Miracle-dz/UniFAR-FTUs huggingface dataset:
APPLICATION ACCURACY OF COMPUTED TOMOGRAPHY‐BASED, IMAGE‐GUIDED NAVIGATION OF TEMPORAL BONE

OBJECTIVE Although frameless stereotactic techniques have become indispensable in neurosurgery, their technical complexity requires careful definition and evaluation. Navigation is of particular concern when it is applied to approach a complex, tight surgical area like the temporal bone, where every millimeter is important. Theoretically, the temporal bone is an ideal location in which to use image-guided navigation because its bony construct precludes pre- and intraoperative shift. In this context, the feasibility of using a navigational system is determined by the system's accuracy and by the spatial characteristics of the targets. Literature addressing the accuracy of image guidance techniques in temporal bone surgery is relatively sparse. Accuracy of these systems within the temporal bone is still under investigation. We investigated the application accuracy of computed tomography-based, frameless, image-guided navigation to identify various bony structures in the temporal bone via a retrosigmoid approach. METHODS In a total of 10 operations, we performed a retrosigmoid approach simulating operative conditions on either side of 5 whole, fresh cadaveric heads. Six titanium microscrews were implanted around the planned craniotomy site as permanent bone reference markers before the surgical procedure. High-resolution computed tomographic scans were obtained (slice thickness, 0.6-mm, contiguous non-overlapping slices; gantry setting, 0 degrees; scan window diameter, 225 mm; pixel size, >0.44 × 0.44). We used a Stryker navigation system (Stryker Instruments, Kalamazoo, MI) for intraoperative navigation. External and internal targets were selected for calculation of navigation accuracy. RESULTS The system calculated target registration error to be 0.48 ± 0.21 mm, and the global accuracies (navigation accuracies) were calculated using external over-the-skull and internal targets within the temporal bone. Overall navigation accuracy was 0.91 ± 0.28 mm; for reaching internal targets within temporal bone, accuracy was 0.94 ± 0.22 mm; and for external targets, accuracy was 0.83 ± 0.11 mm. Ninety-five percent of targets could be reached within 1.4 mm of their actual position. CONCLUSION Using high-resolution computed tomography and bone-implanted reference markers, frameless navigation can be as accurate as frame-based stereotaxy in providing a guide to maximize safe surgical approaches to the temporal bone. Although error-free navigation is not possible with the submillimetric accuracy required by direct anatomic contouring of tiny structures within temporal bone, it still provides a road map to maximize safe surgical exposure.
Micrometastasis in the Sentinel Lymph Node of Breast Cancer Does Not Mandate Completion Axillary Dissection

Objective:To determine if micrometastatic disease in the sentinel lymph node is a predictor of non-sentinel lymph node (non-SLN) involvement in breast cancer. Summary Background Data:Sentinel lymph node biopsy (SLN) is an accepted alternative to axillary dissection in staging breast cancer. If the SLN contains metastatic foci, the standard recommendation is completion axillary node dissection (CAD). However, a large subset of patients with metastasis limited to the SLN is unnecessarily subjected to the morbidity of CAD. Methods:A retrospective review of prospectively gathered breast cancer patients having SLN was conducted. Patients with metastasis to the SLN were selected for analysis. Various clinicopathologic features were analyzed for association with metastasis to the non-SLN. Results:A total of 194 women underwent successful SLN dissection. Metastasis to the SLN was found in 48 patients (21 had micrometastases, 27 had macrometastases). Of those with micrometastases, 16 underwent CAD with 1 patient having metastasis to the non-SLN. In patients with macrometastases, 26 had CAD with 14 patients having non-SLN metastasis. Multivariable logistic regression identified only macrometastatic disease in the SLN as significantly associated with involvement of the non-SLN (P = 0.03). None of the patients with micrometastases, including those without CAD, has evidence of local recurrence to date (3–30 months). Conclusion:This study demonstrates that the incidence of non-SLN involvement is low in SLN that contains only micrometastatic foci and is within the accepted range of the false-negative rate of SLN. This suggests that a CAD may be omitted in patients with micrometastatic disease.
Telemetric Intracranial Pressure Monitoring in Blast-Induced Traumatic Brain Injury

The long-term monitoring of intracranial pressure (ICP) is important for the management of acute and chronic neuropathological conditions which include head injury, traumatic brain injury, hydrocephalus, etc. In this study, we developed an implantable device for measuring ICP over long periods of time in an animal model of blast-induced brain injury. The performance of the device was first evaluated in vitro and subsequently utilized to measure ICP in rats exposed to blast overpressures. The effects of blast-induced brain injury on ICP were measured for six days. A significant difference was observed between the injured group and the nonexposed control group. ICP in injured animals showed a biphasic transient increase; an immediate increase within the first 1-3 h and a more gradual elevation occurring two days after the blast. The ability to monitor changes of ICP continuously over long periods after brain injury and during the course of treatment may improve the prognosis after injury and can also serve as a tool in determining the therapeutic effectiveness of new drugs.
Revisiting the Perception of Upside-Down Faces

In two experiments, the effect of orientation on face perception was assessed. Using a scale from 1 (normal) to 7 (bizarre), participants rated normal, unaltered faces and faces in which changes had been made to spatial-relational properties (eyes and mouth inverted or relative position of the eyes and mouth altered) or to component properties (eyes whitened and teeth blackened). For unaltered and component-distortion faces, bizarreness ratings increased linearly as orientation increased from 0° to 180°. For spatial-distortion faces, a discontinuity in the function relating orientation and bizarreness was in evidence between 90° and 120°. The results provide support for the view that there is a qualitative difference in the processing of upright and inverted faces due to the disproportionate effect of inversion on the encoding of spatial-relational information.
Lecithin:Cholesterol Acyltransferase Activation by Sulfhydryl-Reactive Small Molecules: Role of Cysteine-31

Lecithin:cholesterol acyltransferase (LCAT) catalyzes plasma cholesteryl ester formation and is defective in familial lecithin:cholesterol acyltransferase deficiency (FLD), an autosomal recessive disorder characterized by low high-density lipoprotein, anemia, and renal disease. This study aimed to investigate the mechanism by which compound A [3-(5-(ethylthio)-1,3,4-thiadiazol-2-ylthio)pyrazine-2-carbonitrile], a small heterocyclic amine, activates LCAT. The effect of compound A on LCAT was tested in human plasma and with recombinant LCAT. Mass spectrometry and nuclear magnetic resonance were used to determine compound A adduct formation with LCAT. Molecular modeling was performed to gain insight into the effects of compound A on LCAT structure and activity. Compound A increased LCAT activity in a subset (three of nine) of LCAT mutations to levels comparable to FLD heterozygotes. The site-directed mutation LCAT-Cys31Gly prevented activation by compound A. Substitution of Cys31 with charged residues (Glu, Arg, and Lys) decreased LCAT activity, whereas bulky hydrophobic groups (Trp, Leu, Phe, and Met) increased activity up to 3-fold (P < 0.005). Mass spectrometry of a tryptic digestion of LCAT incubated with compound A revealed a +103.017 m/z adduct on Cys31, consistent with the addition of a single hydrophobic cyanopyrazine ring. Molecular modeling identified potential interactions of compound A near Cys31 and structural changes correlating with enhanced activity. Functional groups important for LCAT activation by compound A were identified by testing compound A derivatives. Finally, sulfhydryl-reactive β-lactams were developed as a new class of LCAT activators. In conclusion, compound A activates LCAT, including some FLD mutations, by forming a hydrophobic adduct with Cys31, thus providing a mechanistic rationale for the design of future LCAT activators.
Analysis of power network loading due to fast charging of Electric Vehicles on highways

Limited range of Electric Vehicle's (EV) battery in terms of number of miles per recharge, requires EV to recharge the battery at least once during the long trip. However, long charging durations are not acceptable in these cases, therefore fast charging of EV is needed. Fast charging of EV needs more charging power for relatively shorter period of time, which gives rise to overloading of the power network due to simultaneous charging of multiple EVs at the fast charging stations. This paper studies the power network requirements to meet the EV fast charging needs on highways. Different parameters are considered in the study, for instance, arrival order of EVs at the charging stations, number of charging slots per charging station, power rating of installed chargers, distance between charging stations, state of charge (SoC) of EVs arriving for charging, battery capacities, waiting time at charging stations and the duration of charging. Various scenarios are simulated using Monte Carlo Simulations (MCS) to see the impact of fast charging on the power network loading. The key finding is the peak load on individual fast charging stations with respect to different penetration levels of EVs on the road. A real highway case in Finland is considered in this study to show the rationality of the results.
Evalution of General Anesthesia Using Xylazine-Ketamine Combination with and without Diazipam for Ovariohysterectomy in Bitches

Clinical anesthetic trial was conducted on twelve apparently healthy bitches presented to Gondar University Veterinary Clinic for ovariohysterectomy procedures. The aim of the study is to evaluate the effects of intravenous diazepam on physiological, hematological, and anesthetic parameters and also to assess anesthetic complications and develop anesthetic protocol for dogs. The bitches were randomly assigned into Group I and Group II. Anesthetic protocol was achieved by administration of atropine (0.04 mg/kg BW, S.C) immediately followed with xylazineketamine (1 mg/kg BW+10 mg/kg BW, I.M) for both groups but diazepam (0.5 mg/kg BW, I.V) was also given to Group I bitches when the bitches were attaining lateral recumbency. Physio-hematological and anesthetic parameters were recorded and analyzed. Quality of induction and recovery was statistically significant (P<0.05) difference between the groups. The mean of induction time was significantly (P<0.05) shorter in Group I. The mean time for loss of pedal reflex was found significantly (P<0.05) decreased in group I. Response to surgical incision and muscle relaxation was statistically significant (P<0.05) difference between groups. Duration of anesthesia, time of sternal recumbency, time of unassisted standing and duration of recovery were significantly (P<0.05) longer in Group I as compared Group II. Post anesthetic salivation was significantly (P<0.05) exhibited by Group I. No bitches were died during anesthesia or after recovery. In conclusion, atropine-Xylazine-ketamine-diazepam anesthesia does not affect physio-hematological parameter and is a very satisfactory anesthetic protocol for excellent induction, adequate muscle relaxation, longer duration of anesthesia and smooth recovery compared to atropine-Xylazineketamine anesthesia.
Total Factor Productivity Growth in Chinese Industry: 1952–2005

This paper presents a timely assessment of Chinese industrial productivity performances over the period 1952-2005. The total factor productivity (TFP) growth analysis is based on a Cobb-Douglas specification with aggregated annual data set. This study tackles some theoretical and methodological issues raised by critics of previous studies. First of all, the use of economic tools allows us to relax some restrictive hypothesis of the neoclassical growth framework such as competitive market behaviour, constant returns to scale production technology and Hicks neutral technological change. In addition, our TFP growth estimates are adjusted for business fluctuations. The paper also deals with the autocorrelation issue prevailing in most previous studies. Our major findings are: (i) In Chinese industry, between 1952 and 2005 capital accumulation has been the main engine of economic takeoff. (ii) During the post-reform period, TFP growth contributed significantly to economic growth. (iii) TFP gains have exhibited a sharply increasing pattern since the late 1980’s, along with the accelerated integration of China into the world economy.
The Potential Protective Effects of Calcitonin Involved in Coordinating Chondrocyte Response, Extracellular Matrix, and Subchondral Trabecular Bone in Experimental Osteoarthritis

Previous reports indicate a potential role for calcitonin (CT) in the treatment of osteoarthritis (OA). To evaluate this potential therapeutic role, we investigated the effect of CT pretreatment on the activation of mitogen-activated protein kinase (MAPK) signaling and the expression of matrix metalloproteinase-13 (MMP-13) in interleukin-1β (IL-1β)-induced chondrocytes, and further assessed its protective effect in a rat model of anterior cruciate ligament transection (ACLT), using sham-operated and saline-treated controls. Using western blotting in vitro, we found that CT pretreatment inhibited the IL-1β-induced phosphorylation of 38,000-dalton protein (p38) and extracellular regulated protein 1/2 (ERK1/2) and reduced the expression of MMP-13 protein. For the in vivo experiment, 30 male rats were randomly divided into three groups of 10, subjected to bilateral ACLT or sham surgery, and then treated for 12 weeks with subcutaneous injections of CT or normal saline. Histological observations showed that CT treatment reduced the severity of the cartilage lesions stemming from the ACLT surgery and provided a lower Mankin score when compared with that determined for rats in the saline-treated ACLT group. Immunohistochemical staining revealed that CT treatment increased type II collagen expression and decreased MMP-3 and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) expression when compared with the saline-treated group. Subchondral bone analysis indicated that CT treatment inhibited the reduction in bone mineral density observed in the saline-treated ACLT group and reduced the ACLT-induced destruction to the subchondral trabecular microstructure. Our data demonstrate that CT induces its protective effects by reducing the chondrocyte response to inflammatory stimuli, cartilage extracellular matrix degradation, and subchondral trabecular microstructure damages brought on by OA.
Large-Eddy Simulations of Radiatively Driven Convection: Sensitivities to the Representation of Small Scales

Abstract Large-eddy simulations of a smoke cloud are examined with respect to their sensitivity to small scales as manifest in either the grid spacing or the subgrid-scale (SGS) model. Calculations based on a Smagorinsky SGS model are found to be more sensitive to the effective resolution of the simulation than are calculations based on the prognostic turbulent kinetic energy (TKE) SGS model. The difference between calculations based on the two SGS models is attributed to the advective transport, diffusive transport, and/or time-rate-of-change terms in the TKE equation. These terms are found to be leading order in the entrainment zone and allow the SGS TKE to behave in a way that tends to compensate for changes that result in larger or smaller resolved scale entrainment fluxes. This compensating behavior of the SGS TKE model is attributed to the fact that changes that reduce the resolved entrainment flux (viz., values of the eddy viscosity in the upper part of the PBL) simultaneously tend to increase the .
[The effect of group exercise on postmenopausal osteoporosis and osteopenia].

OBJECTIVES We investigated the effects of group exercise on bone mineral density (BMD), pain, and quality of life in postmenopausal women with osteoporosis and osteopenia. METHODS The study included 16 osteoporotic (mean age 55.2 years) and 17 osteopenic (mean age 55.4 years) postmenopausal women whose diagnoses were made by dual energy X-ray absorptiometry (DEXA) showing T-scores of less than -2.5 and in a range of -1 to -2.5, respectively. Subjects having orthopedic, neurological, respiratory, vascular, metabolic, or mental problems were excluded. Each group received the same group exercise program for one hour three times a week for 21 weeks, supervised by a physiotherapist, and including breathing, warm-up, stretching, strengthening, balance, stabilization, and cooling exercises. All participants were evaluated before and after the exercise program by a visual analog scale for pain severity, by DEXA for BMD, and by QUALEFFO-41 (Quality of Life Questionnaire of the European Foundation for Osteoporosis) for quality of life. RESULTS The two groups were similar with respect to age, height, and body mass index (p>0.05), but osteopenic women had a higher body weight (p<0.05). After the exercise program, both groups exhibited significant improvements in T-score, pain score, BMD, and all parameters of the QUALEFFO-41 (p<0.05). The mean T-scores before and after exercise were -2.7 + or - 0.2 and -2.4 + or - 0.5 in osteoporotic women, and -1.8 + or - 0.5 and -1.4 + or - 0.5 in osteopenic women, respectively. Following exercise, 43.8% of osteoporotic women had a T-score showing osteopenia, and 23.5% of osteopenic women had a T-score falling within the normal range. The two groups did not differ significantly with respect to the differences between the mean improvements obtained after the exercise program (p>0.05). CONCLUSION This pilot study demonstrates the effectiveness of physiotherapist-supervised group exercise programs in decreasing pain and increasing BMD and quality of life of both osteoporotic and osteopenic women.
Physiological identification of the human pedunculopontine nucleus

Background: The pedunculopontine nucleus (PPN) is a brainstem structure with widespread connections to the basal ganglia. Despite the recent introduction of PPN deep brain stimulation (DBS) for the treatment of gait disorders, little is known about its physiology in humans. Methods: Single unit discharge characteristics of neurons in the PPN region were analysed in four patients and PPN local field potentials (LFP) in one patient, recorded during the course of DBS implantation. Two patients had Parkinson disease, and two had non-sinemet responsive parkinsonism. Cell locations were plotted in the coordinate system of a human brainstem atlas. Results: Fifty-six units in the PPN region were studied, of which 32 mapped to within PPN boundaries. The mean (SD) discharge rate of neurons in the PPN was 23.2 (15.6) Hz. Spontaneous neuronal firing rate and burst discharge rate were significantly different between neurons in the region dorsal to PPN and those in the PPN. Responses to passive movement of contralateral and ipsilateral limbs were found. Theta and beta band oscillations were present in the PPN LFP. Conclusion: PPN discharge characteristics may prove useful in the electrophysiological identification of PPN during DBS implantation surgery.
Malnutrition affects quality of life in gastroenterology patients.

AIM To investigate the association between malnutrition and quality of life in patients with benign gastrointestinal disease. METHODS Two hundred patients (104 wellnourished and 96 malnourished) were assessed according to the Subjective Global Assessment, anthropometric measurements and bioelectrical impedance analysis. Quality of life was determined with the validated Medical Outcomes Study 36-item Short-Form General Health Survey (SF 36). Muscle function was assessed by hand grip strength and peak flow. RESULTS Body mass index, body cell mass, arm muscle area and hand grip strength were significantly lower in the malnourished patients. Quality of life was generally lower when compared to norm values. Seven out of eight quality of life scales (excluding bodily pain) were significantly reduced in the malnourished patients. Comparing patients with liver cirrhosis and inflammatory bowel disease (IBD), patients with IBD experienced significantly lower values in the perception of bodily pain,social functioning and mental health. Malnourished liver cirrhotics suffered reductions in more scales (six out of eight) than malnourished IBD patients did (four out of eight). CONCLUSION Quality of life is generally low in benign gastrointestinal disease and is further reduced in patients who are classified as malnourished. It appears that liver cirrhosis patients experience a higher quality of life than IBD patients do, but the impact of malnutrition seems to be greater in liver cirrhosis than in IBD.
Body composition in normal subjects: relation to lipid and glucose variables.

OBJECTIVE To describe sex- and age-dependent values of total and regional body composition as determined by dual-energy X-ray absorptiometry (DXA) in normal subjects, and furthermore to relate body composition measurements to blood lipids, glucose and insulin concentrations. DESIGN A cross-sectional study. SUBJECTS 173 (84 male and 89 female) healthy subjects, BMI < 30 kg/m2. MEASUREMENTS Body composition parameters including data on total bone mineral content (TBMC), total bone mineral density (TBMD), lean body soft tissue mass (LTM), total and regional fat mass (FM) were estimated in all subjects. In 87 of the subjects fasting blood glucose, S-insulin and lipid profile were measured. RESULTS The study population was for each sex divided into five decades for which results on body composition and blood lipids are presented. Body weight increased 2 kg per age decade, representing a significant increase in both total FM and relative FM (FM%BW) with age, and in males a central accumulation of FM. LTM decreased significantly in males but not in females, whereas TBMC and TBMD remained constant in males, but decreased in females. A significant correlation between relative FM and S-cholesterol, S-triglyceride, and in males S-insulin was found. CONCLUSION The present study gives coherent data on bone mineral content, lean body soft tissue mass total and regional fat mass for 173 healthy subjects with a BMI below 30 kg/m2. Total body fat mass increases, and lean mass decreases with age. In males a simultaneous central accumulation of fat mass is observed. The well-known relationship between central obesity and lipids is confirmed even in non-obese subjects.
VLSI considerations for TESH: a new hierarchical interconnection network for 3-D integration

This paper discusses very large scale integration (VLSI) issues, including reconfiguration and yield, for a new interconnection network, "Tori connected mESHes (TESH)". Its key features are the following: (1) it is hierarchical, thus allowing exploitation of computation locality as well as easy expansion up to a million processors, (2) it permits efficient VLSI/ULSI (ultralarge scale integration) realization, and (3) it appears to be well suited for three-dimensional (3-D) implementation. This is due in part to the fact that it requires far fewer number of vertical wires than most other multicomputer networks of comparable diameter, as demonstrated by a 4096 node example. Presented in the paper are the architecture of the new network, node addressing and message routing, VLSI considerations, and most importantly, the reconfiguration and yield studies.