Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of aromatherapy in relieving symptoms related to job stress among nurses.

Workplace-related stress has become today's most serious occupational hazard. Aromatherapy is a simple, convenient and non-invasive method of stress relief. There is little research regarding the efficacy of aromatherapy by means of inhaling essential oil in reducing workplace stress-related symptoms among nurses. Therefore, this study was to examine the effectiveness of lavender oil inhalation in reducing job stress-related symptoms among nurses. The 53 nurses in the experimental group pinned small bottles containing 3% lavender oil on the clothes of their right chests, whereas 57 participants in the control group pinned bottles with no lavender oil. Aromatherapy was shown to be effective in the reduction of the number of stress symptoms for 3 or 4 days. The stress symptoms of the experimental group decreased from 6.1 to 2.8 after aromatherapy was carried out (P = 0.126, 0.159, 0.035 and 0.026). This represented a significant decrease in stress, whereas the stress symptoms in the control group increased from 5.6 to 5.8. Hospital staff managers are still encouraged to include aromatherapy concepts and techniques in the continuing education of nursing staff. Concurrently, future research should focus on the possible side effects of aromatherapy to assure safety.
Chemical composition and cytotoxicity of extracts of marjoram and rosemary and their activity against Sporothrix brasiliensis

Purpose. Motivated by increasing reports of antifungal resistance in human and animal sporotrichosis, this study evaluated the chemical composition, cytotoxicity and anti‐Sporothrix brasiliensis activity of extracts of marjoram (Origanum majorana) and rosemary (Rosmarinus officinalis). Methodology. Ten (INF10) and 60 min (INF60) infusions, a decoction and a hydroalcoholic extract (HAE, 70%) were prepared from both plants (10% w/v). The extract composition was analysed by liquid chromatography/mass spectrometry and the cytotoxicity was evaluated using a colorimetric assay in canine and feline kidney cells. Using a broth microdilution assay (CLSI M38‐A2) adapted to the extracts, 30 Sporothrix brasiliensis isolates from dogs, cats and humans, and one Sporothrix schenckii were tested. Results/Key findings. The predominant phenolic compounds found in all extracts were 4‐hydroxybenzoic acid, caffeic acid and chlorogenic acid. Luteolin was also one of the predominant compounds, but only in the HAE of marjoram. Extracts of marjoram maintained cell viability in concentrations up to 2.5 mg ml−1 for the feline cell line and up to 10 mg ml−1 for the canine cell line, whereas in rosemary, the cell viability for both kidney lines was maintained with concentrations up to 5 mg ml−1. The activity of rosemary extracts was low or absent. Among the marjoram extracts, HAE was highlighted and had fungistatic activity against Sporothrix brasiliensis (MIC5040 mg ml−1), including in all itraconazole‐resistant isolates. S. schenckii sensu stricto was sensitive to marjoram extracts (MIC/MFC ≤5 mg ml−1), with the exception of INF10. Conclusion. These findings support the potential usefulness of the HAE of marjoram in the treatment of sporotrichosis.
Identification of endo-beta-N-acetylglucosaminidase and N-acetylmuramyl-L-alanine amidase as cluster-dispersing enzymes in Staphylococcus aureus

Two proteins which are capable of dispersing cell clusters of Staphylococcus aureus have been purified from a S. aureus FDA209P culture supernatant. Both of them were found to have bacteriolytic activity. From the elution profile of column chromatography and Western blot (immunoblot) analysis, one of them was identified as a 51-kDa endo-beta-N-acetylglucosaminidase (GL). The other was a 62-kDa protein on the basis of sodium dodecyl sulfate gel electrophoresis. Analysis of the peptidoglycan fragments following treatment with the 62-kDa protein indicated that this protein is an N-acetylmuramyl-L-alanine amidase (AM). In vitro studies of cluster dispersion activities using S. aureus mutant strains Lyt66 or S. aureus Wood46 grown as clusters demonstrated that these two enzymes act synergistically to disperse clusters into single cells. Antiserum against the 51-kDa GL cross-reacted with the 62-kDa AM, and S. aureus FDA209P grown in the presence of anti-51-kDa-GL immunoglobulin G induced giant clusters. Clusters induced by anti-51-kDa GL and by Cibacron blue F3G-A were dispersed by coincubation with the 51-kDa GL and the 62-kDa AM. Western blot analysis demonstrated that the 51-kDa GL and the 62-kDa AM were missing in culture supernatants of S. aureus Lyt66, Wood46, and RUSAL2 (Tn551 autolysin-defective mutant), which grow in clusters. These results strongly suggest that the 51-kDa GL and 62-kDa AM are involved in cell separation of daughter cells after cell division.
A Comparison of Fully-Coupled 3D In-Stent Restenosis Simulations to In-vivo Data

We describe our fully-coupled 3D multiscale model of in-stent restenosis, with blood flow simulations coupled to smooth muscle cell proliferation, and report results of numerical simulations performed with this model. This novel model is based on several previously reported 2D models. We study the effects of various parameters on the process of restenosis and compare with in vivo porcine data where we observe good qualitative agreement. We study the effects of stent deployment depth (and related injury score), reendothelization speed, and simulate the effect of stent width. Also we demonstrate that we are now capable to simulate restenosis in real-sized (18 mm long, 2.8 mm wide) vessel geometries.
Growth Behavior of Meta-Stable ${\rm NiSn}_{3}$ Intermetallic Compound and Its Potential Influence on the Reliability of Electronic Components

The morphology, texture evolution and growth behavior of the meta-stable <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> intermetallic compound (IMC) in Sn electrodeposits over Ni were investigated. It was found that at lower storage temperatures <formula formulatype="inline"> <tex Notation="TeX">$({<}100^{\circ}{\rm C})$</tex></formula>, the plate-like <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> is the dominant IMC phase in the Sn layers. Upon raising the temperature, a competition between the initiations of <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> and <formula formulatype="inline"><tex Notation="TeX">${\rm Ni}_{3}{\rm Sn}_{4}$</tex></formula> phases was observed as identified by energy dispersive X-ray. The crystal structure of <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> was determined by the powder diffraction pattern. The investigations revealed that the growth rate of <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> in terms of the penetration depth from the Sn/Ni interface to the Sn surface follows the square-root power law, implying a diffusion controlled phase growth. The diffusion coefficients of the <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> phase growth were determined at different temperatures (25<formula formulatype="inline"><tex Notation="TeX">$^{\circ}{\rm C}$</tex></formula>, 50<formula formulatype="inline"><tex Notation="TeX">$^{\circ}{\rm C}$</tex></formula>, and 75<formula formulatype="inline"> <tex Notation="TeX">$^{\circ}{\rm C}$</tex></formula>), which are significantly higher than that reported for <formula formulatype="inline"><tex Notation="TeX">${\rm Ni}_{3}{\rm Sn}_{4}$</tex></formula> under the same temperatures. The activation energy for the growth of <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> obtained is 39.90 kJ/mol. Hardness and Young's modulus of <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> were determined by means of nanoindentation. This paper discusses the potential influences of the <formula formulatype="inline"><tex Notation="TeX">${\rm NiSn}_{3}$</tex></formula> phase growth on the reliability of electronic components containing Ni–Sn diffusion couple.
Loa loa: development and course of patency in experimentally-infected primates.

Loa loa infections were studied in baboons, rhesus and patas monkeys. Animals were infected either by s.c. injection of third-stage larvae (L 3) or by surgical implantation of juvenile worms of known age, sex and number. Microfilaremia was first detected in baboons at 140 days following inoculation of L 3 and at 142 days and 143 days in patas and rhesus monkeys, respectively; the mean prepatent period was 151 days in baboons, 149 days in patas monkeys and 169 days in rhesus monkeys. The primary wave of microfilariae (mf) was suppressed by the spleen in all three primate species. In baboons, the initial wave of mf lasted from 11 to 46 weeks (mean: 22 weeks), whereas in patas monkeys it persisted for 47 to 60 weeks, and in rhesus monkeys for 1 to 2 years. Gross and microscopical changes in the spleen were noted in all three primate species and consisted of numerous granulomata in the red pulp underlying the capsule. A resurgence of mf was observed following splenectomy in all three species of monkeys. Postsplenectomy levels of microfilaremia typically exceeded presplenectomy levels. One pair of worms was sufficient to produce patent infections in monkeys for extended periods of time. However, levels of microfilaremia were lower than in monkeys which received 75 and 200 to 300 L 3, although some overlap in microfilaremias between groups did occur. Overall, there was no proportional relationship between levels of microfilaremia and numbers of adult worms recovered from monkeys at necropsy. It was observed that, in the primate host, Loa is a long-lived parasite. Living worms were recovered from the tissues as long as 9 years after inoculation and there was no reason to doubt that patency would have persisted for some time into the future. Adult worms were frequently observed moving freely in the subcutaneous tissues of the primate hosts, although no instance of Calabar swellings or the presence of worms in or around the eye were ever recorded. The primate model of loiasis is an especially useful system because of the predictability of the behavior of the parasite. In most regards, the behavior of L. loa in the primate host is comparable to observations on the parasi e in man. (ABSTRACT TRUNCATED AT 400 WORDS)
Market risk and returns: Evidence from the Nigerian capital market

The relationship between markets returns proxied by ‘betas’ and security returns is well established in the relevant extant literature. The objective of this paper is to provide evidence that this relationship holds in the Nigerian Capital Market. The study specifically examines market risk as defined in the Capital Asset Pricing Model (CAPM) as an explanatory variable for security returns in the Nigerian Capital Market. The model was tested with quarterly data for the period 2001 to 2005, using the most capitalized firms in the Nigerian Capital market. The findings confirm a positive linear relationship between market betas and security returns for the sampled Nigerian firms.
Validation Test of Geant4 Simulation of Electron Backscattering

Backscattering is a sensitive probe of the accuracy of electron scattering algorithms implemented in Monte Carlo codes. The capability of the Geant4 toolkit to describe realistically the fraction of electrons backscattered from a target volume is extensively and quantitatively evaluated in comparison with experimental data retrieved from the literature. The validation test covers the energy range between approximately 100 eV and 20 MeV, and concerns a wide set of target elements. Multiple and single electron scattering models implemented in Geant4, as well as preassembled selections of physics models distributed within Geant4, are analyzed with statistical methods. The evaluations concern Geant4 versions from 9.1 to 10.1. Significant evolutions are observed over the range of Geant4 versions, not always in the direction of better compatibility with experiment. Goodness-of-fit tests complemented by categorical analysis tests identify a configuration based on Geant4 Urban multiple scattering model in Geant4 version 9.1 and a configuration based on single Coulomb scattering in Geant4 10.0 as the physics options best reproducing experimental data above a few tens of keV. At lower energies only single scattering demonstrates some capability to reproduce data down to a few keV. Recommended preassembled physics configurations appear incapable of describing electron backscattering compatible with experiment. With the support of statistical methods, a correlation is established between the validation of Geant4-based simulation of backscattering and of energy deposition.
Prevalence of Antimicrobial Drug Resistance of Klebsiella pneumoniae in India

Klebsiella pneumoniae has been associated with different types of infections and one of the most important aspects of Klebsiella is the emergence of multi-drug resistant strains particularly those involved in nosocomial diseases. Fifty - nine clinical isolates were collected from different parts of India. Most of the samples were recovered from respiratory, urinary tract infection and pus cases which were followed by biochemical characterization. Twenty confirmed K. pneumoniae isolates were further tested for antimicrobial drug sensitivity and almost fifty percent of them were found to be multidrug resistant. As per our statistical data, all confirmed K.pneumoniae isolates were resistant to carbenicillin and one among them recovered from sputum sample of a pneumonic patient was resistant to all the antimicrobial agents tested except exhibiting a partial susceptibility to amikacin. In our studies we found that K.pneumoniae strains from clinical cases were highly susceptible to quinolones and the aminoglycoside, amykacin and gentamycin. At the same time over 60 % strains were resistant to chloramphenicol and tetracycline. We also found that 28 to 76 % of them were resistant to cephalosporins (ceftizoxime and cefotaxime). On the basis of statistical binomial test we conclude that piperacillin, carbenicillin, ofloxacine ampicillin, co-trimoxazole and chloramphenicol were significantly resistant, whereas cefotaxime and tetracycline were found to be moderately resistant against Klebsiella pneumoniae.
Behaviours of pulmonary sensory receptors during development of acute lung injury in the rabbit

We tested the hypothesis that oleic acid‐induced acute lung injury activates pulmonary nociceptors, that is, C fibre receptors (CFRs) and high‐threshold Aδ fibre receptors (HTARs). Single‐unit activity was recorded in the cervical vagus nerve and assessed before and after injecting oleic acid (75 μl kg−1i.v.) into anaesthetized, open‐chest, mechanically ventilated rabbits. Unit activities increased within seconds and peaked within a few minutes (from 0.3 ± 0.1 to 1.4 ± 0.9 impulses s−1 for CFRs and from 0.5 ± 0.1 to 1.7 ± 0.3 impulses s−1 for HTARs, both n= 8 and P < 0.05). These activities were sustained while pulmonary oedema developed and dynamic lung compliance decreased over the 90 min observation period. Activities in slowly adapting receptors and rapidly adapting receptors were also increased; however, their responsiveness to airway pressure stimulation decreased progressively. We conclude that pulmonary nociceptors are stimulated during acute lung injury. The dual nociceptor system, consisting of both non‐myelinated CFRs and myelinated HTARs, may play an important role in the pathophysiological process of acute lung injury‐induced respiratory responses.
Potential of wormwood (Artemisia absinthium) as a feed supplement in rabbit diet: effect on controlling rabbit coccidiosis, antioxidative systems and growth performance

the objective of the study was the investigation of dietary inclusion of Artemisia absinthium as a potential anticoccidial drug in rabbit diet, as well as a growth promoter and antioxidant in rabbit nutrition. the in vivo investigation was carried out on 120 male New Zealand white rabbits. the rabbits were distributed into four dietary treatments with ten replicates each. two levels of whole wormwood plant were used: 100 g/kg (WW100) and 200 g/kg (WW200). the control treatment (C) was basal diet, and one treatment (Cr) received chemical coccidiostat robenidine, supplemented in the amount of 6 g/kg. the rabbits were given ad libitum access to water and feed throughout the entire trial period. Feed intake was measured on a daily basis, while body weight was monitored at an individual level during the entire experimental period every seven days, for a total of 77 days. Blood and liver samples were collected for enzyme analyses, where oocyst counts were determined in 1 g of rabbit feces. at the end of the trial, the addition of 200 g/kg of wormwood led to the highest body weight (3047 g), as well to the lowest feed conversion ratio (3.20 kg/kg) with significant differences compared to the control treatment (3.75 kg/kg). The highest recorded glutatione reductase value was with treatment WW100, with significant differences to other experimental treatments. Consumption of coccidiostat and dried wormwood plant in different levels led to a notably lower malondialdehyde content in liver homogenate compared to the control treatment. Finally, the lowest number of oocysts was found in the treatment receiving wormwood in a concentration of 100 g/kg. On the basis of the results achieved, it may be noticed that wormwood supplementation in the diet of rabbits has a positive influence on growth performance, as well on antioxidative systems in rabbits. Subsequently, it was shown that wormwood can successfully be used in reducing the number of oocysts in rabbits.
Path-constrained motion planning for multi-manipulator systems

The paper presents a systematic approach to the minimum-energy collision-free motion planning of many redundant manipulators along prescribed paths. It is based on using a parametric-decomposition method and a negative formulation of the Pontryagin Maximum Principle which handles efficiently various control and/or state constraints imposed on the manipulators' motions, which arise naturally out of joint limits and obstacle avoidance. In contrast to the penalty-function method, the proposed algorithm does not require an initial admissible solution and finds trajectories of a smaller cost than those generated by the penalty-function approach. A computer example involving two planar redundant manipulators of three revolute kinematic pairs is included to illustrate the discussed ideas.
Implementation and Outcomes of a Rapid Response Team

Adverse events in hospitalized patients are preceded by clinical signs of decline. Thus, early recognition and intervention should improve patient outcomes. At the University of Kentucky Hospital, the impetus to start a rapid response team (RRT) was to decrease unplanned admissions to ICU, adverse events, and mortality overall. On the basis of the outcomes at our hospital, we conclude that there is benefit to having an RRT. The following article outlines processes for RRT implementation and our outcomes to date.
Design of an IoT-BIM-GIS Based Risk Management System for Hospital Basic Operation

There has been a significant increase in emergency incidents involving hospital basic operation (non-clinical side of hospital daily running and maintaining), which adversely affects the functioning of hospitals and poses threat to the staff members and patients. To cope with these emergencies, our group proposes a design of risk management system based on technologies of Internet of Things (IoT), building information model (BIM), and geographic information system (GIS), aiming to realize real-time risk factors identification and more effective and more efficient coordinated response. In this paper, the system architecture, key technologies, and simulated cases are also presented respectively.
Atomic force microscopy characterization of supported planar bilayers that mimic the mitochondrial inner membrane

In this study we examined the properties of supported planar bilayers (SPBs) formed from phospholipid components that comprise the mitochondrial inner membrane. We used 1‐palmitoyl‐2‐oleoyl‐sn‐glycero‐ 3‐phosphocholine (POPC), 1‐palmitoyl‐2‐oleoyl‐sn‐glycero‐3‐phosphoethanolamine (POPE) and cardiolipin (CL). Liposomes of binary POPE:POPC (1:1, mol:mol) and ternary (POPE:POPC:CL (0.5:0.3:0.2, mol:mol:mol) composition were used in the formation of SPBs on mica. The characterization of the SPBs was carried out below (4°C) and above (24 and 37°C) the phase transition temperature (Tm) of the mixtures in solution. We observed: (i) that the thickness of the bilayers, calculated from a cross‐sectional analysis, decreased as the visualization temperature increased; (ii) the existence of laterally segregated domains that respond to temperature in SPBs of POPE:POPC:CL; (iii) a decrease in height and an increase in roughness (Ra) of SPBs after cytochrome c (cyt c) injection at room temperature. To obtain further insight into the nature of the interaction between cyt c and the bilayers, the competition between 8‐anilino‐1‐naphthalene sulfonate (ANS) and the protein for the same binding sites in liposomes was monitored by fluorescence. The results confirm the existence of preferential interaction of cyt c with CL containing liposomes. Taking these results and those of previous papers published by the group, we discuss the preferential adsorption of cyt c in CL domains. This provides support for the relevance of these phospholipids as a proton trap in the oxidative phosphorylation process that occurs in the energy transducing membranes. Copyright © 2007 John Wiley & Sons, Ltd.
Prevalence of canine parvovirus infection at different pet clinics in Lahore, Pakistan.

Prevalence of canine parvovirus (CPV) infection was studied in the dog population of Lahore. A total of 198 fecal samples were taken aseptically from dogs clinically suspected for parvovirus infection from different pet clinics of Lahore during 2010-2011. Most animals had a history of hemorrhagic diarrhoea, vomiting and a few had yellow diarrhea with mucus. Cases were categorized and recorded on the basis of sex, age and breed. Fecal samples were processed for haemagglutination test (HAT) and slide agglutination test (SAT) for CPV antigen. The overall prevalence of CPV was 22.7 % (45/198). It was observed that CPV was more prevalent in the 0-2 month age group (44.5%), dogs of the German shepherd breed were more susceptible (40%), and female dogs were more at risk (58.5%). The cardiac form of the disease was noted in young puppies while the enteric form of the disease was noted in both puppies and in young dogs. Tissue samples were collected in 10% formalin for histological study of heart and intestinal tissue. In the cardiac form there was a severe to mild loss of myofibres, sarcolemmal proliferation, and intranuclear inclusion bodies while in the enteric form a complete loss of intestinal villi, compaction of the lamina propria with dilated crypts and a lack of leucocytes were observed. The results showed that SAT is a cheap and rapid screening test for the diagnosis of CPV infection. It is suggested that dogs should be vaccinated against CPV in order to eradicate this life threatening disease of dogs from Pakistan.