Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms.

OBJECTIVE It is generally held that the elderly are more sensitive to motor side effects of antipsychotics, although the mechanisms for such an effect are not fully understood. The objective of this study was to examine whether this sensitivity is due to a central pharmacokinetic (i.e., higher occupancy for a given plasma level) or pharmacodynamic (i.e., greater functional effects for a given occupancy) effect. DESIGN Cross-sectional. SETTING Centre for Addiction and Mental Health, Toronto, Ontario, Canada. PARTICIPANTS Thirteen subjects aged 50 (mean +/- standard deviation age: 62 +/- 9 years) with schizophrenia or schizoaffective disorder who were receiving risperidone. MEASUREMENTS Dopamine D2 binding potential in the striatum, using [C]raclopride positron emission tomography scan. D2 receptor occupancy was calculated, using age-corrected measure from healthy individuals and region of interest analysis. RESULTS The authors observed the expected nonlinear relationship between total risperidone and 9-hydroxyrisperidone plasma level and striatal D2 receptor occupancy. The estimated plasma level of risperidone plus 9-hydroxyrisperidone associated with 50% maximal receptor occupancy was 7.3 ng/mL, which is similar to what has been reported in younger patients. However, extrapyramidal side effects (EPS) were observed in seven subjects at D2 occupancy of 34%-79%, occupancy levels that are lower than previously reported for younger patients in whom EPS are rare at occupancies lower than 80%. CONCLUSION The observation of greater functional effect (EPS in this case) for a given drug occupancy than the younger patients supports a pharmacodynamic mechanism for age-related antipsychotic drug sensitivity. This finding has important implications for dosing of antipsychotics in older patients with schizophrenia.
A termékmegjelenítéssel kapcsolatos attitűdök vizsgálata

Napjainkban egy atlagos fogyaszto a reklamozas uj gyakorlatara lehet figyelmes. A hazai televizios csatornak mű-sorai egyre tobb esetben tartalmaznak a fogyasztok altal is erzekelhető termekmegjelenitesekkel. A termekmegjele-nites lehetősege az eddigi marketingkommunikacios mixbe nehezen illeszthető bele es annak megitelese orszagon-kent elterő lehet. Kutatasunkban felterkepezzuk azokat a hatasokat, amelyek arra batorithatjak a hirdetni szandeko-zokat, hogy eljenek a brand entertainment/product placement – azaz termekmegjelenites lehetősegevel. Celunk, hogy rovid attekintest nyujtsunk arrol, hogy a jelenseg hogyan kepes befolyasolni a fogyasztok vasarlasi szokasait. | Nowadays consumers can experience a new type of advertising. Programs of television channels contain an increasing number of product placements which might be perceived by consumers. Product placement differs from the classical components of the marketing-mix and is evaluated differently in different countries. In our research we explore the effects of product placement in the segment of younger consumers and the reasons for companies to use this special type of advertising. Our goal is to provide a short overview which tries to answer to the question how product placement can influence consumers' buying habits.
Is breath acetone a biomarker of diabetes? A historical review on breath acetone measurements

Since the ancient discovery of the ‘sweet odor’ in human breath gas, pursuits of the breath analysis-based disease diagnostics have never stopped. Actually, the ‘smell’ of the breath, as one of three key disease diagnostic techniques, has been used in Eastern-Medicine for more than three thousand years. With advancement of measuring technologies in sensitivity and selectivity, more specific breath gas species have been identified and established as a biomarker of a particular disease. Acetone is one of the breath gases and its concentration in exhaled breath can now be determined with high accuracy using various techniques and methods. With the worldwide prevalence of diabetes that is typically diagnosed through blood testing, human desire to achieve non-blood based diabetic diagnostics and monitoring has never been quenched. Questions, such as is breath acetone a biomarker of diabetes and how is the breath acetone related to the blood glucose (BG) level (the golden criterion currently used in clinic for diabetes diagnostic, monitoring, and management), remain to be answered. A majority of current research efforts in breath acetone measurements and its technology developments focus on addressing the first question. The effort to tackle the second question has begun recently. The earliest breath acetone measurement in clearly defined diabetic patients was reported more than 60 years ago. For more than a half-century, as reviewed in this paper, there have been more than 41 independent studies of breath acetone using various techniques and methods, and more than 3211 human subjects, including 1581 healthy people, 242 Type 1 diabetic patients, 384 Type 2 diabetic patients, 174 unspecified diabetic patients, and 830 non-diabetic patients or healthy subjects who are under various physiological conditions, have been used in the studies. The results of the breath acetone measurements collected in this review support that many conditions might cause changes to breath acetone concentrations; however, the results from the six independent studies using clearly-defined Type 1 and Type 2 diabetic patients unanimously support that an elevated mean breath acetone concentration exists in Type 1 diabetes. Note that there is some overlap between the ranges of breath acetone concentration in individual T1D patients and healthy subjects; this reminds one to be careful when using an acetone breath test on T1D diagnostics. Comparatively, it is too early to draw a general conclusion on the relationship between a breath acetone level and a BG level from the very limited data in the literature.
Determinants of Capital Structure in Vietnam

This study examines role of various financial variables in determining the capital structure of Vietnamese firms. Although some prior research were conducted within the same context (Nguyen, 2010; Nguyen et al., 2012), they limit testing the contribution of certain firm leverage’s indicators (non-debt tax shields, tax or volatility), which have been found significant at international setting. Besides, the sample period is updated to 2012 in order to capture post-recession effects on capital market if there were any. It is evident from analyses that there are remarkable changes in capital structure’s determinants compared to empirical results. By observing gearing level of 621 non-financial firms listed on either Hanoi Stock Exchange or Ho Chi Minh Stock Exchange, the study suggests that majority of independent variables share effects aligning more closely with patterns found in well-functioning capital markets, such as U.S. or U.K. This contradicts to prior results found in Vietnam, and confirms the belief that recent recovery in the aftermath of financial crisis has been making impact on Vietnamese firms’ financing decisions. It also implies that Vietnamese firms should give more scrutiny and oversight on planning their long-term rather than short-term capital structure.
Extinction and dust/gas ratio in LMC molecular clouds

Aims. The goal of this paper is to measure the dust content and distribution in the Large Magellanic Cloud (LMC) by comparing extinction maps produced in the near-infrared wavelengths and the spatial distribution of the neutral and molecular gas, as traced by Hi and CO observations. Methods. In order to derive an extinction map of the LMC, we have developed a new method to measure the color excess of dark clouds, using the 2MASS all-sky survey. Classical methods to measure the color excess (including the NICE method) tend to underestimate the true color excess if the clouds are significantly contaminated by unreddened foreground stars, as is the case in the LMC. We propose a new method that uses the color of the X percentile reddest stars and which is robust against such contamination. Using this method, it is possible to infer the positions of dark clouds with respect to the star distribution by comparing the observed color excess as a function of the percentile used and that predicted by a model. Results. On the basis of the resulting extinction map, we perform a correlation analysis for a set of dark molecular clouds. Assuming similar infrared absorption properties for the dust in the neutral and molecular phases, we derive the absorption-to-column density ratio AV/NH and the CO-to-H2 conversion factor X_(CO). We show that AV/NH increases from the outskirts of the LMC towards the 30 Dor star-forming region. This can be explained either by a systematic increase of the dust abundance, or by the presence of an additional gas component not traced by Hi or CO, but strongly correlated to the Hi distribution. If dust abundance is allowed to vary, the derived X_(CO) factors for the selected regions are several times lower than those derived from a virial analysis of the CO data. This could indicate that molecular clouds in the LMC are not gravitationally bound, or that they are bounded by substantial external pressure. However, the X_(CO) values derived from absorption can be reconciled with the virial results assuming a constant value for the dust abundance and the existence of an additional, unseen gas component. These results are in agreement with those derived for the LMC from diffuse far-infrared emission.
Is Smoking a Risk Factor for Low Back Pain in Adolescents?: A Prospective Cohort Study

Study Design. A prospective cohort study in adolescents. Objective. To evaluate whether smoking in adolescence is a risk factor of low back pain (LBP) among young adults. Summary of Background Data. Smoking has been found to associate with LBP among adults. Longitudinal studies performed in adolescents are few. Methods. The children belonging to the northern Finland Birth Cohort 1986 were examined at birth and at 16 years of age and followed up by a postal questionnaire at the age of approximately 18 years. The primary outcome was LBP during the past 6-month period. Incident cases reported LBP at 18 but not at 16 years. Persistent cases reported pain at both time points. Logistic regression analysis was used to evaluate the effect of smoking exposure on any LBP in both genders separately and multinomial regression analysis was used to evaluate the effect on the severity of LBP (No LBP, “Reporting LBP,” “Consultation for LBP”) in the total population. Parents’ socioeconomic status, physical activity, body mass index, and depressive mood were used as confounders in the analyses. Results. Regular smoking at 16 years was associated with persistent LBP in girls (OR: 2.52; 95% CI: 1.40–4.53). Daily smoking of over 9 cigarettes at 16 was associated with persistent LBP (2.57; 1.03–6.46) and predicted incident pain in girls (2.80; 1.11–7.09). Pack-years of smoking were associated with incident and persistent LBP in the girls with an exposure-response relationship, whereas these associations were inconsistent in the boys. Pack-years of smoking at 18 years showed an exposure-response relationship with persistent Consultation for LBP, which was strongest in those with over 1.5 pack-years of exposure (5.82; 1.39–24.42). Conclusion. Regular smoking in adolescence was associated with LBP in young adults. Pack-years of smoking showed an exposure-response relationship among girls.
PILOCYTIC ASTROCYTOMA PRESENTING AS BILATERAL OPTIC ATROPHY IN A CHILD: CASE REPORT

Brain tumors are a very common pathology in children today. Optic atrophy is an alerting sign for ophthalmologist that may be associated with serious systemic conditions having a significant bearing on the overall morbidity of the child . We describe here a 14 years old girl who presented with visual loss and features of raised intracranial pressure. On imaging she was diagnosed to have a supratentorial tumor suggestive of central neurocytoma but on histopathology was reported to be pilocytic astrocytoma gradeI. Keywords: Intracranial pressure, Optic atrophy, Pilocytic astrocytoma.
Studies of Children with Learning Disabilities Who Perform Poorly on Memory Span Tasks

This paper describes an extended series of studies focusing on a relatively small subgroup of children with learning disabilities (LD). Children in the subgroup (which constitutes about 15% to 20% of school identified children with LD) have approximately average general intelligence, but perform in the retarded range on tasks that require immediate verbatim recall of sequences of verbal information. Data are provided concerning the severity, stability, and breadth of their memory performance deficits. Experimental analyses of their performance deficits suggest that they result from inefficiency in coding, or representing, the phonological features of language. Further experiments are reported that study the effects of this specific processing difficulty on the performance of complex academic tasks. The primary academic limitation of children in the subgroup appears to involve acquisition of fluent word identification, or word analysis skills. The last section of the paper contains a discussion of remedial implications and future research directions.
Value Creation When Acquiring Public vs Private Firms. Spanish Evidence

We investigate shareholder value creation of Spanish listed firms in response to announcements of acquisitions of unlisted companies and compare this experience to the purchase of listed firms over the period 1991–2011. Similar to foreign markets, acquirers of listed targets earn insignificant average abnormal returns. However, acquirers of listed targets that perform a first bid show significant negative abnormal returns. Acquirers of unlisted targets gain significant positive average abnormal returns. When we relate these results to company and transaction characteristics our evidence suggests that the listing status effect is mainly associated with the fact that unlisted firms tend to be smaller- and lesser-known firms, and thus suffer from a lack of competition in the market for corporate control. Consequently, the payment of lower premiums and the possibility of diversifying shareholders’ portfolios lead to unlisted firm acquisitions being viewed as value-orientated transactions.
Loss Firms and Analysts' Earnings Forecast Errors

An examination of analysts' accuracy in predicting annual earnings for firms reporting losses and firms reporting profits finds that analysts are ten times more accurate in predicting the earnings of profit firms. They have also improved their predictive ability for profit firms since the mid-1980s. The sample includes eighteen years of coverage by IBES and Compustat analysts.
ON THE DETECTABILITY OF DUAL JETS FROM BINARY BLACK HOLES

We revisit the suggestion that dual jets can be produced during the inspiral and merger of supermassive black holes when these are immersed in a force-free plasma threaded by a uniform magnetic field. By performing independent calculations of the late inspiral and merger, and by computing the electromagnetic (EM) emission in a way which is consistent with estimates using the Poynting flux, we show that a dual-jet structure is present but energetically subdominant with respect to a non-collimated and predominantly quadrupolar emission, which is similar to the one computed when the binary is in electrovacuum. While our findings set serious restrictions on the detectability of dual jets from coalescing binaries, they also increase the chances of detecting an EM counterpart from these systems.
Prevalence of Recurrent Aphthous Ulceration in the Diyala Population

Background: Recurrent aphthous stomatitis (RAS) are an inflammatory condition and most the common ulceration of the oral cavity of the patients that make them to ask dental practitioner consultation. most ulcers are associated with pain and heals spontaneously for some days. Objective: To calculate the prevalence of this type of ulcers in diyala governorate among males and females and its association with stress and evaluate the independent issues correlated to this oral mucosal state. Patients and Methods: A total of 80 patients who attended to the Baquba teaching hospital from April 2016 April 2017 and fill the required questioner of this study which including age, gender, site, size of ulcer, stressed condition and smoking status in addition to other questions. Results: The prevalence of RAS was 17.4%, the third decade of life were the most affected age. Males were affected more than females and the tongue were the most affected sites represents (25 %)of the cases. stress was the most causative factors of this lesions. Conclusion: In diyala governorate, the Aphthus lesion is the main features of stress among males.
Naturally occurring and added sugar in relation to macronutrient intake and food consumption: results from a population-based study in adults

Abstract Associations between sugar intake and the remaining diet are poorly described in modern food environments. We aimed at exploring associations of high naturally occurring and added sugar intakes with sociodemographic characteristics, intake of macronutrients, fibre and selected food groups. Our data comprised 4842 Finnish adults aged 25–74 years, who participated in the population-based DIetary, Lifestyle and Genetic determinants of Obesity and Metabolic syndrome (DILGOM) study. Diet was assessed by a validated 131-item FFQ. The food item disaggregation approach was used to estimate sucrose and fructose intakes from natural sources (naturally occurring sugar) and all other sources (added sugar). Sex-specific trends in macronutrient, fibre and food group intakes across sugar type quartiles were determined with general linear modelling adjusting for age, energy intake, leisure-time physical activity, smoking, education and BMI. Overall, results were similar across sexes. Young age was found to be a determinant of higher added sugar and lower naturally occurring sugar intakes (P < 0·0001). High added sugar intake was associated with low fibre intake (P < 0·0001) accompanied with lower fruit (P < 0·0001 women; P = 0·022 men) and vegetable consumption (P < 0·0001) and higher wheat consumption (P = 0·0003 women; P < 0·0001 men). Opposite results were found for naturally occurring sugar. Butter consumption increased by 28–32 % (P < 0·0001) when shifting from the lowest to the highest added sugar intake quartile, while a decrease of 26–38 % (P < 0·0001) was found for naturally occurring sugar. Therefore, the associations of sugar types with dietary carbohydrate and fat quality seem opposing. Proper adjustments with dietary variables are needed when studying independent relationships between sugar and health.
Topical Alprostadil in the Treatment of Female Sexual Arousal Disorder: A Pilot Study

This study evaluated the efficacy and safety of three doses of topical alprostadil* USP (prostaglandin E 1 ) cream in 8 patients with Female Sexual Arousal Disorder (FSAD). Each patient was administered a single intravaginal dose of placebo followed by escalating intravaginal doses of the active drug at 2-week intervals. Alprostadil's effectiveness in enhancing subjective and physiological arousal during visual sexual stimulation was supported by patient ratings and physician assessments of vaginal erythema and transudate volume. Photoplethysmography measurement of vaginal pulse amplitude was not able to demonstrate treatment sensitivity in the present study. Adverse events included mild cases of vaginal itching and burning. The data support further investigation of the use of alprostadil for FSAD.
ANALISIS SALURAN PEMASARAN DAN MARJIN PEMASARAN KELAPA DALAM DI DAERAH PERBATASAN KALIMANTAN TIMUR

This study aims to analyze the efficiency of marketing channels and marketing margins in the coconut. The method used is descriptive and analytical methods margin, distribution margins and share price received by farmers as well as the ratio of benefits and costs in the oil marketing. The results indicated that there were two oil marketing channels in the research sites, namely the channel I: farmer traders village/district – middlemen between districts/cities – consumer: and marketing channels II: farmer – traders village/district – traders collector between districts/cities – retailer – consumer where botk inefficient marketing channels and marketing of coconut in view of the value of margin, distribution margins and share price received by farmers, as well as the ratio of benefits and costs is also inefficient.
A Task Scheduling Based on Simulated Annealing Algorithm in Cloud Computing

Because the task scheduling problem is np-complete problem, it is hard to find a deterministic algorithm to solve the problem of task scheduling in the cloud computing platform. Therefore this paper presents a task scheduling mechanism based on simulated annealing algorithm. The algorithm is a modern heuristic algorithm and overcome the shortcoming of the local optimum search method. The algorithm uses a greedy algorithm to generate the initial value, and heat to a sufficiently high temperature and according to certain rules to generate a new value. If the new value is better than the original value or at a certain probability can be accepted, then replace the original value with the new value until cool. Experiments proved the feasibility and effectiveness of the algorithm. Compared with traditional algorithms, this task scheduling mechanism not only meets the needs of users and improves the performance of the system.
Evaluation and comparison of coagulation factor activity in fresh‐frozen plasma and 24‐hour plasma at thaw and after 120 hours of 1 to 6°C storage

BACKGROUND: Current transfusion‐related acute lung injury reduction strategies include avoiding transfusion of plasma products collected from female donors or female donors that have been pregnant to reduce transfusion of plasma‐containing HLA antibodies. Such a policy considerably decreases the number of donors available for generation of fresh‐frozen plasma (FFP). To increase the supply of FFP, substitution of 24‐hour plasma (FP24) and thawed plasma (TP) derived from either FFP or FP24 may be viable substitutes. To justify such a policy the coagulation factor content of FFP, FP24, and TP derived from both product types was assessed.
The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae

Normal cell growth in the yeast Saccharomyces cerevisiae involves the selection of genetically determined bud sites where most growth is localized. Previous studies have shown that BEM2, which encodes a GTPase-activating protein (GAP) that is specific for the Rho-type GTPase Rho1p in vitro, is required for proper bud site selection and bud emergence. We show here that DBM1, which encodes another putative Rho-type GAP with two tandemly arranged cysteine-rich LIM domains, also is needed for proper bud site selection, as haploid cells lacking Dbm1p bud predominantly in a bipolar, rather than the normal axial, manner. Furthermore, yeast cells lacking both Bem2p and Dbm1p are inviable. The nonaxial budding defect of dbm1 mutants can be rescued partially by overproduction of Bem3p and is exacerbated by its absence. Since Bem3p has previously been shown to function as a GAP for Cdc42p, and also less efficiently for Rho1p, our results suggest that Dbm1p, like Bem2p and Bem3p, may function in vivo as a GAP for Cdc42p and/or Rho1p. Both LIM domains of Dbm1p are essential for its normal function. Point mutations that alter single conserved cysteine residues within either LIM domain result in mutant forms of Dbm1p that can no longer function in bud site selection but instead are capable of rescuing the inviability of bem2 mutants at 35 degrees C.