Miracle-dz/UniFAR-FTUs huggingface dataset:
Coping and parenting: Mediators of 12-month outcomes of a family group cognitive-behavioral preventive intervention with families of depressed parents.

OBJECTIVE In a randomized clinical trial with 111 families of parents with a history of major depressive disorder (86% mothers, 14% fathers; 86% Caucasian, 5% African-American, 3% Hispanic, 1% American Indian or Alaska Native, 4% mixed ethnicity), changes in adolescents' (mean age = 11 years; 42% female, 58% male) coping and parents' parenting skills were examined as mediators of the effects of a family group cognitive-behavioral preventive intervention on adolescents' internalizing and externalizing symptoms. METHOD Changes in hypothesized mediators were assessed at 6 months, and changes in adolescents' symptoms were measured at a 12-month follow-up. RESULTS Significant differences favoring the family intervention compared with a written information comparison condition were found for changes in composite measures of parent-adolescent reports of adolescents' use of secondary control coping skills and direct observations of parents' positive parenting skills. Changes in adolescents' secondary control coping and positive parenting mediated the effects of the intervention on depressive, internalizing, and externalizing symptoms, accounting for approximately half of the effect of the intervention on the outcomes. Further, reciprocal relations between children's internalizing symptoms and parenting were found from baseline to 6-month follow-up. CONCLUSION The present study provides the first evidence for specific mediators of a family group cognitive-behavioral preventive intervention for families of parents with a history of major depressive disorder. The identification of both coping and parenting as mediators of children's mental health outcomes suggests that these variables are important active ingredients in the prevention of mental health problems in children of depressed parents.
Modelización geomecánica de los procesos de densificación, licuefacción y movilidad cíclica de suelos granulares sometidos a solicitaciones dinámicas

Las propiedades de los suelos sufren modificaciones de consideracion cuando estos se ven sometidos a solicitaciones de tipo dinamico. Los modelos constitutivos que reproducen correctamente el comportamiento de los suelos en situaciones estaticas se tornan incapaces de predecir como evolucionan las tensiones y las deformaciones cuando las cargas aplicadas son variables en el tiempo. Sin embargo, las solicitaciones dinamicas con mucho mas frecuentes que las estaticas en la naturaleza. Las situaciones mas dramaticas se experimentan en los terremotos, donde los suelos sufren grandes deformaciones que alteran enormemente sus caracteristicas, y donde el agotamiento estructural sufrido por las geoestructuras, la disminucion de la capacidad portante en las cimentaciones, y las avalanchas producidas en laderas montanosas producen en cada uno de estos desgraciados episodios la perdida de multitud de vidas humanas y de bienes materiales. Los modelos constitutivos cuya finalidad es analizar este tipo de problemas no son sencillos en absoluto. Su complejidad se incrementa ademas con la presencia de agua en contacto con las particulas solidas. En ese caso, los modelos deben representar al comportamiento de cada una de las fases coexistentes en el suelo, asi como la interaccion entre ellas. En eta tesis doctoral se ha realizado un modelo numerico para representar el comportamiento dinamico de los suelos granulares no cohesivos. Las interacciones de tipo quimico y termodinamico no son consideradas en esta nueva herramienta, que unicamente tiene encuentra relaciones de tipo mecanico entre los diferentes componentes del suelo. Este nuevo modelo es capaz de reproducir condiciones extremas de saturacion el suelo; totalmente seco o totalmente saturado. Existen multitud de modelos con la misma finalidad que el aqui desarrollado. La mayor parte de ellos, sin embargo, se basan en teorias plasticas, y requieren la calibracion de
Association of Wilms Tumor with Spinal Dysraphism

Previous data suggested an association of vertebral anomalies with Wilms tumor. At the same time, vertebral midline fusion defects are often indicated by dermal anomalies over the spine. In the present study the prevalence of both occult spina bifida and cutaneous signs of spinal dysraphism was significantly higher in 50 Wilms patients than in 180 control children (18.0 versus 4.4%, p < .01, and 35.9 versus 17.5%, p < .02, respectively). Family investigations are needed to answer the question whether signs of spinal dysraphism in parents and sibs of patients may be regarded as indicators of an increased risk of Wilms tumor in the family.
Glutathione S-Transferase Isoenzymes from Streptomyces griseus

ABSTRACT An inducible, cytosolic glutathione S-transferase (GST) was purified from Streptomyces griseus. GST isoenzymes with pI values of 6.8 and 7.9 used standard GST substrates including 1-chloro-2,4-dinitrobenzene. GST had subunit and native Mrs of 24 and 48, respectively, and the N-terminal sequence SMILXYWDIIRGLPAH.
Research methodologies for complex ecosystems: enhancing the societal value of IS

Societal ecosystems are struggling to solve complex problems that could benefit from research by information systems (IS) scholars. However, existing IS research methodologies seek to reduce complexity and so are unsuited to the holistic investigation of complex phenomena. This paper presents a research methodology based on principles of complexity theory consisting of three non-linear phases, namely sensemaking, action and reflection. This complexity-aware methodology requires innovative methods of data collection, analysis and presentation. In order to demonstrate the application of the methodology, an action research project, which investigates the complex challenge of enabling elderly citizens to use IS for social wellbeing, is described. Thus, in addition to the methodological contribution, the results of this IS research provide an instance where IS can contribute to enhanced societal value.
The Relationship between Religious Activities and Blood Pressure in Older Adults

Objective: To examine the relationship between religious activities and blood pressure in community-dwelling older adults. Method: Blood pressure and religious activities were assessed in a probability sample of 3,963 persons age sixty-five years or older participating in the Duke EPESE survey. Participants were asked if their doctor had ever informed them that they had high blood pressure and if they were currently taking medication for high blood pressure. After the interview, systolic and diastolic blood pressures were measured following a standardized protocol. Data were available for three waves of the survey (1986, 1989–90, and 1993–94). Analyses were stratified by age (65–74 vs. over 75) and by race (Whites vs. Blacks) and were controlled for age, race, gender, education, physical functioning, body mass index, and, in longitudinal analyses, blood pressure from the previous wave. Results: Cross-sectional analyses revealed small (1–4 mm Hg) but consistent differences in measured systolic and diastolic blood pressures between frequent (once/wk) and infrequent (< once/wk) religious service attenders. Lower blood pressures were also observed among those who frequently prayed or studied the Bible (daily or more often). Blood pressure differences were particularly notable in Black and younger elderly, in whom religious activity at one wave predicted blood pressures three years later. Among participants who both attended religious services and prayed or studied the Bible frequently, the likelihood of having a diastolic blood pressure of 90 mm Hg or higher was 40 percent lower than found in participants who attended religious services infrequently and prayed or studied the Bible infrequently (OR 0.60, 95% CI, 0.48–0.75, p < .0001). Among participants told they had high blood pressure, religiously active persons were more likely to be taking their blood pressure medication; this could not, however, explain the differences in blood pressure observed. While most religious activity was associated with lower blood pressure, those who frequently watched religious TV or listened to religious radio actually had higher blood pressures. Conclusions: Religiously active older adults tend to have lower blood pressures than those who are less active. This applies to attendance at religious services and private religious activities, but not to religious media. Physiological mechanisms are discussed.
Experimental Study of a Ceramic Microsparging Aeration System in a Pilot‐Scale Animal Cell Culture

The oxygen supply of cell cultures with the aid of free gas bubbles is an efficient process strategy in pharmaceutical production. If the cell‐damaging impact of gas bubbles is reduced, direct aeration becomes a practical solution with scale‐up potential and comparatively high oxygen transfer rates. In this paper a microsparging aeration system made of porous ceramic was compared with bubble‐free membrane aeration. The sparging system was used for the long‐term cultivation of mammalian cells in 2‐to 100‐L scale bioreactors and produced bubble sizes of 100–500 μm in diameter. Using a scale of 2.5 and 30 L, a cell density of 2.6 × 106 cells/mL was attained. When a 100‐L scale was used, a density of 1.1 × 106 cells/mL was achieved, whereas a comparable membrane‐aerated system showed a cell density of 2.2 × 106 cells/mL. At relatively low agitation rates of less than 70 rpm in the sparged bioreactors, a homogeneous and constant oxygen concentration was kept in the medium. As a result of the different foam‐forming tendency caused by the lower gas flow of the ceramic sparger compared to that of the standard aeration systems, we were able to develop an appropriate process control strategy. Furthermore, oxygen transfer measurements for the common stainless steel sparger and the ceramic sparger showed a 3‐fold higher oxygen transfer coefficient for the ceramic sparger.
Optimal server assignment in multi-server parallel queueing systems with random connectivities and random service failures

The problem of assignment of K identical servers to a set of N symmetric parallel queues is investigated in this paper. The parallel queueing system is considered to be time slotted and the connectivity of each queue to each server is varying randomly over time and following Bernoulli distribution with a given parameter. Each server is capable of serving at most one packet per time slot (if it is connected and assigned to a queue). At any time slot, each server can serve at most one queue and each queue can be served by at most one server. We assume that the service of a scheduled packet by a connected server fails randomly with a certain probability. The packet arrival processes to the queues are assumed to be i.i. d. and follow Bernoulli distribution with a fixed parameter. For such a symmetric system, i.e., with the same arrival, connectivity and service failure parameters for all the queues, we show that Maximum Weighted Matching (MWM) server assignment policy is delay optimal. More specifically, using stochastic ordering and dynamic coupling techniques we prove that MWM minimizes, in stochastic ordering sense, a broad range of stochastic cost functions of the queue lengths including total queue occupancy (or equivalently average queueing delay).
A Comparison of Moisture Scalars and Water Budget Methods to Assess Vegetation-Site Relationships

Quantification of vegetation-site relationships is often required in biogeographic research. Methods linking species to particular sites typically assess evaporative demand and soil moisture availability at the site, though methods differ in how these factors are assessed. This study compares three approaches—a water-budget approach, and field-based and map-based moisture scalars—in their ability to predict the occurrence of a single species, American beech (Fagus grandifolia), observed in 102, 0.04 ha plots in SE Ohio. Actual evapotranspiration and deficit provided results superior to field-based and map-based scalars. Map-based techniques are potentially limited at fine spatial scales, due to the large discrepancy between observed topographic variables, and those modeled with 7.5-minute elevation grids. The study concludes that a water budget approach is applicable to a wide range of studies exploring vegetation-site linkages. It has advantages of being objective in its computation, and applicable at a wide range of spatial scales. Perhaps most importantly with regard to global change research is the dynamic nature of the method: a site's classification will change concurrently with changes in climate.
Sex-related similarities and differences in the neural correlates of beauty

The capacity to appreciate beauty is one of our species' most remarkable traits. Although knowledge about its neural correlates is growing, little is known about any gender-related differences. We have explored possible differences between men and women's neural correlates of aesthetic preference. We have used magnetoencephalography to record the brain activity of 10 male and 10 female participants while they decided whether or not they considered examples of artistic and natural visual stimuli to be beautiful. Our results reveal significantly different activity between the sexes in parietal regions when participants judged the stimuli as beautiful. Activity in this region was bilateral in women, whereas it was lateralized to the right hemisphere in men. It is known that the dorsal visual processing stream, which encompasses the superior parietal areas, has been significantly modified throughout human evolution. We posit that the observed gender-related differences are the result of evolutionary processes that occurred after the splitting of the human and chimpanzee lineages. In view of previous results on gender differences with respect to the neural correlates of coordinate and categorical spatial strategies, we infer that the different strategies used by men and women in assessing aesthetic preference may reflect differences in the strategies associated with the division of labor between our male and female hunter-gatherer hominin ancestors.
Dynamic DNA methylation reprogramming: Active demethylation and immediate remethylation in the male pronucleus of bovine zygotes

DNA methylation reprogramming (DMR) is believed to be a key process by which mammalian zygotes gain nuclear totipotency through erasing epigenetic modifications acquired during gametogenesis. Nonetheless, DMR patterns do not seem to be conserved among mammals. To identify uniform rules underlying mammalian DMRs, we explored DMRs of diverse mammalian zygotes. Of the zygotes studied, of particular interest was the bovine zygote; the paternal DNA methylation first decreased and was then rapidly restored almost to the maternal methylation level even before the two‐cell stage. The 5‐azadeoxycytidine treatment led to complete demethylation of the male pronucleus. The unusually dramatic changes in DNA methylation levels indicate that the bovine male pronucleus undergoes active demethylation, which is followed by de novo methylation. Our results show that, in bovine, the compound processes of active DNA demethylation and de novo DNA methylation, along with de novo H3‐K9 trimethylation also, take place altogether within this very narrow window of pronucleus development. Developmental Dynamics 236:2523–2533, 2007. © 2007 Wiley‐Liss, Inc.
Design of Broadband, Single Layer Dual-Band Large Reflectarray Using Multi Open Loop Elements

A novel method is introduced to design a single layer, dual-band large printed reflectarray with open loop elements of variable size for both bands. The reflectarray is designed for two frequency bands: 11.4-12.8 GHz for receive and 13.7-14.5 GHz for transmit. Different classes of open cross loop elements were used in the design of the receive band elements. Noting the larger relative bandwidth at the lower band as compared to the upper band, the dimensions of these cross loops are adjusted, using an optimization technique to achieve required phase distribution at the center frequency and minimize frequency dispersion at extreme frequencies of the lower band. Double square open loop elements with variable loop length were used for the transmit band elements. The reflectarray consists of 3 × 3 panels of 40 cm × 40 cm, that are arranged side by side to construct the large 120 cm × 120 cm reflectarray. The flat configuration and modular nature of this reflectarray gives it an advantage from the installation point of view as compared to conventional dish antennas.
Risk of Death Among Children Reported for Nonfatal Maltreatment

This article presents analyses of longitudinal data to explore whether low-income children who survived a first incident of reported maltreatment were at higher risk of later childhood death compared to a matched comparison group of low-income children without reports of maltreatment (n = 7,433). Compared to the comparison group, children in the maltreatment group had about twice the risk of death before age 18 (0.51% vs. 0.27%). Among children with mal-treatment reports, median time from the first report to subsequent death was 9 months. The majority of deaths among children who were reported for maltreatment could be categorized as preventable (accidents or recurrent maltreatment) as compared to resulting from severe health conditions.
The Feasibility, Safety, and Efficacy of Using a Wireless Pedometer to Improve the Activity Level in a Cohort of Nurses

Purpose: This study had two aims: (1) to test the feasibility, safety, and efficacy of using a wireless pedometer in a cohort of nurses; and (2) to understand if wireless pedometer use increased number of steps walked, number of flights of stairs climbed, daily activity level, and improved personal perception of health. Design: This study used a nonexperimental exploratory design to test the feasibility and efficacy of using a wireless pedometer in a cohort of nurses. Pre- and posttest measures captured the number of steps walked, flights of stairs climbed, activity level, and perception of health. Results: Sample characteristics: 27 females, 3 males; 90% non-Hispanic Caucasian, 3% Hispanic; 47% between the ages of 55 and 65 years. Eighty percent of the participants reported that they were caregivers of other people. There was a significant increase from baseline to the end of the study in the following measures: self-perception of steps walked (p < .001), flights of stairs climbed (p < .005), self-perception of daily activity (p < .001), and although there was an improvement in self-perception of health, the change was not significant. Conclusions: The wireless pedometer was a feasible, safe, and efficacious device to use. This study may have implications for interventions aimed at improving caregiver health.
Let’s Talk it Out: The Effects of Calibration Meetings on Performance Ratings

ABSTRACT Despite their use in practice, calibration meetings of performance appraisal ratings have received little attention in the academic literature to date. The current paper addresses this gap by formally defining calibration meetings and by investigating the nature and impact of calibration meetings on performance ratings across two field studies. Results indicated that calibration meetings do occur in organizations. The nature and cadence of calibration meetings varied considerably, but managers generally perceived calibrations as attempts to improve rating quality. Calibration meetings were also associated with increases in perceived frame-of-reference, perceived accountability, and perceived total information to base ratings upon. Further, results showed that post-calibration ratings correlated more with other measures assessing the job performance domain than pre-calibration ratings.
Complete remissions observed in acute myeloid leukemia following prolonged exposure to lintuzumab: a phase 1 trial

A multi-institutional, phase 1 dose-escalation trial of lintuzumab (humanized anti-CD33 antibody; SGN-33, HuM195) was performed in patients with CD33-positive myeloid malignancies. In this study, higher doses than previously tested and prolonged duration of treatment for responding patients were evaluated. Over the dose range of 1.5–8 mg/kg/week, lintuzumab was well tolerated, and a maximum tolerated dose was not defined. The most common adverse event was transient chills with the initial lintuzumab infusion (39%). Responses were observed in 7 of 17 patients with acute myeloid leukemia: morphologic complete remission (n = 4), partial remission (n = 2), and morphologic leukemia-free state (n = 1). Of 14 patients with myelodysplastic syndrome or myeloproliferative diseases, 1 patient had major hematologic improvement and 9 patients had stable disease. In contrast to aggressive conventional chemotherapy, lintuzumab was administered in an ambulatory clinic setting with acceptable toxicity.
Evaluation of dentinal tubule occlusion and depth of penetration of nano-hydroxyapatite derived from chicken eggshell powder with and without addition of sodium fluoride: An in vitro study

Aim: This in vitro study evaluated the degree of dentinal tubule occlusion and depth of penetration of nano-hydroxyapatite (nHAp) derived from chicken eggshell powder with and without the addition of 2% sodium fluoride (NaF) using scanning electron microscope (SEM) and confocal laser scanning microscope (CLSM). Materials and Methods: nHAp was synthesized and characterized using X-ray diffraction and SEM-energy dispersive spectroscopy. Dentin discs were obtained from extracted teeth, pretreated with 17% ethylenediaminetetraacetic acid for 5 min and were divided into four groups based on the experimental agents as follows: Group 1: Untreated (control), Group 2: 2% NaF, Group 3: nHAp, Group 4: Combination of nHAp and 2% NaF. The treatment protocol was carried out for 7 days, after which the specimens were viewed under SEM and CLSM. Statistical Analysis Used: One-way ANOVA and Tukey′s post hoc multiple comparison tests (P < 0.05). Results: All the experimental agents occluded the dentinal tubules, but to varying degrees and depths. Specimens treated with the combination of nHAp and 2% NaF showed complete dentinal tubular occlusion and significantly greater depth of penetration than those treated with nHAp and 2% NaF alone. Conclusion: The combination of nHAp and 2% NaF was the most effective in occluding dentinal tubules.
MID-INFRARED SELECTION OF ACTIVE GALACTIC NUCLEI WITH THE WIDE-FIELD INFRARED SURVEY EXPLORER. I. CHARACTERIZING WISE-SELECTED ACTIVE GALACTIC NUCLEI IN COSMOS

The Wide-field Infrared Survey Explorer (WISE) is an extremely capable and efficient black hole finder. We present a simple mid-infrared color criterion, W1 − W2 ⩾ 0.8 (i.e., [3.4]−[4.6] ⩾0.8, Vega), which identifies 61.9 ± 5.4 active galactic nucleus (AGN) candidates per deg2 to a depth of W2 ∼ 15.0. This implies a much larger census of luminous AGNs than found by typical wide-area surveys, attributable to the fact that mid-infrared selection identifies both unobscured (type 1) and obscured (type 2) AGNs. Optical and soft X-ray surveys alone are highly biased toward only unobscured AGNs, while this simple WISE selection likely identifies even heavily obscured, Compton-thick AGNs. Using deep, public data in the COSMOS field, we explore the properties of WISE-selected AGN candidates. At the mid-infrared depth considered, 160 μJy at 4.6 μm, this simple criterion identifies 78% of Spitzer mid-infrared AGN candidates according to the criteria of Stern et al. and the reliability is 95%. We explore the demographics, multiwavelength properties and redshift distribution of WISE-selected AGN candidates in the COSMOS field.