Miracle-dz/UniFAR-FTUs huggingface dataset:
Childhood Maltreatment Among Hispanic Women in the United States

Prevalence rates of childhood maltreatment among Hispanic women in the United States are presented separately for nativity status and ethnic origin subgroups, and the associations between different types of maltreatment and the development of anxiety and depressive disorders are examined. Analyses used self-report data from 1,427 Hispanic women who participated in the National Latino and Asian American Survey. Foreign-born Hispanic women compared to U.S.-born Hispanic women reported significantly lower rates of sexual assault and witnessing interpersonal violence, and a significantly higher rate of being beaten. Ethnic subgroups reported similar rates of maltreatment, with the exception of rape. Bivariate analyses were remarkably consistent in that regardless of nativity status or ethnic subgroup, each type of maltreatment experience increased the risk of psychiatric disorder. In multivariate models controlling for all types of victimization and proxies of acculturation, having been beaten and witnessing interpersonal violence remained significant predictors of both disorders, but sexual abuse increased risk of anxiety only. A significant interaction effect of family cultural conflict and witnessing violence on anxiety provided very limited support for the hypothesis that acculturation moderates the influence of maltreatment on mental health outcomes. Implications for culturally relevant prevention and intervention approaches are presented.
Function and specificity of synthetic Hox transcription factors in vivo

Homeotic (Hox) genes encode transcription factors that confer segmental identity along the anteroposterior axis of the embryo. However the molecular mechanisms underlying Hox-mediated transcription and the differential requirements for specificity in the regulation of the vast number of Hox-target genes remain ill-defined. Here we show that synthetic Sex combs reduced (Scr) genes that encode the Scr C terminus containing the homedomain (HD) and YPWM motif (Scr-HD) are functional in vivo. Synthetic Scr-HD peptides can induce ectopic salivary glands in the embryo and homeotic transformations in the adult fly, act as transcriptional activators and repressors during development, and participate in protein-protein interactions. Their transformation capacity was found to be enhanced over their full-length counterpart and mutations known to transform the full-length protein into constitutively active or inactive variants behaved accordingly in the synthetic peptides. Our results show that synthetic Scr-HD genes are sufficient for homeotic function in Drosophila and suggest that the N terminus of Scr has a role in transcriptional potency, rather than specificity. We also demonstrate that synthetic peptides behave largely in a predictable way, by exhibiting Scr-specific phenotypes throughout development, which makes them an important tool for synthetic biology.
Retrospective Analysis of Women with Only Mastalgia.

OBJECTIVE Mastalgia is the most common symptom in women, who has gone under breast imaging. 70% of women face with mastalgia at least once in their lifetime. In our study, we aimed to investigate the examinations and the results of the females referred to our outpatient clinics with mastalgia and to determine the frequency of malignancy. MATERIALS AND METHODS Files of all women patients referred to General Surgery Outpatient Clinics between 01.06. 2014-31.05. 2015 has been investigated retrospectively. Cases only with breast pain complaint (n=789) out of 2798 women has been included in the study. Women with lump in breast, nipple discharge, redness, breast retraction and pregnant and lactating women were excluded. Breast examination findings, ultrasonography (USG), mammography results, whether biopsies are done or not and diagnoses have been investigated retrospectively. RESULTS Mean age was 42.97±12.36 (16-74) years. 59.7% (n=471) of the women had bilateral mastalgia and 91.1% (n=719) of the breast examinations were found to be normal. USG was required from 664 (84.2%) women and mammography was required from 448 (56.8%) women. Considering diagnoses; fibrocystic changes in 32.3% (n=201), ductal ectasia in 8.8% (n=55), fibroadenomas in 6.1% (n=38), reactive lymphoid hyperplasia in 1.1% (n=7) was observed. Only 1 (0.2%) woman was diagnosed with invasive ductal carcinoma. CONCLUSION According to researches, 0.5% of the women with mastalgia were diagnosed with breast cancer. In our study this rate was found as 0.2%. Women with only mastalgia without any abnormality in physical examination should be informed about dealing with pain.
Risks of suicide and poisoning among elderly patients prescribed selective serotonin reuptake inhibitors: a retrospective cohort study.

BACKGROUND Treatment with selective serotonin reuptake inhibitors (SSRIs) has been associated with increased suicide risk. Risks of suicide death and of poisoning were compared during periods of SSRI treatment versus periods without any antidepressant treatment among elderly patients. METHOD In this retrospective cohort study, records from the Quebec Health Care Fund and Vital Statistics databases were obtained for patients 65 years and older who had filled a prescription for an SSRI between January 1998 and December 2004. Patients were followed from the filling date of the first SSRI prescription during the study period until death, the end of the first period extending for at least 365 days with no antidepressant supply, or December 31, 2004, whichever occurred first. RESULTS The cohort included 128,229 patients (mean age = 75.4 years), 70% of whom were women. Numbers of suicide deaths (crude rate/100,000 patient-years) were 37 (23) during SSRI use, 16 (51) during other antidepressant use, 5 (54) during use of both an SSRI and another anti-depressant, and 29 (29) during no antidepressant use. The adjusted risk of suicide death (Cox regression model with time-dependent exposure) was not higher during SSRI use versus nonuse (hazard ratio [95% CI]): any SSRI = 0.64 (0.38 to 1.07), paroxetine = 0.71 (0.37 to 1.35), citalopram = 1.16 (0.59 to 2.25), and sertraline = 0.38 (0.16 to 0.93). The adjusted hazard ratio (95% CI) of poisoning was higher during SSRI use versus nonuse (1.16 [1.07 to 1.25]) and varied between SSRI agents from 0.93 (0.74 to 1.16) for fluoxetine to 1.45 (1.23 to 1.71) for fluvoxamine. CONCLUSION Among elderly patients dispensed SSRIs, the risk of suicide death was not higher during periods of SSRI use compared to when antidepressants were not being used.
Characteristics and impacts of ICT investments: perceptions among managers

Purpose – The purpose of this paper is to study the characteristics and impacts of information‐communication technology (ICT) investments as perceived by ICT managers.Design/methodology/approach – The paper starts with an overview and a conceptualisation. The empirical part is based on a national RIS 2005 representative telephone survey (n=727) of companies in Slovenia. With respect to ICT developments the Republic of Slovenia, situated between Italy, Austria, Hungary and Croatia, is a typical (median) country of the European Union.Findings – The size of ICT investments strongly determined the perception of ICT investments, but it had surprisingly little impact on its structure (i.e. hardware, software, education …). Satisfaction with ICT investments was relatively low, particular in small companies. One reason for this was the suboptimal implementation, particularly the lack of accompanying measures (e.g. education, organisational changes). The ICT investments brought considerable changes for the interna.
Public health monitoring of developmental disabilities with a focus on the autism spectrum disorders

Developmental disabilities (DDs) are conditions characterized by physical, cognitive, psychological, sensory, adaptive, and/or communication impairments manifested during development. Approximately 17% of individuals in the United States 18 years and younger have a DD, and for most children the cause of their condition is unknown. Of particular interest are the autism spectrum disorders (ASDs), characterized by unusual social, communication, and behavioral development. Previously autism was thought to be a rare condition, but the number of children receiving services for an ASD has increased dramatically in the last decade. Concerns about increases in DDs, particularly ASDs, their causes, and the high costs of intervention have highlighted the need for systematic public health monitoring. Service provider data, such as annual reporting of special education services or of state DD programs, do not provide a complete estimate of the rates for DDs, including ASDs. Unlike genetic metabolic disorders or congenital hearing loss (HL) for which newborn screening programs can provide accurate prevalence rates, there are currently no genetic or biologic markers for the ASDs to enable consistent and early identification of affected children. Centers for Disease Control and Prevention's (CDC) Metropolitan Atlanta Developmental Disabilities Surveillance Program (MADDSP) is a model for population monitoring of ASDs/DDs that has been implemented in other states. This article discusses the role of ASD/DD tracking in public health, as well as the challenges of ASD/DD tracking, including case definition and identification, associated conditions, linkages, and data access. © 2004 Wiley‐Liss, Inc.
The prevalence of bother, acceptance, and need for help in men with erectile dysfunction.

INTRODUCTION Apart from knowledge on the prevalence of erectile dysfunction (ED), for clinical reasons it is important to obtain information on concern or bother and need for help. However, information is lacking on men with ED who need help but do not seek medical attention. Thus, this study aimed to assess the distribution of bother, acceptance, and need for help in men with ED, and assess characteristics of patients with ED in need for help but not receiving medical attention for ED. METHODS A total of 5,721 men aged 18 years and older and registered in 12 general practices in the middle of the Netherlands were sent a questionnaire by mail about sexual problems, ED, need for help, and medical attention. Out of 2,117 questionnaires that were returned, 1,481 were completed on ED, bother, and need for help. RESULTS The prevalence of ED (according to World Health Organization definition) in the 1,481 men was 14.2%. Of these men 67.3% were bothered, 68.7% did not accept ED, and 85.3% wanted help. Surprisingly, 41.9% of men who denied a need for help were bothered and 19.4% did not accept ED. Only 10.4% of men with ED received any medical care. Bother in men with ED was related to increasing age (decreasing above 60 years). Compared with men who already received help for ED, men who wanted help but did not receive it more often suffered from diabetes, neurological problems, and various cardiovascular problems. On the other hand, history of myocardial infarction increased the chance of getting adequate medical attention for ED. CONCLUSIONS The majority of men with ED are concerned or bothered and perceive a need for help. Most of them do not receive any medical attention. These men are characterized by chronic medical conditions, visiting the physician's office regularly for their medical condition.
Muscle involvement in juvenile idiopathic arthritis.

OBJECTIVE An observational study of changes in muscle structure and the relation to muscle strength in juvenile idiopathic arthritis (JIA). METHODS Fifteen children and teenagers (eight girls and seven boys) with JIA, aged 9-19 yr (mean age 16.1), were studied. Muscle biopsies were obtained from the anterior tibial muscle and were examined using histopathological and immunohistochemical methods. Muscle fibre types were classified and fibre areas measured. As markers of inflammation, the major histocompatibility complex (MHC) class I and class II and the membrane attack complex (MAC) were analysed. Results were compared with biopsies from the gastrocnemius muscle in 33 young (19-23 yr) healthy controls. Isometric and isokinetic muscle strengths were measured in ankle dorsiflexion. Strength was compared with reference values for healthy age-matched controls. Nerve conduction velocities were recorded in the peroneal and sural nerves. RESULTS Four of the 15 muscle biopsies were morphologically normal. Eleven biopsies showed minor unspecific changes. Two of these also showed minor signs of inflammation. MHC class II expression was found in 4/15 patients, which was significantly more than in the healthy controls (P = 0.0143). The expression of MHC class I and MAC did not differ from that in the controls. The mean area of type I fibres was lower than that of type IIA fibres in 12/13 biopsies. Muscle strength was significantly reduced in the patient group. There was a significant positive correlation between muscle fibre area and muscle strength. Nerve conduction studies were normal in all cases. CONCLUSIONS Changes in leg muscle biopsies appear to be common in children and teenagers with JIA. The presence of inflammatory cells in the muscle and expression of MHC class II on muscle fibres may be a sign of inflammatory myopathy. There are no findings of type II muscle fibre hypotrophy or neuropathy, as in adults with RA.
Hubungan pengaruh gaya kepimpinan tranformasional terhadap perlaksanaan program pelan penggantian dalam perkhidmatan awam Malaysia

A systematic succession planning program, coupled with solid career development is important to public employees. Based on the Social Cognitive Career Theory (1979), Gould’s career planning model, and goal-setting theory, previous studies reveal that there is a relationship between career development and top management support. Thus, to groom future leaders, it is of utmost important for organizations not to rely only on the systematic succession planning programs; but also to have full commitment from the top management. Therefore, this study intends to explore the relationship between leadership characteristic styles and succession planning program implementation in the public sector in Malaysia. Four dimensions of transformational leadership characteristic were used, namely idealized influenced, inspirational motivation, individualized influence and intellectual stimulation. Additionally, two dimensions that measure succession planning which are career development and preparation of future leaders were also used. A combination of quantitative and qualitative methods was advocated in this study. Quantitative research design was employed by distributing survey questionnaires to 576 Malaysian Public Sector government servants from Grade 48 to 54, and (425 questionnaires were returned). Qualitative data was gathered from an elite interview which included seven top organizational leaders from various public agencies. Based on multiple regression analysis, the findings demonstrate that motivational inspiration, individualized influence and intellectual stimulation are significantly related to succession planning program. Thematic analysis which is based on qualitative data is also consistent with the quantitative finding which attests that leadership styles influence the successful implementation of succession planning programs in the public sector. Therefore, public sector needs to pay attention to leadership styles of top management so that succession planning program can be implemented successfully.
Interleukins and their antagonists but not TNF and its receptors are released in post‐ERP pancreatitis

Objective Usually it is not possible to study the initial systemic response in patients with acute pancreatitis in the first hours after onset of the disease. We used post-endoscopic retrograde pancreatography (ERP) pancreatitis as a model to study cytokine and anti-cytokine release in the early phase of human acute pancreatitis. Methods Post-ERP pancreatitis was defined as a threefold increase in serum amylase and at least two of the following clinical symptoms: abdominal pain, nausea, vomiting or peritonism 24 h after ERP. Serum levels of pro-inflammatory cytokines interieukin-1 β (IL-1 β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumour necrosis factor alpha (TNF), as well as endogenous antagonistic mediators of the systemic inflammatory response such as soluble tumour necrosis factor alpha receptors p55 (TNFR p55) and p75 (TNFR p75), and IL-1-receptor antagonist (IL-1-RA) and interleukin-2-receptor (IL-2R) as indicators of lymphocyte activation were measured before and 0,1, 4,12, 24 and 48 h after ERP. In nine patients with acute post-ERP pancreatitis, these parameters were monitored daily until C-reactive protein (CRP) was within normal ranges and were compared to patients without pancreatitis after ERP. Results IL-1 β was not detectable in five patients with and four patients without post-ERP pancreatitis. The values of the remaining patients in both groups were lower than 3.9 pg/ml. IL-8 and IL-1-RA serum concentrations peaked 12 h after ERP (132.9 and 3245.0 pg/ml respectively) compared to patients without post-ERP pancreatitis (25.8 and 389.9 pg/ml respectively). The IL-6 concentration increased to 81.6 pg/ml (8.0 pg/ml in control patients) 24 h after ERP, while the peak values for CRP were measured 72 h after ERP (164.0 versus 7.7 mg/l). IL-2R content was maximally elevated 144 h after ERP (688.8 versus 255.9 U/ml), while concentrations of TNF and its receptors showed no significant change over time. Conclusion The initial response of the cytokine network to damage of the human pancreas leading to acute pancreatitis includes the release of IL-8 and the IL-1 β antagonist IL-1-RA, while IL-1 β is not found in the systemic circulation. The TNF system does not seem to be involved as indicated by the lack of detectable changes in TNF and the soluble TNFR p55 and p75 serum concentrations. Lymphocyte activation as indicated by elevated IL-2R levels occurred days after the initial trauma. Even mild post-ERP pancreatitis leads to significant systemic release of cytokines and their biological counterparts.
Exploring Korean Middle School Students’ View about Scientific Inquiry

Background:The aim of this study is to examine Korean middle school students’ view about scientific inquiry with the Views About Scientific Inquiry (VASI) Questionnaire.Material and methods:This instrument deals with 8 aspects of scientific inquiry. 282 Korean middle school students participated in this study, and their responses were classified as informed, mixed, and naive.Results:The results revealed that Korean middle school students primarily held mixed or naive views about scientific inquiry. To discover why students held these views, their responses were analyzed in detail. For instance, they did not understand the meaning of ‘experiment’, ‘scientific’, ‘data’, and ‘evidence’ well. They understood scientific terminology and scientific inquiry in everyday contexts. Students also tended to regard science process skill as scientific method.Conclusions:In general, Korean middle school students held mixed or naive views about scientific inquiry. According to the results mentioned above, explicit and reflective instruction is necessary to develop students’ views about scientific inquiry.
Absence of symptomatic benefit of lansoprazole, clarithromycin, and amoxicillin triple therapy in eradication of Helicobacter pylori positive, functional (nonulcer) dyspepsia

OBJECTIVES:The aim of this study was to compare the effect of a combination of lansoprazole, clarithromycin, and amoxicillin (LCA) versus placebo on the severity of symptoms in functional dyspepsia patients who were positive for Helicobacter pylori (H. pylori). METHODS:This was a double-blind, randomized, controlled clinical trial in adult patients with functional dyspepsia who were H. pylori positive. Patients were randomized to 7-day treatment with LCA or identical looking placebo. H. pylori status was confirmed by the urea breath test performed at baseline, at 6 wk, and at 6 and 12 months. The severity of eight upper GI symptoms was measured on a five-point Likert scale. The main outcomes were the change in average severity of the dyspepsia summary score of the eight symptoms and the proportion of patients who improved ≥4 points on the dyspepsia summary score.RESULTS:A total of 157 patients were included in the intention-to-treat analysis. LCA achieved cure of H. pylori infection in 82% of patients compared to 6% in the placebo group. The severity of dyspepsia symptoms improved over the 12-month study period, but for none of the outcome measures was there a significant difference between LCA and placebo.CONCLUSION:There was no difference in sustained improvement of dyspepsia symptoms when LCA was compared with placebo. An 82% cure rate of H. pylori infection was observed with LAC.
Infant mortality in Europe, socio-economic determinants based on aggregate data

ABSTRACT A great deal of research has been conducted on the determinant factors of infant mortality. In this work, the focus is placed on the aggregate determinants of infant mortality in the EU. Data is collected from Eurostat and World Health Organization – Health for All databases for the period 2005-12. Robust regressions and panel data regressions are estimated in order to test the main determinants of infant mortality in the EU. Both the GDP and birth before the age of 20 influence infant mortality rate. It is likely that as mothers mean age at the first child increases, the rate of infant mortality decreases. The results found here contribute to the discussion on the factors explaining infant mortality in Europe and to future health policy. In particular, controlling teen motherhood may help to reduce infant mortality rate in the EU.
Single channel properties of cloned NMDA receptors in a human cell line: comparison with results from Xenopus oocytes.

1. Human embryonic kidney (HEK) 293 cells were transiently transfected with cDNAs encoding the NR1a‐NMDA epsilon 1[NR2A] subunit combination of the NMDA receptor. Single channel behaviour was recorded from outside‐out membrane patches, with the aim of comparing the results with those, recorded under the same conditions, from Xenopus oocytes injected with messenger RNA coding for the NR1a‐NR2A combination. 2. Single channels in HEK 293 cells showed a main conductance level of 51.4 +/‐ 2.4 pS, compared with 50.1 +/‐ 1.4 pS for channels in oocytes. A subconductance level of 38.1 +/‐ 2.1 pS was found in HEK 293 cells, compared with 38.3 +/‐ 1.3 pS in oocytes. The frequencies of transitions between the shut and the two conductance levels were also very similar. 3. Distributions of shut times could be fitted with five exponential components. In HEK 293 cells the first three of these components had time constants of 39 +/‐ 4 microseconds, 0.54 +/‐ 0.04 ms and 9.94 +/‐ 1.3 ms; in oocytes the values were 69 +/‐ 35 microseconds, 0.54 +/‐ 0.15 ms and 6.53 +/‐ 4.6 ms, respectively. The relative areas of the components were also similar in the two systems. 4. The distribution of all apparent open times for the sublevels was fitted with two exponential components giving time constants of 0.18 +/‐ 0.02 ms and 1.31 +/‐ 0.17 ms (for HEK cells) or of 0.31 +/‐ 0.36 ms and 1.31 +/‐ 1.1 ms (for oocytes). (ABSTRACT TRUNCATED AT 250 WORDS)