Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of smoothelin and smooth muscle actin in the skin.

INTRODUCTION Smoothelin is a cytoskeletal protein of differentiated smooth muscle cells with contractile capacity, distinguishing it from other smooth muscle proteins, such as smooth muscle actin (SMA). OBJECTIVE To evaluate the expression of smoothelin and SMA in the skin in order to establish specific localizations of smoothelin in smooth muscle cells with high contractile capacity and in the epithelial component of cutaneous adnexal structures. METHODS Immunohistochemical analysis (smoothelin and SMA) was performed in 18 patients with normal skin. RESULTS SMA was expressed by the vascular structures of superficial, deep, intermediate and adventitial plexuses, whereas smoothelin was specifically expressed in the cytoplasm of smooth muscle cells of the deepest vascular plexus and in no other plexus of the dermis. The hair erector muscle showed intense expression of smoothelin and SMA. Cells with nuclear expression of smoothelin and cytoplasmic expression of SMA were observed in the outer root sheath of the inferior portion of the hair follicles and intense cytoplasmic expression in cells of the dermal sheath to SMA. CONCLUSIONS We report the first study of smoothelin expression in normal skin, which differentiates the superficial vascular plexus from the deep. The deep plexus comprises vessels with high contractile capacity, which is important for understanding dermal hemodynamics in normal skin and pathological processes. We suggest that the function of smoothelin in the outer root sheath may be to enhance the function of SMA, which has been related to mechanical stress. Smoothelin has not been studied in cutaneous pathology; however we believe it may be a marker specific for the diagnosis of leiomyomas and leiomyosarcomas of the skin. Also, smoothelin could differentiate arteriovenous malformations of cavernous hemangioma of the skin.
A WT1 protein‐derived, naturally processed 16‐mer peptide, WT1332, is a promiscuous helper peptide for induction of WT1‐specific Th1‐type CD4+ T cells

The Wilms' tumor gene WT1 is overexpressed in various tumors, and the WT1 protein has been demonstrated to be an attractive target antigen for cancer immunotherapy. A WT1 protein‐derived 16‐mer peptide, WT1332 (KRYFKLSHLQMHSRKH), which was naturally generated through processing in cells and could elicit Th1‐type CD4+ helper T cell responses with an HLA‐DRB1*0405‐restriction has previously been identified by us. In the present study, it has been demonstrated that WT1332 can induce WT1332‐specific CD4+ T cell responses with the restriction of not only HLA‐DRB1*0405 but also HLA‐DRB1*1501, ‐DRB1*1502, or ‐DPB1*0901. These HLA class II‐restricted WT1332‐specific CD4+ T cell lines produced IFN‐γ but neither IL‐4 nor IL‐10 with WT1332 stimulation, thus showing a Th1‐type cytokine profile. Furthermore, HLA‐DRB1*1501 or ‐DRB1*1502‐restricted WT1332‐specific CD4+ T cell lines responded to WT1‐expressing transformed cells in an HLA‐DRB1‐restricted manner, which is consistent with our previous finding that WT1332 is a naturally processed peptide. These results indicate that the natural peptide, WT1332, is a promiscuous WT1‐specific helper epitope. WT1332 is expected to apply to cancer patients with various types of HLA class II as a WT1‐specific helper peptide in combination with HLA class I‐restricted WT1 peptides.
A Cycle-Accurate Simulator for a Reconfigurable Multi-Media System

This paper introduces a cycle-accurate Simulator for a dynamically REconfigurable MUlti-media System, called SimREMUS. SimREMUS can either be used at transaction-level, which allows the modeling and simulation of higher-level hardware and embedded software, or at register transfer level, if the dynamic system behavior is desired to be observed at signal level. Trade-offs among a set of criteria that are frequently used to characterize the design of a reconfigurable computing system, such as granularity, programmability, configurability as well as architecture of processing elements and route modules etc., can be quickly evaluated. Moreover, a complete tool chain for SimREMUS, including compiler and debugger, is developed. SimREMUS could simulate 270k cycles per second for million gates SoC (System-on-a-Chip) and produced one H.264 1080p frame in 15 minutes, which might cost days on VCS (platform: CPU: E5200@ 2.5Ghz, RAM: 2.0GB). Simulation showed that 1080p@30fps of H.264 High Profile@ Level 4 can be achieved when exploiting a 200MHz working frequency on the VLSI architecture of REMUS.
Predictive discomfort of supine humans in whole-body vibration and shock environments

Abstract This work presents a predictive model to evaluate discomfort associated with supine humans during transportation, where whole-body vibration and repeated shock are predominant. The proposed model consists of two parts: (i) static discomfort resulting from body posture, joint limits and ambient discomfort; and (ii) dynamic discomfort resulting from the relative motion between the body segments as a result of transmitted vibration. Twelve supine subjects were exposed to single and 3D random vibrations and 3D shocks mixed with vibrations. The subjects’ reported discomfort and biodynamic response were analysed under different support conditions, including a rigid surface, a stretcher and a stretcher with a spinal backboard. The results demonstrated good correlations between the predictive discomfort and the reported discomfort for the different conditions under consideration, with R2 = 0.69–0.94 for individual subjects and R2 = 0.94 for the group mean. The results also indicated a strong relationship between the head-neck and trunk angular velocities and discomfort during supine transportation. Practitioner Summary: The quantification of discomfort of supine humans under vibration and shocks by using a predictive model is an important contribution to this field, whereby the efficacy of different transport systems can be compared. The predictive discomfort model can be used as design criteria for ergonomic enhancement in supine transportation of humans.
Where's the Kink? Disappointment Events in Consumption Growth and Equilibrium Asset Prices

I propose a consumption-based asset pricing model with disappointment aversion to investigate the link between downside consumption risk and expected returns across asset markets. I find that the disappointment model can explain 95% of the cross-sectional variation in size/book-to-market portfolios and more than 80% of the variation in the joint sample of stocks, bonds, and commodity futures. I also show that the performance of the disappointment model is comparable to that of the Fama-French three-factor specification, regardless of the sample frequency (annual, quarterly). Overall, my results indicate that disappointment aversion considerably improves the fit of consumption-based asset pricing models.Received November 27, 2014; editorial decision September 18, 2016 by Editor Stefan Nagel.
Soft magnetic composites used in the special electric motor magnetic cores

Soft magnetic composites are used in the electrical motors' manufacture and can be considered as magnetic powder particles surrounded by an electrical insulating material. Today there is an interest in bulk soft magnetic composites, because of the high demand for miniaturization of the cores. These materials provide several advantages over classical non-oriented electrical steels. A Somaloy 500 torroidal sample was characterized, using a digital wattmeter. The normal magnetization curve was measured at 3 Hz and the total energy losses, relative magnetic permeability and its components (real and imaginary part) and coercive force were determined as a function of the frequency at the peak magnetic polarization Jp of 100 mT, 250 mT and 500 mT.
Remote interpretation in medical encounters: a systematic review

We conducted a systematic review of remote interpretation. Any published or unpublished research article that had telephone or videoconferenced interpretation as an intervention was included in the review. Nine articles were identified: seven on telephone and two on videoconferenced interpretation. Only one study was a randomized controlled trial. Remote interpretation was associated with shorter intervals between consultations, but there were no consistent differences in relation to consultation length. Client and doctor satisfaction was as good with remote interpretation as with face-to-face interpretation, but interpreters preferred face-to-face interpretation. Although the costs associated with remote interpreting are higher, especially in the case of videoconferencing, these may be offset by efficiency gains. The review suggests that remote interpretation is an acceptable and accurate alternative to traditional methods, although the associated costs are higher.
The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2High receptors

Dopaminergic stabilizers are recognized as compounds that can either enhance or antagonize dopamine (DA)‐dependent behaviors depending on the prevailing dopaminergic tone. The dopaminergic stabilizer ASP2314 is being tested clinically and has been reported to have antipsychotic effects in a clinical trial as an add on medication. To elucidate the mechanisms of action of this dopaminergic stabilizer, its potency on the functional dopamine D2High receptors was examined. In competition with D2 receptors selectively labeled by [3H]domperidone, ASP2314 had a dissociation constant, KiHigh, of 1.62 μM for D2High in human cloned D2Long receptors and 0.83 μM for rat homogenized striata. Using the D2 agonist ligand [3H](+)‐4‐propyl‐3,4,4a,5,6,10b‐hexahydro‐2H‐naphtho[1,2‐b][1,4]oxazin‐9‐ol ((+)PHNO), ASP2314 had a high‐affinity Ki of 32 nM for D2High for rat homogenized striata. ASP2314 stimulated the incorporation of [35S]GTP‐γ‐S into rat striata by 50% at 43 nM, and into the cloned D2Long membranes by 50% at 3.2 μM (compared to 100% stimulation by 10 μM dopamine). With similar concentrations of ASP2314 inhibiting the binding of ligands at D2High and stimulating [35S]GTP‐γ‐S incorporation, the data indicate that the dopaminergic stabilizing action of ASP2314 may be related to the selectivity for the D2high state of the D2 receptor. Synapse 63:930–934, 2009. © 2009 Wiley‐Liss, Inc.
Effectiveness of the IDAP Treatment Program for Male Perpetrators of Intimate Partner Violence

Despite substantial problems with intimate partner violence (IPV) worldwide, the empirical support remains weak for the effectiveness of recidivism-reducing interventions for IPV perpetrators. We conducted a controlled study of the effectiveness of the Integrated Domestic Abuse Program (IDAP), a manual-based group intervention for adult male IPV offenders. A consecutive series of 340 convicted male IPV offenders who began IDAP in the Swedish Prison and Probation Services 2004 to 2007 were compared with 452 contemporary, convicted male IPV offender controls. We obtained follow-up reconviction data from the National Crime Register and used Cox regression to model the effectiveness of IDAP versus regular treatment. Treated and control subjects were all followed until March 2, 2011, for an average time-at-risk of 4.6 years (median 4.4, SD = 1.0). Twenty-five percent (n = 84) of IDAP participants recidivated in any violence versus 23% of controls (n = 104); corresponding figures for IPV specifically were 19% (n = 65) and 19% (n = 84), respectively. Intention-to-treat analyses adjusted for individual baseline risk and follow-up time suggested marginally and non-significantly lower reconviction rates in IDAP participants versus controls (hazard ratio [HR] = 0.92, 95% confidence interval [CI] = [0.69, 1.23] for any violence and HR = 0.92, 95% CI = [0.66, 1.28] for IPV, respectively). Hence, possible recidivism-reducing effects of IDAP in this cross-cultural validation were small and impossible to secure statistically. To remedy the frustrating lack of proven effective treatments for IPV offenders, better interventions should be developed and tested. Such efforts could benefit from improved knowledge about IPV-specific, causal risk factors and more powerful treatment combinations.
Neural substrates for observing and imagining non-object-directed actions

Abstract The present fMRI study was aimed at assessing the cortical areas active when individuals observe non-object-directed actions (mimed, symbolic, and meaningless), and when they imagine performing those same actions. fMRI signal increases in common between action observation and motor imagery were found in the premotor cortex and in a large region of the inferior parietal lobule. While the premotor cortex activation overlapped that previously found during the observation and imagination of object-directed actions, in the parietal lobe the signal increase was not restricted to the intraparietal sulcus region, known to be active during the observation and imagination of object-directed actions, but extended into the supramarginal and angular gyri. When contrasting motor imagery with the observation of non-object-directed actions, signal increases were found in the mesial frontal and cingulate cortices, the supramarginal gyrus, and the inferior frontal gyrus. The opposite contrast showed activation virtually limited to visual areas. In conclusion, the present data define the common circuit for observing and imagining non-object-directed actions. In addition, they show that the representation of non-object-directed actions include parietal regions not found to be involved in coding object-directed actions.
Morphology of the intestinal mucosa and growth performance of chickens fed diets containing sugar cane extract

To investigate the growth performance and small intestinal histological changes in chickens fed sugar cane extract (SCE), 42 layer-type chicks were divided into three groups of 0, 0.05, and 0.10% dietary SCE diets. The growth performance tended to be better in all dietary SCE groups. Intestinal villus height, villus area, cell area and cell mitosis number of the duodenum showed a higher values in all the SCE groups, and the cell area of 0.10% SCE group and cell mitosis of all the SCE groups were higher than the 0% SCE group (P<0.05). After feeding of dietary SCE, protuberated cells and aggregation of protuberated cells were found in the duodenum and jejunum, as well as segmented fi lamentous bacteria appeared in the ileum. These suggest that the dietary SCE might be induce the structural hypertrophy of intestinal villi and epithelial cells on villus tip surface, resulting in the 56% heavier body weight gain in the SCE groups than the control.
Complex organisational integration : a case study of health and social care integration in England

This dissertation aims to provide a strong contribution to the public debate which centres on health and social care integration in England. With ever increasing demands on the health and social care system, politicians have championed the integration between the two sectors as a major element to cope with this challenge. Indeed, verbal opposition to this policy is scarce, yet integration efforts do not tend to be readily observable and wide-spread. Moreover, service redesign efforts cost multiple millions of pounds, therefore, what could be done to improve these processes is critical and pertinent at this time of great challenge for our care services. The main objective of the goal-directed research in this dissertation is to uncover to what extent social psychological processes play a role in this seeming ‘disconnect’ between what people ‘say’ and what they actually ‘do’. To create this insight, a series of five social studies were designed using a mixed research methods approach, using new and interactive technology to capture this data. A total of sixty-three individuals volunteered to participate in the study. The results indicate that comparatively healthcare participants indicate higher levels of social empathy, social perspective taking, and willingness to reach out and share funding with those in social care during the explicit studies. Yet, the implicit data suggest a moderate to strong automatic preference for healthcare over social care by participants from the healthcare sector. The findings in this cast a certain doubt over the use of traditional behavioural analysis techniques such as surveys and interviews. We provide a way forward to increase the validity of these methods and provide recommendations for policy for health and social care integration in England.
Asthma after consumption of snails in house‐dust‐mite‐allergic patients: a case of IgE cross‐reactivity

A group of 28 patients from Italy was studied who had asthma after consumption of snail. All patients also had asthma and/or rhinitis caused by house‐dust mite. RAST analyses confirmed the combined sensitization to snail and mite. In a few sera, IgE antibodies reactive with other foods of invertebrate origin (mussel and shrimp) were detected. RAST inhibition showed that most IgE antibodies against snail were cross‐reactive with house‐dust mite. In contrast, the mite RAST was not significantly inhibited by snail. This indicates that house‐dust mite was the sensitizing agent. Immunoblot analyses revealed multiple bands in snail extract recognized by IgE. In contrast to what has been described for cross‐reactivity between shrimp and mite, tropomyosin played only a minor role as a cross‐reactive allergen in these patients. The observations in this study indicate that snail consumption can cause severe asthmatic symptoms in house‐dust‐mite‐allergic patients. It might, therefore, be advisable to screen mite‐allergic asthma patients for allergy to snail and other invertebrate animal foods.
A Novel Transverse-Flux PM Linear Machine With Double Ω-Hoop Stator

Multifarious topologies of a transverse flux permanent magnet machine (TFPMM) with characteristics of a large torque and considerable pole-number have been proposed. A TFPMM with a double Ω-hoop stator laminated by traditional steel sheets is presented in this study to enhance the performance of space utilization and power density. The construction of this machine stretches far beyond double-sided ones of the space utilization owning to the most occupied space by efficacious materials. The operation principles, parameter calculation, electromagnetic characteristics, and magnetic field analysis by a three-dimensional finite-element method are presented in detail. The power density curve agrees very well with the theoretical analysis, which has an impressive increment due to a high space utilization ratio. Benefited from the novel topology, this machine is suitable for electric propulsion application in urban rail transit systems.
Problematic gambling on dopamine agonists: Not such a rarity

Excessive gambling is recognized with dopamine agonist therapy, but the prevalence is unknown. We assessed the prevalence of excess gambling by specific prospective enquiry in Parkinson's disease patients attending six West Scotland movement disorder clinics. Of 388 patients taking anti‐Parkinson medication, 17 (4.4%) developed pathological gambling, all of whom were prescribed dopamine agonists. Thus, 8% of patients taking dopamine agonists had pathological gambling. Pathological gambling is not uncommon, and patients should be made aware of this potential adverse effect. © 2006 Movement Disorder Society
TP53 gene mutations in canine osteosarcoma.

OBJECTIVE To investigate mutations of the TP53 gene in canine osteosarcoma (OS). STUDY DESIGN Clinical historic cohort study. ANIMALS Client-owned dogs. METHODS OS (n=59) were screened for mutations of the complete TP53 gene using polymerase chain reaction and the mutation was analyzed by single-strand conformational polymorphism. Clinical outcome of dogs with TP53-mutated OS were compared with dogs with OS without a mutation after complete surgical excision of the primary tumor. RESULTS TP53 gene mutations were observed in 24 of 59 (40.7%) OS; 3 mutated OS had 2 mutations. The alterations consisted mainly of point mutations (74%). Dogs with mutated OS had a significantly shorter survival time (ST) after surgery than dogs with normal tumor TP53 gene expression (P=.03). Other significant prognosticators for ST and disease-free interval included elevated serum alkaline phosphatase (P<.01) and tumor grade (P=.01). CONCLUSION TP53 genetic mutations are common in canine OS and may have a prognostic value. CLINICAL RELEVANCE Mutations of the TP53 gene may influence survival and should be considered when evaluating canine OS.
Determinants of the Quality of Primary and Secondary Public Education in West Virginia

Studies analyzing expenditures for public education have used a variety of inputs into the educational process as proxies for the quality of education. This study attempts to isolate some of the inputs which do, in fact, have an effect upon educational quality. To accomplish this, output measures of quality were derived from a sample of 5,000 West Virginia University students who had graduated from high schools within the state. The results show that only one of the input variables examined, teachers' salaries, was significantly related to the output measures of quality. In addition, factors exogenous to the local school system-factors reflecting socioeconomic characteristics of the communities in which the school systems were located-were observed to have a significant effect upon quality. The results give rise to dual conclusions. First, input variables seem to be imprecise measures of educational quality. Second, the empirical evidence provides some support for the contention that the quality of education may be improved by offering higher salaries to teachers.
An Examination of Women’s Sports Coverage on the Twitter Accounts of Local Television Sports Broadcasters

This study examines the amount of coverage given to women’s sports by local television sports broadcasters on Twitter. A total of 19,649 tweets from 201 local sports broadcasters throughout the United States were examined using content analytic methods during a constructed 2-week period. Results demonstrated that while a majority of the local sports broadcasters did tweet about women’s sports, these tweets represented only about 5% of the overall number of messages. Further examination demonstrates that female sports broadcasters tweeted about women’s sports less frequently than male sports broadcasters did. Additionally, broadcasters in smaller cities were more likely to report about women’s sports than those in larger cities. While results are consistent with previous research on gender representation on nationally televised highlight shows, these findings are significant because they demonstrate that there is a relationship between gender of broadcaster and market size in relation to the number of tweets about women’s sports. Additionally, data are from Twitter, in which there are no time constraints that would seemingly limit the amount of women’s sports that could be mentioned by a sportscaster.