Miracle-dz/UniFAR-FTUs huggingface dataset:
Formation of Singularities and Existence of Global Continuous Solutions for the Compressible Euler Equations

We are concerned with the formation of singularities and the existence of global continuous solutions of the Cauchy problem for the one-dimensional non-isentropic Euler equations for compressible fluids. For the isentropic Euler equations, we pinpoint a necessary and sufficient condition for the formation of singularities of solutions with large initial data that allow a far-field vacuum --- there exists a compression in the initial data. For the non-isentropic Euler equations, we identify a sufficient condition for the formation of singularities of solutions with large initial data that allow a far-field vacuum --- there exists a strong compression in the initial data. Furthermore, we identify two new phenomena --- decompression and de-rarefaction --- for the non-isentropic Euler flows, different from the isentropic flows, via constructing two respective solutions. For the decompression phenomenon, we construct a first global continuous non-isentropic solution, even though initial data contain a weak compression, by solving an inverse Goursat problem, so that the solution is smooth, except on several characteristic curves across which the solution has a weak discontinuity (i.e., only Lipschitz continuity). For the de-rarefaction phenomenon, we construct a continuous non-isentropic solution whose initial data contain isentropic rarefactions (i.e., without compression) and a locally stationary varying entropy profile, for which the solution still forms a shock wave in a finite time.
Security Vulnerabilities in Hybrid Flow-Specific Traffic-Adaptive Medium Access Control

Wireless network security is a daunting challenge as researchers analyze the vulnerabilities of wireless medium access control schemes such as IEEE 802.11, Bluetooth, and IEEE 802.16. While these wireless protocols employ traditional contention and non-contention approaches, recent work has identified the delay and throughput performance advantages of a flow-specific medium access hybrid solution for wireless networks such as the traffic-adaptive Cooperative Wireless Sensor Medium Access Control (CWS-MAC) protocol. Accordingly, this paper addresses the security of wireless networks employing these hybrid, flow-specific schemes by analyzing the vulnerabilities in traffic-adaptive CWS-MAC, many of which are applicable to hybrid medium access schemes in general. Critical vulnerabilities are identified that expose the protocol to denial of service, energy exhaustion and "greedy" attacks. The effect of attacks exploiting these vulnerabilities are shown to include decreased throughput and increased delay in both the contention and non-contention modes as well as increased per node energy consumption.
Metabolically programmed quality control system for dolichol-linked oligosaccharides

Significance In mammals, asparagine (N)-linked glycosylation of nascent polypeptides synthesized in the endoplasmic reticulum regulates folding, degradation, and intracellular trafficking of the glycoproteins. The normal N-glycosylation requires the completely-assembled dolichol-linked oligosaccharide (DLO) as the optimal glycan donor substrate; however, a low-glucose environment causes arrest of the DLO assembly, which results in the synthesis of extensively truncated premature DLOs, thereby increasing a risk of abnormal N-glycosylation. Here, we report that under low-glucose conditions, the premature DLOs are efficiently degraded by unidentified pyrophosphatase, catabolizing them to singly phosphorylated oligosaccharides. Our results suggest that the pyrophosphatase-mediated degradation of premature DLOs functions as a quality control system to avoid abnormal N-glycosylation under conditions that impair efficient DLO biosynthesis. The glycolipid Glc3Man9GlcNAc2-pyrophosphate-dolichol serves as the precursor for asparagine (N)-linked protein glycosylation in mammals. The biosynthesis of dolichol-linked oligosaccharides (DLOs) is arrested in low-glucose environments via unknown mechanisms, resulting in abnormal N-glycosylation. Here, we show that under glucose deprivation, DLOs are prematurely degraded during the early stages of DLO biosynthesis by pyrophosphatase, leading to the release of singly phosphorylated oligosaccharides into the cytosol. We identified that the level of GDP-mannose (Man), which serves as a donor substrate for DLO biosynthesis, is substantially reduced under glucose deprivation. We provide evidence that the selective shutdown of the GDP-Man biosynthetic pathway is sufficient to induce the release of phosphorylated oligosaccharides. These results indicate that glucose-regulated metabolic changes in the GDP-Man biosynthetic pathway cause the biosynthetic arrest of DLOs and facilitate their premature degradation by pyrophosphatase. We propose that this degradation system may avoid abnormal N-glycosylation with premature oligosaccharides under conditions that impair efficient DLO biosynthesis.
The TrieJax Architecture: Accelerating Graph Operations Through Relational Joins

Graph pattern matching (e.g., finding all cycles and cliques) has become an important component in domains such as social networks, biology and cyber-security. In recent years, the database community has shown that graph pattern matching problems can be mapped to an efficient new class of relational join algorithms. In this paper, we argue that this new class of join algorithms is highly amenable to specialized hardware acceleration thanks to two fundamental properties: improved memory locality and inherent concurrency. The improved locality is a result of the bound number of intermediate results these algorithms generate, which yields smaller working sets. Coupled with custom caching mechanisms, this property can be used to dramatically reduce the number of main memory accesses invoked by the algorithm. In addition, their inherent concurrency can be leveraged for effective hardware acceleration and hiding memory latency. We demonstrate the hardware amenability of this new class of algorithms by introducing TrieJax, a hardware accelerator for graph pattern matching that can be tightly integrated into existing manycore processors. TrieJax employs custom caching mechanisms and a massively multithreaded design to dramatically accelerate graph pattern matching. We evaluate TrieJax on a set standard graph pattern matching queries and datasets. Our evaluation shows that TrieJax outperforms recently proposed hardware accelerators for graph and database processing that do not employ the new class of algorithms by 7 - 63× on average (up to 539×), while consuming 15 - 179× less energy (up to 1750×), and systems that incorporate modern relational join algorithms by 9 - 20× on average (up to 45×), while consuming 59 - 110× less energy (up to 372×).
The sialidase superfamily and its spread by horizontal gene transfer

Sialidases (neuraminidases, EC 3.2.1.18) belong to a class of glycosyl hydrolases that release terminal N‐acylneuraminate (slalic acid) residues from glycoproteins, glycolipids, and polysaccharides. These enzymes are common in animals of the deuterostomate lineage (Echinodermata through Mammalia) and also in diverse microorganisms that mostly exist as animal commensals or pathogens. Sialidases, and their sialyl substrates, appear to be absent from plants and most other metazoans. Even among bacteria, sialidase is found irregularly so that related species or even strains of one species differ in this property. This unusual phylogenetic distribution makes sialidases interesting for evolutionary studies. The biochemical diversity among bacterial sialidases does not indicate close relationships. However, at the molecular level, homologies are detectable, supporting the hypothesis of a common sialidase origin and thus of a sialidase super family. Some findings indicate that sialidase genes were recently transferred via phages among bacteria. The proposal of a sialidase origin in higher animals is suggested by the presence of apparently homologous enzymes in this kingdom, supporting the idea that some microbes may have acquired the genetic information during association with their animal hosts.
The Presence and Prognostic Importance of Glomerular Macrophage Infiltration in Renal Allografts

Aim: The purpose of this study was to analyze the role of intraglomerular macrophage infiltration in human renal allografts by examining biopsies from kidney grafts that were dysfunctional after transplantation. Methods: Eighty-three patients (58 men, 25 women) of a mean age of 30.2 ± 1.4 years were evaluated. In all cases, biopsy specimens were examined for the presence of macrophage infiltration in the glomeruli. The infiltration of these cells was evaluated immunohistochemically using monoclonal antibody CD68, which labels macrophage cytoplasm. 10 renal allograft biopsies with normal histopathology were used as control group. The CD68-positive macrophages in all glomeruli were counted and the glomerular macrophage index (GMI) was calculated. Results: Of the 83 patients, 40 showed acute rejection (AR), 33 showed chronic rejection (CR) and 10 showed cyclosporin A (CsA) toxicity. Only the biopsies of 28 patients stained positive for CD68 in the glomeruli. Neither patients with CsA toxicity nor controls showed intraglomerular macrophages. The CD68-positive group consisted of 7/33 CR and 21/40 AR patients. We observed intraglomerular macrophages in only 6 of the 20 AR cases that responded to steroid therapy (mean GMI 0.3 ± 0.1) and in 15 of the 20 steroid-resistant AR cases (mean GMI 1.7 ± 1.2; p < 0.01). The outcome of grafts that contained intraglomerular macrophages was significantly worse than the outcomes of other grafts noticed during the follow-up. Conclusion: We conclude that the presence of glomerular macrophages can be considered a marker for rejection and is a valuable additional criterion of rejection in the histological examination of renal allograft biopsies. The presence of intraglomerular macrophages indicates that the outcome of the graft will be significantly worse than that of grafts without intraglomerular macrophage infiltration.
Strength Training Increases Endurance Time to Exhaustion During High-Intensity Exercise Despite No Change in Critical Power

Abstract Sawyer, BJ, Stokes, DG, Womack, CJ, Morton, RH, Weltman, A, and Gaesser, GA. Strength training increases endurance time to exhaustion during high-intensity exercise despite no change in critical power. J Strength Cond Res 28(3): 601–609, 2014—The purpose of this study was to determine whether improvements in endurance exercise performance elicited by strength training were accurately reflected by changes in parameters of the power-duration hyperbola for high-intensity exercise. Before and after 8 weeks of strength training (N = 14) or no exercise, control (N = 5), 19 males (age: 20.6 ± 2.0 years; weight: 78.2 ± 15.9 kg) performed a maximal incremental exercise test on a cycle ergometer and also cycled to exhaustion during 4 constant-power exercise bouts. Critical power (CP) and anaerobic work capacity (W′) were estimated using nonlinear and linear models. Subjects in the strength training group improved significantly more than controls (p < 0.05) for strength (∼30%), power at V[Combining Dot Above]O2peak (7.9%), and time to exhaustion (TTE) for all 4 constant-power tests (∼39%). Contrary to our hypothesis, CP did not change significantly after strength training (p > 0.05 for all models). Strength training improved W′ (mean range of improvement = +5.8 to +10.0 kJ; p < 0.05) for both linear models. Increases in W′ were consistently positively correlated with improvements in TTE, whereas changes in CP were not. Our findings indicate that strength training alters the power-duration hyperbola such that W′ is enhanced without any improvement in CP. Consequently, CP may not be robust enough to track changes in endurance capacity elicited by strength training, and we do not recommend it to be used for this purpose. Conversely, W′ may be the better indicator of improvement in endurance performance elicited by strength training.
Neurological Abnormalities Associated with Severity of Dementia in Alzheimer's Disease

Abstract: Abnormal findings on neurological examination were evaluated in 165 patients with a clinical diagnosis of Alzheimer's disease who attended a memory disorders clinic. Severity of dementia was measured by the Blessed Dementia Scale, and associations of abnormalities with dementia severity were evaluated using logistic regression. Presence of aphasia, apraxia, and primitive reflexes on neurological examination were strongly associated with severity, and weak associations were observed for abnormalities of muscle tone and gait. Among these associated neurological features, only aphasia and apraxia were present in mildly demented cases with sufficient frequency to suggest utility as diagnostic signs early in the course of the disease.
Multifunctional poly(alkyl methacrylate) films for dental care

Towards the evaluation of non-permanent dental coatings for their capacity to impart dental-care benefits, thin films of a homologous series of comb-like poly(alkyl methacrylate)s (ethyl to octadecyl) have been deposited, from aqueous latex formulations, onto dentally relevant substrates. AFM studies have shown that the thickness (40–300 nm) and surface roughness (8–12 nm) of coherent polymer films are influenced by the degree of polymerization and by the length of the pendant chain. Of the polymers under consideration, poly(butyl methacrylate) formed a close-packed film that conferred to dental substrates a high degree of inhibition to acid-mediated erosion (about 27%), as evaluated by released-phosphate determinations. The potential utility of the coatings to act as anti-sensitivity barriers has been evaluated by determining the hydraulic conductance of coated bovine-dentine substrates; single treatments of dentine discs with poly(butyl methacrylate) or with poly(ethyl methacrylate) effected mean respective reductions in fluid flow of about 23% with respect to water-treated controls; repeated applications of the poly(butyl methacrylate) latex led to mean reductions in fluid flow of about 80%. Chromometric measurements have shown that pellicle-coated hydroxyapatite discs treated with poly(butyl methacrylate), poly(hexyl methacrylate) or poly(lauryl methacrylate) exhibit significant resistance to staining by food chromogens.
Invertebrate immune systems – not homogeneous, not simple, not well understood

Summary: The approximate 30 extant invertebrate phyla have diversified along separate evolutionary trajectories for hundreds of millions of years. Although recent work understandably has emphasized the commonalities of innate defenses, there is also ample evidence, as from completed genome studies, to suggest that even members of the same invertebrate order have taken significantly different approaches to internal defense. These data suggest that novel immune capabilities will be found among the different phyla. Many invertebrates have intimate associations with symbionts that may play more of a role in internal defense than generally appreciated. Some invertebrates that are either long lived or have colonial body plans may diversify components of their defense systems via somatic mutation. Somatic diversification following pathogen exposure, as seen in plants, has been investigated little in invertebrates. Recent molecular studies of sponges, cnidarians, shrimp, mollusks, sea urchins, tunicates, and lancelets have found surprisingly diversified immune molecules, and a model is presented that supports the adaptive value of diversified non‐self recognition molecules in invertebrates. Interactions between invertebrates and viruses also remain poorly understood. As we are in the midst of alarming losses of coral reefs, increased pathogen challenge to invertebrate aquaculture, and rampant invertebrate‐transmitted parasites of humans and domestic animals, we need a better understanding of invertebrate immunology.
Evaluation of Nifurtimox Treatment of Chronic Chagas Disease by Means of Several Parasitological Methods

ABSTRACT Currently, evaluation of drug efficacy for Chagas disease remains a controversial issue with no consensus. In this work, we evaluated the parasitological efficacy of Nifurtimox treatment in 21 women with chronic Chagas disease from an area of endemicity in Chile who were treated according to current protocols. Under pre- and posttherapy conditions, blood (B) samples and xenodiagnosis (XD) samples from these patients were subjected to analysis by real-time PCR targeting the nuclear satellite DNA of Trypanosoma cruzi (Sat DNA PCR-B, Sat DNA PCR-XD) and by PCR targeting the minicircle of kinetoplast DNA of T. cruzi (kDNA PCR-B, kDNA PCR-XD) and by T. cruzi genotyping using hybridization minicircle tests in blood and fecal samples of Triatoma infestans feed by XD. In pretherapy, kDNA PCR-B and kDNA PCR-XD detected T. cruzi in 12 (57%) and 18 (86%) cases, respectively, whereas Sat DNA quantitative PCR-B (qPCR-B) and Sat DNA qPCR-XD were positive in 18 cases (86%) each. Regarding T. cruzi genotype analysis, it was possible to observe in pretherapy the combination of TcI, TcII, and TcV lineages, including mixtures of T. cruzi strains in most of the cases. At 13 months posttherapy, T. cruzi DNA was detectable in 6 cases (29.6%) and 4 cases (19.1%) by means of Sat DNA PCR-XD and kDNA PCR-XD, respectively, indicating treatment failure with recovery of live parasites refractory to chemotherapy. In 3 cases, it was possible to identify persistence of the baseline genotypes. The remaining 15 baseline PCR-positive cases gave negative results by all molecular and parasitological methods at 13 months posttreatment, suggesting parasite response. Within this follow-up period, kDNA PCR-XD and Sat DNA qPCR-XD proved to be more sensitive tools for the parasitological evaluation of the efficacy of Nifurtimox treatment than the corresponding PCR methods performed directly from blood samples.
Inflammation: implications for understanding the heart-brain connection.

A utonomic dysfunction is a strong correlate of morbidity and mortality in cardiovascular disease. While increased sympathetic stimulation drives many adverse events in coronary artery disease and heart failure, beta-adrenergic blockade is associated with improved outcomes. Similarly, diminished parasympathetic tone is also associated with adverse outcomes in cardiovascular disease, suggesting a key role for this limb of the autonomic system in maintenance of cardiac homeostasis. The mechanism of parasympathetic protection, however, is not clearly understood. Although an antiarrhythmic mechanism appears intuitive, such a mechanism has not been corroborated by animal studies. Recently, Tracey and colleagues provided new insight by demonstrating that parasympathetic stimulation in mice and in human macrophages results in a decreased release of mediators of systemic inflammation. Given the importance of inflammation in atherosclerosis and adverse remodeling in congestive heart failure, it is possible that parasympathetic tone assuages atherogenesis and deleterious cardiac remodeling by directly inhibiting inflammation.
Noninferiority of IncobotulinumtoxinA, Free from Complexing Proteins, Compared with Another Botulinum Toxin Type A in the Treatment of Glabellar Frown Lines

BACKGROUND Use of botulinum toxin for esthetic purposes has rapidly expanded over the last 20 years. IncobotulinumtoxinA, also known as NT 201, is a new botulinum toxin type A (150 kDa) that is free from complexing proteins. OBJECTIVES A prospective, multicenter, randomized, rater‐ and patient‐blind, international Phase III trial to investigate the noninferiority of incobotulinumtoxinA to another botulinum toxin type A, onabotulinumtoxinA, in the treatment of glabellar frown lines. METHODS A total of 381 patients were randomized in a 3:1 (incobotulinumtoxinA:onabotulinumtoxinA) ratio to receive 24 U incobotulinumtoxinA of or onabotulinumtoxinA. Efficacy end points included the percentage of responders (patients with an improvement of ≥1 point on a 4‐point facial wrinkle scale) at maximum frown at weeks 4 and 12 as assessed by the investigators, and a panel of independent raters based on standardized digital photographs. RESULTS Four weeks after injection, response rates at maximum frown were 96.4% in the incobotulinumtoxinA group and 95.7% in the onabotulinumtoxinA group as assessed by independent raters. Analysis of the data confirmed the noninferiority of incobotulinumtoxinA. Response rates at rest were lower for both products. The rate of adverse events was low. CONCLUSION IncobotulinumtoxinA is equally as effective as onabotulinumtoxinA in the treatment of glabellar frown lines. Both preparations were well tolerated. This study was funded by Merz Pharmaceuticals GmbH. Editorial assistance was provided by Ogilvy 4D, Oxford, UK.
Evaluation of aortic elastic properties in patients with systemic sclerosis.

OBJECTIVES The aim of this study was to investigate the elastic properties of the aorta, which are known to be predictors of cardiovascular morbidity and mortality in patients with systemic sclerosis (SSc). STUDY DESIGN Forty patients (2 males, 38 females) with SSc who had been referred to echocardiography without any exclusion criteria were enrolled in the study. The control group consisted of 38 subjects (4 males, 34 females) who were examined in the cardiology out-patient clinic and referred to echocardiography for any indication in the same period. Parameters related to diastolic functions of the left ventricle were obtained by echocardiography and the following parameters of aortic elasticity were calculated according to these formulas: aortic strain = ([AOS - AOD]/AOD), aortic stiffness index (ß) = ln (systolic blood pressure/diastolic blood pressure)/aortic strain and aortic distensibility = 2 × aortic strain/pulse pressure. RESULTS Aortic strain and distensibility were significantly lower, and aortic stiffness index ß was significantly higher in the SSc group compared to the control group. While the systolic diameter of the aorta did not differ between study and control groups, the diastolic diameter of the aorta was significantly higher in SSc patients. On the other hand, left ventricular diastolic functions were compromised in the SSc group. Mitral A velocity, E-wave deceleration time and E/Em ratio were increased and mitral E/A ratio, lateral and medial annular Em velocity were significantly decreased in SSc patients. CONCLUSION Our study demonstrated that aortic stiffness is increased and left ventricular diastolic functions are compromised in patients with SSc.
[O iii] Emission line properties in a new sample of heavily reddened quasars at z > 2

We present VLT-SINFONI near infra-red spectra of 26 new heavily reddened quasar candidates selected from the UKIDSS-LAS, VISTA VHS and VIKING imaging surveys. This new sample extends our reddened quasar search to both brighter and fainter luminosities. 25 of the 26 candidates are confirmed to be broad line quasars with redshifts $0.7 2$. We present the first comparison of the [OIII] line properties in high luminosity obscured quasars to a large sample of 111 unobscured quasars in the same luminosity and redshift range. Broad wings extending to velocities of 2500 km/s are seen in the [OIII] emission line profiles of our reddened quasars, suggesting that strong outflows are affecting the ionised gas kinematics. However, we find no significant difference between the kinematics of the [OIII] emission in reddened and unobscured quasars when the two samples are matched in luminosity and redshift. Our results are consistent with a model where quasar-driven outflows persist for some time after the obscuring dust has been cleared from along the line of sight. Assuming the amount of ionised gas in obscured and unobscured quasars is similar, we use the equivalent width distribution of the [OIII] emission to constrain the location of the obscuring dust in our reddened quasars. We find that the dust is most likely to be located on galactic scales, outside the [OIII] emitting region.