Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Diode Laser Therapy as an Adjunct to Scaling and Root Planing in the Treatment of Aggressive Periodontitis: A 1-Year Randomized Controlled Clinical Trial.

OBJECTIVE The aim of this study was to investigate and compare the clinical, microbial, and inflammatory effects of a diode laser as an adjunct to scaling and root planing (SRP) versus SRP alone for the treatment of generalized aggressive periodontitis (GAgP). METHODS Using a split-mouth design, 31 patients with GAgP were enrolled in the study. The maxillary right and left quadrants were randomly assigned to SRP+diode laser or SRP alone. Patients were examined on a regular basis for clinical, microbiological, and inflammatory mediator changes over a 1-year period. Clinical attachment level (CAL) was the primary outcome variable chosen. In addition, subgingival biofilm samples and gingival crevicular fluid (GCF) inflammatory mediators were analyzed at each follow-up session. RESULTS Compared to baseline, both treatments demonstrated an improvement in periodontal parameters at 1 year. However, SRP+diode laser produced a significant improvement in probing depth (PD; 2.56 ± 0.44 vs. 3.36 ± 0.51 mm, p < 0.05) and CAL (3.47 ± 0.25 vs. 4.11 ± 0.26 mm, p < 0.05) values compared to SRP alone. Similarly, in the SRP+diode laser group, the bacteria of orange complex group were significantly reduced at 30 and 60 days compared to SRP alone. Moreover, SRP+diode laser determined a reduction in mean GCF level of interleukin (IL)-1β and IL-1β/IL-10 ratio at 15 and 30 days compared to SRP alone (p < 0.05). CONCLUSIONS At 1 year, SRP+diode laser yielded a significant reduction in some clinical parameters, while microbial and inflammatory mediator changes were not significantly reduced compared to SRP alone.
Mothers' Participation in the Hospitalized Children's Care and their Satisfaction

Background: Support given to children by their families is the most significant factor that determines children’s reactions against health problem and nursing care. Family centered care, is a practice that increases the quality of the services and affects the parents’ satisfacti on positively. Aims and objective: This study was conducted to the relationship betw e n parent satisfaction and family centered care perception, parent participation and demographic characters. Desing: This is a descriptive study. Method: The participants in this study were 285 parents. D ata were collected using the Family Descriptive Questionnaire Form, Pediatric Quality of Life Inven tory Health Care Satisfaction Scale, and Family-Cen tered Care Scale. Data were analyzed using descriptive s atistics, independent t-test, one-way ANOVA, Pears on correlation analysis. Result: The mean age of the mothers was found as 28.49 ±5. 84 years. Pediatric Quality of Life Inventory Health Care Satisfaction Scale and Family-Centered Care Scale scores were found to increase at signif ica t levels in the cases that the mothers were informed about the health care activities for their childre n, they were shown how to do these activities, and they were giv n feedback (p=0.000). A strong positive relationship (r s= 0.730**) was obtained between the mothers’ Pediatri c Quality of Life Inventory Health Care Satisfactio n Scale and Family-Centered Care Scale scores (p<0.001). Conclusion: There is a positive relationship between parent’s h ealt care satisfaction and family centered care. So, the nurses should do their best to involve the par nt in care of their children in accordance fami ly centered care principles.
Early changes in peritumorous oedema and contralateral white matter after dexamethasone: a study using proton magnetic resonance spectroscopy.

AIMS: To study the mechanism of action of steroids in patients with peritumorous oedema. METHODS: To investigate early cerebral metabolic changes proton magnetic resonance spectroscopy (1H-MRS) was used before and 11 to 14 hours after treatment with dexamethasone (12 mg oral loading and 4 mg four times daily maintenance). Nine patients (two men, seven women, mean age 54) with pronounced oedema associated with various intracranial tumours (two astrocytomas, three meningiomas, two glioblastoma, and two metastases) were examined using MRI and MRS. SE1500/135 volume selected MRS (mean volume 21 ml) were performed on an oedematous region and a contralateral region. All spectra were acquired with and without water suppression. Metabolite peak area ratios were determined. RESULTS: Regions of oedema had significantly (P < 0.01) higher unsuppressed water than the contralateral regions, as expected. There was no change at this early time point after dexamethasone. The ratio of the area of choline containing compounds to that creatine and phosphocreatine compounds was determined after which the serial ratios of these before and after were calculated (a serial ratio of 1.0 would indicate no change in the choline to creatine ratios after steroid administration). The mean serial ratios for the area of oedema were 1.02 (SEM 0.08) and 1.10 (0.08) for the contralateral volume of interest, indicating no significant changes. However, significant changes (P < 0.02) were found in the N-acetyl-aspartate (NAA)/choline serial ratios (0.86 (0.06) in the area of oedema, 1.20 (0.10) in contralateral brain) and the NAA/creatine serial ratios (0.86 (0.08) for the oedema, 1.25 (0.11) in contralateral brain). CONCLUSIONS: Such rapid changes may be explained either by relatively large alterations in the relaxation characteristics of NAA or, more controversially, by actual changes in the amounts of NAA. It is proposed that steroids act primarily by causing early metabolic changes that are later expressed in improvements in intracranial volume relations.
Human Papillomavirus infections in Cuban women with cervical intraepithelial neoplasia.

The aims of the current study were to detect different HPV types in Cuban patients with different grades of cervical intraepithelial neoplasia (CIN) and to assess the association between HPV infection and other risk factors involved in the development of cervical cancer in Cuban women. We analyzed 60 samples from women with a previous diagnosis of abnormal cytology (15 CIN-1 36 CIN-2 and 9 CIN-3) who were referred to the Gynecology and Obstetrics Department at Eusebio Hernandez Maternity Hospital in Havana Cuba by their primary clinics. Epidemiologic data were obtained from standardized questionnaires. The questionnaire was designed to provide information on sexual and reproductive behavior (reproductive and gynecological history sexual history and the age of the first intercourse) socioeconomic conditions cigarette smoking and oral contraceptive use. During the first visit to the hospital an informed consent was obtained from each patient. For HPV detection ectocervical and endocervical scrapings were used; Pap smears were also analyzed. Every patient underwent colposcopic examination which included two schematic drawings of the reactions of the acetic acid and Lugol solution. This method allowed the detection of leucoplastic lesions atypical transformation zones cervicitis colpitis and condylomatous lesions. (excerpt)
Presymptomatic motor neuron loss and reactive astrocytosis in the SOD1 mouse model of amyotrophic lateral sclerosis

In familial amyotrophic lateral sclerosis (fALS), there is a need to establish more precisely the progression of the disease, particularly whether there is gradual presymptomatic neuronal loss or an abrupt loss coinciding with the symptomatic stage. To elucidate this, we investigated the progression of motor neuron loss through morphological techniques, reactive astrocytosis, and expression of ubiquitin and neurofilament proteins, by immunohistochemistry, in SOD1 G93A mice with a protracted disease course and control mice. Loss of motor neurons in SOD1 G93A mice followed a biphasic progression, with an initial loss at 126 days of age, followed by a gradual loss from onset of symptoms through to end‐stage disease. Reactive astrocytosis was first observed at 70 days of age and showed a gradual increase through to end‐stage disease. This suggests that there is a need for early detection of fALS cases, and potential therapeutic treatments may be more beneficial if administered at an early stage. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 1510–1519, 2001
Effects of lipid-lowering therapy on coronary artery remodeling

BackgroundAlthough lipid-lowering therapy affects the luminal size of atherosclerotic coronary arteries the role of vascular remodeling has not been systematically studied. Design/MethodsSerial three-dimensional volumetric intravascular ultrasound (IVUS) was used to study remodeling, which was defined as changes in arterial size independent of or dependent on changes in plaque size. Using an automated contour detection algorithm, a 1 mm segment of a moderate atherosclerotic lesion at the site of the maximal plaque volume at baseline was analysed. After 12 months the relationship between the absolute change in vessel volume and plaque volume was calculated in 99 patients. There was a significant relationship between changes in plaque and vessel volume, independent of plaque progression or plaque regression (decrease in plaque size, r=0.60, P<0.0001 and increase in plaque size, r=0.49, P<0.0008, respectively; the slopes of the regression equation were 1.03 and 0.80). By means of an analysis of covariance we tested whether the regression slopes were equal between groups of patients as defined by the low-density lipoprotein-cholesterol (LDL-c) level achieved with lipid-lowering therapy. ResultsOnly patients with plaque progression and a LDL-c level <100 mg/dl had a significantly smaller slope than patients with a LDL-c level>100 mg/dl (–0.14 compared with 1.14, P=0.003 ), indicating diminished coronary remodeling. ConclusionsSerial volumetric IVUS confirms the existence of both positive and negative remodeling in relation to an increase and decrease in plaque volume. It has been shown that the outward remodeling process is diminished in patients with plaque progression and intensive lipid-lowering therapy.
The Effect of the Internet on Wages

Who benefits from technology adoption in the workplace? To explore, I combine worker-level wage data with information on broadband adoption by Brazilian firms to estimate the effects of broadband on wages. Overall, wages increase 2.3 percent following broadband adoption. Consistent with the theory of biased technological change, wages increase the most for workers engaged in non-routine cognitive tasks and returns are negative for routine cognitive tasks. There is no effect of broadband adoption on wages for either routine or nonroutine manual tasks. Additionally, I estimate the effect of broadband on selected quantiles of the within-firm wage distribution and find evidence that within-firm wage inequality increases following broadband adoption. Both new hires and the firm’s existing employees benefit from broadband adoption, which indicates that broadband’s effects are not driven only by better recruitment of new employees. JEL Codes: J24, J31, O33 Email: chris.poliquin@anderson.ucla. edu I am grateful to Shane Greenstein, Michael Luca, Raffaella Sadun, and Deepak Malhotra for their advice and guidance. I also thank the HBS Latin America Research Center, Partners of the Americas, Harvard Business School, and the Harvard Economics Department for supporting this project.
Impact of presence of water tree and microcavities on the electric field distribution in XLPE insulation

The aim of this work is to investigate the influence of presence of water and air cavities close to the front of vented water tree growing from interior of semiconducting layer of power cable on the electric field distribution. For the determination of the electric field, a numerical method has been used under Comsol Multiphysics environment. This paper shows that, the presence of water tree induce a significant variation of electric field in the insulation. The electric field is amplified at the periphery of the water tree and in front of it; this effect is further enhanced if natural or created defects are present in the polymer in front of the water tree zone. The distribution of field may scarcely be affected by the number and the size of the micro-cavities, as well as the distance between water tree and these cavities. The increased enhancement of the field due to the presence of cavities of small diameters in regions either near the vented water tree can leads to the appearance of local electric fields higher than partial discharge inceptions and electrical treeing. Moreover, the initiation of electric tree is more probable in the case of water cavities than in the case of air cavities. The mutual interaction between cavities contributes much more to this apparition.
Os artigos publicados são de inteira responsabilidade de seus autores . As opiniões neles emitidas não exprimem , necessariamente , o ponto de vista da Fundação Getulio Vargas

I study a scoring auctions implemented in Brazil to sell oil exploration rights. Differently from most sales of this kind, bidders had to submit a multi-dimensional bid that included a bonus and an exploratory program. A non-linear scoring rule determined the winner. I propose a method to estimate the underlying primitive distribution of tract values and exploration commitment costs. Estimating the distribution of those primitives allows the evaluation of counterfactual revenues in alternative bidding schemes. I find that a first price auction would imply a 9.7% higher revenue from the sales examined. ∗FGV/EPGE Escola Brasileira de Economia e Finanças, e-mail: marcelo.santanna@fgv.br. I am grateful to Philip Haile for invaluable advice and support in this project. I thank John Asker, Steven Berry, Yuichi Kitamura, Vitor Luz, Camilla Roncoroni, Lorenzo Magnolfi and Yale I.O. Workshop participants for helpful comments. For sharing data on oil tract auctions, I thank Rodrigo Moura and Mauricio Pinheiro at FGV/IBRE. I thank Yale University and the Falk Fellowship Fund for financial support. All errors are my own.
Structure of Human Stabilin-1 Interacting Chitinase-like Protein (SI-CLP) Reveals a Saccharide-binding Cleft with Lower Sugar-binding Selectivity*

Human secreted protein stabilin-1 interacting chitinase-like protein (SI-CLP) has been identified as a novel member of Glyco_18 domain-containing proteins that is involved in host defense and inflammatory reactions. Efficient secretion of SI-CLP is mediated by its interaction with the endocytic/sorting receptor stabilin-1. SI-CLP is expressed abundantly in macrophages and neutrophils and is up-regulated by Th2 cytokine IL-4 and glucocorticoid, which suggest that SI-CLP could be a marker for adverse effects of glucocorticoid therapy. To gain insight into the biological function of SI-CLP, we determined the crystal structure of SI-CLP at 2.7 Å resolution by x-ray crystallography and found that it featured a typical triose-phosphate isomerase barrel fold with a putative saccharide-binding cleft. Comparison with other chitinase-like proteins showed the cleft to be atypically wide and open. The saccharide-binding capacity of SI-CLP was investigated, and its ligand-binding specificity was found to relate to the length of the oligosaccharides, with preference for chitotetraose. Further investigations reveal that SI-CLP could bind LPS in vitro and neutralize its endotoxin effect on macrophages. Our results demonstrate the saccharide-binding property of SI-CLP by structure and in vitro biochemical analyses and suggest the possible roles of SI-CLP in pathogen sensing and endotoxin neutralization.
Sphingomonas jeddahensis sp. nov., isolated from Saudi Arabian desert soil.

A novel Sphingomonas strain was isolated from a sample of desert soil collected near Jeddah in Saudi Arabia. A polyphasic approach was performed to characterize this strain, initially designated as G39T. Cells of strain G39T are motile, Gram-negative, catalase- and oxidase-positive. The strain is able to grow aerobically at 20-35 °C, pH 6.5-8 and tolerates up to 4 % (w/v) NaCl. Based on 16S rRNA gene sequence similarity, the closest relative type strains of G39T are Sphingomonas mucosissima DSM 17494T (98.6 %), S. dokdonensis DSM 21029T (98.4 %) and S. hankookensis DSM 23329T (97.4 %). Furthermore, the average nucleotide identities between the draft genome sequence of strain G39T and the genome sequences of all other available and related Sphingomonas species are significantly below the threshold of 94 %. The G+C content of the draft genome (3.12 Mbp) is 65.84 %. The prevalent (>5 %) cellular fatty acids of G39T were C18 : 1ω7c, C16 : 1ω7c and/or C16 : 1ω6c, C14 : 0 2-OH and C16 : 0. The only detectable respiratory quinone was ubiquinone-10 and the polar lipids profile is composed of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, sphingoglycolipid, as well as unidentified lipids, phospholipids and glycolipids. The results of the conducted polyphasic approach confirmed that this isolate represents a novel species of the genus Sphingomonas, for which the name Sphingomonas jeddahensis sp. nov. is proposed. The type strain of this species is G39T (=DSM 103790T=LMG 29955T).
Resonance frequency analysis of dental implants placed at the posterior maxilla varying the surface treatment only: A randomized clinical trial

Abstract Background Chemical modifications of the dental implant surface that improve the wettability result in a faster and better osseointegration. Purpose The aim of this randomized clinical trial was to evaluate the implant stability quotient (ISQ) of implants with similar designs, treated with 2 surfaces, sandblasted acid‐etched (SAE) and hydrophilic SAE, within the initial 16 weeks of healing. Material and methods A total of 64 implants (32 SAE—control group and 32 modified SAE—test group) with the same design, length, and diameter (conical and compressive, 4.3 × 10 mm) were inserted into the posterior maxillae of 21 patients partially edentulous. The ISQ values were collected at post‐surgery (T0), 1 week (T1), 2 weeks (T2), 3 weeks (T3), 5 weeks (T4), 8 weeks (T5), 12 weeks (T6), and 16 weeks (T7). Results None of the implants failed. Test group presented ISQ values higher than the control group (ANOVA—P < .01) from T5 to T7. When comparing groups regarding the amount of time required to achieve ISQ ≥ 70 as a reference, there was a statistically significant difference (cox regression—P < .01), and a hazard ratio of 2.24 (CI 1.62‐3.11). At the 1‐year follow‐up, there was a drop out of 1 patient, and 2 implants were no longer evaluated. Survival rate for both groups was 100% at the 1‐year follow‐up. Conclusions The current study suggests that implants with hydrophilic surface (modified SAE) integrate faster than implants with SAE surface. The stability gain of the test group was 2.24 times faster than the control group after 5 weeks of evaluation at the posterior region of the edentulous maxillae.
Clinical Evaluation of Percent Free Prostate–Specific Antigen Using the AxSYM System in the Best Analytical Scenario

Objective: Percent free prostate–specific antigen (PSA) is a promising tool for prostate cancer (CaP) diagnosis. However, its diagnostic performances have not yet been established. The present study was carried out with the aim of evaluating percent free PSA in the most favourable analytical conditions.Materials and Methods: Eighty–eight patients affected by newly diagnosed, untreated, primary CaP, and 169 cases with biopsy–confirmed, untreated, benign prostatic hypertrophy (BPH) were prospectively enrolled. Abbott AxSYM total and free PSA were measured by the same technician using the same instrument and the same reagent batch.Results: Percent free PSA was more effective than total PSA in differential diagnosis between CaP and BPH in every evaluated dose range of total PSA. In cases with total PSA >4 μg/l, percent free PSA could have reduced by about 50% the rate of unnecessary biopsies with a probably still acceptable 93% cancer detection rate. The likelihood of CaP after the determination of percent free PSA was in fact higher than 50% using cut–off points which provide low sensitivity values (i.e. 58% in men aged 50–59 years). Conclusions: Percent free PSA is superior to total PSA in distinguishing primary CaP from BPH in patients with total PSA between 2 and 30 μg/l and in reducing the rate of unnecessary biopsies in men with total PSA higher than 4 μg/l. However, percent free PSA should be cautiously interpreted in decision making in individual patients since post–test probability is relatively low in men aged 50–70 years.
Symmetry reversal in schizophrenia

Abstract Schizophrenia is associated with cortical asymmetries concentrated in the left fronto‐temporal hemisphere. In order to look for functional asymmetries between the two hemispheres, the stimulus–response times of patients were split into smaller periods and the interhemispheric and intrahemispheric correlations between these periods were investigated. Three groups were compared to each other: 22 patients with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, 4th edn; DSM‐IV) treated with neuroleptics; 24 psychiatric neuroleptic‐treated patients without schizophrenia; and 30 healthy subjects. All subjects were investigated by simple (one stimulus–one response) and complex (two stimuli–two responses), auditory and visual, right‐hemispheric and left‐hemispheric stimulus–response tasks. There were no intrahemispheric but significant interhemispheric correlations between the two auditory and between the two visual time fragments in both the healthy and the neuroleptic control group. In contrast there was a significant intrahemispheric correlation between the auditory and visual time fragment in the left hemisphere of patients with schizophrenia and no interhemispheric correlation between the auditory times. The reduction of the interhemispheric auditory correlation is interpreted as an auditory disintegration, the appearance of the left‐hemispheric audiovisual correlation as an audiovisual ‘hyperintegration’ in patients with schizophrenia. It is questionnable as to whether these findings are due to schizophrenia or to the neuroleptic treatment.
Prevalence and molecular analysis of macrolide-resistant Moraxella catarrhalis clinical isolates in Japan , following emergence of the highly macrolide-resistant strain NSH 1 in 2011

Correspondence Ryoichi Saito r-saito.mi@tmd.ac. jp Department of Microbiology and Immunology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan Department of Clinical Laboratory, Kimitsu Central Hospital, Chiba, Japan Department of Clinical Laboratory, Tokyo Metropolitan Health and Medical Corporation Toshima Hospital, Tokyo, Japan Clinical Laboratory Department, Nihon University Itabashi Hospital, Tokyo, Japan Clinical Laboratory Department, Nihon University Hospital, Tokyo, Japan