Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of hydrophilic or lipophilic emulsions containing Echinacea purpurea extract in treatment of different types of pruritus

Background Pruritus reduces quality of life and may occur at different sites of the body. To alleviate pruritus, lipid replenishing and rehydration of the skin is often unsatisfactory. Thus, products with additional antipruritic effects are needed. Objectives Antipruritic effects and cosmetic properties of two different emulsions, water-in-oil (w/o) or oil-in-water (o/w), and a shampoo containing a lipophilic Echinacea purpurea root extract (Ec.-extract) were assessed in adults suffering from pruritus. Methods Adults (n = 55) with pruritus of the body applied a w/o emulsion for 2 weeks. In a separate study, adults (n = 33) with a pruritic scalp applied an o/w-emulsion for 4 weeks. In a third study, shampoo (n = 34) was applied for 4 weeks. Objective (erythema, dryness, and papules) and subjective (intensity, duration, and burden of pruritus) parameters were assessed. Results Treatment with the w/o emulsion significantly reduced erythema and dryness (P < 0.0001) as well as pruritus (in 93% of participants) on the body. Treatment with the o/w-emulsion on the scalp significantly (P < 0.0001) reduced objective (erythema in 61% and dryness in 85% of participants) and subjective (85% of participants had reduced pruritus) parameters. Similar results in reduction of dryness (76% of participants) and pruritus (70 % of participants) were seen after 4 weeks of shampoo use. Conclusion Independent from the type of emulsion (w/o or o/w), cosmetic products containing a proprietary Ec. -extract significantly reduced objective and subjective parameters in adults suffering from acute or chronic pruritus exhibiting excellent tolerability.
Epidemiology of Early-onset Bacterial Neonatal Infections in Madagascar

Background: Little is known about early-onset neonatal bacterial infections (EONBI) in Madagascar. Our aim was to determine their epidemiology to improve their management. Methods: Inborn neonates at risk for EONBI and admitted in the neonatal unit of 2 tertiary hospitals in Antananarivo, Madagascar, were included in a prospective study from April 2012 to March 2013. Using a clinical algorithm, blood culture, gastric fluid culture and C-reactive protein dosage were performed in newborns at high risk of infection, that is, peri partum fever, prematurity <35 weeks’ gestation or birth weight <2000 g, or presenting with clinical signs of infection. EONBI was defined as a bacteremia occurring within the first week of life. Results: Among 307 neonates, 75 (24.4%) had an EONBI caused by 1 (n = 59) or 2 (n = 16) bacteria (91 isolates). Gram-negative bacteria were predominant (n = 62, 82.7%), including Enterobacter cloacae (n = 26), Klebsiella pneumoniae (n = 14), Escherichia coli (n = 7) and Proteus mirabilis (n = 2). Group B Streptococcus, Acinetobacter baumanii and Enterococcus sp. represented 3.6%, 8.2% and 12.1% of the isolates, respectively. All E. cloacae and 12/14 (85.7%) K. pneumoniae were extended-spectrum &bgr;-lactamase producers. At all, 41/91 (45.1%) bacteria were multidrug-resistant (MDR) and 34/75 (45.3%) newborns had an EONBI caused by an MDR bacteria. Neonatal asphyxia was the only factor associated with multidrug resistance (odds ratio: 4.52; CI: 1.20–16.94; P = 0.025). The EONBI-related mortality (n = 20/75, 26.7%) rose up to 38.2% (n = 13/34) in case of MDR bacteria. Conclusions: The epidemiology of EONBIs in Madagascar is comparable to that found in many low-income countries. Prevention, including improvement of hygiene during resuscitation for neonatal asphyxia, is likely to be more effective in reducing EONBI-related morbidity and mortality than using new antibiotics to counter resistance.
Factors associated with family, school and behavioral characteristics on sexual initiation: A gender analysis for Brazilian adolescents

Adolescence is a period of transition between childhood and adulthood. The article aims to study the individual, family and school characteristics of adolescents beginning their sexual lives. The database we used was the 2015 PeNSE (National Adolescent School-based Health Survey) and the methodology was the survival analysis. The results show that boys initiate sexual activity before girls and risky behaviors associated with the use of licit and illicit drugs increase the chance of having early sex. In addition, this work highlights the importance of parental practices in reducing the chances of beginning sexual activity, as well as the presence of school workshops on the risks of pregnancy. It should be noted that intervention strategies need to be differentiated according to gender in order to increase effectiveness.
Pupil Size as a Gateway Into Conscious Interpretation of Brightness

Although retinal illumination is the main determinant of pupil size, evidence indicates that extra-retinal factors, including attention and contextual information, also modulate the pupillary response. For example, stimuli that evoke the idea of brightness (e.g., pictures of the sun) induce pupillary constriction compared to control stimuli of matched luminance. Is conscious appraisal of these stimuli necessary for the pupillary constriction to occur? Participants' pupil diameter was recorded while sun pictures and their phase-scrambled versions were shown to the left eye. A stream of Mondrian patterns was displayed to the right eye to produce continuous flash suppression, which rendered the left-eye stimuli invisible on some trials. Results revealed that when participants were aware of the sun pictures their pupils constricted relative to the control stimuli. This was not the case when the pictures were successfully suppressed from awareness, demonstrating that pupil size is highly sensitive to the contents of consciousness.
Essential newborn care practice and its predictors among mother who delivered within the past six months in Chencha District, Southern Ethiopia, 2017

Introduction Components of essential newborn care and neonatal resuscitation are proven interventions for reducing neonatal mortality rate and stillbirth rates. Various studies have been conducted, but they failed in assessing health workers that delivered essential newborn care, facets of the health care system, and different traditional beliefs. As such, the primary aim of this study is to fill the gaps of the aforementioned previous studies, assess mothers’ current practice of essential newborn care and identify factors affecting newborn care practices in Chencha District, Southern Ethiopia. Methods A mixed type, community-based cross sectional study was conducted among 630 study participants by using one-stage cluster sampling method. Three focus group discussions (FGD) with purposively selected 18 mothers were involved for qualitative study. Data entry was carried out by Epi data version 3.1 and analysis was done by SPSS window version 22. Binary logistic regression was used to identify predictors. Qualitative data were analyzed deductively by using thematic framework analysis approach by using Open Code version 4.02. Results This study found that 38.4% of mothers had good practices in essential newborn care. Of the neonates, 52.9% received safe cord care, 71.0% received optimal thermal care and 74.8% had good neonatal feeding. Factors such as mothers receiving antenatal care, attending pregnant mothers meetings, receiving immediate postnatal care, wealth index, whether a complication was faced during delivery and overall knowledge of mothers were statistically significantly associated with practice. Conclusions This study indicated that the current rate of essential newborn care practice was low. As such, strengthening the provision of antenatal and postnatal care services, information communication education and behavioral change communications on essential newborn care are recommended.
Multimodal magnetic resonance imaging investigation of basal forebrain damage and cognitive deficits in Parkinson's disease

Cognitive deficits in Parkinson's disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1‐2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4).
Management and treatment of the HCV‐infected kidney transplant patient

The prevalence of hepatitis C virus infection is increased in patients with end stage kidney disease compared to the general population and is an adverse outcome determinant. Direct‐acting antiviral therapy for hepatitis C virus is changing the management paradigm of infected kidney transplant candidates and recipients, with potential to reduce patient morbidity and mortality. This review describes the hepatic and nonhepatic manifestations of hepatitis C virus in kidney transplant patients as well as management and treatment strategies to optimize transplant outcomes, highlighting the importance of direct‐acting antivirals in this population.
Developmental regulation of an organelle tether coordinates mitochondrial remodeling in meiosis

Cellular differentiation involves remodeling cellular architecture to transform one cell type to another. By investigating mitochondrial dynamics during meiotic differentiation in budding yeast, we sought to understand how organelle morphogenesis is developmentally controlled in a system where regulators of differentiation as well as organelle architecture are known, but the interface between them remains unexplored. We found that mitochondria abruptly detach from the cell cortex shortly before segregating into gametes. Mitochondrial detachment is enabled by the programmed destruction of the mitochondria-endoplasmic reticulum-cortex anchor (MECA), an organelle tether that forms contact sites between mitochondria and the plasma membrane. MECA regulation is governed by a meiotic transcription factor, Ndt80, which promotes the activation of a conserved kinase, Ime2. We found that MECA undergoes Ime2-dependent phosphorylation. Furthermore, Ime2 promotes MECA degradation in a temporally controlled manner. Our study defines a key mechanism that coordinates mitochondrial morphogenesis with the landmark events of meiosis and demonstrates that cells can developmentally regulate tethering to induce organelle remodeling.
Evolution of Functional Bacteria in a Polycyclic Aromatic Hydrocarbon (PAH)‐Degrading Bioreactor

In this study a laboratory‐scale sequencing batch bioreactor was constructed, using phenanthrene/pyrene as the sole carbon‐source, to demonstrate the removal efficiencies of polycyclic aromatic hydrocarbons (PAHs) and the evolution process of a functional bacterial community. The removal rates were: COD, 51.4 to 76.3%; phenanthrene, 63.5 to 92.4%; and pyrene, 65.9 to 90.1%. Quantification analysis indicated that in sludge samples from the phenanthrene/pyrene degradation stage, the contents of 16S rRNA and ring‐hydroxylating dioxygenase genes of Gram‐positive and Gram‐negative bacteria were 10‐and 72‐, 102‐ and 1152‐, 31‐ and 905‐fold higher, respectively, than those in seed sludge samples. Clone sequencing and evolution analysis showed that genera Comamonas, Pseudomonas, and Mycobacterium were distributed across all samples and were significant PAH‐degrading populations, but some genera, such as Polaromonas and Nocardioides, were substantially enriched only when phenanthrene/pyrene was fed. Correspondingly, the functional genes nidA3, phnAc, and ndoC2 were distributed across all samples, whereas nagAc, pdoA2, and pdoA were enriched only when phenanthrene/pyrene was fed.
Physical exercise and non‐insulin glucose‐lowering therapies in the management of Type 2 diabetes mellitus: a clinical review

In the UK the National Institute of Health and Care Excellence (NICE) advocates intensive lifestyle programmes that attain the levels of daily physical activity set out by the Chief Medical Officer as a first‐line strategy for improving the health of people at risk of developing diabetes or reducing the risk of development of Type 2 diabetes. For people with Type 2 diabetes, lifestyle measures complement pharmacological treatments that include both oral and injectable therapies. In line with this, NICE guidelines also support intensification of efforts to improve patient lifestyle along with these glucose‐lowering therapies. There is a paucity of evidence, however, in the available published literature examining the association between glucose‐lowering therapies and exercise metabolism. In the present review we explore the current knowledge with regard to the potential interactions of oral and non‐insulin injectable therapies with physical activity in people at risk of, or who have, Type 2 diabetes, and present evidence that may inform healthcare professionals of the need to monitor patients more closely in their adaptation to both pharmacological therapy and physical activity.
Antibiotic resistance of Campylobacter jejuni isolates recovered from humans with diarrhoea in Turkey

Purpose. This study was aimed at investigating the occurrence and genetic mechanisms of resistance to ciprofloxacin, tetracycline and erythromycin in clinical isolates of Campylobacter jejuni recovered from human cases of acute gastroenteritis in Turkey. Methodology. MIC values of each antibiotic were determined with the epsilometer test (E‐test). Resistance genes/mutations were first screened by PCR and analysed by subsequent DNA sequencing. Results. From a total of 152 C. jejuni isolates tested, 113 (74.3%), 38 (25%) and 9 (5.9%) were found to be resistant to ciprofloxacin, tetracycline and erythromycin, respectively. Sequence analysis of ciprofloxacin‐resistant isolates showed that all resistant strains (n=113) carried Thr‐86‐Ile substition in the gyrA gene, which is the most frequently observed mutation in fluoroquinolone‐resistant Campylobacter. All of the tetracycline‐resistant isolates (n=38) carried the tetO gene. All of the erythromycin‐resistant isolates (n=9) harboured the point mutation A2075G in the 23S rRNA gene, which is the most common mutation conferring macrolide resistance in C. jejuni. Conclusion. The phenotypic susceptibility testing results were found to agree well with those obtained by genetic detection methods for the C. jejuni isolates tested. The findings of this study showed a very high level of resistance to ciprofloxacin and to a lesser extent to tetracycline while resistance to erythromycin remained at a low level. Thus, erythromycin may be considered as the first choice for treatment of Campylobacter infections in this geographical region when indicated.
Safety and efficacy of the rSh28GST urinary schistosomiasis vaccine: A phase 3 randomized, controlled trial in Senegalese children

Background Urinary schistosomiasis, the result of infection by Schistosoma haematobium (Sh), remains a major global health concern. A schistosome vaccine could represent a breakthrough in schistosomiasis control strategies, which are presently based on treatment with praziquantel (PZQ). We report the safety and efficacy of the vaccine candidate recombinant 28-kDa glutathione S-transferase of Sh (rSh28GST) designated as Bilhvax, in a phase 3 trial conducted in Senegal. Methods and findings After clearance of their ongoing schistosomiasis infection with two doses of PZQ, 250 children aged 6–9 years were randomized to receive three subcutaneous injections of either rSh28GST/Alhydrogel (Bilhvax group) or Alhydrogel alone (control group) at week 0 (W0), W4, and W8 and then a booster at W52 (one year after the first injection). PZQ treatment was given at W44, according to previous phase 2 results. The primary endpoint of the analysis was efficacy, evaluated as a delay of recurrence of urinary schistosomiasis, defined by a microhematuria associated with at least one living Sh egg in urine from baseline to W152. During the 152-week follow-up period, there was no difference between study arms in the incidence of serious adverse events. The median follow-up time for subjects without recurrence was 22.9 months for the Bilhvax group and 18.8 months for the control group (log-rank p = 0.27). At W152, 108 children had experienced at least one recurrence in the Bilhvax group versus 112 in the control group. Specific immunoglobulin (Ig)G1, IgG2, and IgG4, but not IgG3 or IgA titers, were increased in the vaccine group. Conclusions While Bilhvax was immunogenic and well tolerated by infected children, a sufficient efficacy was not reached. The lack of effect may be the result of several factors, including interference by individual PZQ treatments administered each time a child was found infected, or the chosen vaccine-injection regimen favoring blocking IgG4 rather than protective IgG3 antibodies. These observations contrasting with results obtained in experimental models will help in the design of future trials. Trial registration ClinicalTrials.gov NCT 00870649
Neural Processes Mixed-Effect Models for Deep Normative Modeling of Clinical Neuroimaging Data

Normative modeling has recently been introduced as a promising approach for modeling variation of neuroimaging measures across individuals in order to derive biomarkers of psychiatric disorders. Current implementations rely on Gaussian process regression, which provides coherent estimates of uncertainty needed for the method but also suffers from drawbacks including poor scaling to large datasets and a reliance on fixed parametric kernels. In this paper, we propose a deep normative modeling framework based on neural processes (NPs) to solve these problems. To achieve this, we define a stochastic process formulation for mixed-effect models and show how NPs can be adopted for spatially structured mixed-effect modeling of neuroimaging data. This enables us to learn optimal feature representations and covariance structure for the random-effect and noise via global latent variables. In this scheme, predictive uncertainty can be approximated by sampling from the distribution of these global latent variables. On a publicly available clinical fMRI dataset, we compare the novelty detection performance of multivariate normative models estimated by the proposed NP approach to a baseline multi-task Gaussian process regression approach and show substantial improvements for certain diagnostic problems.
Quantitative Proteomics by SWATH‐MS Suggest an Association Between Circulating Exosomes and Maternal Metabolic Changes in Gestational Diabetes Mellitus

Several factors including placental hormones (PH) released from the human placenta have been associated with the development of insulin resistance and gestational diabetes mellitus (GDM). However, circulating levels of PH does not correlate well with maternal insulin sensitivity across gestation, suggesting that other, previously unrecognized, mechanisms may be involved. The levels of circulating exosomes are higher in GDM compared to normal. GDM derived exosomes produce greater release of pro‐inflammatory cytokines from endothelial cells compared to exosomes from normal, suggesting that their contents may differ compared to normal pregnancies. Using a quantitative, information‐independent acquisition (Sequential Windowed Acquisition of All Theoretical Mass Spectra [SWATH]) approach, differentially abundant circulating exosome proteins are identified in women with normal glucose tolerance (NGT) and GDM at the time of GDM diagnosis. A total of 78 statistically significant proteins in the relative expression of exosomal proteins in GDM are compared with NGT. Bioinformatic analysis shows that the exosomal proteins in GDM target pathways are mainly associated with energy production, inflammation, and metabolism. Finally, an independent cohort of patients is used to validate some of the proteins identified by SWATH. The data obtained may be of utility in elucidating the underlying physiological mechanisms associated with insulin resistance in GDM.
EFFICACY OF REFLEXIVE NEUROMUSCULAR STABILIZATION DURING TREATMENT OF SCAPULAR DYSKINESIA IN AN OVERHEAD ATHLETE: A CASE REPORT.

Background and Purpose Shoulder injuries are common amongst overhead athletes. Dysfunctional motor patterns (scapular dyskinesis) may be the cause or result. Improperly treated, they can sideline athletes or reduce quality of life. Current treatment protocols are lengthy and may result in recurrence. Individualization of treatment is key. Functional tests, like the Selective Functional Movement Assessment (SFMA), help discern and properly identify dysfunction, paving the way for interventions like reflexive neuromuscular stabilization (RNS). RNS focuses on restoring proper motor control and may positively influence healing. The purpose of this case report is to describe an evaluation and treatment strategy for scapular dysfunction in an overhead athlete. Case Description The subject was a 16-year-old, multi-sport athlete in the high school setting. He presented with upper back pain during his sophomore baseball season. Clinical findings upon examination included but were not limited to irregular scapular positioning as compared bilaterally, dysfunctional scapular movement patterns, soft tissue muscular irritability and loss of glenohumeral (GH) ROM in internal and external rotation, flexion and abduction. Intervention consisted of a combination of positional release therapy and reflexive neuromuscular stabilization aided by some traditional therapeutic modalities. Outcomes The combination of conservative treatments and RNS provided relief of the subject's symptoms in a shorter time frame, three treatments over the course of six days, than just utilizing traditional protocols. The utilization of the paired treatments resulted in diminished pain, restored ROM and improvement in perceived fluidity (speed and stability) of motion as observed by the clinician. A minimal clinically important difference (MCID) was reported on the disablement of the physically active scale (DPAs) on all follow-up treatments as well as on the numeric pain rating scale (NPRS) after the first and second treatments. The minimal detectable change (MDC) requirement was met on the patient specific functional scale (PSFS) prior to the second and third treatment. The activities measured with the PSFS were: GH flexion, GH abduction and throwing a baseball. Discussion In this case report, the use of the SFMA along with a traditional orthopedic examination allowed for proper identification and location of the dysfunctional motor patterns. The coupling of a traditional modality like the moist heat pack, with PRT and RNS proved to be a beneficial treatment combination for this subject as it provided a clinically meaningful resolution of his condition. Even though current literature suggests that treatment for scapular dysfunction is comprised of three phases over the course of ten weeks, clinicians should focus on the individualization of the treatment, possibly utilizing novel interventions like PRT and RNS. Level of Evidence 4 Case Report.