption at retirement, and low annuity take-ups of older households. Copyright 2011, Oxford University Press.
Krüppel-Like Factors in Metabolic Homeostasis and Cardiometabolic Disease

Members of the Krüppel-like factor (KLF) family of transcription factors, which are characterized by the presence of three conserved Cys2/His2 zinc-fingers in their C-terminal domains, control a wide variety of biological processes. In particular, recent studies have revealed that KLFs play diverse and essential roles in the control of metabolism at the cellular, tissue and systemic levels. In both liver and skeletal muscle, KLFs control glucose, lipid and amino acid metabolism so as to coordinate systemic metabolism in the steady state and in the face of metabolic stresses, such as fasting. The functions of KLFs within metabolic tissues are also important contributors to the responses to injury and inflammation within those tissues. KLFs also control the function of immune cells, such as macrophages, which are involved in the inflammatory processes underlying both cardiovascular and metabolic diseases. This review focuses mainly on the physiological and pathological functions of KLFs in the liver and skeletal muscle. The involvement of KLFs in inflammation in these tissues is also summarized. We then discuss the implications of KLFs' control of metabolism and inflammation in cardiometabolic diseases.
Fas ligand promotes an inducible TLR‐dependent model of cutaneous lupus‐like inflammation

&NA; Toll‐like receptors TLR7 and TLR9 are both implicated in the activation of autoreactive B cells and other cell types associated with systemic lupus erythematosus (SLE) pathogenesis. However, Tlr9‐/‐ autoimmune‐prone strains paradoxically develop more severe disease. We have now leveraged the negative regulatory role of TLR9 to develop an inducible rapid‐onset murine model of systemic autoimmunity that depends on T cell detection of a membrane‐bound OVA fusion protein expressed by MHC class II+ cells, expression of TLR7, expression of the type I IFN receptor, and loss of expression of TLR9. These mice are distinguished by a high frequency of OVA‐specific Tbet+, IFN‐&ggr;+, and FasL‐expressing Th1 cells as well as autoantibody‐producing B cells. Unexpectedly, contrary to what occurs in most models of SLE, they also developed skin lesions that are very similar to those of human cutaneous lupus erythematosus (CLE) as far as clinical appearance, histological changes, and gene expression. FasL was a key effector mechanism in the skin, as the transfer of FasL‐deficient DO11gld T cells completely failed to elicit overt skin lesions. FasL was also upregulated in human CLE biopsies. Overall, our model provides a relevant system for exploring the pathophysiology of CLE as well as the negative regulatory role of TLR9.
Assessment of animal hosts of pathogenic Leptospira in northern Tanzania

Leptospirosis is a zoonotic bacterial disease that affects more than one million people worldwide each year. Human infection is acquired through direct or indirect contact with the urine of an infected animal. A wide range of animals including rodents and livestock may shed Leptospira bacteria and act as a source of infection for people. In the Kilimanjaro Region of northern Tanzania, leptospirosis is an important cause of acute febrile illness, yet relatively little is known about animal hosts of Leptospira infection in this area. The roles of rodents and ruminant livestock in the epidemiology of leptospirosis were evaluated through two linked studies. A cross-sectional study of peri-domestic rodents performed in two districts with a high reported incidence of human leptospirosis found no evidence of Leptospira infection among rodent species trapped in and around randomly selected households. In contrast, pathogenic Leptospira infection was detected in 7.08% cattle (n = 452 [5.1–9.8%]), 1.20% goats (n = 167 [0.3–4.3%]) and 1.12% sheep (n = 89 [0.1–60.0%]) sampled in local slaughterhouses. Four Leptospira genotypes were detected in livestock. Two distinct clades of L. borgpetersenii were identified in cattle as well as a clade of novel secY sequences that showed only 95% identity to known Leptospira sequences. Identical L. kirschneri sequences were obtained from qPCR-positive kidney samples from cattle, sheep and goats. These results indicate that ruminant livestock are important hosts of Leptospira in northern Tanzania. Infected livestock may act as a source of Leptospira infection for people. Additional work is needed to understand the role of livestock in the maintenance and transmission of Leptospira infection in this region and to examine linkages between human and livestock infections.
The complexities of urban flood response: Flood frequency analyses for the Charlotte metropolitan region

We examine urban flood response through data‐driven analyses for a diverse sample of “small” watersheds (basin scale ranging from 7.0 to 111.1 km2) in the Charlotte Metropolitan region. These watersheds have experienced extensive urbanization and suburban development since the 1960s. The objective of this study is to develop a broad characterization of land surface and hydrometeorological controls of urban flood hydrology. Our analyses are based on peaks‐over‐threshold flood data developed from USGS streamflow observations and are motivated by problems of flood hazard characterization for urban regions. We examine flood‐producing rainfall using high‐resolution (1 km2 spatial resolution and 15 min time resolution), bias‐corrected radar rainfall fields that are developed through the Hydro‐NEXRAD system. The analyses focus on the 2001–2015 period. The results highlight the complexities of urban flood response. There are striking spatial heterogeneities in flood peak magnitudes, response times, and runoff ratios across the study region. These spatial heterogeneities are mainly linked to watershed scale, the distribution of impervious cover, and storm water management. Contrasting land surface properties also determine the mixture of flood‐generating mechanisms for a particular watershed. Warm‐season thunderstorm systems and tropical cyclones are main flood agents in Charlotte, with winter/spring storms playing a role in less‐urbanized watersheds. The mixture of flood agents exerts a strong impact on the upper tail of flood frequency distributions. Antecedent watershed wetness plays a minor role in urban flood response, compared with less‐urbanized watersheds. Implications for flood hazard characterization in urban watersheds and for advances in flood science are discussed.
Efficacies of Rhagoletis cerasi (Diptera: Tephritidae) Traps and Ammonium Lures for Western Cherry Fruit Fly

Abstract Western cherry fruit fly, Rhagoletis indifferens Curran (Diptera: Tephritidae), is a quarantine pest of cherries (Prunus spp.) in western North America that can be detected using sticky yellow rectangle traps. Recently, a related invasive fly from Europe and Asia, the European cherry fruit fly, Rhagoletis cerasi (L.) (Diptera: Tephritidae), was detected in eastern North America, prompting surveys for it in the West. Sticky crossed-panel yellow Rebell and cylindrical-type yellow PALz traps were developed for R. cerasi and are effective for monitoring it, raising the question of efficacies of three-dimensional versus rectangle traps against R. indifferens. Here, efficacies of the Yellow Sticky Strip (YSS) rectangle, thus far the best trap for R. indifferens, and Rebell and PALz traps with ammonium lures were determined for R. indifferens in Washington State. The Rebell and YSS traps caught similar numbers of R. indifferens and more than the PALz trap. Ammonium carbonate (AC) released more ammonia than ammonium acetate and attracted more R. indifferens to all three traps. The large surface area or shape of the Rebell trap was responsible for its high efficacy relative to the YSS. Results suggest that YSS and Rebell traps with AC would be equally useful for detecting R. indifferens, and that a crossed-sheet YSS trap could be even more efficacious than the YSS due to greater surface area. For R. cerasi detection surveys in Washington, the PALz trap would be preferred over the Rebell trap if they are equally efficacious against R. cerasi, as fewer R. indifferens would clutter traps.
The Influence of Selected Human Resource Management Practices on Employee Satisfaction in the Technical University of Kenya

Universities globally are affected by a number of human resource management practices in achieving employee job satisfaction. There has been need for universities to understand the role of human resource management practices in achieving organizations success by viewing employees as partners to an organization. By viewing employees as the organization's most valuable asset and treating them as internal customers, the organization will gain a competitive advantage and achieve its objectives. The purpose of the study was to determine the effects of selected human resource management practices on employee satisfaction in The Technical University of Kenya. The specific human resource management practices presupposed to have an effect on employee satisfaction as postulated in the study were training and development, and reward systems. The study adopted a case study research design, covering a stratified sample of 200 respondents drawn from a population of 2000 employees of The Technical University of Kenya. The data collected through questionnaires and interviews was analyzed using both descriptive and inferential statistics. Correlation and multiple regression analysis was undertaken to determine and explain the relationship between the variables. The study revealed a positive and significant relationship between the human resource management practices covered and employee job satisfaction; training and development (Pearson’s r=0.510, p<0.000), reward system (Pearson’s r=0.742, p<0.000. Regression test revealed that all the independent variables accounts for 63.3% of the employee job satisfaction. From the study findings, it is clear that training and development, and reward systems are key human resource management practices that influence employee job satisfaction. The study recommends that public universities should lay emphasis on various human resource management practices that are responsible for employee satisfaction. They should lay emphasis on employee training and development and adequate reward systems that are equitable and fair to all employee.
The Satisfaction With Life Scale Adapted for Children: Measurement Invariance Across Gender and Over Time

This paper examined measurement invariance (MI), both across gender and over time, of the Satisfaction With Life Scale adapted for Children (SWLS-C). Adapted from the adult SWLS, the SWLS-C is a self-report measure for children and adolescents to assess their life satisfaction. The sample comprised elementary school students in British Columbia, Canada (n = 4,026) who responded to the SWLS-C in Grade 4 (M(age) = 9.3, SD = 0.6; 48.9% girls) and approximately 3 years later in Grade 7. We examined MI regarding gender, time, and both gender and time (i.e., interactional invariance) using Clustered Repeated Measures Multi-Group Confirmatory Factor Analysis with a mean- and variance-adjusted weighted least squares (WLSMV) estimation. Residual invariance by gender was supported at Grades 4 and 7; scalar invariance was supported longitudinally for each gender and overall. In the “interactional” model, including gender and time, analyses indicated scalar MI, but not residual MI. Analyses of latent factor means indicated that SWLS-C scores significantly decreased for both girls and boys from Grade 4 to Grade 7. The decrease was more pronounced for girls, but gender differences at either age were not significant. The pattern of observed mean scores differed, as it indicated no significant decrease for boys’ SWLS-C scores, but significant gender differences at both time points. However, given the lack of residual invariance, comparisons of observed SWLS-C mean scores across gender and over time may be compromised. The different results for latent and observed mean SWLS-C scores highlight the importance of routinely conducting MI analyses for group comparisons.
Evidence of increased Hepatitis E virus exposure in Lao villagers with contact to ruminants

Although pigs are the main reservoir, ruminants have also been shown to be susceptible to hepatitis E virus (HEV). We investigated zoonotic transmission of HEV in rural settings of Lao People's Democratic Republic (Lao PDR) where humans are in close contacts with ruminants and where pigs are rare. Villagers with (n = 171, risk group) and without (n = 155, control group) cattle were recruited in seven villages in Vientiane Capital. Owners of pigs were excluded. Blood, as well as information on socio‐demographics, animal contact, dietary habits and awareness of zoonoses were collected to assess risk factors. Blood and rectal swabs were collected from cattle (n = 173) and other ruminants (27 goat, 5 buffaloes) to measure anti‐HEV antibody and virus prevalence. A similar anti‐HEV antibody seroprevalence was found in cattle (6.8%) and other ruminants (8%). HEV RNA was detected in none of the animal rectal swabs and human sera. Anti‐HEV IgG seroprevalence was higher in cattle farmers than in the control group (59.1% vs. 43.9%, p = 0.008) and increased significantly with age. Other risk factors included male gender, close contact with cattle and consumption of undercooked meat. We find that HEV is highly endemic in rural Laos and provide first evidence that HEV circulates in free‐roaming ruminants with open access to village water sources. Despite some awareness about hygiene, villagers are likely constantly exposed to zoonotic diseases by dietary and lifestyle habits. Cattle farmers had a higher risk of HEV infection than other villagers. Our study highlights the need to raise the awareness of the rural population about water‐ and food‐borne pathogens, and about the role of cattle as a possible source of infection. The knowledge gained on local risk factors and husbandry conditions should guide future awareness raising campaigns and promote appropriate hygienic measures including handwashing and the consumption of safe food and water.
Implementation of a Positive Technology Application in Patients With Eating Disorders: A Pilot Randomized Control Trial

Background: Positive psychological interventions (PPIs) have been suggested to produce benefits in patients with eating disorders (ED) by improving well-being, which might act as a buffer of the harmful effects caused by the disorder. Best Possible Self (BPS) is a PPI which consists of writing and envisioning a future where everything has turned out in the best possible way. In this regard, positive technology (PT) can be of considerable benefit as it allows to implement specific PPIs that have already shown efficacy. Objective: This study tested the preliminary efficacy of the BPS exercise implemented through a PT application and carried out for 1 month, in improving positive functioning measures, compared to a control condition, in patients with ED. Follow-up effects were also explored at 1 and 3 months later. Methods: This is a pilot randomized controlled trial, with two experimental conditions. Participants were 54 outpatients, who were receiving ongoing specialized treatment in ED services. 29 participants were randomly allocated to the BPS intervention and 25 to the control exercise. The sample was composed mostly by females and the mean age was 27 years. In the intervention group, participants had to write about their BPS. In the control group participants had to write about their daily activities. The exercise was conducted through the Book of Life, which is a PT application that allows users to add multimedia materials to the written content. Measures of future expectations, affect, dispositional optimism, hope and self-efficacy were assessed at different time frames. Results: Findings showed that all participants improved over time and there were no statistically significant differences between conditions on the specific measures. These effects were not influenced by prior levels of ED severity. Within-group effect sizes indicate a greater benefit for the participants in the BPS condition, compared to the control condition, on nearly all the measures. Conclusion: Results indicated that PT produced modest improvements in patients with EDs that are receiving current treatment for ED. More empirical attention is needed to explore the potential benefits of PPIs as supporting tools in the prevention and treatment of EDs. Trial registration: clinicaltrails.gov Identifier: NCT03003910, retrospectively registered December 27, 2016.
Clinical assessment of acute lateral ankle sprain injuries (ROAST): 2019 consensus statement and recommendations of the International Ankle Consortium

Lateral ankle sprain injury is the most common musculoskeletal injury incurred by individuals who participate in sports and recreational physical activities. Following initial injury, a high proportion of individuals develop long-term injury-associated symptoms and chronic ankle instability. The development of chronic ankle instability is consequent on the interaction of mechanical and sensorimotor insufficiencies/impairments that manifest following acute lateral ankle sprain injury. To reduce the propensity for developing chronic ankle instability, clinical assessments should evaluate whether patients in the acute phase following lateral ankle sprain injury exhibit any mechanical and/or sensorimotor impairments. This modified Delphi study was undertaken under the auspices of the executive committee of the International Ankle Consortium. The primary aim was to develop recommendations, based on expert (n=14) consensus, for structured clinical assessment of acute lateral ankle sprain injuries. After two modified Delphi rounds, consensus was achieved on the clinical assessment of acute lateral ankle sprain injuries. Consensus was reached on a minimum standard clinical diagnostic assessment. Key components of this clinical diagnostic assessment include: establishing the mechanism of injury, as well as the assessment of ankle joint bones and ligaments. Through consensus, the expert panel also developed the International Ankle Consortium Rehabilitation-Oriented ASsessmenT (ROAST). The International Ankle Consortium ROAST will help clinicians identify mechanical and/or sensorimotor impairments that are associated with chronic ankle instability. This consensus statement from the International Ankle Consortium aims to be a key resource for clinicians who regularly assess individuals with acute lateral ankle sprain injuries.
Which patients receive surgery in for-profit and non-profit hospitals in a universal health system? An explorative register-based study in Norway

Objectives To compare the socioeconomic status (SES) and case-mix among day surgical patients treated at private for-profit hospitals (PFPs) and non-profit hospitals (NPs) in Norway, and to explore whether the use of PFPs in a universal health system has compromised the principle of equal access regardless of SES. Design A retrospective, exploratory study comparing hospital types using the Norwegian Patient Register linked with socioeconomic data from Statistics Norway by using Norwegian citizens’ personal identification numbers. Setting The Norwegian healthcare system. Population All publicly financed patients in five Norwegian metropolitan areas having day surgery for meniscus (34 100 patients), carpal tunnel syndrome (15 010), benign breast hypertrophy (6297) or hallux valgus (2135) from 2009 to 2014. Primary outcome measure Having surgery at a PFP or NP. Results Across four unique procedures, the adjusted odds ratios (aORs) for using PFPs were generally lower for the lowest educational level (0.77–0.87) and the lowest income level (0.68–0.89), though aORs were not always significant. Likewise, comorbidity and previous hospitalisation had lower aORs (0.62–0.95; 0.44–0.97, respectively) for having surgery at PFPs across procedures, though again aORs were not always significant. No clear patterns emerged with respect to age, gender or higher levels of income and education. Conclusions The evidence from our study of four procedures suggests that equal access to PFPs compared with NPs for those patients at the lowest education and income levels may be compromised, though further investigations are needed to generalise these findings across more procedures and probe causal mechanisms and appropriate policy remedies. The finding that comorbidity and previous hospitalisation had lower odds of treatment at PFPs indicates that NPs play an essential role for more complex patients, but raises questions about patient preference and cream skimming.
(In)Secure Configuration Practices of WPA2 Enterprise Supplicants

WPA2 Enterprise is a fundamental technology for secure communication in enterprise wireless networks. A key requirement of this technology is that WiFi-enabled devices (i.e., supplicants) be correctly configured before connecting to the enterprise wireless network. Supplicants that are not configured correctly may fall prey of attacks aimed at stealing the network credentials very easily. Such credentials have an enormous value because they usually unlock access to all enterprise services. In this work we investigate whether users and technicians are aware of these important and widespread risks. We conducted two extensive analyses: a survey among approximately 1000 users about how they configured their WiFi devices for enterprise network access; and, a review of approximately 310 network configuration guides made available by enterprise network administrators. The results provide strong indications that the key requirement of WPA2 Enterprise is violated systematically and thus can no longer be considered realistic.