Miracle-dz/UniFAR-FTUs huggingface dataset:
Pulse detection algorithm for line-of-sight (LOS) UWB ranging applications

This paper presents an algorithm for precise determination of the distance between a pair of transmitting and receiving antennas using FCC conforming ultra-wideband (UWB) pulses. Indoor line-of-sight (LOS) measurements up to 24 m were conducted at Research Technoplaza, Nanyang Technological University, Singapore. The proposed algorithm is developed using Matlab to post process the captured waveform. Significant improvement of accuracy is observed in determining the time of flight using a combination of match filtering and peak search technique, achieving centimeter level accuracy. Ranging results show a worst case standard deviation of 2 cm for distance up to 8 m and 10.6 cm for distance up to 24 m.
Plasticity in the Purine–Thiamine Metabolic Network of Salmonella

In Salmonella enterica, 5-aminoimidazole ribonucleotide (AIR) is the precursor of the 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) pyrophosphate moiety of thiamine and the last intermediate in the common HMP/purine biosynthetic pathway. AIR is synthesized de novo via five reactions catalyzed by the purF, -D, -T, -G, and -I gene products. In vivo genetic analysis demonstrated that in the absence of these gene products AIR can be generated if (i) methionine and lysine are in the growth medium, (ii) PurC is functional, and (iii) 5-amino-4-imidazolecarboxamide ribotide (AICAR) has accumulated. This study provides evidence that the five steps of the common HMP/purine biosynthetic pathway can be bypassed in the synthesis of AIR and thus demonstrates that thiamine synthesis can be uncoupled from the early purine biosynthetic pathway in bacteria.
Startle and Surprise on the Flight Deck

Startle and surprise are often cited as potentially contributing factors to aircraft incidents due to their possible negative effects on flightcrew performance. In this paper, we provide definitions of startle and surprise with the goal of delineating their differences. In the past, these terms have often been used interchangeably; however, there are distinctive conceptual, behavioral, and physiological differences between the startle reflex and the surprise emotion. Furthermore, we investigated the prevale nce of startle and surprise on the flight deck by examining voluntary incident reports in the Aviation Safety Reporting System (ASRS) and found surprise to be more prevalent than startle. Implications of these findings and limitations of our initial exploratory analysis are discussed.
Competencia de los cuidadores familiares para cuidar a los pacientes con falla cardíaca

Introduccion: El cuidador familiar es la fuente mas importante de apoyo social y requiere desarrollar habilidades para reforzar las conductas de autocuidado en su familiar. El objetivo de este estudio fue determinar la competencia de cuidado de los cuidadores familiares de los pacientes con falla cardiaca (FC) en una institucion de cuarto nivel de complejidad. Materiales y Metodos: Estudio descriptivo de corte transversal. Con un tamano de muestra de 41 cuidadores familiares de personas con FC que asisten al programa de FC en una institucion de salud de cuarto nivel, durante el segundo semestre del 2016. Para la recoleccion de la informacion se utilizo el instrumento “CUIDAR” que cuenta con pruebas de validez de constructo y consistencia interna con un alfa de Cronbach de 0.93. Se realizo un analisis descriptivo con distribucion de frecuencias absolutas y relativas. Resultados: El nivel de competencia global para el cuidado en el hogar de los cuidadores familiares de los pacientes con FC fue medio y alto. Las dimensiones que alcanzaron un nivel mas alto de competencia fueron Disfrutar e Instrumental y Procedimental. Discusion: Una adecuada competencia para el cuidado en los cuidadores se convierte en un factor que puede influir de manera positiva en el manejo de la persona. Conclusiones: Una adecuada competencia del cuidador familiar va a permitir una mejor adaptacion a los nuevos requerimientos de la vida del paciente con su enfermedad y pueden ayudar a prevenir las descompensaciones. Como citar este articulo: Achury DM, Restrepo A, Torres NM, Buitrago AL, Neira NX, Devia P. Competencia de los cuidadores familiares para cuidar a los pacientes con falla cardiaca. Rev Cuid. 2017; 8(3): 1721-32. http://dx.doi. org/10.15649/cuidarte.v8i3. 407
Uncertainty About Informed Trading in Dealer Markets - An Experiment

We use an economic experiment to examine the impact of an uncertain level of asymmetric information on the behavior of security dealers. Specifically, we distinguish three types of uncertainty with respect to informed trading - risk, compound risk, and ambiguity - for both a monopoly and a duopoly market setting. We find no difference in dealers' bidding behavior between compound risk and ambiguity. At the same time, we find that bidding behavior is more aggressive under risk than under compound risk or ambiguity. In addition, we find that stochastic models of choice does well in explaining the observed differences in market outcomes for both individual (monopoly) and strategic (duopoly) settings.
Active Site Flexibility in Enzyme Catalysis a

Abstract: The inactivation of a number of enzymes during denaturation by physical and chemical factors precedes detectable global conformational changes of the molecules as monitored by conventional methods. It was suggested that the enzyme active site is more flexible and more sensitive to denaturation than the molecule as a whole. The well‐known “induced fit” hypothesis by Koshland implies multiconformational states of enzymes in equilibrium with one another easily perturbed by ligands. Each intermediary step during the entire catalytic process may require the molecule to be in a particular conformation state; rapid interconversion between the different conformation states may well be involved in the catalytic process. As a relative fragile and consequently flexible active site has now been envisaged, it appears that a rapid cycling of the different active site conformation states is essential for the full expression of enzyme activity.
The Textual Contents of Media Reports of Information Security Breaches and Profitable Short-Term Investment Opportunities

Information security-related incidents continue to make headlines. Interestingly, researchers have found mixed results when attempting to associate reports of information security breaches with changes in the affected firm's stock price. This research delves further into this puzzle by investigating the association between the textual contents of information security breach media reports and the stock price, as well as the trading volume reactions of the affected firm(s) around the breach announcement day. Our findings suggest that when the textual contents of breach reports provide more detailed information regarding the incidents, a more consistent belief is formed by the market about the negative impact of the reported security incident on the firm's business value. However, when there is a lack of specific information regarding the reported breach, the market does not seem to reach consensus on the impact of reported security incidents. We further demonstrate that different perceptions exist among general and sophisticated investors regarding the impact of reported information security incidents on a firm's future performance as demonstrated by changes in trading volume. By exploiting the different perceptions among investors, we form a trading strategy to demonstrate that, on average, one can make about 300% annual profit around the breach announcement day.
How to Choose the Sex of Your Baby

More Than 1.5 Million Copies Sold! Now Revised and Updated to Include the Latest Scientific Information and Even More Success Stories For almost forty years, How to Choose the Sex of Your Baby has been the standard reference for couples trying to increase their chances of having the son or daughter they hope for. In this new edition of their classic book, Dr. Shettles and David Rorvik provide authoritative scientific studies and compelling anecdotal evidence demonstrating that the Shettles method continues to produce results unmatched by any other method. Dozens of testimonials confirm its ease of use and rate of success. How to Choose the Sex of Your Baby explains the simple, at-home, noninvasive Shettles method and presents detailed steps to take to conceive a child of a specific gender. The properly applied Shettles method gives couples a 75 percent or better chance of having a child of the desired sex. Some researchers have reported success rates of up to 90 percent!
Neurovascular disease, antioxidants and glycation in diabetes

People with diabetes are ten to fifteen times more likely to have a lower limb amputation (LLA) than non‐diabetic individuals. Fifteen percent of people with diabetes will develop a foot ulcer during their lifetime, the rate of major amputation amongst diabetic individuals continues to rise, foot problems remain the commonest reason for diabetes‐related hospitalisation and recurrence rates in patients with previous foot ulcers are 50% or more. Hyperglycaemia‐induced oxidative stress has been shown to result in decreased nerve conduction velocity, and decreased endoneural blood flow—both precursors for neuropathy. Vitamin antioxidants have been shown to be effective therapy in experimental models in reducing free radical species and inhibiting the oxidative process in diabetes subjects. Little work has been published, however, regarding the dietary use of antioxidants from foods, and their specific effects on neurovascular disease and glycation within the diabetes population. Aetiological and prevention studies with dietary antioxidants from foods aimed at the complex nature of foot problems in diabetes are needed. Copyright © 2002 John Wiley & Sons, Ltd.
[Postnatal infant crying and maternal tiredness: examining their evolution and interaction in the first 12 weeks postpartum].

A new mother lazing in childbed is a blessing for her family” is an old Swiss proverb. Maternal rest and recuperation after birth was a common concern in the past and was frequently supported by the extended family. However, mothers today barely enjoy restful days after birth; instead they enter directly into the challenge of combining baby- and selfcare. They often struggle to soothe a crying baby, while coping with their own exhaustion, which can adversely affect family health. Surveys on maternal health consistently report tiredness and fatigue as the most frequent complaint postpartum, affecting 46%-87% of new mothers [1, 2]. Inconsolable infant crying is the most cited reason why parents consult health professionals [3]. To date little is known on how mothers confront and handle these challenges after birth. Routine postnatal care lacks effective strategies to alleviate the burden of infant crying and maternal tiredness which can adversely affect family health in the earliest stage. Following the traditional division between neonatal and maternal healthcare, research has usually focussed on conditions affecting either the mother or the neonate, but little attention has been given to the interplay of infant crying and maternal tiredness. While maternal tiredness after birth can be seen as normal reaction to the efforts of gestation and birth [4], maternal fatigue is more severe than tiredness, and can be defined as imbalance of activity and rest [5]. Whereas tiredness is naturally relieved in the circadian rhythm by periods of sleep, fatigue persists through the circadian rhythm, cannot be relieved through a single period of sleep, and is accompanied with a negative feeling [6]. Fatigue hampers the well-being of the affected person and is known as risk factor for the development of postpartum depression [7] and for a slightly less optimal development of the infants’ fine motor and coordinative skills [8]. Postnatal infant crying is currently regarded as a normal part of a child’s neuro-behavioural development following a typical curve which peaks during the sixth week postpartum at nearly 3 hours crying per day, and declines to below 1 hour per day by 12 weeks of age, with large inter-individual variation [9, 10]. Excessive crying is usually defined by ‘Wessel’s rule of three’. It lasts more than 3 hours on more than 3 days per week, and recurs for more than 3 weeks [3, 11]. Such crying behaviour is a known risk factor for the development of maternal postpartum depression, dysfunctional parent-child relation and, in extreme cases, for shaken baby syndrome or other forms of child abuse [12-14]. Our interest in the present research project was not limited to the pathologic forms of maternal fatigue and excessive crying, but embraced the entire continuum from physiologic maternal tiredness to fatigue, and from normal to excessive infant crying. If healthcare is to address the prominent concerns of parents caring for a neonate, we need a deeper understanding of how infant crying and…
The Application of Whole Cell-Based Biosensors for Use in Environmental Analysis and in Medical Diagnostics

Various whole cell-based biosensors have been reported in the literature for the last 20 years and these reports have shown great potential for their use in the areas of pollution detection in environmental and in biomedical diagnostics. Unlike other reviews of this growing field, this mini-review argues that: (1) the selection of reporter genes and their regulatory proteins are directly linked to the performance of celllular biosensors; (2) broad enhancements in microelectronics and information technologies have also led to improvements in the performance of these sensors; (3) their future potential is most apparent in their use in the areas of medical diagnostics and in environmental monitoring; and (4) currently the most promising work is focused on the better integration of cellular sensors with nano and micro scaled integrated chips. With better integration it may become practical to see these cells used as (5) real-time portable devices for diagnostics at the bedside and for remote environmental toxin detection and this in situ application will make the technology commonplace and thus as unremarkable as other ubiquitous technologies.
Reconstruction of femur length from markers of its proximal end

Length of femur and stature are of forensic and anthropological significance. Bony markers such as the head and neck of the femur can be of use in determining the femoral length when only a fragment of the proximal femur is available. A total of 171 South Indian unpaired femora, devoid of gross pathology and grouped by genders and sides, were used to measure the neck‐shaft angle, neck length, intertrochanteric apical axis length, maximum vertical diameter of the femur head, and maximum femur length. The data were statistically analyzed for regression. Length of femur significantly correlated with the other dimensions. Simple (linear) regression equations of the length of femur against the neck‐shaft angle, neck length, intertrochanteric apical axis length, and maximum vertical diameter of the head have been derived. The equations seem to be robust and can be used for different populations. © 1996 Wiley‐Liss, Inc.
A possible model for speciation by cytoplasmic isolation in the Culex pipiens complex.

Evidence so far available indicates that in the Culex pipiens complex there exists a genetic system with unique properties not comparable with those of the chromosomal gene system and probably involved in a mode of speciation peculiar to this complex. In a long series of backcrosses it has been shown that probably every Culex pipiens population contains a factor that is inherited through the cytoplasm, the only phenotypic expression of which is the crossability or non-crossability (incompatibility) of a given strain with other strains. That there is a whole series of such cytoplasmic factors is indicated by the twenty or so crossing types of Culex strains found throughout the world.In closed populations it seems likely that, as a result of genic diversification, a modification occurs that will eventually lead to differences in traits determined by genes.
Oxidative stress, inflammation and cardiovascular mortality in haemodialysis--role of seniority and intravenous ferrotherapy: analysis at 4 years of follow-up.

BACKGROUND Cardiovascular disease is the principal cause of morbidity and mortality in haemodialysis patients. The classic risk factors do not account for all cases of elevated cardiovascular disease in this patient population and it is becoming increasingly clear that other cardiovascular risk factors are implicated. The objective of this study was to analyse whether or not C-reactive protein (CRP) and plasma copper oxidized anti-lipoprotein (oxLDL) antibody titre are risk factors for cardiovascular mortality during 4 years of follow-up. METHODS A prospective follow-up study was carried out in 94 stable, chronic haemodialysis patients for 48 months (July 1999-July 2003) (gender: 50 males and 44 females; mean age: 67+/-14 years). Eighty-four per cent of these patients were receiving intravenous erythropoietin and 63% were receiving intravenous ferrotherapy (iron gluconate). Basal markers of inflammation and oxidative stress were determined at the beginning of the study. CRP levels were determined by chemiluminescent enzyme-labelled immunometric assay. The oxLDL antibody titre was measured by enzyme-linked immunosorbent assay using native LDL and oxLDL as antigens. RESULTS Fifty deaths occurred during the study, 66% (n = 33) of which were due to cardiovascular disease. Patients presented with basal CRP and oxLDL levels indicative of chronic inflammation and elevated oxidative stress [CRP median: 5.16 mg/l (25-75% percentile: 0.35-88.7 mg/l); oxLDL antibodies median: 153 (optical density at 495 nm x 1000) (25-75% percentile: 112-214)]. A positive correlation was found between CRP and age (r = 0.33, P = 0.003). Study of the risk factors demonstrated that age (P = 0.007), oxLDL antibody titre (P = 0.04) and albumin (P = 0.02) were the only predictors of cardiovascular mortality at 4 years of follow-up in this patient population. The Cox proportional hazards model for cardiovascular mortality showed that of the markers studied, oxLDL antibody titre was an independent risk factor for cardiovascular mortality. CONCLUSIONS Oxidative stress (oxLDL antibody titre) is one of the principal risk factors for cardiovascular mortality in this population of haemodialysis patients. Intravenous ferrotherapy, due to its pro-oxidant properties, probably favours oxidative stress. Serum concentration of CRP was not a good predictive factor of cardiovascular mortality during 4 years of follow-up, possibly because of the slight positive correlation that exists between CRP and age.
Molecular evidence of post–copulatory inbreeding avoidance in the field cricket Gryllus bimaculatus

Female promiscuity has broad implications for individual behaviour, population genetics and even speciation. In the field cricket Gryllus bimaculatus, females will mate with almost any male presented to them, despite receiving no recorded direct benefits. Previous studies have shown that female crickets can benefit from polyandry through increased hatching success of their eggs. There is evidence that this effect is driven by the potential of polyandrous females to avoid fertilizing eggs with sperm from genetically incompatible males. We provide direct evidence supporting the hypothesis that polyandry is a mechanism to avoid genetic incompatibilities resulting from inbreeding. Using microsatellite markers we examined patterns of paternity in an experiment where each female mated with both a related and an unrelated male in either order. Overall, unrelated males were more successful in gaining paternity than were related males, but this effect was driven by a much greater success of unrelated males when they were the first to mate.
Does sleep fragmentation impact recuperation?A review and reanalysis

Studies have shown that next‐day performance and alertness are impaired by sleep fragmentation procedures even when total sleep time (TST) is unaffected. Based on these studies it has been hypothesized that both the duration and continuity of sleep determine its recuperative value. This review of the literature suggests that when sleep fragmentation procedures increase the relative amount of stage 1 sleep, next‐day performance and alertness are impaired. Other studies suggest that stage 1 sleep has little or no recuperative value. Total sleep time, however, is typically defined as the sum of time spent in sleep stages 1, 2, 3, 4, and REM. In the present paper it is shown that when stage 1 sleep is excluded from TST, a stronger relationship between TST and subsequent alertness and performance emerges – and the need to invoke ‘sleep continuity’ as a variable that contributes independently to recuperative sleep processes is obviated. In the same way that partial or total sleep deprivation impairs alertness and performance, it is proposed that sleep disruption also impairs alertness and performance by reducing true recuperative sleep time.
Transgenic expression of a CD83‐immunoglobulin fusion protein impairs the development of immune‐competent CD4‐positive T cells

The murine transmembrane glycoprotein CD83 is an important regulator for both thymic T cell maturation and peripheral T cell response. CD83 deficiency leads to a block in the thymic maturation of CD4‐positive T cells, and interference with peripheral CD83/CD83 ligand interaction by addition of soluble CD83 suppresses immune responses in vivo and in vitro. Here we report the generation of a mouse transgenic for a fusion protein consisting of the extracellular domain of murine CD83 fused to the constant part of human IgG1 heavy chain. Thymic selection of CD4‐positive T cells was unchanged in CD83Ig transgenic and in CD83Ig/OT‐2 double‐transgenic mice. However, thymic and peripheral CD4‐positive T cells derived from CD83Ig/OT‐2 transgenic mice displayed a reduced cytokine response to antigenic stimulation in vitro, whereas CD83Ig/OT‐1‐derived CD8‐positive T cells showed normal cytokine secretion. The T cell defect was relevant in vivo, since a sub‐lethal infection with Trypanosoma cruzi led to an increased parasitemia and reduced survival rate of CD83Ig transgenic mice compared to wild‐type C57BL/6 mice. In contrast, in vivo application of recombinant CD83Ig did not result in an increase in parasitemia. Taken together our data suggest that thymic selection in the presence of CD83Ig leads to an intrinsic T cell defect of CD4‐positive T cells resembling the phenotype described for CD4‐positive T cells derived from CD83‐deficient mouse strains.
Clinical Results and Radiologic Findings Four to Eight Years after Total Hip Replacement with the Link RS Endoprosthesis System

A total of 102 uncemented Link Rippen System (RS) total hip prostheses were implanted in 100 patients whose mean age was 57 years. The Merle d'Aubigné hip score was 9.3 preoperatively and 15.3 at the latest follow-up. The thigh was painful in 56 per cent; 5 per cent had moderate or severe pain. Forty-five per cent of patients had a slight limp and 9 per cent a severe limp at the most recent follow-up. Fifteen per cent still needed a cane. A Kaplan-Meier survivorship analysis revealed a 74 per cent probability of survival at 6 years. Serial radiographic evaluations revealed that 16 per cent of patients (non-revised hips) had acetabular component migration, 10 per cent had continuous femoral radiolucen-cies, 14 per cent had subsidence and 31 per cent progressive varus migration.