Miracle-dz/UniFAR-FTUs huggingface dataset:
Invasive mole and placental site trophoblastic tumor. Two entities of gestational trophoblastic disease with a common ultrasonographic appearance.

Gestational trophob1astic disease (GTD) is a proliferative disease of the trophoblast that may be manifested as a relatively benign form, hydatidiform mole (HM), or as the more malignant forms, invasive mole (IM) or choriocarcinoma (CCA). IM is defined by the presence of molar villi beyond the site of initial implantation (i.e., in the myometrium or at distant sites). Current pathologic practice recognizes three diagnostic categories of GTD: HM, CCA and placental site trophoblastic tumor (PSTT). Molar villi characterize HM; CCA and PSTT are avillous. PSTT of the uterus is the rarest form of GTD. The distinction between this tumor and CCA rests mainly on the microscopic appearance. The predominant cell in PSTT is intermediate trophoblastic cell. The cellular population is predominantly monomorphic, as opposed to the mixture of cell types in other forms of GTD. Pathologic examination combined with human chorionic gonadotropin (hCG) and human placental lactogen (hPL) assays are the cornerstone for diagnosis. We describe a case of IM and a case of PSTT, both invading the uterine wall. They share a similar ultrasonographic appearance; to the best of our knowledge this is the first sonographic description of PSTT.
In‐Home Wound Care Management Utilizing Information Technology

Chronic wounds are a major healthcare crisis, presenting challenges for home health agencies lacking specially trained staff to properly monitor and manage these wounds. Consequently, the home health industry needs to improve wound management methods and technologies to properly care for patients with chronic wounds. Saint Francis University's Center of Excellence for Remote and Medically Under-Served Areas partnered with a home health agency (University of Pittsburgh Medical Center Lee Regional Community Nursing Service) to identify a solution to this problem.
A joint experimental analysis of the dutch auction, book building and competitive ipo pricing methods

We examine the differences of three IPO pricing methods jointly: book building, employed worldwide, the Dutch clock auction, routinely cited as an alternative to book building, and the competitive IPO, a recent innovation, tested in a few offers in Europe. We employ experiments with South American subjects who are bank professionals or business students. The main result is the characterization of book building as a pricing method that mostly benefits individual investors at the expense of the issuer and the selling shareholders. The competitive IPO, on the other hand, was the method that gave the best results for the issuer and selling shareholders, at the expense of investors. The competitive IPO, however, showed more dispersion of initial returns and evidence of the "bait-and-switch" strategy, which may be disguised in book building offers but is clearly exposed in the competitive IPO. Issuers could benefit from regulation or private contracting that favor the competitive IPO if its procedure discourages "baiting-and-switching". Moving towards the competitive IPO may not be in the interest of underwriters and their clients. Moreover, this work adds on efficiency literature presenting analysis covering pricing efficiency, seller allocative efficiency and social welfare efficiency in IPOs. We find that auction is more social welfare efficient. Concerning pricing efficiency, learning seems to favor book building. Book building exhibited greater price formation stability and lower dispersion of initial returns after learning. Results also contradict the argument of Sherman and Titman (2002) that accuracy in the offer pricing leads to larger initial returns.
Expression of Neuronal Nitric Oxide Synthase in the Pancreas of the Sheep

In numerous mammals, nitric oxide (NO) influences the activity of the exocrine and endocrine pancreas. In this study, immunocytochemistry was utilized to investigate the expression of neuronal nitric oxide synthase (nNOS) in the pancreas of sheep. In double immunocytochemical staining, the co‐localization of nNOS with vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY) or substance P (SP) was studied. The presence of nNOS was confined to the intrapancreatic neurones (9.6 ± 1.3%) as well as to nerve fibres of the endocrine pancreas and intrapancreatic ganglia. nNOS‐immunoreactive (IR) neurones were round and oval in shape and predominantly (83.3 ± 2.6%) belonged to the middle‐size group (25–50 μm). Numerous, fine islets supplying nNOS‐IR nerve terminals were devoid of VIP, SP or NPY. Moderately numerous, non‐varicose nNOS‐IR nerve fibres of intrapancreatic ganglia frequently expressed VIP or NPY, but not SP; 2.2 ± 0.6% of nNOS‐IR intrapancreatic neurones displayed lack of VIP, whereas 7.5 ± 0.8% were VIP‐IR. All nNOS‐IR neurones were devoid of SP. The frequencies of nNOS‐IR/NPY‐IR and nNOS‐IR/NPY‐negative intrapancreatic neurones were 2.2 ± 0.4% and 6.1 ± 1.1%, respectively. Comparison with other mammals indicated that nitrergic innervation of the ovine pancreas is species‐determined and may be a reflection of the ruminants’ digestion specificity. The possible origin of nNOS‐IR nerve fibres and functional significance of NO in the pancreas of sheep were discussed.
Leveraging Customer Loyalty Data to Personalize the Service Experience

Most people value the highly personalized service they receive from their barber, handyman, or financial advisor. These providers get to know individual customers, and they tailor their offerings to better match specific needs. This leads to loyalty, as customers return for the personal service. Interestingly, many national and international services (including retail stores, airlines, and hotels) buy their customers’ loyalty by running loyalty programs that offer points and rewards. Loyalty programs collect information on individual customers; however, this information never gets passed on to a customer service representative, allowing them to personalize the service they provide to an individual customer. My thesis project investigates if loyalty program data can be collected and fed back to a customer-facing employee, allowing them to personalize their performance to an individual customer in a way that both provides value to customers as well as makes the employee feel they are better at performing their job. To arrive at my service design recommendations for customer-employee interactions in in-person settings, I conducted interviews as well as a large online survey to test my design concepts.
Do ligand binding and solvent exclusion alter the electrostatic character within the oxyanion hole of an enzymatic active site?

We report the site-specific incorporation of a thiocyanate vibrational probe into the active-site oxyanion hole of ketosteroid isomerase (KSI) to test the effect of hydrophobic steroid binding and solvent exclusion on the local electrostatic environment at this position. While binding of an uncharged ground state steroid analogue shifts the observed −CN vibrational frequency by +0.4 cm-1 relative to unliganded KSI, binding of an intermediate steroid analogue containing localized negative charge results in a +2.8 cm-1 shift. On the basis of a Stark tuning rate of 0.7 cm-1/(MV/cm), this shift indicates a fivefold larger change in the projection of the local electric field along the −CN bond in the presence of the charged ligand. Binding of a single ring phenolate with oxyanion charge localization equivalent to the intermediate steroid analogue but lacking distal hydrocarbon rings results in an identical −CN peak shift. We conclude that solvent exclusion and replacement by hydrophobic steroid rings negligibl.
Success factors in commercial property projects: the contractor’s perspective

Profitability is central for many companies concern. Many projects in the construction industry can be considered a success in terms of quality and time. This study investigates factors that affect profitability in commercial property projects, by taking the contractors perspective and only focusing on the profitability. Literature supports that there are four main categories that affect profitability: project related factors, external related factors, human related factors and project management related factors. Key players in the construction project are project managers and production managers, therefore we have chosen to interview people in those roles connected to 20 projects during 16 interviews. Through interviews, study visits and exercises we have made a ranking list of factors that affect profitability.
Vertical Silicon-Nanowire Formation and Gate-All-Around MOSFET

This letter presents a vertical gate-all-around silicon nanowire transistor on bulk silicon wafer utilizing fully CMOS compatible technology. High aspect ratio (up to 50: 1) vertical nanowires with diameter ~20 nm are achieved from lithography and dry-etch defined Si-pillars with subsequent oxidation. The surrounding gate length is controlled using etch back of the sacrificial oxide. N-MOS devices thus fabricated with gate length ~150 nm showed excellent transistor characteristics with large drive current (1.0 times 103 muA/mum), high Ion/Ioff ratio (~107), good subthreshold slope (~80 mV/dec) and low drain-induced barrier lowering (~10 mV/V). Along with good electrical characteristics, the use of low cost bulk wafers, and simple gate definition process steps could make this device a suitable candidate for next generation technology nodes.
Elk‐1 knock‐out mice engineered by Flp recombinase‐mediated cassette exchange

Elk‐1 is a member of the TCF subfamily of Ets proteins. TCFs interact with SRF at serum response elements (SREs) of immediate early genes (IEGs), such as c‐fos and Egr‐1, thereby mediating IEG induction upon extracellular stimulation. We previously generated an Elk‐1 null allele (Elk1‐137) in murine embryonic stem (ES) cells by homologous recombination. In Elk1‐137, the Elk‐1 gene was replaced by a Hygromycin B phosphotransferase – Thymidine Kinase (HygTk) fusion gene, flanked by two nonidentical Flp recombinase recognition (FRT) sites (Cesari et al., [2004] Mol Cell Biol, in press) to allow for the subsequent generation of alternative alleles of interest by recombinase‐mediated cassette exchange (RMCE). Elk1‐deficient mice derived from Elk‐1(137/0) ES cells are viable and do not reveal strong phenotypical abnormalities, apart from male sterility. However, the Elk‐1 locus contains the Tk cassette, which has previously been related to this defect. Therefore, in our first experiment involving the technique of Flp RMCE we chose to remove the HygTk cassette in Elk‐1(137/0) ES cells and to generate Elk‐1(RMCE16/0) and Elk‐1(RMCE16/RMCE16) mice. In so doing, we provide evidence that the sterility of Elk1(137/0) mice was not due to the absence of Elk‐1 but rather the presence of HygTk. This is the first report of mice derived from ES cells which were subjected to Flp RMCE and thus proves that RMCE is a powerful tool for the genetic engineering of previously tagged loci in the mouse genome. genesis 38:87–92, 2004. © 2004 Wiley‐Liss, Inc.
Analog Decoder Performance Degradation Due to BJTs' Parasitic Elements

This paper presents the effect of bipolar junction transistors' (BJTs) parasitic elements on the decoding performance of a BiCMOS analog decoder. The transistors' parasitic effects are taken into account to develop a more accurate behavioral model of the computing nodes. The model is applied to double-binary 0.25-mum BiCMOS analog decoders. Behavioral simulations show that the BJTs' parasitic elements deteriorate the error-correcting performance of a stand-alone a posteriori probability (APP) decoder by 0.5 dB compared with the ideal bit error rate (BER). In a turbo scheme, the loss is reduced to 0.2 dB for a BER that is smaller than 10-2. A simple solution based on an nMOS amplifier is proposed to counterbalance the dominant parasitic element. The amplifier reduces the degradation by 0.2 dB for the APP decoder. However, the turbo decoder is improved only for a BER above 10-2.
A Complex Systems Framework for Research on Leadership and Organizational Dynamics in Academic Libraries

This article provides a historiographical analysis of major leadership and organizational development theories that have shaped our thinking about how we lead and administrate academic libraries. Drawing from behavioral, cognitive, systems, and complexity theories, this article discusses major theorists and research studies appearing over the past century. A complex systems framework is then proposed for future research on leadership and organizational development surrounding change in academic libraries and professional responsibilities.
Labour turnover in the retail industry: Predicting the role of individual, organisational and environmental factors

Purpose – This paper aims to identify key variables that influence the variability of labour turnover.Design/methodology/approach – The approach used in this research is a case study of a major retailer. The key data sources are an index for local competitive and labour market factors, an annual employee survey, and internal labour turnover data for each UK unit of the retailer. The method used for analysis is stepwise regression which identifies the key relationships that predict labour turnover.Findings – The findings show that environmental factors such as local labour markets have a major influence on labour turnover. Organisational factors such as company culture and values are a significant influence. Management behaviour as seen through operational and control variables are also of importance. Individual employee variables are also important in decisions concerning turnover.Research limitations/implications – The statistical analysis accounts for 38.7 per cent of the total variance in labour turnov.
Drinking water quality assessment.

BACKGROUND Drinking water quality is the great public health concern because it is a major risk factor for high incidence of diarrheal diseases in Nepal. In the recent years, the prevalence rate of diarrhoea has been found the highest in Myagdi district. This study was carried out to assess the quality of drinking water from different natural sources, reservoirs and collection taps at Arthunge VDC of Myagdi district. METHODS A cross-sectional study was carried out using random sampling method in Arthunge VDC of Myagdi district from January to June,2010. 84 water samples representing natural sources, reservoirs and collection taps from the study area were collected. The physico-chemical and microbiological analysis was performed following standards technique set by APHA 1998 and statistical analysis was carried out using SPSS 11.5. The result was also compared with national and WHO guidelines. RESULTS Out of 84 water samples (from natural source, reservoirs and tap water) analyzed, drinking water quality parameters (except arsenic and total coliform) of all water samples was found to be within the WHO standards and national standards.15. 48% of water samples showed pH (13) higher than the WHO permissible guideline values. Similarly, 85.71% of water samples showed higher Arsenic value (72) than WHO value. Further, the statistical analysis showed no significant difference (P<0.05) of physico-chemical parameters and total coliform count of drinking water for collection taps water samples of winter (January, 2010) and summer (June, 2010). The microbiological examination of water samples revealed the presence of total coliform in 86.90% of water samples. CONCLUSIONS The results obtained from physico-chemical analysis of water samples were within national standard and WHO standards except arsenic. The study also found the coliform contamination to be the key problem with drinking water.
Characterization of the mutX gene of Streptococcus pneumoniae as a homologue of Escherichia coli mutT, and tentative definition of a catalytic domain of the dGTP pyrophosphohydroiases

We show that deletion of a gene of Streptococcus pneumoniae, which we call mutX, confers a mutator phenotype to resistance to streptomycin. Analysis of the DNA sequence changes that occurred in several streptomycin‐resistant mutants showed that mutations are unidirectional AT to CG transversions. The mutX gene is located immediately downstream of the previously identified ung gene and genetic evidence suggests that the two genes are coordinately regulated. Nucleotide sequence determination reveals that the mutX gene encodes a 17870 Da protein (154 residues) which exhibits significant homology with the MutT protein of Escherichia coli, a nucleoside tri‐phosphatase (dGTP pyrophosphohydrolase). The mutX gene complements the E coli mutT mutator phenotype when introduced on a plasmid. Site‐directed mutagenesis and analysis of nitrosoguanidine‐induced mutT mutants suggest that a small region of high homology between the two proteins (61% identity over 23 residues) is part of the catalytic site of the nucleoside triphosphatase. Computer searching for sequence homology to MutX uncovered a second E. coli protein, the product of orf17, a gene of unknown function located near the ruvC gene. The region of high homology between MutX and MutT is also conserved in this protein, which raises the interesting possibility that the orf17 gene plays some role in determining mutation rates in E. coli. Finally, a small set of proteins, including a family of virus‐encoded proteins and two evolutionarily conserved proteins encoded by an antisense transcript from the Xenopus laevis and human bFGF genes, were also found to harbour significant homology to this highly conserved region.
Treatment of systemic mast-cell disease with cladribine.

To the Editor: Cladribine (2-chlorodeoxyadenosine) is a purine nucleoside analogue with activity against various hematologic cancers.1 Because mast cells are derived from hematopoietic stem cells,2 we evaluated the therapeutic activity of cladribine in a patient with interferon alfa–resistant systemic mast-cell disease. A 57-year-old man was given a diagnosis of systemic mast-cell disease in 1975. At that time, he presented with back pain due to multiple compression fractures of the vertebrae and urticaria pigmentosa. After treatment with spinal irradiation, the course of the patient's illness was indolent, although he continued to have skin lesions. In 1994, he had an episode of .
A PROSPECTIVE RANDOMIZED TRIAL OF TACROLIMUS AND PREDNISONE VERSUS TACROLIMUS , PREDNISONE AND MYCOPHENOLATE MOFETIL IN PRIMARY ADULT LIVER TRANSPLANTATION : A SINGLE CENTER REPORT 1

Background. Tacrolimus (TAC) and mycophenolate mofetil (MMF) are currently approved immunosuppressants for prevention of rejection in liver transplantation (LTx). They have different modes of action and toxicity profiles, but the efficacy and safety of MMF in primary liver transplantation with TAC has not been determined. Methods. An Institutional Review Board-approved, open-label, single-center, prospective randomized trial was initiated to study the efficacy and toxicity of TAC and steroids (double-drug therapy (D» versus TAC, steroids, and MMF (triple-drug therapy (T» in primary adult LTx recipients. Both groups of patients were started on the same doses of TAC and steroids. Patients randomized to T also received 1 gm MMF twice a day. Results. Between August 1995 and May 1998, 350 patients were enrolled at a single center-175 in the D and 175 in the T groups. All patients were followed until
Ultrasound stimulation of types I and III collagen expression of tendon cell and upregulation of transforming growth factor β

Traumatic tendon injuries are commonly treated with ultrasound. However, previous research has not examined the molecular mechanism of this therapeutic effect on collagen synthesis of tendon cells. This study was designed to determine the effect of ultrasound on the expression of type I and type III collagen of tendon cells intrinsic to rat Achilles tendon. Whether a correlation exits between this effect and the expression of transforming growth factor β (TGF‐β), which enhances collagen synthesis, was also investigated. Tendon cells after ultrasound treatment and protein expression of types I and III collagen were determined by immunocytochemistry. The mRNA expressions of α1(I) procollagen, α1(III) procollagen, and TGF‐β were determined by reverse transcription‐polymerase chain reaction (RT‐PCR). Furthermore, the concentration of TGF‐β in conditioned medium was evaluated by enzyme‐linked immunosorbent assay (ELISA). Immunocytochemical staining revealed that ultrasound‐treated tendon cells were stained more strongly for types I and III collagen than were control cells. Upregulation of procollagen α1(I) gene, procollagen α1(III) gene, and TGF‐β at the mRNA level was confirmed by RT‐PCR. A dose‐dependent increase in the concentration of TGF‐β in conditioned medium obtained from cells treated with ultrasound was demonstrated by ELISA assay (p = 0.043). In conclusion, ultrasound stimulates the expression of type I and type III collagen in a process that is likely mediated by the upregulation of TGF‐β. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 24:1310–1316, 2006
Online Eye state recognition from EEG data using Deep architectures

In the past decade, improvements in the production of in-expensive PC equipment and software has permitted more refined real-time signal processing in BCI systems. In the literature, Deep learning concepts have not been applied to EEG data analysis in a systematic manner. This paper applies various existing Deep learning architectures and algorithms for the classification of EEG data applied to eye state detection. The deep learning based classifier systems presented in this work are comparable to the state of the art classifiers devised by Roesler and Suenderman (2013), and Cameron et al.(2015). The goal of this work is to construct a system producing accuracies comparable to Roesler's K* classifier, Cameron et al.'s (RRF+K*) classifiers and at the same time providing enough speed to be used in an online BCI framework. In order to meet the constraints, following architectures were designed: A Multi layered neural network with ReLU and drop-out, deep belief networks based unsupervised learning, drop-out masks on deep neural networks. Specifically, we compare our results with K*, RRF, (K*+RRF), ada(RJ48F) classifiers. Also an in-depth analysis of binary class features has been done using t-SNE based visualizations while fitting elliptical contours to the features. Prior research suggests that instance-based/lazy learners like the K* algorithm are likely to be too slow to be used in a BCI framework, with ada(RJ48F) model performing decently well. But our chosen deep neural network architectures produce higher classification accuracies and have lower convergence times making them even faster within the time specifications of real-time classification and control applications.
Environmental Disclosure and the Cost of Capital: Evidence from the Fukushima Nuclear Disaster

We exploit the Fukushima nuclear disaster as a source of variation in the demand for environmental information to study the economic consequences of environmental disclosure. Using a large, hand-collected sample of Japanese firms, we find that firms that issue stand-alone environmental reports incur a less severe — although economically and statistically negligible — increase in the cost of capital after the disaster than non-disclosing firms. Most important, we document that, within disclosing firms, those reporting verifiable information on their expected environmental performance experience a lower increase in the cost of capital compared to both non-disclosing firms and to firms that do not report information on their expected performance. Finally, firms react to the disaster by increasing the disclosure of forward-looking information, with a larger effect for firms with histories of forward-looking guidance. Taken together, our results help to clarify the circumstances under which the disclosure of non-financial and unregulated information affects the cost of capital.