Miracle-dz/UniFAR-FTUs huggingface dataset:
A Pilot Study Evaluating the Safety and Efficacy of OP-1 Putty (rhBMP-7) as a Replacement for Iliac Crest Autograft in Posterolateral Lumbar Arthrodesis for Degenerative Spondylolisthesis

Study Design. A prospective, randomized, controlled, multicenter clinical study was conducted. Objective. To compare the clinical and radiographic outcomes of patients treated with OP-1 (BMP-7) Putty to autogenous iliac crest bone graft for one-level uninstrumented posterolateral fusion of the lumbar spine following decompressive laminectomy for the treatment of symptomatic degenerative spondylolisthesis with spinal stenosis. Background. Preclinical studies have demonstrated that osteoinductive recombinant human osteogenic protein1 in the form of OP-1 Putty is successful at achieving a posterolateral fusion in rabbits and dogs without any significant safety concerns. Methods. Thirty-six patients with degenerative lumbar spondylolisthesis and symptoms of neurogenic claudication were randomized (2:1) to either OP-1 Putty (3.5 mg of OP-1 per side) or autogenous iliac crest bone graft for one-level uninstrumented posterolateral fusion following a decompressive laminectomy. Enrollment in the study was complete when 24 OP-1 Putty patients and 12 autograft patients had been randomized and treated. A patient administered Oswestry scale and SF-36 scale were used to determine clinical outcomes. Independent, blinded neuroradiologists reviewed both static and dynamic radiographs to determine fusion status. Results. At the 1-year follow-up, 32 patients were available for clinical analysis and 29 patients were available for radiographic review. Clinical success as measured on the Oswestry scale was achieved by 18 of 21 (86%) OP-1 Putty patients and 8 of 11 (73%) autograftpatients. SF-36 pain index scores showed similar results. Fourteen of 19 (74%) OP-1 Putty patients and 6 of 10 (60%) autograft patients achieved a successful posterolateral fusion fulfilling all fusion criteria. Of the 29 evaluable patients, 15 were both clinical and radiographic successes, 5 were radiographic successes but were clinicalfailures, 1 patient was both a radiographic and clinical failure, and 8 patients were radiographic failures but were clinical successes. No systemic toxicity, ectopic bone formation, recurrent stenosis, or other adverse events related to the OP-1 Putty implant were observed. Conclusion. Although the posterolateral spine is a challenging fusion environment in patients with degenerative spondylolisthesis, successful radiographic fusion was obtained using OP-1 Putty at a rate that was similar to autograft given the number of patients in this study. Importantly, there were no apparent adverse consequences related to the use of the OP-1 Putty implant in this patient population.
Fingolimod impedes Schwann cell-mediated myelination: implications for the treatment of immune neuropathies?

BACKGROUND Fingolimod (FTY720), a first-in-class sphingosine-1-phosphate (S1P) receptor agonist, is a recently approved drug for treating relapsing multiple sclerosis. Experimental evidence suggests that FTY720 not only exhibits anti-inflammatory properties but also promotes myelination in the central nervous system by direct interaction with oligodendrocytes. OBJECTIVE To assess the effects of FTY720 on Schwann cells (SCs) and peripheral nerve myelination. DESIGN Receptor expression studies and myelination were investigated in primary rat SCs and rat neuronal/SC cocultures. Cells were treated with physiologically relevant concentrations of the active phosphorylated form of FTY720 (FTY720P). In addition, S1P receptor expression was corroborated in human and rat peripheral nerve tissue sections. RESULTS Schwann cells express all known S1P receptors on the RNA level, not altered by FTY720P. In the myelination model, treatment with FTY720P resulted in a significant reduction of quantitative myelin formation. FTY720P induced reactive oxygen species in SCs associated with apoptosis of these cells, as demonstrated by the detection of cysteine aspartic acid–specific protease 3 and 7, as well as terminal deoxynucleotidyl transferase dUTP nick-end labeling. This effect was dependent of S1P signaling because the blocking of S1P receptors ameliorated reactive oxygen species production, SC apoptosis, and myelin loss. CONCLUSIONS FTY720P at greater concentrations induces apoptosis in SCs and may interfere with peripheral nerve myelination.
Evaluating Alternative Methods of Forecasting House Prices: A Post-Crisis Reassessment

This paper compares the performance of different forecasting models of California house prices. Multivariate, theory-driven models are able to outperform a theoretical time series models across a battery of forecast comparison measures. Error correction models were best able to predict the turning point in the housing market, whereas univariate models were not. Similarly, even after the turning point occurred, error correction models were still able to outperform univariate models based on MSFE, bias, and forecast encompassing statistics and tests. These results highlight the importance of incorporating theoretical economic relationships into empirical forecasting models.
Phosphatidylserine-Containing Liposomes Inhibit the Differentiation of Osteoclasts and Trabecular Bone Loss

Liposomes containing phosphatidylserine (PS) are engulfed by phagocytes including macrophages, microglia, and dendritic cells. PS liposomes (PSLs) mimic the effects of apoptotic cells on these phagocytes to induce the secretion of anti-inflammatory molecules and to inhibit the maturation of dendritic cells. However, the effects of PSLs on osteoclasts, which are also differentiated from the common myeloid precursors, remain to be determined. This study investigated the effects of PSLs on the osteoclastogenesis. In the rat bone marrow culture system, osteoclast precursors phagocytosed PSLs to secrete TGF-β1 and PGE2, which in turn inhibited osteoclastogenesis through the downregulation of receptor activator for NF-κB ligand, receptor activator of NF-κB, ICAM-1, and CD44. Consistent with these in vitro observations, i.m. injection of PSLs significantly increased the plasma level of TGF-β1 and PGE2 and decreased the expression of receptor activator for NF-κB ligand, receptor activator of NF-κB, and ICAM-1 in the skeletal tissues of ankle joints of rats with adjuvant arthritis (AA). A quantitative analysis using microcomputed tomography revealed that PSLs as well as TGF-β1 together with PGE2 significantly inhibited AA-induced trabecular bone loss. These observations strongly suggest that PSLs generate TGF-β1 and PGE2 release, leading to inhibit osteoclastogenesis and AA-induced trabecular bone loss. Because PS is a component of the cell membrane, PSLs therefore can be a potentially effective pharmacological intervention against abnormal bone loss, such as osteoporosis without deleterious side effects.
Activation of frontoparietal cortices during memorized triple‐step sequences of saccadic eye movements: an fMRI study

To determine the cortical areas controlling memory‐guided sequences of saccadic eye movements, we performed functional magnetic resonance imaging (fMRI) in six healthy adults. Subjects had to perform a memorized sequence of three saccades in darkness, after a triple‐step stimulus of successively flashed laser targets. To assess the differential contribution of saccadic subfunctions, we applied several control conditions, such as central fixation with or without triple‐step visual stimulation, self‐paced saccades in darkness, visually guided saccades and single memory‐guided saccades. Triple‐step saccades strongly activated the regions of the frontal eye fields, the adjacent ventral premotor cortex, the supplementary eye fields, the anterior cingulate cortex and several posterior parietal foci in the superior parietal lobule, the precuneus, and the middle and posterior portion of the intraparietal sulcus, the probable location of the human parietal eye field. Comparison with the control conditions showed that the right intraparietal sulcus and parts of the frontal and supplementary eye fields are more involved in the execution of triple‐step saccades than in the other saccade tasks. In accordance with evidence from clinical lesion studies, we propose that the supplementary eye field essentially controls the triggering of memorized saccadic sequences, whereas activation near the middle portion of the right intraparietal sulcus appears to reflect the necessary spatial computations, including the use of extraretinal information (efference copy) about a saccadic eye displacement for updating the spatial representation of the second or third target of the triple‐step sequence.
Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

To understand the system of secreted proteins and receptors involved in cell-cell signaling, we produced a comprehensive set of recombinant secreted proteins and the extracellular domains of transmembrane proteins, which constitute most of the protein components of the extracellular space. Each protein was tested in a suite of assays that measured metabolic, growth, or transcriptional responses in diverse cell types. The pattern of responses across assays was analyzed for the degree of functional selectivity of each protein. One of the highly selective proteins was a previously undescribed ligand, designated interleukin-34 (IL-34), which stimulates monocyte viability but does not affect responses in a wide spectrum of other assays. In a separate functional screen, we used a collection of extracellular domains of transmembrane proteins to discover the receptor for IL-34, which was a known cytokine receptor, colony-stimulating factor 1 (also called macrophage colony-stimulating factor) receptor. This systematic approach is thus useful for discovering new ligands and receptors and assessing the functional selectivity of extracellular regulatory proteins.
Analysis of the individual regulatory components of the IncFII plasmid replication control system

Replication of the IncFII plasmid NR1 is controlled by regulating the amount of synthesis of the repA1 initiator protein at both the transcriptional and translational levels. We have examined mutations which have altered each of these levels of regulation, resulting in different plasmid copy numbers. The genes which encode each of the individual wild-type or mutant regulatory components from the replication control region of NR1 have been cloned independently into pBR322 vectors, and their effects in trans, either individually or in various combinations, on plasmid incompatibility, stability, copy number, and repA1 gene expression have been defined.
Family history of depression and therapeutic outcome: findings from STAR*D.

OBJECTIVE It is unclear whether a positive family history of depression affects the clinical presentation or effectiveness of treatment for major depressive disorder (MDD). We aimed to determine whether depressed patients with a positive family history of depression differed from those without in terms of baseline sociodemographic and clinical characteristics, including concurrent comorbid conditions and treatment outcome with citalopram in a large, multicenter effectiveness trial. METHOD Clinical outcome and sociodemographic information were collected on 2876 participants with DSM-IV MDD enrolled from July 2001 through April 2004 in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Participants with and without a family history of depression, as determined by self-report at initial assessment, were compared. RESULTS Over half (55.6%) (1585/2853) of the evaluable sample reported a positive family history of depression. A positive family history of depression was associated with an earlier age at onset of MDD, a longer length of illness, and more comorbid generalized anxiety disorder and prior suicide attempts. These participants had a slightly faster onset of remission, and slightly greater side effect burden, but they did not differ overall in response or remission rates. CONCLUSIONS A family history of depression was associated with several clinical characteristics, although its usefulness as a predictor of treatment outcome is questionable. The slightly faster remission with an SSRI despite the slightly greater side effect burden indicates the effectiveness of using an SSRI in treating depressed patients both with and without a family history of depression. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00021528.
Cohort Variation in Happiness: Some Hypotheses and Exploratory Analyses

Research on historical and age differences in well-being suggests that cohort factors explain at least part of the variation in adults' reports of well-being. Theoretical arguments suggest that it is the bases of people's evaluations of their well-being that reflect the characteristic socializing influences of their cohort. Portraits of two cohorts of older adults are drawn from historical and sociological sources and hypotheses about cohort-specific values are tested with data collected by Veroff and his colleagues in 1957 and 1976. Findings do not support the idea that happiness among the adults who produced the post-World War II baby boom is uniquely linked to concerns with marriage and children. Results do provide partial support for the view that adults born before 1900 are distinctive from other cohorts in that their happiness levels are more closely linked with survival needs and more firmly wedded to Protestant ethic values.
Postnatal depression in the community.

BACKGROUND Postnatal depression affects 15% of all women derived. Good practice in antenatal and postnatal care suggests that regular contact should take place with members of the primary health care team (PHCT) but, despite this, many cases of postnatal depression are probably not detected. It is also widely perceived that depressed women consult more frequently about themselves and their babies, but it is not clear whether the number of contacts with the primary health care team as a whole reflects this. AIM To determine whether the use of the Edinburgh Postnatal Depression Scale (EPNDS) at postnatal examination would detect women not recognized as depressed by the PHCT. To determine whether the number of contacts with the PHCT could be used as a screening tool for postnatal depression. METHOD The EPNDS was administered at postnatal examination to 176 women delivering their babies between 1 April 1995 and 31 October 1995. Contacts with PHCT members were recorded up to the 42nd day after delivery, together with their assessment of the subjects' mental health. RESULTS Of 30 women scoring > or = 12 on the EPNDS, only 13 were perceived to be depressed by the PHCT. The team as a whole identified more depressed women than any individual professional group. There was no significant difference in the number of contacts made with professionals by women who were or were not depressed. Asian women were more likely to be depressed than women from other ethnic groups. CONCLUSION Despite the PHCT as a whole identifying more depressed women than any individual group, more than half were not identified by professionals. Tools such as the EPNDS should be used routinely in primary care; there is an urgent need to validate the EPNDS for non-Caucasian women.
Soluble adhesion molecules in acute ischemic stroke.

BACKGROUND Inflammatory adhesion molecules play a key role in the development of ischemic lesions. Elevated plasma concentrations of soluble adhesion molecules are reported in stroke patients, but data are still controversial. Our aim was to explore the potential association of plasma levels of soluble (s) intercellular and vascular cellular adhesion molecules-1 (sICAM-1 and sVCAM-1), sE-selectin and sL-selectin with acute ischemic stroke. METHODS At our university hospital in Zagreb, Croatia, we prospectively enrolled 67 subjects with acute ischemic stroke, as well as 76 consecutive healthy individuals as controls who were visiting the centre for reasons unrelated to stroke. Serum concentrations of the molecules of interest were determined by means of quantitative sandwich enzyme immunoassay. RESULTS Mean levels of sICAM-1 (p < 0.001), sVCAM-1 (p < 0.034) and sE-selectin (p < 0.002) were higher in patients than in controls, whereas sL-selectin was lower in patients (p = 0.043). In patients, levels of soluble adhesion molecules were independent of age and sex except for sL-selectin, which was inversely correlated with age (r = -0.260, p = 0.034) and higher in women (p = 0.006) and diabetics (n = 14; p = 0.004). Serum levels did not differ significantly with respect to carotid atherosclerotic disease, smoking status, hypertension or hypercholesterolemia. As well as correlating with each other, concentrations of soluble adhesion molecules in patients correlated with traditional biochemical markers of inflammation: total leukocyte count, erythrocyte sedimentation rate (ESR) and C-reactive protein level. Concentrations of sICAM-1 and high-density lipoprotein-cholesterol and ESR were identified as significant independent predictors/indicators of acute ischemic stroke. CONCLUSIONS Acute ischemic stroke is associated with elevated plasma levels of sICAM-1, sVCAM-1 and sE-selectin, independent of age, sex and other recognized risk factors for stroke. Decreased levels of sL-selectin are associated with acute stroke. The observed changes in serum concentrations of adhesion molecules indicate inflammatory process occurring during acute cerebral ischemia.
A 3-D Printed Lightweight X-Band Waveguide Filter Based on Spherical Resonators

A fifth order X-band waveguide bandpass filter, based on spherical resonators, has been designed, and fabricated by 3-D printing. In comparison with rectangular waveguide, spherical resonators have a higher unloaded quality factor, but at the same time suffer from closer higher order modes. In this letter, a special topology has been proposed to relieve the impact of the first three higher order modes in the resonator and ultimately to achieve a good out-of-band rejection. Stereolithography based 3-D printing is used to build the filter structure from polymer and a 25 μm thick copper layer is deposited to the filter. The measurement result of the filter has an excellent agreement with the simulations. The filter is also considerably lighter than a similar metal filter.
Consistent k-Clustering

The study of online algorithms and competitive analysis provides a solid foundation for studying the quality of irrevocable decision making when the data arrives in an online manner. While in some scenarios the decisions are indeed irrevocable, there are many practical situations when changing a previous decision is not impossible, but simply expensive. In this work we formalize this notion and introduce the consistent k-clustering problem. With points arriving online, the goal is to maintain a constant approximate solution, while minimizing the number of reclusterings necessary. We prove a lower bound, showing that Ω(k log n) changes are necessary in the worst case for a wide range of objective functions. On the positive side, we give an algorithm that needs onlyO(k log n) changes to maintain a constant competitive solution, an exponential improvement on the naive solution of reclustering at every time step. Finally, we show experimentally that our approach performs much better than the theoretical bound, with the number of changes growing approximately as O(log n).
Trust Management for Public Key Infrastructures: Implementing the X.509 Trust Broker

A Public Key Infrastructure (PKI) is considered one of the most important techniques used to propagate trust in authentication over the Internet. This technology is based on a trust model defined by the original X.509 (1988) standard and is composed of three entities: the certification authority (CA), the certificate holder (or subject), and the Relying Party (RP). The CA plays the role of a trusted third party between the certificate holder and the RP. In many use cases, this trust model has worked successfully. However, we argue that the application of this model on the Internet implies that web users need to depend on almost anyone in the world in order to use PKI technology. Thus, we believe that the current TLS system is not fit for purpose and must be revisited as a whole. In response, the latest draft edition of X.509 has proposed a new trust model by adding new entity called the Trust Broker (TB). In this paper, we present an implementation approach that a Trust Broker could follow in order to give RPs trust information about a CA by assessing the quality of its issued certificates. This is related to the quality of the CA’s policies and procedures and its commitment to them. Finally, we present our Trust Broker implementation that demonstrates how RPs can make informed decisions about certificate holders in the context of the global web, without requiring large processing resources themselves.
Graph Visualization Toolkits

The authors have created two toolkits that allow developers to easily integrate graph visualization capabilities into custom software applications. The Graph Layout Toolkit (GLT) provides interfaces for modeling, drawing, and automatically laying out graphs. The Graph Editing Toolkit (GET) provides a customizable display and editing layer, which facilitates rapidly developing tools that visualize data in the form of graphs. The authors present an architectural overview of these tools and discuss the challenges encountered during implementation and integration of theory and research results into such tools, In particular, they discuss automatic graph layout and labeling algorithms and complexity management techniques. In addition, they present examples of applications using these tools.
Functional status versus utilities in survivors of myocardial infarction.

While much progress in assessing quality of life has been made since Karnofsky'sseminal effort,1 the plethora of instruments2 is an indication of the lack of a gold standard in the field. Types of measures include ordinal symptom and functional status scales, such as the Karnofsky scale,1'3 rating scales such as the 10 cm visual analogue scale,4 and utilities, such as the time trade-off,5 which gauge a person's strength of preference for their health state. Although comparisons have been made among functional status measures6-10 and among utility measures,11-14 utilities have rarely been directly compared with functional status measures.7'13'516 The purposes of this study were: 1) to assess the
Self-concept and the perception of facial appearance in children and adolescents seeking orthodontic treatment.

OBJECTIVE To examine, in adolescents with mild to moderate malocclusion, the relationship between self-concept and demographic characteristics, a clinical assessment of malocclusion, self-perception of malocclusion, and self-perception of facial attractiveness. METHODS AND MATERIALS Fifty-nine consecutive patients ages 9 to 15 years scheduled for initial records in a graduate orthodontic clinic consented to participate. Each subject independently completed the Multidimensional Self-Concept Scale (MSCS), the Facial Image Scale, and the Index of Treatment Need-Aesthetic Component (IOTN-AC). Peer Assessment Rating (PAR) scores were obtained from the patients' diagnostic dental casts. Forward multiple-regression analysis with a backward overlook was used to analyze the effect of the demographic, clinical, and self-perception measures on each of the six self-concept (MSCS) domains. RESULTS Self-perception of the dentofacial region was the only statistically significant predictor (P < .05) for the Global, Competence, Affect, Academic, and Physical domains of self-concept, while age, parental marital status, and the adolescent's self-perception of the dentofacial region were statistically significant predictors (P < .05) of Social Self-Concept. CONCLUSION The self-perceived level of the attractiveness or "positive" feelings toward the dentofacial region is more strongly related to self-concept than the severity of the malocclusion as indicated by the PAR score or by the adolescent's perception of their malocclusion.