Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of treatment modalities in pancreatic pseudocyst: A population based study

BACKGROUND Current therapeutic techniques for pancreatic pseudocyst include surgical management with a laparoscopic approach or an open surgical procedure, percutaneous catheter drainage and endoscopic drainage. Yet it remains controversial whether different treatment approaches affect inpatient outcome. AIM To investigate inpatient outcome of different treatment approaches in treating pancreatic pseudocyst. METHODS Here we conducted a retrospective analysis of pancreatic pseudocyst-associated hospitalizations using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample. International Classification of Diseases 10 clinical modification and procedure codes are used. RESULTS A total of 7060 patients meeting the above criteria were identified. Our study revealed laparoscopic approach associated with the lowest rate of red blood cell transfusion (P < 0.001), and it had lower short-term complications including acute renal failure (P = 0.01), urinary tract infection (P = 0.01), sepsis (P < 0.001) and acute respiratory failure (P = 0.01). Laparoscopic surgical approach associated with the shortest mean length of stay (P = 0.009), and it had the lowest total charge (P = 0.03). All three modalities have similar inpatient mortality (P = 0.28). The study also revealed that percutaneous drainage associated with more emergent admission (P < 0.001), rural hospital performs the most open surgical drainage (P < 0.001) and patients who received laparoscopic drainage are more likely to be discharged home (P < 0.001). CONCLUSION Laparoscopic drainage of pancreatic pseudocysts associated with the least short-term complications and had better outcomes comparing to percutaneous and open surgical drainage from 2016 National Inpatient Sample database.
The correlation of BER protein, IRF3 with CD8+ T cell and their prognostic significance in upper tract urothelial carcinoma

Objectives Tumor-infiltrating lymphocytes (TILs) play a crucial role in anti-tumor immunity. Basic studies have found that stimulator of interferon genes (STING), activated by sensing DNA damage, plays a role in recruiting and activating TILs in tumors. However, the correlation between base excision repair (BER) pathway, STING pathway and TILS and their effect on prognosis in upper urinary tract urothelial carcinoma (UTUC) are still unclear. The aim of this study was to investigate the prognostic effect of those proteins expression for disease-free survival (DFS) and overall survival (OS) and explore the correlation between these makers. Methods We evaluated immunohistochemical expression of BER pathway (APE1, NTH1, OGG1, XRCC1, polβ), STING pathway (STING, IRF3), TILs (CD4, CD8, CD20) and PD-L1, PD-L2 in 88 UTUC patients to determine the predictive significance in DFS, OS and the correlation between them. Results We found that interferon regulatory factor3 (IRF3) (HR: 0.451, 95% CI 0.243–0.837, p=0.024) and CD8 (HR: 0.522, 95% CI 0.295–0.926, p=0.014) are independent prognostic factors for DFS, APE1 (HR: 1.932, 95% CI 1.005–3.714, P=0.048), polβ (HR: 2.620, 95% CI 1.373–5.000, P=0.003), CD8 (HR: 0.323, 95% CI 0.151–0.693, P=0.004) were independent prognostic factors for OS. A model consisting of stage, grade, lymphovascular invasion and expression of APE1, polβ, IRF3, CD4, CD8 that predicts 3-year OS. Furthermore, DNA damage repair protein polβ is associated with CD8+ T cells in TME. Conclusion We found that DNA damage, IRF3 and TILs are independent predictors for prognosis. We also provided clinical evidence that DNA damage repair-activated STING pathway can induce the recruitment and activation of TILs, which is consistent with preclinical models.
Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation Of Ocimum Gratissimum Essential Oil: Optimised Synthesis, In Vitro Release And Bioactivity

Background The encapsulation of plant essential oils (EOs) with polymeric materials (e.g. chitosan (CS) and N, N, N-trimethyl chitosan (TMC)) and the further reduction of the polymers into their nano sizes are gaining research interest in nanotechnology due to potential applications in medical drug delivery systems as well as the food and pharmaceutical industry. The present study reports a novel approach for the synthesis of Ocimum gratissimum essential oil (OGEO)-loaded CS and TMC nanoparticles with distinct bioactive and physiochemical properties. Methods The OGEO-loaded CS and TMC nanoparticles were characterised using various microscopic and spectroscopic techniques. The bioactive compounds in Ocimum gratissimum methanolic extract (OG-MeOH) and EOs was evinced with gas chromatography-mass spectrometry (GC-MS). Total phenolic content (TPC) of OGEO and OG-MeOH was determined using the Folin-Ciocalteu method. The in vitro drug release kinetic pattern was ascertained by membrane dialysis, while antioxidant activity was determined by the 2,2-diphenyl-1picrylhydrozyl (DPPH) free radical scavenging method. The disc diffusion method was used for antibacterial activity evaluation, while MTT and a trypan blue dye exclusion assay were used to assess cytotoxic activity on MDA-MB-231 breast cancer cells. Results GC-MS analysis revealed components that have not been previously reported for Ocimum gratissimum. The maximum OGEO cumulative drug release percentage in vitro was observed at pH 3 for both OGEO-loaded chitosan nanoparticles (OGEO-CSNPs) and OGEO-loaded N, N, N-trimethyl chitosan nanoparticles (OGEO-TMCNPs). The antioxidant activity of OGEO-CSNPs and OGEO-TMCNPs never reached a steady state after 75 h. OGEO-TMCNPs exhibited antibacterial activity at a lower concentration for both Gram-negative and Gram-positive food pathogens. In vitro cytotoxicity revealed the increased toxicity of OGEO-TMCNPs on MDA-MB-231 breast cancer cell lines. Conclusion OGEO-loaded CS and TMC nanoparticles were synthesised using a novel material optimisation approach. The synthesised nanoparticles have shown a promising application in the pharmaceutical and food industries.
Who should you be following? The top 100 social media influencers in orthopaedic surgery

BACKGROUND Social media has been credited with the potential to transform medicine, and Twitter was recently named “an essential tool” for the academic surgeon. Despite this, peer-to-peer and educational influence on social media has not been studied within orthopaedic surgery. This knowledge is important to identify who is controlling the conversation about orthopaedics to the public. We hypothesized that the plurality of top influencers would be sports medicine surgeons, that social media influence would not be disconnected from academic productivity, and that some of the top social media influencers in orthopaedic surgery would not be orthopaedic surgeons. AIM To identify the top 100 social media influencers within orthopaedics, characterize who they are, and relate their social media influence to academic influence. METHODS Twitter influence scores for the topic “orthopaedics” were collected in July 2018 using Right Relevance software. The accounts with the top influence scores were linked to individual names, and the account owners were characterized with respect to specialty, subspecialty, practice setting, location, board certification, and academic Hirsch index (h-index). RESULTS Seventy-eight percent of top influencers were orthopaedic surgeons. The most common locations included California (13%), Florida (8%), New York (7%), United Kingdom (7%), Colorado (6%), and Minnesota (6%). The mean academic h-index of the top influencers (n = 79) was 13.67 ± 4.12 (mean ± 95%CI) and median 7 (range 1-89) (median reported h-index of academic orthopaedic faculty is 5 and orthopaedic chairpersons is 13). Of the 78 orthopaedic surgeons, the most common subspecialties were sports medicine (54%), hand and upper extremity (18%), and spine (8%). Most influencers worked in private practice (53%), followed by academics (17%), privademics (14%), and hospital-based (9%). All eligible orthopaedic surgeons with publicly-verifiable board certification statuses were board-certified (n = 74). CONCLUSION The top orthopaedic social media influencers on Twitter were predominantly board-certified, sports-medicine subspecialists working in private practice in the United States. Social media influence was highly concordant with academic productivity as measured by the academic h-index. Though the majority of influencers are orthopaedic surgeons, 22% of top influencers on Twitter are not, which is important to identify given the potential for these individuals to influence patients’ perceptions and expectations. This study also provides the top influencer network for other orthopaedic surgeons to engage with on social media to improve their own social media influence.
NDT_A_217069 2799..2808

Fátima Martinez Slomp Tiago S Bara Gledson Luiz Picharski Mara L Cordeiro 1–4 1Faculdades Pequeno Príncipe, Curitiba, Brazil; 2Guarapuava Centre-West University, Guarapuava, Brazil; 3Research Institute Pelé Pequeno Príncipe, Curitiba, Brazil; 4Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA Background: Several studies worldwide have pointed to depression and anxiety symptoms as being related to adolescent smoking. The aim of this study was to investigate, the potential link of cigarette smoking with depression, anxiety, and suicidal ideation and the influence of gender on these relationships in Brazilian adolescents. Methods: Associations of smoking with Children Depressive Inventory version 2 (CDI2) scores, Hamilton Anxiety Scale (HAM-A) scores, and poor school performance (i.e., grade retention) were examined in 988 Brazilian students (age range, 11–17 years) enrolled in 82 public and private schools. Logistic regression modeling was employed and the resultant odds ratios (ORs) are reported with 95% CIs. Results: Of 988 participants, 240 (24.3%) were smokers. Mean (±standard error) HAM-A scores were higher for smokers (21.1 ± 9.7) than nonsmokers (15.4 ± 8.6; p < 0.0001). Relative to nonsmokers, smokers had higher total CDI2 scores (p = 0.033), and higher scores for the CDI2 domains of Emotional Problems (p = 0.023), Negative Self-esteem (p < 0.001), and Functional Problems (p = 0.046). Suicidal ideation was common among smokers with depressive symptoms (54.2%). Smoking was associated with being held back three grades (p < 0.001). Female smokers were more likely to report suicidal ideation than male smokers (p = 0.020). Logistic regression modeling revealed significant associations of suicidal ideation with being female (OR, 1.81; 95% CI, 1.38–2.37), being a female smoker (OR, 2.05; 95%CI, 1.51–2.80), and having a HAM-A score > 16 (OR, 2.18; 95% CI, 1.66–2.86). Conclusion: Smoking was found to be associated with anxiety symptoms, depressive symptoms, and poor school performance in Brazilian adolescents; and female smokers reported more suicidal ideation than male smokers.
CMAR_A_219699 8669..8698

1Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran; 2Student Research Committee, Iran University of Medical Sciences, Tehran, Iran; 3Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; 4Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; 5Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; 6Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran Abstract: Nearly half of patients with colorectal cancer (CRC), the third leading cause of
Morphological Analysis of Size and Shape (MASS): An integrative software program for morphometric analyses of leaves

Premise Morphometric analysis is a common approach for comparing and categorizing botanical samples; however, completing a suite of analyses using existing tools may require a multi‐stage, multi‐program process. To facilitate streamlined analysis within a single program, Morphological Analysis of Size and Shape (MASS) for leaves was developed. Its utility is demonstrated using exemplar leaf samples from Acer saccharum, Malus domestica, and Lithospermum. Methods Exemplar samples were obtained from across a single tree (Acer saccharum), three trees in the same species (Malus domestica), and online, digitized herbarium specimens (Lithospermum). MASS was used to complete simple geometric measurements of samples, such as length and area, as well as geometric morphological analyses including elliptical Fourier and Procrustes analyses. Principal component analysis (PCA) of data was also completed within the same program. Results MASS is capable of making desired measurements and analyzing traditional morphometric data as well as landmark and outline data. Discussion Using MASS, differences were observed among leaves of the three studied taxa, but only in Malus domestica were differences statistically significant or correlated with other morphological features. In the future, MASS could be applied for analysis of other two‐dimensional organs and structures. MASS is available for download at https://github.com/gillianlynnryan/MASS.
Evaluation Of The Timing Of Intravitreal Bevacizumab Injection As Adjuvant Therapy To Panretinal Photocoagulation In Patients With Diabetic Macular Edema Secondary To Diabetic Retinopathy

Objective To evaluate the difference in intravitreal bevacizumab (IVB) injection timing as adjuvant therapy to panretinal photocoagulation in patients with diabetic retinopathy combined with diabetic macular edema. Methods This was a retrospective nonrandomized study. Forty eyes with severe non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) were divided into two groups; the IVB injection prior to, or after, panretinal photocoagulation. Changes in central macular thickness between the two groups were measured. Results There was no significant difference in change in central macular thickness between two groups after treatment (p=0.66), neither in eyes with severe NPDR groups (p=0.48) nor eyes with PDR (p=0.82). Conclusion IVB injection after panretinal photocoagulation gives insignificant difference in changes in central macular thickness with injection prior to laser treatment in patients with diabetic retinopathy combined with diabetic macular edema.
Building Competitive Advantage through Innovation and Customer Value to Foster Purchase Intention

The purpose of this study was to analyze purchase intention through competitive advantage with innovation and customer value as the causes. The population of this study was consumers of MSME's-produced cake products in West Sumatera, Indonesia. The sample size consisted of 160 people. The sample was drawn by cluster random sampling. The data were collected by means of questionnaire of which validity and reliability had been tested. The data were analyzed using PLS Smart 3.0. The results of this study showed that cake innovation and customer value had a significant effect on competitive advantage of cake. Innovation did not directly affect consumers' desire to buy jicama cake. However, cake innovation had an indirect influence on the desire to buy cake. Meanwhile, customer value and competitive advantage had a significant influence on the desire to buy cake. Customer value also had an indirect influence on consumers' desire to buy cake in Indonesia.
Private Reader: Using Eye Tracking to Improve Reading Privacy in Public Spaces

Reading in public spaces can often be tricky if we wish to keep the contents away from the prying eye. We propose Private Reader, an eye-tracking approach towards maintaining privacy while reading by rendering only the portion of text that is gazed by the reader. We conducted a user study by evaluating for both the reader and observer in terms of privacy, reading comfort, and reading speed for three reading modes; normal, underscored, and scrambled text. "Scrambled" performs best in terms of perceived effort and frustration for the shoulder surfer. Our contribution is threefold; we developed a system to preserve privacy by rendering only the text at gaze-point of the reader, we conducted a user study to evaluate user preferences and subjective task load, and we suggested several scenarios where Private Reader is useful in public spaces.
Integrating HCI Perspective into a Mobile Software Development Team: Strategies and lessons from the field

Software engineers are traditionally concerned with performance and capabilities of mobile applications, while Human-Computer Interaction (HCI) approaches remain underused in many cases of industry everyday practice, especially in smaller companies, running on a tight schedule. The present paper reports a set of strategies empirically outlined by HCI and mobile development teams working integrated into different stages of the development lifecycle while keeping project constraints in mind, aiming to provide practical ways of incorporating academic knowledge about human factors into the development of mobile applications. We also discuss some lessons learned, which we believe may favor a more significant application of HCI issues in the mobile industry.
A Comparative Study between Carbon Tax and Carbon Trading Scheme Based on DSGE

We employ an extended dynamic stochastic general equilibrium (DSGE) model with Chinese macroeconomic data to evaluate suitable carbon mitigation policies in China. The results show that the carbon tax has a greater economic impact with a shorter duration, which is suitable for the rigorous reduction target. The carbon trading scheme has a relatively small impact on the economy and is more suitable for long-term emission reduction demand. Energy consumption structural adjustment promotes carbon emission reduction and technology shock dominates in macroeconomic fluctuation when the economy faces multiple different exogenous shocks.
AudioTouch: Minimally Invasive Sensing of Micro-Gestures via Active Bio-Acoustic Sensing

We present AudioTouch, a minimally invasive approach for sensing micro-gestures using active bio-acoustic sensing. It only requires attaching two piezo-electric elements, acting as a surface mounted speaker and microphone, on the back of the hand. It does not require any instrumentation on the palm or fingers; therefore, it does not encumber interactions with physical objects. The signal is rich enough to detect small differences in micro-gestures with standard machine-learning classifiers. This approach also allows for the discrimination of different levels of touch-force, further expanding the interaction vocabulary. We conducted four experiments to evaluate the performances of AudioTouch: a user study for measuring the gesture recognition accuracy, a follow-up study investigating the ability to discriminate different levels of touch-force, an experiment assessing the cross-session robustness, and, a systematic evaluation assessing the effect of sensor placement on the back of the hand.
Parent Disciplining Styles to Prevent Children's Misbehaviors toward a Social Robot

In this paper we present a lab study on robot abuse by children. 61 Japanese children of ages 7-9 interacted individually with Robovie, a social robot, in a context that promoted children's free disruptive behaviors towards the robot. We compared the robot's use of an adaptation of a parental discipline strategy, the so-called love-withdrawal technique, to a similar set of robot behaviors that lacked any specific strategy (neutral condition). The main insight we gained was that perhaps we should better not focus on general robot behaviors to try to fit all children, but rather, we should adapt the robot behaviors to children's individual differences. For instance, we found that the love-withdrawal-based strategy was significantly more effective in children of age 8-9 than on children of 7.
Hardware Design of DC/CFL Intra-Prediction Decoder for the AV1 Codec

This paper presents a dedicated hardware design for the DC and Chroma from Luma (CFL) intra-prediction modes of AV1 decoder. The hardware was designed to reach real-time when processing UHD 4K videos. The AV1 codec is an open-source and royalties-free video coding, which was developed by the AOMedia group, this group is composed of multiple companies like Google, Netflix, AMD, ARM, Intel, Nvidia, Microsoft, Mozilla and others. The proposed solution can support all 19 block sizes allowed in AV1 encoder, being able to process UHD 4K videos at 60 frames per second. The DC/CFL modules were synthesized to the TSMC 40 nm cells library targeting the frequency of 132.1 MHz. Synthesis results show the proposed hardware used 89.39 Kgates and a power dissipation of 7.96mW.
Help!: I'm Stuck, and there's no F1 Key on My Tablet!

Older adults are often considered to be less frequent adopters of new technologies, in part due to increased efforts required to learn new interaction paradigms, especially if these need to overcome long-established mental models of technology use. Many current interfaces such as mobile devices often do not incorporate elements that align with older adults' models of use: explicit help menus, user manuals, navigation affordances. The lack of such reassuring elements may cause anxiety to those trying to learn interaction paradigms that are new to them. This paper details the help and support paradigms behind the design of a contextual support interface for tablet devices and describes the results of a usability evaluation with older adult participants.
Application of UTAUT Theory in Higher Education Online Learning

This research is a causal quantitative research based on the Unified Theory of Acceptance and Use of Technology model (UTAUT). The object of this study is students who take online learning programs. Data collection methods use primary data by distributing questionnaires. This research uses respondent consist of 365 students from various online learning study program. The results of this study are that variables: performance expectancy, effort expectancy, quality of service, and personal innovativeness affect the behavioral intention, while the influence of lecturer has no effect on behavioral intention. Besides behavioral intention influences use behavior while facilitating condition has no effect on use behavior.
Factors Influencing Empathic Behaviors for Virtual Agents: -Examining about the Effect of Embodiment-

Empathy is important for smooth interaction. In this research, we focused on EQ (Empathy Quotient), which is an index to measure individuals' empathic ability, and analyzed behavior related to EQ, particularly the effect of participants' embodiment on empathic behavior. In the experiment, participants played a ball-tossing game with two agents. The experimental task was created by adapting the Cyberball game that has been used in studies of social psychology. We conducted the experiment under two conditions: an equitable scenario where the two agents toss evenly to participants and other agents; and an inequitable scenario where only one agent tosses only to participants. Then we compared the number of tosses performed by each participants. As a result, we found that the participants with high EQ tended to exclude the agent who did not receive tosses from the other agent, but that this exclusion was alleviated by embodiment.