Miracle-dz/UniFAR-FTUs huggingface dataset:
Examining the Relational Benefits of Improved Interfirm Information Processing Capability in Buyer-Supplier Dyads

Information Systems research has studied how buyers and suppliers can benefit from improved information visibility in supply chains characterized by uncertainty. However, the relation-specific information processing solutions that provide visibility can only be exploited if the two firms engage in sufficient coordination efforts. This work takes a nuanced look at how dyadic benefits are derived in the supply chain. Drawing on the information processing view, resource-based view, and transaction cost theory, this study explicates how buyer performance can result from buyer's use of relation-specific information processing solutions and supplier's relational responses. Two interfirm information processing solutions are proposed and examined: the use of IT-based systems for planning and control, and the use of relational (normative) contracts. Based on a sample of 144 manufacturing firms, eight of the nine proposed research hypotheses receive empirical support using PLS analysis. The findings suggest that as buyers and suppliers utilize the IT and relational solutions, they induce relation-specific responses represented as supplier's business process investments and modification flexibility, which in turn lead to positive buyer outcomes. The results help us gain a more granular understanding on how relation-specific interfirm information processing solutions can lead to performance through enhanced interfirm governance capabilities.
Epidermal growth factor receptor tyrosine kinase inhibitors in elderly patients with non-small cell lung cancer

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. At diagnosis, half of the patients are over 70 years of age, and most present with advanced disease, for which chemotherapy is recommended as first-line treatment. However, the benefit from such therapy is modest and it is at times poorly tolerated. The discovery of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has significantly impacted the treatment of patients with EGFR mutation-positive advanced NSCLC. These novel agents demonstrate efficacy and a favorably mild toxicity profile. Despite limited data in elderly patients, the largest subpopulation in NSCLC, EGFR-TKIs are considered the standard of care therapy for advanced EGFR-positive disease in the elderly. In this review, we seek to compile the available data about the EGFR-TKIs use in elderly patients with advanced NSCLC, with the hope to better understand its role in this major yet, underrepresented, group of patients.
The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology

Mitochondria are major sources of reactive oxygen species (ROS); the main sites of superoxide radical production in the respiratory chain are Complexes III and I; however, other mitochondrial enzymes, such as Complex II, glycerol‐1‐phosphate dehydrogenase, and dihydroorotate dehydrogenase, are also involved in production of ROS. ROS appear to be released both in the matrix and in the intermembrane space; however, their appearance outside the mitochondria may not be physiologically relevant. ROS production is increased in State 4 and in all conditions when the respiratory components are substantially in the reduced form. Accordingly, defects inducing decrease of electron transfer in the respiratory chain, as in many pathological conditions, are bound to enhance ROS production.
Type and Timing of Mothers' Victimization: Effects on Mothers and Children

Objectives. There is mounting concern about how mothers' own victimization experiences affect their children. This study examines the effects of mothers' victimization on their own mental health and parenting and on their children's behavior, development, and health. The effects of both timing and type of victimization are assessed. A related objective was to determine if there was a cumulative risk effect produced by victimization during both childhood and adulthood, or both physical and sexual. Setting. Urban families in an eastern state and urban and rural families in a southern state. Participants. A total of 419 mothers and their children 6 to 7 years old were identified from 2 sites. The eastern sample was recruited in the first 2 years of life from 3 pediatric clinics: 1 for children at high risk for human immunodeficiency virus disease, 1 for children with failure to thrive, and a third providing pediatric primary care. The southern sample was derived from a cohort of children at risk for adverse health or developmental outcomes, plus a systematic sampling of controls, recruited from area hospitals. At age 4, a random sample of children from the original cohort who had been maltreated along with a matched comparison group of nonmaltreated children were selected. Results. In general, mothers victimized during both childhood and adulthood had poorer outcomes than mothers victimized during either childhood/adolescence or adulthood who in turn had worse outcomes than mothers with no history of victimization. This manifested as more maternal depressive symptoms, harsher parenting, and more externalizing and internalizing behavior problems in their children. There were no significant differences in maternal functioning or child outcomes between those abused in childhood and those abused in adulthood. These findings were similar for type of victimization. Mothers' depression and harsh parenting were directly associated with their children's internalizing and externalizing behavior problems. Conclusions. Maternal victimization appears to be a highly prevalent problem in high-risk samples and is associated with harmful implications for mental health and parenting, as well as for the offspring. Pediatricians need to consider past and current victimization of mothers. Routine screening for these problems, followed by appropriate evaluation and intervention may reduce maternal depression, improve parenting, and reduce the incidence of behavior problems in children.
EPIDEMIOLOGIC STUDY OF MULTIPLE SCLEROSIS IN ISRAEL. I. AN OVERALL REVIEW OF METHODS AND FINDINGS.

THE FREQUENCY of multiple sclerosis increases with latitude both in the northern 1-15 and southern hemisphere. 16,17 Ethnic differences apparently do not account for this peculiar distribution, as the disease occurs with essentially the same frequency among different ethnic groups born in the same region. 12-14 On the basis of these observations, it has been suggested that an environmental factor correlated with latitude may play an etiologic role in multiple sclerosis. 1,2,11,14,18-22 Numerous factors known to vary with latitude have been suggested as possible etiologic agents including sunlight, 11,12,16,19,20 temperature, 1,19,20 humidity, 19,23 and diet. 24-28 If an environmental factor is, indeed, of importance in etiology, it would be expected that populations with a high frequency of the disease would have greater exposure to the factor(s) than populations with low frequency. Moreover, within each population, patients with multiple sclerosis might have had a higher frequency of exposure to the
Visual Function Changes After Punctal Occlusion With the Treatment of Short BUT Type of Dry Eye

Purpose To evaluate visual function changes after punctal plug (PP) occlusion in patients with short breakup time of tear film (BUT) type of dry eyes. Methods A prospective comparative study was performed in 43 eyes of 43 dry eye patients with short BUTbreakup time of tear film receiving PP occlusion. Patients were divided into 2 groups as those receiving only upper or only lower occlusion. Functional visual acuity measurements, tear function evaluations, and questionnaire on satisfaction with treatment in relation to presence of epiphora were performed before and 1 month after PP insertion. Results Twenty eyes of 43 eyes (46.5%) with only lower occlusion and 17 eyes of 43 eyes (39.5%) with only upper occlusion showed satisfactory outcomes with treatment. One of 43 eyes (2.3 %) had epiphora. Vital staining scores and BUT values significantly improved in both groups after occlusion. The mean logarithm of the minimum angle of resolution functional visual acuity value significantly improved only in eyes receiving upper PP occlusion. Conclusion Upper PP occlusion seems to be associated not only with improvement of tear stability, vital staining scores, and treatment-related satisfaction but also with better quality of visual function.
In vivo binding of wild-type and mutant human immunodeficiency virus type 1 Rev proteins: implications for function

The Rev transactivator protein of human immunodeficiency virus type 1 (HIV-1) is required for protein expression from the HIV-1 RNAs which contain a binding site for the Rev protein, termed the Rev-responsive element (RRE). This transactivator acts both at the level of splicing/transport of nuclear RNAs and at the level of translation of cytoplasmic RNAs. We used a monoclonal antibody specific for the HIV-1 Rev protein to immunoprecipitate cellular extracts from HIV-1-infected and -transfected cells. High levels of specific binding of wild-type Rev to the RRE-containing RNAs were found in cytoplasmic, but not nuclear, extracts from these cells. A Rev mutant which lacked both nuclear and cytoplasmic Rev function but retained RNA binding in vivo was generated. This binding was detectable with both nuclear and cytoplasmic extracts. These results verify the existence of direct binding of Rev to HIV-1 RNAs in vivo and conclusively prove that binding of Rev is not sufficient for nuclear or cytoplasmic Rev function. The results also support a direct role for Rev in the nuclear export and translation of HIV-1 RNAs.
Effects of Rapamycin on Active Heymann Nephritis

Background/Aim: The effects of rapamycin (RAPA) were examined in active Heymann nephritis (HN), an experimental model of human membranous nephropathy (MN). Current opinion on the therapy of MN is controversial, and medications used for its treatment have not yielded the expected results. Methods: In a two-part study, we examined the effects of RAPA (1.5 mg/kg/day) during the induction phase of HN and on the evolving disease. In both parts, control groups of immunized rats not treated with RAPA and control groups of unimmunized rats were observed and sacrificed concurrently with the treated groups. Results: During the induction phase no significant changes in proteinuria were observed in the group treated with RAPA, in comparison to those in the untreated group (p < 0.001). During the evolving disease RAPA significantly lowered proteinuria (p < 0.001). The characteristic pathohistologic changes and IgG depositions along the glomerular basement membrane were considerably diminished, and infiltration of CD8+ cells completely prevented. Conclusion: RAPA demonstrated beneficial effects on disease progression, given either in the induction phase or during evolving HN. It would be desirable to investigate the effect of RAPA on patients with MN.
[Chemical constituents of Fortunella margarita fruits].

OBJECTIVE To study the chemical constituents of the fruits of Fortunella margarita. METHODS The constituents were isolated and purified on silica gel column and other column chromatography, and their structures were determined by means of spectral techniques and physicochemical data. RESULTS 11 compounds were isolated and identified as fortunellin (1), naringenin (2), phloridzin (3), nicotinflorin (4), rhoifolin (5), 4'-methoxy vitexin-2"-O-alpha-L-rhamnopyranoside (6), 4'-methoxy isovitexin-2"-O-alpha-L-rhamnopyranoside (7), rutin (8), phloretin-3', 5'-di-C-beta-glucopyranoside (9), 5-hydroxymethyl-furaldehyde (10) and beta-sitosterol (11). CONCLUSION Compound 2 - 4,7 and 10 are isolated from the plant for the first time.
Diagnostic accuracy of atypical p-ANCA in autoimmune hepatitis using ROC- and multivariate regression analysis.

INTRODUCTION Antineutrophil cytoplasmic antibodies (atypical p-ANCA) are detected at high prevalence in sera from patients with autoimmune hepatitis (AIH), but their diagnostic relevance for AIH has not been systematically evaluated so far. METHODS Here, we studied sera from 357 patients with autoimmune (autoimmune hepatitis n=175, primary sclerosing cholangitis (PSC) n=35, primary biliary cirrhosis n=45), non-autoimmune chronic liver disease (alcoholic liver cirrhosis n=62; chronic hepatitis C virus infection (HCV) n=21) or healthy controls (n=19) for the presence of various non-organ specific autoantibodies. Atypical p-ANCA, antinuclear antibodies (ANA), antibodies against smooth muscles (SMA), antibodies against liver/kidney microsomes (anti-Lkm1) and antimitochondrial antibodies (AMA) were detected by indirect immunofluorescence microscopy, antibodies against the M2 antigen (anti-M2), antibodies against soluble liver antigen (anti-SLA/LP) and anti-Lkm1 by using enzyme linked immunosorbent assays. To define the diagnostic precision of the autoantibodies, results of autoantibody testing were analyzed by receiver operating characteristics (ROC) and forward conditional logistic regression analysis. RESULTS Atypical p-ANCA were detected at high prevalence in sera from patients with AIH (81%) and PSC (94%). ROC- and logistic regression analysis revealed atypical p-ANCA and SMA, but not ANA as significant diagnostic seromarkers for AIH (atypical p-ANCA: AUC 0.754+/-0.026, odds ratio [OR] 3.4; SMA: 0.652+/-0.028, OR 4.1). Atypical p-ANCA also emerged as the only diagnostically relevant seromarker for PSC (AUC 0.690+/-0.04, OR 3.4). None of the tested antibodies yielded a significant diagnostic accuracy for patients with alcoholic liver cirrhosis, HCV or healthy controls. CONCLUSIONS Atypical p-ANCA along with SMA represent a seromarker with high diagnostic accuracy for AIH and should be explicitly considered in a revised version of the diagnostic score for AIH.
Why Do People Reject Unintended Inequity? Responders' Rejection in a Truncated Ultimatum Game

Rejection of an inequitable and yet unintended outcome in a truncated ultimatum game was examined in an experiment with 46 undergraduate students (27 men and 19 women) from a large national university in Japan. In an ultimatum game, one of two players, the proposer, makes an offer to divide a fixed-sum of money. The other player, the responder, decides whether to accept or reject the offer. When the responder rejects the proposer's offer, neither of the two players receives a reward. Previous work examining the behavior of participants in the truncated ultimatum game employed strategy method in their experimental design. We examined whether these previous findings would be replicated in an experimental design that did not use the strategy method and instead used the standard one-shot game. Seven out of 46 responders given an inequitable offer rejected it, replicating prior results with the strategy method. We further found that subjects who rejected an offer that was involuntary and yet inequitable did not over-attribute intentions to the proposer's involuntary behavior more strongly than did acceptors. These findings strongly suggest that aversion to inequity is the explanation for the subjects' rejection of the inequitable offer.
A Compact Balanced-to-Balanced Filtering Gysel Power Divider Using $\lambda _{g}$ /2 Resonators and Short-Stub-Loaded Resonator

In this letter, a compact balanced-to-balanced filtering power divider (FPD) is presented. It is composed of three half-wavelength resonators and a short-stub-loaded resonator (SSLR). Due to the intrinsic resonance characteristic of the half-wavelength resonator, the bandpass response and power dividing function for differential-mode signal are realized and the suppression for common-mode signal is also achieved. The SSLR is utilized as an extra isolation resonator to achieve high isolation between two output ports. A resister is also needed to load on the SSLR for adjusting its loaded quality factor $(Q_{e})$ . For the demonstration of the design method, an FPD operating at 2.405 GHz has been fabricated and measured. The measured results validate the design method.
Contrasting responses by basal ganglia met‐enkephalin systems to low and high doses of methamphetamine in a rat model

The influence of methamphetamine (METH) on basal ganglia met‐enkephalin (Menk) was studied by determining levels of this peptide in striatal, pallidal and nigral regions after administering a single low (0.5 mg/kg) or high (10 mg/kg) dose of this stimulant. The Menk levels in the striatal and pallidal areas were reduced and increased after the low‐ and high‐dose METH treatments, respectively, 12 h after drug administration in all striatal and pallidal regions examined. The low‐dose effect appeared to be principally influenced by increased activation of the dopamine D2‐like receptor, while the high‐dose effect seemed to result from dominance of D1‐like receptor activation. However, both effects required coactivation of D1‐ and D2‐like receptors. For the most part, both low‐ and high‐dose METH‐induced changes in Menk tissue content were fully recovered by 24 h. The Menk levels were not significantly altered in the substantia nigra 3–24 h after either METH treatment. Results reported herein indicated that striatal and pallidal Menk pathways respond differently after acute treatment with low or high doses of METH.
Premature cardiovascular mortality in France: divergent evolution between social categories from 1970 to 1990.

BACKGROUND In France, differences in cardiovascular risk factor distribution have been observed which might be responsible for some disparities in cardiovascular mortality between social categories. The goal of the study was thus to assess the differences in coronary heart disease (CHD) and cerebrovascular diseases (CVD) mortality according to social category, and to determine their trends over the last 20 years in France. METHODS Mortality data for CHD, CVD, diseases of the circulatory system (CS) and all causes mortality (TM) were based on death certificates for 1970, 1980 and 1990, and categorized by sex, age group (35-44 and 45-54 years), region and social category. RESULTS Among active men, from 1970 to 1990, the overall decrease observed for all causes of death was significantly slower among employees and workers for CHD, CS and TM (P < 0.001), but not for CVD. In 1990, the highest mortality rates were observed among employees and workers for CHD, CVD and CS mortality. In women, no such trend was observed for CHD, CVD or CS mortality. No statistically significant difference between social categories was observed in 1990 for CHD and CVD. In the whole active population, a negative trend for the mortality rates was observed between 1970 and 1990 whatever the cause in both sexes. The ratio between mortality rates among non-active versus active people increased during the two decades in both sexes. CONCLUSIONS In men, the inequalities have increased over the last two decades for CHD and have not been reduced for CVD. The category of employees and workers were found to be at special risk for premature cardiovascular disease mortality. Among women, the trends were less clear, although the tendencies were the same. An increasing disparity between active and non-active people suggests that a health-related selection process towards unemployment might have contributed to the decreasing mortality rates observed among employees and workers.
Hepatocyte growth factor stimulates fetal gastric epithelial cell growth in vitro.

BACKGROUND The growth and development of the fetal gastrointestinal tract is likely mediated, in part, by peptide growth factors. We compared the mitogenic effects of graded doses of hepatocyte growth factor (HGF) to epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), and insulin-like growth factor-1 (IGF-1) on fetal rabbit gastric epithelial cells. MATERIALS AND METHODS Fetal rabbit gastric epithelial cells were purified by mechanical dissociation and selected culture and grown in short-term (24 h) and long-term (12 days) culture. Stimulation of fetal gastric epithelial cell growth in response to individual peptide growth factors was measured by [3H]thymidine incorporation and cell counting. RESULTS In short-term culture, HGF stimulated [3H]thymidine incorporation in a dose-dependent manner from a threshold at 10 pM to a maximum at 100 pM. For EGF and TGF-alpha, maximal stimulation occurred at 100 pM. For HGF, maximal [3H]thymidine incorporation was 3.6 +/- 0.7 times basal. For EGF and TGF-alpha, maximal [3H]thymidine incorporation was 4.3 +/- 0.4, and 3.6 +/- 0.4 times basal, respectively. For IGF-1, maximal [3H]thymidine incorporation was only 70% of the maximal effect observed for the other growth factors tested. Rabbit amniotic fluid increased [3H]thymidine uptake in a dose-dependent manner. In long-term culture, purification to greater than 90% epithelial cells was attained after 12 days treatment. For HGF, EGF, TGF-alpha, and 20% rabbit amniotic fluid, significant increases in cell number above control (P < 0.05) were observed at 1 nM concentrations. None of these individual factors, however, increased cell growth as significantly as that of 10% fetal bovine serum. CONCLUSIONS Our results suggest that: (1) HGF stimulates [3H]thymidine uptake and cell proliferation in fetal rabbit gastric epithelial cells in vitro, and (2) HGF's mitogenic effect on fetal rabbit gastric epithelial cell growth is comparable to that observed for EGF and TGF-alpha, but superior to the effect observed for IGF-1.
In the Shadow of Banks: Wealth Management Products and Issuing Banks' Risks in China

We study the rise and risks in bank issuance of Wealth Management Products (WMPs), which are off-balance-sheet substitutes for deposits without the regulatory interest rate ceilings and constitute the largest shadow banking segment in China. We show that competition for deposits has a causal effect on the WMP issuance of small and medium sized banks (SMBs), where we instrument deposit competition by SMBs' geographical exposure to the large (Big Four) banks. The Big Four banks substantially increased their loan supply to support the RMB 4 trillion stimulus initiated in response to the global financial crisis, and thereafter grew more aggressive in the deposit markets in order to stay below the regulatory ceiling on the loan-to-deposit ratio. In response, SMBs issued more WMPs and more frequently, besides also establishing fewer branches in cities with greater competition from the Big Four banks. We find that this growth of WMPs imposed rollover risks for all the bank issuers, as reflected in higher yields on new WMPs, higher borrowing rates in the inter-bank market, and adverse stock market performance of WMP-issuing banks on days with heightened rollover risks.
Sudden death from cardiac causes in children and young adults.

Although sudden death in a young person is rare, it can have a great impact on both the lay and the medical communities. Such unanticipated deaths sometimes occur in dramatic circumstances and often have medical and legal ramifications. Some of these deaths are not predictable or preventable by current practical means; however, in many cases there are premonitory symptoms, a family history of sudden death at a young age, clinical or electrocardiographic abnormalities, or high-risk behavior. Among older adults, sudden deaths are often due to atherosclerotic coronary artery disease and terminal ventricular fibrillation. Each year there are 300,000 such deaths .