Miracle-dz/UniFAR-FTUs huggingface dataset:
Serious Impact of Handlebar Injuries

Background. Injuries from bicycles is a leading cause of trauma in children. We sought to investigate the epidemiology of bicycle handlebar injuries. Methods. A retrospective analysis of bicycle trauma treated at our institution was preformed. Results. A total of 462 children younger than 17 years had bicycle trauma. Abdominal handlebar injuries, representing 9% of bicycle injuries, contributed to 19% of all internal organ injuries, and 45.4% of solid, 87.5% of hollow, 66.6% of vascular or lymphatic, and 100% of pancreatic injuries. Handlebar injuries were 10 times more likely to cause severe injury, yet more than half of the children were misdiagnosed at their initial presentation. Delayed diagnosis and longer hospital stays were observed in handlebar injuries to the abdomen. Conclusion. Physicians should be aware of the serious impact of bicycle handlebar injury to the abdomen. The mechanism alone should raise the suspicion of internal organ injury, and timely imaging and surgical consultation.
Does big data mean big knowledge? KM perspectives on big data and analytics

Purpose This viewpoint study aims to make the case that the field of knowledge management (KM) must respond to the significant changes that big data/analytics is bringing to operationalizing the production of organizational data and information. Design/methodology/approach This study expresses the opinions of the guest editors of “Does Big Data Mean Big Knowledge? Knowledge Management Perspectives on Big Data and Analytics”. Findings A Big Data/Analytics-Knowledge Management (BDA-KM) model is proposed that illustrates the centrality of knowledge as the guiding principle in the use of big data/analytics in organizations. Research limitations/implications This is an opinion piece, and the proposed model still needs to be empirically verified. Practical implications It is suggested that academics and practitioners in KM must be capable of controlling the application of big data/analytics, and calls for further research investigating how KM can conceptually and operationally use and integrate big data/analytics to foster organizational knowledge for better decision-making and organizational value creation. Originality/value The BDA-KM model is one of the early models placing knowledge as the primary consideration in the successful organizational use of big data/analytics.
How MNC's subsidiaries may improve their innovative performance? The role of external sources and knowledge management capabilities

Purpose This paper aims at exploring the effect of knowledge management (KM) practices on the relationship between external research and development (R&D) and innovative performance. The authors argue that the firms which develop and possess superior KM capabilities have the ability to better manage external knowledge and combine it with the internal one. Design/methodology/approach The authors used a sample of 117 European MNC subsidiaries. An OLS regression analysis was carried out to evaluate the moderator effect of KM on the relationship between external R&D and innovative performance. Findings The authors found positive evidences in favor of a moderator effect of KM. This means that subsidiaries with superior KM capabilities are more effective in using external R&D, augmenting the magnitude of their external sources of knowledge and, consequently, improving their innovative performance. Practical implications Managerially speaking, both corporate and subsidiaries’ managers need to understand the relevance of managing knowledge effectively and efficiently at the subsidiary level. Corporate managers need to allocate more resources (both financial and managerial) to the subsidiaries that are active in knowledge transfer and sharing, while subsidiaries managers need to implement practically the KM tools and processes at the subsidiary organizational level to improve subsidiary’s innovative performance. Originality/value This paper contributes mainly to the KM field, highlighting the importance of KM at the subsidiary level, whereas most of previous studies focus on different units of analysis.
Evaluation of disorder predictions in CASP9

Lack of stable three‐dimensional structure, or intrinsic disorder, is a common phenomenon in proteins. Naturally, unstructured regions are proven to be essential for carrying function by many proteins, and therefore identification of such regions is an important issue. CASP has been assessing the state of the art in predicting disorder regions from amino acid sequence since 2002. Here, we present the results of the evaluation of the disorder predictions submitted to CASP9. The assessment is based on the evaluation measures and procedures used in previous CASPs. The balanced accuracy and the Matthews correlation coefficient were chosen as basic measures for evaluating the correctness of binary classifications. The area under the receiver operating characteristic curve was the measure of choice for evaluating probability‐based predictions of disorder. The CASP9 methods are shown to perform slightly better than the CASP7 methods but not better than the methods in CASP8. It was also shown that capability of most CASP9 methods to predict disorder decreases with increasing minimum disorder segment length. Proteins 2011;. © 2011 Wiley‐Liss, Inc.
Implementing the Key Components of Specialized Drug Treatment Courts: Practice and Policy Considerations

The perceived need for specialized drug courts emerged from the most recent “war on drugs. ” Courts were no longer able to handle such cases effectively because of an overwhelming volume of drug arrests and prosecutions. The increased emphasis on drug enforcement also revealed that many of the most serious criminally involved drug-using offenders were undeterred by threats of incarceration, but were amenable to substance abuse treatment. Drug court professionals have identified several “key components” that must be in place for these courts to achieve their goals of reducing drug use and crime. Through the lens of these key drug court components, we examine the development and initiation of specialized drug treatment courts in Cook County (Chicago), Illinois. By exploring and documenting Cook County’s experiences, we elucidate several of the basic policy and organizational issues surrounding the implementation and operations of specialized drug treatment courts in the United States.
Residencies With Dual Internal Medicine and Pediatrics Programs Outperform Others on the American Board of Pediatrics Certifying Examination

Objective. The purpose was to evaluate American Board of Pediatrics Certifying Examination performance based on if a residency offers a dual internal medicine–pediatrics program, hypothesizing that having a dual-accreditation program is associated with higher exam performance. Methods. Pediatric residency programs in the United States were retrospectively evaluated from 2010 to 2012. The accreditation status was determined. Mann–Whitney U tests were performed for continuous variables, and χ2 tests were performed for categorical variables, using an α = . 05. Results. For 190 residencies, 75 (39%) had dual Med-Peds accreditation whereas 115 (61%) did not. The median overall residency pass rate for Med-Peds accredited programs (83%; interquartile range = 74% to 91%) was higher than other programs (78%; interquartile range = 65% to 89%; P = .02). The pass rate for examinees from Med-Peds accredited programs (n = 4,108; 84.2%) was higher than examinees from other programs (n = 4,310; 79.6%; P < .001). Conclusions. The presence of a dual-accreditation residency program should be a consideration of future applicants.
The Impact of a Locally Applied Vibrating Device on Outpatient Venipuncture in Children

Objective. To assess the impact of a locally applied vibrating device on outpatient venipuncture in children. Method. A retrospective review of survey data collected prospectively as part of a quality improvement project. Both patients and phlebotomists were surveyed. The sample consisted of 64 children aged 4 to 18 years (29 prior to the implementation of the vibrating device and 35 afterward) and 7 phlebotomists. Results. Prior to the use of the vibrating device, 17 children (59%) indicated that they wished something had been done to decrease venipuncture pain. Eighty percent of the cohort that used the vibrating device indicated that they would like it used for future procedures. Children with previous venipuncture experiences appeared to benefit most from use of the vibrating technique. The phlebotomists reported that vibration made the procedure easier in 81% of the cases; none reported that it complicated the procedure. Conclusions. Locally applied vibration appears to be a well-accepted technique to minimize pediatric venipuncture discomfort that may facilitate completion of the procedure.
A double‐blind, placebo‐controlled comparison of treatment with fluticasone propionate and levocabastine in patients with seasonal allergic rhinitis

Fluticasone propionate aqueous nasal spray (FPANS) is a topically active glucocorticoid which has been successfully used for the treatment of seasonal allergic rhinitis (SAR). Topical levocabastine is a highly selective H1 antagonist which has been proposed as an alternative treatment of SAR. The purpose of this study was to compare the clinical efficacy of two topical nasal treatments, FPANS and levocabastine, in the treatment of SAR. Additionally, the effect of treatments on nasal inflammation was examined during natural pollen exposure. A group of 288 adolescent and adult patients with at least a 2‐year history of SAR to seasonal pollens participated in a multicenter, double‐blind, double‐dummy, and placebo‐controlled study. Patients were treated with either FPANS 200 μg, once daily (n=97), or topical levocabastine, 200 μg, given twice daily (n=96), or matched placebo (n=95) for a period of 6 weeks, starting from the expected beginning of the pollen season. Clinically relevant pollens included Parietaria, olive, and grass. Assessment of efficacy was based on scores of daily nasal symptoms and on nasal cytology of nasal lavage. Nasal lavage was performed immediately before, during, and at the end of treatment in 39 patients. FPANS significantly increased the percentage of symptom‐free days for nasal obstruction on waking and during the day, rhinorrhea, sneezing, and itching. FPANS provided a better control for night and day nasal obstruction (P<0.02 and P<0.01) and rhinorrhea (P<0.01) than levocabastine. In addition, fewer patients treated with FPANS used rescue medication (P<0.025). The percentage of eosinophils in nasal lavage was reduced only during treatment with FPANS. The results of this study indicate that FPANS 200 μg, once daily, provides a better clinical effect than levocabastine 200 μg, twice daily, in patients with SAR. Unlike levocabastine, FPANS significantly attenuates nasal eosinophilia during pollen exposure, a feature which may explain its therapeutic efficacy.
Understanding knowledge creation in the context of knowledge-intensive business processes

Purpose This paper aims to investigate knowledge creation in the context of knowledge-intensive business processes (KIBPs) and seeks to identify the challenges and opportunities associated with this phenomenon. Design/methodology/approach This study used a grounded theory approach to develop a framework based on 30 interviews across three different types of organizations. Findings The findings argue knowledge creation in the context of KIBP is negatively influenced by the lack of support for process-competency requirements within knowledge-intensive (KI) processes. These process-competency requirements center on the ability to effectively engage with the process, develop reasoning skills to handle KIBP and gain a higher-level perspective of the KIBP within the organization. Practical implications For practitioners, the opportunity exists to explore their organizational influences on the process-competencies to reduce the negative impact of any gaps identified within their KIBPs. Originality/value Although previous studies explore knowledge creation in a broad sense, this paper examines the phenomenon specifically within the context of KIBPs and analyze the potential for organizations to enhance their knowledge creation initiatives in this context.
Skills and training needs for use of electronic information resources (EIRs) among students in four Tanzanian Universities

This article is based on a broader study that investigated the status and practice of Information Literacy (IL) for teaching and learning in four Tanzanian universities; namely Sokoine University of Agriculture (SUA), University of Dar-Es-Salaam (UDSM), Iringa University College (IUCO) and Saint Augustine University of Tanzania (SAUT). The primary intention of the study was to establish the best ways of introducing and improving IL programmes in these institutions. The article reports on the findings regarding students’ knowledge, skill and training needs in using Electronic Information Resources (EIRs). Data was collected using a questionnaire-based survey administered to 1123 undergraduate students. Probability sampling was used to sample students across the four universities, faculties and years of study. The response rate was 59.1%. The study findings revealed that although students in Tanzanian universities have access to and use various EIRs both for academic and non-academic work they still lack adequate knowledge and skills in some aspects, including searching and evaluation. The article therefore recommends the development of ICT infrastructures, that librarians and teaching staff become role models and mentors to students in using EIRs, and that teaching staff adopt an active learning and student-centred approach in their teaching as well as strengthening IL programmes as intervention measures for improving students’ skills in using EIRs.
Acute Pediatric Musculoskeletal Pain Management in North America

Children’s musculoskeletal (MSK) injury pain remains poorly managed. This survey of pediatric emergency physicians and orthopedic surgeons assessed analgesia administration practices and discharge advice for children with acute MSK pain; 683 responses were received. Ibuprofen was the most commonly reported analgesic used in the emergency department (52%) and at discharge (68%). Most (85%) reported using oral opioids in the previous 6 months. Codeine use was the most commonly reported opioid used in the emergency department (38%) and at home (51%). For equal levels of pain, younger children received less opioids than older children. Younger physicians and recent graduates chose acetaminophen and codeine more than older and more experienced colleagues, who preferred ibuprofen and non-codeine containing opioid compounds (P < .001 and .006, respectively). Orthopedic surgeons reported less ibuprofen use than pediatric emergency physicians (P < .001). Choice of analgesic agents is heterogeneous among physicians and is influenced by pain severity, child’s age, and physician characteristics.
Widowed mama-grannies buffering HIV/AIDS-affected households in a city slum of Kampala, Uganda

This article explores the experiences, challenges and coping strategies of urban elderly residents in Kasubi-Kawaala, a slum on the margins of Kampala city, Uganda. The city is mainly stereotyped as a space for able-bodied individuals able to hustle, innovatively compete for limited resources, and accrue themselves benefits. It is widely assumed that old age causes people to retire to rural areas. Thus, the ‘urban elderly’ present an anomaly. Yet, they play a very significant role in the city. Many support dependent grandchildren, many of whom have been orphaned by AIDS.
Impact of Co-management at the Primary-Subspecialty Care Interface on Follow-up and Referral Patterns for Patients With Concussion

Background: Co-management is a collaborative care model that consists of structured tools to define and document care delivered by 2 or more providers. We evaluated the impact of implementing co-management at the interface between pediatric primary care providers (PCPs) and subspecialists. Methods: Participating PCPs (n = 9) were trained on management of concussion using the co-management tools. Co-managed patients with concussion were prospectively enrolled (n = 148) and compared to a retrospective audit of non–co-managed patients (n = 50). Results: PCPs using co-management demonstrated adherence to the tools. PCPs were significantly more likely to provide follow-up care to patients when using the co-management tools. All participating PCPs reported that co-management enhanced their expertise in caring for patients with concussion. Conclusions: Co-management can enhance PCPs’ capacity to independently manage the care of patients with concussion. Co-management led to an observed change in practice that merits further exploration in terms of cost, quality, and clinical outcomes.
Solvated protein–protein docking using Kyte‐Doolittle‐based water preferences

HADDOCK is one of the few docking programs that can explicitly account for water molecules in the docking process. Its solvated docking protocol starts from hydrated molecules and a fraction of the resulting interfacial waters is subsequently removed in a biased Monte Carlo procedure based on water‐mediated contact probabilities. The latter were derived from an analysis of water contact frequencies from high‐resolution crystal structures. Here, we introduce a simple water‐mediated amino acid–amino acid contact probability scale derived from the Kyte‐Doolittle hydrophobicity scale and assess its performance on the largest high‐resolution dataset developed to date for solvated docking. Both scales yield high‐quality docking results. The novel and simple hydrophobicity scale, which should reflect better the physicochemical principles underlying contact propensities, leads to a performance improvement of around 10% in ranking, cluster quality and water recovery at the interface compared with the statistics‐based original solvated docking protocol. Proteins 2013. © 2012 Wiley Periodicals, Inc.
Management and governance: organizational culture in relation to enterprise life cycle

Purpose – The behaviour of an enterprise (including ethical behaviour) strongly depends on the organization’s culture, values and beliefs. The purpose of this paper is to demonstrate that organizational culture differs according to enterprise life cycle stage. Also the importance of the knowledge and awareness of these differences to enterprises’ management in order to be able to ensure enterprises’ success is argued. Design/methodology/approach – The case study research methodology was applied to explore the differences in the type of organizational culture as well as cultural strength depending on the enterprise’s life cycle stage. For the empirical testing, the author have selected Slovenia, one of the most developed European post-socialist transition countries. Findings – The research revealed differences in the types and strengths of enterprises’ organizational cultures and showed their dependence on the enterprises’ life cycle stages. Practical implications – Knowledge of differences in organization.
In vitro and in vivo characterization of designed immunogens derived from the CD‐helix of the stem of influenza hemagglutinin

The conserved “stem” domain of influenza virus hemagglutinin (HA) is a target for broadly neutralizing antibodies and a potential vaccine antigen for induction of hetero‐subtypic protection. The epitope of 12D1, a previously reported bnAb neutralizing several H3 subtype influenza strains, was putatively mapped to residues 76–106 of the CD‐helix, also referred to as long alpha helix (LAH) of the HA stem. A peptide derivative consisting of wt‐LAH residues 76–130 conjugated to keyhole limpet hemocyanin was previously shown to confer robust protection in mice against challenge with influenza strains of subtypes H3, H1, and H5 which motivated the present study. We report the design of multiple peptide derivatives of LAH with or without heterologous trimerization sequences and show that several of these are better folded than wt‐LAH. However, in contrast to the previous study immunization of mice with wt‐LAH resulted in negligible protection against a lethal homologous virus challenge, while some of the newly designed immunogens could confer weak protection. Combined with structural analysis of HA, our data suggest that in addition to LAH, other regions of HA are likely to significantly contribute to the epitope for 12D1 and will be required to elicit robust protection. In addition, a dynamic, flexible conformation of isolated LAH peptide may be required for eliciting a functional anti‐viral response. Proteins 2013; 81:1759–1775. © 2013 Wiley Periodicals, Inc.
Structural and thermodynamic folding characterization of triosephosphate isomerases from Trichomonas vaginalis reveals the role of destabilizing mutations following gene duplication

We report the structures and thermodynamic analysis of the unfolding of two triosephosphate isomerases (TvTIM1 and TvTIM2) from Trichomonas vaginalis. Both isoforms differ by the character of four amino acids: E/Q 18, I/V 24, I/V 45, and P/A 239. Despite the high sequence and structural similarities between both isoforms, they display substantial differences in their stabilities. TvTIM1 (E18, I24, I45, and P239) is more stable and less dissociable than TvTIM2 (Q18, V24, V45, and A239). We postulate that the identities of residues 24 and 45 are responsible for the differences in monomer stability and dimer dissociability, respectively. The structural difference between both amino acids is one methyl group. In TvTIMs, residue 24 is involved in packing α‐helix 1 against α‐helix 2 of each monomer and residue 45 is located at the center of the dimer interface forming a “ball and socket” interplay with a hydrophobic cavity. The mutation of valine at position 45 for an alanine in TvTIM2 produces a protein that migrates as a monomer by gel filtration. A comparison with known TIM structures indicates that this kind of interplay is a conserved feature that stabilizes dimeric TIM structures. In addition, TvTIMs are located in the cytoplasm and in the membrane. As TvTIM2 is an easily dissociable dimer, the dual localization of TvTIMs may be related to the acquisition of a moonlighting activity of monomeric TvTIM2. To our knowledge, this is the simplest example of how a single amino acid substitution can provide alternative function to a TIM barrel protein. Proteins 2014; 82:22–33. © 2013 Wiley Periodicals, Inc.
Opiate misuse in pregnancy: Findings of a retrospective case note series

This is a retrospective review of pregnant opiate users registered with a pregnant drug-users service between January 2001 and October 2002. The aim was to identify the obstetric and neonatal characteristics of these high-risk pregnancies, the level of contact with the service and the relationship between level of attendance and pregnancy outcome. There were no pregnancy losses during the studied period. The birth weights of 27 of 39 babies were ≤10th centile for gestational age. Associations between different antenatal variables and pregnancy outcomes were tested. The positive association between attending ≥70% of expected antenatal visits to the service and the birth weight centile reached statistical significance. This has implications for the development of models of service delivery for these high-risk pregnancies.