Miracle-dz/UniFAR-FTUs huggingface dataset:
SCALEDEEP: A scalable compute architecture for learning and evaluating deep networks

Deep Neural Networks (DNNs) have demonstrated state-of-the-art performance on a broad range of tasks involving natural language, speech, image, and video processing, and are deployed in many real world applications. However, DNNs impose significant computational challenges owing to the complexity of the networks and the amount of data they process, both of which are projected to grow in the future. To improve the efficiency of DNNs, we propose SCALEDEEP, a dense, scalable server architecture, whose processing, memory and interconnect subsystems are specialized to leverage the compute and communication characteristics of DNNs. While several DNN accelerator designs have been proposed in recent years, the key difference is that SCALEDEEP primarily targets DNN training, as opposed to only inference or evaluation. The key architectural features from which SCALEDEEP derives its efficiency are: (i) heterogeneous processing tiles and chips to match the wide diversity in computational characteristics (FLOPs and Bytes/FLOP ratio) that manifest at different levels of granularity in DNNs, (ii) a memory hierarchy and 3-tiered interconnect topology that is suited to the memory access and communication patterns in DNNs, (iii) a low-overhead synchronization mechanism based on hardware data-flow trackers, and (iv) methods to map DNNs to the proposed architecture that minimize data movement and improve core utilization through nested pipelining. We have developed a compiler to allow any DNN topology to be programmed onto SCALEDEEP, and a detailed architectural simulator to estimate performance and energy. The simulator incorporates timing and power models of SCALEDEEP's components based on synthesis to Intel's 14nm technology. We evaluate an embodiment of SCALEDEEP with 7032 processing tiles that operates at 600 MHz and has a peak performance of 680 TFLOPs (single precision) and 1.35 PFLOPs (half-precision) at 1.4KW. Across 11 state-of-the-art DNNs containing 0.65M-14.9M neurons and 6.8M-145.9M weights, including winners from 5 years of the ImageNet competition, SCALEDEEP demonstrates 6×-28× speedup at iso-power over the state-of-the-art performance on GPUs.
The Sensitivity and Specificity of the Case Definition Criteria in Diagnosis of Headache: A School-Based Epidemiological Study of 5562 Children in Mersin

The objectives of the present study were to estimate the prevalence of recurrent headaches in schoolchildren (ranging from 2nd to 5th degrees) in Mersin city of Turkey and to determine the sensitivity, specificity, positive predictive value and positive likelihood ratio of the diagnostic headache characteristics in children with migraine and Tension Type Headache (TTH) using neurologist's diagnosis as the gold standard. The stratified sample of study was composed of 5562 children. The prevalence of recurrent headache was 49.2% (2739 of 5562) and the prevalence of current headache was 31.3% (859 of 2739). TTH was more common than migraine (24.7% vs. 10.4%). The most sensitive headache characteristic for migraine was ‘severity of pain’ and the most sensitive definitive symptom is ‘duration of headache’ in children with TTH. IHS-based symptom definition criteria are highly beneficial in diagnosis of childhood headache, if used together with detailed clinical assessment.
An empirical study of Internet usage pattern of undergraduate students in South Africa

The pattern of Internet use and the rate at which undergraduate students use the Internet should be greatly influenced by the primary purpose for which it has been provided (academic). The use pattern and use rate of the Internet for this purpose also has much to do with its adoption as a medium of meeting information needs over other media. The uses and gratifications theory on which this research is anchored, suggests that media use serves functions by some specific content or by the medium in question. It sees the audience as active seekers of media in a goal-oriented way that provides them with the means of gratifying a variety of needs and that media users are aware of their needs. 390 respondents were surveyed at the Nelson Mandela and Fort Hare Universities using quantitative and qualitative methods. With findings from the study indicating a 72.3%, attesting to making use of the Internet daily for an average of six hours, entertainment, communication and social networking purposes were the main activities undergraduate students spent the time on. The use of the Internet for academic purpose ranked last. From the findings of the study, the goal of undergraduate students when using the Internet, as assumed by UGT, is not to fulfil the cognitive need type. The use of the Internet is mainly driven by the desire to meet the social interaction need type (communication and social networking), which is not the primary reason which Institution provides free campus-wide Internet access.
Electrical Stimulation of the Paralyzed Orbicularis Oculi in Rabbit

Dysfunction of the seventh cranial nerve often results in facial paralysis and loss of the ability to blink the eye, which can lead to corneal scarring, diminished vision, and potential loss of the eye. This study investigated the potential of electrical stimulation of the orbicularis oculi muscle as a means of restoring blink function. An animal model of orbicularis paralysis was created by sectioning the seventh cranial nerve in rabbit. Twenty paralyzed and five normal rabbits were acutely implanted with a subcutaneous stimulating electrode near the margin of the upper eyelid. Biphasic current controlled stimulation pulses were delivered between implanted contacts at the medial and lateral edges of the eyelid. Strength-duration curves for lid twitch threshold were generated, and quantitative measurements of lid closure were made for systematically varied parameters including pulse amplitude, pulse width, number of pulses delivered, and duration of paralysis prior to stimulation. Normal rabbits achieved a greater degree of lid closure due to electrical stimulation than rabbits that had been surgically paralyzed. Of rabbits that had been paralyzed, those demonstrating evidence of at least partial reinnervation achieved a greater degree of lid closure than those demonstrating persistent denervation. Trains of 10 ms biphasic pulses delivered at 50 Hz were found to be the most effective means of eliciting lid closure for the range of parameters tested
Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls

Objective: Heat shock proteins (Hsps) have been repeatedly implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this work was to study Hsp mRNA and protein levels to determine whether they can be used to differentiate between RA, osteoarthritis (OA), and healthy controls. Methods: Hsp27, Hsp60, Hsp70, Hsp90α, and HspBP1 mRNA expression was analysed using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 24 RA, 11 OA, and 21 healthy controls. Hsp70 and HspBP1 protein levels were measured in serum using an enzyme-linked immunosorbent assay (ELISA). Results: Hsp gene expression profiles differ significantly between inflammatory (RA) and non-inflammatory (OA) joint diseases, showing significantly increased Hsp27 and Hsp90α mRNA levels in RA synovial tissues. Up-regulated Hsp60 and Hsp90α together with down-regulated Hsp70 and elevated HspBP1/Hsp70 mRNA ratios can be used to differentiate between RA patients and healthy individuals through analysis of peripheral blood samples. Despite increased HspBP1 levels in RA sera, Hsp70 levels and the HspBP1/Hsp70 protein ratio remained identical in the RA patients and healthy individuals, which may contribute to the inhibition of Hsp70 anti-apoptotic activity. Conclusion: Hsp gene expression analysis can be implemented as a new diagnostic approach to facilitate differentiation between RA, OA, and healthy controls.
How Important are Wealth Effects on Consumption in Canada?

We estimate the marginal propensity to consume from financial and housing wealth in Canada. The modelling framework of Carroll et al. (2011) that builds on the observed stickiness in consumption data is used. Estimations and inferences are conducted using identification-robust methods. The results provide support for the overall modelling strategy, but there are also important differences in the identification status of the econometric equations considered. Based on the most informative specification, we find that both types of wealthfinancial and housinghave significant effects in Canada and that the former has a greater effect than the latter. A simple extension of the model that also accounts for non-price credit conditions shows that housing wealth may be relevant only during periods of easier access to credit. Finally, we find support for relatively high stickiness in consumption growth in Canada.
Deconstructing delays in sovereign debt restructuring

Negotiations to restructure sovereign debt are time consuming, taking almost a decade on average to resolve. In this paper, we analyze a class of widely used complete information models of delays in sovereign debt restructuring and show that, despite superficial similarities, there are major differences across models in the driving force for equilibrium delay, the circumstances in which delay occurs, and the efficiency of the debt restructuring process. We focus on three key assumptions. First, if delay has a permanent effect on economic activity in the defaulting country, equilibrium delay often occurs; this delay can sometimes be socially efficient. Second, prohibiting debt issuance as part of a settlement makes delay less likely to occur in equilibrium. Third, when debt issuance is not fully state contingent, delay can arise because of the risk that the sovereign will default on any debt issued as part of the settlement.
Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western world. Alterations in microRNAs (miRNAs) expression have been proposed to play a role in CLL pathogenesis. Dicer and Drosha are the main regulators of miRNA biogenesis, and deregulation of their expression has been indicated as a possible cause of miRNA alterations observed in various cancers. To investigate the role of Dicer and Drosha in CLL, we assessed the expression of Dicer and Drosha and their correlation with other prognostic factors, including Binet stages, immunoglobulin heavy chain variable gene (IGHV) mutation status, TP53 mutation status, ZAP‐70 protein and CD38 expression level in 165 CLL patients by using real‐time polymerase chain reaction methods. Patients with unmutated IGHV genes had significantly lower expression of Dicer than patients with IGHV mutations. The lower expression level of Dicer was also significantly associated with higher level of CD38 and ZAP‐70, and more aggressive Binet stage. We also analyzed Dicer expression in different cytogenetic subgroups. Lower Dicer level was found in patients with unfavorable cytogenetic aberrations (deletion in 17p13 or 11q22.3) in contrast to higher level in good risk cytogenetics (deletion in 13q14 as the sole abnormality). Furthermore, the lower expression of Dicer in CLL shows a strong association with shorter overall survival (OS) (P = 0.0046) as well as with reduced treatment free survival (TFS) (P = 0.0006). By contrast, no differences in the expression of Drosha among these groups of patients were observed. Our data suggest that Dicer expression may play an important role in the progression and prognosis of CLL. (Cancer Sci 2012; 103: 875–881)
Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopamine neurons in the rat: acute and chronic studies.

The present experiments compared the ability of a new potential antipsychotic drug, BMY 14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine- butanol), to alter the electrophysiological activity of midbrain dopamine (DA) neurons in the rat substantia nigra (A9) and ventral tegmental area (A10). Intravenous administration of BMY 14802 reversed the rate-suppressant effects of the DA agonist apomorphine on both A9 and A10 DA neurons; however, this reversal occurred at significantly lower doses in A10 than in A9. These effects of BMY 14802 appeared not to be mediated by DA receptors because, unlike the established antipsychotic drugs haloperidol and clozapine, BMY 14802 pretreatment failed to block apomorphine-induced suppression of A10 DA cells. Repeated s.c. administration (28 days) of BMY 14802 (2.5-10.0 mg/kg) reduced the number of spontaneously active A10 DA cells recorded per electrode track without affecting the number of A9 DA cells. This inactivation of A10 DA neurons was only partially reversed by the administration of apomorphine. Thus, it is uncertain as to whether this effect was produced by depolarization block as occurs during repeated administration of known antipsychotic drugs. These findings indicate that BMY 14802 influences DA neurotransmission by a nondopaminergic (perhaps sigma opioid) mechanism. The more potent effect of BMY 14802 on A10 DA neurons suggests that this novel compound may exert antipsychotic effects without producing significant extrapyramidal side effects.
Some macrophages kill Listeria monocytogenes while others do not

Summary: It is not known why some macrophages can kill certain microbes, such as the facultative intracellular bacterium Listeria monocytogenes (L. monocytogenes), while other macrophages cannot. Perhaps listericidal activity is a property of macrophages at specific stages of differentiation; maybe the ability to kill this bacterium is regulated by the microenvironment of the cell; or it is possible that other regulatory forces are important. We describe here three characteristics that distinguish macrophages which can kill I. monocytogenes from those which cannot. First, listericidal macrophages must have neither too much nor too little intracellular iron ‐ they must have an intermediate amount. Second, the receptor a macrophage uses to phagocytose L. monocytogenes seems to influence the intracellular fate of this bacterium. And third, macrophages which have cell‐surface interleukin‐10 (IL‐10), a known down regulator of macrophage function, can‐not kill L. monocytogenes. These trails of macrophages and their effects on listericidal activity are reviewed here, and the possibility that these properties might interact to control macrophage bactericidal activity is discussed.
The effects of maternal thyroid hormone function on early pregnancy

Purpose of review It is unclear whether pregnancy outcomes are impacted by nonovert thyroid disease, and whether detection and treatment of abnormalities improve outcomes. Consequently, there is an ongoing debate regarding universal thyroid screening in pregnancy. A lack of solid evidence has prompted researchers to evaluate the role of screening and to examine pregnancy outcomes in women with thyroid dysfunction. In addition, as IVF has developed into a commonly used procedure, its impact on thyroid function has also been investigated. The most current literature on these topics will be summarized in this review. Recent findings The multiple societies that have published guidelines on thyroid disease in pregnancy have developed different recommendations, with none definitively advocating for universal screening at this time. However, recent studies examining the role of screening have supported it from an economic and prevalence standpoint. Despite this, evidence has failed to consistently demonstrate that treatment of nonovert thyroid disorders improves maternal and fetal outcomes. Recent research does suggest that close monitoring for and treatment of thyroid dysfunction is warranted in women undergoing IVF. Summary Further research must be performed to determine whether treatment of nonovert thyroid disease during pregnancy impacts outcomes. Concrete evidence will likely influence the universal screening debate.
Development of baroreflex function and hind limb vascular reactivity in the horse fetus

This study investigated, in vivo, the mechanisms underlying the development of cardiovascular function in the horse fetus, with particular relevance to baroreflex function and hind limb vascular arterial reactivity to constrictor agonists. Under general anaesthesia, vascular catheters were inserted and a Transonic flow probe was implanted around one of the metatarsal arteries of 13 horse fetuses, either at 0.6 of gestation (n= 6) or at 0.9 of gestation (n= 7, term ∼335 days). At least 5 days after surgery, pressor, vasoconstrictor and cardiac chronotropic responses to exogenous bolus doses of phenylephrine, angiotensin II and arginine vasopressin were recorded. Fetal cardiac baroreflex slopes were obtained using the peak pressor and heart rate responses to increasing doses of phenylephrine. Fetal treatment with phenylephrine, angiotensin II and vasopressin produced significant changes in arterial blood pressure, hind limb vascular resistance and heart rate. Pressor and vasopressor responses to all agonists were greater at 0.9 than at 0.6 of gestation; however, fetal cardiac baroreflex sensitivity decreased with advancing gestational age. Correlation analysis revealed that fetal plasma cortisol rather than gestational age was a greater determinant of pressor and vasopressor reactivity. In contrast, gestational age rather than cortisol better determined heart rate and baroreflex responsiveness in the equine fetus. The data show that development of cardiovascular function in the equine fetus occurs via cortisol‐dependent and ‐independent pathways.
Credit Regimes and the Seeds of Crisis

This paper presents a theory of mortgage credit that explains (1) the rise of non-prime lending during the early 2000’s, (2) the simultaneous housing boom, and (3) the subsequent crisis. The theory is built on rational and competitive behavior by lenders in response to asymmetric information about borrower income risk. Two possible credit regimes may arise. In the “screening” regime, lenders ration credit through documentation requirements (screening contracts) and down-payment requirements (separating contracts). In the alternative “pooling” regime, risky borrowers gain access to low-doc low-down mortgages (pooling contracts). Joint housing and mortgage market equilibrium implies a tipping point phenomenon — a fall in income risk can trigger the pooling regime, lead to a sudden fall in documentation requirements, and, due to an indifference condition switching effect, generate a rapid appreciation in home prices. A housing crisis follows this credit-fueled boom once fundamentals revert and the screening regime returns. The theory matches microeconomic evidence on the allocation of credit during the mid-2000’s, explains why mortgage rates fell relative to treasury yields during 2003, and provides a framework to assess policies intended to rule out future housing crises.
Education and Economic Growth: Empirical Evidence from Nigeria

Experts opined that education affects the society both at the micro and macro levels. However, the place of education has not been given its right place in Nigeria as reflected in the nation’s budgetary allocations. Hence, this study examined the impact of different levels of education on different components of growth in Nigeria. Data were sourced from the CBN Statistical Bulletin (see http://www.cbn.gov.ng/documents/statbulletin.asp), the Nigerian Bureau of Statistics (see http://www.nigerianstat.gov.ng) and The World Bank (see http://www.worldbank.org) from 1970–2015. The Fully Modified ols estimator was used and the results revealed that different levels of education impact at varying magnitude on each of the components of growth positively in Nigeria but the magnitude of the impact is much higher from completion rate. By implication completion rate explains growth at a higher magnitude than enrolment rates in Nigeria, therefore government should endeavour to provide modalities to curtail school dropout rate in the schooling system as a measure to boost completion rates that will facilitate growth.
Matching and Inverse Propensity Weighting Estimates of the Union Wage Premium: Evidence from Canada, 1997–2014

I estimate the union wage premium for privateâ€ sector workers using Canadian data from Statistics Canada's Labour Force Survey from 1997 to 2014, examining the trend and gender differences in the premium. I obtain my estimates using matching and inverse propensity weighting estimators, which form counterfactuals for union workers. These estimators create better covariate balance and can also be used to address the bias that arises from the log transformation of wages.
[Evaluation of factors associated with variability in retinal nerve fiber layer thickness in myopic juveniles aged 7-18 years].

OBJECTIVE To evaluate the relationship between retinal nerve fiber layer thickness(RNFLT)measured by optical coherence tomography (OCT) and age, spherical equivalent (SE), axial length, and gender in myopic juveniles. METHODS Cross-sectional observational study. One hundred and fifty-four juveniles (age range, 7-18 years) underwent ophthalmic examinations. Peripapillary Fast RNFL scans were performed by Stratus OCT with a nominal diameter of 3.46 mm centered on the optic disc on one randomly selected eye of each subject. Axial length was measured by A-ultrasound. The effects of several factors (age, SE, axial length, gender and eye) on RNFLT were investigated in univariate and multivariate stepwise regression analyses. RESULTS The mean global RNFLT (x(-) ± s) was (114.106 ± 11.473) µm. The RNFLT was thickest superiorly (145.468 ± 19.064) µm and inferiorly (138.091 ± 20.464) µm, thinner temporally (94.396 ± 18.544) µm, and thinnest nasally (78.558 ± 16.981) µm. Both global and superior peripapillary RNFLT had no significant relationship with age (r = 0.129, 0.014; P > 0.05), SE (r = 0.006, 0.123; P > 0.05), axial length (r = -0.067, -0.141; P > 0.05), gender (r = -0.095, 0.025; P > 0.05) and laterality (r = -0.148, 0.095; P > 0.05). In multivariate stepwise regression analyses, there was significant inverse linear correlation between temporal RNFLT and SE (r = -0.465, P < 0.05). There was significant inverse linear correlation between nasal RNFLT and axial length and laterality (r = -0.327, P < 0.05). There was significant inverse linear correlation between inferior RNFLT and axial length (r = -0.276, P < 0.05), and direct linear correlation between inferior RNFLT and age (r = 0.276, P < 0.05). CONCLUSIONS When we assess the RNFLT in myopic juveniles, we should consider the influence of age, refraction, axial length, spherical equivalent and laterality comprehensively.
Degalactosylated/Desialylated Bovine Colostrum Induces Macrophage Phagocytic Activity Independently of Inflammatory Cytokine Production.

BACKGROUND/AIM Colostrum contains antibodies, such as immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM), and, therefore, has potent immunomodulating activity. In particular, IgA has an O-linked sugar chain similar to that in the group-specific component (Gc) protein, a precursor of the Gc protein-derived macrophage-activating factor (GcMAF). In the present study, we investigated the macrophage-activating effects of degalactosylated/desialylated bovine colostrum. RESULTS We detected the positive band in degalactosylated/ desialylated bovine colostrum by western blotting using Helix pomatia agglutinin lectin. We also found that degalactosylated/ desialylated bovine colostrum could significantly enhance the phagocytic activity of mouse peritoneal macrophages in vitro and of intestinal macrophages in vivo. Besides, degalactosylated/desialylated bovine colostrum did not mediate the production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). CONCLUSION Similar to the use of GcMAF, degalactosylated/desialylated bovine colostrum can be used as a potential macrophage activator for various immunotherapies.