Miracle-dz/UniFAR-FTUs huggingface dataset:
Local Algorithms for Hierarchical Dense Subgraph Discovery

Finding the dense regions of a graph and relations among them is a fundamental problem in network analysis. Core and truss decompositions reveal dense subgraphs with hierarchical relations. The incremental nature of algorithms for computing these decompositions and the need for global information at each step of the algorithm hinders scalable parallelization and approximations since the densest regions are not revealed until the end. In a previous work, Lu et al. proposed to iteratively compute the h -indices of neighbor vertex degrees to obtain the core numbers and prove that the convergence is obtained after a finite number of iterations. This work generalizes the iterative h -index computation for truss decomposition as well as nucleus decomposition which leverages higher-order structures to generalize core and truss decompositions. In addition, we prove convergence bounds on the number of iterations. We present a framework of local algorithms to obtain the core, truss, and nucleus decompositions. Our algorithms are local, parallel, offer high scalability, and enable approximations to explore time and quality trade-offs. Our shared-memory implementation verifies the efficiency, scalability, and effectiveness of our local algorithms on real-world networks.
Association of autoimmunity and long‐term complete remission in patients with Sézary syndrome treated with mogamulizumab

Long-term complete remissions (CR) are rare in advanced cutaneous T-cell lymphomas (CTCL). Treatment with mogamulizumab, a monoclonal antibody targeting CC chemokine receptor 4 (CCR4), has recently shown to increase progression-free survival compared to vorinostat in previously treated CTCL (1). CCR4 is consistently expressed by Sezary cells, and also by natural regulatory T cells (Tregs). Treatment with mogamulizumab results in a significant and lasting decrease in blood CD4+ CD25+ FoxP3+ Tregs. We report long-lasting CR associated with autoimmune manifestations in two Sezary syndrome (SS) patients treated with mogamulizumab. This article is protected by copyright. All rights reserved.
FcRn Expression in Wildtype Mice, Transgenic Mice, and in Human Tissues

Quantitative real-time PCR and Western blot methods were developed to assess neonatal Fc-receptor (FcRn) mRNA and protein expression in human FcRn transgenic mice, Swiss Webster mice, and in select human tissues. Additionally, FcRn turnover was evaluated via pulse-chase. FcRn mRNA expression was significantly higher in transgenic mice when compared to mouse FcRn mRNA in Swiss Webster mice and it ranged from 184-fold higher in the kidney to 109,000-fold higher in the skin. FcRn protein expression was found to be 13-fold lower in kidney to 5.6-fold higher in lung obtained from transgenic mice compared to FcRn protein expression in lung samples obtained from Swiss Webster mice. FcRn protein expression in human liver and small intestine tissues matched more closely with FcRn expression in Swiss Webster mice but were significantly lower when compared to values found from Swiss Webster and transgenic mice. Although FcRn mRNA expression correlated significantly with protein expression (p < 0.0005), the correlation coefficient was only 0.113. As such, the measurement of FcRn protein may be preferred to FcRn mRNA for quantitative applications. Significant differences were found in FcRn expression in transgenic mice, Swiss Webster mice, and human tissues, which may have implications for the use of mouse models in the assessment of monoclonal antibody disposition, efficacy, and safety.
The morphology of the fourth abdominal ganglion of the hermit crab: A light microscope study

The hermit crab, Pagurus pollicarus, has the same organization in its fourth abdominal ganglion as its macruran relatives in spite of the reduction in abdominal muscles, sensory receptors, and appendages. Connective axons are grouped into discrete bundles between which five groups of commissural fibers run to connect left and right sides. The neurites of ventral cell bodies run dorsally in characteristic groups between the connective bundles. The hermit crab fourth ganglion has two thirds as many cells as the crayfish and is laterally compressed. This reduction appears related to the reduction in the sizes of the ganglionic roots. The ventral fine fibered neuropil is larger on the left than the right side reflecting the loss of pleopods on the right side. The basic organization of decapod abdominal ganglia appears to permit considerable integrative flexibility within a relatively conservative morphological framework.
Job motivation and self-confidence for learning and development as predictors of support for change

Abstract For the most part, studies on change management have attempted to determine the factors that influence employee resistance to change. The focus of the present study is to test whether job motivation and self-confidence for learning and development influence employee support for downsizing. Data were gathered from a sample of 86 teachers at one private school in Bangkok, Thailand. The analysis was carried out using multinomial ordered probit regression. The results suggest that the level of job motivation is negatively associated with the level of support for change, and that the level of self-confidence for learning and development is not associated with the level of support for change. These results are counterintuitive, and they refute our initial hypotheses.
Transforming agency and structure for facilitating pro-poor governance in community forestry

Nepali society is differentiated by hierarchical and discriminatory social structures struggling for transformation. This culture is also reflected in the practices of Community Forestry. Community Forestry is expected to contribute to improved livelihoods within communities through forest management, ensuring social justice through the provision of better spaces and positions to poor and disadvantaged groups. Based on the lessons of nine Community Forest User Groups of seven districts of the hill and Terai regions of Nepal, we propose a more inclusive and interactive process, known as 'Social and Transformative Learning' or 'Action and Learning', which has greater ability to transform both agency and structure to ensure deliberative and pro-poor governance.
Virological remission after antiretroviral therapy interruption in female African HIV seroconverters

Introduction: There are few data on the frequency of virological remission in African individuals after treatment with antiretroviral therapy (ART) in primary HIV infection (PHI). Methods: We studied participants (n = 82) from South Africa and Uganda in Short Pulse Antiretroviral Treatment at HIV-1 Seroconversion, the first trial of treatment interruption in African individuals with PHI randomized to deferred ART or 48 weeks of immediate ART. All were female and infected with non-B HIV subtypes, mainly C. We measured HIV DNA in CD4+ T cells, CD4+ cell count, plasma viral load (pVL), cell-associated HIV RNA and T-cell activation and exhaustion. We explored associations with clinical progression and time to pVL rebound after treatment interruption (n = 22). Data were compared with non-African Short Pulse Antiretroviral Treatment at HIV-1 Seroconversion participants. Results: Pretherapy pVL and integrated HIV DNA were lower in Africans compared with non-Africans (median 4.16 vs. 4.72 log10 copies/ml and 3.07 vs. 3.61 log10 copies/million CD4+ T cells, respectively; P < 0.001). Pre-ART HIV DNA in Africans was associated with clinical progression (P = 0.001, HR per log10 copies/million CD4+ T cells increase (95% CI) 5.38 (1.95–14.79)) and time to pVL rebound (P = 0.034, HR per log10 copies/ml increase 4.33 (1.12–16.84)). After treatment interruption, Africans experienced longer duration of viral remission than non-Africans (P < 0.001; HR 3.90 (1.75–8.71). Five of 22 African participants (22.7%) maintained VL less than 400 copies/ml over a median of 188 weeks following treatment interruption. Conclusion: We find evidence of greater probability of virological remission following treatment interruption among African participants, although we are unable to differentiate between sex, ethnicity and viral subtype. The finding warrants further investigation.
Excess Postexercise Oxygen Consumption and Fat Utilization Following Submaximal Continuous and Supramaximal Interval Running

ABSTRACT Purpose: Few studies have directly compared excess postexercise oxygen consumption (EPOC) and fat utilization following different exercise intensities, and the effect of continuous exercise exceeding 75% of maximal oxygen uptake (VO2max) on these parameters remains unexplored. The current study examined EPOC and fat utilization following acute moderate- and vigorous-intensity continuous training (MICT and VICT) and sprint interval training (SIT). Methods: Eight active young men performed 4 experimental sessions: (a) MICT (30 min of running at 65% VO2max); (b) VICT (30 min of running at 85% VO2max); (c) SIT (4 30-s “all-out” sprints with 4 min of rest); and (d) no exercise (REST). Excess postexercise oxygen consumption and fat oxidation were estimated from gas measurements (VO2 and carbon dioxide production [VCO2]) obtained during a 2-hr postexercise period. Results: Total EPOC was similar (p = .097; effect size [ES] = 0.3) after VICT (8.6 ± 4.7 L) and SIT (10.0 ± 4.2 L) and greater after both (VICT, p = .025, ES = 0.3, and SIT, p < .001, ES = 0.6) versus MICT (6.0 ± 4.3 L). Fat utilization increased after MICT (0.047 ± 0.018 g· min−1, p = .018, ES = 1.3), VICT (0.066 ± 0.020 g•min−1, p = .034, ES = 2.2), and SIT (0.115 ± 0.026 g•min−1, p < .001, ES = 4.0) versus REST (0.025 ± 0.018 g•min−1) and was greatest after SIT (p < .001, ES = 3.0 vs. MICT; p = .031, ES = 2.1 vs. VICT). Conclusion: Acute exercise increases EPOC and fat utilization in an intensity-dependent manner.
Developmental and neurodegenerative damage in Friedreich's ataxia

Friedreich's ataxia (FRDA) is the most common autosomal‐recessive ataxia worldwide. It is characterized by early onset, sensory abnormalities and slowly progressive ataxia. All magnetic resonance imaging (MRI)‐based studies have focused on the evaluation of adult patients. Therefore, we designed a cross‐sectional multimodal MRI‐based study to investigate the anatomical substrates involved in the early stages of FRDA.
Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Sudden Sensorineural Hearing Loss

Objective: Sudden sensorineural hearing loss (SSNHL) is a common acute disease with an incidence of 0.5–2/10,000. This study aimed to determine whether the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) could be indicators for SSNHL. Methods: A total of 60 confirmed cases of SSNHL and 60 healthy volunteers were included in this study. Peripheral blood NLRs and PLRs were compared between these groups. The SSNHL patients were divided into two groups, according to therapeutic effect: an effective group and an ineffective group. Peripheral blood NLRs and PLRs before and after treatment were compared between these two groups. Results: The average NLRs and PLRs of these patients were both significantly higher than in controls. The average NLRs and PLRs of the ineffective group were both significantly higher than those of the effective group. Conclusion: Peripheral blood NLR and PLR could be used as a convenient, reliable, and cost-effective indicator to predict the prognosis of SSNHL.
Changing Interpretations of Emotional Expressions in Working Memory With Aging

Working memory (WM) shows significant decline with age. It is interesting to note that some research has suggested age-related impairments can be reduced in tasks that involve emotion-laden stimuli. However, only a few studies have explored how WM for emotional material changes in aging. Here we developed a novel experimental task to compare and contrast how emotional material is represented in older versus younger adults. The task enabled us to separate overall WM accuracy from emotional biases in the content of affective representations in WM. We found that, in addition to overall decline in WM performance, older adults showed a systematic positivity bias in representing information in WM relative to younger adults (positivity effect). They remembered fearful faces as being less fearful than younger adults and interpreted ambiguous facial expressions more positively. The findings show that aging brings a type of positivity bias when picking up affective information for guiding future behavior.
Characterization of small fiber pathology in a mouse model of Fabry disease

Fabry disease (FD) is a life-threatening X-linked lysosomal storage disorder caused by α-galactosidase A (α-GAL) deficiency. Small fiber pathology and pain are major FD symptoms of unknown pathophysiology. α-GAL deficient mice (GLA KO) age-dependently accumulate globotriaosylceramide (Gb3) in dorsal root ganglion (DRG) neurons paralleled by endoplasmic stress and apoptosis as contributors to skin denervation. Old GLA KO mice show increased TRPV1 protein in DRG neurons and heat hypersensitivity upon i.pl. capsaicin. In turn, GLA KO mice are protected from heat and mechanical hypersensitivity in neuropathic and inflammatory pain models based on reduced neuronal Ih and Nav1.7 currents. We show that in vitro α-GAL silencing increases intracellular Gb3 accumulation paralleled by loss of Nav1.7 currents, which is reversed by incubation with agalsidase-α and lucerastat. We provide first evidence of a direct Gb3 effect on neuronal integrity and ion channel function as potential mechanism underlying pain and small fiber pathology in FD.
Heterotypic trajectories of dimensional psychopathology across the lifespan: the case of youth-onset attention deficit/hyperactivity disorder.

BACKGROUND Recent studies have demonstrated the existence of a distinct late-onset attention deficit/hyperactivity disorder (ADHD) trajectory. Our objective is to test if there are distinct ADHD trajectories regarding age of onset from childhood to adolescence and to compare clinical manifestations, cognitive functions and genetic risk for ADHD among distinct longitudinal groups. METHOD Nine hundred and twenty four children and adolescents from the community participated in the study. We compared clinical, cognitive features and genetic risk among four groups of participants: (a) childhood-limited, (b) youth-onset, (c) childhood-onset with youth persistence, and (d) community comparisons without ADHD. Symptomatic and diagnostic assessments were performed using the Development and Well-Being Behavior Assessment, the Strengths and Difficulties Questionnaire, and the Child Behavior Checklist. Cognitive functions were measured using a battery of standardized tests. Genetic risk for ADHD was calculating using summary statistics from the Psychiatric Genomics Consortium. RESULTS Half of the adolescents (52%) with ADHD had their symptom onset in adolescence. The impairment level of this group in adolescence is similar to the persistent group. Despite not having ADHD, the youth-onset group already presented in childhood more symptoms from other domains of psychopathology, higher shared variance in psychiatric symptomatology (p-factor), school impairment, and executive dysfunctions than community comparisons. Furthermore, the youth-onset group presented lower levels of genetic risk for ADHD compared to other cases. CONCLUSIONS A significant proportion of adolescents with ADHD were youth-onset cases and presented similar impairment levels as those cases with early-onset ADHD. The presence of cognitive impairments and higher levels of clinical symptoms in the youth-onset group already at childhood speaks in favor of a heterotypic trajectory of psychopathology suggesting that youth-onset ADHD might be an artificial consequence of categorizing dimensional psychopathology into discrete diagnostic groups.
Intraventricular hemorrhage risk factors in very low birth weight newborns: a case-control study

Objective: Identification of variables that affect the risk of severe intraventricular hemorrhage (IVH) in very low birth weight (VLBW) newborns. Methods: Analytic case-control study, in a population consisting of all VLBW newborns admitted to the Neonatal Intensive Care Unit of a maternity hospital, between January 2002 and December 2007. The authors considered as cases all VLBW newborns with severe IVH (grade ≥ 3), and control all VLBW newborns without IVH. Independent variables included obstetric, perinatal and neonatal diagnosis and therapy. Bivariate analysis and multivariate logistic regression analysis were performed. results: During this period, of the 864 VLBW newborns admitted to the Neonatal Intensive Care Unit, 9.7% had severe IVH. With bivariate analysis an association between severe IVH, gestational age and birth weight was found. Prenatal care and pre-eclampsia were associated with a decrease in the incidence of severe IVH. Amnionitis, being outborn, vaginal delivery, male gender, intubation in the delivery room, surfactant, hyaline membrane disease, pneumothorax, necrotizing enterocolitis (NEC) perforation and oscillatory high frequency ventilation were associated with an increased incidence of severe IVH. By multivariate logistic regression, the variables associated with increased risk of severe IVH were: pneumothorax (OR = 3.8; 95%CI = 1.7-8.3), NEC with perforation (OR = 8.8; 95%CI = 1.7-45.0), vaginal delivery (OR = 2.0; 95%CI = 1.0-4.1) and high frequency ventilation (OR = 4.8; 95%CI = 1.3-17.3). The following were protective of severe IVH: gestational age (OR = 0.61; 95%CI = 0.52-0.72), patent ductus arteriosus treatment with indomethacin (OR = 0.26; 95%CI = 0.11-0.6) and fertility treatment (OR = 0.24; 95%CI = 0.06-0.94). conclusion: These data outline the importance of improvement of pre and neonatal care to reduce severe IVH.
Group 3 ITI Consensus Report: Patient‐reported outcome measures associated with implant dentistry

OBJECTIVES The aim of Working Group 3 was to focus on three topics that were assessed using patient-reported outcome measures (PROMs). These topics included the following: (a) the aesthetics of tooth and implant-supported fixed dental prostheses focusing on partially edentulous patients, (b) a comparison of fixed and removable implant-retained prostheses for edentulous populations, and (c) immediate versus early/conventional loading of immediately placed implants in partially edentate patients. PROMs include ratings of satisfaction and oral health-related quality of life (QHRQoL), as well as other indicators, that is, pain, general health-related quality of life (e.g., SF-36). MATERIALS AND METHODS The Consensus Conference Group 3 participants discussed the findings of the three systematic review manuscripts. Following comprehensive discussions, participants developed consensus statements and recommendations that were then discussed in larger plenary sessions. Following this, any necessary modifications were made and approved. RESULTS Patients were very satisfied with the aesthetics of implant-supported fixed dental prostheses and the surrounding mucosa. Implant neck design, restorative material, or use of a provisional restoration did not influence patients' ratings. Edentulous patients highly rate both removable and fixed implant-supported prostheses. However, they rate their ability to maintain their oral hygiene significantly higher with the removable prosthesis. Both immediate provisionalization and conventional loading receive positive patient-reported outcomes. CONCLUSIONS Patient-reported outcome measures should be gathered in every clinical study in which the outcomes of oral rehabilitation with dental implants are investigated. PROMs, such as patients' satisfaction and QHRQoL, should supplement other clinical parameters in our clinical definition of success.
The Mitochondrial Thioredoxin System Contributes to the Metabolic Responses Under Drought Episodes in Arabidopsis

Thioredoxins (Trxs) modulate metabolic responses during stress conditions; however, the mechanisms governing the responses of plants subjected to multiple drought events and the role of Trxs under these conditions are not well understood. Here we explored the significance of the mitochondrial Trx system in Arabidopsis following exposure to single and repeated drought events. We analyzed the previously characterized NADPH-dependent Trx reductase A and B double mutant (ntra ntrb) and two independent mitochondrial thioredoxin o1 (trxo1) mutant lines. Following similar reductions in relative water content (∼50%), Trx mutants subjected to two drought cycles displayed a significantly higher maximum quantum efficiency (Fv/Fm) and were less sensitive to drought than their wild-type counterparts and than all genotypes subjected to a single drought event. Trx mutant plants displayed a faster recovery after two cycles of drought, as observed by the higher accumulation of secondary metabolites and higher stomatal conductance. Our results indicate that plants exposed to multiple drought cycles are able to modulate their subsequent metabolic and physiological response, suggesting the occurrence of an exquisite acclimation in stressed Arabidopsis plants. Moreover, this differential acclimation involves the participation of a set of metabolic changes as well as redox poise alteration following stress recovery.
Distal Radius Fractures in the Elderly: Use of the Volar Bearing Plate

Background Distal radius fractures represent some of the most common injuries to the upper extremity, yet current evidence demonstrates great variability in the management of this injury. Elderly patients, in particular, stand to benefit from the early mobilization provided by operative fixation with a volar bearing plate. Methods We conducted a retrospective chart review on all patients 65 years or older who underwent unilateral open reduction internal fixation of distal radius fractures using a volar bearing plate at a single institution between January 2014 and January 2016. We excluded patients with bilateral injuries, multiple fractures, and major injuries to the same extremity. Results Fifty-five patients met criteria for this study. By AO classification, we repaired 17 type A, 24 type B, and 14 type C fractures. At final radiographic measurements, average radial height compared with ulna measured −0.31 mm, average radial inclination measured 20.45 degrees, and average volar tilt measured 7.11 degrees. On discharge, 36 patients had wrist range-of-motion data consistent with a functional wrist. Four patients had limitations in the flexion/extension plane, 8 with radial-ulnar deviation, and 7 had limitations in both planes. Conclusions Distal radius fractures in the elderly may successfully be treated with a volar bearing plate. Useful strategies include supraperiosteal dissection of the radius from the pronator quadratus, use of a longer plate for stronger proximal fixation in osteoporotic bone, and regional block. This methodology allows for a safe procedure facilitating the early return of hand and wrist function.
The acquisition of English possessives by a bilingual child: Do input and usage frequency matter?

Abstract Previous research in child language shows that many aspects of language acquisition are frequency-linked. This study tests whether input or usage frequency predicts the order of acquisition and accuracy of a bilingual Greek–English child's English possessives. The child was followed longitudinally from age 2;6 to 3;11. Order of acquisition was comparable to that of same-aged monolingual children. The child's usage frequency and order of acquisition were highly correlated with input frequency, while her accuracy was not. We argue that the child's already-acquired Greek possessives facilitated acquisition of English possessives, even though the child's English input and usage frequencies were lower than in monolingual English children.