Miracle-dz/UniFAR-FTUs huggingface dataset:
Productions lamellaires aurignaciennes à l'est des Carpates

The lithic assemblages of Siuren I (Ukraine) suggest that two successive phases can be distinguished in the Krems-Dufour facies of the Aurignacian in eastern Europe (DEMIDENKO et al.). The assemblages of Kostenki 1 (Russia) and Mitoc-Malu Galben (Romania) do not contradict this distinction and show the functional role of the sites in the representation of lamellar products. 1 Présence aurignacienne à l’est des Carpates Les sites aurignaciens à l’est des Carpates sont rares. Trois gisements ont été identifiés comme tels et datés avec certitude : Mitoc-Malu Galben en Roumanie (Otte et Chirica 1993), Siuren I en Ukraine (Crimée) (Otte et al. 1996a ; Demidenko et al. 1998) et Kostenki 1, niveaux III-II, en Russie (Sinitsyn 1993)1 [fig. 1]. Outre les résultats 14C, l’attribution à l’Aurignacien est assurée, dans le premier cas par la présence de nombreux outils carénés (grattoirs, burins) et d’une pointe de sagaie à base massive de type Mladec, et, dans les deux autres cas, par la présence des mêmes outils carénés et de lamelles retouchées de type Dufour, parfois de pointes de Krems. Quelques autres sites peuvent être ajoutés à cette liste : Corpaci-Mâs en République Moldave, proche de Mitoc et qui a livré deux pointes osseuses de type Mladec et quelques grattoirs carénés et à museau (Borziac, Grigorieva et Chetraru 1981), Buran Kaya III en Crimée, où des lamelles retouchées similaires à celles de Siuren I (lamelles Dufour, pointes de Krems) ont été retrouvées (Yanevich 1998), et Chulek I et la grotte Kamennomostkaya en Russie, respectivement sur le cours inférieur du Don et dans le nord du Caucase, qui présentent des similarités typologiques et technologiques avec Siuren I (Demidenko 2000-2001). Siuren I et les niveaux aurignaciens de Kostenki 1 sont le plus souvent attribués au faciès Krems-Dufour de l’Aurignacien d’Europe centrale et orientale, dont les caractéristiques sont, selon Joachim Hahn, une “production accentuée de lamelles à partir de nucléus coniques ou de grattoirs carénés qui y sont généralement nombreux”, le trait distinctif étant la présence de nombreuses lamelles Dufour, avec dans quelques sites des pointes à retouche semi-abrupte directe (Hahn 1970, p. 211). Ces ensembles à lamelles Dufour peuvent être fort différents les uns des autres (Hahn 1977, p. 315 ; voir aussi Koz»owski et Koz»owski 1979 ; Demidenko et Otte 2000-2001). Le cas de Mitoc évoque l’Aurignacien typique connu dans les Balkans (à Bacho Kiro et Temnata notamment, entre 34 000 et 28 000 bp), dans lequel on trouve des exemples de pointes de sagaie à base massive de type Mladec, et qui est parallèle à l’Aurignacien II d’Europe occidentale 439 Productions lamellaires attribuées à l’Aurignacien : Chaînes opératoires et perspectives technoculturelles XIVe congrès de l‘UISPP, Liège 2-8 Septembre 2001 ArchéoLogiques 1
Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men

Objectives. Peroxisome proliferator activated receptor delta (PPARD) is a transcription factor implicated in the regulation of genes involved in cholesterol metabolism. We recently discovered a common polymorphism in the 5′‐untranslated region (5′‐UTR) of the human PPARD, +294T/C, that is associated with an increased plasma low‐density lipoprotein cholesterol (LDL‐C) concentration in healthy subjects. Whether the +294C allele is associated with LDL‐C elevation independently of the background lipoprotein phenotype and whether it confers increased risk of coronary heart disease (CHD) is unknown. Against this background, we investigated the relationships between the PPARD polymorphism and plasma lipoprotein concentrations and the risk for contracting CHD in the West of Scotland Coronary Prevention Study (WOSCOPS).
A Probabilistic Approach in Historical Linguistics Word Order Change in Infinitival Clauses: from Latin to Old French

This thesis investigates word order change in infinitival clauses from Object-Verb (OV) to VerbObject (VO) in the history of Latin and Old French. By applying a variationist approach, I view word order change as a diachronic variation, which is probabilistically influenced by internal and external language contexts. That is, I examine a synchronic word order variation in each stage of language change, from which I infer the character, periodization and constraints of diachronic variation. I also show that in discourse-configurational languages, such as Latin and Early Old French, it is possible to identify pragmatically neutral contexts by using information structure annotation, a recent method developed for historical texts. I further argue that by mapping pragmatic categories into a syntactic structure, we can detect how word order change unfolds.
The Return of the Giants: Ecological Effects of an Increasing Elephant Population

Abstract Northern Botswana and adjacent areas, have the world's largest population of African elephant (Loxodonta africana). However, a 100 years ago elephants were rare following excessive hunting. Simultaneously, ungulate populations were severely reduced by decease. The ecological effects of the reduction in large herbivores must have been substantial, but are little known. Today, however, ecosystem changes following the increase in elephant numbers cause considerable concern in Botswana. This was the background for the “BONIC” project, investigating the interactions between the increasing elephant population and other ecosystem components and processes. Results confirm that the ecosystem is changing following the increase in elephant and ungulate populations, and, presumably, developing towards a situation resembling that before the reduction of large herbivores. We see no ecological reasons to artificially change elephant numbers. There are, however, economic and social reasons to control elephants, and their range in northern Botswana may have to be artificially restricted.
Robotic surgery approach to incarcerated inguinoscrotal hernia: A case report

Introduction: Repair of inguinal hernias is one of the most common procedures performed by general surgeons today. Specifically, management of incarcerated inguinal hernias currently open tension free repair followed by laparoscopic approaches (transabdominal preperitoneal and totally extraperitoneal) is the most prevalent. More recently, the application of robotic platform da Vinci surgical system has permutated every aspect of general surgery including hernia surgery. We describe our experience with robotic approach to repair of incarcerated inguinoscrotal hernia. Case Report: We present an 81-year-old male with a threeyear history of reducible right inguinal hernia that presented to the emergency department with inability to reduce the hernia. He was subsequently diagnosed with right incarcerated inguinoscrotal hernia and recommended to undergo surgical intervention. Robotic surgical approach was chosen for repair of his hernia. patient underwent successful robotic repair with mesh of right incarcerated inguinoscrotal hernia and had an unremarkable postoperative course. Thomas J. Shaknovsky1, Lance U. Jung2, Seth Iskowitz3, Zahra Beizaeipour4 Affiliations: 1DO, Southeast Alabama Medical Center, Attending Surgeon, Dothan, AL, USA; 2MD, FACS, Richmond University Medical Center, Attending Surgeon, Staten Island, New York, USA; 3BS, Richmond University Medical Center, Medical Student, Staten Island, New York, USA; 4BSc, MS, Richmond University Medical Center, Medical Student, Staten Island, New York, USA. Corresponding Author: Thomas J, Shaknovsky; E-mail: surgery2009@icloud.com Received: 24 May 2016 Accepted: 16 December 2016 Published: 30 May 2017 Conclusion: The 3D high definition imaging and superior dissection control of the robotic platform da Vinci surgical system affords the surgeon unique advantage in approaching incarcerated inguinal hernias. Although, currently open and laparoscopic approaches are more prevalent, the robotic approach is safe and effective option.
Offering strategy of a price-maker energy storage system in day-ahead and balancing markets

Energy storage systems (ESS) are considered as a promising solution to improve power system flexibility and facilitate the integration of renewables in electricity markets. This paper investigates the impact of strategic offering by an ESS operator in the day-ahead and balancing market. The offering strategy of a price-maker ESS operator is formulated as a bilevel model, where the upper-level problem represents the profit maximization of the ESS operator and the lower-level problem simulates the market-clearing outcome. This methodological framework can be used either to assess market efficiency distortion or as a trading strategy from the perspective of the ESS operator. Our analysis shows that adopting strategic behavior may improve ESS expected profit but reduces social welfare, especially for high ESS energy-to-power ratios.
Are perivascular cells in cartilage canals chondrocytes?

Cole & Wezeman (1985) described two types of perivascular cells within superficial canals of the mouse. These cells morphologically resemble the macrophages and fibroblasts described in other canal studies (Andersen & Matthiessen, 1966; Rodriquez, Delgado & Paniagua, 1985; Chappard, Alexandre & Riffat, 1986) and at other sites of uncalcified cartilage matrix degradation (Sorrell & Weiss, 1980; Bromley & Woolley, 1984; Muhlhauser, 1986). In a subsequent cytochemical study (Cole & Wezeman, 1987), the macrophage-like cell was neither acid phosphatasenor nonspecific esterase-positive, placing doubt on its identity as a macrophage. The present study reassesses the lineage of the perivascular cells in the superficial canals using the cartilage-specific interlacunar network (Belanger & Migicovsky, 1961; Cole 1982b, 1984a, b) and re-evaluates the ultrastructure of the two cell types in the superficial canals. Both mice and rats were used in the study since the stages of canal development have been defined in the mouse (Cole & Wezeman, 1985) while the interlacunar network has been most extensively studied in the rat (Cole, 1982b; 1984a, b).
A Little Bit of Dalba Goes a Long Way: Dalbavancin Use in a Vulnerable Patient Population

Abstract Background Serious staphylococcal infections require prolonged courses of intravenous (IV) antibiotics. Weekly IV dalbavancin is an alternative to more frequent IV antimicrobial dosing for homeless patients or persons who inject drugs (PWID), for whom creating a treatment plan can be challenging. We examined the clinical outcomes in patients who were treated with dalbavancin compared with a similar population treated with alternative antibiotics. Methods We identified 18 patients who received dalbavancin from June 1, 2015 to December 31, 2016 using pharmacy records and 89 patients receiving IV antibiotics for similar infections treated at Harborview Medical Center from January 1, 2015 to May 31, 2015, before dalbavancin was available. Medical records were reviewed, and patient demographics, length of stay (LOS), readmission, and outcomes were abstracted using REDCap, linked to the University of Washington’s Clinical Data Repository. Results Basic demographics in Table 1. The types of infections are in Figure 1. Clinical cure rates were similar between the two groups (Figure 2) although 21% and 28% of the patients were lost to follow-up in the pre and post dalbavancin period. Among the subgroup of PWID, those who received dalbavancin had higher rates of clinical cure (64.7% vs. 29.4%, P = 0.01), a trend toward decreased LOS (11.4 ± 5.8 vs. 20.2 ± 15.1 days, P = 0.04), and fewer 30-day readmissions (0% vs. 29.4%, P = 0.02) (Figure 2). Fewer PWID in the dalbavancin group were lost to follow-up (23.5% vs. 70.6%). Conclusion Patients treated with dalbavancin had similar outcomes compared with patients treated in the pre-dalbavancin time period. Among PWID, dalbavancin use led to significantly improved outcomes including a higher clinical cure rate, lower readmission rate, and shorter hospital LOS, which offset the cost of the drug. Dalbavancin is an option for the treatment of serious staphylococcal infections in selected patients. Table 1: Baseline Characteristics Entire Population PWID Population Pre-Dalbavancin N = 89 (%) Dalbavancin N = 18 (%) Pre-Dalbavancin N = 17 (%) Dalbavancin N = 17 (%) Mean Age in years 51 37 37 36 Male 64 (71.9) 15 (83.3) 12 (70.6) 14 (82.4) Homeless 18 (20.2) 8 (44.4) 9 (52.9) 7 (41.2) IDU 17 (19.1) 17 (94.4) 17 (100) 17 (100) Abbreviations: IDU= injection drug use. Disclosures All authors: No reported disclosures.
Dynamic analysis of dark-light changes of the anterior chamber angle with anterior segment OCT.

PURPOSE To describe the use of anterior segment optical coherence tomography (OCT) in studying the dynamic dark-light changes of the anterior chamber angle. METHODS Thirty-seven normal subjects with open angles on dark-room gonioscopy and 18 subjects with narrow angles were analyzed. The dynamic dark-light changes of the anterior-chamber angle were captured with real-time video recording. The angle opening distance (AOD500) and trabecular iris space area (TISA500) of the nasal angle and the pupil diameter in each of the representative serial images were measured. Linear regression analysis was performed to investigate the association between AOD500/TISA500 and pupil diameter. Demographic and biometry measurements associated with the AOD difference (AOD500((light)) - AOD500((dark))) and TISA difference (TISA500((light)) - TISA500((dark))) were analyzed with univariate and multivariate regression models. RESULTS The AOD500/TISA500 measured in the light in the open-angle and the narrow-angle groups were 694 +/- 330 microm/0.24 +/- 0.10 mm(2) and 265 +/- 78 microm/0.10 +/- 0.03 mm(2), respectively. These values were significantly greater than the AOD500/TISA500 measured in the dark (492 +/- 265 microm/0.16 +/- 0.08 mm(2) and 119 +/- 82 microm/0.05 +/- 0.04 mm(2), respectively, all with P < 0.001). The ranges of the AOD/TISA difference were 13 to 817 microm/0.011 to 0.154 mm(2), with an average of 180 microm/0.073 mm(2). Multivariate regression analysis identified a positive correlation between anterior chamber depth and the AOD/TISA difference. Fifty eyes showed significant correlations between AOD/TISA and pupil diameter, whereas one eye showed no association. Four eyes in the narrow angle group developed appositional angle closure in the dark. CONCLUSIONS The dynamic dark-light changes of the anterior chamber angle can be imaged and analyzed with anterior segment OCT. Although the angle width generally decreased linearly with increasing pupil diameter, the differences of the angle width measured in the dark and in the light varied substantially among individuals.
Endoplasmic Reticulum Stress-Mediated Apoptosis Contributing to High Glucose-Induced Vascular Smooth Muscle Cell Calcification

Vascular calcification (VC) is a common feature in patients with type 2 diabetes mellitus, a metabolic disorder that is characterized by hyperglycemia (high blood glucose) in the context of insulin resistance and a relative lack of insulin. Recently, a few studies have indicated that a high concentration of glucose amplifies the osteogenesis of vascular smooth muscle cells (VSMCs). Some previous reports state that endoplasmic reticulum (ER) stress-mediated apoptosis was activated in and contributed to VC. However, whether or not high glucose could induce ER stress-mediated apoptosis and then involve the pathogenesis of VC remains unclear. The purpose of the present study was to investigate whether high blood glucose-induced VC in diabetes mellitus is caused by the ER response and subsequent apoptosis. We examined the effects of high glucose on the ER stress response of VSMCs. High glucose treatment drastically increased the ER stress response in VSMCs. The high glucose-induced osteoblastic differentiation of VSMCs was significantly attenuated by pretreatment with 500 μM of 4-PBA (an ER stress inhibitor) prior to the exposure to high glucose, as evidenced by decreases in the expression of Runx2 and activity of alkaline phosphatase, as well as calcium nodules. These results suggest that high glucose induces the ER stress response and apoptosis, leading to high glucose-elicited VC.
Análise quantitativa de mastócitos na cicatrização de feridas tratadas com membranas de colágeno contendo própolis vermelha

Mastocitos sao celulas do tecido conjuntivo responsaveis pelo inicio da reacao inflamatoria e cronificacao do processo, e desempenham um papel importante na dinâmica do reparo cicatricial. O uso de membranas biologicas naturais ou sinteticas no reparo de feridas dermicas extensas, por sua vez, tem sido bastante discutido na literatura, especialmente aquelas a base de colageno, devido a biocompatibilidade e interatividade desse material. A propolis e um produto natural que apresenta atividade anti-inflamatoria, podendo contribuir para a reparacao cicatricial. A variedade vermelha desse produto, contudo, ainda e pouco estudada, existindo alguns relatos de uma provavel acao cicatrizante. Assim, o objetivo deste trabalho foi analisar o efeito da associacao de membranas de colageno a propolis vermelha sobre a populacao de mastocitos durante o reparo cicatricial por segunda intencao em ratos. Para tanto, foram preparadas membranas de colageno I extraido de tendao bovino (10-15mm de espessura) contendo extrato hidroalcoolico de propolis vermelha a 0,1%. Posteriormente, foram realizadas feridas de 1cm 2 no dorso de 30 ratos Wistar, que foram distribuidos em seis grupos (n=5): G1 – animais sem tratamento sacrificados em 7 dias; G2 – animais tratados com membrana de colageno sacrificados em 7 dias; G3 – animais tratados com membrana de colageno contendo propolis vermelha sacrificados em 7 dias; G4 – animais sem tratamento sacrificados em 14 dias; G5 – animais tratados com membrana de colageno sacrificados em 14 dias; G6 – animais tratados com membrana de colageno contendo propolis vermelha sacrificados em 14 dias. Os especimes removidos foram fixados, processados histologicamente e emblocados em parafina e seccoes histologicas foram coradas em Azul de toluidina. Ao setimo dia, a populacao media de mastocitos total e marginal em G1 mostrou-se significativamente menor que em G2 e G3 (p<0,05), mas nao houve diferenca entre os dois ultimos. Ao decimo quarto dia nao foi observada diferenca estatisticamente significativa entre o G4, G5 e G6 nem na media total de mastocitos, nem nas duas regioes estudadas separadamente. Sugere-se que, em ratos, o uso de membranas bioativas de colageno, independentemente de conter ou nao propolis vermelha sob a forma de extrato hidroalcoolico a 0,1%, pode reduzir a desgranulacao de mastocitos aos sete dias de cicatrizacao de feridas abertas, mas nao influencia a populacao desta celula imunocompetente nas fases finais (14 dias) do reparo.
Beyond the Mental Hospital: Crisis Intervention and Continuity of Care in Trieste. A Four Year Follow-Up Study in a Community Mental Health Centre

A sample group of 39 new patients with acute and severe crises underwent a 4-year follow-up study at the community mental health center in Trieste (CMHC). The CMHC is a full-time service, open 24 hours a day and 7 days a week, and is fully integrated into a network of services which has completely replaced the preexisting mental hospital. Evaluation shows: 1) a generally good outcome of the initial crisis; 2) a low relapse rate; 3) a tendency towards favourable long-term outcomes. In terms of practice, voluntary and compulsory hospitalization were avoided in favor of short-term day and night support in the CMHC. There were no suicides, no crimes, no drop-outs. Social adjustment remained unchanged. Accessibility and continuity of care were favored by not separating special crisis services. Instead, crisis intervention was integrated into a comprehensive Mental Health Service offering a wide range of preventive and rehabilitative responses. The study demonstrates that the mental health services in Trieste are able to cope with acute crises without psychiatric hospitalization.
Acceptability of Carraguard vaginal gel use among Thai couples

Objectives:To evaluate the acceptability of candidate microbicide Carraguard among couples participating in a safety trial. Study design:A 6-month randomized, placebo-controlled trial was conducted in sexually active, low-risk couples in Thailand. Methods:Couples who were monogamous, HIV uninfected, and not regular condom users were enrolled. Acceptability data were collected through structured questionnaires at repeated intervals. At the closing study visit, participants were asked questions about hypothetical product characteristics and future use. Compliance with gel use was assessed by questionnaires, coital diaries, and tracking of used and unused applicators. Results:Among 55 enrolled couples, follow up and adherence with gel use were high and sustained, with 80% of women using gel in over 95% of vaginal sex acts. Because acceptability results from Carraguard and placebo arms were similar, they were combined for this analysis. Overall, 92% of women and 83% of men liked the gel somewhat or very much; 66% of women and 72% of men reported increased sexual pleasure with gel use; and 55% of women and 62% of men reported increased frequency of intercourse. Only 15% of women but 43% of men thought that gel could be used without the man knowing. Although men and women had similar views overall, concordance within couples was low, with no kappa coefficients above 0.31. Conclusion:Carraguard gel use was acceptable to low-risk couples in northern Thailand. Reported associations between gel use and increased sexual pleasure and frequency suggest a potential to market microbicide products for both disease prevention and enhancement of pleasure.
Morphological, chemical and species delimitation analyses provide new taxonomic insights into two groups of Rinodina

Abstract The genus Rinodina (Physciaceae), with approximately 300 species, has been subject to few phylogenetic studies. Consequently taxonomic hypotheses in Rinodina are largely reliant on phenotypic data, while hypotheses incorporating DNA dependent methods remain to be tested. Here we investigate Rinodina degeliana/R. subparieta and the Rinodina mniaraea group, which previously have not been subjected to comprehensive molecular and phenotypic studies. We conducted detailed morphological, anatomical, chemical, molecular phylogenetic and species delimitation studies including 24 newly sequenced specimens. We propose that Rinodina degeliana and R. subparieta are conspecific and that chemical morphs within the R. mniaraea group should be recognized as distinct species. We also propose the placement of the recently described genus Oxnerella in Physciaceae.
A murine model for the study of edema induced intestinal contractile dysfunction

Background We have published extensively regarding the effects of edema on intestinal contractile function. However, we have found the need to expand our model to mice to take advantage of the much larger arsenal of research support, especially in terms of transgenic mouse availability and development. To that end, we have developed and validated a hydrostatic intestinal edema model in mice.