Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of hiking pole inertia on energy and muscular costs during uphill walking.

INTRODUCTION/PURPOSE The purpose of the present study was to investigate the effects of using hiking poles with different inertia on oxygen cost (V O2) and muscular activity. METHODS Eleven subjects walked at 3 km.h on a treadmill inclined at 20% grade. Three mass (240, 300, and 360 g), load distribution, and walking frequency (preferred, -20% and +20%) conditions were tested. Each subject also walked without poles and carried a 360-g mass. V[spacing dot above]O2 and average EMG (aEMG) of nine muscles from lower (soleus, gastrocnemius lateralis, vastus lateralis, biceps femoris, gluteus maximus) and upper (latissimus dorsi, biceps brachii, triceps brachii, and anterior deltoid) limbs were recorded. RESULTS Using poles significantly reduced lower limb muscle aEMG values (P < 0.001) by about 15% and increased upper limb muscle aEMG values (P < 0.001) by about 95%. Hand-masses of 360 g did not result in an increased V[spacing dot above]O2, and the only modification in terms of muscular activation was greater biceps brachii activity (+55%, P = 0.006). Biceps brachii and anterior deltoid activity were also influenced by pole mass and load distribution (P < 0.01). Walking at high frequency increased both aEMG and V[spacing dot above]O2, whereas walking at low frequency redistributed the muscular work from the thigh muscles to calf and upper limb muscles although this did not lead to an increased V[spacing dot above]O2 compared with that at preferred frequency. No interaction between mass and frequency was found for aEMG or V[spacing dot above]O2. CONCLUSION Using poles and changing frequency have important effects on muscle recruitment, whereas the effects of mass were limited when considering poles available on the market.
Experiência clínica na avaliação de 284 casos de erisipela

This study concerns Erysipelas disease in Brazil and is also a warning regarding the importance of preventing its recurrence, which may lead to a clinical picture of elephantiasis and consequent impairment in the domestic, social and professional life of the patient. A retrospective analysis was performed of 284 cases of erysipelas in the period from 1995 to 1996, considering the following features: sex, age, related mapping of the injured tissue, systemic and local predisposition, means of infection, medical treatment, concurrent disease and eventual need for hospitalization. The results showed that males and obese individuals are the most likely to be affected by the disease and especially those from 60 to 70 years old. The inferior members were the most affected by the disease. Skin lesions due to tinea pedis were the main entry site of the bacterial agent. Hospitalization was necessary when the patient presented necrotic lesions. Penicillin G benzathine and crystalline penicillin were the medicines of choice and side effects were not observed in the majority of cases.
Elite long sprint running: a comparison between incline and level training sessions.

PURPOSE We compared incline and level training sessions as usually used in elite 400-m runners through stride kinematics and muscular activity measurements. METHODS Nine highly trained 400-m runners (international and French national level) performed two maximal velocity sprints: 1) 300-m on level ground (LEV) and 2) 250-m on an incline ground (INC) characterized by a mean +/- SD grade of 5.4 +/- 0.7%. Kinematics (250 Hz) and electromyography parameters (root mean square [RMS] and integrated electromyography [iEMG] measurements) were analyzed (from 40- to 50-m phases). RESULTS INC induced a decrease in running velocity compared to LEV (6.28 +/- 0.38 vs 7.56 +/- 0.38 m.s) explained by a reduction in stride length (-14.2%) and stride rate (-7.4%) and by an increase in push-off time (+26.4%). Kinematics analysis indicated that the lower limbs were more flexed during INC running. Concerning the level of activity of the lower limb muscles, the major findings pointed out the decrease in RMS for semitendinosus and biceps femoris muscles during the contact phase and for vastus lateralis during its concentric phase. However, iEMG of both semitendinosus and biceps femoris muscles remained constant during both contact and push-off phases. CONCLUSION Our results are clearly different from those of previous studies carried out at similar absolute velocities in both LEV and INC conditions, which were not the case in this study. The lower running velocity marking INC running was associated with a decrease in the activation of the hamstrings. Trainers should particularly consider this lower level of activation of the hamstrings muscles during INC maximal sprint.
Exercise-induced oxidative DNA damage and lymphocytopenia in sedentary young males.

UNLABELLED Post high-intensity exercise lymphocytopenia is well documented, but its underlying mechanisms have not been fully elucidated. A possible mechanism is a reactive oxygen species-induced DNA damage after high-intensity exercise. Furthermore, lymphocyte apoptosis related to DNA damage might contribute to exercise-induced lymphocytopenia. PURPOSE This study examined lymphocytopenia, lymphocyte oxidative DNA damage, and apoptosis in young healthy sedentary males after acute high-intensity exercise. METHOD Fifteen subjects exercised on bicycle ergometers for 1 h at 75% of their VO2max. Venous blood samples were taken before exercise (PRE) and hourly after exercise until 4 h (P0-P4). Lymphocyte counts, oxidative DNA damage evaluated using the Comet assay with human 8-oxoguanine DNA glycosylase, and serum lipid peroxide (LPO) concentration were measured. Furthermore, lymphocyte superoxide, Fas receptor (CD95), and Annexin-V-positive lymphocyte apoptosis cells were measured in 10 subjects who exercised and gave blood samples as described above. RESULTS Lymphocyte counts became significantly lower than the PRE value (P < 0.05): 20.4% at P1, 24.3% at P2, and 16.3% at P3. Moreover, LPO significantly increased by P2 (P < 0.05): 1.6-fold. The % DNA in tail, indicating oxidative DNA damage, was significantly higher at P3 (54.3 +/- 12.8%) than at PRE (42.6 +/- 11.1%, P < 0.05). The lymphocyte superoxide level was significantly higher (51.3%) than the PRE value (P < 0.05). Neither CD95 nor Annexin-V-positive cells were significantly different than the PRE value. CONCLUSION Results of this study suggest that lymphocyte oxidative DNA damage can relate to lymphocytopenia, although DNA damage was not associated with apoptosis in healthy young sedentary males.
The effect of aerobic exercise on neutrophil functions.

PURPOSE Intense exercise bouts are associated with a reduction of immune function and increased susceptibility to infections. Neutrophils act as a first line of defense to eliminate infectious agents and are also involved in muscle tissue inflammatory response to exercise. Intensive exercise suppresses several neutrophil functions including chemotaxis. The study investigates the pathophysiological mechanisms of impaired chemotaxis after submaximal aerobic exercise. METHODS Twenty-three healthy physically active adult males were tested before and 24 h after 30 min of treadmill running at 75% VO2max. N-formyl-Met-Leu-Phe (fMLP)-stimulated neutrophil migration, polarization, adherence, expression of adhesion molecules (CD11b/CD18), and chemotactic receptor (C5aR) were assessed preexercise and postexercise. RESULTS Neutrophil chemotaxis and polarization were found to be impaired 24 h postexercise. Adherence was impaired 24 h postexercise as well, but the expression of the adhesion molecule CD11b/CD18 was not affected. Further, the availability of the C5aR was found to be unaffected 24 h postaerobic exercise. CONCLUSIONS The pathophysiological mechanism of the impaired chemotaxis is likely related to the impaired postexercise neutrophil adherence and polarization but not to changes in the chemotactic receptor availability.
Caffeine supplementation and multiple sprint running performance.

PURPOSE The aim of this study was to examine the effects of caffeine supplementation on multiple sprint running performance. METHODS Using a randomized double-blind research design, 21 physically active men ingested a gelatin capsule containing either caffeine (5 mg x kg(-1) body mass) or placebo (maltodextrin) 1 h before completing an indoor multiple sprint running trial (12 x 30 m; repeated at 35-s intervals). Venous blood samples were drawn to evaluate plasma caffeine and primary metabolite concentrations. Sprint times were recorded via twin-beam photocells, and earlobe blood samples were drawn to evaluate pretest and posttest lactate concentrations. Heart rate was monitored continuously throughout the tests, with RPE recorded after every third sprint. RESULTS Relative to placebo, caffeine supplementation resulted in a 0.06-s (1.4%) reduction in fastest sprint time (95% likely range = 0.04-0.09 s), which corresponded with a 1.2% increase in fatigue (95% likely range = 0.3-2.2%). Caffeine supplementation also resulted in a 3.4-bpm increase in mean heart rate (95% likely range = 0.1-6.6 bpm) and elevations in pretest (+0.7 mmol x L(-1); 95% likely range = 0.1-1.3 mmol x L(-1)) and posttest (+1.8 mmol x L(-1); 95% likely range = 0.3-3.2 mmol x L(-1)) blood lactate concentrations. In contrast, there was no significant effect of caffeine supplementation on RPE. CONCLUSION Although the effect of recovery duration on caffeine-induced responses to multiple sprint work requires further investigation, the results of the present study show that caffeine has ergogenic properties with the potential to benefit performance in both single and multiple sprint sports.
Gender differences in time-frequency EMG analysis of unanticipated cutting maneuvers.

PURPOSE The purpose of this study is to compare the time-frequency characteristic, using nonlinearly scaled wavelets, of the EMG signal as well as the three-dimensional (3D) knee kinematics of female and male elite soccer players performing an unanticipated cutting maneuver. METHODS Fifteen female and 15 male elite soccer players performed several cutting maneuvers during which EMG of eight muscles of the leg and 3D kinematics of the knee were recorded. To create an unanticipated condition, the participants executed one of three tasks, which were signaled to them with an illuminated target board. RESULTS Male participants generally executed the unanticipated cutting maneuver with a quadriceps activation of higher frequency components. These gender differences were also found at initial ground contact (IC) for the vastii and biceps femoris (BF) muscles. These higher frequencies dominated the signal earlier in time for the BF and later for the tibialis anterior (TA) in women. Furthermore, women performed the cutting task with greater knee abduction than did the men. CONCLUSION Female athletes adopted a different motor unit recruitment strategy that was particularly evident at, and near, IC resulting in lower frequency components in the EMG signal of the lateral hamstring. This strategy may play a role in explaining the gender bias in anterior cruciate ligament (ACL) injury rates. Gender differences in knee kinematics were also observed, exposing the female ACL to higher strain, which may be the result of differences in neuromuscular strategies to stabilize the knee joint.
Influences of normobaric hypoxia training on metabolic risk markers in human subjects.

PURPOSE Endurance exercise and hypoxia regulate pathways that are crucial to glucose and lipid metabolism. We hypothesized that training under hypoxia results in similar or even greater metabolic improvement compared with exercise under normoxia at a lower workload. METHODS We randomly assigned 20 healthy men to single blind training under hypoxia (FiO2 = 15%) or normoxia (FiO2 = 21%). Subjects trained thrice weekly for 60 min over a 4-wk period at a heart rate measured at 3 mmol x L(-1) lactate during pretraining exercise testing. Before and after the training period, we determined body composition, venous blood parameters, oral glucose tolerance, and blood pressure. Furthermore, we assessed oxygen uptake (VO2), lactate, and respiratory quotient, and heart rate (HR) during incremental exercise testing, both in hypoxia and in normoxia. Training workload was 1.39 +/- 0.2 W x kg(-1) in the hypoxia and 1.67 +/- 0.15 W x kg(-1) in the normoxia group (P< 0.001) with an identical training heart rate in both groups. RESULTS Exercise capacity improved similarly with both interventions. With hypoxia training, body fat content, triglycerides, HOMA-Index, fasting insulin (P < 0.05), and area under the curve for insulin (P < 0.01) during the oral glucose tolerance test improved more than with the training in normoxia. We did not observe major changes in adipokine measurements. CONCLUSION Endurance training in hypoxia over a 4-wk period elicits a similar or even better response in terms of cardiovascular and metabolic risk factors than endurance exercise in normoxia. The fact that workload and, therefore, mechanic strain can be reduced in hypoxia could be particularly beneficial in obese patients and in patients with orthopedic conditions.
Efficacy of eat-on-move ration for sustaining physical activity, reaction time, and mood.

UNLABELLED Repeated carbohydrate feedings and caffeine have been shown to increase self-paced physical activity. Whether a field ration pack that promotes snacking of these items would enhance physical activity remains unclear. PURPOSE Evaluate the effectiveness of a ration pack consisting of eat-on-move items to promote snacking, as well as caffeine items, as a nutritional strategy to improve performance. METHODS Twenty-eight wildland firefighters consumed both an eat-on-move ration (first strike ration (FSR): 13.2 MJ, 420 g CHO, 665 mg caffeine daily) and entrée-based ration (meals, ready-to-eat (MRE): 11.9 MJ, 373 g CHO, 100 mg caffeine daily) for 2 d separated by 1 d. Diet order was counterbalanced. Outcome measurements included self-paced physical activity determined by actimetry, reaction time, number of eating occasions using dietary recall, and dietary intake from food wrapper collection. RESULTS Total eating episodes were higher with FSR compared with MRE (P = 0.013; mean +/- SD: 8.2 +/- 1.3 vs 7.6 +/- 1.1 episodes x 2 d(-1)), as were 2-d energy intake (22.0 +/- 2.4 vs 18.4 +/- 2.5 MJ; P < 0.01), carbohydrate intake (698 +/- 76 vs 546 +/- 82 mg; P < 0.01), self-reported caffeine intake (347 +/- 262 vs 55 +/- 65 mg; P < 0.01), and average end-shift salivary caffeine (1.6 +/- 1.9 vs 0.7 +/- 1.0 microg x mL(-1); P < 0.01). Total activity counts were higher (P = 0.046) when consuming FSR (507,833 +/- 129,130 counts per shift) compared with MRE (443,095 +/- 142,208 counts per shift). This was accomplished by spending a greater percentage of work shift with activity counts >1000 counts x min(-1) (21 +/- 8% vs 18 +/- 6%; P = 0.01) and less percent of work shift <50 counts x min(-1) (33 +/- 10% vs 38 +/- 10%; P = 0.01). CONCLUSIONS Delivery of energy and caffeine in a manner that promotes snacking behavior is advantageous for increasing self-selected physical activity during arduous labor.
The contribution of clinical placement to nutrition and dietetics competency development: A student-centred approach

Aim: The aim of the present study was to explore the student perception of competency development in nutrition and dietetics and the perceived impact of pre-placement preparation, the clinical placement learning environment, learning exposures and supervision on this. Methods: A qualitative investigation using semistructured interviews with 26 graduate students who had recently completed their final clinical placement, recruited purposively from three Australian universities was employed. Thematic analysis of the interview transcripts and triangular analysis of data was undertaken by the research team, with a mix of descriptive and interpretive analysis. Results: Students across all three universities generally described the placement experience as intense, personally challenging and a steep learning curve. Students felt they had adequate theoretical knowledge prior to placement but were less prepared for the practical application of their skills in a clinical setting. The learning environment varied across placement sites, with physical, organisation and social environmental factors all contributing to the students reported pathway to confidence and competence in practice. The style of supervision and supervisory practices varied considerably and emerged as a significant factor impacting on competency development. Conclusions: Nutrition and dietetic students appear to have a hierarchy of psychosocial and educational needs that need to be met in the placement environment in order to achieve competency. The present study provides a framework for enhancing the student experience and the effectiveness of clinical placements as a component of dietetic workforce preparation.
Breaking e-banking CAPTCHAs

Many financial institutions have deployed CAPTCHAs to protect their services (e.g., e-banking) from automated attacks. In addition to CAPTCHAs for login, CAPTCHAs are also used to prevent malicious manipulation of e-banking transactions by automated Man-in-the-Middle (MitM) attackers. Despite serious financial risks, security of e-banking CAPTCHAs is largely unexplored. In this paper, we report the first comprehensive study on e-banking CAPTCHAs deployed around the world. A new set of image processing and pattern recognition techniques is proposed to break all e-banking CAPTCHA schemes that we found over the Internet, including three e-banking CAPTCHA schemes for transaction verification and 41 schemes for login. These broken e-banking CAPTCHA schemes are used by thousands of financial institutions worldwide, which are serving hundreds of millions of e-banking customers. The success rate of our proposed attacks are either equal to or close to 100%. We also discuss possible improvements to these e-banking CAPTCHA schemes and show essential difficulties of designing e-banking CAPTCHAs that are both secure and usable.
Where are youth active? Roles of proximity, active transport, and built environment.

PURPOSE This study examined factors related to two sources of physical activity for youth: active use of recreation sites and active transport to recreation sites. METHODS Parents of children (n = 87) and matched pairs of parents and adolescents (n = 124 pairs) in three US cities reported on youths' active use of, proximity to, and walking/biking to 12 recreation sites and on neighborhood walkability and safety. Multivariate regression models evaluated factors associated with youths' frequent site use and active transport to sites. RESULTS Proximity to the site was associated with frequent use of large parks and public open space. Walking/biking to the site was associated with frequent use of most sites (indoor recreation sites, small and large parks, basketball courts, walking/running tracks, school recreation sites, playgrounds, and public open space). After controlling for proximity and demographic factors, active transport to sites remained significantly associated (P < 0.05) with frequent use of four sites for children (indoor recreation, walking/running tracks, school recreation facilities, and public open space) and all but three sites for adolescents (indoor recreation, playfields/courts, and beach/lake/rivers). Adolescents' active transport to more sites was most positively related to higher perceived traffic safety and to better pedestrian infrastructure and was negatively related to crime threat. Adolescents with driver's licenses walked/biked to recreation sites less often. CONCLUSIONS Active transport was strongly associated with the use of multiple recreation sites by children and adolescents, even when accounting for proximity and demographic factors. Adolescents living in neighborhoods with better traffic safety walked/biked to more recreation sites for physical activity. Findings support the need for built environments and transportation policies that facilitate safe, active transport to recreation sites for youth physical activity.
Characterization of an ectopic beta-globin LCR: Good neighbors and a distant friend

textabstractThe work discussed in this thesis is aimed at answering questions related to nuclear and chromatin organization, and to functioning of the β-globin LCR. In the introduction these topics are introduced and questions regarding their function are being posed. In the following four experimental chapters, the functional role of the LCR on nuclear and chromatin organization is addressed. In all chapters, the framework for the study is shortly introduced and the results are discussed within this framework. In Chapter 7, general conclusions are drawn from the total work in this thesis.
Exercise capacity in the heat is greater in the morning than in the evening in man.

PURPOSE This study investigated the effect of time of day on endurance exercise capacity in a warm environment. METHODS Nine males cycled to exhaustion at 65% . VO2peak in an ambient temperature of 35 degrees C (60% relative humidity) at 0645 h (AM) and 1845 h (PM). Rectal temperature (Tc), skin temperature (Tsk), and heart rate (HR) were recorded and blood and expired air samples collected at rest every 5 min during exercise and during recovery. RESULTS Time to exhaustion was longer in the AM trial (45.8 +/- 10.7 min) than in the PM trial (40.5 +/- 9.0 min; P = 0.009). Resting Tc was lower in the AM trial and remained lower for the first 25 min of exercise (P < 0.001). Tc was not different between trials at the point of exhaustion (AM = 38.7 +/- 0.9 degrees C, PM = 38.8 +/- 0.6 degrees C; P = 0.847). Tsk followed a similar pattern, being lower at rest (P = 0.003) and during the initial stages of exercise (P < 0.05) in the AM trial but not different at exhaustion (P = 0.896). The rate of rise of Tc tended to be greater in the AM trial (P = 0.052), and the rate of rise of Tsk (P = 0.032) and of body heat content (P = 0.009) was also greater in the AM trial. HR was initially higher in the PM trial, but there was no difference at exhaustion. There were no differences between trials in blood glucose concentration or plasma volume change. CONCLUSION The results of this study suggest that endurance exercise capacity in the heat was significantly greater in the morning than the evening, possibly due to a lower initial Tc.
MAGNETIC RESONANCE, ULTRASOUND AND HISTOPATHOLOGIC CORRELATION OF ACUTE AND HEALING EQUINE TENDON INJURIES

Ultrasonography and MRI have become valuable tools for imaging of tendon injuries. The current study examines the histopathologic basis for the imaging abnormalities. Five injured equine forelimbs and two normal contralateral limbs were studied with high resolution real time ultrasound and MRI. Histologic sections were made and correlated with the diagnostic images. All lesions were readily seen by both modalities. Lesions characterized by hemorrhage, edma, and cellular infiltration were sonolucent on ultrasound and bright on MRI images. MRI returned to normal as fibrogenesis ensued. Ultrasound images remained abnormal until fibrillar reallgnment occured with completion of the healing process. High resolution real time ultrasound and MRI both accurately reflect the tissue abnormalities in acute tendon injuries. The injured horse does appear to be an effective model for correlative imaging studies of tendon injuries.