Miracle-dz/UniFAR-FTUs huggingface dataset:
Limited Dictionary Builder: An approach to select representative tokens for malicious URLs detection

Cybercriminals use Malicious Uniform Resource Locators (URLs) as the entry to implement a variety of web attacks, such as phishing, spamming, and malware distribution, which may lead to huge finance and data loss. Thus, malicious URLs should be detected as accurately and quickly as possible. Heuristic-based detection approaches are one of the most popular methods to achieve the above goals. The detection results come from the usage of many heuristic features in this approach. However, tremendous new pages and meaningless tokens lead to the explosion of feature sets, and exhaust memory space finally. In this paper, we try to address the problem by selecting some representative members from the initial feature set, which should have the best predictive ability among the same number of selected features. For each feature, we give an evaluation method of O(1) complexity to measure its predictive ability. Then we make the selection based on all the measured values with linear complexity. Experimental results show that our approach can achieve almost the same false negative rate using only 8.3% features for malicious URLs detection, comparing with prior approaches. Moreover, our approach may work efficiently in the big data era, as it can handle 20 thousand URLs per second in our experiments on average.
PlasmoGF: an integrated system for comparative genomics and phylogenetic analysis of Plasmodium gene families

UNLABELLED Malaria, one of the world's most common diseases, is caused by the intracellular protozoan parasite known as Plasmodium. Recently, with the arrival of several malaria parasite genomes, we established an integrated system named PlasmoGF for comparative genomics and phylogenetic analysis of Plasmodium gene families. Gene families were clustered using the Markov Cluster algorithm implemented in TribeMCL program and could be searched using keywords, gene-family information, domain composition, Gene Ontology and BLAST. Moreover, a number of useful bioinformatics tools were implemented to facilitate the analysis of these putative Plasmodium gene families, including gene retrieval, annotation, sequence alignment, phylogeny construction and visualization. In the current version, PlasmoGF contained 8980 sets of gene families derived from six malaria parasite genomes: Plasmodium. falciparum, P. berghei, P. knowlesi, P. chabaudi, P. vivax and P. yoelii. The availability of such a highly integrated system would be of great interest for the community of researchers working on malaria parasite phylogenomics. AVAILABILITY PlasmoGF is freely available at http://bioinformatics.zj. cn/pgf/
Sickness Benefit Rules and Work Absence: An Empirical Study Based on European Data

Using data from the 2010 European Working Conditions Survey, this study explores the determinants of health-related absences from work in European countries. The focus is on the impact of sick leave rules. Five parameters of the sickness benefit system are taken into account: the requirement to produce a doctor’s certificate on the first day of absence, the length of the qualifying period, the existence of a waiting period before receipt of benefits, the compensation level, and the duration of benefits. Employees’ absence behaviors are analyzed using multilevel logistic regressions. The results show that cross-country differences in the probability of absence are partly attributable to differences in sick leave legislation. The most significant factor is whether employers are required to continue paying full wages in case of illness. As expected, the propensity to be absent is significantly higher in countries where this rule applies.
Federal Work-Study: Past Its Prime, or Ripe for Renewal?

Federal Work-Study (FWS) is on the chopping block: the Trump administration’s recently-released budget summary seeks to cut program funding by nearly 50 percent, from $990 million to $500 million, and to “reform the program to ensure funds go to undergraduate students who would benefit most. ”1 Many observers have expressed surprise that the administration would take aim at the program—which seems well-aligned with conservative ideals around personal responsibility and work-based learning—even as President Trump takes executive action to support and expand apprenticeships.2
Coherent Detection-Based Automatic Bias Control of Mach–Zehnder Modulators for Various Modulation Formats

In this paper, a method to automatically control the bias voltages of LiNbO3 Mach-Zehnder modulator (MZM) is proposed and demonstrated experimentally. The automatic bias control (ABC) method is based on low cost coherent detection employing 3 × 3 optical coupler, which enhances the dither detection sensitivity. By minimizing the monitored dither frequency components which represents the residual carrier component in the optical signal, the modulator biases are optimized. A 0-π/2 square-wave phase modulation is introduced to mitigate the detection fluctuation induced by the imbalance of 3 × 3 coupler and improve the monitoring accuracy. Experiments show that the proposed method is universal for different modulation formats. High bias control precision is achieved for inner in-phase/quadrature (I/Q) branches and outer phase bias of optical quadrature modulator. The penalty caused by the proposed ABC is negligible for both single carrier (SC) modulation and optical orthogonal frequency division multiplexing modulation. The tolerance to temperature disturbance is also demonstrated.
CD154+ Graft Antigen‐Specific CD4+ T Cells are Sufficient for Chronic Rejection of Minor Antigen Incompatible Heart Grafts

We used a defined model system to address the role of minor histocompatibility antigen‐specific CD4+ T cells in chronic rejection. The coronary arteries of vascularized heart grafts expressing the model antigen ovalbumin developed intimal hyperplasia in normal recipients and those lacking CD8+ T cells but not in those lacking CD4+ T cells. Furthermore, purified ovalbumin‐specific CD4+ T cells from T‐cell antigen receptor transgenic mice caused intimal hyperplasia in ovalbumin‐expressing heart grafts in lymphocyte‐deficient mice. The graft antigen‐specific CD4+ T cells only caused intimal hyperplasia when expressing CD154 and were found in the intima of the affected coronary arteries along with CD40+ cells, CD11c+ dendritic cells and CD11b+, Gr‐1+ monocytes. These results show that minor histocompatibility antigen‐specific CD4+ T cells are required to cause the classical vascular changes of chronic rejection. They are capable of doing so without contributions from other lymphocytes, and may cause intimal hyperplasia by using CD154 to stimulate other non‐lymphoid cells in the intima.
The LIM‐domain protein Zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo

The question of how subdivision of embryo into cell territories acquiring different fates is coordinated with morphogenetic movements shaping the embryonic body still remains poorly resolved. In the present report, we demonstrate that a key regulator of anterior neural plate patterning, the homeodomain transcriptional repressor Xanf1/Hesx1, can bind to the LIM‐domain protein Zyxin, which is known to regulate cell morphogenetic movements via influence on actin cytoskeleton dynamics. Using a set of deletion mutants, we found that the Engrailed‐type repressor domain of Xanf1 and LIM2‐domain of Zyxin are primarily responsible for interaction of these proteins. We also demonstrate that Zyxin overexpression in Xenopus embryos elicits effects similar to those observed in embryos with downregulated Xanf1. In contrast, when the repressor‐fused variant of Zyxin is expressed, the forebrain enlargements typical for embryos overexpressing Xanf1 develop. These results are consistent with a possible role of Zyxin as a negative modulator of Xanf1 transcriptional repressing activity. Developmental Dynamics 237:736–749, 2008. © 2008 Wiley‐Liss, Inc.
Fission and fusion of Darwin's finches populations

This study addresses the causes and evolutionary consequences of introgressive hybridization in the sympatric species of Darwin's ground finches (Geospiza) on the small island of Daphne Major in the Galápagos archipelago. Hybridization occurs rarely (less than 2% of breeding pairs) but persistently across years, usually as a result of imprinting on the song of another species. Hybrids survive well under some ecological conditions, but not others. Hybrids mate according to song type. The resulting introgression increases phenotypic and genetic variation in the backcrossed populations. Effects of introgression on beak shape are determined by the underlying developmental genetic pathways. Introgressive hybridization has been widespread throughout the archipelago in the recent past, and may have been a persistent feature throughout the early history of the radiation, episodically affecting both the speed and direction of evolution. We discuss how fission through selection and fusion through introgression in contemporary Darwin's finch populations may be a reflection of processes occurring in other young radiations. We propose that introgression has the largest effect on the evolution of interbreeding species after they have diverged in morphology, but before the point is reached when genetic incompatibilities incur a severe fitness cost.
The effect of irbesartan in reducing cardiovascular risk in hypertensive type 2 diabetic patients: an observational study in 16 600 patients in primary care

SUMMARY Objectives: As arterial hypertension substantially increases the risk of premature death, cardiovascular disease and renal insufficiency in patients with type 2 diabetes, effective and safe antihypertensive therapy is of importance. Therefore, the effect of irbesartan as monotherapy, or in fixed combination with hydrochlorothiazide, on blood pressure, metabolic parameters and microalbuminuria and the safety and tolerability of the drug were assessed. Research design and methods: Multicentric, prospective, open phase IV study over 3 months in 16 600 patients with the clinical diagnoses of hypertension and type 2 diabetes. Blood pressure was measured sphygmometrically and albuminuria was assessed with semi-quantitative urine dipsticks. Main outcome measures: Systolic (SBP) and diastolic (DBP) blood pressure reduction, proportion of patients with microalbuminuria and cardiovascular risk calculated based on the SCORE score, each after a follow-up of 3 months compared to baseline. Number and nature of adverse events (AEs). Results: The sample consisted of 51.3% men, mean age was 62.2 ± 10.7 years, 53.9% of patients were overweight and 26.4% were obese. Mean SBP/DBP decrease after 3 months was 22.3/11.2 mmHg. The BP lowering effect was similar in the analyses of various subgroups (according to age group, sex, presence of micro- or macrovascular complications). Irbesartan treatment reduced the percentage of patients with microalbuminuria from 45.6% to 30.6% at 3 months (32.9% relative reduction). Metabolic parameters (lipids, blood glucose, HbA1c) and weight were improved significantly or showed trends for improvement, respectively. The mean 10-year cardiovascular risk as calculated with the SCORE score was decreased from a baseline value of 9.8% to 5.7% (–58% relative reduction). Tolerability was excellent: only 0.3% experienced an AE. Conclusions: Treatment with irbesartan in patients with concomitant hypertension and type 2 diabetes led to large blood pressure reductions. In view of the renoprotective effect documented by the reduced rate of patients with albuminuria, and the improvement of further metabolic parameters, these changes translate into a reduction of cardiovascular risk.
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase from Methanobacterium thermoautotrophicum. Studies of the catalytic mechanism of H2 formation using hydrogen isotopes.

H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase is a novel hydrogenase found in most methanogenic archaea. It catalyzes the reversible conversion of N5,N10-methylenetetrahydromethanopterin (CH2 = H4MPT) to N5,N10-methenyltetrahydromethanopterin (CH identical to H4MPT+) and dihydrogen; CH2 = H4MPT + H+<-->CH identical to H4MPT(+) + H2; delta G degrees ' = + 5 kJ/mol. In the following investigation, the formation of H2, HD and D2 was studied in experiments in which either the methylene group of CH2 = H4MPT or water were deuterium labelled. In the case of CD2 = H4MPT and H2O, the dihydrogen formed immediately after the start of the reaction was composed of approximately 50% HD and 50% of H2 at all pH tested. In the case of CH2 = H4MPT and D2O, the dihydrogen generated was composed of approximately 50% HD and 50% D2 at pD 5.7 and of approximately 85% HD and 15% D2 at pD 7.0. Evidence is presented that the enzyme catalyzes a CH identical to H4MPT(+)-dependent isotopic exchange between HD and H2O and between HD and D2O, yielding H2 and D2, respectively. A catalytic mechanism aimed to explain these findings is discussed.
Combined Electric and Acoustic Stimulation With Hearing Preservation: Effect of Cochlear Implant Low-Frequency Cutoff on Speech Understanding and Perceived Listening Difficulty

Objective: The primary objective of this study was to assess the effect of electric and acoustic overlap for speech understanding in typical listening conditions using semidiffuse noise. Design: This study used a within-subjects, repeated measures design including 11 experienced adult implant recipients (13 ears) with functional residual hearing in the implanted and nonimplanted ear. The aided acoustic bandwidth was fixed and the low-frequency cutoff for the cochlear implant (CI) was varied systematically. Assessments were completed in the R-SPACE sound-simulation system which includes a semidiffuse restaurant noise originating from eight loudspeakers placed circumferentially about the subject’s head. AzBio sentences were presented at 67 dBA with signal to noise ratio varying between +10 and 0 dB determined individually to yield approximately 50 to 60% correct for the CI-alone condition with full CI bandwidth. Listening conditions for all subjects included CI alone, bimodal (CI + contralateral hearing aid), and bilateral-aided electric and acoustic stimulation (EAS; CI + bilateral hearing aid). Low-frequency cutoffs both below and above the original “clinical software recommendation” frequency were tested for all patients, in all conditions. Subjects estimated listening difficulty for all conditions using listener ratings based on a visual analog scale. Results: Three primary findings were that (1) there was statistically significant benefit of preserved acoustic hearing in the implanted ear for most overlap conditions, (2) the default clinical software recommendation rarely yielded the highest level of speech recognition (1 of 13 ears), and (3) greater EAS overlap than that provided by the clinical recommendation yielded significant improvements in speech understanding. Conclusions: For standard-electrode CI recipients with preserved hearing, spectral overlap of acoustic and electric stimuli yielded significantly better speech understanding and less listening effort in a laboratory-based, restaurant-noise simulation. In conclusion, EAS patients may derive more benefit from greater acoustic and electric overlap than given in current software fitting recommendations, which are based solely on audiometric threshold. These data have larger scientific implications, as previous studies may not have assessed outcomes with optimized EAS parameters, thereby underestimating the benefit afforded by hearing preservation.
Phenotypic variability in friedreich ataxia: Role of the associated GAA triplet repeat expansion

We studied genotype‐phenotype correlations in a group of 100 patients with typical Friedreich ataxia (FRDA), and in three groups of patients with atypical clinical presentations, including 44 Acadian FRDA, 8 late‐onset FRDA (LOFA), and 6 FRDA with retained reflexes (FARR). All patients, except 3 with typical FRDA, carried two copies of the FRDA‐associated GAA triplet repeat expansion. Overall, the phenotypic spectrum of FRDA appeared to be wider than defined by the currently used diagnostic criteria. Our study indicated the existence of several sources of variability in FRDA. Patients with larger GAA expansions tended to have earlier onset and were more likely to show additional manifestations of the disease. Mitotic instability of the expanded GAA repeats may partially account for the limited degree of correlation between expansion sizes as determined in lymphocytes and clinical parameters. Some clinical variants associated with specific FRDA haplotypes, such as Acadian FRDA and FARR, turned out to be unrelated to expansion sizes. No polymorphism in the frataxin coding sequence could be associated with these clinical variants.
Evaluation of mandibular transverse widths in patients affected by unilateral and bilateral cleft lip and palate using cone beam computed tomography.

OBJECTIVE To evaluate the mandibular dental, alveolar, and skeletal transversal widths in patients affected by unilateral (UCLP) and bilateral (BCLP) cleft lip and palate and to compare the findings with a well-matched normal occlusion sample using cone beam computed tomography images. MATERIALS AND METHODS The study sample consisted of 75 patients divided into three groups: the UCLP (29 patients; mean age: 15.40 ± 3.22 years), BCLP (18 patients; mean age: 15.54 ± 3.72 years), and normal occlusion (28 patients; mean age: 15.82 ± 2.11 years) groups. Mandibular dental (intercanine and -molar), alveolar (intercanine and -molar), and skeletal (bigonial width) transversal measurements were performed three-dimensionally and analyzed using the one-way variance analysis and post hoc Tukey tests. RESULTS Patients affected by UCLP and BCLP had statistically significantly lower intercanine alveolar widths (P < .05 and P < .001, respectively) and larger intermolar (P < .001 and P < .05, respectively) and intermolar alveolar widths (P < .001) compared with the normal occlusion group. Furthermore, the patients affected by UCLP and BCLP had similar mandibular dental, alveolar, and skeletal transversal widths (P > .05). CONCLUSION The UCLP and BCLP groups showed statistically significantly smaller values for intercanine alveolar widths and larger values for intermolar dental and alveolar widths compared with the normal occlusion group. This shows the importance of using individualized archwires according to the pretreatment arch widths of the patients affected by UCLP and/or BCLP.
The effect of education on backpack wearing and posture in a middle school population.

PURPOSE The effect of education on proper wearing of a backpack was studied to determine whether or not a middle school population would improve posture during load carriage by maintaining a more natural posture and to determine if schoolchildren would comply with proper backpack wearing. METHOD 17 middle school children with a mean age of 12.7 years were randomized into control and intervention groups. Participants were videotaped in four conditions from an anterior view and from a lateral view. Members of both groups participated in Sessions A and C, which consisted of videotaping of the four conditions. Intervention members additionally participated in Session B, consisting of education on how to wear a backpack properly. All participants were interviewed concerning their participation and its effect on how they wore their backpack. Video footage was analyzed to calculate the change in skeletal angles as a result of different methods of load carriage. Interview data was coded and analyzed. RESULTS No quantitative significance was found between control and intervention groups in regards to education on proper backpack wearing improving posture. Interviews revealed that intervention group members benefited from the education on proper wearing of a backpack. 87.5% of the intervention group members proceeded to continue wearing the backpack properly after the education intervention. CONCLUSIONS Education regarding proper wearing of a backpack may impact the middle school aged child by improving quality of life as noted through decrease in reports of musculoskeletal pain by participants.
Designing a Data Visualization Dashboard for Managing the Sustainability Communication of Healthcare Organizations on Facebook

Healthcare organizations are being increasingly requested to publicize their sustainability efforts on digital environments and social media, in part because previously passive patients are now becoming active customers. This paper investigates how leading healthcare organizations are using Facebook to communicate their sustainability, in terms of their focus on different components of the 3Ps (people, profit, planet) and interactive communication strategies used on social media. A content analysis was made of the Facebook posts (n = 6145) of healthcare organizations in the Forbes Global 2000 (2017 annual ranking) from 2015 to mid-2018. Our findings show that the social component of sustainability prevails over environmental and economic issues, although it does not seem to generate increased consumer engagement (in terms of users’ likes, comments, reactions, etc.). A data visualization dashboard was developed to help managers in benchmarking competitors and assessing how they can increase response rates and public engagement on social media, thus encouraging the active participation of users. The study also provides useful insights for communication managers in identifying how to use deliberative tools to develop consumer relationships on social media and aligning companies and consumers regarding shared sustainability themes.
Characterization and Distribution of a New Cell Surface Marker of Neuronal Precursors

In a screen for novel cell surface markers of neuronal progenitors, we recently identified mAb 2F7 that recognizes an epitope present on both progenitor cells and postmitotic neurons, in the developing CNS and PNS. In the embryonic rat telencephalon, the mAb 2F7 epitope is expressed by migratory and postmigratory neurons in the developing cerebral cortex, as well as by presumptive neuronal progenitor cells of the ventricular zone. In the neonatal forebrain mAb 2F7 labels postmitotic neurons, including those of the developing cerebral cortex and olfactory bulb, as well as the axons of the corpus callosum. While mAb 2F7 immunoreactivity is present on only a low density of the neuronal progenitor cells situated in the anterior part of the subventricular zone, a progressively higher proportion of cells forming the rostral migratory stream express this epitope. mAb 2F7 labels the surfaces of neurons and neuronal precursors, but not mature oligodendrocytes and astrocytes in primary cultures derived from the rat neural tube. In vivo, migrating neural crest cells, motor neurons, and axonal projections associated with the spinal cord express the mAb 2F7 epitope. Immunoblot analyses reveal that the mAb 2F7 epitope resides on several high-molecular-weight, membrane-associated proteins, and is likely to be composed of N-linked carbohydrate. These findings suggest that mAb 2F7 recognizes a novel epitope that is present on progenitor cells and postmitotic, differentiating neurons in the developing mammalian nervous system.