Miracle-dz/UniFAR-FTUs huggingface dataset:
A Modified Operation for Achilles Tendon Ruptures

Background Treatment of Achilles tendon rupture has long been at the center of debate. Hypothesis A new technique in surgical Achilles tendon repair allows for more stability and earlier rehabilitation. Study Design Case series; Level of evidence, 4. Methods One hundred Achilles tendon rupture patients (70 men, 30 women; age range, 16-54 years; mean age, 32 years) were treated by a newly modified method of repair. Twenty-one of these patients were high-level athletes, and 79 were recreational-level athletes. The average length of follow-up was 2.4 years (range, 1-6.3 years), and none of the ruptures included avulsion fractures. After adjusting the tendon to an adequate length using a Tsuge suture, each fibrous bundle was gathered in a longitudinal direction and fixed with a Bunnell-type suture. The same postoperative physical therapy protocol was applied to all patients: at 1 week, early full weightbearing with a walking cast was initiated, and at 2 weeks, patients began range of motion (ROM) exercises and were instructed to wear a hinged ankle-foot orthosis that permitted full plantar flexion but limited full dorsiflexion. From 6 weeks, patients started practicing double-legged heel raises. Results At an average of 10 weeks, ankle ROM was comparable to that of the nonoperated leg, and double-legged heel raises were achieved at an average of 7.6 weeks. On average, patients were able to do 20 continuous single-legged heel-raising motions (equivalent to manual muscle testing grade 5) at 15.4 weeks, and jogging started at 12.3 weeks. High-level athletes returned to their original sports level at an average of 5 months. Two reruptures (2%) were experienced, but no other complications occurred. Conclusion This surgical technique allows for strong repair stability and subsequent early weightbearing and ROM exercises.
Analysis of lung function and survival in RECAP: An open-label extension study of pirfenidone in patients with idiopathic pulmonary fibrosis.

BACKGROUND RECAP is an open-label extension study evaluating pirfenidone in patients with idiopathic pulmonary fibrosis (IPF) who completed the Phase 3 CAPACITY program. OBJECTIVE We examined the effect of pirfenidone on lung function and survival in patients who were previously randomised to the placebo group in one of the two CAPACITY studies and received pirfenidone for the first time in RECAP. METHODS Eligible patients received oral pirfenidone 2403 mg/day. Forced vital capacity (FVC) was measured at baseline and at weeks 12, 36, and 60. To facilitate comparison with CAPACITY outcomes, analyses were based on patients newly treated with pirfenidone in RECAP who had baseline FVC and carbon monoxide diffusing capacity (DLCO) values that met CAPACITY entry criteria. RESULTS A total of 178 patients were included in the analysis. Among these, 16.3% experienced an FVC decline ≥10% at week 60, compared with 16.8% and 24.8%, respectively, in the CAPACITY pirfenidone (n=345) and placebo (n=347) groups. The mean change from baseline to week 60 in %FVC was -5.9%, compared with -7.0% and -9.4% in the CAPACITY pirfenidone and placebo groups. Overall survival was similar to that of pirfenidone treated patients in CAPACITY. Treatment was safe and generally well tolerated; the type and frequency of adverse events were consistent with previous clinical experience. CONCLUSION FVC and survival outcomes in IPF patients newly treated with pirfenidone in RECAP were similar to those in the CAPACITY pirfenidone group. These data provide further evidence to support the use of pirfenidone in patients with IPF.
Late evening brain activation patterns and their relation to the internal biological time, melatonin, and homeostatic sleep debt

Sleep propensity increases sharply at night. Some evidence implicates the pineal hormone melatonin in this process. Using functional magnetic resonance imaging, brain activation during a visual search task was examined at 22:00 h (when endogenous melatonin levels normally increase). The relationships between brain activation, endogenous melatonin (measured in saliva), and self‐reported fatigue were assessed. Finally, the effects of exogenous melatonin administered at 22:00 h were studied in a double blind, placebo‐controlled crossover manner. We show that brain activation patterns as well as the response to exogenous melatonin significantly differ at night from those seen in afternoon hours. Thus, activation in the rostro‐medial and lateral aspects of the occipital cortex and the thalamus diminished at 22:00 h. Activation in the right parietal cortex increased at night and correlated with individual fatigue levels, whereas exogenous melatonin given at 22:00 h reduced activation in this area. The right dorsolateral prefrontal cortex, an area considered to reflect homeostatic sleep debt, demonstrated increased activation at 22:00 h. Surprisingly, this increase correlated with endogenous melatonin. These results demonstrate and partially differentiate circadian effects (whether mediated by melatonin or not) and homeostatic sleep debt modulation of human brain activity associated with everyday fatigue at night. Hum Brain Mapp, 2009. © 2007 Wiley‐Liss, Inc.
Knowledge, behaviors, attitudes and beliefs of physiotherapists towards the use of psychological interventions in physiotherapy practice: a systematic review

Abstract Purpose: To systematically review and analyze the literature exploring the knowledge, behaviors, attitudes, and beliefs of physiotherapists towards the use of psychological interventions in their practice. Methods: A systematic search was conducted, of articles published between January 1996 and February 2016, using selected electronic databases followed by crosschecking of reference and citation lists. Articles were selected on the basis of the research reported relating to knowledge, behaviors, attitudes or beliefs of physiotherapists towards using a number of different psychological interventions. Quality assessment was conducted by three reviewers independently, and thematic analysis of the included studies was performed. Results: Fifteen studies were included in the analysis. Results indicate that physiotherapists are aware of psychological interventions, are using a variety within practice, and have positive attitudes and beliefs towards their use. However, there are barriers to the incorporation of psychological interventions into their practice, including lack of knowledge, time constraints, and role clarity. The desire for further training was also evident. Conclusion: Notwithstanding the reported awareness and use of psychological interventions in physiotherapy practice, barriers to implementation exist indicating that further research is necessary to address how to effectively equip physiotherapists, to employ such techniques within their scope of practice. Implications for rehabilitation Physiotherapists use and have positive attitudes and beliefs towards a variety of psychological interventions including goal setting, positive, and motivational talk, cognitive behavioral therapy strategies and offering social support. Barriers preventing the incorporation of psychological interventions in practice include, lack of knowledge, time constraints, and role clarity. Despite the use of such interventions, physiotherapists identify the need for further training, to be better equipped to confidently utilize these in practice. These results justify the incorporation of training in psychological interventions in physiotherapist qualifying studies, but also as continued professional development opportunities for physiotherapists currently working in the field.
Beyond Nationalism and Regionalism: The Stability of Economic Voting in Canada

Abstract Previous research has argued that while economic voting is quite consistently found to be an important mechanism in the rest of Canada, it is rather weak in Quebec. Guérin and Nadeau (1998) have demonstrated that whether or not citizens in Quebec vote economically depends on the party system. Following their lead, we expect that the presence of a dominant regionalist party in Quebec after 1993 (the Bloc Québécois) inhibited Quebeckers from voting economically. However, our results do not offer evidence for this hypothesis. Furthermore, we find only weak evidence of economic voting being moderated by voters’ attitudes towards Quebec independence. Our study hence suggests that the impact of economic accountability in Canada is not hindered by a strong regional party or by the salience of the issue of Quebec independence. The economic vote, it seems, is more stable and general than it is regularly argued to be. Résumé Des recherches ont démontré qu'alors que le vote économique est considéré de façon assez constante comme un mécanisme important dans le reste du Canada, il est plutôt faible au Québec. Guérin et Nadeau (1998) ont démontré que, lorsqu'il est exercé en ce sens, un choix de nature économique est dicté chez les citoyens du Québec par le régime des partis. Partant de ce constat, on pourrait penser que la présence prépondérante d'un parti politique régionaliste au Québec après 1993 (le Bloc Québécois) a empêché les Québécois d'exprimer un vote économique. Toutefois, nos résultats ne confortent pas cette hypothèse et nous ne trouvons par ailleurs que des éléments de preuve tenus à l'appui d'un vote économique modéré par les attitudes des électeurs envers l'indépendance du Québec. Notre étude nous amène donc à suggérer que l'incidence de la responsabilisation économique au Canada n'est pas inhibée par un parti régional fort ou par l'importance de la question de l'indépendance du Québec. Le vote économique est, semble-t-il, plus stable et général qu'on ne le prétend habituellement.
Pre-Session Satiation as a Treatment for Stereotypy During Group Activities

Individuals with developmental disabilities may engage in automatically reinforced behaviors that may interfere with learning opportunities. Manipulation of motivating operations has been shown to reduce automatically maintained behavior in some individuals. Considering behavioral indicators of satiation may assist in identifying the point at which an abolishing operation has begun to effect behavior. The purpose of this study was to evaluate the effects of pre-session satiation of automatic reinforcement on subsequent levels of stereotypy and activity engagement during group activities for three males ages 5 to 13 years with developmental disabilities. Following functional analyses with analogue conditions, an alternating treatment design compared a pre-session access to stereotypy condition with a no-pre-session access condition prior to group activity sessions. Results indicated that pre-session satiation of the putative reinforcer produced by stereotypy was effective in decreasing stereotypy and increasing activity engagement during subsequent group activities for all participants. These findings add to the literature supporting the effectiveness of abolishing operations to decrease automatically maintained stereotypy.
Enhancing cognitive performance with repetitive transcranial magnetic stimulation at human individual alpha frequency

We applied rapid‐rate repetitive transcranial magnetic stimulation (rTMS) at individual alpha frequency (IAF) to improve cognitive performance by influencing the dynamics of alpha desynchronization. Previous research indicates that a large upper alpha power in a reference interval preceding a task is related to both large suppression of upper alpha power during the task and good performance. Here, we tested the hypothesis that rTMS at individual upper alpha frequency (IAF + 1 Hz) can enhance alpha power in the reference interval, and can thus improve task performance. Repetitive TMS was delivered to the mesial frontal (Fz) and right parietal (P6) cortex, and as sham condition with 90°‐tilted coil (P6 position). The behavioural effect was assessed in a mental rotation task. Further control conditions were rTMS at a lower IAF (IAF − 3 Hz) and at 20 Hz. The results indicate that rTMS at IAF + 1 Hz can enhance task performance and, concomitantly, the extent of task‐related alpha desynchronization. This provides further evidence for the functional relevance of oscillatory neuronal activity in the alpha band for the implementation of cognitive performance.
Macroeconomic variables and current account balance in Namibia

This paper investigates macroeconomic determinants of the current account balance in Namibia. The results show that there is evidence of twin deficit hypothesis in Namibia. Evidence of twin deficit hypothesis suggest that it is important for Namibia to have fiscal discipline in order to improve its current account. Increase in capital flows, real GDP or per capita, results in a deterioration of the current account. Increase in interest rate, commodity prices and population cause the current account balance to improve. This suggest that contractionary monetary policy contributed to reduction of unproductive imports and improved the current account balance.
Rural Children with Asthma: Impact of a Parent and Child Asthma Education Program

The goal of this study was to determine the effectiveness of an asthma educational intervention in improving asthma knowledge, self-efficacy, and quality of life in rural families. Children 6 to 12 years of age (62% male, 56% white, and 22% Medicaid) with persistent asthma (61%) were recruited from rural elementary schools and randomized into the control standard asthma education (CON) group or an interactive educational intervention (INT) group geared toward rural families. Parent/caregiver and child asthma knowledge, self-efficacy, and quality of life were assessed at baseline and at 10 months post enrollment. Despite high frequency of symptom reports, only 18% children reported an emergency department visit in the prior 6 months. Significant improvement in asthma knowledge was noted for INT parents and young INT children at follow-up (Parent: CON = 16.3; INT = 17.5, p < 0.001; Young children: CON = 10.8, INT = 12.45, p < 0.001). Child self-efficacy significantly increased in the INT group at follow-up; however, there was no significant difference in parent self-efficacy or parent and child quality of life at follow-up. Asthma symptom reports were significantly lower for the INT group at follow-up. For young rural children, an interactive asthma education intervention was associated with increased asthma knowledge and self-efficacy, decreased symptom reports, but not increased quality of life.
Objective and subjective assessment of reciprocal peer teaching in medical gross anatomy laboratory

Reciprocal peer teaching (RPT), wherein students alternate roles as teacher and learner, has been applied in several educational arenas with varying success. Here, we describe the implementation of a reciprocal peer teaching protocol in a human gross anatomy laboratory curriculum. We compared the outcomes of the RPT class with those of previous classes in which RPT was not employed. Objective data (i.e., course grades) show no significant differences in gross anatomy laboratory grades between students in the RPT and non‐RPT classes. To subjectively evaluate the relative success of RPT in the laboratory, we analyzed student opinions obtained through anonymous surveys. These data show that a powerful majority of student respondents felt that RPT was beneficial and should be used in future classes. The greatest disadvantage was unreliable quality of teaching from peers; however, most students still felt that RPT should be continued. Students who felt that they had insufficient hands‐on experience (by virtue of dissecting only half the time) were significantly more likely to recommend abandoning RPT. These results underscore the importance of active student dissection, and suggest that a modified version of the described RPT protocol may satisfy more of the needs of large, diverse student populations. Several hidden benefits of RPT exist for faculty, administration, and students, including reduced need for large numbers of cadavers, attendant reduction in operating costs, and smaller student‐to‐teacher ratios. Anat Sci Educ 2:143–149, 2009. © 2009 American Association of Anatomists.
SerpinB2 Is an Inducible Host Factor Involved in Enhancing HIV-1 Transcription and Replication*

The serine protease inhibitor SerpinB2 (plasminogen activator inhibitor-2) is a major product of activated monocytes and macrophages and is substantially induced during most inflammatory processes. Distinct from its widely described extracellular role as an inhibitor of urokinase plasminogen activator, SerpinB2 has recently been shown to have an intracellular role as a retinoblastoma protein (Rb)-binding protein that inhibits Rb degradation. Here we show that HIV-1 infection and gp120 treatment of human peripheral blood mononuclear cells resulted in induction of SerpinB2. Furthermore, SerpinB2 expression in THP-1 monocyte/macrophage, Jurkat T, and HeLa cell lines increased replication of HIV-1 and enhanced transcription from the HIV-1 long terminal repeat (LTR) promoter by 3–10-fold. Increased HIV-1 gene expression and transcription was also observed in activated macrophages from SerpinB2+/+ mice compared with macrophages from SerpinB2–/– mice. The SerpinB2-mediated elevation of Rb protein levels appeared to be responsible for enhancing transcription from the core promoter region of the LTR by relieving HDM2-mediated inhibition of Sp1 and/or by increasing the Sp1/Sp3 expression ratios. This is the first report associating HIV-1 replication with SerpinB2 expression and illustrates that SerpinB2 is a potentially important inducible host factor that significantly promotes HIV-1 replication.
Automated electronic reminders to improve redosing of antibiotics during surgical cases: comparison of two approaches.

BACKGROUND Timely re-dosing of antibiotic for prolonged surgical cases is an important measure in reducing the risk of surgical site infections. For the anesthesia team, which generally administers the antibiotic re-doses, it is difficult to keep track of and remember the exact timing requirements. We explored the efficacy of two types of electronic reminders to aid the anesthesia team in performing timely antibiotic re-doses. METHODS The first electronic reminder was a timer-triggered "blinking button" feature in the Anesthesia Information Management System (AIMS). The second was generated with a real-time decision support system, the Smart Anesthesia Messenger (SAM). The AIMS reminder was applied for the first five months of the study, whereas the SAM reminder was applied for the second five months. A retrospective analysis was performed to evaluate the efficacy of the reminder messages in improving the antibiotic re-dose success rate. RESULTS In a total of 940 cases, the anesthesia team was reminded of the need for antibiotic re-dosing with AIMS, whereas in 922 cases, the SAM system gave the reminder. The AIMS reminders achieved a timely re-dose success rate of 62.5% ± 1.6%, whereas the SAM reminders achieved a significantly higher success rate: 83.9% ± 3.4% (p < 0.001). CONCLUSIONS Compared with the simple reminders generated with AIMS, the relevant, informative messages generated with SAM were more effective in improving compliance with timely antibiotic re-doses.
It's All About The Money: The Influence Of Family Estrangement, Accommodation Struggles and Homelessness On Student Success in UK Higher Education

Finding, funding and fitting into student accommodation brings multiple and complex challenges for young people who are estranged from their family and cannot depend on their parents for emotional, material or financial support during their time in higher education. This paper draws on the experiences of 564 estranged students in UK higher education, aged 18-25, who have broken communicative contact with their biological or adoptive parents, and who are not recognised as vulnerable by their local authority. It finds that a proportion of estranged students struggle with homelessness issues throughout the student lifecycle. Furthermore, it finds typical student accommodation can be financially out of reach, exacerbated by expectations for students to go home during the summer break. Together these factors push estranged students into a life that is often detached from the institutional community and their peers. Of particular concern is that such factors inhibit a focus on academic studies, with an impact on retention and student success. The paper concludes by outlining how key interventions from higher education providers and government departments can maximise student success for estranged students, in order to inform policy and practice for those who lack family capital and the support of corporate parenting structures.
Why do closed-end funds repurchase stock?

With special institutional characteristics and regulatory requirements, what factors can motivate UK closed-end funds to engage in open-market repurchases? Investigating repurchase transactions on financial-year basis, I find that funds repurchase shares to reduce discounts and to increase the net asset value per share, as directors claim, but not to increase fund liquidity. I also find that funds repurchase shares to increase leverage ratios. Unlike conventional firms, neither distributing excess cash nor substituting dividend payouts promote fund repurchases. Fund size has a negative effect on repurchase decision.
Influencing Factors of Outcome After Lower-Limb Amputation: A Five-Year Review in a Plastic Surgical Department

The crude major lower limb amputation procedure rate is 8.8 per 100,000 of the population per year in Taiwan. From January 2002 to October 2006, patients that received major lower limb amputation in our department were enrolled in this study. Retrospective chart reviews concerning different factors that can affect the eventual postoperative functional status were investigated. Factors that affected the length of hospital stay included duration before amputation (P < 0.001) and renal function (P = 0.045). Phantom limb pain was affected by wound healing time (P = 0.006). Factors that affected the daily prosthesis usage time were initial infection status (P = 0.021), renal function (P = 0.01), patient educational level (P = 0.016), and pretraining waiting time (P = 0.003). The duration of prosthetic training was affected by patient educational level (P = 0.004) and marital status (P = 0.024). In addition, subjective satisfaction about the usage of prosthesis was affected by pretraining waiting time (P = 0.001) and daily prosthesis usage time (P < 0.001). The daily prosthesis usage time was closely related to life quality improvement (P < 0.001) and subjective satisfaction of prosthesis usage (P < 0.001). Despite reported unchangeable factors like age, end-stage renal disease, dementia, coronary artery disease, and level of amputation, preprosthesis training waiting time significantly affected the satisfaction and daily usage time of the prosthesis. Surgeons can make some contribution to accelerate amputation wound healing and stump maturation by choosing the correct operating procedure, delicately managing the soft tissue, and ascertaining proper wound care to improve the outcome.