Miracle-dz/UniFAR-FTUs huggingface dataset:
A 12-Year Anthropometric Evaluation of the Nose in Bilateral Cleft Lip–Cleft Palate Patients following Nasoalveolar Molding and Cutting Bilateral Cleft Lip and Nose Reconstruction

Background: Patients with bilateral cleft lip–cleft palate have nasal deformities including reduced nasal tip projection, widened ala base, and a deficient or absent columella. The authors compare the nasal morphology of patients treated with presurgical nasoalveolar molding followed by primary lip/nasal reconstruction with age-matched noncleft controls. Methods: A longitudinal, retrospective review of 77 nonsyndromic patients with bilateral cleft lip–cleft palate was performed. Nasal tip protrusion, alar base width, alar width, columella length, and columella width were measured at five time points spanning 12.5 years. A one-sample t test was used for statistical comparison to an age-matched noncleft population published by Farkas. Results: All five measurements demonstrated parallel, proportional growth in the treatment group relative to the noncleft group. The nasal tip protrusion, alar base width, alar width, columella length, and columella width were not statistically different from those of the noncleft, age-matched control group at age 12.5 years. The nasal tip protrusion also showed no difference in length at 7 and 12.5 years. The alar width and alar base width were significantly wider at the first four time points. Conclusions: This is the first study to describe nasal morphology following nasoalveolar molding and primary surgical repair in patients with bilateral cleft lip–cleft palate through the age of 12.5 years. In this investigation, the authors have shown that patients with bilateral cleft lip–cleft palate treated at their institution with nasoalveolar molding and primary nasal reconstruction, performed at the time of their lip repair, attained nearly normal nasal morphology through 12.5 years of age.
Delayed graft function is characterized by reduced functional mass measured by (99m)Technetium-mercaptoacetyltriglycine renography.

BACKGROUND The mechanism that underlies delayed graft function (DGF) is still poorly defined. Previous studies using tubular function tests have shown that postischemic injury to the renal transplants results in profound impairment of paraimmunohippurate (PAH) extraction through the tubules. METHODS Using (99m)Technetium-mercaptoacetyltriglycine ((99m)Tc-MAG3) renography and tubular function slope (TFS), a study of the tubular uptake of (99m)Tc-MAG3 was undertaken in a prospective study of renal transplant recipients with immediate graft function (IGF) and those with DGF. RESULTS A total of 37 consecutive recipients of a cadaveric graft and 5 kidneys from living donors was evaluated within 48 hours after transplantation and in week 2, months 3 and 6, and 3 years after transplantation. In addition to the protocol scans, recipients with DGF were examined every other day until function was resumed. Repeated measurement two-way analysis of variance and a change point analysis were performed to determine the difference in the follow-up of TFS values between the two groups. Fourteen patients were classified as having DGF and 28 immediate graft function. In the DGF group, the initial TFS value was significantly lower than in the immediate graft function group (0.54 [+/-0.01] and 1.75 [+/-0.16], respectively; P=0.002), a difference that persisted for up to 3 years. Change point analysis revealed that the postischemic tubular excretion improved with time in both groups in the first 3 to 4 weeks, but both groups remained different up to 3 years after transplantation. Multivariate analysis revealed that only the cold ischemic time was an independent risk factor for a low TFS value. After the initial recovery from postischemic injury, the TFS may be used as a marker for functional renal mass. CONCLUSION We propose that the tubular defect in DGF, as defined by (99m)Tc-MAG3 renography, is irreversible and may be a marker of initial graft function.
Analysis of the radiation efficiency of a horizontal electric dipole on a grounded dielectric slab

The radiation efficiency of a horizontal infinitesimal electric dipole on a grounded dielectric slab as a function of its electrical thickness is investigated thoroughly. It is shown that, in contrast to a common belief, the efficiency does not decay monotonically with increasing electrical thickness (or, equivalently, with increasing frequency for a given slab), but oscillates in correlation with the onset of surface waves. Specifically, the efficiency maxima and minima are shown to occur at the cutoff frequencies of the TE and TM surface-wave modes, respectively (excluding the cutoff-less TM0 mode), using a spectral transmission line analysis in conjunction with a simple auxiliary dipole collocated with the source. From this auxiliary dipole, the efficiency maxima and minima are essentially explained in terms of equivalent PMC and PEC walls at the position of the source. To the best of our knowledge, this is the first complete explanation of the oscillatory behavior of the efficiency of a dipole on a grounded substrate. The finding has a fundamental implication for electrically thick planar antennas, which include most millimeter-wave antennas: such antennas may be specifically designed to exhibit their operation frequency at a local maximum of the efficiency even if the substrate is electrically very thick.
Cochlear Implantation Versus Auditory Brainstem Implantation in Bilateral Total Deafness After Head Trauma: Personal Experience and Review of the Literature

Objective To determine the effectiveness of cochlear implant (CI) in hearing restoration after temporal bone (TB) fractures and investigate the adequacy of auditory brainstem implant (ABI) indication for TB fractures. Study Design Retrospective clinical study; a systematic review of the literature in PubMed was also performed to identify all published cases of bilateral TB fractures or bilateral deafness after head trauma treated by means of CI or ABI. Settings Quaternary otology and skull base surgery referral center. Patients Eleven consecutive patients presented with bilateral severe-to-profound sensorineural hearing loss after head trauma. Interventions CI as primary intervention or following a previous treatment. Main Outcome Measures CI performances were evaluated in the auditory-only condition in both closed-set and open-set formats. Results Fourteen CI were placed, 11 as primary treatment and 3 after ABI failure. At the last follow-up, all patients gained useful open-set speech perception. In secondary CI, all patients obtained better auditory results with the CI if compared with ABI. CI performance did not decrease with time in any case. Conclusion Cochlear implantation after TB fractures has proved to have excellent audiometric results. The aim of the initial evaluation of a patient with bilateral anacoustic ears from head trauma should always be to rehabilitate their hearing with a CI. The incidence of labyrinthitis ossificans, negative electrophysiologic testing, the risk of postoperative meningitis or facial nerve stimulation should not be the determinant factors that favor ABI placement.
Ten-Year Evaluation of Cementless Buechel-Pappas Meniscal Bearing Total Ankle Replacement

A porous-coated, cementless, congruent-contact, three-piece, meniscal-bearing total ankle replacement was developed and used clinically over a 2- to 10-year period for patients with disabling ankle arthritis. Polished titanium-nitride ceramic-coated Ti6Al4V tibial and talar components with a deep-sulcus trochlear groove and two lateral fixation fins for the talar onlay component were used. The ultra-high-molecular-weight polyethylene (UHMWPe) meniscal bearing congruently conformed to the flat upper tibial component surface and the deep sulcus and cylindrical geometry of the lower talar component surface. Fifty deep-sulcus (Buechel-Pappas™) total ankle replacements were implanted in 49 patients. Diagnoses were 8 osteoarthritis (16%), 7 rheumatoid arthritis (14%), 2 avascular necrosis (4%), and 33 post-traumatic arthritis (66%). Ages ranged from 26 to 71 years (mean 49 years). Clinical results using a strict ankle scoring system demonstrated good/excellent results in 88% of cases. Postoperative ankle motion ranged from 12° to 46° total arc (mean 28°), which was similar to the preoperative motion. Revision for malalignment was necessary in two cases (4%). Mechanical complications included one case of meniscal bearing wear (2%) in a patient with posttraumatic arthritis with component malalignment and one case of talar component subsidence (2%) in a patient with avascular necrosis of the talus. No tibial component loosening was seen. Cumulative survivorship using an end point of revision of any component for any reason was 93.5% at 10 years (confidence interval 61–100%).
Does postpartum depression predict emotional and cognitive difficulties in 11 year olds

This paper examines the role of postpartum depression (PPD) on the emotional and cognitive development of 11-year olds, a key stage of transition in child development before entering adolescence. The present study uses data from the MCS, a longitudinal cohort study with a large and representative sample of the UK population. The results show that PPD impacts on child emotional difficulties when these are reported by the mother or the teacher; child-reported measures of emotional problems do not show any correlation with PPD Cognitive ability tests show no association between PPD and childrenâ€™s cognitive performance at age 11. The results of the paper have enhanced our insight regarding a significant period of transition which has not previously been the focus of research and demonstrate the impact PPD has on childrenâ€™s emotional development.
Acute Hemodynamic Effects of Methoxamine in Man

The circulatory effects of single intravenous injections of 0.065 mg. /kg methoxamine were investigated in 5 healthy volunteer subjects. Ninety minutes after the first injection, atropine 1–2 mg. was administered intravenously and the injection of methoxamine repeated. Cardiovascular parameters were evaluated by ballistocardiographic and dye-dilution methods, the former data continuously calculated by an analog computer. Methoxamine briefly, but markedly, depressed heart rate, cardiac output, and left ventricular work. Stroke volume decreased moderately, while mean arterial pressure increased moderately, and total peripheral resistance increased markedly. A preliminary partial vagal block with atropine permitted a greater increase in mean arterial pressure, with lesser changes in all other parameters except stroke volume, thus making methoxamine a “better” vasopressor.It is suggested that some of the depressant effects of methoxamine are related to intense arteriolar constriction, venous pooling of blood, reflex vagal depression of the atria and ventricles, and direct beta-adrenergic blocking, and excitation-contraction uncoupling actions.
Automated Detection of Substance Use-Related Social Media Posts Based on Image and Text Analysis

Nowadays, teens and young adults spend a significant amount of time on social media. According to the national survey of American attitudes on substance abuse, American teens who spend time on social media sites are at increased risk of smoking, drinking and illicit drug use. Reducing teens’ exposure to substance use-related social media posts may help minimize their risk of future substance use and addiction. In this paper, we present a method for automated detection of substance userelated social media posts. With this technology, substance userelated content can be automatically filtered out from social media. To detect substance use related social media posts, we employ the state-of-the-art social media analytics that combines Neural Network-based image and text processing technologies. Our evaluation results demonstrate that image features derived using Convolutional Neural Network and textual features derived using neural document embedding are effective in identifying substance use-related social media posts.
Analysis of WiMAX Radio Measurements and Comparison With Some Models Over Dense Urban Western India at 2.3 GHz

Propagation characteristics in the 2.3-GHz band were studied in a dense urban environment. Experiments at this frequency using WiMAX transmissions were conducted in dense urban western India. Coverage predictions using various models and their comparison with measured data were carried out. Path-loss exponents, mean errors, and standard deviations of all the prediction methods were deduced, and suitable models for the path-loss prediction identified.
Autonomic nervous dysfunction in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA): possible pathogenic role of autoantibodies to autonomic nervous structures

Autonomic nervous dysfunction has been previously reported in SLE, RA and systemic sclerosis, but the pathogenesis of such a complication is poorly understood. In the present study, four standard cardiovascular autonomic function tests were performed in 34 female patients with connective tissue diseases and in 25 healthy control subjects, and results expressed as cardiovascular (CV) test scores. Moreover, in each subject the presence of circulating complement‐fixing autoantibodies directed against sympathetic and parasympathetic nervous structures, represented by superior cervical ganglia and vagus nerve, respectively, was simultaneously assessed by an indirect immunofluorescent complement‐fixation technique, using rabbit tissue as substrate. None of the patients reported autonomic symptoms. However, an abnormal CV test score (≥ 5) was detected in 15% of the patients and in none of the healthy control subjects, approaching statistical significance (P = 0.07). No correlation was found between CV test results and disease duration, type of therapy or presence of conventional autoantibodies. One or two autoantibodies to autonomic nervous structures were detected in six patients (18%) and not in the control subjects (P < 0.05). Values of deep breathing test were significantly lower in autoantibody‐positive patients compared with those amongst the control subjects (P < 0.05), and an abnormal CV test score was significantly associated with the presence of autoantibodies to autonomic nervous structures (P < 0.05). In conclusion, we confirm that autonomic nervous function can be impaired in patients with connective tissue diseases, and suggest that autoantibodies directed against autonomic nervous system structures may play a role in the pathogenesis of the autonomic dysfunction.
The acute effects of vibration training on balance and stability amongst soccer players

Abstract Acute whole body vibration training (WBVT) is a tool used amongst coaches to improve performance prior to activity. Its effects on other fitness components, such as balance and stability, along with how different populations respond are less well understood. The aim of the current research is to determine the effect of acute WBVT on balance and stability amongst elite and amateur soccer players. Forty-four healthy male soccer players (22 elite and 22 amateur) were assigned to a treatment or control group. The intervention group then performed 3 × 60 seconds static squat on vibration platform at 40 Hz (±4 mm) with Y balance test (YBT) scores and dynamic postural stability index (DPSI) measured pre and post. DPSI was significantly lower in the elite players in the acute WBVT compared to amateur players (F1, 40= 6.80; P = 0.013). YBT anterior reach distance showed a significant improvement in both amateur and elite players in the acute WBVT group (F1, 40= 32.36; P < 0.001). The improvement in DPSI amongst the elite players indicates a difference in responses to acute high frequency vibration between elite and amateur players during a landing stability task. The results indicate that acute WBVT improves anterior YBT reach distances through a possible improvement in flexibility amongst both elite and amateur players. In conclusion, acute WBVT training appears to improve stability amongst elite soccer players in comparison to amateur players, the exact reasoning behind this difference requires further investigation.
Redundant Data in the Meta-analysis on Helicobacter pylori Eradication

TO THE EDITOR: We read with interest the recent meta-analysis by Fuccio and colleagues (1). There is an ongoing Cochrane review on this subject; its protocol is published (2), and its results have been reported in abstract form (3). Fuccio and colleagues report that eradication therapy for Helicobacter pylori reduces the subsequent incidence of gastric cancer. However, we have serious doubts about the accuracy of their analysis. In the Methods section of their article, Fuccio and colleagues state that when they found multiple articles for a single study, they used the latest publication from each eligible study. However, the meta-analysis erroneously incorporated data from the same randomized, controlled trial (RCT) twice (4, 5). Tables 1 and 2 (1) showed 2 studies that were conducted in the Shandong province of China, commenced in 1996, had very similar numbers of participants, and used identical eradication regimens of the same duration. We contacted the original investigators of these studies (2, 3) directly when collecting data for our review. Those investigators confirmed that the 2 publications were in fact 5-year (4) and 10-year (5) follow-up studies from the same RCT. The erroneous inclusion of repeated data led Fuccio and colleagues to report a statistically significant effect of H. pylori eradication therapy in reducing incidence of gastric cancer, when this is not the case. If only the 10-year follow-up data are included (5), the pooled relative risk for subsequent gastric cancer is 0.65 (95% CI, 0.42 to 1.01). Also, the pertinent trial publications reported fewer cases of gastric cancer after 10-year follow-up (5) than at 5-year follow-up (4), raising concerns about the accuracy of data collection or of reporting for the trial. Taken together, this information convinces us that the effect of eradication therapy on gastric cancer is not as clear-cut as Fuccio and colleagues suggest. We delayed publishing our full Cochrane review because of these concerns about the duplicate Chinese studies. Our knowledge and experience regarding errors in meta-analyses and the fact that Annals published the meta-analysis with erroneous data highlight several important issues for authors of meta-analyses, for journal editors, and for peer reviewers. First, transparent reporting of follow-up studies conducted at various time points from the same RCT is needed to ensure correct identification of trials and to avoid miscounting of data by authors. Second, when studies are reported only in abstract form, or if the accuracy of the data is in doubt, authors should directly contact original investigators for clarifications. Finally, peer reviewers (and journal editors) may have difficulty confirming the results of systematic reviews and meta-analyses. In some cases, independent verification of the meta-analysis may be needed to ensure the results are truly accurate.
The mediating role of self‐criticism and dependency in the association between perceptions of maternal caring and depressive symptoms

Background: This study examined a theoretically based mediation model including participants' perceptions of early relationships with their mother, self‐criticism, dependency, and current depressive symptoms. We expect that (a) early relationships characterized by low levels of care and high levels of overprotection will be positively associated with both current depressive state and self‐criticism and dependency; (b) high levels of self‐criticism and dependency will be positively associated with depressive symptoms; and (c) self‐criticism and dependency will play a mediating role in the association between participants' perceptions of early relationships characterized by low levels of care and high levels of overprotection and their current depressive symptoms. Methods: A nonclinical community sample of 200 Portuguese adults participated in the study. Perceptions of early relationships were measured using the mother scales of the Parental Bonding Instrument (Parker et al. [1979: Br J Med Psychol 52:1–10]), levels of self‐criticism and dependency were measured using the Depressive Experiences Questionnaire (Blatt et al. [1976: J Abn Psy 6:383‐389]), and depressive symptoms were measured using the Center for the Epidemiological Studies of Depression Scale (Radloff [1977: Appl Psychol Meas 1:385–401]. Results: Structural equation modeling showed that the link between participants' perceptions of early caretaking relationships with their mothers and their current depressive symptoms is mediated by high levels of self‐criticism—a personality trait associated with vulnerability to depression—but not Dependency. However, an ancillary analysis indicated that the link between participants' perceptions of early maternal overprotective relationships and their current depressive symptoms is mediated by high levels of Neediness. Conclusions: Findings underscore the role of perceived early relationships in psychological vulnerability to depression among highly self‐critical and among highly needy individuals and highlight the negative role played by perceived mothers' early dysfunctional practices, characterized by low levels of caring and high levels of overprotection, for the self‐critical vulnerability to depression and by perceived mothers' high levels of overprotection, for the neediness vulnerability to depression. These potential causal mechanisms warrant longitudinal evaluation. Theoretical and clinical implications of the findings are discussed. Depression and Anxiety, 2010. © 2010 Wiley‐Liss, Inc.
Heterosexual transmission of hepatitis C virus in family groups without risk factors.

alternative to transfusion of allogeneic blood. The cost of producing a unit of autologous blood in our centre is currently about twice the cost of an equivalent allogeneic unit. This difference is due to the staffing and transport costs of the autologous clinics, which are located at several hospitals within the region to allow easy access for patients. If the programme were to expand, allowing venesection of more donors at each clinic, the collection cost per unit would fall. Unused autologous units were not made available for any other recipient. Most of our autologous donors were taking drugs which would make their blood donation unacceptable for allogeneic use. Also, most autologous units were transfused, those not transfused being held for potential autologous use until expiry or patient discharge. Thus very few units would ultimately be suitable for crossover and procedures for their retrieval are not justified. We have shown the feasibility of a regional autologous donation programme coordinated by a blood transfusion centre. Main factors which prevented autologous donation were failure to attend the clinic, anaemia, and cardiovascular disease. The main factors which restricted the provision of blood by those who donated were late referral and post-donation anaemia. The aim of avoiding allogeneic blood transfusion was achieved by most patients who donated blood.