Miracle-dz/UniFAR-FTUs huggingface dataset:
Ca 2-Myristoyl Switch in the Neuronal Calcium Sensor Recoverin Requires Different Functions of Ca 2-binding Sites *

Recoverin is an EF-hand Ca -binding protein that is suggested to control the activity of the G-protein-coupled receptor kinase GRK-1 or rhodopsin kinase in a Ca -dependent manner. It undergoes a Ca -myristoyl switch when Ca binds to EF-hand 2 and 3. We investigated the mechanism of this switch by the use of point mutations in EF-hand 2 (E85Q) and 3 (E121Q) that impair their Ca binding. EF-hand 2 and 3 display different properties and serve different functions. Binding of Ca to recoverin is a sequential process, wherein EFhand 3 is occupied first followed by the filling of EFhand 2. After EF-hand 3 bound Ca , the subsequent filling of EF-hand 2 triggers the exposition of the myristoyl group and in turn binding of recoverin to membranes. In addition, EF-hand 2 controls the mean residence time of recoverin at membranes by decreasing the dissociation rate of recoverin from membranes by 10fold. We discuss this mechanism as one critical step for inhibition of rhodopsin kinase by recoverin.
Customer perception mapping analysis of Indonesian e-commerce marketplace sites based on attributes usability, site design, information quality, trust, and empathy (Case study of Tokopedia, Bukalapak, Elevenia, Qoo10, and Rakuten)

Online shopping through social media becomes popular in Indonesia. It was a challenge for e-commerce sites, especially online marketplace, which is in the last five years present in the e-commerce industry in Indonesia. In order to gain customer attention, e-commerce marketplace sites in Indonesia spent billions of rupiah for advertising expenditure in television. However, the key challenge for e-commerce company is how to develop their web site presence to match the customer perception, which, through the web site, direct customer interaction occurs. Customer perception was very important because it affects actual customer behavior. The objective of this research was to map customer perception of e-commerce marketplace in Indonesia based on the similarity of each marketplace site and attributes usability, site design, information quality, trust and empathy as the core qualities of Webqual 4.0. In total, 385 usable questionnaires were obtained from respondents across Indonesia through online survey. Multidimensional Scaling (MDS) was employed for data analysis. Data were collected during January to early February 2016. Based on the results, Tokopedia and Bukalapak were the most ideal e-commerce marketplace perceived by customers, as well as the two most competitive companies, followed by Elevenia, Qoo10, and Rakuten. This result suggested to improve the quality of the online marketplace website to match customer perceptions. The companies should evaluate and improve their quality of theirs website which consist of attributes usability, site design, information quality, trust, and empathy.
The analysis of information technology best practice adoption in Saudi Arabia

i ACKNOWLEDGEMENT . iii TABLE OF CONTENTS . v LIST OF TABLES . xi LIST OF FIGURES . xii GLOSSARY . xiii CHAPTER 1INTRODUCTION . 1 1.1 Research Background . 1 1.2 Research Objectives and Questions . 2 1.3 Rationale for the Study . 3 1.4 Importance of the Current Research . 3 1.5 Thesis Structure . 5 CHAPTER 2:LITERATURE REVIEW OF ITIL IMPLEMENTATION CSFs. 7 2.
Multiple Contact Network Is a Key Determinant to Protein Folding Rates

Understanding the relationship between amino acid sequences and folding rates of proteins is an important task in computational and molecular biology. It has been shown that topological parameters, contact order, long-range order, and total contact distance relate well with protein folding rates. In this work, we have systematically analyzed the influence of amino acid residues that form multiple contacts in protein structures to folding rates of proteins. We observed an inverse relationship between the number of residues with multiple contacts and protein folding rates. Further analysis indicates that multiple contacts are influenced by hydrophobic residues, whereas the role is minimal between the residues that are capable of forming hydrogen bonds. The propensity of multiple contacts forming residues showed that aromatic and hydrophobic residues are dominant in two-state proteins, whereas the polar residues Ser and Thr are also preferred ones in three-state proteins. In addition, multiple contact forming residues are interconnected with each other through contact networks in protein structures. The comparison between slow and fast folding proteins demonstrated the presence of more multiple contact forming residues in slow folding proteins with a limit of 4-6 contacts/residue. These results have been reflected in amino acid sequences in the form of short-, medium-, and long-range contacts, which could discriminate slow and fast folding proteins with an accuracy of 96% using a 5-fold cross-validation method.
Financial literacy and household investment choices in Uganda.

This study, aims at investigating the relationship between financial literacy and household investment choices. Specifically, the study establishes whether households with high financial literacy levels are more likely to choose to invest; through a bank investment account, with an informal group, in a personal business or invest in Agriculture. Financial literacy is measured using three questions that capture an understanding of the basic financial concepts of interest rate, discounting and borrowing. Both bivariate and multivariate analysis techniques and a Probit model are used to tease out the levels of financial literacy, its determinants and its relationship with household investment choices. The study results reveal low levels of financial literacy in Uganda. Also, the study reveals that financial literacy is significantly associated with household socio-demographic factors. The study finds that, financial literacy is positively and significantly associated with household investment choices. The study establishes a key investment venture of Agriculture which requires to be revamped since it is neglected yet it is still very essential to the country’s economy. The results also contribute to the government’s National Financial Literacy Strategy by establishing the population segments that is most/least financially literate hence such initiatives should be directed towards such population groups with low financial literacy levels.
Smad3: A Key Player in Pathogenetic Mechanisms Dependent on TGF‐β

Abstract: Transforming growth factor‐β (TGF‐β), a key player in a large variety of physiological and disease processes, signals through transmembrane receptor serine/threonine kinases to activate novel signaling intermediates called Smad proteins, which then modulate transcription of target genes. We have utilized mice with a targeted deletion of Smad3, one of two homologous proteins involved in signaling from TGF‐β/activin, to investigate the function of this particular pathway in transducing such effects of TGF‐β. The dramatic results of the absence of Smad3 on parameters of healing of cutaneous wounds, such as reepithelialization and influx of inflammatory cells, as well as on fibrosis as modeled by radiation fibrosis of skin in mice, suggest that signaling flux through Smad3 is critical for chemotactic activity of TGF‐β, inhibitory effects of TGF‐β on keratinocyte proliferation and migration, and chemoattraction and elaboration of extracellular matrix by fibroblasts in fibrotic diseases. We recently identified a novel molecule, TLP for TRAP‐1‐like protein, which selectively interferes with Smad3 signaling, and are currently investigating whether levels of this protein might be altered in disease to change the relative flow of information from Smad2 and Smad3.
Risk Factors for Acute Myocardial Infarction in Latin America: The INTERHEART Latin American Study

Background— Current knowledge of the impact of cardiovascular risk factors in Latin America is limited. Methods and Results— As part of the INTERHEART study, 1237 cases of first acute myocardial infarction and 1888 age-, sex-, and center-matched controls were enrolled from Argentina, Brazil, Colombia, Chile, Guatemala, and Mexico. History of smoking, hypertension, diabetes mellitus, diet, physical activity, alcohol consumption, psychosocial factors, anthropometry, and blood pressure were recorded. Nonfasting blood samples were analyzed for apolipoproteins A-1 and B-100. Logistic regression was used to estimate multivariate adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). Persistent psychosocial stress (OR, 2.81; 95% CI, 2.07 to 3.82), history of hypertension (OR, 2.81; 95% CI, 2.39 to 3.31), diabetes mellitus (OR, 2.59; 95% CI, 2.09 to 3.22), current smoking (OR, 2.31; 95% CI, 1.97 to 2.71), increased waist-to-hip ratio (OR for first versus third tertile, 2.49; 95% CI, 1.97 to 3.14), and increased ratio of apolipoprotein B to A-1 (OR for first versus third tertile, 2.31; 95% CI, 1.83 to 2.94) were associated with higher risk of acute myocardial infarction. Daily consumption of fruits or vegetables (OR, 0.63; 95% CI, 0.51 to 0.78) and regular exercise (OR, 0.67; 95% CI, 0.55 to 0.82) reduced the risk of acute myocardial infarction. Abdominal obesity, abnormal lipids, and smoking were associated with high population-attributable risks of 48.5%, 40.8%, and 38.4%, respectively. Collectively, these risk factors accounted for 88% of the population-attributable risk. Conclusions— Interventions aimed at decreasing behavioral risk factors, lowering blood pressure, and modifying lipids could have a large impact on the risk of acute myocardial infarction among Latin Americans.
Myocardial Response to Incremental Exercise in Endurance‐Trained Athletes: Influence of Heart Rate, Contractility and the Frank‐Starling Effect

Recent evidence indicates that endurance‐trained athletes are able to increase their stroke volume (SV) throughout incremental upright exercise, probably due to a progressively greater effect of the Frank‐Starling mechanism. This is contrary to the widely held belief that SV reaches a plateau at a submaximal heart rate (irrespective of fitness level), owing to a limitation in the time for diastolic filling. The purpose of this investigation was to evaluate whether endurance‐trained athletes rely on a progressively greater effect of the Frank‐Starling mechanism throughout incremental exercise. A secondary purpose was to evaluate the effects of postural position on the cardiovascular responses to incremental exercise. Ten male cyclists participated in this investigation. Left ventricular function was assessed throughout incremental exercise in the supine and upright positions (counterbalanced) using radionuclide ventriculography. Stroke volume increased in a linear fashion during incremental exercise in both the upright and supine positions. The increases in cardiac output (Q) throughout incremental to maximal exercise (in both the supine and upright positions) were significantly related to changes in heart rate, myocardial contractility and the Frank‐Starling mechanism. Percentage changes in end‐diastolic volume and SV were significantly greater in the upright position versus the supine position, reflecting an increased reliance on the Frank‐Starling effect to increase Q. We conclude from this investigation that highly trained endurance athletes are able to make progressively increasing usage of the Frank‐Starling effect throughout incremental exercise. Postural position has a significant effect on the relative contribution of heart rate, myocardial contractility and the Frank‐Starling mechanism to the increase in Q during exercise conditions.
IS THAT REALLY AN HONEST ONLINE REVIEW? THE EFFECTIVENESS OF DISCLAIMERS IN ONLINE REVIEWS

Due to an increase in manipulated online reviews, giant e-vendors such as Amazon.com, are trying ways to deter untruthful online reviews. One of their strategies was to make sure that the consumers include disclaimers that products received were free or discounted. This article calls for an investigation of the use of disclaimers on online reviews that post challenges, opportunities, and promises for social commerce such as Amazon.com. This study aims to develop an understanding of social commerce-related phenomena and to provide online retailers best practices when integrating social commerce as part of their marketing plan.
Integrated Management in Tourism: The Role of Coopetition

ABSTRACT The paper explores the nature of integrated management placing attention on the role of coopetition in the destination management. Integrated management is a type of governance based on interorganizational coopetition networks aimed at improving competitiveness. An exploratory qualitative based on multi-case analysis of two Brazilian tourism destinations examined the social organization of the tourism sector, the characteristics of networks and their practices, and production relations. Four categories of analysis were verified, namely Policy, Process, Activity, management and Resolution was verified. Data were obtained from three sources: interviews with managers of tourism associations and entrepreneurs, non-participant observation, and content analysis of documents. The comparative study reveals important differences in integrated management are due to the consolidation of coopetition networks, which work as a central hub to facilitate integrated management.
Patients with halitosis of an Evaluation of Halitosis in Children and Mothers

Purpose: The purpose of this study was to investigate the occurrence and clinical parameters that are associated with halitosis in pediatric dental patients and compare these findings with those found for the patients’ mother. Methods: Children aged 5 to 12 years old were evaluated with mothers present during a dental visit. Each mother completed the child’s medical history and a breath odor questionnaire. The mother and an oral breath judge (OBJ) evaluated the child’s oral breath using organoleptic methods. A commercial breath analyzer (CBA) measured the oral and nasal levels of volatile sulfur compounds (VSCs) for child and mother before and after tongue debridement. A number of oral parameters were recorded for the children. Results: Thirty children (mean age=8.8 years) and 18 mothers participated. Halitosis (VSC>100 parts per billion, or ppb) was found in 23% of children and 11% of mothers, but was not significantly correlated. In contrast, 61% of mothers reported halitosis in themselves and their child. Significant differences were found between VSC levels and frequency of tooth-brushing (P<.05, univariate ANOVA). There was significant correlation in the detection of breath odor between mother and OBJ (P<.05, Pearson); however, there was no significant correlation between evaluators and CBA. A positive correlation existed between the presence of interproximal restorations and breath odor by OBJ (P<.05, Pearson). Conclusions: Halitosis may be a problem in some healthy children, but it does not correlate well with mothers’ breath odor or common oral parameters. The organoleptic and CBA results were inconsistent, suggesting factors other than VSCs may be associated with halitosis in children. (Pediatr Dent. 2003;25:553-558)
An Exploratory Study of Session Limited Models of Therapy Outcomes in an Employee Assistance Program

Employee Assistance Programs (EAPs) have grown increasingly popular over recent years. The prevalence of organizations utilizing and investing in EAP services for their employees has grown; however, companies that purchase EAPs are not wellinformed as to which session-models are most effective for various diagnoses. The current study is the first to explore treatment outcomes of session-limited models (measured by Therapist Perception of Change, TPC) for diagnoses (anxiety and depression) in an EAP delivery system. Outcomes were measured by TPC ratings including: a) Regressed, b) remained at Baseline, c) Improved, and d) issue was Resolved. Analyses (Chi-Square and =t-test) were used to assess TPC ratings across session models (3-8), diagnoses (anxiety and depression), and number of sessions completed. The results found associations between TPC, EAP Session Models, and diagnoses, X2(33, N = 3816) = 87.049, p < . 001. A relationship was found between EAP Session Model completion, and participant outcome (“Resolved” TPC rating), X2(3), N = 3816) = 112.511, p < . 001. It was found that a lower percentage of clients seeking EAP services for a depression diagnosis improved (M = .73, SD = .445) compared to those with an anxiety diagnosis (M = .79, SD = .411), t(3812.732) = 4.078, p < . 001). Therapist ratings of client symptoms did show improvement for both anxiety and depression. The EAP Session Models most associated with therapist ratings of
Factors Related to Body Condition of Nestling Burrowing Owls in Buffalo Gap National Grassland, South Dakota

Abstract We analyzed the body condition of nestling Burrowing Owls (Athene cunicularia) at Buffalo Gap National Grassland during the summers of 1999 and 2000. In 1999, which had a wet spring, body condition was negatively related to brood size and distance from nest to colony edge. There was no relationship between body condition and brood size during 2000, which had normal precipitation. In 2000, nestlings of early arriving pairs were in better body condition than those that arrived later. The variance in body condition within a brood was not related to brood size.
The relationship between leadership, organisational commitment and turnover in the Saudi Arabian banking sector.

The Saudi Arabian banking sector in 2004 comprised eleven banks serving the population. There were 1,216 branches and 4,104 automatic teller machines (ATMs) across the country. The employee number was 31,589 in 2005 (SAMA, 2016). The sector witnessed sign
The Impact of Education and Training, Work Discipline and Organizational Culture on Employee’s Performance: The Study of Disaster Management and Fire Department in Palembang City, Indonesia

This study aims to investigate the impact of education and training, work discipline and organizational culture on employee’s performance. The study is conducted at the Disaster Management and Fire Department Office in Palembang City, Indonesia. There are seven offices of disaster management and fire department officials in all over Palembang city and the total population is 360 firefighters. The sample size is 154 respondents that are taken proportionately from each office. A survey research using questionnaire is employed to collect the data. The variables are education and training (X1), work discipline (X2), organizational culture (X3) and employees’ performance (Y). Technology and labor force changes, service and performance improvement and rules’ adjustment are indicators for education and training. Remuneration, supervision, and firmness are indicators for work discipline. Innovation, people oriented and composure are indicators for organizational culture. Working standard, work equipment and tool and work opportunity are indicators for employees’ performance. A regression equation model is employed. The result reveals that there is a positive and significant effect of education and training, work discipline and organizational culture on employee’s performance.
Transformational Leadership and Job Satisfaction In the Saudi Arabian Technical Colleges

The purpose of this descriptive and cross-sectional analysis is to study leadership profiles of the heads of technical departments in technical colleges in the western region of Saudi Arabia, and explore the relationship between department heads’ transformational leadership behaviours, trainers’ job satisfaction, and some demographic variables. The data were collected through the distribution of one questionnaire among 357 trainers in the five technical colleges in the western region of Saudi Arabia. Three instruments were used in the questionnaire: the Roueche, Baker and Rose (1989) model to assess department chair transformational leadership behaviours; the Mohrman, Cooke, Mohrman, Duncan and Zaltman (1977) model of Morhman-Cooke-Morhman Job Satisfaction Scale (MCMJSS); and a demographic segment. The results shows that the dominant transformational behaviour was (value), with a mean score of 3.89, while (Motivation) was perceived as the weakest of the transformational behaviours with a mean score of 3.75. The analysis support relationship between department heads perceived transformational and college trainers’ job satisfaction.
Human Factor as a Quality Criterion in Secondary Education: An Approach within the Framework of the European Model of Administrative Excellence EFQM

The main purpose of this work is to analyze the perceptions and attitudes of secondary school education units regarding the qualitative characteristics of human resources, both in relation to the existing and the desired situation so that the administration is effectively carried out in the framework of the principles of Total Quality Management (TQM) and based on the specifications that the European Model of Administrative Excellence (EFQM) defines. The survey was conducted in the framework of the quantitative research approach from April 24 to May 26, 2017 by using the anonymous written questionnaire method, which was completed by 214 secondary education teachers in the prefecture of Arcadia. The results of the survey show that moral rewards are low, while financial rewards are completely absent from school units. At the same time, there is a low level of good communication, lack of competition on a personal level, a low degree of cooperation and exchange of views and honesty, while most respondents stated that the above mentioned are quality features that they would wish to be present in school units. Finally, the majority of respondents said that the dissemination of information and the transferring of it through various techniques, the encouraging and supporting of human resources to participate in activities (educational programs, innovative actions) aimed at improving the educational unit are quality features, which the sample prioritizes as very important and imperative to be adopted by the educational units.
N‐Acetyltransferases and the susceptibility to benzidine‐induced bladder carcinogenesis

Dear Sir, A recent publication entitled ‘‘NAT2 slow acetylation and bladder cancer in workers exposed to benzidine’’ reported that individuals with higher levels of N-acetyltransferase 2 (NAT2) are more susceptible to benzidine. Although this conclusion contradicts Cartwright et al. who first reported an association between slow NAT and bladder cancer in workers exposed to benzidine; the data are in agreement with prior studies on how aromatic amines are believed to induce tumors. However, the mechanisms proposed in the present paper are inconsistent with those of previous studies as detailed below.
Generic language and judgements about category membership: Can generics highlight properties as central?

Many languages distinguish generic utterances (e.g., ‘Tigers are ferocious’) from non-generic utterances (e.g., ‘Those tigers are ferocious’). Two studies examined how generic language specially links properties and categories. We used a novel-word extension task to ask if 4- to 5-year-old children and adults distinguish between generic and specific language, and judge that predicating a property of a depicted novel animal using generic language (e.g., ‘Bants have stripes’), rather than non-generic language (e.g., ‘This bant has stripes’) implies a more kind-relevant connection between category and property. Participants were asked to endorse an extension of the label taught to a novel animal matching the target instance on either overall similarity or the mentioned property. Wording was found to have a significant effect on responses for both age groups. Altogether, the results of these studies suggest that the generic may be a default interpretation for young children, who need to learn the semantics of specific and set-theoretic expressions.