Miracle-dz/UniFAR-FTUs huggingface dataset:
A 3-Years-Follow-Up Study of the Effect of the Weight Control Program on KAP and Behavior among Overweight and Obese School Children in Nonthaburi Province.

Objective To evaluate the outcome of a program on behavioral change to control weight on overweight and obese students at a primary school in 2013. The present study aimed to find whether the Knowledge Attitude Practice (KAP) and behavior on weight control from the behavioral change program were sustained. Material and Method This cross-sectional study was performed on overweight and obesity (OWOB) students in a primary school between June 2013 and July 2016. At the first visit in 2013, the affected students, parents, health education teachers, and food retailers were educated about the Behavior Change Program. They were then given 3-month interventions. Weight and height of the participants were recorded before and after interventions. The present study collected information on behaviors and factors associated with weight control of the affected students and parents at the two schools in July 2016 for comparison. Descriptive statistics, independent t-test, and Chi-square test were used for analysis. Results Review of the Behavior Change Program in 2013 showed that after three months-interventions 18% and 24% of 50 students had reduction and weight stability, respectively. The present study could follow 45 students. The comparison group consists of 50 students from another school who were matched by private-own type included capacity of the school, students of the same age group, and study classes. The analysis showed that three years after the program, the intervention group had more interest in weight control, and scored higher on food consumption behavior. Parents of the intervention group were older, had higher education, chronic illness, knowledge scores on food consumption and physical activities, and had higher parental attitude scores. Conclusion The behavior change program resulted in 42% weight control. The present study found that sustained behavior and significant factors were personal factor (interest to control weight), behavioral factor about food consumption, and parental factors of older age, more chronic illness, higher education, better knowledge on food consumption and physical activities, and better attitude.
Twisted Tales: Insights into Genome Diversity of Ciliates Using Single-Cell ‘Omics

Abstract The emergence of robust single-cell ‘omics techniques enables studies of uncultivable species, allowing for the (re)discovery of diverse genomic features. In this study, we combine single-cell genomics and transcriptomics to explore genome evolution in ciliates (a > 1 Gy old clade). Analysis of the data resulting from these single-cell ‘omics approaches show: 1) the description of the ciliates in the class Karyorelictea as “primitive” is inaccurate because their somatic macronuclei contain loci of varying copy number (i.e., they have been processed by genome rearrangements from the zygotic nucleus); 2) gene-sized somatic chromosomes exist in the class Litostomatea, consistent with Balbiani’s (1890) observation of giant chromosomes in this lineage; and 3) gene scrambling exists in the underexplored Postciliodesmatophora (the classes Heterotrichea and Karyorelictea, abbreviated here as the Po-clade), one of two major clades of ciliates. Together these data highlight the complex evolutionary patterns underlying germline genome architectures in ciliates and provide a basis for further exploration of principles of genome evolution in diverse microbial lineages.
Color vision deficiency among biomedical students: a cross-sectional study

Purpose To determine the prevalence of color vision deficiency (CVD) among first-cycle students of the Faculty of Medicine and Biomedical Sciences of the University of Yaoundé I. Patients and methods A cross-sectional descriptive study was carried out between October 1, 2015 and May 31, 2016. Distant visual acuity was measured and color vision test done for all consenting students. Ishihara’s plates were used to test all the participants. Those who failed the test were tested with the Roth’s 28 Hue test for confirmation of CVD and classification. Results A total of 303 students were included, among whom 155 were males (50.8%) and 148 were females (49.2%). The mean age was 20.2±2 years. Five students (1.6%) failed the Ishihara’s plate testing. Roth’s 28 Hue test confirmed CVD in 4 of those cases, giving a prevalence of 1.3%. There were equal numbers of protan and deutan CVD. Conclusion Despite its low prevalence among first-cycle students of the Faculty of Medicine and Biomedical Sciences, CVD screening should be performed in order to raise awareness, which will go a long way to help orientate the choice of future specialty.
Intermittent Running and Cognitive Performance after Ketone Ester Ingestion

Purpose Ingestion of exogenous ketones alters the metabolic response to exercise and may improve exercise performance, but it has not been explored in variable-intensity team sport activity, or for effects on cognitive function. Methods On two occasions in a double-blind, randomized crossover design, 11 male team sport athletes performed the Loughborough Intermittent Shuttle Test (part A, 5 × 15-min intermittent running; part B, shuttle run to exhaustion), with a cognitive test battery before and after. A 6.4% carbohydrate–electrolyte solution was consumed before and during exercise either alone (PLA) or with 750 mg·kg−1 of a ketone ester (KE) supplement. Heart rate, RPE, and 15-m sprint times were recorded throughout, and serial venous blood samples were assayed for plasma glucose, lactate, and &bgr;-hydroxybutyrate. Results KE resulted in plasma &bgr;-hydroxybutyrate concentrations of ~1.5 to 2.6 mM during exercise (P < 0.001). Plasma glucose and lactate concentrations were lower during KE compared with PLA (moderate-to-large effect sizes). Heart rate, RPE, and 15-m sprint times did not differ between trials. Run time to exhaustion was not different (P = 0.126, d = 0.45) between PLA (mean = 268 s, 95% confidence interval [CI] = 199–336 s) and KE (mean = 229 s, 95% CI = 178–280 s). Incorrect responses in a multitasking test increased from pre- to postexercise in PLA (mean = 1.8, 95% CI = −0.6 to 4.1) but not in KE (mean = 0.0, 95% CI = −1.8 to 1.8) (P = 0.017, d = 0.70). Conclusion Compared with carbohydrate alone, coingestion of a KE by team sport athletes attenuated the rise in plasma lactate concentrations but did not improve shuttle run time to exhaustion or 15-m sprint times during intermittent running. An attenuation of the decline in executive function after exhausting exercise suggests a cognitive benefit after KE ingestion.
Interactive Computing−Virtual Planning of Hip Joint Surgeries with Real-Time Structure Simulations

Current interactive computing state-of-the-art environments, libraries, and frameworks open the door for engineers to run their simulation codes in an interactive mode, i. e. allowing for estimations of the state and tendency, as well as modifications, during a simulation program runtime without the necessity for their own expertise in efficient algorithms and data structures, high-performance computing, and visualisation. Nevertheless, when it comes to the real-time response of the simulation to this interaction - namely, keeping the connection between the user's change and its effect intuitive or at least observable - these environments are still limited in their possible application and, furthermore, often entail heavy code changes in order to be coupled to existing codes. Therefore, we introduce an integration framework applicable to different engineering applications, which with only minor code modifications involved supports distributed simulations as well as visualisation on-the-fly and enables real time interactive computational steering. Furthermore, we present its integration into a previously existing pre-operative planning environment for joint replacement surgery, which makes possible an interactive patient-specific selection of the optimal implant design, size, and position. The environment is supposed to enable the real-time surgeon's interplay with virtual models of bones and implants in 3D, thus, simultaneous computation and visualisation of the load transfer between the bone and the implant. Moreover, we tackle the problem of long communication delays which occur in the case of rigid coupling of simulation back-ends with visualisation front-ends and handicap a surgeon in observing which of his modifications leads to which outcome.
Synthesis, Structural Analysis, and Biological Activities of Some Imidazolium Salts

Four newly synthesized imidazolium salts were characterized by nuclear magnetic resonance, vibrational spectra, and mass spectra. Then, the density functional theory calculations were performed to obtain the molecular configurations on which the theoretical nuclear magnetic resonance and infrared spectra were consequently obtained. The comparison of calculated spectra with the experimental spectra for each molecule leads to the conclusion that the theoretical results can be assumed to be a good approach to their molecular configurations. The in vitro biological activities of the salts on the selected bacteria and cancer cell lines were determined by using the broth dilution method according to Clinical and Laboratory Standards Institute guidelines. The 1,3-bis(2-hydroxyethyl) imidazolidinium bromide and 3-(2-ethoxy-2-oxoethly)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide showed efficiency on Bacillus cereus ATCC 11778. The 3-bis(2-carboxyethyl)-4-methyl-1-H-imidazol-3-ium bromide was effective on HeLa while a similar effect was observed on Hep G2 with 3-(2-carboxyethyl)-1-(3-aminopropyl)-1H-imidazol-3-ium bromide.
Pulse Wave Cycle Features Analysis of Different Blood Pressure Grades in the Elderly

Background and Objective The same range of blood pressure values may reflect different vascular functions, especially in the elderly. Therefore, a single blood pressure value may not comprehensively reveal cardiovascular function. This study focused on identifying pulse wave features in the elderly that can be used to show functional differences when blood pressure values are in the same range. Methods First, pulse data were preprocessed and pulse cycles were segmented. Second, time domain, higher-order statistics, and energy features of wavelet packet decomposition coefficients were extracted. Finally, useful pulse wave features were evaluated using a feature selection and classifier design. Results A total of 6,075 pulse wave cycles were grouped into 3 types according to different blood pressure levels and each group was divided into 2 categories according to a history of hypertension. The classification accuracy of feature selection in the 3 groups was 97.91%, 95.24%, and 92.28%, respectively. Conclusion Selected features could be appropriately used to analyze cardiovascular function in the elderly and can serve as the basis for research on a cardiovascular risk assessment model based on Traditional Chinese Medicine pulse diagnosis.
Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

CD8+ T cells recognizing antigenic peptides derived from conserved internal viral proteins confer broad protection against distinct influenza viruses. As memory CD8+ T cells change throughout the human lifetime and across tissue compartments, we investigated how T cell receptor (TCR) composition and diversity relate to memory CD8+ T cells across anatomical sites and immunological phases of human life. We used ex vivo peptide-HLA tetramer magnetic enrichment, single-cell multiplex RT-PCR for both the TCR-alpha (TCRα) and TCR-beta (TCRβ) chains, and new TCRdist and grouping of lymphocyte interactions by paratope hotspots (GLIPH) algorithms to compare TCRs directed against the most prominent human influenza epitope, HLA-A*02:01-M158–66 (A2+M158). We dissected memory TCR repertoires directed toward A2+M158 CD8+ T cells within human tissues and compared them to human peripheral blood of young and elderly adults. Furthermore, we compared these memory CD8+ T cell repertoires to A2+M158 CD8+ TCRs during acute influenza disease in patients hospitalized with avian A/H7N9 virus. Our study provides the first ex vivo comparative analysis of paired antigen-specific TCR-α/β clonotypes across different tissues and peripheral blood across different age groups. We show that human A2+M158 CD8+ T cells can be readily detected in human lungs, spleens, and lymph nodes, and that tissue A2+M158 TCRαβ repertoires reflect A2+M158 TCRαβ clonotypes derived from peripheral blood in healthy adults and influenza-infected patients. A2+M158 TCRαβ repertoires displayed distinct features only in elderly adults, with large private TCRαβ clonotypes replacing the prominent and public TRBV19/TRAV27 TCRs. Our study provides novel findings on influenza-specific TCRαβ repertoires within human tissues, raises the question of how we can prevent the loss of optimal TCRαβ signatures with aging, and provides important insights into the rational design of T cell-mediated vaccines and immunotherapies.
Techniques and Emerging Trends for State of the Art Equipment Maintenance Systems—A Bibliometric Analysis

The increasing interconnection of machines in industrial production on one hand, and the improved capabilities to store, retrieve, and analyze large amounts of data on the other, offer promising perspectives for maintaining production machines. Recently, predictive maintenance has gained increasing attention in the context of equipment maintenance systems. As opposed to other approaches, predictive maintenance relies on machine behavior models, which offer several advantages. In this highly interdisciplinary field, there is a lack of a literature review of relevant research fields and realization techniques. To obtain a comprehensive overview on the state of the art, large data sets of relevant literature need to be considered and, best case, be automatically partitioned into relevant research fields. A proper methodology to obtain such an overview is the bibliometric analysis method. In the presented work, we apply a bibliometric analysis to the field of equipment maintenance systems. To be more precise, we analyzed clusters of identified literature with the goal to obtain deeper insight into the related research fields. Moreover, cluster metrics reveal the importance of a single paper and an investigation of the temporal cluster development indicates the evolution of research topics. In this context, we introduce a new measure to compare results from different time periods in an appropriate way. In turn, among others, this simplifies the analysis of topics, with a vast amount of subtopics. Altogether, the obtained results particularly provide a comprehensive overview of established techniques and emerging trends for equipment maintenance systems.
A classroom intervention to improve executive functions in late primary school children: Too ‘old’ for improvements?

BACKGROUND Given the strong relationship between executive functions and academic achievement, there has been great interest in improving executive functions. School-based group interventions targeting executive functions revealed encouraging results in preschoolers and young school children; however, there is a paucity of studies in older primary school children (age 10-12). This is surprising considering that deficits in executive function performance can often be observed in this age group. AIMS Therefore, the aim of this study was to examine whether an innovative customized school-based group intervention could improve core executive functions (updating, inhibition, and shifting) in the age group concerned. SAMPLE In total, 118 ten- to twelve-year-old school children were recruited from eight participating classes. METHODS They were randomly assigned to one of two-six-week conditions of either a cognitive games group comprising of card and board games training executive functions (experimental group) or a wait-list control group (regular school lessons). In the cognitive games group, the class teachers held a 30-min training session twice a week. ANCOVAs (using pre-test values as covariate) were used to compare executive function performance between groups. RESULTS Results revealed that the cognitive games group improved specific executive functions (updating and shifting) compared to the control group. These findings indicate that a school-based group intervention can improve executive functions, even in 'older' primary school children. CONCLUSION This study provides empirical evidence for the effectiveness of a classroom-based cognitive training in older primary school children and is of practical relevance for educators.
Variant Serotypes of Fowl Adenovirus Isolated from Commercial Poultry Between 2007 and 2017 in Some Regions of China

SUMMARY The present study was performed to detect and characterize the serotypes of fowl adenovirus associated with inclusion body hepatitis (IBH) or hepatitis-hydropericardium syndrome (HHS) in commercial poultry in some regions of China between 2007 and 2017. Approximately 81 fowl adenovirus strains were isolated from liver or kidney samples from diseased poultry. A sequencing analysis of the hexon loop 1 gene revealed fowl adenovirus serotypes 8a, 8b, and 11 in samples of broilers with IBH, serotype 11 in layers with IBH, and serotype 4 in poultry with HHS. Of the fowl adenovirus serotype 4 strains, 62.07% were isolated from layers. Additionally, 74.07% of the isolated strains were fowl adenovirus serotype 11 prior to June 2014; 53.70% were serotype 4 after that time point; and strains isolated in the first half of 2017 were all serotype 8b, which was related to the widespread application of inactivated serotype 4 adenovirus vaccines. These results demonstrate that fowl adenovirus serotypes 11, 4, and 8b were the predominant serotypes in some regions of China between 2007 and June 2014, between June 2014 and 2016, and in the first half of 2017, respectively. Layers were the predominant host infected with fowl adenovirus serotype 4 and could also be infected by serotype 11.
Crowd Counting with Density Adaption Networks

Crowd counting is one of the core tasks in various surveillance applications. A practical system involves estimating accurate head counts in dynamic scenarios under different lightning, camera perspective and occlusion states. Previous approaches estimate head counts despite that they can vary dramatically in different density settings; the crowd is often unevenly distributed and the results are therefore unsatisfactory. In this paper, we propose a lightweight deep learning framework that can automatically estimate the crowd density level and adaptively choose between different counter networks that are explicitly trained for different density domains. Experiments on two recent crowd counting datasets, UCF_CC_50 and ShanghaiTech, show that the proposed mechanism achieves promising improvements over state-of-the-art methods. Moreover, runtime speed is 20 FPS on a single GPU.
Relationship between red cell distribution width and mean platelet volume with new onset atrial fibrillation afteroff-pump coronary artery bypass grafting.

OBJECTIVE The aim of this study was to evaluate the relationship between red blood cell distribution width (RDW) and mean platelet volume (MPV) with development of postoperative atrial fibrillation (PoAF) after off-pump coronary artery bypass grafting (CABG). BACKGROUND The RDW and MPV have been associated with some cardiovascular disorders. METHODS A total of 93 patients who underwent off-pump CABG were included in this study. The patients were divided into two groups as developing and nondeveloping PoAF groups in the postoperative period. We measured whether RDW and MPV levels are a predictive value for development PoAF. RESULTS There were 24 patients with PoAF enrolled (mean age: 66 ± 7.8 years) and 69 patients without PoAF (mean age: 56.26 ± 11.53 years). The PoAF was significantly correlated with age (p = 0.004), hematocrit (p: 0.010), RDW (p = 0.007) and creatinine (p = 0.006). Only advanced age (p = 0.012) was identified as an independent predictor of PoAF. For predicting PoAF, there was 79.2 % sensitivity and 65.2 % specificity for RDW (p = 0.001) and 62.5 % sensitivity and 55.1 % specificity for MPV (p = 0.062). CONCLUSIONS We found that RDW levels and MPV were not an independent predictor of the development of PoAF. However, elevated RDW levels and MPV may be one of the predictive values for PoAF development (Tab. 3, Fig. 2, Ref. 27).
A structural equation model of the family physicians attitude towards their role in prevention: a cross-sectional study in Switzerland

Abstract Background In contrast to many studies exploring barriers to preventive care in family medicine, there is less quantitative research regarding the self-perceived role of family physicians (FPs) in prevention and its predictive factors. Moreover, the existing studies considered this attitude as a homogeneous entity. The objective of this study is firstly, to characterize FPs’ attitudes towards prevention taking into account nine different prevention themes, and secondly, to explore the factors that could be predictive of this attitude. Methods The data stem from a cross-sectional national survey on prevention we conducted in Switzerland from 2015 to 2016 (170 physicians randomly drawn, online questionnaire). We first performed a confirmatory factor analysis to define a homogeneous latent variable regarding physicians’ attitude towards prevention, then, a structural equation modeling to identify potential predictors. Results The FP’ attitude towards their role in preventive care was homogeneously positive whatever the topic (smoking, drinking dietary habits, physical activities, and more generally, cardiovascular risk factors) except for occupational risks and cannabis consumption. A feeling of good effectiveness was a positive predictor of this positive attitude while seniority, the lack of reimbursement and being a physician from the German-speaking area were negative predictors. Conclusion The FP’ attitude about their role in prevention is homogeneous concerning the ‘classical’ topics of prevention, whereas they still under-recognize certain topics as important fields for prevention. To change this situation, we probably need a global effort to introduce other ways of thinking about prevention, including not only FP but also all stakeholders.
Cost-effectiveness analysis of subcutaneous immunoglobulin replacement therapy in Iranian patients with primary immunodeficiencies

Background: Economic evaluation of subcutaneous immunoglobulin therapy (SCIG) is important, and it has recently been used for treatment of patients with primary immunodeficiency (PID) diseases, and can improve allocation of resources in health care systems. The present research aimed at providing an economic assessment of SCIG and IVIG (intravenous immunoglobulin therapy) administration in Iran. Methods: Data related to clinical effectiveness were obtained from a meta-analysis. Economic analysis was performed taking into account the perspective of health care providers. Incremental cost-effectiveness ratio (ICER) was applied for economic evaluation of the 2 methods, and GDP per capita was considered as a threshold. Results: The results of meta-analysis suggested a higher effectiveness of SCIG compared to IVIG in serum immunoglobulin (Ig) levels (SMD= 0.336) and adverse effects (OR= 0.497), while the cost of IVIG was higher than SCIG ($1370 vs. $121). The ICER obtained in this paper ($2939 for adverse effects and $4348 for serum Ig level) was less than the GDP per capita in Iran ($4,916.10), and thus SCIG is a more cost-effective therapy for PID patients. Conclusion: Switching from IVIG to SCIG is cost-effective for PID patients and is approved by the health care providers’ points of view in this study.