Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of low dose methotrexate on the bone mineral density of patients with rheumatoid arthritis.

OBJECTIVE To determine the effects of low dose methotrexate (MTX) on bone mineral density (BMD) of patients with rheumatoid arthritis (RA). METHODS We examined the relationship between BMD and disease modifying antirheumatic drug (DMARD) use with data from a prospective, randomized, placebo controlled trial assessing the effects of calcium and vitamin D3 supplementation on BMD of patients with RA. Measurements of BMD of the lumbar spine and femoral neck were performed at baseline and at yearly followup visits over 3 years. RESULTS Information about DMARD use and BMD was available for 133 patients at baseline, and for 95 patients at Year 3. Lumbar spine and femoral neck BMD of MTX and non-MTX treated patients were similar at the start of the study. At the end of 3 years of followup, there was no significant differences in the change in BMD of the femoral neck and lumbar spine in MTX and non-MTX treated patients, in general. However, patients treated with prednisone > or = 5 mg/day plus MTX had greater loss of BMD in the lumbar spine than patients treated with a similar dose of prednisone without MTX (difference -8.08% over 3 years; p = 0.004). CONCLUSION At the end of 3 years, low dose MTX use was not associated with change in femoral neck or lumbar spine BMD in patients who were not treated with corticosteroids. However, among patients treated with prednisone > or = 5 mg/day, combined treatment with MTX and prednisone was associated with greater bone loss in the lumbar spine than treatment with prednisone without MTX.
The provision of home-based palliative care for those with advanced heart failure

Purpose of reviewAlthough widely recognized as best practice for advanced heart failure patients, palliative care is underused by this population. The purpose of this brief review is to highlight recent findings related to home-based palliative care among patients with advanced heart failure. Recent findingsThis review considers new models of home-based palliative care and reports recent evidence on the effectiveness, and burden of these models for patients with advanced heart failure and their caregivers. New models currently under investigation and gaps in current research are presented. SummaryNew models integrating home-based palliative care and standard heart failure care have shown to be effective in reducing both physical and psychological symptoms in patients. Recent evidence suggests that home-based palliative care reduces hospitalizations and decrease the probability of 30-day re-admissions in patients with advanced heart failure; thus, potentially reducing costs of care and increasing likelihood of dying at home. However, caregiver burden for families of those with heart failure remains an issue. Research that addresses caregiver burden and the challenges of providing palliative care to patients with the uncertain disease trajectory seen in advanced heart failure require further research.
No Contagion, Only Interdependence: Measuring Stock Market Comovements

This paper examines stock market co-movements. It begins with a discussion of several conceptual issues involved in measuring these movements and how to test for contagion. Standard tests examine if cross-market correlation in stock market returns increase during a period of crisis. The measure of cross-market correlations central to this standard analysis, however, is biased. The unadjusted correlation coefficient is conditional on market movements over the time period under consideration, so that during a period of turmoil when stock market volatility increases, standard estimates of cross-market correlations will be biased upward. It is straightforward to adjust the correlation coefficient to correct for this bias. The remainder of the paper applies these concepts to test for stock market contagion during the 1997 East Asian crises, the 1994 Mexican peso collapse, and the 1987 U.S. stock market crash. In each of these cases, tests based on the unadjusted correlation coefficients find evidence of contagion in several countries, while tests based on the adjusted coefficients find virtually no contagion. This suggests that high market co-movements during these periods were a continuation of strong cross-market linkages. In other words, during these three crises there was no contagion, only interdependence.
The radiological versatility of fibrous dysplasia: An 8-year retrospective radiographic analysis in a north Indian population

Objective: The aim of this study was to examine the clinical and radiographic presentation of fibrous dysplasia through an 8-year retrospective study in patients who reported to the outpatient unit of the Kothiwal Dental College and Research Centre, Moradabad. Materials and Methods: The clinical file records and radiographs of the patients who reported to the outpatient clinic in the Department of Oral Medicine and Radiology were retrospectively reviewed for histopathologically diagnosed fibrous dysplasia. A detailed analysis of the clinical and radiographic features of the 14 cases retrieved was carried out. Results: Almost all the patients presented with a complaint of swelling on the side of the face. The maxilla was more frequently involved than the mandible. The most common radiographic pattern observed was the ground-glass appearance, followed by orange peel, cotton wool, sunray and thumb print appearance, which leads to a perplex differential diagnosis. Conclusion: Awareness of the versatile features of fibrous dysplasia evident through this study is essential in the accurate diagnosis and proper treatment planning of such lesions.
Analysis of the effects of frequent strikes on academic performance of students in universities in Nigeria: Edo State as a focal point

The history of Academic Staff Union of Universities (ASUU)’s strike can be traced back to 1978, the period of the beginning of the decline in the oil boom, when the country faced the consequences of the failure by its rulers to use the oil wealth to generate production and a social welfare system. Military dictatorship had eroded deeply the basic freedoms in the society. Academic freedom and university autonomy were casualties of military dictatorship. The funding of education, and so of universities, became poorer. The factors required a changed orientation of the union of academics. However, questionnaires were administered to seek the opinions of the students in University of Benin (UNIBEN) and in Benson Idahosa University (BIU), Edo States and one thousand and fifty four staff and students were randomly selected. Nine hundred and seventy one respondents validly returned their questionnaire. From the analyzed data, it was observed that frequent strikes had adverse effects on the academic performance of students. Based on the findings of the study, recommendations were made that adequate measures should be put in place by government and the Academic Staff Union of Universities (ASUU) etc to check incessant strike in the educational system; and conclusively that government owned Universities should emulated private school owners by avoiding strikes and intensify efforts to convince ASUU on the evils of strikes to see that students would have enough time to study so that they can be able to face challenges in the Labour Market. This paper painstakingly appraised several of these issues and concluded that all stakeholders in the education sector and federal polity should thread softly, be objective, rational, altruistic and magnanimous in order not to make the existence of true federalism (social, political, educational and economic cohesive existence of the people, peace and tranquillity) a fleeting illusion and a mirage. Keywords: ASUU, strikes, Academic performance, economic downturn, National Universities Commission
Sarcoplasmic reticulum calcium release compared in slow‐twitch and fast‐twitch fibres of mouse muscle

Experiments were carried out to compare the amplitude and time course of Ca2+ release from the sarcoplasmic reticulum (SR) in intact slow‐twitch and fast‐twitch mouse fibres. Individual fibres within small bundles were injected with furaptra, a low‐affinity, rapidly responding Ca2+ indicator. In response to a single action potential at 16 °C, the peak amplitude and half‐duration of the change in myoplasmic free [Ca2+] (Δ[Ca2+]) differed significantly between fibre types (slow‐twitch: peak amplitude, 9.4 ± 1.0 μM (mean ± S.E.M.); half‐duration, 7.7 ± 0.6 ms; fast‐twitch: peak amplitude 18.5 ± 0.5 μM; half‐duration, 4.9 ± 0.3 ms). SR Ca2+ release was estimated from Δ[Ca2+] with a computational model that calculated Ca2+ binding to the major myoplasmic Ca2+ buffers (troponin, ATP and parvalbumin); buffer concentrations and reaction rate constants were adjusted to reflect fibre‐type differences. In response to an action potential, the total concentration of released Ca2+ (Δ[CaT]) and the peak rate of Ca2+ release ((d/dt)Δ[CaT]) differed about 3‐fold between the fibre types (slow‐twitch: Δ[CaT], 127 ± 7 μM; (d/dt)Δ[CaT], 70 ± 6 μM ms−1; fast‐twitch: Δ[CaT], 346 ± 6 μM; (d/dt)Δ[CaT], 212 ± 4 μM ms−1). In contrast, the half‐duration of (d/dt)Δ[CaT] was very similar in the two fibre types (slow‐twitch, 1.8 ± 0.1 ms; fast‐twitch, 1.6 ± 0.0 ms). When fibres were stimulated with a 5‐shock train at 67 Hz, the peaks of (d/dt)Δ[CaT] in response to the second and subsequent shocks were much smaller than that due to the first shock; the later peaks, expressed as a fraction of the amplitude of the first peak, were similar in the two fibre types (slow‐twitch, 0.2–0.3; fast‐twitch, 0.1–0.3). The results support the conclusion that individual SR Ca2+ release units function similarly in slow‐twitch and fast‐twitch mammalian fibres.
Global‐change drivers of ecosystem functioning modulated by natural variability and saturating responses

Humans are altering global environment at an unprecedented rate through changes in biodiversity, climate, nitrogen cycle, and land use. To address their effects on ecosystem functioning, experiments most frequently explore one driver at a time and control as many confounding factors as possible. Yet, which driver exerts the largest influence on ecosystem functioning and whether their relative importance changes among systems remain unclear. We analyzed experiments in the Patagonian steppe that evaluated the aboveground net primary production (ANPP) response to manipulated gradients of species richness, precipitation, temperature, nitrogen fertilization (N), and grazing intensity. We compared the effect on ANPP relative to ambient conditions considering intensity and direction of manipulations for each driver. The ranking of responses to drivers with comparable manipulation intensity was as follows: biodiversity>grazing>precipitation>N. For a similar intensity of manipulation, the effect of biodiversity loss was 4.0, 3.6, and 1.5, times larger than N deposition, decreased precipitation, and increased grazing intensity. We interpreted our results considering two hypotheses. First, the response of ANPP to changes in precipitation and biodiversity is saturating, so we expected larger effects when the driver was reduced, relative to ambient conditions, than when it was increased. Experimental manipulations that reduced ambient levels had larger effects than those that increased them. Second, the sensitivity of ANPP to each driver is inversely related to the natural variability of the driver. In Patagonia, the ranking of natural variability of drivers is as follows: precipitation>grazing>temperature>biodiversity>N. So, in general, the ecosystem was most sensitive to drivers that varied the least. Comparable results from Cedar Creek (MN) support both hypotheses and suggest that sensitivity to drivers varies among ecosystem types. Given the importance of understanding ecosystem sensitivity to predict global‐change impacts, it is necessary to design new experiments located in regions with contrasting natural variability and that include the full range of drivers.
On the difference between permutation polynomials over finite fields

The well-known Chowla and Zassenhaus conjecture, proven by Cohen in 1990, states that if $p>(d^2-3d+4)^2$, then there is no complete mapping polynomial $f$ in $\Fp[x]$ of degree $d\ge 2$. For arbitrary finite fields $\Fq$, a similar non-existence result is obtained recently by I\c s\i k, Topuzo\u glu and Winterhof in terms of the Carlitz rank of $f$. Cohen, Mullen and Shiue generalized the Chowla-Zassenhaus-Cohen Theorem significantly in 1995, by considering differences of permutation polynomials. More precisely, they showed that if $f$ and $f+g$ are both permutation polynomials of degree $d\ge 2$ over $\Fp$, with $p>(d^2-3d+4)^2$, then the degree $k$ of $g$ satisfies $k \geq 3d/5$, unless $g$ is constant. In this article, assuming $f$ and $f+g$ are permutation polynomials in $\Fq[x]$, we give lower bounds for $k %=\mathrm{deg(h)} $ in terms of the Carlitz rank of $f$ and $q$. Our results generalize the above mentioned result of I\c s\i k et al. We also show for a special class of polynomials $f$ of Carlitz rank $n \geq 1$ that if $f+x^k$ is a permutation of $\Fq$, with $\gcd(k+1, q-1)=1$, then $k\geq (q-n)/(n+3)$.
Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials.

BACKGROUND Conflicting reports exist in the medical literature regarding the association between industry funding and published research findings. In this study, we examine the association between industry funding and the statistical significance of results in recently published medical and surgical trials. METHODS We examined a consecutive series of 332 randomized trials published between January 1999 and June 2001 in 8 leading surgical journals and 5 medical journals. Each eligible study was independently reviewed for methodological quality using a 21-point index with 5 domains: randomization, outcomes, eligibility criteria, interventions and statistical issues. Our primary analysis included studies that explicitly identified the primary outcome and reported it as statistically significant. For studies that did not explicitly identify a primary outcome, we defined a "positive" study as one with at least 1 statistically significant outcome measure. We used multivariable regression analysis to determine whether there was an association between reported industry funding and trial results, while controlling for study quality and sample size. RESULTS Among the 332 randomized trials, there were 158 drug trials, 87 surgical trials and 87 trials of other therapies. In 122 (37%) of the trials, authors declared industry funding. An unadjusted analysis of this sample of trials revealed that industry funding was associated with a statistically significant result in favour of the new industry product (odds ratio [OR] 1.9, 95% confidence interval [CI] 1.3-3.5). The association remained significant after adjustment for study quality and sample size (adjusted OR 1.8, 95% CI 1.1-3.0). There was a nonsignificant difference between surgical trials (OR 8.0, 95% CI 1.1-53.2) and drug trials (OR 1.6, 95% CI 1.1-2.8), both of which were likely to have a pro-industry result (relative OR 5.0, 95% CI 0.7-37.5, p = 0.14). INTERPRETATION Industry-funded trials are more likely to be associated with statistically significant pro-industry findings, both in medical trials and surgical interventions.
Immobilization of Heavy Metals in Sewage Sludge during Land Application Process in China: A Review

The safe disposal of sewage sludge during the process of municipal wastewater treatment has become one of the major concerns of increased production. Land application was thought of as a more economical method for sewage sludge disposal than landfill and incineration. However, the presence of heavy metals in sewage sludge restricted the use of land application. The environmental risk of heavy metals was dependent on their contents, chemical speciations, and soil characteristics. Composting and chemical immobilization were the commonly used methods to immobilize the heavy metals in sewage sludge. The immobilization mechanism and speciation transformation of heavy metals during the composting process were presented. Aluminosilicate, phosphorus-bearing materials, basic compounds, and sulfides were reviewed as the commonly used chemical immobilizing agents. The problems that occur during the immobilization process were also discussed. The combination of different methods and the modification of chemical immobilizing agents both improved the fixation effect on heavy metals.
Rate of glycolysis during ischemia determines extent of ischemic injury and functional recovery after reperfusion.

The efficacy of increasing glycolysis during ischemia for enhancing the salutary effects of reperfusion was evaluated in isolated perfused rabbit hearts subjected to low-flow ischemia followed by reperfusion. Control hearts were perfused with buffer containing 0.4 mM palmitate, 5 mM glucose, and 70 mU/l insulin. Additional groups of hearts were perfused with double glucose/insulin and 1 mM dichloroacetate or were subjected to substrate priming to increase preischemic glycogen content. Ischemic contracture was completely prevented in hearts perfused with high glucose/insulin and was delayed markedly by either dichloroacetate or enhanced preischemic glycogen [45 +/- 14 and 31 +/- 20 min, respectively; P < 0.01 each vs. control (11 +/- 10 min)] and inversely related to the rate of lactate production. With reperfusion, recovery of developed pressure was 56 +/- 23% of baseline in control hearts, 90 +/- 8% in hearts receiving high glucose/insulin, 92 +/- 5% in hearts receiving dichloroacetate, and 79 +/- 19% in hearts with increased glycogen (P < 0.05 each vs. control hearts). Creatine kinase release was reduced by > 55% in treated hearts. Thus enhancement of glycolysis by diverse mechanisms during ischemia decreased ischemic damage and improved the recovery of contractile function with reperfusion.
GPs' perceptions of the gender-related barriers to discussing sexual health in consultations: A qualitative study

Objective: This paper explores the barriers related to gender that general practitioners (GPs) face when discussing sexual health matters in primary care consultations. Method: Qualitative study. In-depth interviews were conducted with 22 GPs recruited from different practice types and locations across Sheffield, UK. Transcripts were analysed thematically, assisted by NUD*IST qualitative data analysis programme. Results: GPs were virtually unanimous in believing that patients preferred to see same-sex GPs regarding sexual health, and some felt that as a consequence they became ‘de-skilled’ in dealing with sexual matters of opposite sex patients. Discussion of sexual issues was also perceived to be hindered if the patient was male; for women, reproductive health issues provided an appropriate context to asking about sexual health. Conclusion: Barriers that prevent discussion of sexual matters in consultations can not only impinge upon potential treatment for the patient, but also have an indirect affect on the patient's life, health and intimate relationships. Solutions to overcoming such barriers relate largely to the provision of training for medical students and qualified GPs.
Spatio‐temporal Genetic Structure of a Tropical Bee Species Suggests High Dispersal Over a Fragmented Landscape

Habitat destruction threatens biodiversity by reducing the amount of available resources and connectivity among geographic areas. For organisms living in fragmented habitats, population persistence may depend on dispersal, which maintains gene flow among fragments and can prevent inbreeding within them. It is centrally important to understand patterns of dispersal for bees living in fragmented areas given the importance of pollination systems and recently documented declines in bee populations. We used population and landscape genetic techniques to characterize patterns of dispersal over a large fragmented area in southern Costa Rica for the orchid bee species Euglossa championi. First, we estimated levels of genetic differentiation among forest fragments as ϕPT, an analog to the traditional summary statistic FST, as well as two statistics that may more adequately represent levels of differentiation, G’ST and Dest. Second, we used a Bayesian approach to determine the number and composition of genetic groups in our sample. Third we investigated how genetic differentiation changes with distance. Fourth, we determined the extent to which deforested areas restrict dispersal. Finally, we estimated the extent to which there were temporal differences in allele frequencies within the same forest fragments. Within years we found low levels of differentiation even over 80 km, and no effect of land use type on level of genetic differentiation. However, we found significant genetic differentiation between years. Taken together our results suggest that there are high levels of gene flow over this geographic area, and that individuals show low site fidelity over time.
Identification of the Serratia marcescens hemolysin determinant by cloning into Escherichia coli

A cosmid bank of Serratia marcescens was established from which DNA fragments were cloned into the plasmid pBR322, which conferred the chromosomally encoded hemolytic activity to Escherichia coli K-12. By transposon mutagenesis with Tn1000 and Tn5 IS50L::phoA (TnphoA), the coding region was assigned to a DNA fragment, designated hly, comprising approximately 7 kilobases. Two proteins with molecular weights of 61,000 (61K protein) and 160,000 (160K protein) were expressed by the pBR322 derivatives and by a plasmid which contained the hly genes under the control of a phage T7 promoter and the T7 RNA polymerase. When strongly overexpressed the 160K protein was released by E. coli cells into the extracellular medium concomitant with hemolytic activity. The genes encoding the 61K and the 160K proteins were transcribed in the same direction. Mutants expressing a 160K protein truncated at the carboxy-terminal end were partially hemolytic. Hemolysis was progressively inhibited by saccharides with increasing molecular weights from maltotriose (Mr 504) to maltoheptaose (Mr 1,152) and was totally abolished by dextran 4 (Mr 4,000). This result and the observed influx of [14C]sucrose into erythrocytes in the presence of hemolytic E. coli transformants under osmotically protective conditions suggest the formation of defined transmembrane channels by the hemolysin.
Predation Can Increase the Prevalence of Infectious Disease

Many host‐pathogen interactions are embedded in a web of other interspecific interactions. Recent theoretical studies have suggested that reductions in predator abundance can indirectly lead to upsurges in infectious diseases harbored by prey populations. In this note, we use simple models to show that in some circumstances, predation can actually increase the equilibrial prevalence of infection in a host, where prevalence is defined as the fraction of host population that is infected. Our results show that there is no complete generalization possible about how shifts in predation pressure translate into shifts in infection levels, without some understanding of host population regulation and the role of acquired immunity. Our results further highlight the importance of understanding the dynamics of nonregulatory pathogens in reservoir host populations and the understudied effects of demographic costs incurred by individuals that survive infection and develop acquired immunity.