Miracle-dz/UniFAR-FTUs huggingface dataset:
Customer Knowledge Management

As companies begin to develop competence in managing internal knowledge and applying it towards achieving organizational goals, they are setting their sights on new sources of knowledge that are not necessarily found within the boundaries of the firm. Customer knowledge management comprises the processes that are concerned with the identification, acquisition, and utilization of knowledge from beyond a firm’s external boundary in order to create value for an organization. Companies can utilize this knowledge in many different forms of organizational improvement and change, but it is especially valuable for innovation and the new product development function. The notion of working with partners to share information was first discussed in 1966 where the possibility of transferring information between a company and its suppliers and customers was identified. Kaufman (1966) describes the advantages to a business that include reduced order costs, reduced delivery time, and increased customer “confidence and goodwill” (p. 148). Organizations have since been viewed as interpretation systems that must find ways of knowing their environment (Daft & Weick, 1984). Through this environmental learning, a firm’s ability to innovate can improve by going beyond a firm’s boundaries to expand the knowledge available for creating new and successful products. Some organizations conduct ongoing, active searches of the environment to seek new and vital information. Such organizations become the key innovators within an industry. Other, more passive organizations accept whatever information the environment presents and avoid the processes of testing new ideas and innovation. Marketing literature refers to this concept as market orientation (Kohli & Jaworski, 1990; Slater & Narver, 1995). More recently, many organizations have realized the value of information about their customers through customer relationship management and data mining strategies, and have used this information to tailor their marketing efforts (Berson, Smith, & Thearling, 2003; Blattberg, Getz, &
Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study

Abstract Solid lipid nanoparticles (SLNs) are very potential formulations for topical delivery of antifungal drugs. Hence, the purpose of this research was to formulate the well-known antifungal agent Fluconazole (FLZ)-loaded SLNs topical gel to improve its efficiency for treatment of Pityriasis Versicolor (PV). FLZ-SLNs were prepared by modified high shear homogenization and ultrasonication method using different concentration of solid lipid (Compritol 888 ATO, Precirol ATO5) and surfactant (Cremophor RH40, Poloxamer 407). The physicochemical properties and the in vitro release study for all FLZ-SLNs were investigated. Furthermore, the optimized FLZ-SLN formula was incorporated into gel using Carpobol 934. A randomized controlled clinical trial (RCT) of potential batches was carried out on 30 well diagnosed PV patients comparing to market product Candistan® 1% cream. Follow up was done for 4 weeks by clinical and KOH examinations. The results showed that FlZ-SLNs were almost spherical shape having colloidal sizes with no aggregation. The drug entrapment efficiency ranged from 55.49% to 83.04%. The zeta potential values lie between −21 and −33 mV presenting good stability. FLZ showed prolonged in vitro release from SLNs dispersion and its Carbapol gel following Higuchi order equation. Clinical studies registered significant improvement (p < .05) in therapeutic response (1.4-fold; healing%, 4-fold; complete eradication) in terms of clinical cure and mycological cure rate from PV against marketed cream. Findings of the study suggest that the developed FLZ loaded SLNs topical gels have superior significant fast therapeutic index in treatment of PV over commercially available Candistan® cream.
Text Classification through Statistical and Machine Learning Methods: A Survey

_________________________________ Abstract - With the instant growth of information, text classification has become a vital technique for handling and organizing text data. In general, Text classification plays an important role in information extraction, text summarization text retrieval, medical diagnosis, news group filtering, spam filtering, and sentiment analysis. This paper illustrates the text classification process using machine learning techniques and statistical techniques such as k-nearest neighbors, support vector machine, naive Bayesian method.
Anticoagulation and kidney injury: rare observation or common problem?

Vitamin K antagonists (VKAs), which inhibit the synthesis of the coagulation factors II, VII, IX and X, have been in clini- cal use since the 1950s to treat thrombotic disease. Re- cently, new indications for long-term anticoagulation have been recognised. Consequently the number of patients prescribed long-term anticoagulant therapy with VKAs is in- creasing. Warfarin is the most commonly prescribed VKA, but acenocoumarol and phenprocoumon are also widely used in Europe. Patients with chronic kidney disease (CKD) are at a relatively higher risk of thromboembolic disease. In addition, patients on long-term warfarin often have mul- tiple comorbidities placing them at risk of kidney disease. Therefore, warfarin is a commonly used drug in CKD patients. There are obvious dangers of overanticoagulation, most im- portantly the risk of haemorrhage, a complication which is twofold more common in patients with CKD (1). Maintaining warfarin within its narrow therapeutic range can be more dif- ficult in patients with CKD, and overt, hypovolaemic blood loss resulting from overanticoagulation can precipitate acute kidney injury (AKI). However, warfarin use alone was not tra- ditionally thought of as a cause of kidney injury.
Mesenchymal Stem Cells and Potential Applications in Treating Ocular Disease

Mesenchymal stem cells (MSCs) are remarkable in stem cell biology. Not only do they have significant tissue regeneration potential, but more recently their paracrine effects (either innate or through genetic augmentation) have become increasingly recognized as useful therapeutic approaches. In particular, clinical roles for MSC therapy in neuroprotection and immune suppression are likely to emerge. These therapeutic effects will be particularly advantageous in work on neurological tissues, because MSC-based molecular therapy could overcome some of the difficulties of long-term drug delivery to tissues, such as the eye, which are relatively inaccessible to systemic delivery (for example due to the blood retina barrier). MSC therapy is, therefore, poised for significant impact in ocular molecular therapeutics, particularly for chronic diseases, such as retinal degeneration, glaucoma, and uveitis. Other molecular and tissue regeneration effects of MSCs are also likely to have impact in the management of ocular surface disease and oculoplastics.
The spatial frequencies influence the aesthetic judgment of buildings transculturally

Recent evidence has shown that buildings designed to be high-ranking, according to the Western architectural decorum, have more impact on the minds of their beholders than low-ranking buildings. Here we investigated whether and how the aesthetic judgment for high- and low-ranking buildings was affected by differences in cultural expertise and by power spectrum differences. A group of Italian and Japanese participants performed aesthetic judgment tasks, with line drawings of high- and low-ranking buildings and with their random-phase versions (an image with the exact power spectrum of the original one but non-recognizable anymore). Irrespective of cultural expertise, high-ranking buildings and their relative random-phase versions received higher aesthetic judgments than low-ranking buildings and their random-phase versions. These findings indicate that high- and low-ranking buildings are differentiated for their aesthetic value and they show that low-level visual processes influence the aesthetic judgment based on differences in the stimuli power spectrum, irrespective of the influence of cultural expertise.
Carnitine in Type 2 Diabetes

Abstract: Carnitine, the l‐β‐hydroxy‐γ‐N‐trimethylaminobutyric acid, is synthesized primarily in the liver and kidneys from lysine and methionine. Carnitine covers an important role in lipid metabolism, acting as an obligatory cofactor for β‐oxidation of fatty acids by facilitating the transport of long‐chain fatty acids across the mitochondrial membrane as acylcarnitine esters. Furthermore, since carnitine behaves as a shuttle for acetyl groups from inside to outside the mitochondrial membrane, it covers also a key role in glucose metabolism and assists in fuel‐sensing. A reduction of the fatty acid transport inside the mitochondria results in the cytosolic accumulation of triglycerides, which is implicated in the pathogenesis of insulin resistance. Acute hypercarnitinemia stimulates nonoxidative glucose disposal during euglycemic hyperinsulinemic clamp in healthy volunteers. Similar results were obtained in type 2 diabetic patients. The above findings were confirmed in healthy volunteers using the minimal modeling of glucose kinetics. The total end‐clamp glucose tissue uptake was significantly increased by the administration of doses of acetyl‐l‐carnitine (ALC) from 3.8 to 5.2 mg/kg/min, without a significant dose‐response effect. In conclusion, both l‐carnitine and ALC are effective in improving insulin‐mediated glucose disposal either in healthy subjects or in type 2 diabetic patients. Two possible mechanisms might be invoked in the metabolic effect of carnitine and its derivative: the first is a regulation of acetyl and acyl cellular trafficking for correctly meeting the energy demand; the second is a control action in the synthesis of key glycolytic and gluconeogenic enzymes.
Course of Fatigue Between Two Cycles of Adjuvant Chemotherapy in Breast Cancer Patients

The purpose of this study was to determine the course of fatigue in patients with breast cancer between 2 cycles of adjuvant chemotherapy, from the day of administration until the day of the next infusion. In a prospective cohort study, a sample of 151 patients with breast cancer receiving adjuvant chemotherapy was recruited from 6 hospitals in mainly the south of the Netherlands. Patients reported their experience of fatigue in a diary, the Shortened Fatigue Questionnaire, on a daily basis between the third and fourth treatment with adjuvant chemotherapy. Patients were treated with either a doxorubicin containing schedule or with cyclophosphamide, methotrexate, and 5-fluorouracil (CMF, 28 days). In the 28-day regimens, infusions were given on day 1 and day 8. The days after completion of the third and the start of the fourth treatment with chemotherapy were statistically analyzed. We tested the hypothesis that the maximum fatigue score occurs in the first 4 days after treatment. The mean age of the sample was 47.2 years (SD = 8.8). Most women (84%) were married or lived together with a partner. The majority (80%) of all patients had been diagnosed with stage II breast cancer. The division between mastectomies (47%) and lumpectomies (52%) was approximately equal. Sixty percent of the patients received radiotherapy before the third treatment with chemotherapy and/or in the period they kept the diary. A chaotic pattern of fatigue between the 2 cycles of chemotherapy emerged. Smooth (splines) curves showed an average highest level of fatigue on day 3 from the start. For the 28-day regimens, another distinct peak was seen around day 11. A relatively larger number of patients experienced peak fatigue levels before day 5. The course of fatigue in the CMF group was significantly different compared with the doxorubicin regimens. The fatigue peak in the CMF group was lower. Women taking cyclophosphamide orally experienced the peak level of fatigue significantly later. Influences of other variables were not observed in any chemotherapy group. Cancer-related fatigue has a chaotic nature. The first days after treatment with chemotherapy are the worst. The type of chemotherapy has a significant impact on the course of fatigue. Improved understanding of the nature and course of fatigue could equip healthcare providers better for informing patients about what they may expect. Future research should include interventions aimed at reducing or coping with fatigue.
Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study).

AIM to evaluate the effect of alpha-lipoic acid in autonomic diabetic neuropathy in a controlled, randomized, open-label study. MATERIAL AND METHODS 46 patients with type 1 diabetes and different forms of autonomic neuropathy, of mean age 38.1 +/- 12.5 years and mean duration of diabetes 16.8 +/- 8.9 years were treated with alpha-lipoic acid for 10 days 600mg daily iv, thereafter one film tablet of 600mg daily for 50 days. 29 type 1 diabetic patients with autonomic diabetic neuropathy, of mean age 40.2 +/- 9.3 years and mean duration of diabetes 15.4 +/- 7.9 years served as a control group. We have followed-up patients' complaints, Ewing's tests, laboratory parameters of oxidative stress. RESULTS There was a significant improvement after treatment in the score for severity of cardiovascular autonomic neuropathy--from 6.43 +/- 0.9 to 4.24 +/- 1.8 (p<0.001), while in the control group it worsened from 6.18 +/- 1.3 to 6.52 +/- 0.9 (p>0.1). We found improvement in the Valsalva manoeuvre after treatment - from 1.05 +/- 0.04 to 1.13 +/- 0.08 (p<0.001); in the deep-breathing test -from 3.4 +/- 2.8 to 10.4 +/- 5.7 (p<0.001); and in the lying-to-standing test--from 0.99 +/- 0.01 to 1.01 +/- 0.02 (p>0.1), while in the control group there was no improvement. There was a beneficial effect of treatment on the change of systolic blood pressure at the lying-to-standing test--from 22.7 +/- 11.5 to 9.8 +/- 7.9 (p<0.001), while in the control group the change was 20.5 +/- 11.1 mmHg and 19.7 +/- 12.9 mmHg (p>0.1), respectively. We found improvement in diabetic enteropathy in six patients; in the complaints of dizziness, instability upon standing in six patients; in neuropathic edema of the lower extremities in four patients and in erectile dysfunction in four patients after treatment, while in the control group no change was reported in the symptoms and signs of autonomic neuropathy by the end of the follow-up period. There were changes in the laboratory parameters of oxidative stress after therapy--total serum antioxidant capacity increased from 20.42 +/- 1.8 to 22.96 +/- 2.3 microgH2O2/ml/min (p<0.05), serum SOD activity - from 269.8 +/- 31.1 to 319.8 +/- 29.IU/l (p=0.02) and erythrocyte SOD--from 0.89 +/- 0.10 to 1.11 +/- 0.09 U/gHb (p=0.04). CONCLUSION Our results demonstrate that alpha-lipoic acid (Thiogamma) appears to be an effective drug in the treatment of the different forms of autonomic diabetic neuropathy.
Causes of corneal blindness: a multi-center retrospective review.

OBJECTIVE To assess prevalence and causes of corneal blindness in four hospitals in Thailand and to compare the causes between hospitals. MATERIAL AND METHOD A retrospective chart review of six hundred and sixty four patients records with best-corrected visual acuity not better than 6/60 in at least one eye due to corneal disease in Siriraj, Mettapracharak, Sappasitthiprasong and Banmee Hospitals in a one-year period were reviewed. The collected data included age, sex, laterality, causes of corneal blindness, and prognosis. RESULTS Seven hundred and sixty nine eyes with corneal blindness and a median age of 55.0 years were reviewed Leading causes of cornea blindness were corneal infection (35.6%), surgical bullous keratopathy (27.8%), and trauma (14.0%). The prevalence at Siriraj Hospital was 1.7% (498/28,728 patients). Most of the treatable cases (84.6%) underwent penetrating keratoplasty procedures and 73% of patients had a chance of recovery. CONCLUSION Corneal infection and surgical bullous keratopathy were the leading causes of corneal blindness.
Cystic lesions of the pancreas: current trends in approach and management

The more frequent deployment of cross-sectional imaging for various abdominal conditions has resulted in an increased detection of cystic pancreatic lesions, particularly cystic pancreatic neoplasms. Cystic pancreatic lesions may be neoplastic or non-neoplastic. They may appear radiologically similar and often present a diagnostic dilemma; they need to be diagnosed and differentiated with accuracy in order to offer optimum treatment. Some of the cystic neoplasms are potentially malignant and have a wide spectrum of histological variation from the frankly benign ‘adenomas’ to invasive adenocarcinomas . When identified, these cystic lesions need a systematic work up and a diagnostic algorithm should be followed to its logical conclusion. This article reviews these cystic lesions of the pancreas, neoplastic and pseudocysts, and aims to update readers with the current trends in their diagnosis and management.
Psychological Hardiness and Avoidance Coping Are Related to Risky Alcohol Use in Returning Combat Veterans

This study examines psychological hardiness and avoidance coping as predictors of risk for alcohol abuse in military personnel following war-zone deployment. U.S. Army soldiers returning from Afghanistan completed questionnaire surveys during their first week home, and again seven to nine months later. The Time 1 survey was administered in paper form during soldier administrative processing to home station. The Time 2 follow-up survey was administered electronically over the Internet. Data were analyzed using blockwise sequential logistic regressions, with age, rank, and combat exposure entered as covariates. Results show that low psychological hardiness, more combat exposure, younger age, and lower rank are associated with increased risk of alcohol abuse soon after return from deployment. At follow-up, avoidance coping was a significant predictor of risky alcohol use. These results suggest that alcohol screening programs for returning veterans may be improved by including assessment of such psychological variables as hardiness and avoidance coping.
HDL quality and functionality: what can proteins and genes predict?

Epidemiological and clinical studies have over the years established that dyslipidemia constitutes the main risk factor for atherosclerosis. The inverse correlation between HDL cholesterol (HDL-C) levels and coronary heart disease morbidity and mortality identified HDL-C as an alternative pharmacological target to LDL-C and a potential anti-atherosclerosis marker. However, more recent data reinforced the principle of ‘HDL quality’ in atherosclerosis that refers to the functionality of HDL particle, as defined by its protein and lipid content, rather than HDL-C levels in plasma. Since HDL functionality depends on the genes and proteins of the HDL metabolic pathway, its apoprotein composition may serve as a surrogate marker of atheroprotection. In this manuscript we review the atheroprotective properties of HDL in relation to the proteins of HDL metabolic pathway and discuss what HDL-associated genes and proteins may reveal about HDL functionality in the assessment of coronary risk.
Peripartum changes in gastric emptying

Applied potential tomography was ilsed to measure changes in gastric emptying during the peripartum period. Gastric emptying was measured sequentially in each of 10 healthy patients at 37–40 weeks gestation, 2–3 days postpartum and after the 6‐week postnatal assessment (control),‘Aean (SD) times to 50% emptying were 15 (6.05), 11 (5.9) and 15 (5.5) min, respectively. There was no statistically signijicant change in gastric emptying as a result of pregnancy in this group of women. Retrospective power analysis (assuming α= 0.05 and β= 0.20) shows the study design was adequate to detect a difference of 8 min.
Reduced Serum Phosphorus Levels Were Associated with Metabolic Syndrome in Men But Not in Women: A Cross-Sectional Study among the Japanese Population

Background: Reduced serum phosphorus (SP) levels are reported to be associated with insulin resistance and metabolic syndrome (MetS). However, there have been a few gender-specific studies although SP levels are substantially different between men and women. Methods: This is a cross-sectional study. A total of 16,041 subjects (9,076 men and 6,965 women) were analyzed. The subjects were divided into 3 groups of gender-specific tertiles based on phosphorus levels: the lowest (T1), middle (T2), and the highest (T3). Results: SP levels were significantly lower in subjects with MetS than in those without MetS in men but not in women. Waist circumference and fasting plasma glucose were negatively and high-density lipoprotein cholesterol was positively correlated with SP levels both in men and women. Blood pressure (BP) and triglycerides (TG) were negatively correlated with SP levels in men, while they were positively correlated with SP levels in women. Lower SP levels were associated with the prevalence of MetS in men (T1; 19.9%, T2; 16.9%, and T3; 14.3%; p < 0.001) but not in women (T1; 14.1%, T2; 16.6%, and T3; 15.3%; p = 0.282). Conclusion: BP and TG were unexpectedly positively correlated with SP levels in women. Reduced SP levels were associated with MetS in men but not in women.
Hubungan usia ibu menikah dini dengan status gizi Balita di Kabupaten Temanggung

Latar Belakang : Pernikahan dini (menikah >18 tahun) dapat berpengaruh pada status gizi anak yang dilahirkan. Ibu yang menikah pada usia dini, berisiko memiliki anak berstatus gizi pendek, gizi kurus dan gizi buruk. Tujuan : Penelitian ini bertujuan untuk mengetahui hubungan antara usia ibu menikah dini dengan status gizi batita di Kabupaten Temanggung. Metode : Penelitian ini termasuk penelitian observasi dengan desain cross-sectional pada 72 anak yang berusia 0-2 tahun dari ibu yang menikah dini dan dipilih secara consecutive sampling . Ibu dikatakan menikah dini jika usia ibu saat menikah <18 tahun. Status gizi batita diperoleh dari z-score PB/U dan BB/U menggunakan baku antropometri WHO 2005. Analisis data menggunakan uji Chi-Square. Hasil : Hasil penelitian ini menunjukkan bahwa rerata usia ibu saat menikah dini adalah 15,9±0,98 tahun, sedangkan rerata usia batitanya saat ini 10,4±7,16 bulan. Persentase anak pendek pada kelompok usia ibu yang menikah dini saat berusia 14-15 tahun sebesar 43,5% dan pada kelompok yang menikah saat usia 16-17 tahun sebesar 22,4%. Persentase anak gizi kurang pada kelompok usia ibu yang menikah dini saat berusia 14-15 tahun adalah 17,4%, sedangkan pada kelompok yang menikah saat usia 16-17 tahun sebesar 14,3%. Hal tersebut menunjukkan adanya kecenderungan semakin dini usia nikah ibu, semakin meningkat persentase anak pendek, tetapi secara statistik tidak berhubungan (p=0,067). Begitupula dengan gizi kurang yang juga terdapat kecenderungan semakin dini usia nikah ibu, semakin meningkat persentase gizi kurang, dan secara statistik juga tidak berhubungan (p=0,736). Kesimpulan : Terdapat kecenderungan semakin dini usia ibu menikah, semakin meningkat persentase anak pendek dan gizi kurang, tetapi secara statistik tidak ada hubungan antara usia ibu menikah dini dengan status gizi batita di Kabupaten Temanggung.