Miracle-dz/UniFAR-FTUs huggingface dataset:
Calmodulin and Calmodulin-dependent Kinase IIα Regulate Osteoblast Differentiation by Controlling c-fos Expression*

Ca2+/calmodulin-dependent protein kinase IIα (α-CaMKII) was once thought to be exclusively expressed in neuronal tissue, but it is becoming increasingly evident that CaMKII is also expressed in various extraneural cells. CaMKII plays a critical role in regulating various signaling pathways leading to modulation of several aspects of cellular functions, including proliferation, differentiation, cytoskeletal structure, and gene expression. The purpose of this study was to examine the expression of CaMKII in osteoblast-like cells (MC4) and to elucidate its role in osteoblast differentiation. We demonstrated that CaMKII, specifically the α isoform, is expressed in osteoblasts both in vitro and in vivo. Inhibition of CaMKII by the calmodulin antagonist trifluoperazine or the CaMKII antagonist KN93 reduces alkaline phosphatase activity and mineralization, as well as causes 85 and 56% decreases in alkaline phosphatase and osteocalcin gene expression, respectively. CaM and CaMKII antagonists, using the newborn mouse calvaria in vivo model, cause a 50% decrease in osteoblast number (N.Ob-BS) and a 32% decrease in mineralization (BV/TV). Pharmacologic and genetic inhibition of α-CaMKII by using trifluoperazine, KN93, and α-CaMKII small interfering RNA decreases the phosphorylation of ERK and of cAMP-response element-binding protein, leading to a significant decrease in the transactivation of serum response element and cAMP-response element. Inhibition of α-CaMKII decreases the expression of c-fos, AP-1 transactivation, and AP-1 DNA binding activity. Our findings demonstrated that α-CaMKII is expressed in osteoblasts and is involved in c-fos expression via regulation of serum response element and cAMP-response element. Inhibition of α-CaMKII results in a decrease in c-fos expression and AP-1 activation, leading to inhibition of osteoblast differentiation.
Transaction Repair for Multi-Version Concurrency Control

The optimistic variants of Multi-Version Concurrency Control (MVCC) avoid blocking concurrent transactions at the cost of having a validation phase. Upon failure in the validation phase, the transaction is usually aborted and restarted from scratch. The "abort and restart" approach becomes a performance bottleneck for use cases with high contention objects or long running transactions. In addition, restarting from scratch creates a negative feedback loop in the system, because the system incurs additional overhead that may create even more conflicts. In this paper, we propose a novel approach for conflict resolution in MVCC for in-memory databases. This low overhead approach summarizes the transaction programs in the form of a dependency graph. The dependency graph also contains the constructs used in the validation phase of the MVCC algorithm. Then, when encountering conflicts among transactions, our mechanism quickly detects the conflict locations in the program and partially re-executes the conflicting transactions. This approach maximizes the reuse of the computations done in the initial execution round, and increases the transaction processing throughput.
Functional MRI mapping of occipital and frontal cortical activity during voluntary and imagined saccades

We investigated the activation of frontal and occipital cortical areas in 14 normal volunteers during voluntary saccades in light or dark and during imagined saccades using functional magnetic resonance imaging (FMRI) with electro-oculogram monitoring. Voluntary saccades in light or dark and imagined saccades led to a significant activation (p < 0.005) of the precentral and posterior medial frontal gyrus (frontal eye field). The medial part of the superior frontal gyrus (supplementary eye field) also showed significant activity during voluntary saccades in all subjects, but only in four subjects during imagined saccades. In addition to frontal activity we found an activated primary visual cortex during voluntary saccades, both in light and in dark. In contrast to executed saccades, imagined eye movements revealed no occipital response under either condition. Our FMRI study supports the concept of frontal eye fields during voluntary saccades and demonstrates that occipital areas are associated with the generation of voluntary eye movements. However, the primary visual cortex is not active when eye movement is only imagined.
Can real time location system technology (RTLS) provide useful estimates of time use by nursing personnel?

Accurate, precise, unbiased, reliable, and cost-effective estimates of nursing time use are needed to insure safe staffing levels. Direct observation of nurses is costly, and conventional surrogate measures have limitations. To test the potential of electronic capture of time and motion through real time location systems (RTLS), a pilot study was conducted to assess efficacy (method agreement) of RTLS time use; inter-rater reliability of RTLS time-use estimates; and associated costs. Method agreement was high (mean absolute difference = 28 seconds); inter-rater reliability was high (ICC = 0.81-0.95; mean absolute difference = 2 seconds); and costs for obtaining RTLS time-use estimates on a single nursing unit exceeded $25,000. Continued experimentation with RTLS to obtain time-use estimates for nursing staff is warranted.
Control of a high torque density seven-phase induction motor with field-weakening capability

In this paper, a rotor-flux-oriented control scheme for seven-phase induction motor drives is presented. At low speed the proposed control scheme is able to increase the motor torque by adding a third harmonic component to the air-gap magnetic field. Above the base speed the control system reduces the motor flux in such a way to ensure the maximum torque capability. The validity of the proposed control scheme is confirmed by experimental tests.
A Dynamic Explanation of the Willingness to Pay and Willingness to Accept Disparity

Evidence from laboratory experiments suggests that important disparities exist between willingness to pay (WTP) and compensation demanded for the same good. This study advances, and experimentally tests, a new explanation of the WTP/WTA disparity--a dynamic theory based on the presence of commitment costs. We find that the commitment cost theory combined with a simple behavioral anomaly is able to lend insights into the causes and severity of the WTA/WTP disparity. Further, we find that market experience attenuates the behavioral anomaly, consistent with the notion that no value disparity exists for agents with sufficient market experience.
Design of an ultra-flattened negative dispersion elliptical spiral photonic crystal fiber with high nonlinearity and high birefringence

Novel elliptical spiral photonic crystal fiber(PCF) having ultra-flattened negative dispersion, high nonlinearity and high birefringence is proposed. The finite element method is used to optimize the guiding properties. This design provides negative dispersion that is ultra-flattened within range of wavelength from 1385 nm to 1990 nm with deviation of ± 1.5 ps/nm/km. Dispersion value of −93.577 ps/nm/km at 1550 nm wavelength is achieved. The numerical results also indicate the birefringence up to order of 10−2 and nonlinear coefficient of (678.264, 763.485) W−1km−1 at 1550 nm wavelength for fundamental X and Y polarized modes.
Implant-supported removable partial dentures in the mandible

Conventional removable partial dentures (RPD) in a free-ending situation in the lower jaw (i.e. only front teeth left) have a poor reputation. Several problems like discomfort and functional problems are frequently encountered, resulting in dissatisfied patients and desperate dentists. By supporting the RPD by implants, good results were reported by other researchers as we started our clinical trial, be it based on weak scientific evidence. In our randomized cross-over clinical trial several aspects of implant-supported removable partial dentures in the mandible were investigated. Clinical –, radiographical – as well as functional aspects and patient-based outcome measures were obtained and related to different implant positions within each patient: more to the front or further to the back of the lower jaw. This concept was unique and innovative. In addition cost-effectiveness and the radiographical interpretation of bone volume were studied. In general it is concluded that patients are well served with an implant-supported RPD, regardless of implant-position. Implant-support resulted in a significant improved chewing ability, oral health related quality of life and patient satisfaction with stable clinical and technical conditions. Based on the preference of patients, the implants should be placed more to the back, but from a clinical point of view it is wise to place the implants directly behind the last remaining natural teeth. The cost-effectiveness is determined and dependent on the willingness of the payer to invest. Panoramic radiographs suffice in most of the cases for the evaluation of implant placement in the lateral parts of the lower jaw.
Acquired Opercular Epilepsy With Oromotor Dysfunction: Magnetoencephalographic Analysis and Efficacy of Corticosteroid Therapy

The authors describe herein the magnetoencephalographic findings and long-term outcome of a girl with acquired opercular epilepsy with oromotor dysfunction. She presented with brief episodes of unconsciousness, tremulous movements of the upper limbs, and negative myoclonus, in addition to convulsive seizures. She also had prolonged episodes of dysarthria and oral motor dysfunction, a gradual decrease in speech output, impairment of finger movements, and deterioration in cognitive performance over several years. Her electroencephalography (EEG) recordings showed notable continuous sharp or sharp-slow discharges during sleep. Brain magnetic resonance images revealed no structural anomalies. Magnetoencephalographic analysis showed broadly distributed epileptic foci around the sylvian fissure, including a secondary source, explaining the specific prolonged neurological dysfunction. Antiepileptic drugs could control her seizures; however, they did not improve the other neurological symptoms or epileptiform discharge on EEG. Administration of low-dose prednisolone over a long period was effective for improving the neurological impairments of this patient.
Phase Competitions behind the Giant Magnetic Entropy Variation: Gd5Si2Ge2 and Tb5Si2Ge2 Case Studies

Magnetic materials with strong spin-lattice coupling are a powerful set of candidates for multifunctional applications because of their multiferroic, magnetocaloric (MCE), magnetostrictive and magnetoresistive effects. In these materials there is a strong competition between two states (where a state comprises an atomic and an associated magnetic structure) that leads to the occurrence of phase transitions under subtle variations of external parameters, such as temperature, magnetic field and hydrostatic pressure. In this review a general method combining detailed magnetic measurements/analysis and first principles calculations with the purpose of estimating the phase transition temperature is presented with the help of two examples (Gd5Si2Ge2 and Tb5Si2Ge2). It is demonstrated that such method is an important tool for a deeper understanding of the (de)coupled nature of each phase transition in the materials belonging to the R5(Si,Ge)4 family and most possibly can be applied to other systems. The exotic Griffiths-like phase in the framework of the R5(SixGe1-x)4 compounds is reviewed and its generalization as a requisite for strong phase competitions systems that present large magneto-responsive properties is proposed.
Energy Optimization using Particle Swarm Optimization based on Clustering for Wireless Sensor Network

Wireless Sensor Network (WSN) is a self-organizing network which formed with huge sensors which are located in an application specific environment to monitor the physical pheromone like temperature, fire, and pressure. Mostly sensors are equipped with battery power through which they can perform sufficient operations and communication among neighboring nodes. Researchers for WSNs face challenge that arises from limited energy. Maximizing the lifetime of the WSN, energy conservation measures are essential for improving the performance of WSNs. Particle Swarm Optimization (PSO) is used to form clustering and select cluster head with respect to minimizing the power consumption in WSN. This paper discusses about energy optimization using PSO based on clustering algorithms for WSN, which aims to extend network lifetime.
The role of recollection and familiarity in the functional differentiation of the medial temporal lobes

The components of the medial temporal lobes (MTL) receive different kinds of input. The perirhinal cortex receives primarily object/item information, the parahippocampal cortex receives contextual information, and the hippocampus receives high‐level inputs that include object/item, context, and other information. Critically, the perirhinal and parahippocampal cortices have similar cytoarchitectonics, which differ considerably from that of the hippocampus and suggest that these cortices process their inputs differently from the way that the hippocampus processes its inputs. Much evidence indicates that the hippocampus is designed to rapidly bind together pattern‐separated representations that support recall/recollection i well. In contrast, the newer MTL cortices rapidly create poorly pattern‐separated memories that support familiarity well, but recall/recollection very poorly. For over a decade, there has been disagreement about whether recall/recollection is primarily mediated by the hippocampus and familiarity by the evolutionarily newer MTL cortices or whether the MTL mediates these kinds of memory in an integrated, homogeneous fashion. Common misconceptions about familiarity, recollection, item, and associative memory are discussed as are methodological problems with MTL lesion and functional imaging research. The possible confound of familiarity with weaker memory and recollection with stronger memory is discussed and the implications of the Montaldi et al. ( 2006 ) functional Magnetic Resonance Imaging (fMRI) study, which matched memory strength between strong familiarity and recollection, finding that only recollection activated the hippocampus, are discussed. A suggestion is made about how the long‐running conflict of findings in the human hippocampal lesion literature may be resolved. © 2010 Wiley‐Liss, Inc.
Electroporation: a method for transferring genes into the gametes of zebrafish (Brachydanio rerio), channel catfish (Ictalurus punctatus), and common carp (Cyprinus carpio).

Recombinant plasmids containing the Rous sarcoma virus long-terminal repeat (RSVLTR) promoter linked to either rainbow trout (Oncorhyncus mykiss) growth hormone 1 (rtGH1) or growth hormone 2 (rtGH2) cDNA were linearized and introduced into the fertilized eggs of zebrafish (Brachydanio rerio), channel catfish (Ictalurus punctatus), and common carp (Cyprinus carpio) by both electroporation and microinjection. The latter two species had these rainbow trout constructs (RSVLTR-rtGH1cDNA or RSVLTR-rtGH2) electroporated into both gametes (i.e., sperm and unfertilized eggs) prior to fertilization, into eggs shortly after fertilization, and at the first cell division stage. Survival was determined just after hatching and again between 3 and 5 months after hatching. Polymerase chain reactions and Southern blot analyses were used to detect those individuals carrying the introduced foreign genes 3 to 5 months after hatching, respectively. Individuals analyzed by both methods yielded identical results in a double-blind study. The electroporation results were compared with groups that were microinjected. Although survival was similar, electroporation tended to produce a greater number of transgenic individuals than the microinjection procedure, and many more eggs could be treated per unit time by electroporation than microinjection. Survival was better for common carp when electroporation was performed shortly after fertilization, whereas channel catfish fared better at the first cell division stage. Electroporation prior to and shortly after fertilization, and at the first cell stage appeared to generate a large fraction of transgenic fish. We cautiously conclude that electroporation is an efficient method for introducing foreign DNA into fish gametes and embryos and may be an ideal method for treating large numbers of gametes in a modest period.
Proposta de um Modelo de Avaliação de Jogos Educacionais

Este artigo apresenta e propoe um modelo para a avaliacao de jogos educacionais baseado no modelo de avaliacao de programas de treinamento de Kirkpatrick, nas estrategias motivacionais do modelo ARCS de Keller, na area de experiencia do usuario e na taxonomia de objetivos educacionais de Bloom. A estrutura do modelo e um questionario para a coleta de dados com base da percepcao dos alunos sao apresentados. Espera-se que este modelo possa trazer contribuicoes para a qualidade de jogos educacionais e a orientar professores na selecao e uso deste tipo de material educacional.
Preinduction Cervical Softening with Endocervical Pge2 Gel: A multi‐center trial

In a prospective, randomized trial, a single dose of PGE2 gel, 0.5 mg (2.5 ml), was given to 416 low Bishop Score patients 12 h prior to indicated oxytocin induction and compared with 404 non‐gel controls. Successful initial induction was achieved in 83% of the treated and 58% of the non‐treated subjects. In addition the induction—delivery interval was shortened (median times 9.0 h vs. 11.3 h) and fewer cesarean sections were performed (16% vs. 21%) in the PGE2 gel series. The endocervical administration of PGE2 was well tolerated and, provided care is taken to avoid excess extra‐amniotic placement, systemic PGE2 effects are minimal.
Identifying the Discount Factor in Dynamic Discrete Choice Models

Empirical research often cites observed choice responses to variation that shifts expected discounted future utilities, but not current utilities, as an intuitive source of information on time preferences. We study the identification of dynamic discrete choice models under such economically motivated exclusion restrictions on primitive utilities. We show that each exclusion restriction leads to an easily interpretable moment condition with the discount factor as the only unknown parameter. The identified set of discount factors that solves this condition is finite, but not necessarily a singleton. Consequently, in contrast to common intuition, an exclusion restriction does not in general give point identification. Finally, we show that exclusion restrictions have nontrivial empirical content: The implied moment conditions impose restrictions on choices that are absent from the unconstrained model.
Types of reactions to malignant disease in view of V.E. Frankl philosophy.

PURPOSE The purpose of this work was to find out whether there is interdependence between the patients- assessments of biological, psychological, psychosocial and spiritual levels. METHODS 590 subjects, both ill and healthy, were examined by appropriate means and asked to consider their level of fear, depression (Hospital Anxiety and Depression Scale - Modification), aggression, quality of life (EORTC QLQ-C30 questionnaire), and the purpose and meaning of life (The "PURPOSE in Life Test" - PIL questionnaire). RESULTS Three groups of patients were established with the help of statistical procedures. The first group encompassed the healthy subjects, whereas the second and third included those that were ill. Although the subjects estimated their level of physical fitness and general quality of life similarly, there were some essential differences in their disease-associated reactions (i.e. the groups adjusted differently - the second group poorly and the third well). The majority of people suffering from cancer were well adapted to the early stages of the disease. As cancer progressed the percentage of those that adjusted poorly rose. However, even in the terminal stage some of the patients, about 1/3, still belonged to the group of those that were quite well adjusted. Established meaning of life, system of values, and personal religion were factors that helped to adapt. CONCLUSIONS There was no connection between the patients' assessments of their biological level and other (psychological, psychosocial, spiritual) levels. We can distinguish groups of patients that judge their physical condition similarly and still vary in the assessment of their emotional state or meaning of life.
A Dynamic Edge Exchangeable Model for Sparse Temporal Networks

We propose a dynamic edge exchangeable network model that can capture sparse connections observed in real temporal networks, in contrast to existing models which are dense. The model achieved superior link prediction accuracy on multiple data sets when compared to a dynamic variant of the blockmodel, and is able to extract interpretable time-varying community structures from the data. In addition to sparsity, the model accounts for the effect of social influence on vertices' future behaviours. Compared to the dynamic blockmodels, our model has a smaller latent space. The compact latent space requires a smaller number of parameters to be estimated in variational inference and results in a computationally friendly inference algorithm.
Diversity and Abundance of Zoonotic Pathogens and Indicators in Manures of Feedlot Cattle in Australia

ABSTRACT The occurrence of 10 pathogens and three fecal indicators was assessed by quantitative PCR in manures of Australian feedlot cattle. Most samples tested positive for one or more pathogens. For the dominant pathogens Campylobacter jejuni, Listeria monocytogenes, Giardia spp. , Cryptosporidium spp. , and eaeA-positive Escherichia coli, 102 to 107 genome copies g−1 (dry weight) manure were recovered.
Measuring end user satisfaction in enterprise resource planning in India

End user satisfaction in enterprise resource planning ERP among the employees in India has been analysed using EUCS instrument. This study is unique in including 'expectations' and 'dependable' to measure satisfaction in a modified EUCS scale. EUCS had been used only in a few of the studies in ERP and the existing literature on user satisfaction also had emphasised the need for retesting of the instrument in many countries and cultures. ERP market in India is expected to grow at a CAGR of 22.2% over the period 2011-2015 TechNavio and India is a key player in the IT market. Its IT end users are culturally different from other countries. Hence, there is need for this study and for re-testing the EUCS instrument among the end users of ERP in India. The study also attempted to find the differences in satisfaction among the employees having different work experiences and demographic characteristics.