Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis

Atherosclerosis is the main pathological basis of ischemic cardiovascular and cerebrovascular diseases and has attracted more attention in recent years. Multiple studies have demonstrated that the signal transducer and activator of transcription 3 (STAT3) plays essential roles in the process of atherosclerosis. Moreover, aberrant STAT3 activation has been shown to contribute to the occurrence and development of atherosclerosis. Therefore, the study of STAT3 inhibitors has gradually become a focal research topic. In this review, we describe the crucial roles of STAT3 in endothelial cell dysfunction, macrophage polarization, inflammation, and immunity during atherosclerosis. STAT3 in mitochondria is mentioned as well. Then, we present a summary and classification of STAT3 inhibitors, which could offer potential treatment strategies for atherosclerosis. Furthermore, we enumerate some of the problems that have interfered with the development of mature therapies utilizing STAT3 inhibitors to treat atherosclerosis. Finally, we propose ideas that may help to solve these problems to some extent. Collectively, this review may be useful for developing future STAT3 inhibitor therapies for atherosclerosis.
Safety and efficacy of regional citrate anticoagulation in continuous venovenous hemodialysis in the presence of liver failure : The Liver Citrate Anticoagulation Threshold ( L-CAT )

Introduction: Regional citrate anticoagulation (RCA) for continuous renal replacement therapy is widely used in intensive care units (ICUs). However, concern exists about the safety of citrate in patients with liver failure (LF). The aim of this study was to evaluate safety and efficacy of RCA in ICU patients with varying degrees of impaired liver function. Methods: In a multicenter, prospective, observational study, 133 patients who were treated with RCA and continuous venovenous hemodialysis (RCA-CVVHD) were included. Endpoints for safety were severe acidosis or alkalosis (pH ≤7.2 or ≥7.55, respectively) and severe hypoor hypercalcemia (ionized calcium ≤0.9 or ≥1.5 mmol/L, respectively) of any cause. The endpoint for efficacy was filter lifetime. For analysis, patients were stratified into three predefined liver function or LF groups according to their baseline serum bilirubin level (normal liver function ≤2 mg/dl, mild LF >2 to ≤7 mg/dl, severe LF >7 mg/dl). Results: We included 48 patients with normal liver function, 43 with mild LF, and 42 with severe LF. LF was predominantly due to ischemia (39 %) or multiple organ dysfunction syndrome (27 %). The frequency of safety endpoints in the three patient strata did not differ: severe alkalosis (normal liver function 2 %, mild LF 0 %, severe LF 5 %; p = 0.41), severe acidosis (normal liver function 13 %, mild LF 16 %, severe LF 14 %; p = 0.95), severe hypocalcemia (normal liver function 8 %, mild LF 14 %, severe LF 12 %; p = 0.70), and severe hypercalcemia (0 % in all strata). Only three patients showed signs of impaired citrate metabolism. Overall filter patency was 49 % at 72 h. After censoring for stop of the treatment due to non-clotting causes, estimated 72-h filter survival was 96 %. Conclusions: RCA-CVVHD can be safely used in patients with LF. The technique yields excellent filter patency and thus can be recommended as first-line anticoagulation for the majority of ICU patients. Trial registration: ISRCTN Registry identifier: ISRCTN92716512. Date assigned: 4 December 2008. * Correspondence: torsten.slowinski@charite.de Department of Nephrology, University Hospital Charité, Campus Mitte (CCM), Charitéplatz 1, D-10117 Berlin, Germany Full list of author information is available at the end of the article © 2015 Slowinski et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Slowinski et al. Critical Care (2015) 19:349 Page 2 of 1
Physical Oceanographic Conditions on the Scotian Shelf and in the Gulf of Maine during 2002

A review of physical oceanographic conditions on the Scotian Shelf and in the Gulf of Maine and adjacent offshore areas during 2002 is presented. Warm and salty conditions tended to dominate most of the Scotian Shelf and Gulf of Maine areas in 2002. Mean annual sea-surface temperature at Boothbay Harbor was the 3 warmest in 97 years and at St. Andrews the 9 warmest in 81 years. Particularly warm waters were observed in the Gulf of Maine at all depths in the Bay of Fundy at Prince 5, in Georges Basin, on Georges Bank and on Lurcher Shoals. Where salinity data were available, such as at Prince 5, waters tended to be saltier-than-normal. At Halifax Station 2 (H2) the surface and near bottom layers were warmer-than-usual but at mid-depths they varied through the year between colder and warmer than average. Waters at all depths at H2 tended to exhibit above normal salinities. Similarly warm waters were found in the deepest reaches of Emerald Basin and in the upper 50 to 100 m over Misaine Bank and in Sydney Bight. In these latter two areas, the lower layer waters tended to be on the cold side. Cabot Strait deep-water (200-300 m) temperatures measured on the high side of normal. Exceptions to the warm conditions included the SSTs at both Halifax and over most of the Scotian Shelf during the groundfish survey in July. Subsurface temperatures and salinities on the Shelf varied spatially but tended to be dominated by positive anomalies. There was a noticeable increase in bottom temperatures compared to 2001, however. The vertical stratification in the upper water column (between surface and 50 m) over the Scotian Shelf continued to weaken in 2002 relative to the last few years, and was below normal for the second consecutive year. The annual mean positions of the Shelf/Slope front and the Gulf Stream were similar to those observed in 2001. The Shelf/Slope front was seaward of its normal position while the Gulf Stream was shoreward of its normal position.
The Influences of Institution Governance, Risk Management and Accountability Performance System Implementatation to Fraud Prevention (Studies at Integrated Government Centralized of Banten Province)

These study aim to analysis how influence institution governance, risk management, accountability performance system implementation to preventive of fraud financial management of local government. General purpose this research to explore how are institution governance, risk management and accountability performance system implementation. And special purposes research is hypothesis to testing. The object of research are Banten Province government, with respondent are structural of management on work unit of local government at government center of Banten Provinces. The structure of management which of can be respondent consists of levels II, III, and IV, are number 94 respondent. The results of hypothesis test shows; (1) the institution governance implementation have positive influences to fraud preventive. (b) institution governance implementations have positive influences to accountability performance systems, (c) risk management implementation have negative influences for fraud preventive, (d) risk management have positive influences for accountability performance systems, and (e) accountability performance system have positive influences for fraud prevention. Results of research give theory implication for development public sector accounting knowledge and special develop management accounting public sector, information accounting systems and strategic management accounting. By practice, the results of research have implication to improve finance management system of local government in Indonesia state. For decision maker, the results of research more important to approach judgement risk management in arrangement program and activity plans and public policy decicion making process. The risk approach maybe decision released of conflict of interested and focus to improving continuously, ensure to obey regulation in organizations.
Organo-Modified Vermiculite: Preparation, Characterization, and Sorption of Arsenic Compounds

Among the various technologies tested for removing the anionic species resulting from arsenic contamination, sorption methods have received unflagging interest. Being potential sorbent materials, clay minerals modified by cationic surfactants are often examined for this purpose. Among the clay minerals tested, information regarding sorption properties of expanded vermiculite modified with surfactants is scarce. Therefore, the present study aims to prepare organo-vermiculites modified with hexadecyltrimethylammonium (HDTMA) and benzyldimethylhexadecylammonium (HDBA) at surfactant concentrations of 0.5, 1.0, and 2.0 cation exchange capacity. Modified sorbents were identified and characterized using the analytical methods that can determine phase composition and textural properties of the samples. The sorption of As(III) and As(V) as a function of initial pH value, initial concentration of As(III, V), and initial dosage of sorbent was investigated. The results show that HDTMA and HDBA affect the properties of raw vermiculite. For instance, increase in the concentration of surfactants is often accompanied by a change in interlayer space or textural properties of vermiculite. It was observed that tested organo-minerals adsorbed As(V) to a greater extent compared to As(III). Various analytical studies were carried out and the results revealed the successful synthesis of organo-vermiculite. Moreover, the study also showed that the structure of organo-vermiculite has a significant impact on the uptake of As(III) and As(V) anions.
EVALUATION OF HYPOLIPIDEMIC AND ANTI-OBESITY ACTIVITIES OF MOMORDICA DIOICA ROXB . FRUIT EXTRACTS ON ATHEROGENIC DIET INDUCED HYPERLIPIDEMIC RATS

Cardiovascular diseases are leading cause of death and there is need for development of new therapeutics. Plant based therapeutics play an important role in the management of cardiovascular disease and considering this, the present study was designed to evaluate the antioxidant, hypolipidemic and anti-obesity effect of extracts of Momordica dioica Roxb. fruits (MDR). The crude methanolic extract (MEMD) was prepared by soxhlet extraction and fractionated into petroleum ether, chloroform (NFEMD) and ethyl acetate (FFMD). The marc was macerated with chloroform water to yield the aqueous extract (AEMD). All extracts were evaluated for their in vitro antioxidant and free radical scavenging activities and among the extracts; MEMD & FFMD have shown best antioxidant and free radical scavenging activities. MEMD and FFMD having best activities owing to their high phenolic and flavonoid content were selected for in-vivo studies on atherogenic diet (AD) induced hyperlipidemic rats. Atherogenic diet alone treated animals have developed hyperlipidemia and obesity when compared with normal animals. Whereas MEMD and FFMD significantly (p≤0.05) reduced the elevated levels of total cholesterol (TC), serum triglyceride (TG), LDLcholesterol and VLDLcholesterol, AST and ALT and elevate the decreased level of HDL-cholesterol. Other observations shows that rats treated with MEMD & FFMD underwent a time-dependent reduction in body weight, organ weight and increase in locomotors activity. These results suggest that, MDR extracts possess good hypolipidemic and anti-obesity activity, which may be due to its antioxidant and free radical scavenging potential. MEMD has more potential than FFMD because of high phenolic and flavonoid content.
Sensitivity analysis of Repast

7 Computational ecology is an emerging interdisciplinary discipline founded mainly on modeling and simulation methods for studying ecological systems. Among the existing modeling formalisms, the individual-based modeling is particularly well suited for capturing the complex temporal and spatial dynamics as well as the nonlinearities arising in ecosystems, communities or populations due to individual variability. In addition, being a bottom up approach, it is useful for providing new insights on the local mechanisms which are generating some observed global dynamics. Of course no conclusions about model results could be taken seriously if they are based on a single model execution and they are not analyzed carefully. Therefore, a sound methodology should always be used for underpinning the interpretation of model results. The sensitivity analysis is a methodology for quantitatively assessing the effect of input uncertainty in the simulation output which should be incorporated compulsorily to every work based on in silico experimental setup. In this paper we present R/Repast a GNU R package for running and analyzing Repast Simphony models accompanied by two worked examples on how to perform global sensitivity analysis and how to interpret the results. 8
Alleviation of salinity stress by exogenous plant growth regulators in three citrus rootstocks

A pot experiment was conducted during two growing seasons to determine the effect of foliar sprayed with abscisic acid (ABA) at 10 μM, gibberellic acid (GA) at 100 ppm, paclobutrazol (PBZ) at 250 ppm and salicylic acid (SA) at 1000 ppm on growth rate, total chlorophyll content, leaf catalase (CAT) activity, proline content and leaf Na and Cl contents of three citrus rootstocks namely sour orang, Volkamer lemon and Macrophylla lemon grown under salt stress and greenhouse conditions. Salinity treatments were achieved by irrigating each seedling twice a week with saline solution contained 0, 2000 and 4000 ppm NaCl. Salinity stress negatively affected rootstocks growth rate, chlorophyll content and catalase activity of citrus rootstocks whereas leaf proline content, leaf Na and Cl contents increased. Rootstocks treated with each of SA and ABA treatments significantly had greater growth rate, chlorophyll content, proline content and catalase activity under salt stress. Abscisic acid and salicylic acid treatments tended to decrease the concentrations of leaf Na and Cl. These findings suggested that the ABA and SA treatments can enhanced the negative effects of salinity stress on the growth of these three citrus rootstock seedlings.
econstor Make Your Publications Visible . A Service of zbw

I introduce a model of undirected dyadic link formation which allows for assortative matching on observed agent characteristics (homophily) as well as unrestricted agent level heterogeneity in link surplus (degree heterogeneity). Like in fixed effects panel data analyses, the joint distribution of observed and unobserved agent-level characteristics is left unrestricted. Two estimators for the (common) homophily parameter, β0, are developed and their properties studied under an asymptotic sequence involving a single network growing large. The first, tetrad logit (TL), estimator conditions on a sufficient statistic for the degree heterogeneity. The second, joint maximum likelihood (JML), estimator treats the degree heterogeneity {Ai0}Ni=1 as additional (incidental) parameters to be estimated. The TL estimate is consistent under both sparse and dense graph sequences, whereas consistency of the JML estimate is shown only under dense graph sequences. JEL Codes: C31, C33, C35
Achieving WIL placement and theoretical learning concurrently: An online strategy for Higher Education Institutions

The Australian Government requires Higher Education Institutions to demonstrate the work-readiness of graduates. Consequently, Work Integrated Learning (WIL) has been adopted to enhance the workplace skills and professional networks of students to improve graduate employability. While WIL can take many forms, experiences located in workplaces (placements, internships) have been popular. The introduction of the Australian Government’s Fair Work Act 2009 required that placements be tightly embedded within curriculum thereby presenting the challenge of how to enable WIL via placements and theoretical learning in already compact study programs. As a response, we present the pragmatic use of online theoretical instruction and online WIL assessment within an undergraduate core Capstone business subject, as an enabler of the WIL placement. We examine learner perspectives on, and grade outcomes from, undertaking online theoretical instruction concurrent with WIL placements to discuss the key WIL and online learning design implications for this cohort of learners. Our findings are increasingly pertinent given the 2017 Australian Government Higher Education Reform package incentivising the expansion of WIL into all degrees.
Relationship Between Nutritional Status And Classification For Cough Or Difficult Breathing Of Children Under Five Years In Community Health Center Of Piyungan

Cough or difficulty breathing is a common problem that causes the increased rate of mortality and morbidity in children under five years old. According to the chart of Integrated Management of Childhood Illness (IMCI) in 2015 shows cough or difficulty breathing is classify into three, there are cough or cold no pneumonia, pneumonia, and severe pneumonia. Nutritional status of children is important to forming body immune, especially in preventing infection. Malnutrition in children is vulnerable to various infections. Determining the relationship between nutritional status of children under five years old and cough or difficult breathing classification based IMCI in Community Health Center of Piyungan Bantul Yogyakarta Indonesia. The study was a descriptive correlational retrospective approach. Sampling technique was used simple random sampling. Subjects in this study were children under five years old and cough or difficult breathing classification based IMCI ISSN 2354-7642 (Print), ISSN 2503-1856 (Online) Jurnal Ners dan Kebidanan Indonesia Tersedia online pada: http://ejournal.almaata. ac.id/index.php/JNKI INDONESIAN JOURNAL OF NURSING AND MIDWIFERY
A Personalized Threshold Method via Boosting for Sepsis Screening

Sepsis is one of the biggest risks to patient safety, with a natural mortality rate between 25% and 50%. It is difficult to diagnose and no validated standard for diagnosis currently exists. A commonly used scoring criteria is the quick sequential organ failure assessment (qSOFA). It has been shown to have low sensitivity in practice, however. We develop a method to personalize thresholds in qSOFA that incorporates easy to measure patient baseline characteristics. We compare the personalized threshold method to qSOFA, five previously published methods that obtain an optimal constant threshold for a single biomarker, and to the machine learning algorithms based on logistic regression and AdaBoosting using patient data in the MIMIC-III database. The personalized threshold method achieves higher accuracy than qSOFA and the five published methods and has comparable performance to machine learning methods. Personalized thresholds, however, are much easier to adopt in practice than machine learning methods as they are computed once for a patient and used in the same way as qSOFA, whereas the machine learning methods require an update after each observation.
Johns Hopkins University Submission for WMT News Translation Task

We describe the work of Johns Hopkins University for the shared task of news translation organized by the Fourth Conference on Machine Translation (2019). We submitted systems for both directions of the English-German language pair. The systems combine multiple techniques – sampling, filtering, iterative backtranslation, and continued training – previously used to improve performance of neural machine translation models. At submission time, we achieve a BLEU score of 38.1 for De-En and 42.5 for En-De translation directions on newstest2019. Post-submission, the score is 38.4 for De-En and 42.8 for En-De. Various experiments conducted in the process are also described.
The Price of Safety: The Evolution of Municipal Bond Insurance Value

Economic theory predicts that bond insurance lowers issuers’ financing costs by resolving asymmetric information and mitigating credit risk. With comprehensive data over the last 36 years, we find increasingly diminished empirical support for these models. The value of insurance in resolving asymmetric information beyond that resolved by credit ratings and other observable bond characteristics is economically minimal. The average gross value of insurance ranges from 4 to 14 bps when bond insurers offer Aaa-rated coverage. However, this gross value becomes insignificant after 2008 when Aaa-rated insurance no longer exists. Evidence suggests that the lack of insurance benefit in the postcrisis period is attributable to the deteriorated creditworthiness of insurance companies. Examining noninterest saving explanations for the continued use of insurance in the no-Aaa insurance market, we find evidence that issuers purchase insurance out of habit (with insurance value most diminished for habitual purchasers with low governance quality) and for the convenience it affords in default, but no evidence that insurance improves secondary market liquidity. This paper was accepted by Gustavo Manso, finance. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023. 4813 .
Fatty Liver Index is a Sensitive and Specific Marker of Non Alcoholic Fatty Liver Disease Measured by Transient Elastography in a Cohort of HIV Mono-Infected Patients

Indeed metabolic disorder have become one of the principal concern in the management of HIV patients: presence of metabolic syndrome, which promotes NAFLD, increased in HIV-infected patients from 19.4% in 2000–2001 to 41.6% in 2006–2007 [5,6]. Few data studied the prevalence of NAFLD among HIV monoinfected patients, which is reported higher than in general population and varies between 31%-37% [7].
Clinical Reasoning and Utilization of a Literature Review during the Management of Patellofemoral Syndrome: A Case Report

Introduction: Evidenced based practice is grounded upon the integration of current literature and clinical practice. Throughout the musculoskeletal management of a patient, clinical questions can be answered based on current research. Patellofemoral pain syndrome (PFPS) is a common condition with a reported incidence of 20-40% of all knee cases in sports medicine clinics. The purpose of this case report is to demonstrate how a literature review can enhance clinical reasoning during the management of the patient/client with PFPS. Case Description: 17 year old male football player with chief complaint of bilateral anterior knee pain (Right>Left) with activity limitation of squatting, running, and jumping. Methods: A literature search in Medline & CINAHL was conducted reviewing abstracts focusing on movement assessments identify dysfunctional movement patterns and individuals at risk for injuries; and movement assessment assisting in developing prognosis and plan of care. The review of literature revealed 15 articles that were deemed appropriate. Conclusion: PFPS is a common musculoskeletal condition facing today’s clinician. The challenge for clinician’s within the current healthcare environment stem from the fact PFPS is a mutifactorial issue with no definitive diagnostic criteria, and limited clinical utility of impairment based clinical tests have provided minimal information that can assist the clinician in managing patients with this condition. Movement assessments are potential alternatives from isolated impairment based tests that can enhance clinical reasoning by capturing regional interdependence implications