Miracle-dz/UniFAR-FTUs huggingface dataset:
Caregiving Helplessness Questionnaire (CHQ) applied to Portuguese mothers of preschool-aged children: A psychometric study

O sistema de vinculação da criança é complementado por um sistema, separado e recíproco, de prestação de cuidados parentais, que guia as respostas de proteção do cuidador em relação à criança. Disrupções neste último sistema poderão conduzir a uma prestação de cuidados desorganizada; no entanto, o conhecimento acerca da desorganização da prestação de cuidados permanece incompleta, estando o seu estudo limitado a metodologias dispendiosas. O presente estudo pretendeu analisar as qualidades psicométricas do Caregiving Helplessness Questionnaire (CHQ), uma ferramenta de screening para a desorganização da prestação de cuidados, numa amostra de 200 mães portuguesas de crianças em idade pré-escolar. A análise factorial confirmatória não confirmou a estrutura da versão original do CHQ. Uma solução de cinco fatores verificou-se como sendo a melhor, produzindo cinco escalas conceptualmente correspondentes às principais dimensões da desorganização das relações em idade pré-escolar: Mother Helpless, Mother Frightened, Child Frightened, Child Cheers Mothers e Child Caregiving. O estudo da consistência interna obteve resultados satisfatórios e a validade convergente e discriminante foi confirmada. A validade concorrente também foi estabelecida através de associações significativas entre as escalas do CHQ e variáveis dos domínios materno e da criança que têm sido conceptual e empiricamente associadas com a desorganização. Em conclusão, os resultados suportam a validade do CHQ para mães portuguesas de crianças pré-escolares, como um instrumento de screening promissor desorganização da prestação de cuidados.
The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type.

RECENTLY SEVERAL INVESTIGATORS have reported that the genes for elliptocytosis and the Rh system may be closely linked (Goodall et al., 1953, 1954; Lawler and Sandier, 1954; Marshall et al., 1954). Other studies, however, did not suggest linkage (Chalmers and Lawler, 1953; Hollander, 1954; Fujii et al., 1955; Vandepitte and Louis, 1955). The data on this subject are unusually extensive, and they provide strong evidence of an autosomal linkage in man. Since these pedigrees also exemplify some of the difficulties encountered in the study of human linkage, it may be profitable to analyse them more closely.
Lead, Genetic Susceptibility, and Risk of Adult Brain Tumors

Background: Although few etiologic factors for brain tumors have been identified, limited data suggest that lead may increase the risk of brain tumors, particularly meningioma. The ALAD G177C polymorphism affects the toxicokinetics of lead and may confer genetic susceptibility to adverse effects of lead exposure. Methods: We examined occupational exposure to lead and risk of brain tumors in a multisite, hospital-based, case-control study of 489 patients with glioma, 197 with meningioma, and 799 non-cancer controls frequency matched on hospital, age, sex, race/ethnicity, and residential proximity to hospital. ALAD genotype was assessed by a Taqman assay for 355 glioma patients, 151 meningioma patients, and 505 controls. Exposure to lead was estimated using a rigorous questionnaire-based exposure assessment strategy incorporating lead measurement and other occupational data abstracted from published articles and reports. Results: Increased risk of meningioma with occupational lead exposure (estimated by odds ratios and 95% confidence intervals) was most apparent in individuals with the ALAD2 variant allele, for whom risk increased from 1.1 (0.3-4.5) to 5.6 (0.7-45.5) and 12.8 (1.4-120.8) for estimated cumulative lead exposures of 1 to 49 μg/m3-y, 50 to 99 μg/m3-y, and ≥100 μg/m3-y, respectively, compared with unexposed individuals (two-sided P trend = 0.06). This relationship became stronger after excluding occupational lead exposures characterized by a low confidence level or occurring in the 10 years before meningioma diagnosis. Occupational lead exposure was not associated with glioma risk. Conclusions: Although our results indicate that lead may be implicated in meningioma risk in genetically susceptible individuals, these results need to be interpreted with caution given the small numbers of exposed cases with a variant genotype. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2514–20)
Action of botulinum toxin on transmission from sympathetic nerves to the vas deferens

Botulinum toxin (Type A) depressed or abolished transmission from postganglionic nerves to smooth muscle of isolated preparations of guinea-pig and mouse vas deferens. The time course of blockade was 2 to 6 times slower than that observed with the same concentration of the same batch of toxin on the rat diaphragm. Spontaneous excitatory junction potentials were still observed after 7 h exposure, indicating that the smooth muscle membrane was still able to respond to noradrenaline. Depression of transmission is probably due to a presynaptic action of unknown nature.
Inferring recent migration rates from individual genotypes

We present a novel and straightforward method for estimating recent migration rates between discrete populations using multilocus genotype data. The approach builds upon a two‐step sampling design, where individual genotypes are sampled before and after dispersal. We develop a model that estimates all pairwise backwards migration rates (mij, the probability that an individual sampled in population i is a migrant from population j) between a set of populations. The method is validated with simulated data and compared with the methods of BayesAss and Structure. First, we use data for an island model and then we consider more realistic data simulations for a metapopulation of the greater white‐toothed shrew (Crocidura russula). We show that the precision and bias of estimates primarily depend upon the proportion of individuals sampled in each population. Weak sampling designs may particularly affect the quality of the coverage provided by 95% highest posterior density intervals. We further show that it is relatively insensitive to the number of loci sampled and the overall strength of genetic structure. The method can easily be extended and makes fewer assumptions about the underlying demographic and genetic processes than currently available methods. It allows backwards migration rates to be estimated across a wide range of realistic conditions.
THE ASYMPTOTIC GIANT BRANCH AND THE TIP OF THE RED GIANT BRANCH AS PROBES OF STAR FORMATION HISTORY: THE NEARBY DWARF IRREGULAR GALAXY KKH 98

We investigate the utility of the asymptotic giant branch (AGB) and the red giant branch (RGB) as probes of the star formation history (SFH) of the nearby (D = 2.5 Mpc) dwarf irregular galaxy, KKH 98. Near-infrared (near-IR) Keck Laser Guide Star Adaptive Optics (AO) images resolve 592 IR-bright stars reaching over 1 mag below the tip of the RGB. Significantly deeper optical (F475W and F814W) Hubble Space Telescope images of the same field contain over 2500 stars, reaching to the red clump and the main-sequence turnoff for 0.5 Gyr old populations. Compared to the optical color–magnitude diagram (CMD), the near-IR CMD shows significantly tighter AGB sequences, providing a good probe of the intermediate-age (0.5–5 Gyr) populations. We match observed CMDs with stellar evolution models to recover the SFH of KKH 98. On average, the galaxy has experienced relatively constant low-level star formation (5 × 10−4 M☉ yr−1) for much of cosmic time. Except for the youngest main-sequence populations (age <0.1 Gyr), which are typically fainter than the AO data flux limit, the SFH estimated from the 592 IR-bright stars is a reasonable match to that derived from the much larger optical data set. Differences between the optical- and IR-derived SFHs for 0.1–1 Gyr populations suggest that current stellar evolution models may be overproducing the AGB by as much as a factor of 3 in this galaxy. At the depth of the AO data, the IR-luminous stars are not crowded. Therefore, these techniques can potentially be used to determine the stellar populations of galaxies at significantly further distances.
RADIO EMISSION AND ORBITAL MOTION FROM THE CLOSE-ENCOUNTER STAR–BROWN DWARF BINARY WISE J072003.20–084651.2

We report the detection of radio emission and orbital motion from the nearby star–brown dwarf binary WISE J072003.20–084651.2AB. Radio observations across the 4.5–6.5 GHz band with the Very Large Array identify at the position of the system quiescent emission with a flux density of 15 ± 3 μJy, and a highly polarized radio source that underwent a 2–3 minute burst with peak flux density 300 ± 90 μJy. The latter emission is likely a low-level magnetic flare similar to optical flares previously observed for this source. No outbursts were detected in separate narrow-band Hα monitoring observations. We report new high-resolution imaging and spectroscopic observations that confirm the presence of a co-moving T5.5 secondary and provide the first indications of three-dimensional orbital motion. We used these data to revise our estimates for the orbital period (4.1 − 1.3 + 2.7 ? > year) and tightly constrain the orbital inclination to be nearly edge-on (93.°6+1.°6−1.°4), although robust measures of the component and system masses will require further monitoring. The inferred orbital motion does not change the high likelihood that this radio-emitting very low-mass binary made a close pass to the Sun in the past 100 kyr.
Hostility and acute coronary syndrome in a transitional post-communist Muslim country: a population-based study in Tirana, Albania.

BACKGROUND The study aims to assess: (i) the association of hostility with socio-demographic, psychosocial and coronary risk factors and (ii) the association of hostility with acute coronary syndrome (ACS) in post-communist secular though predominantly Muslim Albania. METHODS In a population-based case-control study conducted in Tirana in 2003-06, 464 non-fatal sequential ACS patients (368 men, 96 women, 87% response) and a population-sampled control group (n = 684; 449 men, 235 women, 65.5% response) provided data on Cynical Distrust, a measure of hostility. The correlates of hostility in the population sample were assessed using the general linear model and the association of hostility with ACS in the case-control comparison by multivariable-adjusted logistic regression. RESULTS In the population-based sample, hostility was related to age (inversely in men), social position, social mobility, relative income (all inverse in both sexes) and emigration of close family. In the case-control comparison, there was a strong graded relationship of hostility with ACS, independent of socio-demographic characteristics and conventional coronary risk factors, including lifestyle/behavioural factors [odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.18-1.34 in men, and OR = 1.17, 95% CI = 1.05-1.32 in women per unit score of hostility and OR = 5.3, 95% CI = 3.3-8.6 in men and OR = 3.1, 95% CI = 1.1-8.6 in women for upper versus lower tertiles]. CONCLUSION This may be the first report from post-communist countries of Eastern and Southeastern Europe or from a Muslim population on the hostility trait in a population-representative sample. Hostility was independently associated with ACS. This requires confirmation, in particular, to exclude the possibility of reverse causality. Hostility may represent an informative risk factor in transitional populations.
Improving Patient-Centered Care: A Cross-Sectional Survey of Prior Use and Interest in Complementary and Integrative Health Approaches Among Hospitalized Oncology Patients.

OBJECTIVES To describe cancer inpatients' prior-year use of complementary and integrative health (CIH) therapies and interest in receiving CIH therapies while in the hospital. DESIGN Observational, cross-sectional survey of prior-year use of 12 different CIH approaches and interest in receiving any of 7 CIH services in the hospital. SETTING Surgical oncology ward of an academic medical center. PARTICIPANTS 166 hospitalized oncology patients, with an average age of 54 years. RESULTS The most commonly used CIH approach was vitamins/nutritional supplements (67%), followed by use of a special diet (42%) and manual therapies (39%). More than 40% of patients expressed interest in each of the therapies if it was offered during their hospital stay, and 95% of patients were interested in at least one. More than 75% expressed interest in nutritional counseling and in massage. CIH use and interest varied somewhat by demographic and clinical characteristics. CONCLUSION Rates of CIH use among patients with cancer were high, as were their preferences to have these services available in the inpatient setting. Hospitals have the opportunity to provide patient-centered care by developing capacity to provide inpatient CIH services.
Links between use of the secure base script and preschool children ’ s knowledge about emotions

The links between attachment security and multiple aspects of emotional development have been studied for several decades. Although these studies are valuable insofar some answers related to representations of attachment and emotion knowledge are still open. Preschool aged children (N=40) participated in this study. We used the Attachment Story Completion Task as their attachment measure, with representations measured as access to and use of the Secure Base Script (SBS) to organize children’s attachment relevant narratives. Emotional knowledge was assessed using the Affect Knowledge Test. Our main goal was to demonstrate that the SBS behaves like a typical measure of attachment representations with respect to its relations with children’s emotion understanding. Results suggested that children with secure attachment histories tend to have a larger fund of emotion knowledge. The SBS measure behaved similarly to other measures of attachment security suggesting its validity as a measure of attachment representations during early childhood.
Colorectal Cancers: An Update on Their Molecular Pathology

Colorectal cancers (CRCs) are the third leading cause of cancer-related mortality worldwide. Rather than being a single, uniform disease type, accumulating evidence suggests that CRCs comprise a group of molecularly heterogeneous diseases that are characterized by a range of genomic and epigenomic alterations. This heterogeneity slows the development of molecular-targeted therapy as a form of precision medicine. Recent data regarding comprehensive molecular characterizations and molecular pathological examinations of CRCs have increased our understanding of the genomic and epigenomic landscapes of CRCs, which has enabled CRCs to be reclassified into biologically and clinically meaningful subtypes. The increased knowledge of the molecular pathological epidemiology of CRCs has permitted their evolution from a vaguely understood, heterogeneous group of diseases with variable clinical courses to characteristic molecular subtypes, a development that will allow the implementation of personalized therapies and better management of patients with CRC. This review provides a perspective regarding recent developments in our knowledge of the molecular and epidemiological landscapes of CRCs, including results of comprehensive molecular characterizations obtained from high-throughput analyses and the latest developments regarding their molecular pathologies, immunological biomarkers, and associated gut microbiome. Advances in our understanding of potential personalized therapies for molecularly specific subtypes are also reviewed.
Online condition monitoring of wind turbines through three-phase electrical signature analysis

In the context of the KAStrion European project, a complete solution was proposed in order to monitor wind turbines. The developed solution comprises both hardware and software parts of the condition monitoring system. In terms of software, modules for vibration analysis and electrical signal analysis have been developed. The current paper presents the electrical analysis solution proposed in the context of this project. The electrical module is able to detect both mechanical and electrical faults in a wind turbine system. The goal of the mechanical fault detection using electrical signals is to confirm the faults also detected by vibration analysis, while the main focus of the module remains the detection of electrical faults. Results showing the performance of mechanical fault detection are presented using electrical signals acquired on the test-bench developed for testing the KAStrion system. Moreover, results regarding the electrical unbalance are presented using signals acquired on a three-phase transformer. The final solution has been implemented on two onshore wind turbines since the end of 2014, and online condition monitoring results are presented at the end of the paper.
Descriptor-Invariant Fusion Architectures for Automatic Subject Indexing

Documents indexed with controlled vocabularies enable users of libraries to discover relevant documents, even across language barriers. Due to the rapid growth of scientific publications, digital libraries require automatic methods that index documents accurately, especially with regard to explicit or implicit concept drift, that is, with respect to new descriptor terms and new types of documents, respectively. This paper first analyzes architectures of related approaches on automatic indexing. We show that their design determines individual strengths and weaknesses and justify research on their fusion. In particular, systems benefit from statistical associative components as well as from lexical components applying dictionary matching, ranking, and binary classification. The analysis emphasizes the importance of descriptor-invariant learning, that is, learning based on features which can be transferred between different descriptors. Theoretic and experimental results on economic titles and author keywords underline the relevance of the fusion methodology in terms of overall accuracy and adaptability to dynamic domains. Experiments show that fusion strategies combining a binary relevance approach and a thesaurus-based system outperform all other strategies on the tested data set. Our findings can help researchers and practitioners in digital libraries to choose appropriate methods for automatic indexing.
In Vitro Susceptibility of Community-Acquired Urinary Tract Pathogens to Commonly Used Antimicrobial Agents in Spain: a Comparative Multicenter Study (2002-2004)

Abstract The susceptibility patterns of 2724 uropathogens isolated in 9 Spanish regions during 2002, and 3013 obtained in 2004 were determined. The antibiotics tested were fosfomycin trometamol, amoxicillin, co-amoxiclav, cefixime, cefuroxime-axetil pipemidic acid, ciprofloxacin, trimethoprim plus sulphamethoxazole and nitrofurantoin. Escherichia coli was the main pathogen in both studies (73% vs. 68.3%) followed by Proteus mirabilis (7.2% vs. 6.4%) and Klebsiella pneumoniae (5.4% vs. 5.2%). Enterococcus spp. (4.7% vs. 6.8%)Streptococcus agalactiae (1.7% vs.3.1%) and Staphylococcus saprophyticus (0.7% vs. 1.3%) were the most frequent Gram-positive pathogens. 31.3% of E. coli in 2002 and 32% in 2004 were susceptible to all antibiotics tested. Around 40% of E. coli were resistant to a single agent. 21.6-24.1% were resistant to two antibiotics. 35.4% of first period isolates, and 37.6% of second period ones were resistant to two or more classes of antibiotics. Fosfomycin (2.1- 2.8%) and nitrofurantoin (3.5-5.7%) had the lowest resistance rates for E. coli. Amoxicillin (58.2-58.7%), co-trimoxazole (30.8-33.8%) and ciprofloxacin (22.6-22.7%) showed the highest resistance rates, and their suitability as empiric treatments for UTI should probably be re-evaluated.
Overweight and Obesity Prevalence among Public School Children in Guam

Background. The Government of Guam passed Public Law 28-87, which established the collection of child Body Mass Index (BMI) measurements in the Guam Department of Education (GDOE). This paper aimed to analyze the BMI data and report the childhood obesity prevalence on Guam. Methods. Secondary analysis was performed on a repeated cross-section of 106,827 children in the GDOE from 2010 to 2014. Age- and sex-specific prevalence estimates and 95% Confidence Intervals (CI) by weight status were calculated for each year. Test for trends in the high weight status were performed. Results. The childhood obesity prevalence was 23.1% (95% CI, 22.9%–23.4%). It declined from 23.6% (95% CI, 23.1%–24.1%) in 2010–2011 to 22.6% (95% CI, 22.1%–23.0%) in 2013–2014 (p=.007). Conclusion. Childhood obesity on Guam has declined, though it remains higher than the U.S. Mainland. Continued BMI data collection is needed to monitor childhood obesity and measure the impact of Public Law 28-87.
Investment strategies in the Brazilian industry of aluminum cans : an analysis in the context of real options games

Objective – The purpose of this article is to analyze the impact of preemption (first move advantage, with the consequent emergence of negative externalities to competitors) in situations that consider the optimal moment for investment, in the context of asymmetric oligopolies and using options games method. Design/methodology/approach – The developed model was applied to the Brazilian aluminum can industry, in which three firms made up an asymmetric oligopoly, allowing strategic interactions and their consequences on firms’ investment decisions to be analyzed. Findings – In situations of preemption, the results show the relevance of using a dynamic model, allowing us to observe the importance of obtaining a competitive advantage in cost, and showing that it is possible to obtain monopoly profits or take advantage of isolated expansion for a longer period. If this advantage is great, rivals’ threat of preemption can be considered irrelevant, and that the firm will invest in monopolistic time, ignoring the possibility of rivals’ entry. Practical implications – In a competitive environment, firms need to decide whether the best strategy is to invest earlier, acquiring a competitive advantage over their rivals, or to postpone their investments, to acquire more information and mitigate the eventual consequences of market uncertainties. This work shows how to do it. Originality/value – This is the first work that, by applying real options games, studies the impact of preemption of investment in oligopolistic asymmetric environment in the Brazilian industry of aluminum cans.
Challenging our serological algorithm for celiac disease (CD) diagnosis by the ESPGHAN guidelines

*Corresponding author: Mira Barak, PhD, Central Laboratory of Haifa and Western Galilee, Clalit Health Services, Hataasia 47, Nesher 20300, Haifa, Israel, Phone: +972-4-209093, Fax: +972-4-209094, E-mail: miraba@clalit.org. il Orit Rozenberg, Paul Froom, Maya Grinberg, Dina Reginashvili and Clara Henig: Central Laboratory of Haifa and Western Galilee, Clalit Health Services, Haifa, Israel Avi Pacht: Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa, Israel Aaron Lerner: Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa, Israel; and B. Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel