Miracle-dz/UniFAR-FTUs huggingface dataset:
Objects Don’t Object

Integrating system-justification and objectification theories, the research reported here broadens the scope of prior work on women’s self-objectification to examine its system-justifying function. I investigated the relation of trait and state self-objectification to support for the gender status quo and engagement in gender-based social activism among U.S. college women. Study 1 established that greater trait self-objectification was related to more gender-specific system justification and less engagement in gender-based social activism. The data supported a mediational model in which gender-specific system justification mediated the link between trait self-objectification and social activism. Results from Study 2, in which self-objectification was situationally activated, confirmed the same mediational model. These findings suggest that trait and state self-objectification may be part of a wider pattern of system-justifying behavior that maintains gender inequality and thwarts women’s pursuit of social justice.
In Vivo Imaging of Peripheral Benzodiazepine Receptors in Mouse Lungs: A Biomarker of Inflammation

The ability to visualize the immune response with radioligands targeted to immune cells will enhance our understanding of cellular responses in inflammatory diseases. Peripheral benzodiazepine receptors (PBR) are present in monocytes and neutrophils as well as in lung tissue. We used lipopolysaccharide (LPS) as a model of inflammation to assess whether the PBR could be used as a noninvasive marker of inflammation in the lungs. Planar imaging of mice administrated 10 or 30 mg/kg LPS showed increased [123I]-(R)-PK11195 radioactivity in the thorax 2 days after LPS treatment relative to control. Following imaging, lungs from control and LPS-treated mice were harvested for ex vivo gamma counting and showed significantly increased radioactivity above control levels. The specificity of the PBR response was determined using a blocking dose of nonradioactive PK11195 given 30 min prior to radiotracer injection. Static planar images of the thorax of nonradioactive PK11195 pretreated animals showed a significantly lower level of radiotracer accumulation in control and in LPS-treated animals (p < .05). These data show that LPS induces specific increases in PBR ligand binding in the lungs. We also used in vivo small-animal PET studies to demonstrate increased [11C]-(R)-PK11195 accumulation in the lungs of LPS-treated mice. This study suggests that measuring PBR expression using in vivo imaging techniques may be a useful biomarker to image lung inflammation.
Inverse association of serum bilirubin with metabolic syndrome and insulin resistance in Polish population.

BACKGROUND Bilirubin has got a potential anti-oxidant, anti-inflammatory and cytoprotective effect. It has been shown that its concentration is inversely related to cardiometabolic diseases. Recent studies have revealed the association between serum bilirubin concentrations and metabolic syndrome (MS) among children and adolescents in U.S. and among Korean adults. The aim of this study was to evaluate the association of total serum bilirubin level with MS and insulin resistance in Poland. METHODS We examined 1568 patients aged 18 to 93 years. The tested population was a nationally representative sample of Polish adults. They were derived from cross-sectional study, when serum total bilirubin level and risk factors of cardiovascular diseases were determined. RESULTS The prevalence of MS in bilirubin level quartiles (95% CI in parentheses) was 28.9% (24.5%-33.3%), 32.6% (28.3%-36.9%), 23.4% (19.0%-27.8%), 21.8% (17.5%-26.2%) respectively for quartiles 1-4 (p = 0.002) The multivariate analysis showed odds ratio for MS in third and fourth quartile of bilirubin level equal to 0.70 (0.50-0.99) and 0.68 (0.48-0.95) respectively in comparison to the lowest quartile. The more criteria of metabolic syndrome were fulfilled by the patient, the lower was mean total bilirubin level (p = 0.012). In study group there was also a strong, independent association of bilirubin level with fasting insulin level and insulin resistance (HOMA-IR). The odds ratio of insulin resistance was 0.53 (0.38-0.74) for the fourth quartile in reference to the lowest quartile of bilirubin. CONCLUSION In Polish adults serum total bilirubin level is inversely related to the prevalence of MS and insulin resistance.
Quality of life in children with Crohn's disease.

In a 10-week randomised cross-sectional study we used an 88-item questionnaire to assess the quality of life in 16 children (ages 8-17 years) with Crohn's disease and their families. The questionnaire covered six domains of health-related quality of life, including disease and its treatment, social, emotional, family, education, and future aspects. Crohn's disease affected education, with absenteeism in 12 and distraction during school work in six. Three children had had a home tutor, and five stated their need for one. Engaging in sports was a problem for eight children, mainly because of a lack of energy in five and the presence of a stoma in three children. Three children had missed every PE lesson in 1 year. Five children cited the social problem of being unable to stay over at friends' houses. Bullying concerned parents more than the children. Holiday difficulties included long distance traveling or lack of toilet facilities during school trips. Elemental diet was the preferred treatment, although the majority complained about the taste. Surgery was the most effective method of symptom control, though the resulting stoma was upsetting and restricted sports activities. Children on steroids had more depressive symptoms. Using the Rutter A Questionnaire, five children were designated "neurotic. " Parents' views of the severity of symptoms significantly correlated with their children's views regarding rectal bleeding, poor growth, lack of energy, and poor appetite (p < 0.01). The main parental concerns were the side effects of medications and issues concerning their children's future, including schooling, job prospects, and marriage. The parents of 11 children cited problems with children's behaviour. The parents of seven cited disruption of work, and those of six named taking holidays. Crohn's disease in children, in addition to being a symptomatically disabling condition, has a great impact on the health-related quality of life of both sufferers and their parents. The questionnaire was a useful instrument, and with some adjustment it can be used again in large group studies.
Do repeat victims of interpersonal violence have different demographic and socioeconomic characters from non-repeat victims of interpersonal violence and the general population? A population-based case-control study

Aim: To study if adult repeat victims of violence have different demographic and socioeconomic character from non-repeat victims of violence and the general population. Methods: Case—control study comparing demographic and socioeconomic characteristics before first-time victimisation among repeat victims of violence to that of non-repeat victims and population-based controls. Repeat and non-repeat victims were included from an urban emergency department and an institute for forensic medicine. Data was analysed using logistic regression in unadjusted, semi-adjusted, and fully-adjusted models. Results: For almost all demographic and socioeconomic factors in our study, the strongest associations were found when repeat victims were compared to population-based controls, whereas associations obtained from comparison with non-repeat victims were less pronounced. Compared to non-repeat victims, factors most strongly associated with repeat victimisation were being a pensioner (OR 3.21), being unemployed (OR 2.11), high level of lifetime unemployment (OR 1.50), high level of household crowding (OR 1.49), and living without a partner (OR 1.30). Compared to population-based controls, factors most strongly associated with victimisation were being a pensioner (OR 6.83), being unemployed (OR 3.01), living without a partner (OR 3.15), high level of lifetime unemployment (OR 2.40), high levels of household crowding (OR 2.35), large age difference to partner (OR 1.82), and citizenship in a country outside Europe (OR 1.61). Conclusions: The study indicates that repeat victims of violence may be a demographic and socioeconomic subgroup of adult victims of violence characterised by certain pronounced risk factors which are already present at the time of the first episode of violent victimisation.
Renal resistive index in patients with true resistant hypertension: results from the RESIST-POL study.

BACKGROUND Increased ultrasound Doppler renal resistive index (RRI) is a marker of atherosclerotic and hypertensive organ damage both at renal and systemic level. AIM To evaluate RRI in patients with true resistant hypertension (TRHT) in the RESIST-POL study. METHODS From 204 patients diagnosed with TRHT in the RESIST-POL study, 151 patients (90 male, 61 female, mean age: 47.7 ± 10.4, range: 19-65 years) without secondary hypertension were included into the analysis. All patients were characterised by estimated glomerular filtration rate > 60 mL/min/1.73 m2 and no history of diabetes prior to the study. As a control group we included 50 age- and gender-matched patients (35 male, 15 female, mean age: 46.8 ± 10.4, range: 19-65 years) with primary well-controlled hypertension. The groups also did not differ in respect to the number of years of known history of hypertension. The RRIs were evaluated on the basis of the Doppler ultrasound examination. Increased RRI was defined as ≥ 0.7. RESULTS Both groups did not differ in terms of renal function. Patients with TRHT were characterised by higher RRI as compared with the group with well-controlled hypertension (0.62 ± 0.05 vs. 0.60 ± 0.05, p < 0.05). In the TRHT group RRI correlated significantly with age, clinic and ambulatory blood pressure measurement, diastolic blood pressure (DBP) levels, as well as with clinic pulse pressure (PP) (r = 0.297; p = 0.001), with daytime (r = 0.355; p < 0.001) and nighttime (r = 0.313; p < 0.001) PP, and with fasting glucose concentration (r = 0.215; p = 0.008) and E/E’ ratio (r = 0.289; p = 0.001) on echocardiography. RRI values were significantly higher in TRHT patients with newly diagnosed diabetes as compared with TRHT patients without diabetes (0.65 ± 0.05 vs. 0.62 ± 0.05, p = 0.022). Age, daytime DBP, daytime PP, and E/E’ ratio but not fasting glucose concentration correlated independently with RRI in the model. Among patients with TRHT, patients with increased RRI were characterised by older age (52.2 ± 4.9 vs. 47.3 ± 10.6 years, p = 0.012), higher body mass index (32.8 ± 6.0 vs. 29.7 ± 4.5 kg/m2, p = 0.034), as well as lower daytime and nighttime DBP values and lower daytime and nighttime heart rate, as compared to patients with RRI < 0.7. The TRHT patients with increased RRI as compared to patients with RRI < 0.7 were characterised also by higher daytime and nighttime PP. Both groups did not differ in respect of renal function. CONCLUSIONS Our study showed that the patients with TRHT were characterised by significantly higher RRI values as compared to the subjects with well-controlled hypertension. It may also be suggested that in the subjects with TRHT renal vascular resistance is related to blood pressure values, selected echocardiographic abnormalities, and some surrogate markers for metabolic and cardiovascular events, including fasting glucose plasma concentration and PP, respectively.
Long‐Term Debt and Optimal Policy in the Fiscal Theory of the Price Level

The fiscal theory says that the price level is determined by the ratio of nominal debt to the present value of real primary surpluses. The maturity structure of the debt matters in this theory. For example, it determines whether news of future deficits implies current inflation or future inflation, and the long-term debt allows the government to offset surplus shocks by ex-post devaluation. In the optimal policy, the government uses fiscal operations to smooth cyclical fiscal shocks. Since policy movements react to events rather than cause them, the optimal policy produces time series that are similar to U.S. time series.
Novel role of ASC as a regulator of metastatic phenotype

Disorders of cytoskeletal remodeling and signal transduction are frequently involved in cancer progression. In particular, apoptosis‐associated speck‐like protein containing a caspase‐recruitment domain (ASC) has been reported a proapoptotic molecule that is epigenetically silenced in several human cancers. ASC is a well‐characterized adaptor protein involved in the formation of multiprotein oligomers, called inflammasomes, and plays a crucial role in the activation and secretion of interleukin‐1β and interleukin‐18 in innate immune cells. However, the function of ASC in the regulation of tumor progression remains elusive. The present investigation examined the involvement of ASC in cancer progression and the acquisition of metastatic ability. To determine the effect of ASC depletion in in vitro and in vivo model systems, ASC was stably knocked down in B16 murine melanoma cell lines using retroviral transduction of shRNA. ASC suppression increased the motility of B16BL6 cells in scratch assays and augmented invasiveness as assessed by a Matrigel‐coated transwell system. Invadopodia formation and Src phosphorylation level were markedly enhanced in ASC‐knockdown cells as well. Since caspase‐8 has been reported to enhance cellular migration by Tyr380 phosphorylation via Src, we examined Tyr380 phosphorylation of caspase‐8 in ASC‐knockdown cells and found it to be elevated in ASC‐knockdown cells but attenuated by z‐VAD‐fmk or z‐IETD‐fmk. Moreover, ASC ablation increased pulmonary metastasis in mice after intravenous injection of B16BL6 cells. Our cumulative findings indicate that ASC suppresses cancer metastasis and progression via the modulation of cytoskeletal remodeling and the Src‐caspase‐8 signaling pathway.
Gray matter involvement predicts chemosensitivity and prognosis in gliomatosis cerebri

Background: In gliomatosis cerebri (GC), defined as a diffuse neoplastic glial cell infiltration of the brain, upfront chemotherapy is often proposed as an alternative to radiotherapy. GC invades both white matter and gray matter in varying proportions, as reflected by the gray matter index (GMI), i.e., the estimated percentage of gray matter involvement. Methods: The GMI was estimated in 71 patients with GC (42 men and 29 women; median age, 47 years) treated with upfront chemotherapy (7 PCV, 64 temozolomide). Results: Median GMI was 30%. Patients were separated into 2 groups according to this median GMI. Compared to the 33 patients with GMI >30% (group B), the 38 patients from group A (defined as GMI ≤30%) had better performance status (p = 0.03), higher response rate to chemotherapy (30/38 vs only 5/33; p < 0.0001), longer progression-free survival (21.2 vs 11.7 months, p = 0.005), and longer overall survival (56.1 vs 26.4 months; p = 0.003). There was no significant correlation with histologic subtype (oligodendroglial vs astrocytic or mixed GC), grading, tumor localization (particularly basal nuclei involvement), or laterality. The deletion of chromosomes 1p and 19q tended to be more frequent in group A (8/17 [47%] vs 1/9 [11%] in group B [p = 0.057]). Conclusion: These data suggest that gray matter index is a prognostic and predictive marker in gliomatosis cerebri that may in part depend on the 1p/19q status.
Electricity consumption and economic growth: Evidence from Cameroon

ABSTRACT This paper analyzes the electricity sector and examines the causal relationship between electricity consumption and economic growth in Cameroon for the period 1971–2013. Stationary tests, the Johansen co-integration test, the vector autoregressive (VAR) model, and the Granger causality test were used as an econometric approach. The results show that: all variables are I(1); there is no co-integration relation between the variables; and there is no causal relationship between electricity consumption and economic growth. Moreover, the results of the Granger causality test confirm the neutrality hypothesis. Despite its enormous hydroelectric potential, Cameroon does not yet meet its energy requirements in the electricity sector. It must, therefore, implement a strong policy of upgrading, producing, distributing, and popularizing electricity, in order to satisfy demand and contribute to economic growth.
Turnover of env Variable Region 1 and 2 Genotypes in Subjects with Late-Stage Human Immunodeficiency Virus Type 1 Infection

ABSTRACT The env gene of human immunodeficiency virus type 1 (HIV-1) includes some of the most genetically diverse regions of the viral genome, which are called variable regions 1 through 5 (V1 through V5). We have developed a heteroduplex tracking assay to detect changes in variable regions 1 and 2 of env (V1/V2-HTA). Using sequences from two molecular clones as probes, we have studied the nature of longitudinal virus population changes in a cohort of HIV-1-infected subjects. Viral sequences present in 21 subjects with late-stage HIV-1 infection were initially screened for stability of the virus population by V1/V2-HTA. The virus populations at entry comprised an average of five coexisting V1/V2 genotypic variants (as identified by HTA). Eight of the 21 subjects were examined in detail because of the dynamic behavior of their env variants over an approximately 9-month period. In each of these cases we detected a single discrete transition of V1/V2 genotypes based on monthly sampling. The major V1/V2 genotypes (those present at >10% abundance) from the eight subjects were cloned and sequenced to define the nature of V1/V2 variability associated with a discrete transition. Based on a comparison of V1/V2 genotypic variants present at entry with the newly emerged variants we categorized the newly emerged variants into two groups: variants without length differences and variants with length differences. Variants without length differences had fewer nucleotide substitutions, with the changes biased to either V1 or V2, suggestive of recent evolutionary events. Variants with length differences included ones with larger numbers of changes that were distributed, suggestive of recall of older genotypes. Most length differences were located in domains where the codon motif AVT (V = A, G, C) had become enriched and fixed. Finally, recombination events were detected in two subjects, one of which resulted in the reassortment of V1 and V2 regions. We suggest that turnover in V1/V2 populations was largely driven by selection on either V1 or V2 and that escape was accomplished either through changes focused in the region under selection or by the appearance of a highly divergent variant.
Delayed presentation of symptomatic breast cancers in Hong Kong: experience in a public cancer centre.

OBJECTIVE Delayed presentation is an important obstacle to improving cancer treatment outcomes. We aimed to study the magnitude of this problem in Hong Kong and the factors associated with delayed presentation of patients with symptomatic breast cancers. DESIGN Retrospective study using self-administered questionnaires. SETTING Clinical Oncology Department in a regional public hospital in Hong Kong. PATIENTS A total of 158 Chinese women with breast cancer referred to our hospital between October 2006 and December 2007 consented to participate in this study. Among these, 59 (37%) patients were referred after having surgery in private sector. RESULTS The mean total delay (from first symptom to treatment) was 22 weeks. The mean patient delay (from first symptom to first consultation) was 13 weeks, constituting the largest component (60%) of the total delay. After symptom onset, the delay exceeded 12 weeks for consulting a doctor in 29%, and for receipt of treatment in 52% of them. Low family income (<HK$5000 per month; P<0.001) and surgery in public hospitals (P=0.013) were both independent predictors of patient delay. Surgery in public hospitals (P=0.006) and low family income (P=0.005) were the only predictors of doctor/system delay and total delay, respectively. CONCLUSIONS Delayed presentation and treatment of symptomatic breast cancer remains an important issue in Hong Kong. Apart from socio-economic factors, limited access to public medical care was likely an important contributing factor in delays related to patients as well as to doctor/system.
Returns to investment in education: a decennial review of the global literature

ABSTRACT In the 60-plus year history of returns to investment in education estimates, there have been several compilations in the literature. This paper updates Psacharopoulos and Patrinos and reviews the latest trends and patterns based on 1120 estimates in 139 countries from 1950 to 2014. The private average global return to a year of schooling is 9% a year. Private returns to higher education increased, raising issues of financing and equity. Social returns to schooling remain high. Women continue to experience higher average returns to schooling, showing that girls’ education remains a priority.
Early-life lead exposure results in dose- and sex-specific effects on weight and epigenetic gene regulation in weanling mice.

AIMS Epidemiological and animal data suggest that the development of adult chronic conditions is influenced by early-life exposure-induced changes to the epigenome. This study investigates the effects of perinatal lead (Pb) exposure on DNA methylation and bodyweight in weanling mice. MATERIALS & METHODS Viable yellow agouti (A(vy)) mouse dams were exposed to 0, 2.1, 16 and 32 ppm Pb acetate before conception through weaning. Epigenetic effects were evaluated by scoring coat color of A(vy)/a offspring and quantitative bisulfite sequencing of two retrotransposon-driven (A(vy) and CDK5 activator-binding protein intracisternal A particle element) and two imprinted (Igf2 and Igf2r) loci in tail DNA. RESULTS Maternal blood Pb levels were below the limit of detection in controls, and 4.1, 25.1 and 32.1 µg/dl for each dose, respectively. Pb exposure was associated with a trend of increased wean bodyweight in males (p = 0.03) and altered coat color in A(vy)/a offspring. DNA methylation at A(vy) and the CDK5 activator-binding protein intracisternal A-particle element was significantly different from controls following a cubic trend (p = 0.04; p = 0.01), with male-specific effects at the A(vy) locus. Imprinted genes did not shift in methylation across exposures. CONCLUSION Dose- and sex-specific responses in bodyweight and DNA methylation indicate that Pb acts on the epigenome in a locus-specific fashion, dependent on the genomic feature hosting the CpG site of interest, and that sex is a factor in epigenetic response.
Analisis Pengaruh Pendidikan dan PDRB per Kapita terhadap Jumlah Penduduk Miskin di Provinsi Aceh

Tujuan penelitian ini adalah menganalisis pengaruh pendidikan dan PDRB per kapita baik secara parsial maupun simultan terhadap jumlah penduduk miskin di Provinsi Aceh. Data sekunder berupa data pendidikan (rata- rata lama sekolah), PDRB Per Kapita dan Jumlah Penduduk Miskin di Provinsi Aceh tahun 2007-2017. Metode analisis menggunakan analisis regresi linear berganda. Dari hasil pengujian diperoleh bahwa secara parsial, rata-rata lama sekolah berpengaruh negatif tetapi tidak signifikan terhadap jumlah penduduk miskin di Provinsi Aceh; sementara PDRB per kapita berpengaruh negatif dan signifikan terhadapjumlah penduduk miskin di Provinsi Aceh. Secara simultan, rata-rata lama sekolah dan PDRB perkapita berpengaruh signifikan terhadap jumlah penduduk miskin di Provinsi Aceh. Koefisien determinasi menunjukkan bahwa rata-rata lama sekolah dan PDRB per kapita berkontribusi sebesar 84,1 persen terhadap jumlah penduduk miskin; sedangkan selebihnya dipengaruhi oleh variabel-variabel lain yang tidak diteliti dalam model penelitian ini, seperti pengangguran atau produktivitas tenaga kerja.