Miracle-dz/UniFAR-FTUs huggingface dataset:
Corporate governance and firm value: a comparative analysis of state and non-state owned companies in the context of Pakistan

Purpose The purpose of this paper is to examine how corporate governance instruments impact firm value in the context of Pakistan. This paper considers state- and non-state-owned enterprises and examines whether the influence of corporate governance on firm value varies across firms having different nature of ownership. Design/methodology/approach This study opts for an unbalanced sample of state- and non-state-owned enterprises for the period 2010-2014. Panel data regression is adopted for estimation of main results. The suitable model, i.e. fixed and random effect model, is selected using Hausman specification test. Findings The notable findings show that board independence has a significant and positive relationship with firm value only for state-owned companies. Furthermore, the results show that market capitalization and return on assets have a significant and positive association with firm value for both state- and non-state-owned enterprises. All other variables are found insignificant for both state- and non-state-owned companies, but the results are consistent with those reported in previous studies. Practical implication The findings of the study suggest that fair induction of independent directors, appropriate board size and cost-benefit analysis to conduct frequent meetings can help corporations to improve their performance. Originality/value This study is adding to the current literature by providing new insights and shows that the impact of corporate governance on firm value varies across firms of different types of ownership, i.e. state- and non-state-owned enterprises.
Cognitive Abilities, Analytic Cognitive Style and Overconfidence: A Commentary on Duttle (2016)

In his recent paper, Duttle (2016) showed that individuals with higher cognitive abilities show less overconfidence. In these findings, cognitive abilities were equated with an analytic cognitive style (as measured by a cognitive reflection test, or CRT), although recent works in the field of cognitive psychology suggest separating these two constructs. In particular, it is argued that the analytic cognitive style, but not cognitive abilities, decreases susceptibility to cognitive biases. Analyses of data from Duttle's study support this assertion. Implications for cognitive psychology and behavioural economics are discussed.
Mechanisms compensating for dopamine loss in early Parkinson disease

Parkinson disease (PD) is a disorder with a substantive period before the emergence of motor symptoms, during which significant dopaminergic neuronal loss is counterbalanced by endogenous compensatory mechanisms. Many potential compensatory mechanisms have now been proposed; these are both dopaminergic, focused on enhancing effects or exposure to existing dopamine, and nondopaminergic, being focused on reducing activity of the indirect striatal output pathway. Compensatory mechanisms can potentially postpone and reduce the severity of parkinsonian symptoms, and contribute to the benefit provided by a symptomatic therapy, thus offering targets for novel therapeutics. However, enhancement of certain compensatory mechanisms may produce problems when subsequent therapies are initiated, e.g., the development of motor complications with levodopa. Supporting endogenous compensatory mechanisms, to delay or reverse apparent disease progression, is a novel and attractive “disease-modifying” approach to PD. Such actions may contribute to the apparent disease-modifying benefit of initiating early treatment with levodopa or rasagiline, as suggested by the ELLDOPA and TEMPO studies.
The 9-11 Commission’s invitation to imagine: A pathophysiology-based approach to critical care of nuclear explosion victims*

Objective:The successful management of mass casualties arising from detonation of a nuclear device (NDD) would require significant preparation at all levels of the healthcare system. This article briefly outlines previously published models of destruction and casualties, details approaches to on-site triage and medical evacuation, and offers pathophysiology-based suggestions for treatment of the critically injured. Documentation from previous bomb blasts and nuclear accidents is reviewed to assist in forecasting needs of both systems and patients in the event of an NDD in a major metropolitan area. Data Sources/Study Selection:This review extracts data from previously published models of destruction and casualties projected from an NDD, the primary literature detailing observations of patients’ pathophysiology following NDDs in Japan and relevant nuclear accidents, and available contemporary resources for first responders and healthcare providers. Data Extraction/Synthesis:The blast and radiation exposures that accompany an NDD will significantly affect local and regional public resources. Morbidity and mortality likely to arise in the setting of dose-dependent organ dysfunction may be minimized by rigorous a priori planning/training for field triage decisions, coordination of medical and civil responses to effect rapid responses and medical evacuation routes, radiation-specific interventions, and modern intensive care. Conclusions:Although the responses of emergency and healthcare systems following NDD will vary depending on the exact mechanism, magnitude, and location of the event, dose exposures and individual pathophysiology evolution are reasonably predictable. Triage decisions, resource requirements, and bedside therapeutic plans can be evidence-based and can be developed rapidly with appropriate preparation and planning.
How Geotagged Social Media Can Inform Modern Travelers

Modern tourists travel in new ways. The rising class of so-called “Creative tourists” prefer to explore everyday life instead of simply ticking off a list of sights to see. However, travel guides all currently represent places as simply a collection of sights. At the same time, public geotagged social media data is opening a new world of ways to investigate another place. In this thesis, I describe efforts to bring these trends together, by developing neighborhood guides for travelers, based on social media. I first investigate why people geotag and where this public geotagged data comes from. Then, after developing a model of what tourists want through a series of interviews and surveys, I develop a prototype social-media-based neighborhood guide for travelers. By an iterative user study and quantitative investigation into photo sources, I find that this data can give users an ideal glimpse into a new city. Implications are widespread: I show not only how social media can be used to help people travel, but also develop a perspective on what social media tells, and does not tell, about cities and neighborhoods. I show that social media provides an idealized qualitative image into a city, while perhaps not reflecting the objective, quantitative reality. This matches tourists’ needs ideally, providing an exciting new opportunity for a new generation of tourism tools. ACKNOWLEDGEMENTS 0.
Travel risk dimensions, personal-related factors, and intention to visit a destination: a study of young educated German adults

ABSTRACT The study examines travel risk dimensions and their relationships with tourist role, past visit experience, gender and intention to visit Thailand among young educated German adults. Using an online survey of 323 German university students, six dimensions of travel risk perception and their relationships with tourist role and past travel experience were revealed. Over-commercialisation risk was found to be the most concerned risk and produce different relationships with tourist role and travel experience from other types of risks. Although political risk was of least concern, it was confirmed as the only risk having a negative influence on travel intention.
The intercultural ethics agenda from the point of view of a moral objectivist

Purpose – The purpose of this paper is to attempt to resolve some unclarity about the nature and character of intercultural information ethics (IIE). Design/methodology/approach – By survey of some of the relevant literature, the paper identifies and explains the distinctive projects of IIE. In addition, to facilitate the achievement of these projects, the paper attempts to identify the most fruitful metaphysical and meta‐ethical assumptions about truth and moral truth. In particular, to identify and determine which of objectivist theories of truth and morality or intersubjectivist theories of truth and morality provides a better theoretical foundation for IIE.Findings – Two projects are identified: a descriptive project and a normative project. It is argued that moral objectivism provides a better foundation for the normative (project than moral intersubjectivism (or, as it is sometimes called, normative cultural relativism) in the sense that objectivism provides a more solid ground for the principle grou.
Head-to-Head Comparison of 11C-PBR28 and 18F-GE180 for Quantification of the Translocator Protein in the Human Brain

18F-GE180 is a third-generation PET tracer for quantifying the translocator protein (TSPO), a biomarker for inflammation. The aim of this study was to perform a head-to-head comparison of 18F-GE180 and the well-established TSPO tracer 11C-PBR28 by scanning with both tracers during the same day in the same subjects. Methods: Five subjects underwent a 90-min PET scan with 11C-PBR28 in the morning and 18F-GE180 in the afternoon. A metabolite-corrected arterial input function was obtained in each subject for both tracers, and the brain uptake was quantified with a 2-tissue-compartment model. Results: The rate of metabolism of 18F-GE180 in arterial blood was slower than that of 11C-PBR28 (the percentages of nonmetabolized parent in plasma at 90 min were 74.9% ± 4.15% [mean ± SD] and 11.2% ± 1.90%, respectively). The plasma free fractions were similar for both tracers: 3.5% ± 1.1% for 18F-GE180 and 4.1% ± 1.1% for 11C-PBR28. The average total volume of distribution (VT) of 18F-GE180 was about 20 times smaller than that of 11C-PBR28 (0.15 ± 0.03 mL/cm3 for 18F-GE180 and 3.27 ± 0.66 mL/cm3 for 11C-PBR28). 18F-GE180 was characterized by poor transfer from the vascular compartment to the brain (its plasma-to-tissue rate constant [K1] was about 10 times smaller than that of 11C-PBR28). Moreover, kinetic modeling was more difficult with 18F-GE180, as its VT values were identified with a lower precision than those of 11C-PBR28 and outlying values were more frequent. Conclusion: The VT of 18F-GE180 was about 20 times smaller than that of 11C-PBR28 because of low penetration into the brain from the vascular compartment. In addition, kinetic modeling of 18F-GE180 was more challenging than that of 11C-PBR28. Therefore, compared with 11C-PBR28, 18F-GE180 had unfavorable characteristics for TSPO imaging of the brain.
Epigenetic markers for newborn congenital heart defect (CHD)

Abstract Objective: Our objective was to determine whether there were significant differences in genome-wide DNA methylation in newborns with major congenital heart defect (CHD) compared to controls. We also evaluated methylation of cytosines in CpG motifs for the detection of these CHDs. Methods: Genome-wide DNA methylation analysis was performed on DNA from 60 newborns with various CHDs, including hypoplastic left heart syndrome, ventricular septal deficit, atrial septal defect, pulmonary stenosis, coarctation of the aorta and Tetralogy of Fallot, and 32 controls. Results: Highly significant differences in cytosine methylation were seen in a large number of genes throughout the genome for all CHD categories. Gene ontology analysis of CHD overall indicated over-represented biological processes involving cell development and differentiation, and anatomical structure morphogenesis. Methylation of individual cytosines in CpG motifs had high diagnostic accuracy for the detection of CHD. For example, for coarctation one predictive model based on levels of particular cytosine nucleotides achieved a sensitivity of 100% and specificity of 93.8% (AUC = 0.974, p < 0.00001). Conclusion: Profound differences in cytosine methylation were observed in hundreds of genes in newborns with different types of CHD. There appears to be the potential for development of accurate genetic biomarkers for CHD detection in newborns.
How to measure disease activity in axial spondyloarthritis?

Purpose of reviewThe evaluation of disease activity in axial spondyloarthritis (SpA) is complex and multifactorial. Moreover, patients and physicians have different perspectives of the disease and none of the current single-item or combined indexes adequately unifies both perspectives. Recent efforts have been made to improve disease activity measurement in axial SpA. Recent findingsThe Assessment of Spondyloarthritis international Society (ASAS) embraced the project of developing a new index for disease activity measurement in axial SpA: the Ankylosing Spondylitis Disease Activity Score (ASDAS). The process closely mimicked the development of the Disease Activity Score in rheumatoid arthritis. Cut-offs for disease activity states and response levels have also been developed. Good performance of ASDAS has been shown in several international datasets, including randomized controlled trials and observational cohorts. SummaryThe ASDAS is a well balanced index covering the underlying construct of disease activity and designed to avoid redundancy. It is a feasible and valid measurement instrument with a very good performance compared to existing tools. The ASDAS and its cut-off values may help clinicians and researchers to better assess patients with axial SpA, more reliably determine their disease activity status, the effectiveness of treatments and whether they are providing clinically meaningful improvement.
[Effect of intensive insulin therapy on apoptosis-related ligands in serum in rats with severe scald].

OBJECTIVE To investigate changes in apoptosis-related ligands in serum in rats with severe scald and the effect of intensive insulin therapy on the changes. METHODS One hundred and fifty Wistar rats were randomly divided into 3 groups: sham burn (SB), scald (S) and treatment (T) groups. Rats in S and T groups were inflicted with 40% TBSA full-thickness burn, followed by intraperitoneal injection with 40 mL/kg of isotonic saline for resuscitation. Rats in T group were subcutaneously injected insulin in a dose of 0.25 U/100 g 24 hours after burn injury, and every 12 hours for 5 days (0.25, 0.50, 0.75, 1.00, 1.25 U/100 g each day, respectively) to control the level of blood glucose between 3 and 6 mmol/L. Rats in SB group were sham scalded at 37 degrees C without resuscitation. Blood was drawn from abdominal aorta on 1, 4, 7, 10, 14 post burn day (PBD) for determination of serum levels of TNF-alpha, soluble Fas ligand (sFasL) and soluble Fas receptor (sFas) by enzyme-linked immunosorbent assay (ELISA), and insulin by radioimmunity assay (RIA). RESULTS The serum level of TNF-alpha in S group peaked on 1 PBD (30.9 +/- 8.7) ng/L, which showed statistically significant difference when compared with that of SB and T groups (12.7 +/- 2.8) ng/L, (16.8 +/- 4.7) ng/L, respectively, P < 0.01), then lowered gradually to become similar to that of SB group on 7 PBD. The level of TNF-alpha in T group increased gradually, but was obviously lower than that of S group on 1, 4, 7 PBD (P < 0.01). The level of sFasL in S (on 7-14 PBD) and T (4-10 PBD) groups was significantly higher than that in SB group (P < 0.05), then lowered to normal level. The levels of sFas on 4-10 PBD in T group were obviously higher than that in S and SB group (P < 0.05). Ratio of sFasL to sFas in serum of S group was higher than that in SB group on 7, 10 PBD, which was higher than that in T group on 7 PBD (P < 0.05). There was significant decrease in serum level of insulin in S group compared with that of SB group on 4-10 PBD (P < 0.05). The level of insulin in T group increased on 1 PBD, peaked on 4 PBD (327 +/- 15 microU/mL), which was significantly higher than that in SB and S groups (42 +/- 15, 28 +/- 10 microU/mL, respectively, P < 0.01), then decreased gradually to normal level. CONCLUSIONS Insulin may inhibit apoptosis after burn by down-regulating secretion of apoptotic ligands.
Hepatoprotective effect of germanium-containing Spirulina in rats with d-galactosamine- and lipopolysaccharide-induced hepatitis

In the present study, the protective effects of dietary Spirulina (SP) and germanium-containing Spirulina (GeSP) were compared in rats with liver injury induced by an intraperitoneal injection of d-galactosamine and lipopolysaccharide (GalN/LPS). Wistar rats were fed one of the following diets: the basal diet (GalN/LPS-CON group; n 6), the basal diet supplemented with 5 % SP or GeSP (GalN/LPS-SP and GalN/LPS-GeSP group, respectively; n 7 each). After administering these diets for 7 d, each rat was intraperitoneally injected with GalN/LPS. Increases in plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were suppressed in the GalN/LPS-GeSP group (GalN/LPS-CON v. GalN/LPS-GeSP: ALT 1052 (sem 187) v. 509 (sem 88) IU/l and AST 2183 (sem 368) v. 1170 (sem 196) IU/l) following the injection of GalN/LPS. Plasma levels of interferon-γ (IFN-γ) and TNF-α in GeSP-fed rats were significantly lower when compared with those in the GalN/LPS-CON group (GalN/LPS-CON v. GalN/LPS-GeSP: IFN-γ 142·8 (sem 17·5) v. 66·8 (sem 9·7) pg/ml and TNF-α 72·3 (sem 15·4) v. 31·2 (sem 6·8) pg/ml). However, the decrease in these levels observed in the GalN/LPS-SP group was not as prominent as those observed in the GalN/LPS-GeSP group. Furthermore, the increase in liver catalase (CAT) and glutathione peroxidase (GPx) activities, as well as the level of oxidised glutathione (GSSG), was more suppressed in GeSP-fed rats (GalN/LPS-CON v. GalN/LPS-GeSP: CAT 457 (sem 47) v. 262 (sem 54) U/mg liver protein; GPx 1·30 (sem 0·11) v. 0·53 (sem 0·09) U/mg liver protein; GSSG 2·18 (sem 0·33) v. 1·31 (sem 0·24) mmol/kg liver) after the injection of GalN/LPS. These changes were more pronounced in the GalN/LPS-GeSP group than in the GalN/LPS-SP group. These results suggest that GeSP could afford a significant protective effect in the alleviation of GalN/LPS-induced hepatic damage. In addition, the results indicate that GeSP is more effective than SP.
Effect of Within-and Between-Speaker Variability in Voice Quality on Speaker Recognition

The variability in voice quality is a critical factor in most of speech-related applications, but studies regarding this variability are scarce due to the absence of an adequate database. Based on the newly developing database, this study examines the effect of withinand between-speaker variability on speaker recognition systems. The preliminary results with a subset of the database show that voice quality variability can cause a significant degradation in speaker identification performance. It is also found that widely-used features, such as cepstral coefficients, are not robust in the presence of the voice quality change, but that the robustness can be improved by fusing with perceptually important voice quality features. Further studies will include analyzing the whole database, improving voice quality measurement, and developing a model to represent an individual’s vocal identity.
Efficacy of cancellous block allograft augmentation prior to implant placement in the posterior atrophic mandible.

BACKGROUND The present study evaluated the outcome of ridge augmentation with cancellous freeze-dried block bone allografts in the posterior atrophic mandible followed by placement of dental implants. MATERIALS AND METHODS A bony deficiency of at least 3 mm, horizontally, vertically, or both, according to computerized tomography (CT) para-axial reconstruction served as inclusion criteria. Implants were inserted after a healing period of 6 months. Bone measurements were taken prior to bone augmentation, during implant placement, and at second-stage surgery. Marginal bone loss and crown-to-implant ratio were also measured. RESULTS Twenty-nine cancellous allogeneic bone blocks were placed in 21 patients. The mean follow-up was 37 months. Bone block survival rate was 79.3%. Mean horizontal and vertical bone gains were 5.6 and 4.3 mm, respectively. Mean buccal bone resorption was 0.5 mm at implant placement and 0.2 mm at second-stage surgery. A total of 85 implants were placed. Mean bone thickness buccal to the implant neck was 2.5 mm at implant placement and 2.3 mm at second-stage surgery. There was no evidence of vertical bone loss between implant placement and second-stage surgery. Implant survival rate was 95.3%. All patients received a fixed implant-supported prosthesis. At the last follow-up, the mean marginal bone loss was 0.5 mm. The mean crown-to-implant ratio was 0.96. CONCLUSION Implant placement in the posterior atrophic mandible following augmentation with cancellous freeze-dried bone block allografts may be regarded as a viable treatment alternative.
The Effects of Rooming-in on the Success of Breastfeeding and the Decline in Abandonment of Children

This study analyzed the effect of management of rooming-in, conducted in one of the regional hospitals in Thailand, on the success of breastfeeding. Data based on 2, 000 infants born in 1987 and 1990 showed a significant improvement on separation time of infant and mother after delivery and predominant breastfeeding, where the infant's predominant source of nourishment has been breastmilk. Separation time was reduced from 6.3 ± 3.2 to 1.62 ± 0.42 hours and predominant breastfeeding was significantly increased from 85 to 99 percent. Data obtained from the community related to the initiation and predominant breastfeedings showed a significant increase (p<0.05). No significant difference was demonstrated, however, on current breastfeeding among infants who were delivery before and after initiation of the rooming-in system. Also analyzed were data on prevalence of deserted children. The findings showed a progressive reduction of deserted children after management of rooming-in. The study concludes that the practices of obstetricians were a key to successful breastfeeding. Promotion and management of rooming-in significantly improves the success of breastfeeding and reduction of deserted children in the hospital.
Level and Determinants of Food Security in North Wollo Zone (Amhara Region – Ethiopia)

This paper examines the Determinants of food security in North Wollo Zone. Primary data from 335 households were collected from 16 kebeles of the zone. We used multistage sampling technique, and questionnaire and FGD were used to collect primary data. Both descriptive and econometric method of analysis were used. For econometric analysis, a logistic regression procedure was employed on household socio-economic cross-sectional data collected in 2016 (April and May). Of the fifteen variables fitted in the model; the age of household head, dependency ratio, average monthly expenditure, non-farm income, family size, distance from input market, farmland size, the number of oxen and livestock ownership were found to be significant. About 42 percent of the sample households were measured to be food insecure. Also, the incidence of food insecurity, food insecurity gap, and severity of food insecurity was 42, 14 and 7 percent respectively. These results have important policy implications for the expansion of non-farm activities and the introduction of livestock stocking programs at the household level to improve the food security status of households.