Miracle-dz/UniFAR-FTUs huggingface dataset:
Neo-tAnGo: A neoadjuvant randomized phase III trial of epirubicin/cyclophosphamide and paclitaxel ± gemcitabine in the treatment of women with high-risk early breast cancer (EBC): First report of the primary endpoint, pathological complete response (pCR).

522 Background: Neo-tAnGo used a 2-by-2 factorial design, addressing: (i) gemcitabine (G) in a sequential neoadjuvant chemotherapy (CT) regimen of epirubicin/cyclophosphamide (EC) and paclitaxel (T); and (ii) the sequencing of these treatment components (EC then T ± G versus T ± G then EC). METHODS Patients (Pts) with early breast cancer (T2 tumours or above) were randomised to EC then T, T then EC, EC then TG or TG then EC. All components were given x 4 cycles. (E= 90 mg/m2 day (d)1 every (q) 21d; C = 600 mg/m2 d1 q21d; T = 175 mg/m2 d1 q14d; G = 2,000 mg/m2 d1 q14d. ) The primary endpoint was pCR, defined as absence of invasive disease in the breast and axillary lymph nodes. 800 pts were required to detect 10% differences in the primary endpoint pCR rates, at the 5% (2-sided) significance level with 85% power. Stratification was by age, inflammatory/locally advanced disease, tumour size, clinical involvement of axillary nodes and oestrogen receptor (ER) status. RESULTS Between January 2005 and September 2007, 831 pts were randomised by 88 consultants from 57 UK centres. Characteristics were balanced across groups: 63% <50 years old, 25% had inflammatory and/or locally advanced disease, 79% of tumours <50 mm, 50% node positive and 34% ER negative. Two-reader review of 813 (98%) eligible pts'. pathology reports, blinded to treatment arm, were carried out. pCR rates were 17% (95% CI 14-21) for EC&T pts and 17% (95% CI 14-21) for EC&TG pts (p = 0.98). However the sequence T±G then EC, showed pCR of 20% (95% CI 16-24) compared with 15% (95% CI 11-18) for EC then T±G pts (p = 0.03). Adjustment by stratification did not alter results. CONCLUSIONS The Neo-tAnGo results confirm those of the adjuvant tAnGo trial in terms of gemcitabine effect (ASCO 2008). The sequence of T±G-first has demonstrated a significant advantage in pCR compared with the more conventional anthracycline-first sequencing. [Table: see text].
Interpretative enactments and the analytic setting

Enactments are recognized to be inevitable, sometimes informative and yet harmful to the patient and to the analytic process (Sandler 1976, 1977; Joseph 1981, 2003). Supporting the argument that enactments can be useful, Sandler (1976) even suggests that the analyst should cultivate a free-fl oating responsiveness, as a counterpart to Freud’s free-fl oating attention, so that his reactions as well as his thoughts and feelings contribute to the understanding of his patients. He describes how an infantile role-relationship can be played out and examined as it is actualized in the relationship with the analyst (Sandler, 1976). Similarly, Joseph (1981, 1989) presents extensive work supporting her idea that the analyst is inevitably drawn into playing a role in the patient’s phantasy and that observing this role can shed light on the patient’s defensive system, and on his habitual style of object relationships. It is diffi cult to reconcile the idea that enactments can give helpful information about the patient and his relationships with the recognition that, in the process, boundaries may be violated and to a greater or lesser extent both the patient and the analytic work can be damaged. Enactments by defi nition cross the boundary from thought to action and, unless they are recognized and regulated, can enter that grey area between normal technique, technical error and unethical boundary violation (Gabbard and Lester, 1995). I believe they must be tolerated as part of the analyst’s ordinary fallibility, but monitored as a check on our self-understanding and our contact with reality.
A Radiostereometric Analysis of the Movements of the Sacroiliac Joints in the Reciprocal Straddle Position

Study Design. A Radiostereometric analysis of the reciprocal straddle position. Objectives. To evaluate the magnitude of rotation in the sacroiliac joints in the reciprocal straddle position. Summary of Background Data. The reciprocal straddle position has been objectified in different studies, using different techniques, to show a sacroiliac motion between 5° and 36°. Previous studies with radiostereometric analysis during different provocations reported much smaller movements. Methods. Six women with posterior pelvic pain of long duration after pregnancy (n = 5) and sacroiliitis (n = 1) underwent radiostereometric analysis in the sustained reciprocal straddle position. Results. A reciprocal movement could be demonstrated in the sacroiliac joints in the reciprocal straddle position. However, the movements were 10 times smaller than reported in earlier studies of the reciprocal straddle position. Conclusions. It was possible to demonstrate reciprocal movements of the sacroiliac joints in the straddle position. However, the radiostereometric analysis technique showed the movements to be small, as reported in other mobility studies.
MENINGITIS AND SPLENIC INFARCTION DUE TO DISSEMINATED MYCOBACTERIUM GENAVENSE INFECTION IN AN HIV PATIENT CASE REPORT AND REVIEW OF THE LITERATURE

Abstract We report a case of disseminated infection with Mycobacterium genavense in a 58 year old HIV positive woman presenting with fever, diarrhea, abdominal pain and weight loss. She had a striking hepatosplenomegaly, abdominal lymphadenopathy, anaemia and thrombopenia. Direct smears and cultures of blood, stool, sputum, urine and bone marrow were negative for common and opportunistic microorganisms. Splenectomy revealed numerous acid fast bacill. Lumbar puncture also showed acid fast bacilli at direct examination. Specific PCR and 16s rRNA gene sequencing identified M. genavense. The outcome was fatal despite antimycobacterial therapy. M. genavense must be included in the differential diagnosis of fever, weight loss, lymphadenopathy and splenomegaly in immunocompromised patients. Prompt diagnosis is based on molecular biology methods. Empirical therapy, using at least three antimycobacterial agents, including clarithromycin should be introduced in case of high clinical suspicion.
A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases.

From kinetic data (k, T) we calculated the thermodynamic parameters for various processes (nucleation, elongation, fibrillization, etc.) of proteinaceous diseases that are related to the β-amyloid protein (Alzheimer's), to tau protein (Alzheimer's, Pick's), to α-synuclein (Parkinson's), prion, amylin (type II diabetes), and to α-crystallin (cataract). Our calculations led to ΔG≠ values that vary in the range 92.8-127 kJ mol-1 at 310 K. A value of ∼10-30 kJ mol-1 is the activation energy for the diffusion of reactants, depending on the reaction and the medium. The energy needed for the excitation of O2 from the ground to the first excited state (1Δg, singlet oxygen) is equal to 92 kJ mol-1 So, the ΔG≠ is equal to the energy needed for the excitation of ground state oxygen to the singlet oxygen (1Δg first excited) state. The similarity of the ΔG≠ values is an indication that a common mechanism in the above disorders may be taking place. We attribute this common mechanism to the (same) role of the oxidative stress and specifically of singlet oxygen, (1Δg), to the above-mentioned processes: excitation of ground state oxygen to the singlet oxygen, 1Δg, state (92 kJ mol-1), and reaction of the empty π* orbital with high electron density regions of biomolecules (∼10-30 kJ mol-1 for their diffusion). The ΔG≠ for cases of heat-induced cell killing (cancer) lie also in the above range at 310 K. The present paper is a review and meta-analysis of literature data referring to neurodegenerative and other disorders.
Quantitative and qualitative insights into consumers’ sustainable purchasing behaviour: a segmentation approach based on motives and heuristic cues

ABSTRACT The present study draws on the concepts of motives and heuristics to thoroughly understand consumers’ sustainable consumption behaviour in the context of personal care products. The mixed-methods approach combines real purchasing data with in-depth qualitative data to generate insights with a high external validity. In the first section of the study, quantitative analysis is applied to actual purchasing behaviour (n = 10,772,477) to identify market trends. Three main groupings, along with specific heuristic cues, are established. In the second step, a qualitative study (n = 21) provides deeper insights into consumers’ motives and decision-making processes. By synthesising the quantitative and qualitative research findings, a segmentation approach is developed. Relevant motives and values, and corresponding specific heuristic cues are identified for each consumer segment. Analysis suggests that consumers are motivated by self-interest and environmental motives, and that they use simple heuristic cues to make quick and satisfying purchasing decisions. Both retailers and manufacturers can leverage these insights to seize the opportunities of the developing market for sustainable personal care products.
Evaluating sustainable supply chain indicators using fuzzy AHP: Case of Indian automotive industry

Purpose Sustainability in supply chain is gaining attention in recent years due to environmental concern, enforced legislation, green issues, social responsibility, etc. Sustainable supply chain (SSC) has revolved around the various dimensions including economy, environment and societal factors since its inception. The purpose of this paper is to identify, prioritize and evaluate the indicators of SSC so that organizations can cultivate strategies to implement them on priority. Design/methodology/approach This paper proposes a methodology based on fuzzy analytic hierarchy process to prioritize the indicators of SSC. A numerical analysis of Indian automotive industry is presented to demonstrate the use of the proposed method. This proposed method considered fuzzy framework that can handle impreciseness and uncertainty. Sensitivity analysis is also performed to test the robustness of the proposed model. Findings Potential indicators are identified from relevant literature and validated by industry experts. This research finalizes the SSC indicators under three dimensions so that prioritization of identified indicators can be developed and the insights relationship of factors would be explored. The results of the study found that environmental and social dimensions of sustainability contribute more toward the sustainability. Research limitations/implications This study is limited to identify evaluation factors and other factors have not been identified and categorized. Evaluation is done by experts in this area so it is natural that views of decision makers may be subjective and vary with regard to industry type, priorities, resources, etc. Practical implications This study will help industry to identify, evaluate and prioritize factors for successful implementation of sustainability in their supply chain. Automotive companies could device these factors by applying the outcome of the study in their operations with higher priority to integrate sustainability in their supply chain. Originality/value These factors are identified to implement sustain ability into supply chain practices for automotive industry.
Associations between different forms of gastro-oesophageal reflux disease

Abstract Aims—To study the epidemiology and natural history of gastro-oesophageal reflux disease (GORD). Methods—Retrospective cohort study involving all 172 hospitals of the Department of Veterans Affairs. A total of 194 527 patients with GORD were followed between 1981 and 1994. Distribution of oesophagitis, oesophageal ulcer, oesophageal stricture, strictured hiatus hernia, hiatus hernia, and pyrosis by age, sex, and ethnicity were determined. The comorbid occurrence of various forms of GORD in identical patients was analysed by an age and race standardised morbidity ratio. The population of all hospitalised veterans was used for comparison. Results—Severe forms of GORD associated with oesophageal erosions, ulcers, or strictures, affected elderly, white, male patients more often than their corresponding opposite demographic group. All forms of GORD clustered in the same patient population; on average, any form of GORD was 10 times more likely to occur in a patient with another form of GORD than without. The highest morbidity ratio (22) was found in oesophageal ulcer and stricture. About one third of all patients with oesophageal erosions, ulcers, or strictures also had hiatus hernia; 46% of patients with hiatus hernia were diagnosed as having other forms of GORD. While one third of all oesophageal strictures appeared in patients without other forms of GORD diagnosed at any time, oesophageal ulcers were always associated with some other form of GORD. No clear cut progression in different forms of GORD was found. Conclusions—Older age, male sex, and white ethnicity are risk factors in the development of severe forms of GORD. The most severe grade of GORD is reached at the onset of the disease.
The role of Brazilian firms in nanotechnology development

Brazil is the leading country in nanotechnology research in Latin America and has been the first to implement a national policy to stimulate the productive sector to innovate in that emerging field. Based on Georgia Tech global databases of nanotechnology scientific publications and patents, we analyze the role of Brazilian firms in the development of nanotechnology, their research and commercialization activities, their collaborations, and their engagement with nanotechnology programs. We look in particular at nine case studies of leading firms. Our data show that the nanotechnology policy has stimulated research in companies in close collaboration with universities and research centers. However, most of those companies were already within a very select group of innovative firms or are very dynamic starts-ups. Overall, companies still exhibit a low innovation profile in nanotechnology, in line with the overall poor industry innovation landscape of the country.
Consumer Acceptance of Self-service Technologies: An Ability–Willingness Model

This study suggests that, in addition to willingness, ability is a relevant and important dimension of self-service technology (SST) acceptance and, going beyond prior studies' exclusive focus on willingness, develops an SST acceptance model that captures both consumer ability and willingness to use such technologies. Previous research on consumer acceptance of SSTs has focused primarily on consumers' willingness, while neglecting their ability – this is evident in many SST studies investigating adoption intentions. However, using an SST often requires skills and some level of confidence. Drawing upon the ability–willingness framework, this study adopts a cross-sectional field survey approach to recruit real consumers using self-checkout technology at a supermarket. Results from structural equation modelling based on 281 consumers highlight the relevance and importance of ability, and show that consumers' willingness and ability to use SSTs are determined by different factors.
Effect of work intensity on performance in a psychomotor task during exercise.

The influence of work intensity on performance in a psychomotor task was examined using 10 male subjects. The experiment involved a 60s pursuit rotor task during both the 4th and 6th min of cycling at zero resistance and at 25,40,55,70 and 85% V˙O2 max. A curve of the inverted-U form was found to fit the performance data significantly (p<0·05). The mean optimal loading was calculated to occur at a moderate work intensity of 38% V˙O2 max. The results have implications for activities where psychomotor tasks are superimposed on a requirement for high muscular power output levels.
Consumers' Perceived Quality, Perceived Value and Perceived Risk Towards Purchase Decision on Automobile

Problem statement: As the level of competition keep on increasing in Malaysia automobile market, it is essential for every automobile producer companies to understand customer insight in order to further increase their share of wallet. Thus, they need to understand what factors might influence their customers’ decision in purchasing an automobile. Therefore, the objectives of this research is to study the relationships of perceived quality, perceived value and perceived risk that will affect on Malaysia consumer purchase decision towards cars. Approach: Survey using convenience sampling was done at Klang Valley to customers’ age between 23-65 years old and above. Questionnaires were distributed to 200 respondents at the sampling location. Results: All the 200 sets of data were reliable where Cronbach’s alpha is more than 0.6. Pearson correlation also showed the strength of the relationship between those variables and normality assumption was meet. Results from multiple regression analysis showed the positive association between the three factors mentioned previously with purchase decision. Conclusion/Recommendations: The results from this research provide a platform for Malaysia automobile makers to understand consumer behavior and how it affects their purchase decision. In order to ensure that the findings of sample are representative and conclusive, future research should be include with larger number of respondents.
Economics of Voluntary Information Sharing

We show that lenders join a U.S. commercial credit bureau when information asymmetries between incumbents and entrants create an adverse selection problem that hinders market entry. Lenders also delay joining when information asymmetries protect them from competition in existing markets, consistent with lenders trading off new market entry against heightened competition. We exploit shocks to information coverage to show that lenders enter new markets after joining the bureau in a pattern consistent with this trade-off. Our results illuminate why intermediaries voluntarily share information and show how financial technology that mitigates information asymmetries can shape the boundaries of lending.
The Impact of Reputation Management on Hotel Image among Internal Customers: The Case of Egyptian Hotels

This study aims to identify the success factors of hotel reputation and how these factors affecting the hotel image among internal customers of five-star hotels in Egypt based on the RepTrak (reputationinstitute.com) model. A structured questionnaire was developed to test hypotheses using a sample of 340 customers, with a response rate of 68 per cent. The study has tested seven hypotheses of how the success factors (products and services, innovation of the services, society, leadership, environment, performance, and governance) affect the outcome variable (image of the hotel within internal customers). Regression was used to measure the relationships among the variables of the study. The findings of this study have shown significant relationships among the variables under investigation. The findings indicate the factors negatively affecting the image of the hotel reputation need to be addressed seriously particularly in relation to the workplace environment. This factor represents one main target of the hotel reputation management. Previous research focused exclusively on hotel environmental reporting of large chains. Adopting an exploratory approach, this study analyses the hotel reputation and how this affecting the hotel image, as well as their impact on the perceptions of internal customers at five-star hotels in Egypt. Hotel reputation appears to emerge as a critical dimension of benchmarking of a hotel performance.
Financial Reporting and Trade Credit: Evidence from Mandatory IFRS Adoption

We investigate the effect of mandatory IFRS adoption on trade credit, which is informal financing based largely on private information and supplier-customer dependencies. We document that firms in countries that adopt IFRS receive more trade credit from their suppliers, consistent with better financial reporting playing a role in facilitating informal financing. This increase is larger in countries with a low level of societal trust, a poor pre-IFRS-adoption information environment, and stronger legal enforcement. These cross-sectional results suggest that a reduction in information risk is one channel through which IFRS adoption increases trade credit. This increase is also larger for firms with greater exposure to foreign markets, and this finding highlights the importance of more comparable international financial reporting standards in facilitating cross-country trade credit. We also find a stronger positive effect of IFRS adoption on trade credit for firms with operations that typically need liquidity from suppliers. Finally, we find that firms in countries that adopt IFRS also extend more trade credit to their customers. Overall, our results support the notion that financial reporting can have a causal effect on trade credit.
JOB SATISFACTION, EMOTION REGULATION, STRESS RELATIONS AND AGING

This study aimed to investigate the relationship between emotion regulation, perceived global stress and job satisfaction by taking into account the changes due to aging. Survey method was used to collect data on measures of job satisfaction, emotion regulation, and stress. Two emotion regulation strategies, reappraisal (regulation of cognition) and suppression (regulation of the behavior) were considered. Data were analyzed by using structural equation modeling, and conventional statistical analysis. Findings show that emotion regulation is associated with decreased stress and increased job satisfaction, and stressors in life do not need to be workrelated to decrease job satisfaction. Managerial style, job control, and job insecurity also highly influence job satisfaction. Emotion regulation increases in older age, and emotion regulation is associated with job satisfaction only in older, but not in younger adults.
Influence of differentiation strategy on performance of hotels: the moderating role of environmental munificence

This study investigates whether environmental munificence directly and indirectly predicts the relationship between differentiation strategy and performance.A total of 83 managers from hotels in Kano state were participated.A questionnaire was administered to collect information on socio demographics and on differentiation strategy, environmental munificence, and performance. Results revealed that differentiation strategy, environmental munificence was positively associated with performance. Environmental munificence fully moderates the relationships of differentiation strategy and performance.This article, apart from its contribution to the business strategy research, has meaningful implications for managers and policy-makers, the future research directions are discussed.
Dasar-Dasar Manajemen Keuangan

Dasar-dasar Manajemen Keuangan DAFTAR ISI KATA PENGANTAR v DAFTAR ISI vii BAGIAN 1 1 PENDAHULUAN DAN KONSEP-KONSEP DASAR BAB 1. FUNGSI DAN TUJUAN MANAJEMEN KEUANGAN 3 1.1. Keuangan Itu Menarik 3 1.2. Fungsi Manajemen Keuangan 4 1.3. Tujuan Manajemen Keuangan 6- 1.4. Keuangan Perusahaan (Corporate Finance) 7 1.5. Keuangan Perusahaan dan Agency Theory 10 1.6. Perkembangan Manajemen Keuangan 12 1.7. Pendekatan yang Dipergunakan 13 1.8. Ringkasan 14 Konsep-konsep Penting dalam Bab ini 15 Pertanyaan dan Soal 15 BAB 2. PASAR FINANSIAL DAN PERUSAHAAN 17 2.1. Pengantar 17 2.2. Mengapa Pasar Finansial Terbentuk 17 2.3. Lembaga-lembaga Keuangan 19 2.4. Alokasi Dana Lewat Tingkat Keuntungan 23 2.5. Ringkasan 26 Konsep-konsep Penting dalam Bab ini 28 Pertanyaan dan Soal 28 BAB 3. NILAI WAKTU UANG 29 3.1. Nilai Masa yang Akan Datang dan Nilai Sekarang 29 3.2. Internal Rate of Return atau Yield 33 3.3. Ringkasan 35 Konsep-konsep Penting dalam Bab ini 37 Pertanyaan dan Soal 37 BAB 4. DASAR-DASAR PENILAIAN 39 4.1. Konsep Penilaian Umum 39 4.2. Penilaian Sekuritas Berpenghasilan Tetap 41 4.3. Penilaian Sekuritas tidak Berpenghasilan Tetap 42 4.4. Menentukan Tingkat Keuntungan yang Disyaratkan 45 4.5. Penggunaan CAPM untuk Menaksir Harga Saham 51 4.6. Ringkasan 52