Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural Sign Language Translation based on Human Keypoint Estimation

We propose a sign language translation system based on human keypoint estimation. It is well-known that many problems in the field of computer vision require a massive dataset to train deep neural network models. The situation is even worse when it comes to the sign language translation problem as it is far more difficult to collect high-quality training data. In this paper, we introduce the KETI (Korea Electronics Technology Institute) sign language dataset, which consists of 14,672 videos of high resolution and quality. Considering the fact that each country has a different and unique sign language, the KETI sign language dataset can be the starting point for further research on the Korean sign language translation. Using the KETI sign language dataset, we develop a neural network model for translating sign videos into natural language sentences by utilizing the human keypoints extracted from the face, hands, and body parts. The obtained human keypoint vector is normalized by the mean and standard deviation of the keypoints and used as input to our translation model based on the sequence-to-sequence architecture. As a result, we show that our approach is robust even when the size of the training data is not sufficient. Our translation model achieved 93.28% (55.28%, respectively) translation accuracy on the validation set (test set, respectively) for 105 sentences that can be used in emergency situations. We compared several types of our neural sign translation models based on different attention mechanisms in terms of classical metrics for measuring the translation performance.
Critical thinking skills: The academic ability, mastering concepts and analytical skill of undergraduate students

Science and technology development in the 21st-century has been demanding educators to provide learning activities which stimulate students’ critical thinking skills. This study aimed to find out the correlated factors of the students’ critical thinking skills as well as of which was the strongest determinant in leveling the skills. The subject of this correlational research was 112 undergraduate students in the Department of Biology Education, Universitas Muhammadiyah Malang who took Botany course. There were four variables measured in this study, namely academic ability, mastering concepts, analytical skill, and critical thinking skills. The data of academic ability was obtained from students' cumulative index in the previous semester while the three other variables were measured using final exam test. All of the variables then analyzed using multiple linear regression. The results showed that the three predictor variables (mastering concepts, academic ability, and analytical skill) gave effective contributions toward students’ critical thinking skills, with the percentages of 3.84%, 32.25%, and 54.26% respectively. Therefore, the results of this study could be a basic reference in designing learning process which empower the students’ critical thinking skills.
DAPSA and ultrasound show different perspectives of psoriatic arthritis disease activity: results from a 12-month longitudinal observational study in patients starting treatment with biological disease-modifying antirheumatic drugs

Objectives Disease Activity index for PSoriatic Arthritis (DAPSA) (sum score 68/66 tender/swollen joint counts (68TJC/66SJC), patient’s global assessment, pain and C-reactive protein (CRP)) is recommended for clinical assessment of disease activity in patients with psoriatic arthritis (PsA). Ultrasound (US) (grey scale (GS) and power Doppler (PD)) detects inflammation in joints and extra-articular structures. The present objectives were to explore the longitudinal relationships between DAPSA, clinical assessment as well as patient-reported outcome measures (PROMs) with US in patients with PsA initiating biological DMARDs and the associations between DAPSA and US remission. Methods 47 patients with PsA were examined at baseline and after 3, 6, 9 and 12 months. Assessments included 68TJC/66SJC, examiner’s global assessment (EGA), PROMs, CRP, erythrocyte sedimentation rate (ESR) and US GS and PD (48 joints, 10 flexor tendons, 14 entheses, 4 bursae). Clinical composite scores and PD sum scores (0=remission) were calculated. Longitudinal associations were explored by generalised estimating equations with linear and logistic regression. Results DAPSA was not longitudinally associated to PD. 66SJC, ESR, 28-joint Disease Activity Score, EGA and CRP were longitudinally associated with PD (p<0.001–0.03), whereas the pain-related components of DAPSA (68TJC and pain) as well as PROMs were not associated. At 6–12 months, remission was achieved in 29%–33 % of the patients for DAPSA and 59%–70 % for PD. The association between DAPSA and PD remission was not significant (p=0.33). Conclusions DAPSA was not associated with US inflammatory findings which indicates that DAPSA and US may assess different aspects of PsA activity.
A Population-Based (Super-Child) Approach for Predicting Vitamin A Total Body Stores and Retinol Kinetics in Children Is Validated by the Application of Model-Based Compartmental Analysis to Theoretical Data

Abstract Background Public health nutritionists need accurate and feasible methods to assess vitamin A status and to evaluate efficacy of interventions, especially in children. The application of population-based designs to tracer kinetic data is an effective approach that reduces sample burden for each child. Objectives Objectives of the study were to use theoretical data to validate a population-based (super-child) approach for estimating group mean vitamin A total body stores (TBS) and retinol kinetics in children and to use population-based data to improve individual TBS predictions using retinol isotope dilution (RID). Methods We generated plasma retinol kinetic data from 6 h to 56 d for 50 theoretical children with high vitamin A intakes, assigning values within physiologically reasonable ranges for state variables and kinetic parameters (“known values”). Mean data sets for all subjects at extensive (n = 36) and reduced (n = 11) sampling times, plus 5 data sets for reduced numbers (5/time, except all at 4 d) and times, were analyzed using Simulation, Analysis and Modeling software. Results were compared with known values; population RID coefficients were used to calculate TBS for individuals. Results For extensive and reduced data sets including all subjects, population TBS predictions were within 1% of the known value. For 5 data sets reflecting numbers and times being used in ongoing super-child studies, predictions were within 1–17% of the known group value. Using RID equation coefficients from population modeling, TBS predictions at 4 d were within 25% of the known value for 66–80% of subjects and reflected the range of assigned values; when ranked, predicted and assigned values were significantly correlated (Rs = 0.93, P < 0.0001). Results indicate that 7 d may be better than 4 d for applying RID in children. For all data sets, predictions for kinetic parameters reflected the range of known values. Conclusion The population-based (super-child) approach provides a feasible experimental design for quantifying retinol kinetics, accurately estimating group mean TBS, and predicting TBS for individuals reasonably well.
Should He Stay or Should He Go? Estimating the Effect of Firing the Manager in Soccer

To do such an analysis, we need data about the firing or sacking of managers and about the performance of football teams. I use data from the top two English soccer leagues. Based on anecdotal evidence, the English league is not the "most dangerous" for managers; there are other leagues where sackings are more frequent. It is, however, the only league in which the amount of data accessible to us makes it possible to do "statistical analysis" rather than "case studies. " Results offootball matches. These are easy to quantify.The results (and dates) of all matches can be obtained either from Rothmans Football Yearbook (RFY), bought in computer readable formor found (forrecent seasons) on the Internet. Directing your browser to the home page of The Association of FootballStatisticians (www.innotts.co.uk/soccerstats! ) is a good way to start. A match Rt B R L M1ddlubrough bou. 8r')W1Rob'on . ' he" tt,. , g to penYld.lhe foolbll At,oaetIonto rethri ttl.IoIIOC. on yeIIwen4re4Ufd, lIIC«u.tdlnre,ervele.tmmetcht1 . He". d "1I:) hw1hbee,u.sekds. mo do get booled r'l reservegem" c.wIl nus Il'TlIIIfchnth. ,ut1'Vt,•. "dlhen I>ec*tyforlhe rnt t eem. lothtyp~hyou. " bolh. ,. , · . ,. ,. "
Bioavailability and Disposition of the Bioactive Food Component D-Limonene, and Implications for Breast Cancer Prevention

d-Limonene is a monoterpene found in high concentration in citrus peel oil. Evidence from animal models and cell culture indicate that it has strong anti-cancer effects, particularly in mammary cancer models. Chapter 1; “D-LIMONENE: A BIOACTIVE FOOD COMPONENT FROM CITRUS AND EVIDENCE FOR A POTENTIAL ROLE IN BREAST CANCER PREVENTION AND TREATMENT” is a review paper accepted to Oncology Reviews. This review describes the evidence for d-limonene’s anti-cancer mechanisms, bioavailability and safety, focusing on relevance to breast cancer prevention. Chapter 2; “ADIPOSE TISSUE ACCUMULATION OF D-LIMONENE WITH THE CONSUMPTION OF A LEMONADE PREPARATION RICH IN D-LIMONENE CONTENT” is published in Nutrition and Cancer journal and describes a phase I clinical trial in which participants consumed 40 oz of high-limonene lemonade daily. This study demonstrated that after 4 weeks of oral consumption of high-limonene lemonade, d-limonene deposits in high levels in adipose tissue. Chapter 3; “A CLINICAL BIOMARKER STUDY OF TOPICALLY APPLIED D-LIMONENE FOR BREAST CANCER PREVENTION” was submitted to Nutrition and Cancer journal. In this phase 0 clinical study, four weeks of a 10% d-limonene formulation resulted in minimal change in NAF and plasma biomarkers or d-limonene levels. Biomarkers in NAF and plasma, however, were significantly differently correlated with BMI and menopausal status, perhaps suggesting effect modifications. Chapter 4: “MOUSE MAMMARY TISSUE DISTRIBUTION OF D-LIMONENE AND PERILLIC ACID FOLLOWING ORAL AND TOPICAL DLIMONENE ADMINISTRATION,” was a study comparing d-limonene and perillic acid disposition after administration of 10% and 20% d-limonene in coconut oil in topical and
Symptom clusters among cancer patients and effects of an educational symptom control intervention

Summary An abundance of research has observed that patients with cancer experience multiple concurrent symptoms, and recent research suggests that certain clusters of symptoms may have a synergistic effect on one another and on future patient outcomes. In this study we first identified relevant symptom clusters for a sample of cancer patients, and then tested the effectiveness of an educational symptom control intervention in reducing the severities of these symptom clusters. Finally, we investigated whether the symptom control intervention had a carry-over effect on utilization of physician, hospital and emergency room services. Two hundred twenty-two patients diagnosed with a solid tumor (breast, lung, other) and undergoing the first two cycles of their first course of chemotherapy were recruited and randomly assigned to an intervention group (N=110) or a control group receiving usual care (N=112). From the fifteen cancer-related symptoms under consideration, a factor analysis identified three important symptom clusters: cluster A (nausea, vomiting, diarrhea, poor appetite), cluster D (insomnia, pain, fatigue) and cluster E (difficulty breathing, cough). The intervention proved to be effective in reducing severities for symptom cluster D, as well as reducing the number of hospitalizations. The results of this study provided valuable insight into symptom clusters associated with cancer and its treatment, and revealed that the well recognized pain, fatigue, insomnia cluster was favorably impacted by the educational intervention. On the clinical level, the results suggest that physicians and oncology nurses should think in terms of these naturally clustering symptoms when recommending plans for symptom management, in order to be more effective in the overall management of a larger spectrum of symptoms.
Determinação simplificada de carbamazepina, fenitoína, fenobarbital e lamotrigina em plasma e monitoração terapêutica por HPLC/PDA

Carbamazepina, fenitoina, fenobarbital e lamotrigina sao bem conhecidos como farmacos anticonvulsivantes usados para o tratamento da epilepsia. A utilizacao destes farmacos e associada a varias reacoes adversas, tornando necessario o controle terapeutico. Os ensaios foram realizados por meio de cromatografia liquida de alta eficiencia e o metodo de extracao utilizado foi o liquido-liquido. Os farmacos e o padrao interno de zolpidem foram separados por uma coluna de fase reversa (ACE 5, C18 150 x 4,6 mm d.i.). A fase movel constituida de acetonitrila (30%) e acido citrico/tampao fosfato pH 5,0 (70%) foi utilizada sob gradiente de fluxo de 0,7 a 1,2 mL/min e o comprimento de onda utilizado para a deteccao dos analitos foi fixado em 210 nm. A tecnica apresentou linearidade ao longo do intervalo de 0,5 a 20,0 µg/mL para carbamazepina/lamotrigina e de 2,0 a 64,0 µg/mL, para fenitoina/ fenobarbital com coeficiente de correlacao linear maior que 0,98. As amostras de sangue foram obtidas de pacientes adultos com diagnostico de epilepsia em acompanhamento no Ambulatorio Municipal de Psiquiatria de Goiânia. A media de recuperacao obtida foi de 96,8% a 108,5% para carbamazepina/lamotrigina e de 93,8% a 108,8% para a fenitoina/fenobarbital. Os limites de quantificacao, precisao (CV 85,0 %) demonstraram estar em conformidade com as exigencias da ANVISA. Nove pacientes foram avaliados para confirmar a validade do metodo. Palavras-chave:Anticonvulsivantes. Monitoracao terapeutica de farmacos. HPLC. ABSTRACT Simplified determination of carbamazepine, phenytoin, phenobarbital and lamotrigine in plasma and therapeutic monitoring by HPLC/PDA Carbamazepine, phenytoin, phenobarbital and lamotrigine are well known anticonvulsant drugs used in the treatment of epilepsy. However, these medications are associated with side effects and therefore require therapeutic monitoring. Blood samples of adult outpatients diagnosed with epilepsy at the Goiânia Municipal Psychiatry Clinic (Brazil) were collected and analyzed using high-performance liquid chromatography. The analytes and internal standard (zolpidem) were extracted by liquid-liquid extraction. A reversed phase column (ACE 5, C18, 150 x 4.6 mm i.d.) was used. The mobile phase was composed of acetonitrile (30%) and citric acid/phosphate buffer, pH 5.0 (70%). The gradient flow rate was from 0.7 to 1.2 mL/min and the detection wavelength was set at 210 nm for all analytes. The analysis revealed a linear range from 0.5 to 20.0 µg/mL for carbamazepine/lamotrigine and 2.0 to 64.0 µg/mL for phenytoin/phenobarbital. Mean recovery ranged from 96.8% to 108.5% for carbamazepine/lamotrigine and 93.8% to 108.8% for phenytoin/phenobarbital. The quantification limit, precision (CV 85%) proved to be in accordance with the requirements stipulated by the Brazilian National Health Surveillance Agency (ANVISA). Nine outpatients were evaluated to confirm the validity of the method. Keywords: Anticonvulsant. Therapeutic drug monitoring. HPLC.
The Intermediate Data Structure (IDS) for Longitudinal Historical Microdata, version 4

The Intermediate Data Structure (IDS) is a standard data format that has been adopted by several large longitudinal databases on historical populations. Since the publication of the first version in Historical Social Research in 2009, two improved and extended versions have been published in the Collaboratory Historical Life Courses. In this publication we present version 4 which is the latest ‘official’ standard of the IDS. Discussions with users over the last four years resulted in important changes, like the inclusion of a new table defining the hierarchical relationships among ‘contexts,’ decision schemes for recording relationships, additional fields in the metadata table, rules for handling stillbirths, a reciprocal model for relationships, guidance for linking IDS data with geospatial information, and the introduction of an extended IDS for computed variables.
Identification de facteurs de risque d'insuffisance rénale en trauma

Background: Acute kidney injury (AKI) has important mortality and morbidity complications. Few studies have looked at predictors of acute renal failure in a trauma patient population. Objectives: We sought to identify factors associated with AKI that can be assessed in the early hospital stay of trauma patients. We also specifically assessed if the administration of radiological contrast was a predictor of AKI. Methods: We conducted a nested case-control study from the trauma registry of an urban Level I trauma center which includes data on more than 6000 subjects. The cases consisted of 49 patients with a diagnosis of AKI by their treating physician in the first 7 days following their trauma between 2002 and 2006. The controls were randomly selected for a 1:2 case to control ratio. Data were retrieved from the prospective trauma registry database. Additional data were also obtained via the hospital laboratory and radiology databases. Finally, a structured chart review was conducted to obtain the remaining information. Univariate analyses were conducted. Elements with a significance level of <0.1 were included in a multivariate logistic regression model. Results: Predictors identified in the univariate analysis were: the first creatinine value obtained (p<0,001), hemodynamic instability (p<0,001), history of coronary artery disease (p=0,007), history of chronic renal insufficiency as per physician’s diagnosis in the chart (p=0,009), surgery in the 48 hours following the trauma (p=0,053), and, injection of contrast in the 48 hours following the trauma (p=0,077). In the final multivariate model, two factors were statistically significant. One factor was the first creatinine value p<0.001, OR 6,17 CI95 % (2,81 – 13,53) for each increase of creatinine by 0,5mg/dL. The other factor was the presence of hemodynamic instability p<0.001 OR 11,61 CI95 % (3,71 – 36,29). Conclusion: Easily obtained information in the emergency department can aid in predicting the risk of AKI in a trauma population. Early administration of radiological contrast was not an independant predictor of AKI in this population.
Does Signaling Help Professional Programmers Read and Understand Computer Programs

Signaling refers to the addition of non-content information to a text in order to emphasize certain ideas and/or clarify the organization. There is increased interest in using typographic signaling, such as boldface type, different font sizes and ruled lines, to format computer program source code listings. However, little evidence exists to show that this type of formatting makes programs easier to read and understand. The present study reports on a controlled experiment which investigated the effectiveness of typographic signaling, header comments before modules, and mnemonic module names as ways to aid comprehension. We found that while all three factors helped experienced programmers confirm hypotheses about a 913-line program, only the header comments and mnemonic names helped the programmers locate material in the program. We also found only modest improvements in comprehension when typographic signaling was used with header comments and mnemonic names.
Professional Use of the Internet by Physical Therapists in Michigan

Purpose. The impact of the Internet on health care is growing, therefore emphasizing the need for physical therapists to become knowledgeable about using and evaluating this technology as a source of information. As the profession of physical therapy moves toward online education and evidence‐based practice, skill in the use of the Internet will be essential. While clinicians have always been encouraged to use the latest research in clinical practice, the Internet makes access to that information immediate. The purpose of this descriptive study was to determine access, current skill, criteria used to evaluate Web sites, and professional use of the Internet by physical therapists in Michigan. Methods. Five hundred licensed physical therapists from the three largest counties in Michigan were randomly selected to participate. One hundred ninety‐three surveys were completed and returned (38.6% response rate). Results. Sixty percent of physical therapists reported they have Internet access at work, with physical therapists working in public schools reporting the greatest access. Fifty‐three percent reported they had little experience in using the Internet for professional purposes. The most commonly used professional resource was MEDLINE (45.5%). The top criteria used to evaluate the quality of information found on the Internet were personal knowledge (61%) and site sponsorship (39.5%). Conclusions. This study suggests a need to increase the knowledge and comfort of physical therapists in using and evaluating the Internet for professional purposes.
Systematic program evaluation of online nursing education at the master’s degree leve

Online education is a relatively recent innovation in nursing education and warrants being evaluated for its effectiveness and impact on teaching and learning. The purpose of this study was to investigate current practice and use of systematic program evaluation of master’s degree level online education in schools of nursing. An 84 item questionnaire was developed to measure: (1) to what extent are schools of nursing systematically evaluating their online education activities at the master’s degree level; (2) what are the sources of evaluation data; (3) what are the areas of evaluation; (4) to what extent are the evaluation results utilized in schools of nursing; and (5) to what extent do institutional and program characteristics affect evaluation. The population sample included 383 schools of nursing with master’s degree level programs accredited by the National League for Nursing Accrediting Commission and the Commission on Colleges in Nursing Education. One hundred seven (107/31%) schools of nursing responded to the Internet or mail and paper survey. Using frequencies, means, standard deviations, and simple bivariate analysis, data analysis showed the most common source of evaluation data is from students (M = 2.80). Respondents reported evaluation practices focused on process most frequently than any other area (M = 2.63). Frequency results indicated that all utilization activities were being done to some extent of agreement, that is, no respondents reported zero for any response. Finally, more mature master’s degree level nursing programs are more apt to seek a variety of sources of evaluation data. Four conclusions are drawn from this study. First, systematic program evaluation appears to be a pervasive practice in schools of nursing. Second, there is a discrepancy between espoused utilization of evaluation data and reported practices related to the predominant source of evaluation data (students) and primary focus of evaluation (process). Third, two major stakeholder groups, employers who hire program graduates and staff members who help implement the program, are not included in program evaluation practices and utilization activities. Finally, use of two program evaluation approaches to frame and conceptualize the study resulted in a comprehensive and coherent measurement of evaluation practice and utilization. INDEX WORDS: Evaluating online education, web-enhanced nursing education, web-based nursing education, utilization-focused evaluation, CIPP program evaluation model SYSTEMATIC PROGRAM EVALUATION OF ONLINE NURSING EDUCATION AT THE MASTER’S DEGREE LEVEL: CURRENT PRACTICES