Miracle-dz/UniFAR-FTUs huggingface dataset:
Toward measurement display content for improving intrinsic motivation in smart health equipment

To help prevent lifestyle-related diseases, it is essential to understand spontaneous behavior in daily life. The development of various kinds of wearable health equipment in recent years has led to the ability to measure a wide range of activities and to display the measurement results visually. With a focus on intrinsic motivation, the present paper aims to clarify what kinds of information provided by such devices are useful for promoting the long-term continuation of activities. We conducted laboratory experiments to impose a simple problem on the participants and clarify the effect of feedback on trends in answer results. The experimental results indicate that long-term-feedback tends to be effective, but that the presentation of accurate results is not necessarily effective for improving intrinsic motivation. These experimental findings give us unexpected points to decide the content of the indication of health activity amount to make use of to improve lifestyle habits.
Antigen-loaded monocyte administration induces potent therapeutic anti-tumor T cell responses.

Efficacy of dendritic cell (DC) cancer vaccines is classically thought to depend on their antigen-presenting cell (APC) activity. Studies show, however, that DC vaccine priming of cytotoxic T lymphocytes (CTL) requires the activity of endogenous DC, suggesting that exogenous DC stimulate anti-tumor immunity by transferring antigen (Ag) to endogenous DC. Such Ag transfer functions are most commonly ascribed to monocytes, implying that undifferentiated monocytes would function equally well as a vaccine modality and need not be differentiated to DC to be effective. Here, we used several murine cancer models to test the anti-tumor efficacy of undifferentiated monocytes loaded with protein or peptide Ag. Intravenously injected monocytes displayed anti-tumor activity superior to DC vaccines in several cancer models, including aggressive intracranial glioblastoma. Ag-loaded monocytes induced robust CTL responses via Ag transfer to splenic CD8+ DC in a manner independent of monocyte APC activity. Ag transfer required cell-cell contact and the formation of connexin 43-containing gap junctions between monocytes and DC. These findings demonstrate the existence of an efficient gap junction-mediated Ag transfer pathway between monocytes and CD8+ DC and suggest that administration of tumor Ag-loaded undifferentiated monocytes may serve as a simple and efficacious immunotherapy for the treatment of human cancers.
Differential Evolution Optimization Algorithm Based on Generation Systems Reliability Assessment Integrated with Wind Energy

Generating systems are said to be adequately reliable when they can satisfy the load demand. Meanwhile, the reliability of electrical systems is currently being influenced by the increasing acceptance of "Wind Energy Conversion System" (WECS) in power systems compared to other conventional sources. This stuffy proposed a novel optimization method labeled the "Differential Evolution Optimization Algorithm" (DEOA) to assess the reliability of power generation systems (PGS). The DEOA technique is used to improve the assessment of the reliability and adequacy of the generation systems by incorporating wind energy from a WECS. The basis of DEOA is the meta- heuristic searching used to simulate the generation systems operation and considering the random failures of existing systems and the unstable character of WECS- sourced wind energy. The effectiveness of the suggested algorithm to assess the reliability and adequacy of power generation systems with WECS was demonstrated. Additionally, the efficiency of the planned algorithm in numerical simulation was compared to that of the "Monte Carlo simulation" (MCS).
Group A streptococcal infections in children

With the advent of antimicrobials during World War II, and a natural decline that began before then, dread diseases began to assume a less important role, especially in industrialised countries. By the 1970s, acute rheumatic fever and acute glomerulonephritis were rarely seen, even though acute streptococcal infections continued to occur with their usual frequency and severity. In the 1980s, attention was once again focused on infections caused by group A streptococcus and its sequelae. The most common infections caused by group A streptococcus are pharyngitis and pyoderma, which occur in children particularly.
Efecto de la lactancia materna en la calidad de vida y en el desarrollo de la dermatitis atópica

Introduccion: la dermatitis atopica (DA) es una patologia de prevalencia creciente y de gran repercusion social. Siendo su etiologia de origen multifactorial, analizamos si factores ambientales, especialmente la lactancia materna (LM), intervienen en su desarrollo y evolucion. Los objetivos son evaluar la gravedad clinica y la calidad de vida de los ninos con DA, detectar diferencias en la edad de diagnostico segun el tipo de lactancia recibida y estimar la asociacion de padecer DA segun las variables de interes analizadas. Material y metodos: estudio de casos y controles apareado por edad y sexo en poblacion infantil de Atencion Primaria. Se realiza mediante el cumplimiento de tres cuestionarios a ninos que acuden a las revisiones de salud establecidas por la Conselleria de Sanidad de Valencia. Los datos recogidos se analizaran con el programa SPSS®. Resultados: la DA se presenta mas precozmente en los varones. Se observo un efecto protector de la LM frente a la lactancia artificial (LA) sobre el desarrollo de la DA (odds ratio [OR]: 0,15; intervalo de confianza del 95% [IC 95%]: 0,09-0,24), frente a procesos de alergia al polen o rinitis alergica (OR: 0,35; IC 95%: 0,17-0,73), frente a la piel seca (OR: 0,22; IC 95%: 0,14-0,36), al picor (OR: 0,50; IC 95%: 0,27-0,93) y paralelamente en la repercusion de caracteristicas clinicas y en la calidad de vida (puntuacion del cuestionario Indice de Calidad de Vida de la Dermatitis Atopica Infantil [ICVDAI]: 2,3 ±3,5 frente a 0,7 ±0,1; p<0,001). Conclusion: la eleccion de la LM mejora la calidad de vida en los ninos, protege frente a la aparicion de DA, de alergia al polen o rinitis alergica y frente a algunas caracteristicas clinicas cutaneas.
Is only Thyroid Peroxidase Antibody Sufficient for Diagnosing Chronic Lymphocytic Thyroiditis?

Objectives: Recently, only anti-thyroid peroxidase (anti-TPO) has been suggested as an autoantibody in the diagnosis of chronic lymphocytic thyroiditis (CLT). In contrast, anti-thyroglobulin (anti-Tg) positivity has also been reported to be important. To evaluate this relationship more clearly, we planned to retrospectively investigate the autoantibody levels of the patients who underwent thyroid surgery for various reasons and those with CLT in postoperative pathology. Methods: We evaluated 670 patients who underwent thyroid surgery (total/subtotal thyroidectomy) for various reasons at our hospital between January 2015 and March 2017. Patients with indications of Graves’ disease, toxic multinodular goiter, and all malignancies except for thyroid papillary carcinoma (TPC) were excluded. Eighty-nine patients whose pathology findings were compatible with CLT and preoperative thyroid autoantibodies were identified enrolled in to the study. Patients with absence and presence of thyroid antibodies were included in the seronegative CLT group and seropositive CLT group, respectively. In addition, patients were divided into thyroid papillary carcinoma (TPC) and benign groups. Results: According to the study criteria, 89 (83 females, six males) (mean age, 46.08±11.19 years) patients who had preoperatively identified autoantibodies were detected. Anti-TPO positivity was found in 47 (52.8%) cases, whereas anti-Tg positivity was found in 49 (55.1%). Only anti-TPO positivity was found in 18 (20.2%) cases, whereas only anti-Tg positivity was detected in 20 (22.5%). Twenty-two (24.7%) of the patients were seronegative. On comparing the seronegative and seropositive groups, seronegativity was more frequent in male patients (p=0.03). Thyroid-stimulating hormone was found to be significantly higher in the seropositive group (p=0.01). TPC was detected in 36 (40.4%) of all cases. No difference regarding age, thyroid function tests, and antibody levels was found between the benign and TPC groups. Conclusion: Although all of our cases were histopathologically diagnosed with CLT, serologically, 75.3% of thyroid autoimmunities could be shown when both antibodies were evaluated together. When only anti-TPO was considered, this rate decreased to 52.8%. Therefore, anti-Tg appears to be still important in showing autoimmunity. Prospective studies are needed to evaluate this relationship more clearly.
A simulation tool for energy management of e-mobility in urban areas

In this paper we describe a simulation tool developed to study city wide scenarios of e-mobility. The tool is intended to support e-mobility stakeholders in finding effective solutions to facilitate a widespread and sustainable EV adoption in urban areas. The tool includes a suite of integrated models designed to reproduce e- mobility pattern, charging behaviour and resulting impact on electricity demand at a high spatiotemporal resolution. The suite also includes models to evaluate multimodal mobility approaches and smart charging strategies including the use of renewable energy. The simulation tool has been tested in the metropolitan area of Rome (IT). We have used large scale collections of vehicle trajectory data to calibrate and validate the suite of models.
Influence of culture on E-commerce and vice versa

Electronic commerce (e-commerce) is useful for both businesses and consumers by removing time, space and geographical location barriers. There are bigger choices, chipper prices and completely new products are obtainable in many product categories to consumers who may be actually far away from the traditional stores. Furthermore, the nature of Information technology applications and ecommerce, lead to more information sharing, facilitate transactions, and provide convenience of purchasing. As a result, this day, ecommerce is not only the way of business but also a competitive advantage. However, to achieve higher efficiency, either all international e-commerce society should share similar culture or there must be an adaptation with respect to each culture. In this regard, a lot still remains to be investigated as to how individual e-commerce national society differs and which organizational cultures are appropriate to ecommerce business. Hence, the objective of this paper is to move ahead our understanding on how e-commerce is being influenced by culture and the other way round. We propose that e-commerce leads to, professional /rational behavior, market culture and centralization. It opposes person support culture. We also hypothesize that, the effects of power distance and individualism on e-commerce, decrease with ecommerce experience.
Marine Bacteria from Rocas Atoll: A Promising Biotechnological Resource

Rocas Atoll is a unique environment in the Equatorial Atlantic Ocean, hosting a large 23 number of endemic species and studies on the chemical diversity emerging from this biota are rather 24 scarce. Therefore, the present work aims to assess the metabolomic diversity and pharmacological 25 potential of the microbiota from Rocas Atoll. A total of 76 bacteria were isolated and cultured in 26 liquid culture media to obtain crude extracts. About one third (34%) of these extracts were 27 considered cytotoxic against human colon adenocarcinoma HCT-116 cell line. 16S rRNA gene 28 sequencing analysis revealed that the bacteria producing cytotoxic extracts are mainly from the 29 Actinobacteria phylum, including Streptomyces, Salinispora, Nocardiopsis and Brevibacterium genera, 30 and in a smaller proportion from Firmicutes phylum (Bacillus). The search in the GNPS spectral 31 library unveiled a high chemodiversity being produced by these bacteria, including rifamycins, 32 antimycins, desferrioxamines, ferrioxamines, surfactins, surugamides, staurosporine and 33 saliniketals, along with several unidentified compounds. Using an original approach, molecular 34 network successfully highlighted groups of compounds responsible for the cytotoxicity of crude 35 extracts. DEREPLICATOR+, a recently developed in silico tool (GNPS), allowed the identification 36 of derivatives of the macrolide novonestimycin, as the cytotoxic compounds into the extracts 37 produced by Streptomyces BRB-298 and BRB-302. Overall, these results highlighted the 38 pharmacological potential of bacteria from this singular Atoll. 39
Exploring Why Organisations Differ in Board Configuration: Do Organisations’ Age, Size and their Years Being Public Matter? Findings from Greek Listed Manufacturing Organisations

In this paper building upon several theories (agency theory, stakeholder theory and resource dependence theory) and by utilising data from 161 Greek manufacturing companies that were listed in the Athens Stock Exchange on the 31st December 2008, we explore the relationships between the organisational characteristics of the firms (organisational age, organisational size and years listed in the stock market) and the Board configuration (board size, board leadership structure and directors’ dependence/independence). Both descriptive and inferential statistics (ANOVA tests) were utilised to answer the research questions. Interestingly and in alignment with the literature, the findings showed that larger organizations tend to have larger boards and greater proportions of external and independent directors. However, no more strong relationships have been identified between the organisational characteristics and the board configuration. Finally, it is worth mentioning that this study examines the listed Greek manufacturing companies during very turbulent times, the start of the financial crisis in Greece, which may have an impact on the configuration of the boards at that time.
Tumor suppressive BTB/POZ zinc-finger protein ZBTB28 inhibits oncogenic BCL6/ZBTB27 signaling to maintain p53 transcription in multiple carcinogenesis

Zinc-finger and BTB/POZ domain-containing family proteins (ZBTB) are important transcription factors functioning as tumor suppressors or oncogenes, such as BCL6/ZBTB27 as a key oncoprotein for anti-cancer therapy. Through epigenome study, we identified ZBTB28/BCL6B/BAZF, a BTB/POZ domain protein highly homologous to BCL6, as a methylated target in multiple tumors. However, the functions and mechanism of ZBTB28 in carcinogenesis remain unclear. Methods: ZBTB28 expression and methylation were examined by reverse-transcription PCR and methylation-specific PCR. The effects and mechanisms of ectopic ZBTB28 expression on tumor cells were assessed with molecular biological and cellular approaches in vitro and in vivo. Results: Albeit broadly expressed in multiple normal tissues, ZBTB28 is frequently downregulated in aero- and digestive carcinoma cell lines and primary tumors, and correlated with its promoter CpG methylation status. Further gain-of-function study showed that ZBTB28 functions as a tumor suppressor inhibiting carcinoma cell growth in vitro and in vivo, through inducing cell cycle arrest and apoptosis of tumor cells. ZBTB28 suppresses cell migration and invasion by reversing EMT and cell stemness. ZBTB28 transactivates TP53 expression, through binding to the p53 promoter in competition with BCL6, while BCL6 itself was also found to be a direct target repressed by ZBTB28. Conclusion: Our results demonstrate that ZBTB28 functions as a tumor suppressor through competing with BCL6 for targeting p53 regulation. This newly identified ZBTB28/BCL6/p53 regulatory axis provides further molecular insight into carcinogenesis mechanisms and has implications in further improving BCL6-based anticancer therapy.
Exploring Factors Influencing the Proportion of E-hailing Taxi Trips: A Study Based on Fractional Response Model

Traditional taxi has been criticized for underserving regions far away from downtown, leading to social inequity. However, there has been no evidence so far to support this argument. With the advent of e-hailing taxi services such as Uber and Lyft, it becomes possible to test this argument. Because e-hailing taxi trips are assigned to the drivers who are willing to undertake the rides, the e-hailing taxi trips plus the traditional taxi trips can be regarded as the true travel demand served by taxi. The proportion of e-hailing taxi trips to total taxi trips is used as an indicator of to what extent area is underserved by traditional taxi. All the origins of traditional taxi and e-hailing taxi trips in New York City from January 2015 to December 2017 are aggregated at the level of taxi zones, which is defined by the New York City Taxi Limousine Commission. Fractional Response Model (FRM) is used to identify factors that influence the proportion of e-hailing trips. Results show that the proportion of African-American, the proportion of households of income less than 50,000 dollars, the proportion of household of income between 100,000 to 200,000 dollars, road density, distance to the Midtown Center have positive impact on the proportion of e-hailing taxi trips, while the population density, subway station density, bus station density, existence of airport have negative impact on the proportion of e-hailing taxi trips.
INTRODUCING MACHINE TRANSLATION IN TRANSLATOR TRAINING: COMPARING “INFORMATION MINING” WITH POST-EDITING

This paper presents the results of an experiment to introduce translation students to statistical machine translation (SMT) by comparing post-editing it with using traditional documentation methods (“information mining”). At the beginning of an introductory course on translation technologies, the students translated a text in English or Spanish and annotated instances where the use of a particular electronic reference tool that they previously learned about helped them hand-pick a suitable translation solution. At the end of the course, the students revisited the same text and selected passages they had spent considerable time and effort translating, as evidenced by their annotations. They fed these passages into the open-domain SMT system Google Translate (GT) and then post-edited the output. This paper compares the students’ annotated handpicked translation solutions with the corresponding unedited GT ones (to assess differences in quality) and with the post-edited renditions of GT’s solutions (to analyze whether the students’ decisions to accept or reject the MT solutions resulted in quality gains or losses). According to the results, the quality of the unedited MT solutions was on average just below that of the students’ own solutions, and post-editing resulted in a slight average increase in quality when compared with information mining.
Esophageal Foreign Bodies: An Experience with Rigid Esophagoscope

Background: Foreign body impaction in the upper aero-digestive tract is a common presenting problem to the ENT surgeons. We studied the results of rigid esophagoscopy for esophageal foreign bodies. Methodology: This descriptive study was carried out in Saidu Teaching Hospital, Swat, from January 2006 to June 2009. Patients with history of foreign body impaction were included. Esophagoscopies were performed by ENT consultant with rigid esophagoscope. Age, sex, type of foreign body, site of impaction and underlying pathology were recorded. Dilatation of the strictures and webs was carried out. Biopsies were taken where indicated. Patients were kept in ward for 24 hours for observation after procedure. Results: Among 212 patients, 132(63%) were males and 80(38%) females. Of these 128(60.26%) were 50, and 39(18.39%) in middle age groups. Coins 118(55.6%) were the most common foreign bodies followed by meat bolos 44(20.75%), dentures 15(7.07%), fish bone 15(7.07%), chicken bone 10(4.7%), battery cell, peach seeds artificial jewelry 2 each (0.94%), marble ball and bone chip 1 each (0.47%). Out of 212 patient 185 had no pathology while 27(12.73%) had underlying pathology; webs 9(4.74%), malignant neoplasm 7(3.30%), benign stricture 8(3.7%), achalasia, diverticulum and neopharynx 1 each (0.47%). In 202(95.28%) foreign body was removed, while in 10(4.07%) these passed spontaneously. Webs and benign strictures were successfully dilated. Biopsies were taken in 15(7%). No mortality and mild odynophagia was encountered. Conclusion: Rigid endoscopy is still a gold standard diagnostic and therapeutic tool for upper aerodigestive tract pathologies. A second look after foreign body removal is essential to exclude any underlying pathology.
Specialization In The Neoclassical Model Allowing For Variable Capital Utilization

We study how specialization, measured by industry shares in GDP, is a¤ected by technology and factor endowments. A exible speci cation, pioneered by Kohli (1991) and used by Harrigan (1997), makes it possible to combine technology and factor endowments in the estimating equation, thus combining the Ricardian and Heckscher-Ohlin explanations for specialization. By allowing variable capital utilization and sector-speci c capital, our methodology permits estimation using short-span high-frequency data, which is the only kind of data currently available for industry-level studies in international economics. We calculate capital utilization from the consumption of electricity following Burnside, Eichenbaum and Rebelo (1995a) and Baxter and Farr (2001b). In the process of calculating capital utilization we calculate the e¢ ciency of electricity consumption in each country and industry. To estimate the model we compile data for 8 two-digit industries in 23 countries over 21 years. We show that if we were to ignore variable capital utilization, the e¤ects of technology on specialization would be signi cantly overestimated. The overestimation is greater if we assume that capital is a speci c factor as opposed to being freely mobile between industries. We also nd that once the variable capital utilization has been accounted for, the assumption about mobility of capital has little e¤ect on the technology coe¢ cients. Using the example of several countries, we show that allowing variable capital utilization changes the explanation of the specialization patterns that we observe in the dataset. For some countries and industries, the accumulation of physical capital, rather than the technology, becomes the most important determinant of industry share.
Plagiarism And Culture: Are They Closely Related To Each Other?

Several researchers conclude that plagiarism is culturally approved in non-Western countries. This study is conducted to investigate this claim. Participants of this study are M.A students in the field of Applied linguistics enrolled in the Libyan Academy of Graduate studies in Misurata, Libya. All have had experience in teaching English in Libyan schools for at least 4 years. Six of them work as part-time teachers at Misurata university where they teach Technical English and ESP courses. A survey and semi-structured interviews were conducted to see if their culture encourages or permits plagiarism. Responses reveal that plagiarism is morally and academically unacceptable in Libya. Participants emphasize that they try not to quote without giving credit to the author(s). Meanwhile, they admit that some of their colleagues and students do not commit themselves to the academic integrity of research ethics. However, they do not relate this violation to cultural values. It is, according to them, because of lack of understanding of the act, deficiency in their educational backgrounds, and inability to express themselves freely in English. This study articulates the implications with recommendations to university instructors and education policy makers and future research. Plagiarism, Culture, Learning Styles, Research Ethics.