Miracle-dz/UniFAR-FTUs huggingface dataset:
Four decades of leading‐edge research in the reproductive and developmental sciences: The Infant Primate Research Laboratory at the University of Washington National Primate Research Center

The Infant Primate Research Laboratory (IPRL) was established in 1970 at the University of Washington as a visionary project of Dr. Gene (Jim) P. Sackett. Supported by a collaboration between the Washington National Primate Research Center and the Center on Human Development and Disability, the IPRL operates under the principle that learning more about the causes of abnormal development in macaque monkeys will provide important insights into the origins and treatment of childhood neurodevelopmental disabilities. Over the past 40 years, a broad range of research projects have been conducted at the IPRL. Some have described the expression of normative behaviors in nursery‐reared macaques while others have focused on important biomedical themes in child health and development. This article details the unique scientific history of the IPRL and the contributions produced by research conducted in the laboratory. Past and present investigations have explored the topics of early rearing effects, low‐birth‐weight, prematurity, birth injury, epilepsy, prenatal neurotoxicant exposure, viral infection (pediatric HIV), diarrheal disease, vaccine safety, and assisted reproductive technologies. Data from these studies have helped advance our understanding of both risk and resiliency in primate development. New directions of research at the IPRL include the production of transgenic primate models using our embryonic stem cell‐based technology to better understand and treat heritable forms of human intellectual disabilities such as fragile X. Am. J. Primatol. 75:1063–1083, 2013. © 2013 Wiley Periodicals, Inc.
Evidence supporting a direct suppressive effect of growth hormone on serum IGFBP-1 levels. Experimental studies in normal, obese and GH-deficient adults.

It has occasionally been suggested that GH directly suppresses circulating IGFBP-1 levels, although it is generally believed that such an effect is secondary to a GH-induced increase in insulin levels. We present data from several experiments in which the effects of GH on IGFBP-1 could be studied more extensively. In normal subjects (n = 36), an i.v. GH bolus caused a small but significant decrease in plasma IGFBP-1 concentrations without changes in insulin [IGFBP-1 (microgram/l): 2.6 +/- 0.3 (GH) vs 3.2 +/- 0.4 (placebo), P < 0.05]. Conversely, a 28-h somatostatin infusion with and without GH administration during fasting in normal subjects yielded higher IGFBP-1 levels in the non-GH substituted study [50.5 +/- 5.3 (GH-suppression) vs 22.6 +/- 5.6 (GH-substitution), P < 0.01], comparable with an increased concentration of IGFBP-1 during fasting in GH-deficient patients without usual GH substitution [23.4 +/- 7.6 (GH pause) vs 14.1 +/- 4.9 (GH substitution), P < 0.01]. In both fasting studies insulin levels remained stable. During a hypocaloric diet, long-term GH treatment in obesity lead to a significant decline in IGFBP-1 level (2.3 +/- 0.6 vs 1.2 +/- 0.2, P < 0.01), while no changes were found in the placebo group. Again, insulin levels remained equally low in both studies. Finally, a significant rebound increase in IGFBP-1 level in response to insulin induced hypoglycemia was only observed among GH-deficient patients, but not in control subjects, the latter of whom responded to hypoglycemia with a significant increase in serum GH levels [23.2 +/- 7.2 (GHDA) vs 2.5 +/- 0.3 (controls), P < 0.01]. In conclusion, a suppressive effect of GH on IGFBP-1 appears to be unmasked in the presence of low or suppressed insulin levels, making GH a potential regulator of IGF-1 bioactivity in a hitherto unrecognized way.
A one year follow-up of illness management and recovery: participants' accounts of its impact and uniqueness.

BACKGROUND Illness Management and Recovery (IMR) is a standardized curriculum-based intervention to help people with serious mental illnesses acquire knowledge and skills to manage their illnesses effectively and achieve personal recovery goals. Recent evaluations of IMR have shown promising results with regard to feasibility and effectiveness. OBJECTIVES The aim of the present study was to investigate and describe (1) whether participants perceived IMR as effective a year after completion, (2) if so, in what domains did they experience the IMR program to be beneficial, and, (3) in what ways did the IMR program differ from prior rehabilitation interventions they had experienced. METHOD 36 people with serious mental illnesses completed the Narrative Evaluation of Intervention Interview (NEII), a year after completing IMR. Qualitative analysis of the interviews involved two judges independently identifying themes. Inter-rater reliability ranged from . 63 to 1.00. RESULTS Participants reported high levels of perceived helpfulness. Three domains of improvement attributed to IMR included cognition, coping, and social support. With regard to the uniqueness of the IMR intervention, five categories emerged: Learning new information, social support, coping and self management, program structure, and message of hope. CONCLUSIONS The positive impact of IMR reported in previous studies lasts as long as a year. Domains of reported improvement partially overlap with outcomes reported in previous studies. IMR is perceived to differ in several ways from other psychiatric rehabilitation interventions, both in technique as well as in message.
Civil Liability and the Response of Police Officers: The Effect of Lawsuits on Police Discretionary Actions

The purpose of this study was to determine if there is a relationship between police discretion in carrying out arrests and the fear of retaliation litigation. Quantitative methods were used to examine the concerns of 88 police officers and first-line supervisors regarding civil litigation and the impact these concerns have on the discharge of their duties. The results indicate that the police officers in the study were not significantly concerned with the deterrent effects of lawsuits on their arrest activity, but there was a difference between the opinions of the police officers and their superiors regarding civil liability. A significant finding was that almost half of the respondents indicated they possessed a bachelor’s degree, but over one third of the respondents indicated they had never received any formal training in civil liability. The study recommends strengthening the training curriculum in civil liability for all police academy attendees and through proper policy development and effective training programs through in-service activities for veteran police officers. In addition, employing risk managers in police agencies would allow for a systematic review of liability issues facing the agencies and the ability to mitigate those issues. Recommendation for future study would be to determine the current level of support for lawsuits by police officers and superiors, given the ever-changing environment in which policing occurs. Also recommended for future study would be to correlate between years on the job and how the concern of lawsuits changes respondents’ arrest decisions over time. Document Type Dissertation Degree Name Doctor of Education (EdD) Department Executive Leadership First Supervisor Josephine N. Moffett Subject Categories Education This dissertation is available at Fisher Digital Publications: https://fisherpub.sjfc. edu/education_etd/262 Civil Liability and the Response of Police Officers: The Effect of Lawsuits on Police Discretionary Actions
Incidence of Non-AIDS-Defining Malignancies in HIV-Infected Versus Noninfected Patients in the HAART Era: Impact of Immunosuppression

Background:The incidence of non-AIDS-defining malignancies (non-ADMs) is reported as unchanged or increasing in the highly active antiretroviral therapy era. Whether incidence of non-ADM is significantly higher in HIV-infected than in HIV-uninfected patients remains unclear. Methods:Incidence rates of malignancies were calculated in a cohort of veterans in care for HIV-infected and age, race, and gender-matched uninfected patients from 1997 to 2004. For HIV-infected patients, CD4 counts closest to first observation date were compared between those with and without cancer. Results:Thirty three thousand four hundred twenty HIV-infected and 66,840 HIV-uninfected patients were followed for a median of 5.1 and 6.4 years. The incidence rate ratio of HIV infected to HIV uninfected was 1.6 (1260 vs. 841 per 100,000 person-years; 95% confidence interval: 1.5 to 1.7). Incidence rate ratio for individual cancers was highest for anal cancer (14.9; confidence interval: 10.1 to 22.1). Among HIV-infected patients, median CD4 counts were lower for those with non-ADM (249 vs. 270, P = 0.02), anal cancer (156 vs. 270; P < 0.001), and Hodgkin lymphoma (217 vs. 269; P = 0.03). Prostate cancer was associated with a higher CD4 count (311 vs. 266; P < 0.001). Conclusions:In the highly active antiretroviral therapy era, the incidence of non-ADMs is higher among HIV-infected than HIV-uninfected patients, adjusting for age, race, and gender. Some non-ADMs do not seem to be associated with significantly lower CD4 counts.
Porcine Embryonic Brain Cell Cytotoxicity Mediated by Human Natural Killer Cells

Intracerebral transplantation of porcine embryonic dopamine-producing neurons has been suggested as a method to treat patients with Parkinson's disease. Even though the brain is an immunologically privileged site, neuronal xenografts are usually rejected within a few weeks. T cells are important for this process, but the exact cellular events leading to rejection are poorly characterized. Brain cells from ventral mesencephalon of 26–27-day-old pig embryos were used as target cells in flow cytometry-assessed cytotoxicity assays using non- and IL-2-activated CD3–CD16+CD56+ human natural killer (NK) cells as effector cells. The ability of human NK cells to kill pig embryonic brain cells by antibody-dependent cellular cytotoxicity (ADCC) in the presence of nondepleted and anti-Galα1,3Gal antibody-depleted human blood group AB serum (AB serum) was evaluated using the same assay. Both nondepleted and anti-Galα1,3Gal antibody-depleted AB serum could mediate ADCC of pig embryonic VM cells when human NK cells were used as effector cells. Nonactivated NK cells did not show any direct cytotoxic effect on freshly isolated VM cells, whereas IL-2-activated NK cells killed approximately 50% of the VM cells at an effector-to-target ratio of 50:1 in a 4-h cytotoxicity assay. Activation of VM cells by TNF-α did not change their sensitivity to human NK cell cytotoxicity. Human NK cells may thus contribute to a cellular rejection of pig neuronal xenografts by ADCC, or following IL-2 activation, by a direct cytotoxic effect.
Fatigue Self-Management Behaviors in Patients With Advanced Cancer: A Prospective Longitudinal Survey.

PURPOSE/OBJECTIVES To explore the fatigue self-management behaviors and factors associated with effectiveness of these behaviors in patients with advanced cancer. DESIGN Prospective longitudinal interviewer-administered survey. SETTING Royal Brisbane and Women's Hospital in Queensland, Australia. SAMPLE 152 outpatients with metastatic breast, lung, colorectal, and prostate cancer experiencing fatigue were recruited. METHODS Patients were surveyed on three occasions. MAIN RESEARCH VARIABLES Fatigue self-management behavior (perceived effectiveness, self-efficacy, and frequency), medical and demographic characteristics (sites of primary cancer and metastasis, comorbidity, performance status), social support, depression, anxiety, and other symptoms were assessed. FINDINGS The participants reported moderate levels of fatigue at baseline and maintained moderate levels at four and eight weeks. On average, participants consistently used about nine behaviors at each time point. Factors significantly associated with higher levels of perceived effectiveness of fatigue self-management behaviors were higher self-efficacy, higher education level, and lower levels of depressive symptoms. CONCLUSIONS The findings of this study demonstrate that patients with cancer, even those with advanced disease, still want and are able to use a number of behaviors to control their fatigue. Self-management interventions that aim to enhance self-efficacy and address any concurrent depressive symptoms have the potential to reduce fatigue severity. IMPLICATIONS FOR NURSING Nurses are well positioned to play a key role in supporting patients in their fatigue self-management.
Hybrid model for short-term forecasting of loads and load control responses

A hybrid model for short-term forecasting of aggregated thermal loads and their load control responses is studied in this paper using field test data. Inputs include temperature measurement and forecast, measured power and control signals. The hybrid model comprises 1) partly physically based forecasting of the responses of the controlled thermal loads and the non-controlled power, and 2) forecasting the residual using Support Vector Machine (SVM). Their summation gives the hourly interval power forecast. Here partly physically based means that the model structure models thermal dynamics of houses. The response forecasting needs as inputs the daily heating energy demand and controllable power range, which are forecast by partly physically based models. Weekly load pattern is used to forecast the non-controllable power. SVM forecasts the residual. Alternative configurations are compared. The response forecasting model improved the forecasting accuracy most and adding the SVM for the residual further improved the accuracy.
A first-pass cost analysis of propofol versus barbiturates for children undergoing magnetic resonance imaging.

Intravenous (IV) propofol was compared with IV thiopental/pentobarbital as a sedative for children undergoing magnetic resonance imaging (MRI) of the brain or spine. Fifty-eight outpatients (aged 11 mo to 6 1/2 yr, ASA grade I and II) were enrolled in the study and randomized to two groups. After IV cannulation, Group I received IV propofol (1-2 mg/kg), followed immediately by a propofol infusion (75-100 micrograms.kg-1.min-1). Group II received IV thiopental (1-3 mg/kg) followed by a pentobarbital bolus (2-3 mg/kg). Supplemental thiopental doses (1-2 mg/kg) were administrated to maintain adequate sedation. Discharge time and postanesthesia recovery scores were determined by an independent blinded observer. Time of recovery to full consciousness in Group I was significantly less than in Group II (19 +/- 7 min vs 35 +/- 20; P < 0.005). Time to discharge was also significantly less in Group I (24 +/- 6 min vs 40 +/- 11; P < 0.05). A preliminary cost analysis was applied to the clinical data obtained and to a theoretical model of a pediatric MRI center. Cost analysis of anesthesia services revealed added drug costs ($1600.76 per year for the propofol group) but significant savings of postanesthesia care unit (PACU) nursing time ($5086.67 per year). Outcomes such as patient morbidity and technical quality of the MRI scans did not differ significantly between the two groups. In conclusion, analysis of the clinical data suggests that propofol may be more suitable than barbiturates for children undergoing outpatient procedures despite its higher price.
Pregnancy Outcomes in HIV-Infected Women: Experience from a Tertiary Care Center in India

Background and Objectives: There is conflicting data on the effect of HIV infection as well as antiretroviral therapy (ART) on pregnancy outcome. The objectives of this study were to compare pregnancy outcomes in women with and without HIV infection, and to evaluate the effect of HAART on pregnancy in HIV-infected women. Methods: This is a prospective case record analysis of 212 HIV-infected women delivering between 2002 and 2015, in a tertiary health care center in India. The pregnancy outcome in HIV-infected women was compared to 238 HIV-uninfected controls. Women received ART for prevention of mother to child transmission as per protocol which varied during the period of study. Effect of use of ART on preterm birth (PTB) and intrauterine growth restriction (IUGR) was analyzed. Results: HIV-infected women were more likely to have PTB, IUGR, and anemia (9.4%, 9.9%, 5.2%) compared to uninfected women (7.6%, 5%, 3.8%), this did not reach statistical significance (P-value = >0.05). The incidence of PIH, diabetes mellitus and intrahepatic cholestasis of pregnancy was similar in both groups. Mean birth weight was significantly lower in neonates of HIV-infected women (2593.60±499g) than HIV-uninfected women (2919±459g) [P-value=0.001]. neonatal intensive care unit admissions were also significantly higher in infants born to HIV-infected women (P-value=0.002). HIV-infected women on ART had decreased incidence of PTB and IUGR. Conclusion and Global Health Implications: Good antenatal care and multidisciplinary team approach can optimize pregnancy outcomes in HIV-infected women.
Stress as a trigger for headaches: Relationship between exposure and sensitivity

Abstract This study investigated the relationship between length of exposure to a stressor and capacity of the stressor to elicit head pain. Some 127 participants, 93 of whom suffered from regular headaches, were randomly assigned to five experimental conditions, defined by length of exposure to a stressor. Participants attended a single laboratory session divided into three phases: pre-intervention test, intervention and post-intervention test. The main finding was a significant cubic trend between length of exposure to the stressor and ratings of head pain. This trend indicated that very short exposure to the stressor increased sensitivity, whilst longer exposure decreased sensitivity, but even longer exposure increased sensitivity. These results build on earlier studies that suggest the traditional clinical advice to headache sufferers, that the best way to prevent headaches is to avoid the triggers, runs the risk of establishing an insidious sensitization process, thereby increasing headache frequency.
Single channel properties of neuronal nicotinic ACh receptors in stratum radiatum interneurons of rat hippocampal slices

1 The single channel properties of neuronal nicotinic ACh receptors (nAChRs) were investigated in outside‐out patches from CA1 stratum radiatum interneurons from thin slices of rat hippocampus. 2 The application of ACh (10 μm to 1 mm) induced the opening of observable single channel currents with two distinct current levels, which corresponded to conductance levels of 38 ± 3 and 62 ± 2 pS. The 38 pS channel was observed in 10 % (n= 260) of patches, whereas the 62 pS channel was observed in 4 % of patches; these two channel types were most often observed independently. 3 The α7‐selective nAChR antagonist methyllycaconitine (MLA; 50 nm) reduced the open probability of the 38 pS channel by 73 %. In contrast, the 62 pS channel was unaffected by MLA, but instead was blocked by dihydro‐β‐erythroidine (DHβE; 10 μm), a broad spectrum nAChR antagonist. 4 These data suggest that rat hippocampal CA1 stratum radiatum interneurons in the slice possess at least two different types of functional nAChRs, an α7‐containing subtype with a single channel conductance of 38 pS, and a non‐α7 subtype with a single channel conductance of 62 pS.
Prevalence of temporomandibular joint dysfunction and its signs among the partially edentulous patients in a village of North Gujarat.

UNLABELLED There is disagreement about the association between missing teeth and the presence of temporomandibular disorder (TMD). AIM To investigate whether, the span of edentulousness, gender, number of quadrants involved, pathological migration and the type of kennedy's classification are related to the temporomandibular joint (TMJ) dysfunction signs. MATERIALS AND METHODS Clinical examination of 250 patients (males 99 and females 151) was done among the age group of 35 to 45 years. The patients were partially edentulous for 6 months or more and did not wear any kind of prosthesis. RESULTS Among 250 subjects, females showed more TMJ dysfunction signs. Clicking sounds were present in 46.5%, mandibular deviation was present in 40% of individuals, TMJ tenderness was observed in 32% and masseter was involved in 32% of individual. Temporomandibular joint dysfunction signs in relation to pathologic migration of teeth show that clicking and mandibular deviation was present in 54.5 and 49.2% and among muscles masseter muscle tenderness 41.9% was more commonly present. Masseter muscle tenderness 64.1% was seen in individuals who were edentulous for more than 5 years. CONCLUSION Females subjects had a significantly higher prevalence of TMJ dysfunction signs then male subjects. As the span and time of edentulousness, the number of missing teeth and the number of quadrant involved increased, the signs of dysfunction became more prevalent. Among the TMJ dysfunction signs deviation and clicking sound were most frequently observed. The masseter muscle was most commonly affected and demonstrated muscle tenderness.
A comparison of the Full Outline of UnResponsiveness (FOUR) score and Glasgow Coma Score (GCS) in predictive modelling in traumatic brain injury

Abstract Objectives: To compare the performance of multivariate predictive models incorporating either the Full Outline of UnResponsiveness (FOUR) score or Glasgow Coma Score (GCS) in order to test whether substituting GCS with the FOUR score in predictive models for outcome in patients after TBI is beneficial. Material and methods: A total of 162 TBI patients were prospectively enrolled in the study. Stepwise logistic regression analysis was conducted to compare the prediction of (1) in-ICU mortality and (2) unfavourable outcome at 3 months post-injury using as predictors either the FOUR score or GCS along with other factors that may affect patient outcome. The areas under the ROC curves (AUCs) were used to compare the discriminant ability and predictive power of the models. The internal validation was performed with bootstrap technique and expressed as accuracy rate (AcR). Results: The FOUR score, age, the CT Rotterdam score, systolic ABP and being placed on ventilator within day one (model 1: AUC: 0.906 ± 0.024; AcR: 80.3 ± 4.8%) performed equally well in predicting in-ICU mortality as the combination of GCS with the same set of predictors plus pupil reactivity (model 2: AUC: 0.913 ± 0.022; AcR: 81.1 ± 4.8%). The CT Rotterdam score, age and either the FOUR score (model 3) or GCS (model 4) equally well predicted unfavourable outcome at 3 months post-injury (AUC: 0.852 ± 0.037 vs. 0.866 ± 0.034; AcR: 72.3 ± 6.6% vs. 71.9%±6.6%, respectively). Adding the FOUR score or GCS at discharge from ICU to predictive models for unfavourable outcome increased significantly their performances (AUC: 0.895 ± 0.029, p = 0.05; AcR: 76.1 ± 6.5%; p < 0.004 when compared with model 3; and AUC: 0.918 ± 0.025, p < 0.05; AcR: 79.6 ± 7.2%, p < 0.009 when compared with model 4), but there was no benefit from substituting GCS with the FOUR score. Conclusion: Results showed that FOUR score and GCS perform equally well in multivariate predictive modelling in TBI.