Miracle-dz/UniFAR-FTUs huggingface dataset:
Quantifying subjective sleep quality: Does anxiety, mobile phone dependence and coping style predict sleep quality?

Sufficient and efficient sleep can be affected by an individual’s behaviour such as mobile phone dependence and management of daily life stressors through the use of coping styles. The current study explored whether the components of Consensus Sleep Diary would predict the composite score of Pittsburgh Sleep Quality Index (PSQI). In total, 29 participants completed a seven-day Consensus Sleep Diary and a one-off questionnaire assessing mobile phone dependence, anxiety, coping styles and PSQI at the end of the survey. The regression findings revealed a significant model of the sleep diary components predicting composite score of PSQI, global PSQI, but none of the sleep components significantly contributed to the outcome. Relative to other diary components, effect sizes of Wake After Sleep Onset (WASO) and Number of Awakenings (NWAK) were greater. A model was hypothesized suggesting that level of anxiety, mobile phone dependence, rational coping, detached coping, emotional coping and avoidant coping would predict the global PSQI. Although the hypothesized model was significant, only detached coping and emotional coping significantly predicted the sleep quality and with large effect. Results suggested that overall sleep quality may have a greater association with sleep fragmentation components like WASO, NWAK as well as detached and emotional coping styles. Therefore, for better sleep, the general population should improve their sleep continuation and the way they manage stress. Implications involve promoting healthy coping styles in universities, the work-place, clinical settings and awareness campaigns.
Clinical utility of pembrolizumab in the management of advanced solid tumors: an evidence-based review on the emerging new data

Abstract Pembrolizumab is a full-length human immunoglobulin G4 (IgG4) monoclonal antibody directed against the immune checkpoint PD-1 to remove its binding with PD-L1 and thus to restore an anti-tumor immune response of T cells. Pembrolizumab is one of the most advanced immune checkpoint inhibitors for cancer care. Apart from rare and serious adverse effects, its favorable tolerance profile enables to treat fragile patients who have often no other choice than best supportive care. The effective retained dose of pembrolizumab is a venous administration of 200 mg every 3 weeks until disease progression, intolerance or up to 24 months. Pembrolizumab has already proven its efficacy and thus obtained marketing authorization in so-called hot or hypermutated tumors or tumors expressing PD-L1 such as melanomas, non-small cell lung cancers, urothelial carcinomas, cervical cancer, etc. Pembrolizumab is also authorized in the United States in the treatment of mismatch repair-deficient tumors or with microsatellite instability. The current challenge is to expand its use in tumor types that are supposed to be less immunogenic, for example, by attempting to warm up the tumor microenvironment, or by combining pembrolizumab with other molecules. An acceptable toxicity profile of such combinations remains to explore. We review here the current indications of this drug, the main prognostic and predictive factors of its efficacy as well as the potential forthcoming indications.
Three Lions on Her Shirt: Hot and Banal Nationalism for England’s Sportswomen

It has long been claimed that sport plays an important role in the formulation of national identity. Key to understanding this relationship is Michael Billig’s concept of banal nationalism, which is used in this article to examine national symbols that act as daily reminders of the nation. Specifically, the article discusses the relationship between Englishness and sport by drawing upon data from interviews with representative English sportswomen in association football, cricket, netball, and rugby union. The article demonstrates the important role that (men’s) sport plays in developing a sense of national identity in England and, in particular, one that is distinct from Britishness. Furthermore, the significance of national symbols is evidenced as banal reminders of national identity for England’s sportswomen.
THE TURBULENT WEAK WALL-JET

Turbulent wall jets have many important engineering applications. Much effort has been spent to investigate the plane turbulent wall jet without external stream (Launder and Rodi 1981,1983, Katz et al 1992, Wygnanski et al 1992) and with a relatively slow external stream (Zhou and Wygnanski 1993, Zhou et al 1996). However, many engineering applications seem to be described better by a wall jet embedded in a uniform stream of comparable velocity (the weak wall jet), for example, the cooling turbine blades and the flows over a wing equipped with a slotted flap (Fig. 1) represents such flows. The recently developed technique for separation control by periodic blowing/suction on the flap also belongs to category (Fig.2). Thus, it is important to provide a better understanding of the development of these flows. For example: the possibility of flow similarity, normalization of the mean velocity fields, scaling laws for the governing parameters, as well as the various responses to external excitations. This report represents but a single facet of the general effort endeavoring to use the wall jet for boundary layer control, film cooling and the exertion of force on a body through the use of what is commonly known as the Coanda Effect.
Co-Infection of Cryptococcal and Multidrug Resistant Tuberculous Meningitis in Immunocompetent Patient

A rare, previously unreported case of concurrent central nervous system infection with Cryptococcus neoformans and multi-drug resistant Mycobacterium tuberculosis in a 27-year-old immunocompetent female patient who reported to a tertiary care centre in North India. Various diagnostic and case management difficulties encountered for the management of this case have been highlighted. Correct and complete etiological identification, enabling early, appropriate treatment in patients with concomitant infections may pose a diagnostic dilemma. The case highlights the need to maintain an increased level of clinical suspicion for co-infections with tuberculosis (TB), (especially in TB meningitis), even if there are no obvious signs of immunodeficiency, thereby indicating that TB could be the cause for immunosuppression, hence paving way for opportunistic infections.
Harapan Pasien, Kompetensi Pegawai, Kualitas Pelayanan dan Kepuasan Pasien

ABSTRACT This study aims to fine out the effect of patient's expectation on the service quality, to find out the effect of the competence of employees on the service quality, to find ut the effect of patient expectations on patient satisfaction, to find out the effect of employee competence on patient satisfaction, to find out the effect of service quality on patient satisfaction in dental Polyclinic of Udayana hospital. The research was conducted at Dental Polyclinic of Udayana Hospital. The data were collected using questionnaires using differential scale semantics. The number of samples was used 100 people. Data analysis technique by using SEM. The results showed the higher expectation of the patient hence higher the service quality accepted with CR value of 10,181 and sig 0,000. The higher employee’s competence hence the higher the service quality accepted with CR 4,308 and sig 0,000. The higher patient’s expectation hence the higher patient’s satisfaction accepted with CR 2,679 and sig 0,000. The higher employee’s competence hence the higher the patient's satisfaction accepted with CR 2,183 and sig 0,045. The higher the service quality hence the higher the patient’s satisfaction accepted with CR value of 5,874 and sig 0,000.
Gamified experimental physics classes: a promising active learning methodology for higher education

Gamification is defined as the use of game design elements in a non-game context. In higher education, gamification is a methodology intending to motivate students to acquire academical knowledge and soft skills, while keeping them engaged and pleased with the learning process. This study reports the application of a gamified class concerning electric resistors, the first of a 12-topic discipline offered to 2nd-year students in physics and engineering. Adopting a Flipped Classroom methodology and a narrative based on household power consumption, traditional contents about resistors and electricity were taught. Also, instructions about how to use an ohm-meter and how to configure an electronic spreadsheet to do basic statistics were given. In order to customize and enrich the class, some optional contents (usually in a video) were made available. The access to the experimental activities was constrained by approval in four graded quizzes. Every activity was acknowledged by virtual coins to be converted in benefits (extra time to run final examinations, permission to consult class appointments and the opportunity to re-discuss a mistake in the final examination) and points, to rank students (leaderboard). Forty-five students attended the gamified class. No control group was implemented because this study aimed to find a good design for a gamified class, not to compare traditional to active methodologies. The overall student acceptance was excellent, and they reported that gamification can be a more engaging methodology than traditional classes, further developing soft skills and academic knowledge. However, the time spent to run the gamified class must be arranged, reducing the time inside the classroom. The opportunity to perform the experiment was considered essential, and could not be substituted by videos or texts since new doubts and concerns are pointed out during the practice when the teacher is present. Gamification can be a methodology capable of engaging and being enjoyable students, giving them more than just information but also soft skills.
Realizing negative Poisson's ratio in spring networks with close-packed lattice geometries

When randomly displacing the nodes of a crystalline and unstressed spring network, we find that the Possion's ratio decreases with the increase of structural disorder and even becomes negative. Employing our finding that longer springs tend to contribute more to the shear modulus but less to the bulk modulus, we are able to achieve negative Poisson's ratio with lower structural disorder by attributing each spring a length dependent stiffness. Even with perfect crystalline structure, the network can have negative Possion's ratio, if the stiffness of each spring is set by its virtual length after a virtual network distortion. We also reveal that the nonaffine contribution arising from the structural or spring constant disorder produced in some cooperative way by network distortion is essential to the emergence of negative Poisson's ratio.
Radio frequency radiation measurement for base tower station safety compliances: a case study in Pulau Pinang Malaysia

The residence of Pulau Pinang and Malaysia generally are worried with the possible health effects due to Base Tower Station (BTS) radiation. Particularly, the residents of Pulau Pinang are utilizing their mobile phones for multiple kind of tasks including communications, browsing the internet and other applications. With the recent advances in mobile communication technologies, the end user demanded a better coverage, great communication services, and faster speed for internet browsing. To fulfill the demand, service provider and communication companies are providing plenty of communication base tower leading to the beliefs of that the tower emitted radiation and cause harmful effect to human health and voiced out and complain to the municipal councils in Malaysia. In this paper, a measurement was conducted to study electromagnetic fields (EMF) radiation level in Pulau Pinang. The measurement is compared with the international standard provided by International Commission of Non-Ionizing Radiation Protection (ICNIRP). Far field measurement of different values of long term evolution (LTE) exposure was demonstrated in radiofrequency (RF) shielded environment. LTE850, LTE1800 and LTE2600 field exposure was compared in term of its’ electrical field and power density that adhere to the standard provided by ICNIRP.
Efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome

Clinical efficacy of pulmonary surfactant combined with high-dose ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome (NRDS) was investigated. One hundred child patients with NRDS in Linyi Central Hospital were collected according to the diagnostic criteria for RDS in the Pediatrics, and randomly divided into the treatment group (n=50) and the control group (n=50) based on different therapeutic methods. Patients in the control group were treated with basic treatment and high-dose ambroxol hydrochloride injection, while those in the treatment group were additionally administered with pulmonary surfactant Curosurf based on conventional therapy in the control group. The chest X-rays were collected before the treatment and at 12 h after the drug administration, the degree of respiratory distress in child patients was observed and evaluated via Silverman grading, and changes in blood gas indexes were recorded before treatment and at 2, 6 and 12 h after the drug administration. The chest X-ray grade, Silverman grade and blood gas analysis results had no differences between the two groups before the treatment (P>0.05). In the treatment group, partial pressure of oxygen (PaO2) and PH were increased and partial pressure of carbon dioxide (PaCO2) was decreased compared with those in the control group at 2, 6 and 12 h after the drug administration (P<0.05). At 12 h after the drug administration, chest X-ray grade and Silverman grade in both groups were improved, which were significantly superior in the treatment group to those in the control group (P<0.01). Moreover, the efficacy in the treatment group was remarkably better than that in the control group at 12 h after drug administration (P<0.01). Pulmonary surfactant combined with high-dose ambroxol hydrochloride has definite efficacy in the treatment of NRDS, which can significantly improve the pulmonary infection, respiratory distress and blood gas indexes of child patients.
Environmental Literacy: An Assessment and Evaluation on the Students of Landscape Architecture in Turkey

Environmental literacy approach, in recent years, become one of the fundamental requirements proposed for a sustainable future in higher education. Environmental literacy is the total of individual comprehension, ability, attitude and habits which are constantly in progress and it is based on that short and long term attitudes and behaviors are developed by his sustainable communication with other people and biosphere. This study aims to evaluate the environmental consciousness, knowledge and skills of the students of landscape architecture in terms of environmental literacy. As data collection tool was used Environmental Literacy Scale where the knowledge of students about environmental legislation, knowledge and behaviors is questioned. The findings reveal that students have a very limited environmental knowledge and fulfill their environmental responsibilities on an individual basis in a very restricted area. In this regard, the study, based on the research results, makes suggestions for training environmentally literate candidates in professional training of environmental by emphasizing that students of Landscape Architecture would be of low efficiency in finding creative solutions for environmental, societal and spatial problems and producing sustainable landscape since their participation is very limited in societal and mass activities.
The Development of Silica Hydride Stationary Phases for High-Performance Liquid Chromatography from Conception to Commercialization

The development of a stationary phase material for high-performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization, and applications. There are several synthetic approaches available to create a silica hydride surface. Modification of the Si–H moiety on the silica surface can be accomplished through the use of a hydrosilation reaction. Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods. Further insights into the retention mechanism are provided through chromatographic measurements. The ultimate utility of any chromatographic stationary phase material is determined by its success in solving challenging analytical problems. A broad range of applications is reviewed to illustrate the versatility and usefulness of silica hydride-based stationary phases.
Efectos de la ansiedad prequirúrgica en la recuperación

This study investigates the influence of different worries about hospitalization and surgical intervention on presurgical anxiety, and the effects, in turn, of presurgical anxiety on postsurgical recovery. The study sample was made up of thirty male patients between the ages of 78 and 65, scheduled to have an elective operation for inguinal hernia. Presurgical anxiety was assessed the day prior to surgery, using three different questionnaires. Results showed that the worries most closely associated with presurgical anxiety were those related to postsurgical pain and discomfort, anesthesia and possible problems during intervention. Four recovery indices (analgesics and sedatives intake, number of days to discharge and pain) were found to be influenced by presurgical psychological state. In general, patients who were more anxious and worried before surgical intervention experienced a more difficult recovery, The efficacy of the three different anxiety questionnaires in the evaluation of presurgical anxiety is discussed
Early Signs of Physical Overstrain of the Cardiovascular System in Athletes with Symptoms of Connective Tissue Dysplasia

In some cases, individuals with the signs of connective tissue dysplasia, in particular with small abnormalities of the development of the heart are allowed to take sports. The purpose of the study was to improve the medical and pedagogical support of the training process of athletes with signs of connective tissue dysplasia by substantiating the early criteria of acute physical overstrain of the cardiovascular system. 247 athletes were examined, 59 of them with signs of systemic involvement of connective tissue in the dysplastic process. The medical criteria for admission and the planning of training-competitive loads in athletes are established, taking into account the influence of external and visceral signs of connective tissue dysplasia on the functional state of the organism. Early signs of overstrain of cardiac function during exercise of athletes with signs of connective tissue dysplasia were symptoms of disturbance of myocardial relaxation by the indicators of diastolic function of the heart, therewith the ejection fraction at rest can be maintained at normal levels. The presence of signs of connective tissue dysplasia in athletes with different predicted states requires sports doctors and trainers to conduct in-depth analysis and differential diagnostics of clinical forms in order to prevent complications during trainingcompetitive loads.
Neural tube development depends on notochord-derived sonic hedgehog released into the sclerotome

ABSTRACT Sonic hedgehog (Shh), produced in the notochord and floor plate, is necessary for both neural and mesodermal development. To reach the myotome, Shh has to traverse the sclerotome and a reduction of sclerotomal Shh affects myotome differentiation. By investigating loss and gain of Shh function, and floor-plate deletions, we report that sclerotomal Shh is also necessary for neural tube development. Reducing the amount of Shh in the sclerotome using a membrane-tethered hedgehog-interacting protein or Patched1, but not dominant active Patched, decreased the number of Olig2+ motoneuron progenitors and Hb9+ motoneurons without a significant effect on cell survival or proliferation. These effects were a specific and direct consequence of Shh reduction in the mesoderm. In addition, grafting notochords in a basal but not apical location, vis-à-vis the tube, profoundly affected motoneuron development, suggesting that initial ligand presentation occurs at the basal side of epithelia corresponding to the sclerotome-neural tube interface. Collectively, our results reveal that the sclerotome is a potential site of a Shh gradient that coordinates the development of mesodermal and neural progenitors. Summary: Loss- and gain-of-function, and floor plate deletions, reveal that Shh that transits through the sclerotome is presented to the neuroepithelium from its basal aspect to affect motoneuron development.
Vitamin D supplementation ameliorates arthritis but does not alleviates renal injury in pristane-induced lupus model

Abstract Systemic lupus erythematosus (SLE) is a multifactorial and autoimmune inflammatory disease with pleomorphic clinical manifestations involving different organs and tissues. The study of different murine models has provided a better understanding of these autoimmune phenomena. Pristane-induced lupus represents a suitable model to study factors that could influence the induction and/or progression of SLE, including genetic factors. The objective of the present study was to evaluate the development and evolution of SLE after vitamin D supplementation in PIL model. Here, we evaluated the effects of vitamin D supplementation in model of pristane-induced SLE in female BALB/c mice. The animals were randomly divided into three groups: control group (CO), pristane-induced lupus group (PIL) and pristane-induced lupus group plus vitamin D (VD). Lupus was induced in PIL and VD groups using pristane. PIL group showed arthritis and kidney injury, characterized by increased proteinuria, glomerular mesangial expansion and inflammation. Moreover, PIL model showed increased levels of IL-6, TNF-α and IFN-γ in serum. We observed that treatment with vitamin D improved arthritis through reduced of incidence and arthritis clinical score and edema, but does not influenced renal injury. Treatment with vitamin D was not able to reduce proteinuria levels, decrease mesangial hypercellularity or IgG and IgM deposition in the kidney. Vitamin D supplementation did not alter IL-6, TNF-α, IL-2 and IL-4, but reduce IFN-γ. These results support that the role of vitamin D may be different depending on acting site, what could explain different responses according clinical phenotype. Therefore, further investigations of vitamin D are needed to explore the supplement dosage, timing, and the molecular basis in SLE.
KAJIAN LEARNING MANAGEMENT SYSTEM (LMS) DENGAN QUALITATIVE WEIGHT AND SUM (QWS): STUDI KASUS D3 UNGGULAN UNIVERSITAS BUDI LUHUR

Learning Management System (LMS) is software that virtualizes conventional teaching and learning process. LMS is one of component which is need for developing e-learning and it’s also a software to support e-learning method. LMS D3 Unggulan Budi Luhur University needs to evaluate how far LMS support E-learning method. Qualitative Weight and Sum (QWS) method is use to evaluate this LMS. The purpose of this research is to know criterias for the evaluation. Those criterias based on Learning Management System’s features which grouped by categories and sub-categories.The results of the evaluation with QWS method show that most of the features on LMS D3 Unggulan Budi Luhur University already meet the criterias so that LMS can support e-learning method. Keywords: Learning Management System, LMS, Qualitative Weight and Sum, QWS