Miracle-dz/UniFAR-FTUs huggingface dataset:
Total Abdominal 18F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

Apc mutant (ApcMin) mice develop multiple adenomas in their intestines and are widely used to study colorectal carcinogenesis and chemopreventive approaches. Molecular imaging of intestinal adenomas could potentially provide noninvasive longitudinal evaluation of these lesions in living mice. Therefore, the aim of this study was to investigate the role of 18F-FDG PET in the ApcMin mouse model. Methods: ApcMin mice (n = 8) fed a purified diet were imaged serially after injection of 18F-FDG at age 9 and 12 wk using a small-animal PET scanner. Abdominal uptake of the tracer was quantified. After dissection, intestines were imaged separately, and intestinal tracer uptake was quantified. Tracer distribution was compared with results from microscopic examination regarding adenoma number and size. Thereafter, findings were validated serially in 20 ApcMin mice aged 6, 8, 10, and 12 wk that received standard chow to increase adenoma numbers. In vivo abdominal 18F-FDG uptake was correlated with microscopy results. Results: Microscopic examination showed that the mice developed 25–35 intestinal adenomas at age 12 wk. Ex vivo 18F-FDG PET of the dissected intestines visualized all large adenomas and most small adenomas. Ex vivo total intestinal 18F-FDG uptake correlated with in vivo total abdominal uptake and with the number of large adenomas at age 9 and 12 wk. At 12 wk, there was a clear correlation between in vivo abdominal tracer uptake and the number of large adenomas but not the total number of lesions. Conclusion: Intestinal adenomas in ApcMin mice are metabolically active lesions that take up 18F-FDG. Abdominal 18F-FDG uptake at age 12 wk serves as a readout modality for large intestinal adenomas.
Does a palliative care clinic have a role in improving end-of-life care? Results of a pilot program.

OBJECTIVE To assess the efficacy of a palliative care clinic (PCC), which provided some of the interdisciplinary services and expertise of an inpatient consult service to outpatients, in traditional clinic sessions. DESIGN Chart review. SETTING A large urban Veterans Administration Medical Center. PATIENTS One hundred patients referred to clinic. INTERVENTIONS Palliative care clinic. OUTCOME MEASURES Patients' reported needs, Global Distress Index (GDI) subscale, hospice eligibility, and time to death. RESULTS The most common diagnosis was cancer (n = 85). Most patients (n = 89) had at least one need for services that the team provided (median, 2; range, 0-4), the most common of which was a desire for information about prognosis (n = 84). In a Cox proportional hazards model, predictors of enrollment in hospice included white ethnicity (hazard ratio, 3.42; p < 0.001), a need for help around the home (hazard ratio, 3.26; p = 0.002), and insufficient money left at the end of the month (hazard ratio, 2.39; p = 0.014). CONCLUSIONS The experience of the PCC described here offers a unique approach to improving end-of-life care for those outpatients who may not be well served by existing structures of care such as palliative care consult services and who have not yet enrolled in hospice.
[Association between the rates of low birth-weight and/or preterm infants and aircraft noise exposure].

OBJECTIVES Intense noise exposure having been observed in vicinal areas around the U.S. military airfields in Okinawa, Japan, suggests the possibility of adverse effects on fetal growth, as studies have reported such effects around other airfields. This study analyzes the birth records in Okinawa prefecture and investigates whether lower birth weights of infants and shorter gestation periods are observed around the airfields. METHODS The records of 160,460 births in 15 municipalities around the Kadena and Futenma airfields from 1974 to 1993 were subjected to analysis. Average WECPNL among residents in each municipality was calculated as a measure of noise exposure, since the birth records did not contain information on precise birth addresses but only the municipalities. The odds ratios of low birth weight, i.e. under 2,500 grams, and preterm birth, i.e. less than 37 weeks, were obtained by multiple logistic regression analysis with adjustment for the primary factors that would be related to fetal growth. The factors included sex, maternal age, live birth order, occupation of householder, legitimacy of the infant, year of birth and interaction between maternal age and live birth order. RESULTS The logistic regression analysis showed a significant dose-response relationship between low birth weight and noise exposure. The significance probability of trend test was less than 0.0001. The adjusted odds ratio was 1.3 in the highest noise exposure area, which was Kadena Town, located in the immediate vicinity of the Kadena airfield. Significantly higher rates of preterm births were also found across the noise exposed municipalities. Although the obtained results were not adjusted for some confounding factors like smoking habit, another survey conducted by the present authors did not show particular differences in the female smoking rate between Kadena Town and the other municipalities around the Kadena airfield. CONCLUSION Aircraft noise exposure is most likely to cause adverse effects on fetal growth, raising the rates of low birth weight and preterm infants around the Kadena airfield.
Towards a Linking of FrameNet and SUMO

Most end-user applications of natural language processing such as question answering or information retrieval – and especially a research-oriented task like textual entailment – need to process entailment and contradiction in one way or another. In order to detect entailment and contradiction, a system needs to access very different kinds of resources, such as lexicons, semantic word nets or knowledge ontologies. One such knowledge ontology is SUMO. SUMO represents upper-model knowledge in an abstract way, using a lisp-like format whose expressivity equals that of first-order logic. A direct connection between the syntactic level in the form of free or syntactically preprocessed text and the semantics in the form of SUMO does not exist. There is no obvious way to represent the information contained in a text or sentence using SUMO. This thesis is concerned with this syntax-semantics interface. We will propose an algorithm that combines FrameNet and SUMO. Methods and tools to achieve FrameNet annotations of a given sentence do exist already. Our combination algorithm is based on this FrameNet annotation and links frames to SUMO concepts and frame elements to SUMO relations.
The detection of iron sulfides in Planetary Nebulae

We present and discuss the detection, through mid IR spectroscopy, of iron sulfides in the carbon rich ejecta of evolved stars. We find the spectroscopic signature of iron sulfides at 23m. We also find weak features at 34, 38 and 44m. The positions of these features correspond well with the resonances of the iron sulfide troilite. However, the relative strength of the 23m versus the other bands does not match the laboratory measurements, which suggests the presence of other iron sulfides besides troilite. The same broad feature around 23m has been found in young stellar objects. This detection may imply a carbon star origin for part of the iron sulfides found in meteorites and interplanetary dust particles.
Serum Metabolomic Profiling Reveals Biomarkers for Early Detection and Prognosis of Esophageal Squamous Cell Carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common aggressive malignancies worldwide, particularly in northern China. The absence of specific early symptoms and biomarkers leads to late-stage diagnosis, while early diagnosis and risk stratification are crucial for improving overall prognosis. We performed UPLC-MS/MS on 450 ESCC patients and 588 controls consisting of a discovery group and two validation groups to identify biomarkers for early detection and prognosis. Bioinformatics and clinical statistical methods were used for profiling metabolites and evaluating potential biomarkers. A total of 105 differential metabolites were identified as reliable biomarker candidates for ESCC with the same tendency in three cohorts, mainly including amino acids and fatty acyls. A predictive model of 15 metabolites [all-trans-13,14-dihydroretinol, (±)-myristylcarnitine, (2S,3S)-3-methylphenylalanine, 3-(pyrazol-1-yl)-L-alanine, carnitine C10:1, carnitine C10:1 isomer1, carnitine C14-OH, carnitine C16:2-OH, carnitine C9:1, formononetin, hyodeoxycholic acid, indole-3-carboxylic acid, PysoPE 20:3, PysoPE 20:3(2n isomer1), and resolvin E1] was developed by logistic regression after LASSO and random forest analysis. This model held high predictive accuracies on distinguishing ESCC from controls in the discovery and validation groups (accuracies > 89%). In addition, the levels of four downregulated metabolites [hyodeoxycholic acid, (2S,3S)-3-methylphenylalanine, carnitine C9:1, and indole-3-carboxylic acid] were significantly higher in early cancer than advanced cancer. Furthermore, three independent prognostic markers were identified by multivariate Cox regression analyses with and without clinical indicators: a high level of MG(20:4)isomer and low levels of 9,12-octadecadienoic acid and L-isoleucine correlated with an unfavorable prognosis; the risk score based on these three metabolites was able to stratify patients into low or high risk. Moreover, pathway analysis indicated that retinol metabolism and linoleic acid metabolism were prominent perturbed pathways in ESCC. In conclusion, metabolic profiling revealed that perturbed amino acids and lipid metabolism were crucial metabolic signatures of ESCC. Both panels of diagnostic and prognostic markers showed excellent predictive performances. Targeting retinol and linoleic acid metabolism pathways may be new promising mechanism-based therapeutic approaches. Thus, this study would provide novel insights for the early detection and risk stratification for the clinical management of ESCC and potentially improve the outcomes of ESCC.
Fine Structure Histopathology of Labyrinthitis Ossificans in the Gerbil Model

Labyrinthitis ossificans (LO) is the pathological deposition of new bone within the lumen of the cochlea and labyrinth. This process occurs most commonly as a result of infection or inflammation affecting the otic capsule. Trauma and vascular compromise can also lead to neo-ossification within the otic capsule. The mechanism that regulates this process remains unestablished. This study details the end-stage histopathology in high-resolution plastic thin sections. Twenty Mongolian gerbils were infected by intrathecal injection of Streptococcus pneumoniae type 3 followed by subcutaneous penicillin G procaine (8 days) and were painlessly sacrificed 3 months later. The cochleas were serially divided and sectioned for light and electron microscopy. Sixteen of 20 animals (27 of 40 cochleas) demonstrated LO. Cochlear damage was most extensive in the vestibule and basal turn and decreased toward the apex, which often appeared normal. The histopathologic findings consisted of 1) new bone, calcospherites, osteoid, and fibrosis without dense connective tissue or osteoblasts extending from the endosteal wall into the lumen of the vestibule and scala tympani; 2) areas of dense connective tissue and osteoid enclosed by epithelial cells conjoined with the organ of Corti, stria vascularis, spiral ligament, and vestibular (Reissner's) membrane; and 3) partial to complete loss of the organ of Corti, spiral ligament cell bodies, stria vascularis, and spiral ganglion cells. Osteoblastic activity was not demonstrated in end-stage ossification in LO in the gerbil model. Neoossification appears to occur by calcospherite deposition along collagen-like fibrils within osteoid. The destruction of the organ of Corti, spiral ganglion cells, stria vascularis, and cells of Reissner's membrane and the spiral ligament occurs even in the absence of ossification of the cochlear duct.
Reversed halo sign in active pulmonary tuberculosis: criteria for differentiation from cryptogenic organizing pneumonia.

OBJECTIVE The purpose of this study was to compare the morphologic characteristics of the "reversed halo" sign caused by tuberculosis with those caused by cryptogenic organizing pneumonia (COP) and to determine whether high-resolution CT (HRCT) can differentiate between these two conditions. MATERIALS AND METHODS We retrospectively reviewed the HRCT scans of patients with the reversed halo sign caused by active tuberculosis and HRCT scans of patients with the reversed halo sign caused by COP. The study included 12 patients with active pulmonary tuberculosis (10 women and two men) and 10 patients with biopsy-proven COP (five women and five men). Tuberculosis was diagnosed by culture of sputum, bronchoalveolar lavage, or biopsy specimen. All patients underwent HRCT, and the images were reviewed by two chest radiologists who reached decisions by consensus. RESULTS HRCT scans of all patients with active tuberculosis showed reversed halos with nodular walls; in most cases (10/12), we also observed nodules inside the halos. None of the HRCT scans of the COP cases reviewed had halos with nodular walls or nodules inside them. We also observed parenchymal abnormalities, such as consolidation, ground-glass, and linear opacities, associated with the reversed halo sign. Neither the number of reversed halo sign lesions nor the associated parenchymal lesions discriminated between tuberculosis and COP. Nevertheless, the association of the reversed halo sign with nodular walls or nodules inside the halo was seen only in tuberculosis patients. CONCLUSION Although COP is considered the most frequent cause of the reversed halo sign, the presence of nodular walls or nodules inside the reversed halo strongly favors a diagnosis of active pulmonary tuberculosis rather than COP.
Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue*

The MCP-1 (monocyte chemoattractant protein-1)/CCR2 (CC motif chemokine receptor-2) pathway may play a role in macrophage infiltration into obese adipose tissue. Here we investigated the role of CCR2 in the recruitment of bone marrow-derived macrophages into obese adipose tissue in vitro and in vivo. Using the TAXIScan device, which can measure quantitatively the directionality and velocity of cell migration at time lapse intervals in vitro, we demonstrated that bone marrow cells (BMCs) from wild type mice migrate directly toward MCP-1 or culture medium conditioned by adipose tissue explants of genetically obese ob/ob mice, which are efficiently suppressed by pharmacological blockade of CCR2 signaling. The number of F4/80-positive macrophages was reduced in the adipose tissue from high fat diet-fed obese KKAy or ob/ob mice treated with a CCR2 antagonist propagermanium relative to vehicle-treated groups. We also found that the number of macrophages is reduced in the adipose tissue from ob/ob mice reconstituted with CCR2-/- BMCs (ob/ob + CCR2-/- BMCs) relative to those with CCR2+/+ BMCs (ob/ob + CCR2+/+ BMCs). Expression of mRNAs for CD11c and TLR4 (Toll-like receptor 4) markers of proinflammatory M1 macrophages was also decreased in the adipose tissue from ob/ob + CCR2-/- BMCs relative to ob/ob + CCR2+/+ BMCs, whereas mannose receptor and CD163, markers of anti-inflammatory M2 macrophages, were unchanged. This study provides in vivo and in vitro evidence that CCR2 in bone marrow cells plays an important role in the recruitment of macrophages into obese adipose tissue.
A combined study of the equation of state of monazite-type lanthanum orthovanadate using in situ high-pressure diffraction and ab initio calculations.

Lanthanum orthovanadate (LaVO4) is the only stable monazite-type rare-earth orthovanadate. In the present paper the equation of state of LaVO4 is studied using in situ high-pressure powder diffraction at room temperature, and ab initio calculations within the framework of the density functional theory. The parameters of a second-order Birch-Murnaghan equation of state, i.e. those fitted to the experimental and theoretical data, are found to be in perfect agreement - in particular, the bulk moduli are almost identical, with values of 106 (1) and 105.8 (5) GPa, respectively. In agreement with recent reported experimental data, the compression is shown to be anisotropic. Its nature is comparable to that of some other monazite-type compounds. The softest compression direction is determined.
Optimized Parallel Architecture of Kalman Filter for Radar Tracking Applications

Kalman filter has been proven to be a very effective method to identify targets in an efficient and accurate manner. It provides efficient estimations when the precise nature of the modeled system is unknown in the presence of measurement and process noise. However, Kalman filter is computationally extensive especially in Multi Target Tracking (MTT) radar system. Therefore, it is desirable to apply it on advanced parallel architecture such as FPGA, GPU, and multi-cores to increase performance and achieve real time requirements. In this paper, we present an efficient parallel architecture of Kalman filter on different platforms such as FPGA, GPU, and multicore. Kalman filter operations are carried out on a single core CPU before they are decomposed, parallelized, scheduled, and mapped into FPGA and GPU platforms. Different optimization techniques for both the computation and memory utilization are adopted and applied to achieve high performance. The experimental results show the viability of using FPGA and GPU platforms to perform signal processing in real time. Parallel architectures can significantly outperform an equivalent sequential implementation due to their pipelined architecture, custom functionality of VLSI ASIC devices, flexibility, and adaptability. Our simulation results indicate that the achieved speed-up of FPGA and GPU over the sequential one is improved by up to 37.76 and 31.93, respectively. Keywords— Field-programmable gate array (FPGA), Graphic processing unit (GPU), Kalman filter, Optimization techniques, Parallel architecture.
Detection and quantification of Pratylenchus thornei in DNA extracted from soil using real-time PCR.

The root-lesion nematode Pratylenchus thornei is one of the most important pests restricting productivity of wheat in the Pacific Northwest (PNW). It is laborious and difficult to use microscopy to count and identify the nematodes in soils. A SYBR Green I-based real-time polymerase chain reaction (PCR) assay was developed to detect and quantify this species from DNA extracts of soil. A primer set, designed from the internal transcribed spacer region (ITS1) of rDNA, was highly specific to P. thornei and did not amplify DNA from 27 isolates of other Pratylenchus spp. , other nematodes, and six fungal species present in PNW wheat fields. A standard curve relating threshold cycle and log values of nematode number was generated from artificially infested soils. The standard curve was supported by a high correlation between the numbers of P. thornei added to soil and the numbers quantified using real-time PCR. Examination of 15 PNW dryland field soils and 20 greenhouse samples revealed significant positive correlations between the numbers determined by real-time PCR and by the Whitehead tray and microscopic method. Real-time PCR is a rapid, sensitive alternative to time-consuming nematode extractions, microscopic identification, and counting of P. thornei from field and greenhouse soils.
Dalbavancin: A New Option for the Treatment of Gram-Positive Infections

Objective: To review the pharmacology, microbiology, chemistry, in vitro susceptibility, pharmacokinetics, clinical efficacy, safety, tolerability, dosage, and administration of dalbavancin, a new semisynthetic lipoglycopeptide. Data Sources: A MEDLINE search, restricted to the English language, was conducted from 1966 through January 2006. Supplementary sources included program abstracts from the Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society of Microbiology, and the Infectious Diseases Society of America from 2000 to 2005 and information available from the manufacturer's Web site. Study Selection and Data Extraction: In vitro and preclinical studies, as well as Phase I, II, and III clinical trials, were evaluated to summarize the microbiology, pharmacology, clinical efficacy, and safety of dalbavancin. All published trials and abstracts citing dalbavancin were selected. Data Synthesis: Dalbavancin, a novel lipoglycopeptide, has a mechanism of action similar to that of other glycopeptides. It has in vitro activity against a variety of gram-positive organisms, but no activity against gram-negative or vancomycin-resistant enterococci that possess VanA gene. Due to its prolonged half-life (6–10 days), dalbavancin can be administered intravenously once weekly. In Phase II and III clinical trials, dalbavancin was effective and well tolerated for the treatment of skin and soft-tissue infections, catheter-related bloodstream infections, and skin and skin-structure infections. To date, adverse events are mild and limited; the most common include pyrexia, headache, nausea, oral candidiasis, diarrhea, and constipation. Conclusions: Dalbavancin appears to be a promising antimicrobial agent for the treatment of gram-positive infections. A new drug application was filed with the Food and Drug Administration (FDA) in December 2004. The FDA issued an approvable letter in 2005 for dalbavancin. If approved, dalbavancin is expected to be launched in the first quarter of 2006.
Communicating breast cancer risk information to young adult women: A pilot study

ABSTRACT Objective: To examine the effectiveness of a health promotion flyer to increase awareness of breast cancer risk and physical activity as a risk reduction strategy in young adult women. Methods: Young adult women (N = 123) viewed one of five health promotion flyers online and then completed measures of perceived breast cancer risk (PR) and perceived informativeness (PI) and a qualitative thought-listing activity. Results: Differences were observed in PI such that the control and low risk/low information messages were significantly less informative than the others. Qualitative analyses revealed two general themes: message content and flyer design. Additional analyses of the flyer design comments revealed four sub-themes: negative thoughts about the image, positive thoughts about the image, misunderstanding breast cancer risk information, and social comparison. Exploratory analyses controlling for message type indicated that image appraisal predicted PI such that those who commented on the image found the flyer to be less informative. Discussion: Results suggest that the flyer was informative but did not impact young women's breast cancer risk perceptions. Additionally, the image may have distracted young women from the intended message. Evaluating the acceptability of images used in health promotion materials is recommended before testing the effectiveness of the intervention.