Miracle-dz/UniFAR-FTUs huggingface dataset:
Aeromagnetic data in the UK: a study of the information content of baseline and modern surveys across Anglesey, North Wales

A number of modern, multiparameter, high resolution airborne geophysical surveys (termed HiRES) have been conducted over the past decade across onshore UK. These were undertaken, in part, as a response to the limited resolution of the existing UK national baseline magnetic survey data set acquired in the late 1950s and early 1960s. Modern magnetic survey data, obtained with higher precision and reduced line spacing and elevation, provide an improved data set; however the distinctions between the two available resources, existing and new, are rarely quantified. In this contribution we demonstrate and quantify the improvements that can be anticipated using the new data. The information content of the data sets is examined using a series of modern processing and modelling procedures that provide a full assessment of their resolution capabilities. The framework for the study involves two components. The first relates to the definition of the shallow magnetic structure in relation to an ongoing 1:10 k and 1:50 k geological map revision. The second component relates to the performance of the datasets in defining maps of magnetic basement and assisting with larger scale geological and structural interpretation. One of the smaller HiRES survey areas, the island of Anglesey (Ynys Mon), off the coast of NW Wales is used to provide a series of comparative studies. The geological setting here is both complex and debated and cultural interference is prevalent in the low altitude modern survey data. It is demonstrated that successful processing and interpretation can be carried out on data that have not been systematically corrected (decultured) for non-geological perturbations. Across the survey area a wide number of near-surface magnetic features are evident and are dominated by a reversely magnetized Palaeogene dyke swarm that extends offshore. The average depth to the upper surfaces of the dykes is found to be 44 m. The existing baseline data are necessarily limited in resolving features 3 km to upper surface) assessments of magnetic basement. This further assessment is successfully provided by the larger scale baseline data which locates and defines a mid-crustal magnetic basement feature, centred beneath the Snowdon Massif, and illustrates that basement of similar characteristic extends beneath much of Anglesey.
Is Deep Learning an RG Flow?

Although there has been a rapid development of practical applications, theoretical explanations of deep learning are in their infancy. A possible starting point suggests that deep learning performs a sophisticated coarse graining. Coarse graining is the foundation of the renormalization group (RG), which provides a systematic construction of the theory of large scales starting from an underlying microscopic theory. In this way RG can be interpreted as providing a mechanism to explain the emergence of large scale structure, which is directly relevant to deep learning. We pursue the possibility that RG may provide a useful framework within which to pursue a theoretical explanation of deep learning. A statistical mechanics model for a magnet, the Ising model, is used to train an unsupervised RBM. The patterns generated by the trained RBM are compared to the configurations generated through a RG treatment of the Ising model. We argue that correlation functions between hidden and visible neurons are capable of diagnosing RG-like coarse graining. Numerical experiments show the presence of RG-like patterns in correlators computed using the trained RBMs. The observables we consider are also able to exhibit important differences between RG and deep learning.
A Model to Search for Synthesizable Molecules

Deep generative models are able to suggest new organic molecules by generating strings, trees, and graphs representing their structure. While such models allow one to generate molecules with desirable properties, they give no guarantees that the molecules can actually be synthesized in practice. We propose a new molecule generation model, mirroring a more realistic real-world process, where (a) reactants are selected, and (b) combined to form more complex molecules. More specifically, our generative model proposes a bag of initial reactants (selected from a pool of commercially-available molecules) and uses a reaction model to predict how they react together to generate new molecules. We first show that the model can generate diverse, valid and unique molecules due to the useful inductive biases of modeling reactions. Furthermore, our model allows chemists to interrogate not only the properties of the generated molecules but also the feasibility of the synthesis routes. We conclude by using our model to solve retrosynthesis problems, predicting a set of reactants that can produce a target product.
Effect of Motivation Versus De-motivation on Job Satisfaction among the Nurses Working in Hera General Hospital at Makkah Al-Mukramh

Background: The word "motivation" is derived from the Latin "mover" which means "to move". Motivation refers to psychological forces which move people, bring them into action and keep them going. Motivational psychology is about covert psychological processes that are assumed to explain which behavior or action an individual performs at each moment in time. Motivation explains the degree of effort that is spent while performing an activity, the level of performance in achievement tasks and the satisfaction and well-being that is derived from an activity and/or its outcome(s). Aim: The aim of the current study was to investigate the effect of motivation versus de-motivation on job satisfaction among the nurses working in Hera General Hospital. Study design: It was a descriptive correlational design. Subjects and Methods: A convenient sample composed of 70 nurses who were working in Hera General Hospital at Makkah Al-Mukramh, affiliated to the Ministry of Health in Kingdom of Saudi Arabia. Tools of data collection: A Self –Administered Questionnaire, it was` consisted of four parts, the first part was concerned with the demographic data of the nurses, the second part about job satisfaction related to administrative policies, supervision, working condition and doing enjoy job, the third part about motivation and de-motivation,the fourth part was related to job satisfaction and its effect on job. Results: The current study indicated that the majority of nurses were female and nearly half of them were single and their ages were ranged from 20-< 25 years old, and they had 2< 5 years of experience. The majority of nurses were satisfied with their jobs. Conclusion: Motivation is considered to be the best way to achieve job satisfaction and to reduce de-motivation. Whereas, the more nurses were motivated, the more they were satisfied with their jobs. Recommendations: Financial incentives will increase the levels of job satisfaction among nurses. Also, the hospitals and other institutions are need to know how to motivate their nurses to keep them from burning out or being de-motivated. [Sahar M. M. Aly Ahmed, Lamiaa A. Elsayed and Nahed S. El-Nagger. Effect of Motivation Versus Demotivation on Job Satisfaction among the Nurses Working in Hera General Hospital at Makkah AlMukramh. Life Sci J 2013;10(2):450-457]. (ISSN: 1097-8135). http://www.lifesciencesite. com. 67 Keyword: Motivation, de-motivation, job satisfaction.
Online physician reviews: is there a place for them?

Abstract Web-based physician ratings are increasingly popular but imperfect proxies for clinical competence. Yet they provide valuable information to patients and providers when taken in proper context. Providers need to embrace the reviews and use them to enact positive change in order to improve the quality of our patients’ experience. Patients need to realize the limitations of online ratings, particularly with smaller sample size and be discerning about the reasons behind the review.
Interleukin 1 is a key driver of inflammatory bowel disease-demonstration in a murine IL-1Ra knockout model

Interleukin 1 (IL-1) is an important mediator of inflammation and tissue damage in inflammatory bowel disease (IBD). The balance between IL-1 and IL-1Ra as a natural inhibitor plays a vital role in a variety of diseases. Here, we investigated whether changes seen during IBD are induced spontaneously in mice lacking a functional IL-1rn gene. Histological staining was performed on the jejunum and ileum of BALB/c IL-1rn+/+ and IL-1rn-/- mice to characterize crypt-villus height, villus width, and number of goblet cells per villus. Pro-inflammatory cytokines, immune cell infiltration and matrix-degrading enzymes, together with the production of intestinal enzymes and the integrity of tight and adherent junction proteins were determined using immunohistochemistry. In the small intestine of BALB/c IL-1rn-/- mice the villus heights were significantly reduced; and in the ileum this was accompanied by a decrease in villi width. There was also an increase in goblet cell number and mucin production compared to wild-type mice. IL-1α and IL-1β immunopositivity were increased, whilst IL-1R1 expression was decreased in IL-1rn-/- mice. IL-15 and TNFα were also increased in older IL-1rn-/- mice. Increased polymorphonuclear and macrophage infiltration were seen in IL-1rn-/- mice, whilst expression of matrix-degrading enzymes and digestive enzymes were unchanged, except for dipeptidyl peptidase IV which was increased in younger IL-1rn-/- mice compared to wild type mice. The expression of tight and adhesion junctions were also dramatically decreased in IL-1rn-/- mice. In conclusion, IL-1rn-/- mice developed spontaneous abnormalities which displayed features associated with IBD, demonstrating a clear role for IL-1 in IBD.
Notch Signaling in Human Neuroblastoma Cells

Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. Hash-1 is a component of the Notch signaling cascade, which is involved in many cell fate decisions. In general, Notch activity maintains a pool of undifferentiated cells and dysregulated Notch signaling has been linked to development of several cancers. It has been shown that the Notch cascade is transiently induced during neuroblastoma cell differentiation in vitro and that persistent Notch expression inhibits this differentiation. These observations imply a role for Notch signaling in the blocked differentiation of neuroblastoma cells. In addition, neuroblastoma cells exposed to hypoxia, a common event of solid tumors, dedifferentiate. During this process, components of the Notch signaling cascade are up regulated. In this thesis we show that Hash-1 interacts with ubiquilin-1, a protein involved in protecting proteins from degradation. In addition, we show that valproic acid (VPA) induces differentiation of neuroblastoma cells by modulation of the Notch signaling cascade. Aberrant signaling through the EGF receptor is involved in the genesis of some human cancers. Several reports have shown cross talk between EGFR signaling and the Notch cascade. We show here that the Notch target Hes-1 can be directly regulated by Ras/MAPK signaling at both normoxia and hypoxia, without the activation of Notch receptors. (Less)
Mexican American Adolescent Mothers’ Lived Experience: Grounded Ethnicity and Authentic Mothering

We conducted this qualitative, phenomenological study to further understanding of how second-generation Mexican American adolescent mothers perceive their young motherhood experience, drawing on the context of their Mexican heritage background. Through in-person interviews with 18 young mothers, we discerned shared essential meanings reconstructed around two major domains: (a) grounded ethnicity, a firm desire to remain true to and share their heritage culture, and (b) authentic mothering, strong relationality to their infants. We found that young mothers embraced their Mexican heritage mothering approaches, such as fostering familismo, valuing family above other obligations. The adolescents in this study sensed their young motherhood as an opportunity to protect and improve qualities of traditional familial cultural heritage, while absorbing elements of American culture to enhance the future for themselves and their infants. We discuss how providers can help reduce stigmatization and promote self-efficacy by respecting and partnering with young mothers to provide culturally congruent services.
Autologous Chondrocyte Implantation “Segmental-Sandwich” Technique for Deep Osteochondral Defects in the Knee: Clinical Outcomes and Correlation With Magnetic Resonance Imaging Findings

Background: Symptomatic osteochondral defects are difficult to manage, especially in patients with deep (>8-10 mm) empty defects. The restoration of articular congruence is crucial to avoid the progression to osteoarthritis (OA). Purpose: To describe the autologous chondrocyte implantation (ACI) “segmental-sandwich” technique for restoration of the osteochondral unit and to evaluate midterm outcomes in patients treated with this procedure. Correlations between magnetic resonance imaging (MRI) and radiographic findings with outcomes were assessed. Study Design: Case series; Level of evidence, 4. Methods: Outcomes were evaluated for a consecutive cohort of 15 patients with symptomatic deep (>8 mm) osteochondral lesions who underwent autologous bone grafting plus the ACI segmental-sandwich technique performed by a single surgeon between 2003 and 2011. Patients with a minimum 2-year follow-up were included. All patients completed validated clinical outcome scales and a patient satisfaction survey. The Kellgren-Lawrence (K-L) grade was assessed for the progression to OA. The repair site was evaluated with the MOCART (magnetic resonance observation of cartilage repair tissue) score. Filling and tissue characteristics of the bone defect were analyzed with MRI. Results: All patients (mean age at surgery, 31.0 ± 9.1 years) were available for follow-up (mean follow-up, 7.8 ± 3.0 years; range, 2-15 years). The mean chondral lesion size was 6.0 ± 3.5 cm2 (range, 1.5-13.5 cm2), with a mean bone defect area of 1.7 cm2 (27%-40% of overall surface area treated by ACI) and depth of 1.0 cm. All patients had successful clinical outcomes, and all functional scores improved significantly (P < .05). Patients reported a very high satisfaction rate (93%). The K-L grade demonstrated no significant progression to OA over a mean follow-up of 4.7 years. For 12 patients with MRI results available, the mean MOCART score at a mean of 3.3 years was 64.2 ± 19.9, with complete or near-complete (≥75% of defect volume) chondral defect filling (83%) and complete integration to adjacent cartilage (83%). Bone defects were completely filled in 83% of patients. Conclusion: The ACI segmental-sandwich technique provides significant functional improvements at midterm follow-up and excellent survival rates. This unique treatment allows for the resurfacing of cartilage defects and the repair of underlying segmental bone lesions.
Hydrological connectivity from glaciers to rivers in the Qinghai–Tibet Plateau: roles of suprapermafrost and subpermafrost groundwater

The roles of subsurface groundwater flow in the hydrological cycle within the alpine area characterized by permafrost and/or seasonal frost are poorly known. We studied the role of permafrost in controlling groundwater flow and the hydrological connections between glaciers in high mountain and river in the low plain with hydraulic head, temperature, geochemical, and isotopic data. The study area was a catchment in the headwater region of the Heihe River in the northeastern Qinghai-Tibet Plateau. The groundwater in the high mountains mainly occurs as suprapermafrost groundwater, and in the moraine and fluvio-glacial deposits on the planation surfaces of higher hills suprapermafrost, intrapermafrost, and subpermafrost groundwater co-occur. Glacier and snow-meltwater are transported from the high mountains to the plain through stream channels, slope surfaces, and supra- and subpermafrost aquifers. Groundwater in the Quaternary aquifer under the piedmont plain is recharged by the lateral inflow from permafrost groundwaters and the infiltration of streams, and is discharged as baseflow to the stream in the north. Groundwater maintained stream flow over the cold season and significantly contributed to the stream flow during the rainy season. 3 H and 14 C data indicated that the age of supra- and sub-permafrost groundwater, and groundwater in Quaternary aquifer of seasonal frost zone, ranges from 30–60 years. Two proposed mechanisms contribute to seasonal variation of the aquifer water-conduction capacity: (1) surface drainage through the stream channel during the high-flow period, and (2) subsurface drainage to an artesian aquifer confined by stream icing and seasonal frost during the cold season.
Catalytically Important Residues in E. coli 1-Deoxy-D-Xylulose 5-Phosphate Synthase

1-deoxy-D-xylulose 5-phosphate synthase (DXS) catalyzes the initial step of the 2-C-methyl-D- erythritol 4-phosphate (MEP) pathway consisting in the condensation of (hydroxiethyl)thiamin derived from pyruvate with D-glyceraldehyde 3-phosphate (GAP) to yield 1-deoxy-D-xylulose 5-phosphate (DXP). The role of the conserved residues H49, E370, D427 and H431 of E. coli DXS was examined by site-directed mutagenesis and kinetic analysis of the purified recombinant enzyme mutants. Mutants at position H49 showed a severe reduction in their specific activities with a decrease of the kcat/KM ratio by two orders of magnitude lower than the wild-type DXS. According to available structural data residue H49 is perfectly positioned to abstract a proton from the donor substrate. Mutations in DXS E370 showed that this residue is also essential for catalytic activity. Three-dimensional structure supports its involvement in cofactor deprotonation, the first step in enzymatic thiamin catalysis. Results obtained with H431 mutant enzymes indicate that this residue plays a role contributing to transition state stabilization. Finally, mutants at position D427 also showed a severe specific activity decrease with a reduction of the kcat/KM ratio. A role in binding the substrate and selecting the stereoisomer is proposed for D427.
Treatment of a Recurrent Periprosthetic Joint Infection with an Intramedullary Knee Arthrodesis System with Low-Amount Metallic Silver Coating

We present a case of a recurrent periprosthetic knee infection treated with an intramedullary arthrodesis system coated with low amounts of metallic silver. After a follow-up of 26 months, the patient remained infection free and no silver-related complications were detected. Silver serum concentrations remained below the detection limit of 2 ppb.
A Fine-grained Large-scale Analysis of Coreference Projection

We perform a fine-grained large-scale analysis of coreference projection. By projecting gold coreference from Czech to English and vice versa on Prague Czech-English Dependency Treebank 2.0 Coref, we set an upper bound of a proposed projection approach for these two languages. We undertake a detailed thorough analysis that combines the analysis of projection’s subtasks with analysis of performance on individual mention types. The findings are accompanied with examples from the corpus.
Cultural institutions in the digital age: British Museum’s use of Facebook Insights

Over the last decade, museums have experienced a strong cultural shift from objectoriented towards audience-oriented strategic approaches. This paper reviews the relevant literature on this transition and provides supportive evidence of the impact that social media have upon the relationship between cultural organisations and their audiences. Data deriving from the use of the British Museum’s Facebook page provides a comprehensive evaluation of the museum’s general social media strategy. Given the dominance and widespread use of Facebook and other social media, the degree of engagement of cultural organisations with them, seem to have become an inseparable factor on the scale of effectiveness of the relation with their audiences and the levels of visitor attendance. This research aims, by using one of the most prestigious museums in Britain as a case study, to provide an initial comprehensive set of insights into the use of social media by cultural organisations. The findings of this study are based on research conducted for the first author’s postgraduate studies at the Centre for Digital Humanities, Department of Information studies, University College London.
Communicative Intention in Code Review Questions

During code review, developers request clarifications, suggest improvements, or ask for explanations about the rationale behind the implementation choices. We envision the emergence of tools to support developers during code review based on the automatic analysis of the argumentation structure and communicative intentions conveyed by developers' comments. As a preliminary step towards this goal, we conducted an exploratory case study by manually classifying 499 questions extracted from 399 Android code reviews to understand the real communicative intentions they convey. We observed that the majority of questions actually serve information seeking goals. Still, they represent less than half of the annotated sample, with other questions being used to serve a wider variety of developers' communication goals, including suggestions, request for action, and criticism. Based on our findings we formulate hypotheses on communicative intentions in code reviews that should be confirmed or rejected by follow-up studies.
Treatments for patients with advanced neuroendocrine tumors: a network meta-analysis

Background: It remains unknown which is the most effective regimen among the available therapies for advanced well-differentiated neuroendocrine tumors (NETs). We performed a network meta-analysis to address this important issue. Methods: PubMed, Embase, Web of Science, Cochrane Library, and major international scientific meetings were searched for relevant randomized controlled trials (RCTs). Progression-free survival (PFS) data was the primary outcome of interest, and overall survival (OS) and serious adverse events (SAEs) were the secondary outcomes of interests, reported as hazard ratio (HR), or odds ratio (OR) and 95% confidence intervals (CIs). Results: Included in the meta-analysis were 21 eligible articles reporting 15 RCTs with a total of 2922 patients randomized to receive 11 treatments. Peptide receptor radionuclide therapy (PRRT) showed significant PFS advantage over somatostatin analogs (SSA) (HR = 0.21, 95% CI: 0.11–0.41), everolimus (HR = 0.25, 95% CI: 0.11–0.53), sunitinib (HR = 0.29, 95% CI: 0.10–0.82), everolimus+SSA (HR = 0.26, 95% CI: 0.12–0.54), and everolimus+bevacizumab (HR = 0.31, 95% CI: 0.11–0.82). OS findings were not significantly different between treatments. In terms of treatment rankings of PFS, PRRT had the highest probability (96%) of being the most effective treatment, followed by SSA+bevacizumab (86%) and SSA+interferon-α (IFN-α) (78%). As for toxicity, risk of SAEs was similar between the three treatments. Based on the benefit–risk ratio, PRRT, SSA+bevacizumab, and SSA+IFN-α seemed to be the best, second-, and third-best treatment, respectively. Conclusions: PRRT is likely to be the most preferable treatment for patients with advanced well-differentiated NETs. SSA+bevacizumab and SSA+IFN-α also seem to be more effective regimens with limited risk of SAEs.