Miracle-dz/UniFAR-FTUs huggingface dataset:
Supraventricular escape rhythms during transient episodes of bradycardia in preterm infants

Objective: To evaluate the origin of transient episodes of sinus bradycardia, atrial escape rhythm, and atrioventricular nodal escape rhythm in preterm infants. Material and methods: The study was observational, and was carried out in a third level neonatal intensive care unit. We studied 19 spontaneously breathing infants born healthy but prior to term, the examinations being carried out between the ages of 3 and 28 days. The mean gestational age was 29.2 ± 1.9 weeks, and the mean birth weight was 1154 ± 264 g. Transient episodes of bradycardia were defined as a decline in heart rate equal to or greater than 25% from baseline, lasting for at least 3 successive RR-intervals. To discriminate between different types of escape mechanisms, we used the P wave and the P axis of the electrocardiogram. Sinus bradycardia was diagnosed when the P axis was from +0 to +90 degrees; atrial escape rhythm when it was from +91 to +359 degrees, and atrioventricular nodal escape rhythm when the P wave was absent, hidden, or followed the QRS complex. Results: The mean P axis was +50 ± 11 degrees. We observed 60 transient episodes of bradycardia in 11 of the 19 infants. Of these, 34 (57%) were classified as sinus bradycardia, and 13 (22%) as atrial escapes. Atrioventricular nodal escapes developed during 6 episodes (10%), while 7 episodes (11%) could not be classified. Conclusions: Atrial excitation as evidenced by the P axis during sinus rhythm is similar in very preterm infants to that seen in children and adults. Escape rhythms with different origins occur during transient episodes of bradycardia in healthy preterm infants. In at least one third, the episodes are due to atrial or atrioventricul ar nodal escape.
Assessment of pulmonary microstructural changes by hyperpolarized 129Xe diffusion-weighted imaging in an elastase-instilled rat model of emphysema.

BACKGROUND The purpose of this study was to explore the feasibility of hyperpolarized 129Xe diffusion-weighted imaging (DWI) for the evaluation of pulmonary microstructural changes in the presence of pancreatic porcine elastase (PPE)-induced pulmonary emphysema rat model. METHODS Sixteen male Sprague-Dawley (SD) rats were randomly divided into two groups, the emphysema model group and control group. Experimental emphysematous models were made by instilling elastase into rat lungs of model group, the control group were instilled with isodose saline. Hyperpolarized 129Xe magnetic resonance imaging (MRI) and histology were performed in all 16 rats after 30 days. DWIs were performed on a Bruker 7.0 T micro MRI, and the apparent diffusion coefficients (ADCs) were measured in all rats. Mean linear intercepts (MLIs) of pulmonary alveoli were measured on histology. The statistical analyses were performed about the correlation between the mean ADC of hyperpolarized 129Xe in the whole lung and MLI of pulmonary histology metric. RESULTS The pulmonary emphysematous model was successfully confirmed by the histology and all scans were also successful. The ADC value of 129Xe in the model group (0.0313±0.0005 cm2/s) was significantly increased compared with that of the control group (0.0288±0.0007 cm2/s, P<0.0001). Morphological differences such as MLI of pulmonary alveoli were observed between the two groups, the MLI of pulmonary alveoli in model group significantly increased (91±5 µm) than that of control group (50±3 µm, P<0.0001). Furthermore, the ADCs was moderately correlated with MLIs (r=0.724, P<0.01). CONCLUSIONS These results indicate that 129Xe ADC value can quantitatively reflect the alveolar space enlargement and it is a promising biomarker for the detection of pulmonary emphysema.
Actin Binding GFP Allows 4D In Vivo Imaging of Myofilament Dynamics in the Zebrafish Heart and the Identification of Erbb2 Signaling as a Remodeling Factor of Myofibril Architecture

Rationale: Dilated cardiomyopathy is a leading cause of congestive heart failure and a debilitating complication of antineoplastic therapies. Despite disparate causes for dilated cardiomyopathy, maladaptive cardiac remodeling and decreased systolic function are common clinical consequences, begging an investigation of in vivo contractile dynamics in development and disease, one that has been impossible to date. Objective: To image myocardial contractile filament dynamics in vivo and to assess potential causes of dilated cardiomyopathy in antineoplastic therapies targeting the epidermal growth factor receptor Erbb2. Methods and Results: We generated a transgenic zebrafish line expressing an actin-binding green fluorescent protein in cardiomyocytes, allowing an in vivo imaging of myofilaments. Analysis of this line revealed architectural differences in myofibrils of the distinct cardiomyocyte subtypes. We used this model to investigate the effects of Erbb2 signaling on myofibrillar organization because drugs targeting ERBB2 (HER2/NEU) signaling, a mainstay of breast cancer chemotherapy, cause dilated cardiomyopathy in many patients. High-resolution in vivo imaging revealed that Erbb2 signaling regulates a switch between a dense apical network of filamentous myofibrils and the assembly of basally localized myofibrils in ventricular cardiomyocytes. Conclusions: Using this novel line, we compiled a reference for myofibrillar microarchitecture among myocardial subtypes in vivo and at different developmental stages, establishing this model as a tool to analyze in vivo cardiomyocyte contractility and remodeling for a broad range of cardiovascular questions. Furthermore, we applied this model to study Erbb2 signaling in cardiomyopathy. We show a direct link between Erbb2 activity and remodeling of myofibrils, revealing an unexpected mechanism with potentially important implications for prevention and treatment of cardiomyopathy.
Can motor control training lower the risk of injury for professional football players?

PURPOSE Among injuries reported by the Australian Football League (AFL), lower limb injuries have shown the highest incidence and prevalence rates. Deficits in the muscles of the lumbopelvic region, such as a smaller size of multifidus (MF) muscle, have been related to the occurrence of lower limb injuries in the preseason in AFL players. Motor control training programs have been effective in restoring the size and control of the MF muscle, but the relationship between motor control training and occurrence of injuries has not been extensively examined. METHODS This pre- and postintervention trial was delivered during the playing season as a panel design with three groups. The motor control program involved voluntary contractions of the MF, transversus abdominis, and pelvic floor muscles while receiving feedback from ultrasound imaging and progressed into a functional rehabilitation program. Assessments of muscle size and function were performed using magnetic resonance imaging and included the measurement of cross-sectional areas of MF, psoas, and quadratus lumborum muscles and the change in trunk cross-sectional area due to voluntarily contracting the transversus abdominis muscle. Injury data were obtained from club records. Informed consent was obtained from all study participants. RESULTS A smaller size of the MF muscle (odds ratio [OR] = 2.38) or quadratus lumborum muscle (OR = 2.17) was predictive of lower limb injury in the playing season. At the time point when one group of players had not received the intervention (n = 14), comparisons were made with the combined groups who had received the intervention (n = 32). The risk of sustaining a severe injury was lower for those players who received the motor control intervention (OR = 0.09). CONCLUSION Although there are many factors associated with injuries in AFL, motor control training may provide a useful addition to strategies aimed at reducing lower limb injuries.
MEASUREMENT INVARIANCE OF A REFINED VALUES SCALE 1 Running Head : MEASUREMENT INVARIANCE OF A REFINED VALUES SCALE The Cross-National Invariance Properties of a New Scale to Measure 19 Basic Human Values . A Test across Eight Countries

Several studies that measured basic human values across countries with the Portrait Values Questionnaire (PVQ-21) reported violations of measurement invariance. Such violations may hinder meaningful cross-cultural research on human values because value scores may not be comparable. Schwartz et al. proposed a refined value theory and a new instrument (PVQ-5X) to measure 19 more narrowly defined values. We tested the measurement invariance of this instrument across eight countries. Configural and metric invariance were established for all values across almost all countries. Scalar invariance was supported across nearly all countries for 10 values. The analyses revealed that the cross-country invariance properties of the values measured with the PVQ-5X are substantially better than those measured with the PVQ-21.
Association of molecular variants of luteinizing hormone with menstrual disorders

Luteinizing hormone (LH) promotes ovulation and luteinization of the ovarian follicle, and stimulates steroidogenesis in the ovaries. It is known to be present in different molecular forms, and secretion of abnormal LH has been implicated in menstrual disorders and infertility. The purpose of this study was to determine any association of two recently described LH variants with menstrual disorders in Singapore Chinese women. One of these variants had Trp8 to Arg8 and Ile15 to Thr15 replacements in the LH β‐subunit, while the second variant possessed Ser102 substitution for Gly102.
The Occurrence of Diseases and Related Factors in a Center for Asylum Seekers in Italy

Abstract Introduction Italy is the main recipient of asylum seekers in the European region, and Sicily is their first point of arrival. This geographical position creates a large job for Health Authorities to identify and deal with the health of immigrants. This study evaluates the prevalence of disease among asylum seekers, assessing which are associated factors. Methods A cross-sectional study was conducted to analyse demographic and clinical data in an Acceptance Centres for Asylum Seekers from February 2012 to May 2013. All variables that were found to be significant on unvariable analysis for the most frequent pathologies were included in a multivariable logistic regression model. Results Post-traumatic stress disorders with 17.4% and major depression with 7.3% were the most frequent diseases. The factors associated with post-traumatic stress disorders among asylum seekers were: major depression diagnosis (OR=2.91, p=0.004), Pakistan as a country of origin (OR=3.88, p <0.001), the largest number of medical visits (OR=1.02, p=0.033) and refugee status (OR=1.97, p=0.036). The variables linked with the diagnosis of major depression from the multivariable analysis were: suffering from post-traumatic stress disorders (OR=3.83, p <0.001), Pakistan as a country of origin (OR=3.45, p=0.004) and the highest number of visits to psychologist (OR=1.15, p <0.001). Conclusions The mental wellbeing of asylum seekers needs special attention, and interventions should be done to prevent the consolidation of psychiatric morbidity. A short psychological screening after the arrival might prove helpful here. Moreover, carefully designed longitudinal studies should be carried out when political recommendations try to change the organization of psychological and healthcare services.
Molecular characterization of Duck Plague virus isolated from Bangladesh

Duck plague (DP) is the most feared duck disease in the world. For isolation, identification, molecular detection and characterization of DP virus (DPV), a total of 94 samples were collected from commercial farms (n=6) and households (n=13) from Rajshahi (n=37), Netrokona (n=35) and Mymensingh (n=22) districts of Bangladesh. The samples were processed and inoculated into 11-13 days old embryonated duck eggs for virus propagation. Virus was identified using agar gel immunodiffusion test (AGIT) and passive hemagglutination (PHA) test, and was confirmed by polymerase chain reaction (PCR) targeting DNA polymerase and gC genes, followed by sequencing. Pathogenicity tests were performed using duck embryos, ducklings and ducks. Among the 94 samples, 17 isolates were confirmed as DPV by PCR amplification of partial DNA polymerase (446-bp) and gC genes (78-bp), respectively. One of the isolates (Anatid herpes 1 BAU DMH) was sequenced and found to be closely related with a Chinese variant of DPV (GenBank: JQ647509.1). Thus, we assume that both Bangladeshi and Chinese isolates of DPV may have a common ancestor. http://dx.doi. org/10.5455/javar.2015. b90
Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability

Protection of euchromatin from invasion by gene-repressive heterochromatin is critical for cellular health and viability. In addition to constitutive loci such as pericentromeres and subtelomeres, heterochromatin can be found interspersed in gene-rich euchromatin, where it regulates gene expression pertinent to cell fate. While hetero- and euchromatin are globally poised for mutual antagonism, the mechanisms underlying precise spatial encoding of heterochromatin containment within euchromatic sites remain opaque. We investigated ectopic heterochromatin invasion by manipulating the fission yeast mating type locus boundary, using a single-cell spreading reporter system. We found that heterochromatin repulsion is locally encoded by Set1/COMPASS on certain actively transcribed genes and that this protective role is most prominent at heterochromatin islands, small domains interspersed in euchromatin that regulate cell fate specifiers. Interestingly, this effect can be gene orientation dependent. Sensitivity to invasion by heterochromatin, surprisingly, is not dependent on Set1 altering overall gene expression levels. At least two independent pathways direct this Set1 activity–inhibition of catalysis by Suv39/Clr4 and disruption of nucleosome stability. Taken together, these results describe a mechanism for spatial encoding of euchromatic signals that repel heterochromatin invasion.
Clinical Implications of DES

Once prescribed to pregnant women to prevent risk of spontaneous abortion, diethylstilbestrol (DES) is now associated with an increased risk of breast cancer, clear cell adenocarcinoma (CCA) of the vagina and cervix, and reproductive anomalies. This article will summarize the potential long-term health implications of DES, the role of nurse practitioners in identifying exposed individuals, and proper clinical management.
Corrigendum Polymorphism in the melatonin receptor gene in buffalo populations of the Brazilian Amazon - Genet. Mol. Res. 15 (2): gmr.15027960.

The correction is only in the name of the first author and should be: E.M. Barbosa(1), B.B. Souza(2), R.C. Guimarães(2), J.S. N. Azevedo(3), E.C. Gonçalves(4), H.F. L. Ribeiro(2), S.T. Rolim Filho(2), E. Silva Filho(2).
Espacio Europeo de Educación Superior: estándares e indicadores de buenas prácticas para la atención a estudiantes universitarios con discapacidad

Acceso a la publicacion en formato electronico a traves del Servicio de Informacion sobre Discapacidad, SID.http://sid.usal. es/libros/discapacidad/26032/8-1/espacio-europeo-de-educacion-superior.aspx Los contenidos de esta publicacion son propiedad intelectual de sus respectivos autores.El INICO no se hace responsable de las ideas manifestadas por los mismos en esta publicacion.La realizacion de parte de este trabajo ha sido posible gracias la financiacion recibida del Real Patronato sobre Discapacidad y de la Junta de Castilla y Leon – Consejeria de Educacion (Proyecto US06/06)Coleccion Investigacion 6/2011(Distribucion Gratuita) 1a Edicion:2011-06-28 Autores:Emiliano Diez, Alba Alonso, Miguel Angel Verdugo, Maribel Campo, Isabel Sancho, Sergio Sanchez, Isabel Calvo y Eva Moral Ilustracion de cubierta:“Informacion” de Miguel Ortiz Ramos (III Concurso de fotografia digital del INICO-Fundacion Grupo Norte – “Las personas con discapacidad en la vida cotidiana”) Edita y distribuye:Instituto Universitariode Integracion en la ComunidadUniversidad de SalamancaAvenida de la Merced, 109-13137005 SalamancaTelef. 923 294 695 Fax 923 294 685correo-e: inico@usal.eshttp://inico.usal. esImprime:Imprenta KADMOSSalamancaISBN: 978-84-694-6473-1Deposito Legal: S. 1.242-2011Imprime KADMOSSalamanca, 2011
The Guilt of Nations: Restitution and Negotiating Historical Injustices. By Elazar Barkan. Baltimore: Johns Hopkins University Press, 2001. 456p. $18.95.

It seems timely and appropriate that the twentieth century—the century of the Holocaust, the Gulag Archipelago, the Killing Fields, the Cultural Revolution, and the “ethnic cleansing” in the Balkans and Rwanda—ended with a wave of growing interest in healing past injustices. Human rights organizations and international commissions investigate violations of human rights. International tribunals judge political leaders, warlords, and their soldiers. Historians, political scientists, and legal theorists study the implications of such crimes and punishments.
Carbon cycle feedbacks during the Oligocene-Miocene transient glaciation

Ice sheet models suggest that once formed, the large, high- altitude East Antarctic Ice Sheet was relatively self-stabilizing, due to its cold upper surface. The ice sheet hysteresis problem results from an inability to reconcile this expectation with geological evidence for episodes of ice sheet retreat. A classic example of this problem is manifested in benthic foraminiferal oxygen isotope records across the Oligocene-Miocene boundary (ca. 23 Ma), which display a transient ~1‰ excursion to higher values. The inferred increase and subsequent decrease in ice volume has been linked to advance and retreat of the Antarctic ice sheet across the continental shelf. However, oxygen isotope records alone do not provide unambiguous records of temperature and ice volume, hindering assessment of the driving mechanism for these variations. Here we present new benthic foraminiferal Mg/Ca, Li/Ca, and U/Ca records across the Oligocene- Miocene boundary from Ocean Drilling Program Sites 926 and 929. Our records demonstrate that Atlantic bottom-water temperatures varied cyclically, with the main cooling and warming steps followed by ice growth and decay respectively. We suggest that enhanced organic carbon burial acted as a positive feedback as climate cooled. Several lines of evidence suggest that the deglaciation was associated with an input of carbon to the ocean-atmosphere system, culminating in a previously unidentified seafloor dissolution event. We suggest that one of the initial sources of carbon was organic matter oxidation in ocean sediments. This study demonstrates that carbon cycle feedbacks should be considered when evaluating the stability of ancient ice sheets.
Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB

The proteasome inhibitor bortezomib is a new targeted treatment option for refractory or relapsed acute lymphoblastic leukemia (ALL) patients. However, a limited efficacy of bortezomib alone has been reported. A terminal pro-apoptotic endoplasmic reticulum (ER) stress/unfolded protein response (UPR) is one of the several mechanisms of bortezomib-induced apoptosis. Recently, it has been documented that UPR disruption could be considered a selective anti-leukemia therapy. CX-4945, a potent casein kinase (CK) 2 inhibitor, has been found to induce apoptotic cell death in T-ALL preclinical models, via perturbation of ER/UPR pathway. In this study, we analyzed in T- and B-ALL preclinical settings, the molecular mechanisms of synergistic apoptotic effects observed after bortezomib/CX-4945 combined treatment. We demonstrated that, adding CX-4945 after bortezomib treatment, prevented leukemic cells from engaging a functional UPR in order to buffer the bortezomib-mediated proteotoxic stress in ER lumen. We documented that the combined treatment decreased pro-survival ER chaperon BIP/Grp78 expression, via reduction of chaperoning activity of Hsp90. Bortezomib/CX-4945 treatment inhibited NF-κB signaling in T-ALL cell lines and primary cells from T-ALL patients, but, intriguingly, in B-ALL cells the drug combination activated NF-κB p65 pro-apoptotic functions. In fact in B-cells, the combined treatment induced p65-HDAC1 association with consequent repression of the anti-apoptotic target genes, Bcl-xL and XIAP. Exposure to NEMO (IKKγ)-binding domain inhibitor peptide reduced the cytotoxic effects of bortezomib/CX-4945 treatment. Overall, our findings demonstrated that CK2 inhibition could be useful in combination with bortezomib as a novel therapeutic strategy in both T- and B-ALL.
Predicting sensitivity of non-small-cell lung cancer to gefitinib: is there a role for P-Akt?

The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor of the ErbB family that is abnormally activated in epithelial tumors (1). Receptor activation leads to recruitment and phosphorylation of downstream intracellular substrates. Multiple pathways are activated, including the phosphatidylinositol 3–kinase/Akt (PI3K/Akt) cascade implicated in cell survival and the RAS/RAF/mitogen-activated protein kinase (MAPK) cascade associated with cell proliferation (2,3). Aberrant signaling through EGFR can lead to tumor-promoting cellular activities. EGFR is the target for cancer therapies such as gefitinib (4-quinazolinamine, N-[3-chloro-4-fluorophenylamino]-7methoxy6-[3-(4-morpholinyl) propoxy]) (4,5), which inhibits the tyrosine kinase activity of EGFR by reversibly competing with adenosine triphosphate (ATP) at the ATP-binding site within the EGFR protein. Gefitinib selectively inhibits EGFR when tested against several other kinases in vitro (6). In phase I trials, gefitinib induced responses in 10 of 100 unselected patients with non–small-cell lung cancer (NSCLC). Subsequently, in two phase II trials, radiographic regression of NSCLC was observed in 28% of patients enrolled in a study from Japan (7) and in 10% of patients enrolled in a study from Europe and the United States (8). On the basis of these two studies, regulatory authorities approved gefitinib for the treatment of patients with NSCLC after other chemotherapies had failed.