Miracle-dz/UniFAR-FTUs huggingface dataset:
Medication use for acute coronary syndrome in Vietnam

Ischemische hartziekten (IHZ), waaronder acuut coronair syndroom (ACS), vormen 's werelds grootste doodsoorzaak. Het doel van dit proefschrift is inzicht krijgen in het proces van geneesmiddelgebruik en interventies ter verbetering van geneesmiddelgebruik voor patienten in Vietnam. Het eerste deel focuste op de navolging van voorschrijfrichtlijnen door artsen. Een cross-sectionele studie wees uit dat artsen zich strikt houden aan de voorschrijfrichtlijnen bij het voorschrijven van de meeste geneesmiddelen, behalve beta-blokkers. In een cohortstudie vonden we dat ongeveer de helft van de patienten medicatie kreeg voorgeschreven volgens de richtlijnen. Dit resulteerde in een daling van 29% in mortaliteit en ziekenhuis heropnames bij patienten met deze medicatie. Een literatuuronderzoek toonde aan dat veranderingen in de organisatie van de zorg en training van zorgprofessionals enkel het voorschrijven van statines verbeterde en zorgde voor verbeterde bloeddruk controle. Het tweede deel focuste op de therapietrouw van de patient. We hebben vragenlijsten voor het meten van patient-perspectieven met betrekking tot geneesmiddelgebruik vertaald in het Vietnamees en cross-cultureel aangepast. In een observationele studie vonden we de dat driekwart van de patienten met ACS zes maanden na ontslag therapietrouw was. Een gerandomiseerde gecontroleerde interventiestudie toonde aan dat medicatiebegeleiding door de apotheker, patientgerichte educatie en medicatie hulpmiddelen leidden tot een toename van ruim 13% in het aantal therapietrouwe patienten binnen drie maanden na ontslag, maar had geen effect op de kwaliteit van leven, mortaliteit en ziekenhuis heropname. Onze resultaten dragen bij aan de verbetering van de gezondheidszorg voor IHZ en daarmee de patientenzorg in Vietnam en vergelijkbare lage- en middeninkomenslanden.
TEACHING LEADERSHIP IN AGRICULTURAL SCIENCE: BEHAVIORAL FACTORS THAT INFLUENCE SECONDARY AGRICULTURAL SCIENCE LEADERSHIP INSTRUCTION

This study sought to explain why agricultural science instructors teach leadership in their classrooms. The variables measured were instructor leadership teaching behavior, instructor attitude towards teaching leadership, instructor demographics, instructor leadership knowledge, and instructor expectations of students after the teaching of leadership. In this national study 400 participants were contacted and 167 responded to the questionnaire. This study revealed that instructor attitude towards teaching leadership, selected instructor demographics, and instructor expectations were significant predictors of instructor leadership teaching behavior. Instructor leadership knowledge had no significant contribution to instructor leadership teaching behavior. It was recommended that pre-service instructors be encouraged to take a leadership course so they will be better prepared to teach leadership concepts as an instructor; leadership professional development programs should be offered to current instructors to increase instructor leadership knowledge; and teacher preparation institutions should provide pre-service instructors with LifeKnowledge curriculum training so new agriculture instructors will be prepared to teach leadership in agricultural science classrooms.
A Subset of the Follicular Variant of Papillary Thyroid Carcinoma Harbors the PAX8-PPARγ Translocation

The occurrence of the PAX8-PPARγ fusion gene is thought to be restricted to follicular tumors (adenomas and carcinomas) of the thyroid (FTA and FTC). Using interphase fluorescent in situ hybridization (FISH), together with recombinant tissue-type polymerase chain reaction (RT-PCR) and immunohistochemistry, we detected the PAX8-PPARγ translocation in 4 of 8 cases of the follicular variant of papillary thyroid carcinoma (FVPTC) exclusively or almost exclusively (>95%) composed of follicles. The 4 tumors with the translocation were larger and apparently more invasive than the remaining tumors, but the series is too small to allow a statistically meaningful comparison of the data. Our findings show that follicular thyroid carcinoma (PTC) may also harbor the PAX8-PPARγ fusion gene and indicate that a subset of FVPTC shares some molecular features of FTA and FTC.
CTL priming by CD8+ and CD8– dendritic cells in vivo

Two distinct developmental pathways are driving the formation of myeloid‐ and lymphoid‐related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid‐related CD8– DC are able to initiate immune responses, whereas the lymphoid‐related CD8+ DC have been suggested to induce tolerance. Here we show that both subsets activate CD8+ T cells in vitro and induce protective anti‐viral CTL responses in vivo. Thus, vaccine strategies using peptide‐pulsed DC do not have to take into account DC subsets for priming.
Maternal smoking and blood pressure in different trimesters of pregnancy: The Generation R Study

Objective Smoking during pregnancy is a risk factor for various adverse birth outcomes but lowers the risk of preeclampsia. Cardiovascular adaptations might underlie these associations. We examined the associations of smoking in different trimesters of pregnancy with repeatedly measured blood pressure and the risks of preeclampsia and pregnancy-induced hypertension in a low-risk population-based cohort of 7106 pregnant women. Methods This study was embedded in a population-based prospective cohort study from early pregnancy onwards. Smoking and systolic and diastolic blood pressures were assessed by questionnaires and physical examinations in each trimester of pregnancy. Information about preeclampsia and pregnancy-induced hypertension was obtained from medical records. Results Compared to nonsmoking women, both first-trimester-only and continued smoking were associated with a steeper increase for systolic blood pressure and a lowest mid-pregnancy level and steeper increase thereafter for diastolic blood pressure throughout pregnancy. We did not find any significant associations in risk of preeclampsia for first-trimester-only smoking (odds ratio of 1.28, 95% confidence interval 0.74, 2.21) and continued smoking (odds ratio of 0.83, 95% confidence interval 0.50, 1.36), respectively. Conclusions Our results suggest that both first-trimester-only and continued smoking are associated with persistent maternal cardiovascular adaptations during pregnancy. Strategies for prevention of smoking during pregnancy should be focused on the preconception period. The effects of early and late-pregnancy smoking on the risk of preeclampsia should be further explored. Our results should be carefully interpreted to the general population of pregnant women.
Factors that bind to adeno-associated virus terminal repeats

We have identified and characterized a DNA-protein complex that forms with the adeno-associated virus (AAV) terminal repeats. The complex formed only if the terminal palindrome was in the covalently closed or hairpin configuration; little if any binding was detected with the open duplex form of the terminal repeat. This fact suggested that both secondary structure and primary sequence are essential elements of recognition. DNase I protection studies indicated that virtually all of the A-A' palindrome and significant portions of the B-B' and C-C' palindromes are protected. The postulated terminal resolution site of AAV also is protected. Restriction mapping of the sequences necessary for binding indicated that almost all of the terminal palindrome must be present for binding to occur. Hairpins which are similar in size and shape to the AAV termini did not exhibit competition for binding, and the complex formed only if AAV-infected extracts were used. Thus, the binding reaction is specific for AAV sequences. The viral-coded nonstructural proteins Rep78 and Rep68 comigrated with the DNA-protein complex on neutral acrylamide gels, suggesting that one or both of these proteins are components of the complex. The characteristics of the complex suggested that it has a role in AAV DNA replication.
Validating a Rapid, Automated Test of Spatial Release From Masking

Purpose To evaluate the test–retest reliability of a headphone-based spatial release from a masking task with two maskers (referred to here as the SR2) and to describe its relationship to the same test done over loudspeakers in an anechoic chamber (the SR2A). We explore what thresholds tell us about certain populations (such as older individuals or individuals with hearing impairment) and discuss how the SR2 might be useful in the clinic. Method Fifty-four participants completed speech intelligibility tests in which a target phrase and two masking phrases from the Coordinate Response Measure corpus (Bolia, Nelson, Ericson, & Simpson, 2000) were presented either via earphones using a virtual spatial array or via loudspeakers in an anechoic chamber. For the SR2, the target sentence was always at 0° azimuth angle, and the maskers were either colocated at 0° or positioned at ± 45°. For the SR2A, the target was located at 0°, and the maskers were colocated or located at ± 15°, ± 30°, ± 45°, ± 90°, or ± 135°. Spatial release from masking was determined as the difference between thresholds in the colocated condition and each spatially separated condition. All participants completed the SR2 at least twice, and 29 of the individuals who completed the SR2 at least twice also participated in the SR2A. In a second experiment, 40 participants completed the SR2 8 times, and the changes in performance were evaluated as a function of test repetition. Results Mean thresholds were slightly better on the SR2 after the first repetition but were consistent across 8 subsequent testing sessions. Performance was consistent for the SR2A, regardless of the number of times testing was repeated. The SR2, which simulates 45° separations of target and maskers, produced spatially separated thresholds that were similar to thresholds obtained with 30° of separation in the anechoic chamber. Over headphones and in the anechoic chamber, pure-tone average was a strong predictor of spatial release, whereas age only reached significance for colocated conditions. Conclusions The SR2 is a reliable and effective method of testing spatial release from masking, suitable for screening abnormal listening abilities and for tracking rehabilitation over time. Future work should focus on developing and validating rapid, automated testing to identify the ability of listeners to benefit from high-frequency amplification, smaller spatial separations, and larger spectral differences among talkers.
A structural equation model of dyadic relationships within the family system.

Ideas about the association between family interaction patterns and mental health have inspired a great deal of research on family relationships. Conventional statistical models (e.g., analysis of variance), however, are not suited for the analysis of the nonindependent observations produced by family systems; yet, these sources of nonindependence (e.g., reciprocity, partner effects) are very interesting to many family researchers. This article demonstrates how structural equation modeling enables the study of family processes in a way that is consistent with a systems perspective. An analysis of perceived coerciveness in 2-parent, 2-child families illustrates the method.
Improving outcomes for composite grafts in nasal reconstruction

Purpose of reviewAuricular composite grafting is a useful technique for the reconstruction of select nasal defects. However, unpredictable graft survival has been the primary limitation of this technique. The literature was reviewed to evaluate the effectiveness of various surgical, pharmacologic, hyperbaric, and hypothermic interventions to improve composite graft survival. Recent findingsAlthough no statistically significant surgical interventions were found, several techniques appear promising. There are a number of studies demonstrating the beneficial effects of perioperative and postoperative corticosteroid administration. Other agents studied have had modest to no benefit. Hyperbaric oxygen therapy holds promise but the expense, practicality, and lack of an established optimal treatment protocol remain obstacles to routine use. SummaryThe use of corticosteroids and postoperative cooling are relatively inexpensive and effective modalities to improve auricular composite graft survival when used for nasal reconstruction. Hyperbaric oxygen therapy may have a role, but more research is needed before it is employed routinely.
Enkephalins modulate differentiation of normal human keratinocytes in vitro

Abstract Opioid peptides are a group of neuropeptides which include enkephalins, endorphins and dynorphins. In addition to their central and peripheral antinociceptive function, opioids can modulate immune activity and cell proliferation. Previously, we have shown that enkephalins are present in macrophages infiltrating the dermal papillae in involved psoriatic skin and that the amount of enkephalin is significantly increased in involved psoriatic skin. Because enkephalins were detected close to the epidermis, we examined the effects of opioid peptides on the differentiation (transglutaminase type 1 activity and cytokeratin 10 expression) and proliferation (MTT assay) of cultured human keratinocytes. Enkephalins (methionine‐enkephalin, leucine‐cnkephalin and the synthetic DADL) inhibited cell differentiation dose‐dependently, while β‐endorphin had no effect. The opioid receptor antagonist naltrexone completely antagonized the inhibitory effect of methionine‐enkephalin and leucine‐enkephalin. but not that of DADL. Furthermore, methionine‐enkephalin had a slight inhibitory effect on the proliferation of keralinocytcs. Enkephalin was detected in unstimulated keratinocyte cultures, and naltrexone alone stimulated keratinocyte differentiation. These results indicate that enkephalins may play a role in the differentiation of epidermal keratinocytes. It remains to be determined whether the enkephalin detected in psoriatic skin are sufficient to affect epidermal differentiation in vivo.
A Fuzzy based Model for Effort Estimation in Scrum Projects

This paper aims to utilize the fuzzy logic concepts to improve the effort estimation in Scrum framework and in turn add a significant enhancement to Scrum. Scrum framework is one of the most popular agile methods in which the team accomplishes their work by breaking down the work into a series of sprints. In Scrum, there are many factors that have a significant influence on the effort estimation of each task in a Sprint. These factors are: Development Team Experience, Task Complexity, Task Size, and Estimation Accuracy. These factors are usually presented using linguistic quantifiers. Therefore, this paper utilizes the fuzzy logic concepts to build a fuzzy based model that can improve the effort estimation in Scrum framework. The proposed model includes three components: fuzzifier, inference engine, and defuzzifier. In addition, the proposed model takes into consideration the feedback that is resulted from comparing the estimated effort and the actual effort. The researcher designed the proposed model using MATLAB. The proposed model is applied on three Sprints of a real software development project to present how the proposed model works and to show how it becomes more accurate over time and gives a better effort estimation. In addition, the Scrum Master and the development team can use the proposed model to monitor the improvement in effort estimation accuracy over the project life.
Recent trends in incidence of nonmelanoma skin cancers in the East of Scotland, 1992–2003

Background Historically, ascertainment of nonmelanoma skin cancer (NMSC) by cancer registries in the U.K. has been shown to be incomplete in several studies. However, recent evidence suggesting that almost all clinically diagnosed NMSCs are verified histologically, coupled with the increasing availability of electronic histopathology data to cancer registries, raises the possibility that this situation may have improved.
The retinotopic organization of area 17 (striate cortex) in the cat

The location and retinotopic organization of visual areas in the cat cortex were determined by systematically mapping visual cortex in over 100 cats. The positions of the receptive fields of single neurons or small clusters of neurons were related to the locations of the corresponding recording sites in the cortex to determine the representations of the visual field in these cortical areas. In this report, the first of a series, we describe the organization of area 17. A single representation of the cat's entire visual field corresponds closely to the cytoarchitectonically defined area 17.
Early loading of maxillary fixed cross-arch dental prostheses supported by six or eight oxidized titanium implants: results after 1 year of loading, case series.

BACKGROUND Recent reports have demonstrated that immediate/early loading of dental implants is a clinically feasible concept with results similar to those for two-stage procedures, at least in good bone qualities. However, documentation of the outcome of immediate/early loading in the totally edentulous maxilla is scarce. PURPOSE The present investigation was undertaken to evaluate the outcome over 1 year of oxidized titanium implants when loaded with a fixed full-arch bridge in the maxilla 1 to 9 days after implant placement. MATERIALS AND METHODS Ten patients with totally edentulous maxillas were treated with 61 oxidized titanium implants, and a provisional fixed bridge was delivered after 1 to 9 days (mean 2.5 d). Nine patients had six implants and one patient had eight implants supporting the bridge. The provisional bridge was replaced with a permanent bridge after 2 to 7 months (mean 4.1 mo) of loading. Resonance frequency analysis (RFA) for implant stability measurements was made at implant placement in eight patients and in conjunction with permanent bridge connection in five patients. The patients were followed up for 1 year with clinical and radiographic examinations. RESULTS Four implants (6.6%) were lost in one patient after 10 weeks of loading owing to an infection. All other implants were clinically stable with a mean marginal bone loss of 1.3 +/- 0.6 mm after 1 year of loading. RFA showed a mean primary stability of 60.1 +/- 3.6 ISQ (implant stability quotient), which increased to 62.8 +/- 1.6 ISQ after, on average, 4 months. CONCLUSIONS The results from this limited study on 10 cases indicate that early loading protocols can be applied for cross-arch dental bridges supported by six to eight implants in the maxilla. However, more clinical trials are needed to establish the long-term predictability of the treatment.
The impact of knowledge management infrastructure on organisational competitiveness in a Confucian-socialist market economy

The critical role of knowledge management (KM) in achieving and sustaining a competitive advantage (CA) has been strongly emphasised in the extant literature. However, most previous studies were conceptually grounded and empirically examined in advanced, developed and newly industrialised countries and from a large company perspective. Meanwhile, little attempt has been made to address the relative importance of different factors constituting the organisational KM infrastructure capability in the context of Asian emerging, less developed countries such as Vietnam where a socialist market economy, a Confucian culture and a majority of small and medium sized enterprises currently exist. By adopting a resource-based theory of the firm with an extension of a knowledge-based perspective, this paper aims at developing and empirically validating a conceptual model of the relationships between KM infrastructure capability components and their impacts on a firmpsilas CA in Vietnam. The results of 148 surveyed respondents in the construction industry reconfirmed a general agreement found in the literature that a combined social and technological approach is ideal to take advantage of their significant positive correlations in improving organisational competitiveness. Moreover, in the Vietnamese-specific context, the study indicated that while culture is the most important issue affecting KM, integration with information technology may assist to overcome cultural barriers and provide a stronger contribution to a firmpsilas CA.
Analysis of antigenic variation in equine 2 influenza A viruses.

Influenza outbreaks involving viruses of the H3N8 subtype (equine 2) often occur in vaccinated horses. For this reason, a series of influenza viruses of the H3N8 subtype were examined to determine if antigenic variation could be detected in isolates during the period 1963-81. Antigenic analyses with post-infection ferret sera and monoclonal antibodies showed that the haemagglutinins of recent isolates were antigenically distinguishable from the prototype A/eq/Miami/1/63 and that antigenically distinguishable groups of equine 2 viruses co-circulate in the horse population. Based on these studies, it is recommended that a recent equine strain, A/equine/Fontainebleu/1/79 or A/equine/Kentucky/1/81, serve as an additional prototype strain for this subtype.Antigenic variation in equine 2 viruses may be of epidemiological significance, yet the overall conservation of these strains makes it unlikely that vaccine failures can be attributed solely to antigenic changes in these viruses. A sufficiently potent vaccine, containing a current representative of the most prevalent equine 2 strain, may improve the protection afforded by equine vaccines.
La conceptualización de la guerra en el discurso político Americano, Británico, Francés y Español

En el campo de la Linguistica, es evidente que el Analisis Critico del Discurso es una de las areas de estudio que se ha desarrollado mucho en las ultimas decadas. Este tipo de analisis trata de varias categorias de discursos; sin embargo, uno de los mas fundamentales es el analisis de los discursos politicos. Los analistas que participan en el analisis del discurso politico a menudo tienen que estudiar una amplia gama de datos linguisticos y no linguisticos que interactuan, ya sea en el habla o en la escritura. Uno de los datos linguisticos que emerge del estudio del discurso politico es el de las metaforas utilizadas para conceptualizar y por lo tanto expresar nociones especificas. El analisis de las metaforas es tambien objeto de estudio de la presente tesis. Mas concretamente, en esta tesis nos centramos en las metaforas que aparecieron en los discursos de los politicos durante la Segunda Guerra del Golfo Persico. La Segunda Guerra en Irak comenzo en 2003 y duro hasta 2011. Muchos paises participaron en la invasion de Irak, con el objetivo de desarmar al dictador iraqui de la epoca, Saddam Hussein. La longevidad de la guerra combinada con las diversas posiciones politicas de los politicos de los paises occidentales genero una gran cantidad de discursos, que en la presente investigacion se utilizaron para formar el corpus.