Miracle-dz/UniFAR-FTUs huggingface dataset:
Exercise and the right ventricle: a potential Achilles’ heel

Exercise is associated with unequivocal health benefits and results in many structural and functional changes of the myocardium that enhance performance and prevent heart failure. However, intense exercise also presents a significant hemodynamic challenge in which the right-sided heart chambers are exposed to a disproportionate increase in afterload and wall stress that can manifest as myocardial fatigue or even damage if intense exercise is sustained for prolonged periods. This review focuses on the physiological factors that result in a disproportionate load on the right ventricle during exercise and the long-term consequences. The changes in cardiac structure and function that define 'athlete's heart' disproportionately affect the right-sided heart chambers and this can raise important diagnostic overlap with some cardiac pathologies, particularly some inherited cardiomyopathies. The interaction between exercise and arrhythmogenic right ventricular cardiomyopathy (ARVC) will be highlighted as an important example of how hemodynamic stressors can combine with deficiencies in cardiac structural elements to cause cardiac dysfunction predisposing to arrhythmias. The extent to which extreme exercise can cause adverse remodelling in the absence of a genetic predisposition remains controversial. In the athlete with profound changes in heart structure, it can be extremely challenging to determine whether common symptoms such as palpitations may be a marker of more sinister arrhythmias. This review discusses some of the techniques that have recently been proposed to identify pathology in these circumstances. Finally, we will discuss recent evidence defining the role of exercise restriction as a therapeutic intervention in individuals predisposed to arrhythmogenic cardiomyopathy.
[Nocturia in obstructive sleep apnoea (OSA)].

INTRODUCTION Nocturia (two or more urinations per night) is a common symptom in OSA subjects. Higher secretion of atrial natriuretic peptide, increased intra-abdominal pressure, diuretics, diabetes, excessive fluid intake, awakenings are responsible for nocturnal urination. The aim of this study was to evaluate incidence of nocturia in moderate and severe OSA. MATERIAL AND METHODS We studied 171 consecutive OSA patients (135 males and 36 females) - means: age - 53.6 +/- +/- 10.8 years, AHI/RDI - 43.6 +/- 23.2, BMI - 35.8 +/- 6.3 kg/m(2). RESULTS To assess relations between nocturia and AHI/RDI, overnight saturation, BMI and daytime sleepiness we divided subjects in two groups: 1(st) - without nocturia - 60 pts; 35.1% (group N-) and 2(nd) - with nocturia - 111 pts; 64.9% (group N+). Group N+ presented with higher AHI/RDI, 48 +/- 22.8 vs. 35.4 +/- 21.7 (p = 0.0006), higher BMI, 36.8 +/- 6.5 vs. 34 +/- 5.5 kg/m(2) (p = 0.004), lower mean overnight SaO(2), 88.6 +/- 5.6 vs. 90.4 +/- 4.3% (p = 0.03) and daytime sleepiness, Epworth score - 14.4 +/- 5.1 vs. 11.3 +/- 5.5 points (p = 0.0002). Multiple linear regression analysis revealed significant correlation between nocturia and Epworth sleepiness score (beta = 0.26, p = 0.0009), coronary artery disease (beta = 0.23, p = 0.004) and AHI/RDI (beta = 0.21, p = 0.04). CONCLUSIONS Nocturia is frequent in OSA patients (64.9%). Nocturnal urination was related to severity of OSA, excessive daytime sleepiness and coronary artery disease.
Leader‐member exchange and attitudinal outcomes: role of procedural justice climate

Purpose – Building upon the “fair exchange in leadership” notion (Hollander; Scandura), the purpose of this paper was to hypothesize the mediating impact of procedural justice climate on the relationship between leader‐member exchange (LMX) and two attitudinal outcomes: organizational commitment and turnover intentions.Design/methodology/approach – A total of 224 managers voluntarily participated in the study. They represented nine multinational companies located in northern Malaysia. Data were collected by means of a structured questionnaire containing widely used scales to measure LMX (contribution, affect, loyalty, and professional respect), procedural justice climate, organizational commitment (affective, normative, and continuance), and turnover intentions. After establishing the goodness of measures, hypothesized relationships were examined using Structural Equation Modeling (SEM). While commitment and LMX were, respectively, conceptualized as 3‐ and 4‐dimensional constructs, procedural justice clim.
The R71G BRCA1 is a founder Spanish mutation and leads to aberrant splicing of the transcript

In a BRCA1 screening in familial breast cancer carried out in different centres in Spain, France, and United Kingdom, a missense mutation 330A>G which results in a Arg to Gly change at codon 71 (R71G) was independently identified in 6 families, all of them with Spanish ancestors. This residue coincides with the ‐2 position of the exon 5 donor splice site. We further investigated the effect of this base substitution on the splicing of BRCA1 mRNA. The sequence analysis of the cDNA indicated that 22 bp of exon 5 were deleted, creating with the first bases of exon 6 a termination codon at position 64, which results in a truncated protein. The BRCA1 haplotype of the R71G carrier patients and Spanish controls was analysed by use of six microsatellites located within or near BRCA1. Our results are consistent with the possibility that these families shared a common ancestry with BRCA1 R71G being a founder mutation of Spanish origin. Hum Mutat 17:520–521, 2001. © 2001 Wiley‐Liss, Inc.
Epoetin beta (NeoRecormon) therapy in patients with solid tumours receiving platinum and non-platinum chemotherapy: a meta-analysis.

BACKGROUND Anaemia is a common complication of chemotherapy (CT), including both non-platinum (Pt)-based as well as Pt-based CT. PATIENTS AND METHODS Patients from three controlled trials with solid tumours receiving either Pt- or non-Pt-based CT, who had been randomised to epoetin beta treatment or standard care, were included in this meta-analysis (n=255, n=199, respectively), to see if epoetin beta was equally effective in both CT types. The primary endpoint was haemoglobin (Hb) change. Secondary end-points included transfusion requirement, adverse events (AEs), survival, time to tumour progression and thromboembolic events (TEEs). RESULTS All patients responded rapidly to epoetin beta treatment, showing a median Hb increase of > or = 1 g/dl from baseline at week 4. A median Hb of 12.2, 12.5 and 11.8 g/dl was achieved in all patients, those receiving Pt-based CT and those receiving non-Pt-based CT, respectively, after 16 weeks of treatment. Transfusion risk reductions associated with epoetin beta treatment of 53% (p<0.0001), 61% (p<0.0001) and 26% (non significant) were observed for all patients, Pt- and non-Pt-based CT patients, respectively. Overall, for all three populations, there were no risks identified for tumour progression or overall survival. There was a statistically non-significant incidence of TEEs (5.9% versus 4.5%) and no marked differences were observed between groups for frequency or type of AEs reported. CONCLUSION The type of CT has no impact on the ability of epoetin beta to rapidly increase Hb in patients with solid tumours and CT-induced anaemia.
Non-toxic Antifouling Activity of Polymeric 3-alkylpyridinium Salts from the Mediterranean Sponge Reniera sarai (Pulitzer-Finali)

The antifouling activity and toxicity of polymeric 3-alkylpyridinium salts (poly-APS) isolated from the Mediterranean sponge Reniera sarai were studied. The activity of these natural products was compared to that of zinc and copper complexes of pyrithione, two non-persistent booster biocides successfully used in current antifouling coatings. Larvae of Balanus amphitrite (cyprids and nauplii) were used to monitor settlement inhibition and the extent to which inhibition was due to toxicity. The microalga Tetraselmis suecica and larvae of the mussel Mytilus galloprovincialis were used in toxicity bioassays. Compared to the booster biocides, poly-APS were less effective at inhibiting cyprid settlement, but their effects were non toxic and reversible, with very low toxicity against the organisms used in the toxicity bioassays. Although encouraging, these results are not enough to warrant the use of poly-APS as a potential commercial antifoulant. They however justify possible future efforts to chemically synthesize poly-APS analogues for further tests.
Ultraviolet C light pathogen inactivation treatment of platelet concentrates preserves integrin activation but affects thrombus formation kinetics on collagen in vitro

Ultraviolet (UV) light illumination in the presence of exogenously added photosensitizers has been used to inactivate pathogens in platelet (PLT) concentrates for some time. The THERAFLEX UV‐C system, however, illuminates PLT concentrates with UV‐C light without additional photoactive compounds. In this study residual PLT function is measured in a comprehensive paired analysis of UV‐C–treated, gamma‐irradiated, and untreated control PLT concentrates.
The Effect of a Training Program in Communication Skills on Primary Health Care Physicians' Knowledge, Attitudes and Self-efficacy.

UNLABELLED Communication has been identified as one of the core clinical skills for all health care providers, but it is especially important for primary health care disciplines. Findings suggest the need for more attention to communication skills in continued physician education. This work aims at evaluating the effect of a communication skills training program on physicians' knowledge, attitude and self efficacy related to communication. In this pretest- posttest intervention study, a three-day, 18-hour training program was developed and implemented. The teaching method was learner-centered and includes theoretical information, practical applications and attitude change. A self administered questionnaire was used to evaluate the program. The results showed significant improvement in physicians' knowledge about communication where those having good knowledge increased from 13.1% before the intervention to 82% after the intervention. Physicians reported significantly higher confidence levels in their ability to build rapport with patients, counsel patients for smoking cessation and medication adherence after the intervention. CONCLUSION Overall, in this study we found that training in communication skills improves clinicians' knowledge, changes some negative attitudes and enhances assessment of physicians' own ability to perform specific communication tasks.
Trauma exposure and posttraumatic stress disorder in delinquent female adolescents.

BACKGROUND Although juveniles within the justice system have high psychiatric morbidity, few comprehensive investigations have shown posttraumatic stress disorder (PTSD) in female delinquents. Here, we aim to describe the nature and extent of PTSD and trauma exposure and to clarify the relationships among comorbidity and psychosocial factors in juvenile female offenders. METHOD Sixty-four girls were randomly interviewed using structured tools. Self-report measures were used to assess depression, eating behaviour, impulsivity and parental attitude. RESULTS The PTSD prevalence was 33%, and 77% of the female juvenile offenders had been exposed to trauma. The offenders with PTSD showed a significantly high psychiatric comorbidity. Depression and adverse parenting were associated with PTSD development, and abnormal eating was also correlated with PTSD symptoms. Marked differences in the frequency and intensity of PTSD evaluation depending on the type of comorbidity and trauma were observed. CONCLUSIONS Incarcerated young females in Japan have serious trauma-related problems, and the degree of depression is a strong predictor of PTSD development and symptoms. This study highlights the importance of adequate diagnosis and treatment of PTSD in delinquent female adolescents.
Effects of prebiotics and probiotics on the colonization and immune response of broiler chickens challenged with Salmonella enteritidis

The present study aimed at evaluating the effect of the prebiotic Bio Mos™ (2 kg/ton up to 10 days; 1 kg/ton from 10 to 21 days; and 0.5 kg/ ton from 21 days to slaughter), of the probiotic Lac XCL 5x™ (by spraymixing), of a combination of the two supplements (prebiotic + probiotic), and of one growth promoter antimicrobial agent (Avilamycin at 15 ppm). Birds were orally challenged with inoculated Salmonella Enteritidis (SE) 10 6 CFU at 3 days of age. Four hundred and eighty male Ross chicks were used. The experiment lasted 28 days, and the analyses were conducted at 15 and 28 days of age. Cecum and liver bacterial colonization of production of anti-SE antibiodies, intestinal micrometry and bird performance were assessed. Neither the prebiotic, nor the probiotic influenced performance or production of anti-SE antibodies in SE-challenged birds. Intestinal micrometry and bird mortality were not influenced by prebiotic or probiotic supplementation, or by the antimicrobial agent. The use of an antimicrobial agent produced higher SE CFUs in cecum bacterial counts, while prebiotic and probiotic yielded lower counts. The combination prebiotic+probiotic did not produce significantly different results from the individual use of the additives.
Identifying Universal Laws of Text Translation

Straightforward quantitative analyses of authentic texts have allowed linguists and translation scholars to discern patterns in individual languages as well as features which set translations apart from originals. A language can also be studied statistically, an approach epitomized by the application of Zipf’s Law, which states that word-frequency distributions follow an almost identical curve regardless of language. To date, no universal law governing the joint probability distribution of words in two or more languages has been either proposed or observed. This study identifies new universal behaviours which characterize the mutual overlaps between a corpus of original English and three corpora of translated English. Specifically, it suggests a remarkable similarity in (a) the number of types unique to each translated corpus, and (b) the number of types common to the original-English corpus and each of the translated corpora. We argue that these universal behaviours can be used both to determine the ontological status of an unidentified
Prenatal high‐dose immunoglobulin treatment for neonatal hemochromatosis: A case report and review of the literature

Neonatal hemochromatosis is a difficult disorder to cure, and it has a high rate of recurrence. High‐dose immunoglobulin treatment is very effective as prenatal treatment for recurrent neonatal hemochromatosis. A 34‐year‐old pregnant Japanese woman underwent high‐dose immunoglobulin treatment for recurrent neonatal hemochromatosis. High‐dose non‐specific intravenous immunoglobulin (1 g/kg bodyweight) was administered to the mother intravenously every week from 18 until 36 gestational weeks. A male infant was delivered at 37 weeks of gestation, and his condition was favorable, including hepatic function. The use of γ‐globulin for neonatal hemochromatosis appears adequately validated by experience.
5'-NUCLEOTIDASE AND AN ACID PHOSPHATASE OF SPINAL CORD COMPARATIVE HISTOCHEMISTRY AND SPECIFICITY OF THE ENZYMES IN MOUSE AND CAT SPINAL CORDS. CYTOLOGIC LOCALIZATION IN MOUSE SUBSTANTIA GELATINOSA

Histochemical procedures show a concentrated zone of phosphomonoesterase activity in the substantia gelatinosa of mouse spinal cord which represents at least two enzymic activities. At pH 7,5'-nucleotidase activity is observed in both somata and neuropil, while at pH 5 the reaction is evident only in somata. An acid phosphatase of unknown specificity is seen in somata only and exhibits optimal activity near pH 5. No comparable enzymic reactions are observed in cat spinal cord sections. Electron microscopic studies demonstrate separate cytologic distributions of the two enzymic activities in substantia gelatinosa. With nucleotides, the reaction is confined to boundaries of processes within the neuropil and to nuclei at pH 7. At pH 5 using an acid phosphatase substrate, β-glycerol phosphate, slight reactions were noted within nerve fibers. Use of β-glycerol phosphate near pH 7 demonstrates both types of activity simultaneously, the boundary reactions typical of the nucleotidase and the reactions within axons and dendrites characteristic of the phosphatase.
Invasions of Personal Space in Demented and Nondemented Elderly Persons

Personal space has been a research issue in both social psychology and nursing in the past 20 years. In the context of behavioral and psychological signs and symptoms in dementia (BPSSD), however, personal space and other basic paradigms of social psychology sparsely play a role. In order to assess personal space in demented (n = 10) and nondemented (n = 10) elderly participants, we replicated the original study addressing personal space by Felipe and Sommer (1966). The two groups differed in the overall number of participants showing a specific reaction, in the mean duration until specific reactions occurred, and in the percentage of participants within a group showing a specific reaction at a given point in time. The argument is being made that such findings might reflect situational as well as disease-specific changes in the perception of and reactions to invasions of personal space in demented patients. We suggest that further research in that field could bring about more information on the nature of dementia, and especially BPSSD. Implications for therapy and care of dementia patients are being discussed.
Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target

Early treatment with heart failure drugs lisinopril and spironolactone improves skeletal muscle pathology in Duchenne muscular dystrophy (DMD) mouse models. The angiotensin converting enzyme inhibitor lisinopril and mineralocorticoid receptor (MR) antagonist spironolactone indirectly and directly target MR. The presence and function of MR in skeletal muscle have not been explored. MR mRNA and protein are present in all tested skeletal muscles from both wild‐type mice and DMD mouse models. MR expression is cell autonomous in both undifferentiated myoblasts and differentiated myotubes from mouse and human skeletal muscle cultures. To test for MR function in skeletal muscle, global gene expression analysis was conducted on human myotubes treated with MR agonist (aldosterone; EC50 1.3 nM) or antagonist (spironolactone; IC50 1.6 nM), and 53 gene expression differences were identified. Five differences were conserved in quadriceps muscles from dystrophic mice treated with spironolactone plus lisinopril (IC50 0.1 nM) compared with untreated controls. Genes down‐regulated more than 2‐fold by MR antagonism included FOS, ANKRD1, and GADD45B, with known roles in skeletal muscle, in addition to NPR3 and SERPINA3, bona fide targets of MR in other tissues. MR is a novel drug target in skeletal muscle and use of clinically safe antagonists may be beneficial for muscle diseases. — Chadwick, J. A. , Hauck, J. S. , Lowe, J., Shaw, J. J., Guttridge, D. C. , Gomez‐Sanchez, C. E. , Gomez‐Sanchez, E. P., Rafael‐Fortney, J. A. Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target. FASEB J. 29, 4544‐4554 (2015). www.fasebj. org
Organization, Development and Enucleation‐induced Alterations in the Visual Callosal Projection of the Hamster: Single Axon Tracing with Phaseolus vulgaris leucoagglutinin and Di‐l

The distribution of callosal axons interconnecting lateral area 17 and medial area 18 of the rodent's occipital cortex is dramatically altered by neonatal enucleation, but it is not known how this manipulation affects the morphology of individual callosal axons or whether the enucleation‐induced changes in this pathway reflect maintenance of a transient developmental state by these fibres. In the present study, these questions were addressed by tracing the individual callosal axons in normal adult and neonatally enucleated adult hamsters with Phaseolus vulgaris leucoagglutinin (PHAL) and by anterograde labelling of developing callosal axons with the carbocyanine dye, Di‐l. In normal adults, injections of PHAL into the region of the 17–18a border produced dense labelling in all layers in the region of the contralateral 17–18a border. Larger injections resulted in callosal labelling that extended across the lateral one‐half of area 17, primarily in layers l and V. Thirty‐four callosal axons from normal adult hamsters were reconstructed through all the cortical laminae. Most of these had very simple terminal arbors. They gave off short collaterals in the infragranular layers and branched more extensively in the uppermost part of layer II‐III and in lamina l. Small injections of PHAL into the occipital cortex of neonatally enucleated adult hamsters resulted in labelled axons throughout most of areas 17 and 18a in the contralateral hemisphere. The terminal arbors of most individual callosal axons in eyeless hamsters were not appreciably different from those in sighted animals. However, 26.8% of 28 fibres reconstructed through all cortical laminae in the neonatally enucleated hamsters had much more widespread branches than any of the axons recovered from normal hamsters. As a result, the average total length of the callosal axons from the blinded hamsters was significantly greater than that for such fibres from the sighted animals. Anterograde labelling with Di‐l demonstrated axons in the anterior commissure and anterior part of the corpus callosum on P‐O. Labelled fibres extended into the white matter underlying the occipital cortex on P‐1 and entered the cortical plate on P‐2. Some of these axons reached into the marginal layer. Many developing callosal axons had short branches in the white matter, but generally extended only a single collateral into the cortical grey matter. Callosal axons in perinatal animals branched very little within the cortex and, in this respect, resembled fibres labelled with PHAL in adult hamsters. These results support the conclusion that the expanded tangential distribution of the occipital callosal projection in neonatally enucleated adult hamsters results, at least in part, from individual axons with abnormally widespread terminal arbors which are not present in large numbers at any time during normal development.