Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Barefoot and Shod Running on Limb and Joint Stiffness Characteristics in Recreational Runners

ABSTRACT The authors aimed to determine the effects of barefoot (BF) and several commercially available barefoot-inspired (BFIS) footwear models on limb and joint stiffness characteristics compared with conventional footwear (CF). Fifteen male participants ran over a force platform at 4.0 m.s−1, in BF, BFIS, and CF conditions. Measures of limb and joint stiffness were calculated for each footwear. The results indicate that limb and knee stiffness were greater in BF and minimalist BFIS than in CF. CF and more structured BFIS were associated with a greater ankle stiffness compared with BF and minimalist BFIS. These findings serve to provide further insight into the susceptibility of runners to different injury mechanisms as a function of footwear.
Impact of failed allograft nephrectomy on initial function and graft survival after kidney retransplantation

The management of an asymptomatic failed renal graft remains controversial. The aim of our study was to explore the effect of failed allograft nephrectomy on kidney retransplantation by comparing the outcome of recipients who underwent graft nephrectomy prior to retransplantation with those who did not. Retrospective comparison of patients undergoing kidney retransplantation with (group A, n = 121) and without (group B, n = 45) preliminary nephrectomy was performed, including subgroup analysis with reference to patients with multiple (≥2) retransplantations and patients of the European Senior Program (ESP). Nephrectomy leads to increased panel reactive antibody (PRA) levels prior to retransplantation and is associated with significantly increased rates of primary nonfunction (PNF; P = 0.05) and acute rejection (P = 0.04). Overall graft survival after retransplantation was significantly worse in group A compared with group B (P = 0.03). Among the subgroups especially ESP patients showed a shorter graft survival after previous allograft nephrectomy. On the multivariate analysis, pretransplant graft nephrectomy and PRA >70% were independent and significant risk factors associated with graft loss after kidney retransplantation. Nephrectomy of the failed allograft was not beneficial for retransplant outcome in our series. Patients with failed graft nephrectomy tended to have a higher risk of PNF and acute rejection after retransplantation. The possibility that the graft nephrectomy has a negative impact on graft function and survival after retransplantation is worth studying further.
The Evolution of an Elective in Health Disparities and Advocacy: Description of Instructional Strategies and Program Evaluation.

PROBLEM Health disparities remain pervasive in the United States. Training future physicians to address health disparities requires attention to both systemic and provider causes of disparities, but comprehensive curricula are lacking. APPROACH Albert Einstein College of Medicine in Bronx, New York, offers a 13-session health disparities elective to first-year medical students. The curriculum covers three main content areas: background, provider contributions to health disparities, and systemic contributions to health disparities (i.e., social determinants of health). Teaching methods included didactic and multimedia presentations, reflective discussions, and skill-building seminars (e.g., addressing subconscious assumptions and advocacy training). The authors evaluated the course in 2010-2013 by comparing students' summary scores for knowledge, attitudes, and self-reported confidence on pre- and postintervention tests. They investigated associations between students' sociodemographic characteristics and changes in summary scores. OUTCOMES Scores increased significantly in each domain: Mean knowledge scores increased from 63.6 (± 10.0), out of 100, to 76.4 (± 12.8); mean attitudes scores increased from 16.7 (± 1.9), out of 20, to 18.2 (± 1.1); mean confidence scores increased from 10.7 (± 1.5), out of 16, to 14.4 (± 1.7). Younger students (< 24) had greater changes in confidence than older students. Other sociodemographic characteristics were not associated with changes in any domain. NEXT STEPS Exposure to health disparities instruction is important for medical students. The authors' experience provides insights for incorporating such material into the compulsory curriculum. Future evaluation of outcomes from similar curricula should include measures of clinical behaviors (e.g., through clinical examinations).
Effects of the Central Executive on Postural Control

ABSTRACT The authors focused on individual working memory (WM) capacity and examined its effect on postural control. Participants were 79 young volunteers split into two groups of low- and high WM span, based on scores from the Reading Span Test. The length of unrest was measured in the following conditions: double-leg standing as a single (D-S) task, single-leg standing as a single (S-S) task, double-leg standing as a dual (D-D) task, and single-leg standing as a dual (S-D) task. Regarding inte-group comparisons, total length was prolonged significantly between the low- and the high-span groups but only on the S-D task. The present results revealed that dual-task interference emerged in the low-span group when in a more unstable posture.
Liver transplantation in children using organs from young paediatric donors

Nowadays, most paediatric liver transplant recipients receive a split or other technical variant graft from adult deceased or live donors, because of a lack of available age‐ and size matched paediatric donors. Few data are available, especially for liver grafts obtained from very young children (<6 years). We analysed all paediatric liver transplantations between 1989 and 2009. Recipients were divided into five groups (1–5) depending on donor age (<1, ≥1 to <6, ≥6 to <16, ≥16 to <45, ≥45 years). Overall, 413 paediatric liver transplantations from deceased donors were performed; 1‐ and 5‐year graft survival rates were 75%, 80%, 78%, 81%, 74% and 75%, 64%, 70%, 67%, 46%, and 1‐ and 5‐year patient survival rates were 88%, 91%, 90%, 89%, 78% and 88%, 84%, 84%, 83%, 63% for groups 1–5, respectively, without significant difference. Eight children received organs from donors younger than 1 year and 45 children received organs from donors between 1 and 6 years of age. Overall, vascular complications occurred in 13.2% of patients receiving organs from donors younger than 6 years. Analysis of our data revealed that the usage of liver grafts from donors younger than 6 years is a safe procedure. The outcome was comparable with grafts from older donors with excellent graft and patient survival, even for donors younger than 1 year.
Alternating Adaptation of Eye and Hand Movements to Opposite Directed Double Steps

ABSTRACT Eye and hand movements can adapt to a variety of sensorimotor discordances. Studies on adaptation of movement directions suggest that the oculomotor and the hand motor system access the same adaptive mechanism related to the polarity of a discordance, because concurrent adaptations to opposite directed discordances strongly interfere. The authors scrutinized whether participants adapt their hand and eye movements to opposite directions (clockwise/counterclockwise) when both motor systems are alternatingly exposed to opposite directed double steps, and whether such adaptation is influenced by the allocation of effector to adaptation direction. The results showed that hand and eye movements adapted to opposite directions, but adaptation was biased to the counterclockwise direction. Aftereffects emerged nearly unbiased and independently for both motor systems. The authors conclude that the oculomotor and the hand motor system use independent mechanisms when they adapt to opposite polarities, although they interact during adaptation or concurrent performance.
A survey to determine the views of renal transplant patients on generic substitution in the UK

Rising healthcare costs promote the generic substitution among patients because it is identifiable costs. A key concern is that patients should be involved in the decision of switching. The aim of this study was to examine renal transplant patients’ views on generic substitution in the UK. A total of 163 renal patients were surveyed using 36 multiple‐choice questions at Barts and The London Renal Transplant Clinic, in the UK. Transplant recipients over 18 years, able to read and write English and willing to fill in the questionnaire were targeted; 84% of patients were conscious of the availability of generic medicines, 70% understood the terms “generic” and “branded” in relation to medicines and 54% were aware of generic substitution practice. However, 75% did not know if they were taking generics and 84% felt that generics are not equivalent or only equivalent sometimes and they were uncertain that generics had the same quality as branded medicines. Moreover, many patients admitted that they would not accept the generic substitution of ciclosporin when become available in the UK. A number of factors such as patients’ education, knowledge, severity of the disease, efficacy of generic medicines and patients’ involvement in decisions regarding their health appear to drive patients’ attitudes towards generic substitution.
Impact of Tactile Sensation on Dexterity: A Cross-Sectional Study of Patients With Impaired Hand Function After Stroke

ABSTRACT The authors sought to explore the impact of tactile sensation on manual dexterity and the validity of the strength-dexterity test in subjects with chronic impairments after stroke in a cross-sectional study of 24 patients with impaired hand function after stroke. Dexterity was assessed by the strength-dexterity test, Box and Blocks, and Nine-Hole Peg Test, and the ABILHAND questionnaire. Sensation was measured by pinprick, cotton-wool, graphesthesia, and 2-point discrimination tests. Sensation in the paretic hand had strong association with paretic hand performance in the strength-dexterity test and Nine-Hole Peg Test and explained 13% of the variance. Sensation in the nonparetic hand was associated with the results of the ABILHAND questionnaire. Among sensory tests, 2-point discrimination had the strongest association with dexterity tests. No significant correlations between sensation, pinch force, and dexterity tests were found for the nonparetic hand. The strength-dexterity test exhibited strong correlations with the other dexterity measures and with pinch force. There is an association between tactile sensation and dexterous performance in the paretic hand; activity level performance is associated with sensation in the nonparetic hand. The study supports the validity of the strength-dexterity test when applied in subjects in the chronic stage after stroke.
Renal function and safety in stable kidney transplant recipients converted from immediate‐release to prolonged‐release tacrolimus

This multicenter, open, phase IIIb study assessed short‐term efficacy, safety and dose adjustments in adult stable renal transplant recipients converted from tacrolimus twice‐daily (BID) to once‐daily (QD). Patients receiving unchanged tacrolimus BID for ≥12 weeks were enrolled, and after 6‐weeks, converted from tacrolimus BID to QD (morning dose) on a 1 : 1 (mg : mg) total daily dose basis, for a further 12 weeks. Primary endpoint: change in steady‐state creatinine clearance between treatment phases. Secondary endpoints: biopsy‐proven acute rejection (BPAR), patient and graft survival, safety. 128 patients enrolled (mean age 48.9 years; time post‐transplant 48.9 months); 91 evaluated for the primary endpoint. Mean total daily dose was 0.06 mg/kg (BID) and 0.07 mg/kg (QD); 79.1% required one/no dose changes post‐conversion to maintain recommended blood‐trough levels; average dose increase was small (0.6–0.7 mg/day) with more dose increases in patients on the lowest tacrolimus BID doses. Renal function remained stable and non‐inferiority of tacrolimus QD against tacrolimus BID was demonstrated. There were no BPAR episodes; patient and graft survival were 100%. Adverse events were few; none led to dose modifications/discontinuation. Tacrolimus BID to tacrolimus QD conversion is straightforward and does not compromise renal function in stable kidney transplant patients in the short term.
Spatial Analysis of Handwritten Texts as a Marker of Cognitive Control

ABSTRACT We explore the idea that cognitive demands of the handwriting would influence the degree of automaticity of the handwriting process, which in turn would affect the geometric parameters of texts. We compared the heterogeneity of handwritten texts in tasks with different cognitive demands; the heterogeneity of texts was analyzed with lacunarity, a measure of geometrical invariance. In Experiment 1, we asked participants to perform two tasks that varied in cognitive demands: transcription and exposition about an autobiographical episode. Lacunarity was significantly lower in transcription. In Experiment 2, we compared a veridical and a fictitious version of a personal event. Lacunarity was lower in veridical texts. We contend that differences in lacunarity of handwritten texts reveal the degree of automaticity in handwriting.
Salvaging kidneys with renal allograft compartment syndrome

Renal allograft compartment syndrome is an under recognized cause of early allograft dysfunction which can be reversed by early intervention. It occurs early after renal transplantation where closure of the anterior abdominal wall seems to compress the transplant in the limited retroperitoneal space. The literature about this syndrome in renal transplantation is sparse. Our report describes the diagnostic criteria and the management of two renal transplant recipients with this syndrome. Its diagnosis depends upon duplex vascular scan findings of reversed or absent diastolic flow in the renal vasculature in the absence of any perigraft collection or severe acute tubular necrosis. In our hands emergency laparotomy, decompression of the transplant and closure with interposition mesh salvaged these kidneys.
Raised Creatine Kinase as an Indicator of Inadequate Muscle Debridement in Ballistic Injuries

A male civilian in his forties presented with multiple thoraco-abdominal gunshot wounds (GSW). After resuscitation and surgical repair of intra-abdominal injuries and debridement of wounds, he improved initially and was extubated successfully. However, his creatine kinase (CK) continued to rise post-operatively and this, together with the development of pyrexia on the fifth post-operative day, led to re-exploration of his wounds. At operation he was found to have large areas of dead muscle within the abdominal and chest walls which required extensive resection. In our view the continued rise in CK was a sensitive marker for ongoing muscle death and is useful in this kind of war surgery.
Repercussões maternas e perinatais da ruptura prematura das membranas até a 26ª semana gestacional

PURPOSE: to evaluate maternal and perinatal outcomes of premature rupture of membranes up to the 26th week of gestation. METHODS: retrospective analysis of the cases of premature rupture of membranes up to the 26th week of gestation, without signs of labor or treatment for this condition before admission, followed up at the Obstetric Pathology Infirmary of the "Maternidade Escola Assis Chateaubriand", Federal University of Ceara, from January 1994 to December 1999. The cases with gestational age less than 22 weeks and birth weight lower than 500 g were excluded. Premature rupture of membranes was confirmed by sterile speculum examination. In doubt, amniotic fluid crystallization test and pH determination were performed. All pregnant women underwent ultrasound examination to determine gestational age and amniotic fluid volume. Data concerning the result of gestation and consequences for the mother, fetus and neonate were analyzed. RESULTS: a total of 29 cases of premature rupture of membranes fulfilled inclusion criteria. The mean gestational age at rupture of membranes was 22 weeks. The mean duration of the latency period was 21.7 days. There Were 22 spontaneous vaginal and 3 induced deliveries, besides 4 cesarean sections. In six pregnant women there were signs of infection before labor. Antibiotics were administered in 37.9% of the cases and corticosteroids in 6.9%. No patient underwent tocolysis. There were 3 fetal and 25 neonatal deaths. Only one infant survived. This child remained at the neonatal care unit for 19 days due to infection and respiratory distress syndrome. There was no maternal death. CONCLUSION: the premature rupture of membranes up to the 26th week of gestation has been a fatal discase for fetuses and newborns in our institution.
Psychophysiological Reactions to the Response Phase of the Rorschach and 16PF

In this pilot study, we investigated whether there was a differential psychophysiological response during the beginning, middle, and end of the administration of a performance-based instrument (Rorschach Inkblot Method, RIM; Exner, 2003) versus a self-report measure of personality (Sixteen Personality Factor Questionnaire, 5th ed. [16PF]; Cattell, Cattell, & Cattell, 1993). Results indicate that adult participants (n = 15) experienced greater electrodermal activity during the administration of the RIM as compared to the 16PF. Effect sizes for the differences between the instruments were all very large (Cohen's d = 1.71 at beginning, d = 1.1 at middle, and d = .98 at end).
A theoretical approach to the unification of informetric models by wave-heat equations

A simple distribution function f(x, t)=p(x+q)−βeαt obeys wave and heat equations, that constructs a theoretical approach to the unification of informetric models, with which we can unify all informetric laws. While its space-type distributions deduce naturally Lotka-type laws in size approaches and Zipf-type laws in rank approaches, its time-type distributions introduce the mechanism of Price-type and Brookes-type laws. © 2011 Wiley Periodicals, Inc.
The Use of Social Media in Graduate Medical Education: A Systematic Review

Purpose Despite the growing presence of social media in graduate medical education (GME), few studies have attempted to characterize their effect on residents and their training. The authors conducted a systematic review of the peer-reviewed literature to understand the effect of social media on resident (1) education, (2) recruitment, and (3) professionalism. Method The authors identified English-language peer-reviewed articles published through November 2015 using Medline, Embase, Cochrane, PubMed, Scopus, and ERIC. They extracted and synthesized data from articles that met inclusion criteria. They assessed study quality for quantitative and qualitative studies through, respectively, the Medical Education Research Study Quality Instrument and the Consolidated Criteria for Reporting Qualitative Studies. Results Twenty-nine studies met inclusion criteria. Thirteen (44.8%) pertained to residency education. Twitter, podcasts, and blogs were frequently used to engage learners and enhance education. YouTube and wikis were more commonly used to teach technical skills and promote self-efficacy. Six studies (20.7%) pertained to the recruitment process; these suggest that GME programs are transitioning information to social media to attract applicants. Ten studies (34.5%) pertained to resident professionalism. Most were exploratory, highlighting patient and resident privacy, particularly with respect to Facebook. Four of these studies surveyed residents about their social network behavior with respect to their patients, while the rest explored how program directors use it to monitor residents’ unprofessional online behavior. Conclusions The effect of social media platforms on residency education, recruitment, and professionalism is mixed, and the quality of existing studies is modest at best.
The Predictive Validity of a Text-Based Situational Judgment Test in Undergraduate Medical and Dental School Admissions.

PROBLEM Situational judgment tests (SJTs) can be used to assess the nonacademic attributes necessary for medical and dental trainees to become successful practitioners. Evidence for SJTs' predictive validity, however, relates predominantly to selection in postgraduate settings or using video-based SJTs at the undergraduate level; it may not be directly transferable to text-based SJTs in undergraduate medical and dental school selection. This preliminary study aimed to address these gaps by assessing the validity of the UK Clinical Aptitude Test (UKCAT) text-based SJT. APPROACH Study participants were 218 first-year medical and dental students from four UK undergraduate schools who completed the first UKCAT text-based SJT in 2013. Outcome measures were educational supervisor ratings of in-role performance in problem-based learning tutorial sessions-mean rating across the three domains measured by the SJT (integrity, perspective taking, and team involvement) and an overall judgment of performance-collected in 2015. OUTCOMES There were significant correlations between SJT scores and both mean supervisor ratings (uncorrected r = 0.24, P < .001; corrected r = 0.34) and overall judgments (uncorrected rs = 0.16, P < .05; corrected rs = 0.20). SJT scores predicted 6% of variance in mean supervisor ratings across the three nonacademic domains. NEXT STEPS The results provide evidence that a well-designed text-based SJT can be appropriately integrated, and add value to, the selection process for undergraduate medical and dental school. More evidence is needed regarding the longitudinal predictive validity of SJTs throughout medical and dental training pathways, with appropriate outcome criteria.
Psychometric Properties and Clinical Cut-Off Scores of the Spanish Version of the Social Anxiety Scale for Adolescents

This study examined the reliability and validity evidence drawn from the scores of the Spanish version of the Slovenian-developed Social Anxiety Scale for Adolescents (SASA; Puklek, 1997; Puklek & Vidmar, 2000) using a community sample (Study 1) and a clinical sample (Study 2). Confirmatory factor analysis in Study 1 replicated the 2-factor structure found by the original authors in a sample of Slovenian adolescents. Test–retest reliability was adequate. Furthermore, the SASA correlated significantly with other social anxiety scales, supporting concurrent validity evidence in Spanish adolescents. The results of Study 2 confirmed the correlations between the SASA and other social anxiety measures in a clinical sample. In addition, findings revealed that the SASA can effectively discriminate between adolescents with a clinical diagnosis of social anxiety disorder (SAD) and those without this disorder. Finally, cut-off scores for the SASA are provided for Spanish adolescents.