Miracle-dz/UniFAR-FTUs huggingface dataset:
Proposing a new process model for mashup development by applying meta-design principles and goals for managing end user expectations

End users' requirements should be incorporated in the software, and service based ephemeral applications are no exception. Mashup development is facing different challenges such as inherent tension between the non-technical end user and complexity demands of the end user mashup development tools. We believe meta design can address these challenges. Meta design tends to provide a road map for innovative computational environments beyond the user-centered and participatory design. It seeks to bring the end user at the heart of software development by coining ideas such as co-designing at use-time, constant evolution of systems at the hand of users and Seeding, evolutionary growth and reseeding model (SER). There has been already some ideas generation regarding using meta-design principles for mashup development. We have further explored and assessed meta-design principles and have proposed a concrete solution in the form of a process model that can provide a way forward to overcome the predicaments faced by end users who wish to program for themselves at a comfortably abstract level in an evolutionary fashion. We present the process model and describe a motivational real-world scenario for validation purpose followed by initial observations of the experiment conducted.
Multiwatt, Continuous-Wave, Tunable Diamond Raman Laser With Intracavity Frequency-Doubling to the Visible Region

Multiwatt emission from a continuous-wave diamond Raman laser pumped within a diode-pumped InGaAs-based semiconductor disk laser (SDL) is reported. The Raman laser achieved a maximum output power of 4.4 W at 1228 nm with a beam quality factor (M2) of 1.4 and diode-to-Stokes conversion efficiency of 14.2%. Via tuning of the SDL oscillation wavelength, the diamond Raman laser was tuned from 1209 to 1256 nm, with output power exceeding 4 W over a 10-nm range. The evolution of the emission spectra and beam quality of both the SDL and the Raman laser have been investigated for different pump powers, revealing the onset of spectral broadening and beam “clean-up” effects with increasing power. The SDL spectral linewidth and beam overlap are then taken into account in calculations of the efficiency of the Raman laser. Using intracavity frequency-doubling in lithium triborate (LBO) within the Raman laser, up to 1.5-W output power at orange wavelengths was achieved with M2 <; 1.3 and linewidth ~0.1 nm full-width at half-maximum. Tuning of the visible emission was achieved via tuning of the SDL and temperature control of the LBO and covered the range 604.5-619.5 nm.
Changes in Serum Calcium, Phosphorus, and Magnesium Levels in Captive Ruminants Affected By Diet Manipulation

Abstract A combination of low serum calcium (Ca), high serum phosphorus (P), and low serum magnesium (Mg) has been observed in individual captive ruminants, primarily affecting kudu (Tragelaphus strepsiceros), eland (Taurotragus oryx), nyala (Tragelaphus angasii), bongo (Tragelaphus eurycerus), and giraffe (Giraffa camelopardalis). These mineral abnormalities have been associated with chronic laminitis, acute tetany, seizures, and death. Underlying rumen disease secondary to feeding highly fermentable carbohydrates was suspected to be contributing to the mineral deficiencies, and diet changes that decreased the amount of starch fed were implemented in 2003. Serum chemistry values from before and after the diet change were compared. The most notable improvement after the diet change was a decrease in mean serum P. Statistically significant decreases in mean serum P were observed for the kudu (102.1–66.4 ppm), eland (73.3–58.4 ppm), and bongo (92.1–64.2 ppm; P < 0.05). Although not statistically significant, mean serum P levels also decreased for nyala (99.3–86.8 ppm) and giraffe (82.6–68.7 ppm). Significant increases in mean serum Mg were also observed for kudu (15.9–17.9 ppm) and eland (17.1–19.7 ppm). A trend toward increased serum Mg was also observed in nyala, bongo, and giraffe after the diet change. No significant changes in mean serum Ca were observed in any of the five species evaluated, and Ca was within normal ranges for domestic ruminants. The mean Ca:P ratio increased to greater than one in every species after the diet change, with kudu, eland, and bongo showing a statistically significant change. The results of this study indicate that the diet change had a generally positive effect on serum P and Mg levels.
Long‐Term Kidney Isografts Develop Functional and Morphologic Changes That Mimic Those of Chronic Allograft Rejection

ObjectiveThis study examined antigen-independent factors in the pathogenesis of chronic rejection of organ transplants. Summary Background DataIn addition to alloantigen-dependent events, antigen-independent factors can influence chronic rejection of organ allografts. Initial injury, including early ischemia and acute rejection, may contribute. MethodsKidney isografts were transplanted orthotopically into bilaterally nephrectomized rat recipients and studied functionally, morphologically and immunohistologically, at serial intervals up to 72 weeks after transplantation. Controls included chronically rejecting kidney allografts using a well-established model, non-nephrectomized and uninephrectomized animals with a native kidney that had undergone initial ischemia and uninephrectomized rats whose remaining kidney had been manipulated operatively. ResultsAllograft recipients developed progressive proteinuria after 12 weeks, with gradual renal failure ultimately leading to death. At the same time, morphologic changes, including progressive arteriosclerosis and glomerulosclerosis, tubular atrophy, and interstitial fibrosis, developed. Immunohistologically, macrophages infiltrated glomeruli during this period and cytokines became upregulated. Comparable changes occurred in isografts, but later, beginning after week 24 and progressing thereafter. The single ischemic kidney in uninephrectomized controls also developed the same lesions; no comparable changes were noted in other control kidneys. ConclusionsAntigen-independent functional and morphologic changes occur in long-term kidney isografts that resemble those appearing considerably earlier in allografts that reject chronically. Initial injury and extent of functioning renal mass may be important factors for such late changes.
Clinico-haematological study in ailing pigeons of Nagpur city

In recent years a number of deaths of pigeons have been reported from different parts of the country, however causes have remained unknown. The present clinico-haematological investigation is an important criterion to derive data that can be used for disease control and reduce mortality in pigeons. Methods: The present study was undertaken during the year 2002 on the domestic pigeons Columbia livia reared in different parts of Nagpur city and data on area, number of birds infected, clinical symptoms, nature of infection, morbidity percentage were collected. The ailing birds were kept under observation and subjected to detail clinical investigation. Blood samples were collected from the wing vein. Blood smears and serum samples were collected and Hb%, PCV, DLC and TLC estimations were carried out. Results: A total of 1,166 pigeons were studied from different parts of the city, out of which 840 were found exhibiting signs of torticollis prominently accompanied with circling movement, drooping feathers, greenish watery diarrhoea and inability to peck grains. Some pigeons were exhibiting nervous signs like head shaking, muscular tremors, aiding movements, disorientation, incoordination and drooping of wings. In a few pigeons sneezing, nasal discharge and dullness were also observed. These observations corroborate with that reported by Barton et al. (1992) and Pennycott (1994). The morbidity and mortality rates were found to be 70.04 and 48.71 percent, respectively, though not statistically significant as far as total number of pigeons was concerned. These findings are supported by that of Afaleq et al. (1993), who reported that
Evaluation of circulating tumor cell (CTC) enumeration as an efficacy response biomarker of overall survival (OS) in metastatic castration-resistant prostate cancer (mCRPC): Planned final analysis (FA) of COU-AA-301, a randomized, double-blind, placebo-controlled, phase III study of abiraterone acet

LBA4517 Background: A preplanned interim analysis of COU-AA-301 showed that AA, a selective androgen biosynthesis (CYP17) inhibitor, significantly improves OS in mCRPC. This is the first phase III study to prospectively assess CTC as a surrogate biomarker as part of a regulatory qualification process, here using updated OS data. METHODS 1,195 patients (pts) with mCRPC post docetaxel were randomized 2:1 to AA (1 g QD) + P (5 mg BID) (n = 797) or placebo + P (n = 398). CTCs (screening and baseline [BL]; post BL at weeks 4, 8 and 12) were enumerated (cells/7.5 mL) at MSKCC and The ICR using CellSearch and analyzed with other prognostic covariates as dichotomous and continuous variables using updated OS data at 775 events (prior to crossover from placebo to AA). CTC (as part of a biomarker panel - LDH, PSA, Hg, AlkPhos) was examined as a surrogate for OS. Multivariate (Cox model) analyses were conducted. RESULTS At median follow up (FU) of 20.2 mo, the difference in median OS between the 2 groups improved from 3.9 to 4.6 mo (AA 15.8 mo vs placebo 11.2 mo; HR = 0.74; p < .0001). CTC counts were evaluated in 972 pts at screening and BL, 838 at 4 wks, 783 at 8 wks and 723 pts at 12 wks. High concordance between screening and BL values was observed (r = 0.83). CTC conversion using standard definition for unfavorable (CTC ≥ 5) and favorable (CTC < 5) counts was predictive of OS as early as 4 wks after treatment and its inclusion significantly reduced the treatment effect at all post-treatment time points (HR: from 0.74 to 0.97). A reduced model incorporating CTCs and LDH was developed. CONCLUSIONS The magnitude of the treatment effect of AA on OS increased with longer FU. Using standard definition of CTC conversion, the biomarker panel demonstrated a level of surrogacy for OS by correlating well with survival and in a model-adjusted analysis dramatically attenuating the treatment effect. BL CTCs and CTC conversion, along with LDH, were key predictors of OS. Future trials will further evaluate the CTC-based surrogate developed from COU-AA-301.
Estimation of the power electronic converter lifetime in fully rated converter wind turbine for onshore and offshore wind farms

A comparison has been made of the converter lifetime for a 3MW fully rated converter horizontal axis wind turbine located onshore and offshore. Simulated torque and speed of the turbine shaft were used to calculate voltage and current time series, that was used to calculate the junction temperatures of the diode and IGBT in the generator-side converter by a thermal-electrical model. A rainflow counting algorithm was applied to the junction temperature in combination with an empirical model of the lifetime estimation, to calculate the lifetime of the power electronic modules in the turbine. The number of parallel modules for each location to achieve 20 years life time has also been found. Simulations show the lifetime consumption rate of the diode and IGBT is decreased exponentially by increasing number of parallel modules, lowering the average temperature. The offshore wind turbine has a higher lifetime consumption rate, requiring a slightly higher converter rating to achieve a 20-year lifetime, but this difference is small, and both turbines will use the same number of modules.
MULTI-LEVEL SAMPLING APPROACH FOR CONTINOUS LOSS DETECTION USING ITERATIVE WINDOW AND STATISTICAL MODEL

This paper proposes a Multi-Level Sampling (MLS) approach for continuous Loss of Self-Similarity (LoSS) detection using iterative window. The method defines LoSS based on Second Order Self-Similarity (SOSS) statistical model. The Optimization Method (OM) is used to estimate self-similarity parameter since it is fast and more accurate in comparison with other estimation methods known in the literature. Probability of LoSS detection is introduced to measure continuous LoSS detection performance. The proposed method has been tested with real Internet traffic simulation dataset. The results demonstrate that normal traces have probability of LoSS detection below the threshold at all sampling levels. Meanwhile, false positive detection can occur where abnormal traces have probability of LoSS that imitates normal behavior at sampling levels below 100 ms. However, the LoSS probability exceeds the threshold at sampling levels larger than 100 ms. Our results show the possibility of detecting anomaly traffic behavior based on obtaining continuous LoSS detection monitoring.
Hierarchy or Activity? The Role of Formal and Informal Influence in Eliciting responses from Enterprise Social Networks

Social media makes fast inroads into corporate workplaces. Enterprise Social Networking (ESN) is associated with improved communication, information-sharing and has been argued to lead to more democratic communication patterns, whereby users increasingly derive authority from their contributions to the network rather than their position in the formal hierarchy. At the same time, this development remains largely un-explored empirically. Against this background, we explore the influence of both a user’s hierarchical level and level of communication activity on their ability to elicit responses from other ESN users. We draw on a unique data set of more than 110,000 messages collected from the ESN platform Yammer at Deloitte Australia. We confirm the existence of both kinds of influence, formal and informal, yet we show that communication activity has a much stronger effect than a user’s hierarchical position. We conclude that communication behaviour has a bigger influence on information diffusion than formal hierarchies. This points to the potentials of enterprise social networks in improving organic, user-driven communication and knowledge sharing within firms.
A qualitative exploration of the impact of a 12-week group exercise class for those moderately affected with multiple sclerosis

Purpose: The evidence base to support therapeutic exercise for people with multiple sclerosis (MS) is improving; however few studies have considered the patients’ perspective. This study aimed to explore the experiences and views of people moderately affected with MS following participation in a 12-week exercise programme. Method: Twenty people with MS participated in a group exercise class. Subsequently, four men and ten women took part in one of two focus groups. Semi-structured questions were used to elicit participants’ views on the exercise class, outcomes from exercise and the exercise class and any perceived facilitators or barriers to exercise. Data were analysed using a general inductive method. Results: Benefits to participating in exercise for those with MS included social support and symptom improvement. Psychosocial factors, symptoms and lack of service emerged as exercise barriers. Three inter-related themes emerged; (1) The exercise class developed as a bridge to allow participants to realise, (2) the benefits of the class, helping them to overcome and (3) barriers to exercise. Conclusion: Taking part in an exercise class was a positive experience for people with MS. Healthcare professionals should work with exercise professionals to provide feasible exercise opportunities to help those with MS benefit from therapeutic exercise. Implications for Rehabilitation People moderately affected with multiple sclerosis (MS) feel group exercise offers symptom improvement and social benefits. MS-related symptoms and a lack of service options may prevent those with MS exercising. Physiotherapists should work alongside exercise professionals to establish exercise services for those with MS.
Nicorandil Enhances Cardiac Endothelial Nitric Oxide Synthase Expression via Activation of Adenosine Triphosphate‐Sensitive K Channel in Rat

Summary: In the heart, nitric oxide activates an adenosine triphosphate (ATP)‐sensitive K (KATP) channel that is constructed of two subunits, i.e., an ATP‐binding cassette protein sulfonylurea receptor (SUR2) and a pore‐forming inward rectifier (Kir6.1 or 6.2). However, whether this KATP channel affects nitric oxide activation is unknown. Our aim was to assess whether pharmacologic activation of the KATP channel by nicorandil contributes to endothelial nitric oxide synthase (eNOS) levels. A total of 21 7‐week old male Sprague‐Dawley rats were used. Seven were treated by intraperitoneal injection of nicorandil at 3 mg/kg/d; seven were treated with intraperitoneal nicorandil at 3 mg/kg/d after glibenclamide at 12 mg/kg/d twice a day p.o. ; and seven were left untreated (controls). At 24 h after treatment, blood pressure and heart rate were measured, and eNOS, SUR2, Kir6.1, and Kir6.2 mRNA levels and eNOS protein levels in the left ventricle were determined by reverse transcription polymerase chain reaction (RT‐PCR) and Western blot analysis. Nicorandil caused tachycardia without a change in blood pressure, whereas glibenclamide had no effect on the nicorandil‐induced change in heart rate or on blood pressure. RT‐PCR revealed that nicorandil increased the eNOS and SUR2 mRNA levels by 2.2‐ and 2.0‐fold, respectively, (p < 0.01 versus control), and that these increases were completely inhibited by glibenclamide. A significant correlation was observed between eNOS and SUR2 mRNA levels in all experimental rats (r = 0.760, p < 0.001). However, Kir6.1 or 6.2 mRNA level was constant. Western blot analysis revealed that nicorandil caused a 1.6‐fold increase in eNOS protein levels (p < 0.01 versus control). This increase was completely inhibited by glibenclamide. In conclusion, upregulation of eNOS mRNA and protein levels by nicorandil, and inhibition of this upregulation by glibenclamide, were demonstrated in normotensive conscious rat hearts. Nicorandil appears to enhance cardiac eNOS expression via activation of a KATP channel.
Sulfide Binding by the Blood of the Hydrothermal Vent Tube Worm Riftia pachyptila

The blood of the deep-sea hydrothermal vent tube worm Riftia pachyptila Jones contains a sulfide-binding protein that appears to concentrate sulfide from the environment and may function for sulfide transport to the internal endosymbiotic bacteria contained within the coelomic organ, the trophosome.
Role of ovarian steroids in development of uterine binding sites for prolactin in the ferret.

The objectives of this study were to investigate 1) the presence of specific prolactin (PRL) binding sites in the ferret uterus, 2) the uterine location of 125I-labeled ovine PRL (oPRL) binding sites, 3) changes in uterine PRL binding sites during pseudo-pregnancy, and 4) regulation of PRL binding sites by ovarian steroids. Binding was determined through use of 125I-oPRL and 300-800 micrograms of protein from the 50,000 x g particulate fraction. Optimal binding occurred within 6 h at 25 degrees C. Scatchard analysis of saturation data revealed a single set of high-affinity (Kd = 4.99 x 10(-11) +/- 0.88 M), low-capacity (22.76 +/- 1.62 fmol/mg) binding sites. Analysis of hormonal specificity revealed that ovine growth hormone (oGH) cross-reacted with oPRL for the uterine binding sites, displacing 38% of the bound ligand. However, no inhibition of 125I-oPRL binding occurred in the presence of a 500-fold excess of bovine thyroid-stimulating hormone (bTSH), ovine LH (oLH), or ovine FSH (oFSH), suggesting hormonal specificity of the binding sites that are located in the luminal and glandular epithelium. Prolactin binding to ferret uterine membranes increased during the first half of pseudopregnancy, plateaued between Days 21 and 28, and then declined. The concentration of PRL binding sites in uteri of ferrets on Day 1 of pseudopregnancy was 4.91 +/- 0.42 fmol/mg of protein. (ABSTRACT TRUNCATED AT 250 WORDS)
Event‐related alpha oscillations are functionally associated with P300 during information processing

RECENT findings indicate that the electroencephalographic alpha (7–14 Hz) activity is functionally involved in cognitive brain functioning, but the issue of whether and how event-related alpha oscillations may relate to the processes indexed by the P300 component of the event-related brain potentials (ERPs) has not been addressed. The present study assessed the effect of auditory oddball task processing on slow (7–10 Hz) and fast (10–14 Hz) alpha activity from the P300 latency range. ERPs from mentally counted targets (20%) and uncounted non-targets (80%) were recorded at Fz, Cz, and Pz in nine subjects Single-sweep phase-locking, power of phase-locked, and power of non-phase-locked alpha responses during P300 activity were quantified. The results demonstrated that larger and more synchronized phase-locked fast alpha components at anterior (frontal-central) locations, with reduced non-phase-locked slow alpha responses at the parietal site were produced by targets relative to non-targets. Because the simultaneously recorded P300 and alpha activity manifested a similar sensitivity to the oddball task, event-related alpha appears to be functionally associated with the cognitive processing demands eliciting P300. Also, evidence is provided for the functional involvement of frontally synchronized and enhanced alpha oscillations in task processing.
A correlative study of ultrasound with serology in an area in China co‐endemic for human alveolar and cystic echinococcosis

We correlated ultrasound (US) imaging classifications for human alveolar echinococcosis (AE) and cystic echinococcosis (CE) with serology (ELISA and immunoblotting (IB) incorporating native and recombinant/purified echinococcal antigens) in community surveys (2001–2003) and follow‐up (2002 and 2003) of US‐confirmed cases in Ningxia, China. One hundred and seventy‐one cases (96 with AE, 75 with CE) were identified; of these, US classification and serological data were obtained for 142 and 112 cases, respectively. Seropositive‐rates increased in CE patients with highly viable unilocular cyst lesions (Types CL, CE 1 or CE 2) to degenerating primary lesions (CE 3), but then decreased in subjects with inactive (CE 4) or dead (CE 5) cysts. In contrast, there was a constant increase in seropositivity from the early (P1, P2) to the advanced stages (P3, P4) with AE cases. For US‐confirmed cases, follow‐up by US combined with serology is invaluable for studying the clinical progression of echinococcosis and for detecting recurrent cysts or reinfection post‐treatment.