Miracle-dz/UniFAR-FTUs huggingface dataset:
The silent epidemic of male suicide

Suicide in men has been described as a "silent epidemic": epidemic because of its high inci- dence and substantial contribution to men's mortality, and silent be - cause of a lack of public awareness, a paucity of explanatory research, and the reluctance of men to seek help for suicide-related concerns. A statistical overview demonstrates a shockingly high rate of death by sui- cide for men compared with women, and a need to focus attention on pre- vention, screening, treatment, and service delivery. Promising lines of research include identification of clinical indicators specifically pre- dictive of male suicide and explo- ration of precipitating and predis- posing factors that distinguish male suicide and account for the sub- stantial gender disparity. Only by breaking the silence—building pub- lic awareness, refining explanato- ry frameworks, implementing pre- ventive strategies, and undertaking research—will we overcome this epidemic.
Uterine Artery Embolization (UAE) for Fibroid Treatment – Results of the 7th Radiological Gynecological Expert Meeting

Uterine artery embolization (UAE) is a safe and effective organ sparing treatment for fibroid-related symptoms based on a broad range of published evidence including randomized-controlled trials. Indication for treatment by means of UAE are symptomatic uterine fibroids. UAE is an alternative to surgical and medical treatment for uterine fibroids as well as treatment by MRgFUS. This consensus paper covers the structural prerequisites, the criteria for technical and clinical success, contraindications, side effects and complications as well as the role of UAE treatment in women wishing to conceive and gives guidance on radiation safety measures and clinical follow-up.
The effects of different mode of melatonin administration on the development of high-calorie diet-induced obesity in rats

Currently, opportunities for the melatonin use in the obesity treatment are being studied because of his action on the: normalization of adipocyte secretion, the reduction of the pro-inflammatory state in adipose tissue, the stimulation of the beige adipocytes appearance, modulation of the eating behavior via influence on hypothalamic signals, and thermoregulation through affecting on brown adipocyte function, however, the mode, pathways and dose levels of the administration require detailed research. The aim of our study was to determine the influence of melatonin different time and mode treatment on body weight changes of diet-induced (high-calorie diet, HCD) obesity in rats. Melatonin was administered daily by gavage for 7 weeks in dose 30 mg/kg either 1 h after lights-on (ZT01) or 1 h before lights-off (ZT11) or continuously with drinking water (HCD water). Parameters, including weight gain, weight gain rate, body mass index, Lee index, related visceral fat weight, relative daily food and water consumption, were measured. Melatonin use significantly reduce weight gain rate in HCD ZT11 and HCD water group in 2 and 2,5 times; Lee index – by 6,6 % and 7,3 %; related visceral fat mass – by 38,5 %, respectively in compare with HCD. Animals without HCD which obtain melatonin did not change observed parameters, accept relative visceral fat mass (it was decreased in rely to control). The effects of different modes melatonin administration manifested in decrease weight gain rate, Lee index and relative visceral fat mass in rats with diet-induced obesity only after evening administration, as well as after delivery continuously with drinking water without any effect on food and water consumption.
Randomized phase 2 study of maintenance pemetrexed (Pem) versus observation (Obs) for patients (pts) with malignant pleural mesothelioma (MPM) without progression after first-line chemotherapy: Cancer and Leukemia Group B (CALGB) 30901 (Alliance).

8517 Background: Standard front-line chemotherapy for advanced MPM is (Pem and a platinum; optimal treatment duration is unknown. We performed a randomized phase 2 trial (NCT01085630) to determine if continuation of single-agent Pem after 4-6 cycles of Pem-platinum would improve progression-free survival (PFS). Methods: Eligible pts had histologically confirmed unresectable MPM, and performance status (PS) 0-1. Pts with at least stable disease following 4-6 cycles of Pem-platinum were stratified by first-line regimen (cis- or carboplatin) and histology (epithelioid versus other) and randomized 1:1 to Obs or continuation of Pem until progression. The primary endpoint was PFS. We assumed that Obs produced a median (m) PFS of 3 months (mo) and Pem would yield a 100% improvement in mPFS to 6 mo; 60 eligible pts (30 per arm) were to be randomized. Results: 72 pts from 30 sites registered 12/10-6/16. The study closed early due to slow accrual once 53 pts were randomized; 49 eligible pts (22 Obs, 27 Pem) are included in the efficacy analysis. Pt characteristics (Obs/Pem): age: median (range) 70 (39-85)/70 (52-87); male 68%/78%; PS 0 27%/33%; epithelioid histology 77%/70%; first-line cisplatin 27%/26%. A median of 4 cycles of Pem (range 1-33) was delivered; 22% of pts required dose modification. mPFS was 3 mo on Obs and 3.4 mo on Pem (hazard ratio (HR) 0.99; 95% CI: 0.51-1.90; p=0.9733). Median overall survival (mOS) was 11.8 mo for Obs, and 16.3 mo for Pem (HR 0.86; 95% CI 0.44-1.71; p=0.6737). Toxicities ≥ grade 3 on Pem included anemia 8%, lymphopenia 8%, neutropenia 4%, and fatigue 4%; there were no grade 5 toxicities. A higher baseline level of serum mesothelin related peptide (SMRP) was associated with worse PFS (HR 1.861, p=0.049). Baseline osteopontin did not significantly affect PFS (p=0.3630). Conclusions: Although it was well tolerated, maintenance Pem following initial Pem/platinum doublet chemotherapy does not improve PFS in MPM patients. High baseline SMRP was associated with shorter PFS. Support: U10CA180821, U10CA180882; https://acknowledgments.alliancefound. org . Clinical trial information: NCT01085630.
A phase II study of pembrolizumab for HPV-associated papilloma patients with laryngeal, tracheal, and/or pulmonary involvement.

2502 Background: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 & 11. RRP proliferates in the respiratory tract impacting breathing, swallowing, and voice and carries a 1-4% risk of malignant transformation. There is no curative therapy for RRP. Given the tolerized host immune response against HPV, in part through upregulation of the PD1:PDL1 axis, the safety and efficacy of pembrolizumab (pembro) as a novel treatment for this benign tumor patient (pt) population was evaluated in a phase II clinical trial. Methods: RRP pts > 12 years of age were treated with pembro 200mg every 3 weeks. Adjuvant surgical debridement of RRP was permitted for airway obstruction but not dysphonia. Primary endpoints were best overall response (ORR) (measured by endoscopic lesional burden) and safety. Greater than 5 pts with disease in response out of 21 (assuming > 1 of first n = 11 with disease in response) provided 86% power to distinguish between a 15% and a 38% ORR (one-sided 8% binomial test). Serial biopsies (up to 8 biopsies/patient over the 24 months of treatment) to identify biomarkers of response and mechanisms of immune resistance (PD-L1 expression, mutations in HLA class I antigen presentation machinery, and tumor mutational burden) are underway. Results: Accrual is complete (n = 21 pts accrued between May 2016 and Jan 2019). Median age (range) was 45 (19-68), 57% (12/21) were male and 67% (14/21) were white. As of February 1, 2019, ORR is 43% (9/21) (.95 two-stage CI: 22%-66%) (4 of 11 with juvenile-onset RRP and 5 of 10 with adult-onset RRP disease responded). No complete responses have been observed. Fatigue was the most frequent treatment related adverse event (TRAEs); Grade 3 TRAEs included uveitis and hypophysitis, both were reversible upon pembro discontinuation. The frequency of surgical interventions was reduced in all pts undergoing surgery for airway palliation prior to study entry. Conclusions: Pembro reduces the need for routine surgical interventions based on the response rates being achieved. Further study of pembro +/- other agents is warranted to achieve and sustain complete responses in this population. Clinical trial information: NCT02632344.
Trance And Transformation Of The Actor In Japanese Noh And Balinese Masked Dance-drama

List of Illustrations Foreword Preface (Professor John Emigh, Brown University) Acknowledgements Orientation The Mask: Art Object, Pedagogical Tool or Transformational Mechanism? Masks and Balinese Culture Japanese Mask Tradition and Noh Drama Balinese Masks in Practice Noh Masks in Performance The Consciousness of the Masked Actor The Mask and Transformation Glossary 1 Balinese Terms Glossary 2 Japanese Terms Works Consulted Index
Attentional limitations in dual-task performance.

People's ability (or inability) to do different activities or tasks at the same time is a topic of much interest not only to psychologists, but also to the proverbial "person in the street". It is natural to wonder about what we as human beings can and cannot do. An understanding of our limitations should also have practical value, because the intelligent design of human/machine systems depends as much on knowing the capabilities of people as it does on knowing the capabilities of machines. Human performance limits have played an important role in catastrophes that have occurred in aviation and other fields; a better understanding of those limits might help in designing systems and procedures that can minimize the frequency of such disasters. Simultaneous performance of different tasks is intellectually intriguing as well. The limitations on simultaneous cognition may provide important clues to the architecture of the human mind. The notion that dual-task performance limitations have implications about the "unity of the mind" occurred to people long before the present era of information-processing psychology. In the late nineteenth century, for example, the educated public was fascinated with a phenomenon called "automatic writing", in which People were claimed to be able to write prose while carrying out other tasks (see Koutstaal, 1992). This chapter provides an overview of research on attentional limitations dual-task performance. The organization of the chapter follows a plan
A phylogenetic approach to a global supraspecific taxonomy of Cortinarius (Agaricales) with an emphasis on the southern mycota

A section-based taxonomy of Cortinarius, covering large parts of the temperate North and South Hemispheres, is presented. Thirty-seven previously described sections are reviewed, while another forty-two sections are proposed as new or as new combinations. Twenty additional clades are recovered but not formally described. Furthermore, six new or combined species names are introduced, and one species is neotypified. The structure is supported by morphological characters and molecular evidence, based on two (nrITS and nrLSU) and four (nrITS, nrLSU, rpb1 and rpb2) loci datasets and analysed by Maximum Likelihood methods (PhyML, RAxML). Altogether 789 Cortinarius samples were included in the study.
Perioperative (P) UGT1A1 genotype guided irinotecan (iri) dosing ‘gFOLFIRINOX’ for gastroesophageal adenocarcinoma (GEA).

4050 Background: Complete resection (R0) and pathologic response grade (PRG) correlate with long-term GEA outcome. FOLFIRINOX demonstrated efficacy in advanced GEA; gFOLFIRINOX improved tolerability. We evaluated R0, PRG and tolerability in this pilot P study. Methods: Gastric body (GB) + esophagogastric (EGJ) GEA patients (pts) with ≥T3Nx or TxN+ were enrolled & treated with 4 pre + 4 postoperative biweekly cycles of gFOLFIRINOX (5-FU 2400mg/m2 over 46 hrs; oxaliplatin 85mg/m2; iri: 180mg/m2 for UGT1A1 genotype 6/6, 135mg/m2 for 6/7, 90mg/m2 for 7/7) (+ trastuzumab (T) 6mg/kg then 4mg/kg for HER2+) with prophylactic peg-filgastrim. 1°endpoint R0 resection required 36 pts to assess for a 90% R0 rate (intention to treat (ITT)) with 90% power + 0.05 alpha; ≥30/36 R0 considered positive. Co-1°endpoint was PRG (Becker); 36 pts provided 85% power with 0.05 alpha for a complete (pCR G1a) rate of 16%. 2°endpoints were safety/toxicity, PET response, & R0/PRG by tumor site, histologic subtype, HER2 status, & UGT1A1 genotype. We report efficacy and toxicity data from the neoadjuvant (Neo) portion of the study; postop data & survival outcomes will be presented at the meeting. Results: 4 sites enrolled 36 ITT pts between 2/2014-8/2018; 75% male, median age 66 (range 27-85). All pts completed all 4 cycles of Neo therapy: 10% had any dose reduction of iri (16%/0%/25% by genotype 6/6, 6/7, 7/7); any G3+ toxicity occurred in 35% of pts (32% 6/6, 29% 6/7, 75% 7/7). G3+ toxicity in ≥5% of pts: diarrhea (17.5%; 6/6 21%, 6/7 11%, 7/7 25%), anemia (5%), vomiting (5%). Efficacy is shown in the Table. Of pts going to surgery, both R1 resections were GB linitus. PRG1(a+b) was achieved in 36% of ITT pts, 46% of intestinal type histology. Conclusions: Neo gFOLFIRINOX was tolerable with surrogate efficacy comparable to FLOT. Clinical trial information: NCT02366819. [Table: see text]
The prevalence of risk factors for foot ulceration in Egyptian diabetic patients

The effect of ethnicity on diabetic foot ulceration (DFU), neuropathy and peripheral arterial disease (PAD) remains controversial, with few previous studies from Egypt. The aim of this study was to examine the prevalence of DFU and its risk factors in a cohort of patients presented to the outpatient diabetes clinic at Mansoura University Specialized Medical Hospital. Over a period of 12 months, 1220 diabetic patients were screened for DFU, neuropathy, PAD, foot deformities, and skin and nail abnormalities. The mean age was 50.5 ± 10.9 years and 36.8% were male. Diabetes duration was 7.9 ± 5.9 years and BMI 34.5 ± 6.7. The prevalence of active or past foot ulceration was 1.2% and 5.7% respectively. Monofilament insensitivity was found in 124 patients (10.2%). Only 38 patients (3.1%) had absent foot pulses. We found dry skin in 544 patients (44.6%), calluses in 69 (5.7%), tinea pedis in 532 (43.6%) and thick nails in 215 (17.6%); 61.6% of our patients used inappropriate footwear and 93.8% received no prior foot education. It was concluded that, despite the low prevalence of neuropathy and PAD in our diabetic patients, the prevalence of DFU is still high. The lack of knowledge regarding diabetic foot problems, inappropriate footwear and the high prevalence of skin and nail pathology in Egypt could explain this paradox. It is suggested that regional differences in the risk factors for DFU should be considered when preventative strategies are planned. Copyright © 2008 John Wiley & Sons.
A Case of Human Immunodeficiency Virus-triggered Hemophagocytic Lymphohistocytosis Presenting with Severe Bleeding Tendency

Human immunodeficiency virus (HIV) is one of the less common triggers of secondary hemophagocytic lymphohistiocytosis (HLH) in which coagulation disorder is a frequent manifestation. Here, we present a case of HIV-triggered secondary HLH presenting with severe bleeding tendency and fever. Despite high-dose dexamethasone infusion (10 mg/body surface area/day), progressive disseminated intravascular coagulation and thrombocytopenia resulted in massive hemathochezia: the bleeding episode ceased after endoscopic hemoclipping. After then, he took a highly-active antiretroviral therapy (HAART). Eventually, body temperature and overall laboratory findings normalized in response to HAART. Clinicians should not overlook HIV infection as a possible trigger of secondary HLH. In such cases, HAART is the core treatment.
Boys' love manga : essays on the sexual ambiguity and cross-cultural fandom of the genre

"Boys' love," a male-male homoerotic genre written primarily by women for women, enjoys global popularity and is one of the most rapidly growing publishing niches in the United States. It is found in manga, anime, novels, movies, electronic games, and fan-created fiction, artwork, and video. This collection of 14 essays addresses boys' love as it has been received and modified by fans outside Japan as a commodity, controversy, and culture.
The Prognostic Role of Klotho in Patients with Chronic Kidney Disease: A Systematic Review and Meta-analysis

Objective The prognostic role of Klotho in patients with chronic kidney disease is still controversial. Therefore, we performed this meta-analysis to assess the relationship between the low sKlotho level and the risk of adverse kidney outcomes. Materials and Methods We systematically searched medical databases, such as PubMed, Embase, and the Cochrane Library, for eligible publications regarding the relationship between the low sKlotho level and risk of adverse kidney outcomes. The quality of included studies was assessed by using the Newcastle–Ottawa Scale. Combined hazard ratios (HRs) and its 95% confidence intervals (CIs) were calculated using a random- or fixed-effect model. Subgroup analysis was conducted with stratification by age, estimated glomerular filtration rate (eGFR), follow-up interval, region, and study quality. All data was analyzed by RevMan 5.3 analysis software. Results Eight cohort studies with 3586 participants from 3818 studies were included in our final analysis. Levels of sKlotho were significantly correlated with the eGFR, with a summary correlation coefficient r and 95% CI of 0.469 (0.226, 0.658). Additionally, low sKlotho levels were strongly associated with increased adverse kidney outcomes, and the pooled HR and its 95% CI were 1.64 (1.19, 2.26; P = 0.002), despite publication bias and statistical heterogeneity (I 2 = 52%, P = 0.07). Furthermore, this positive correlation was still observed in all of the subgroup analyses. However, heterogeneity was present in subgroup analyses stratified by the eGFR and follow-up interval. Conclusion Levels of sKlotho are positively correlated with the eGFR, and low sKlotho levels are significantly associated with an increased risk of poor kidney outcomes. Therefore, sKlotho could be used as a novel biomarker for early diagnosis and prognostic assessment for patients with chronic kidney disease. Studies with a larger sample size and longer follow-up period are warranted to validate our results.
A History of Psychiatry: From the Era of the Asylum to the Age of Prozac

Freud's wish for control and Jung's pugna cious ambition precipitated their final break. In his personal relationships Jung emerges badly. His long marriage survived only because of his wife's forbearance; his notorious womanising with colleagues, pu pils and patients is now well known. His wife was induced to accept a mmnage a trois with one mistress, Toni Wolff. Jung was a charismatic, difficult personality with a â€ ̃¿ mediumistic' intuition, who attracted both men and women throughout his life. As McLynn aptly shows, he clashed with men and kept few male friends, but was always surrounded by loyal female disciples. McLynn is also fair in his treatment of the question of Jung's anti-Semitism and his ambiguous dealings with the Nazis. This biography is informative and com prehensive in its coverage of Jung's personal and public life. However, it emphasises his significance today as guru of New Age interest in Eastern thought, the paranormal and astrology, rather than recognising his place in the contemporary psychoanalytic and psychotherapeutic world.
Depth-resolved ultra-high field fMRI reveals feedback contributions to surface motion perception

Human visual surface perception has neural correlates in early visual cortex, but the extent to which feedback contributes to this activity is not well known. Feedback projections preferentially enter superficial and deep anatomical layers, while avoiding the middle layer, which provides a hypothesis for the cortical depth distribution of fMRI activity related to feedback in early visual cortex. Here, we presented human participants uniform surfaces on a dark, textured background. The grey surface in the left hemifield was either perceived as static or moving based on a manipulation in the right hemifield. Physically, the surface was identical in the left visual hemifield, so any difference in percept likely was related to feedback. Using ultra-high field fMRI, we report the first evidence for a depth distribution of activation in line with feedback during the (illusory) perception of surface motion. Our results fit with a signal re-entering in superficial depths of V1, followed by a feedforward sweep of the re-entered information through V2 and V3, as suggested by activity centred in the middle-depth levels of the latter areas. This positive modulation of the BOLD signal due to illusory surface motion was on top of a strong negative BOLD response in the cortical representation of the surface stimuli, which depended on the presence of texture in the background. Hence, the magnitude and sign of the BOLD response to the surface strongly depended on background properties, and was additionally modulated by the presence or absence of illusory motion perception in a manner compatible with feedback. In summary, the present study demonstrates the potential of depth resolved fMRI in tackling biomechanical questions on perception that so far were only within reach of invasive animal experimentation.
Germination of Medusahead in Response to Osmotic Stress

Requirements for germination and rate of juvenile root and shoot elongation of 23 medusahead (Taeniatherum asperum (Sim.) Nevski) selections were investigated in relation to osmotic stress. These were compared with the germination and elongation characteristics of other grasses. Aqueous solutions of different osmotic pressures were obtained by dissolving polyethylene glycol in water. Successive 4-bar increases in osmotic pressure markedly reduced medusahead germination until germination terminated at 16 bars. Other grass species exhibited higher germination than medusahead under osmotic stress. Medusahead juvenile root and shoot elongation under low and moderate osmotic pressure exceeded all other species tested.
Complete mitochondrial genome of South American sea lion Otaria byronia (Carnivora: Otariidae)

Abstract The complete mitochondrial genome of Otaria byronia was sequenced for the first time. The mitogenome is 16,640 bp long and encodes 13 protein-coding genes (PCGs), 22 tRNA genes, two rRNA genes, one origin of light strand replication (OL), and a control region (CR). The overall base composition is 33.1%, 27.0%, 14.2%, and 25.7% for A, C, G, and T, respectively. The CR with 1186 bp is in the position between tRNA-Phe and tRNA-Pro genes. Phylogenetic analyses show the classification status of the pinniped species and reveal that O. byronia is grouped to the Family Otariidae.