Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of COX-2/PGE2 Mediated Inflammation in Oral Squamous Cell Carcinoma

A significant amount of research indicates that the cyclooxygenase/prostaglandin E2 (PGE2) pathway of inflammation contributes to the development and progression of a variety of cancers, including squamous cell carcinoma of the oral cavity and oropharynx (OSCC). Although there have been promising results from studies examining the utility of anti-inflammatory drugs in the treatment of OSCC, this strategy has been met with only variable success and these drugs are also associated with toxicities that make them inappropriate for some OSCC patients. Improved inflammation-targeting therapies require continued study of the mechanisms linking inflammation and progression of OSCC. In this review, a synopsis of OSCC biology will be provided, and recent insights into inflammation related mechanisms of OSCC pathobiology will be discussed. The roles of prostaglandin E2 and cluster of differentiation factor 147 (CD147) will be presented, and evidence for their interactions in OSCC will be explored. Through continued investigation into the protumourigenic pathways of OSCC, more treatment modalities targeting inflammation-related pathways can be designed with the hope of slowing tumour progression and improving patient prognosis in patients with this aggressive form of cancer.
Personal Prejudice, Other Guilt: Explicit Prejudice Toward Black People Predicts Guilty Verdicts for White Officers Who Kill Black Men

Across the United States, acquittals of White police officers who have killed Black men have spurred clashes between those who see such situations as manifestations of racism and those who see them as race-irrelevant acts of officer self-defense. In this research, we explore the relationship between participants’ racial prejudice and construal of an event that leads to the death of a Black man. In Study 1, we found that participants’ racial prejudice predicts lower perceived guilt for a White officer who killed a Black man. In Study 2, we found evidence that the relationship between racial prejudice and guilt judgments is driven by increased perceptions that the officer was in danger and decreased perceived relevance of officer prejudice. Finally, Study 3 demonstrated that these patterns hold when the victim is Black, but not White. We conclude that racial prejudice shapes perceptions of legal responsibility for lethal interactions with Black men.
Recognition of Sedentary Behavior by Machine Learning Analysis of Wearable Sensors during Activities of Daily Living for Telemedical Assessment of Cardiovascular Risk

With the recent advancement in wearable computing, sensor technologies, and data processing approaches, it is possible to develop smart clothing that integrates sensors into garments. The main objective of this study was to develop the method of automatic recognition of sedentary behavior related to cardiovascular risk based on quantitative measurement of physical activity. The solution is based on the designed prototype of the smart shirt equipped with a processor, wearable sensors, power supply and telemedical interface. The data derived from wearable sensors were used to create feature vector that consisted of the estimation of the user-specific relative intensity and the variance of filtered accelerometer data. The method was validated using an experimental protocol which was designed to be safe for the elderly and was based on clinically validated short physical performance battery (SPPB) test tasks. To obtain the recognition model six classifiers were examined and compared including Linear Discriminant Analysis, Support Vector Machines, K-Nearest Neighbors, Naive Bayes, Binary Decision Trees and Artificial Neural Networks. The classification models were able to identify the sedentary behavior with an accuracy of 95.00% ± 2.11%. Experimental results suggested that high accuracy can be obtained by estimating sedentary behavior pattern using the smart shirt and machine learning approach. The main advantage of the developed method to continuously monitor patient activities in a free-living environment and could potentially be used for early detection of increased cardiovascular risk.
Here, this and next: evaluating public engagement with multiple, distributed and interlinked devices

Location-based applications have been used to guide users through multiple points of interest, engaging them in the exploration of new places, the collection of items and the practice of exercise. However, existing approaches are often designed for mobile devices, which can be a barrier to more instant and broad access. We examine a new approach for locative media which consists of placing multiple physical and interactive devices in public places. The idea is that when passersby interact with a device, they are encouraged to carry on and discover the others. Through two in-the-wild studies, we investigate how to engage and support such experiences by carefully designing content, spatial arrangement as well as indications to the multiple devices. Findings showed what motivates people to interact with this kind of location-based media, and what discourages them. Such insights can be useful for designers of future multi-device public installations.
Computational Insight Into Vitamin K1 ω-Hydroxylation by Cytochrome P450 4F2

Vitamin K1 (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids. However, the mechanism of VK1 ω-hydroxylation by CYP4F2 has not been disclosed. In this study, we employed a combination of quantum mechanism (QM) calculations, homology modeling, molecular docking, molecular dynamics (MD) simulations, and combined quantum mechanism/molecular mechanism (QM/MM) calculations to investigate the metabolism profile of VK1 ω-hydroxylation. QM calculations based on the truncated VK1 model show that the energy barrier for ω-hydroxylation is about 6-25 kJ/mol higher than those at other potential sites of metabolism. However, results from the MD simulations indicate that hydroxylation at the ω-site is more favorable than at the other potential sites, which is in accordance with the experimental observation. The evaluation of MD simulations was further endorsed by the QM/MM calculation results. Our studies thus suggest that the active site residues of CYP4F2 play a determinant role in the ω-hydroxylation. Our results provide structural insights into the mechanism of VK1 ω-hydroxylation by CYP4F2 at the atomistic level and are helpful not only for characterizing the CYP4F2 functions but also for looking into the ω-hydroxylation mediated by other CYP4 enzymes.
Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein

Myelin sheath formed by oligodendrocytes (OLs) is essential for the rapid propagation of action potentials in the vertebrate CNS. Myelin regulatory factor (MYRF) is one of the critical factors that control OL differentiation and myelin maintenance. Previous studies showed that MYRF is a membrane-bound transcription factor associated with the endoplasmic reticulum (ER). After self-cleavage, the N-fragment of MYRF is released from the ER and translocated into the nucleus where it functions as a transcription factor to activate myelin gene expression. At present, it remains unknown whether MYRF self-cleavage and functional activation can be regulated during OL differentiation. Here, we report that TMEM98, an ER-associated transmembrane protein, is capable of binding to the C-terminal of MYRF and inhibiting its self-cleavage and N-fragment nuclear translocation. In the developing CNS, TMEM98 is selectively expressed in early maturing OLs in mouse pups of either sex. Forced expression of TMEM98 in embryonic chicken spinal cord of either sex suppresses endogenous OL differentiation and MYRF-induced ectopic expression of myelin genes. These results suggest that TMEM98, through inhibiting the self-cleavage of MYRF, functions as a negative feedback regulator of MYRF in oligodendrocyte differentiation and myelination. SIGNIFICANCE STATEMENT MYRF protein is initially synthesized as an ER-associated membrane protein that undergoes autoproteolytic cleavage to release the N-fragment, which is then transported into the nucleus and activates the transcription of myelin genes. To date, the molecular mechanisms that regulate the self-cleavage and function of MYRF in regulating oligodendrocyte differentiation have remained unknown. In this study, we present the molecular and functional evidence that TMEM98 membrane protein physically interacts with MYRF in the ER and subsequently blocks its self-cleavage, N-terminal nuclear translocation, and functional activation of myelin gene expression. To our knowledge, this is the first report on the regulation of MYRF self-proteolytic activity and function by an interacting protein, providing new insights into the molecular regulation of OL differentiation and myelinogenesis.
Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial

Purpose The purpose of this study was to assess the efficacy of perineural dexamethasone with ropivacaine in multimodal analgesia for thoracic paravertebral block (TPVB) in patients undergoing elective thoracotomy. Patients and methods Ninety-six patients undergoing thoracotomy were enrolled in this trial and randomized to adjuvant therapy for TPVB: group S (saline), group R (0.5% ropivacaine), or group RD (5 mg dexamethasone and 0.5% ropivacaine). Postoperative analgesia, recovery duration, and chronic pain were recorded. Results Groups R and RD spent less time in the postanaesthesia care unit, had earlier out-of-bed activity, and had shorter postoperative hospital stays compared with group S. The RD group regained consciousness faster and had lower acute pain scores and used less patient-controlled analgesia during the first 72 h after surgery compared with group S. Postthoracotomy pain was decreased in group RD (19.0%) compared with group S (47.6%) 3 months postoperatively, p = 0.050. Conclusion Perineural dexamethasone with ropivacaine for TPVB improves postoperative analgesia quality, reduces recovery time, and may decrease the incidence of chronic pain after thoracotomy with an opioid-based anesthetic regimen.
Pre-sleep protein in casein supplement or whole-food form has no impact on resting energy expenditure or hunger in women

Abstract The purpose of this study was to determine the effect of a whole-food protein (cottage cheese, CC) consumed before sleep on next-morning resting energy expenditure (REE), RER and appetite compared with an isoenergetic/isonitrogenous casein protein (CP) supplement and placebo (PL) in active women. In a beverage-blinded, randomised, cross-over design, ten active women (age, 23·1 (sd 1·9) years; body fat, 22·0 (sd 4·6) %) consumed pre-sleep CC (30 g of protein, 10 g of carbohydrate and 0 g of fat) or energy- and protein-matched liquid CP or PL (0 kJ). Participants arrived at 18.00 hours for an overnight stay in the laboratory. At 30–60 min before normal bed time (2 h post standard meal), participants consumed CC, CP or PL before measurement of REE. Upon waking (05.00–08.00 hours), REE was repeated and subjective appetite was recorded. Statistical analyses were conducted using repeated-measures ANOVA (SPSS). Significance was accepted at P≤0·05. There were no significant differences in acute REE (CC, 7217 (sd 1368); CP, 7188 (SD 895); PL, 7075 (sd 1108) kJ/d, P=0·95), acute RER (0·79 (sd 0·05), P=0·56), morning REE (CC, 5840 (sd 1225); CP, 5694 (sd 732); PL, 5991 (sd 903) kJ/d, P=0·79) or morning RER (0·77 (sd 0·03), P=0·52). Subjective measures of appetite were not different between groups. In active women, pre-sleep consumption of CC does not alter REE or RER more than a CP or PL beverage. These data suggest that the metabolic response from whole-food protein do not differ from the metabolic response of liquid protein.
Reduced Urban Heat Island intensity under warmer conditions

The Urban Heat Island (UHI), the tendency for urban areas to be hotter than rural regions, represents a significant health concern in summer as urban populations are exposed to elevated temperatures. A number of studies suggest that the UHI increases during warmer conditions, however there has been no investigation of this for a large ensemble of cities. Here we compare urban and rural temperatures in 54 US cities for 2000–2015 and show that the intensity of the Urban Heat Island, measured here as the differences in daily-minimum or daily-maximum temperatures between urban and rural stations or ΔT, in fact tends to decrease with increasing temperature in most cities (38/54). This holds when investigating daily variability, heat extremes, and variability across climate zones and is primarily driven by changes in rural areas. We relate this change to large-scale or synoptic weather conditions, and find that the lowest ΔT nights occur during moist weather conditions. We also find that warming cities have not experienced an increasing Urban Heat Island effect.
Adaptive Shivers Sort: An Alternative Sorting Algorithm

We present one stable mergesort algorithm, called \Adaptive Shivers Sort, that exploits the existence of monotonic runs for sorting efficiently partially sorted data. We also prove that, although this algorithm is simple to implement, its computational cost, in number of comparisons performed, is optimal up to a small additive linear term.
High interindividual variability in plasma clopidogrel active metabolite concentrations in healthy cats is associated with sex and cytochrome P450 2C genetic polymorphism

Clopidogrel response variability has been identified in cats. In humans, evidence suggests that variable clopidogrel active metabolite (CAM) generation is the primary explanation for clopidogrel response variability with differences in body weight, sex, and variable metabolism of clopidogrel primarily due to polymorphisms of the gene encoding cytochrome P450 (CYP) 2C19 as some proposed mechanisms. The aim of this study was to evaluate whether variation in CAM concentrations exists in healthy cats and what the cause of such variation might be. Nineteen healthy cats were given 18.75 mg clopidogrel by mouth. Blood was collected 2 hr later. Plasma CAM concentrations were measured using high performance liquid chromatography and tandem mass spectrometry. Clopidogrel metabolism was estimated by calculating CAM metabolic ratio. DNA was collected, and feline CYP2C genotyping was performed. The cats demonstrated high interindividual variation of plasma CAM concentrations. Approximately 69% of this interindividual variation was primarily explained by differences in clopidogrel metabolism as measured by CAM metabolic ratio with some influence by sex but not by weight. A single nucleotide polymorphism was identified in the feline CYP2C gene that explained in part individual differences in CAM metabolic ratio and CAM plasma concentrations.
A possible key role of vision in the development of schizophrenia

Abstract Based on a brief overview of the various aspects of schizophrenia reported by numerous studies, here we hypothesize that schizophrenia may originate (and in part be performed) from visual areas. In other words, it seems that a normal visual system or at least an evanescent visual perception may be an essential prerequisite for the development of schizophrenia as well as of various types of hallucinations. Our study focuses on auditory and visual hallucinations, as they are the most prominent features of schizophrenic hallucinations (and also the most studied types of hallucinations). Here, we evaluate the possible key role of the visual system in the development of schizophrenia.
Insights into Teacher Education Curriculum in Thailand

Pre-service teacher training is regarded as a crucial factor in promoting the quality of teacher. A variety of pre-service teacher training programmes are introduced such as the five-year programme curricula. However, the study found that student teachers could not make connections between theory from the university and practice into the school. As a result, the standard of pre-service teacher training is elevated to ensure the expertise of student teachers. This study aims to study and identify effective pre-service teacher training programme at the Thai tertiary level. Data were obtained from students studying in the five-year programme curricula in the Faculty of Education. The instrument used in this investigation was a questionnaire with open-ended question. The findings revealed that lecturers were seen to be a key factor in promoting students' learning success and good characteristics of lecturers can be classified into two domains: management and instructional techniques and personal characteristics. This study provides implications for those who would like to promote and improve a teacher training programme, particularly the five-year bachelor's degree programme.
Earthquakes to Floods: A Scoping Review of Health-related Disaster Research in Low- and Middle-income Countries

Introduction: Health-related disaster research is a relatively small; but growing field of inquiry. A better understanding of the scope and scale of health-related disaster research that has occurred in low- and middle-income countries (LMICs) would be useful to funders, researchers, humanitarian aid organizations, and governments as they strive to identify gaps, disparities, trends, and needs of populations affected by disasters. Methodology: We performed a scoping review using the process outlined by Arksey & O’Malley to assess the characteristics of peer-reviewed publications of empirical health-related disaster research conducted in LMICs and published in the years 2003-2012. Results: Five hundred and eighty-two relevant publications were identified. Earthquakes were by far the most commonly researched events (62% of articles) in the review’s timeframe. More articles were published about disasters in China & South Asia/South East Asia than all other regions. Just over half of the articles (51%) were published by research teams in which all the authors’ primary listed affiliations were with an institution located in the same country where the research was conducted. Most of the articles were classified as either mental health, neurology and stress physiology (35%) or as traumatology, wounds and surgery (19%). In just over half of the articles (54%), data collection was initiated within 3 months of the disaster, and in 13% research was initiated between 3 and 6 months following the disaster. The articles in our review were published in 282 different journals. Discussion: The high number of publications studying consequences of an earthquake may not be surprising, given that earthquakes are devastating sudden onset events in LMICs. Researchers study topics that require immediate attention following a disaster, such as trauma surgery, as well as health problems that manifest later, such as post-traumatic stress disorder. One neglected area of study during the review’s timeframe was the impact of disasters on non-communicable and chronic diseases (excluding mental health), and the management of these conditions in the aftermath of disasters. Strengthening disaster research capacity is critical for fostering robust research in the aftermath of disasters, a particular need in LMICs.
Community Assembly in Wastewater-Fed Pilot-Scale Microbial Electrolysis Cells

The formation of an electrochemically active biofilm is critical to the function of a Microbial Electrolysis Cell (MEC). We used Illumina 16S rDNA sequencing to analyse the formation and composition of anodic biofilms of two pilot-scale MECs, operated in continuous flow mode on domestic wastewater for over six months, and inoculated with that same wastewater. We observe: (i) a clear correlation between the frequency of detection of taxa in the MECs and their abundance in the metacommunity, (ii) the existence of a “core community” that was present across sites and (iii) the percentage of Geobacter tended to increase with longevity of retention time of the wastewater in the reactor. This suggests that: (i) community composition was largely governed by stochastic processes, (ii) that the technology should work on most if not all domestic wastewaters, as long as the anodes are seeded with the target wastewater and (iii) that deterministic factors may also play a role in establishing the anodic community. Geobacter, the archetypical electrogen in bioelectrochemical systems, comprised only 1.0 ± 0.7 % of the sequences recovered from a functioning pilot-scale MEC anode. Our results imply that influent flow rate may need to be optimised separately for start-up and for operating conditions for maximal performance.
Monolingual sentence matching for text simplification

This work improves monolingual sentence alignment for text simplification, specifically for text in standard and simple Wikipedia. We introduce a convolutional neural network structure to model similarity between two sentences. Due to the limitation of available parallel corpora, the model is trained in a semi-supervised way, by using the output of a knowledge-based high performance aligning system. We apply the resulting similarity score to rescore the knowledge-based output, and adapt the model by a small hand-aligned dataset. Experiments show that both rescoring and adaptation improve the performance of knowledge-based method.
Combined detection of IL-6 and IL-8 is beneficial to the diagnosis of early stage esophageal squamous cell cancer: a preliminary study based on the screening of serum markers using protein chips

Background The diagnosis rate of early stage esophageal squamous cell carcinoma (ESCC) is low due to the lack of specific tumor markers. Seeking for these markers is beneficial to improve the early diagnosis rate and the prognosis of patients. This study profiles the differentially expressed proteins of early stage ESCC patients via the AAH-BLG-507 protein chip, which further consolidates the clinical evidence of ESCC diagnosis. Materials and methods In this study, 20 serum samples were collected from Taihe Hospital between August 2016 and June 2017. Ten of them carried ESCC, while the rest were healthy controls. To profile the proteins’ expression level, the AAH-BLG-507 protein chip was used, and both highly expressed and lowly expressed proteins were fished out. Meanwhile, their biological roles were examined by using Gene Ontology (GO) database and String database, and they were further verified by ELISA. Results Results showed that the expression levels of AXL, ARTN, Ang2, BDNF, BMP7, cripto-1, CCL28, E-selectin, IL-6, IL-8 and SHH in the serum of early ESCC were significantly upregulated (P<0.05), particularly IL-6 and IL-8. The expression levels of TSP1 and MMP-8 were markedly downregulated (P<0.05). Analysis showed that these proteins were mainly involved in angiogenesis, signal transduction, cell proliferation and migration, indicating the close relationship with the development of ESCC. Conclusion It suggested that IL-6 and IL-8 proteins could be considered as the markers for ESCC diagnosis.