Miracle-dz/UniFAR-FTUs huggingface dataset:
The dilemma of success: Percutaneous coronary interventions in patients ≥ 75 years of age—successful but associated with higher vascular complications and cardiac mortality

Elderly patients are increasingly referred to percutaneous coronary interventions (PCIs). Recent reports suggest complications rates are declining in the elderly. We sought to determine whether procedural and in‐hospital outcomes are different in patients aged ≥ 75 years undergoing nonemergent PCI as compared to patients age < 75 years. The outcome of 266 consecutive patients age ≥ 75 years undergoing nonemergent PCI was compared to that of 1,681 consecutive patients age < 75 years. Compared with younger patients, greater proportions of elderly patients were women and had a history of hypertension, peripheral vascular disease, and cerebral vascular events. Elderly patients had more extensive coronary involvement. Procedural success was similar in both groups (94%). The in‐hospital cardiac death rate was significantly higher in the elderly patients (2.3% vs. 0.7%; P = 0.03). Aged patients also had a significantly higher incidence of vascular and bleeding complications. Blood transfusion was required more often in the elderly group (4.5% vs. 2.6%; P = 0.07). The hospitalization length was significantly higher in the elderly group (4.1 ± 6.0 vs. 2.5 ± 4.3 day; P = 0.0004). By multivariate logistic regression (adjusted for baseline clinical and angiographic variables), age ≥ 75 years was found to be an independent predictor of in‐hospital cardiac death (odds ratio = 3.9; 95% CI = 1.3–11.5; P = 0.015). Although PCI is technically successful in patients aged ≥ 75 years; it is associated with more acute cardiac and vascular complications and higher in‐hospital cardiac mortality. Cathet Cardiovasc Intervent 2003;59:195–199. © 2003 Wiley‐Liss, Inc.
Health Professions Education: A Bridge to Quality

The Institute of Medicine study Crossing the Quality Chasm (2001) recommended that an interdisciplinary summit be held to further reform of health professions education in order to enhance quality and patient safety. Health Professions Education: A Bridge to Quality is the follow up to that summit, held in June 2002, where 150 participants across disciplines and occupations developed ideas about how to integrate a core set of competencies into health professions education. These core competencies include patient-centered care, interdisciplinary teams, evidence-based practice, quality improvement, and informatics. This book recommends a mix of approaches to health education improvement, including those related to oversight processes, the training environment, research, public reporting, and leadership. Educators, administrators, and health professionals can use this book to help achieve an approach to education that better prepares clinicians to meet both the needs of patients and the requirements of a changing health care system.
Enzymatic correlates of energy status in wild yellow perch inhabiting clean and contaminated environments

Enzymes representing a variety of metabolic pathways were examined in yellow perch (Perca flavescens) collected from a metal‐contaminated region (Rouyn‐Noranda, Québec, Canada) to determine which were most closely related to fish condition factor, pyloric caeca weight, and visceral lipid accumulation, as well to seek a better understanding of the influence of metal contamination on the physiology and biometrics of perch. Compared to laboratory fish, wild perch were under important energy restrictions. The condition factor of wild fish was correlated with indicators of aerobic metabolism (citrate synthase, cytochrome C oxidase), protein anabolism (nucleoside diphosphokinase), and indicators of lipid accumulation (glucose‐6‐phosphate dehydrogenase, visceral lipid index). Pyloric caeca weights were well correlated with indicators of protein anabolism, but only when both seasons were examined together, possibly indicating a lag in the response of enzymes to changes in diet. The addition of contaminant stress to existing energy restrictions led to changes in the relationships between enzymes and biometrics, reducing the predictive power of the models for perch in contaminated lakes. The present study broadens our knowledge of the impact of metal contamination on energy accumulation and tissue metabolic capacities in wild perch. Environ. Toxicol. Chem. 2011;30:2148–2156. © 2011 SETAC
Effect of Prenatal Exposure to Isoflavones on Bone Metabolism in Mice at Adulthood

Early postnatal exposure to genistein resulted in improved bone health at early adulthood in mice. The objective of the present study was to determine whether in utero exposure to isoflavones also has a positive effect on bone health, resulting in higher bone mineral density (BMD) and greater resistance to fracture at adulthood. Pregnant mice received daily subcutaneous injections of genistein (3.75 mg), daidzein (3.75 mg), genistein (3.75 mg) + daidzein (3.75 mg), or vehicle from d 9 to 21 of pregnancy. At birth, offspring (n = 12/group/gender) remained with their respective mother and were weaned at postnatal age of 21 d and fed control diet, devoid of isoflavones, until 4 mo of age, at which time tissues were collected. There was an overall effect of treatment on femur BMD, which was higher (p < 0.001) among control and genistein groups compared with daidzein and genistein + daidzein groups. Treatment did not have a significant effect on femur peak load. Among females, daidzein resulted in a lower (p = 0.02) BMD of lumbar vertebra (LV) 1–4 than all other groups however peak load of LV4 did not differ due to treatment or gender. In conclusion, in utero exposure to isoflavones did not result in functional benefits to bone at young adulthood.
Invasion of bovine epithelial cells by verocytotoxin‐producing Escherichia coli O157: H7

The ability of verocytotoxin‐producing Escherichia coli (VTEC) O157: H7 to enter selected human (RPMI‐4788 and HeLa) and bovine (MAC‐T, mammary secretory; MDBK, kidney) epithelial cell lines was evaluated. All VTEC evaluated efficiently entered RPMI‐4788 and MAC‐T cell lines. VTEC entered MDBK cells at approximately 4% of MAC‐T cells. VTEC were not able to invade HeLa cells. Presence of plasmid had no influence on efficiency of entry, nor did production of shiga‐like toxin (SLT I or SLT II). Internalization required microfilaments, but not microtubules. Two types of adherence, localized and diffuse, were exhibited depending on isolate and cell line evaluated. Ability of VTEC to invade bovine mammary epithelial cells may be important in pathogenesis in the bovine, may indicate a route by which raw milk may potentially become contaminated, and may provide a reservoir of bacteria for the contamination of workers, equipment and carcass at time of slaughter.
Predicting season ticket holder loyalty using geographical information

ABSTRACT Season ticket holders (STHs) are an integral part of the sporting product. Interestingly, and contrary to the persistent interest in analysing the determinants of stadium attendances, sports economists have so far largely refrained from exploring the potential determinants of STH loyalty as expressed through regular stadium attendances. In this article, we address this notable shortcoming by exploring the potential determinants of STH stadium attendance demand. In particular, we examine the yet under-researched role of increasing opportunity costs resulting from larger home-stadium distances in STH stadium attendance demand. Our results suggest that STHs’ geographical location plays an important role in predicting STH stadium attendance demand. More specifically, we observe an unexpected, nonlinear distance–attendance relationship, indicating that behaviourally loyal STHs live either exceptionally close or far away from the stadium.
Traditional and new prognosticators in breast cancer: Nottingham index, Mib-1 and estrogen receptor signaling remain the best predictors of relapse and survival in a series of 289 cases

Histopathological and immunohistochemical findings on tissue microarrays, overall survival (OS), disease-free survival (DFS) and incidence of relapses (R) were recorded and statistically analyzed in 289 breast cancers. A higher R and a shorter DFS were significantly related to larger tumors, lymph node invasion, higher tumor grade, absence of estrogen receptors (ER), triple negative tumors, and presence of lymphovascular invasion (LVI). Longer OS was observed to be significantly associated with smaller tumor size (T), lymph node negativity, lower tumor grade, absence of LVI, lower Mib-1 expression and with the presence of ER. At multivariate analysis, only T for DFS and lymph node status and triple negativity either for DFS or OS had independent prognostic value. In the 194 lymph node-negative women DFS and OS were inversely related to tumor grade, absence of ER, Mib-1 expression in more than 15% of neoplastic cells and, only for DFS, presence of LVI. In the 95 lymph node-positive the number of involved nodes was the most discriminating parameter either for DFS or OS; T, Her-2 status and presence of LVI were significantly related to DFS. ER negativity was related to higher grade, progesterone receptors (PR) negativity, Her-2 negativity, hence to triple negativity, to basal-like type, Mib-1expression over 15% of neoplastic cells. Her-2 positivity was related to higher grade, ER positivity and PR positivity. Basal-like type was not an independent prognosticator, while triple negative type has a significant relation to shorter OS. The Nottingham prognostic index accurately identifies prognostic groupings and Mib-1 expression and ER signaling are the key biological predictors even in single cases.
Advice Goes Virtual: How New Digital Investment Services are Changing the Wealth Management Landscape

The emergence of a new group of digital wealth management firms offering automated investment advice services has quickly become one of the most frequently debated topics in the industry. Comparisons are being made to the travel industry of the 1990s, when the travel agent model lost ground to online services such as Expedia, and some media outlets and analysts are predicting that the emerging start-ups will revolutionize how wealth management advice is provided. Yet others have discounted and labeled this “robo-advisor” movement as unproven and believe its solutions are no match for human personalized investment advice. In this context, we wanted to explore these new firms to understand the innovations they are offering and their aspirations for the future and answer some of the questions many in the industry are asking. Are these firms going to challenge the traditional wealth management model and change the industry landscape? Is there a large enough market for their services beyond the young, tech- savvy client segment they have attracted so far? And, if the underlying changes (e.g., client experience, new potential client segments) are permanent, what should traditional firms do? This report presents our insights and perspectives based on numerous interviews and discussions with senior executives across the industry, including traditional wealth managers and digital entrants, as well as secondary market research. Our key findings are as follows: digital entrants use a combination of simplified client experience, lower fees and increased transparency to offer automated advice direct to consumers; the new models have the potential to make advice for the mass market feasible at last; the changes digital firms have introduced are here to stay, so traditional players need to determine if and how they want to approach them. In summary, our view is that the emergence of digital entrants into the wealth management space will indeed change the industry in several ways. This will ultimately benefit new and existing investors alike by providing better and more affordable products and services through an improved client experience.
Effects of Resisted Sprint Training on Acceleration in Professional Rugby Union Players

Abstract West, DJ, Cunningham, DJ, Bracken, RM, Bevan, HR, Crewther, BT, Cook, CJ, and Kilduff, LP. Effects of resisted sprint training on acceleration in professional rugby union players. J Strength Cond Res 27(4): 1014–1018, 2013—The use of weighted sled towing as a training tool to improve athlete acceleration has received considerable attention; however, its effectiveness for developing acceleration is equivocal. This study compared the effects of combined weighted sled towing and sprint training against traditional sprint training on 10 and 30 m speed in professional rugby union players (n = 20). After baseline testing of 10 and 30 m speed, participants were assigned to either the combined sled towing and sprint training (SLED) or traditional sprint training (TRAD) groups, matched for 10-m sprint times. Each group completed 2 training sessions per week for 6 weeks, with performance reassessed post-training. Both training programmes improved participants' 10 and 30 m speed (p < 0.001), but the performance changes (from pre to post) in 10 m (SLED −0.04 ± 0.01 vs. TRAD −0.02 ± 0.01 seconds; p < 0.001) and 30 m (SLED −0.10 ± 0.03 vs. TRAD −0.05 ± 0.03 seconds; p = 0.003) sprint times were significantly greater in the SLED training group. Similarly, the percent change within the SLED group for the 10 m (SLED −2.43 ± 0.67 vs. TRAD −1.06 ± 0.80 seconds; p = 0.003) and 30 m (SLED −2.46 ± 0.63 vs. TRAD −1.15 ± 0.72 seconds; p = 0.003) tests were greater than the TRAD group. In conclusion, sprint training alone or combined with weighted sled towing can improve 10 and 30 m sprint times; however, the latter training method promoted greater improvements in a group of professional rugby players.
Current status of cataract blindness and Vision 2020: The right to sight initiative in India

Background: India is a signatory to the World Health Organization resolution on Vision 2020: The right to sight. Efforts of all stakeholders have resulted in increased number of cataract surgeries performed in India, but the impact of these efforts on the elimination of avoidable blindness is unknown. Aims: Projection of performance of cataract surgery over the next 15 years to determine whether India is likely to eliminate cataract blindness by 2020. Materials and Methods: Data from three national level blindness surveys in India over three decades, and projected age-specific population till 2020 from US Census Bureau were used to develop a model to predict the magnitude of cataract blindness and impact of Vision 2020: the right to sight initiatives. Results: Using age-specific data for those aged 50+ years it was observed that prevalence of blindness at different age cohorts (above 50 years) reduced over three decades with a peak in 1989. Projections show that among those aged 50+ years, the quantum of cataract surgery would double (3.38 million in 2001 to 7.63 million in 2020) and cataract surgical rate would increase from 24025/million 50+ in 2001 to 27817/million 50+ in 2020. Though the prevalence of cataract blindness would decrease, the absolute number of cataract blind would increase from 7.75 million in 2001 to 8.25 million in 2020 due to a substantial increase in the population above 50 years in India over this period. Conclusions: Considering existing prevalence and projected incidence of cataract blindness over the period 2001-2020, visual outcomes after cataract surgery and sight restoration rate, elimination of cataract blindness may not be achieved by 2020 in India.
In vivo vitiligo induction and therapy model: double‐blind, randomized clinical trial

In this study, we developed an in vivo vitiligo induction model to explore the underlying mechanisms leading to Koebner’s phenomenon and to evaluate the efficacy of therapeutic strategies. The model consisted of 12 pigmented test regions on the back of generalized vitiligo patients that were exposed to three Koebner induction methods: cryotherapy, 755 nm laser therapy, and epidermal abrasion. In addition, four cream treatments (pimecrolimus, tacrolimus, steroid and placebo) were randomly applied. Koebnerization was efficiently induced by all three induction methods. In general, cryotherapy was the best method of Koebner induction, followed by 755 nm laser therapy and epidermal abrasion. Reproducible results were obtained, which showed enhanced depigmented surface areas and higher amounts of T lymphocytes in placebo‐treated test zones compared to active treated areas. Tacrolimus and local steroids were better inhibitors of Koebner’s process (P < 0.05) compared to pimecrolimus. Our in vivo vitiligo induction model is very informative to investigate vitiligo induction and to determine the efficacy of topical treatments in vitiligo. This proof of concept confirms the efficient comparison of head‐to‐head therapeutic strategies intra‐individually in a standardized, specific and better timed way.
Half a World Apart? Overlap in Nonbreeding Distributions of Atlantic and Indian Ocean Thin-Billed Prions

Distant populations of animals may share their non-breeding grounds or migrate to distinct areas, and this may have important consequences for population differentiation and dynamics. Small burrow-nesting seabirds provide a suitable case study, as they are often restricted to safe breeding sites on islands, resulting in a patchy breeding distribution. For example, Thin-billed prions Pachyptila belcheri have two major breeding colonies more than 8,000 km apart, on the Falkland Islands in the south-western Atlantic and in the Kerguelen Archipelago in the Indian Ocean. We used geolocators and stable isotopes to compare at-sea movements and trophic levels of these two populations during their non-breeding season, and applied ecological niche models to compare environmental conditions in the habitat. Over three winters, birds breeding in the Atlantic showed a high consistency in their migration routes. Most individuals migrated more than 3000 km eastwards, while very few remained over the Patagonian Shelf. In contrast, all Indian Ocean birds migrated westwards, resulting in an overlapping nonbreeding area in the eastern Atlantic sector of the Southern Ocean. Geolocators and isotopic signature of feathers indicated that prions from the Falklands moulted at slightly higher latitudes than those from Kerguelen Islands. All birds fed on low trophic level prey, most probably crustaceans. The phenology differed notably between the two populations. Falkland birds returned to the Patagonian Shelf after 2-3 months, while Kerguelen birds remained in the nonbreeding area for seven months, before returning to nesting grounds highly synchronously and at high speed. Habitat models identified sea surface temperature and chlorophyll a concentration as important environmental parameters. In summary, we show that even though the two very distant populations migrate to roughly the same area to moult, they have distinct wintering strategies: They had significantly different realized niches and timing which may contribute to spatial niche partitioning.
[Modulation by the hypocretinergic/orexinergic neurotransmission system in sleep-wakefulness cycle states].

INTRODUCTION The hypocretins/orexins are neuropeptides synthesized by a small neuronal cell group located in the posterior and lateral hypothalamus. These peptides have been considered modulators of the sleep-wakefulness cycle since their discovery in 1998; the hypocretinergic/orexinergic system is very active during wakefulness. In addition, the absence of either these peptides or their receptors is associated to narcolepsy-cataplexy, a disease in which the sleep-wakefulness cycle is completely disorganized. DEVELOPMENT Hypocretinergic/orexinergic neurons directly activate the cerebral cortex and neuronal cell groups of the reticular activating system containing noradrenaline, serotonin, dopamine, acetylcholine and histamine, through which they may also indirectly activate the cerebral cortex and enhance wakefulness; as well, these neurons inhibit REM sleep generation in the ventral pontine tegmentum. The decrease in the activity of hypocretinergic/orexinergic neurons during sleep inhibits the aminergic and cholinergic neurons of the reticular activating core, decreasing cortical activation and renewing REM sleep generation in the ventral pontine tegmentum. CONCLUSIONS Hypocretins/orexins modulate wakefulness and EEG activation in part through their actions on reticular core neurons projecting to the cortex and suppress REM sleep generation through inhibition of ventral pontine tegmentum neurons within the ventral oral pontine tegmentum. The hypoactivity of this system supports the sleep cycle fragmentation and general disorganization appearing in narcolepsy, as well as momentary interruption of wakefulness by REM sleep episodes.
A systematic review of lean implementation approaches: a proposed technology combined lean implementation framework

Nowadays, lean implementation seems to be very effective when combined with technologies like radio frequency identification (RFID) but a gap has been observed regarding the availability of certain lean implementation approaches that practice this confluence. Keeping this requirement in view, an extensive systematic literature study has been conducted to first confirm this gap and then to propose an implementation approach by selecting the right approach, methodologies, tools and steps from previous literature. In order to achieve this task, 39 most relevant previous lean implementation approaches have been selected through rigorous search and selection (based on studying their originality, methodology, objectives and limitations) which first confirmed the gap and then enlighten that 56% of previous implementation approaches have utilised ‘implementation framework’ as the most common approach and the common methodologies utilised were case study and literature review. Moreover, about 25.6% of previous approaches have utilised Value Stream Mapping (VSM) for lean implementation and Technology-Organisation-Environment (TOE) framework was considered as the most appropriate methodology for RFID deployment. So, these statistics were further utilised to invent an implementation framework comprising 21 steps and four implementation phases in which confluence of VSM and TOE has been effectively utilised to achieve successful deployment of technology combined lean.
Motivational Factors in the Acquisition of Welsh in Poland

Abstract For some years now, Welsh has been taught as a foreign language outside Wales, most especially in other Celtic countries, central Europe – and Poland. The first courses were established in the Catholic University of Lublin in the 1980s, and this provision has expanded over the years to include a Celtic language specialisation within the Faculty of English at Adam Mickiewicz University in Poznań. Relying at first on teachers from Wales to provide instruction in Welsh, the Centre for Celtic Studies is increasingly producing new, competent speakers/users of Welsh among the Poles. An obvious question to be asked concerns motivational issues – why, on the eastern edges of the European Union, are there people willing to put the effort into learning a language from the far west of Europe, when they have, in some cases, little contact with regular users of Welsh? Through the use of focus group interviews, the present study attempts to discover what motivates Polish students to study Welsh in a context of limited direct contact with the speakers of the language and limited, indirect access to Welsh language and culture.