Miracle-dz/UniFAR-FTUs huggingface dataset:
Seasonal Movement Patterns and Long-Range Dispersal of Asian Citrus Psyllid in Florida Citrus

ABSTRACT The Asian citrus psyllid, Diaphorina citri Kuwayama, is the vector of the bacterial pathogen, Candidatus Liberibacter asiaticus, which is the causal agent of huanglongbing (HLB) in the United States. Both short-range and long-range dispersal of D. citri adults affect the spread of HLB; however, little is known about the long-range dispersal capabilities of D. citri in the field or the seasonality of flight behavior. In the present study, an in situ protein marking technique was used to determine the dispersal of D. citri by trapping marked adults under natural field conditions. D. citri movement from abandoned citrus groves to adjacent managed citrus groves was greatest during the spring and summer months and decreased significantly during the colder months (September–March). D. citri were able to traverse potential geographic barriers such as roads and fallow fields. In an experiment conducted to determine long-range dispersal capacity in the absence of severe weather events, D. citri were able to disperse at least 2 km within 12 d. Wind direction was not correlated with the number of marked psyllids captured, indicating substantial flight capability by D. citri. Finally, the number of marked psyllids captured increased with the density of emerging young leaves on surrounding trees. The results confirm that abandoned citrus groves in Florida serve as reservoirs for D. citri, which can disperse across long distances despite geographical barriers.
10-year disease-free survival rates after simultaneous irradiation for prostate cancer with a focus on calculation methodology.

PURPOSE We documented the 10-year disease-free survival rate after simultaneous irradiation for prostate cancer and suggested standards for outcome calculation methodology. MATERIALS AND METHODS From 1992 to 1998, 1,469 consecutive men with clinical stage T1T2NxM0 prostate cancer who did not receive neoadjuvant hormones were treated with simultaneous irradiation, an ultrasound guided transperineal prostate I seed implant followed by external irradiation. Median pretreatment prostate specific antigen (PSA) was 7.1 ng/ml (range 0.3 to 88). All men were treated 5 or more years ago. Median followup was 6 years (range 3 months to 11 years). Disease freedom was defined as the achievement and maintenance of PSA 0.2 ng/ml or less, and treatment failure was defined as a PSA nadir greater than 0.2 ng/ml or a subsequent PSA increase above this level. RESULTS The overall 10-year disease-free survival rate was 83%. Median time to recurrence was 30 months (range 3 months to 8 years) and 24% of recurrences were after 5-year followup. The 10-year outcome according to low, intermediate and high risk group was 93%, 80% and 61%, respectively (p <0.0001). Multivariate analysis of factors related to disease freedom documents that pretreatment PSA, Gleason score and percent positive biopsies were significant but stage and age were not. CONCLUSIONS By calculating outcome with PSA cut point 0.2 ng/ml and evaluation only of men treated 5 or more years ago, the 10-year disease-free survival rates from this study can be reasonably compared with the outcome of radical prostatectomy performed in the PSA era.
Inverse correlation between Helicobacter pylori infection and inflammatory bowel disease.

AIMS: To determine the seroprevalence of Helicobacter pylori in patients with Crohn's disease or ulcerative colitis and in controls without inflammatory bowel disease (IBD). METHODS: One hundred consecutive patients with Crohn's disease, 100 consecutive patients with ulcerative colitis, and 100 age and sex matched controls were studied. Serum H pylori IgG and IgA antibody titres were measured by enzyme immunoassay. RESULTS: The seroprevalence of H pylori was 15% in patients with IBD (13% in patients with Crohn's disease and 18% in patients with ulcerative colitis), whereas the corresponding figure for the controls was 43%. When compared with controls, the seroprevalence of H pylori in patients with IBD was considerably lower in all age groups tested. There was no important difference in treatment with sulphasalazine or in any other medical therapy administered to H pylori positive and negative patients. At the time of blood sampling there was no difference in the level of education or in the employment status between the patients and the controls. CONCLUSIONS: Patients with IBD were less likely to be infected with H pylori than their age and sex matched controls. Neither medical treatment nor socioeconomic factors could explain the difference.
Potential Pitfalls in the Audiological Assessment of Infants and Young Children

Progress made over the last several years in early identification of hearing loss through implementation of newborn hearing screening (NHS) programs has created a unique opportunity for audiologists to provide amplification to children with permanent hearing loss (PHL) very early in life. Along with this long-awaited opportunity comes the daunting responsibility for accurately determining the type, degree and configuration of an infant’s hearing loss so that appropriate counseling of parents, fitting of hearing aids, management planning and follow-up can proceed in a timely manner. Also critically important is to confirm the presence of normal hearing in a baby who failed NHS (a false-positive outcome), so that parental anxieties can be alleviated and unnecessary interventions avoided. Key to this process is the comprehensive audiological assessment. Current otoacoustic, physiological, electrophysiological and behavioral technologies and procedures have provided the pediatric audiologist with an assessment armamentarium that can yield information about the integrity of the auditory pathway from the periphery through the central auditory system. Unfortunately, as clinicians are learning rapidly, there are numerous ‘pitfalls’ that must be anticipated when evaluating the hearing status of infants and very young children and when monitoring children with confirmed PHL over time. Unknowingly encountering an audiological pitfall can deleteriously impact the validity of the audiological assessment, the primary building block of a
Human Metapneumovirus Small Hydrophobic Protein Inhibits NF-κB Transcriptional Activity

ABSTRACT Human metapneumovirus, a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. In this study, we showed that infection of airway epithelial cells or mice with recombinant human metapneumovirus lacking SH expression (rhMPV-ΔSH) enhanced secretion of proinflammatory mediators, including interleukin 6 (IL-6) and IL-8, encoded by two NF-kB-dependent genes, compared to infection with wild-type rhMPV. RhMPV-ΔSH infection resulted in enhanced NF-kB-dependent gene transcription and in increased levels of phosphorylated and acetylated NF-kB without affecting its nuclear translocation, identifying a possible novel mechanism by which paramyxovirus SH proteins modulate NF-kB activation.
Analysis of the relation between intelligence and criminal behavior

Introduction: One of the cognitive aspects of personality is intelligence. A large number of previous studies have shown that the intelligence within the criminal population is decreased, particularly in its verbal aspect.The aim of this study is to determine whether there is a link between intelligence and criminal behavior and how it is manifested.Methods: The research involved criminal inmates of the Correctional institutes of Republic of Srpska and Court Department of Psychiatry Clinic Sokolac who committed homicide and various non-homicide acts. Thetest group consisted of 60 inmates who have committed homicide (homicide offenders) and a control group of 60 inmates who did not commit homicide (non-homicide offenders). The study was controlled, transverse or cross-sectional study.Results: Average intelligence of inmates (homicidal and non-homicidal) was IQ 95.7. Intelligence of homicide inmates was IQ 97.4 and non-homicide IQ 94.09. Intelligence coeffi cients for non-homicide inmatesubgroups were as follows - subgroup consisting of robbery offenders (IQ 96.9), subgroup consisting of theft perpetrators (IQ 93.83), subgroups consisting of other criminal offenders (IQ 92.8). Verbal intellectual ability– IQw of homicide inmates was 91.22, and 91.10 IQw of non-homicide inmates. Intellectual abilities in nonverbal or manipulative part were average, but they were higher in homicide inmates group (IQm 103.65) than in the group of non-homicide inmates (IQm 97.08). Conclusion: Average intelligence of investigated inmates (homicide and non-homicide) is lower than in the general population and corresponds to low average. Verbal part of intelligence is lowered while nonverbalpart is within the average range.
The first major primate extinction: An evaluation of paleoecological dynamics of North American stem primates using a homology free measure of tooth shape.

OBJECTIVES The disappearance of the North American plesiadapoids (stem primates, or plesiadapiforms) in the latest Paleocene has been attributed to competition with rodents over dietary resources. This study compares molar morphology of plesiadapoids and early rodents to assess whether all taxa were adapted to consuming foods of the same structural properties with similar mechanical efficacy. MATERIALS AND METHODS Micro-CT scans of second mandibular molars (M2 s) of plesiadapoids (n = 181) and ischyromyid (early fossil) rodents (n = 13) were evaluated using Dirichlet normal energy (DNE), a dental topographic metric that quantifies the curvature of a tooth's occlusal surface, independent of the orientation of the occlusal plane; this metric can be used to infer diet. RESULTS Comparisons of DNE values for plesiadapoids and rodents show that rodents shared functionally similar dental morphology with at least some plesiadapid plesiadapoids and thus were likely adapted to processing foods with similar physical properties. However, the DNE values for rodents contrast markedly with those for the other two plesiadapoid families, the Carpolestidae and Saxonellidae. CONCLUSIONS It is unlikely that direct competition over food resources with rodents played a major role in the extinction of carpolestids and saxonellids, as members of these families were capable of consuming a range of foods that were not accessible to rodents. Although several plesiadapid species overlap with rodents in their range of DNE values, only three overlap in time. One of these (Plesiadapis cookei) may have been too large to be in direct competition with rodents, another (Plesiadapis dubius) has DNE values substantially different (higher) than those of rodents, whereas the third, Chiromyoides, has teeth of both a similar size and DNE value to those of Clarkforkian rodents. If dietary niche overlap with rodents played a direct role in the decline of plesiadapiforms, it can only have potentially done so for Chiromyoides.
Monitoring of the neuromuscular transmission by electromyography (I). Stability and temperature dependence of evoked EMG response compared to mechanical twitch recordings in the cat

The stability over time and the effect of muscle temperature change were evaluated for the evoked compound EMG and for the mechanomyogram of the tibialis anterior muscle of 7 anaesthetized cats. Both EMG areas and amplitudes were recorded. During stimulation for 3 h with 0.1 Hz (one leg) and train‐of‐four (TOF) (the other leg), the EMG was stable while the mechanomyogram initially increased 35–50% in the first 7–8 min and then decreased 19–22% and 5–8% over the first and second 1.5‐h period, respectively. During subsequent mean muscle temperature reduction to 28.8°C (0.1 Hz) and 29.7°C (TOF) and rewarming, an inverse linear relationship was found between temperature and both the EMG and the mechanomyogram. During temperature reduction EMG increased about 6% (areas) and 2% (amplitudes) per °C. During rewarming, parameters decreased about 4.5% and 2% per °C, respectively (P<0.05 comparing EMG areas during cooling and rewarming). TOF ratio of the EMG was not affected by temperature. A very large interindividual variation was observed for the effect of temperature on the mechanomyogram with changes ranging up to 15% per °C for some cats. TOF ratio of the mechanomyogram was reduced from 1.02 to0.94 at lowest muscle temperature. It is concluded that the evoked EMG may be preferable to the mechanomyogram in cat experiments investigating the neuromuscular transmission.
THE CALIBRATION OF MONOCHROMATIC FAR-INFRARED STAR FORMATION RATE INDICATORS

Spitzer data at 24, 70, and 160 μm and ground-based Hα images are analyzed for a sample of 189 nearby star-forming and starburst galaxies to investigate whether reliable star formation rate (SFR) indicators can be defined using the monochromatic infrared dust emission centered at 70 and 160 μm. We compare recently published recipes for SFR measures using combinations of the 24 μm and observed Hα luminosities with those using 24 μm luminosity alone. From these comparisons, we derive a reference SFR indicator for use in our analysis. Linear correlations between SFR and the 70 μm and 160 μm luminosity are found for L(70) ≳ 1.4 × 1042 erg s−1 and L(160) ≳ 2 × 1042 erg s−1, corresponding to SFR ≳ 0.1–0.3 M☉ yr−1, and calibrations of SFRs based on L(70) and L(160) are proposed. Below those two luminosity limits, the relation between SFR and 70 μm (160 μm) luminosity is nonlinear and SFR calibrations become problematic. A more important limitation is the dispersion of the data around the mean trend, which increases for increasing wavelength. The scatter of the 70 μm (160 μm) data around the mean is about 25% (factor ∼2) larger than the scatter of the 24 μm data. We interpret this increasing dispersion as an effect of the increasing contribution to the infrared emission of dust heated by stellar populations not associated with the current star formation. Thus, the 70 (160) μm luminosity can be reliably used to trace SFRs in large galaxy samples, but will be of limited utility for individual objects, with the exception of infrared-dominated galaxies. The nonlinear relation between SFR and the 70 and 160 μm emission at faint galaxy luminosities suggests a variety of mechanisms affecting the infrared emission for decreasing luminosity, such as increasing transparency of the interstellar medium, decreasing effective dust temperature, and decreasing filling factor of star-forming regions across the galaxy. In all cases, the calibrations hold for galaxies with oxygen abundance higher than roughly 12 +log(O/H) ∼ 8.1. At lower metallicity, the infrared luminosity no longer reliably traces the SFR because galaxies are less dusty and more transparent.
Canalicular Laceration: An 11‐Year Epidemiologic and Clinical Study

From 1977 through 1987, a total of 222 patients (166 male and 56 female patients) underwent surgical repair of canalicular laceration at Wills Eye Hospital. Demographic and clinical information were collected from the medical records and by written questionnaire or telephone interview. Most injuries occurred in children or young adults (median age, 20 years). Overall, blows from fists was the most common cause of injury (52 patients, 23.4%). Dog bites or scratches were the most frequent causes among children. A total of 147 injuries (66.2%) involved the lower eyelid, 61 (27.5%) the upper eyelid, and 14 (6.3%) the upper and lower eyelids on the same side. Constant or stress epiphora occurred postopera-tively significantly more often among patients with combined upper and lower canalicular injuries (61.5%) than among those with single canalicular laceration (19.7%) (p < 0.01). Analysis with logistic regression showed epiphora to be more common among adults than children (p < 0.05) when the pigtail probe had been used intraop-eratively (p < 0.05), or when no canalicular stent had been placed at the time of surgical repair (p < 0.05). No statistically significant associations were found between sex, cause of injury, type of canalicular stent, or time interval from injury to surgical repair and presence of postoperative epiphora.
Hyperexcitability of intact neurons underlies acute development of trauma‐related electrographic seizures in cats in vivo

Cortical trauma can lead to development of electrographic paroxysmal activities. Current views of trauma‐induced epileptogenesis suggest that chronic neuronal hyperexcitability and extensive morphological reorganization of the traumatized cortex are required for the generation of electrographic seizures. However, the mechanisms responsible for the initiation of electrographic seizures shortly after cortical injury are poorly understood. Here we show that, in the experimental model of partially deafferented (undercut) cortex, an increase in intrinsic and synaptic excitability of neurons in areas adjacent to the undercut cortex is sufficient for the generation of electrographic paroxysmal activity within few hours after partial cortical deafferentation. Locally increased and spatially restricted neuronal excitability arose from the increased incidence of intrinsically bursting neurons, enhanced intrinsic and synaptic neuronal responsiveness, and slight disinhibition. These mechanisms only operate in neurons located in the vicinity of partially deafferented sites because, after the cortical injury, partially deafferented neurons are mostly silent and hypoexcitable. Our results suggest that trauma‐induced electrographic seizures first arise in cortical fields that are closest to the site of injury and such seizures do not require long‐term neuronal reorganization.
Maternal serum leptin concentration during the second trimester of pregnancy: association with fetal chromosomal abnormalities

Recent studies suggest that leptin, the product of the obese gene, is produced by the placenta during pregnancy. The present study addressed the question whether second trimester maternal serum leptin could be altered by fetal Down syndrome or Edwards syndrome. Maternal serum leptin concentrations were measured in 18 pregnancies complicated with Down syndrome, six pregnancies complicated with Edwards syndrome and 183 uncomplicated pregnancies during the second trimester of pregnancy. The present results demonstrate that leptin concentrations in uncomplicated pregnancies slightly decrease from the 16th week of pregnancy, reaching a minimum of 18.8 ng/ml around the 20th week, and then rapidly increase to 28.2 ng/ml by the 24th week. Leptin correlation with maternal body weight decreases from r=0.695 at 16–17 week of gestation to r=0.544 at >22 weeks of gestation. There was no significant difference between the mean MoMs of Down syndrome‐ (0.926) or Edwards syndrome‐ (0.960) affected pregnancies and normal pregnancies (1.002). A weak correlation (r=0.18, p<0.02) was observed between corrected leptin MoMs and human chorionic gonadotrophin (hCG) MoMs in normal pregnancies. It is assumed that around the 20th week of pregnancy placental leptin production is activated or at least is accelerated and it is added to the amount of leptin produced by maternal adipose tissue. Fetal Down syndrome or Edwards syndrome does not seem to alter maternal leptin concentration and therefore leptin cannot be used as a marker for these chromosomal abnormalities in the early second trimester of pregnancy. Copyright © 2002 John Wiley & Sons, Ltd.
Reduction of postoperative adhesions by N,O-carboxymethylchitosan and spermine NONOate in rats.

BACKGROUND Postsurgical adhesions can occur following virtually all types of surgery, resulting in serious clinical complications. Therefore, prevention of adhesions is an important goal of surgical practice. A rat uterine horn model was used to investigate the efficacy of N,O-carboxymethylchitosan (NOCC) and spermine NONOate (SPER/NO) alone and in combination in preventing adhesion formation. METHODS Sixty Wistar albino rats underwent bilateral uterine horn injury with a unipolar cautery. Study groups were as follows: (i) control group, no adjuvant therapy; and those with adjuvant applied, (ii) normal saline group, 2 ml of normal saline was given; (iii) NOCC group, 2 ml of 2% NOCC gel was given; (iv) SPER/NO group, 2 ml of SPER/NO (0.5 mg/ml) was given, and (v) NOCC plus SPER/NO group, 2 ml of 2% NOCC gel including SPER/NO (0.5 mg/ml) was given. After 14 days, all animals were euthanatized, and a standard adhesion scoring system including extent and severity scores was applied by a blinded examiner. RESULTS The extent score in NOCC plus SPER/NO group was significantly lower than those of control and normal saline groups (p < 0.05). The extent score in NOCC group was significantly lower than that of normal saline group (p < 0.05). The extent score in NOCC plus SPER/NO group was significantly lower than that of SPER/NO group (p < 0.05). The severity score was significantly lower in NOCC plus SPER/NO and NOCC groups than that of control group (p < 0.05). The severity score was significantly lower in NOCC plus SPER/NO group than that of SPER/NO group (p < 0.05). CONCLUSIONS Postoperative administration of NOCC gel and SPER/NO alone and especially in combination to the site of peritoneal injury reduces the formation of adhesions in the rat uterine horn model.
Targeting Noncognitive Skills to Improve Cognitive Outcomes: Evidence from a Remedial Education Intervention

We study an education intervention targeting underachieving pupils’ noncognitive skills with the aim of improving attendance and cognitive outcomes. We evaluate the policy effect on test scores in national exams at age 16 exploiting repeated observations to control for unobservables. We find little evidence of improved cognitive outcomes. We further examine the policy impact on students’ absences. Lacking repeated observations on this outcome, we simulate the effect of unobservables on attendance. While the intervention had beneficial effects on school presence, these did not translate to improved cognitive outcomes. Conversely, the policy generated positive spillover effects on nontreated students’ test scores.
Metabolism of 3-methylindole by a methanogenic consortium

A methanogenic 3-methylindole (3-MI)-degrading consortium, enriched from wetland soil, completely mineralized 3-MI. Degradation proceeded through an initial hydroxylation reaction forming 3-methyloxindole. The consortium was unable to degrade oxindole or isatin, suggesting a new pathway for 3-MI fermentation.
Measuring Alpha in the Fund Management Industry: Do Female Managers Perform Better?

This paper examines the performance of 358 European diversified equity mutual funds controlling for gender differences. Fund performance is evaluated against funds’ designated market indices and representative style portfolios. Consistently with previous studies, no significant differences in performance and risk are found between female and male managed funds. However, perverse market timing manifests itself mainly in female managed funds and in the left tail of the returns distribution. Interestingly, at fund level there is evidence of significant overperformance that survives even after accounting for funds’ exposure to known risk factors. Employing a quantile regression approach reveals that fund performance is highly dependent on the selection of the specific quantile of the returns distribution; also, style consistency for male and female managers manifests itself across different quantiles. These results have important implications for fund management companies and for retail investors’ asset allocation strategies.