Miracle-dz/UniFAR-FTUs huggingface dataset:
Joint Beamforming for Multicell Multigroup Multicast With Per-Cell Power Constraints

This paper considers a joint beamforming design problem in the multicast broadcast single frequency network (MBSFN) scenario with multiple multicast groups that provide different multicast services. To solve the joint beamforming design among the cooperating base stations, which is also known as the joint processing scheme in the coordinated multipoint transmission (CoMP) defined in the long-term evolution-advanced (LTE-A) system, we devise different optimization techniques, such as semidefinite relaxation, fractional programming, and difference of convex (DC) programming. In this paper, per-cell power constraints are considered. In addition, we consider the design of higher rank transmission to increase the spectrum efficiency and the design of robust beamforming to alleviate performance degradation caused by imperfect channel state information. In the simulation results, we demonstrate the potential of the proposed algorithms in terms of the maximized minimum signal-to-interference plus noise ratio (SINR), and compare the proposed methods with the traditional MBSFN transmission scheme and the existing noncooperating multicast beamforming methods. The results show that the proposed methods, indeed, provide better performance. To complete the discussion, we also provide numerical results for the robust and nonrobust beamforming schemes in terms of the power consumption, feasibility ratio, and the histogram of the normalized SINR.
Women's Sexual Satisfaction as a Predictor of Well-Being in Same-Sex Versus Mixed-Sex Relationships

Structural equation modelling was used to assess the strengths of the links between sexual satisfaction and self-reported (a) relationship well-being, (b) mental health, and (c) physical health for women in same-sex (i.e., homosexual, n = 114) versus mixed-sex (i.e., heterosexual, n = 208) relationships. Participants came from a large-scale Internet study. Sexual satisfaction was found to be an extremely strong predictor of relational well-being, a strong predictor of mental health, and a weak to moderately strong predictor of physical health. A two-group comparison model indicated that the strength of these links was the same, regardless of whether the women were in a sexual relationship with a man or with another woman.
Structural and Biological Identification of Residues on the Surface of NS3 Helicase Required for Optimal Replication of the Hepatitis C Virus*

The hepatitis C virus (HCV) nonstructural protein 3 (NS3) is a multifunctional enzyme with serine protease and DEXH/D-box helicase domains. A crystal structure of the NS3 helicase domain (NS3h) was generated in the presence of a single-stranded oligonucleotide long enough to accommodate binding of two molecules of enzyme. Several amino acid residues at the interface of the two NS3h molecules were identified that appear to mediate a protein-protein interaction between domains 2 and 3 of adjacent molecules. Mutations were introduced into domain 3 to disrupt the putative interface and subsequently examined using an HCV subgenomic replicon, resulting in significant reduction in replication capacity. The mutations in domain 3 were then examined using recombinant NS3h in biochemical assays. The mutant enzyme showed RNA binding and RNA-stimulated ATPase activity that mirrored wild type NS3h. In DNA unwinding assays under single turnover conditions, the mutant NS3h exhibited a similar unwinding rate and only ∼2-fold lower processivity than wild type NS3h. Overall biochemical activities of the mutant NS3h were similar to the wild type enzyme, which was not reflective of the large reduction in HCV replicative capacity observed in the biological experiment. Hence, the biological results suggest that the known biochemical properties associated with the helicase activity of NS3h do not reveal all of the likely biological roles of NS3 during HCV replication. Domain 3 of NS3 is implicated in protein-protein interactions that are necessary for HCV replication.
Sex and Drugs: The Correlations of Injecting Drug Users' Risk Perception and Behavioral Patterns

A low-level blood-borne virus infection exists among Hungary's injecting drug users (IDUs). Assessing the relationship between risk perception and risk behaviors is necessary in order to predict future drug-injecting trends. During 1999 –and 2000, 197 IDUs were interviewed in Budapest using the Risk Assessment Questionnaire developed by the National Institute on Drug Abuse. Certain IDUs perceived high risks but did not act accordingly. High-risk perception of sexual behavior correlates with high-risk perception of drug use, which should be taken into consideration when planning intervention strategies targeting IDUs. Additional research with a larger sample is needed to explain our results in more detail. The study's limitations have been noted.
Survival analysis of 118 patients with systemic sclerosis

Abstract. Life‐table analysis based on the survival statistics of 118 Hungarian patients with systemic sclerosis suggests that the presence of skin hypo‐ and/or hyperpigmentation indicates a poor prognosis. Furthermore, truncal skin involvement, lung, cardiac, and renal manifestations, older age at the onset of disease, anaemia, hand deformity, and elevated erythrocyte sedimentation rate values, predict an unfavourable prognosis, whilst patients with exposure to chemicals shows a relatively favourable disease outcome.
An Economic Evaluation of Conception Strategies for Heterosexual Serodiscordant Couples with HIV-positive Male Partners

An economic evaluation of the three interventions to conceive without the sexual transmission of HIV between heterosexual, HIV-discordant couples with positive male partners can inform policy decisions to subsidize pregnancy planning in this setting, as there is currently no coverage as such in Ontario. A decision tree and Markov model were designed to determine the short and long-term outcomes of unprotected intercourse restricted to timed ovulation (UIRTO), sperm washing with intrauterine insemination (SWIUI), and unprotected intercourse restricted to timed ovulation with pre-exposure prophylaxis (UIRTO-PrEP). In the short-term, UIRTO was the most cost-effective strategy. In the long-term, cases of negligible HIV transmission risk determined UIRTO-PrEP as the preferred option, while SWIUI was the choice method when this risk was high. There remains a viable risk of HIV transmission between discordant couples during attempts to conceive that require the concurrent and subsidized use of UIRTO-PrEP or SWIUI to protect against HIV infection.
Spontaneous recovery of opsoclonusmyoclonus syndrome caused by enterovirus infection

Opsoclonus-myoclonus syndrome is a well recognised disease in children. The aetiology, except for neuroblastoma accounting for a few patients, remains unknown.1 Viral infection is one of the presumed physiopathological mechanisms. We report a case of opsoclonus-myoclonus syndrome due to enterovirus infection with spontaneous remission, no recurrence, and full recovery after 36 months follow up. A two year old girl, with a previously normal development, exhibited acute ataxia after a two day history of fever and vomiting. One day later, she developed myoclonic jerks and opsoclonus. Initially, she was febrile (39°C), irritable, and unable to sit …
THE LABORATORY IN CHEMISTRY EDUCATION: THIRTY YEARS OF EXPERIENCE WITH DEVELOPMENTS, IMPLEMENTATION, AND RESEARCH

Since the 1970s', the author was involved in researching the laboratory work. The research focused on the various issues concerning the laboratory as a unique learning environment. Most of these studies are included in this review. They were mainly conducted at the Department of Science Teaching, The Weizmann Institute of Science, in the context of chemistry curriculum development, implementation and evaluation. The review of the research studies and its related publication is organized under the following key issues: (1) The chemistry laboratory: A unique mode of learning, instruction, and assessment. (2). Assessing students' performance and achievement using different modes of presentation in the chemistry laboratory. (3) Students' attitude towards and interest in school chemistry laboratory work. (4) Students' perceptions of the laboratory classroom learning environment. [Chem. Educ. Res. Pract. : 2004, 5, 247-264]
Evolution of dorsal–ventral axis formation in arthropod appendages: H15 and optomotor‐blind/bifid‐type T‐box genes in the millipede Glomeris marginata (Myriapoda: Diplopoda)

Summary In Drosophila, the T‐box genes optomotor‐blind (omb) and H15 have been implicated in specifying the development of the dorso–ventral (DV) axis of the appendages. Results from the spider Cupiennius salei have suggested that this DV patterning system may be at least partially conserved. Here we extend the study of the DV patterning genes omb and H15 to a representative of the Myriapoda in order to add to the existing comparative data set and to gain further insight into the evolution of the DV patterning system in arthropod appendages. The omb gene of the millipede Glomeris marginata is expressed on the dorsal side of all appendages including trunk legs, maxillae, mandibles, and antennae. This is similar to what is known from Drosophila and Cupiennius and suggests that the role of omb in instructing dorsal fates is conserved in arthropods. Interestingly, the lobe‐shaped portions of the mouthparts do not express omb, indicating that these are ventral components and thus may be homologous to the endites present in the corresponding appendages in insects. Concerning the H15 gene we were able to identify two paralogous genes in Glomeris. Both genes are expressed in the sensory organs of the maxilla and antenna, but only Gm‐H15‐1 is expressed along the ventral side of the trunk legs. The expression is more extensive than in Cupiennius, but less so than in Drosophila. In addition, no ventral expression domain is present in the maxilla, mandible, and antenna. Because of this, the role of H15 in the determination of ventral fate remains unclear.
Three-gene prognostic classifier for early-stage non small-cell lung cancer.

PURPOSE Several microarray studies have reported gene expression signatures that classify non-small-cell lung carcinoma (NSCLC) patients into different prognostic groups. However, the prognostic gene lists reported to date overlap poorly across studies, and few have been validated independently using more quantitative assay methods. PATIENTS AND METHODS The expression of 158 putative prognostic genes identified in previous microarray studies was analyzed by reverse transcription quantitative polymerase chain reaction in the tumors of 147 NSCLC patients. Concordance indices and risk scores were used to identify a stage-independent set of genes that could classify patients with significantly different prognoses. RESULTS We have identified a three-gene classifier (STX1A, HIF1A, and CCR7) for overall survival (hazard ratio = 3.8; 95% CI, 1.7 to 8.2; P < .001). The classifier was also able to stratify stage I and II patients and further improved the predictive ability of clinical factors such as histology and tumor stage. The predictive value of this three-gene classifier was validated in two large independent microarray data sets from Harvard and Duke Universities. CONCLUSION We have identified a new three-gene classifier that is independent of and improves on stage to stratify early-stage NSCLC patients with significantly different prognoses. This classifier may be tested further for its potential value to improve the selection of resected NSCLC patients in adjuvant therapy.
Nutrient-Gene Interactions Dietary Fat Interacts with the 514 C > T Polymorphism in the Hepatic Lipase Gene Promoter on Plasma Lipid Profiles in a Multiethnic Asian Population : The 1998 Singapore National Health Survey 1 , 2

We have previously reported an interaction between 514C T polymorphism at the hepatic lipase (HL) gene and dietary fat on high-density lipoprotein-cholesterol (HDL-C) metabolism in a representative sample of white subjects participating in the Framingham Heart Study. Replication of these findings in other populations will provide proof for the relevance and consistency of this marker as a tool for risk assessment and more personalized cardiovascular disease prevention. Therefore, we examined this gene-nutrient interaction in a representative sample of Singaporeans (1324 Chinese, 471 Malays and 375 Asian Indians) whose dietary fat intake was recorded by a validated questionnaire. When no stratification by fat intake was considered, the T allele was associated with higher plasma HDL-C concentrations (P 0.001), higher triglyceride (TG) concentrations (P 0.001) and higher HDL-C/TG ratios (P 0.041). We found a highly significant interaction (P 0.001) between polymorphism and fat intake in determining TG concentration and the HDL-C/TG ratio (P 0.001) in the overall sample even after adjustment for potential confounders. Thus, TT subjects showed higher TG concentrations only when fat intake supplied 30% of total energy. This interaction was also found when fat intake was considered as continuous (P 0.035). Moreover, in the upper tertile of fat intake, TT subjects had 45% more TG than CC individuals (P 0.01). For HDL-C concentration, the gene-diet interaction was significant (P 0.015) only in subjects of Indian origin. In conclusion, our results indicate that there are differences in the association of 514C T polymorphism with plasma lipids according to dietary intake and ethnic background. Specifically, the TT genotype is associated with a more atherogenic lipid profile when subjects consume diets with a fat content 30%. J. Nutr. 133: 3399–3408,
Fast and slow rotators in the densest environments: a SWIFT IFS study of the Coma cluster

We present integral-field spectroscopy of 27 galaxies in the Coma cluster observed with the Oxford SWIFT spectrograph, exploring the kinematic morphology-density relationship in a cluster environment richer and denser than any in the ATLAS3D survey. Our new data enables comparison of the kinematic morphology relation in three very different clusters (Virgo, Coma and Abell 1689) as well as to the field/group environment. The Coma sample was selected to match the parent luminosity and ellipticity distributions of the early-type population within a radius 15' (0.43 Mpc) of the cluster centre, and is limited to r' = 16 mag (equivalent to M_K = -21.5 mag), sampling one third of that population. From analysis of the lambda-ellipticity diagram, we find 15+-6% of early-type galaxies are slow rotators; this is identical to the fraction found in the field and the average fraction in the Virgo cluster, based on the ATLAS3D data. It is also identical to the average fraction found recently in Abell 1689 by D'Eugenio et al. Thus it appears that the average slow rotator fraction of early type galaxies remains remarkably constant across many different environments, spanning five orders of magnitude in galaxy number density. However, within each cluster the slow rotators are generally found in regions of higher projected density, possibly as a result of mass segregation by dynamical friction. These results provide firm constraints on the mechanisms that produce early-type galaxies: they must maintain a fixed ratio between the number of fast rotators and slow rotators while also allowing the total early-type fraction to increase in clusters relative to the field. A complete survey of Coma, sampling hundreds rather than tens of galaxies, could probe a more representative volume of Coma and provide significantly stronger constraints, particularly on how the slow rotator fraction varies at larger radii.
Prevalence of carbapenem resistance genes in Acinetobacter baumannii isolated from clinical specimens obtained from an academic hospital in South Africa

Acinetobacter baumannii is an important cause of hospital-acquired infections. The occurrence of carbapenem resistance that is caused by the carbapenem-hydrolysing class D β-lactamases and the metallo-β-lactamases (MBLs) limits the range of therapeutic alternatives in treating A. baumannii infections. In this study, two multiplex polymerase chain reactions were performed to screen for both carbapenem-hydrolysing class D β-lactamases and MBL genes in 97 clinical isolates of A. baumannii. Oxacillinase (OXA)-51 had a prevalence of 83% (81/97), and OXA-23 had a prevalence of 59% (57/97). One isolate was positive for an MBL [Verona integron-encoded metallo β-lactamases (VIM)]. Therefore, continuous surveillance and monitoring of A. baumannii is crucial because of the high prevalence of antibiotic resistance genes.
Real-Time Spectrum Analysis in Microstrip Technology

We report on a time-domain analog to the spatial far-field Fraunhofer diffraction using microstrip lines with chirped distributed Bragg coupling between the fundamental microstrip mode and the same but counter-propagating mode. The chirping of the microstrip impedance yields to linear group delays within the reflected bandwidth. Under the condition of a temporal equivalent of the spatial Fraunhofer inequality, the distortion of a frequency-limited pulse results in an output reflected signal whose complex envelope is, except a phase factor, proportional to the Fourier Transform of the input pulse envelope. This has important temporal applications and, in particular, the devices designed in this paper work as real-time energy spectral density analyzers.
Convergence of Different Versions of the Continuous Performance Test: Clinical and Scientific Implications

The Continuous Performance Test has been used for the last 40 years to measure sustained attention or vigilance in many different populations. Different versions of the test have been developed, but little is known about how similar these tests are, and to what extent performance on different versions of these tests overlaps. In order to examine convergence of the different versions of the CPT, three different CPTs were administered in both the Auditory and Visual Sensory Modalities. Subjects were selected from consecutive admissions to adolescent acute care units at a private psychiatric hospital (n =100). Auditory test modalities uniformly elicited poorer performance than visual tests, while each set of task demands consistently elicited differences in performance. Despite the high test–retest reliability of the individual subtests, the average correlation between tests was r =. 42, with the average correlation between visual tests at r =. 48 and the average correlation between the auditory tests was r =. 45. The correlations within task demands across sensory modalities ranged from a low of . 37 to a high of . 52. Controlling for IQ did not influence the correlations to a substantial degree. These data suggest different versions of the CPT are correlated with each other at a level consistent with construct validity, but that they do not constitute alternate forms of the same test.
India : Towards Universal Health Coverage 4 Health care and equity in India

In India, despite improvements in access to health care, inequalities are related to socioeconomic status, geography, and gender, and are compounded by high out-of-pocket expenditures, with more than three-quarters of the increasing fi nancial burden of health care being met by households. Health-care expenditures exacerbate poverty, with about 39 million additional people falling into poverty every year as a result of such expenditures. We identify key challenges for the achievement of equity in service provision, and equity in fi nancing and fi nancial risk protection in India. These challenges include an imbalance in resource allocation, inadequate physical access to high-quality health services and human resources for health, high out-of-pocket health expenditures, infl ation in health spending, and behavioural factors that aff ect the demand for appropriate health care. Use of equity metrics in monitoring, assessment, and strategic planning; investment in development of a rigorous knowledge base of health-systems research; development of a refi ned equity-focused process of deliberative decision making in health reform; and redefi nition of the specifi c responsibilities and accountabilities of key actors are needed to try to achieve equity in health care in India. The implementation of these principles with strengthened public health and primary-care services will help to ensure a more equitable health care for India’s population.
A clinic-based interdisciplinary intervention for mothers of children newly diagnosed with cancer: a pilot study.

OBJECTIVE To determine the feasibility and acceptability of an interdisciplinary intervention for mothers of children newly diagnosed with cancer and to estimate effect sizes for the intervention in reducing distress. Management of illness uncertainty was a key framework for the intervention. METHODS Mothers (N = 52) were randomly assigned to the intervention or a treatment as usual group, completing measures at baseline and follow-up time points. RESULTS Mothers' satisfaction ratings were consistently high, and intervention implementation appeared feasible. Significant mean effects or trends in favor of the intervention group were found for pre-to-post change on measures of distress. Evidence of a preventative effect was also observed; mothers in the intervention group tended to improve or remain stable in their adjustment, whereas many parents in the treatment as usual group showed worsening outcomes. CONCLUSIONS An interdisciplinary intervention targeting maternal illness uncertainty has clinical value within this sample.
Caring behaviors as perceived by nurse practitioners.

PURPOSE To investigate nurse pratctitioners' (NPs') perceptions of their own caring behaviors and to examine NPs' demographics as a function of their caring behaviors. DATA SOURCES Responses to the Caring Behaviors Inventory(CBI) and a demographic inquiry from 348 NPs in Louisiana. CONCLUSIONS CBI mean scores and subscale scores were high for all 348 NPs. No statistically significant difference was found between male NPs' and female NPs' total mean CBI scores or between urban or rural total mean CBI scores. The interaction between nurse gender and area o practice was not statistically significant. IMPLICATIONS FOR PRACTICE NPs often work in clinic situations where productivity is the most valued characteristic and where little time is afforded for identifying caring behaviors of the NP and/or establishing a caring relationship with the patient. NPs must be extremely conscious of the need not to "throw out the baby with the bathwater" and sacrifice characteristics that are inherent in nursing for those emphasized in primary care practice. As their responsibilities in the health care setting continue to expand, NPs must continually evaluate and validate their roles to ensure quality care that satisfies patients.