Miracle-dz/UniFAR-FTUs huggingface dataset:
PROTOCOLO DE ENFERMAGEM EM ATENDIMENTO EMERGENCIAL: SUBSÍDIOS PARA O ACOLHIMENTO ÀS VÍTIMAS

Este estudio es de naturaleza descriptiva exploratoria y tuvo el objetivo de proponer protocolos de atendimiento de enfermeria a partir de la identificacion de los motivos de demanda y de la caracterizacion del perfil de las victimas acogidas en el sector triage de un Pronto Socorro. La muestra se constituyo de 203 fichas de atendimiento del mes de marzo de 2008 que, analizadas descriptivamente, sirvieron de base para el establecimiento de protocolos. El resultado demuestra media de edad de 39 anos, y los mecanismos de trauma fueron caidas y accidentes de transito. Los atendimientos triados fueron evaluacion del dolor y retorno, primer atendimiento, yeso e infeccion. La distribucion de las victimas y clasificacion de riesgo permanecio en el color verde, o sea, paciente critico, en observacion o aguardando vaga, concluyendo 65% de la atencion al trauma. Se sugiere la realizacion de otros estudios basados en la actual politica institucional, en proceso de adecuacion a la propuesta ministerial.
Application of AHP and ELECTRE models for assessment of dedesertification alternatives

The assessment of de-desertification alternatives can be effective in controlling the reclamation of disturbed landand avoiding destruction of areas at risk. Until now, there has been no method to consider different criteria andalternatives, or to present the optimum alternatives based on systematic structures and experts’ perspectives.Desertification is a complex process resulting from various factors, including anthropogenic activities; the selectionof optimum alternatives is a very difficult task. This paper attempts to represent the optimum alternatives based onthe Multiple Attribute Decision-Making Model (MADM). For this purpose, the initial priorities for alternatives weredetermined by Expert Choice (EC) software via Elimination and Choice Translating Reality (known as ELECTRE). Then, the final priorities for alternatives were assessed using the Analytical Hierarchy Process (AHP). This modelwas tested in the Khezr Abad region, Yazd Province, to evaluate the determination of optimum alternatives. Theresults indicated that prevention of unsuitable land use changes, vegetation cover development and reclamation, andchanges in groundwater harvesting, with weight averages of 22.9, 21.8 and 19.1 %, respectively, are the mostimportant desertification alternatives in the study area.
Deadbeat Predictive Current Control of Permanent-Magnet Synchronous Motors with Stator Current and Disturbance Observer

In order to optimize the current-control performance of the permanent-magnet synchronous motor (PMSM) system with model parameter mismatch and one-step control delay, an improved deadbeat predictive current control (DPCC) algorithm for the PMSM drive systems is proposed in this paper. First, the performance of the conventional predictive current control, when parameter mismatch exist, is analyzed, and then a stator current and disturbance observer (SCDO) based on sliding-mode exponential reaching law, which is able to simultaneously predict future value of stator current and track system disturbance caused by parameter mismatch in real time, is proposed. Based on this SCDO, prediction currents are used for replacing the sampled current in DPCC to compensate one-step delay, and estimated parameter disturbances are considered as the feedforward value to compensate the voltage reference calculated by deadbeat predictive current controller. Thus, a composite control method combining the DPCC part and current prediction and feedforward compensation part based on SCDO, called DPCC + SCDO method, is developed. Moreover, based on conventional exponential reaching law, a novel sliding-mode exponential reaching law is proposed to further improve the performance of the DPCC + SCDO method. Simulation and experimental results both show the validity of the proposed current control approach.
Weird past tense forms

ABSTRACT It is often assumed that children go through a stage in which they systematically overapply irregular past tense patterns to inappropriate verbs, as in wipe-wope, bring-brang, trick-truck, walk-has walken. Such errors have been interpreted both as reflecting over-use of minor grammatical rules (e.g. ‘change i to a’), and as reflecting the operation of a connectionist pattern associator network that superimposes and blends patterns of various degrees of generality. But the actual rate, time course, and nature of these errors have never been documented. We analysed 20,000 past tense and participle usages from nine children in the CHILDES database, looking for overapplications of irregular vowel-change patterns, as in brang, blends, as in branged, productive suffixations of -en, as in walken, gross distortions, as in mail-membled, and double-suffixation, as in walkeded. These errors were collectively quite rare; children made them in about two tenths of one per cent of the opportunities, and with few stable patterns: the errors were not predominantly word-substitutions, did not occur predominantly with irregular stems, showed no consistency across verbs or ages, and showed no clear age trend. Most (though not all) of the errors were based closely on existing irregular verbs; gross distortions never occurred. We suggest that both rule-theories and connectionist theories have tended to overestimate the predominance of such errors. Children master irregular forms quite accurately, presumably because irregular forms are just a special case of the arbitrary sound-meaning pairings that define words, and because children are good at learning words.
Childhood Sexual Abuse and Psychosomatic Symptoms in Irritable Bowel Syndrome

ABSTRACT Irritable bowel syndrome is characterized by chronic gastrointestinal symptoms without a demonstrable physical cause. In a subgroup of patients, irritable bowel syndrome may be part of a cluster of psychosomatic symptoms related to childhood sexual abuse. To investigate this possibility, the Dissociative Disorders Interview Schedule (DDIS), the Dissociative Experiences Scale (DES) and the Symptom Checklist-90 (SCL-90) were administered to 105 subjects with either irritable bowel syndrome, inflammatory bowel disease (Crohn's disease or ulcerative colitis), or other gastrointestinal disorders. The subjects in the three groups did not differ on the DES, the SCL-90 or most sections of the DDIS. However, subjects with irritable bowel syndrome reported much higher rates of childhood sexual abuse and psychosomatic symptoms.
Poor long-term prognosis in mixed bipolar patients: 10-year outcomes in the Vitoria prospective naturalistic study in Spain.

OBJECTIVE There have been few prospective long-term naturalistic studies of patients with mixed episodes of bipolar disorder. The aim of this study was to examine 10-year outcomes in patients with at least 1 mixed episode. METHOD A naturalistic sample of bipolar I disorder patients (n = 120), representative of bipolar patients treated in a catchment area of Spain, was followed prospectively for up to 10 years. Outcomes including number (primary study outcome) and severity of episodes, hospitalizations, and suicide attempts were recorded at bimonthly visits. Bivariate and logistic regression models identified factors significantly associated with mixed episodes. The study was conducted from 1994 through 2004. RESULTS 37% of patients had mixed episodes. Mixed-episode patients had younger mean age at onset compared with the nonmixed group (25.3 vs 30.8 years; P = .025). After adjusting for age at onset, mixed-episode patients had an increased risk of hospitalization compared with the nonmixed group (OR = 2.86; 95% CI, 1.09-7.52; P = .033) and more episodes (OR = 1.21; 95% CI, 1.10-1.31; P < .001). Other differences between mixed and nonmixed patients, such as alcohol abuse, psychotic symptoms, and suicidality, were partially mediated by age at onset and were not significantly different after controlling for this variable. Mixed-episode patients with previous suicide attempts had a significantly shorter time to first suicide attempt during follow-up than those without history of suicide attempts (P = .014). CONCLUSIONS Although some factors associated with mixed episodes are mediated by a younger age at onset, the long-term prognosis of mixed-episode patients is worse than patients with nonmixed episodes.
Eight philosophers of the Italian renaissance

Italian Renaissance thought has been gaining ever-increasing recognition as seminal to the thought of the whole Renaissance period, affecting in many subtle ways the development and understanding of artistic, literary, scientific, and religious movements. The importance, then, of this detailed and careful survey of Italy's leading Renaissance philosophers and the intricate philosophical problems of the time can scarcely be exaggerated. Based upon the 1961 Arensberg Lectures, given at Stanford University, this collection of essays offers a genuinely unified interpretation of Italian Renaissance thought by describing and evaluating the philosophies of eight pivotal figures: Petrarch, Valla, Ficino, Pico, Pomponazzi, Telesio, Patrizi, and Bruno. The essays not only discuss the life, writings, and main ideas of these eight thinkers, but also establish through a connective text, the place each of them occupies in the general intellectual development of the Italian Renaissance.
American Sign Language Translation through Sensory Glove; SignSpeak

To make a communication bridge, a highly accurate, cost effective and an independent glove was designed for deaf/mute people to enable them to communicate. The glove translates the sign language gestures into speech according to the American Sign Language Standard. The glove contained flex and contact sensors to detect the movements of the fingers and bending of the palm. In addition an accelerometer was built in the glove to measure the acceleration produced by the changing positions of the hand. Principal Component Analysis (PCA) was used to train the glove into recognizing various gestures, and later classify the gestures into alphabets in real time. The glove then established a Bluetooth link with an Android phone, which was used to display the received letters and words and convert the text into speech. The glove was found to have an accuracy of 92%.
Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue

Gravholt, Claus Højbjerg, Ole Schmitz, Lene Simonsen, Jens Bülow, Jens Sandahl Christiansen, and Niels Møller. Effects of a physiological GH pulse on interstitial glycerol in abdominal and femoral adipose tissue. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E848–E854, 1999. — Physiologically, growth hormone (GH) is secreted in pulses with episodic bursts shortly after the onset of sleep and postprandially. Such pulses increase circulating levels of free fatty acid and glycerol. We tested whether small GH pulses have detectable effects on intercellular glycerol concentrations in adipose tissue, and whether there would be regional differences between femoral and abdominal subcutaneous fat, by employing microdialysis for 6 h after administration of GH (200 μg) or saline intravenously. Subcutaneous adipose tissue blood flow (ATBF) was measured by the local Xenon washout method. Baseline of interstitial glycerol was higher in adipose tissue than in blood [220 6 12 (abdominal) vs. 38 6 2 (blood) μmol/l, P , 0.0005; 149 6 9 (femoral) vs. 38 6 2 (blood) μmol/l, P , 0.0005] and higher in abdominal adipose tissue compared with femoral adipose tissue (P , 0.0005). Administration of GH induced an increase in interstitial glycerol in both abdominal and femoral adipose tissue (ANOVA: abdominal, P 5 0.04; femoral, P 5 0.03). There was no overall difference in the response to GH in the two regions during the study period as a whole (ANOVA: P 5 0.5), but during peak stimulation of lipolysis abdominal adipose tissue was, in absolute but not in relative terms, stimulated more markedly than femoral adipose tissue (ANOVA: P 5 0.03 from 45 to 225 min). Peak interstitial glycerol values of 253 6 37 and 336 6 74 μmol/l were seen after 135 and 165 min in femoral and abdominal adipose tissue, respectively. ATBF was not statistically different in the two situations (ANOVA: P 5 0.7). In conclusion, we have shown that a physiological pulse of GH increases interstitial glycerol concentrations in both femoral and abdominal adipose tissue, indicating activated lipolysis. The peak glycerol increments after GH were higher in abdominal adipose tissue, perhaps due to a higher basal rate of lipolysis in this region.
Evidence for an evolving cyclotron line energy in 4U 1538−522

We have performed a full time and luminosity-resolved spectral analysis of the high-mass X-ray binary 4U 1538−522 using the available RXTE, INTEGRAL, and Suzaku data, examining both phase-averaged and pulse-phase-constrained data sets and focusing on the behaviour of the cyclotron resonance scattering feature (CRSF). No statistically significant trend between the energy of the CRSF and luminosity is observed in the combined data set. However, the CRSF energy appears to have increased by ∼1.5 keV in the ∼8.5 yr between the RXTE and Suzaku measurements, with Monte Carlo simulations finding the Suzaku measurement 4. 6σ above the RXTE points. Interestingly, the increased Suzaku CRSF energy is much more significant and robust in the pulse-phase-constrained spectra from the peak of the main pulse, suggesting a change that is limited to a single magnetic pole. The seven years of RXTE measurements do not show any strongly significant evolution with time on their own. We discuss the significance of the CRSF's behaviour with respect to luminosity and time in the context of historical observations of this source as well as recent observational and theoretical work concerning the neutron star accretion column, and suggest some mechanisms by which the observed change over time could occur.
Educating Scholars of Practice: An Approach to Preparing Tomorrow's Researchers

SUMMARY Occupational therapy's scholarship too often fails to result in a cumulative body of knowledge that is directly relevant to practice, and links theory and research to practice. This problem has its basis in how therapists are prepared to make scholarly contributions to the field. This article describes an educational strategy for preparing scholars of practice whose work will contribute to building a knowledge base that examines and enhances practice. The strategy is based upon social learning theory, employs principles of situated learning and cognitive apprenticeship, and involves students as members of an ongoing community of scholars. Steps to and benefits of creating this scholarly community and implementing this educational strategy are discussed.
Rapid increase of serum anti‐MDA‐5 antibodies and exacerbation of clinically amyopathic dermatomyositis/interstitial lung disease

L. Dousset, C. Dutriaux, A. Ta€ıeb, F. Chibon, V. Foulongne, E. Frouin, M.L. Julli e, T. Jouary* Service de Dermatologie, Hopital Saint Andr e, CHU Bordeaux, Bordeaux, France, INSERM U916 Department of Pathology, Institut Bergoni e, Bordeaux, France, Laboratoire de Virologie, INSERM U1058, CHU de Montpellier, Universit e de Montpellier 1,Montpellier, Service d’Anatomie et de Cytologie Pathologiques, CHU de Poitiers, Poitiers, France, Service d’Anatomie Pathologique, Hôpital Haut-L evêque, Pessac, France *Correspondence: T. Jouary. E-mail: thomas.jouary@ch-pau.fr
Up‐regulated basigin‐2 in microglia induced by hypoxia promotes retinal angiogenesis

Retinal microglia cells contribute to vascular angiogenesis and vasculopathy induced by relative hypoxia. However, its concrete molecular mechanisms in shaping retinal angiogenesis have not been elucidated. Basigin, being involved in tumour neovasculogenesis, is explored to exert positive effects on retinal angiogenesis induced by microglia. Therefore, we set out to investigate the expression of basigin using a well‐characterized mouse model of oxygen‐induced retinopathy, which recapitulated hypoxia‐induced aberrant neovessel growth. Our results elucidate that basigin is overexpressed in microglia, which accumulating in retinal angiogenic sprouts. In vitro, conditioned media from microglia BV2 under hypoxia treatment increase migration and tube formation of retinal capillary endothelia cells, compared with media from normoxic condition. The angiogenic capacity of BV2 is inhibited after basigin knockdown by small interfering RNAs. A new molecular mechanism for high angiogenic capacity, whereby microglia cells release basigin via up‐regulation of PI3K‐AKT and IGF‐1 pathway to induce angiogenesis is unveiled. Collectively, our results demonstrate that basigin from hypoxic microglia plays a pivotal pro‐angiogenic role, providing new insights into microglia‐promoting retinal angiogenesis.
Phosphorylation of STAT3 in Undifferentiated Pleomorphic Sarcoma Is Correlated with a Favorable Prognosis

Objective: The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a role in various biological processes. Phosphorylated STAT3 (p-STAT3) functions as a transcriptional factor, and suppressor of cytokine signaling 3 (SOCS3) is a potential inhibitor of STAT3. Here, we analyzed the status of the JAK-STAT pathway in undifferentiated pleomorphic sarcoma (UPS). Methods: We performed immunohistochemistry in 79 samples of UPS and Western blotting in 10 frozen samples. We also examined alterations in protein expression in the JAK-STAT pathway after the inhibition of phosphorylated Akt (p-Akt) or extracellular signal-regulated kinase (p-Erk) in vitro. Results: Immunohistochemically, p-STAT3 and SOCS3 were positive in 59.7 and 55.8%, respectively. Positivity for p-STAT3 was significantly correlated with a better prognosis (p = 0.0006) and negatively with SOCS3 expression (p = 0.0223). Positivity for SOCS3 was significantly correlated with a worse prognosis (p = 0.0001). Western blotting analysis revealed that p-STAT3 expression was lower in tumor than in normal tissue. In vitro results demonstrated that there was no detectable change in the expression of p-STAT3 regardless of the status of p-Akt or p-Erk. Conclusion: p-STAT3 may be a useful prognostic factor for UPS.
Enhanced expression of heregulin in c‐erb B‐2 and c‐Ha‐ras transformed mouse and human mammary epithelial cells

Heregulin β1 was found to stimulate the anchorage‐dependent, serum‐free growth of nontransformed human MCF‐10A mammary epithelial cells. Unlike epidermal growth factor, transforming growth factor α, or amphiregulin, heregulin β1 was also able to induce the anchorage‐independent growth of MCF‐10A cells. In contrast, the anchorage‐dependent, serum‐free growth of c‐Ha‐ras or c‐erb B‐2 transformed MCF‐10A cells was unaffected by heregulin β1, whereas heregulin β1 was able to stimulate the anchorage‐independent growth of these cells. c‐Ha‐ras or c‐erb B‐2 (c‐neu) transformed MCF‐10A or mouse NOG‐8 mammary epithelial cells express elevated levels of 2.5, 5.0, 6.5, 6.8, and 8.5 kb heregulin mRNA transcripts and/or synthesize cell‐associated 25, 29, 50, and 115 kDa isoforms of heregulin. Since the MCF‐10A cells and transformants also express c‐erb B‐3, these data suggest that endogenous heregulin might function as an autocrine growth factor for Ha‐ras or erb B‐2 transformed mammary epithelial cells. © 1996 Wiley‐Liss, Inc. This article is a US Government work and, as such, is in the public domain in the United States of America.
Combining Previously Published Studies with Current Data in Bayesian Logistic Regression Model: An Example for Identifying Susceptibility Genes Related to Lung Cancer in Humans

A general analysis method is proposed that utilizes meta-analysis to incorporate similar studies in addition to our current investigation in order to obtain informative prior effect parameters in a logistic regression model. It is common in epidemiological studies that data from similar previous studies are available. The case of gene susceptibility association with increased lung cancer frequency was used to demonstrate this methodology. Results of Markov chain Monte Carlo (MCMC) iterations provided a more precise estimation of the regression coefficient in a logistic model with informative prior distribution compared to the noninformative prior distribution model. In situations where similar historical data are available, it is proposed to include as much relevant information as previously published results in the analysis of current data.
OX 1 Orexin/Hypocretin Receptor Signaling via Arachidonic Acid and Endocannabinoid Release

We have previously shown that OX 1 orexin receptor stimulation produces a strong 3 H-overflow response from [ 3 H]arachidonic acid (AA) -labeled cells. We have here attacked this issue with a more novel set of tools and methods to distinguish enzyme pathways responsible for this. Chinese hamster ovary-K1 (CHO-K1) cells, heterologously expressing human OX 1 receptors were used as a model system. Using selective pharmacological inhibitors, we can here show that in orexin-A-stimulated cells, the AA-derived radioactivity is released as two distinct components, free AA and the endocannabinoid 2-arachidonoyl glycerol (2-AG). Two orexin-activated enzymatic cascades are responsible for this, namely the Ca 2+ -sensitive phospholipase A 2 (cPLA 2 ) and diacylglycerol lipase (DAGL); the former cascade is responsible for a part of the AA release while the latter is fully responsible for 2-AG release and a part of the AA release. Interestingly, essentially only diacylglycerol released by phospholipase C but not by phospholipase D was implicated as a substrate for 2-AG production, although both phospholipases are strongly activated. The 2-AG released acted as a potent paracrine messenger via cannabinoid CB 1 receptors in an artificial cell − cell-communication assay developed. The cPLA 2 cascade, in contrast, was involved in the activation of the orexin receptor-operated Ca 2+ influx. 2-AG was also released upon OX 1 receptor stimulation in recombinant HEK-293 and neuro-2a cells. The results, for the first time, directly show that orexin receptors are able to, in addition to the arachidonic acid signaling, also generate potent endocannabinoid signals, which may explain the proposed orexin − cannabinoid interaction, e.g. in neurons.
Effects of chlorpyrifos on enzymatic systems of Cydia pomonella (Lepidoptera: Tortricidae) adults

The control program of codling moth (Cydia pomonella L.) in the Río Negro and Neuquén Valley is intended to neonate larvae. However, adults may be subjected to sublethal pesticide concentrations generating stress which might enhance both mutation rates and activity of the detoxification system. This study assessed the exposure effects of chlorpyrifos on target enzyme and, both detoxifying and antioxidant systems of surviving adults from both a laboratory susceptible strain (LSS) and a field population (FP). The results showed that the FP was as susceptible to chlorpyrifos as the LSS and, both exhibited a similar chlorpyrifos‐inhibitory concentration 50 (IC50) of acetylcholinesterase (AChE). The FP displayed higher carboxylesterase (CarE) and 7‐ethoxycoumarine O‐deethylase (ECOD) activities than LSS. Both LSS and FP showed an increase on CarE activity after the exposure to low‐chlorpyrifos concentrations, followed by enzyme inhibition at higher concentrations. There were no significant differences neither in the activities of glutathione S‐transferases (GST), catalase (CAT) and superoxide dismutase (SOD) nor in the reduced glutathione (GSH) content between LSS and FP. Moreover, these enzymes were unaffected by chlorpyrifos. In conclusion, control adults from the FP exhibited higher CarE and ECOD activities than control adults from the LSS. AChE and CarE activities were the most affected by chlorpyrifos. Control strategies used for C. pomonella, such as rotations of insecticides with different modes of action, will probably delay the evolution of insecticide resistance in FPs from the study area.