Miracle-dz/UniFAR-FTUs huggingface dataset:
Success of Data Resource Management in Distributed Environments: An Empirical Investigation

The trend toward distributed processing has significantly increased the awareness of data as a key corporate resource and underscored the importance of its management. In spite of this, there is a lack of empirical investigation of issues related to data resource management (DRM) in distributed processing environments. Being perhaps the first empirical attempt, this exploratory study identifies four information systems (IS) variables related to DRM in a distributed environment. It also seeks to examine the notion of gestalt fit to describe the nature of the relationships among these variables. In addition, the study evaluates whether intemally congruent groups outperform their opposites in realizing DRM success. The results of cluster analysis support the view of gestalt fit by identifying five clusters. The results also suggest that organizations represented by a well-blended configuration of high intersite data dependence, high centralization of IS decisions, high concentration IS resources at the central site, and low DRM-related autonomy granted to local sites appear to realize a greater degree of DRM success than the other groups. The implications of the study are discussed, and further research directions are proposed.
INHIBITION OF C-RAF EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES EXTENDS HEART ALLOGRAFT SURVIVAL IN RATS1

Background. C-raf is a well-characterized serine/threonine (Ser/Thr) protein kinase that is involved in the transduction of multiple signals of T cells. We demonstrate that the inhibition of C-raf mRNA expression prolongs heart allograft survival. Methods. Three 20-mer C-raf antisense oligonucleotides, each with identical sequences, were synthesized with different chemical modifications: one as a uniform phosphorothioate oligodeoxynucleotide (PS oligo), a second with a PS backbone and 2′-methoxyethyl (ME) substitutions at the 2′-sugar positions in the first and last five nucleotides, and a third with a mixed PS and phosphodiester (PD) backbone and ME modifications on the first and last five nucleotides. Results. Both ME-modified C-raf antisense oligos were at least 5-fold more effective than the PS C-raf antisense oligo in blocking C-raf mRNA expression in two cell lines. Similarly, each of the ME C-raf antisense oligos produced better heart allograft survival rates than did PS C-raf oligo. Furthermore, although the combination of PS C-raf antisense oligo with sirolimus (SRL) acted synergistically to extend heart allograft survival, the effect was potentiated by either of the ME-modified oligos. Conclusions. C-raf inhibition extends heart allograft survival, and ME-modification potentiates antisense activity.
Default Risk of Mortgage Credits for Lenders

This paper applies a conditional copula model to investigate the dependence structure of house prices and default rates by analyzing their extreme dependence in order to quantify the default risk of mortgage credits for lenders. Therefore, we use housing supply factors and economic factors as well as interest rates and mortgage loan-to-price ratios as explaining variables. Examining quarterly data from 1985 to 2015 we find that new housing units starts, the existing mortgage loan-to-price ratio as well as the home mortgage loan-to-price ratio can be used to quantify the default risk of mortgage credits for lenders.
MEKANISME CORPORATE GOVERNANCE, MANAJEMEN LABA DAN KINERJA KEUANGAN (Studi Pada Perusahaan Go-Publik Sektor Manufaktur)

The principal purpose of this study was to examine the influence of corporate governancemechanism with earnings management and influence concequensies of earnings managementto financial performance. Measurement of corporate governance mechanism consist of: institutionalownership, managerial ownership, presence of independent of director and size of director.Institutional ownership, manajerial ownership and presence of independent of director canaffect the action of earning management, which caused in the use of discretionary accruals intothe lower. Whereas the small size of director would be more effective in performing supervisoryaction of earnings management. Earnings management is conducted by managers on firmfundamental factors, namely the nterventon on making of financial statement based on accrualaccounting. So that eranings management will affect performed by managers on the factors- fundamental factors the company, by intervention in the preparation of financial statementsbased on accrual accounting. So that earnings management will affect financial performance.The populations of this research is all of companies in the manufacturing sector at the IndonesianStock Exchange, which were published in financial report from 2005-2007. Purposive samplingmethod was used to determine research sample. From this method, we have collected 37observations.By using multiple regression analysis as the research method, the findings are: manajerial ownershipinfluence negatively to earnings management and size of director influence positively toearning management as hypothesized. Institutional ownership and presence of independentof director had not significant influence to earnings management. Earning management havesignificant effects on financial performance.Keywords: corporate governance mechanism, eearnings management and financial performance
The direct and indirect influence of brand image, brand experience, and brand personality on brand loyalty

The objective of this study is to investigate the relationships between brand image (BI), brand experience (BE), brand personality (BP), and brand loyalty (BL) of automobile local brands in Malaysia and also determining the mediating effect of brand satisfaction (BS) and brand trust (BT) on those relationships. This study is embarked on the fact that only a few studies have examined how brand image, brand experience, brand personality, brand satisfaction, and brand trust contribute towards the emergence of brand loyalty. Based on a theoretical consideration, a model was proposed and 17 hypotheses were formulated. Questionnaires were used to collect data. A total of 330 usable responses were received from respondents in the northern part of Malaysia, (Kedah, Penang, and Perlis). Partial Least Squares Structural Equation Modelling (PLS-SEM) was employed in the data analysis. The findings reveal significant relationships between brand image and brand loyalty, and between brand experience and brand loyalty. However, this study does not find any significant relationships between brand personality and brand loyalty. This study observes that brand satisfaction mediates both the relationships between brand image, brand personality, and brand loyalty. In addition, brand trust mediates the relationships between brand personality and brand loyalty. However, brand satisfaction does not mediate the relationships between brand experience and brand loyalty. No significant mediation is observed of brand trust on the relationships between brand image, brand experience, and brand loyalty. The significance of this study can be seen in the incorporation of brand satisfaction and brand trust as the mediating tools to explain the relationships between brand image, brand experience, brand personality, and brand loyalty. The study concludes with a discussion on the contributions, limitations as well as suggestions for future research
Ovarian hormone fluctuation, neurosteroids, and HPA axis dysregulation in perimenopausal depression: a novel heuristic model.

OBJECTIVE In this conceptual review, the authors propose a novel mechanistic candidate in the etiology of depression with onset in the menopause transition ("perimenopausal depression") involving alterations in stress-responsive pathways, induced by ovarian hormone fluctuation. METHOD The relevant literature in perimenopausal depression, including prevalence, predictors, and treatment with estrogen therapy, was reviewed. Subsequently, the growing evidence from animal models and clinical research in other reproductive mood disorders was synthesized to describe a heuristic model of perimenopausal depression development. RESULTS The rate of major depressive disorder and clinically meaningful elevations in depressive symptoms increases two- to threefold during the menopause transition. While the mechanisms by which ovarian hormone fluctuation might impact mood are poorly understood, growing evidence from basic and clinical research suggests that fluctuations in ovarian hormones and derived neurosteroids result in alterations in regulation of the HPA axis by γ-aminobutyric acid (GABA). The authors' heuristic model suggests that for some women, failure of the GABAA receptor to regulate overall GABA-ergic tone in the face of shifting levels of these neurosteroids may induce HPA axis dysfunction, thereby increasing sensitivity to stress and generating greater vulnerability to depression. CONCLUSIONS The proposed model provides a basis for understanding the mechanisms by which the changing hormonal environment of the menopause transition may interact with the psychosocial environment of midlife to contribute to perimenopausal depression risk. Future research investigating this model may inform the development of novel pharmacological treatments for perimenopausal depression and related disorders, such as postpartum depression and premenstrual dysphoric disorder.
Agency Costs of Free Cash Flows and Investments in Business Sustainability

This paper extends the literature on the determinants of environment, social and governance (ESG) dimensions of sustainability investment by examining whether low growth firms with the agency problems of high free cash flows (FCF) (Jensen, 1986) have more incentives to invest in ESG sustainability. We use sustainability performance as a proxy for sustainability investment, since sustainability performance does not emerge naturally and firms must have invested in sustainability to attain performance. The results indicate that firms with high FCF are associated with higher levels of ESG sustainability investment, after controlling for dividend distributions, debt interest payments and investment expenditure for maintaining asset-in-place and acquiring new investment. We also find that high FCF firms with high investments in ESG sustainability are associated with higher market returns than similar firms with low investments in ESG.
Transferring local human capital: Geographical proximity and perceived employees? productivity

While there is a wealth of literature dealing with the spatial nature of knowledge and its transferral, I argue that the underlying mechanisms have not been sufficiently understood. Existing research relating the geography of inflows to firm productivity does not adequately address firm and individual level heterogeneity. Some issues that are not tackled are the following. First, knowledge differentness might be the most important for the most skilled employees that can be expected to have the greatest impact on firm's productivity. Second, distant job matches might be a selective sample: greater spatial mobility enables finding better matches based on non-spatial human capital. Third, nonlocal job matches might be different along several dimensions and it is not clear where exactly the benefits of different knowledge are realised and where the bottlenecks occur. In this paper I fill this gap by making an attempt to disentangle the reasons behind different productivity levels of local and nonlocal employees. I employ the framework of Simon and Warner [Journal of Labor Economics, 10(3), 1992). I look into wage growth between jobs, tenure and wage growth on the job to infer about the initial certainty about employee's productivity, the quality and riskiness of job matches. I argue that different productivity levels can be determined by nonlocal employees being outsiders to local working culture, business practices, knowledge base and networks. In addition, since job matches made over long geographical distances are costly and parties might be unwilling to commit so such job matches unless they have much trust in their quality, distant job matches might be a selective sample where the non-spatial human capital is matched better than in local job matches. I expect the selectivity to drive up wage growth between jobs, tenure and wage growth on the job. Not possessing local knowledge, on the other hand, is expected to drive them all down. A dataset is used that is based on register data for the Netherlands 2008-2012 linked to survey data. Preliminary findings show that in general, nonlocal employees experience a higher wage growth between jobs. They have shorter tenures and on-the-job wage growth that is not different in a statistically significant way from that of the local employees; those findings together indicate worse job matches. Yet if being nonlocal is instrumented, all of those effects become statistically not significant.
Anisotropic Helmholtz and wave–vortex decomposition of one-dimensional spectra

We present an extension to anisotropic flows of the recently developed Helmholtz and wave–vortex decomposition method for one-dimensional spectra measured along ship or aircraft tracks in Bühler et al. (J. Fluid Mech., vol. 756, 2014, pp. 1007–1026). Here, anisotropy refers to the statistical properties of the underlying flow field, which in the original method was assumed to be homogeneous and isotropic in the horizontal plane. Now, the flow is allowed to have a simple kind of horizontal anisotropy that is chosen in a self-consistent manner and can be deduced from the one-dimensional power spectra of the horizontal velocity fields and their cross-correlation. The key result is that an exact and robust Helmholtz decomposition of the horizontal kinetic energy spectrum can be achieved in this anisotropic flow setting, which then also allows the subsequent wave–vortex decomposition step. The anisotropic method is as easy to use as its isotropic counterpart and it robustly converges back to it if the observed anisotropy tends to zero. As a by-product of our analysis we also found a simple test for statistical correlation between rotational and divergent flow components. The new method is developed theoretically and tested with encouraging results on challenging synthetic data as well as on ocean data from the Gulf Stream.
Angina pectoris and normal coronary arteries: cardiac syndrome X

Among patients undergoing coronary angiography because of angina typical enough to suggest coronary artery disease, 10–30% are found to have “normal” or “near normal” epicardial coronary arteries at angiography. A group of these patients presents features of “cardiac syndrome X”, which is typically characterised by: However, several groups of patients presenting with angina pectoris and normal coronary arteries do not fall into the strict definition of syndrome X, including those with predominant rest angina, those with hypertension or diabetes, or those with lack of ischaemic-like ECG changes during angina. It is still largely unknown whether the pathogenesis of angina in these various subsets of patients is different from that of angina in patients with typical syndrome X. Nevertheless, patients with typical and non-typical syndrome X have frequently been pooled together, thus making comparisons among different studies rather problematic. Therefore, a consensus document on the definition, classification, and management of patients with angina and normal coronary arteries would be very useful. Syndrome X is characterised by two major abnormalities, which may combine variously to determine the individual clinical picture: (1) coronary microvascular dysfunction; and (2) abnormal cardiac pain sensitivity. ### Microvascular dysfunction Since its first description it was suggested that, in syndrome X, angina is caused by myocardial ischaemia determined by a dysfunction of small resistance coronary artery vessels (< 500 μm) not visible at coronary angiography, a condition defined as “microvascular angina”. 1 The occurrence of myocardial ischaemia in these patients is indicated by transient ST segment depression and reversible perfusion defects …
Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis.

CONTEXT Ephedra and ephedrine sometimes are used for weight loss or enhanced athletic performance, but the efficacy and safety of these compounds are uncertain. OBJECTIVE To assess the efficacy and safety of ephedra and ephedrine used for weight loss and enhanced athletic performance. DATA SOURCES We searched 9 databases using the terms ephedra, ephedrine, adverse effect, side effect, efficacy, effective, and toxic. We included unpublished trials and non-English-language documents. Adverse events reported to the US Food and Drug Administration MedWatch program were assessed. STUDY SELECTION Eligible studies were controlled trials of ephedra or ephedrine used for weight loss or athletic performance and case reports of adverse events associated with such use. Eligible studies for weight loss were human studies with at least 8 weeks of follow-up; and for athletic performance, those having no minimum follow-up. Eligible case reports documented that ephedra or ephedrine was consumed within 24 hours prior to an adverse event or that ephedrine or an associated product was found in blood or urine, and that other potential causes had been excluded. Of the 530 articles screened, 52 controlled trials and 65 case reports were included in the adverse events analysis. Of more than 18 000 other case reports screened, 284 underwent detailed review. DATA EXTRACTION Two reviewers independently identified trials of efficacy and safety of ephedra and ephedrine on weight loss or athletic performance; disagreements were resolved by consensus. Case reports were reviewed with explicit and implicit methods. DATA SYNTHESIS No weight loss trials assessed duration of treatment greater than 6 months. Pooled results for trials comparing placebo with ephedrine (n = 5), ephedrine and caffeine (n = 12), ephedra (n = 1), and ephedra and herbs containing caffeine (n = 4) yielded estimates of weight loss (more than placebo) of 0.6 (95% confidence interval, 0.2-1.0), 1.0 (0.7-1.3), 0.8 (0.4-1.2), and 1.0 (0.6-1.3) kg/mo, respectively. Sensitivity analyses did not substantially alter the latter 3 results. No trials of ephedra and athletic performance were found; 7 trials of ephedrine were too heterogeneous to synthesize. Safety data from 50 trials yielded estimates of 2.2- to 3.6-fold increases in odds of psychiatric, autonomic, or gastrointestinal symptoms, and heart palpitations. Data are insufficient to draw conclusions about adverse events occurring at a rate less than 1.0 per thousand. The majority of case reports are insufficiently documented to allow meaningful assessment. CONCLUSIONS Ephedrine and ephedra promote modest short-term weight loss (approximately 0.9 kg/mo more than placebo) in clinical trials. There are no data regarding long-term weight loss, and evidence to support use of ephedra for athletic performance is insufficient. Use of ephedra or ephedrine and caffeine is associated with increased risk of psychiatric, autonomic, or gastrointestinal symptoms, and heart palpitations.
Perspective - Making Doubt Generative: Rethinking the Role of Doubt in the Research Process

In this paper, we want to shift the attention of our scholarly community to the living condition of doubt and its underappreciated significance for the theorizing process. Drawing on Peirce's notion of abduction, we articulate the relationship between doubt and belief in the everyday imaginative work central to theorizing, and establish the role played by doubt as abduction's engine in these efforts. We propose three strategic principles for engaging and using doubt in the research process. In concluding, we explore our field's overemphasis on validation to the exclusion of discovery processes and to the detriment of excellence in theorizing. We call for a broadening of our notions of “methodology” to incorporate discovery processes and to begin their explication.
Microbial Geography of the Oral Cavity

We aimed to determine the bacterial diversity of different oral micro-niches and to assess whether saliva and plaque samples are representative of oral microbial composition. We took minute samples from each surface of the individual teeth and gingival crevices of two healthy volunteers (112 samples per donor), as well as samples from the tongue dorsum and non-stimulated and stimulated saliva. DNA was extracted from 67 selected samples of each donor, and the 16S rRNA gene was amplified by PCR and pyrosequenced to obtain, on average, over 2,700 reads per sample, which were taxonomically assigned to obtain a geographic map of bacterial diversity at each tooth and sulcus location. Analysis of the data shows considerable differences in bacterial composition between teeth at different intra-oral locations and between surfaces of the same tooth. The most pronounced differences were observed in incisors and canines, where genera like Streptococcus were found at 40% to 70% on the vestibular surfaces but were almost absent on the lingual sides. Saliva samples, especially non-stimulated saliva, were not representative of supra-and subgingival plaque in the two individuals tested. We suggest that more precise sampling is required for the proper determination of oral microbial composition and to relate that diversity to epidemiological, clinical, and etiological parameters.
Coal Transitions in China's power sector: A plant-level assessment of stranded assets and retirement pathways

OVERINVESTMENT IN NEW COAL PLANT This paper estimates the potential scale of stranded assets in the coal power sector in China under different policy scenarios. A number of factors are putting significant pressure on the coal-power sector: a recent investment bubble in new capacity, structural slowing in electricity demand growth, upcoming moves to liberalize electricity markets and introduce a carbon market, and continued support for renewable and low-carbon sources of electricity. Stranded assets in the Chinese coal-fired power sector are estimated at 90 billion USD2015 under the current policy trajectory (NDC-Style Scenario). This situation threatens to increase the political economy challenges of China’s electricity sector transition to a low-carbon system. This situation is not unique to China: other countries will also face coal-sector stress due to the competitiveness of renewables, and therefore managing existing coal power capacities needs to move to the forefront of climate and energy policy efforts.