Miracle-dz/UniFAR-FTUs huggingface dataset:
Cerebral Microinfarcts Associated with Severe Cerebral β‐Amyloid Angiopathy

Cerebral amyloid angiopathy (CAA) is common in elderly individuals, especially those affected with Alzheimer's disease. Eighteen brains with severe SCAA (SCAA) were compared with 21 brains with mild CAA (MCAA) to investigate whether the presence of SCAA in the brains of demented patients was associated with a higher burden of old microinfarcts than those with MCAA. Immunohistochemistry for CD68 was employed to highlight old microinfarcts in tissue blocks from various brain regions. Old microinfarcts, manually counted by light microscopy, were present in 14 of 18 SCAA brains and in 7 of 21 MCAA brains (P = 0.01, two‐tailed Fisher's exact test). The average number of old microinfarcts across geographic regions in each brain ranged from 0 to 1.95 (mean rank 24.94, sum of ranks 449) in the SCAA group, and from 0 to 0.35 (mean rank 15.76, sum of ranks 331) in the MCAA group (P = 0.008, two‐tailed Mann–Whitney U‐test). Frequent old microinfarcts in demented individuals with severe CAA may contribute a vascular component to the cognitive impairment in these patients.
Pengaruh Web E-Commerce, Kualitas Produk dan Kualitas Layanan terhadap Kepuasan Konsumen

This research analyzes the influence of e-commerce website, product quality and service quality to customer satisfaction. In every business entity engaged in services, especially e-commerce online is very important to pay attention to the quality of products and services, because it is directly related to the satisfaction felt by the customer who then arise the loyalty of consumers who use these services. The influence of product and service quality to the customer is said to be very important because the good quality of the products and services offered will affect the trust and the customer's loyalty. This can be seen from the result of research showing the influence of e-commerce web, product quality and service to customer satisfaction.
Abuse of Prescription Medicines in Southwestern France

BACKGROUND: Few quantitative data are available concerning abuse of medicine in the general population, although dependence on prescription medicines involves a significant proportion of the population. Falsified prescription forms can be used as an indicator of abuse. METHODS: Community pharmacists in a representative network were asked to report any falsified prescription form presented over a 1-year period. Sales data were used to express results as abuse rate and abuse rate ratio. RESULTS: Two-thirds of the 130 pharmacies in the network reported at least 1 falsified prescription. The reported incidence of falsified prescriptions was 2.3 per 10 000 inhabitants. A total of 392 falsified prescription forms was collected. The abuse rate ratios were 171 (95% CI 140 to 210) for dextroamphetamine–phenobarbital in combination, 168 (95% CI 131 to 216) for fenozolone, 67 (95% CI 53 to 84) for buprenorphine, and 40.5 (95% CI 33 to 50) for clobenzorex. CONCLUSIONS: These results show the efficiency of a method for detecting falsified prescriptions forms using community pharmacists. The abuse of medicines already known for their addictive potential can be estimated and alerts can also be detected.
Neuroimaging-detected late transient treatment-induced lesions in pediatric patients with brain tumors.

OBJECT After the resection of brain tumors in pediatric patients, it can be difficult to differentiate recurrent tumor from treatment effects. Although late-delayed reactions are thought to be permanent, in this study the authors sought to characterize transient brain lesions (TBLs) in the late-delayed period that completely resolved without imaging or neurological sequelae. METHODS In a retrospective review of an institutional neuroimaging brain tumor database, 11 patients were identified who met the imaging criteria (transient T2-weighted hyperintense enhancing lesions outside of the tumor bed, which occurred after radiation and/or chemotherapy) and had undergone three-dimensional dosimetry; their radiographic, clinical, and radiation-dosimetry results were analyzed. In the 11 patients who had been treated with multiple protocols 17 loci of abnormality, including 43 discrete, asymptomatic TBLs, were detected. The median TBL diameter was 1 cm or smaller, without mass effect or necrosis, and occurred 10 months after radiation therapy, 11 months after chemotherapy, resolved by 3 months, and occurred within the high-dose radiation treatment volume (median 55.8 Gy). The findings from extended follow up revealed the development of additional permanent complications of radiation therapy within the radiation port in five of the 11 patients. CONCLUSIONS A benign form of treatment-induced brain injury in children, TBLs should be treated using short-interval follow up. When these lesions are identified as a result of their characteristic imaging features, location, and temporal course, TBLs may be clearly distinguished from recurrent tumor or radiation necrosis and do not require biopsy. Further studies are needed to determine whether patients with TBLs are at an increased risk of developing more severe treatment-related brain injury.
Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops

Aim To demonstrate the efficacy of Rho-associated kinase (ROCK) inhibitor Y-27632 for corneal endothelial wound healing both in in vitro and in vivo models. Methods As an in vitro model, cultivated cynomolgus monkey corneal endothelial cells were scraped to create a linear defect. The wound distance was then determined during a 24-h culture in the presence or absence of 10 μM of Y-27632. As an in vivo model, central corneal endothelium of Japanese white rabbits was damaged by transcorneal freezing, then 10 mM of Y-27632 was applied topically six times daily for 48 h. The wound area of the corneal endothelium was evaluated after 48 h. Results The mean wound distance in the cultured corneal endothelial cells was significantly shorter in the Y-27632 group than in the control group. In the rabbit model, the mean wound area of the Y-27632 group was significantly smaller than that of the control group. Conclusion This study demonstrated that ROCK inhibitor Y-27632 promotes corneal endothelial wound healing both in in vitro and in vivo.
The Potential of MLN3651 in Combination with Selumetinib as a Treatment for Merlin-Deficient Meningioma

Meningioma is the most common primary intracranial tumour, and surgical resection is the main therapeutic option. Merlin is a tumour suppressor protein that is frequently mutated in meningioma. The activity of the E3 ubiquitin ligase complex, CRL4-DCAF1, and the Raf/MEK/ERK scaffold protein Kinase suppressor of Ras 1 (KSR1) are upregulated in Merlin-deficient tumours, which drives tumour growth. Identifying small molecules that inhibit these key pathways may provide an effective treatment option for patients with meningioma. We used meningioma tissue and primary cells derived from meningioma tumours to investigate the expression of DDB1 and Cullin 4-associated factor 1 (DCAF1) and KSR1, and confirmed these proteins were overexpressed. We then used primary cells to assess the therapeutic potential of MLN3651, a neddylation inhibitor which impacts the activity of the CRL family of E3 ubiquitin ligases and the MAPK/ERK kinase (MEK1/2) inhibitor selumetinib. MLN3651 treatment reduced proliferation and activated apoptosis, whilst increasing Raf/MEK/ERK pathway activation. The combination of MLN3651 and the MEK1/2 inhibitor selumetinib prevented the increase in Raf/MEK/ERK activity, and had an additive effect compared with either treatment alone. Therefore, the combined targeting of CRL4-DCAF1 and Raf/MEK/ERK activity represents an attractive novel strategy in the treatment of Merlin-deficient meningioma.
Autism following a history of newborn encephalopathy: more than a coincidence?

Between June 1993 and December 1996, 276 term newborn infants with encephalopathy and 564 randomly selected term controls were enrolled in a population‐based study of moderate and severe term newborn encephalopathy (NE) in Western Australia. During comprehensive neurobehavioural and cognitive follow‐up of all patients and controls at 3 years and again at 5 years of age we found an unexpected but strong association between NE and autism spectrum disorders (ASDs). A diagnosis of ASD by age 5 years was reached using criteria according of the Diagnostic Statistical Manual, 4th edition. Linking records to the Western Australian Disability Services Commission Register ensured that no child in the study with ASD was missed. By age 5 years, 37 (13.4%) infants with NE and one (0.2%) control had died. Among the 239 survivors of NE, 12 (5%) were diagnosed with an ASD. Of these, 10 (4.2%) met the full criteria for autism, one had pervasive developmental disorder‐not otherwise specified, and one had Asperger syndrome. Among the 563 surviving controls, five (0.8%) were diagnosed with an ASD: three with autism, one with autism/possible Asperger syndrome, and one with Asperger syndrome. Compared with the controls, the children who had experienced NE were 5.9 times (95% confidence interval 2.0–16.9) more likely to have been diagnosed with an ASD.
Types of Intellectual Capital Employed in Bioeconomic Projects  A Longitudinal Case Study

In this paper we investigate the existence and evolution of bioeconomic projects of OMV Group, a major global player in the oil and gas industry. We further study the intellectual capital components utilized by OMV Group in supporting these bioeconomic actions. We conduct a longitudinal case study over the 2010-2016 period and illustrate with the case of OMV Group how the oil and gas organizations mobilize various types of intellectual capital to engage in bioeconomic projects. Since the global importance of bioeconomy increased exponentially in the last years, we employ a theoretical framework recently proposed in the bioeconomic literature to ascertain the type of vision followed in the bioeconomic projects and its evolution. We find that the number of bioeconomic projects proposed by our case organization increased over time, and that the projects’ focus evolved from bio-technology and bio-resources to bio-ecology, which has the potential of providing more long-term sustainable outcomes.
Factors influencing mobile banking continuous use in Sub-Sahara Africa

The ubiquitous diffusion of information and communications technology is fundamentally impacting several sectors. In the financial services sub-sector, the convenience and speed with which mobile banking (m-banking) applications offer users have made it one of the most popular applications in use. However, the growth trajectory of the application is questionably different as it has continually seen a decline in the Nigerian market. The aim of this study is therefore to examine the factors influencing m-banking continuous use in an emerging market context by using a hybrid of unified theory of acceptance and use of technology (UTAUT2), uses and gratification and privacy theories. Survey data were collected from 245 m-banking users in Nigeria. Using structural equation modelling for analysis, the study found that enabling environment is a critical determinant of continuous use. Contrary to some extant studies, we found that the role of social influence is a critical determinant of continuous use, just as embedding hedonic features engenders interactivity. Recommendations are offered.
A Framework for Analysing Differences between Public-Sector and Other-Sector Projects

Objectives: The purpose of this paper is to create a model of public-sector and other-sector projects. Research Design & Methods: An extensive review of literature was performed. The snowball approach was applied for collecting relevant papers. Models of differences between public-sector organisations and other organisations were chosen as the reference models for building a model for project level. Findings: There are differences between managerial processes between public-sector and other-sector projects in all project management areas (integration management, scope management, cost management, schedule management, quality management, hr management, communications management, risk management, procurement management, and stakeholder management). Hence the most adequate model for explaining these differences is the dimensional model. Implications / Recommendations: Project managers will be able to better align their managerial methods to the sector in which project are implemented. For instance, in public-sector projects in the area of HR management motivation should be more focused on non-financial factors. Contribution / Value Added: The proposed model is the first, original, comprehensive model describing the differences between public-sector and other-sector projects. (original abstract)
Effects of palmitic and stearic acids supplementation on milk yield, composition and milk lipolysis in dairy cows

When facing the fact that high yielding dairy cows has an increasing energy requirements, the practice of adding lipid supplements such as concentrates rich in palm oil and/or palm oil industry by-products become more common. Palm oil containing high levels of C16:0 causes high levels of free fatty acids (FFA) which are linked to larger milk fat globules (MFG) which affect the reaction of lipolysis resulting in rancid flavour and processing problems. Instead of using palm oil, rapeseed oil rich in C18:1 C18:2 can be used. In order to evaluate the effect of added C18:0 and C16:0 on milk lipolysis, 30 Swedish Red lactating dairy cows including 15 multiparous (MP) and 15 primiparous (PP) cows were randomly divided in three groups resulting in 3 10 cow-groups (5 PP and 5 MP cows per group) and fed one out of three concentrate mixtures: control (C), a standard concentrate mixture with no fat added; palmitate (P) as C plus the addition of palmitate methyl ester (10 % in DM basis); and stearate (St) as C plus the addition of stearate methyl ester (10 % in DM basis). Milk yield was registered, and milk samples were collected and analysed for milk composition, FFA content and size of MFG. In addition, feed intake and in vivo digestibility were estimated. Results from the experiment showed no treatment effect on feed intake or in vivo digestibility. Changes in milk yield and composition were more evident in MP than in PP cows. The inclusion of C16:0 and C18:0 caused an increase in milk yield and milk fat content and yield, with changes being greater for cows supplemented with C18:0. The high fat treatments resulted in higher levels of FFA in milk associated with an increased size of the milk fat globules. While the results of the present study would support the concept that C16:0 may be replaced by C18:0 in treatment for dairy cows without any detrimental effect on milk yield and composition, further conclusions cannot be drawn without the data on FA profile in milk.
Evaluation of the ability of a photocoagulator to rupture the retinal vein and Bruch's membrane for potential vein bypass in retinal vein occlusion.

BACKGROUND AND OBJECTIVE To evaluate the laser power required to rupture both the retinal vein and Bruch's membrane in a porcine model using a new laser system for treatment of retinal vein occlusion. MATERIALS AND METHODS The retina was treated in areas with and without an overlying vein. Sections through the laser sites were stained for light and transmission electron microscopy. The percentage of the laser sites with rupture of the retinal vein and Bruch's membrane, the degree of tissue damage, and the diameter of the rupture in Bruch's membrane were determined. RESULTS The rate of vein rupture was 75% at 3 W, and rupture of Bruch's membrane was achieved at all powers tested. The mean diameter of the rupture in Bruch's membrane increased with laser power. CONCLUSION The Integre Duo laser system (Ellex Medical Lasers, Adelaide, Australia) is capable of rupturing the retinal vein and Bruch's membrane at lower powers than prior laser systems.
Body Surface Laplacian Mapping in Patients with Left or Right Ventricular Bundle Branch Block

Body surface Laplacian maps (BSLMs) have been previously reported to provide enhanced capability in localizing and resolving multiple spatially separate myocardial events. However, only a few studies have been reported on the clinical applications of BSLM. To test the clinical utility of BSLMs, BSLMs and body surface potential maps (BSPMs) during ventricular depolarization for complete right or left ventricular bundle branch block (CRBBB or CLBBB) were studied in ten patients in each group. As a control group, ten healthy subjects were also studied using the same procedure. One hundred and twenty‐eight electrodes were placed uniformly over the entire chest and back of the subjects. BSLMs were computed from recorded potentials, using a numerical algorithm. The BSLMs showed multiple and more localized positive and negative activities compared with the BSPMs. In healthy subjects, the BSLMs showed multiple areas of positive activity overlying the RV, LV, and the RV outflow, and negative activity corresponding to RV free‐wall breakthrough and LV anterolateral breakthrough sites, whereas the BSPMs could not separate RV and LV activities. In the patients with CRRRR, the BSLMs showed more localized areas of activity corresponding to the LV apex breakthrough and LV lateral breakthrough, and separated LV lateral and posterior activation. In the patients with CLBBB, the BSLMs showed multiple RV activation, and propagating activation of LV from lateral to posterior. The BSLMs appear to provide enhanced capability in detecting multiple ventricular electrical events associated with normal and abnormal conduction and a more detailed activation sequence of both ventricles in healthy subjects and in the patients with CRBBB and CLBBB. BSLM may provide an important alternative to other imaging modalities in localizing cardiac electrical activity noninvasively.
Leadership And Sustainability In Public Field

In this paper I have approached issues related to the need for leadership in the public sector, which is considered to be one of the most important elements contributing to the success or failure of organisations and hence, to the sustainable development of organisations in the public sector. Leadership can be seen as a system, as a process, as a method or as a cultural state that is based on a cultural process of transformation, starting with each and every person within the organisation, continuing with the team and the organisation and, finally, with the transformation of the entire society. The fundamental objective of the paper was to highlight the essence of the leadership concept in this field and to capture the relationship between sustainable leadership and sustainable development of the organisations. Based on the research and analysis of the specialized literature in studies, articles, books, I have developed a model of sustainable leadership that can contribute to transformational change, thus, responding to the specific challenges of the public sector and also, to the global changes that have become critical.
Complications after percutaneous saline-enhanced radiofrequency ablation of liver tumors: 3-year experience with 336 patients at a single center.

OBJECTIVE Our objective was to report the complications that occurred in a large series of patients with primary or metastatic liver tumors treated with percutaneous saline-enhanced radiofrequency ablation under sonographic guidance at a single center during 3 years of experience. SUBJECTS AND METHODS Between September 2000 and October 2003, 336 consecutive patients (221 men and 115 women; age range, 44-78 years; mean, 67 years) with 407 malignant liver tumors were treated at our institution using radiofrequency ablation. Of these patients, 287 had hepatocellular carcinoma from cirrhosis, 47 had liver metastases (38 from colon, six from breast, two from lung, and one from cutaneous melanoma), and two had primary cholangiocarcinoma. Adverse events related to radiofrequency ablation were prospectively recorded. RESULTS The number of sessions performed was 375 (39 patients had two sessions). The number of patients with major complications, including death, was three (0.9%). The overall mortality rate was 0.3% (1/336). One patient died because of worsening liver decompensation. Two other major complications occurred. In one patient (0.3%), liver abscess and sepsis developed and were successfully treated with percutaneous sonography-guided needle (18-gauge) aspiration and IV antibiotics. Mild posttreatment ascites occurred in one patient (0.3%). One patient showed self-limiting subcutaneous cellulitis along the electrode-needle path that healed in 2 weeks. Fever lasting 1-3 days and pain lasting 12-24 hr were observed in 141 patients (42%) and 211 patients (63%), respectively. So far, no cutaneous or abdominal wall seeding has been observed clinically or sonographically. CONCLUSION Radiofrequency ablation of liver tumors can be considered safe. Life-threatening acute liver failure can be considered a rare possible complication.
Signals for 2°C: the influence of policies, market factors and civil society actions on investment decisions for green infrastructure

ABSTRACT The targets of the Paris Agreement make it necessary to redirect finance flows towards sustainable, low-carbon infrastructures and technologies. Currently, the potential of institutional investors to help finance this transition is widely discussed. Thus, this paper takes a closer look at influence factors for green investment decisions of large European insurance companies. With a mix of qualitative and quantitative methods, the importance of policy, market and civil society signals is evaluated. In summary, respondents favor measures that promote green investment, such as feed-in tariffs or adjustments of capital charges for green assets, over ones that make carbon-intensive investments less attractive, such as the phase-out of fossil fuel subsidies or a carbon price. While investors currently see a low impact of the carbon price, they rank a substantial reform as an important signal for the future. Respondents also emphasize that policy signals have to be coherent and credible to coordinate expectations.
Analysis of Reinforcing Factor with Involvement of Informal Sector Workers in Occupational Health Post (Pos UKK)

Background: Occupational Health Post (Pos UKK) is a program aims to improve occupational health and productivity of informal sector workers in Indonesia through promotive, preventive, simple curative and rehabilitative care with the principle of Community Based Health Efforts (UKBM). The number of Pos UKK registered in Semarang City Health Office is 30 units. The results of the preliminary study illustrate different situations because there were only 6 Pos UKK. Among those, only 2 were active (6.7%) from the registered Pos UKK. It’s alleged that inactivity of Pos UKK due to low support from various parties and impacted on low sustainability of the program. This study aims to analyze the reinforcing factor with the involvement of informal sector workers in Pos UKK in Semarang City.Methods : Quantitative study with cross sectional approach. Population were 146 workers and selected sample were 70 workers. Independent variables include co-worker support, business owner support and Community Health Centre (Puskesmas) support and dependent variable is involvement of informal sector workers in Pos UKK.Results : Majority of informal sector workers involvement in Pos UKK were low (51,43%). Co-worker and business owners support was good but Puskesmas support as guide was not. Statistically, co-worker support (p = 0,000, OR = 30.8), business owner support (p <0.001, OR = 10.6) and Puskesmas support (p <0.001, OR = 13.5) proved to have a significant relationship. Conclusion:This study showed that reinforcing factors have significant relationship in increasing involvement of informal sector workers in Pos UKK to ensure program sustainability. Puskesmas is expected to provide continuing assistance and socialization about the benefits of Pos UKK to informal sector workers.