Miracle-dz/UniFAR-FTUs huggingface dataset:
Information Requisition for Computer-Supported Medical Care

One indispensable precondition for designing a functional software product for the modeling and execution of a computerized clinical practice guideline (CPG) is the comprehensive investigation of the different user groups involved and the issues they encounter. This led us to conduct a comprehensive literature study about the tasks involved in modeling a CPG into a formal representation as well as about the information needs of caregivers, i.e., physicians and nurses, and last but not least the information needs of patients. We have assessed and categorized the above mentioned information in order to create a reliable starting point for the development of a functional software tool.
Study on Prevalence of Vitamin D Deficiency Among Newborns And Their Mothers in Jharkhand

Background: Vitamin D deficiency is an important health problem in pregnant women and their infants. The present study evaluated serum 25-hydroxyvitamin D3 [25(OH)D3] concentrations in healthy term newborns and their mothers. Objective: To measure serum levels of 25(OH)D3, Parathormone, Inorganic Phosphate, Calcium, Albumin, and Alkaline Phosphatase in healthy term newborns and their mothers and to establish correlation between mother’s and their newborn’s vitamin D status. Material and method: Ninety-five healthy term newborns and their mothers were included in the cross sectional study between July 2014 and July 2015. Sampling was done by systematic random sampling. Maternal and cord blood samples were taken to measure levels of 25(OH)D3, Parathormone, Inorganic Phosphate, Calcium, Albumin, and Alkaline Phosphatase. Results and discussion: Mean maternal serum 25(OH)D3 was 16.2 ± 6.7 ng/mL, and cord blood 25(OH)D was 13.6 ± 6.7 ng/mL. Seventy-four mothers (77.9%) had hypovitaminosis-D. Seventy-nine newborns (83.1%) had hypovitaminosis D. There was a significant (r=0.8;P<0.001) correlation between maternal and cord blood vitamin D levels which indicates that risk factors for infant vitamin D deficiency includes maternal deficiency in vitamin D. Conclusion: A high prevalence of physiologically significant hypovitaminosis D among pregnant women and their newborns was observed. Vitamin D supplementation campaigns which should cover pregnant women and the newborn to prevent maternal and perinatal vitamin D deficiency should be implemented especially in risk areas.
Investigating the Physiological and Psychosocial Responses of Single- and Dual-Player Exergaming in Young Adults.

OBJECTIVE This study investigated the effect of acute exergaming on the physiological and psychosocial responses of young adults and the modulatory effect of a single- or dual-player game play situation. MATERIALS AND METHODS Thirty-six participants (19 male; 21.7 ± 3.8 years; 23.65 ± 3.17 kg/m2) each completed two 30-minute exergame sessions in a randomized order (single and dual player) while wearing an Actiheart® to estimate energy expenditure. Positive and negative affect, subjective vitality, and indices of intrinsic motivation were assessed directly after each gaming bout. RESULTS There was no significant difference in energy expenditure or psychosocial outcomes between conditions. Although males expended more energy than females in both single- (z = -2.124, P = 0.033) and dual-player situations (z = -2.679, P = 0.007), females reported significantly greater vitality (z = -2.219, P = 0.026) and effort/importance than males (z = -2.001, P = 0.045). Conversely, males reported a greater negative affect (z = -2.872, P = 0.004) and pressure/tension (z = -3.295, P = 0.001). A linear mixed effects model revealed that energy expenditure during exergaming was a significant predictor of interest and enjoyment (P = 0.001) and effort and importance (P = 0.001). This relationship between energy expenditure and psychosocial variables was not modulated by sex or order of gameplay (single or dual player first). CONCLUSION The present results suggest that females have a more positive psychosocial response to exergaming relative to males, highlighting exergames such as Wii™ boxing as a potential avenue for future interventions seeking to address the low physical activity levels that characterize the young adult population.
Performance on Paced Serial Addition Tasks Indicates an Associative Network for Calculation

Although paced serial addition (PSA) tasks are considered to be tests of general information-processing capacity, recent work suggests that performance on such tasks is influenced by arithmetic-specific variables. We designed two visual PSA experiments to determine whether the performance of normal adults would support predictions derived from the cognitive psychology of calculation. Experiment 1 showed that mixing familiar (Arabic numeral) and less familiar (Roman numeral) stimulus formats reduced scores below the averaged scores for pure Arabic and Roman lists. The Roman-Arabic order of addends was more difficult than the Arabic-Roman order. Experiment 2, which involved only Arabic numerals as addends, showed that performance could be impaired by constraining the trial-to-trial variability of sums. The results of both experiments confirm the importance of arithmetic-specific variables in PSA and provide support for an associative network model of calculation. In addition, the findings implicate interference from extraneous addends and responses as the performance-limiting factor.
The diagnostic characteristics of a group of patients with primary gastric lymphoma: macroscopic, histopathological and immunohistochemical aspects.

UNLABELLED Primary gastric lymphoma is defined as the malignant lymphoproliferative disease with initial symptoms located in the stomach, or tumor mass located in the stomach. This paper aims to present the macroscopic, histopathological and immunohistochemical aspects encountered in a group of patients with primary gastric lymphoma, diagnosed between 2005 and 2010 in the Hematology Clinic of Craiova and the Hematology Clinic of "Fundeni" Institute in Bucharest. MATERIALS AND METHODS This study was performed on a group of 65 patients diagnosed with primary gastric lymphoma. The positive diagnosis in primary gastric lymphoma is established by the histopathological and immunohistochemical analysis of gastric biopsies, taken during the upper gastrointestinal endoscopy, or of gastric resection samples. We used the monoclonal antibodies CD20, CD10, CD5, k light chain, PCNA (proliferating cell nuclear antigen) and Ki67. RESULTS The average age of the patients enrolled in the study was 52.55 years. The most common macroscopic feature encountered was the mixed ulcerative-vegetative one. We found two histological types, represented by diffuse large B-cell lymphoma (with or without MALT component), and marginal zone lymphoma (MALT type). Both the MALT type lymphoma and the diffuse large B-cell lymphoma revealed B-cell phenotype. CONCLUSIONS A correct diagnosis is very important in terms of therapeutic approach. The characteristics of the group of patients were: a higher number of the aggressive histological type; an excessive use of gastric resection; none of the cases was a T-lymphoproliferation.
Estrogen regulation of prodynorphin gene expression in the rat adenohypophysis: effect of the antiestrogen tamoxifen.

Prodynorphin (Prodyn)-derived peptides are synthesized in a subset of gonadotrope cells and released concomitantly with LH and FSH, and their levels in the rat adenohypophysis are influenced by the gonadal steroid environment. In several hormonal systems, factors that affect peptide levels may modulate the transcription of messenger RNA (mRNA) encoding for the target gene. Therefore, the present study was designed to investigate the effects of gonadal ablation and estrogen replacement on changes in steady state levels of anterior pituitary Prodyn mRNA and on the transcription rate in the adult female rat. The antiestrogen tamoxifen was employed for further exploring the relationships between estrogens and dynorphin (dyn)-related peptides. Adopting a solution hybridization-ribonuclease protection assay, steady state levels of Prodyn mRNA doubled in 2-week ovariectomized (OVX) rats, in parallel with a 3-fold increase in immunoreactive dyn-A-(1-17)-like material (irdyn-A). Estradiol (E2) replacement through sc SILASTIC implants for 1, 3, 7, and 14 days, which produces serum E2 levels between 25-35 pg/ml, restored in a time-dependent manner mRNA and peptide concentrations to values in sham-OVX rats. A significant decrease was observed after 3 days, and after 7 days, the effect was maximal. Tamoxifen (250 micrograms/kg.day, sc) administered simultaneously antagonized the action of E2 on Prodyn gene expression. Tamoxifen administered without E2 for 7 or 14 days significantly raised anterior pituitary levels of Prodyn mRNA and ir-dyn-A. To establish whether E2 and tamoxifen exert their effects on adenohypophyseal Prodyn mRNA by influencing the transcriptional activity of this gene, an in vitro transcriptional elongation assay was performed on nuclei from the anterior pituitary. The transcriptional rate of the Prodyn gene was significantly increased in 2-week OVX rats. Prodyn mRNA synthesis was suppressed in OVX rats exposed to E2, an effect antagonized by tamoxifen administered concomitantly. The antiestrogen administered alone for 14 days further elevated the transcriptional rate of Prodyn mRNA induced by gonadal ablation. In conclusion, E2 down-regulated the synthesis of Prodyn-derived peptides in adenohypophyseal cells. The antiestrogen tamoxifen antagonized the effect of E2 and, when chronically administered to OVX rats, further elevated the postcastrational rise in Prodyn gene expression.
Revising Working Models Across Time: Relationship Situations That Enhance Attachment Security

We propose the Attachment Security Enhancement Model (ASEM) to suggest how romantic relationships can promote chronic attachment security. One part of the ASEM examines partner responses that protect relationships from the erosive effects of immediate insecurity, but such responses may not necessarily address underlying insecurities in a person’s mental models. Therefore, a second part of the ASEM examines relationship situations that foster more secure mental models. Both parts may work in tandem. We posit that attachment anxiety should decline most in situations that foster greater personal confidence and more secure mental models of the self. In contrast, attachment avoidance should decline most in situations that involve positive dependence and foster more secure models of close others. The ASEM integrates research and theory, suggests novel directions for future research, and has practical implications, all of which center on the idea that adult attachment orientations are an emergent property of close relationships.
Seasonal variations of water and sediment quality parameters in endorheic reed pans on the Mpumalanga Highveld

The Mpumalanga Lakes District consists of approximately 320 pans, of which less than 3% are classified as reed pans. There is limited information available on reed pans and as a result they are at risk of various anthropogenic activities, for example mining and agriculture. Four reed pans were selected and assessed to determine seasonal trends of a variety of water and sediment quality parameters. The study took place over one seasonal cycle from 2008–2009; samples were collected seasonally to account for various hydrological extremes. Water samples were collected and their nutrient and chlorophyll a concentrations were determined, while various other water quality parameters were measured in situ. Sediment samples were analysed for physical and chemical properties, namely, grain size and organic carbon content. The seasonal changes in concentrations of As, Cr, Cu, Fe, Pb, Mn, Mo, Ni, Se, Sr, U and Zn were also analysed within the surface water and sediment. Increased nutrient concentrations within the water were evident during spring and summer at some of the sites, which influenced other water quality variables, e.g., dissolved oxygen and pH. Seasonal trends in metal concentrations were influenced by the prevailing environmental conditions (e.g., rainfall) experienced at the selected sites as well as physical and chemical properties (e.g., grain size and organic carbon content). This study showed distinct seasonal variability of water and sediment quality parameters in endorheic reed pans on the Mpumalanga Highveld. There is a need for further studies on all of the different types of pans in terms of their water and sediment quality. This type of information will allow for a sound and defensible scientific basis for the assessment of likely impacts (e.g., eutrophication), the evaluation of the significance of these impacts, and the design of remedial and preventative measures.
Pseudo‐anterior interosseous nerve syndrome

The anterior interosseous nerve syndrome (AINS) is well known. A case is presented that had electromyographic findings limited to the distri‐bution of the anterior interosseous nerve. A small area of sensory loss and slight asymmetry of amplitudes noted on median nerve conduction studies were inconsistent with an AIN syndrome. An antecubital level partial median nerve compromise primarily involving the bundles that form the anterior interosseous nerve was surgically noted. This case illustrates that localization of a peripheral nerve lesion must include consideration of the internal topography of peripheral nerves.
IL-12 Treatment of Endogenously Arising Murine Brain Tumors1

A number of recent studies have indicated that T cells can be stimulated to attack transplanted brain tumors in rodent models. As IL-12 has been shown to activate cytotoxic T cell responses, we tested the idea that it might stimulate a T cell response against endogenous brain tumors that arise in SV40 large T Ag transgenic mice (SV11). SV11 mice develop tumors of the choroid plexus, a specialization of the ependymal lining of the brain ventricles. They are a particularly relevant model of human disease, because they are immunocompetent but immunologically tolerant of the tumors. SV11 mice were treated with recombinant murine IL-12 for 10 days. Tumors grew more slowly than in control treated mice, and in some cases were reduced in size, as assessed by magnetic resonance imaging before and after treatment. At the end of treatment, tumors, but not brain parenchyma, exhibited extensive infiltration of activated CD8+ and CD4+ T cells. Tumors also showed a reduction in vascular density. Mice treated with IL-12 lived significantly longer than control mice. Tumors that progressed were nearly devoid of T cells, indicating that the T cell response was not sustained. In addition, some mice that had a substantial tumor burden at the beginning of treatment displayed evidence of immunosuppression, which might be related to TGF-β2 detected in tumors. We conclude that IL-12 treatment can initiate an anti-tumor response even against endogenously arising brain tumors, but factors that will allow a sustained and more effective anti-tumor response need to be determined.
Malnutrition and the Family: Deprivation in Kwashiorkor

The background to social and emotional deprivation is discussed and applied to a study of kwashiorkor in East African children. A group of 107 children with kwashiorkor was compared with 111 controls. Age, sex and tribe were all found to have significances of their own: fifty of each group were therefore matched for these three factors. Ten other factors were found to be significant in the background of children with kwashiorkor, all of which could be associated with social or emotional deprivation or both (see Table 14). It is concluded that, in childhood, sustained personal care and affection are essential to normal growth.
Case in point? A parasuicide patient’ s recollections of being nursed: A discourse analysis

Abstract This paper highlights the recollections of being nursed from the perspective of a patient (Gabby) admitted to a general medical ward after attempting suicide. A discourse analysis was used to discuss the way in which Gabby was nursed, enabling identification of the social structure which supports the nurse-patient relationship. This research evolved with the realisation that the point of view of parasuicide patients was primarily absent within nursing literature. Inattention within the literature was later replicated by Gabby’ s expressions of inadequate interaction between nurses and parasuicide patients.
Phosphate and Vitamin D Prevent Periodontitis in X-Linked Hypophosphatemia

X-linked hypophosphatemia (XLH) is a rare genetic skeletal disease where increased phosphate wasting in the kidney leads to hypophosphatemia and prevents normal mineralization of bone and dentin. Here, we examined the periodontal status of 34 adults with XLH and separated them according to the treatment they received for hypophosphatemia. We observed that periodontitis frequency and severity were increased in adults with XLH and that the severity varied according to the hypophosphatemia treatment. Patients who benefited from an early and continuous vitamin D and phosphate supplementation during their childhood presented less periodontal attachment loss than patients with late or incomplete supplementation. Continued hypophosphatemia treatment during adulthood further improved the periodontal health. Extracted teeth from patients with late or incomplete supplementation showed a strong acellular cementum hypoplasia when compared with age-matched healthy controls. These results show that XLH disturbs not only bone and dentin formation but also cementum and that the constitutional defect of the attachment apparatus is associated with attachment loss.
The Pathogenesis of Disciform Degeneration of the Macula.

In 1875 Pagenstecher gave a description of the macroscopic and microscopic appearance of a macular lesion observed in an eye after its removal for adherent leukoma and secondary glaucoma. His descriptions and illustrations of this lesion leave little doubt that the eye was affected with what is now known as disciform degeneration of the macula. His is the first case of this disease that we were able to find recorded in the literature. He designated the condition chorioidioretinitis in regione maculae luteae. The first employment of the term degeneratio maculae luteae disciformis was by Oeller in 1905. In 1926 Junius and Kuhnt adopted this term, substituting, however, Netzhautmitte for macula lutea, and definitely established the condition as a disease entity. Other terms to designate the disease, employed prior to the publication of their monograph, are indicated by the titles in the appended bibliography. The term favored by
Effect of Enzymes on the Interaction of Enteroviruses with Living HeLa Cells

Zajac, Ihor (Hahnemann Medical College, Philadelphia, Pa.), and Richard L. Crowell. Effect of enzymes on the interaction of enteroviruses with living HeLa cells. J. Bacteriol. 89:574–582. 1965. —Eight crude enzyme preparations and two crystalline enzymes were tested for ability to inactivate coxsackie group B and poliovirus receptors on living HeLa cells. Receptor-destroying enzyme, erepsin, lysozyme, collagenase, proteinase, and cobra venom did not alter attachment of coxsackie B3 or poliovirus T1 to cells, whereas elastase prevented attachment of both viruses tested. Treatment of live cells with pancreatin or chymotrypsin rendered cells unable to attach group B coxsackie viruses, whereas cells treated with trypsin failed to attach poliovirus T1. In addition, chymotrypsin was found to release coxsackie B3 and poliovirus T1 from cell surfaces, whereas trypsin was unable to dissociate virus-cell union. These results indicate that cellular receptors for polioviruses differ from those for group B coxsackie-viruses. The finding that 1% solutions of enzymes will inactivate differentially the enteroviral receptors of HeLa cells, without altering cell viability, provides a useful approach for study of enterovirus receptors of live host cells.
Distributed Circuit Modeling of Multilayer Capacitor Parameters Related to the Metal Film Layer

Linkage between the distributed-circuit capacitor model and multi-layer capacitor structures is demonstrated. Capacitor inductance leading to self-resonance in standard metallized polymer capacitors arises from lead and package inductance and can be represented by lumped inductance external to the capacitor modeling in this paper. Distributed internal capacitor inductance is negligible in metallized polymer capacitors for most applications and therefore is not considered in the analysis. Two different distributed-circuit topologies, both of which arise in practice-one by design and the other by degradation-are considered. One has the two connecting electrodes on opposite ends of the capacitor and the other has both input electrodes on the same end. The electrical performance of the two connection topologies is compared using numerical 10-stage lumped element modeling. Cross comparisons are made using diffusion equation modeling for the single-end connection topology. Strong correspondence between results from numerical lumped element distributed approximations and from diffusion equation analysis for the single-end connection is demonstrated up to 100MHz, this inferring similar accuracy for lumped element modeling of the double-end connected capacitor topology. The results show that the two connection topologies exhibit similar behavior up to at least the typical self resonance frequency of the capacitor, except for the cross-dielectric voltage and cross-width power dissipation profiles which are fundamentally different. Voltage drop across the metallic films is shown to be small in normal steady state operation. The contribution of the metallic film to the equivalent series resistance is shown to be constant with frequency up to a frequency where distributed - filtering becomes significant. Beyond this, both equivalent series resistance and capacitance fall with the square root of frequency for the single-end connected capacitor. Similarly, the dissipation factor initially rises in direct proportion to frequency and power dissipated in the metal film increases with the square of frequency. Progressive disconnection of distant metal film with frequency, due to filtering, is shown to be responsible for the changes in these relationships and the parameters of the capacitor.
Wheat Grain and Forage Yields are Affected by Planting and Harvest Dates in the Central Great Plains

Although grazing of winter wheat (Triticum aestivum L.) is a common practice in the southern Great Plains, little is known about the efficacy of wheat as a dual-purpose crop in the Nebraska Panhandle. The objective of this study was to evaluate the effects of establishment and harvest times on forage and grain production of wheat cultivars adapted to the region, Six cultivars were planted at four dates (very early, recommended early, recommended late, and very late) in each of 3 yr. Forage samples were taken from a previously nonharvested area late in the fall, at jointing, and at the boot stage. Grain yield at maturity was measured from each forage harvest treatment and from a full-season unharvested control. In 2 of 3 yr. grain yield was reduced an average of 25% compared with the full-season check when plants were harvested for forage at the joint stage. No grain was produced when forage was removed at the boot stage. Forage removal during the fall averaged 1300 kg ha -1 dry matter and resulted in insignificant losses in grain yield. While most of the fall growth was too low to the ground for clipping, it could provide high-value supplemental grazing on account of the high crude protein (310 g kg 1 ) and in vitro organic matter digestibility (800 g kg -1 ) levels. Spring grazing in this region is limited to the time prior to jointing if market conditions favor grain production.