Miracle-dz/UniFAR-FTUs huggingface dataset:
The Federal Reserve as Lender of Last Resort During the Subprime Crisis – Successful Stabilisation Without Structural Changes

This paper studies the actions of the U.S. Federal Reserve Bank (FRB) during the financial crisis from 2007-2012 rating the performance of the Federal Reserve during the crisis. The chosen scoring model approach shows that the average performance of five specific measures taken by the FRB only ranks between fair and good. Comparing Stiglitz (2010) viewpoints with those of the FRB, this paper analyses several policies and events and argues that the resulting decisions were well intentioned but that the outcome was different from expectations because of missing regulations and restrictions. Furthermore, the structure of the FRB is examined and criticized.
Player Load in Elite Netball: Match, Training, and Positional Comparisons.

CONTEXT The activity profile of competition and training in elite netball has not been comprehensively reported in the literature. PURPOSE To measure and analyze player load in elite netballers during matches and training sessions. The primary research question was, How does player load vary between playing positions in a match and between matches and training sessions? METHODS Various measures of player load were recorded in 12 elite professional netballers with a mean ± SD age of 26 ± 4.9 y and height of 183.2 ± 8.7 cm. Player load was assessed using a published method that uses accelerometry. Load was represented as total load in arbitrary units (au), playing intensity (au/min), and relative time spent in each of 4 playing intensity zones (low, low to moderate, moderate, and high). Data from 15 games and up to 17 training sessions were analyzed for each player. RESULTS Player load in matches for the goal-based positions (goal shooter, goal keeper, and goal defense) tended to be lower than the attacking and wing-based positions (goal attack, wing attack, wing defense, and center). The difference was largely due to the amount of time spent in low-intensity activity. Playing intensity of matches was greater than in training sessions; however, the total time spent in moderate- to high-intensity activities was not practically different. CONCLUSIONS Accelerometry is a valuable method of measuring player load in netball, and the present results provide new information about the activity profile of different playing positions.
Reversal of alopecia areata in a mouse model of human hair loss by daily dietary administration of a proprietary extract of North American ginseng (Panax Quinquefolius)

Tel: 514-398-6358 Fax: 514-398-5047 Decades of study on alopecia areata have concluded that the condition results from an autoimmune attack on the hair follicle growth center (anagen). In this study, we have used C3H mice, the established model of human alopecia areata. Elderly mice (18 months), almost completely alopecic, were placed on a daily conventional diet (6gm chow/mouse) for 32 weeks (8 months), into which 80mg/mouse of CVT-E002 (a proprietary extract of North American ginseng), was homogenized. These mice began to show hair re-growth after only 2 weeks, with complete hair re-growth by week 32 at which time they were euthanized. The absolute numbers (x106) of natural killer (NK) immune cells, and of non-NK immune cells (T/B lymphocytes) in mice consuming CVT-E002, were significantly more abundant (p< 0.0001) in both the spleen and bone marrow than in the corresponding organs of parallel, control-diet alopecic mice. In a second group of experiments, CVT-E002 was removed from the diet at week 32 and mice were placed on the control diet for the following 14 weeks (31⁄2 months). All these mice retained their fully re-grown coats. At that time, mice were aged 29 1⁄2 months (21⁄2 years), i.e., 8090 years of age in humans.
Improved Detection of Anterior Circulation Occlusions: The “Delayed Vessel Sign” on Multiphase CT Angiography

The authors evaluated 23 distal anterior circulation occlusions during a 2-year period. Ten M1-segment occlusions and 10 cases without a vessel occlusion were also included. There was significant improvement in the sensitivity of detection of distal anterior circulation vessel occlusions, overall confidence, and time taken to interpret with multiphase CTA compared with single-phase CTA. The delayed vessel sign is a reliable indicator of anterior circulation vessel occlusion, particularly in cases involving distal branches. BACKGROUND AND PURPOSE: Multiphase CTA, a technique to dynamically assess the vasculature in acute ischemic stroke, was primarily developed to evaluate collateral filling. We have observed that it is also useful in identifying distal anterior circulation occlusions due to delayed anterior circulation opacification on multiphase CTA, an observation we term the “delayed vessel sign. ” We aimed to determine the usefulness of this sign by comparing multiphase CTA with single-phase CTA. MATERIALS AND METHODS: All 23 distal anterior circulation occlusions during a 2-year period were included. Ten M1-segment occlusions and 10 cases without a vessel occlusion were also included. All patients had follow-up imaging confirming the diagnosis. Initially, the noncontrast CT and first phase of the multiphase CTA study for each patient were blindly evaluated (2 neuroradiologists, 2 radiology trainees) for an anterior circulation occlusion. Readers' confidence, speed, and sensitivity of detection were recorded. Readers were then educated on the “delayed vessel sign,” and each multiphase CTA study was re-examined for a vessel occlusion after at least 14 days. RESULTS: There was significant improvement in the sensitivity of detection of distal anterior circulation vessel occlusions (P < .001), overall confidence (P < .001), and time taken to interpret (P < .001) with multiphase CTA compared with single-phase CTA. Readers preferred MIP images compared with source images in >90% of cases. CONCLUSIONS: The delayed vessel sign is a reliable indicator of anterior circulation vessel occlusion, particularly in cases involving distal branches. Assessment of the later phases of multiphase CTA for the delayed vessel sign leads to a significant improvement in the speed and confidence of interpretation, compared with single-phase CTA.
Response of Memory CD8+ T Cells to Severe Acute Respiratory Syndrome (SARS) Coronavirus in Recovered SARS Patients and Healthy Individuals1

To date, the pathogenesis of severe acute respiratory syndrome (SARS) in humans is still not well understood. SARS coronavirus (SARS-CoV)-specific CTL responses, in particular their magnitude and duration of postinfection immunity, have not been extensively studied. In this study, we found that heat-inactivated SARS-CoV elicited recall CTL responses to newly identified spike protein-derived epitopes (SSp-1, S978, and S1202) in peripheral blood of all HLA-A*0201+ recovered SARS patients over 1 year postinfection. Intriguingly, heat-inactivated SARS-CoV elicited recall-like CTL responses to SSp-1 but not to S978, S1202, or dominant epitopes from several other human viruses in 5 of 36 (13.8%) HLA-A*0201+ healthy donors without any contact history with SARS-CoV. SSp-1-specific CTLs expanded from memory T cells of both recovered SARS patients, and the five exceptional healthy donors shared a differentiated effector CTL phenotype, CD45RA+CCR7−CD62L−, and expressed CCR5 and CD44. However, compared with the high avidity of SSp-1-specific CTLs derived from memory T cells of recovered SARS patients, SSp-1-specific CTLs from the five exceptional healthy donors were of low avidity, as determined by their rapid tetramer dissociation kinetics and reduced cytotoxic reactivity, IFN-γ secretion, and intracellular production of IFN-γ, TNF-α, perforin, and granzyme A. These results indicate that SARS-CoV infection induces strong and long-lasting CTL-mediated immunity in surviving SARS patients, and that cross-reactive memory T cells to SARS-CoV may exist in the T cell repertoire of a small subset of healthy individuals and can be reactivated by SARS-CoV infection.
Student perceptions on the use of new techonologies in engineering courses recorded lectures on the internet and moodle

IIT Bombay (IITB) has been transmitting some of its courses as part of its distance education initiative, coordinated by the Centre for Distance Engineering Education Programme (CDEEP). These courses are regular courses taken by IITB students, transmitted live from the classroom, which have a studio like environment with projectors, cameras and mikes. CDEEP makes videos of these recorded lectures available to IITB students. Some courses coordinated by CDEEP use a learning management system, Moodle. In this paper we investigated IITB students' perceptions of the use of the above technologies in their engineering / science courses. We found that students largely perceive the recorded videos and the interactivity provided by Moodle as being productive for their learning. Their responses towards the classroom environment were mixed, a significant problem being the lack of perceived spontaneity in the classroom.
The Safety, Persistence, and Acceptability of an Antiretroviral Microbicide Candidate UC781

Objective: To evaluate the persistence and acceptability of a minimally absorbed vaginal gel antiretroviral designed to block the acquisition of HIV. Methods: Sixty healthy women aged 18–45 participated in a phase-1 randomized placebo-controlled trial of a vaginal gel containing the nonnucleoside reverse transcriptase inhibitor UC781. Women underwent a single timed exposure ranging from 0 to 8 hours and were followed for 35 days. Safety was assessed by symptoms, physical exam, laboratory evaluation, and colposcopy. Persistence was assessed by drug levels in cervicovaginal lavage (CVL) and vaginal swab specimens. Results: The participants' mean age was 26 years; 77% were white. The most frequently reported adverse events were genitourinary; however, the placebo and UC781 arms had a similar distribution of mild and moderate genitourinary events. All colposcopic findings were superficial. Measuring systemic UC781 levels in the plasma revealed that 2 (5%) women in the UC781 gel group had detectable UC781; however, the amount was below the limits of quantification (2.5 ng/mL) in both participants. UC781 was detected in 37 of 40 CVL samples obtained 1–2 days after drug exposure and initial CVL; the median level of UC781 was 4965 pmol/mL, significantly higher than the known IC50 of 10 pmol/mL. Eighty percent of participants reported that they would use the product if it were found to be protective against HIV. Conclusion: In this population of HIV-uninfected women, the gel was well tolerated and acceptable. Active levels of drug were detected in CVL and vaginal swab specimens at 1–2 days at concentrations supporting the role for daily dosing.
Incorporation of growth factors into medical devices via biomimetic coatings

Orthopaedic and dental surgeons are fully aware of the need for implants to bond well with the surrounding living bone if long-lasting clinical success is to be achieved. For example, well-bonded hip implants have a 10 year failure rate, which is lowered fivefold if bonding is poor or absent. The techniques that are currently available to impart implant surfaces with the desired osteoconductive properties are essentially limited. To overcome the inherent difficulties, we have developed a ‘biomimetic’ coating process. By this means, implants with complex surface geometries, such as porous spinal implants, can be furnished with a bone-bonding surface. Furthermore, these coatings can be rendered osteoinductive as well as osteoconductive (by incorporating osteogenic agents). Using this facility, we have induced bone formation at an ectopic site in rats, and have accelerated osseointegration (bone bonding) at an orthotopic dental site in adult miniature pigs. Our preliminary results indicated that these osteoinductive dental implants bond with surrounding bone within one week instead of the usual three weeks. We believe that surfaces coated with biomimetic coatings into which osteogenic growth factors are incorporated hold great potential for use in clinical orthopaedics and dentistry.
Evidence databases, the Internet, and general practitioners: the New Zealand story.

AIM To determine self-reported access to and use of the Internet and the Cochrane Library by general practitioners (GPs) in New Zealand. METHODS A national cross sectional postal and fax survey of randomly selected GPs. RESULTS A total of 381 of 459 eligible GPs returned completed questionnaires (83%). The mean age of this sample was 45.7 years (SD 8.6) and average years in general practice was 15.7 years (SD 8.8 years). 74% (277) were male and 77% (289) in full-time practice. Internet access was present in 40% (95% CI 36-46%) of practices and 76% (72-81%) of GP's homes. The majority, 56% (51-61%), of GPs had used the Internet with regard to a patient. Younger GPs (<35 years old OR = 2.69, 95% CI 1.10-6.60) and male GPs (OR 1.72, 95% CI 1.02-2.90) were significantly more likely to report use of the Internet with respect to patients. 42% (95% CI 37-47%) of GPs were aware of the Cochrane Library but only 15% (11-19%) had used it. Those in group practice were more likely to be aware of the Cochrane database (adjusted OR 1.85, CI 1.09-3.12). CONCLUSIONS Internet use is prevalent among GPs. Solo practitioners, older GPs and female GPs are least likely to avail themselves of this resource. Although half of GPs knew about Cochrane, a minority used it. Access and use of evidence databases can be improved in New Zealand. Strategies to assist those least likely already to use Cochrane may help our collective efforts towards evidence based practice.
Multi-class SVM based gradient feature for banknote recognition

Banknote recognition system is the focus of different image processing and pattern recognition research. With the improvement in modern-day banking operations, automated systems for banknote recognition have become pertinent. Recognition of banknotes is a challenging task as banknotes can suffer from defects and images get distorted during acquisition, which raises the need for a robust recognition system to mitigate these flaws. This research proposes a new banknote recognition approach that classifies the principal components of the extracted Histogram of Gradient feature vectors using an efficient error correcting output code technique based on a Multi-Class Support Vector Machine. The method works on both sides of the bank note and efficiently recognize the denomination based on any side of the bill. The system was implemented using the Nigerian Naira, and for experimental evaluation, additional analysis was conducted using the US Dollar, Canadian Dollar, and Euro banknotes. Finally, the system performance was evaluated based on the recognition rate and processing time.
Left ventricular volumetry in healthy children and adolescents: comparison of two different real-time three-dimensional matrix transducers with cardiovascular magnetic resonance.

AIMS To assess the accuracy of different hardware and software settings for left ventricular (LV) volume quantification in children using real-time three-dimensional echocardiography (RT3DE). METHODS AND RESULTS The impact of different matrix transducers (IE 33, X3-1 and VIVID 7, V3) and quantification software settings [TOMTEC; contour-finding activity (tCFA) values ranging from 30 to 70 U] on the accuracy of LV indices was tested in 24 healthy children/adolescents (median = 12.6 years) and 25 paediatric patients with Tetralogy-of-Fallot (TOF) (median = 7.3 years) with abnormally shaped ventricles. RT3DE was compared with cardiovascular magnetic resonance (CMR) volumetry as reference. Best agreement (Bland-Altman analysis) was achieved using a tCFA value of 30 U. Applying the V3 device, end-diastolic volume (EDV) and end-systolic volume (ESV) were underestimated by 14.8 +/- 10.6% (mean +/- SD) and 11.2 +/- 16.3%, respectively (r = 9.42, P < 0.001 and r = 0.937, P = 0.003); with the X3-1 system 24.2 +/- 11.0 and 14.6 +/- 15.2%, respectively (r = 0.951, P < 0.001 and r = 0.912, P = 0.001). Negligible differences <1% (P = n.s.) between both transducers were detected applying a tCFA value of 70 U but with significant underestimation (EDV: approximately 35%, P < 0.001; ESV: approximately 26%, P < 0.001) compared with CMR. EDV and ESV of TOF patients were underestimated by 3.2 +/- 15.4 and 8.1 +/- 22.6%, respectively. Intra- and interobserver variability was <4%. CONCLUSION In contrast to recommendations of the manufacturer, data sets from both RT3DE transducers showed acceptable agreement to CMR for volumetric parameters only for low tCFA. Fine-tuning of software settings is mandatory to improve accuracy.
Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in “Evolution Canyon,” Israel

Substantial genetic differentiation, as great as among species, exists between populations of Drosophila melanogaster inhabiting opposite slopes of a small canyon. Previous work has shown that prezygotic sexual isolation and numerous differences in stress-related phenotypes have evolved between D. melanogaster populations in “Evolution Canyon,” Israel, in which slopes 100–400 m apart differ dramatically in aridity, solar radiation, and associated vegetation. Because the canyon's width is well within flies' dispersal capabilities, we examined genetic changes associated with local adaptation and incipient speciation in the absence of geographical isolation. Here we report remarkable genetic differentiation of microsatellites and divergence in the regulatory region of hsp70Ba which encodes the major inducible heat shock protein of Drosophila, in the two populations. Additionally, an analysis of microsatellites suggests a limited exchange of migrants and lack of recent population bottlenecks. We hypothesize that adaptation to the contrasting microclimates overwhelms gene flow and is responsible for the genetic and phenotypic divergence between the populations.
Eosinophil‐mediated killing of Haemonchus contortus larvar: effect of eosinophil activation and role of antobody, complement and interleukin‐5

Eosinophils have previously been shown to accumulate around the tissue invasive (L3) stage of sheep gastrointestinal parasites in vivo. In this study, eosinophils obtained from mammary washes of sheep, were shown to immobilize and kill H. contortus larvae in vitro in the presence of antibody specific against a defined L3 surface antigen. Eosinophils obtained from sheep primed by repeated infusion of H. contortus larvae were more effective than eosinophils obtained after a single infusion of parasite extract in Fasciola hepatica infected ewes suggesting the former were activated in vivo. The level of larval immobilization in the presence of antibody was significantly increased when complement was added to cultures containing activated eosinophils. The addition of interleukin-5 to larval cultures containing antibody and complement resulted in a significant increase in larval immobilization with unactivated eosinophils suggesting that eosinophil effector function is enhanced following priming with this cytokine. Ultrastructural analysis of the eosinophil/larvae interaction at 6 h of incubation revealed degranulation of adhering eosinophils onto the surface of larvae. By 24 h of incubation, many larvae showed signs of damage and most eosinophils had degenerated. These results suggest that eosinophil-mediated killing may be an effector mechanism for the elimination of L3 H. contortus larvae in immune sheep.
Black Focused Schools in Toronto: What do African-Canadian Parents Say?

The purpose of this study was to examine how parents of African descent understand the African-centered school concept as an alternative education to the mainstream public school in Toronto. While we cannot ignore the success stories of some Black students in the school system, the reality remains that the academic performance of some shows a downward trend. Hence, concerned educators and members of the AfricanCanadian community suggest the need for the establishment of a Black focused or African-centered school as an alternative to the mainstream public school. This will allow students to learn more effectively because they are culturally grounded and will be able to link issues of individual or group identities with what goes on at school. This qualitative research relied principally on in-depth interviews with twenty African-Canadian parents who have children in the mainstream public schools in Toronto. It assumes that parents are important stakeholders in their children‟s education so their views on problems and the need for an alternative form of schooling have significant implications for the academic performance of Black youth. The data from my study and available literature make it evident that despite the introduction of African heritage and multicultural programs and anti-racist education,
Reporting number needed to treat and absolute risk reduction in randomized controlled trials.

CONTEXT Ongoing efforts to improve the quality of reporting for randomized controlled trials (RCTs) include the Consolidated Standards of Reporting Trials (CONSORT) statement. We examined the frequency of explicit reporting of the number needed to treat (NNT) and the absolute risk reduction (ARR) in RCTs. METHODS Five frequently cited journals were investigated: Annals of Internal Medicine, BMJ, JAMA, The Lancet, and the New England Journal of Medicine. For each journal, 4 years were evaluated: 1989, 1992, 1995, and 1998. All issues of each journal for each year were reviewed manually. Eligible articles were those in which an RCT was conducted on the use of a medication showing a significant treatment effect. Elements abstracted from each eligible article were the condition investigated, event being treated or prevented, intervention, study results, and reporting methods (relative risk reduction, NNT, and ARR). RESULTS Of 359 eligible articles, NNT was reported in 8 articles. Six of the 8 studies were from 1998. Absolute risk reduction was reported in 18 articles, 10 of which were from 1998. CONCLUSIONS Despite CONSORT recommendations, few authors expressed their findings in terms of NNT or ARR. Consideration should be given to including these values in reports of RCTs.
Pulmonary airways: 3-D reconstruction from multislice CT and clinical investigation

In the framework of computer-aided diagnosis, this paper proposes a novel functionality for the computerized tomography (CT)-based investigation of the pulmonary airways. It relies on an energy-based three-dimensional (3-D) reconstruction of the bronchial tree from multislice CT acquisitions, up to the sixth- to seventh-order subdivisions. Global and local analysis of the reconstructed airways is possible by means of specific visualization modalities, respectively, the CT bronchography and the virtual bronchoscopy. The originality of the 3-D reconstruction approach consists in combining axial and radial propagation potentials to control the growth of a subset of low-order airways extracted from the CT volume by means of a robust mathematical morphology operator-the selective marking and depth constrained (SMDC) connection cost. The proposed approach proved to be robust with respect to a large spectrum of airway pathologies, including even severe stenosis (bronchial lumen obstruction/collapse). Validated by expert radiologists, examples of airway 3-D reconstructions are presented and discussed for both normal and pathological cases. They highlight the interest in considering CT bronchography and virtual bronchoscopy as complementary tools for clinical diagnosis and follow-up of airway diseases.