Miracle-dz/UniFAR-FTUs huggingface dataset:
Insulin-Like Growth Factor II mRNA Binding Protein 1 Associates with Gag Protein of Human Immunodeficiency Virus Type 1, and Its Overexpression Affects Virus Assembly

ABSTRACT The assembly of human immunodeficiency virus type 1 (HIV-1) particles is driven by viral Gag protein. This function of Gag not only benefits from its self-multimerization property but also depends on its interaction with a number of cellular factors such as TSG101 and ALIX/AIP1 that promote virus budding and release from cell surfaces. However, interaction with Gag also allows some cellular factors such as APOBEC3G and Trim5α to access viral replication machinery and block viral replication. In this study, we report a new HIV-1 Gag-binding factor named insulin-like growth factor II mRNA binding protein 1 (IMP1). Gag-IMP1 interaction requires the second zinc finger of the nucleocapsid (NC) domain of Gag and the KH3 and KH4 domains of IMP1. A fourfold reduction of HIV-1 infectivity was seen with overexpression of the wild-type IMP1 and its mutant that is able to interact with Gag but not with overexpression of IMP1 mutants exhibiting Gag-binding deficiency. The decreased viral infectivity was further shown as a result of diminished viral RNA packaging, abrogated Gag processing on the cellular membranes, and impeded maturation of virus particles. Together, these results demonstrate that IMP1 interacts with HIV-1 Gag protein and is able to block the formation of infectious HIV-1 particles.
Decreasing Non-Value-Added Nursing Time Transporting Stable Patients From the Emergency Department

In the emergency department (ED), one non-value-added task is transporting stable patients to telemetry units. This process improvement intervention introduces a decision tree to determine which patients are stable enough to be safely transported nonmonitored, thus more efficiently using valuable nursing time. A decision tree was utilized to determine which patients would be transported nonmonitored. A data collection instrument was completed at the time of each nonmonitored transport of a patient, and data were collected over a 4-month period. A total of 280 patients met the criteria to be transported nonmonitored from the ED to the inpatient unit during the data collection period, saving an average of 20.7 hr per month. With appropriate use of the decision tree, clinical staff successfully determined the need for monitored transport of patients admitted to non-intensive care unit telemetry units from the ED. There were no adverse patient events.
IN VITRO ANTIFUNGAL ACTIVITY OF LEAF EXTRACTS OF AZADIRACHTA INDICA

Objective: The study was to evaluate the antidermatophytic activity of the ethanol, ethyl acetate and hexane extract of Neem ( Azadirachta indica) leaves against dermatophytes isolated from patients with dermatophytosis. Methods: Clinical samples from 200 patients were subjected to (KOH) examination and culture isolation. Causative agents were identified macroscopically and microscopically. The minimum inhibitory concentration (MIC) by broth dilution method and minimum fungicidal concentration (MFC) for the solvent extract of the leaves of the plant Azadirachta indica against the isolated dermatophytes was determined. Results: Dermatophytes were isolated in 126/200 specimens.Of the three solvents used, ethanolic and ethyl acetate extract was found to be more active inhibiting 100% of the isolates at a concentration of 125µg/ml. Conclusion: In conclusion ethanolic and ethyl acetate leaf extracts of Azadirachta indica plant can be used to treat infections with dermatophytic fungi.
Real-Time Recognition of Calling Pattern and Behaviour of Mobile Phone Users through Anomaly Detection and Dynamically-Evolving Clustering

In the competitive telecommunications market, the information that the mobile telecom operators can obtain by regularly analysing their massive stored call logs, is of great interest. Although the data that can be extracted nowadays from mobile phones have been enriched with much information, the data solely from the call logs can give us vital information about the customers. This information is usually related with the calling behaviour of their customers and it can be used to manage them. However, the analysis of these data is normally very complex because of the vast data stream to analyse. Thus, efficient data mining techniques need to be used for this purpose. In this paper, a novel approach to analyse call detail records (CDR) is proposed, with the main goal to extract and cluster different calling patterns or behaviours, and to detect outliers. The main novelty of this approach is that it works in real-time using an evolving and recursive framework.
Cross-Cultural Variations in Predictors of Life Satisfaction: Perspectives from Needs and Values

The authors tested for cross-cultural difference in predictors of life satisfaction. In Study 1 (39 nations, N = 54,446), they found that financial satisfaction was more strongly associated with life satisfaction in poorer nations, whereas home life satisfaction was more strongly related to life satisfaction in wealthy nations. In Study 2 (39 nations, N = 6,782), the authors found that satisfaction with esteem needs (e.g., the self and freedom) predicted global life satisfaction more strongly among people in individualist nations than people in collectivist nations. The present investigation provides support for the needs and values-as-moderators model of subjective well-being at the cultural level. The need for theories that account for culture-specific as well as universal predictors of life satisfaction will be discussed.
Pre‐emptive renal transplantation from living donors in Australia: Effect on allograft and patient survival

Aim: Pre‐emptive renal transplantation has become the preferred first‐line therapy for patients with end‐stage kidney failure. This study examines the outcome of allograft and patient survival in pre‐emptive transplantation compared with non‐pre‐emptive transplantation from living donors in Australia and New Zealand.
Long-Term Persistence of Humoral Immunity After Hepatitis A Vaccination in HIV-Infected Adults

s of the XVIII International AIDS Conference, July 18–23, 2010; Vienna, Austria. 7. Cruciani M, Mengoli C, Serpelloni G, et al. Serologic response to hepatitis B vaccine with high dose and increasing number of injections in HIV infected adult patients. Vaccine. 2009;27:
The Effects of Auditory Structural Complexity on Attitudes, Attention, Arousal, and Memory

Twenty-five participants listened to 8 radio messages—half of which were greater in auditory structural complexity. Physiological measures were taken during message presentation, and self-report measures after each. Results show that increased auditory structural complexity led to higher self-reported and physiological arousal, better attitudes toward the messages overall and toward their nonclaim components. There were no differences in attitudes toward the claims made in the messages at each level of structural complexity. Structurally complex messages were also freely recalled more often than simple messages. The prediction that messages high in auditory structural complexity would result in greater self-reported attention levels received only moderate support. Furthermore, high levels of auditory structural complexity resulted in unexpectedly higher cardiac activity compared to messages low in structural complexity.
New-Onset Diabetes After Kidney Transplantation and Pretransplant Hypomagnesemia

Aim: Hypomagnesemia is a frequent finding in kidney transplant patients and plays a causal role in insulin resistance and diabetes. The aim of this study was to investigate whether the pretransplant magnesium (Mg) level is a risk factor for the development of new-onset diabetes after kidney transplantation (NODAT) and the presence of relationship between pretransplant hypomagnesemia and the development period of NODAT. Methods: Four hundred and nineteen nondiabetic renal transplant recipients were evaluated retrospectively. The patients were divided into NODAT and non-NODAT groups. The time of diagnosis of patients with NODAT was divided into 0 to 3, 3 to 6, 6 to 12 months, and after 12 months. Patients’ characteristics and pretransplant Mg levels in NODAT were compared with non-NODAT, and it was investigated whether pretransplant hypomagnesemia was a risk factor for the development of NODAT. Results: Totally 70 (16.6%) patients (36 female [F], mean age 51.7 ± 8.2 years) were diagnosed with NODAT. Three hundred and forty-nine patients (115 F, mean age 43.2 ± 12.5 years) did not have NODAT. Pretransplant mean Mg level was 1.97 ± 0.40 mg/dL in patients with NODAT, while it was 2.5 ± 0.45 mg/dL in non-NODAT patients (P < .001). Serum Mg level was found to be similar in subgroups according to the development period of NODAT (P = .07). When patients were stratified according to quartiles of Mg level, the frequency of NODAT was significantly higher in patients in the lower quartile (Mg < 2.1 mg/dL; P < .001). Older age, high body mass index, and low pretransplant serum Mg levels were established as risk factors for developing NODAT. According to the quartile of Mg level, the risk of developing NODAT was highest in the lowest quartile. Conclusion: Pretransplant hypomagnesemia is an independent risk factor of NODAT. Therefore, it is necessary to closely monitor the Mg levels in the posttransplant period.
Antibiotic resistance properties of uropathogenic Escherichia coli isolated from pregnant women with history of recurrent urinary tract infections

Purpose: To investigate the antibiotic resistance pattern of uropathogenic Escherichia coli (UPEC) strains isolated from pregnant women with history of recurrent urinary tract infections (RUTIs) and healthy pregnant women. Methods: A total of 485 high vaginal swab specimens were collected from pregnant women with history of RUTIs and healthy ones. Samples were cultured and those that were E. coli positive were analyzed by polymerase chain reaction (PCR) and disk diffusion tests. Results: Twenty eight out of 445 (6.29 %) samples were positive for E. coli . Prevalence of E. coli in pregnant women with history of RUTIs and healthy ones were 9 and 4.08 %, respectively. Women older than 40 years were the most commonly infected. UPEC strains showed the highest levels of resistance against ampicillin (96.42 %), tetracycline (85.71 %), amikacin (71.42 %), ciprofloxacin (67.85 %) and gentamycin (58.71 %). Conclusion: RUTIs and pregnancy in old age are two important risk factors for transmission of UPEC strains from the urinary tract into the vagina. Primary treatment of infected pregnant women with imipenem, mezlocillin and nitrofurantoin would be effective for the prevention and management of vaginal infections in pregnant women. Keywords: Uropathogenic Escherichia coli , Recurrent urinary tract infections, Antibiotic resistance, Pregnant women
Planar Compact LTE/WWAN Monopole Antenna for Tablet Computer Application

A novel design of a planar multiband monopole antenna with dual parasitic shorted strips for LTE/WWAN operation in the tablet computer is proposed. The obtained impedance bandwidth across the operating bands can reach about 255/980 MHz for the LTE/WWAN bands, respectively. Only with the antenna size of 45<formula formulatype="inline"><tex Notation="TeX">$\,\times\,$</tex> </formula>15<formula formulatype="inline"><tex Notation="TeX">$\,\times\,$</tex> </formula>0.8 mm<formula formulatype="inline"><tex Notation="TeX">$^{3}$</tex> </formula>, the proposed planar antenna has the compact operation with more than 25% antenna size reduction. The measured peak gains and antenna efficiencies are about 2.5/3.6 dBi and 85/84% for the LTE/WWAN bands, respectively.
Measure algebras and functions of bounded variation on idempotent semigroups

Our main result establishes an isomorphism between all functions on an idempotent semigroup S with identity, under the usual addition and multiplication, and all finitely additive measures on a certain Boolean algebra of subsets of S, under the usual addition and a convolution type multiplication. Notions of a function of bounded variation on S and its variation norm are defined in such a way that the above isomorphism, restricted to the functions of bounded variation, is an isometry onto the set of all bounded measures. Our notion of a function of bounded variation is equivalent to the classical notion in case S is the unit interval and the "product" of two numbers in S is their maximum.
HEMATOLOGY AND SERUM CHEMISTRY COMPARISONS BETWEEN FREE-RANGING AND REHABILITATED HARBOR SEAL (PHOCA VITULINA RICHARDSI) PUPS

The objectives of this study were to compare the hematology and serum chemistry values between free-ranging and stranded harbor seal (Phoca vitulina richardsi) pups and to ascertain how blood values of stranded pups changed during the rehabilitation process. Coincident with these comparisons, reference values were obtained for free-ranging pups. Stranded harbor seal pups (n=28) recovered from areas between Pebble Beach and Moss Landing, California (USA) were admitted to The Marine Mammal Center, Sausalito, from March to May 1995, 1996, and 1998. Blood samples were collected from harbor seal pups before and after rehabilitation. As a control group, wild harbor seal pups were captured at Pebble Beach and Elkhorn Slough (n=42) during the 1995, 1996, and 1998 pupping seasons. Mean eosinophil and calcium values of wild pups were significantly greater than those of newly admitted pups, whereas mean bands, aspartate aminotransferase, alanine aminotransferase, total bilirubin, and chloride values were significantly lower (P≤0.05). Mean neutrophil, band, lymphocyte, eosinophil, basophil, calcium, phosphorus, blood urea nitrogen, potassium, total protein, and globulin values of rehabilitated pups increased significantly after 2–3 mo in captivity, whereas, mean red blood cell, hemoglobin, hematocrit, cholesterol, and total bilirubin values decreased significantly (P≤0.05).
20.6 A 28GHz efficient linear power amplifier for 5G phased arrays in 28nm bulk CMOS

Rapidly growing demand for broadband-cellular-data traffic is driving fifth-generation (5G) wireless standardization towards the deployment of gigabit-per-second mm-Wave technology by 2020. Paving the road to 5G, 200m coverage in non-line-of-sight (NLOS) urban cells was demonstrated using practical antenna arrays at 28GHz [1], and the FCC recently issued a notice of inquiry into the provision of mobile services above 24GHz. Battery life and thermal limitations make power efficiency critical in the envisioned user-equipment (UE) phased-array transceivers, particularly for power amplifiers (PAs), which operate at 8-to-10dB power back-off (PBO) to transmit broadband, high-peak-to-average power-ratio (PAPR) signals with high fidelity. Higher yields and lower costs for integrated phased arrays make CMOS the preferred choice over other more-power-efficient technologies, e.g. GaAs. Furthermore, calibrating an integrated array of PAs, e.g. by using digital pre-distortion, is prohibitively complex for high-volume manufacturing. Thus, maximizing PAE of inherently linear CMOS PA circuits at PBO is a major challenge for future 5G UE radios.
Age of onset as a discriminator between alcoholic subtypes in a treatment-seeking outpatient population.

Subtyping alcoholics may provide a more accurate guide as to the course and character of the disease. Classifications of different ages of onset of problem drinking have so far resulted in categorical inconsistencies. In the past, hospital-based alcoholics have over-represented those most severely ill, and comprehensive evaluations of psychopathology for discriminating between alcoholic subtypes have been infrequent. In a heterogeneous treatment-seeking, outpatient, alcoholic population, we tested the hypothesis that age of onset represents a continuum of disease, and that greater severity of psychopathology is associated with lower ages of onset. Using a standard questionnaire, 253 male and female treatment-seeking alcoholics were stratified according to specific ages of onset: a) < 20 years; b) 20-25 years, and c) > 25 years. These age of onset groups were compared on alcohol severity and craving, family history, childhood behavior, personality, hostility, overt aggression, mood, and social functioning. Symptom severity and age of onset were negatively correlated, and the 20-25-year onset group usually had intermediate scores. The < 20 year onset group was characterized by greater severity of alcohol-related problems, family history, childhood behavioral problems, craving, hostility, antisocial traits, mood disturbance, and poor social functioning. Alcoholics with an earlier age of onset have relatively greater psychopathology than those of later onset. While the preponderance of psychopathology among those in the < 20-year onset group could be conceptualized as a clinical "subtype," such a characterization would not define an entirely homogeneous category. Yet, this clinical characterization would be clinically important if specific age of onset levels were found to be differentially sensitive to pharmacological and/or psychological treatments.
Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)‐induced ubiquitin‐like ISG15 protein

Of the several hundred proteins induced by interferon (IFN) α/β, the ubiquitin‐like ISG15 protein is one of the most predominant. We demonstrate the novel way in which the function of the ISG15 protein is inhibited by influenza B virus, which strongly induces the ISG15 protein: a specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 to its target proteins both in vitro and in infected cells. We identify UBE1L as the E1 enzyme that catalyzes the first activation step in the conjugation of ISG15, and show that the NS1B protein inhibits this activation step in vitro. Influenza A virus employs a different strategy: its NS1 protein does not bind the ISG15 protein, but little or no ISG15 protein is produced during infection. We discuss the likely basis for these different strategies.
Upregulation of Glutamate–Aspartate Transporter by Glial Cell Line–Derived Neurotrophic Factor Ameliorates Cell Apoptosis in Neural Retina in Streptozotocin‐Induced Diabetic Rats

Dysfunction of glutamate uptake, largely mediated by the glutamate–aspartate transporter (GLAST), may lead to retinal cell apoptosis in diabetic retinopathy. The aim of this study is to examine how cell apoptosis and the expression level of GLAST in neural retina of a diabetic rat model are changed and whether the neuroretinal apoptosis could be ameliorated by the administration of glial cell line–derived neurotrophic factor (GDNF).
Experiments on spectrogram reading

This paper presents the results of several spectrogram reading experiments that were designed to determine the amount of phonetic information that is contained in the speech signal. The task involved identifying the phonetic content of an unknown utterance only from a visual examination of the spectrogram. In the first experiment, one of the authors attempted to phonetically label spectrograms of normal and anomalous English utterances as well as words in a known carrier phrase. The results, when compared with the transcriptions of three phoneticians who listened to the utterances, indicated an overall agreement of better than 85% on the sentences, and 93% for words in a carrier phrase. In the second and third experiments, we investigated the speed at which spectrogram reading can be accomplished. In the final experiment, five students read spectrograms of normal English sentences after a 13-week course in acoustic phonetics. Working as a group, the class agreed with the transcribers on over 80% of the segments. Implications for speech recognition and aids for the deaf are discussed.
Investigation of BCL-2 gene rearrangements in a United Kingdom series of low and high grade non-Hodgkin's lymphomas.

Rearrangements of the BCL-2 gene are thought to be the most frequent genetic changes that occur in non-Hodgkin's lymphomas (NHL), and are particularly associated with follicular low grade disease. Wide variations in the frequency of these rearrangements have, however, been reported in studies of NHL series from different parts of the world. We were therefore interested to determine the frequency of BCL-2 gene rearrangements in the different grades of NHL from a U.K. series. We have done this by using a combination of Southern blot hybridization and polymerase chain reaction (PCR) analysis. The frequencies of rearrangements in our series were 9/20 (45%) in low grade follicular NHL, 1/8 (12.5%) in low grade lymphocytic and 5/19 (26%) in high grade NHL. However, estimation of the high grade value was complicated by the fact that a number of the high grade samples in our series were from patients who had transformed from low grade follicular disease. If the patients were ranked on the basis of whether they had a history of low grade follicular disease then the frequency of BCL-2 rearrangement remained the same 13/29 (45%), but was only 1/10 (10%) in high grade NHL with no history of follicular disease. The former figure was intermediate between those reported for the USA and Japan series, but the latter high grade figure was the lowest reported from any series. The significance of BCL-2 rearrangements in the evolution of both low and high grade NHL is discussed.
Ribozyme-Catalyzed Transcription of an Active Ribozyme

A functional RNA has been synthesized by an RNA enzyme from mononucleotide building blocks. A critical event in the origin of life is thought to have been the emergence of an RNA molecule capable of replicating a primordial RNA “genome. ” Here we describe the evolution and engineering of an RNA polymerase ribozyme capable of synthesizing RNAs of up to 95 nucleotides in length. To overcome its sequence dependence, we recombined traits evolved separately in different ribozyme lineages. This yielded a more general polymerase ribozyme that was able to synthesize a wider spectrum of RNA sequences, as we demonstrate by the accurate synthesis of an enzymatically active RNA, a hammerhead endonuclease ribozyme. This recapitulates a central aspect of an RNA-based genetic system: the RNA-catalyzed synthesis of an active ribozyme from an RNA template.
Zeeman splitting in OH megamasers

Abstract We detected significant Zeeman splitting in the 1667 MHz OH megamaser emission from four ultraluminous galaxies. These detections, in addition to being the first extragalactic detection of the Zeeman effect in an emission line, suggest that OH megamasers are excellent extragalactic magnetometers.
Major depressive episodes and work stress: results from a national population survey.

OBJECTIVES We determined the proportion of workers meeting criteria for major depressive episodes in the past year and examined the association between psychosocial work-stress variables and these episodes. METHODS Data were derived from the Canadian Community Health Survey 1.2, a population-based survey of 24324 employed, community-dwelling individuals conducted in 2002. We assessed depressive episodes using the Composite International Diagnostic Interview. RESULTS Of the original sample, 4.6% (weighted n=745948) met criteria for major depressive episodes. High job strain was significantly associated with depression among men (odds ratio [OR]=2.38; 95% confidence interval [CI]=1.29, 4.37), and lack of social support at work was significantly associated with depression in both genders (men, OR=2.70; 95% CI=1.55, 4.71; women, OR=2.37; 95% CI=1.71, 3.29). Women with low levels of decision authority were more likely to have depression (OR=1.59; 95% CI=1.06, 2.39) than were women with high levels of authority. CONCLUSIONS A significant proportion of the workforce experienced major depressive episodes in the year preceding our study. Gender differences appear to affect work-stress factors that increase risk for depression. Prevention strategies need to be developed with employers and employee organizations to address work organization and to increase social support.