Miracle-dz/UniFAR-FTUs huggingface dataset:
A randomized controlled trial of the effects of intensive sit-to-stand training after recent traumatic brain injury on sit-to-stand performance

Objective: To examine the effectiveness of intensive practice of sit-to-stand on motor performance, exercise capacity and exercise efficiency in traumatic brain-injured patients during early inpatient rehabilitation. Design: Single-blind randomized controlled pilot study. Setting: Brain injury rehabilitation unit. Subjects: Twenty-four subjects who had recently sustained a severe traumatic brain injury (TBI) were randomized into an experimental (n = 13) and a control (n = 11) group. Interventions: In addition to their usual rehabilitation programme, subjects in the experimental group participated in four weeks of intensive training of sit-to-stand and step-up exercises with the aim of improving performance of sit-to-stand. The control group did no additional sit-to-stand or step-up training. Main outcome measures: Total number of sit-to-stands in 3 min as a measure of motor performance; peak oxygen consumption during a maximal 3-min sit-to-stand test (VO2peak) as a measure of exercise capacity; oxygen consumption during a 3-min equivalent workload sit-to-stand test (VO2equiv) as a measure of exercise efficiency. Pre- and post-training measurements were made. Results: The exercise programme resulted in a 62% improvement in motor performance (number of repetitions of sit-to-stand in 3 min) for the experimental group compared with the control group's 18% improvement (p < 0.05). There was no significant difference between groups for changes in exercise capacity or efficiency. In the experimental group, the increase in VO2peak from pre-test to post-test correlated with the increase in sit-to-stand repetitions (p < 0.05). Conclusions: Intensive task-specific training is recommended as an important component of rehabilitation early following severe traumatic brain injury.
Pollinating fig wasp Ceratosolen solmsi adjusts the offspring sex ratio to other foundresses

Abstract Local mate competition theory predicts that offspring sex ratio in pollinating fig wasps is female‐biased when there is only one foundress, and increased foundress density results in increased offspring sex ratio. Information of other foundresses and clutch size have been suggested to be the main proximate explanations for sex ratio adjustment under local mate competition. Our focus was to show the mechanism of sex ratio adjustment in a pollinating fig wasp, Ceratosolen solmsi Mayr, an obligate pollinator of the functionally dioecious fig, Ficus hispida Linn. , with controlled experiments in the field. First, we obtained offspring from one pollinator and offspring at different oviposition sequences, and found that offspring sex ratio decreased with clutch size, and pollinators produced most of their male offspring at the start of bouts, followed by mostly females. Second, we found that offspring sex ratio increased with foundress density, and pollinators did adjust their offspring sex ratio to other females in the oviposition patches. We suggest that when oviposition sites are not limited, pollinators will mainly adjust their offspring sex ratio to other foundresses independent of clutch size changes, whereas adjusting clutch size may be used to adjust sex ratio when oviposition sites are limited.
A review of pramipexole and its clinical utility in Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disorder characterised by selective loss of dopaminergic neurones in the substantia nigra and resulting in progressive disability. Therapy has focused on replacing depleted dopamine (DA) via supplementation with levodopa or DA agonists. Pramipexole (Mirapex®, Pharmacia Corp.) has recently been approved for the treatment of PD. Evidence from preclinical studies and clinical trials have proven the effectiveness of this agent in ameliorating the symptoms of PD. There is also non-human evidence that pramipexole may be neuroprotective and could therefore possibly slow disease progression; however, this has yet to be proven in humans. The use of pramipexole may be limited by its side effect profile compared to standard therapies and its relatively higher cost compared to levodopa. Despite these concerns, pramipexole does have a role in the treatment of PD in all stages of the illness and may arguably be the treatment of choice in early disease. In addition to its use in PD, pramipexole has shown some utility in the treatment of restless legs syndrome (RLS), depression and schizophrenia.
Running head : NURSING CARE DURING SECOND STAGE OF LABOR 1 Evidence-Based Recommendations for Nursing Care during the Second Stage of Labor A Best Practice Approach

The purpose of this thesis was to develop best practice recommendations to care for women in the second stage of labor. Evidence suggests that care of women during the second stage of labor using upright positioning, delayed pushing, application of warm compresses to the perineum, and perineal massage can improve maternal and neonatal outcomes (Aasheim et al., 2011; Brancato et al., 2008; Chang et al., 2011; Dahlen et al., 2007; Dahlen et al., 2009; Gillesby et al., 2010; Gupta et al., 2012; Kelly et al., 2010; Sanders et al., 2005; Schaub et al., 2008; Simpson & James, 2005; Terry et al., 2006; Thies-Lagergren et al., 2013). A theoretical plan for implementation and evaluation of best practice recommendations for the second stage of labor was discussed in this paper. Registered nurses implementing evidence-based recommendations within the hospital setting for pregnant women regarding delayed pushing, upright labor positions, and interventions to reduce perineal trauma and pain, would provide women care that may improve second stage of labor outcomes. NURSING CARE DURING SECOND STAGE OF LABOR 3 CHAPTER
Performance modeling of FEC‐based unequal error protection for H.264/AVC video streaming over burst‐loss channels

Unequal error protection systems are a popular technique for video streaming. Forward error correction (FEC) is one of error control techniques to improve the quality of video streaming over lossy channels. Moreover, frame‐level FEC techniques have been proposed for video streaming because of different priority video frames within the transmission rate constraint on a Bernoulli channel. However, various communication and storage systems are likely corrupted by bursts of noise in the current wireless behavior. If the burst losses go beyond the protection capacity of FEC, the efficacy of FEC can be degraded. Therefore, our proposed model allows an assessment of the perceived quality of H.264/AVC video streaming over bursty channels, and is validated by simulation experiments on the NS‐2 network simulator at a given estimate of the packet loss ratio and average burst length. The results suggest a useful reference in designing the FEC scheme for video applications, and as the video coding and channel parameters are given, the proposed model can provide a more accurate evaluation tool for video streaming over bursty channels and help to evaluate the impact of FEC performance on different burst‐loss parameters. Copyright © 2014 John Wiley & Sons, Ltd.
Genetic rearrangement associated with in vivo mucoid conversion of Pseudomonas aeruginosa PAO is due to insertion elements

The conversion of Pseudomonas aeruginosa PAO to the mucoid phenotype has been reported for a chronic pulmonary infection model in rats (D. E. Woods, P. A. Sokol, L. E. Bryan, D. G. Storey, S. J. Mattingly, H. J. Vogel, and H. Ceri, J. Infect. Dis. 163:143-149, 1991). This conversion was associated with a genetic rearrangement upstream of the exotoxin A gene. To characterize the genetic rearrangement, the region upstream of the toxA gene was cloned from PAO, PAO-muc (a mucoid strain), and PAO-rev (a nonmucoid revertant strain). The nucleotide sequence of a 4.8-kb fragment from PAO-muc was determined. A+T-rich regions of approximately 2 kb (IS-PA-4) and 0.4 kb (IS-PA-5) were identified in this fragment. DNA probes constructed internal to these regions hybridized to PAO-muc but not to PAO or PAO-rev, suggesting that PAO-muc contains an insertion element. Sequence analysis of the nonmucoid clones indicated that a 2,561-bp fragment corresponding to IS-PA-4 and a 992-bp fragment corresponding to IS-PA-5 were not present in PAO or PAO-rev. Both nonmucoid clones, however, contained in the same location as IS-PA-4, a 1,313-bp region which was not present in PAO-muc. DNA probes complementary to this sequence, designated IS-PA-6, did not hybridize with PAO-muc, indicating that this sequence had been replaced upon conversion to the mucoid phenotype. Between IS-PA-4 and IS-PA-5 there was a 500-bp sequence which was 94% identical to the 500-bp sequence downstream of IS-PA-6. These insertion elements had some DNA sequence similarity to plasmid and transposon sequences, suggesting that they may be of plasmid origin. IS-PA-4 and IS-PA-5 were shown also to be present in two mucoid isolates from cystic fibrosis patients. The insertions occurred in the same location upstream of the toxA gene, suggesting that this type of genetic recombination may also be associated with mucoid conversion in some P. aeruginosa clinical isolates.
Endothelial Cell–Derived Microparticles in Allogeneic Hematopoietic Stem Cell Recipients

Background. Alterations of microparticles derived from different cell types are described in a number of diseases associated with inflammation and hemostatic disorders. Methods. In this prospective study, we firstly analyzed endothelial cell derived microparticles (EMP) in 19 hematopoietic stem cell recipients. Cultured human umbilical vein endothelial cells (HUVEC) stimulated with tumor necrosis factor-alpha (TNF-alpha) served as positive controls. EMP were analyzed by fluorescent activated cell sorting (FACS), detecting the particels via expression of CD62 (E-selectin) and anionic phospholipids binding to annexin V. Results. EMP were not significantly influenced by conditioning regimens with non-myeloablative chemotherapy and 4 Gy total body irradiation (TBI) or by myeloablative regimens containing 12 Gy TBI. During acute graft versus host disease (aGVHD), significantly higher levels of EMP were detected than in patients without aGVHD (18.5/&mgr;l s=10.1 vs. 14.6/&mgr;l SD=11.5; P=0.004) while infectious complications did not alter EMP levels significantly. Immunosuppressive therapy with corticosteroids tendentially elevated EMP levels. HUVEC treated with TNF-alpha 1 ng/ml, 10 ng/ml and 100 ng/ml released significantly more EMP than unstimulated cultures (30.0/&mgr;l ss=13.6 vs. 126.8/&mgr;l SD=66.9, P=0.032 / vs. 683.3/&mgr;l SD=349.9; P=0.03 / vs. 489.3 s=184.4; P=0.013). Conclusions. Elevation of EMP during aGVHD might express severe endothelial cell injury within this complication after hematopoietic stem cell transplantation and might serve as a diagnostic test for early differentiation of aGVHD from other transplanted related complications.
Bone marrow transplantation versus chemotherapy for maintenance of second remission of childhood acute lymphoblastic leukemia: a study of the Children's Cancer Group (CCG-1884).

BACKGROUND Maintenance of second remission of childhood acute lymphoblastic leukemia (ALL) with intensive chemotherapy is often unsuccessful. The major cause of treatment failure is relapse. MATERIALS AND METHODS Of 96 children with ALL who relapsed in the marrow while on or within 1 year of completing initial therapy, 62 achieved a second remission. Nineteen patients underwent bone marrow transplantation in second remission, 11 from a human leukocyte antigen (HLA)-matched related donor, seven using autologous marrow, and one from a matched unrelated donor. The event-free survival (EFS) of transplanted patients was compared to that of patients treated with intensive chemotherapy using high-dose cytarabine, vincristine, escalating dose methotrexate, L-asparaginase, and an anthracycline (daunorubicin or idarubicin). Only those patients treated with chemotherapy who survived in second remission up to the mean time that patients were transplanted (135 days) were included in the control group (33 of 43 patients who achieved second remission). RESULTS The actuarial 2-year event-free survival of transplanted patients is 37+/-22% (95% C.I.) compared to 18+/-13% for chemotherapy-treated patients (P=0.017). EFS for allo-transplant recipients was similar to that for auto-transplant recipients. Duration of initial remission was a strong predictor of the outcome of retrieval therapy. Patients whose initial remission was greater than 3 years had better EFS after achieving second remission (five of 11 still in remission, compared to four of 41 patients whose initial remission was less than 3 years). Adjustment in the multivariate analysis for duration of initial remission did not diminish the benefit of transplant over chemotherapy. CONCLUSIONS While there remains considerable possibility for further improvement in EFS after achieving second remission of childhood ALL, bone marrow transplant is superior to chemotherapy in maintaining second remission.
Trait and state anxiety: Relations to executive functioning in an at-risk sample

Prior research with adults suggests mixed evidence for the relations of state and trait anxiety to prefrontal executive functions (EF). Trait anxiety is hypothesised to impair the efficiency of prefrontal areas and goal-directed attention and has been largely associated with poorer performance on executive functioning tasks. Fewer studies have investigated state anxiety, and the findings have been mixed. As studies of these processes in children have been limited by small sample sizes and a focus on working memory, we examine whether state and trait anxiety are associated with performance on two EF tasks in a sample of urban, low-income children, ages 9–12. Results indicated that higher trait anxiety predicted lower executive functioning on both tasks. In addition, higher state anxiety was related to better performance on the Stroop task. Results demonstrate that, consistent with the adult literature, higher trait anxiety is related to lower executive functioning in children.
The Incidence of Subsequent Meniscal Surgery Is Higher in the Anterior Cruciate Ligament–Reconstructed Knee Than in the Contralateral Knee

Background: A goal of anterior cruciate ligament (ACL) reconstruction is to provide a meniscal protective effect for the knee. Purpose: (1) To evaluate whether there was a different likelihood of subsequent meniscal surgery in the ACL-reconstructed knee or in the normal contralateral knee and (2) to compare the risk factors associated with subsequent meniscal surgery in the ACL-reconstructed knee and contralateral knee. Study Design: Cohort study; Level of evidence, 3. Methods: Using an integrated health care system’s ACL reconstruction registry, patients undergoing primary ACL reconstruction, with no meniscal injury at the time of index surgery and a normal contralateral knee, were evaluated. Subsequent meniscal tears associated with ACL graft revision were excluded. Subsequent meniscal surgery in either knee was the outcome of interest. Sex, age, and graft type were assessed as potential risk factors. Survival analysis was used to compare meniscal surgery–free survival rates and to assess risk factors of subsequent meniscal surgery. Results: Of 4087 patients, there were 32 (0.78%) patients who underwent subsequent meniscal surgery in the index knee and 9 (0.22%) in the contralateral knee. The meniscal surgery–free survival rate at 4 years was 99.08% (95% CI, 98.64%-99.37%) in the index knee and 99.65% (95% CI, 99.31%-99.82%) in the contralateral knee. There was a 3.73 (95% CI, 1.73-8.04; P < .001) higher risk of subsequent meniscal surgery in the index knee compared with the contralateral knee, or a 0.57% absolute risk difference. After adjustments, allografts (hazard ratio [HR], 5.06; 95% CI, 1.80-14.23; P = .002) and hamstring autografts (HR, 3.11; 95% CI, 1.06-9.10; P = .038) were risk factors for subsequent meniscal surgery in the index knee compared with bone–patellar tendon–bone (BPTB) autografts. Conclusion: After ACL reconstruction, the overall risk of subsequent meniscal surgery was low. However, the relative risk of subsequent meniscal surgery in the ACL-reconstructed knee was higher compared with the contralateral knee. Only graft type was found to be a risk factor for subsequent meniscal surgery in the ACL-reconstructed knee, with a higher risk for allografts and hamstring autografts compared with BPTB autografts.
Avaliação do pH e Atividade de àgua em Produtos Cárneos

Mediu-se pH e atividade de agua de produtos carneos comerciais com objetivo de avaliar a seguranca destes produtos quanto ao desenvolvimento de patogenos. Conclui-se que existem produtos onde a tecnologia dos obstaculos nao esta sendo utilizada ficando a seguranca dependente de apenas um fator , sinalizando a necessidade de conscientizacao dos comerciantes pelas industrias e atuacao dos orgaos de fiscalizacao.
Assessment of Accuracy of Identification of Pathogenic Yeasts in Microbiology Laboratories in the United Kingdom

ABSTRACT Rapid, accurate identification of yeast isolates from clinical samples has always been important given their innately variable antifungal susceptibility profiles. Recently, this has become paramount with the proposed introduction of species-specific interpretive breakpoints for MICs obtained in yeast antifungal susceptibility tests (M. A. Pfaller, D. Andes, D. J. Diekema, A. Espinel–Ingroff, D. Sheehan, and CLSI Subcommittee for Antifungal Susceptibility Testing, Drug Resist. Updat. 13:180–195, 2010). Here, we present the results of a 12-month evaluation of the accuracy of identifications that accompany yeast isolates submitted to the Mycology Reference Laboratory (United Kingdom) for either confirmation of identity or susceptibility testing. In total, 1,781 yeast isolates were analyzed, and the robustness of prior identifications obtained in microbiology laboratories throughout the United Kingdom was assessed using a combination of culture on chromogenic agar, morphology on cornmeal agar, and molecular identification by pyrosequencing. Over 40% of isolates (755) were submitted without any suggested identification. Of those isolates with a prior identification, 100 (9.7%) were incorrectly identified. Error rates ranged from 5.2% (for organisms submitted for antifungal susceptibility testing) to 18.2% (for organisms requiring confirmation of identity) and varied in a strictly species-specific manner. At least 50% of identification errors would be likely to affect interpretation of MIC data, with a possible impact on patient management. In addition, 2.3% of submitted cultures were found to contain mixtures of at least two yeast species. The vast majority of mixtures had gone undetected in the referring laboratory and would have impacted the interpretation of antifungal susceptibility profiles and patient management. Some of the more common misidentifications are discussed according to the identification method employed, with suggestions for avoiding such misinterpretations.
Facing the Bogey : Women , Football and Sexuality

This article examines the implications for football players of the way in which women’s sport is regularly framed within discourses of sexuality. It focuses on a premier league football team in New Zealand comprised of both homosexually and heterosexually identified women. Interviews with players reveal the extent to which homophobia is associated with women’s experiences of football and is something that all players have had to confront. While homophobia within women’s football can be reduced through the increased visibility of lesbian players and interactions with their heterosexual team-mates, homo-negativity from outside the team is experienced at two levels, based on irrational judgements and purposeful intimidating behaviour directed at sportswomen.
From Intervention to Outcome: The Relationship between Knowledge and Behavior in a Trachoma Control Project

The fundamental problem for evaluating social health interventions is the relationship between the health promotion effort, behavior change, and subsequent disease outcomes. Trachoma, Chlamydia trachomatis, an infection of the eye, is the leading cause of preventable blindness in the world. Trachoma is hyper-endemic among the rural population of the Egyptian Delta. From 1990 through 1991 an Egyptian–American health intervention was conducted to increase the number of children who had their faces washed with soap and water at least once each day, a behavior known to reduce the risk of active infection.
Large Larmor radius stability of the z pinch.

The linear [ital m]=0 stability of the [ital z] pinch in the collisionless, large ion Larmor radius regime is examined using the Vlasov fluid model. The results reveal a strong equilibrium dependence. The uniform current density equilibrium shows a reduction in growth rate when the average ion Larmor radius is about one-fifth of the pinch radius. However, finite Larmor radius effects cannot in themselves produce a stabilized [ital z] pinch.
Treatment of diffuse proliferative lupus nephritis: a meta-analysis of randomized controlled trials.

BACKGROUND In this systematic review of randomized controlled trials (RCTs), we assess the benefits and harm of current treatments for diffuse proliferative lupus nephritis (DPLN). METHODS The Cochrane Controlled Trial Registry, MEDLINE, and EMBASE were searched for RCTs of treatment for DPLN. All available RCTs of patients with biopsy-proven DPLN were included, and data were extracted for overall mortality, end-stage renal disease, doubling of serum creatinine level, relapse, major infection, herpes zoster infection, ovarian failure, malignancy, and bladder toxicity. Treatment effects on these outcomes were summarized as relative risk (RR) with 95% confidence interval (CI) and pooled by using a random-effects model. RESULTS Twenty-five of 920 articles identified were eligible RCTs and were included. The majority compared cyclophosphamide or azathioprine plus steroids versus steroids alone. Cyclophosphamide plus steroids reduced the risk for doubling of serum creatinine level (4 RCTs, 228 patients; RR, 0.59; 95% CI, 0.40 to 0.88) compared with steroids alone, but had no impact on overall mortality (5 RCTs, 226 patients; RR, 0.98; 95% CI, 0.53 to 1.82). However, risk for ovarian failure was increased significantly (3 RCTs, 147 patients; RR, 2.18; 95% CI, 1.10 to 4.34). In studies from the 1970s, azathioprine plus steroids reduced the risk for all-cause mortality compared with steroids alone (3 RCTs, 78 patients; RR, 0.60; 95% CI, 0.36 to 0.99), but had no effect on renal outcomes. Neither therapy was associated with increased risk for major infection. The addition of plasma exchange to these treatments offered no benefit, and information on other agents, including mycophenolate mofetil, was insufficient for analysis. CONCLUSION Until future RCTs of newer agents are completed, the current use of cyclophosphamide combined with steroids remains the best option to preserve renal function in patients with DPLN. The smallest effective dose and shortest duration of treatment should be used to minimize gonadal toxicity without compromising efficacy.
LoRaWAN in the Wild: Measurements from The Things Network

The Long-Range Wide-Area Network (LoRaWAN) specification was released in 2015, primarily to support the Internet-of-Things by facilitating wireless communication over long distances. Since 2015, the role-out and adoption of LoRaWAN has seen a steep growth. To the best of our knowledge, we are the first to have extensively measured, analyzed, and modeled the performance, features, and use cases of an operational LoRaWAN, namely The Things Network. Our measurement data, as presented in this paper, cover the early stages up to the production-level deployment of LoRaWAN. In particular, we analyze packet payloads, radio-signal quality, and spatio-temporal aspects, to model and estimate the performance of LoRaWAN. We also use our empirical findings in simulations to estimate the packet-loss.