Miracle-dz/UniFAR-FTUs huggingface dataset:
Acquired antithrombin III deficiency secondary to asparaginase therapy in childhood acute lymphoblastic leukaemia

As improved treatment regimens for acute lymphoblastic leukaemia (ALL) continue to improve survival future, therapy must also take into consideration the many secondary problems. Most of these are the direct result of combination chemotherapy and l-asparaginase (ASP), is an example of a highly effective chemotherapeutic agent with serious side-effects such as thromboembolic events. ASP interferes with protein synthesis resulting in an acquired deficiency of antithrombin III. This review explores the effects of ALL and ASP on haemostasis, and the link between ASP and thromboembolic events in childhood ALL.
Death decoy receptor overexpression and increased malignancy risk in colorectal cancer.

AIM To evaluate human epidermal growth factor receptor 2 (HER2) and death decoy receptor (DcR3) as colorectal cancer prognostic indicators. METHODS Colorectal carcinoma specimens from 300 patients were analyzed by immunohistochemistry to detect the staining patterns of HER2 and DcR3. Classification of HER2 staining was carried out using the United States Food and Drug Administration semi-quantitative scoring system, with scores of 0 or 1+ indicating a tumor-negative (normal expression) status and scores of 2+ and 3+ indicating a tumor-positive (overexpression) status. Classification of DcR3 was carried out by quantitating the percentage of positive cells within the stained section, with < 10% indicating a tumor-negative status and ≥ 10% indicating a tumor-positive status. Correlation of the HER2 and DcR3 staining status with clinicopathological parameters [age, sex, tumor size, differentiation, and the tumor, node, metastasis (pTNM) classification] and survival was statistically assessed. RESULTS Tumor-positive status for HER2 and DcR3 was found in 18.33% and 58.33% of the 300 colorectal carcinoma specimens, respectively. HER2 tumor-positive status showed a significant correlation with tumor size (P = 0.003) but not with other clinicopathological parameters. DcR3 tumor-positive status showed a significant correlation with tumor differentiation (P < 0.001), pTNM stage (P < 0.001), and lymph node metastasis (P < 0.001). However, correlation coefficient analysis did not indicate that a statistically significant correlation exists between tumor-positive status for the HER2 and DcR3 overexpression (P = 0.236). Patients with specimens classified as DcR3-overexpressing had a significantly worse overall survival (OS) rate than those without DcR3 overexpression (median OS: 42.11 vs 61.21 mo; HR = 50.27, 95%CI: 44.90-55.64, P < 0.001). HER2 overexpression had no significant impact on median OS (35.10 mo vs 45.25 mo; HR = 44.40, 95%CI: 39.32-49.48, P = 0.344). However, patients with specimens classified as both HER2- and DcR3-overexpressing had a significantly poorer median OS than those with only HER2 overexpression (31.80 mo vs 52.20 mo; HR = 35.10, 95%CI: 22.04-48.16, P = 0.006). CONCLUSION HER2 overexpression is not an independent prognostic marker of colorectal cancer, but DcR3 overexpression is highly correlated with lymph node metastasis and poor OS.
Atoms, molecules, solids, and surfaces: Applications of the generalized gradient approximation for exchange and correlation.

Generalized gradient approximations (GGA's) seek to improve upon the accuracy of the local-spin-density (LSD) approximation in electronic-structure calculations. Perdew and Wang have developed a GGA based on real-space cutoff of the spurious long-range components of the second-order gradient expansion for the exchange-correlation hole. We have found that this density functional performs well in numerical tests for a variety of systems: (1) Total energies of 30 atoms are highly accurate. (2) Ionization energies and electron affinities are improved in a statistical sense, although significant interconfigurational and interterm errors remain. (3) Accurate atomization energies are found for seven hydrocarbon molecules, with a rms error per bond of 0.1 eV, compared with 0.7 eV for the LSD approximation and 2.4 eV for the Hartree-Fock approximation. (4) For atoms and molecules, there is a cancellation of error between density functionals for exchange and correlation, which is most striking whenever the Hartree-Fock result is furthest from experiment. (5) The surprising LSD underestimation of the lattice constants of Li and Na by 3--4 % is corrected, and the magnetic ground state of solid Fe is restored. (6) The work function, surface energy (neglecting the long-range contribution), and curvature energy of a metallic surface are all slightly reduced in comparison with LSD. Taking account of the positive long-range contribution, we find surface and curvature energies in good agreement with experimental or exact values. Finally, a way is found to visualize and understand the nonlocality of exchange and correlation, its origins, and its physical effects.
Thermal-aware device design of nanoscale bulk/SOI FinFETs: Suppression of operation temperature and its variability

The self-heating effects in Bulk/SOI FinFETs have been systematically investigated and compared. It is demonstrated that lattice temperature is significantly lower in Bulk FinFETs owing to the larger heat dissipation to the Si substrate. Heat dissipation paths in Bulk/SOI FinFETs have been studied and the device-parameter dependence of thermal characteristics has been analyzed. It is demonstrated that the Bulk FinFETs show greater temperature fluctuations resulting from device parameter variations. The fluctuation can be greatly suppressed by miniaturizing the extension length. It is shown that the impact of thermal resistance at the MOS interface is more significant in SOI FinFETs than in Bulk FinFETs.
Association between mental health status and sleep status among adolescents in Japan: a nationwide cross-sectional survey.

OBJECTIVE Previous epidemiological studies on relationships between mental health status and sleep status of adolescents have not been sufficiently representative. In the present study, using samples representative of Japanese adolescents nationwide, associations between mental health status and various sleep statuses were examined. METHOD The survey was conducted in December 2004 and January 2005 among students enrolled in randomly selected junior and senior high schools throughout Japan, using self-administered questionnaires that addressed lifestyle, sleep status, mental health status, and personal data. Of 103,650 questionnaires collected, 99,668 were analyzed. Sleep status was assessed according to sleep duration, subjective sleep assessment, bedtime, and insomnia symptoms. The Japanese version of the 12-item General Health Questionnaire was employed for assessment of mental health status. RESULTS Mental health status of subjects whose sleep duration was less than 7 hours, and those who slept 9 hours or more, was poorer than that of subjects who slept for 7 hours or more but less than 9 hours. A U-shaped association was observed between mental health status and sleep duration. Furthermore, a linear association was observed between subjective sleep assessment and mental health status; the worse the subjective sleep assessment, the poorer the mental health status. Mental health status was also inversely proportional to the frequency of insomnia symptoms. CONCLUSION The fact that sleep duration and subjective sleep assessment showed different patterns of association with mental health status indicates that these 2 sleep parameters have independent significance. Considering these associations, it is important to promote mental health care and sleep hygiene education for adolescents.
Glomerular Structure in Nonproteinuric IDDM Patients With Various Levels of Albuminuria

Although microalbuminuria is known to foretell the later development of overt proteinuria in patients with insulindependent diabetes mellitus (IDDM), different investigators have reported different levels of albuminuria as being predictive. However, whether different levels of albuminuria reflect differences in glomerular structure is not well known. In this study, we divided a cohort of 66 nonproteinuric long-standing (duration 20 ± 7 years) IDDM patients, who had both renal functional and structural studies performed, into four groups according to their urinary albumin excretion rate (AER). The several different levels of microalbuminuria previously reported to be predictive served to demarcate these groups: group I, AER ≤22 mg/24 h (upper limit for normal in our laboratory) (33 patients); group II, AER 23–45 mg/24 h (11 patients); group HI, AER 46–100 mg/24 h (13 patients); and group IV, AER 101–220 mg/24 h (9 patients). Creatinine clearance was similar in groups I, II, and III but was lower in group IV. Systemic hypertension was present in five patients in group I, one in group II, seven in group III, and five in group IV. Mean values for glomerular basement membrane (GBM) width and volume fraction of the mesangium [Vv(mes/glom)] were greater in all groups than in a group of 52 age-matched normal kidney donors (P < 0.0001). Also, filtration surface density [Sv(PGBM)], inversely related to Vv(mes/glom) (r = 0.61, P < 0.0001), was reduced in all diabetic groups compared with the normal group (P < 0.0001). Structural measures were identical in group I and II. GBM width, Vv(mes/ glom), and Sv(PGBM) were more abnormal in groups III and IV than either group I or II (P < 0.05). Hypertension was unrelated to the values for any of these structural measures. However, AER and blood pressure had an interactive effect on Vv(mes/glom) (P = 0.002); in patients with AER <45 mg/24 h and hypertension, Vv(mes/ glom) was higher than in normotensive patients in the same AER category (P < 0.03). Thus, morphometric measures characteristic of diabetic glomerulopathy are present in normoalbuminuric IDDM patients, albeit in some of these patients renal structure is in the normal range. Lesions, on average, are more advanced when albuminuria exceeds 45 mg/24 h. In patients with AER >45 but <220 mg/24 h, a further division based on AER (< and >100) does not discriminate groups with different glomerular lesions. Therefore, albuminuria >45 mg/24 h indicates more advanced diabetic glomerulopathy and is frequently associated with other functional abnormalities such as reduced glomerular filtration rate and increasing blood pressure. These results are consistent with the majority of studies that have found the higher ranges of microalbuminuria to predict progression to overt nephropathy with greater specificity.
Mood and Flexibility in Categorization: A Conceptual Replication

The present study tested the hypothesis that positive mood facilitates cognitive flexibility in categorization, i.e., positive mood enhances the ability to categorize flexibly at broad and narrow levels contingent on task requirement. The study was a conceptual replication of the 1990 work by Murray, Sujan, Hirt, and Sujan. Unlike the original study, it was carried out on the WWW with some modifications in the procedure. Participants were 29 women and 132 men whose average age was 29 yr. They were put into a positive, negative, or neutral mood using the Velten technique. Mood was measured with standard mood scales. Subjects then listed similarities or differences between two entertainment TV shows. Contrary to the prediction, participants in a positive mood did not list a higher number, more diverse, or more unusual similarities and differences between the shows, and they were not faster than participants with neutral or negative moods. It is concluded that the influence of mood on cognitive flexibility needs to be reconsidered In research, temporal aspects of categorization performance as well as a wider range of mood valences should be taken into account.
A Systematic Review on the Effects of Personalized Price Promotions for Food Products

ABSTRACT Recent decades have witnessed the increasing adoption of personalized price promotion (PPP) at grocery stores. Despite the growing body of research debating whether PPP is more effective than untargeted price promotions, there is no literature synthesizing the relevant evidence on food products. Therefore, we conduct a systematic review to examine empirical findings on the effects of PPP targeting food products. Outcomes of 12 identified studies demonstrate larger sales and profit boosting effects of PPP than its non-personalized counterparts. Meanwhile, the results on how this approach influences consumer behavior are mixed. The effectiveness of PPP varies among different targeting strategies (e.g. reward or cross-selling) and information collection methods (e.g. using within- or across-chain data). The findings of this review have important managerial implications for the future evaluation and application of PPP as well as imply potential directions of further research on this topic.
Antioxidant and histopathological effect of catechin and neem leaves extract in acrylamide toxicity of rats. By

Recently, considerable alteration has been focused on dietary and medicinal photochemical that inhibit reveres or retard damage caused by oxidative and inflammatory processes. Catechin and neem leaves extract have both antioxidant and anti-inflammatory properties. In the present study we investigated wither catechin and neem extract can reduce the toxic effects of acrylamide. Acrylamide (2.8mM), catechin 1.5%, neem leave extract (200 mg/kg body wt), acrylamide + catechin and acrylamide + neem leave extract were given to rats. Catechin and neem leaves extract partially protects hemogram from anemia and leucopenia caused by Acrylamide treatment. In addition, these photochemical significantly modulated the lipid peroxidase (TBARS) associated with a reduction of GSH (reduced glutathione) and catalase enzyme observed in acrylamide groups. The microscopic examination of different organs in rats received acrylamide revealed a variable damage of tissues. The intensity of these changes were decline with a nearly degree in rats received catechin or neem leaves extract.
MEASURE THEORY AND HILBERT’S TENTH PROBLEM INSIDE ℚ

For a ring R, Hilbert’s Tenth Problem HTP(R) is the set of polynomial equations over R, in several variables, with solutions in R. When R = Z, it is known that the jump Z′ is Turing-reducible to HTP(Z). We consider computability of HTP(R) for subrings R of the rationals. Applying measure theory to these subrings, which naturally form a measure space, relates their sets HTP(R) to the set HTP(Q), whose decidability remains an open question. We raise the question of the measure of the topological boundary of the solution set of a polynomial within this space, and show that if these boundaries all have measure 0, then for each individual oracle Turing machine Φ, the reduction R′ = ΦHTP(R) fails on a set of subrings R of positive measure. That is, no Turing reduction of the jump R′ of a subring R to HTP(R) holds uniformly on a set of measure 1.
Analisis Pengaruh Car, Npl, Nim, Bopo Dan Ldr Terhadap Roe Pada Bank Umum Swasta Nasional Devisa Di Indonesia

This research is meant to find out the influence of Capital Adequacy Ratio (CAR), Non Performing Loan (NPL), Net Interest Margin (NIM), Biaya Operasional/Pendapatan Operasional (BOPO), and Loan to Deposit Ratio (LDR) to the Return on Equity (ROE) at Private Foreign Exchange National Bank in Indonesia. The population is all Private Foreign Exchange National Bank in Indonesia. This study has been done by using purposive sampling method with two criteria so 20 companies have been selected as samples. The analysis technique has been done by using multiple linear regressions. The results showed that CAR, NIM, and LDR did not effect to ROE, whereas NPL and BOPO has negative effect to ROE. Where it was proved that together CAR, NPL, NIM, BOPO, and LDR have influence to ROE. Management should improve the company’s financial performance, especially on the non performing loan and operational efficiency of the business so that the company can improve to ROE
A Study of the Personal Information Management practices of Librarians

Research Problem: Personal Information Management is an increasingly important subject as more and more of people’s work becomes information-based. Understanding the information management practices of information professionals both as a group and in individual sectors has been the focus of several investigations, but there is limited research focusing on librarians, although they are often the major interface between information professionals and other people. This study aims to discover how librarians practice work-related Personal Information Management and how they adapt to the constant changes in information technology. Methodology: An exploratory qualitative study using data gathered from semi-structured interviews with librarians conducted in their own workspaces similar to those used in several other exploratory PIM studies, and analysed with grounded theory methods. The participants were selected from among librarians working in various branches of Auckland Libraries, who responded to a call for participants sent out in internal mailing lists. Results: The study found that librarians have broad skills in the realm of personal information management, with many techniques found to deal with common problems in PIM such as information fragmentation. However, librarians’ strong personal skills and ability to organise their own information leads to their information regularly being difficult to find for other librarians, as many use their own idiosyncratic structures even within shared systems. Implications: The results suggest that librarians’ ability to share information among themselves within an organisation could be improved by reducing the individual quirks of their organisation systems and increasing standardisation, if they can be convinced to use it.
Reducing Plastic Bag Use in Indonesia

How can plastic bag use in Indonesia be reduced? This dissertation attempts to answer this question applying two approaches: (1) Utilizing qualitative and quantitative research to investigate crucial factors explaining plastic bag use; (2) Conducting natural field experiments to identify effective behavioral interventions reducing the use of plastic bags in Indonesia. The pollution of the oceans by plastic waste is a growing threat to marine life, ecosystems, livelihoods of coastal communities and the health of human beings in general. Indonesia is the world’s second largest source of marine plastic pollution. Regulations and policies have shown to be effective in the reduction of the use of and pollution by plastic bags in a number of countries. But for the Indonesian Government and many other governments the feasibility of implementing and enforcing such measures is limited. Given this situation, there is an urgent need to investigate and find effective alternative approaches to reduce plastic bag use. Such alternative approaches include non-governmental organizations, environmental groups and social enterprises. This research aims to explain plastic bag use with the help of research methods from cultural anthropology. Qualitative and quantitative methods were applied along with different types of triangulation to examine people’s concepts of nature, the perceived benefits and disadvantages of plastic bag use, and promising local initiatives. To find effective behavioral interventions for reducing plastic bag use we conducted natural field experiments. These tested normative and economic interventions in combination with ecofriendly reusable shopping bags. Specific interventions ranged from social norms and different societal authorities to indirect monetary incentives and bonus schemes. In this context we also analyzed socio-economic factors and environmental awareness in relation to frequency of plastic bag use.
Two techniques used to improve the efficiency of existing PV panels: Thermal management & PERC technology

Current solar panels can be improved using several techniques that boost the efficiency and cell performance. Looking in the latest studies currently on-going in the laboratories, two main fields were mostly taking a considerable success: PERC technology and passive thermal management. PERC technology involves the addition of a dielectric passivation layer to the already existing layers in the p-type crystalline wafers. This helps trap more sunlight and generate more electricity, thus improving the crystalline silicon panel. In addition, proper thermal management of photovoltaics leads to better heat dissipation, which improves the conversion of sunlight to electricity and maintains a stable panel performance in the long run.
An Insight into Current IoT Security Methods

This paper examines the security methods in the Internet-of-Things. The security methods are carefully studied and categorized into six layers according to the Internet-ofThings framework namely Event Producer and Consumer, Event Queuing System, Transformation and Analysis, Storage, Presentation and Action, and Users and Systems. It can be observed that most security methods emphasizes on Event Producer and Consumer layer whereas the least focused layer is Users and Systems layer. This study aims to present a comprehensive overview to researchers working in the domain of the Internet-of-Things security.
PENGARUH PENERAPAN AKUNTANSI UMKM TERHADAP KEPATUHAN WAJIB PAJAK UMKM e-COMMERCE

Di Indonesia, Usaha Mikro Kecil dan Mengengah (UMKM) memliki peran penting dalam perekonomian masyarakat.Dengan tren bisnis pada masyarakat selama 5 tahun terakhir ini yaitu bisnis e-commerce, kini semakin banyak pelaku bisnis yang menjalankan UMKM e-commerce.Banyaknya jumlah UMKM semestinyasebanding dengan banyaknyajumlah pajak yang diterima dari sektor UMKM, namun pada kenyataannya dinyatakan oleh Direktorat Jenderal Pajak (DJP) bahwa UMKM belum maksimal berkontribusi dalam penerimaan pajak.Keberhasilan upaya penerimaan pajak ini ditentukan oleh beberapa hal yang saling berkaitan yaitu kemampuan UMKM dalam mengelola keuangan bisnis yang tentunya diperlukan penerapan akuntansi UMKM yang cukup.Tujuan penelitian ini yaitu menguji pengaruh penerapan akuntansi UMKM terhadap kepatuhan wajib pajak UMKM e-commerce dengan menambahkan pemahaman perpajakan, kesadaran wajib pajak, dan kemudahan akses sebagai variabel kontrol. Penelitian ini menggunakan teknik kuesioner. Sampel yang digunakan yaitu sebanyak 90 responden dengan metode convenience sampling. Teknik analisis yang digunakan dalam penelitian ini yaitu Multiple Regression Analysis. Hasil yang ditunjukkan penelitian ini bahwa penerapan akuntansi UMKM berpengaruh positif pada kepatuhan Wajib Pajak UMKM e-commerce. Sedangkan variabel kontrol yang mempengaruhi yaitu pemahaman perpajakan dan kemudahan akses.Variabel kesadaran Wajib Pajak tidak terbukti sebagai variabel kontrol dalam penelitian ini.