Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics of additional primary malignancies in Korean patients with non-small cell lung cancer.

BACKGROUND Long-term cancer survival results in increasing numbers of multiple primary malignancies in one person, which represents growing clinical challenge in patients with lung cancer. This study was intended to assess the incidence rate, temporal relationship, and characteristics of additional primary malignancies (APM) in Korean patients with non-small cell lung cancer (NSCLC). MATERIALS AND METHODS We reviewed all 632 NSCLCs (313 adenocarcinomas, 276 squamous cell carcinomas, and 43 other NSCLCs) patients who underwent curative resection of NSCLC at the Dong-A University Medical Center from January 1991 to December 2009. We used the hospital information system and medical record to collect data about these patients and their tumors. In the data base, the following parameters were recorded: patient's demographics (age, gender and smoking habit), time interval between the diagnosis of the NSCLC and APM, NSCLC characteristics (date of diagnosis, histology, TNM staging, operative details, and survival) and characteristics of APM (site of tumor, date of diagnosis, histology, TNM staging, operative details, and survival). RESULTS Eighty-one (12.8%) of the 632 patients with NSCLC had APMs. Thirty-three patients (40.8%) had APM in their history [occurring earlier than six months or more before NSCLC diagnosis; prior (P) group], 18 patients (22.2%) were diagnosed with an APM synchronously [diagnosed within six months before or after NSCLC; synchronous (S) group], and the remaining 30 patients (37.0%) were diagnosed with an APM during the follow-up period [occurring six months or more after NSCLC diagnosis; metachronous (M) group]. The second primary malignancy occurred most often two to five years in both P group (39.4%) and M group (36.7%). The most frequent APM was stomach cancer (25.0%), followed by colorectal cancer (19.0%), and thyroid cancer (10.7%). Interestingly, we found difference in the incidence of APM between different NSCLC histotypes. In the adenocarcinoma group, colorectal cancer was the most frequently discovered [12 of 46 events (26.1%)], followed by thyroid cancer [9 of 46 events (19.6%)]. In the squamous cell carcinoma group, stomach cancer occurred most frequently [12 of 36 events (33.3%)]. CONCLUSIONS APMs are commonly seen in patients with NSCLC, either preceding or following its occurrence. Therefore, it is important to recognize the characteristic of NSCLC patients with APM in order to detect the second primary malignancy as early as possible and to achieve a possible cure of disease.
Pollinator‐mediated selection in a specialized pollination system: matches and mismatches across populations

Most studies on pollinator‐mediated selection have been performed in generalized rather than specialized pollination systems. This situation has impeded evaluation of the extent to which selection acts on attraction or specialized key floral traits involved in the plant‐pollinator phenotypic interphase. We studied pollinator‐mediated selection in four populations of Nierembergia linariifolia, a self‐incompatible and oil‐secreting plant pollinated exclusively by oil‐collecting bees. We evaluated whether floral traits experience variable selection among populations and whether attraction and fit traits are heterogeneously selected across populations. Populations differed in every flower trait and selection was consistently observed for corolla size and flower shape, two traits involved in the first steps of the pollination process. However, we found no selection acting on mechanical‐fit traits. The observation that selection occurred upon attraction rather than mechanical‐fit traits, suggests that plants are not currently evolving fine‐tuned morphological adaptations to local pollinators and that phenotypic matching is not necessarily an expected outcome in this specialized pollination system.
Vertical Canaliculotomy With Retrograde Expression of Concretions for the Treatment of Canaliculitis

Purpose: To evaluate the efficacy and safety of the technique of vertical canaliculotomy with retrograde expression of concretions for the treatment of canaliculitis. Methods: This is a retrospective, interventional case series. Patients who underwent vertical canaliculotomy by 1 surgeon (D.R.M.) from August 2011 to December 2013 were identified. On initial diagnosis of canaliculitis, all patients were treated with a combination antibiotic/steroid eyedrop and an oral antibiotic. The procedure was performed 1 month later and consisted of a 2-mm vertical canaliculotomy with sharp-tipped scissors followed by retrograde expression of the canalicular contents by compressing the canaliculus medial to lateral with 2 cotton-tipped applicators. All concretion specimens were sent for pathologic examination. Pre- and postoperative subjective complaints and objective findings on examination, including eyelid thickening and probing/irrigation results, were recorded. Results: Canalicular contents were readily expressed from all 8 patients who underwent the procedure. Pathologic analysis revealed Actinomyces species in 5 of 8 specimens and other Gram-negative and Gram-positive bacteria in the remaining specimens. All patients reported significant improvement in their symptoms and were patent to irrigation. Conclusions: Many reported surgical procedures for the treatment of canaliculitis involve the use of a curette, an instrument with sharp edges, that could potentially damage the lining of the canaliculus. Previous studies examining these procedures have reported canalicular stricture and dysfunction postoperatively. The current technique of vertical canaliculotomy with retrograde expression of canalicular contents described herein has been effective, limits iatrogenic trauma, and had a low incidence of postoperative complications in this series.
The multifarious effects of dispersal and gene flow on contemporary adaptation

Summary 1Dispersal and gene flow can have a variety of interacting effects on evolution. These effects can either promote or constrain adaptive divergence through either genetic or demographic routes. The relative importance of these effects is unknown because few attempts have been made to conceptually integrate and test them. 2We draw a broad distinction between situations with vs. without strong coevolutionary dynamics. This distinction is important because the adaptive peak for a given population is more mobile in the former than in the latter. This difference makes ongoing evolutionary potential more important in the presence of strong coevolutionary dynamics than in their absence. 3We advance a conceptual integration of the various effects of gene flow and dispersal on adaptive divergence. In line with other authors, but not necessarily for the same reasons, we suggest that an intermediate level of gene flow will allow the greatest adaptive divergence. 4When dispersal is quite low, we predict that an increase will have positive effects on adaptive divergence, owing to genetic/demographic rescue and ‘reinforcement. ’ The rescue effect may be more important in small populations and in homogeneous environments. The reinforcement effect may be more common in large populations and in heterogeneous environments. 5Once a certain level of dispersal is reached, we predict that a further increase may have negative effects on adaptive divergence. These effects may arise if carrying capacity is exceeded or maladaptive genes are introduced. 6Many additional effects remain to be integrated into this framework, and doing so may yield novel insights into the factors influencing evolution on ecological time-scales.
Newer aspects of the chemical structure and biological activity of bacterial endotoxins.

Gram-negative bacteria express at their surface various amphiphiles among which the lipopolysaccharides (endotoxins, O-antigens) have been studied most intensively. Lipopolysaccharides consist of a heteropolysaccharide portion (O-specific chain and core) which is responsible for the O- (and R-) antigenic properties and a covalently bound lipid component, termed lipid A, which contains the endotoxic principle of lipopolysaccharides. The detailed chemical structure of a large number of O-chains and the general architecture of the core oligosaccharide has been established. Recent analyses of the enterobacterial inner core region indicate the presence of a linear trisaccharide of alpha 2.4-linked 3-deoxy-D-manno-2-octulosonic acid (KDO) residues of which only the reducing group is believed to be located in the main core chain. This KDO residue which provides the link between the polysaccharide and the lipid A component appears to be involved in a recently detected ubiquitous immunodeterminant expressed by lipopolysaccharides of various origin. The chemical structure of enterobacterial lipid A's is now known in some detail. Lipid A of Salmonella, Escherichia coli and Proteus consists of a beta 1.6-linked D-glucosamine disaccharide which carries four (R)-3-hydroxytetradecanoyl groups in positions 2, 3, 2' and 3' and two phosphoryl residues in positions 1 and 4'. Up to three of the hydroxy fatty acids (positions 2, 2' and 3') are, at their 3-hydroxyl groups, acylated by non-hydroxylated acyl residues, and to phosphoryl groups non-acylated, nitrogen-containing residues such as 4-amino-4-deoxy-L-arabinopyranose and phosphorylethanolamine may be bound. The hydroxyl group in position 4 of the glucosamine disaccharide is free and that in position 6' serves as the attachment site for KDO (i.e. the polysaccharide component) in lipopolysaccharide. Based on this structure lipid A analogues have been chemically synthesized and analysed for endotoxic activity in vivo and in vitro. In two test systems (pyrogenicity, local Shwartzman reaction) the synthetic part structures exhibited weak or no endotoxic activity, as did a precursor of lipid A biosynthesis which is structurally identical to one of the analogues. In many other systems, however, including lethal toxicity, B-lymphocyte mitogenicity, macrophage activation, induction of cross tolerance, expression of lipid A antigenicity, the synthetic materials were of comparable activity as bacterial free lipid A. These findings support the structural proposals made for lipid A and they prove the previous hypothesis that the endotoxic principle is embedded in lipid A. (ABSTRACT TRUNCATED AT 400 WORDS)
Harmonization of the multiple‐locus variable‐number tandem repeat analysis method between Denmark and Norway for typing Salmonella Typhimurium isolates and closer examination of the VNTR loci

Aims: Harmonization and evaluation of the multiple‐locus variable‐number tandem repeat analysis (MLVA) method for sub‐typing Salmonella enterica ssp. enterica serovar Typhimurium (Salm. Typhimurium) in Denmark and Norway, and analysis of the typing data.
Cholinergic innervation of the amygdaloid complex in the human brain and its alterations in old age and Alzheimer's disease

The cholinergic innervation of the human amygdaloid complex was studied immunohistochemically with a choline acetyltransferase (ChAT) antibody in eight brains: five control and three with Alzheimer's disease (AD). All amygdaloid nuclei displayed ChAT‐immunopositive axons and varicosities. The density of these axons reached levels that were higher than in any other part of the forebrain except for the striatum. The highest level of ChAT‐immunopositive profiles was seen in the basolateral nucleus and the second highest in the lateral part of the central nucleus. The basomedial, accessory basal, and cortical nuclei, the amygdalohippocampal and cortico‐amygdaloid transition areas, as well as the anterior amygdaloid area, showed a moderate density of ChAT‐positive varicosities and fibers. The lateral nucleus displayed a relatively low density of cholinergic innervation, and there were only rare ChAT‐positive fibers in the medial nucleus. Although the level of cholinergic innervation in the lateral nucleus was relatively lower than in many of the other amygdaloid nuclei, it was approximately equivalent to that of entorhinal cortex, a region that receives one of the heaviest cholinergic inputs in the cerebral cortex. The distribution of the cholinergic fibers as studied by ChAT immunohistochemistry was nearly identical to that observed with AChE histochemistry. Quantitative densitometry in control specimens showed that there was no decline of amygdaloid cholinergic input when middle‐aged subjects were compared with senescent subjects. In AD there was a severe and regionally selective depletion of this innervation in the amygdaloid complex. The cortical, accessory basal, and lateral nuclei displayed the most severe loss of ChAT‐positive profiles, whereas the basolateral, and especially the central, nuclei displayed relatively little change. There was no consistent relationship between the loss of cholinergic fibers and the density of amyloid plaques and neurofibrillary tangles in amygdaloid nuclei. © 1993 Wiley‐Liss, Inc.
Comparisons of the Peritoneal Equilibration Test and Ultrafiltration in Patients with and without Diabetes Mellitus on Continuous Ambulatory Peritoneal Dialysis

Background/Aims: To compare dialysance and ultrafiltration (UF) of peritoneum in diabetes mellitus (DM) and non-DM patients on continuous ambulatory peritoneal dialysis. Methods: A total of 162 adult patients on continuous ambulatory peritoneal dialysis (40 DM and 122 non-DM patients) were studied with the peritoneal equilibration test (PET) using 2.5% glucose dialysis solution retained for 4 h. Patients using 2,000 or 1,500 ml of infusion volume were classified into groups A (23 DM and 63 non-DM patients) and B (16 DM and 41 non-DM patients), respectively. PET results were compared between DM and non-DM patients by unpaired t test. Using Pearson’s correlation and least-square multiple regression, the most powerful predictors of UF rate were also evaluated in DM and non-DM patients. Results: There were no differences between PET parameters and UF rate between DM and non-DM patients in the whole group (WG) and group A. The only significant difference (p < 0.05) was an increased D4/D0 value in DM patients in group B. The most simple but powerful method to predict UF rate was (100 – GAP)/(D4/D0), where GAP corresponds to the glucose absorption percentage and D4/D0 is the PET 4-hour dialysate glucose level/PET 0-hour dialysate glucose level. GAP and D4/D0 were two major determinants of UF rate in the DM group, non-DM group and WG. Conclusions: Peritoneal permeability did not differ between DM and non-DM patients, and GAP and D4/D0 were two major factors predicting UF rate.
Long-Term Pulmonary Histopathologic Changes in Rats Following Acute Experimental Exposure to Chlorine Gas

In this study, we aimed to investigate the long-term histopathologic changes in the lungs of rats exposed to a high concentration of chlorine gas. Twenty-four Sprague-Dawley rats were divided into three groups: the control group (group I) (n = 8), early-examined group (group II) (n = 8), and late-examined group (group III) (n = 8). In group II the lungs of rats were taken out just after the exposure, whereas in group III the lungs were taken out 45 days after the exposure. Eosinophilic liquid accumulation in alveoli and bronchi, diffuse intraalveolar edema, vascular congestion, severe perivascular edema, and free bleeding in intraalveolar and interstitial area were observed in the lungs of rats in group II. Interstitial fibrosis and thickening of the alveolar septa were observed in group III. These findings suggest that the people using these cleaning agents are at risk of harming themselves, and the victims of chlorine gas injury should be reexamined at a later period since they may have pulmonary damage even after 45 days of exposure.
Knowledge of mental health benefits and preferences for type of mental health providers among the general public.

OBJECTIVE The study explored knowledge of mental health benefits and preferences for providers among the general public. METHODS Analysis was based on a telephone survey of 1,358 adults randomly sampled throughout Michigan in 1997-1998. RESULTS A large proportion of the respondents were uninformed about their mental health benefits. One-quarter of the sample were unsure if their health plan even included mental health services. Forty-three percent of the sample believed that mental health benefits were equal to benefits provided for general medical services. In answer to a survey question that summarized payment restrictions for psychiatric services and counseling under Medicare, nearly a quarter of older respondents indicated that they would not seek care even when needed. In the overall sample, the majority of respondents said they would initially seek care from their primary care physician for a mental health problem, although responses varied by age. Persons over age 65 were significantly more likely to seek assistance from their primary care doctor than were younger persons. CONCLUSIONS The general public lacks information about important mental health benefits, and this lack of information may represent a barrier in their seeking care when needed. Given the overriding preference for primary care providers to treat mental health problems, particularly among older adults, mental health issues should be given more attention at all levels of primary care education.
Secure Steganography Technique Based on Bitplane Indexes

This paper is concerned with secret hiding in multiple image bitplanes for increased security without undermining capacity. A secure steganographic algorithm based on bitplanes index manipulation is proposed. The index manipulation is confined to the first two Least Significant Bits of the cover image. The proposed algorithm has the property of un-detect ability with respect to stego quality and payload capacity. Experimental results demonstrate that the proposed technique is secure against statistical attacks such as pair of value (PoV), Weighted Stego steganalyser (WS), and Multi Bitplane Weighted Stego steganalyser (MLSB-WS).
Psychological reactions to edentulousness and treatment with jawbone‐anchored bridges

ABSTRACT– Total edentulousness can lead to chewing problems as well as to feelings of insecurity and inferiority and considerable psycho‐social problems. For many people a conventional removable denture is unsatisfactory. A new method ‐ osseointegration ‐ involves a titanium screw being operated into the jawbone and the attachment pre‐ and postoperativelv 3 monts and then 2 years after the insertion pre‐ and postoperatively 3 months and then 2 years after the insertion of a jawbone‐anchored bridge.
Orally Administered Lactoferrin Exerts an Antimetastatic Effect and Enhances Production of IL-18 in the Intestinal Epithelium

The effects of oral administration of bovine lactoferrin (bLF) and its hydrolysate on the lung colonization by colon 26 carcinoma were investigated. At doses of 100 or 300 mg/kg/day for seven successive days, bLFs demonstrated a significant inhibitory effect on experimental metastasis, which indicated effectiveness before and after tumor implantation. Oral administration of bLFs augmented CD4+, CD8+, and asialoGM1+ cells in the spleen and peripheral blood. Their cytotoxic activities against Yac-1 and colon 26 carcinoma were enhanced by bLF. In the small intestinal epithelium, CD4+ and CD8+ cells were markedly increased, and, simultaneously, enhanced production of interleukin-18 (IL-18) was confirmed in the intestinal epithelial cells. In this model, intravenous injection of murine IL-18 showed significant inhibition of the lung colonization by colon 26 carcinoma. These results suggested that inhibition of experimental metastasis by oral administration of bLF and pepsin hydrolysate of bLF might be due to enhanced cellular immunity, presumably mediated by enhanced IL-18 production in the intestinal epithelium.
Effect of Intravenous Ondansetron on Sensory and Motor Block after Spinal Anaesthesia with Hyperbaric Bupivacaine

Ondansetron is a potent antiemetic and a competitive antagonist at serotonin receptors, which are also involved in modulation of pain. This study was designed to assess the effect of systemic ondansetron on sensory and motor block after subarachnoid anaesthesia with hyperbaric bupivacaine. Sixty patients undergoing transurethral resection of bladder tumours were randomly assigned to one of two groups. Group 1 received 2 ml (4 mg) of ondansetron whereas patients in group 2 received 2 ml of normal saline 15 minutes prior to administration of subarachnoid block with 2.5 ml of hyperbaric bupivacaine 0.5%. Time to attain peak sensory block (P=0.27), time to two segment regression (P=0.19) and time to regression to the S2 dermatome (P=0.84) did not significantly differ between the two groups. No differences in regression of sensory block were noted at any time. The mean duration of motor block also did not differ (P=0.44), with similar regression of block at all time intervals except at 90 minutes. We concluded that intravenous ondansetron does not affect the intensity or duration of sensory and motor block after spinal anaesthesia with hyperbaric bupivacaine.
Conflict between diabetes guidelines and experienced counselling in sports and physical activity. An exploratory study

According to medical guidelines counselling on sports and physical activity should be part of diabetes treatment. Using an online questionnaire (n = 181), we explored how people with both type 1 and type 2 diabetes experienced this counselling in the Netherlands. Most respondents were critical, indicating that they did not receive proper guidance or helpful advices. A third of the respondents mentioned that there was hardly any attention for the subject during their treatment. This conflict between guidelines and experiences point towards the need for more insight in critical issues in counselling regarding taking up sports and physical activity (again) after diagnosis.
3D/Inkjet-printed millimeter wave components and interconnects for communication and sensing

This paper presents the design and experimental results of 3D/inkjet printed circuits operating in millimeter wave frequencies. Millimeter wave technology is particularly suitable for 5G communication systems however it is also associated with a higher cost, and larger time-to-market. 3D/inkjet printing technology presents an exciting alternative to traditional fabrication techniques being cost-efficient, and allowing for rapid prototyping. This paper offers an overview of recent results associated with fully printed planar antennas, lens antennas, millimeter wave interconnects and sensors demonstrating the potential of the technology.
Intercomparison of Methods for Calculating Potential Evaporation in Regional and Global Water Balance Models

Five methods (Thornthwaite, Hamon, Jensen-Haise, Turc, and Penman) for estimating potential evaporation for a reference surface (PEr) were compared to four methods (Priestley-Taylor, McNaughton-Black, Penman-Monteith, and Shuttleworth-Wallace) for estimating surface-dependent potential evaporation (PEs) using three cover types at each of seven locations from Fairbanks, Alaska, to San Juan, Puerto Rico. For annual PE the PEs methods generally agreed with the PEr methods, but for many locations, differences among methods were hundreds of millimeters per year. No methods were consistently low or high. Three of the PEs methods depend strongly on maximum leaf conductance, for which Korner [1994] provided satisfactory values by cover type. Potential interception ∥PEi∥ can only be estimated appropriately for all cover types by the Shuttleworth-Wallace method. Use of 5-day or monthly input data did not greatly degrade results, so use of monthly data to generate PE estimates appears warranted in global water balance models.