Miracle-dz/UniFAR-FTUs huggingface dataset:
Emergence of cercariae of Echinostoma trivolvis from Helisoma trivolvis under different conditions.

Release of Echinostoma trivolvis cercariae from naturally infected Helisoma trivolvis snails maintained under different laboratory conditions was studied. Infected snails were isolated for 1 hr in Stender dishes containing 5 ml of artificial spring water and the number of cercariae released during this time was recorded. Of the conditions tested, i.e., light versus dark, day versus night, volume of water, snail maintenance temperature prior to isolation, temperature during isolation, food versus no food, aeration of water, disturbance of water, and isolation in snail conditioned water, the only significant factors in the emergence of E. trivolvis cercariae were temperature related. Observations on cercariae released in vitro from isolated rediae maintained in Locke's solutions were in accord with the in vivo results.
Voluntary Disclosure vs. Mandatory Disclosure: The Case of IFRS Introduction on European Firms

The purpose of this study is to determine if the process of filtering out the financial information voluntary disclosed by firms is modified by the introduction of new mandatory information requirement. Voluntary information disclosed by French firms during the 2003-2008 period is compiled. This original dataset includes several years both before and after the introduction of the IFRS in the European Union in 2005. We use regression analysis to identify the determinants and consequences of the communications policies of listed firms. Particularly, we show that highly communicative firms may reduce the information asymmetry as measured by the dispersion of analysts’ earnings forecasts when they voluntarily disclose information. The level of voluntary disclosure and earnings forecasts by analysts are endogenous and exhibit a complex two-way relationship. Voluntary communication policies did not change with the introduction of the IFRS.
Major limitations in knowledge of physical activity guidelines among UK medical students revealed: implications for the undergraduate medical curriculum

Background Education of health professionals is a key element of the wider strategy to increase society's physical activity levels. To date, no study has directly assessed UK medical students’ knowledge of physical activity guidelines or their ability/willingness to prescribe exercise. Methods A questionnaire survey of final year medical students in Scottish Universities was conducted prior to a presentation on the current UK guidelines. Results Completed questionnaires (n=177) represented 37% of the final year cohorts. Physical inactivity was incorrectly perceived to be the least important risk factor to global mortality. 40% stated they were aware of current guidelines, but in a forced choice, 68% were able to correctly identify them for adults. In comparison, 97% correctly identified the UK's alcohol guidelines. 52% stated they felt adequately trained to give physical activity advice to the general public. Conclusions The medical students in this study underestimated the risk of physical inactivity, and did not know the physical activity guidelines as well as other health promotion guidelines. A large proportion remained unconfident about giving physical activity advice. Improved education of this group is required.
TENS relieves acute posttraumatic hip pain during emergency transport.

BACKGROUND In Central Europe, ambulances for patients suffering from pain caused by nonlife-threatening trauma, such as hip fractures are staffed by medical personnel (medics) without physicians. Thus, there is an urgent need for nonpharmacological interventions that can be applied during the transport by basic life-support (BLS) medical personnel. METHODS In all, 101 patients were screened for participation in this randomized placebo-controlled double-blind study, and randomly assigned to two groups (verum and sham transcutaneous electrical nerve stimulation [TENS]). First, medic A recorded all baseline parameters and measurements, then medic B performed TENS in absence of medic A. At the end of transportation, medic A performed data collection. Each patient was asked to grade his/her pain and anxiety level on visual analog scales (VAS, 0 to 100 mm). RESULTS From 101 screened patients fulfilling the entry criteria, 29 declined consent and 9 had to be excluded from the analysis because of their final diagnosis. Therefore, the data from 30 patients (group 1, verum TENS) as well as from 33 patients (group 2 [control], sham TENS) were analyzed. No significant differences in potentially influencing factors were found before treatment. Pain scores upon arrival at the hospital differed significantly between group 1 and group 2 (p < 0.01). In group 1, pain reduction was observed between departure from the site of emergency and arrival at the hospital (VAS: 89 +/- 9 to 59 +/- 6 mm), whereas pain scores remained nearly unchanged in group 2 (VAS: 86 +/- 12 to 79 +/- 11 mm). CONCLUSION Our findings show that TENS is a valuable and fast-acting pain treatment under the difficult circumstances of "out-of-hospital rescue". Because of its lack of side effects, it could also be a valuable tool in the hospital.
Purified Tat induces inflammatory response genes in Kaposi's sarcoma cells

Objective:Kaposi's sarcoma (KS) is a neoplasm strongly associated with HIV-1 infection and marked by leukocytic infiltration. The infiltrating leukocytes are a possible source of inflammatory cytokines, human herpesvirus 8 (HHV8) and the HIV-1 transactivator protein Tat. This study examines whether Tat directly induces expression of cellular adhesion molecules and cytokines in KS cells and whether this induction differs in kinetics and magnitude from induction by tumour necrosis factor (TNF) α. Design and method:Changes in gene expression in response to recombinant Tat compared with those to TNFα were evaluated at the messenger (m) RNA and protein level using cells that were cultured from KS lesions. Results:Tat induced the expression of the adhesion molecules vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) and the cytokines monocyte chemoattractant protein 1 (MCP-1) and interleukin 6 (IL-6). The inductions were observed at both the protein and mRNA levels. The pattern of mRNA induction over time in response to Tat differed from that to TNFα, with higher peak levels that occurred earlier in response to Tat. The expression of these genes is, in part, regulated by the transcription factor NF-κB. Tat and TNFα activated comparable levels of NF-κB. Conclusions:The ability of the HIV-1 Tat to induce the expression of genes with kinetics that are distinct from those seen in TNFα induction suggests that mechanisms in addition to activation of NF-κB contribute to the observed induction. Tat may contribute to the pathogenesis of AIDS-related KS through induction of cellular genes that are pro-proliferative and proinflammatory and may enhance the recruitment of leukocytes, which are a possible source of further cytokines, Tat and HHV8.
On the Pricing of Contingent Capital Notes

A bank's stock price is modeled as a call option on the spread of random assets over random liabilities. The logarithm of assets and liabilities are jointly modeled as driven by four variance gamma processes and this model is estimated by calibrating to quoted equity options seen as compound spread options. On defining risk-weighted assets as asset value less the bid price plus the ask price of liabilities less the liability value we endogenize capital adequacy ratios following the methods of conic finance for the bid and ask prices. All computations are illustrated on CSGN.VX, ADRed into USD on March 29, 2011.
Cingulate function in depression: a potential predictor of treatment response

THE relationship between pretreatment regional cerebral glucose metabolism and eventual antidepressant drug response was measured using positron emission tomography (PET) in hospitalized patients with unipolar depression. Rostral anterior cingulate metabolism uniquely differentiated eventual treatment responders from non-responders. Hypometabolism characterized non-responders when compared with controls, in contrast to responders who were hypermetabolic. Metabolism in no other region discriminated the two groups, nor did associated demographic, clinical or behavioral measures, including motor speed, cognitive performance, depression severity or illness chronicity. Cingulate hypermetabolism may represent an important adaptive response to depression and failure of this response may underlie poor outcome. A critical role for rostral cingulate area 24a/b in the limbic-cortical network involved in abnormal mood states is proposed.
Ankle Joint Mobilization Affects Postoperative Pain Through Peripheral and Central Adenosine A1 Receptors

Background Physical therapists frequently use joint mobilization therapy techniques to treat people with musculoskeletal dysfunction and pain. Several studies suggest that endogenous adenosine may act in an analgesic fashion in various pain states. Objective The purpose of this study was to investigate the contribution of the adenosinergic system on the antihyperalgesic effect of ankle joint mobilization (AJM). Design This was a experimental study. Methods To test the hypothesis that the adrenosinergic system is involved in the antihyperalgesic effect of AJM, mice (25–35 g) submitted to plantar incision surgery were used as a model of acute postoperative pain. The mice were subjected to AJM for 9 minutes. Withdrawal frequency to mechanical stimuli was assessed 24 hours after plantar incision surgery and 30 minutes after AJM, adenosine, clonidine, or morphine treatments. The adenosinergic system was assessed by systemic (intraperitoneal), central (intrathecal), and peripheral (intraplantar) administration of caffeine. The participation of the A1 receptor was investigated using a selective adenosine A1 receptor subtype antagonist. In addition, previous data on the involvement of the serotonergic and noradrenergic systems in the antihyperalgesic effect of AJM were confirmed. Results Ankle joint mobilization decreased mechanical hyperalgesia, and this effect was reversed by pretreatment of the animals with caffeine given by intraperitoneal, intraplantar, and intrathecal routes. In addition, intraplanar and intrathecal administrations of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX, a selective adenosine A1 subtype receptor antagonist) or systemic administration of yohimbine or ρ-chlorophenylalanine methyl ester hydrochloride (PCPA) blocked the antihyperalgesia induced by AJM. Limitations The results are limited to animal models and cannot be generalized to acute pain in humans. Conclusions This study demonstrated the involvement of the adenosinergic system in the antihyperalgesic effect of AJM in a rodent model of pain and provides a possible mechanism basis for AJM-induced relief of acute pain.
Circulating levels of TNF alpha and TNF receptor superfamily members in lymphoid neoplasia.

We have correlated the serum levels of TNF alpha and soluble TNF receptor superfamily members with clinico-pathologic parameters in patients of Hodgkin's disease (HD, N = 26) and non-Hodgkin's lymphoma (NHLs, N = 35). HD patients had significantly higher levels of TNF alpha, sTNFRI, and sTNFRII in serum while NHL patients had significantly higher levels of sTNFRI, sTNFRII, sCD27, and sFas as compared to controls. In NHL patients the levels of sCD27 correlated directly and significantly with the high-stage disease, bone marrow involvement, lymph nodal presentation, and serum LDH levels. Similarly in NHL patients, levels of sFas also correlated directly and significantly with the presence of high stage disease. HD patients with B symptoms had significantly higher levels of sTNFRII.
Kinematic singularity avoidance for robot manipulators using set-based manipulability tasks

This paper proposes a novel method for kinematic singularity avoidance for robot manipulators. Using set-based singularity avoidance tasks within the singularity-robust multiple task priority framework, avoidance of kinematic singularities is guaranteed without interfering with the convergence of compatible equality tasks. Non-compatible equality tasks will still be fulfilled to the extent possible. In addition, the method can be used to reconfigure the robot into a more dexterous configuration. The proposed method is applicable to both redundant and nonredundant robots, with both fixed base and floating base. The implementation is generic and independent of the type and number of tasks. Although also applicable for non-redundant fixed base robot manipulators, this novel approach is particularly well suited for highly redundant and/or floating base manipulators, since the robot configuration can be changed to improve the dexterity of the manipulator arm. We demonstrate the method by applying it to an underwater swimming manipulator, which is an innovative and highly redundant underwater floating base manipulator. Furthermore, simulation results are presented that illustrate and validate the proposed method.
An Unusual Presentation of Lumbosacral Dermal Sinus with CSF Leak and Meningitis

Dermal sinus tracts are common skin manifestations seen with spinal dysraphism. Most of these dermal sinus tracts occur in the lumbosacral region. Though dermal sinus tracts are a common manifestation, their presentation with CSF leak is rare and important as they predispose to recurrent meningitis along with neurological deficits. Here we present an interesting case of a 33-month-old female child with dermal sinus CSF leak, tethered cord and intradural dermoid who presented with meningitis and was treated with excision of the tract, removal of the dermoid and detethering of the cord.
15-Deoxy-Delta12,14-prostaglandin J2 regulates mesangial cell proliferation and death.

BACKGROUND Proliferation of intrinsic glomerular cells is a common response to renal injury. Acutely, proliferation may be beneficial, but sustained glomerular hypercellularity after injury is associated with progressive renal failure. To identify endogenous factors that may be responsible for regulating glomerular cell number, the effects of J-series cyclopentenone prostaglandins (PGs) on human glomerular mesangial cell proliferation and death were examined. METHODS Human mesangial cells were grown in the presence or absence of PGJ2 or its metabolite 15-Deoxy-Delta12,14-PGJ2 (15dPGJ2). The number of viable cells was measured by the reduction of the tetrazolium MTS to a colored formazan product. Apoptosis was assessed by caspase-3 activation and DNA fragmentation. RESULTS PGJ2 at concentrations up to 10 micromol/L caused mesangial proliferation. 15dPGJ2 also caused mesangial proliferation at low concentrations (< or =2.5 micromol/L), but induced mesangial cell death at higher concentrations (>5 micromol/L). Cell death occurred in part through apoptosis, measured as an increase in caspase-3 activity and DNA fragmentation in 15dPGJ2-treated cells. Cell death was associated with a decline in baseline phosphorylation of the survival factor Akt and increased Akt degradation, whereas 15dPGJ2-induced mesangial proliferation was blocked by inhibition of the PI 3-kinase/Akt pathway. 15dPGJ2 is a potent PPARgamma agonist. Like 15dPGJ2, treatment of mesangial cells with thiazolidinedione-type PPARgamma ligands (10 to 20 micromol/L) caused significant cell death, but at lower concentrations also caused a small degree of proliferation. CONCLUSIONS J-series prostaglandins thus may be involved in the initiation of glomerular hypercellularity through Akt-dependent proliferation, and restoration of normal glomerular architecture through PPARgamma-mediated apoptosis. Manipulation of these prostaglandins may be relevant to the treatment of progressive glomerular disease.
Lower limit to the thermal conductivity of disordered crystals.

Measurements of the thermal conductivity above 30 K of mixed crystals with controlled disorder, (KBr${)}_{1\mathrm{\ensuremath{-}}\mathit{x}}$(KCN${)}_{\mathit{x}}$, (NaCl${)}_{1\mathrm{\ensuremath{-}}\mathit{x}}$, (NaCn${)}_{\mathit{x}}$ ${\mathrm{Zr}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{Y}}_{\mathit{x}}$${\mathrm{O}}_{2\mathrm{\ensuremath{-}}\mathit{x}/2}$, and ${\mathrm{Ba}}_{1\mathrm{\ensuremath{-}}\mathit{x}}$${\mathrm{La}}_{\mathit{x}}$${\mathrm{F}}_{2+\mathit{x}}$, support the idea of a lower limit to the thermal conductivity of disordered solids. In each case, as x is increased, the data approach the calculated minimum conductivity based on a model originally due to Einstein. These measurements support the claim that the lattice vibrations of these disordered crystals are essentially the same as those of an amorphous solid.
CAUSES OF MORTALITY IN NORTHERN FUR SEALS (CALLORHINUS URSINUS), ST. PAUL ISLAND, PRIBILOF ISLANDS, ALASKA, 1986–2006

To determine whether infectious diseases might have contributed to the present-day decline of northern fur seals (Callorhinus ursinus), preweaned pups (n=2,735), subadult males (n=98), and adults (n=179) were examined postmortem from 1986 to 2006 on St. Paul Island, Alaska. Gross necropsy findings and histologic lesions were used to determine causes of death. Five general categories of mortality were identified for pups: emaciation (1,454 pups, 53%), trauma (497 pups, 18%), perinatal mortality (516 pups, 19%), infectious diseases (82 pups, 3%), and miscellaneous causes (186 pups, 7%). A condition of unknown etiology characterized by multifocal necrotizing myopathy and cardiomyopathy was found in 92 pups. Thirty-three congenital anomalies were identified in 49 pups, including a rare multicentric ganglioneuro-blastoma. General linear models were used to examine change in pup mortality and condition (i.e., pup mass) over time. The prevalence of perinatal mortality appeared to increase during the study and relative to past reports. Trauma and infectious conditions appeared to decrease slightly from 1986 to 2006. Although relatively stable during this investigation, emaciation was greater than that reported for past studies. Emaciated pups weighed less than expected during 1988, 1996, and 2004 and more than expected during 1987, 1989, 1990, and 1994 (P≤0.003). Average annual weights for all other categories of mortality did not change significantly from 1986 to 2006. Fatal conditions for subadult males included hyperthermia, blunt trauma, entanglement, and bite wounds; nonfatal conditions included seizures, orange discoloration of the blubber, neoplasia, and parasitism. Causes of mortality for most adults included bite wounds with cellulitis and secondary infections, pulmonary edema, dystocia, blunt trauma, and neoplasia. We found no evidence to implicate infectious diseases as a cause in the recent decline of northern fur seals.
Analytical Prediction of Noise of Magnetic Origin Produced by Permanent Magnet Brushless Motors

Prediction of acoustic noise radiated by electric motors is nowadays important both for machine manufacturers and users. This paper describes an engineering approach to prediction of noise of magnetic origin produced by permanent magnet (PM) brushless motors. The sound power level (SWL) is calculated on the basis of magnetic field analysis in the air gap, radial forces, natural frequencies of the stator-frame system and radiation efficiency coefficient. Accuracy problems encountered in the analytical and numerical noise prediction have been discussed.
Multivariate fMRI and Eye Tracking Reveal Differential Effects of Visual Interference on Recognition Memory Judgments for Objects and Scenes

Recent work has demonstrated that the perirhinal cortex (PRC) supports conjunctive object representations that aid object recognition memory following visual object interference. It is unclear, however, how these representations interact with other brain regions implicated in mnemonic retrieval and how congruent and incongruent interference influences the processing of targets and foils during object recognition. To address this, multivariate partial least squares was applied to fMRI data acquired during an interference match-to-sample task, in which participants made object or scene recognition judgments after object or scene interference. This revealed a pattern of activity sensitive to object recognition following congruent (i.e., object) interference that included PRC, prefrontal, and parietal regions. Moreover, functional connectivity analysis revealed a common pattern of PRC connectivity across interference and recognition conditions. Examination of eye movements during the same task in a separate study revealed that participants gazed more at targets than foils during correct object recognition decisions, regardless of interference congruency. By contrast, participants viewed foils more than targets for incorrect object memory judgments, but only after congruent interference. Our findings suggest that congruent interference makes object foils appear familiar and that a network of regions, including PRC, is recruited to overcome the effects of interference.
Evaluation of the FRAX and Garvan fracture risk calculators in older women

Fracture risk calculators estimate the absolute risk of osteoporotic fractures. We investigated the performance of the FRAX and Garvan Institute fracture risk calculators in healthy, older, New Zealand, postmenopausal women with normal bone mineral density (BMD) for their age. Fractures were ascertained in women initially enrolled in a 5‐year trial of calcium supplements and followed on average for 8.8 years. Baseline data (1422 women, mean age 74 years, mean femoral neck BMD T‐score –1.3) were used to estimate fracture risk during follow‐up using the FRAX and Garvan calculators. The FRAX–New Zealand tool was used both with and without baseline BMD. The discrimination of the calculators was assessed using the area under the curve (AUC) of receiver operating characteristic curves. The calibration was assessed by comparing estimated risk of fracture with fracture incidence across a range of estimated fracture risks and clinical factors. For each fracture subtype, the calculators had comparable moderate predictive discriminative ability (AUC range: hip fracture 0.67–0.70; osteoporotic fracture 0.62–0.64; any fracture 0.60–0.63) that was similar to that of models using only age and BMD. The Garvan calculator was well calibrated for osteoporotic fractures but overestimated hip fractures. FRAX with BMD underestimated osteoporotic and hip fractures. FRAX without BMD underestimated osteoporotic and overestimated hip fractures. In summary, none of the calculators provided better discrimination than models based on age and BMD, and their discriminative ability was only moderate, which may limit their clinical utility. The calibration varied, suggesting that the calculators should be validated in local cohorts before clinical use. © 2011 American Society for Bone and Mineral Research.