Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of inertia and turbulence on rheological measurements of neutrally buoyant suspensions

For low-Reynolds-number shear flows of neutrally buoyant suspensions, the shear stress is often modelled using an effective viscosity that depends only on the solid fraction. As the Reynolds number ( $Re$ ) is increased and inertia becomes important, the effective viscosity also depends on the Reynolds number itself. The current experiments measure the torque for flows of neutrally buoyant particles in a coaxial-cylinder rheometer for solid fractions, $\unicode[STIX]{x1D719}$ , from 10 % to 50 % and Reynolds numbers based on particle diameter from 2 to 1000. For experiments for Reynolds of $O(10)$ and solid fractions less than $30\,\%$ , the effective viscosity increases with Reynolds number, in good agreement with recent numerical simulations found in the literature. At higher solid fractions over the same range of $Re$ , the results show a decrease in torque with shear rate. For Reynolds numbers greater than 100 and lower solids concentrations, the effective viscosity continues to increase with Reynolds number. However, based on comparisons with pure fluid measurements the increase in the measured effective viscosity results from the transition to turbulence. The particles augment the turbulence by increasing the magnitude of the measured torques and causing the flow to transition at lower Reynolds numbers. For the highest solid fractions, the measurements show a significant increase in the magnitude of the torques, but the effective viscosity is independent of Reynolds number.
Role of robotics in the management of secondary ureteropelvic junction obstruction

Patients with recurrent ureteropelvic junction obstruction (UPJO) present a treatment dilemma to urologists. Second‐line therapies have previously been shown to fail at a higher rate than the initial therapeutic procedure. We report our experience with robotic‐assisted, dismembered pyeloplasty in patients with secondary UPJO.
Developmental changes in troponin T isoform expression and tension production in chicken single skeletal muscle fibres.

1. The Ca2+ sensitivity of tension development was characterized in single skinned fibres from the slow anterior latissimus dorsi (ALD), fast posterior latissimus dorsi (PLD), and fast pectoralis major (PM) muscles of the chicken at adult and neonatal (2 weeks post‐hatch) stages of development. In the adult, the PM was most sensitive, the ALD intermediate, and the PLD least sensitive to Ca2+. 2. PM and PLD fibres were less sensitive to Ca2+ at the neonatal stage of development than in the adult. However, ALD fibres exhibited no age‐dependent changes in Ca2+ sensitivity. 3. Characterization of regulatory protein composition indicated that the PM and PLD fibres had identical fast isoforms of troponin C and troponin I at each developmental stage examined, but there were muscle‐specific and age‐dependent expressions of troponin T isoforms in these fibres. 4. In the ALD fibres, identical slow isoforms of troponin C, troponin I and tropomyosin were found at each stage. In addition, the troponin T isoform that was present did not change with age. 5. The results suggest a relationship between the specific troponin T isoform composition of individual muscle fibres and their calcium sensitivities of tension development.
Variable Deficiencies in the Interferon Response Enhance Susceptibility to Vesicular Stomatitis Virus Oncolytic Actions in Glioblastoma Cells but Not in Normal Human Glial Cells

ABSTRACT With little improvement in the poor prognosis for humans with high-grade glioma brain tumors, alternative therapeutic strategies are needed. As such, selective replication-competent oncolytic viruses may be useful as a potential treatment modality. Here we test the hypothesis that defects in the interferon (IFN) pathway could be exploited to enhance the selective oncolytic profile of vesicular stomatitis virus (VSV) in glioblastoma cells. Two green fluorescent protein-expressing VSV strains, recombinant VSV and the glioma-adapted recombinant VSV-rp30a, were used to study infection of a variety of human glioblastoma cell lines compared to a panel of control cells, including normal human astrocytes, oligodendrocyte precursor cells, and primary explant cultures from human brain tissue. Infection rate, cell viability, viral replication, and IFN-α/β-related gene expression were compared in the absence and presence of IFN-α or polyriboinosinic polyribocytidylic acid [poly(I:C)], a synthetic inducer of the IFN-α/β pathway. Both VSV strains caused rapid and total infection and death of all tumor cell lines tested. To a lesser degree, normal cells were also subject to VSV infection. In contrast, IFN-α or poly(I:C) completely attenuated the infection of all primary control brain cells, whereas most glioblastoma cell lines treated with IFN-α or poly(I:C) showed little or no sign of protection and were killed by VSV. Together, our results demonstrate that activation of the interferon pathway protects normal human brain cells from VSV infection while maintaining the vulnerability of human glioblastoma cells to viral destruction.
Neural Network-based Graph Embedding for Cross-Platform Binary Code Similarity Detection

The problem of cross-platform binary code similarity detection aims at detecting whether two binary functions coming from different platforms are similar or not. It has many security applications, including plagiarism detection, malware detection, vulnerability search, etc. Existing approaches rely on approximate graph-matching algorithms, which are inevitably slow and sometimes inaccurate, and hard to adapt to a new task. To address these issues, in this work, we propose a novel neural network-based approach to compute the embedding, i.e., a numeric vector, based on the control flow graph of each binary function, then the similarity detection can be done efficiently by measuring the distance between the embeddings for two functions. We implement a prototype called Gemini. Our extensive evaluation shows that Gemini outperforms the state-of-the-art approaches by large margins with respect to similarity detection accuracy. Further, Gemini can speed up prior art's embedding generation time by 3 to 4 orders of magnitude and reduce the required training time from more than 1 week down to 30 minutes to 10 hours. Our real world case studies demonstrate that Gemini can identify significantly more vulnerable firmware images than the state-of-the-art, i.e., Genius. Our research showcases a successful application of deep learning on computer security problems.
The Use of a Surgical Patch Coated With Human Coagulation Factors in Surgical Routine: A Multicenter Postauthorization Surveillance

Local hemostyptic agents are of great value to significantly reduce bleeding complications and various devices have become available for clinical use. The aim of this multicenter postauthorization surveillance was to study the surgeons’ expectations regarding efficacy and safety of the surgical patch coated with human coagulation factors (TachoSil) under routine clinical conditions. A total of 408 patients had been included in this trial and the patients had to have an expected increased bleeding risk either due to patient related hemorrhagic risk factors or operations associated with an expected increase of bleeding complications. The main types of surgical interventions were operations on the liver (26%), vascular system (16%), gastrointestinal tract (10%), heart (8%), kidney (7%), thorax (7%), spleen (4%), and pancreas (4%). Other operations (18%) were reported in the fields of neurosurgery, urology, gynecology, dermatology, and on the thyroid gland. Based on subjective assessments the results have shown that TachoSil has met the surgeons’ expectations to be efficacious and safe as a hemostatic treatment in a broad variety of surgical interventions. The observed benefits far exceed the frequencies of complications and many of the observed benefits easily translate into cost savings. In almost 50% of the cases the surgeons thought that the use of the topical hemostat TachoSil may have led to savings in blood component therapy. The savings of intra- and postoperative transfusions may lead to less frequent transfusion-related adverse effects and the lower probability of postoperative complications is of clinical importance. In particular, it is worth mentioning that based on the surgeons’ assessment, the use of TachoSil may have helped to save the organ in 17% of the cases. Thus, these clinically relevant benefits may offer opportunities for improvements of hemostasis in patients at risk for bleeding complications and may facilitate the management of excessive bleeding.
Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk.

BACKGROUND A T-to-G polymorphism (SNP309) at the promoter region of MDM2 has been recently reported to extend the Sp1 binding site that positively regulates the MDM2 transcription level and consequently, its expression level. MDM2 is the negative regulator of p53 tumor suppressor protein and elevated levels of MDM2 hamper the stress response driven by the p53 pathway. Whether MDM2-SNP309 was associated with breast cancer as a predisposing factor was investigated. PATIENTS AND METHODS A case-control study of 223 females diagnosed with breast cancer and 149 female controls sampled from the Turkish population was carried out and the T/G MDM2-SNP309 genotype of participants was determined. RESULTS There was no significant association of the G/G or G/T genotypes with breast cancer risk (odds ratio (OR) 1.14, 95% confidence interval (CI) 0.59-2.22, and OR 1.20, 95% CI 0.67-2.12, respectively). Stratification of the data for onset age or for menopausal status at the time of diagnosis also revealed no association for either group.
The potential impact of prophylaxis against bronchiolitis due to the respiratory syncytial virus in children with congenital cardiac malformations

Aims: To determine the number of infants in the Mersey and North West regions with congenital cardiac disease for whom palivizumab may be appropriate, and to examine the potential impact of introducing prophylaxis with palivizumab on these patients and their economic management. Methods: We identified those infants deemed to be at high risk, matching the population recently studied by the Cardiac Synagis Group, from the database of the cardiology department of the hospital. The number of patients under the care of the paediatric cardiologists admitted to Alder Hey Hospital with respiratory syncytial viral bronchiolitis over the last three seasons was identified from hospital coding records, and the database of the cardiology department. Results: There are 131 patients at high risk each year. Of these, over the last three “bronchiolitis seasons”, 39 infants have been admitted to the hospital with bronchiolitis due to the respiratory syncytial virus. This represents a hospitalisation rate of 10 per cent, as was seen in the study of the Cardiac Synagis Group. Using a monthly dose of 15 milligrams per kilogram for five doses, the cost per patient is 2,650 pounds sterling for the season. To treat the 131 patients seen at Alder Hey, therefore, would cost 346,800 pounds each year. Applying the reductions in hospitalisation identified in the study by the Cardiac Synagis Group to our population would produce an expected reduction in patients hospitalised from 13 to 7 per year, reducing the total length of stay in our hospital wards from 169 to 76 days, and in the paediatric intensive care unit from 93 to 21 days. This amounts to a potential saving of 190,800 pounds per year. Reducing transfers to more distant paediatric intensive care units for referrals refused because of lack of beds could save an additional 50,000 pounds. Discussion: We estimate the net cost of introducing palivizumab for this population to be 106,000 pounds per year. There would, of course, be additional costs involved in setting up this service, as well as additional savings and benefits. This cost is comparable with other new biologic therapies now routinely used in the United Kingdom, such as etanercept for juvenile arthritis. There are, currently, no other obvious therapies that have the potential to reduce admissions to hospital and intensive care during the winter months, when beds are at their most scarce.
Leading the flock: organ donation feelings, beliefs, and intentions among African American clergy and community residents.

CONTEXT Despite a considerable potential role in organ donation for African American clergy, there has been little investigation to date of the beliefs, attitudes, and personal intentions of such clergy regarding donation. OBJECTIVE To compare the beliefs, attitudes, and behavioral intentions regarding organ donation among African American clergy to those of African American residents of the same large US city. DESIGN Focus groups and 3 cross-sectional surveys. SETTING Greater Houston, Tex, metropolitan area. PARTICIPANTS A total of 761 randomly selected African American community residents and 311 African American clergy. MAIN OUTCOMES MEASURES Beliefs about the importance of organ donation; how comfortable one is in thinking about donation; whether one believes that organ donation is against one's religion; trust in healthcare professionals regarding death declaration; concerns that donation leads to body mutilation; and the likelihood that one will donate one's own organs upon death. RESULTS Compared to general African American residents, African American clergy in the Houston area were found more often to believe in the importance of donation; to be more comfortable with thinking about donation; to feel more certain that donation was not against their religion; to believe that they could trust healthcare professionals regarding death declaration; to feel less often that donation leads to mutilation of the body; and to indicate a greater likelihood of donating their own organs upon death. The same was found to be true among clergy and congregants of the largest religious denomination in Houston, the Baptists.
Displacement Sensor Based on Diamond-Shaped Tapered Split Ring Resonator

Split-ring resonators (SRRs) are ideal structures for the realization of compact high-sensitivity and high-resolution sensors due to their high-quality factor resonance, compact size, and high sensitivity to changes in the constituent materials and physical dimensions. This paper presents a displacement sensor based on a diamond-shaped tapered SRR coupled to a coplanar waveguide. Two significant improvements over previous designs are reported. Firstly, the proposed sensor has higher dynamic range and linearity for displacement sensing. Secondly, compared with previous designs, where the displacement changes both the resonant frequency and depth of the transmission notch, the proposed sensor has a fixed resonant frequency. This is an important improvement since the sensor can be operated at a single fixed frequency and bypass the need for a frequency-sweeping microwave source and measurement system such as an expensive network analyzer. It is shown that, while preserving the compact size, the proposed sensor also benefits from a lower operating frequency. The design principle and simulation results are validated through measurement.
Inflation Forecasting Using Machine Learning Methods

Inflation forecasting is an important practical problem. This paper proposes a solution to this problem for Russia using several basic machine learning methods: LASSO, Ridge, Elastic Net, Random Forest, and Boosting. Despite the fact that these methods already existed in the early 2000s, for a long time they remained almost unnoticed in the professional literature related to the forecasting of inflation in general, and Russian inflation in particular. This paper is one of the first attempts to apply machine learning methods to the forecasting of inflation in Russia. The present empirical study demostrates that the Random Forest model and the Boosting model are at least as good at inflation forecasting as more traditional models, such as Random Walk and autoregression. The main result of this paper is the confirmation of the possibility of more accurate forecasting of inflation in Russia using machine learning methods.
A noninvasive estimation of mixed venous oxygen saturation using near‐infrared spectroscopy by cerebral oximetry in pediatric cardiac surgery patients

Background : Near‐infrared spectroscopy (NIRS) is a noninvasive optical monitor of regional cerebral oxygen saturation (rSO2). The aim of this study was to validate the use of NIRS by cerebral oximetry in estimating invasively measured mixed venous oxygen saturation (SvO2) in pediatric postoperative cardiac surgery patients.
Increased absolute light sensitivity in Himalayan mice with cold-induced ocular pigmentation

Controversy over the relationship between ocular pigmentation and absolute dark-adapted light sensitivity has persisted for over two decades. Previous electrophysiological experiments in hypopigmented mammals (mice, rats, rabbits) show increased thresholds in the dark-adapted state proportional to the deficit in ocular melanin. Animals with the least amount of ocular melanin have the most elevated thresholds. Dark-adapted thresholds in hypopigmented mice show similar threshold elevations in behavioral tests. The present study extends these findings to show that a specific increase in ocular pigmentation results in the converse effect, lowered absolute dark-adapted thresholds. The increase in ocular melanin was accomplished by keeping Himalayan mice in the cold (4°C) for 6 weeks. Himalayan mice (C57BL/6J cH/cH) were compared to black mice (C57BL/6J +/+) and albino mice (C57BL/6J c2J/c2J) after 6 weeks at either 4°C or 20°C in 12-h cycling light (<1 cd/m2). The Himalayan mice that were kept in the cold exhibited a 44% increase in ocular melanin compared to Himalayan mice kept at room temperature. Cold rearing did not effect ocular melanin or visual thresholds in control animals (black mice = 10−5.9 cd/m2 and albino mice = 10−4.4 cd/m2). In contrast, the Himalayan mice maintained at 4°C had thresholds of 10−5.7 cd/m2 compared to 10−5.1 cd/m2 for Himalayan mice kept at 20°C. This represents compelling evidence of a direct relationship between ocular melanin concentration and absolute dark-adapted light sensitivity.
Levulan ® : the first approved topical photosensitizer for the treatment of actinic keratosis

Actinic keratosis (AK) is a very common skin problem found in patients over 50 years of age, representing an in situ keratinocytic neoplasm that can progress to invasive squamous cell carcinoma of the skin. One Food and Drug Administration-approved treatment for AK of the face and scalp is photodynamic therapy (PDT) with 20% aminolevulinic acid (ALA). This advanced technology has been demonstrated in clinical trials to be effective and well tolerated by patients.
Structure of O‐glycosidically linked oligosaccharides synthesized by the insect cell line Sf9

The O‐glycosidically linked Oligosaccharides on the pseudorabies virus (PRV) glycoprotein gp50 synthesized by three different cell lines were studied. The intact membrane protein (gp50) was expressed in Vero cells and in the insect cell line Sf9. In addition, a truncated, secreted form lacking the transmembrane and cytoplasmic domains (gp50T), was expressed in CHO and Sf9 cells. The protein, both in intact and truncated form, synthesized by the two mammalian cells contained only the disaccharide Galβ1‐3GalNAc, either unsubstituted or substituted with one or tow sialic acid residues. By contrast, the major O‐linked structure on gp50 and gp50T synthesized by Sf9 cells was the monosaccharide GalNAc. The Sf9 cells also linked lower amounts of Galβ1‐3GalNAc to gp50 (12%) and gp50T (26%). None of the structures synthesized by Sf9 cells contained sialic acid. Measurements of the two relevant glycosyltransferases revealed that while all three cell lines contain comparable levels of the UDP‐GalNAc:polypeptide, N‐acetylgalactosaminyltransferase activity, there is a greater variation in the levels of UDP‐Gal: N‐acetylgalactosamine, β1‐3 galactosyltransferase, with the Sf9 cells containing the lowest level.
A Rapid Ethnography of Itinerant Teachers of the Deaf

A rapid ethnographic study of 10 itinerant teachers in two school districts and 21 other professionals working with the itinerants was conducted. Rapid ethnography starts with the same assumptions about culture as conventional ethnography. However, it is not constrained by the assumption of cultural ignorance on the investigator's part. Thus, it enables better-directed data collection. Interviews with the itinerants and other professionals, direct observation of itinerants at work, and archival data permitted the authors to generate a list of themes reflecting results of other studies which focused on specific skills for itinerant teaching. While knowledge of specific skills cannot be ignored, the study shows that effective itinerants are ones who, through a personality trait, extensive experience, or a specific value system, can generate a positive composite image of their role as itinerants and are then able to interact on the basis of that image.
The Effect of Kurosaka Screw Divergence on the Holding Strength of Bone-Tendon-Bone Grafts

Fresh-frozen porcine knees were used to demonstrate the effects of diverging Kurosaka screw placement on linear load to failure in simulated anterior cruciate liga ment reconstructions. Screws, placed anteromedially (rear-entry or tibial type) or intraarticularly (endoscopic femoral type) into each tibia, were directed at 0°, 15°, or 30° divergence angles relative to a guide wire. Grafts were axially loaded to failure to determine holding strength. Hierarchical analysis of variance was used to analyze differences between tibial side and endoscopic femoral type screw placement and the angles of diver gence. Overall, the difference in pullout strength be tween rear-entry (or tibial side) and endoscopic femoral type fixation was shown to be statistically significant (P < 0.001). Anteromedially placed screws showed a sta tistically significant decrease in holding strength at 15° and 30° compared with 0° of divergence (P < 0.05). Intraarticular screw placement resulted in a statistically significant decrease in holding strength only at 30° of divergence (P < 0.05). This study supports the impor tance of accurate screw placement within the tibia to ensure optimal interference fixation and suggests that endoscopic screw placement may offer significant added security when there are minor degrees of divergence.