Miracle-dz/UniFAR-FTUs huggingface dataset:
Melanotic Neuroectodermal Tumor of Infancy.

CONTEXT. — Melanotic neuroectodermal tumor of infancy, albeit rare and generally regarded as benign, is an important tumor to recognize because of its rapid growth, potential for local recurrence, and small round blue cell morphology, which can lead to misdiagnosis of a malignant neoplasm. OBJECTIVE. — To review its clinical presentation and immunomorphologic findings, and discuss common entities in the differential diagnosis. DATA SOURCES. — The study involved PubMed searches, including multiple review articles, case studies, retrospective studies, selected book chapters, and University of Michigan cases. CONCLUSIONS. — Melanotic neuroectodermal tumor of infancy most commonly occurs in the bones of the head and neck region during the first year of life, but it can also present in other locations, including the central nervous system, testes, ovaries, and subcutaneous soft tissues. Histologically, it is composed of a biphasic population of cells, consisting of epithelioid melanin-producing cells and primitive neurogenic cells in a fibrocollagenous stroma. These microscopic findings, especially in small biopsies, can lead to a broad differential diagnosis that includes malignant small round blue cell tumors and malignant melanoma. Melanotic neuroectodermal tumor of infancy commonly has an infiltrative growth pattern, and anatomic constraints often lead to incomplete resection and local recurrence, requiring multiple surgical operations. Because melanotic neuroectodermal tumor of infancy can mimic a more aggressive and aggressively treated malignancy, recognition of this rare tumor is very crucial for pathologists.
KissKissBan: a competitive human computation game for image annotation

In this paper, we propose a competitive human computation game, KissKissBan (KKB), for image annotation. KKB is different from other human computation games since it integrates both collaborative and competitive elements in the game design. In a KKB game, one player, the blocker, competeswith the other two collaborative players, the couples; while the couples try to find consensual descriptions about an image, the blocker's mission is to prevent the couples from reaching consensus. Because of its design, KKB possesses two nice properties over the traditional human computation game. First, since the blocker is encouraged to stop the couples from reaching consensual descriptions, he will try to detect and prevent coalition between the couples; therefore, these efforts naturally form a player-levelcheating-proof mechanism. Second, to evade the restrictions set by the blocker, the couples would endeavor to bring up a more diverse set of image annotations. Experiments hosted on Amazon Mechanical Turk and a gameplay survey involving 17 participants have shown that KKB is a fun and efficient game for collecting diverse image annotations.
Using Sequence to Sequence Learning for Digital BPSK and QPSK Demodulation

In the last few years Machine Learning (ML) has seen explosive growth in a wide range of research fields and industries. With the advancements in Software Defined Radio (SDR), which allows more intelligent, adaptive radio systems to be built, the wireless communications field has a number of opportunities to apply ML techniques. In this paper, a novel approach to demodulation using a Sequence to Sequence (Seq2Seq) model is proposed. This type of model is shown to work effectively with PSK data and also has a number of useful properties that are not present in other machine learning algorithms. A basic Seq2Seq implementation for BPSK and QPSK demodulation is presented in this paper, and learned properties such as Automatic Modulation Classification (AMC), and ability to adapt to different length input sequences, are demonstrated. This is an exciting new avenue of research that provides considerable potential for application in next generation 5G networks.
Numerical evaluation of the efficacy of small-caliber colonoscopes in reducing patient pain during a colonoscopy

Abstract Patient pain caused by a colonoscope is one of the main complications in completing a colonoscopy. Currently, randomized controlled trial (RCT) is one of the most used methods to evaluate the efficacy of small-caliber (SC) colonoscopes in reducing patient pain during a colonoscopy, compared with a standard colonoscope (SDC). However, many disturbing factors, including endoscopists’ skills, characteristics of patients and new technical features of the colonoscope (passive bending and high force transmission shaft), limit the reliability and generalizability of each finding in current RCTs. This paper focuses on modeling the insertion of colonoscopes within colon models using an explicit finite element method (FEM). Such a numerical model could overcome the limitations in RCTs. At the same time, it is expected to evaluate the efficacy of the small-caliber colonoscopes in reducing patient pain during a colonoscopy, while considering the effects of patient characteristics, including age, region and gender. The simulation results in this work showed that: compared with the SDC, a SC colonoscope may be more helpful in reducing discomfort for older patients, patients with smaller colon diameters and females.
Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy

Routine use of diuretics and neurohumoral activation make hypokalemia (serum K+ < 3. 5 mM) a prevalent electrolyte disorder among heart failure patients, contributing to the increased risk of ventricular arrhythmias and sudden cardiac death in heart failure. Recent experimental studies have suggested that hypokalemia-induced arrhythmias are initiated by the reduced activity of the Na+/K+-ATPase (NKA), subsequently leading to Ca2+ overload, Ca2+/Calmodulin-dependent kinase II (CaMKII) activation, and development of afterdepolarizations. In this article, we review the current mechanistic evidence of hypokalemia-induced triggered arrhythmias and discuss how molecular changes in heart failure might lower the threshold for these arrhythmias. Finally, we discuss how recent insights into hypokalemia-induced arrhythmias could have potential implications for future antiarrhythmic treatment strategies.
Interface Cues to Promote Disclosure and Build Community

Health forums and support groups depend on participant self-disclosure for their success, but the sensitive nature of personal health concerns raises privacy concerns that may constrain what users are willing to reveal. To address this issue, we explore the impact of visual cues designed to convey (1) two facets of social influence-crowd size and social network connectivity-and (2) provide a frame designed to enhance the forum's sense of community. A 3 (Cue type: Crowd, Connectivity, None) x 2 (Framing) factorial experiment (N = 218) showed that cues implying greater crowd size and connectivity lead to more self-disclosure of sensitive information, and higher intentions to revisit the community. Further, user belief in the community-building heuristic positively predicts self-disclosure and intentions, while also moderating the effect of the connectivity cue in a direction which implies that the cue encourages disclosure by triggering the community-building heuristic. Implications for the design of online groups are discussed.
Is Two Better than One?: Effects of Multiple Agents on User Persuasion

Virtual humans need to be persuasive in order to promote behaviour change in human users. While several studies have focused on understanding the numerous aspects that influence the degree of persuasion, most of them are limited to dyadic interactions. In this paper, we present an evaluation study focused on understanding the effects of multiple agents on user's persuasion. Along with gender and status (authoritative & peer), we also look at type of focus employed by the agent i. e. , user-directed where the agent aims to persuade by addressing the user directly and vicarious where the agent aims to persuade the user, who is an observer, indirectly by engaging another agent in the discussion. Participants were randomly assigned to one of the 12 conditions and presented with a persuasive message by one or several virtual agents. A questionnaire was used to measure perceived interpersonal attitude, credibility and persuasion. Results indicate that credibility positively affects persuasion. In general, multiple agent setting, irrespective of the focus, was more persuasive than single agent setting. Although, participants favored user-directed setting and reported it to be persuasive and had an increased level of trust in the agents, the actual change in persuasion score reflects that vicarious setting was the most effective in inducing behaviour change. In addition to this, the study also revealed that authoritative agents were the most persuasive.
Non-photorealistic camera: depth edge detection and stylized rendering using multi-flash imaging

We present a non-photorealistic rendering approach to capture and convey shape features of real-world scenes. We use a camera with multiple flashes that are strategically positioned to cast shadows along depth discontinuities in the scene. The projective-geometric relationship of the camera-flash setup is then exploited to detect depth discontinuities and distinguish them from intensity edges due to material discontinuities.We introduce depiction methods that utilize the detected edge features to generate stylized static and animated images. We can highlight the detected features, suppress unnecessary details or combine features from multiple images. The resulting images more clearly convey the 3D structure of the imaged scenes.We take a very different approach to capturing geometric features of a scene than traditional approaches that require reconstructing a 3D model. This results in a method that is both surprisingly simple and computationally efficient. The entire hardware/software setup can conceivably be packaged into a self-contained device no larger than existing digital cameras.
Experimental Determination of TDR Calibration Relationship for Pyroclastic Ashes of Campania (Italy)

Time domain reflectometry (TDR) is one of the most widely used techniques for indirect determination of soil volumetric water content (θ). TDR measures the relative dielectric constant (εr) which, in a three-phase system like the soil, depends on water, air, and solid matrix dielectric constants. Since dielectric constant of water is much larger than the other two, εr of bulk soil mainly depends on water content. In many cases, the application of TDR requires a specific calibration of the relationship θ(εr) to get quantitatively accurate estimates of soil water content. In fact, the relationship θ(εr) is influenced by various soil properties, such as clay content, organic matter content, bulk density, and aggregation. Numerous studies have shown that pyroclastic soils often exhibit a peculiar dielectric behavior. In Campania (Southern Italy) wide mountainous areas are covered by layered pyroclastic deposits of ashes (loamy sands) and pumices (sandy gravels), often involved in the triggering of landslides induced by rainwater infiltration. Reliable field measurements of water content of such soils are therefore important for the assessment of landslide risk. Hence, in this paper, the θ(εr) relationship has been experimentally determined on samples of typical pyroclastic soil of Campania, collected around Sarno, reconstituted with different porosities. The aim of the study is to identify specific calibration relationships for such soils based not only on empirical approaches. In this respect, a three-phase dielectric mixing model with a variable exponent is introduced, and the variable value of the exponent is related to the different dielectric properties of bond and free water within the soil pores.
Improving Empathy in Nursing Students: A Comparative Longitudinal Study of Two Curricula.

PURPOSE This study aimed to examine changes of empathy levels of nursing student in two different curricula structures, one called "traditional" and the other called "integrated" curricula. The study was a longitudinal design to follow a cohort of nursing students to examine the magnitude of changes in empathy in their education years. METHODS The study was conducted in a public school of nursing giving a baccalaureate degree, which had a fundamental change in their curricula. In all, 81 students from the traditional curricula and 66 students from the integrated curricula completed the study, and data from a total of 147 students were analyzed between 2003 and 2008. The Empathic Communication Skills Scale and the Empathic Tendency Scale were given to the students in the beginning of their freshman year and at the end of the fourth year just before graduation. RESULTS Although both of the curricula were seemed effective at improving empathic skills of students, especially the scores of students who completed the integrated curricula were higher than the scores of the other group attending the traditional curricula (p<.05). However, the empathic tendency scores of students in both curricula decreased at the end of fourth year. CONCLUSION Although undergraduate nursing curricula either traditional or integrated improved empathic skills, it seemed that integrated curricula were more effective than traditional curricula in increasing empathic skills. The more hours and more experiential methods contributed to improved empathy. The decrease in empathic tendency requires further attention of educators and nurse managers.
Integrated analysis of lncRNA–mRNA co-expression networks in the α-particle induced carcinogenesis of human branchial epithelial cells

Abstract Purpose: To identify the mRNA and long noncoding RNA (lncRNA) expression profiles and explore the lncRNA–mRNA co-expression networks associated with the carcinogenesis induced by α-particles. Materials and methods: Immortalized human bronchial epithelial cell line, BEP2D, and its two malignant transformed cell lines, BERP35T-1 and BERP35T-4, were investigated. The lncRNA and mRNA expression profiles of BEP2D, BERP35T-1 and BERP35T-4 were generated. lncRNAs and mRNAs co-expression analysis was performed. Results: The microarray identified 668 lncRNAs in BERP35T-1 cells and 555 in BERP35T-4 cells that were differentially expressed compared to BEP2D cells. The GO terms and KEGG pathway annotation data indicated that mitotic cell cycle, DNA repair, apoptotic processes, and RNA splicing functional pathways were significantly associated with the α-particle induced cell carcinogenesis. Co-expression network analysis revealed 8902 interactions between 495 differentially expressed mRNAs and 430 corresponding lncRNAs in BERP35T-1 cells compared with BEP2D cells. The genes, situated at the important nodes of the co-expression network, include B3GNT5, RAD23, YWHAZ (14-3-3ζ), FBXW11, TGFBR2, LRP6, PSMD11, MYL12A, etc. Conclusions: This pilot study is the first to explore epigenetic mechanisms of α-particle induced carcinogenesis of human bronchial epithelial cells. It provides basic information for further investigation into the detail mechanisms underlying radiation-induced lung cancer.
The Effect of Aging on Nerve Morphology and Substance P Expression in Mouse and Human Corneas.

Purpose Aging impairs corneal nerve density and sensitivity. Substance P (SP), a neuropeptide secreted by sensory nerves, regulates nerve morphology and nociception. Here, we investigate the relationship between aging, nerve morphology, and SP expression in mouse and human corneas. Methods SP levels in mouse corneas (wild type and substance P-knockout) and human corneas and tears were quantified with an ELISA assay. Corneal total nerve length (TNL) was measured with whole-mount β3-tubulin immunofluorescence in mouse and in vivo laser corneal confocal microscopy in humans. SP and β3-tubulin stained cross-sections were used to assess the colocalization of SP and nerves in human and mouse corneas. Ocular surface nociception was assessed with a wiping test in mice. Results SP colocalizes with sub-basal neurons in mice and humans. In WT mice, SP levels decrease with age (P = 0.0045, 8 vs. 52 weeks; P = 0.004, 26 vs. 52 weeks) as well as TNL (P = 0.018, 8 vs. 26 weeks; P = 0.0001, 8 vs. 52 weeks). Knockout mice show a greater TNL reduction (8 vs. 26 weeks, P = 0.0016) than WT mice. In the oldest WT and age-matched KO mice, nociception is impaired (P = 0.007 and P < 0.0001, respectively), and KO mice sensitivity is restored by topical SP treatment. In humans, SP levels are reduced in old subject corneas and correlate, in tears, with age (P = 0.0368); TNL also decreases in older patients (P = 0.0002). Conclusions Age-associated corneal nerve loss is paralleled by reduction of SP expression in mice and humans. SP promotes the maintenance of normal nerve morphology in the long term and modulates nociception in the cornea.
A fully coupled fluid-structure interaction model of the secondary lymphatic valve

Abstract The secondary lymphatic valve is a bi-leaflet structure frequent throughout collecting vessels that serves to prevent retrograde flow of lymph. Despite its vital function in lymph flow and apparent importance in disease development, the lymphatic valve and its associated fluid dynamics have been largely understudied. The goal of this work was to construct a physiologically relevant computational model of an idealized rat mesenteric lymphatic valve using fully coupled fluid-structure interactions to investigate the relationship between three-dimensional flow patterns and stress/deformation within the valve leaflets. The minimum valve resistance to flow, which has been shown to be an important parameter in effective lymphatic pumping, was computed as 268 g/mm4−s. Hysteretic behavior of the lymphatic valve was confirmed by comparing resistance values for a given transvalvular pressure drop during opening and closing. Furthermore, eddy structures were present within the sinus adjacent to the valve leaflets in what appear to be areas of vortical flow; the eddy structures were characterized by non-zero velocity values (up to ∼4 mm/s) in response to an applied unsteady transvalvular pressure. These modeling capabilities present a useful platform for investigating the complex interplay between soft tissue motion and fluid dynamics of lymphatic valves and contribute to the breadth of knowledge regarding the importance of biomechanics in lymphatic system function.
Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity

Abstract The anti-parasitic benzimidazole flubendazole has been used for many years to treat intestinal infections in humans and animals. Previous genotoxicity studies have shown that the compound is not a bacterial mutagen and a bone marrow micronucleus test, using a formulation that limited systemic absorption, was negative. The purpose of this study is to explore the genotoxicity of flubendazole and its main metabolites in in vitro micronucleus studies and to test a new oral formulation that improves systemic absorption in an in vivo micronucleus test. The isolated metabolites were also screened using the Ames test for bacterial mutagenicity. It was found that flubendazole, like other chemically related benzimidazoles used in anti-parasitic therapies, is a potent aneugen in vitro. The hydrolysed metabolite of flubendazole is negative in these tests, but the reduced metabolite (R- and S-forms) shows both aneugenic and clastogenic activity. However, in vitro micronucleus tests of flubendazole in the presence of rat liver S9 gave almost identical signals for aneugenicity as they did in the absence of S9, suggesting that any clastogenicity from the reduced metabolite is not sufficient to change the overall profile. Like flubendazole itself, both metabolites are negative in the Ames test. Analysis of dose–response curves from the in vitro tests, using recently developed point of departure approaches, demonstrate that the aneugenic potency of flubendazole is very similar to related anti-parasitic benzimidazoles, including albendazole, which is used in mass drug administration programmes to combat endemic filarial diseases. The in vivo micronucleus test of the new formulation of flubendazole also showed evidence of induced aneugenicity. Analysis of the in vivo data allowed a reference dose for aneugenicity to be established which can be compared with therapeutic exposures of flubendazole when this has been established. Analysis of the plasma from the animals used in the in vivo micronucleus test showed that there is increased exposure to flubendazole compared with previously tested formulations, as well as significant formation of the non-genotoxic hydrolysed metabolite of flubendazole and small levels of the reduced metabolite. In conclusion, this study shows that flubendazole is a potent aneugen in vitro with similar potency to chemically related benzimidazoles currently used as anti-parasitic therapies. The reduced metabolite also has aneugenic properties as well as clastogenic properties. Treatment with a new formulation of flubendazole that allows increased systemic exposure, compared with previously used formulations, also results in detectable aneugenicity in vivo. Based on the lack of carcinogenicity of this class of benzimidazoles and the intended short-term dosing, it is unlikely that flubendazole treatment will pose a carcinogenic risk to patients.
Psychosocial factors as predictors of dropout in ultra-trailers

Objective Although research on the physiological and psychological factors of endurance performance has been extensive, the factors related to dropping out of ultra-trail races have not been well documented. The aim of this study was to examine psychosocial factors as predictors of dropout in ultra-trail runners. Methods Two hundred and twenty-one volunteer athletes completed a survey that included measures of: (a) motivational variables (self-determined motivation, basic needs satisfaction, achievement goals), (b) theory of planned behavior constructs (attitudes, subjective norms, self-efficacy and intention to finish the race), and (c) coping strategies in sport. Results The results showed that finishers had higher scores for self-efficacy and intention to finish the race than withdrawers, whereas withdrawers had higher scores for avoidance coping. Multiple logistic regression showed that the number of started and finished ultra-trail races (OR, 0.44; 95% CI 0.22–0.88; p<0.02), self-efficacy (OR, 2.03; 95% CI 1.06–3.89; p<0.04), intention to finish the race (OR, 0.34; 95% CI 0.16–0.71; p<0.004), mastery-approach goals (OR, 0.56; 95% CI 0.31–1.00; p<0.05), and coping strategies of seeking social support (OR, 0.43; 95% CI 0.26–0.71; p<0.001) were associated with a lower risk of race dropout, whereas avoidance coping strategies (OR, 2.26; 95% CI 1.46–3.52; p<0.001) were associated with an increased dropout rate. Conclusion Interventions promoting self-efficacy constructs and specific coping strategies might contribute to preventing dropout in ultra-trailers.
Online shopping in Sub-Saharan Africa: evidence from Ghana

Using extended UTAUTII and Structural Equation Modelling, we develop hypotheses regarding the factors influencing the behaviour of online shopping in the sub-Saharan Africa and test them on a sample of 400 online shoppers in Ghana. We find positive correlation between the independent variables (social influence, performance expectancy, habit, facilitating condition, and trust) and behavioural intention, which is consistent with the findings in developed countries. The study not only extends hedonic motivation in UTAUTII model to include service quality and value proposition, but also precisely demonstrates that the extent to which an online shopper derives fun or pleasure to continuously use online shopping is influenced by the value proposition offered by merchants. We find strong empirical support that value proposition is affected by service quality. The results also help to explain how generational cohort of X and Y, gender, and marital status are online shopping influencers in the sub-Saharan Africa.