Miracle-dz/UniFAR-FTUs huggingface dataset:
A pilot study of cognitive behavioral therapy in fibromyalgia.

BACKGROUND Fibromyalgia is a syndrome characterized by widespread musculoskeletal pain and multiple tender points as well as high levels of self-reported disability and poor quality of life. OBJECTIVES In this pilot study, a mind-body approach (cognitive-behavioral therapy) was tested that has been successful in treating chronic back pain patients to determine whether it would improve function, decrease perceived pain, and improve mood state for fibromyalgia patients. PARTICIPANTS 28 patients recruited from the greater Baltimore area. INTERVENTION Eight weekly sessions, 2 1/2 hours each, with three components: an educational component focusing on the mind-body connection, a portion focusing on relaxation response mechanisms (primarily mindfulness meditation techniques), and a qigong movement therapy session. MAIN OUTCOME MEASURES Data collection instruments were the Fibromyalgia Impact Questionnaire, the Health Assessment Questionnaire, the Beck Depression Inventory, the Coping Strategies Questionnaire, the helplessness subscale of the Arthritis Attitudes Index, the Medical Outcomes Study Short Form General Health Survey, and a double-anchored 100-mm visual analog scale to assess sleep. RESULTS Twenty patients completed the study. Standard outcome measures showed significant reduction in pain, fatigue, and sleeplessness; and improved function, mood state, and general health following an 8-week intervention. CONCLUSION A mind-body intervention including patient education, meditation techniques, and movement therapy appears to be an effective adjunctive therapy for patients with fibromyalgia.
The fate of C4d positive kidney allografts lacking histological signs of acute rejection.

BACKGROUND C4d deposits in renal transplants are known to be an independent risk factor of graft failure. The current analysis evaluates the impact of C4d deposits on graft function and survival in renal transplants without morphological signs of rejection. METHODS We retrospectively analyzed diagnostic transplant biopsies performed due to allograft dysfunction from June 1994 to June 2001 at the University Hospital in Basel. STUDY GROUP Grafts/patients with focal or diffuse positivity of C4d along peritubular capillaries; absence of morphological signs of acute cellular and/or humoral rejection; up to 3 year follow-up analysis post index biopsy. Patients treated with anti-rejection therapy or an increase in maintenance immunosuppression post biopsy (intervention group = IG) were compared to patients with unaltered immunosuppression (standard group = SG). RESULTS Study group: 22 biopsies/patients out of 400 biopsies (5%) were included into the study, 17 in the SG and 5 in the IG. Patient survival (1-/3-years): SG: 100/94%, IG: 80/80%; graft survival censored for death (1-/3-years): SG: 82.5/68.8%, IG: 100/100%; serum creatinine (micromol/l) at index biopsy/1-year/3-years: SG: 221 +/- 70/231 +/- 103/245 +/- 124, IG: 217 +/- 100/143 +/- 28/177 +/- 55; acute rejection episodes within 1 year post index biopsy: SG: 4 (4 patients), IG: 1 (1 patient); all differences not significant. Lowest serum creatinine within 4 weeks post index biopsy (IG vs. SG): 108 +/- 25 vs. 181 +/- 61, p = 0.02. CONCLUSIONS C4d positivity in kidney transplants lacking histological evidence of acute rejection is not associated with rapid functional graft deterioration, even in untreated cases. However, anti-rejection therapy results in the improvement of kidney function. Thus, even in grafts with normal histology, the detection of C4d in diagnostic biopsies can be interpreted as a sign of "smoldering" rejection that benefits from therapy.
Effects of the toe-only rocker on gait kinematics and kinetics in able-bodied persons

Rocker sole shoes are commonly prescribed to diabetic patients with insensate feet. Recent passage of the therapeutic shoe bill has drawn an increased focus on prescription of rehabilitative footwear. The purpose of this work is to investigate the dynamics of lower extremity joints (hip, knee, and ankle) with the application of a toe-only rocker sole shoe under controlled laboratory conditions. Forty (40) normal adults volunteered for gait analysis using controlled baseline and prescription toe-only rocker sole shoes. Three-dimensional motion analysis techniques were used to acquire kinematic and kinetic data using a six camera Vicon 370 motion system and two AMTI force plates. While significant changes from baseline to toe-only rocker were noted in cadence (increased) and stride length (decreased), no significant change in walking speed was observed. The most significant kinematic changes with the application of the toe-only shoe occurred at the ankle and knee in the sagittal plane during stance. The most significant kinetic effects were observed in the hip and knee during swing phase. Changes in power were noted at all joints, mostly in terminal stance. These kinematic and kinetic changes, along with previously studied effects of pressure relief at the metatarsal heads, should aid medical professionals in prescribing prophylactic footwear.
The 12C/13C Isotope Gradient Derived from Millimeter Transitions of CN: The Case for Galactic Chemical Evolution

New measurements of 12C/13C ratios in Galactic molecular clouds have been conducted using the N = 1 → 0 transition of the CN radical. This species is unique in that it has extensive hyperfine structure that can be accurately used to correct for line saturation effects. Combined with the past observations of Savage and coworkers, the ratios derived from CN are the most extensive data set to date for molecular clouds, and they include sources that lie in the range of 0.09-16.41 kpc in distance from the Galactic center (DGC). The ratios derived from CN indicate a gradient with Galactic distance of 12C/13C = 6.01DGC + 12.28. This gradient agrees rather closely with those derived from measurements of CO and H2CO. The least-squares fit to all data points for the three molecules is 12C/13C = 6.21DGC + 18.71. CO, CN, and H2CO are synthesized from quite varied reactions, and any 13C fractionation must follow different pathways for these three species. The relatively good agreement between the 12C/13C ratios of the three molecules, as well as their lack of correlation with gas kinetic temperature, suggests that chemical fractionation and isotope-selective photodissociation both do not play a substantial role in influencing such ratios. Therefore, the 12C/13C gradient found in the Galaxy is a true indicator of Galactic chemical evolution. The apparent discrepancy between the solar system (12C/13C = 89) and local interstellar medium values (12C/13C ≈ 68) of this ratio may be a result of 13C enrichment since the formation of the solar system, as predicted by recent models.
Experimental infection of chickens with Histomonas meleagridis confirms the presence of antibodies in different parts of the intestine

Specific pathogen‐free chickens were infected with a clonal culture of the protozoan parasite, Histomonas meleagridis. Severe lesions were found within the caeca of all birds euthanized at 7 and 14 days post‐infection (d.p.i.). Following necropsy of birds, intestinal samples were taken to establish ex vivo tissue cultures to determine the IgG, IgA and IgM antibody levels in the supernatants before and after incubation with a recently established ELISA. Presence of antibodies was also determined in the sera and first optical density values for IgG above the cut‐off were detected at 14 d.p.i. IgA levels remained low in the serum with a small peak 4 weeks p.i. , a phenomenon also found for IgM. The intestinal tissue samples showed very strong immunological reactions in the parasitized caeca with an initial peak of IgM, high levels of IgG and a continuous increase of IgA. In the duodena and jejuna, IgA values reached similar high levels as those obtained in the caeca, whereas IgG and IgM increased only slightly.
Time Series Segmentation as a Discovery Tool - A Case Study of the US and Japanese Financial Markets

In this paper we explain how the dynamics of a complex system can be understood in terms of the lowdimensional manifolds (phases), described by slowly varying effective variables, it settles onto. We then explain how we can discover these phases by grouping the large number of microscopic time series or time series segments, based on their statistical similarities, into the a small number of time series classes, each representing a distinct phase. We describe a specific recursive scheme for time series segmentation based on the Jensen-Shannon divergence, and check its performance against artificial time series data. We then apply the method on the high-frequency time series data of various US and Japanese financial market indices, where we found that the time series segments can be very naturally grouped into four to six classes, corresponding roughly with economic growth, economic crisis, market correction, and market crash. From a single time series, we can estimate the lifetimes of these macroeconomic phases, and also identify potential triggers for each phase transition. From a cross section of time series, we can further estimate the transition times, and also arrive at an unbiased and detailed picture of how financial markets react to internal or external stimuli.
Methoxyflurane: a review with emphasis on its role in dental practice.

Methoxyflurane was developed as an anaesthetic agent and introduced into clinical practice in 1960. It soon became evident that it possessed analgesic properties that other drugs did not. Due to toxicity concerns, it lost favour in general anaesthesia and had been largely abandoned by the late 1970s. The manufacturer withdrew it in 1999, and the Food and Drug Administration in the United States did not renew its licence in 2005. It has also been withdrawn by the European Union. However, it continues to be used in Australasia, primarily as an inhaled self-administered analgesic by emergency services immediately following trauma. It has become attractive for use in dental practice, likely due to its effectiveness as an analgesic and its additional sedative qualities. Its acceptance is controversial as its use in dentistry is largely elective. Despite its good safety record in analgesic doses, adverse reactions have been recorded. Practitioners should be well aware of risks associated with its use before considering administration, and carefully assess whether or not there are equally good alternative options that do not the carry the same risks. Methoxyflurane is reviewed below with an emphasis on its use in dental practice.
Impact of external flow on the dynamics of swimming microorganisms near surfaces

Swimming microorganisms have been previously observed to accumulate along walls in confined systems both experimentally and in computer simulations. Here, we use computer simulations of dilute populations for a simplified model of an organism to calculate the dynamics of swimmers between two walls with an external fluid flow. Simulations with and without hydrodynamic interactions (HIs) are used to quantify their influence on surface accumulation. We found that the accumulation of organisms at the wall is larger when HIs are included. An external fluid flow orients the organisms parallel to the fluid flow, which reduces the accumulation at the walls. The effect of the flow on the orientations is quantified and compared to previous work on upstream swimming of organisms and alignment of passive rods in flow. In pressure-driven flow, the zero shear rate at the channel center leads to a dip in the concentration of organisms in the center. The curvature of this dip is quantified as a function of the flow rate. The fluid flow also affects the transport of organisms across the channel from one wall to the other.
Rapid PCR Detection of Staphylococcus aureus Clonal Complex 398 by Targeting the Restriction-Modification System Carrying sau1-hsdS1

ABSTRACT A PCR targeting sau1-hsdS1 was developed for rapid detection of Staphylococcus aureus clonal complex 398 (CC398). High sensitivity (100%) and specificity (100%) were shown by evaluating the test on a large strain collection (n = 1,307). We recommend this test for accurate, rapid, and inexpensive diagnosis of methicillin-resistant S. aureus (MRSA) CC398 in hospitals and on farms.
Hermitage Mercahndising and International Marketing

Published by Blackwell Publishing, 9600 Garsington Road, Oxford, OX4 2DQ (UK) and 350 Main Street, Malden, MA 02148 (USA) According to the federal law of the Russian Federation governing charitable foundations and museums, the State Hermitage Museum has exclusive rights to exploit the objects in its collections, the buildings belonging to the museum, the image of the Hermitage itself, and the phrase ‘The Hermitage’. It also has exclusive rights to the reproduction of works from the museum’s collections, the museum’s interiors, the right to exploit scientific research carried out by museum staff, and ownership of all registered trademarks. All the former can be used to promote the museum and its activities. The museum also has the exclusive right to license the manufacture of merchandise based upon the museum’s collections and buildings.
Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G) Published, JLR Papers in Press, January 9, 2009.

Phenolic acids are found in abundance throughout the plant kingdom. Consumption of wine or other rich sources of phenolic acids, such as the “Mediterranean diet,” has been associated with a lower risk of cardiovascular disease. The underlying mechanism(s), however, has remained unclear. Here, we show that many phenolic acids, including those from the hydroxybenzoic and hydroxycinnamic acid classes, can bind and activate GPR109A (HM74a/PUMA-G), the receptor for the antidyslipidemic agent nicotinic acid. In keeping with this activity, treatment with a number of phenolic acids, including cinnamic acid, reduces lipolysis in cultured human adipocytes and in fat pats isolated from wild-type mice but not from mice deficient of GPR109A. Oral administration of cinnamic acid significantly reduces plasma levels of FFA in the wild type but not in mice deficient of GPR109A. Activation of GPR109A by phenolic acids may thus contribute to a cardiovascular benefit of these plant-derived products.
Controlling bubble motion over heated surface through evaporation momentum force to enhance pool boiling heat transfer

Evaporation momentum force arises due to the difference in liquid and vapor densities at an evaporating interface. The resulting rapid interface motion increases the microconvection heat transfer around a nucleating bubble in pool boiling. Microstructure features are developed on the basis of this hypothesis to control the bubble trajectory for (i) enhancing the heat transfer coefficient, and (ii) creating separate liquid and vapor pathways that result in an increased critical heat flux (CHF). An eightfold higher heat transfer coefficient (629 000 W/m2 °C) and two-and-half times higher CHF (3 MW/m2) over a plain copper surface were achieved with water.
Adaptive actuator fault detection, isolation and accommodation in uncertain systems

Adaptive actuator fault detection, isolation, and accommodation problems for linear multi-input single-output (MISO) systems with unknown system parameters are investigated. To solve the detection problem, we construct an adaptive estimate of the output signal. By comparing it with the output of the system, any type of actuator faults can be detected. However, the fault isolation problem is much more complicated. In order to solve it using an adaptive approach, the article considers constant actuator faults, which arise when the actuator output (such as a valve) is stuck at some fixed value. A novel idea which entails controller design for fault isolation is proposed. Thus, the controller in this case is not only designed to meet the control objective, but also to help with fault isolation, in case of an actuator failure. To accomplish this, assuming that there are m inputs, a group of additive functions, called fault isolation design functions in m − 1 inputs, solely used for fault isolation, are introduced. Assuming that less than m − 1 faults can occur, adaptive estimates of the output need to be defined to isolate the faults. Isolation is accomplished by comparing these estimates with the output of the actual system. If there exists only one estimate that matches the output of the system, it is concluded that the combination corresponding to the estimate is the faulty combination. This determines the number of actuator faults and isolates the faulty actuators. Once the faults are detected and isolated, the adaptive fault accommodation problem is accomplished by simply turning off the faulty actuators and using the remaining normal actuators. Finally, an illustrative example with simulation results is provided to support the theoretical results.
[Expression of S100 protein in renal cell carcinoma and its relation with P53].

OBJECTIVE To investigate the expression of S100 in renal cell carcinoma (RCC) and its relation with P53. METHODS Immunohistochemical method was used to detect the expressions of S100A1, S100B and the mutant P53 in 36 RCC and 14 normal kidney tissues. The associations of S100 protein expression with the tumor pathological types, clinical stages and P53 expression were analyzed. RESULTS The positive rates of S100A1 expression in RCC and normal kidney tissues were 72.2% and 21.4%, respectively (P <0.01); S100A1 expression in RCC was significantly correlated with its stage and degree of malignancy. The positive rates of the mutant P53 expression in RCC and normal kidney tissues were 30. 6% and zero respectively (P <0.05), and its expression was not associated with the stage and degree of malignancy degree of RCC (P > 0.05). There was no significant difference in S100B expression between RCC (36.1%) and normal kidney tissues (64.3%, P >0.05). There was no significant correlation between the mutant P53 and S100A1 or S100B expression (P > 0.05). CONCLUSION S100A1 may serve as a new useful marker in judging the degree of malignancy and invasion of RCC.
Durable Goods Sales with Dynamic Arrivals and Changing Valuesy

I study a pro…t-maximizing monopolist selling a durable good to buyers who arrive over time. Buyers are forward looking and their values for the good evolve stochastically. I …rst suppose that the seller commits to a path of posted prices in a stationary environment. Contrary to the case where values remain constant, optimal prices ‡uctuate over time. This is consistent with the use of sales or periodic discounts. If the arrival rate varies with time, the seller favors discounting when the rate is at its fastest, suggesting an explanation for the common empirical …nding of countercyclical markups. A path of posted prices, however, is not the most pro…table mechanism. Because values evolve over time, higher pro…t can be obtained with more sophisticated mechanisms. In particular, the unrestricted optimal mechanism can be implemented by selling options to purchase the good at future dates. As is the case for optimal posted prices, buyers who arrive later expect to earn less rent and expect to wait longer to obtain the good. Contracts agreed at later dates are therefore less e¢ cient. JEL classi…cation: D82. Keywords: changing types, durable goods, dynamic mechanism design, price cycles, sales, countercyclical markups
The photoprotective role of epidermal anthocyanins and surface pubescence in young leaves of grapevine (Vitis vinifera).

BACKGROUND AND AIMS Depending on cultivar, surfaces of young leaves of Vitis vinifera may be glabrous-green ('Soultanina') or transiently have anthocyanins ('Siriki') or pubescence ('Athiri'). A test is made of the hypothesis that anthocyanins and pubescence act as light screens affording a photoprotective advantage to the corresponding leaves, and an assessment is made of the magnitude of their effect. METHODS Measurements were made on young leaves of the three cultivars in spring under field conditions. Photosynthetic gas-exchange and in vivo chlorophyll fluorescence were measured. Photosynthetic and photoprotective pigments were analysed by HPLC. KEY RESULTS Compared with glabrous-green leaves, both anthocyanic and pubescent leaves had greater dark-adapted PSII photochemical efficiency and net photosynthesis. In leaves possessing either anthocyanins or pubescence, the ratio of xanthophyll cycle components to total chlorophyll, and mid-day de-epoxidation state of the xanthophyll cycle were considerably smaller, than in glabrous-green leaves. These differences were more evident in pubescent leaves, probably indicating that trichomes were more effective in decreasing light stress than anthocyanins in the epidermis. CONCLUSIONS Light screens, especially in the form of pubescence, decrease the risk of photoinhibition whilst allowing leaves to maintain a smaller content of xanthophyll cycle components and depend less on xanthophyll cycle energy dissipation. This combination of photoprotective features, i.e. decreased photon flux to the photosynthetic apparatus and lower xanthophyll cycle utilization rates may be particularly advantageous under stressful conditions.
Tricriticality in the q-neighbor Ising model on a partially duplex clique.

We analyze a modified kinetic Ising model, a so-called q-neighbor Ising model, with Metropolis dynamics [Phys. Rev. E 92, 052105 (2015)PLEEE81539-375510.1103/PhysRevE.92. 052105] on a duplex clique and a partially duplex clique. In the q-neighbor Ising model each spin interacts only with q spins randomly chosen from its whole neighborhood. In the case of a duplex clique the change of a spin is allowed only if both levels simultaneously induce this change. Due to the mean-field-like nature of the model we are able to derive the analytic form of transition probabilities and solve the corresponding master equation. The existence of the second level changes dramatically the character of the phase transition. In the case of the monoplex clique, the q-neighbor Ising model exhibits a continuous phase transition for q=3, discontinuous phase transition for q≥4, and for q=1 and q=2 the phase transition is not observed. On the other hand, in the case of the duplex clique continuous phase transitions are observed for all values of q, even for q=1 and q=2. Subsequently we introduce a partially duplex clique, parametrized by r∈[0,1], which allows us to tune the network from monoplex (r=0) to duplex (r=1). Such a generalized topology, in which a fraction r of all nodes appear on both levels, allows us to obtain the critical value of r=r^{*}(q) at which a tricriticality (switch from continuous to discontinuous phase transition) appears.