Miracle-dz/UniFAR-FTUs huggingface dataset:
We are Social: a Social Influence Perspective to investigate Shadow IT Usage

Shadow IT can be used by one individual or a group of employees, which suggest two levels of use: an individual and collective use of shadow IT. The study takes a social influence perspective to investigate the mechanisms that underlie the dissemination process of shadow IT among users and uncover the reasons why they use shadow IT. We performed a survey among employees of four companies. The results show that the social influence varies depending on the group of reference in question (peer, superior, mass influence). We found that employees are strongly influenced by their peers and by a mass of people to use a shadow IT, such as co-workers, professional workmates, and employees from other departments, suggesting a broader range of social influence that can affect the use of shadow IT. We aid to clarify some reasons why employee uses shadow IT and how the dissemination process occurs among users. Also, as social influence is based on communication and social interactions, organizations may pay attention in creating initiatives and taking actions to engaged users in the information security policies, which is one of the primary concern related to shadow IT.
Identification of Casiopeina II-gly secondary targets through a systems pharmacology approach

Casiopeinas are a group of copper-based compounds designed to be used as less toxic, more efficient chemotherapeutic agents. In this study, we analyzed the in vitro effects of Casiopeina Il-gly on the expression of canonical biological pathways. Using microarray data from HeLa cell lines treated with Casiopeina II-gly, we identified biological pathways that are perturbed after treatment. We present a novel approach integrating pathway analysis and network theory: The Pathway Crosstalk Network. We constructed a network with deregulated pathways, featuring links between those pathways that crosstalk with each other. We identified modules grouping deregulated pathways that are functionally related. Through this approach, we were able to identify three features of Casiopeina treatment: a) Perturbation of signaling pathways, related to induction of apoptosis; b) perturbation of metabolic pathways, and c) activation of immune responses. These findings can be useful to drive new experimental exploration on their role in adverse effects and efficacy of Casiopeinas.
Regional differences in somatostatin receptor 2 (SSTR2) immunoreactivity is coupled to level of bowel invasion in small intestinal neuroendocrine tumors.

OBJECTIVE Somatostatin receptor (SSTR) expression constitutes a pivotal cornerstone for accurate radiological detection and medical treatment of small intestinal neuroendocrine tumors (SI-NETs), and the development of somatostatin analogues for these purposes have revolutionized the clinical work-up. Previous assessments of SSTR isoform expression in SI-NETs have found correlations to overall prognosis and treatment response, however these analyses usually report overall tumoral immunoreactivity, and little is reported regarding histo-regional differences in expressional patterns. METHODS Thirty-seven primary SI-NETs (WHO grade I, n=32 and WHO grade II, n=5) were collected and assessed for SSTR2 immunohistochemistry. Samples were stratified with regards to histological level of bowel infiltration and spread (mucosal region, muscularis propria region, subserosal region) and each of these tumoral regions was separately scored by SSTR2 staining localization (membrane, cytoplasmic), overall staining intensity and local staining differences within each region. RESULTS SSTR2 immunoreactivity was progressively weaker as the tumor cells advanced through the small intestinal layers. This was exemplified by a reduction in the amount of tumor samples with strong SSTR2 expression in the deeper histological levels of the section; 56% of tumors displayed strong SSTR2 expression in the mucosal region, as compared to 29% and 30% of tumors within muscularis propria and subserosal layers, respectively. CONCLUSIONS This observation indicates a down-regulation of SSTR2 expression as the tumors progress through the intestinal wall, which might signify underlying biological processes of importance for SI-NET invasion behavior.
A heterodimeric glutathione S-transferase that stereospecifically breaks lignin's β(R)-aryl ether bond reveals the diversity of bacterial β-etherases

Lignin is a heterogeneous polymer of aromatic subunits that is a major component of lignocellulosic plant biomass. Understanding how microorganisms deconstruct lignin is important for understanding the global carbon cycle and could aid in developing systems for processing plant biomass into valuable commodities. Sphingomonad bacteria use stereospecific glutathione S-transferases (GSTs) called β-etherases to cleave the β-aryl ether (β-O-4) bond, the most common bond between aromatic subunits in lignin. Previously characterized bacterial β-etherases are homodimers that fall into two distinct GST subclasses: LigE homologues, which cleave the β(R) stereoisomer of the bond, and LigF homologues, which cleave the β(S) stereoisomer. Here, we report on a heterodimeric β-etherase (BaeAB) from the sphingomonad Novosphingobium aromaticivorans that stereospecifically cleaves the β(R)-aryl ether bond of the di-aromatic compound β-(2-methoxyphenoxy)-γ-hydroxypropiovanillone (MPHPV). BaeAB's subunits are phylogenetically distinct from each other and from other β-etherases, although they are evolutionarily related to LigF, despite the fact that BaeAB and LigF cleave different β-aryl ether bond stereoisomers. We identify amino acid residues in BaeAB's BaeA subunit important for substrate binding and catalysis, including an asparagine that is proposed to activate the GSH cofactor. We also show that BaeAB homologues from other sphingomonads can cleave β(R)-MPHPV and that they may be as common in bacteria as LigE homologues. Our results suggest that the ability to cleave the β-aryl ether bond arose independently at least twice in GSTs and that BaeAB homologues may be important for cleaving the β(R)-aryl ether bonds of lignin-derived oligomers in nature.
Older HIV+ and HIV- Adults Provide Similar Definitions of Successful Aging: A Mixed-Methods Examination.

Background and Objective As HIV-infected (HIV+) individuals age, there is a need to understand successful aging (SA) from the patient perspective. This study compared SA definitions between HIV+ and HIV-uninfected (HIV-) older adults and then examined correlates of SA categories. Research Design and Methods Ninety-three HIV+ and 46 HIV- older (aged 50+) adults provided brief definitions of SA, which was examined using content analysis. We then compared the frequency of SA categories by serostatus and examined the correlates of SA categories within both groups. Results Seven SA categories emerged: General Health, Cognitive Health & Ability, Physical/Biological Health & Ability, Social Relationships, Attitudes, Psychological, & Emotional Well-Being, Proactive & Engaged Lifestyle, and Independence. While no significant differences emerged, HIV- older adults were more likely to report General Health and the subcategory of Longevity/Survival, while HIV+ older adults were more likely to report subcategories of Enjoying Life & Fulfillment and Maintaining Balance. Few demographic correlates of SA categories emerged. Mood and HIV characteristics were not associated with SA categories. In both groups, those without neurocognitive impairment were significantly more likely to endorse General Health than those with neurocognitive impairment. Discussion and Implications HIV+ and HIV- older individuals may generally perceive SA similarly, and their definitions parallel with existing models of SA. Yet, living with a chronic illness may cause HIV+ older adults to place greater value on quality of life and life satisfaction than physical health and chronological age. Observational and intervention studies may use similar approaches in evaluating and maximizing SA.
Evaluation of platelet parameters and neutrophil/lymphocyte ratio during omalizumab 
treatment in patients with severe chronic spontaneous urticaria

Background/aim Spontaneous wheals and/or angioedema lasting longer than six weeks are described as chronic spontaneous urticaria (CSU). Omalizumab is used for the treatment of antihistamine-resistant CSU. The neutrophil–lymphocyte ratio (NLR), platelet– lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) are considered important indicators of inflammation and platelet activation in chronic diseases. We aimed to determine the NLR, PLR, MPV, and PDW levels in patients with CSU compared with healthy controls. We also aimed to investigate the effects of omalizumab therapy on these parameters in CSU patients. Materials and methods This hospital-based, retrospective study included 143 patients with CSU and 132 healthy controls with a mean age of 40.0 ± 13.17 and 42.0 ± 16.34, respectively. Patients with equal or higher-than-baseline UAS scores at week 12 of omalizumab treatment were considered nonresponders, others were considered responders. We analyzed the neutrophils, lymphocytes, platelet counts, NLR, PLR, MPV, and PDW before, during, and after omalizumab treatment and compared the results with those of healthy controls. Results CSU patients presented higher baseline MPV (P = 0.035) and lower baseline PDW values (P < 0.001) than healthy controls. There were statistically significant increases in the MPV (P < 0.001), MPV/platelet count (P = 0.005), and PDW (P = 0.003) and there was a statistically significant decrease in the NLR (P = 0.018) during omalizumab treatment. The percent increase of MPV was low in nonresponders (P = 0.009). Nonresponders had lower PDW values than responders (P = 0.040). Conclusion The increase in the MPV and PDW may be due to platelet activation during omalizumab treatment. The decrease in the NLR may be regarded as an antiinflammatory effect of omalizumab. The effect of omalizumab on platelet and inflammatory markers may be used to discriminate the responders from nonresponders.
The effect of limited attention and delay on negative arousing false memories

ABSTRACT Previous research has shown that, in comparison to neutral stimuli, false memories for high arousing negative stimuli are greater after very fast presentation and limited attention at study. However, full compared to limited attention conditions still produce comparably more false memories for all stimuli types. Research has also shown that emotional stimuli benefit from a period of consolidation. What effect would such consolidation have on false memory formation even when attention is limited at study? The aim of the present study was to investigate the effect of fast presentation on false memory production for negatively-arousing and neutral items over time using the DRM paradigm. Sixty-eight participants studied Negative and neutral DRM lists with fast or slow presentation conditions. Half completed a recognition test immediately and half completed a recognition test after one-week. Results revealed that, for fast presentation, negative critical lures increased after one week and were comparable to negative critical lures in the slow presentation encoding conditions. Neutral critical lures in the fast presentation condition did not change and remained lower compared to the slow presentation condition. These findings are the first demonstration that arousing negative false memories can increase over time when attention at encoding is limited.
Baseplate variability of Vibrio cholerae chemoreceptor arrays

Significance The chemotaxis array is a macromolecular assembly employed by motile prokaryotes to sense their chemical environment. They share a universal architecture in which trimers of chemoreceptor dimers are arranged in a highly conserved hexagonal array. However, the cluster II arrays in Vibrio cholerae exhibit an underappreciated diversity in their composition. They have low structural stability despite the retention of the canonical receptor packing. Our results demonstrate that chemoreceptor arrays have an unexpectedly high variability in composition among species, a property that likely facilitates the rapid incorporation of different chemotaxis proteins in response to environmental changes. Overall, our results highlight the necessity to better understand chemoreceptor arrays and their biological significance outside the model organism. The chemoreceptor array, a remarkably ordered supramolecular complex, is composed of hexagonally packed trimers of receptor dimers networked by a histidine kinase and one or more coupling proteins. Even though the receptor packing is universal among chemotactic bacteria and archaea, the array architecture has been extensively studied only in selected model organisms. Here, we show that even in the complete absence of the kinase, the cluster II arrays in Vibrio cholerae retain their native spatial localization and the iconic hexagonal packing of the receptors with 12-nm spacing. Our results demonstrate that the chemotaxis array is versatile in composition, a property that allows auxiliary chemotaxis proteins such as ParP and CheV to integrate directly into the assembly. Along with its compositional variability, cluster II arrays exhibit a low degree of structural stability compared with the ultrastable arrays in Escherichia coli. We propose that the variability in chemoreceptor arrays is an important mechanism that enables the incorporation of chemotaxis proteins based on their availability.
La Pesca del corallo tra alti profitti e progetti inattuati (sec. XVIII)

Questo lavoro evidenzia l'importanza della pesca del corallo non solo a livello locale e regionale, ma nell'intera area mediterranea. Da questa e da altre numerose pubblicazioni emerge l'importanza della Sardegna in questa caratteristica pesca: si tratta di una vera e propria centralita derivante dalla qualita e dall'abbondanza del prodotto. L'importanza delle sue zone di pesca fece per secoli dell'isola il punto di riferimento di quel vasto complesso di interessi che, superando i contingenti egoismi regionali, trasformo il Mediterraneo ed i suoi porti in un mare aperto agli scambi, ai contatti, alle influenze di popoli spesso diversi; una vera e propria zona franca che mostra questo mare ed i paesi che si affacciano sulle sue rive come un'entita unitaria, inscindibile pur negli inevitabili contrasti.
Factors Influencing Enterprise Systems Procurement in Public Service Organisation: A Socio-Technical Case Study

Enterprise Systems (ES) are often presented as a driver for business by providing business process integration and utilisation of technology in organising. However, the majority of the ES research is centred on the implementation phase and pre-implementation and post-implementation phases remain largely ignored. Another gap in the existing literature is that it usually ignores the implementation context in theorising. This study focuses on the procurement process of a public service organisation and analyses three instances of ES procurement in the case organisation. The data collection and analysis are conducted using the theoretical lens of socio-technical systems (STS) theory. It notes that while the work-system level and organisation-system level factors play some role in the ES procurement, macrosocial level factors (institutional context and the ES market) play a more important role in the public service context. It also notes the demonstrative nature of certain elements of the ES procurement process in public service organisations. In this way, this study brings out the complexity of ES procurement in public service organisations that result from the interplay of factors operating at worksystem, organisational, and macro levels.
Submucous cleft palate: from diagnosis to management

Background/aim The aim of this study was to investigate submucous cleft palate (SMCP) patients in order to document the age of diagnosis, cause of referral, symptoms and palate findings, objective evaluation of nasalance and velopharyngeal dysfunction (VPD), and intervention type. Material and methods The archive of Hacettepe University Cleft Lip and Palate, Craniomaxillofacial Anomalies Research, Treatment, and Application Center was reviewed retrospectively, and 166 patients diagnosed with SMCP were documented. Results The mean age of the patients at the time of initial referral was 10 years and 3 months ± 8 years and 5 months with the youngest being 1 month and the oldest 44 years old. The primary complaint of 127 (76.5%) patients was speech disorder. Seventy-nine patients underwent surgery, and the mean age was determined as 10 years ± 6 years and 8 months. Conclusion The diagnosis of SMCP continues to be rather late, being delayed until a prominent speech disorder is present. Studies for the awareness of health professionals are of great importance for the early diagnosis and intervention of SMCP in order to prevent adverse effects.
Reassessment of Routine Midstream Culture in Diagnosis of Urinary Tract Infection

Midstream urine (MSU) culture remains the gold standard diagnostic test for confirming urinary tract infection (UTI). We previously showed that patients with chronic lower urinary tract symptoms (LUTS) below the diagnostic cutoff on MSU culture may still harbor bacterial infection and that their antibiotic treatment was associated with symptom resolution. ABSTRACT Midstream urine (MSU) culture remains the gold standard diagnostic test for confirming urinary tract infection (UTI). We previously showed that patients with chronic lower urinary tract symptoms (LUTS) below the diagnostic cutoff on MSU culture may still harbor bacterial infection and that their antibiotic treatment was associated with symptom resolution. Here, we evaluated the results of the United Kingdom’s MSU culture in symptomatic patients and controls. Next, we compared the bacterial enrichment capabilities of the MSU culture with those of a 50-µl uncentrifuged culture, a 30-ml centrifuged sediment culture, and 16S rRNA gene sequencing. This study was conducted on urine specimens from 33 LUTS patients attending their first clinical appointment (mean age, 48.7 years; standard deviation [SD], 16.5 years), 30 LUTS patients on treatment (mean age, 47.8 years; SD, 16.5 years) whose symptoms had relapsed, and 29 asymptomatic controls (mean age, 40.7 years, SD, 15.7 years). We showed that the routine MSU culture, adopting the UK interpretation criteria tailored to acute UTI, failed to detect a variety of bacterial species, including recognized uropathogens. Moreover, the diagnostic MSU culture was unable to discriminate between patients and controls. In contrast, genomic analysis of urine enriched by centrifugation discriminated between the groups, generating a more accurate understanding of species richness. In conclusion, the United Kingdom’s MSU protocol misses a significant proportion of bacteria, which include recognized uropathogens, and may be unsuitable for excluding UTI in patients with LUTS.
A Conventionalist Perspective On Information Security Policies in Organisations

Concern for information security is a major driver for policy implementation, and with new regulations like the General Data Protection Regulation, almost all types of organisations face the challenge of implementing and applying information security policies. Information security standards guide these processes, but the challenge of ensuring compliance is still a major issue, despite extensive information security research in this aspect. The lack of versatility in theoretical approaches led to calls for sociological approaches to contribute to the literature, but they were only partly addressed. The proposed framework of convention theory can serve as a fruitful approach, providing a pragmatic and contextualized perspective and a strong theoretical foundation from sociology. By adopting a conventionalist view of information security policies, attention is focused on issues of legitimacy without limiting the analysis to a solely structuralist perspective. This research in progress tries to take first steps in building a conventionalist framework for case-based research by introducing some of the main concepts of convention theory and illustrates possible implications for information security research and practice.
Communicating information on nature-related topics: Preferred information channels and trust in sources

How information is communicated influences the public’s environmental perceptions and behaviors. Information channels and sources both play an important role in the dissemination of information. Trust in a source is often used as a proxy for whether a particular piece of information is credible. To determine preferences for information channels and trust in various sources for information on nature-related topics, a mail-out survey was sent to randomly selected U.S. addresses (n = 1,030). Diverse groups of people may have differing communication preferences. Therefore, we explored differences in channel preferences and trust by demographics using regression models. Overall, the most preferred channels were personal experience, reading online content, and watching visual media online. The most trusted sources were science organizations, universities, and friends/family. Channel preferences varied the most by education level and age, while source trust was most influenced by education, race, age, and size of current residence (rural-urban). The influence of demographics varied depending on the individual channel and source, with some groups preferring certain channels or sources but not others. Results are useful to consider when disseminating information on nature-related topics to a general public audience. More broadly, results also suggest spreading information using different channels and sources depending on the specific audience being targeted.
Noise Trader Behavior - A Disaggregated Approach to Understanding News Reception in Financial Markets

Financial disclosures serve as primary intermediaries between companies and investors. However, investors have different information processing skills and might easily be misled by noisy signals that lack a deeper meaning. In financial markets, this is formalized by the noise trader theory, which groups investors into two categories: (a) informed investors assumed to form rational decisions and (b) noise traders forming beliefs partly based on non-fundamental noise signals and news sentiment. Yet, little is known about how these groups actually interpret textual information in financial statements and how the resulting stock market reaction differs. This work extends previous research by unraveling the role of word choice and semantic orientation in financial disclosures for both investor types. For this purpose, we use Kalman filtering to decompose the stock market reaction following the publication of U.S. regulated Form 8-K filings into a fundamental price component and a noise residual. We then use LASSO regression to identify the statistically relevant words for informed investors and noise traders. According to our results, each investor type assigns significantly different interpretations and degrees of importance to individual words and documents.