Miracle-dz/UniFAR-FTUs huggingface dataset:
Sporadic multiple primary melanoma cases: CDKN2A germline mutations with a founder effect

Multiple primary cancers are one of the hallmarks of inherited predisposition. Outside the familial context, multiple primary tumors could be related either to germline de novo mutations or to low‐penetrance mutations, in predisposing genes. We selected 100 patients who displayed multiple primary melanoma (MPM) without any known melanoma cases recorded within their families and looked for germline mutations in the two melanoma‐predisposing genes identified to date, CDKN2A and CDK4 exon 2. Nine patients (9%) had germline mutations in CDKN2A, whereas none carried germline mutations in exon 2 of CDK4. Seven cases displayed a recurrent missense mutation, G101W, already described in more than 20 melanoma‐prone families; one case carried a missense mutation never reported to date (P114S), and the last case was a carrier of a 6 bp insertion at nucleotide 57 resulting in a duplication of codons 18 and 19. To ascertain whether the G101W was a mutational hot spot for de novo mutations or a common founder mutation, we genotyped eight microsatellite markers flanking the CDKN2A gene. After allowing for recombination over time, haplotype sharing provided evidence for an original G101W mutation common to 6 out of 7 sporadic MPM cases. Therefore, it can be concluded that de novo germline CDKN2A mutations associated with MPM are rare. © 2001 Wiley‐Liss, Inc.
Prevalence of Scabies Among School Children in a Rural Block of Coastal Karnataka.

A survey for scabies was conducted in 14 primary-and 2 high schools of one rural block of Dakshina Kannada district on the west coast of Karnatak from November 1982 to March 1983. A total of 5,128 (84.9%) out of the 6,041 registered children were examined. Prevalence of scabies among children aged 6 to 15 years was 8.2%, prevalence was higher among boys than girls; higher among children of backward communities than those of other communities- and higher among Muslims than among Hindus. History of another case of scabies at home was found in 37.37o of the cases.Secondary pyoderma was observed in 16.59'o of the, cases. Distribution of Lesions conformed to the pattern described in other studies. Results of follow-up after 3-5 weeks of treatment with 25% benzyl benzoate are also reported.
Clinical characteristics and factors affecting growth in long-term survivors of cancer.

We evaluated clinical characteristics and growth in 51 (24 males) long-term survivors of childhood cancer (median follow up 12.7 years). Patients were shorter, had a higher proportion of body fat and higher systolic blood pressure than their controls. The change in relative height during treatment was -0.83 standard deviation score (S.D.S.) in patients with cranial irradiation and -0.32 S.D. S. in patients without cranial irradiation; the figures after treatment were -0.56 and 0.20 S.D. S. , respectively. Half (r2 = 0.50) of the variation in growth retardation during therapy could be explained by the cumulative doses of 6-mercaptopurine (6-MP) and vincristine and relative height at diagnosis. Cranial irradiation, increased relative height at diagnosis and young age at diagnosis were significant predictors of growth failure over the total observation period, explaining 43% of the variation. We conclude that long-term survivors of childhood cancer have impaired linear growth, increased body fat mass and elevated systolic blood pressure. Young children who are tall for their age at diagnosis and treated with cranial irradiation have the highest risk of impaired growth after the diagnosis. High doses of 6-MP seem to contribute significantly to growth retardation during therapy.
Roll-to-Roll Process-Based Sub-Wavelength Grating for a Color-Separation Backlight

For this study, we designed a color-separation backlight to avoid the use of absorptive color filters in a conventional backlight. The module consists of sub-wavelength grating on a light-bar (SWG-LB) and a cylindrical lens array on a V-grooved light guide to display R/B/G images more efficiently. We designed the light bar to be a hexagon type in which partial total internal reflection (TIR) area is uniformly spaced between each SWG. The measurements showed that uniformity from the light bar and NTSC are 92.8% and 99%, respectively. The optical components including the sub-wavelength grating and the cylindrical lens array were mass produced, and the diamond turning was produced using a roll-to-roll process.
Absence of combined effects of anemia and bilateral surgical status on inpatient rehabilitation outcomes following total knee arthroplasty

Purpose. To examine the effects of anemia on inpatient rehabilitation outcomes following unilateral and bilateral total knee arthroplasty (TKA). Method. This was a multicenter, retrospective study from 15 inpatient rehabilitation facilities. Patients (N = 5421) with very low hematocrit (Hct <30%), low Hct (30–36% women, 30–41% men), or normal Hct (>36% women, 41% men) were included. Inpatient rehabilitation occurred following TKA. Functional independence measure (FIM) scores, length of stay (LOS), itemized hospital charges, discharge destination were main outcomes. Results. LOS was 13% longer and hospital charges were 12.5–18.0% higher in the very low Hct than remaining groups (p = 0.0001). The FIM score and subscores for walking, stair climbing, bathing, transfers, and dressing changes were comparable for all Hct groups for the overall score. Hct <30% did not correspond to worse outcomes in patients with bilateral surgeries compared with unilateral surgeries; total FIM scores improved 47–53% across all Hct groups, regardless of bilateral surgical status. Discharge to home ranged 92.6–94.7% across all Hct groups (p > 0.05). Conclusions. Rehabilitation teams can expect comparable functional improvements and discharge to home in anemic and non-anemic patients with either unilateral or bilateral surgeries without hematologic correction in the rehabilitation setting, but might need an additional day to accomplish these outcomes.
Impact de la supplémentation en fer chez des femmes enceintes suivies au centre de Protection maternelle et infantile de Sidi Bel Abbès (Ouest algérien)

En raison de sa frequence, l’anemie due a une carence en fer constitue un probleme majeur de sante publique, elle touche pres de 2,15 milliards de personnes a travers le monde, les femmes enceintes pour l’essentiel mais aussi les adolescents et les nourrissons. Dans cette etude controlee, prospective et longitudinale, nous avons explore chez 83 femmes enceintes, la probable correlation entre les facteurs anthropometriques et l’installation de l’anemie ; nous nous sommes aussi interesses a l’effet de la supplementation en fer sur la modification des parametres hematologiques chez les femmes enceintes anemiques. Apres examen de ces parametres au premier trimestre de grossesse (3 mois ± 2 semaines d’amenorrhee) chez les 83 femmes enceintes, nous avons releve un nombre de 31 femmes presentant une anemie (hemoglobine < 11 g\100 mL), dont 16 presentaient une anemie moderee (7 g\dL Hb < 10 g\dL), 15 une anemie legere (10 g\dL Hb <11 g\dL), alors qu’aucun cas d’anemie severe n’a ete decele dans notre etude. Par ailleurs, nous n’avons releve aucune correlation franche entre l’installation de l’anemie et certains facteurs comme l’âge (r ∓ 0,09), le nombre de grossesses (r ∓ ‐‐ 0,30), l’espace intergenesique (r ∓ 0,03) et le nombre d’avortements (r ∓ ‐‐ 0,18). Cependant, une supplementation en fer de 30 mg\j prescrite a toutes les femmes anemiques (n ∓ 31) pendant une duree de quatre mois, a permis de retablir certains parametres hematologiques. En effet, chez le groupe de femmes supplementees, les taux d’hemoglobine et du fer serique augmentent. Ainsi, une forte correlation positive a ete trouvee entre ces deux parametres (r ∓ 0,89). Par ailleurs, le taux des globules rouges (GR) et la concentration corpusculaire moyenne en hemoglobine (CCMH) augmentent significativement (p < 0,05) chez le groupe de femmes anemiques supplementees. Nous avons note que la prevalence de l’anemie au premier trimestre (avant le debut de la supplementation) etait de 34,1 % au troisieme trimestre et qu’apres supplementation, elle chute a 6,3 %. A l’issue de cette etude, il semblerait que la supplementation en fer previenne la chute de l’hemoglobine et du fer serique qui survient chez le groupe de femmes non anemiques. Nous pensons que la supplementation en fer est une bonne strategie pour traiter et prevenir l’anemie au cours de la grossesse.
Widely linear block-diagonalization type precoding in massive mimo systems with IQ imbalance

In this paper, we propose widely-linear block diagonalization (BD) type precoding techniques to alleviate the impact of IQ imbalance in the downlink Massive multi-input multi-output (MIMO) systems. We first introduce a real-valued signal model and then develop widely-linear BD (WL-BD) type precoding algorithms, i.e., WL-BD, widely linear regularized BD (WL-RBD) and widely linear simplified generalized MMSE channel inversion (WL-S-GMI). We also present analysis of the sum-rate and multiplexing gain achieved by the proposed WLBD for scenarios with and without IQ imbalance. Numerical results verify the analysis and show that WL-BD type precoding methods significantly outperform their conventional counterparts with IQ imbalance and approach the ideal case.
Cancer risk among female nurses: a literature review

Some studies have demonstrated increased risk of different cancers among female nurses. A review of relevant papers was made to assess whether the increase is caused by occupational exposures or other factors. A computerized literature search on combinations of the keywords ‘nurses’, ‘occupation’, ‘hazards’, ‘cancer’ and ‘mortality’ and related articles was performed. A total of 30 reports were identified from 19 independent studies conducted between 1983 and 2001. The majority of the studies were registry studies, with limited data on employment history and confounding factors. In conclusion, knowledge about exposures and observed excesses of cancer risk give reason to suspect an occupational influence on breast cancer and leukaemia. The grouping together of nurses from different workplaces may camouflage real differences in risk. Future studies should collect information at the individual level about work history and personal risk factors.
Vegetation structure of plantain-based agrosystems determines numerical 1 dominance in community of ground-dwelling ants 2 3 4

23 In tropics, ants can represent an important part of animal biomass and are known to be 24 involved in ecosystem services, such as pest regulation. Understanding the mechanisms 25 underlying the structuring of local ant communities is therefore important in agroecology. In 26 the humid tropics of Africa, plantains are cropped in association with many other annual and 27 perennial crops. Such agrosystems differ greatly in vegetation diversity and structure and are 28 well-suited for studying how habitat-related factors affect the ant community. We analysed 29 abundance data for the six numerically dominant ant taxa in 500 subplots located in 20 30 diversified, plantain-based fields. We found that the density of crops with foliage at 31 intermediate and high canopy strata determined the numerical dominance of species. We 32 found no relationship between the numerical dominance of each ant taxon with the crop 33 diversity. Our results indicate that the manipulation of the densities of crops with leaves in the 34 intermediate and high strata may help maintain the coexistence of ant species by providing 35 different habitat patches. Further research in such agrosystems should be performed to assess 36 if the effect of vegetation structure on ant abundance could result in efficient pest regulation. 37
Association of CYP2E1 and NAT2 polymorphisms with lung cancer susceptibility among Mongolian and Han populations in the Inner Mongolian region.

PURPOSE To explore associations of CYP2E1 and NAT2 polymorphisms with lung cancer susceptibility among Mongolian and Han populations in the Inner Mongolian region. MATERIALS AND METHODS CYP2E1 and NAT2 polymorphisms were detected by PCR-RFLP in 930 lung cancer patients and 1000 controls. RESULTS (1) Disequilibrium of the distribution of NAT2 polymorphism was found in lung cancer patients among Han and Mongolian populations (p=0.031). (2) Lung cancer risk was higher in individuals with c1, D allele of CYP2E1 RsaI/PstI, DraI polymorphisms and slow acetylation of NAT2 (c1 compared with c2, OR=1.382, 95%CI: 1.178- 1.587, p=0.003; D compared with C, OR=1.241, 95%CI: 1.053-1.419, P<0.001; slow acetylation compared with rapid acetylation, OR=1.359, 95%CI:1.042-1.768, p=0.056) (3) Compared with c2/c2 and rapid acetylation, c1/c1 together with slow acetylation synergetically increased risk of lung cancer 2.83 fold. (4) Smokers with CYP2E1 c1/c1, DD, and NAT2 slow acetylation have 2.365, 1.916, 1.841 fold lung cancer risk than others with c2/c2, CC and NAT2 rapid acetylation, respectively. (5) Han smokers with NAT2 slow acetylation have 1.974 fold lung cancer risk than others with rapid acetylation. CONCLUSIONS Disequilibrium distribution of NAT2 polymorphism was found in lung cancer patients among Han and Mongolian populations. Besides, Han smokers with NAT2 slow acetylation may have higher lung cancer risk compared with rapid acetylation couterparts. CYP2E1 c1/ c1, DD and NAT2 slow acetylation, especially combined with smoking, contributes to the development of lung cancer. CYP2E1 c1/c1 or DD genotype and NAT2 slow acetylation have strong synergistic action in increasing lung cancer risk.
Role of the Placenta in Preterm Birth: A Review

Abstract Preterm birth is a multifactorial syndrome with a variety of risk factors and long-term health consequences for the child. Placental pathology provides important diagnostic information to ascertain the cause of preterm birth. For example, intra-amniotic infection is one risk factor, but accumulating evidence based on placental pathology, amniotic fluid cultures, and polymerase chain reaction studies suggests infection may be a less common cause of preterm birth than previously suspected, especially after 32 weeks' gestation. Instead, many cases of spontaneous preterm labor leading to preterm birth appear to be caused by placental insufficiency, similar to preeclampsia and fetal growth restriction. Other causes of preterm birth, including retroplacental abruption, chronic villitis, and twin gestations, also have specific placental pathology related to placental insufficiency. New insights into the underlying mechanisms regulating uteroplacental blood flow and the impact of placental malperfusion on placental health may lead to improved early gestation diagnostic testing and a revolution in preventative care for both the mother and her child.
The Dual Process Model of Ideology and Prejudice: A Longitudinal Test During a Global Recession

ABSTRACT This study tested the pathways between personality, social worldviews, and ideology, predicted by the Dual Process Model (DPM) of ideology and prejudice. These paths were tested using a full cross-lagged panel design administered to a New Zealand community sample in early 2008 (before the effects of the global financial crisis reached New Zealand) and again in 2009 (when the crisis was near its peak; n = 247). As hypothesized, low openness to experience predicted residualized change in dangerous worldview, which in turn predicted right-wing authoritarianism (RWA). Low agreeableness predicted competitive worldview, which in turn predicted social dominance orientation (SDO). RWA and SDO also exerted unexpected reciprocal effects on worldviews. This study provides the most comprehensive longitudinal test of the DPM to date, and was conducted during a period of systemic instability when the causal effects predicted by the DPM should be, and were, readily apparent.
Experimental infections with West Nile virus

Purpose of review West Nile virus emerged recently in North America as a serious human and animal pathogen. This review summarizes the use of experimental infections with West Nile virus in diverse vertebrate species that have been used to answer fundamental questions about the host response, pathogenesis of West Nile virus infection and virus evolution. Recent findings West Nile virus has an extremely broad vertebrate host range. Infection of common species of birds has defined those with high vs. low potential to serve as amplifying hosts for the virus. In general, mammals (primates, horses, companion animals) are dead-end hosts for West Nile virus, although some circumstances (i.e. immunosuppression) may allow individuals to become capable of transmitting the virus to mosquitoes. Some mammals (rodents, rabbits, squirrels) and reptiles (alligators) have been found to develop a viremia of sufficient magnitude to predict at least low competence for infecting feeding mosquitoes. Finally, experimental infection of rodents, horses and primates with West Nile virus has been integral to developing and evaluating the efficacy of West Nile virus vaccines. Summary Experimental infection with West Nile virus has assisted in delineating those hosts important and not important to the transmission cycle, in understanding how the virus induces disease in susceptible hosts, and in validating the efficacy of vaccines used for control of disease.
Down‐Regulation of Rac GTPase‐Activating Protein OCRL1 Causes Aberrant Activation of Rac1 in Osteoarthritis Development

Chondrocyte hypertrophy and mineralization are considered to be important pathologic factors in osteoarthritis (OA). We previously reported that Rac1 was aberrantly activated to promote chondrocyte hypertrophy, mineralization, and expression of matrix metalloproteinase 13 and ADAMTS in OA. However, the underlying mechanism of aberrant Rac1 activation in OA is unclear. The present study was undertaken to identify the specific molecular regulator controlling Rac1 activity in OA, as well as to investigate its function in chondrocyte hypertrophy, mineralization, and OA development.
Current decomposition in helical antennas using ESPRIT

To better understand the working principles of the helical antenna, the ESPRIT algorithm is introduced to extract the different current modes on the antenna. The strengths and phase velocities of the current modes are calculated and their effects on the polarization and gain of the antenna are investigated. We found that both the reflected current and their image currents contaminate the circular polarization purity of the antenna. Also it was found that the dominant radiation mechanism on the helical antenna switches from the T0 mode to the T1 mode as the frequency is increased. These physical interpretations are facilitated by an accurate decomposition of the current. Such an approach may be particular useful in gaining insights for designing more complicated helical structures.
Factors Influencing the Spread of Domestic Violence among Heterosexual Marriage in Western Kenya

Domestic violence in heterosexual marriage remains a major rising intimate social challenge with distinct unique features in various family households [1-3]. There is need for integrated appropriate traditional contexts of different values and norms to control and prevent recurrent collision of modern gender equality regime policies [4]. This is in part due to the complex interplay between gender and children relationships in the modern societies of rising tides, gender equality and cultural change [5]. Domestic violence remains a global obstacle , and a family disaster in achievement of sustainable development goals of vision 2030, that need health prevention [6], on ending poverty in all its forms, to end hunger, achieve food security and improved nutrition, and promote sustainable agriculture, to ensure healthy lives and promote well-being for all at all ages, Ensure inclusive and equitable quality education Crimson Publishers Wings to the Research Research Article
Multibody Systems Dynamics : Modelica Implementation and Bond Graph Representation

Using an example of the snakeboard, a vehicle with four wheels and nonholonomic constraints, the process of construction and verification for the sparse dynamical models of the multibody systems is analyzed. Two approaches for the formal representation of the models: object-oriented, and bond graph based are considered. Energy based similarities between these approaches are analyzed. A detailed description of the bond graph representation for the most general type of constraint is presented. It turned out the resulting total bond graph model of the multibody system dynamics always has exactly a canonical junction structure. This representation has a tight correspondence with our recent object-oriented implementation of the mechanical constraint architecture. As an example Modelica implementation of the joint classes family is investigated. Finally these classes are applied to construct the snakeboard dynamic model.
Chronic Diseases, Health Status and Health Service Utilization among Koreans

This study described the self-reported chronic diseases and health status and examined the factors that are associated with effective health service utilization. Descriptive and logistic regression analysis was performed to determine the factors significantly associated with self-rated health, in-patient and out-patient utilization. Self-rated health status was ranked lower among rural residents, lower-income families, married persons, and those with chronic diseases. Chronic diseases such as hypertension, arthritis, melancholy, and diabetes were common and they are associated with poor health of Koreans. The presence of chronic diseases was significant in predicting the likelihood of poor health while socio-economic factors, rather than health-related need factors, had more predictive power of the use of health services. This study provides a unique contribution to the knowledge base of the Korean population. The study findings show that Koreans in poor health status were married, living in rural areas, having chronic diseases and lower income, with a high likelihood of health care utilization among employed individuals, which could significantly help in the public health policy required to address this issue.
Reflections in Hilbert Space II : Szegedy ’ s scheme for Markov chain quantization

The geometric picture developed in previous lecture for Grover’s search can be applied to any pair of projectors. This is the key to most of the quantum speed-ups that are quadratic. Some of these generalization and applications of arbitrary reflection operators were pointed out in [1]. Szegedy published a pair of papers[2, 3] that contained many of the same results, however builds upon previous work by pointing out a correspondence between projection on to subspaces associated with Markov chains. This is the focus of this lecture. Szegedy’s scheme is an important generalization of Grover’s algorithm because it simplifies access to the promised quadratic speed up of quantum computation and, like Grover’s search, employs the product of two reflections for unitary dynamics. The most important technical contribution of Szegedy’s scheme is the spectral decomposition which is covered in the next lecture. The final portion of this lecture is a review of the singular value decomposition used heavily in the spectral decomposition.
STUDY ON COLLAPSE OF FLEXURE-SHEAR-CRITICAL REINFORCED CONCRETE FRAMES

1 PhD Candidate, Dept. of Civil Engineering, University of British Columbia, Vancouver, Canada 2 M.Sc. Candidate, Dept. of Civil Engineering, National Taiwan University, Taipei, Taiwan 3 Associate Professor, Dept. of Civil Engineering, University of British Columbia, Vancouver, Canada 4 Associate Research Fellow, National Center for Research on Earthquake Engineering, Taipei, Taiwan 5 Professor, Dept. of Civil Engineering, National Taiwan University, Taipei, Taiwan 6 Professor, Dept. of Civil and Environmental Engineering, University of California, Berkeley, USA