Miracle-dz/UniFAR-FTUs huggingface dataset:
Multimedia of Educational Game for Disability Intellectual Learning Process: A Systematic Review

—Learning through play is an activity that is widely practiced in the current era. Educational or computer-based educational games in the learning process are not only entertaining but can also deepen relationships and enable greater learning processes. Multimedia educational games can help students to understand the material as long as the learning process looks more concrete and fun. Multimedia educational games in teaching and learning activities is also able to improve cognitive abilities possessed by individual intellectual disabilities, but their use is still rarely found. In this paper we conduct research in a systematic review of multimedia educational games as an aid in the implementation of the learning process for individuals with intellectual disabilities. The results of the study obtained from several literature indicate that multimedia educational game can be aimed at increasing the ability of individual intellectual disabilities in various ways not only in the academic field. The time needed during the use of multimedia educational games ranges from 20-60 minutes which is carried out in one full learning. The form of the game presented must be adapted to the real life of an intellectual disability individual in daily life and adapted to the abilities and obstacles that are possessed. The features provided must be able to support the ability of individual intellectual disabilities and can be used as material for improvement in the next learning process.
Comparing bimanual pelvic examination to ultrasound measurement for assessment of gestational age in the first trimester of pregnancy.

OBJECTIVE To compare the accuracy of bimanual pelvic examination to ultrasound in the assessment of gestational age and to evaluate resident and faculty accuracy, and residents' learning to perform pelvic examination. STUDY DESIGN Prospective, blinded, descriptive, correlational study of clinical bimanual examination versus ultrasound dating pregnancy prior to first-trimester abortion. Women scheduled to undergo abortion received transvaginal ultrasound assessment of gestational age. A resident and faculty physician, blinded to the ultrasound results, each performed a pelvic examination immediately prior to the procedure. The pelvic examination assessments were compared to the ultrasound calculations of gestational age. The absolute value of the difference between the bimanual examination and ultrasound dating were compared using the paired t test. Linear regression was used to evaluate the learning of residents. RESULTS The pelvic examination agreed with the ultrasound (+/- 2 weeks) in 92% of cases for faculty and 75% for residents. Accuracy of the resident examinations did not change over their two-month rotations. CONCLUSION If pelvic examination alone is used to assess gestational age in the setting of first-trimester abortion, 8% of patients may experience unnecessary interventions, possibly leading to a greater risk of complications.
T Cell Responses to an HLA-B*07-Restricted Epitope on the Dengue NS3 Protein Correlate with Disease Severity1

Dengue hemorrhagic fever (DHF), the severe manifestation of dengue virus (DV) infection characterized by plasma leakage, is more common in secondary DV infections in previously infected individuals and is associated with high levels of immune activation. To determine the Ag specificity of this immune response, we studied the response to an HLA-B*07-restricted T cell epitope, residues 221–232 of the DV NS3 protein, in 10 HLA-B*07+ Thai children who were studied during and after acute DV infections. Peptide-specific T cells were detected in 9 of 10 subjects. The frequency of peptide-specific T cells was higher in subjects who had experienced DHF than in those who had experienced DF. We also detected peptide-specific T cells in PBMC obtained at the time of the acute DV infection in 2 of 5 subjects. These data suggest that the NS3 (221–232) epitope is an important target of CD8+ T cells in secondary DV infection and that the activation and expansion of DV-specific T cells is greater in subjects with DHF than in those with dengue fever. These findings support the hypothesis that activation of DV-specific CD8+ T cells plays an important role in the pathogenesis of DHF.
Timing of paediatric deaths after trauma

We report a case of recurrent hypoglycaemia in a 64 year old woman with non-insulin dependent diabetes mellitus receiving formestane for metastatic breast carcinoma. She had previously been treated with surgery and local radiotherapy, followed by hormone manipulation with tamoxifen, medroxyprogesterone acetate, and then aminoglutethimide. All of these drugs had been poorly tolerated. She showed no signs of adrenal dysfunction when receiving aminoglutethimide, or subsequently. She had also received chemotherapy for relapse (variously cyclophosphamide, methotrexate, fluorouracil, epirubicin, mitomycin). She had been diabetic …
DEM Manipulation and 3-D Terrain Visualization: Techniques Used by the U.S. National Park Service

Manipulating digital elevation model (DEM) surfaces, like pliable modelling clay, enhances the appearance and legibility of 3-D topography on maps. The U.S. National Park Service (NPS) uses the familiar image-editing tools in Adobe Photoshop to manipulate raster DEM data. Exporting modified DEM data with the help of freeware and shareware utilities allows subsequent rendering of final 3-D scenes in Corel Bryce. Techniques to be discussed include topographic substitution – a method for reverse engineering present-day landscapes into the past or projecting them into the future; selective vertical exaggeration; resolution bumping – a technique developed specifically for improving the legibility of high-mountain landscapes; painting and filtering effects; and, borrowing from the traditional masters of landform depiction, creating 3-D scenes that emulate the panoramas of Heinrich Berann and the spherical over-the-horizon views of Richard Edes Harrison by warping the projection plane of DEMS. The unique challen.
Understanding target-driven action in emergency department performance using simulation

Many computer simulation models of emergency departments have been developed to aid clinicians and managers to maintain and improve the performance of their departments. A model is presented that can also be used to understand changes in performance that may occur as a result of the 4-hour target regime in the English NHS. The model simulates the performance resulting from normal activity, and the differences between this and actual performance are revealing. The results from two departments are presented to demonstrate this mode of model use. These reveal the extent of special action taken in some emergency departments as patients approach the target time, and also show the true underlying performance of the departments.
Glamour, value and anchoring on the changing P/E

The fact that value shares outperform glamour shares in the long term has been known for over 50 years. Why then do glamour shares remain popular? The price-earnings (P/E) ratio was the first statistic documented to discriminate between the two. Using data for all US stocks since 1983, we find that glamour shares have a much greater tendency to change P/E decile than value shares. We use TreeAge decision tree software, which has not been applied to problems in finance before, to show that glamour investors cannot rationally expect any windfall as their company's P/E decile changes, whatever their horizon. We infer that glamour investors anchor on the initially high P/E value, underestimate the likelihood of change and are continually surprised. We also seek theoretical justification for why value shares tend to outperform glamour shares. No convincing arguments based on the efficient market hypothesis have been put forward to show that the outperformance of value shares might be due to their being fundamentally riskier. Here, we apply equations from option theory to show that value shares can indeed be expected to outperform glamour shares.
Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion.

BACKGROUND & AIMS Postprandial hyperlipidemia is a risk factor for atherosclerotic heart disease and is associated with the consumption of high-fat diets and obesity. Bariatric surgeries result in superior and more durable weight loss than dieting. These surgeries are also associated with multiple metabolic improvements, including reduced plasma lipid levels. We investigated whether the beneficial effects of vertical sleeve gastrectomy (VSG) on plasma lipid levels are weight independent. METHODS VSG was performed on Long-Evans rats with diet-induced obesity. Controls were sham-operated animals who were either pair-fed or ad libitum-fed. We measured fasting and postprandial levels of plasma lipid. To determine hepatic and intestinal triglyceride secretion, we injected the lipase inhibitor poloxamer 407 alone or before oral lipid gavage. (13)C-Triolein was used to estimate postprandial uptake of lipid in the intestine. RESULTS Rats that received VSG and high-fat diets had markedly lower fasting levels of plasma triglyceride, cholesterol, and phospholipid than obese and lean (pair-fed) controls that were fed high-fat diets. Rats that received VSG had a marked, weight-independent reduction in secretion of intestinal triglycerides. VSG did not alter total intestinal triglyceride levels or size of the cholesterol storage pool nor did it affect the expression of genes in the intestine that control triglyceride metabolism and synthesis. VSG did not affect fasting secretion of triglyceride, liver weight, hepatic lipid storage, or transcription of genes that regulate hepatic lipid processing. CONCLUSIONS VSG reduced postprandial levels of plasma lipid, independently of body weight. This resulted from reduced intestinal secretion of triglycerides following ingestion of a lipid meal and indicates that VSG has important effects on metabolism.
Silencing the YB‐1 Gene Inhibits Cell Migration in Gastric Cancer In Vitro

The Y‐Box‐Binding Protein‐1 (YB‐1) is known to regulate the processes of transcription, translation, cellular response to drug treatment and viral infection as well as DNA repair among others. As gastric cancer is a common cancer with a high incidence in countries in Asia, we evaluated the association of YB‐1 with the malignant potential of gastric cancer cells in vitro. YB‐1 mRNA expression levels were first determined by real‐time RT‐PCR in two adherent gastric cancer cell lines (viz., MKN7 and NUGC3 gastric cancer cells) and a normal GES‐1 gastric epithelial cell line. Poorly differentiated NUGC3 gastric cancer cells were found to have the highest YB‐1 gene expression among the adherent cells. YB‐1 gene expression was also observed to be higher in non‐adherent SNU5 gastric cancer cells compared to more aggressive SNU16 cells. Silencing of the YB‐1 gene by siRNA in NUGC3 cells was associated with a significant reduction of the YB‐1 protein by more than 55% as verified by Western blot analysis. Down‐regulation of YB‐1 protein expression was further demonstrated qualitatively by immunocytochemistry and immunofluorescence staining. Silencing of the YB‐1 gene induced significant inhibition of cell migration in NUGC3 cells by 60% but did not influence cell invasion. Although epithelial‐mesenchymal‐transition (EMT) is known to be associated with the migratory phenotype in cancer cells, there was no change in the expression of EMT genes when YB‐1 expression was modulated. YB‐1 appears to have an integral role in cancer cell migration, a process which is important for gastric cancer metastasis. Anat Rec, 296:891–898, 2013. © 2013 Wiley Periodicals, Inc.
Adverse drug events in patients admitted to an emergency department: an analysis of direct costs

Several economic evaluations of adverse drug events (ADEs) exist, but the underlying methodology has not been standardized so far. The aim of the study was to combine prospective, intensive pharmacovigilance methods, and standardized accounting data to calculate direct costs of community‐acquired ADEs (caADEs) contributing to emergency department (ED) admission and subsequent hospitalization.
The molecular genetics of Usher syndrome

Association of sensorineural deafness and progressive retinitis pigmentosa with and without a vestibular abnormality is the hallmark of Usher syndrome and involves at least 12 loci among three different clinical subtypes. Genes identified for the more commonly inherited loci are USH2A (encoding usherin), MYO7A (encoding myosin VIIa), CDH23 (encoding cadherin 23), PCDH15 (encoding protocadherin 15), USH1C (encoding harmonin), USH3A (encoding clarin 1), and USH1G (encoding SANS). Transcripts from all these genes are found in many tissues/cell types other than the inner ear and retina, but all are uniquely critical for retinal and cochlear cell function. Many of these protein products have been demonstrated to have direct interactions with each other and perform an essential role in stereocilia homeostasis.
On Axis-Parallel Tests for Tensor Product Codes

O. Meir , SIAM J. Comput. 39, No. 2, 491–544 (2009; Zbl 1202.68235)]. We present two results on axis-parallel tests. (1) Bivariate low-degree testing with low agreement. We prove an analogue of the Bivariate Low-Degree Testing Theorem of Polishchuk and Spielman in the low-agreement regime, albeit for much larger ﬁelds. Namely, for the tensor product of the Reed-Solomon code with itself, we prove that for suﬃciently large ﬁelds, the 2-query variant of the axis-parallel line test (row-vs-column test) works for arbitrarily small agreement. Prior analyses of axis-parallel tests assumed high agreement, and no results for such tests in the low-agreement regime were known. Our proof technique deviates signiﬁcantly from that of Polishchuk and Spielman, which relies on algebraic methods such as Bézout’s Theorem, and instead leverages a fundamental result in extremal graph theory by Kővári, Sós, and Turán. To our knowledge, this is the ﬁrst time this result is used in the context of low-degree testing. (2) Improved robustness for tensor product codes. Robustness is a strengthening of local testability that underlies many applications. We prove that the axis-parallel hyperplane test for the m -th tensor power of a linear code with block length n and distance d is Ω( d m n m ) -robust. This improves on a theorem of Viderman Struct. Algorithms 46, No. 3, 572–598 (2015; Zbl 1316.94112)] by a factor of 1 / poly( m ) . While the improvement is not large, we believe that our proof is a notable simpliﬁcation compared to prior work.
Role Perceptions of Science Academics Who Teach to First-Year Students: The Influence of Gender.

A marked increase in student enrolments in South African public universities over the last two decades have admitted substantially more ‘non-traditional’ students to the sector. These students typically have unsatisfactory levels of school performance, lack communication skills (especially in English) and mostly have first-generation status. The Faculty of Science at the University of Johannesburg established its First Year Academy (FYA) in 2007. The FYA, a community of practice for first-year lecturers, promotes an optimal learning environment for students, and expects lecturers to adjust their usual facilitation of learning strategies. Not much is known (research-wise) about role adaptions that academics (in science environments) are expected (forced? ) to make in such circumstances. However, appropriate behaviours and expected competencies have to be interrogated if the faculty wants to continually enhance academic student success. A literature-validated Likert-type questionnaire involved 53 first-year lecturers (60% females). The survey gained perceptions in respect of eight possible roles that lecturers (could or should) play when dealing with first-year students, as well as their competence in fulfilling these roles. The MannWhitney U test revealed significant differences between perceived role importance and competence of males and females in respect of certain roles. Gender was found to significantly influence opinions and behaviours of science academics who teach to first-year students at University of Johannesburg (UJ). Capacity building geared at the more proficient execution of the roles of course designer, teacher, course manager and student consultant is regarded as vital and a tailor-made professional development program is planned for 2014.
Identification of Ca-rich dense granules in human platelets using scanning transmission X-ray microscopy

Whole mount (WM) platelet preparations followed by transmission electron microscopy (TEM) observation is the standard method currently used to assess dense granule (DG) deficiency (DGD). However, due to electron density-based contrast mechanism in TEM, other granules such as α-granules might cause false DGs detection. Herein, scanning transmission X-ray microscopy (STXM), was used to identify DGs and minimize false DGs detection of human platelets. STXM image stacks of human platelets were collected at the calcium (Ca) L2,3 absorption edge and then converted to optical density maps. Ca distribution maps obtained by subtracting the optical density map at pre-edge region from those obtained at post-edge region were used for identification of DGs based on richness of Ca. Dense granules were successfully detected by using STXM method without false detection based on Ca maps for 4 human platelets. Spectral analysis of granules in human platelets confirmed that DGs contained richer Ca content than other granules. Image analysis of Ca maps provided quantitative parameters which would be useful for developing image-based DG diagnosis models. Therefore, we would like to propose STXM as a promising approach for better DG identification and DGD diagnosis, as a complementary tool to the current WM TEM approach.
Factors determining job retention and return to work for disabled employees: a questionnaire study of opinions of disabled people's organizations in the UK.

OBJECTIVES To determine the views of organizations of and for disabled people in order to inform the writing of the British Society of Research Medicines policy document "Vocational Rehabilitation--The Way Forward". PATIENTS/ORGANIZATIONS: A single mailing was sent to 98 disability organizations within the UK. DESIGN A semi-structured postal questionnaire focused on factors (i) within the National Health Service; (ii) external to it, mainly in the workplace, making it difficult for people to stay in work in the presence of disease/disability, or to find work after losing their job (within the last 6 months). RESULTS A 30% response rate, with many incomplete questionnaires, was obtained so that 24 complete questionnaires were analysed. The dominant findings concerning the National Health Service were, overwhelmingly, that it was perceived as impacting deleteriously on the work of disabled people with delays to consultation, investigation and rehabilitation and a lack of appreciation of workplace issues. Employers were seen as unresponsive to the needs of workers, with negative attitudes to disability. The changes required in both areas were closely related to these findings. CONCLUSION Though the organizations surveyed were not representative, nevertheless there was considerable agreement about the need for both the National Health Service and employers to be more responsive to the workplace needs of disabled people.
MODERN METHODS OF BUNDLE ADJUSTMENT ON THE GPU

Abstract. The task to compute 3D reconstructions from large amounts of data has become an active field of research within the last years. Based on an initial estimate provided by structure from motion, bundle adjustment seeks to find a solution that is optimal for all cameras and 3D points. The corresponding nonlinear optimization problem is usually solved by the Levenberg-Marquardt algorithm combined with conjugate gradient descent. While many adaptations and extensions to the classical bundle adjustment approach have been proposed, only few works consider the acceleration potentials of GPU systems. This paper elaborates the possibilities of time and space savings when fitting the implementation strategy to the terms and requirements of realizing a bundler on heterogeneous CPUGPU systems. Instead of focusing on the standard approach of Levenberg-Marquardt optimization alone, nonlinear conjugate gradient descent and alternating resection-intersection are studied as two alternatives. The experiments show that in particular alternating resection-intersection reaches low error rates very fast, but converges to larger error rates than Levenberg-Marquardt. PBA, as one of the current state-of-the-art bundlers, converges slower in 50 % of the test cases and needs 1.5-2 times more memory than the Levenberg- Marquardt implementation.
Holistic and Change-centric Model for Web Service Evolution

Under the constantly evolving requirements from the consumers and competition pressure from the peers, Web Service providers are always striving to improve their services through publishing new versions. As more enterprises choose to embrace SOA, the frequent updates of Web services and increasing distributed environments have resulted in major challenges for all stakeholders to address the evolution of the Web service As a result, lots of solutions have been proposed to deal with the issues caused by Web Service evolution such as models, monitor, analysis, versioning, adaptation, and execution. However, few of them concentrate on the solution that covers all the evolution-related issue under one holistic model which explains 1) what has been changed, 2) when the changes occur, 3) how to apply changes, and 4) how to react to the changes. In this article, we present a change-centric model for Web Service evolution and explain how it deals with the evolution-related issues.
Cdc25C expression in meiotically competent and incompetent goat oocytes

Change in Cdc25C expression and localization during maturation and meiotic competence acquisition was investigated in goat oocytes. Western blot analysis revealed that Cdc25C is constitutively expressed throughout meiosis in competent goat oocytes, with changes in its phosphorylation level. Cdc25C was detected at 55 and 70 kDa, representing the nonphosphorylated form and the hyperphosphorylated active form, respectively. During the G2‐M transition at meiosis resumption, Cdc25C was hyperphosphorylated as evidenced by a clear shift from 55 to 70 kDa. Okadaic acid which induced premature meiosis resumption associated with MPF activation also involved a premature shift from 55 to 70 kDa in goat competent oocytes. After artificial activation of goat oocytes, Cdc25C returned to its 55 kDa form. By indirect immunofluorescence, Cdc25C was found essentially localized in the nucleus at the germinal vesicle stage, suggesting that Cdc25C functions within the nucleus to regulate MPF activation. Concomitantly with germinal vesicle breakdown, Cdc25C was redistributed throughout the cytoplasm. The amount of Cdc25C, very low in incompetent oocytes, increased with meiosis competence acquisition. On the other hand, during oocyte growth while the expression of Cdc25C increased, its phosphorylation level increased concomitantly as well as its nuclear translocation. These results suggest that meiosis resumption needs a sufficient amount of Cdc25C which must be completely phosphorylated and nuclear and that the amount of Cdc25C may be a limiting factor for meiotic competence acquisition. We could consider that Cdc25C nuclear translocation and phosphorylation, during oocyte growth, prepare the oocytes in advance for the G2‐M phase transition occurring during meiosis resumption. Mol. Reprod. Dev. 62: 4‐12, 2002. © 2002 Wiley‐Liss, Inc.