Miracle-dz/UniFAR-FTUs huggingface dataset:
Macula Precise Localization Using Digital Retinal

The fovea is a spot located in the center of the macula, and responsible for sharp central vision. In this paper a method to detect the macula location and size is presented, as a first step towards the fovea location. Prior to the macula detection, the optic disk size and position is computed. This is performed through the combination of two stages: firstly, a clustering algorithm is used to select the regions which contain the pixels with the highest gray levels. A correlation filter is applied to these regions to compute the approximate center of the optic disk. Then, in order to extract the optic disk, a deformable model which is used. Then, following the morphological properties of the eye, the macula location and size is determined by means of a new correlation filter. Search with this filter is performed in a reduced area of interest, whose size and position is determined by means, again, of the morphological properties of the eye. The algorithm has proven to be fast and accurate in the set of test images, composed by 135 digital retinal images, where the tests have been performed by comparing our results with those obtained by two expert clinicians from two different hospital centers. Key–Words:Optic disk, macula, fovea, correlation filter, deformable model.
Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study.

PURPOSE KEYNOTE-158 ( ClinicalTrials.gov identifier: NCT02628067) is a phase II basket study investigating the antitumor activity and safety of pembrolizumab in multiple cancer types. We present interim results from patients with previously treated advanced cervical cancer. PATIENTS AND METHODS Patients received pembrolizumab 200 mg every 3 weeks for 2 years or until progression, intolerable toxicity, or physician or patient decision. Tumor imaging was performed every 9 weeks for the first 12 months and every 12 weeks thereafter. The primary end point was objective response rate (ORR), assessed per Response Evaluation Criteria in Solid Tumors (version 1.1) by independent central radiologic review. Safety was a secondary end point. RESULTS Ninety-eight patients were treated. Median age was 46.0 years (range, 24 to 75 years), and 65.3% of patients had Eastern Cooperative Oncology Group performance status of 1. Eighty-two patients (83.7%) had programmed death-ligand 1 (PD-L1)-positive tumors (combined positive score ≥ 1), 77 having previously received one or more lines of chemotherapy for recurrent or metastatic disease. Median follow-up was 10.2 months (range, 0.6 to 22.7 months). ORR was 12.2% (95% CI, 6.5% to 20.4%), with three complete and nine partial responses. All 12 responses were in patients with PD-L1-positive tumors, for an ORR of 14.6% (95% CI, 7.8% to 24.2%); 14.3% (95% CI, 7.4% to 24.1%) of these responses were in those who had received one or more lines of chemotherapy for recurrent or metastatic disease. Median duration of response was not reached (range, ≥ 3.7 to ≥ 18.6 months). Treatment-related adverse events occurred in 65.3% of patients, and the most common were hypothyroidism (10.2%), decreased appetite (9.2%), and fatigue (9.2%). Treatment-related grade 3 to 4 adverse events occurred in 12.2% of patients. CONCLUSION Pembrolizumab monotherapy demonstrated durable antitumor activity and manageable safety in patients with advanced cervical cancer. On the basis of these results, the US Food and Drug Administration granted accelerated approval of pembrolizumab for patients with advanced PD-L1-positive cervical cancer who experienced progression during or after chemotherapy.
Mechanical EXAMINING THE CURRENT OF DRILLING MUD IN A POWER SECTION OF THE SCREW DOWNHOLE MOTOR V

Screw down-hole motors (SDM) that are characterized by the relatively small specific metal consumption and the simplicity of design have been widely used at present for drilling horizontal, obliquely-directed, and vertical oil and gas wells. In addition, they are also applied when passing degasification wells in the complexes of methane extraction at coal deposits, post-exploration of mine fields of caustobiolith, development of thin off-balance oil reservoirs. The basic elements of SDM are a spindle section, a section of curvature (a tilt angle adjuster), a power section (stator and rotor), a rotor catcher (a catcher of the rotor in case of an accident), reverse and circulation valves; the power section is the only element responsible for torque. When pumping drilling mud through a power section, it presses on the rotor, causing it to rotate. The stator is a casing in the form of a pipe or a profiled pipe whose internal covering is made from elastomers, which are the polymers with high elastic properties in a broad temperature range (for example, abrasion resistant rubber, rubbers). Consequently, the rotor and the rubberized stator (Fig. 1) are the most responsible units of SDM upon which the overall efficiency and operability of a screw down-hole motor depends. A SDM rotor has a special profile with a preset step of the screw line. The split ratio of the working bodies section is determined by the ratio of the number of rotor and stator teeth Zr:Zst ö in contemporary engines it is from 1:2 to 9:10. In the process of operation the elastomeric stator covering accepts cyclically alternating loads, reactive moment and radial forces. The rotor and stator are exposed to chemical and mechanical effects from drilling mud. Mechanical EXAMINING THE CURRENT OF DRILLING MUD IN A POWER SECTION OF THE SCREW DOWN-HOLE MOTOR
PARTIAL TRANSFORMATION GROUPOIDS ATTACHED TO GRAPHS AND SEMIGROUPS

We introduce the notion of continuous orbit equivalence for partial dynamical systems, and give an equivalent characterization in terms of Cartan-isomorphisms for partial C*crossed products. Both graph C*-algebras and semigroup C*-algebras can be described as C*algebras attached to partial dynamical systems. As applications, for graphs, we generalize and explain a result of Matsumoto and Matui relating orbit equivalence and Cartan-isomorphism, and for semigroups, we strengthen several structural results for semigroup C*-algebras concerning amenability, nuclearity as well as simplicity of boundary quotients. We also discuss pure infiniteness for partial transformation groupoids arising from graphs and semigroups.
COLOUR STABILITY AND SURFACE DEFECTS OF NATURALLY AGED WOOD TREATED WITH TRANSPARENT PAINTS FOR EXTERIOR CONSTRUCTIONS

Wooden constructions and their parts in the exterior, e.g. houses, cottages, bowers, bridges, claddings, decking, windows or garden furniture, are degradable by bio-agencies, fire and weathering. Their service life can be increased by well-designed construction systems, by using of more durable wood species and composite materials, and also by convenient biocides and antiweathering paints. In experiments, the colour changes (valued by CIELab) and surface defects (valued at 10x magnification) in wood samples during their 3-year’s outdoor weathering at 45° were determined in an accordance with the EN 927-3 2000, taking into account these variable factors: 1) two wood species (black locust, Norway spruce); 2) four transparent coating systems (PerlColor, PerlColor + AquaStop, OsmoUV-Protection Oil 420, OsmoUV-Protection Oil 420 + AquaStop); 3) two roughness of wood (grinded with 60 or 120 sandpaper). Generally at natural weathering, the colours of the black locust wood untreated and treated with transparent paints were more stable than of the Norway spruce one. The OsmoUV-Protection Oil 420 ensured good colour stability to the black locust samples, and its combination with the AquaStop also to the Norway spruce ones. The top water repellent paint AquaStop put off degradation of the PerlColor and OsmoUV-Protection Oil 420 paints, with significant colour stability increase of the Norway spruce samples. A higher initial roughness of wood surfaces had usually a negative influence for the colour stability of coated wood and its surface quality.
EFEITOS DA SUPLEMENTAÇÃO COM ÁCIDO FÓLICO EM PRENHAS E SOBRE O DESENVOLVIMENTO DA PROLE SUBMETIDA AO MODELO DE HIPÓXIA Orientadora: Profa Dra

Folic acid (FA) supplementation (400 μg/day) has been recommended during pregnancy to prevent neural tube defects. However, in some countries, flours are required to be fortified with FA, possibly increasing the levels of this vitamin in pregnant women. Our previous studies have evidenced a dual effect of the FA treatment in a rat model of neonatal hypoxia-ischemia (HI). Aiming to better correlate with humans, this paper evaluated the effects of two different levels of FA supplementation during pregnancy on memory parameters and neuronal survival and plasticity in the hippocampus of rats submitted to the neonatal HI. During pregnancy, female Wistar rats received one of these diets: standard (SD), supplemented with 2 mg/kg of FA or with 20 mg/kg of FA. At the 7 PND, rats suffered the HI procedure. At the 60 PND rats were evaluated in the open field, Morris water maze, novel-object recognition and inhibitory avoidance tasks. Furthermore, neuronal density, synaptophysin densitometry and BDNF concentration were assessed in the hippocampus. Both doses of FA prevented the HIinduced memory impairments. The supplementation reversed the BDNF late increase in the hippocampus of the HI rats, but did not inhibit the neuronal death. In conclusion, FA supplementation during pregnancy prevented memory deficits and BDNF imbalance after neonatal HI. These findings are particularly relevant because neuroprotection was achieved even in the high level of FA supplementation during pregnancy, indicating that this intervention would be considered secure for the offspring development. © 2018 Elsevier Inc. All rights reserved.
You Can’t Post That!

The use of social media by journalists raises new ethical and professional dilemmas. As a result, news outlets are implementing policies addressing what is and what is not permitted on social media platforms. Through a nationwide survey of local television (TV) news directors, this study examines the prevalence of social media policies in TV newsrooms, the source of those policies, and the application in newsrooms. This study provides a framework for newsroom policies and further empirical investigation. The authors identify and explore five areas to be used as guidelines in formulating newsroom social media policies: personal and professional social media activity of reporters, social media sourcing and content, audience complaints on social media, the use of social media while reporting in the field, and ownership of social media accounts. The authors investigate how the policies address emerging issues in each of those five areas and provide policy recommendations.
The Effect of Project Model through the Scientific Approach to the Ability to Prepare the Tools and Ingredients of Hydroponics Vegetables Cultivation of Deaf Students in Agriculture Skills Class SLB

The learning process of students with hearing impairment (deaf students) is adjusted to its characteristics. Agricultural skills are subjects that provide opportunities for students to gain experience in producing a product. This study aims to analyze the effect of project model through the scientific approach towards the ability to prepare tools and planting ingredients of hydroponic vegetables of Deaf students in farming skills class SLB Negeri Balikpapan. This research is Quantitative Pre-Experimental research with One Group Pretest-Posttest design. A pretest is performed prior to treatment. Posttest is performed to measure the effect of treatment. The number of samples in the study was 30 deaf students in SLB Negeri Balikpapan. The results showed that there was an increase in pretest-posttest average value as follows. 1) The project model obtained a pretest average of 47.83, post-test 79.17. 2) Ability to prepare the vegetable planting of hydroponics vegetables, the pretest average value was 48.30, and posttest was 80.27. 3) Scientific Approach, the average value of pretest was 49.40, posttest value was 78.07. 4) Ability to prepare planting vegetable hydroponics, the average value of pretest was 47.20, posttest was 80.33. Based on the data analysis, it can be concluded that: 1) The project model has the significant effect on the ability to prepare hydroponic vegetable apparatus of Deaf students in farming skill class of SLB Negeri Balikpapan. 2) The scientific approach has a significant effect on the ability to prepare hydroponic vegetable cultivation tools for Deaf students in farming skill class of SLB Negeri Balikpapan. 3) The project model has a significant effect on the ability to prepare the ingredients of Hydroponic vegetables of Deaf students in farming skill class SLB Negeri Balikpapan. 4) The scientific approach has a significant effect on the ability to prepare the ingredients of Hydroponic vegetables of Deaf students in the SLB Agricultural Skill class of Balikpapan State. 5) The project model through a scientific approach has a significant effect on the ability to prepare tools and ingredients of Hydroponic vegetables for Deaf students in farming skill class SLB Negeri Balikpapan.
Page Proof Instructions and Queries

In this article, we address the issue of targeted instruction on interpretive contrasts between native and second-language grammatical meanings. Such mismatches are predicted to create challenges for learners. We illustrate this with French and English pronouns. In French, clitic pronouns (le, la) point to human as well as inanimate referents, while English pronouns distinguish between human (him, her) and inanimate (it) referents. While other grammatical differences between English and French pronouns are taught, this interpretive mismatch attracts less attention in instructional materials. We review the pedagogical literature and report the results of a study investigating this knowledge in Anglophone learners of French as a second language (L2). We document that the mismatch is indeed challenging, particularly to beginning learners, and propose ways to overcome this difficulty.
ACUTE MYOCARDIAL INFARCTION ECG Changes After Alteplase Therapy in Patients with Acute Myocardial Infarction

INTRODUCTION: Fibrinolytic treatment has produced an important impact on the natural history of STelevation AMI (1) . The goal of thrombolytic therapy is to lyse occlusion by coronary thrombi and thus reinstate adequate coronary blood flow (2,3) . Over the past decade, the critical importance of timely reperfusion of the occluded infarctrelated coronary artery in patient with STelevation AMI has been recognized (4) . Early administration of thrombolytic agents reduces infarct size and improves survival (5,6) , with a reduction in the mortality by 25–50% (2,5,7,8) .
External ankle supports alter running biomechanics: a field-based study using wearable sensors

Objectives: To evaluate the effects of ankle taping, bracing, and fibular reposition taping (FRT) on running biomechanics as measured with wearable sensors. Approach: A randomized crossover study design was employed as 12 young adults (six males, six females) with history of ankle sprain completed four 400 m runs at self-selected pace on an outdoor track. One of four conditions (control, taped, braced, FRT) was applied prior to each run. RunScribe™ sensors were heel-mounted on each shoe and measured kinematic (maximum pronation velocity, pronation excursion), kinetic (braking and impact g) and spatiotemporal (cycle time, contact time, stride length, stride pace) variables. Main results: Compared to the control and FRT conditions, both the taped and braced conditions significantly restricted maximum pronation velocity (control: 767.8 ± 228.3° s−1; FRT: 721.2 ± 213.6° s−1; taped: 528.8 ± 193.6° s−1; braced: 562.1 ± 178.3° s−1) and pronation excursion (control: 17.1 ± 6.6°; FRT: 17.2 ± 6.6°; taped:11.9 ± 4.7°; braced: 12.9 ± 5.1°). Braking g were significantly higher in the control condition (12.1 ± 0.9 g) condition compared to the taped (11.6 ± 1.0 g) and braced (11.6 ± 1.2 g) conditions. Cycle time was significantly greater in the braced condition (677.8 ± 43.7 ms) compared to taped (669.3 ± 44.6 ms) and FRT (672.1 ± 44.2 ms) conditions. Significance: Ankle taping and bracing were shown to be comparable in decreasing ankle kinematics and kinetics, while FRT caused minimal changes in running biomechanics. Taping and bracing may be beneficial in stabilizing and protecting the ankle while FRT should not be used to restrict ankle motion during running.
THE EXPLOSIVE STRENGTH OF GIRLS OF A YOUNGER SCHOOL AGE UDC 796 . 41-055

Physical education (PE) at a younger school age is very important. But in practice, this course is not carried out regularly or is not performed by PE teachers. The problem of the research was to determine whether the developmental gymnastics program had an effect on the development of explosive strength with younger school age girls. The sample of participants for the experimental group consisted of 59 girls and for the control group 45 girls aged 9 to 11. To determine the level of explosive strength three tests were used. Data processing was performed by the statistical program SPSS v. 20. For all the data, the parameters of descriptive statistics were calculated. To determine the differences between the groups, a t-test for independent samples was used with a calculation of significance of the size of the difference (Cohen's d). The research has shown the effects of the developmental gymnastics program on the development of explosive strength among girls aged 9 to 11. Differences in explosive strength were identified in favor of the experimental group in two out of the three variables. The results obtained accurately indicate that the participants included in the development gymnastics program have a significantly higher level of explosive strength than the participants who only attended PE classes.
A comparative study on the effect of music therapy alone and a combination of music and yoga therapies on the psychophysiological parameters of cardiac patients posted for angiography

Acceptance: 03-10-2018 ABSTRACT Background and Objectives: Patients undergoing cardiac catheterization and coronary angiography often experience high levels of anxiety and physiological disturbances. Music therapy and music interventions have been found to be effective in bringing down the anxiety and reducing the physiological disturbances for these patients. However, the efficacy of combination of music and yoga therapies for preprocedural anxiety and physiological disturbances needs to be studied. We aimed in this study to compare the effect of music therapy with the combination of music and yoga therapies to impact the psycho-physiological responses like anxiety, blood pressure, pulse rate and respiratory rate of patients who were posted for coronary angiography Material and Methods: A total of 45 patients who were posted for coronary angiography were included in the study and randomly divided into three groups. Music therapy group(n=16) received music listening intervention in the form listening to pre-recorded, patient-preferred, relaxing raga improvisational music for 15 minutes 1) on the previous day of angiography and 2) 15 minutes before being taken to the catheterization lab on the day of the angiography. The combination of music and the yoga group received both music therapy and yoga therapy in the form of pranava pranayama together for 15 minutes. The control group received only the standard medical treatment. The state of anxiety was measured by a five point single item Likert scale and the physiological measures such as systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse rate (PR) and respiratory rate (RR) were also recorded for the study Results: Both music therapy alone and the combination of music and yoga therapies resulted in within the group significant reduction in anxiety and respiratory rate and music therapy group recorded additionally significant reduction in SBP, DBP and PR scores during the period of intervention. Conclusion: Our findings indicate that music therapy alone can bring down the anxiety levels and reduce the physiological disturbances of patients posted for angiography. Also, combination of music and yoga therapies can bring down the anxiety levels and improve the deep breathing pattern for these patients posted for angiography. More studies are needed to confirm these findings.
Improved survival rates of AML patients following admission to the intensive care unit

Abstract Induction chemotherapy in AML patients may have life-threatening side effects requiring intensive care unit (ICU) treatment. We analyzed all AML patients receiving intensive chemotherapy at a single academic center between 01/2006-12/2016. At least one ICU admission was observed in 32% (76/240) patients, and 33% of those died following ICU admission. Whereas the ICU admission proportion remained stable, mortality after ICU admission decreased from 14% (2006–2008) to 3% (2014–2016; p = .056). The number of failing organ systems inversely correlated with surviving ICU admission (p < .001). Sepsis and renal, cardiac and pulmonary failure were each associated with higher mortality. With increasing ICU duration, survival probability decreased (p < .001), but remained >50% even after 14 days of ICU treatment. Progression-free and overall survival were comparable between ICU surviving patients and patients never needing ICU support. In conclusion, outcome after ICU admission of AML patients has substantially improved in recent years.
capiTal markeT research

This paper is a review and aims to present and interpret the results of previous research carried out in the context of reducing the problems associated with “scale effects” in capital market research. Evaluating the results of investigations in the field shows that deflating all the elements of the regression model using suitable deflator is the preferred approach of dealing with scale problem in research. However, there is no agreement among researchers on the best deflator and studies on scale effect sought to be continued.
Brain Changes during Phyletic Dwarfing in Elephants and Hippos

Of all known insular mammals, hippos and elephants present the extremes of body size decrease, reducing to 4 and a mere 2% of their ancestral mainland size, respectively. Despite the numerous studies on these taxa, what happens to their relative brain size during phyletic dwarfing is not well known, and results are sometimes conflicting. For example, relative brain size increase has been noted in the Sicilian dwarf elephant, Palaeoloxodon falconeri, whereas relative brain size decrease has been postulated for Malagasy dwarf hippos. Here, I perform an analysis of brain, skull, and body size of 3 insular elephants (Palaeoloxodon “mnaidriensis,” P. tiliensis, and P. falconeri) and 3 insular hippos (Hippopotamus madagascariensis, H. lemerlei, and H. minor) to address this issue and to test whether relative brain size in phyletic dwarf species can be predicted. The results presented here show that the encephalization of all insular elephants and hippos is higher than that of their continental relatives. P. falconeri in particular has an enormous encephalization increase, which has so far not been reported in any other insular mammal. Insular brain size cannot be reliably predicted using either static allometric or ontogenetic scaling models. The results of this study indicate that insular dwarf species follow brain-body allometric relationships different from the expected patterns seen for their mainland relatives.