Miracle-dz/UniFAR-FTUs huggingface dataset:
Peritoneal carcinomatosis from cervical cancer detected by F-18 FDG positron emission tomography.

A 41-year-old woman with a history of rheumatoid arthritis and newly diagnosed cervical carcinoma was treated with cisplatin and whole-pelvis radiotherapy with minimal response. Computed tomographic scan of the abdomen and pelvis at the time of diagnosis demonstrated no evidence of extrapelvic disease. She underwent F-18 fluorodeoxyglucose (FDG-PET) imaging to evaluate for extrapelvic extension of disease for consideration of total pelvic exenteration. Coronal and axial reconstructed images revealed a large pelvic mass with evidence of diffuse FDG uptake along the peritoneal surfaces of the abdomen and pelvis, consistent with diffuse peritoneal implants. Subsequent diagnostic laparoscopy demonstrated a large omental cake with diffuse carcinomatosis, biopsy positive for metastatic squamous cell carcinoma, and a small amount ofascites. The patient declined further treatment and died of her disease approximately one month later.
Effect of organic toxicants on the activity of denitrifying granular sludge

Denitrification plays a key role in the biological nitrogen removal from the wastewater using granular sludge as the integral part of a high-rate denitrification technology. It is helpful to evaluate the effect of typical organic toxicants on the activity of denitrifying granular sludge for the application of denitrification technology. In this study, four typical organic toxicants, namely, penicillin, chloramphenicol, 2,4-dinitrophenol and polymyxin B sulphate were used to assess the effect of organic toxicants on the activity of denitrifying granular sludge. The results of individual toxicity indicated that penicillin, chloramphenicol and 2,4-dinitrophenol had significant inhibition, whose half-inhibitory concentrations were 0.534, 0.162 and 0.474 g/L with respective inhibitory magnitudes of 90.79%/(g/L), 282.5%/(g/L) and 138.83%/(g/L). Polymyxin B sulphate showed no significant inhibition. The results of combined toxicity indicated that the binary mixture of penicillin and chloramphenicol had an antagonistic effect, both the binary mixture of penicillin and 2,4-dinitrophenol and the binary mixture of chloramphenicol and 2,4-dinitrophenol had additive effects. The ternary mixture of penicillin, chloramphenicol and 2,4-dinitrophenol had a partial additive effect.
Does Hypereosinophilic Syndrome Precede Common B Acute Lymphoblastic Leukaemia in Childhood? A Case Report

Hypereosinophilic syndrome (HES) and the association of hypereosinophilia with acute lymphoblastic leukaemia (ALL) are both rare in children. Some acute myelogenous leukaemias can present with eosinophilia, but the relationship between HES and ALL is not well known and is rarer than the relationship between HES and acute myelogenous leukaemia. Patients are diagnosed with HES when no cause is found to explain the eosinophilia leading to end organ damage. For this reason, it is recommended that patients presenting with hypereosinophilia be carefully assessed to exclude any malignant clonal proliferation. HES may present with severe clinical manifestations such as high leucocyte count, anaemia, thrombocytopaenia, hepatosplenomegaly or cardiac and neurological involvement, all of which are primarily features of myeloproliferative disorders. Some patients with HES can develop chronic eosinophilic leukaemia. Successful treatment of HES with agents used in chronic myeloid leukaemia supports the idea that HES can be a chronic myeloid disorder. There are few cases reporting an association between ALL and hypereosinophilia that precedes or is concomitant with ALL. Here we report the case of a 14-year-old girl who developed common B ALL 7 months after diagnosis and treatment of HES. Interestingly, eosinophilia was not concomitant with the diagnosis of ALL.
Memory Complaints in Medically Refractory Epilepsy: Relationship to Epilepsy-Related Factors

This study reports the results of a multicenter study on memory complaints in 252 patients with epilepsy who presented with subjective complaints about memory problems in daily life. Memory complaints were measured with a standardized memory questionnaire (GKLE). The main purpose was to analyze the type of memory complaints and to examine the relationship between subjective complaints and several epilepsy-related factors. These include seizure type, lateralization and location of the focus, etiology, duration, age at onset, and antiepileptic medication. As expected patients experienced significantly more memory complaints. In particular, patients of older age and higher intelligence level complained more about their memory functioning. Although the clinical significance is marginal, neuroticism showed a significant relationship to the total complaint score. The total amount of subjective complaints is not related to the localization or lateralization of the epileptic disturbances. Patients with a longer duration of epilepsy complained significantly more about memory problems, especially about retrieving information from memory. All other epilepsy-related factors showed no relationship to memory complaints.
Antipsychotic polypharmacy, Part 1: Therapeutic option or dirty little secret?

Antipsychotic polypharmacy is a surprisingly frequent occurrence that can be both justified and unjustifed, depending on how it is used. To the extent that this phenomenon has been unrecognized and is not being studied, it is a "dirty little secret. " To the extent that careful clinicians have uncovered a useful strategy for boosting the effectiveness of available antipsychotic monotherapies, it represents an opportunity to improve the outcomes of patients with psychotic illnesses.
Near-Infrared Spectroscopy of Powerful Radio Galaxies at z = 2.2-2.6

Near-infrared spectroscopy (λrest ~ 3700-6800 Å) of eight high-redshift powerful radio galaxies (HzPRGs) at z = 2.2-2.6 is presented. Strong forbidden lines and Hα emission were detected in all sources; the data show evidence that the emission lines of the HzPRGs may contribute a substantial fraction (~25%-98%) of their total observed H- and/or K-band light. Diagnostic emission-line ratios— [O III] λ5007/Hβ versus [S II] λλ6716, 6731/Hα—for three of the eight HzPRGs are consistent with the presence of a Seyfert 2 nucleus; the [O III] λ5007/Hβ and [S II] λλ6716, 6731/Hα ratios and/or limits of the remaining five galaxies are inconclusive. Furthermore, all six of the galaxies for which both H- and K-band spectra were obtained have observed [O III] λ5007/(Hα + [N II] λλ6548, 6583) ratios consistent with Seyfert 2 ionization. Much of the inability to detect the weaker emission lines of [S II] λλ6716, 6731 in three of the galaxies and Hβ in any of the galaxies may be caused by moderate amounts of dust: for the two sources with previously measured Lyα fluxes, the observed Lyα/Hα ratios are ~1.5, much less than the value of 16 expected for gas in a dust-free medium photoionized by a hard, nonthermal continuum. If such a discrepancy is caused solely by dust, this ratio translates into AV ~ 0.5-1.0 mag (depending on which extinction curve—Milky Way, SMC, or LMC—is used) at the rest frame optical wavelengths of the galaxies and a corresponding factor of ~1.6-2.5 reduction in optical flux. None of the eight HzPRGs at z = 2.2-2.6 has a broad (ΔvFWHM > 1500 km s-1) emission-line core, and it is not clear whether any have broad emission-line wings. However, the near-infrared spectrum of 3C 22, a z = 0.937 radio galaxy with 1 μm luminosity comparable to that of the radio galaxies at z = 2.2-2.6 and a radio luminosity only 3-5 times less, shows direct evidence for broad Hα emission wings. Such a feature is indicative of the presence of a partially obscured Seyfert 1 nucleus. Given that 3C 22 is at ~1/3 the luminosity distance of the sample of HzPRGs at z = 2.2-2.6, a thorough search for such a faint feature in the more distant galaxies may require 8-10 m class telescopes. These new data, along with recent UV-to-optical polarimetry showing evidence of high polarization in many HzPRGs, provide evidence that many HzPRGs are predominantly ionized by an active nucleus, and that a significant fraction of their spectral energy distribution may be caused by nonthermal emission from an active galactic nucleus (AGN).
DNA Methylation Profiles of Lung Tumors 1

Aberrant methylation of CpG islands in promoter regions of tumor cells is one of the major mechanisms for silencing of tumor suppressor genes. We determined the frequency of aberrant promoter methylation of the p16, adenomatous polyposis coli (APC), H-cadherin (CDH13), glutathione S-transferase P1 (GSTP1), O-methylguanine-DNA-methyltransferase (MGMT), retinoic acid receptor -2 (RAR ), E-cadherin (CDH1), and RAS association domain family 1A (RASSF1A) genes in 198 tumors consisting of small cell lung cancers [SCLCs (n 43)], non-small cell lung cancers [NSCLCs (n 115)], and bronchial carcinoids (n 40). The profile of methylated genes in the two neuroendocrine tumors (SCLC and carcinoids) were very different from that of NSCLC. However, whereas the overall pattern of aberrant methylation of carcinoids was similar to that of SCLC, carcinoids had lower frequencies of methylation for some of the genes tested. There were also significant differences in the methylation profiles between the two major types of NSCLC, adenocarcinoma and squamous cell carcinoma. We performed cluster analysis and found that SCLCs clustered with other SCLCs and carcinoids but not with NSCLCs, whereas the NSCLCs tended to cluster together. Within NSCLCs, adenocarcinomas and squamous cell carcinomas clustered with their respective histological types. Finally, we compared the methylation profiles of SCLC and NSCLC tumors and their respective cell lines (n 44). In general, methylation frequencies were higher in tumor cell lines, but these differences were seldom significant. Thus, tumor cell lines appear to be suitable models to study aberrant DNA methylation. We conclude that SCLC, carcinoids, squamous cell carcinomas, and adenocarcinomas of the lung have unique profiles of aberrant methylation. Our findings should help us understand differences in the pathogenetic mechanisms of lung cancers.
Heroes made here: an analysis of rhetoric devices in Les Mills advertising

Objective of the study: The purpose of this study is to examine the types of rhetorical devices that are used to persuade consumers to attend Les Mills group fitness classes and prefer the brand over other standardized group fitness classes. The objective is not to identify different types of rhetoric devices that are being used, but to examine what is being done with these representations and how they might correlate with the current fitness discourse. As rhetoric devices can always be interpreted in various ways and arguments are bound to be subjected to the addressee’s individual evaluation, this study will also evaluate the possible counterarguments and criticism the constructed message may face. Research method: The methodology used is based on rhetorical analysis, which resides in the field of discourse analysis. In rhetorical discourse analysis, the processes of producing meanings are analyzed: how the meanings are constructed as convincing and desirable versions of reality and how the audience is persuaded to commit to those versions. As rhetorical discourse analysis is based on the interpretative nature of reality, there is no unambiguous way of knowing what sorts of attitudes an actor producing meanings has towards the reality. Therefore, the purpose of this study is not to find out what the proposed meaning of the advertisements is as such, but rather through the arguments that are being made for the subject. Although rhetorical analysis is often seen as a subordinate to discourse analysis, this study addresses discourse also as a tool of rhetoric. The prevalent fitness discourse is suggested to have so much importance that it in itself can be used as an underlying means for persuading audiences. Findings: Four common themes among rhetorical devices were identified: metaphors, quantification, categorization and narratives. These findings were then paired with the findings of Smith Maguire (2002) on recurring themes within the fitness industry discourse: the dilemma of exercise as hard work versus leisure, fitness as a lifestyle choice, fitness as a source for calculable rewards and motivational dilemma. It is suggested that metaphors are linked with the dilemma of viewing exercise as either work or leisure, whereas quantification attends both the motivational dilemma and considering fitness as a source for calculable rewards. Categorization addresses mostly the motivational dilemma and narratives are linked with viewing fitness as a lifestyle choice.
Blunting of Circadian Rhythms and Increased Acrophase Variability in Sleep‐Time Hypertensive Subjects

24 h and ultradian rhythms of blood pressure (BP) have been previously shown to be disorganized in nocturnal hypertensive subjects. The present study was undertaken to further analyze the ultradian and circadian BP rhythm structure in sleep‐time hypertensive subjects with normal or elevated awake‐time BP levels. Fourier analysis was used to fit 24, 12, 8, and 6 h curves to mean BP as well as heart rate (HR) time series data derived from 24 h ambulatory blood pressure monitoring. Awake and sleep periods were defined according to individual sleep diaries. Awake‐time hypertension was defined as diurnal systolic (SBP) and/or diastolic BP (DBP) means ≥135/85 mmHg. Sleep‐time hypertension was defined as nocturnal SBP and/or DBP means ≥120/70 mmHg. The sample included 240 awake‐time normotensive subjects (180 sleep‐time normotensives and 60 sleep‐time hypertensives) and 138 untreated awake‐time hypertensive subjects (31 sleep‐time normotensives and 107 sleep‐time hypertensives). The amplitude and integrity (i.e., percent rhythm) of the 24 and 12 h BP rhythms were lower in the sleep‐time hypertensive subjects and higher in the awake‐time hypertensive subjects. However, no differences were detected when the integrity and amplitude of the 6 and 8 h mean BP rhythms were analyzed. The sleep‐time hypertensive group showed significantly higher 24 h BP rhythm acrophase variability. No differences could be found in any of the HR rhythm parameters. Altogether, the findings suggest a disorganization of the BP circadian rhythm in sleep‐time hypertensives that results in reduced 24 h rhythm amplitude and integrity that could be related to cardiovascular risk.
Hypovitaminosis D in medical inpatients.

BACKGROUND Vitamin D deficiency is a major risk factor for bone loss and fracture. Although hypovitaminosis D has been detected frequently in elderly and housebound people, the prevalence of vitamin D deficiency among patients hospitalized on a general medical service is unknown. METHODS We assessed vitamin D intake, ultraviolet-light exposure, and risk factors for hypovitaminosis D and measured serum 25-hydroxyvitamin D, parathyroid hormone, and ionized calcium in 290 consecutive patients on a general medical ward. RESULTS A total of 164 patients (57 percent) were considered vitamin D-deficient (serum concentration of 25-hydroxyvitamin D, < or = 15 ng per milliliter), of whom 65 (22 percent) were considered severely vitamin D-deficient (serum concentration of 25-hydroxyvitamin D, <8 ng per milliliter). Serum 25-hydroxyvitamin D concentrations were related inversely to parathyroid hormone concentrations. Lower vitamin D intake, less exposure to ultraviolet light, anticonvulsant-drug therapy, renal dialysis, nephrotic syndrome, hypertension, diabetes mellitus, winter season, higher serum concentrations of parathyroid hormone and alkaline phosphatase, and lower serum concentrations of ionized calcium and albumin were significant univariate predictors of hypovitaminosis D. Sixty-nine percent of the patients who consumed less than the recommended daily allowance of vitamin D and 43 percent of the patients with vitamin D intakes above the recommended daily allowance were vitamin D-deficient. Inadequate vitamin D intake, winter season, and housebound status were independent predictors of hypovitaminosis D in a multivariate model. In a subgroup of 77 patients less than 65 years of age without known risk factors for hypovitaminosis D, the prevalence of vitamin D deficiency was 42 percent. CONCLUSIONS Hypovitaminosis D is common in general medical inpatients, including those with vitamin D intakes exceeding the recommended daily allowance and those without apparent risk factors for vitamin D deficiency.
Current concepts in knee replacement: features and imaging assessment.

OBJECTIVE This article reviews current concepts of knee replacement. Features of traditional and new prosthetic designs, materials, and surgical techniques are discussed. Normal and abnormal postoperative imaging findings are illustrated. Complications are reviewed and related to the current understanding about how and why these failures occur. CONCLUSION It is well known that after knee replacement, patients with complications may be asymptomatic, and, for this reason, assessment of postoperative imaging is important. The foundation of radiologic interpretation of knee replacement is knowledge of the physiologic purpose, orthopedic trends, imaging findings, and complications.
Comparative study of virulence and virulence factors of Aeromonas hydrophila strains isolated from water and sediments of a river.

Seventy-four strains of Aeromonas hydrophila isolated from water and sediments of the River Porma (León, N.W. Spain) were characterized biochemically and biologically. Fifty-seven strains (77.02%) were virulent for rainbow trout (Salmo gairdneri) by intramuscular challenge but showed differing degree of pathogenicity which could not be associated with the source. A lack of correlation between caseinase, haemolytic and cytotoxic activities of the strains and their isolation source was also observed. Only two surface characters, acriflavine 0.2% agglutination and non-agglutinating SP-/PAB-phenotypes, were significantly associated with water and sediment strains, respectively.
Complementarity of interphase and metaphase chromosome analysis in human renal tumors

Fluorescence in situ hybridization (FISH) was used as a complement to earlier cytogenetic studies of human renal tumors. Chromosome‐specific para‐centromeric probes were applied to cells disaggregated from tissue blocks of tumors, fresh samples from which had yielded cytogenetic results after short‐term culture. Cells were dissociated from thick sections of paraffin‐embedded, formalin‐fixed tissues. Biotin‐labeled probes specific for chromosomes 1, 3, 7, 11, 12, 15, 17, and the Y chromosome were applied in individual cases and were detected by fluorescence. Probes for chromosomes 1, 7, and 17 yielded clean signals with disomic control frequencies near 90%, and 97% of controls showed a single bright spot for the Y chromosome. The 9 cases selected all provided ample numbers of dissociated cells which were hybridized successfully, although some chromosomal signals were poor in individual cases. Abnormal copy numbers of chromosomes 1 and/or 17, not identified in culture, were observed in 7 cases. Trisomy 7 observed in culture was substantiated by FISH on the original tissues, as was loss of the Y, in each of 4 cases, respectively. Our results include limited validation of culture cytogenetics, evidence of selection in culture of tumor subpopulations, and demonstration that interphase cytogenetics by FISH is applicable to archival tissue blocks after prolonged periods of storage. Conditions of culture before harvest and inherent heterogeneity within tumors permit selection for nonrepresentative subgroups within tumors and emphasize the need for multiple approaches to evaluation. © 1993 Wiley‐Liss, Inc.
Beneficial effects of tandospirone on ataxia of a patient with Machado‐Joseph disease

Abstract Tandospirone citrate (tandospirone) is an anti‐anxiety drug that acts by combining with serotonin receptor (5‐hydroxytryptamine‐1 A [5‐HT1A]). Recently, there have been a few reports of its potential role in the treatment of cerebellar ataxia. We report the first case of a patient with Machado‐Joseph disease in which we successfully treated cerebellar ataxia. In addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5‐HT1A receptors, were also remarkably alleviated by treatment with tandospirone.
Functional Expression of IL-9 Receptor by Human Neutrophils from Asthmatic Donors: Role in IL-8 Release1

Human polymorphonuclear neutrophils (PMNs) express surface receptors for various inflammatory mediators, including IgE and IL-4. Recently, the IL-9R locus has been genetically linked to asthma and bronchial hyperresponsiveness in humans. In this study, we evaluated expression of the IL-9R and the effect of IL-9 on human PMNs. RT-PCR analysis showed the presence of IL-9Rα-chain mRNA in PMN RNA preparations from asthmatic patients. Using FACS analysis, surface expression of IL-9Rα was detected on PMNs freshly isolated from asthmatics, and to a lesser extent on normal controls. In addition, protein expression of IL-9Rα was also detected in peripheral blood and bronchoalveolar lavage PMNs. Furthermore, functional studies showed that IL-9 stimulation of PMNs results in the release of IL-8 in a concentration-dependent manner. The anti-IL-9 neutralizing Ab suppressed this effect, but had no effect on GM-CSF-induced IL-8 release from PMNs. Taken together, these findings suggest a novel role for PMNs in allergic disease through the expression and activation of the IL-9R.
Prioritization of Potential Mates’ History of Sexual Fidelity During a Conjoint Ranking Task

This series of studies is the first to use conjoint analysis to examine how individuals make trade-offs during mate selection when provided information about a partner’s history of sexual infidelity. Across three studies, participants ranked profiles of potential mates, with each profile varying across five attributes: financial stability, physical attractiveness, sexual fidelity, emotional investment, and similarity. They also rated each attribute separately for importance in an ideal mate. Overall, we found that for a long-term mate, participants prioritized a potential partner’s history of sexual fidelity over other attributes when profiles were ranked conjointly. For a short-term mate, sexual fidelity, physical attractiveness, and financial stability were equally important, and each was more important than emotional investment and similarity. These patterns contrast with participants’ self-reported importance ratings of each individual attribute. Our results are interpreted within the context of previous literature examining how making trade-offs affect mate selection.