Miracle-dz/UniFAR-FTUs huggingface dataset:
Circadian Blood Pressure Rhythm Is Disturbed by Nephrectomy

We recently illustrated a close relationship between glomerular filtration rate and circadian rhythm of blood pressure (BP) in patients with chronic kidney disease. However, it remains undetermined from such cross-sectional findings which occurs first, the loss of kidney function or the lack of nocturnal BP fall. In the present study, we examined whether circadian rhythm of BP is affected by unilateral nephrectomy for kidney donation to clarify this important issue. Fifteen healthy subjects (4 men, 11 women; aged 33 to 65 years; mean age 55±2 years) who underwent unilateral nephrectomy for kidney donation were studied. Ambulatory BP was monitored for 24 h, while serum and urinary samples were collected to estimate creatinine clearance before and on the 8th day after nephrectomy. Then, changes in the night/day ratios of mean arterial BP were analyzed in relation to the decrease in 24-h creatinine clearance as a marker of glomerular filtration rate by nephrectomy. Creatinine clearance was reduced by 29% in average from 84±6 to 60±4 ml/min by nephrectomy, while 24-h mean arterial BP values were 91±3 and 94±4 mmHg (p=0.08) before and after nephrectomy. Although mean BP (daytime, nighttime or night/day ratio) was not altered significantly by nephrectomy, the decrease in creatinine clearance was positively correlated with the increase in the night/day ratio of mean BP (r=0.61, p=0.017). The decrease in creatinine clearance was not correlated with changes in either 24-h, daytime or nighttime mean BP. Our results suggest that unilateral nephrectomy disturbs the circadian rhythm of BP as a function of renal dysfunction without affecting absolute levels of BP. Non-dipping of BP seems the consequence of the loss of renal function, rather than the cause.
Midterm Results of Endovascular Infrarenal Abdominal Aortic Aneurysm Repair in High-Risk Patients

Short-term and midterm clinical outcomes after endovascular repair of abdominal aortic aneurysms (AAAs) have been well documented. Evaluation of longer term outcomes is now possible. Here we describe our initial 100 high-risk patients treated with endovascular aneurysm repair (EVAR), all with a minimum of 5 years of follow-up. A retrospective review of prospectively recorded data in a departmental database was undertaken for the first 100 consecutive EVAR patients with a minimum of 5 years (range, 60-105 months) of follow-up performed between December 1997 and June 2001. Information was obtained from surgical follow-up visits and family doctors' offices. Endovascular repair of AAA in high-risk patients can be achieved with acceptably low postoperative mortality and morbidity. Longer term results in this high-risk cohort suggest that EVAR is effective in preventing aneurysm-related deaths at 5 years and beyond. All late mortalities were due to patients' comorbid diseases.
N-methyl carbamate concentrations and dietary intake estimates for apple and grape juices available on the retail market in Canada

Infants and young children consume fruit juices and drinks at rates exceeding those of older children and adults. Carbamate pesticides are known to be used on a broad spectrum of crops, including orchard and vine crops such as apples and grapes. Concern over potential exposure to these acutely toxic pesticides by infants and young children has increased in the last decade. Liquid chromatography with fluorescence detection was used to determine the concentrations of seven N-methyl carbamates and three transformation products in domestic and imported apple and grape juices collected across Canada. Carbaryl was the most frequently (58.6%) detected N-methyl carbamate in juice samples studied. It was observed more frequently in grape juices than in apple or mixed juices. Oxamyl and methomyl were detected in apple juice samples, although they were below detection limits in all grape and mixed juice samples analysed. Maximum levels of carbaryl, methomyl and oxamyl were 93, 6.7 and 4.6 ng ml–1, respectively. All other analytes were not present in any juice sample at concentrations above the method detection limit (0.3 ng ml–1). In all cases, N-methyl carbamate residues were well below the maximum residue limit established for apples and grapes in the Canadian Food and Drug Regulations. No estimated dietary intakes were above the acceptable daily intakes in any age–sex category, where an acceptable daily intake has been proposed. Carbaryl short-term intake estimates were calculated and all were below the proposed acute reference doses.
Rituximab and chemotherapy in primary gastric lymphoma.

PURPOSE We performed a phase II clinical trial to assess the efficacy and toxicity of the addition of rituximab and conventional chemotherapy in primary gastric lymphoma (PGL). METHODS Forty-two (42) patients with PGL, stage IE and IIE, and with low- or low-intermediate clinical risk were treated in a prospective longitudinal study with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy and rituximab (375 mg/m2, intravenously) on day 1 of each cycle administered every 21 days, for 6 cycles. The endpoint was to assess improvement in outcome measured by prolongation in event-free survival (EFS) and overall survival (OS). Complete response was achieved in 40 cases (95%) (95% confidence interval [CI]: 88%-102%). Relapse was observed in 2 cases. Two (2) patients died secondary to tumor progression. Thus, actuarial 5-year EFS was 95% (95 % CI: 87%-104%) and OS was 95% (95% CI: 88%-101%), which was not statistically different to historic controls. Acute toxicity was minimal and well tolerated, 4 cases developed late toxicity, 2 cases of herpes zoster infection, and 2 cases with granulocytopenia; in 1 case, the patient continued with mild granulocytopenia 3 years after treatment. CONCLUSIONS The addition of rituximab to CHOP chemotherapy did not improve outcome in early-stage PGL.
Expression of S100A4, E-cadherin, alpha- and beta-catenin in gastric adenocarcinoma.

BACKGROUND/AIMS This investigation aimed to elucidate the expression patterns of S100A4 and adhesion molecules in gastric carcinoma and to estimate their correlation with clinicopathologic parameters. METHODOLOGY The expression of S100A4, E-cadherin, alpha- and beta-catenin was studied in 251 gastric carcinoma specimens through immunohistochemical staining. RESULTS The positive expression of S100A4 was significantly associated with advanced gastric cancer, higher pTNM stage, and poorer survival rates, especially when present in nuclear staining. The reduced expression of adhesion molecules was significantly associated with diffuse type of gastric cancer. The reduced expression of beta-catenin was significantly associated with lymph node metastasis, especially in early gastric cancer. The coexpression status of S100A4-positive and reduced beta-catenin was significantly associated with larger tumor size, advanced tumor depth, and higher pTNM stage. CONCLUSIONS S100A4 and adhesion molecule expression may be a useful prognostic marker for individual gastric cancer patients.
Prenatal Exposure to Persistent Organochlorines and Childhood Obesity in the U.S. Collaborative Perinatal Project

Background: In some previous studies, prenatal exposure to persistent organochlorines such as 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p´-DDE), polychlorinated biphenyls (PCBs), and hexachlorobenzene (HCB) has been associated with higher body mass index (BMI) in children. Objective: Our goal was to evaluate the association of maternal serum levels of β-hexachlorocyclohexane (β-HCH), p,p´-DDE, dichlorodiphenyltrichloroethane (p,p´-DDT), dieldrin, heptachlor epoxide, HCB, trans-nonachlor, oxychlordane, and PCBs with offspring obesity during childhood. Methods: The analysis was based on a subsample of 1,915 children followed until 7 years of age as part of the U.S. Collaborative Perinatal Project (CPP). The CPP enrolled pregnant women in 1959–1965; exposure levels were measured in third-trimester maternal serum that was collected before these organochlorines were banned in the United States. Childhood overweight and obesity were defined using age- and sex-specific cut points for BMI as recommended by the International Obesity Task Force. Results: Adjusted results did not show clear evidence for an association between organochlorine exposure and obesity; however, a suggestive finding emerged for dieldrin. Compared with those in the lowest quintile (dieldrin, < 0.57 μg/L), odds of obesity were 3.6 (95% CI: 1.3, 10.5) for the fourth and 2.3 (95% CI: 0.8, 7.1) for the highest quintile. Overweight and BMI were unrelated to organochlorine exposure. Conclusions: In this population with relatively high levels of exposure to organochlorines, no clear associations with obesity or BMI emerged. Citation: Cupul-Uicab LA, Klebanoff MA, Brock JW, Longnecker MP. 2013. Prenatal exposure to persistent organochlorines and childhood obesity in the U.S. Collaborative Perinatal Project. Environ Health Perspect 121:1103–1109; http://dx.doi. org/10.1289/ehp.1205901
Identification and functional characterization of Epstein-Barr virus DNA polymerase by in vitro transcription-translation of a cloned gene

In order to identify the gene encoding the Epstein-Barr virus (EBV) DNA polymerase, a portion of the BamHI-A fragment containing the fifth leftward open reading frame (BALF5) of the EBV genome was cloned into SP6 and T7 promoter-containing vectors for in vitro transcription-translation. The RNA synthesized in vitro was used to program rabbit reticulocyte lysates, which were analyzed for the synthesis of the putative polymerase polypeptide (110 kDa) and assayed directly for EBV DNA polymerase activity. The polypeptide synthesized by the full-length BALF5 genomic fragment had a molecular mass of 110 kDa. 5'-truncated BALF5 with the first and second ATGs deleted produced 95- and 83-kDa polypeptides, respectively. All three translation products were enzymatically active and displayed resistance to high salt concentrations. The identity of the largest polypeptide as the viral polymerase was established by (i) immunoprecipitation with EBV-positive sera from patients with nasopharyngeal carcinoma and by a rabbit polyclonal antiserum prepared with a synthetic peptide derived from the DNA sequence of BALF5; (ii) identification of a polypeptide of identical size (110 kDa) immunoprecipitated from superinfected Raji cell extracts by these antibodies; and (iii) salt-resistant enzymatic activity which was neutralized by the rabbit EBV antiserum. Thus, BALF5 encodes a functional polymerase identical to that induced in superinfected Raji cells.
A Vicious Cycle

Can social–psychological theory provide insight into the extreme racial disparities in school disciplinary action in the United States? Disciplinary problems carry enormous consequences for the quality of students’ experience in school, opportunities to learn, and ultimate life outcomes. This burden falls disproportionately on students of color. Integrating research on stereotyping and on stigma, we theorized that bias and apprehension about bias can build on one another in school settings in a vicious cycle that undermines teacher–student relationships over time and exacerbates inequality. This approach is more comprehensive than accounts in which the predicaments of either teachers or students are considered alone rather than in tandem, it complements nonpsychological approaches, and it gives rise to novel implications for policy and intervention. It also extends prior research on bias and stigmatization to provide a model for understanding the social–psychological bases of inequality more generally.
Mixed mode of charge transfer to ground for initial continuous current pulses in upward lightning

In this paper, we discuss properties of initial continuous current (ICC) pulses superimposed on the slow varying initial stage current in upward flashes initiated from the Gaisberg Tower (GBT) based on simultaneous current, near/far electric field measurements. ICC pulses are usually associated with M-component mode of charge transfer to ground, if only one branch of the lightning channel is active. However, there are several cases in which ICC pulses involve a predominantly leader/return-stroke mode of charge transfer to ground in a new channel that connects to the old channel carrying continuous current. With the help of high-speed video camera records, we find that this mixed mode of charge transfer for ICC pulses, leader-return stroke in one channel and continuous current in another channel, occurring simultaneously during the initial stage current in upward lightning from tall towers is very common. This is in contrast to triggered-lightning where usually only one channel is dominant and ICC pulses are associated predominantly with M-component mode of charge transfer. Also, ICC pulses with mixed-mode of charge transfer have shorter risetimes, larger peaks, and shorter half-peak widths.
Adapting data collection methods in the Australian Life Histories and Health Survey: a retrospective life course study

Objective Ideally, life course data are collected prospectively through an ongoing longitudinal study. We report adaptive multimethod fieldwork procedures that gathered life history data by mail survey and telephone interview, comparable with the face-to-face methods employed in the English Longitudinal Study on Ageing (ELSA). Design The Australian Life Histories and Health (LHH) Survey was a substudy of the Australian 45 and Up Study, with data collection methods modified from the ELSA Study. A self-complete questionnaire and life history calendar were completed by the participants, followed by a computer-assisted telephone interview recording key life events. Results The LHH survey developed and tested procedures and instruments that gathered rich life history data within an ongoing Australian longitudinal survey on ageing. Data collection proved to be economical. The use of a self-complete questionnaire in conjunction with a life history calendar and coordinated computer-assisted telephone interview was successful in collecting retrospective life course information, in terms of being thorough, practical and efficient. This study has a diverse collection of data covering the life course, starting with early life experiences and continuing with socioeconomic and health exposures and outcomes during adult life. Conclusions Mail and telephone methodology can accurately and economically add a life history dimension to an ongoing longitudinal survey. The method is particularly valuable for surveying widely dispersed populations. The results will facilitate understanding of the social determinants of health by gathering data on earlier life exposures as well as comparative data across geographical and societal contexts.
Habitability of waterworlds: runaway greenhouses, atmospheric expansion, and multiple climate states of pure water atmospheres.

There are four different stable climate states for pure water atmospheres, as might exist on so-called "waterworlds. " I map these as a function of solar constant for planets ranging in size from Mars-sized to 10 Earth-mass. The states are as follows: globally ice covered (Ts ⪅ 245 K), cold and damp (270 ⪅ Ts ⪅ 290 K), hot and moist (350 ⪅ Ts ⪅ 550 K), and very hot and dry (Tsx2A86;900 K). No stable climate exists for 290 ⪅ T s ⪅ 350 K or 550 ⪅ Ts ⪅ 900 K. The union of hot moist and cold damp climates describes the liquid water habitable zone, the width and location of which depends on planet mass. At each solar constant, two or three different climate states are stable. This is a consequence of strong nonlinearities in both thermal emission and the net absorption of sunlight. Across the range of planet sizes, I account for the atmospheres expanding to high altitudes as they warm. The emitting and absorbing surfaces (optical depth of unity) move to high altitude, making their area larger than the planet surface, so more thermal radiation is emitted and more sunlight absorbed (the former dominates). The atmospheres of small planets expand more due to weaker gravity; the effective runaway greenhouse threshold is about 35 W m(-2) higher for Mars, 10 W m(-2) higher for Earth or Venus, but only a few W m(-2) higher for a 10 Earth-mass planet. There is an underlying (expansion-neglected) trend of increasing runaway greenhouse threshold with planetary size (40 W m(-2) higher for a 10 Earth-mass planet than for Mars). Summing these opposing trends means that Venus-sized (or slightly smaller) planets are most susceptible to a runaway greenhouse. The habitable zone for pure water atmospheres is very narrow, with an insolation range of 0.07 times the solar constant. A wider habitable zone requires background gas and greenhouse gas: N2 and CO2 on Earth, which are biologically controlled. Thus, habitability depends on inhabitance.
The mitogenome of Liobagrus marginatoides (Teleostei, Siluriformes:Amblycipitidae)

Liobagrus marginatoides is endemic to southwest China (Ding, 1994), according to morphological taxonomy, and it is very similar to Liobagrus nigricauda, but its population is much smaller. In this study, the complete mitochondrial genome sequence of L. Marginatoides has been obtained with polymerase chain reaction (PCR), which contains 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and a non-coding control region with the total length of 16,498 bp. The gene arrangement and composition are similar to that of other vertebrates. Most of the genes are encoded on heavy strand, except for eight tRNA and ND6 genes. Just like most other vertebrates, the against bias of G has a universality in different statistics results. The complete mitochondrial genome sequence of L. Marginatoides would contribute to better understand population genetics and protect its genetic diversity.
Measurement of blood‐brain barrier permeability in a tumor model using magnetic resonance imaging with gadolinium‐dtpa

Sequential MR imaging with gadolinium‐diethylenetriaminepentaacetic acid (Gd‐DTPA) and sequential measurements of plasma Gd‐DTPA concentration by inductively coupled plasma atomic emission spectroscopy (ICP‐AES) were used to estimate the blood‐to‐tissue transport coefficient (Ki) in the 36B‐10 rat glioma model. For these measurements, tissue Gd‐DTPA concentration was estimated from tumor enhancement by correlation with calibration measurements obtained by ICP‐AES analysis of tumor tissue. The 14 animals for which Ki, was calculated can be grouped into those imaged at 11 days following tumor implantation, at 13‐18 days, and at 20 days. The mean (+SEM) Ki values for these groups were 1.1 + 0.24, 9.2 + 0.8, and 13.4 + 1.7 ml/kg‐min, respectively. These results correspond well with published data obtained by quantitative autoradiography. It is concluded that frequent sequential imaging and a graphical approach to Ki, calculation are promising methods for determining the blood‐to‐tissue transport coefficient noninvasively by contrastenhanced MRI.
Asymmetric Meckel Cave Enlargement: A Potential Marker of PHACES Syndrome

BACKGROUND AND PURPOSE: PHACES syndrome is a complex of morphologic abnormalities of unknown cause and includes posterior fossa abnormalities; head and neck infantile hemangiomas; arterial, cardiac, and eye anomalies; and sternal or abdominal wall defects. Accurate identification of the syndrome is important for optimal treatment. The purpose of this study was to investigate the incidence of asymmetric Meckel cave enlargement, a potential novel imaging marker, in a population of patients referred for evaluation of possible PHACES syndrome. MATERIALS AND METHODS: Eighty-five patients referred for neuroimaging evaluation of possible PHACES syndrome were identified and stratified on the basis of their ultimate clinical PHACES diagnosis categorization into PHACES, possible PHACES, or not PHACES. MR imaging studies were subsequently reviewed for the presence or absence of unilateral Meckel cave enlargement, with the reviewer blinded to the ultimate PHACES syndrome categorization. RESULTS: Twenty-five of 85 patients (29%) were ultimately categorized as having PHACES or possible PHACES according to consensus guidelines. Asymmetric Meckel cave enlargement was present in 76% (19/25) of these patients and in 82% (19/23) of only those patients with definite PHACES. This finding was present in none of the 60 patients determined not to have PHACES syndrome. In 7/19 patients (37%) with this finding, subtle MR imaging abnormalities consistent with PHACES were missed on the initial MR imaging interpretation. CONCLUSIONS: Asymmetric Meckel cave enlargement was a common feature of patients with PHACES in our cohort and may serve as a novel imaging marker. Increased awareness of this imaging feature has the potential to increase the diagnostic accuracy of PHACES.
Iron-Chelating Activity of Tetracyclines and Its Impact on the Susceptibility of Actinobacillus actinomycetemcomitansto These Antibiotics

ABSTRACT Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possess iron-chelating activity in a colorimetric siderophore assay. Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other hand, the MICs of doxycycline and minocycline were significantly lower for A. actinomycetemcomitans cultivated under iron-poor conditions than under iron-rich conditions.
Patency of the Anterior Choroidal Artery after Flow-Diversion Treatment of Internal Carotid Artery Aneurysms

BACKGROUND AND PURPOSE: Treatment of cerebral aneurysms with flow diverters often mandates placement of the device across the ostia of major branches of the internal carotid artery. We determined the patency rates of the anterior choroidal artery after placement of flow-diversion devices across its ostium. MATERIALS AND METHODS: We analyzed a consecutive series of patients in whom a Pipeline Embolization Device was placed across the ostium of an angiographically visible anterior choroidal artery while treating the target aneurysm. Patency of the anterior choroidal artery after Pipeline Embolization Device placement was determined at immediate postoperative and follow-up angiography. Data on pretreatment aneurysm rupture status, concomitant coiling, number of Pipeline Embolization Devices used, neurologic status at follow-up, and follow-up MR imaging/CT findings were collected. RESULTS: Fifteen patients with 15 treated aneurysms were included in this study. In the immediate postprocedural setting, the anterior choroidal artery was patent on posttreatment angiography for all 15 patients. Of the 14 patients with follow-up angiography at least 6 months after Pipeline Embolization Device placement, 1 (7%) had occlusion of the anterior choroidal artery and 14 had a patent anterior choroidal artery (93%). No patients had new neurologic symptoms or stroke related to anterior choroidal artery occlusion at follow-up. Of the 9 patients with follow-up CT or MR imaging, none had infarction in the vascular territory of the anterior choroidal artery. CONCLUSIONS: In this small study, placement of a Pipeline Embolization Device across the anterior choroidal artery ostium resulted in occlusion of the artery in only 1 patient. It was not associated with ischemic changes in the distribution of the anterior choroidal artery in any patient.