Miracle-dz/UniFAR-FTUs huggingface dataset:
An update on quality control for the PFA-100/PFA-200

Abstract Testing of platelet function comprises a crucial element of hemostasis assessment, particularly for investigations into bleeding and/or bruising. The Platelet Function Analyzer (PFA)-100 is the most utilized primary hemostasis-screening test system available, as recently remodeled/upgraded to the PFA-200. Internal quality control (IQC) and external quality assessment (EQA) (including proficiency testing) represent critical elements of ensuring test practice quality. Although true for all tests, IQC and EQA are logistically challenging for platelet function testing, inclusive of the PFA-100/200. We accordingly update our experience with novel yet feasible approaches to both IQC and EQA of PFA-100/200. Over the past 10 years, a total of 43 challenges have been tested, with most challenges designed to mimic moderate or severe primary hemostasis defects. The current report is restricted to the last four years and has also differentially assessed PFA-100 vs. PFA-200 EQA results to identify potential variance. Numerical results for closure times (CTs) and participant-supplied interpretive comments were analyzed. Reported CTs for each challenge were within limits of expectation, and good reproducibility was evidenced by repeated challenges. Coefficients of variation (CVs) for challenges, generally ranging from 15% to 25%, were similar or better than those obtained using native whole blood and consistent with past reports. Participant interpretations were generally consistent with test data and expectations. There was no evident difference in PFA-100 vs. PFA-200 EQA test results. The EQA material has also been successfully evaluated from the perspective of potential IQC. To conclude, IQC and EQA processes for the PFA-100/200 have been established that are highly reproducible, supporting the concept of EQA/IQC for platelet function testing, and also facilitating monitoring and improvement in its performance. In terms of EQA, PFA-100 and PFA-200 instruments appear to behave similarly.
Counting Compositions over Finite Abelian Groups

We find the number of compositions over finite abelian groups under two types of restrictions: (i) each part belongs to a given subset and (ii) small runs of consecutive parts must have given properties. Waring's problem over finite fields can be converted to type~(i) compositions, whereas Carlitz and locally Mullen compositions can be formulated as type~(ii) compositions. We use the multisection formula to translate the problem from integers to group elements, the transfer matrix method to do exact counting, and finally the Perron-Frobenius theorem to derive asymptotics. We also exhibit bijections involving certain restricted classes of compositions.
Regulation of Gene Expression by 1 a , 25-Dihydroxyvitamin D 3 and Its Analog EB 1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells

Analogs of 1a,25-dihydroxyvitamin D3 (1a, 25(OH)2D3) inhibit growth in vitro and in vivo of cells derived from a variety of tumors. Here, we examined the effects of 1a,25(OH)2D3 and its analog EB1089 on proliferation and target gene regulation of human head and neck squamous cell carcinoma (SCC) lines SCC4, SCC9, SCC15, and SCC25. A range of sensitivities to 1a,25(OH)2D3 and EB1089 was observed, from complete G0/G1 arrest of SCC25 cells to only 50% inhibition of SCC9 cell growth. All lines expressed similar levels of vitamin D3 receptor (VDR) mRNA and protein, and no significant variation was observed in 1a,25(OH)2D3-dependent induction of the endogenous 24-hydroxylase gene, or of a transiently transfected 1a,25(OH)2D3sensitive reporter gene. The antiproliferative effects of 1a,25(OH)2D3 and EB1089 in SCC25 cells were analyzed by screening more than 4,500 genes on two cDNA microarrays, yielding 38 up-regulated targets, including adhesion molecules, growth factors, kinases, and transcription factors. Genes encoding factors implicated in cell cycle regulation were induced, including the growth arrest and DNA damage gene, gadd45a, and the serumand glucocorticoid-inducible kinase gene, sgk. Induction of GADD45a protein in EB1089-treated cells was confirmed by Western blotting. Moreover, while expression of proliferating cell nuclear antigen (PCNA) was reduced in EB1089-treated cells, coimmunoprecipitation studies revealed increased association between GADD45a and PCNA in treated cells, consistent with the capacity of GADD45a to stimulate DNA repair. While 1a,25(OH)2D3 and EB1089 modestly induced transcripts encoding the cyclin-dependent kinase inhibitor p21, no changes in protein levels were observed, indicating that p21 induction does not contribute to the antiproliferative effects of 1a,25(OH)2D3 and EB1089 in SCC cells. Finally, in partially resistant SCC9 cells, there was extensive loss of target gene regulation (10 of 10 genes tested), indicating that resistance arises from widespread loss of 1a,25(OH)2D3-dependent gene regulation in the presence of normal levels of functional VDRs. (Molecular Endocrinology 15: 1127– 1139, 2001)
Physical factors and biological interactions regulating infauna in shallow boreal areas

Infauna, including all post-larval stages, were quantitatively sampled from 1977 to 1984 in a shallow (< 1 m) unvegetated, semi-exposed soft bottom area, situated on the Swedish west coast. Variations in the infaunal abundance, biomass and production are shown to be the result of temperature conditions and predator-prey interactions. Temperature is considered to be an important physical factor causing annual and seasonal variations in spat recruitment, biomass and survival over the winter. During the post-recruitment period, infaunal abundances are mainly controlled by intraand interspecific competition, particularly the predation of mobile epibenthic animals. Intraand interspecific interactions between adult bivalves and spat, as demonstrated in experimental studies, showed that high adult surv~val inhibited spat recruitment. In the absence of ovenvintered adults, spat survival increased. Interspecific interactions between adult bivalves showed that late-arriving species are able to eliminate older established species. The importance of physical factors, e.g. exposure, water depth and currents, in determining variations in the abundance, biomass and production of infauna, is also discussed. Results suggest that both abiotic factors and biological interactions are important regulating mechanisms for infaunal densities in shallow unvegetated boreal areas.
Caractérisation des systèmes de cacaoculture agro-forestiers dans la zone de front pionnier du Centre Cameroun

Le Centre Cameroun est le principal bassin de production du pays. En raison de la forte pression fonciere qui caracterise certaines zones comme la Lekie, des mouvements migratoires sont apparus au debut des annees 80 vers le Mbam et Kim ou de nombreux exploitants sont alles a la conquete de nouvelles terres pour creer leurs vergers de cacaoyers. En 2003, une etude a ete menee dans cette zone de «front pionnier» ou 287 exploitations agricoles ont ete enquetees afin de caracteriser leur systeme de production et leur systeme de cacaoculture. Les resultats de cette etude permettent aujourd'hui de disposer de nombreuses informations sur les caracteristiques des systemes de cacaoculture dans cette region d'extension du verger de cacaoyers. Ils montrent que les pratiques des exploitants du Mbam et Kim quelque peu differentes de celles adoptees dans le reste du Centre Cameroun. Si les systemes de cacaoculture, du type agro-forestier, sont globalement peu differents de ceux mis en oeuvre dans les autres zones forestieres ou la cacaoculture s'est developpee des le debut du XXeme siecle, de nouvelles pratiques sont cependant mises en oeuvre en zone de front pionnier. (Resume d'auteur)
Risk Factors for Groin Injury and Groin Symptoms in Elite‐Level Soccer Players: A Cohort Study in the Dutch Professional Leagues

• BACKGROUND: Groin injury and groin symptoms are common in soccer players. The relationship of groin injury and groin symptoms to reduced hip range of motion (ROM) and previous injury is unclear. • OBJECTIVES: To conduct a retrospective assessment of associations between previous injury and preseason hip ROM and preseason prevalence of severe groin symptoms, and to prospectively identify risk factors for within‐season groin injury. • METHODS: During the period of 2015 to 2016, 190 players from 9 Dutch professional soccer clubs participated in this cohort study with prospective and retrospective elements. Univariate and multivariate logistic regressions were used to predict preseason severe groin symptoms, identified using the Copenhagen Hip and Groin Outcome Score, from a history of previous groin injury, general injury (minimum of 1 week in duration) in the previous season, and hip ROM. Cox regression was used to predict within‐season groin injury. • RESULTS: Point prevalence of severe groin symptoms was 24% and within‐season incidence of groin injury was 11%. Total, training, and match groin injury incidences were 0.5, 0.2, and 2.6 injuries per 1000 playing hours, respectively. A history of more than 1 previous groin injury was associated with current severe groin symptoms (odds ratio = 3.0; 95% confidence interval: 1.0, 8.3; P = .038). General injury sustained in the previous season (ankle, knee, thigh, shoulder; median, 9 weeks of time loss) was a risk factor for groin injury (hazard ratio = 5.1; 95% confidence interval: 1.8, 14.6; P = .003). • CONCLUSION: Severe injuries in the previous season to locations other than the groin increase the risk of groin injury the next season. A history of groin injury is associated with current severe groin symptoms. Preseason hip ROM does not identify players at risk for groin injury. • LEVEL OF EVIDENCE: Prevention, level 2b. • KEY WORDS: football (soccer), groin pain, hip range of motion, injury prevention
Learning Classifiers with Fenchel-Young Losses: Generalized Entropies, Margins, and Algorithms

This paper studies Fenchel-Young losses, a generic way to construct convex loss functions from a regularization function. We analyze their properties in depth, showing that they unify many well-known loss functions and allow to create useful new ones easily. Fenchel-Young losses constructed from a generalized entropy, including the Shannon and Tsallis entropies, induce predictive probability distributions. We formulate conditions for a generalized entropy to yield losses with a separation margin, and probability distributions with sparse support. Finally, we derive efficient algorithms, making Fenchel-Young losses appealing both in theory and practice.
Incidental Category Learning and Cognitive Load in a Multisensory Environment Across Childhood

Multisensory information has been shown to facilitate learning (Bahrick & Lickliter, 2000; Broadbent, White, Mareschal, & Kirkham, 2017; Jordan & Baker, 2011; Shams & Seitz, 2008). However, although research has examined the modulating effect of unisensory and multisensory distractors on multisensory processing, the extent to which a concurrent unisensory or multisensory cognitive load task would interfere with or support multisensory learning remains unclear. This study examined the role of concurrent task modality on incidental category learning in 6- to 10-year-olds. Participants were engaged in a multisensory learning task while also performing either a unisensory (visual or auditory only) or multisensory (audiovisual) concurrent task (CT). We found that engaging in an auditory CT led to poorer performance on incidental category learning compared with an audiovisual or visual CT, across groups. In 6-year-olds, category test performance was at chance in the auditory-only CT condition, suggesting auditory concurrent tasks may interfere with learning in younger children, but the addition of visual information may serve to focus attention. These findings provide novel insight into the use of multisensory concurrent information on incidental learning. Implications for the deployment of multisensory learning tasks within education across development and developmental changes in modality dominance and ability to switch flexibly across modalities are discussed.
Effect of increasing levels of raw and extruded narrow-leafed lupinseeds in broiler diet on performance parameters, nutrient digestibility and AME N value of diet

The growing interest in cultivation and the introduction of legume seeds into animal and poultry diets has been observed in recent years. It was shown that biologically active legume proteins, rich in lysine, have antioxidant properties (Nalle et al., 2011; Smulikowska et al., 2013; Kaczmarek et al. 2014; Hejdysz et al. 2015, 2016a,b; Rutkowski et al., 2015, 2017). Antioxidants (such as selenium and vitamin E) and microelements (Zn, Cu, Mn) supporting the immune system are among other beneficial components of legume seeds (Wasilewko and Buraczewska, 1999; Lampart-Szczapa and Łoza, 2007). Antinutritional factors present in seeds such as protease inhibitors, alkaloids, α-galactosides and tannins limit inclusion levels of legume seeds in diets, especially for young, growing animals (Smulikowska et al., 1999; Laudadio and Tufarelli, 2011b). ABSTRACT. In the first study conducted to investigate the nutritional value of raw and extruded narrow-leafed lupin (Lupinus angustifolius) seeds cv. Boruta, 60 male Ross 308 chickens of age 16–20 days were used (Experiment 1). In 35-day performance trial (Experiment 2), 960 1-day-old chickens were randomly allotted to 11 treatments and fed diets containing 0, 50, 100, 200, 250 or 300 g · kg−1 diet of raw or extruded narrow-leafed lupin seeds. In the first experiment, extrusion of narrow-leafed lupin seeds led to the decrease of neutral detergent fibre (NDF) concentration. Seed processing increased fat digestibility and nitrogen retention in chickens but had no effect on ileal digestibility of protein and amino acids. There was a tendency to increase the apparent metabolizable energy corrected to zero N balance (AMEN) after lupin extrusion. In the second experiment, the inclusion of increasing levels of raw or extruded seeds into diets quadratically decreased body weight gains (BWGs) of birds, except for broilers fed extruded lupin on days 15–35. The extrusion increased the BWGs of birds in the whole trial period (days 0–35). Increasing levels of raw and extruded narrow-leafed lupin seeds quadratically increased feed conversion ratio during the experiment. So, the extrusion of narrow-leafed lupin seeds had a limited positive effect on the chemical composition of seeds and growth performance of broiler chickens. Received: 29 August 2017 Revised: 20 November 2017 Accepted: 1 February 2018
Correlation between the state of periodontal tissues and selected cardiovascular parameters in patients with type 2 diabetes

Introduction: t ype 2 diabetes and periodontitis are chronic diseases with a two-way interrelation - ship. Periodontitis is a chronic inflammatory disease increasing the risk of cardiovascular complica- tions. Aim of the study: t o assess the impact of the state of periodontal tissues on selected cardiovascular parameters in patients with type 2 diabetes. Material and methods: the study included 84 patients with type 2 diabetes who were treated at the Clinical Department of internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital of the Ministry of interior in warsaw. the patients had the following parameters determined: periodontal pocket depth, clinical attachment loss, plaque index, bleeding index, iMt, LVMi and systemic arterial pressure. Results: the periodontal status of patients treated for type 2 diabetes was unsatisfactory, high values of periodontal parameters were observed. in a follow-up observation after one year, the clinical condition of periodontium was significantly deteriorated. there were correlations between the number of teeth and clinical attachment loss on the one hand and iMt on the other hand (p < 0.05). Conclusions: Periodontitis in patients with type 2 diabetes may impact an increase of iMt (inti- ma-media thickness), which confirms the association between periodontitis and cardiovascular diseases.
Charge dynamics and spin blockade in a hybrid double quantum dot in silicon

Electron spin qubits in silicon, whether in quantum dots or in donor atoms, have long been considered attractive qubits for the implementation of a quantum computer because of silicon’s “semiconductor vacuum” character and its compatibility with the microelectronics industry. While donor electron spins in silicon provide extremely long coherence times and access to the nuclear spin via the hyperfine interaction, quantum dots have the complementary advantages of fast electrical operations, tunability, and scalability. Here, we present an approach to a novel hybrid double quantum dot by coupling a donor to a lithographically patterned artificial atom. Using gate-based rf reflectometry, we probe the charge stability of this double quantum-dot system and the variation of quantum capacitance at the interdot charge transition. Using microwave spectroscopy, we find a tunnel coupling of 2.7 GHz and characterize the charge dynamics, which reveals a charge T2 of 200 ps and a relaxation time T1 of 100 ns. Additionally, we demonstrate a spin blockade at the inderdot transition, opening up the possibility to operate this coupled system as a singlet-triplet qubit or to transfer a coherent spin state between the quantum dot and the donor electron and nucleus.
Partial (Neighbourhood) Singleton Arc Consistency for Constraint Satisfaction Problems

Algorithms based on singleton arc consistency (SAC) show considerable promise for improving backtrack search algorithms for constraint satisfaction problems (CSPs). The drawback is that even the most efficient of them is still comparatively expensive. Even when limited to preprocessing, they give overall improvement only when problems are quite difficult to solve with more typical procedures such as maintained arc consistency (MAC). The present work examines a form of partial SAC and neighbourhood SAC (NSAC) in which a subset of the variables in a CSP are chosen to be made SAC-consistent or neighbourhood-SAC-consistent. Such consistencies, despite their partial character, are still well-characterized in that algorithms have unique fixpoints. Heuristic strategies for choosing an effective subset of variables are described and tested, the best being choice by highest degree and a more complex strategy of choosing by constraint weight after random probing. Experimental results justify the claim that these methods can be nearly as effective as the corresponding full version of the algorithm in terms of values discarded or problems proven unsatisfiable, while significantly reducing the effort required to achieve this.
Laterality and Gender in Congenital Upper Limb Deficiencies

Laterality and gender in congenital upper limb deficiencies have been an area of debate in prosthetics for many years. Images such as the ‘Limbless children, Moscow’ in 1993 by Gerd Ludwig in the National Geographic showed a line of 8 children, all with left sided congenital upper limb deficiency. The line consisted of 6 girls and two boys. Did this picture depict what has been considered by the experts to be true when it comes to congenital upper limb deficiencies – It is more common on the left side and more common in females? (Figure 1).
A unified sweep-stick mechanism to explain particle clustering in two- and three-dimensional homogeneous, isotropic turbulence

Our work focuses on the sweep-stick mechanism of particle clustering in turbulent flows introduced by Chen et al. [L. Chen, S. Goto, and J. C. Vassilicos, “Turbulent clustering of stagnation points and inertial particles,” J. Fluid Mech. 553, 143 (2006)] for two-dimensional (2D) inverse cascading homogeneous, isotropic turbulence (HIT), whereby heavy particles cluster in a way that mimics the clustering of zero-acceleration points. We extend this phenomenology to three-dimensional (3D) HIT, where it was previously reported that zero-acceleration points were extremely rare. Having obtained a unified mechanism we quantify the Stokes number dependency of the probability of the heavy particles to be at zero-acceleration points and show that in the inertial range of Stokes numbers, the sweep-stick mechanism is dominant over the conventionally proposed mechanism of heavy particles being centrifuged from high vorticity regions to high strain regions. Finally, having a clustering coincidence between particles and.
Rating Methods for Proactive Recommendation on Smartwatches

This paper analyzes possible interaction methods for using a recommender system on a smartwatch. As prerequisite, we describe interaction patterns currently used by Android Wear applications. Based on a prototype implementation the interaction methods action buttons, two button card and swipes are compared against each other. In a user study, 31 participating students were asked to rate restaurant recommendations offered in the setting of a context-aware, proactive recommender system. For each of the interaction methods, they saw the same three recommendations. Afterwards, the participants judged the user experience of the methods. The reaction time was measured for each recommendation. The study showed, that the two button card and the swipes methods outperform the action buttons method with regard to reaction time and user experience. The two button card was ranked highest in terms of use quality, the swipes method in terms of design quality. About half of the participants liked each of these two methods best. These findings are especially interesting, as the action buttons method is the interaction pattern included in most Android Wear applications, because it is easier to implement as the other methods.
Perkembangan Filsafat Ilmu serta Kaitannya dengan Teori Hukum

Filsafat ilmu merupakan cabang ilmu fi lsafat yang sangat berguna untuk menjelaskan apa tujuan ilmu bagi manusia. Secara garis besar, fi lsafat ilmu mengemukakan alasan yang mendasar mengapa pengetahuan diperlukan bagi keteraturan dalam hidup manusia. Dalam hubungannya dengan antara fi lsafat ilmu dan teori hukum saling berhubungan erat. Di satu sisi, fi lsafat ilmu adalah bisa digunakan sebagai bahan dasar pembuat teori hukum. Dalam hal ini, teori hukum memang sengaja dirancang untuk lebih bersifat aplikatif dan mampu mmenjawab persoalan keadilan di tengah-tengah masyarakat. Filsafat ilmu bisa menjadi dasar bagi suatu perenungan atau pemikiran secara ketat, secara mendalam tentang pertimbangan nilai-nilai di balik gejala-gejala hukum sebagaimana dapat diamati oleh pancaindera manusia mengenai perbuatan-perbuatan manusia dan kebiasaan-kebiasaan masyarakat. Mengingat objek fi lsafat ilmu adalah pengetahuan, maka masalah atau pertanyaan yang dibahas oleh fi lsafat ilmu itupun antara lain berkaitan dengan manfaat dari pengetahuan itu sendiri. Kata kunci: Hukum, Filsafat, ilmu pengetahuan, manusia