Miracle-dz/UniFAR-FTUs huggingface dataset:
KD 5170 , a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

Histone deacetylase (HDAC) inhibitors have garnered significant attention as cancer drugs. These therapeutic agents have recently been clinically validated with the market approval of vorinostat (SAHA, Zolinza) for treatment of cutaneous T-cell lymphoma. Like vorinostat, most of the small-molecule HDAC inhibitors in clinical development are hydroxamic acids, whose inhibitory activity stems from their ability to coordinate the catalytic Zn in the active site of HDACs. We sought to identify novel, nonhydroxamate-based HDAC inhibitors with potentially distinct pharmaceutical properties via an ultra-high throughput small molecule biochemical screen against the HDAC activity in a HeLa cell nuclear extract. An A-mercaptoketone series was identified and chemically optimized. The lead compound, KD5170, exhibits HDAC inhibitory activity with an IC50 of 0.045 Mmol/L in the screening biochemical assay and an EC50 of 0.025 Mmol/L in HeLa cell–based assays that monitor histone H3 acetylation. KD5170 also exhibits broad spectrum classes I and II HDAC inhibition in assays using purified recombinant human isoforms. KD5170 shows significant antiproliferative activity against a variety of human tumor cell lines, including the NCI-60 panel. Significant tumor growth inhibition was observed after p.o. dosing in human HCT-116 (colorectal cancer), NCI-H460 (non–small cell lung carcinoma), and PC-3 (prostate cancer) s.c. xenografts in nude mice. In addition, a significant increase in antitumor activity and time to endpoint occurred when KD5170 was combined with docetaxel in xenografts of the PC-3 prostate cancer cell line. The biological and pharmaceutical profile of KD5170 supports its continued preclinical and clinical development as a broad spectrum anticancer agent. [Mol Cancer Ther 2008;7(5):1054–65]
Mitigating Datacenter Incast Congestion Using RTO Randomization

TCP incast congestion happens in many-to-one communication workflow patterns that frequently arise in large-scale datacenter applications such as web search, social networks, and cluster-based storage systems. Incast congestion can severely degrade the performance of applications. This paper studies the effectiveness of randomizing the TCP retransmission timeout (RTO) in mitigating the impact of incast. Our design is based on the observation that under incast, retransmitted packets also get synchronized due to the use of similar RTOs by the senders. Using analysis and experimental evaluation, we show that there exists a tradeoff between the randomization interval (from which the RTO values are picked) and the number of senders involved in incast. Motivated by this insight, we propose three algorithms (TDA, MAA, and FSA) for the dynamic adaptation of the randomization interval that rely on (a) successive timeouts, (b) explicit knowledge of the level of multiplexing, and/or (c) the knowledge of flow sizes (i.e., large interval for long flows and a small interval for short flows), respectively. Our results show that these algorithms improve goodput by 1.5x-11x for up to 64 senders and provide greater improvement for larger number of senders. The proposed algorithms can be readily deployed as they do not require any changes in switches or applications.
Determinants of business intelligence system acceptance in an emerging country

How to cite this paper: Kgasago, K. J. O. , & Jokonya, O. (2018). Determinants of business intelligence system acceptance in an emerging country. Journal of Governance & Regulation, 7(4), 42-50. http://doi.org/10.22495/jgr_v7_i4_p5 Copyright © 2018 The Authors This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) http://creativecommons.org/licenses/by-
Exposure of children and adolescents to alcohol advertising on Australian metropolitan free-to-air television.

AIM This study investigated the exposure of underage youth to alcohol television advertising on metropolitan free-to-air television in the five mainland capital city markets of Australia. DESIGN Exposure levels (target audience rating points; TARPs) were obtained for all alcohol advertisements screened from November 2005 to October 2006 in each capital city market for: children 0-12 years; underage teens 13-17 years; young adults 18-24 years; and mature adults 25+ years. The 30 most exposed advertisements across age groups were then content-analysed for elements appealing to children and underage youth. RESULTS In each of the five metropolitan markets, mature adults were most exposed to alcohol advertising. Children were exposed to one-third the level of mature adults and underage teens to approximately the same level as young adults. However, there was considerable variation in media weight between markets, such that underage teens in two markets had higher advertising TARPs than young adults in other markets. All 30 highest exposed advertisements contained at least one element known to appeal to children and underage youth, with 23 containing two or more such elements. Fifteen of the 30 advertisements featured an animal. CONCLUSIONS The self-regulation system in Australia does not protect children and youth from exposure to alcohol advertising, much of which contains elements appealing to these groups.
Fibroblast growth factor regulation of neovascularization

Purpose of reviewFibroblast growth factors are potent angiogenic inducers; however, their precise roles in angiogenesis have not been well understood. In this review, we will focus on specific roles played by fibroblast growth factors in neovascularization. Recent findingsAlthough fibroblast growth factors promote a strong angiogenic response, it has been suggested that FGF-induced angiogenesis requires activation of the vascular endothelial growth factor system. Recent findings have endorsed the view of indirect contribution of fibroblast growth factor signaling to vascular development. A study using embryoid bodies demonstrated a nonimmediate role played by fibrobalst growth factor receptor 1 in vasculogenesis as vascular endothelial growth factor supplementation was sufficient to promote vascular development in Fgfr1−/− embryoid bodies. Moreover, another line of evidence indicated that myocardial fibroblast growth factor signaling is essential for mouse coronary development. The key role of fibroblast growth factor signaling in this process is Hedgehog activation, which induces vascular endothelial growth factor expression and formation of the coronary vasculature.In addition to vascular endothelial growth factor interaction, fibroblast growth factors can control neovascularization by influencing other growth factors and chemokines such as platelet-derived growth factor, hepatocyte growth factor and monocyte chemoattractant protein-1, contributing to development of mature vessels and collateral arteries. SummaryAlthough fibroblast growth factors are potent angiogenic factors, they may indirectly control neovascularization in concert with other growth factors. Thus, the unique role played by fibroblast growth factors might be organization of various angiogenic pathways and coordination of cell–cell interactions in this process.
Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism

In this study we report a convergence of behavioural and neuroanatomical evidence in support of an amygdala hypothesis of autism. We find that people with high-functioning autism (HFA) show neuropsychological profiles characteristic of the effects of amygdala damage, in particular selective impairment in the recognition of facial expressions of fear, perception of eye-gaze direction, and recognition memory for faces. Using quantitative magnetic resonance (MR) image analysis techniques, we find that the same individuals also show abnormalities of medial temporal lobe (MTL) brain structure, notably bilaterally enlarged amygdala volumes. These results combine to suggest that developmental malformation of the amygdala may underlie the social-cognitive impairments characteristic of HFA. This malformation may reflect incomplete neuronal pruning in early development.
Unusual location of a blue nevus: development on the lacrimal punctum

A 73-year-old Japanese woman was referred to our department for evaluation of a pigmented lesion on her left lower eyelid. She had been aware of the lesion for a few months. Physical examination revealed a blue-black nodule, approximately 3.2 mm in diameter, located on the lacrimal punctum of the lower left eyelid (figure 1A). Dermoscopic observation showed homogeneous blue-blackish pigmentation with regular vessels on its surface and blue-whitish veil-like structures around the lacrimal punctum. [. ]
Steroid hormone alteration of herpes simplex virus type 1 replication

The effect of steroid hormones on herpes simplex virus type 1 replication was examined. Virus replication studies revealed that various concentrations of prednisolone, hydrocortisone, dexamethasone, or progesterone could decrease virus yields up to a maximum of 99%. Using isopycnic centrifugation in CsCl to separate viral from cell DNA, it was found that virus‐specific DNA synthesis was decreased by 30 to 100% depending on the hormone and concentration used. Cell‐specific DNA synthesis was also adversely affected, but this did not alter cell viability or plating efficiency.
Accounting information and dividend payout prediction in Nigerian listed manufacturing firms

Investors’ curiosity on the worth of their investment could be resolved with the availability of sufficient information in predicting their returns and security. Several studies linked dividend payout to the performance of manufacturing firms in Nigeria but a few considered information as a signal to performance not necessarily to dividend. This paper examined the usefulness of accounting information in predicting the investors return especially dividend payout. Ex-post facto design was adopted using secondary data obtained from annual reports and accounts of 36 selected manufacturing firms for a period of 20 years (1997-2016). The results of the regression (fixed effects) analysis carried out revealed that lagged dividend, leverage and sales growth have significant positive effect on dividend payout while earnings per share, operating cash-flow and firm size influences dividend payout ratio negatively with the exemption of asset utilization ratio with insignificant effect. It is evident that accounting information is useful to investors’ in predicting the returns on their investment and dividend payout. Investors should look beyond past dividend in forecasting expected returns but several factors as presented in the financial statements in taking informed investment decisions. Key words: Accounting information, lagged dividend, asset utilization, returns prediction, investment.
ECRG1, a Novel Candidate of Tumor Suppressor Gene in the Esophageal Carcinoma, Triggers a Senescent Program in NIH3T3 Cells

Esophageal cancer–related gene 1 (ECRG1) is a novel tumor-suppressor gene candidate identified from the human esophagus. Previous studies showed that ECRG1 overexpression could inhibit cell growth and induce G1 cell cycle arrest and p15INK4b expression by interacting with Miz-1 (Myc-interacting zinc finger protein). Such evidence suggests the alterations in ECRG1 may play an important role in tumorigenesis. To further study the biological function of the ECRG1 gene, we transfected ECRG1 into NIH3T3 cells. Expression of ECRG1 in these cells caused senescence-like changes characterized in terms of altered cell morphology, cell cycle arrest at the G1/S phase, and significantly impaired cell proliferation (P < 0.01). Moreover, NIH3T3 cells transfected with ECRG1 stained positive for SA-β-gal staining (pH 6.0), which is a specific marker of cellular senescence. We also studied changes in telomerase activity and the related senescence genes, such as p21 and p16. The results indicated that when ECRG1 induced a senescence-like state, telomerase activity was markedly decreased (P < 0.05), and expression of p21 was distinctly increased, whereas no changes were detected in p16 and telomerase-component RNA levels. These findings suggest that ECRG1 may be of importance in murine ceil senescence, promoting senescence by regulating expression of p21.
Serum antibody reactive with predominant organisms in the subgingival flora of young adults with generalized severe periodontitis

In the present study we sought to determine whether serum antibody was present against microorganisms which predominate in the subgingival flora of young adults with generalized severe periodontitis (SP). Subjects with SP were often seropositive for Eubacterium brachy, Fusobacterium nucleatum E3C22, and Peptostreptococcus micros, whereas subjects with juvenile periodontitis (JP) and subjects with healthy periodontium (HP) were not. Both SP and JP subjects were more frequently seropositive for Bacteroides gingivalis, F. nucleatum D52B16, and F. nucleatum E1D1 than were HP subjects. The data were most striking for B. gingivalis, for which both the incidence and the magnitude of specific antibody was clearly elevated for SP and JP subject groups. However, SP subjects generally had either a high antibody titer or no detectable titer. In contrast, JP and HP subjects generally had at least very small amounts of antibody. Except at very low levels of antibody, neither SP nor JP groups differed significantly from the HP group for antibody to Eubacterium nodatum, Bacteroides intermedius (homology group 4197 or 8944), or Lactobacillus minutus antibody. There was a high frequency of antibody to E. nodatum, with very high titers in all groups despite the fact that this organism is rarely found in HP subjects. For Eubacterium timidum, the JP group was clearly more frequently seropositive than the HP group. Despite high levels of L. minutus in subgingival flora, none of the 50 SP subjects had a detectable antibody titer, and only four of the HP and JP subjects had detectable antibody. These results indicate that many organisms in the subgingival flora elicit antibody responses. B. gingivalis is probably the best example among the species tested. However, some organisms that are present in high concentration, e.g., L. minutus, apparently fail to induce significant antibody responses.
Segregation and Coactivation of Developing Neocortical Layer 1 Neurons

Layer 1 in the developing cerebral cortex is populated by two basic neuronal cell types, Cajal–Retzius (CR) cells and non-CR cells. We generated transgenic mice in which green fluorescent protein (GFP) was driven by the promoter of metabotropic glutamate receptor subtype 2 and expressed specifically in CR cells during cortical development. On the basis of the precise identification of CR cells with GFP fluorescence, we pursued developmental changes and synaptic mechanisms of both CR and non-CR cells during the postnatal period. Immunostaining in combination with GFP fluorescence imaging showed that GFP and reelin, a protein involved in corticogenesis, completely overlap in CR cells at postnatal day 0. At the subsequent postnatal stage, reelin-positive neurons are segregated and categorized into GFP-positive/GABA-negative CR cells and GFP-negative/GABA-positive non-CR cells. Individual and simultaneous whole-cell recordings of CR and non-CR cells in developing cerebral slices revealed that spontaneous and electrically evoked postsynaptic currents (sPSCs and ePSCs) measured in CR and non-CR cells are differentially mediated by GABAA receptors versus GABAA, AMPA, and NMDA receptors, respectively. Furthermore, CR and non-CR cells show synchronized repetitive barrages of sPSCs that reflect a network-driven activity in the developing cerebral cortex. These findings imply that the layer 1 neurons dynamically change and play a distinct and integral role in the postnatal developing neocortex.
Development of the SP machine

This paper describes the main things that need to be done to develop the "SP machine", based on the "SP theory of intelligence" and its realisation in the "SP computer model". The SP machine may be developed initially as a software virtual machine with high levels of parallel processing, hosted on a high-performance computer, or driven by high-parallel search processes in any of the leading search engines. An easy-to-use user interface is needed with facilities for visualisation of knowledge structures and processing. The system needs to be generalised to work with patterns in two dimensions, including the display of multiple alignments with 2D patterns. Research is needed into how the system may discover low-level features in speech and visual images. Existing strengths of the SP system in the processing of natural language may be developed towards the understanding of natural language and its production from meanings. This may be done most effectively in conjunction with the development of existing strengths of the SP system in unsupervised learning. Existing strengths of the SP system in pattern recognition may be developed for computer vision. Further work is needed on the representation of numbers and the performance of arithmetic processes in the SP system. A computer model is needed of SP-neural drawing on the existing conceptual model. When the SP machine is relatively mature, new hardware may be developed to exploit opportunities to increase the efficiency of computations. There is potential for the SP machine to be applied on relatively short timescales in such areas as information storage and retrieval, with intelligence, software engineering with or without automation or semi-automation, and information compression.
Transient hyperopic refractive changes in newly diagnosed juvenile diabetes.

PURPOSE To investigate transient hyperopic refractive changes in newly diagnosed juvenile diabetics and to evaluate their clinical course after starting intensive glycemic control of severe hyperglycaemia. METHODS 20 hyperopic adolescents with newly diagnosed and uncomplicated type 1 diabetes, selected for this prospective study, were enrolled for a baseline examination and, after starting intensive insulin treatment, followed every two weeks during a four-month follow up. Standardised automated refraction and A-mode ultrasonography were performed. Poor metabolic control was an inclusion criteria. RESULTS Refractive changes and hyperopic peaks preceded the start of the intensive insulin therapy in all diabetics and, thereafter, refraction decreased gradually with a maximum recovery time of 94 days. A statistically significant positive correlation between refractive changes and magnitude of plasma glucose concentrations as well as HbA1c percentages was observed (P <0.001). No significant modifications in the explored refractive components were recorded. CONCLUSIONS Transient hyperopic changes are highly dependent on the magnitude of plasma glucose concentrations and rapid correction of hyperglycemia is strictly correlated with complete recovery of refraction. To account for this phenomenon, the sorbitol production via the polyol pathway with overhydration of the lens remains the best pathophysiological hypothesis at this time.
PENGARUH MODAL KERJA TERHADAP PROFITABILITAS PERUSAHAAN (STUDI KASUS PADA PERUSAHAAN YANG GO PUBLIC DI BURSA EFEK INDONESIA)

Working capital management involves defining the working capital policy and the implementation of those policies in their daily operations. Working capital policy refers to the basic policy company regarding the targeted amount for each category of current assets and how the current assets would be financed. The purpose of this study was to determine the effect of working capital on profitability in companies that go public in Indonesia Stock Exchange Case Study at PT Semen Baturaja (Persero) Tbk, in this case using a variable inventory turnover and accounts receivable turnover. The first hypothesis testing results obtained 0.691 results concluded that the inventory turnover not significantly affect the Return on Assets (ROA). Results of testing the second hypothesis obtained results concluded 0.615 receivable turnover significantly affect the Return on Assets (ROA).
Hearing threshold levels and speech recognition in noise in 7-year-olds

International standards define normal hearing threshold levels (HTLs) and many studies describe speech recognition in noise (SRN) for adults. Less has been published on these characteristics for children. This study aims to establish ranges of HTLs and SRN for otologically normal 7-year-olds. Air conduction HTLs were measured in 189 7-year-olds within an audiometric booth. Speech recognition was measured adaptively for BKB sentences in noise presented binaurally through headphones, determining the speech-to-noise ratio (SNR) required to score 71% correct. The mean HTLs of otologically normal 7-year-olds were significantly lower (better) than those published for young adults at 1 and 2 kHz. Speech recognition in noise was unrelated to HTLs and was higher (worse) for 7-year-olds (SNR = − 4 dB) than has been found for young otologically normal adults (SNR = − 6 dB). It is concluded that although the HTLs of 7-year-old children are generally better than those of young adults, their speech recognition in noise is worse. This confirms that their ability to recognise speech in noise is not fully developed at this age.
Levels and distribution of polybrominated diphenyl ethers in various tissues of foraging hens from an electronic waste recycling area in South China

Levels and distribution of polybrominated diphenyl ethers (PBDEs) in various tissues of hens foraging near an electronic wastes stack spot in Taizhou, China, were studied. With high‐resolution gas chromatography/negative chemical ionization mass spectrometry analysis, 37 PBDE congeners from di‐ to hepta‐brominated and BDE 209 were identified and quantified in the liver, heart, skin, fat, intestine, muscle, blood, oviduct, ovum, gizzard, spleen, and kidney tissues of hens. Based on lipid weight in all analyzed tissues, muscle exhibited the highest PBDE concentrations (17,977 ng/g lipid wt), BDE 209 was the dominant congener, and the sum of quantified PBDEs followed the order muscle > fat > intestine > heart > liver > oviduct > gizzard > blood > skin > ovum. Principal component analysis results indicated that the hen muscle tissue was characterized by BDE 32, 209, 28, and 75 congeners; hen intestine, heart, and blood tissues were characterized by BDE 153, 99, 183, 138, 154, 47, and 100 congeners; and hen skin, liver, oviduct, ovum, gizzard, spleen, kidney, and fat tissues had a similar PBDE congener profile. The present study also indicated that the PBDE congeners were persistent enough to accumulate through the human food chain and that deca‐BDE might be potential risk to ecoenvironment.