Miracle-dz/UniFAR-FTUs huggingface dataset:
Mathematical Modeling of the Hydrodynamic Forces on a Trawl Door

Precise control of trawl systems is assumed to be beneficial from both economic and environmental reasons. Using the trawl doors as actuators could increase the amount of available control forces. Adequate mathematical models of the hydrodynamic fores on the trawl doors are needed for control system design and verification. This paper presents a method for mathematical modeling of the hydrodynamic forces on the trawl doors. These forces are divided into steady-state forces and transient effects. The six degrees of freedom (six dof) steady-state hydrodynamic coefficients of a trawl door have been found as a function of its angles of attack and slip, based on wind-tunnel experiments. The coefficients are parameterized for smoothing and computational performance, and methods for extending the validity of the model in terms of orientation and trawl door shape are presented. The transient effects are described as functions of relative accelerations between the trawl door and the ambient water, angular velocities of the trawl door and circulation buildup. These effects are manifestations of variations in the flow around the trawl door and its wake, and a numerical method based on potential theory is employed to investigate them. A computational efficient, nonlinear, state-space model of the hydrodynamic forces is finally proposed. It accounts for steady-state and unsteady hydrodynamic forces and moments in six dof, suitable for trawl control system design and analysis
Switching Intravitreal anti-VEGF Treatment in Neovascular Age-Related Macular Degeneration

Purpose To compare the outcomes after switching between bevacizumab and ranibizumab therapy due to poor treatment effect in neovascular age-related macular degeneration (AMD). Methods This is a retrospective review of patients with neovascular AMD with first treatment using intravitreal bevacizumab (group 1) or ranibizumab (group 2) who switched to the other drug due to poor treatment effect. Primary outcome measures were change in mean best-corrected visual acuity (BCVA) and mean central retinal thickness (CRT) at 1 year and last visit. Results Eighty-seven eyes met the inclusion criteria. In group 1 (43 eyes), the mean BCVA decreased from 20/94 to 20/100 at 1 year after being switched (p = 0.573) and to 20/150 (p = 0.015) at final visit (mean 29.2 months, range 12-53). In group 2 (44 eyes), mean BCVA decreased from 20/72 to 20/90 (p = 0.401) and 20/100 (p = 0.081) at 1 year after switch and at final visit (mean 20.1 months, range 10-40), respectively. The mean CRT at switch, 1 year after switch, and at final visit were 344.4 ± 140 µm (mean ± SD), 286.26 ± 155 µm (p = 0.019), and 290.58 ± 196 µm (p = 0.009) in group 1 and 329.36 ± 144 µm, 302.0 ± 179 µm (p = 0.215), and 309.5 ± 220 µm (p = 0.154) in group 2, respectively. Conclusions The mean BCVA decreased over time in both groups; however, nearly 30% of the eyes in each group showed vision improvement after switching. Mean CRT decreased in both groups, which was more pronounced after being switched from bevacizumab to ranibizumab. In neovascular AMD, a switch between ranibizumab and bevacizumab can be considered as a further therapy option if poor treatment effect is seen with the initial therapy.
Energy exchange among base stations in a Cellular Network through the Smart Grid

In this paper, we study the problem of minimizing the energy cost incurred by a Cellular Network Operator (CNO) in a Smart Grid (SG) environment. We consider a CNO that deploys several Cellular Base Stations (CBS) to serve a given geographical area. Each CBS is equipped with a limited-capacity battery and can be powered either by the SG or by a renewable-energy (RE) harvester. Given this topology, two-way energy flow is allowed between each CBS and the SG and between any pair of CBSs in the network through the SG. The space-time-dependent energy-buying and energy-sharing costs and the energy-selling prices are made known to the CNO in advance. Therefore, in order to minimize the total cost incurred by the CNO, we find the optimal energy-management strategy by solving a constrained optimization problem. The proposed strategy ensures that the instantaneous energy demand of each CBS and the constraints imposed by each battery are satisfied at every point in time. We evaluate the performance of the proposed solution using simulations. Our results show that a significant cost reduction can be achieved by implementing the proposed strategy.
Half-squaring in responses of cat striate cells

Abstract Simple cells in striate cortex have been depicted as rectified linear operators, and complex cells have been depicted as energy mechanisms (constructed from the squared sums of linear operator outputs). This paper discusses two essential hypotheses of the linear/energy model: (1) that a cell's selectivity is due to an underlying (spatiotemporal and binocular) linear stage; and (2) that a cell's firing rate depends on the squared output of the underlying linear stage. This paper reviews physiological measurements of cat striate cell responses, and concludes that both of these hypotheses are supported by the data.
The prevalence of self-monitoring of blood glucose and costs of glucometer strips in a nationwide cohort.

OBJECTIVE This study used nationwide data to determine the prevalence of self-monitoring of blood glucose (SMBG) among all non-institutionalized persons living in Norway and to estimate the prevalence of SMBG among diabetes patients, the frequency and cost of SMBG, and the use of different glucometers. METHODS This retrospective, descriptive study is based on data of sales of glucometer strips to non-institutionalized persons in Norway in 2008. The data included gender, age group, month of purchase, sales place, type of strips, number of packages dispensed, and cost of strips. Additionally, statistics on sales of insulin and oral antidiabetes medications were obtained from the Norwegian Prescription Database. RESULTS A total of 96,999 persons purchased strips, a prevalence of 2%. Approximately 70% of diabetes patients practiced SMBG. An average patient used 1.7 strips per day, and younger patients purchased more strips than older patients. Fewer than 50% of patients performed glucose measurements daily. One percent of patients used more than 10 strips daily and was accountable for 8% of total costs. Most patients used only one type of strips, but the number of strips purchased increased with the number of different strips. The average annual cost of strips was 446 euro per person. CONCLUSIONS Two percent of all non-institutionalized inhabitants and an estimated 70% of patients using diabetes medication purchased SMBG strips. A small percentage of the patients incurred a substantial proportion of the costs. This, along with the fact that over half of the patients monitor less than once per day, calls for tighter follow-up of diabetes patients.
A growth reference for mid upper arm circumference for age among school age children and adolescents, and validation for mortality: growth curve construction and longitudinal cohort study

Objectives To construct growth curves for mid-upper-arm circumference (MUAC)-for-age z score for 5-19 year olds that accord with the World Health Organization growth standards, and to evaluate their discriminatory performance for subsequent mortality. Design Growth curve construction and longitudinal cohort study. Setting United States and international growth data, and cohorts in Kenya, Uganda, and Zimbabwe. Participants The Health Examination Survey (HES)/National Health and Nutrition Examination Survey (NHANES) US population datasets (age 5-25 years), which were used to construct the 2007 WHO growth reference for body mass index in this age group, were merged with an imputed dataset matching the distribution of the WHO 2006 growth standards age 2-6 years. Validation data were from 685 HIV infected children aged 5-17 years participating in the Antiretroviral Research for Watoto (ARROW) trial in Uganda and Zimbabwe; and 1741 children aged 5-13 years discharged from a rural Kenyan hospital (3.8% HIV infected). Both cohorts were followed-up for survival during one year. Main outcome measures Concordance with WHO 2006 growth standards at age 60 months and survival during one year according to MUAC-for-age and body mass index-for-age z scores. Results The new growth curves transitioned smoothly with WHO growth standards at age 5 years. MUAC-for-age z scores of −2 to −3 and less than−3, compared with −2 or more, was associated with hazard ratios for death within one year of 3.63 (95% confidence interval 0.90 to 14.7; P=0.07) and 11.1 (3.40 to 36.0; P<0.001), respectively, among ARROW trial participants; and 2.22 (1.01 to 4.9; P=0.04) and 5.15 (2.49 to 10.7; P<0.001), respectively, among Kenyan children after discharge from hospital. The AUCs for MUAC-for-age and body mass index-for-age z scores for discriminating subsequent mortality were 0.81 (95% confidence interval 0.70 to 0.92) and 0.75 (0.63 to 0.86) in the ARROW trial (absolute difference 0.06, 95% confidence interval −0.032 to 0.16; P=0.2) and 0.73 (0.65 to 0.80) and 0.58 (0.49 to 0.67), respectively, in Kenya (absolute difference in AUC 0.15, 0.07 to 0.23; P=0.0002). Conclusions The MUAC-for-age z score is at least as effective as the body mass index-for-age z score for assessing mortality risks associated with undernutrition among African school aged children and adolescents. MUAC can provide simplified screening and diagnosis within nutrition and HIV programmes, and in research.
Does Nutritional Supplementation Influence Adaptability of Muscle to Resistance Training in Men Aged 48 to 72 Years

Background and Purpose: Isotonic strength training can result in neuromuscular improvements evidenced in other forms of muscular effort, ie, isokinetic or isometric, especially in young subjects; however, it is unclear if older muscle maintains this same adaptive ability. Additionally, it is not known if the benefits of resistance training can be augmented by creatine and protein supplementation in older men. Therefore, the purpose of this study was to assess changes in isokinetic parameters at varying speeds in men aged 48 to 72 years (mean = 57 ± 2.1) following 16 weeks of isotonic resistance training and creatine and/or protein supplementation. Methods: Forty‐two male subjects were randomly assigned to 1 of 4 training groups: (1) resistance training placebo (n = 10), (2) resistance trained creatine supplemented (n = 10), (3) resistance trained protein supplemented (n = 11), and (4) resistance trained creatine and protein supplemented (n = 11). The program consisted of progressive overload resistance training (3 d/wk) and supplement consumption following the workout. Results: There were significant time effects (P ≤ .05) for peak torque (PT), time to PT, and average power for both the knee extensors and flexors at all velocities. However, no significant group or group by time interactions were noted, indicating that the supplementation protocols had no added benefits. Conclusions: Men aged 48 to 72 years maintained their ability to improve isokinetic muscle function following isotonic training, however, supplementation did not enhance muscle adaptability.
Cell‐surface expression of Hsp70 on hematopoietic cancer cells after inhibition of HDAC activity

We show that inhibition of HDAC activity leads to surface expression of Hsp70 on various hematopoietic cancer cells, an occurance that was not observed on naïve or activated peripheral blood cells. HDAC inhibitor‐mediated Hsp70 surface expression was confined to the apoptotic Annexin V‐positive cells and blocked by inhibition of apoptosis. Other chemotherapeutic inducers of apoptosis such as etoposide and camptothecin also led to a robust induction of Hsp70 surface expression. Hsp70 expression was, however, not caused by induction of apoptosis per se, as activated CD4 T cells remained Hsp70 surface‐negative despite effective induction of apoptosis. Interestingly, inhibition of endolysosomes or normal ER/Golgi transport did not affect Hsp70 surface expression. Intracellular calcium and the transcription factor Sp1, which has been shown previously to be important for the intracellular stress mediated by HDAC inhibitors, were not involved in Hsp70 surface expression. We also found that HDAC inhibitors decreased cellular PMET activity and that a selective inhibition of PMET activity with extracellular NADH induced a robust Hsp70 surface expression. Our data suggest that inhibition of HDAC activity selectively induces surface expression of Hsp70 on hematopoietic cancer cells and that this may increase immunorecognition of these cells.
Immediate single-tooth implants in the anterior maxilla: a 1-year case cohort study on hard and soft tissue response.

AIM The objective of the present study was to assess implant survival rate, hard and soft tissue response and aesthetic outcome 1 year after immediate placement and provisionalization of single-tooth implants in the pre-maxilla. All patients underwent the same strategy, that is mucoperiosteal flap elevation, immediate implant placement, insertion of a grafting material between the implant and the socket wall and the connection of a screw-retained provisional restoration. MATERIAL AND METHODS Thirty consecutive patients were treated for single-tooth replacement in the aesthetic zone by means of immediate implant placement and provisionalization. Reasons for tooth loss included caries, periodontitis or trauma. At 6 months, provisional crowns were replaced by the permanent ones. Clinical and radiographic evaluation was completed at 1, 3, 6 and 12 months to assess implant survival and complications, hard and soft tissue parameters and patient's aesthetic satisfaction. RESULTS One implant had failed at 1 month of follow-up, resulting in an implant survival rate of 97%. Radiographic examination yielded 0.98 mm mesial, respectively, 0.78 mm distal bone loss. Midfacial soft tissue recession and mesial/distal papilla shrinkage were 0.53, 0.41 and 0.31 mm, respectively. Patient's aesthetic satisfaction was 93%. CONCLUSIONS The preliminary results suggest that the proposed strategy can be considered to be a valuable treatment option in well-selected patients.
Changes in Upper-Extremity Functional Capacity and Daily Performance During Outpatient Occupational Therapy for People With Stroke.

OBJECTIVE This study explored how upper-extremity (UE) functional capacity and daily performance change during the course of outpatient rehabilitation in people with stroke. METHOD Fifteen participants receiving outpatient occupational therapy services for UE paresis poststroke were enrolled. UE motor capacity was measured with the Action Research Arm Test (ARAT), and UE performance was measured using bilateral, wrist-worn accelerometers. Measurements were taken at or near the start of therapy, at every 10th visit or every 30 days throughout the duration of services, and at discharge. RESULTS Three patterns were observed: (1) increase in ARAT scores and more normalized accelerometry profiles, (2) increase in ARAT scores but no change in accelerometry profiles, and (3) no change in ARAT scores or in accelerometry profiles. CONCLUSION UE performance in daily life was highly variable, with inconsistencies between change in UE capacity and change in UE performance. UE capacity and performance are important constructs to assess separately during rehabilitation.
Filaments and fingers: Novel structural aspects of the single septin from Chlamydomonas reinhardtii

Septins are filament-forming GTP-binding proteins involved in many essential cellular events related to cytoskeletal dynamics and maintenance. Septins can self-assemble into heterocomplexes, which polymerize into highly organized, cell membrane-interacting filaments. The number of septin genes varies among organisms, and although their structure and function have been thoroughly studied in opisthokonts (including animals and fungi), no structural studies have been reported for other organisms. This makes the single septin from Chlamydomonas (CrSEPT) a particularly attractive model for investigating whether functional homopolymeric septin filaments also exist. CrSEPT was detected at the base of the flagella in Chlamydomonas, suggesting that CrSEPT is involved in the formation of a membrane-diffusion barrier. Using transmission electron microscopy, we observed that recombinant CrSEPT forms long filaments with dimensions comparable with those of the canonical structure described for opisthokonts. The GTP-binding domain of CrSEPT purified as a nucleotide-free monomer that hydrolyzes GTP and readily binds its analog guanosine 5′-3-O-(thio)triphosphate. We also found that upon nucleotide binding, CrSEPT formed dimers that were stabilized by an interface involving the ligand (G-interface). Across this interface, one monomer supplied a catalytic arginine to the opposing subunit, greatly accelerating the rate of GTP hydrolysis. This is the first report of an arginine finger observed in a septin and suggests that CrSEPT may act as its own GTP-activating protein. The finger is conserved in all algal septin sequences, suggesting a possible correlation between the ability to form homopolymeric filaments and the accelerated rate of hydrolysis that it provides.
[The incidence and patterns of unintentional injuries in daily life in Korea: a nationwide study].

OBJECTIVES This study was conducted to estimate the cumulative incidence rate (CIR) of unintentional injuries in Korean daily life and to describe the pattern of unintentional injuries. METHODS The study population was the people who used the National Health Insurance because of injuries (ICD code: S00-T98) during 2006. The stratified sample according to gender, age and the severity of injury (NISS, New Injury Severity Score) was randomly selected. The questions on the questionnaire were developed as a reference for an international classification tool (ICECI, International Classification of External Causes of Injury). The questions included the locations of injury, the mechanisms of injury and the results of injury. Moreover, we used age, gender, region and income variables for analysis. RESULTS The CIR of unintentional injuries that occurred in daily life for 1 year per 100,000 persons was 17,606, and the CIR of severe injuries was 286. Many injuries were occurred at home (29.6%), public places (19.0%), school (13.7%) and near home (12.0%). The major mechanisms of injuries were slipping (48.8%), contact (14.0%), physical over-exertion (13.8%), and fall (6.6%). Infants and old aged people were vulnerable to injuries, and those who lived rural area and who were in a low income level were vulnerable too. CONCLUSIONS We signified the risk groups and risk settings of unintentional injuries in Korean daily life. These results could contribute to establishing strategies for injury prevention and implementing these strategies.
Preference for Hidden Income and Redistribution to Kin and Neighbors: A Lab-in-the-field Experiment in Senegal

Informal redistribution play a preponderant role in individual risk management in developing economies. However, strategies to reduce the pressure to redistribute are rather widespread and often costly, while under-explored in the economic literature. In this paper, we identify the potentially distortionary effects of informal redistribution on individual resource allocation choices, through exogenous variations on one hand of the share of unobservable income and on the other hand, of the pool of observers. For this, we conducted an original experiment combining both a lab-in-the-field and a randomized controlled trial in poor urban communities in Senegal on a randomly selected sample. A first contribution of the paper is to elicit in the lab the willingness-to-pay to hide one’s lab lottery gains from kin and neighbors. Second, we estimate the impact of the non-observability of this windfall income on resource allocation decisions of participants out of the lab. We find a high willingness-to-pay for hiding: 65% of subjects prefer to receive their gains in private rather than in public and among them, they are ready to forgo on average 14.3% of their unobserved income for the privacy option. Also, we find that the determinants of the willingness-to-pay to hide income while correlated with redistributive pressure differ across gender. Moreover, while lottery public winners are found to spend 22% of their windfall income on transfers to kin, lottery private winners showing preferences for hidden income transfer 24% less and reallocate this extra money in health and private expenditures.
Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers

The role of nitric oxide (NO) in migraine has been studied in the experimental glyceryl trinitrate (GTN)-infusion headache model. We hypothesized that GTN-induced headache may activate the trigeminovascular system and be associated with increased levels of sensory neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, vasoactive intestinal peptide (VIP), neuropeptide Y (NPY) and somatostatin plasma levels were measured before and after placebo/sumatriptan injection and during GTN-induced headache. Following a double-blind randomized cross-over design, 10 healthy volunteers received subcutaneous sumatriptan 6 mg or placebo. This was succeeded by 20 min of GTN (0.12 µg kg−1 min−1) infusion. At baseline no subject reported headache (using verbal rating scale from 0 to 10) and the jugular CGRP-like immunoreactivity (-LI) level was 18.6 ± 2.5 pmol/l. After a 20-min intravenous infusion of GTN 0.12 µg kg−1 min−1, median peak headache intensity was 4 (range 2–6) (P < 0.05), while jugular CGRP-LI levels were unchanged (19.0 ± 2.8 pmol/l; P > 0.05). There were no changes in VIP-, NPY- or somatostatin-LI. In conclusion, the NO donor GTN appears not to induce headache via immediate CGRP release.
Combined Estimation of Mercury Species Released from Amalgam

Amalgam fillings constitute, after food, the main source of exposure to mercury for the general population. Banning amalgam would incur huge costs for additional dental treatment. An evaluation of potential health risks must be based on the mercury dose released from fillings. In this study, dose is estimated by a new procedure of mercury speciation which elutes the released elemental and inorganic mercury with solvents of differing polarity. We tested the procedure by incubating spherical amalgam pellets in a mixture of light paraffin oil and saline (0.9% NaCl). Release of mercury into paraffin and saline was linear in relation to both amalgam surface area and exposure time. Measurements with this method were then extended to a group of 21 amalgam-bearing volunteers. The absorbed dose averaged 4.8 ug/day compared with 3.7 measured conventionally in intra-oral air from the same persons. With both methods, the dose was significantly correlated to the number of amalgam-covered tooth surfaces. This dose, combined with the nearly equal mercury uptake from food, is far below the acceptable daily intake limit.
Does News Travel Slowly Before a Market Crash? The Role of Margin Traders

We investigate how investor overconfidence and attention affect market efficiency around the 2015 Chinese stock market crash. We find that the price delay before the crash is about twice the price delay after the crash. Investors become more sensitive to market movements after the crash. Price delays are larger on market down‐days than on up‐days before the crash, but the differences are insignificant between up‐ and down‐days after the crash, indicating that negative information travels slowly only when investors are overconfident. Margin traders follow market trends and intensify the pyramiding and de‐pyramiding effects caused by market sentiment change.