Miracle-dz/UniFAR-FTUs huggingface dataset:
Nearest neighbor sampling for cross company defect predictors: abstract only

Several research in defect prediction focus on building models with available local data (i.e. within company predictors). To employ these models, a company should have a data repository, where project metrics and defect information from past projects are stored. However, few companies apply this practice. In a recent work, we have shown that cross company data can be used for building predictors with the cost of increased false alarms. Thus, we argued that the practical application of cross-company predictors is limited to mission critical projects and companies should starve for local data. In this paper, we show that nearest neighbor (NN) sampling of cross-company data removes the increased false alarm rates. We conclude that cross company defect predictors can be practical tools with NN sampling, yet local predictors are still the best and companies should keep starving for local data.
The Epithelial Sodium Channel (ENaC) Traffics to Apical Membrane in Lipid Rafts in Mouse Cortical Collecting Duct Cells*

We previously showed that ENaC is present in lipid rafts in A6 cells, a Xenopus kidney cell line. We now demonstrate that ENaC can be detected in lipid rafts in mouse cortical collecting duct (MPKCCD14) cells by detergent insolubility, buoyancy on density gradients using two distinct approaches, and colocalization with caveolin 1. Less than 30% of ENaC subunits were found in raft fractions. The channel subunits also colocalized on sucrose gradients with known vesicle targeting and fusion proteins syntaxin 1A, Vamp 2, and SNAP23. Hormonal stimulation of ENaC activity by either forskolin or aldosterone, short or long term, did not alter the lipid raft distribution of ENaC. Methyl-β-cyclodextrin added apically to MPKCCD14 cells resulted in a slow decline in amiloride-sensitive sodium transport with short circuit current reductions of 38.1 ± 9.6% after 60 min. The slow decline in ENaC activity in response to apical cyclodextrin was identical to the rate of decline seen when protein synthesis was inhibited by cycloheximide. Apical biotinylation of MPKCCD14 cells confirmed the loss of ENaC at the cell surface following cyclodextrin treatment. Acute stimulation of the recycling pool of ENaC was unaffected by apical cyclodextrin application. Expression of dominant negative caveolin isoforms (CAV1-eGFP and CAV3-DGV) which disrupt caveolae, reduced basal ENaC currents by 72.3 and 78.2%, respectively; but, as with cyclodextrin, the acute response to forskolin was unaffected. We conclude that ENaC is present in and regulated by lipid rafts. The data are consistent with a model in which rafts mediate the constitutive apical delivery of ENaC.
Controllable Abstractive Summarization

Current models for document summarization disregard user preferences such as the desired length, style, the entities that the user might be interested in, or how much of the document the user has already read. We present a neural summarization model with a simple but effective mechanism to enable users to specify these high level attributes in order to control the shape of the final summaries to better suit their needs. With user input, our system can produce high quality summaries that follow user preferences. Without user input, we set the control variables automatically – on the full text CNN-Dailymail dataset, we outperform state of the art abstractive systems (both in terms of F1-ROUGE1 40.38 vs. 39.53 F1-ROUGE and human evaluation.
A Glimmer of Optimism in Government Savings Accumulation? An Empirical Examination of Municipal Unassigned Fund Balance in Florida

Few would question that the Great Recession and its aftermath have proved challenging for government financial management. This depressed economic environment has renewed interest in research involving the accumulation and use of the unassigned fund balance. In this study, we use data on Florida cities to examine the factors affecting the unassigned fund balance before, during, and after the Great Recession. According to our findings, building and maintaining savings at high levels have become routine for Florida cities, irrespective of their government form and the economic conditions they face. This research also provides evidence that Florida cities adapt their savings accumulation strategy, depending on the level of unassigned fund balance they are targeting. As a result, Florida cities consider different factors when accumulating unassigned fund balance above, rather than within or below, the minimum range suggested by the Government Finance Officers Association.
Regional Localization of Immunoreactive c-fos and Prolactin in Human Endometrium during the Normal Menstrual Cycle

The objective of the present study was to evaluate the cyclic changes and regional localization of immunoreactive c-fos and prolactin (PRL) in the human endometrium, using immunohistochemistry. Immunoreactive PRL was found in the epithelium of 9.1% of the proliferative specimens and in 55.6% of the secretory specimens (p < 0.05, Fisher’s exact test). In the endometrial stroma, immunoreactive PRL was present in 9.1 and 66.7% of the proliferative and secretory samples, respectively (p < 0.01). Immunoreactive c-fos predominated in the stroma and was identified in 54.5% of the specimens in the proliferative phase, but in only 7.1% of those in the secretory phase (p < 0.05). The progesterone/estradiol ratio was lower in the patients expressing immunoreactive c-fos (median = 13.1 ng/ml) compared to those who did not (median = 84.5 ng/ml, p < 0.05). We conclude that immunoreactive c-fos is found mostly in stromal cells during the proliferative phase of the menstrual cycle, and is sharply reduced during the secretory phase, when the endometrium is under progesterone stimulation – attested by PRL production.
Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway

Chikungunya virus (CHIKV), the causative agent of a major epidemic spanning five continents, is a positive stranded mRNA virus that replicates using the cell’s cap-dependent translation machinery. Despite viral infection inhibiting mTOR, a metabolic sensor controls cap-dependent translation, viral proteins are efficiently translated. Rapalog treatment, silencing of mtor or raptor genes, but not rictor, further enhanced CHIKV infection in culture cells. Using biochemical assays and real time imaging, we demonstrate that this effect is independent of autophagy or type I interferon production. Providing in vivo evidence for the relevance of our findings, mice treated with mTORC1 inhibitors exhibited increased lethality and showed a higher sensitivity to CHIKV. A systematic evaluation of the viral life cycle indicated that inhibition of mTORC1 has a specific positive effect on viral proteins, enhancing viral replication by increasing the translation of both structural and nonstructural proteins. Molecular analysis defined a role for phosphatidylinositol-3 kinase (PI3K) and MAP kinase-activated protein kinase (MnKs) activation, leading to the hyper-phosphorylation of eIF4E. Finally, we demonstrated that in the context of CHIKV inhibition of mTORC1, viral replication is prioritized over host translation via a similar mechanism. Our study reveals an unexpected bypass pathway by which CHIKV protein translation overcomes viral induced mTORC1 inhibition.
The influence of commercial-grade carpet on postural sway and balance strategy among older adults.

PURPOSE The purpose of this research study was to examine the effect of a selected commercial-grade carpet on the static balance of healthy, older adults who had not fallen more than twice in the last 6 months. DESIGN AND METHODS We tested a total of 45 participants. Each participant stood on a computerized balance machine and was subjected to a carpeted versus a noncarpeted condition while exposed to various sensory limitations. We measured both postural sway and balance strategy. RESULTS The selected commercial-grade carpet did not affect postural sway. The participants were able to adapt to the sensory limitations regardless of whether they were standing on the carpet. Although balance strategy scores were significantly lower during the carpeted conditions, the clinical significance was questionable as the difference between the means was small for practical purposes. IMPLICATIONS Healthy, older adults did not have difficulty maintaining static balance on the carpeted surface; however, the results could be different if participants who had a history of falling had been included. The results from this study are important and provide a basis of comparison for those individuals who have experienced more than two falls in the last 6 months or who have a history of falling.
Intravoxel incoherent motion diffusion-weighted MR imaging of the liver using respiratory-cardiac double triggering

To investigate the influence of respiratory-cardiac double triggering (RCT) on intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for the liver, twelve healthy volunteers underwent liver DWI twice respectively with respiratory triggering (RT) and RCT schemes. Signal-to-noise ratios (SNRs) of the images, values, repeatability (evaluating with within-subject coefficient of variation), and variability of quantitative parameters, including apparent diffusion coefficient (ADC), pure diffusion coefficient (D), perfusion fraction (f), and perfusion-related diffusion coefficient (D*), were evaluated for each DWI sequence. Results showed that the use of RCT scheme significantly enhanced SNRs (P < 0.001), improved the measurement precision (P ≤ 0.023) and repeatability (P ≤ 0.009) of ADC, D, and f values, decreased the variability of ADC and D values (P ≤ 0.015). Furthermore, this improvement was not completely confined to the left liver lobe, but also observed for the right liver lobe. Moreover, the precision of D* values in the right lobe (P < 0.001) and its repeatability in the left lobe (P = 0.002) were also significantly improved. Thus, our findings suggest that RCT is a more effective physiological scheme for improving SNRs, the precision, repeatability, and variability of quantitative parameters than RT for IVIM-DWI in the liver.
Building a Better Speed Trap

A comparative approach to studying the spread of policy innovations has recently yielded new and interesting results, as well as theoretical advancements, for policy diffusion research. Specifically, punctuated equilibrium theory has been offered as an explanation for why some policies spread quickly, while others do so normally, and still others are adopted very slowly. Studies of adoption speed, however, currently rely on careful case selection or a dichotomous categorization of adoptions as fast or slow to test why policies diffuse at different speeds. Building on this foundational work, I propose a method for measuring adoption speed as a continuous concept, so that it can be modeled directly as an important outcome of interest to diffusion scholars. I then use the new measure to evaluate how adoption speed varies across time and policy domain. I further demonstrate the utility of the measure as a dependent variable by replicating past results, including the interactive effect of complexity and salience on adoption speed and positive effect of federal incentives, as well as finding preliminary evidence that policy clusters spread more rapidly than the average stand-alone policy.
Ultrasonographic findings in placenta increta.

Placenta increta, invasion of the myometrium by normal placental (chorionic) villi, can be life‐threatening to a mother at delivery. In two reported cases of pathologically proven placenta increta, the abnormal areas were retrospectively identified on ultrasonographic images. In both cases, there was consistent focal obliteration of the hypoechoic retroplacental zone by either tissue of echogenicity similar to that of the normal placenta or tissue of slightly decreased echogenicity. This was found to represent extension of the villi through the decidua basalis into the myometrium. The spectrum of non‐malignant invasive placentas and the specific ultrasonographic findings that should allow prospective diagnosis are discussed.
On the resolution of inhomogeneous norm form equations in two dominating variables

Applying Baker's well-known method and the reduction procedure described by Baker and Davenport, we give a numerical algorithm for finding all solutions of inhomogeneous Thue equations of type NK/Q(x + ay + X) = 1 in the variables x, y e Z and A e Zic with | A | < (max \x\, \y\))ll2, where K = Q(a) is a totally real cubic field.
Vitamin E protects against polymorphonuclear leukocyte‐dependent adhesion to endothelial cells

We evaluated the effects of α‐Toc on surface expression of CD11b/CD18 on polymorphonuclear leukocytes (PMN) stimulated with N‐formyl‐methionyl‐leucyl‐phenylalanine (fMLP) and oxidized low‐density lipoprotein (oxLDL). Incubation of PMN with fMLP (1 μM) or oxLDL (100 μg/mL) increased CD11b/CD18 expression; pretreatment with α‐Toc reduced in a dose‐dependent manner. PMN obtained from healthy adults ingesting 600 mg α‐Toc per day for 10 days were similarly incubated with fMLP or oxLDL; the surface level of CD11b/CD18 was inversely correlated with serum α‐Toc concentrations. Adherence of PMN to human umbilical vein endothelial cells was increased by fMLP or oxLDL stimulation but reduced by α‐Toc pretreatment or anti‐CD18 monoclonal antibodies. cAMP‐dependent protein kinase (PKA) and protein kinase C (PKC) activity in PMN was also assayed. A PKC inhibitor, but not a PKA inhibitor, suppressed CD11b/CD18 up‐regulation, and α‐Toc slightly decreased fMLP‐ and oxLDL‐induced activation of PKC. These results suggest that α‐Toc may prevent inflammation by both reducing CD11b/CD18 up‐regulation and decreasing PMN‐dependent adherence to EC. J. Leukoc. Biol. 65: 757–763; 1999.
Mucoadhesive buccal films of glibenclamide: Development and evaluation

Background: Glibenclamide is an oral hypoglycemic drug completely metabolized in the liver, the principal metabolite being very weakly active, buccal delivery may be useful for the treatment of diabetes more effectively. The aim of the present study was to design formulations and systematically evaluate in vitro and ex vivo performances of buccal films of glibenclamide so that the required therapeutic plasma concentrations can possibly be achieved more rapidly using the different grades of hydroxypropyl methyl cellulose (HPMC) as the base matrix. Materials and Methods: Mucoadhesive buccal films of glibenclamide were prepared by solvent casting technique using different grades of HPMC with different ratios. Prepared films were evaluated for weight, thickness, surface pH, swelling index (SI), folding endurance, drug content uniformity, in vitro release, and ex vivo permeation studies. Results: The film thickness and weight were in the range of 0.213–0.4892mm and 22.25–39.83 mg, respectively. The films exhibited controlled release over more than 6 h. HPMC, HPMCK100, and HPMC3000 films exhibited satisfactory swelling. Surface pH of buccal films was found to be 6.4–6.8. SI observed to be highest for GF12 (275.3 ± 12.17) and lowest for GF1 (173.5 ± 5.65). The films exhibited controlled release over more than 6 h. HPMC exhibited satisfactory swelling, an optimum residence time, and promising drug release. The Higuchi plots were found to be linear with correlation coefficient values of 0.8933, 0.9138, and 0.9947 for GF4, GF8, and GF9, respectively. Conclusions: Among all the formulations, GF9 shows good controlled release results correlated with ex vivo permeation studies.
Effects of changes in lung volume on oscillatory flow rate during high-frequency chest wall oscillation.

BACKGROUND The effectiveness of high-frequency chest wall oscillation (HFCWO) in mucolysis and mucous clearance is thought to be dependant on oscillatory flow rate (Fosc). Therefore, increasing Fosc during HFCWO may have a clinical benefit. OBJECTIVES To examine effects of continuous positive airway pressure (CPAP) on Fosc at two oscillation frequencies in healthy subjects and patients with airway obstruction. METHODS Five healthy subjects and six patients with airway obstruction underwent 12 randomized trials of HFCWO (CPAP levels of 0 cm H2O, 2 cm H2O, 4 cm H2O, 6 cm H2O, 8 cm H2O and 10 cm H2O at frequencies of 10 Hz and 15 Hz) within a body plethysmograph, allowing measurements of changes in lung volume. Fosc was measured by reverse plethysmography using a 20 L isothermic chamber near the mouth. At the end of each randomized trial, an inspiratory capacity manoeuvre was used to determine end-expiratory lung volume (EELV). RESULTS EELV increased significantly (P<0.05) with each level of CPAP regardless of oscillation frequency. Fosc also significantly increased with CPAP (P<0.05) and it was correlated with EELV (r=0.7935, P<0.05) in obstructed patients but not in healthy subjects (r=0.125, P=0.343). There were no significant differences in perceived comfort across the levels of CPAP. CONCLUSIONS Significant increases in Fosc with CPAP-induced increases in lung volume were observed, suggesting that CPAP may be useful as a therapeutic adjunct in patients who have obstructive airway disease and who require HFCWO.
ANXIETY DISORDERS ARE INDEPENDENTLY ASSOCIATED WITH SUICIDE IDEATION AND ATTEMPTS: PROPENSITY SCORE MATCHING IN TWO EPIDEMIOLOGICAL SAMPLES

Research suggests that suicidal behavior in individuals with anxiety disorders is attributable to cooccurring risk factors, such as depression. We argue that these conclusions are founded primarily in statistical adjustments that may obscure independent associations. We explored independent associations between specific anxiety disorders and suicide attempts and ideation by means of propensity score matching, a process that simulates a case‐control study by creating matched groups that differ in group status (e.g., diagnosis of a specific anxiety disorder) but that are statistically equivalent on observed covariates.
No effect of carbohydrate-protein on cycling performance and indices of recovery.

PURPOSE The aim of this study was to determine whether adding protein to a CHO beverage would improve late-exercise cycle time-trial performance over CHO alone. Furthermore, we examined the effects of coingesting protein with CHO during exercise on postexercise markers of sarcolemmal disruption and the recovery of muscle function. METHODS In a double-blind, crossover design, 12 trained male cyclists performed 120 min of steady-state (SS) cycling at approximately 55% VO2max followed by a time trial lasting approximately 1 h. At 15-min intervals during SS exercise, participants consumed either a CHO or a CHO + protein (CHO + Pro) beverage (providing 65 g x h(-1) CHO or 65 g x h(-1) CHO plus 19 g x h(-1) protein). Twenty-four hours after the onset of the SS cycle, participants completed a maximum isometric strength test. At rest and 24 h postexercise, a visual analog scale was used to determine lower-limb muscle soreness, and blood samples were obtained for plasma creatine kinase concentration. Dietary control was implemented 24 h before and during the time course of each trial. RESULTS Average power output sustained during time trial was similar for CHO and CHO + Pro, with no effect of treatment on the time to complete the time trial (60:13 +/- 1:33 and 60:51 +/- 2:40 (min:s) for CHO and CHO + Pro, respectively). Postexercise isometric strength significantly declined for CHO (15% +/- 3%) and CHO + Pro (11% +/- 3%) compared with baseline (486 +/- 28 N). Plasma creatine kinase concentrations, and visual analog scale soreness significantly increased at 24 h postexercise, with no difference between treatments. CONCLUSIONS The present findings suggest that CHO + Pro coingestion during exercise does not improve late-exercise time-trial performance, ameliorate markers of sarcolemmal disruption, or enhance the recovery of muscle function at 24 h postexercise over CHO alone.
The Work-Related Quality of Life scale for healthcare workers.

AIM This paper is a report of a study to develop and test the psychometric properties of the Work-Related Quality of Life scale for healthcare workers. BACKGROUND As problems associated with stress and job satisfaction are evident for healthcare workers and nurses, a reliable tool to assess employees' quality of working life is required. However, previous research has produced inconsistent factor structures and inadequate psychometric properties for a range of quality of working life measures. This new scale expands the concept of quality of working life by incorporating a broad six-factor structure derived from a theoretical review of the field. METHOD We used data from a 2003 survey of 953 healthcare workers. Eighty-six per cent of the sample is female and 36% had been employed by the organization for 1-5 years. Approximately 50% of workers were employed full-time. FINDINGS Both exploratory and confirmatory factor analysis using split-half data sets produced a good fit and a reliable 23-item, six-factor measurement model of Work-Related Quality of Life. The factors generated were labelled: Job and Career Satisfaction, General Well-Being, Home-Work Interface, Stress at Work, Control at Work and Working Conditions. CONCLUSION The Work-Related Quality of Life measure is one of the most succinct yet psychometrically valid and reliable Quality of Working Life scales in the literature. We propose that it can appropriately be used in healthcare organizations to assess quality of working life. Further research is required to refine the instrument and assess its applicability to other areas.
Does thalidomide prolong survival in dogs with splenic haemangiosarcoma?

OBJECTIVES To investigate thalidomide as an adjuvant treatment for canine haemangiosarcoma. MATERIALS AND METHODS Fifteen dogs with splenic haemangiosarcoma, initially treated by splenectomy, were included. Following recovery from surgery, all dogs received thalidomide continuously until their death. Tumour stage was established using CT scans of the chest and abdomen immediately before starting thalidomide treatment and again three months later. Cause of death was confirmed by post mortem examination. RESULTS The median survival time of dogs receiving thalidomide was 172 days (95% confidence interval: 93 to 250 days). Five dogs (33% of the population receiving thalidomide) survived more than 1 year (range 458 to 660 days) after surgery. Dogs with stage 2 disease that received thalidomide also had a longer survival time than dogs with stage 3 disease (median survival time 303 versus 40 days). Of 15 dogs, 13 died from metastatic haemangiosarcoma. CLINICAL SIGNIFICANCE Treatment using thalidomide may improve survival of dogs with splenic haemangiosarcoma and should be considered a possible adjuvant therapy.