Miracle-dz/UniFAR-FTUs huggingface dataset:
Co-morbidity between major depressive disorder and anxiety disorders: shared etiology or direct causation?

Background Major depressive disorder (MDD) and anxiety disorders (ANX) are debilitating and prevalent conditions that often co-occur in adolescence and young adulthood. The leading theoretical models of their co-morbidity include the direct causation model and the shared etiology model. The present study compared these etiological models of MDD–ANX co-morbidity in a large, prospective, non-clinical sample of adolescents tracked through age 30. Method Logistic regression was used to examine cross-sectional associations between ANX and MDD at Time 1 (T1). In prospective analyses, Cox proportional hazards models were used to examine T1 predictors of subsequent disorder onset, including risk factors specific to each disorder or common to both disorders. Prospective predictive effect of a lifetime history of one disorder (e.g. MDD) on the subsequent onset of the second disorder (e.g. ANX) was then examined. This step was repeated while controlling for common risk factors. Results The findings supported relatively distinct profiles of risk between MDD and ANX depending on order of development. Whereas the shared etiology model best explained co-morbid cases in which MDD preceded ANX, direct causation was supported for co-morbid cases in which ANX preceded MDD. Conclusions Consistent with previous research, significant cross-sectional and prospective associations were found between MDD and ANX. The results of the present study suggest that different etiological models may characterize the co-morbidity between MDD and ANX based upon the temporal order of onset. Implications for classification and prevention efforts are discussed.
Network Strategy and Access to Business Finance

This article explores the significance of the nature of networks developed by entrepreneurs in accessing business finance. On the basis of qualitative data generated through case studies of Indian entrepreneurs in Information and Communication Technology industry, this article reports on the experience of entrepreneurs in accessing different types of business finance such as family funding, angel investment, venture capital and bank loan. Findings suggest that network plays an important role in facilitating access to business finance by building development of trust between entrepreneurs and investors. However, network acts as a successful facilitator only if other requirements for making a financial investment are favourable.
Discrimination in Scientific Review: A Natural Field Experiment on Blind Versus Non‐Blind Reviews

Using papers submitted to an international conference on economics held in Sweden in 2008, we analyze how gender, as well as other characteristics of the authors and reviewers, affects the grading of these papers by the reviewers. Correcting for other variables, including the country and research field, as well as the academic level of the author, we focus on the difference in grades between blind and non-blind review treatments. We find that non-blind reviewing has little effect, and there is no significant evidence of gender discrimination. Furthermore, we do not find any significant difference between the average grading by female and male reviewers.
Redefining and Containing Systemic Risk

Official definitions of systemic risk leave out the role of government officials in generating it. Policymakers’ support of creative forms of risk-taking and their proclivity for absorbing losses in crisis situations encourage opportunistic firms to foster and exploit incentive conflicts within the supervisory sector. To restore faith in the diligence, competence, and integrity of officials responsible for managing the financial safety net, reforms need to rework incentives in the government and financial sectors. The goal should be to align the incentives of private risk managers, accountants, credit-rating firms, and government supervisors with those of ordinary taxpayers. This article describes a series of complementary ways of advancing toward this goal. The most important steps would be to measure regulatory performance in terms of its effect on the loss exposures that the safety net passes through to taxpayers and to require institutions that benefit from the net to produce information that would support this effort. This entails estimating the explicit and implicit safety-net benefits individual institutions receive and issuing extended-liability securities whose prices would improve the accuracy of these estimates.
Has the importance of intangibles really grown? And if so, why?

Abstract Intangibles are ideas or knowledge about the natural (physical and biological) and socio‐cultural worlds that enable people to better accomplish their goals, both in primitive societies and in modern economies. Intangibles include basic research and technology improvements, as well as knowledge to better organise exchange and production, and over time become inextricably embedded in improved tangible assets. Accounting intangibles are legally excludable subsets of economic intangibles, which in turn are the subsets of cultural intangibles that can be used to create tradable goods or services. Because economic intangibles are cumulative, synergistic, and frequently inseparable from other tangible assets and/or economic intangibles not owned by any single entity, it is usually futile to estimate a separate accounting value for individual intangibles. However, the income that intangibles together generate provides useful inputs for equity valuation, and voluntary non‐financial disclosures could be informative for this purpose.
Cutaneous Vasculitis Update: Small Vessel Neutrophilic Vasculitis Syndromes

A broad and diverse spectrum of vasculitic syndromes exists. These syndromes affect the skin with varying levels of associated systemic manifestations, running the gamut from a self-limited, localized, cutaneous phenomenon to rapidly progressive, multiorgan disease. The majority of cases of cutaneous vasculitis will show a neutrophilic small vessel vasculitis that can be either a primary (idiopathic) disorder (eg, cutaneous leukocytoclastic angiitis) or a secondary disorder that is associated with drugs, infection (eg, streptococcal infection, viral hepatitis), or underlying disease (eg, connective tissue disease, malignancy). Biopsy is the gold standard for the diagnosis of cutaneous vasculitis and also necessary for the detection of cutaneous vascular immune complexes by direct immunofluorescence. Based on the type of vessel disrupted by inflammation (small and/or muscular), the distribution of vasculitis in the dermis and subcutis, and predominate inflammatory cell-type mediating vessel wall damage, a list of relevant differential diagnoses can be generated. This histologic information coupled with extravascular findings such as tissue eosinophilia, tissue neutrophilia, and/or granulomas, plus pathophysiologic markers such as direct immunofluorescent examination for immune complexes and serologic evaluation for antineutrophil cytoplasmic antibodies allows for more accurate diagnosis of specific vasculitic entities. Herein, we review both primary and secondary vasculitic syndromes that affect the skin and show a small vessel neutrophilic mediated vasculitis.
Tremelimumab for the treatment of malignant mesothelioma

Introduction: Tremelimumab demonstrated therapeutic activity in different malignancies, including malignant pleural mesothelioma (MPM); however, continued research could improve the therapeutic index of this agent. Areas covered: This review describes tremelimumab’s clinical efficacy, administration and safety in patients affected with MPM and reports the state of the art clinical trials of tremelimumab. A literature search using the PubMed database was conducted using the search terms tremelimumab, MPM, current therapy, immune checkpoint blockage and cytotoxic T lymphocyte-associated antigen-4. Data was also obtained from meeting abstracts and clinical trial registries. Expert opinion: The use of immunotherapy has been extended from melanoma to thoracic malignancies or lung cancer and MPM. The first clinical trials for MPM with drugs modulating immune checkpoints have been tested or are currently being tested with the first results now under critical consideration. Among these drugs, tremelimumab has been attracting attention as a potential new treatment for MPM. Nevertheless, even though clinical efficacy has been preliminarily demonstrated, the cost/benefit ratio of this drug for this neoplasm is yet to be ascertained.
Public policy and olympic success

The paper reports the results of regressions testing hypotheses concerning the medalwinning success of Olympic teams. It is found that while traditional economic and political factors are important, many inherent national characteristics such as geographical, demographic and cultural factors have a significant and pronounced impact. It is concluded that scope for public sports policy exists and the degree to which the inherent characteristics limit it are discussed.
Preventive cancer screening practices in HIV-positive patients

As patients with HIV age, they are at risk of developing non-AIDS defining malignancies. We performed a questionnaire study to evaluate colorectal and breast cancer screening among HIV-positive and HIV-negative patients seeking care from either an integrated (HIV/primary care), nonintegrated (specialized HIV), or general internal medicine clinic between August 2010 and July 2011. We performed a logistic regression to determine the odds of cancer screening. A total of 813 surveys were collected, and 762 were included in the analysis. As much as 401 were from HIV-positive patients. Patients with HIV were less likely to be current with their colorectal cancer screening (CRCS) (54.4% versus 65.0%, p=0.009); mammography rates were 24.3% versus 62.3% if done during the past year (p<0.001), and 42.0% versus 86.7% if done during the past 5 years (p<0.001). In adjusted models, the odds of colorectal cancer screening in HIV-positive patients compared to negative controls was not statistically significant (OR 0.8; 95% CI 0.5–1.3); however, HIV-positive women remained significantly less likely to be current with breast cancer screening (BCS) whether their mammogram was completed within 1 year (OR 0.1, 95% CI 0.1–0.2) or within 5 years (OR 0.1, 95% CI 0.0–0.2). Integrated care was not associated with improved screening; however, having frequent visits to a primary care physician (PCP) increased the likelihood of getting screened. BCS was lower in HIV-positive compared to HIV-negative women. Frequent visits to a PCPs improved cancer screening.
The impact of R&D teams' gender diversity on innovation outputs

Drawing from a sample of Spanish manufacturing firms, this paper examines the effect of R%D teams' gender diversity on different innovation outputs: products, services, process and organisational innovations. The paper argues that some innovations are best positioned to capitalise the benefits of gender diversity, because of the greater relevance of market insight and personal interactions. Allowing for systematic correlations among the different innovation outcomes, results indicate that, although the relationship between gender diversity and innovation outputs has always the shape of an inverted-U, gender diversity produces a greater impact on service and organisational innovation than in process innovation, while its greatest effect is on product innovation. Results also indicate that having R%D teams with diverse functional expertise has more potential than having a gender diverse R%D labour force, except for service innovation for which gender diversity is as relevant as functional diversity.
Short Sales Are Almost Instantaneously Bad News: Evidence from the Australian Stock Exchange

This paper investigates the market reaction to short sales on an intraday basis in a market setting where short sales are transparent immediately following execution. We find a mean reassessment of stock value following short sales of up to - 0.20 percent with adverse information impounded within fifteen minutes or twenty trades. Short sales executed near the end of the financial year and those related to arbitrage and hedging activities are associated with a smaller price reaction; trades near information events precipitate larger price reactions. The evidence is generally weaker for short sales executed using limit orders relative to market orders. Copyright The American Finance Association 1998.
Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews.

INTRODUCTION This study was an extension into an operational setting of previous laboratory work investigating the use of zopiclone and melatonin to facilitate early circadian sleep in transport aircrew. The previous laboratory-based study demonstrated that both melatonin and zopiclone were effective in inducing early circadian sleep without impacting on psychomotor performance after a 7-h sleep period. METHODS In a repeated measures, placebo-controlled protocol, 30 aircrew flew 3 transatlantic missions over which they took each of the 3 medications (placebo, sustained-release melatonin 2 mg, or zopiclone 5 mg) at an early body clock time (17:00) during their first stopover. They wore wrist actigraphs prior to and throughout the missions, took a single dose of their scheduled medication immediately prior to their early circadian bedtime, and completed a sleep questionnaire on arising from their medicated sleep. RESULTS The results of the actigraphic data show that relative to placebo, aircrew on melatonin and zopiclone fell asleep more quickly (melatonin: p < 0.01, zopiclone: p < 0.003), slept more (melatonin: p < 0.02, zopiclone: p < 0.005), had fewer awakenings after sleep onset (melatonin: p < 0.004, zopiclone: p < 0.01), and spent less time awake after sleep onset (melatonin: p < 0.01, zopiclone: p < 0.05). The results of the questionnaire data show that relative to placebo, aircrew on melatonin and zopiclone experienced less difficulty getting to sleep (melatonin: p < 0.0001, zopiclone: p < 0.001), had fewer awakenings (melatonin: p < 0.005, zopiclone: p < 0.001), less difficulty returning to sleep after awakening (melatonin: p < 0.0001, zopiclone: p < 0.0001), and reported a better sleep quality (melatonin: p < 0.0003, zopiclone: p < 0.0004). There were no statistically significant differences between melatonin and zopiclone in any of the actigraphic or questionnaire sleep parameters. CONCLUSIONS Melatonin and zopiclone, in the dosages we used, are equipotent facilitators of early circadian sleep during transmeridian air transport operations.
Percutaneous Osseointegrated Implant Surgery Without Skin Thinning in Children: A Retrospective Case Review

Objective To determine the follow-up status of osseointegration in children and to see if the omission of skin thinning in percutaneous osseointegrated implant surgery can be beneficial for children, 2 groups of children who underwent surgery with and without skin thinning were compared. Study Design This was a single-center, retrospective case review at a university hospital designed to assess the outcome of a new technique for percutaneous osseointegrated implantation in children. Material Thirty-four children who had undergone implantation from 2001 to 2012 were included in the study. The 2 groups were divided according to whether skin thinning was used. Methods Percutaneous osseointegrated implantation was performed in 1- or 2-step surgeries on patients under general anesthesia. Twenty-three patients were operated with traditional skin thinning and with a 5.5- mm long abutment, 10 patients were operated without thinning and with a 6-, 8.5-, or 9-mm-long abutment, and 1 patient was lost. Primary points of interest were clinical signs and symptoms of inflammation or infection at the site of skin penetration, time required for surgery, healing time, and any additional complications experienced by the patients. Results The group of children who underwent surgery without thinning and with shorter follow-up time experienced fewer complications, shorter time for surgery, minimized healing time, no numbness, and improved cosmetic appeal in comparison with the group that underwent the traditional skin thinning procedure. Conclusion The percutaneous osseointegrated implantation technique without skin thinning that has recently been implemented in adults is also beneficial for children.
Serum cytokines associated with severity and complications of kala-azar

Abstract Objectives: Recent clinical data suggest that severe kala-azar (or visceral leishmaniasis) is an exaggerated innate immune response mediated by inflammatory cytokines, leading to a systemic inflammatory syndrome similar to what is observed in malaria, sepsis and other diseases. We tested this hypothesis by measuring serum cytokines in individuals with kala-azar. Methods: We compared patients with severe kala-azar (i.e. hemorrhagic manifestations, n = 38) with patients without evidence of hemorrhage (n = 96). We conducted a detailed clinical and laboratory evaluation, measuring serum IL-1beta, IL-6, IL-8, IL-10, IL-12, interferon-gamma, and TNF-alpha, and markers of disseminated intravascular coagulation (DIC). Results: Infants had higher levels of inflammatory cytokines, while HIV-infected patients had lower concentrations of IL-10 and interferon-gamma. Higher levels of IL-6, interferon-gamma, and IL-8 were found among deceased patients. IL-8 and interferon-gamma were independently associated with bleeding. Several cytokines were associated with different signs of severe clinical and laboratory manifestations, including DIC. IL-6 was highly positively and independently associated with IL-1beta, IL-8, IL-10, and negatively associated with TNF-alpha. IL-1beta and TNF-alpha were also highly independently associated with disease severity. Conclusion: In its severe form, kala-azar, a neglected tropical disease, initiates a systemic inflammatory response that leads to DIC and other manifestations. Children may have higher risk of death due to the more intense cytokine release. The data supports the notion that IL-6 is the central cytokine that is associated with lethal disease, but interferon-gamma, IL1beta, IL-8, and TNF-alpha are also involved with disease severity. Inhibition of IL-6 is a potential target of adjuvant therapy for severe or pediatric forms of this disease.
Models of Online Social Networks

Abstract We present a deterministic model for online social networks (OSNs) based on transitivity and local knowledge in social interactions. In the iterated local transitivity (ILT) model, at each time step and for every existing node x, a new node appears that joins to the closed neighbor set of x. The ILT model provably satisfies a number of both local and global properties that have been observed in OSNs and other real-world complex networks, such as a densification power law, decreasing average distance, and higher clustering than in random graphs with the same average degree. Experimental studies of social networks demonstrate poor expansion properties as a consequence of the existence of communities with low numbers of intercommunity edges. Bounds on the spectral gap for both the adjacency and normalized Laplacian matrices are proved for graphs arising from the ILT model indicating such bad expansion properties. The cop and domination numbers are shown to remain the same as those of the graph from the initial time step G 0, and the automorphism group of G 0 is a subgroup of the automorphism group of graphs generated at all later time steps. A randomized version of the ILT model is presented that exhibits a tunable densification power-law exponent and maintains several properties of the deterministic model.
Inflammation-induced immune suppression of the fetus: a potential link between chorioamnionitis and postnatal early onset sepsis

Chorioamnionitis which results from microbial invasion of the amniotic cavity is the most frequent cause of preterm birth. Chorioamnionitis is associated with an increased risk of early-onset sepsis but the mechanisms underlying this association remain largely unknown. We hypothesize that developmental alterations of fetal organs and the immune system in the course of chorioamnionitis determine the risk of development of early onset sepsis. The purpose of this review is therefore to summarize the consequences of chorioamnionitis on fetal development and speculate how those antenatal changes might predispose to early onset sepsis.
Whither the Turn?: The Ambiguous Nature of Nonprofits' Commercial Revenue

According to popular accounts, the nonprofit sector has become increasingly commercialized in recent years. This article reviews the empirical literature on the commercialization trend and discusses why it is regarded as significant by scholars of civil society. It then provides fresh analyses of nonprofit revenue streams and concludes that, contrary to conventional wisdom, there has not been a "commercial turn," if this is to be understood as a new material reliance on earned, non-donated income by nonprofit organizations throughout the sector.
Lag-Length Selection and Tests of Granger Causality between Money and Income

ONE OF THE MOST WIDELY ACCEPrED RELATIONSHIPS IN macroeconomics is the positive relationship between the rate of growth of the money supply and the rate of growth of income. A diversity of opinion arises, however, with the attempt to identify a causal relationship between these variables. While Friedman and Schwartz (1963) initiated the empirical investigation of money/income causality, Sims (1972) made the most significant contribution to this literature with a practical application of the criterion developed by Granger (1969) for identifying a causal relationship. Since the appearance of Sims's approach, and an alternative one advanced by Sargent (1976), many researchers have applied these techniques to the investigation of the causal relationship between money and income. l With two exceptions, Hsiao (1981) and McMillin and Fackler (1984), these researchers have arbitrarily chosen the lengths of their distributed lags. The purpose of this paper is to test for Granger causality between money and income. This paper differs from previous work in that considerably more attention is focused on the effect of the lag specification on the test results. In particular, we investigate the extent to which rules of thumb, arbitrary lag specifications, and