Miracle-dz/UniFAR-FTUs huggingface dataset:
16 M ar 2 01 1 Search for a Dark Matter annihilation signal from the Galactic Center halo with

A. Abramowski, F. Acero, F. Aharonian, 4, 5 A.G. Akhperjanian, 5 G. Anton, A. Barnacka, U. Barres de Almeida, ∗ A.R. Bazer-Bachi, Y. Becherini, 13 J. Becker, B. Behera, K. Bernlöhr, 16 A. Bochow, C. Boisson, J. Bolmont, P. Bordas, V. Borrel, J. Brucker, F. Brun, P. Brun, T. Bulik, I. Büsching, S. Carrigan, S. Casanova, 14 M. Cerruti, P.M. Chadwick, A. Charbonnier, R.C. G. Chaves, A. Cheesebrough, L. -M. Chounet, A.C. Clapson, G. Coignet, J. Conrad, M. Dalton, M.K. Daniel, I.D. Davids, B. Degrange, C. Deil, H.J. Dickinson, 23 A. Djannati-Atäı, W. Domainko, L.O’C. Drury, F. Dubois, G. Dubus, J. Dyks, M. Dyrda, K. Egberts, P. Eger, P. Espigat, L. Fallon, C. Farnier, S. Fegan, F. Feinstein, M.V. Fernandes, A. Fiasson, G. Fontaine, A. Förster, M. Füßling, Y.A. Gallant, H. Gast, L. Gérard, D. Gerbig, B. Giebels, J.F. Glicenstein, B. Glück, P. Goret, D. Göring, J.D. Hague, D. Hampf, M. Hauser, S. Heinz, G. Heinzelmann, G. Henri, G. Hermann, J.A. Hinton, A. Hoffmann, W. Hofmann, P. Hofverberg, D. Horns, A. Jacholkowska, O.C. de Jager, C. Jahn, M. Jamrozy, I. Jung, M.A. Kastendieck, K. Katarzyński, U. Katz, S. Kaufmann, D. Keogh, M. Kerschhaggl, D. Khangulyan, B. Khélifi, D. Klochkov, W. Kluźniak, T. Kneiske, Nu. Komin, K. Kosack, R. Kossakowski, H. Laffon, G. Lamanna, D. Lennarz, T. Lohse, A. Lopatin, C. -C. Lu, V. Marandon, A. Marcowith, J. Masbou, D. Maurin, N. Maxted, T.J.L. McComb, M.C. Medina, J. Méhault, R. Moderski, E. Moulin, C.L. Naumann, M. Naumann-Godo, M. de Naurois, D. Nedbal, D. Nekrassov, † N. Nguyen, B. Nicholas, J. Niemiec, S.J. Nolan, S. Ohm, J-F. Olive, E. de Oña Wilhelmi, B. Opitz, M. Ostrowski, M. Panter, M. Paz Arribas, G. Pedaletti, G. Pelletier, P.-O. Petrucci, S. Pita, G. Pühlhofer, M. Punch, A. Quirrenbach, M. Raue, 3 S.M. Rayner, A. Reimer, O. Reimer, M. Renaud, R. de los Reyes, F. Rieger, 34 J. Ripken, L. Rob, S. Rosier-Lees, G. Rowell, B. Rudak, C.B. Rulten, J. Ruppel, F. Ryde, V. Sahakian, 5 A. Santangelo, R. Schlickeiser, F.M. Schöck, A. Schönwald, U. Schwanke, S. Schwarzburg, S. Schwemmer, A. Shalchi, M. Sikora, J.L. Skilton, H. Sol, G. Spengler, L. Stawarz, R. Steenkamp, C. Stegmann, F. Stinzing, I. Sushch, ‡ A. Szostek, 25 J.-P. Tavernet, R. Terrier, O. Tibolla, M. Tluczykont, K. Valerius, C. van Eldik, § G. Vasileiadis, C. Venter, J.P. Vialle, A. Viana, P. Vincent, M. Vivier, H.J. Völk, F. Volpe, S. Vorobiov, M. Vorster, S.J. Wagner, M. Ward, A. Wierzcholska, A. Zajczyk, A.A. Zdziarski, A. Zech, and H. -S. Zechlin
Optical mechanisms regulating emmetropisation and refractive errors: evidence from animal models

Our current understanding of emmetropisation and myopia development has evolved from decades of work in various animal models, including chicks, non‐human primates, tree shrews, guinea pigs, and mice. Extensive research on optical, biochemical, and environmental mechanisms contributing to refractive error development in animal models has provided insights into eye growth in humans. Importantly, animal models have taught us that eye growth is locally controlled within the eye, and can be influenced by the visual environment. This review will focus on information gained from animal studies regarding the role of optical mechanisms in guiding eye growth, and how these investigations have inspired studies in humans. We will first discuss how researchers came to understand that emmetropisation is guided by visual feedback, and how this can be manipulated by form‐deprivation and lens‐induced defocus to induce refractive errors in animal models. We will then discuss various aspects of accommodation that have been implicated in refractive error development, including accommodative microfluctuations and accommodative lag. Next, the impact of higher order aberrations and peripheral defocus will be discussed. Lastly, recent evidence suggesting that the spectral and temporal properties of light influence eye growth, and how this might be leveraged to treat myopia in children, will be presented. Taken together, these findings from animal models have significantly advanced our knowledge about the optical mechanisms contributing to eye growth in humans, and will continue to contribute to the development of novel and effective treatment options for slowing myopia progression in children.
1 ERP evidence of implicit metric structure during 2 silent reading 3

Under the Implicit Prosody Hypothesis, readers generate prosodic structures during silent 10 reading that can direct their real-time interpretations of the text. In the current study, we 11 investigated the processing of implicit meter by recording event-related potentials (ERPs) while 12 participants read a series of 160 rhyming couplets, where the rhyme target was always a stress13 alternating noun-verb homograph (e.g. permit, which is pronounced PERmit as a noun and perMIT 14 as a verb). The target had a strong-weak or weak-strong stress pattern, which was either consistent 15 or inconsistent with the stress expectation generated by the couplet. Inconsistent strong-weak 16 targets elicited negativities between 80–155 ms and 325–375 ms relative to consistent strong-weak 17 targets; inconsistent weak-strong targets elicited a positivity between 365–435 ms relative to 18 consistent weak-strong targets. These results are largely consistent with effects of metric violations 19 during listening, demonstrating that implicit prosodic representations are similar to explicit 20 prosodic representations. 21
Further Exploration of Sucrose-Citric Acid Adhesive: Synthesis and Application on Plywood

The development of eco-friendly adhesives is a major research direction in the wood-based material industry. Previous research has already demonstrated the mixture of sucrose and citric acid could be utilized as an adhesive for the manufacture of particleboard. Herein, based on the chemical characteristics of sucrose, a synthesized sucrose-citric acid (SC) adhesive was prepared, featuring suitable viscosity and high solid content. The investigation of synthesis conditions on the bond performance showed that the optimal mass proportion between sucrose and citric acid was 25/75, the synthesis temperature was 100 °C, and the synthesis time was 2 h. The wet shear strength of the plywood bonded with SC adhesive, which was synthesized at optimal conditions and satisfied the China National Standard GB/T 9846-2015. The synthesis mechanism was studied by both 13C NMR analysis and HPLC, and the chemical composition manifesting caramelization reaction occurred during the synthesis process. The results of ATR FT-IR indicated the formation of a furan ring, carbonyl, and ether groups in the cured insoluble matter of the SC adhesive, which indicated dehydration condensation as the reaction mechanism between sucrose and citric acid.
Nisin J, a Novel Natural Nisin Variant, Is Produced by Staphylococcus capitis Sourced from the Human Skin Microbiota

This study describes the characterization of nisin J, the first example of a natural nisin variant, produced by a human skin isolate of staphylococcal origin. Nisin J displays inhibitory activity against a wide range of bacterial targets, including MRSA. This work demonstrates the potential of human commensals as a source for novel antimicrobials that could form part of the solution to antibiotic resistance across a broad range of bacterial pathogens. ABSTRACT The skin microbiota is thought to play a key role in host protection from infection. Nisin J is a novel nisin variant produced by Staphylococcus capitis APC 2923, a strain isolated from the toe web space area in a screening study performed on the human skin microbiota. Whole-genome sequencing and mass spectrometry of the purified peptide confirmed that S. capitis APC 2923 produces a 3,458-Da bacteriocin, designated nisin J, which exhibited antimicrobial activity against a range of Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and Cutibacterium acnes. The gene order in the nisin J gene cluster (nsjFEGBTCJP) differs from that of other nisin variants in that it is lacking the nisin regulatory genes, nisRK, as well as the nisin immunity gene nisI. Nisin J has 9 amino acid changes compared to prototypical nisin A, with 8 amino acid substitutions, 6 of which are not present in other nisin variants (Ile4Lys, Met17Gln, Gly18Thr, Asn20Phe, Met21Ala, Ile30Gly, Val33His, and Lys34Thr), and an extra amino acid close to the C terminus, rendering nisin J the only nisin variant to contain 35 amino acids. This is the first report of a nisin variant produced by a Staphylococcus species and the first nisin producer isolated from human skin. IMPORTANCE This study describes the characterization of nisin J, the first example of a natural nisin variant, produced by a human skin isolate of staphylococcal origin. Nisin J displays inhibitory activity against a wide range of bacterial targets, including MRSA. This work demonstrates the potential of human commensals as a source for novel antimicrobials that could form part of the solution to antibiotic resistance across a broad range of bacterial pathogens.
CMAR_A_223271 9321..9330

Zhiyu Qiu * Lujun Shen* Shuanggang Chen* Han Qi 1,3 Fei Cao Lin Xie Weijun Fan 1Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China; 2Zhong Shan Medical School, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China; 3State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
1 0 O ct 2 01 7 Why black hole information loss is paradoxical

I distinguish between two versions of the black hole information-loss paradox. The first arises from apparent failure of unitarity on the spacetime of a completely evaporating black hole, which appears to be nonglobally-hyperbolic; this is the most commonly discussed version of the paradox in the foundational and semipopular literature, and the case for calling it ‘paradoxical’ is less than compelling. But the second arises from a clash between a fully-statistical-mechanical interpretation of black hole evaporation and the quantum-field-theoretic description used in derivations of the Hawking effect. This version of the paradox arises long before a black hole completely evaporates, seems to be the version that has played a central role in quantum gravity, and is genuinely paradoxical. After explicating the paradox, I discuss the implications of more recent work on AdS/CFT duality and on the ‘Firewall paradox’, and conclude that the paradox is if anything now sharper. The article is written at a (relatively) introductory level and does not assume advanced knowledge of quantum
The problematic implementation of community-based ecotourism in Indonesia: A case study in ecotourism of Gili Labak-East Java

This study aimed at analyzing the implementation of Community-Based Ecotourism (CBE) principles in managing the Ecotourism of Gili Labak, East Java. This study was qualitative and descriptive. The primary data were obtained through observation and interview to certain informants (management team, tour guide, sellers/shopkeepers, lodging and rental owners, local citizen, travel agent, local academicians, local government), while the secondary data were gained from apposite literature and government regulation documents. This study was conducted over a year, from January to December 2018. The research results showed that, generally, the CBE principles were not seriousely implemented yet in the ecotourism management of Gili Labak. Conservation principles were not considered important by the management team, and this was neglected as their focus was concentrated on their efforts to attract tourists and as many as possible. In addition, there was also an inadequacy in culture conserving efforts and the lack of knowledge and skill of the management team related to this issue. This study is essential for the ecotourism discourse, community development, and environmental education, and in cultivating students’ basic skills in planning, developing, managing and marketing of certain ecotourism attractiveness to support sustainable development initiatives. The CBE study in Indonesia, mainly in East Java was limited. There has been no CBE study in Gili Labak. This study is valuable for these endeavors in developing the conservation of the ecotourism area and in determining a proper policy by the Indonesian government which can contribute to great benefits for the local community.
The quality of financial reporting in China: An examination from an accounting restatement perspective

This study uses restatements to reveal the poor quality of past accounting information reported within China’s capital market. We show that up to a quarter of listed firms in mainland China explicitly admitted the poor quality of their financial information by restating their previous financial reports between 1999 and 2005. Many of these firms managed their earnings mainly via below-the-line items to avoid losses and promote survival, rather than to support refinancing goals. Such poor-quality financial reporting is more likely among firms that have weaker profitability and a shareholder base that is state-controlled, with diffused ownership and a relatively low proportion of shares held by institutional investors. Furthermore, we find the market to be relatively insensitive to such admissions. Investors’ reactions capture only the earnings information of the current reported year, rather than also reflecting the concurrently revealed correction of past financial hina Journal of Accounting Research. Founded by Sun Yat-sen University and City hosting by Elsevier B.V. All rights reserved. (M. Wu). the author and do not necessarily reflect the views of Morgan Stanley or its affiliates.
Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis

Insulin promotes glucose uptake by triggering the translocation of glucose transporter type 4 (GLUT4) from intracellular vesicles to the plasma membrane through exocytosis. GLUT4 exocytosis is a vesicle fusion event involving fusion of GLUT4-containing vesicles with the plasma membrane. For GLUT4 vesicle fusion to occur, GLUT4 vesicles must first be tethered to the plasma membrane. A key tethering factor in exocytosis is a heterooctameric protein complex called the exocyst. The role of the exocyst in GLUT4 exocytosis, however, remains incompletely understood. Here we first systematically analyzed data from a genome-scale CRISPR screen in HeLa cells that targeted virtually all known genes in the human genome, including 12 exocyst genes. The screen recovered only a subset of the exocyst genes, including exocyst complex component 7 (Exoc7/Exo70). Other exocyst genes, however, were not isolated in the screen, likely because of functional redundancy. Our findings suggest that selection of an appropriate exocyst gene is critical for genetic studies of exocyst functions. Next we developed an inducible adipocyte genome editing system that enabled Exoc7 gene deletion in adipocytes without interfering with adipocyte differentiation. We observed that insulin-stimulated GLUT4 exocytosis was markedly inhibited in Exoc7 KO adipocytes. Insulin signaling, however, remained intact in these KO cells. These results indicate that the exocyst plays a critical role in insulin-stimulated GLUT4 exocytosis in adipocytes. We propose that the strategy outlined in this work could be instrumental in genetically dissecting other membrane-trafficking pathways in adipocytes.
Functionalization of Carbon Nanomaterials for Biomedical Applications

Over the past decade, carbon nanostructures (CNSs) have been widely used in a variety of biomedical applications. Examples are the use of CNSs for drug and protein delivery or in tools to locally dispense nucleic acids to fight tumor affections. CNSs were successfully utilized in diagnostics and in noninvasive and highly sensitive imaging devices thanks to their optical properties in the near infrared region. However, biomedical applications require a complete biocompatibility to avoid adverse reactions of the immune system and CNSs potentials for biodegradability. Water is one of the main constituents of the living matter. Unfortunately, one of the disadvantages of CNSs is their poor solubility. Surface functionalization of CNSs is commonly utilized as an efficient solution to both tune the surface wettability of CNSs and impart biocompatible properties. Grafting functional groups onto the CNSs surface consists in bonding the desired chemical species on the carbon nanoparticles via wet or dry processes leading to the formation of a stable interaction. This latter may be of different nature as the van Der Waals, the electrostatic or the covalent, the π-π interaction, the hydrogen bond etc. depending on the process and on the functional molecule at play. Grafting is utilized for multiple purposes including bonding mimetic agents such as polyethylene glycol, drug/protein adsorption, attaching nanostructures to increase the CNSs opacity to selected wavelengths or provide magnetic properties. This makes the CNSs a very versatile tool for a broad selection of applications as medicinal biochips, new high-performance platforms for magnetic resonance (MR), photothermal therapy, molecular imaging, tissue engineering, and neuroscience. The scope of this work is to highlight up-to-date using of the functionalized carbon materials such as graphene, carbon fibers, carbon nanotubes, fullerene and nanodiamonds in biomedical applications.
Institutional Herding in Thailand Bond Market_ Sahaphon Vairungroj(แก้ไข)

Among many concerns about financial stability risks in asset management industry, herding has been considered as an important risk amplification channel. We find that institutional investor herd in Thailand bond market. In addition, herding is more intense in sell side and less pronounce in investment grade bond than unrated bond. This finding confirm our hypothesis that herding level is higher in the securities that have low liquidity and high information asymmetric. We also find the evidence of herding across quarter which found to be mostly driven by institutions following each other's trades rather than following their own trade in last quarter. More importantly, we find significant return reversals after herding period which indicated that institutional herding drive bond price away from its fundamental value and destabilize the bond price. So, in asset valuation and risk management, apart from study the impact of bond characteristic like interest rate or coupon rate only, in secondary market, financial institution may have to consider the fact that price of bond also depend on demand and supply of investors, which from our finding, associated with herding behavior. Regulator then should encourage the availability of information in bond market so that institution can get those information at lower cost. Institutions then will trade base on fundamental value more and rely on herding less, which can lead to higher stability in Thailand bond market
Injection Molding of Highly Filled Polypropylene-based Biocomposites. Buckwheat Husk and Wood Flour Filler: A Comparison of Agricultural and Wood Industry Waste Utilization

The study presents a comparative analysis for two types of polymer fillers used during the processing of polypropylene by the injection molding technique. The aim of the study was to assess the usefulness of buckwheat husk waste as an alternative to the widely used wood fiber fillers. For this purpose, we prepared composite samples containing 10, 30 and 50 wt % of the filler, which were subjected to mechanical tests, thermal analysis, and structural observations in order to evaluate and compare their properties. Additionally, we evaluated the effectiveness of the composite system’s compatibility by using maleic anhydride grafted polypropylene (PP-g-MA). The results of mechanical tests confirmed a more effective reinforcement mechanism for wood fibers; however, with the addition of PP-g-MA compatibilizer, these differences were significantly reduced: we observed a 14% drop for tensile modulus and 5% for strength. This suggests high susceptibility to this type of adhesion promoter, also confirmed by SEM observations. The paper also discusses rheological measurements conducted on a rotational rheometer, which allowed to confirm more favorable flow characteristics for composites based on buckwheat husks.
Evaluation of Uterine Artery Embolization on Myoma Shrinkage: Results from a Large Cohort Analysis

Objective: There are still contradictory opinions on the success rates of uterine artery embolization (UAE) for the treatment of myomas. In this scenario, our study aims to assess the effect of UAE on myoma shrinkage. Materials and Methods: The study included 337 women in reproductive age affected by a single symptomatic intramural myoma and declined surgery, undergoing UAE. The uterus and myoma diameters and volumes were determined on ultrasonographic scans before and 3, 6, and 12 months after the procedure. Results: The mean uterine volume before intervention was 226.46 ± 307.67 mm3, whereas myoma volume was 51.53 ± 65.53 mm3. Further myoma progression was registered in only four patients. In remaining women, uterus volume in average decreased for 149.99 ± 156.63 mm3, whereas myomas decreased for 36.57 ± 47.96 mm3. The mean volume reduction rate of the uterus was 49.54 ± 35.62 and for myoma was 57.58 ± 30.71. A significant decrease in both uterine and myoma volume was registered in every stage of the follow-up. The highest average decrease in uterine volume was in the first 3 months and myoma volume between 3 and 6 months following UAE. After 12 months follow-up, successful outcome (volume regression >50% respect to the baseline) was registered for uterus in 97.4% and for myoma in 67.9% of investigated patients. Conclusion: UAE was proven to allow a good success rate and can be considered as an effective alternative procedure for myoma treatment.
Development and validation of a knowledge, attitude, and practice questionnaire on nutrition-related cancer prevention for Iranian women

Background: Designing cancer prevention programs needs information on knowledge, attitude, and practice of the community. Unfortunately, this information is not available in Iran. Materials and Methods: We developed a questionnaire (NUTCANKAPQ) to assess the knowledge, attitude, and practice of Iranian women regarding cancer prevention dietary habits. We recruited women who had referred to public health-care centers in Tehran, Iran. To assess validity, we applied face, content, and construct validity methods. We performed test–retest approaches to assess reliability, and internal consistency of the questionnaire was assessed through Cronbach's alpha and intraclass correlation coefficients (ICCs). Results: Qualitative content validity was carried out by an expert panel, and internal consistency was deemed satisfactory (Cronbach's alpha, >0.6). We also observed high reliability in the questionnaire (ICC = 0.85). The mean (± standard deviation) scores for knowledge, attitude, and practice of study participants were 28.3 (±14.1), 67.1 (±18.9), and 53.7 (±8.3), respectively. The result of exploratory factor analysis, Kaiser–Meyer–Olkin (KMO), implied that the model was reasonably fit (KMO > 0.6). The final questionnaire included seventy items. Conclusion: NUTCANKAPQ is a valid and reliable tool for the assessment of cancer-related nutrition knowledge, attitude, and practice among the Iranian population. Application of NUTCANKAPQ may provide important clues for policy-making and improvement of cancer prevention programs among the Iranian population.