Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomized Clinical Trials on Deep Carious Lesions: 5-Year Follow-up

Deep caries presents a dilemma in terms of which treatment that will render an optimal prognosis by maintaining pulp vitality with absence of apical pathology. Previously, 2 randomized clinical trials were performed testing the short-term effects of stepwise carious tissue removal versus nonselective carious removal to hard dentin with or without pulp exposure. The aim of this article was to report the 5-y outcome on these previously treated patients having radiographically well-defined carious lesions extending into the pulpal quarter of the dentin but with a well-defined radiodense zone between the carious lesion and the pulp. In this long-term study, 239 of 314 (76.2%) patients were analyzed. The stepwise removal group had a significantly higher proportion of success (60.2%) at 5-y follow-up compared with the nonselective carious removal to hard dentin group (46.3%) (P = 0.031) when pulp exposures per se were included as failures. Pulp exposure rate was significantly lower in the stepwise carious removal group (21.2% vs. 35.5%; P = 0.014). Irrespective of pulp exposure status, the difference (13.3%) was still significant when sustained pulp vitality without apical radiolucency and unbearable pain was considered (95% confidence interval, 3.1–26.3, P = 0.045). After pulp exposure, only 9% (n = 4) of the analyzed patients were assessed as successful, indicating that the prognosis is highly dubious following conventional pulp-capping procedures (direct pulp capping or partial pulpotomy) in deep carious lesions in adults. In conclusion, the stepwise carious removal group had a significantly higher proportion of pulps with sustained vitality without apical radiolucency versus nonselective carious removal of deep carious lesions in adult teeth at 5-y follow-up (ClinicalTrials.gov NCT00187837 and NCT00187850).
Nordic couples’ decision-making processes in anticipation of contacting a fertility clinic

Objective: To explore the decision-making processes of Nordic couples in anticipation of contacting a fertility clinic after experiencing difficulties in conceiving. Method: A retrospective descriptive qualitative study of 22 heterosexual infertile couples recruited from fertility clinics in all five Nordic countries. Results: The process comprises three decisions: (i) accepting that they have a shared problem, (ii) acknowledging the need for more knowledge and (iii) taking action to get help. Subcategories were: (i) infertile or not, maintain the balance in the relationship; (ii) information from social networks and information from the health care system; (iii) having an alternative plan and fear of a wrong decision. The core category was ‘negotiation and re-negotiation’. Differences between the countries were found with regard to the time couples waited before contacting a fertility clinic, and in the utilisation of private vs. public clinics. Conclusion: It requires a process of negotiation and re-negotiation for couples to reach a compromise. Furthermore, the decision-making process is influenced by the structure of health care services in respective countries.
Expression of Phosphate Transporters during Dental Mineralization

The importance of phosphate (Pi) as an essential component of hydroxyapatite crystals suggests a key role for membrane proteins controlling Pi uptake during mineralization in the tooth. To clarify the involvement of the currently known Pi transporters (Slc17a1, Slc34a1, Slc34a2, Slc34a3, Slc20a1, Slc20a2, and Xpr1) during tooth development and mineralization, we determined their spatiotemporal expression in murine tooth germs from embryonic day 14.5 to postnatal day 15 and in human dental samples from Nolla stages 6 to 9. Using real-time polymerase chain reaction, in situ hybridization, immunohistochemistry, and X-gal staining, we showed that the expression of Slc17a1, Slc34a1, and Slc34a3 in tooth germs from C57BL/6 mice were very low. In contrast, Slc34a2, Slc20a1, Slc20a2, and Xpr1 were highly expressed, mostly during the postnatal stages. The expression of Slc20a2 was 2- to 10-fold higher than the other transporters. Comparable results were obtained in human tooth germs. In mice, Slc34a2 and Slc20a1 were predominantly expressed in ameloblasts but not odontoblasts, while Slc20a2 was detected neither in ameloblasts nor in odontoblasts. Rather, Slc20a2 was highly expressed in the stratum intermedium and the subodontoblastic cell layer. Although Slc20a2 knockout mice did not show enamel defects, mutant mice showed a disrupted dentin mineralization, displaying unmerged calcospherites at the mineralization front. This latter phenotypical finding raises the possibility that Slc20a2 may play an indirect role in regulating the extracellular Pi availability for mineralizing cells rather than a direct role in mediating Pi transport through mineralizing plasma cell membranes. By documenting the spatiotemporal expression of Pi transporters in the tooth, our data support the possibility that the currently known Pi transporters may be dispensable for the initiation of dental mineralization and may rather be involved later during the tooth mineralization scheme.
Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel

Regenerative medicine-based approaches for caries treatment focus on biomimetic remineralization of initial carious lesions as a minimal invasive therapy. In vitro, self-assembling peptide P11-4 enhances remineralization of early carious lesions. To investigate the safety and clinical efficacy of P11-4 for treatment of initial caries, a randomized controlled single-blind study was conducted on children aged >5 y with visible active early caries on erupting permanent molars. Subjects were randomized to either the test group (P11-4 + fluoride varnish) or control group (fluoride varnish alone). Caries were assessed at baseline and at 3 and 6 mo posttreatment per laser fluorescence, a visual analog scale, the International Caries Detection and Assessment System, and Nyvad caries activity criteria. Intention-to-treat analyses were performed, and safety and clinical feasibility of the treatment approaches were assessed. Compared with the control group, the test group showed clinically and statistically significant improvement in all outcomes at 3 and 6 mo. The laser fluorescence readings (odds ratio = 3.5, P = 0.015) and visual analog scale scores (odds ratio = 7.9, P < .0001) were significantly lower for the test group, and they showed regression in the International Caries Detection and Assessment System caries index (odds ratio = 5.1, P = 0.018) and conversion from active to inactive lesions according to Nyvad criteria (odds ratio = 12.2, P < 0.0001). No adverse events occurred. The biomimetic mineralization facilitated by P11-4 in combination with fluoride application is a simple, safe, and effective noninvasive treatment for early carious lesions that is superior to the presently used gold standard of fluoride alone. By regenerating enamel tissue and preventing lesion progression, this novel approach could change clinical dental practice from a restorative to a therapeutic approach. This could avoid additional loss of healthy hard tissue during invasive restorative treatments, potentially enabling longer tooth life and thereby lowering long-term health costs (ClinicalTrials.gov NCT02724592).
Support needs of women who continue to smoke in pregnancy

This article reports the findings from an exploratory, descriptive survey to assess pregnant smokers' awareness, attitudes and behaviour in relation to smoking in pregnancy and the support needed to help them stop. One hundred and fifty women attending antenatal clinics within an acute health-care trust hospital in Northern Ireland and who continued to smoke in pregnancy were asked to complete a questionnaire. One hundred and twenty-three women participated. Findings identified smoking habits were established in early teenage years. Most women were not aware of many of the dangers associated with continuing to smoke in pregnancy. Having a partner who smoked was negatively associated with women's cessation of smoking in pregnancy. The findings also suggest that once the smoking habit is established addiction makes it more difficult for women to quit. Therefore, if smoking prevalence among pregnant women is to be reduced preventive and early intervention programmes must start early in school life. For those.
Ancient injury recidivism: An example from the Kerma Period of ancient Nubia

A topical trend in clinical research has been the study of repeat trauma, referred to by clinicians as “injury recidivism,” which lends itself to the assessment of accumulated injuries among ancient people. The present investigation examined the healed injuries among two archaeological skeletal samples from the Kerma period (ca. 2500–1500 BC) of Sudanese Nubia. Both groups were known to have a high prevalence of multiple trauma—80% of 54 adults from the rural sites (O16 and P37) located near Dongola and 42% of 212 adults from the urban site of Kerma sustained nonfatal injuries. It was observed that a higher frequency of multi-injured adults displayed one or more violence-associated injury (cranial trauma, parry fracture). When all injuries were considered 38% of individuals with violence-related injuries had other traumatic lesions in contrast to 22% of individuals who experienced injuries associated with accidental falls (e.g., Colles', Smiths', Galeazzi, and paired forearm fractures), although this difference was not significant. When only the skulls and long bones were evaluated 81% of adults with multiple injuries to these major bones bore one or more violence-related injuries, while 60% of adults with single injuries sustained violence-related injuries. Most individuals with multiple injuries were male and less than 35 years of age; there was no significant difference in the frequency of violence- or accident-related multiple injury between the rural and urban communities. Although it cannot be established whether or not some of an individual's injuries were experienced during simultaneous or independent incidents, the pattern of multiple injury among these two ancient Nubian skeletal samples reflected the profile of injury recidivism observed by modern clinicians cross-culturally. Copyright © 2002 John Wiley & Sons, Ltd.
Economic Hardship and Depression across the Life Course

Previous research in the United States suggests that depression related to economic hardship decreases with age. We test whether this pattern can be generalized to other developed nations. Based on data from 23 countries in the European Social Survey (2006–2007), multilevel analyses show that the moderating role of age depends on the socio-political context. While the hardship–depression link is not significantly different across the life course in Nordic and Bismarckian regimes, the hardship–depression link increases with age in Southern and Eastern European countries and decreases with age in strength in Anglo-Saxon welfare states. Our findings suggest that welfare state regimes play a significant role in attenuating, boosting, or even reversing the health effects of social experiences such as economic hardship on aging. Health knowledge gained through research that ignores the socio-political context may be limited in terms of generalization.
Racial Differences in Depression Trajectories among Older Women

Despite recent increases in life course research on mental illness, important questions remain about the social patterning of, and explanations for, depression trajectories among women in later life. The authors investigate competing theoretical frameworks for the age patterning of depressive symptoms and the physical health, socioeconomic, and family mechanisms differentiating black and white women. Using data from the National Longitudinal Survey of Mature Women, the authors use linear mixed (growth curve) models to estimate trajectories of distress for women aged 52 to 81 years (N = 3,182). The results demonstrate that: (1) there are persistently higher levels of depressive symptoms among black women relative to white women throughout later life; (2) physical health and socioeconomic status account for much of the racial gap in depressive symptoms; and (3) marital status moderates race differences in distress. The findings highlight the importance of physical health, family, and socioeconomic status in racial disparities in mental health.
Integrating Medical and Environmental Sociology with Environmental Health

This article reviews the personal and professional processes of developing an interdisciplinary approach to understanding the complex issues of environmental health in their community, political-economic, social science, and scientific contexts. This interdisciplinary approach includes a synthesis of research, policy work, and advocacy. To examine multiple forms of interdisciplinarity, I examine pathways of integrating medical and environmental sociology via three challenges to the boundaries of traditional research: (1) crossing the boundaries of medical and environmental sociology, (2) linking social science and environmental health science, and (3) crossing the boundary of research and advocacy. These boundary crossings are discussed in light of conceptual and theoretical developments of popular epidemiology, contested illnesses, and health social movements. This interdisciplinary work offers a more comprehensive sociological lens for understanding complex problems and a practical ability to join with scientists, activists, and officials to meet public health needs for amelioration and prevention of environmental health threats.
Healthy Time Use in the Encore Years

Social engagement is theorized to promote health, with ages 55 to 75—what some call “encore” adulthood—potentially being a time for ongoing engagement or social isolation. We use the American Time Use Survey (N = 11,952) and a life course perspective to examine associations between paid work, resources, relations, and healthy time use for men and women in the first (55–64) and second (65–74) halves of the encore years. Work limits sufficient sleep (full-time working men) and television watching (all workers) but also time spent in physical activity (full-time workers). College-educated and healthy encore adults—across age and gender divides—are more likely to exercise and watch less television. Marriage and caregiving encourage socializing and limit television watching, despite differential effects on physical activity and sleep. These findings fit well with a gendered life course perspective suggesting socially patterned (by work, resources, relationships, gender, age) health behaviors.
Economic Security, Social Cohesion, and Depression Disparities in Post-transition Societies

Although both China and Russia have experienced several decades of market reform, initial evidence suggests that this structural change has compromised mental and physical health among the Russian population but not the Chinese population. Using data from the World Health Organization Study on Global AGEing and Adult Health (2007–2010), this study examines the factors associated with the disparity in depression between older adults in China and their Russian counterparts, all of whom experienced market transition in the prime of their lives (N = 10,896). Results show that the lower level of depression among Chinese respondents is attributable to higher levels of economic security and social cohesion as well as stronger effects of economic and social resources on depression, while health-rating style is likely a minor factor. The study advances the sociological understanding of global/comparative mental health by considering the effects of macrolevel political, economic, social, and cultural conditions.
Developmental Links of Very Early Phonological and Language Skills to Second Grade Reading Outcomes

The authors examined second grade reading accuracy and fluency and their associations via letter knowledge to phonological and language predictors assessed at 3.5, 4.5, and 5.5 years in children in the Jyväskylä Longitudinal Study of Dyslexia. Structural equation modeling showed that a developmentally highly stable factor (early phonological and language processing [EPLP]) behind key dyslexia predictors (i.e., phonological awareness, short-term memory, rapid naming, vocabulary, and pseudoword repetition) could already be identified at 3.5 years. EPLP was significantly associated with reading and spelling accuracy and by age with letter knowledge. However, EPLP had only a minor link with reading fluency, which was additionally explained by early letter knowledge. The results show that reading accuracy is well predicted by early phonological and language skills. Variation in fluent reading skills is not well explained by early skills, suggesting factors other than phonological core skills. Future research is suggested to explore the factors behind the development of fast and accurate decoding skills.
Effects of Pressure Ulcer Classification System Education Program on Knowledge and Visual Discrimination Ability of Pressure Ulcer Classification and Incontinence-Associated Dermatitis for Hospital Nurses

One group pre- and post-test was used. A convenience sample of 96 nurses participating in pressure ulcer classification system edu-cation, were enrolled in single institute. The education program was composed of a 50-minute lecture on pressure ulcer classification system and case-studies. The pressure ulcer classification system and incontinence-associated dermatitis knowledge test and visual discrimination tool, consisting of 21 photographs including clinical information were used. Paired t-test was performed using SPSS/WIN 18.0.
Goal Priming and the Emotional Experience of Students With and Without Attention Problems

The primary purpose of the present study is to evaluate the emotional experience of students with (n = 52) and without attention problems (n = 272) during an achievement task. A secondary purpose of the present study is to compare students' emotional response to various stimuli, when motivated by various achievement goals. Participants were randomly assigned into a mastery goal condition, a normative performance goal condition, and a non-normative performance goal condition. Results, using a latent means analysis, indicate that students with attention problems needed additional time to process emotion-loaded but not neutral words, providing evidence for an interference effect. Furthermore, students in the performance-normative, relative to the performance non-normative, condition showed a salient interference effect with respect to various emotion-loaded and neutral words.
Impacts of Comprehensive Reading Instruction on Diverse Outcomes of Low- and High-Achieving Readers

Low-achieving readers in Grade 5 often lack comprehension strategies, domain knowledge, word recognition skills, fluency, and motivation to read. Students with such multiple reading needs seem likely to benefit from instruction that supports each of these reading processes. The authors tested this expectation experimentally by comparing the effects of Concept-Oriented Reading Instruction (CORI) with traditional instruction (TI) on several outcomes in a 12-week intervention for low achievers and high achievers. Low achievers in the CORI group were afforded explicit instruction, leveled texts, and motivation support. Compared with TI students, CORI students scored higher on posttest measures of word recognition speed, reading comprehension on the Gates-MacGinitie Reading Test, and ecological knowledge. CORI was equally effective for lower achievers and higher achievers. Explicitly supporting multiple aspects of reading simultaneously appeared to benefit diverse learners on a range of reading outcomes.
THE SYMPTOMATOLOGY OF TRIFACIAL NEURALGIA

Identified as a morbid entity more than 120 years ago, 1 seen by almost every practicing physician, and known now as always by its clinical features alone, some misbeliefs concerning the symptomatology of trifacial neuralgia, tic douloureux, are more or less current. Hence the following brief review of the subject based on 220 personal cases, although only 200 have been tabulated for statistical purposes. So far as I have been able to ascertain, these were all cases of true trifacial neuralgia, typical tic doloureux, la grande nevralgie of Levy; 2 not migraine, not sinus disease, not herpes or other symptomatic pains about the face. For, as Head 3 says, "This is a definite disease of the nervous system"; as a German colleague put it, etwas fur sich , something sui generis , not to be confused in nature or doings with anything else. In most of my cases the diagnosis was confirmed
Still Wanted

My long-standing concern about the preparation and professional development of teachers responsible for preventing and remediating reading and spelling disabilities (Moats, 1994, 1995, 1999, 2009) is shared by many colleagues (Bos, Mather, Dickson, Podhajski, & Chard, 2001; Brady & Moats, 1997; Mather, Bos, & Babur, 2001; Moats & Foorman, 2003; Moats & Lyon, 1996). In our classrooms, workshops, and research studies, we find that teachers often feel unprepared to address the instructional needs of students with language, reading, and writing problems, although these groups compose the large majority of those in remedial and special education. Teachers often have minimal understanding of how students learn to read and write or why many of their students experience difficulty with this most fundamental task of schooling. Although the quality of implementation of an instructional program has everything to do with its success (Haager, Heimbichner, Dhar, Moulton, & McMillan, 2008), poor implementation of adopted programs is a major reason why students at risk fail to progress. Unfortunately, current educational policies and funding practices continue to focus on program selection, school organization, and student test scores—not teachers, the contexts in which they teach, or the leadership and professional development required to ensure “teacher quality. ” Thus, the research on teachers and teaching reported in this special issue of Journal of Learning Disabilities (JLD) is all the more welcome and needed. This special issue of JLD enables us to consider why reading, writing, and language instruction may not be effective even though federal, state, and local policies may promote the value of evidence-based reading programs. The contributors to this issue consider the content knowledge, attitudes, learning experiences, and working environments that support teachers’ ability and willingness to implement research-based instruction. Teachers cannot teach well what they do not understand themselves, and these articles help explain why deep understanding is hard for teachers to acquire and why the path to progress is more complex than sometimes realized. Below is a brief summary of some obstacles to improvement that have been underappreciated in the past and that come to light in this issue.