Miracle-dz/UniFAR-FTUs huggingface dataset:
Field-dependent conductivity and space charge behavior of silicone rubber/SiC composites

High temperature vulcanized (HTV) silicone rubber (SiR), due to its excellent electrical insulation, elasticity and temperature resistance, is used in cable accessories for HVDC cables. The space charge, generated under dc stress in SiR, would distort the local electric field, further influencing the characteristics of partial discharge and accelerating the insulation aging. This paper tried to modify the space charge behaviors of HTV SiR composites by incorporating silicon carbide (SiC) particles into the polymer matrix with the filler content of 10, 30, 50, 100 wt%. The effects of the SiC particle content on the field-dependent conductivity and the space charge behaviors of HTV SiR were studied. The conductivities under different electric fields were measured by a three-electrode system at room temperature and the space charge behaviors were observed by the pulsed electro-acoustic (PEA) method. The results indicated that the conductivity of SiR/SiC composites was a nonlinear function of electric field when the content exceeds 30 wt%. With the increase of filler content, the threshold field for nonlinear conductivity decreased and the nonlinear coefficient increased. Meanwhile, the amount of space charges was dramatically reduced. It is suggested that the SiR/SiC composites with nonlinear conductivity can improve the dc conductivity under high electric field, thus raising the carrier mobility and suppressing the accumulation of space charge.
Neural basis for motor learning in the vestibuloocular reflex of primates. III. Computational and behavioral analysis of the sites of learning.

1. We have used a combination of eye movement recordings and computer modeling to study long-term adaptive modification (motor learning) in the vestibuloocular reflex (VOR). The eye movement recordings place constraints on possible sites for motor learning. The computer model abides by these constraints, as well as constraints provided by data in previous papers, to formalize a new hypothesis about the sites of motor learning. The model was designed to reproduce as much of the existing neural and behavioral data as possible. 2. Motor learning was induced in monkeys by fitting them with spectacles that caused the gain of the VOR (eye speed divided by head speed) to increase to values > 1.6 or to decrease to values < 0.4. We elicited pursuit by providing ramp motion of a small target at 30 degrees/s along the horizontal axis. Changes in the gain of the VOR caused only small and inconsistent changes in the eye acceleration in the first 100 ms after the onset of pursuit and had no effect on the eye velocity during tracking of steady target motion. Electrical stimulation in the flocculus and ventral paraflocculus with single pulses or trains of pulses caused smooth eye movement toward the side of stimulation after latencies of 9-11 ms. Neither the latency, the peak eye velocity, nor the initial eye acceleration varied as a consistent function of the gain of the VOR. 3. The computer model contained nodes that represented position-vestibular-pause cells (PVP-cells) and flocculus target neurons (FTNs) in the vestibular nucleus, and horizontal gaze-velocity Purkinje cells (HGVP-cells) in the cerebellar flocculus and ventral paraflocculus. Node FTN represented only the "E-c FTNs," which show increased firing for eye motion away from the side of recording. The transfer functions in the model included dynamic elements (filters) as well as static elements (summing junctions, gain elements, and time delays). Except for the transfer functions that converted visual motion inputs into commands for smooth eye movement, the model was linear. 4. The performance of the model was determined both by computer simulation and, for the VOR in the dark, by analytic solution of linear equations. For simulation, we adjusted the parameters by hand to match the output of the model to the eye velocity of monkeys and to match the activity of the relevant nodes in the model to the firing of HGVP-cells, FTNs, and PVP-cells when the gain of the VOR was 0.4, 1.0, and 1.6. (ABSTRACT TRUNCATED AT 400 WORDS)
Novel p53 mutation in a malignant tumor secreting vasoactive intestinal peptide.

OBJECTIVE To assess involvement of p53 mutations in development of pancreatic endocrine tumors. DESIGN Survey of sporadic pancreatic endocrine tumors. SETTING Hospital referral centers, mainly in the Los Angeles, Calif, area. PATIENTS We obtained fresh surgical specimens from 25 patients (convenience sample) with no family history of endocrine tumors and no evidence of multiple endocrine neoplasia 1 or von Hippel-Lindau disease. Preoperative tests included serum peptide analysis. MAIN OUTCOME MEASURES DNA was prepared from tumor specimens. We screened exons 5 through 8 of the p53 gene using single-strand conformation polymorphism analysis, followed by DNA sequencing when a variant was detected. RESULTS A three-base deletion mutation (codon 239) was found in one malignant tumor secreting vasoactive intestinal peptide. CONCLUSIONS p53 appears to have a limited role in development of pancreatic endocrine tumors. However, evidence from one of our patients suggests it may be involved in tumor progression in uncommon cases.
Interaction of pertussis toxin with human T lymphocytes

The binding of pertussis toxin (PT) to the human T-cell line Jurkat was examined by using flow cytometry. Fluorescein isothiocyanate (FITC)-labeled PT bound rapidly to the cells in a specific manner as determined by blocking experiments with unlabeled toxin, B oligomer, and the S2-S4 and S3-S4 dimers. Monoclonal antibodies against the S3 subunit of the toxin also significantly inhibited the binding of FITC-PT. Sialidase treatment of the cells resulted in decreased binding of FITC-PT, indicating that sialic acid residues are involved in the binding process. In addition, we studied the effect of PT binding on the expression of cell surface molecules. On binding of PT to the cell surface, a rapid down-regulation of the T-cell receptor (TCR)-CD3 complex was observed. The modulation of the TCR-CD3 complex was independent of the toxin's enzymatic activity, as the B oligomer and a nonenzymatic toxin mutant induced modulation comparable to that caused by the native holotoxin. Isolated dimers did not cause down-regulation. Stimulation of the TCR-CD3 complex, leading to reduced cell surface expression of this complex, provides a possible explanation for the second messenger production associated with the interaction of PT or B oligomer with T lymphocytes. We therefore conclude that PT activates T cells by divalent binding to the TCR-CD3 complex itself or by binding a structure closely associated with it.
The Detrimental Effect of Poor Early Graft Function After Laparoscopic Live Donor Nephrectomy on Graft Outcomes

We undertook this study to assess the rate of poor early graft function (EGF) after laparoscopic live donor nephrectomy (lapNx) and to determine whether poor EGF is associated with diminished long‐term graft survival. The study population consisted of 946 consecutive lapNx donors/recipient pairs at our center. Poor EGF was defined as receiving hemodialysis on postoperative day (POD) 1 through POD 7 (delayed graft function [DGF]) or serum creatinine ≥ 3.0 mg/dL at POD 5 without need for hemodialysis (slow graft function [SGF]). The incidence of poor EGF was 16.3% (DGF 5.8%, SGF 10.5%), and it was stable in chronologic tertiles. Poor EGF was independently associated with worse death‐censored graft survival (adjusted hazard ratio (HR) 2.15, 95% confidence interval (CI) 1.34–3.47, p = 0.001), worse overall graft survival (HR 1.62, 95% CI 1.10–2.37, p = 0.014), worse acute rejection‐free survival (HR 2.75, 95% CI 1.92–3.94, p < 0.001) and worse 1‐year renal function (p = 0.002). Even SGF independently predicted worse renal allograft survival (HR 2.54, 95% CI 1.44–4.44, p = 0.001). Risk factors for poor DGF included advanced donor age, high recipient BMI, sirolimus use and prolonged warm ischemia time. In conclusion, poor EGF following lapNx has a deleterious effect on long‐term graft function and survival.
User-Independent Recognition of Sports Activities From a Single Wrist-Worn Accelerometer: A Template-Matching-Based Approach

Goal: To investigate the accuracy of template matching for classifying sports activities using the acceleration signal recorded with a wearable sensor. Methods: A population of 29 normal weight and 19 overweight subjects was recruited to perform eight common sports activities, while body movement was measured using a triaxial accelerometer placed at the wrist. User- and axis-independent acceleration signal templates were automatically extracted to represent each activity category and recognize activity types. Five different similarity measures between example signals and templates were compared: Euclidean distance, dynamic time warping (DTW), derivative DTW, correlation and an innovative index, and combining distance and correlation metrics (Rce). Template-based activity recognition was compared to statistical-learning classifiers, such as Naive Bayes, decision tree, logistic regression (LR), and artificial neural network (ANN) trained using time- and frequency-domain signal features. Each algorithm was tested on data from a holdout group of 15 normal weight and 19 overweight subjects. Results: The Rce index outperformed other template-matching metrics by achieving recognition rate above 80% for the majority of the activities. Template matching showed robust classification accuracy when tested on unseen data and in case of limited training examples. LR and ANN achieved the highest overall recognition accuracy ~85% but showed to be more vulnerable to misclassification error than template matching on overweight subjects' data. Conclusion: Template matching can be used to classify sports activities using the wrist acceleration signal. Significance: Automatically extracted template prototypes from the acceleration signal may be used to enhance accuracy and generalization properties of statistical-learning classifiers.
Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine Among Children Aged 6–18 Years with Immunocompromising Conditions: Recommendations of the Advisory Committee on Immunization Practices (ACIP)

On February 20, 2013, the Advisory Committee on Immunization Practices (ACIP) recommended routine use of 13-valent pneumococcal conjugate vaccine (PCV13; Prevnar 13, Wyeth Pharmaceuticals, Inc., a subsidiary of Pfizer, Inc.) for children aged 6-18 years with immunocompromising conditions, functional or anatomic asplenia, cerebrospinal fluid (CSF) leaks, or cochlear implants who have not previously received PCV13. PCV13 should be administered to these children regardless of whether they received the 7-valent pneumococcal conjugate vaccine (PCV7) or the 23-valent pneumococcal polysaccharide vaccine (PPSV23). Recommendations for PPSV23 use for children in this age group remain unchanged. The evidence for the benefits and risks associated with PCV13 vaccination of children with immunocompromising conditions was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) framework. This recommendation reflects a policy change from permissive and off-label recommendation of PCV13 in the pediatric immunocompromised population to a category A recommendation. This report summarizes the evidence considered by ACIP to make this recommendation and reviews the recommendations for use of PCV13 and PPSV23 for children aged 6-18 years.
Insights into the Microbial Degradation of Rubber and Gutta-Percha by Analysis of the Complete Genome of Nocardia nova SH22a

ABSTRACT The complete genome sequence of Nocardia nova SH22a was determined in light of the remarkable ability of rubber and gutta-percha (GP) degradation of this strain. The genome consists of a circular chromosome of 8,348,532 bp with a G+C content of 67.77% and 7,583 predicted protein-encoding genes. Functions were assigned to 72.45% of the coding sequences. Among them, a large number of genes probably involved in the metabolism of xenobiotics and hardly degradable compounds, as well as genes that participate in the synthesis of polyketide- and/or nonribosomal peptide-type secondary metabolites, were detected. Based on in silico analyses and experimental studies, such as transposon mutagenesis and directed gene deletion studies, the pathways of rubber and GP degradation were proposed and the relationship between both pathways was unraveled. The genes involved include, inter alia, genes participating in cell envelope synthesis (long-chain-fatty-acid–AMP ligase and arabinofuranosyltransferase), β-oxidation (α-methylacyl-coenzyme A [α-methylacyl-CoA] racemase), propionate catabolism (acyl-CoA carboxylase), gluconeogenesis (phosphoenolpyruvate carboxykinase), and transmembrane substrate uptake (Mce [mammalian cell entry] transporter). This study not only improves our insights into the mechanism of microbial degradation of rubber and GP but also expands our knowledge of the genus Nocardia regarding metabolic diversity.
The cost–effectiveness of diagnostic cardiac imaging for stable coronary artery disease

Early and accurate diagnosis of stable coronary artery disease (CAD) is crucial to reduce morbidity, mortality and healthcare costs. This critical appraisal of health-economic literature concerning non-invasive diagnostic cardiac imaging aims to summarize current approaches to economic evaluation of diagnostic cardiac imaging and associated procedural risks, inform cardiologists how to use economic analyses for decision-making, highlight areas where new information could strengthen the economic evaluation and shed light on cost-effective approaches to diagnose stable CAD. Economic analysis can support cardiologists’ decision-making. Current economic evidence in the field does not provide sufficient information to guide the choice among different imaging modalities or strategies for each patient. Available economic analyses suggest that computed tomography coronary angiography (CTCA) is a cost-effective approach to rule out CAD prior to invasive coronary angiography in patients with low to intermediate pre-test probability of disease and that stress imaging modalities may be cost-effective at variable pre-test probabilities.
Cleaning up the air: effectiveness of air quality policy for SO 2 and NO x emissions in China

Abstract. Air quality observations by satellite instruments are global and have a regular temporal resolution, which makes them very useful in studying long-term trends in atmospheric species. To monitor air quality trends in China for the period 2005–2015, we derive SO2 columns and NOx emissions on a provincial level with improved accuracy. To put these trends into perspective they are compared with public data on energy consumption and the environmental policies of China. We distinguish the effect of air quality regulations from economic growth by comparing them relatively to fossil fuel consumption. Pollutant levels, per unit of fossil fuel, are used to assess the effectiveness of air quality regulations. We note that the desulfurization regulations enforced in 2005–2006 only had a significant effect in the years 2008–2009, when a much stricter control of the actual use of the installations began. For national NOx emissions a distinct decreasing trend is only visible from 2012 onwards, but the emission peak year differs from province to province. Unlike SO2, emissions of NOx are highly related to traffic. Furthermore, regulations for NOx emissions are partly decided on a provincial level. The last 3 years show a reduction both in SO2 and NOx emissions per fossil fuel unit, since the authorities have implemented several new environmental regulations. Despite an increasing fossil fuel consumption and a growing transport sector, the effects of air quality policy in China are clearly visible. Without the air quality regulations the concentration of SO2 would be about 2.5 times higher and the NO2 concentrations would be at least 25 % higher than they are today in China.
Organizational capabilities that enable big data and predictive analytics diffusion and organizational performance

Purpose Big data and predictive analytics (BDPA) has received great attention in terms of its role in making business decisions. However, current knowledge on BDPA regarding how it might link organizational capabilities and organizational performance (OP) remains unclear. Drawing from the resource-based view, the purpose of this paper is to propose a model to examine how information technology (IT) deployment (i.e. strategic IT flexibility, business–BDPA partnership and business–BDPA alignment) and HR capabilities affect OP through BDPA. Design/methodology/approach To test the proposed hypotheses, structural equation modeling is applied on survey data collected from 159 Indian firms. Findings The results show that BDPA diffusion mediates the influence of IT deployment and HR capabilities on OP. In addition, there is a direct effect of IT deployment and HR capabilities on BDPA diffusion, which also has a direct relationship with OP. Originality/value Through this study, authors demonstrate that IT deployment and HR capabilities have an indirect impact on OP through BDPA diffusion.
Advancing global flood hazard simulations by improving comparability, benchmarking, and integration of global flood models

In recent years, a range of global flood models (GFMs) were developed, each utilizing different process descriptions as well as validation data sets and methods. To quantify the magnitude of these differences, studies assessed the performance of GFMs only on the continental and catchment level. Since the default model set-ups resulted in locally marked deviations, there is a clear need for further and especially more standardized research to not only maintain credibility, but also support the application of GFM products by end-users. Consequently, here we conceptually outline the basic requirements and challenges of a Global Flood Model Validation Framework for more standardized model validation and benchmarking. With the proposed framework we hope to encourage the much needed debate, research developments in this direction, and involvement of science with end-users. By means of the framework, it is possible to streamline the data sets used for input and validation as well as the validation approach itself. By subjecting GFMs to more thorough and standardized methods, we think their quality as well as acceptance will increase as a result, especially amongst end-users of their outputs. Otherwise GFMs may only serve a purely scientific purpose of continued ‘siloed’ model improvement but without practical use. Furthermore, we want to invite GFM developers to make their models more integratable which would allow for representation of more physical processes and even more detailed comparison on a model component basis. We think this is pivotal to not only improve the accuracy of model input data sets, but to focus on the core of each model, the process descriptions. Only if we know more about why GFMs deviate, are we able to improve them accordingly and develop a next generation of models, not only providing first-order estimates of flood extent but supporting the global disaster risk reduction community with more accurate and actionable information.
Hyoid movement during swallowing in older patients with dysphagia.

OBJECTIVES To describe the timing, coordination, and extent of hyoid movement in a population of older adults with dysphagia and to evaluate the effect of hyoid movement on upper esophageal sphincter opening. DESIGN A retrospective review of dynamic swallow studies performed between January 1996 and December 1999 was done. SUBJECTS Patients included in the study were 65 years or older, without an obvious medical or surgical cause for their dysphagia. Timing and distance measures of hyoid movement from the patient population were compared with those from 60 younger (range, 18-62 years) and 23 older (range 67-83 years) control subjects without dysphagia using 1-way analysis of variance. Analysis of the effect of hyoid movement on upper esophageal sphincter opening was performed using contingency tables. RESULTS In an older population with dysphagia, the coordination of swallowing gestures and bolus timing was intact, hyoid elevation was slow, and the duration of maximal hyoid elevation was reduced, but appropriate for the age of the patients. The hyoid bone elevated farther than normal for small bolus sizes, but the patients were unable to maintain this strategy in larger bolus swallows. CONCLUSION An increased extent of hyoid displacement in older patients with dysphagia may represent a necessary compensation designed to minimize the effect of the short duration of hyoid elevation on the upper esophageal sphincter opening.
Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood

Osteosarcoma is the most frequent second primary cancer occurring during the first 20 years following treatment for a solid cancer in childhood. Using a cohort study of children treated for a solid cancer, we investigated the incidence and etiology of osteosarcoma as a second malignant neoplasm after childhood cancer in a cohort and a case‐control study. We analysed the relationship between the local dose of radiation and the risk of osteosarcoma, taking into account chemotherapy received. A cohort study of 4,400 3‐year survivors of a first solid cancer during childhood diagnosed in France or the United Kingdom, between 1942 and 1986, revealed 32 subsequent osteosarcomas. In a nested case‐control study, we matched 32 cases and 160 controls for sex, type of first cancer, age at first cancer and the duration of follow‐up. Parameters studied were the incidence of osteosarcoma, the cumulative local dose of irradiation and the cumulative dose of chemotherapy received by cases and controls. The risk of a osteosarcoma was found to be a linear function of the local dose of radiation (excess relative risk per gray = 1.8), and was found to increase with the number of moles of electrophilic agents per square meter but not with other drugs. No interaction was noted between radiotherapy and chemotherapy. Bilateral retinoblastoma, Ewing's sarcoma and soft tissue sarcoma were found to render patients susceptible to a higher risk of developing an osteosarcoma as a second malignant neoplasm. We recommend long‐term surveillance of patients who were treated during childhood for bilateral retinoblastoma, Ewing's sarcoma, soft tissue sarcoma, as well as other first cancer treated with radiotherapy plus high doses of chemotherapy, without focusing exclusively on the radiation field. Int. J. Cancer 77:370–377, 1998. © 1998 Wiley‐Liss, Inc.