Miracle-dz/UniFAR-FTUs huggingface dataset:
Identity-Specific Reward Representations in Orbitofrontal Cortex Are Modulated by Selective Devaluation

Goal-directed behavior is sensitive to the current value of expected outcomes. This requires independent representations of specific rewards, which have been linked to orbitofrontal cortex (OFC) function. However, the mechanisms by which the human brain updates specific goals on the fly, and translates those updates into choices, have remained unknown. Here we implemented selective devaluation of appetizing food odors in combination with pattern-based neuroimaging and a decision-making task. We found that in a hungry state, participants chose to smell high-intensity versions of two value-matched food odor rewards. After eating a meal corresponding to one of the two odors, participants switched choices toward the low intensity of the sated odor but continued to choose the high intensity of the nonsated odor. This sensory-specific behavioral effect was mirrored by pattern-based changes in fMRI signal in lateral posterior OFC, where specific reward identity representations were altered after the meal for the sated food odor but retained for the nonsated counterpart. In addition, changes in functional connectivity between the OFC and general value coding in ventromedial prefrontal cortex (vmPFC) predicted individual differences in satiety-related choice behavior. These findings demonstrate how flexible representations of specific rewards in the OFC are updated by devaluation, and how functional connections to vmPFC reflect the current value of outcomes and guide goal-directed behavior. SIGNIFICANCE STATEMENT The orbitofrontal cortex (OFC) is critical for goal-directed behavior. A recent proposal is that OFC fulfills this function by representing a variety of state and task variables (“cognitive maps”), including a conjunction of expected reward identity and value. Here we tested how identity-specific representations of food odor reward are updated by satiety. We found that fMRI pattern-based signatures of reward identity in lateral posterior OFC were modulated after selective devaluation, and that connectivity between this region and general value coding ventromedial prefrontal cortex (vmPFC) predicted choice behavior. These results provide evidence for a mechanism by which devaluation modulates a cognitive map of expected reward in OFC and thereby alters general value signals in vmPFC to guide goal-directed behavior.
Effects of Verbal Working Memory Load on Corticocortical Connectivity Modeled by Path Analysis of Functional Magnetic Resonance Imaging Data

We investigated the hypothesis that there are load-related changes in the integrated function of frontoparietal working memory networks. Functional magnetic resonance imaging time-series data from 10 healthy volunteers performing a graded n-back verbal working memory task were modeled using path analysis. Seven generically activated regions were included in the model: left/right middle frontal gyri (L/R MFG), left/right inferior frontal gyri (L/R IFG), left/right posterior parietal cortex (L/R PPC), and supplementary motor area (SMA). The model provided a good fit to the 1-back (chi(2) = 7.04, df = 8, P = 0.53) and 2-back conditions (chi(2) = 9.35, df = 8, P = 0.31) but not for the 3-back condition (chi(2) = 20.60, df = 8, P = 0.008). Model parameter estimates were compared overall among conditions: there was a significant difference overall between 1-back and 2-back conditions (chi(2)(diff) = 74.77, df = 20, P < 0.001) and also between 2-back and 3-back conditions (chi(2)(diff) = 96.28, df = 20, P < 0.001). Path coefficients between LIFG and LPPC were significantly different from zero in both 1-back and 2-back conditions; in the 2-back condition, additional paths from LIFG to LPPC via SMA and to RMFG from LMFG and LPPC were also nonzero. This study demonstrated a significant change in functional integration of a neurocognitive network for working memory as a correlate of increased load. Enhanced inferior frontoparietal and prefrontoprefrontal connectivity was observed as a correlate of increasing memory load, which may reflect greater demand for maintenance and executive processes, respectively.
Problems, What Problems? An Examination of the Interactive Relationship of Technology Difficulties and Political Efficacy on Job Satisfaction

We examined the interactive relationship between perceived technology difficulties and political efficacy on employees’ job satisfaction. Technology difficulties refer to the inabilities to maximize usage of the technology. The sample consisted of 325 individuals employed in a wide range of work environments. We hypothesized that political efficacy, which we define as success at achieving outcomes by influencing others, would minimize the harmful effects of technology difficulties on employees’ job satisfaction. Results strongly support our hypothesis. Specifically, individuals with low levels of political efficacy reported lower levels of job satisfaction as technology difficulties increased. Further, job satisfaction increased for high political efficacy individuals as technology difficulties increased. Implications of these results, strengths and limitations of this research, and directions for future research are offered.
Three-Dimensional Analysis of Finlet Kinematics in the Chub Mackerel (Scomber japonicus)

Finlets, which are small non-retractable fins located on the body margins between the second dorsal and anal fins and the caudal fin of scombrid fishes, have been hypothesized to improve swimming performance. The kinematics of three posterior finlets of the chub mackerel, Scomber japonicus, were examined using three-dimensional measurement techniques to test hypotheses on finlet rigidity and function during steady swimming. Finlet bending and finlet planar orientation to the xz, yz, and xy planes were measured during steady swimming at 1.2 lengths s−1 in a flow tank. Despite very similar morphology among the individual finlets, there was considerable variability in finlet flexure during a stroke. Several of the finlets were relatively rigid and flat (with intrafinlet angles close to 180° during the stroke), although intrafinlet angle of the proximal portion of the most posterior finlet varied considerably over the stroke and was as low as 140° midstroke. Finlets showed complex orientations in three-dimensional space over a stroke, and these orientations differed among the finlets. For example, during tail deceleration the proximal portion of the fifth finlet achieves a mean angle of approximately 75° with the xz plane, while the distal portion of this finlet is oriented at 110°. Our data suggest that the trajectory of local water flow varies among finlets and that the most posterior finlet is oriented to redirect flow into the developing tail vortex, which may increase thrust produced by the tail of swimming mackerel.
Morfología de las semillas de las especies del género Trifolium de la Península Ibérica

Se estudia la longitud, anchura, forma, posicion del hilo, profundidad del surco, color y superficie de las semiillas de 54 especies ibericas del genero Trifolium, estudiandose 12 de ellas al microscopio electronico de barrido. Los resultados se discuten desde el punto de vista sistematico poniendo de manifiesto el escaso valor de los parametros estudiados, de los que destacamos la forma, que se discute teniendo en cuenta la foram de dispersion de semillas en cada una de las secciones, asi como el color y la ornamentacion por su valor diagnostico.
Meta-Analysis of the Effect of Insulin Lispro on Severe Hypoglycemia in Patients With Type 1 Diabetes

OBJECTIVE A precise time-action profile of insulin lispro (Humalog) at mealtime may reduce the incidence of severe hypoglycemia. Because it is a rare complication, we performed a cumulative meta-analysis to compare the frequency of severe hypoglycemia during insulin lispro and human regular insulin therapy in type 1 diabetic patients. RESEARCH DESIGN AND METHODS The analysis included eight large multicenter clinical trials, three with parallel and five with crossover designs. The studies included 2,576 type 1 diabetic patients in total, with 2,327 receiving insulin lispro and 2,339 receiving regular human insulin, representing >1,400 patient-years of insulin therapy. Severe hypoglycemia was defined as coma or requiring glucagon or intravenous glucose. The patients received either NPH or ultralente as their basal insulin and insulin lispro or regular human insulin before each meal. RESULTS Seventy-two patients (3.1%) had a total of 102 severe hypoglycemic episodes during insulin lispro therapy, compared with 102 patients (4.4%) with a total of 131 episodes during regular human insulin therapy (P = 0.024). CONCLUSIONS The results of this meta-analysis demonstrate that in type 1 diabetic patients, the frequency of severe hypoglycemia can be reduced by taking insulin lispro as compared with regular human insulin therapy.
Calibration of atomic‐force microscope tips

Images and force measurements taken by an atomic‐force microscope (AFM) depend greatly on the properties of the spring and tip used to probe the sample’s surface. In this article, we describe a simple, nondestructive procedure for measuring the force constant, resonant frequency, and quality factor of an AFM cantilever spring and the effective radius of curvature of an AFM tip. Our procedure uses the AFM itself and does not require additional equipment.
Superresolution Full-polarimetric Imaging for Radio Interferometry with Sparse Modeling

We propose a new technique for radio interferometry to obtain superresolution full-polarization images in all four Stokes parameters using sparse modeling. The proposed technique reconstructs the image in each Stokes parameter from the corresponding full-complex Stokes visibilities by utilizing two regularization functions: the ℓ1 norm and the total variation (TV) of the brightness distribution. As an application of this technique, we present simulated linear polarization observations of two physically motivated models of M87 with the Event Horizon Telescope. We confirm that ℓ1+TV regularization can achieve an optimal resolution of ∼25%–30% of the diffraction limit , which is the nominal spatial resolution of a radio interferometer for both the total intensity (i.e., Stokes I) and linear polarizations (i.e., Stokes Q and U). This optimal resolution is better than that obtained from the widely used Cotton–Schwab CLEAN algorithm or from using ℓ1 or TV regularizations alone. Furthermore, we find that ℓ1+TV regularization can achieve much better image fidelity in linear polarization than other techniques over a wide range of spatial scales, not only in the superresolution regime, but also on scales larger than the diffraction limit. Our results clearly demonstrate that sparse reconstruction is a useful choice for high-fidelity full-polarimetric interferometric imaging.
DustPedia: Multiwavelength Photometry and Imagery of 875 Nearby Galaxies in 42 Ultraviolet--Microwave Bands

The DustPedia project is capitalising on the legacy of the Herschel Space Observatory, using cutting-edge modelling techniques to study dust in the 875 DustPedia galaxies - representing the vast majority of extended galaxies within 3000 km s$^{-1}$ that were observed by Herschel. This work requires a database of multiwavelength imagery and photometry that greatly exceeds the scope (in terms of wavelength coverage and number of galaxies) of any previous local-Universe survey. We constructed a database containing our own custom Herschel reductions, along with standardised archival observations from GALEX, SDSS, DSS, 2MASS, WISE, Spitzer, and Planck. Using these data, we performed consistent aperture-matched photometry, which we combined with external supplementary photometry from IRAS and Planck. We present our multiwavelength imagery and photometry across 42 UV-microwave bands for the 875 DustPedia galaxies. Our aperture-matched photometry, combined with the external supplementary photometry, represents a total of 21,857 photometric measurements. A typical DustPedia galaxy has multiwavelength photometry spanning 25 bands. We also present the Comprehensive & Adaptable Aperture Photometry Routine (CAAPR), the pipeline we developed to carry out our aperture-matched photometry. CAAPR is designed to produce consistent photometry for the enormous range of galaxy and observation types in our data. In particular, CAAPR is able to determine robust cross-compatible uncertainties, thanks to a novel method for reliably extrapolating the aperture noise for observations that cover a very limited amount of background. Our rich database of imagery and photometry is being made available to the community
Radius of gyration of plasmid DNA isoforms from static light scattering

Despite the extensive interest in applications of plasmid DNA, there have been few direct measurements of the root mean square radius of gyration, RG, of different plasmid isoforms over a broad range of plasmid size. Static light scattering data were obtained using supercoiled, open‐circular, and linear isoforms of 5.76, 9.80, and 16.8 kbp plasmids. The results from this study extend the range of RG values available in the literature to plasmid sizes typically used for gene therapy and DNA vaccines. The experimental data were compared with available theoretical expressions based on the worm‐like chain model, with the best‐fit value of the apparent persistence length for both the linear and open‐circular isoforms being statistically identical at 46 nm. A new expression was developed for the radius of gyration of the supercoiled plasmid based on a model for linear DNA using an effective contour length that is equal to a fraction of the total contour length. These results should facilitate the development of micro/nano‐fluidic devices for DNA manipulation and size‐based separation processes for plasmid DNA purification. Biotechnol. Bioeng. 2010;107: 134–142. © 2010 Wiley Periodicals, Inc.
Resilience and corpus callosum microstructure in adolescence

Background Resilience is the capacity of individuals to resist mental disorders despite exposure to stress. Little is known about its neural underpinnings. The putative variation of white-matter microstructure with resilience in adolescence, a critical period for brain maturation and onset of high-prevalence mental disorders, has not been assessed by diffusion tensor imaging (DTI). Lower fractional anisotropy (FA) though, has been reported in the corpus callosum (CC), the brain's largest white-matter structure, in psychiatric and stress-related conditions. We hypothesized that higher FA in the CC would characterize stress-resilient adolescents. Method Three groups of adolescents recruited from the community were compared: resilient with low risk of mental disorder despite high exposure to lifetime stress (n = 55), at-risk of mental disorder exposed to the same level of stress (n = 68), and controls (n = 123). Personality was assessed by the NEO-Five Factor Inventory (NEO-FFI). Voxelwise statistics of DTI values in CC were obtained using tract-based spatial statistics. Regional projections were identified by probabilistic tractography. Results Higher FA values were detected in the anterior CC of resilient compared to both non-resilient and control adolescents. FA values varied according to resilience capacity. Seed regional changes in anterior CC projected onto anterior cingulate and frontal cortex. Neuroticism and three other NEO-FFI factor scores differentiated non-resilient participants from the other two groups. Conclusion High FA was detected in resilient adolescents in an anterior CC region projecting to frontal areas subserving cognitive resources. Psychiatric risk was associated with personality characteristics. Resilience in adolescence may be related to white-matter microstructure.
Lues Maligna: Presentation of a Case and a Review of the Literature

A case of lues maligna, an unusual form of secondary syphilis is presented. The primary clinical features of the disease were ulcerating skin lesions with rupioid crusting, and a strongly reactive VDRL. Biopsy showed an obliterative vasculitis. Oral tetracycline effected rapid resolution of the lesions. The hypothesis is presented that the disease represents a progressive form of papulopustular secondary syphilis. Poor nutrition and generalized debility is a feature of many of the cases and may be of etiological significance.
11 2 Evolutionary Algorithms in Drug Design

Designing a drug is the process of finding or creating a molecule which has a specific activity on a biological organism. Drug design is difficult since there are only few molecules that are both effective against a certain disease and exhibit other necessary physiological properties, such as absorption by the body and safety of use. The main problem of drug design is therefore how to explore the chemical space of many possible molecules to find the few suitable ones. Computational methods are increasingly being used for this purpose, among them evolutionary algorithms. This review will focus on the applications of evolutionary algorithms in drug design, in which evolutionary algorithms are used both to create new molecules and to construct methods for predicting the properties of real or yet unexisting molecules. We will also
Uncovering Active Constituents Responsible for Different Activities of Raw and Steamed Panax notoginseng Roots

Although Panax notoginseng (PN) roots in raw and steamed forms were historically supposed to be different in the efficacies, the raw materials and steamed ones were often undifferentiated in the use and market circulation, which might bring unstable curative effects or even adverse reactions. To uncover chemical constituents responsible to different activities of raw and steamed PN, chemometrics analyses including partial least squares regression (PLSR) and multi-linear regression analysis (MLRA) were used to establish the relationships between the chromatographic fingerprints and activities of PN samples. Chemical fingerprints of PN were determined by HPLC. Anticoagulant and antioxidant activities were evaluated by the thromboplastin inhibiting test and hydroxyl radical scavenging assay, respectively. Results showed that there was a significant difference in the chemical composition between raw and steamed PN, which could be discriminated by principle component analysis according to different steaming temperatures. Compared with the steamed PN, raw PN exhibited stronger anticoagulation and weaker antioxidation. By chemometrics analyses, notoginsenoside R1, ginsenosides Rg1, Re, Rb1, and Rd were found to be the major active constituents of raw PN, whereas ginsenosides Rh1, Rk3, Rh4, and 20(R)-Rg3 had the key role in the activities of steamed PN, which could be used as new markers for the quality control (QC) of steamed PN.
Role of Basement Membranes in Cell Differentiation

Extracellular matrices have diverse biological effects, including promoting the growth and differentiation of various cells of epithelial origin. The components of one of these matrices, the basement membrane, are discussed, as well as studies using these components alone or in combination with cells in culture. The particular response observed varies with the cell type examined and appears to be dependent on multiple interactions with components of the matrix. Potential uses for a basement membrane-derived matrix in vitro and in vivo are being developed.
Molecular epidemiology of the emerging human malaria parasite “Plasmodium knowlesi”

Malaria is the most important parasitic disease with global concern. Plasmodium knowlesi recently has emerged from its natural simian host as a significant cause of human malaria, particularly in Malaysian Borneo. Therefore, it has been added as the fifth human Plasmodium specie which is widely distributed in Southeast Asia. Recent developments of new molecular tools enhanced our understanding about the key features of this malaria parasite. Here, we review some of the ways in which molecular approaches might be used for epidemiology of P. knowlesi and finally lead to an efficient control of malaria.
Spectral functions of the uniform electron gas via coupled-cluster theory and comparison to the GW and related approximations

We use ab initio coupled-cluster theory to compute the spectral function of the uniform electron gas at a Wigner-Seitz radius of r_s=4. The coupled-cluster approximations we employ go significantly beyond the diagrammatic content of state-of-the-art GW theory. We compare our calculations extensively to GW and GW-plus-cumulant theory, illustrating the strengths and weaknesses of these methods in capturing the quasiparticle and satellite features of the electron gas. Our accurate calculations further allow us to address the long-standing debate over the occupied bandwidth of metallic sodium. Our findings indicate that the future application of coupled-cluster theory to condensed phase material spectra is highly promising.
Hunters at Hengistbury: Some evidence from experimental archaeology

Abstract The first part of this paper describes arrow‐firing experiments using copies of English Mesolithic points slotted into arrowshafts and shot into an animal carcass. ‘Impact fractures’ on the experimental flint points are compared with breakages observed on several microliths from the Powell Mesolithic site at Hengistbury Head, in Dorset. In the second part, the authors examine artefact distribution patterns from the Mace/Campbell Upper Palaeolithic site at Hengistbury and compare them briefly with those from the Belgian site of Meer, also in sands. In addition, some recent flint‐scatter experiments in sands are described and their relevance to site formation processes discussed.
Multi‐locus species delimitation in closely related animals and fungi: one marker is not enough

Despite taxonomy’s 250‐year history, the past 20 years have borne witness to remarkable advances in technology and techniques, as well as debate. DNA barcoding has generated a substantial proportion of this debate, with its proposition that a single mitochondrial sequence will consistently identify and delimit species, replacing more evidence‐rich and time‐intensive methods. Although mitochondrial DNA (mtDNA) has since been the focus of voluminous discussion and case studies, little effort has been made to comprehensively evaluate its success in delimiting closely related species. We have conducted the first broadly comparative literature review addressing the efficacy of molecular markers for delimiting such species over a broad taxonomic range. By considering only closely related species, we sought to avoid confusion of success rates with those due to deeply divergent taxa. We also address whether increased population‐level or geographic sampling affects delimitation success. Based on the results from 101 studies, we found that all marker groups had approximately equal success rates (∼70%) in delimiting closely related species and that the use of additional loci increased average delimitation success. We also found no relationship between increased sampling of intraspecific variability and delimitation success. Ultimately, our results support a multi‐locus integrative approach to species delimitation and taxonomy.