Miracle-dz/UniFAR-FTUs huggingface dataset:
Metabolic Cardiovascular Syndrome and Risk of Dementia in Japanese-American Elderly Men: The Honolulu-Asia Aging Study

Cardiovascular risk factors often cluster into a metabolic syndrome that may increase the risk of dementia. The objective of the present study was to assess the long-term association between clustered metabolic cardiovascular risk factors measured at middle age and the risk of dementia in old age. This prospective cohort study of cardiovascular disease was started in 1965 and was extended to a study of dementia in 1991. The subjects were Japanese-American men with an average age of 52.7±4.7 (mean±SD) years at baseline. Dementia was diagnosed in 215 men, according to international criteria, and was based on a clinical examination, neuropsychological testing, and an informant interview. The z scores were calculated for 7 risk factors (random postload glucose, diastolic and systolic blood pressures, body mass index, subscapular skinfold thickness, random triglycerides, and total cholesterol). The relative risk (RR [95% CI]) of dementia (subtypes) per 1 SD increase in the sum of the z scores was assessed after adjustment for age, education, occupation, alcohol consumption, cigarette smoking, and years of childhood lived in Japan. The z-score sum was higher in demented subjects than in nondemented subjects, indicating a higher risk factor burden (0.74 versus −0.06, respectively;P =0.008). Per SD increase in the z-score sum, the risk of dementia was increased by 5% (RR 1.05, 95% CI 1.02 to 1.09). The z-score sum was specifically associated with vascular dementia (RR 1.11, 95% CI 1.05 to 1.18) but not with Alzheimer’s disease (RR 1.00, 95% CI 0.94 to 1.05). Clustering of metabolic cardiovascular risk factors increases the risk of dementia (mainly, dementia of vascular origin).
Detection of added respiratory loads in patients with restrictive lung disease.

In patients with airways obstruction, inspiratory resistive load detection conforms to Weber's law: the higher the background or intrinsic pulmonary resistance, the greater the threshold resistance (the resistance detected 50% of the time, delta R50). In patients with restrictive lung disease, the pulmonary elastance is increased, and the present study was undertaken to assess whether Weber's law applies to elastic load detection in these patients. In 7 patients with restrictive lung disease caused by interstitial fibrosis, there was a significantly decreased total lung capacity compared with that in 6 normal subjects (mean, 63.1 and 101% predicted, respectively; p less than 0.01) and significantly increased total pulmonary elastance (means +/- SD, 14.4 +/- 4.7 and 9.6 +/- 1.8 cmH2O/L, respectively; p less than 0.05). There was no significant difference (p greater than 0.1) between the 2 groups in delta R50; however, the elastic load detection threshold, delta E50, was significantly greater (p less than 0.05) in the patients than in the normal subjects (mean +/- SD, 2.8 +/- 1.3 and 1.4 +/- 0.4 cmH2O/L, respectively). When the detection threshold was adjusted for the background elastance, however, there was no significant difference between the 2 groups (mean +/- SD, 0.21 +/- 0.1 and 0.15 +/- 0.04, respectively; p greater than 0.05). These results confirm that Weber's law is also applicable to the detection of added elastic loads in patients with restrictive lung disease. (ABSTRACT TRUNCATED AT 250 WORDS)
Costs and utilization of hemophilia A and B patients with and without inhibitors

Abstract Objective: To evaluate the health system costs among patients with hemophilia A and B with and without inhibitors over 5 years. Methods: This was a retrospective, observational study utilizing medical and pharmacy electronic medical records and administrative encounters/claims data tracking US patients between 2006–2011. Patients with diagnosis codes for hemophilia A and B were identified. Patients with inhibitors were characterized by utilization of bypassing agents activated prothrombin complex concentrate or factor VIIa on two or more distinct dates. Severity was classified as mild, moderate, or severe based on laboratory tests of clotting factor. Results: There were 160 hemophilia A patients and 54 hemophilia B patients identified. From this group, seven were designated as patients with inhibitors (five with hemophilia A and two with hemophilia B). Hemophilia A patients without inhibitors reported 65 (41.9%) as being severe, 19 (12.3%) as moderate, and 71 (45.8%) as mild. Hemophilia B patients without inhibitors reported nine (17.3%) had severe, 13 (25.0%) had moderate, and 30 (57.7%) had mild hemophilia. All patients with inhibitors had been hospitalized in the previous 5 years compared to 64 (41.3%) with hemophilia A without inhibitors and 22 (42.3%) with hemophilia B without inhibitors. The median aggregate cost per year (including factor and health resource use) was $325,780 for patients with inhibitors compared to $98,334 for hemophilia A patients without inhibitors and $23,265 for hemophilia B patients without inhibitors. Conclusions: The results suggest that, while the frequency of inhibitors within the hemophilia cohort was low, there was a higher frequency of hospitalizations, and the associated median aggregate costs per year were 3-fold higher than those patients without inhibitors. In contrast, hemophilia B patients experience less severe disease and account for lower aggregate yearly costs compared to either patients with hemophilia A or patients with inhibitors.
Characterization of lipopolysaccharides from Escherichia coli K-12 mutants

Chemical analyses of the carbohydrate composition of lipopolysaccharides (LPS) from a number of LPS mutants were used to propose a schematic composition for the LPS from Escherichia coli K-12. The formula contains four regions: the first consists of lipid A, ketodeoxyoctonoic acid, and a phosphorous component; the second contains only heptose; the third only glucose; and the fourth additional glucose, galactose, and rhamnose. LPS from E. coli B may have a similar composition but lacks the galactose and rhamnose units. A set of LPS-specific bacteriophages were used for comparing three mutants of Salmonella with a number of LPS mutants of E. coli K-12. The results confirm that there are basic similarities in the first and second regions of the LPS structure; they also support the four region divisions of the LPS formula. Paper chromatography was used for characterization of 32-P-labeled LPS from different strains of E. coli and Salmonella. The Rf values for LPS varied from 0.27 to 0.75 depending on the amounts of carbohydrates in the molecule. LPS from all strains studied was homogenous except for strain D31 which produced two types of LPS. Mild acid hydrolysis of labeled LPS liberated lipid A and two other components with phosphate, one of which was assigned to the first region. It is suggested that paper chromatography can be used in biosynthetic studies concerning regions 2 to 4.
The Effect of International Work Experience on the Career Success of Expatriates: A Comparison of Assigned and Self‐Initiated Expatriates

This article is one of the first to examine the long-term effect of expatriation on careers, comparing the impact of international work experience on the career success of assigned and self-initiated expatriates. Our sample consists of employees who were working abroad in 2004, and we examine their subjective and objective career success eight years later. Despite the “dark side of international careers” arguments associated with the repatriation literature, we find that the long-term impacts of international work experience on career success are generally positive and mainly unrelated to whether the work experience was acquired as an assigned or self-initiated expatriate. Companies recruit employees with international experience externally but are much more likely to offer further internal jobs to assigned expatriates. This reinforces the need for further research and for companies to see all those with international experience as important elements of the workforce. © 2017 Wiley Periodicals, Inc.
Valuation Efficiency of Secondary Markets for Formerly Illiquid Assets: The Case of German KG Ship Funds

Until the outbreak of the most recent shipping crisis in late 2008, German KG ship funds had been a prominent vehicle for investing in, and financing of, global shipping operations. Given that KG shares are not designed to be traded, investors are expected to require higher returns as compensation for illiquidity. Since the early 2000s, secondary market platforms for trading of shares in ship funds emerged. If investors could sell their shares at prices reflecting the fundamentals of their asset, lower returns would be demand. Making use of a novel methodological approach, 341 transactions of container ship funds executed from 2007 through 2012 are analyzed. The results reveal a surprisingly high fundamental-valuation efficiency: The identified pricing-relevant variables explain about 86% of the variations in the secondary market valuations of the ship funds. However, it is documented that shares in ship funds trade at discount relative to fundamental asset values.
Fez1/lzts1 alterations in gastric carcinoma.

PURPOSE Loss of heterozygosity (LOH) involving the short arm of chromosome 8 (8p) is a common feature of the malignant progression of human tumors, including gastric cancer. We have cloned and mapped a candidate tumor suppressor gene, FEZ1/LZTS1, to 8p22. Here we have analyzed whether FEZ1/LZTS1 alterations play a role in the development and progression of gastric carcinoma. EXPERIMENTAL DESIGN We examined Fez1/Lzts1 expression in 8 gastric carcinoma cell lines by Western blot, and in 88 primary gastric carcinomas by immunohistochemistry. Twenty-six of these 88 primary gastric carcinomas were also microdissected and tested for LOH at the FEZ1/LZTS1 locus and for mutation of the FEZ1/LZTS1 gene. Furthermore, we studied the FEZ1/LZTS1 gene regulation and transcriptional control and the methylation status of the 5' region of the gene in all 8 gastric carcinoma cell lines. RESULTS Fez1/Lzts1 protein was barely detectable in all of the gastric cancer cell lines tested and was absent or significantly reduced in 39 of the 88 (44.3%) gastric carcinomas analyzed by immunohistochemistry, with a significant correlation (P < 0.001) to diffuse histotype. DNA allelotyping analysis showed allelic loss in 3 of 17 (18%) and microsatellite instability in 4 of 17 (23.5%) cases informative for D8S261 at the FEZ1/LZTS1 locus. When we compared the presence of LOH with Fez1/Lzts1 expression, we found loss of protein expression in all three of the tumors with allelic imbalance at D8S261. A missense mutation was detected in one case that did not express Fez1/Lzts1. Hypermethylation of the CpG island flanking the Fez1/Lzts1 promoter was evident in six of the eight cell lines examined as well as in the normal control. CONCLUSIONS Our findings support FEZ1/LZTS1 as a candidate tumor suppressor gene at 8p in a subtype of gastric cancer and suggest that its inactivation is attributable to several factors including genomic deletion and methylation.
Co-amoxiclav in recurrent acute otitis media: placebo controlled study.

OBJECTIVE--To determine the efficacy of coamoxiclav in children aged 6 months to 12 years with recurrent acute otitis media. DESIGN--A randomised double blind placebo controlled clinical trial. SETTING--General practice in the Netherlands. PATIENTS--121 children with recurrent acute otitis media, defined by onset of otalgia and otoscopic signs of middle ear infection within four to 52 weeks after the previous attack. Confirmation of diagnosis and randomisation was done by otolaryngologists. INTERVENTION--Oral co-amoxiclav or placebo in weight related doses for seven days. MAIN OUTCOME MEASURE--An irregular clinical course defined as the presence of otalgia or a body temperature greater than or equal to 38 degrees C, or both, after three days. RESULTS--Eleven (16%; 95% confidence interval 9% to 28%) children had an irregular course in the co-amoxiclav group and 10 (19%; 9% to 31%) in the placebo group (difference not significant). Age, dichotomised at 2 years, was the only significant prognostic factor for irregular course of the disease (odds ratio 5.9; 1.8 to 19.1). Among children aged below 2 years, 28% (4/14) in the co-amoxiclav group and 58% (7/12) in the placebo group had irregular courses. For children 2 years and older these percentages were 13% (7/52) and 7% (3/41). CONCLUSION--Children with recurrent acute otitis media are at greater risk of an irregular clinical course of the disease than children with a first episode of acute otitis media. Co-amoxiclav has no significant benefit over placebo in treating children over 2 years with acute otitis media.
Randomized controlled trial of full and brief cognitive-behaviour therapy and wait-list for paediatric obsessive-compulsive disorder.

BACKGROUND Reviews and practice guidelines for paediatric obsessive-compulsive disorder (OCD) recommend cognitive-behaviour therapy (CBT) as the psychological treatment of choice, but note that it has not been sufficiently evaluated for children and adolescents and that more randomized controlled trials are needed. The aim of this trial was to evaluate effectiveness and optimal delivery of CBT, emphasizing cognitive interventions. METHODS A total of 96 children and adolescents with OCD were randomly allocated to the three conditions each of approximately 12 weeks duration: full CBT (average therapist contact: 12 sessions) and brief CBT (average contact: 5 sessions, with use of therapist-guided workbooks), and wait-list/delayed treatment. The primary outcome measure was the child version of the semi-structured interviewer-based Yale-Brown Obsessive Compulsive Scale. CLINICAL TRIAL REGISTRATION http://www.controlled-trials.com/ISRCTN/; unique identifier: ISRCTN29092580. RESULTS There was statistically significant symptomatic improvement in both treatment groups compared with the wait-list group, with no significant differences in outcomes between the two treatment groups. Controlled treatment effect sizes in intention-to-treat analyses were 2.2 for full CBT and 1.6 for brief CBT. Improvements were maintained at follow-up an average of 14 weeks later. CONCLUSIONS The findings demonstrate the benefits of CBT emphasizing cognitive interventions for children and adolescents with OCD and suggest that relatively lower therapist intensity delivery with use of therapist-guided workbooks is an efficient mode of delivery.
Fire disturbance and climate change: implications for Russian forests

Change in the Russian boreal forest has the capacity to alter global carbon and climate dynamics. Fire disturbance is an integral determinant of the forest’s composition and structure, and changing climate conditions are expected to create more frequent and severe fires. Using the individual tree-based forest gap model UVAFME, along with an updated fire disturbance module that tracks mortality based on tree-species and –size level effects, biomass and species dynamics are simulated across Russia for multiple scenarios: with and without fire, and with and without altered climate. Historical fire return intervals and percent of forest stand mortality are calculated for the Russian eco-regions and applied to 31 010 simulation points across Russia. Simulation results from the scenarios are compared to assess changes in biomass, composition, and stand structure after 600 years of successional change following bare-ground initiation. Simulations that include fire disturbance show an increase in biomass across the region compared to equivalent simulations without fire. Fire disturbance allows the deciduous needle-leaved conifer larch to maintain dominance across much of the region due to their high growth rate and fire tolerance relative to other species. Larch remain dominant under the scenario of altered climate conditions with fire disturbance. The distribution of age cohorts shifts for the scenario of altered climate with fire disturbance, displaying a bimodal distribution with a peak of 280-year-old trees and another of 100-year-old cohorts. In these simulations, fire disturbance acts to increase the turnover rate and patterns of biomass accumulation, though species and tree size are also important factors in determining mortality and competitive success. These results reinforce the importance of the inclusion of complex competition at the species level in evaluating forest response to fire and climate.
The review of “green” research in hospitality, 2000-2014

Purpose Green practices have been of increasing interest to both practitioners and researchers in the hospitality context. To understand how green practices have been adopted in the industry, a systematic review of recent hospitality literature is essential. The purpose of this paper is to identify research domains and formulate a definition of green practices that accurately reflects the current hospitality context. Design/methodology/approach The authors reviewed 146 articles on green practices published between 2000 and 2014 in eight hospitality journals. Using content analysis, multiple researchers coded the articles using a standardized coding scheme. Findings The number of articles on green practices in the hospitality context has been growing. Most studies focus on managers and the lodging sector. The authors identify three research domains for green practices in the hospitality literature: organizational, operational and strategic. They define a green practice as a value-added business strategy that benefits hospitality operations that engage in environmental protection initiatives. Research limitations/implications This framework may help practitioners develop green practice strategies and governments develop effective green policies and reinforce activities aimed at environmental protection. It provides theoretical foundation for future research related to green practices in the hospitality industry. Overall, hospitality stakeholders can use this framework to understand the implementation and effects of green practices. Originality/value The authors create an organizational framework for a fragmented body of literature by identifying three research domains for green practices based on a systematic review of recently published hospitality articles (2000-2014). They challenge existing definitions of green practices and propose an accurate definition tailored to the hospitality context.
Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy

Near-infrared spectroscopy has been used for measurement of changes in cerebral Hb concentrations in infants to study cerebral oxygenation and hemodynamics. In this study, measurements by time-resolved spectroscopy (TRS) were performed in 22 neonates to estimate the values of light absorption coefficient and reduced scattering coefficient (μ's), cerebral Hb oxygen saturation (Sco2), cerebral blood volume (CBV), and differential pathlength factor (DPF), and the relationships between postconceptional age and μ's, Sco2, CBV, and DPF were investigated. A portable three-wavelength TRS system with a probe attached to the head of the neonate was used. The mean μ's values at 761, 795, and 835 nm in neonates were estimated to be (mean ± SD) 6.46 ± 1.21, 5.90 ± 1.15 and 6.40 ± 1.16/cm, respectively. There was a significant positive relationship between postconceptional age and μ's at those three wavelengths. The mean Sco2 value was calculated to be 70.0 ± 4.6%, and postconceptional age and Sco2 showed a negative linear relationship. The mean value of CBV was 2.31 ± 0.56 mL/100 g. There was a significant positive relationship between postconceptional age and CBV. The mean DPF values at 761, 795, and 835 nm were estimated to be 4.58 ± 0.41, 4.64 ± 0.46, and 4.31 ± 0.42, respectively. There was no relationship between postconceptional age and DPF at those three wavelengths. The results demonstrated that our near-infrared TRS method can be used to monitor μ's, Sco2, CBV, and DPF in the neonatal brain at the bedside in an intensive care unit.
Mammographic Images Enhancement and Denoising for Breast Cancer Detection Using Dyadic Wavelet Processing

Mammography is the most effective method for the early detection of breast diseases. However, the typical diagnostic signs such as microcalcifications and masses are difficult to detect because mammograms are low-contrast and noisy images. In this paper, a novel algorithm for image denoising and enhancement based on dyadic wavelet processing is proposed. The denoising phase is based on a local iterative noise variance estimation. Moreover, in the case of microcalcifications, we propose an adaptive tuning of enhancement degree at different wavelet scales, whereas in the case of mass detection, we developed a new segmentation method combining dyadic wavelet information with mathematical morphology. The innovative approach consists of using the same algorithmic core for processing images to detect both microcalcifications and masses. The proposed algorithm has been tested on a large number of clinical images, comparing the results with those obtained by several other algorithms proposed in the literature through both analytical indexes and the opinions of radiologists. Through preliminary tests, the method seems to meaningfully improve the diagnosis in the early breast cancer detection with respect to other approaches.
Return Signal Momentum

A new type of momentum based on past return signs is introduced, called Returns Signal Momentum. This is mainly driven by sign dependence, which is positively related to average return and negatively related to return volatility. An empirical application using a universe of commodity and financial futures offers supporting evidence to this momentum factor. Investment strategies based on Returns Signal Momentum result in higher returns and Sharpe ratio and lower drawdown when compared to Time Series Momentum and other benchmark strategies. Overall, Returns Signal Momentum can benefit investors as an effective strategy for speculation and hedging.
The impact of labour unions on external auditor selection and audit scope: evidence from the Korean market

ABSTRACT We examine whether labour unions influence external auditor selection and audit scope. As a major user group of financial information, labour unions likely demand financial information of high quality and thus high-quality audits. As a union’s request for wage increases is likely strong when a firm is performing well, management facing wage negotiations with the labour union has incentives to manipulate earnings downward and may therefore prefer auditors who allow more discretion. Using union data unique to Korea during 2005–2008, we find that firms with a stronger labour union tend to choose higher-quality auditors (i.e. Big N or industry specialist auditors). We also find that unionization is negatively (positively) associated with positive (negative) abnormal audit fees and audit hours, and the effects are more pronounced when the union is stronger and more active. Given that departures from normal audit fees and audit hours in either direction arguably impair audit quality, this finding is consistent with our prediction of unions’ demand for high-quality audits. Overall, our findings suggest that labour unions play an important role in determining audit quality.