Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression and localization of insulin receptors in dissociated primary cultures of rat Schwann cells

The objective of the present study was to examine for the presence of the IRs (insulin receptors) in the primary dissociated culture preparation of SCs (Schwann cells). This was achieved using immunological techniques using a rabbit polyclonal anti‐IR antibody and at molecular level by RT (reverse transcription)‐PCR. Light microscopic immune cytochemistry revealed that almost all SCs in cluster and associated neuritis exhibited positive immune reaction with the antibody, confirming the presence of IRs in them. Immunoblotting detected a prominent protein band of 90 kDa, which is consistent with those reported by the manufacturer. Like the peripheral nerve, primary SC cultures showed a predominantly high affinity IR mRNA lacking exon 11. Ultrastructural immune localization confined the presence of the IRs in the basal lamina, plasma membrane and the cytoplasmic processes of the SCs.
Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients

Allogeneic hematopoietic cell transplantation is increasingly utilized in older adults. This study prospectively evaluated the prognostic utility of geriatric assessment domains prior to allogeneic transplantation in recipients aged 50 years and over. Geriatric assessment was performed prior to transplant, and included validated measures across domains of function and disability, comorbidity, frailty, mental health, nutritional status, and systemic inflammation. A total of 203 patients completed geriatric assessment and underwent transplant. Median age was 58 years (range 50–73). After adjusting for established prognostic factors, limitations in instrumental activities of daily living (HR 2.38, 95%CI: 1.59–3.56; P<0.001), slow walk speed (HR 1.80, 95%CI: 1.14–2.83; P=0.01), high comorbidity by hematopoietic cell transplantation-specific comorbidity index (HR 1.56, 95%CI: 1.07–2.28; P=0.02), low mental health by short-form-36 mental component summary (HR 1.67, 95%CI: 1.13–2.48; P=0.01), and elevated serum C-reactive protein (HR 2.51, 95%CI: 1.54–4.09; P<0.001) were significantly associated with inferior overall survival. These associations were more pronounced in the cohort 60 years and over. Geriatric assessment measures confer independent prognostic utility in older allogeneic transplant recipients. Implementation of geriatric assessment prior to allogeneic transplantation may aid appropriate selection of older adults.
Modelling the simultaneous effects of intellectual capital and knowledge management on the organisational performance of Finnish companies

Author: Kalle Eerikainen Subject: Modelling the simultaneous effects of intellectual capital and knowledge management on the organisational performance of Finnish companies Year: 2015 Place: Lappeenranta, Finland Master’s Thesis Lappeenranta University of Technology, School of Business and Management, Information and Knowledge Management Examiners: Professor Aino Kianto and Post-doctoral Researcher Mika Vanhala 69 pages, 8 figures, 5 tables and 5 appendices
A Security Model for Preserving the Privacy of Medical Big Data in a Healthcare Cloud Using a Fog Computing Facility With Pairing-Based Cryptography

Nowadays, telemedicine is an emerging healthcare service where the healthcare professionals can diagnose, evaluate, and treat a patient using telecommunication technology. To diagnose and evaluate a patient, the healthcare professionals need to access the electronic medical record (EMR) of the patient, which might contain huge multimedia big data including X-rays, ultrasounds, CT scans, and MRI reports. For efficient access and supporting mobility for both the healthcare professionals as well as the patients, the EMR needs to be kept in big data storage in the healthcare cloud. In spite of the popularity of the healthcare cloud, it faces different security issues; for instance, data theft attacks are considered to be one of the most serious security breaches of healthcare data in the cloud. In this paper, the main focus has been given to secure healthcare private data in the cloud using a fog computing facility. To this end, a tri-party one-round authenticated key agreement protocol has been proposed based on the bilinear pairing cryptography that can generate a session key among the participants and communicate among them securely. Finally, the private healthcare data are accessed and stored securely by implementing a decoy technique.
Research on college teachers' multi-duty principal-agent problem between teaching with scientific study

Monitoring the quality of teaching is difficult than measuring the scientific research quality with the university teachers.Among the multi-agency task, the college teachers have the personal hideaway information, so improving the quality of teaching and scientific research have the active vicariousness.Economics models can be used to analyze information in order to encourage the study of reasonable ways and means,and through reforming the existing performance evaluation and salary management system, incentives for re-engineering to achieve the interests of the teacher-oriented behavior.
Organisational commitment among software developers

If software developers are to be taken as prototypes of the new knowledge worker, we need look no further for working hypotheses about their attachment to their work and their employing organization than those contained in the human resource management agenda. For the diffusion of information and communication technologies (ICTs) as the supposed base of the knowledge economy has been synchronous with the launch and promotion of human resource management (HRM) as the new orthodoxy in employment practice and many of the assumptions and values within each model are shared. Indeed, HRM is often portrayed as if it were in some way a reflection of the shift to non-adversarial work relationships in the new information-based service society (Baldry 2003).
Exploring Marketing Strategies in Small Businesses

According to the Small Business Administration, there are approximately 23 million small businesses in the United States. Over 86% of businesses have no more than 20 employees, although the total number of people employed is approximately one-fourth of the entire United States workforce. Nearly 50% of all small businesses close within the first five years. The purpose of this qualitative case study was to understand the decisions and actions a small business owner takes when pursuing marketing strategy. Five findings emerged from the in-depth interviews: marketing, formulating strategy, strengths, values, and needs.
Enterprise Characteristics and Constraints in Developing Countries

There is currently a general consensus that enterprise promotion and growth constitute one of the viable strategies for achieving national development goals such as economic development and poverty alleviation. With various forms of support, enterprises are likely to improve their productivity and competitiveness, make a greater contribution to generating wealth and alleviating poverty among families of owners and workers alike, and create more jobs. Using data from a survey of 136 micro and small-scale enterprises (MSEs) in Tanzania, this paper examines enterprise characteristics and identifies a number of external constraints that influence enterprise growth. Based on the identified constraints the paper highlights a number of policy measures that may be relevant to the formulation of supportive programmes for MSE growth in Tanzania, and indeed other developing countries. This contribution probably comes at a critical moment when the Tanzanian government is in the process of developing a number of programmes to promote the MSE sector.
Top management commitment and involvement and their link to key account management effectiveness

Purpose – The purpose of the study is to examine the role of top management in effective key account management (KAM) relationships, making a distinction between top management commitment and top management involvement. Design/methodology/approach – The study uses data from 304 suppliers from different sectors to test the research model and hypotheses developed. Data were collected by means of personal interviews. The survey instrument was a structured questionnaire. Findings – Results show that top management commitment positively affects top management involvement. In addition, top management involvement totally mediates the relationship between top management commitment and relationship quality. Finally, relationship quality positively relates to financial performance. Research limitations/implications – The study focuses on the role of top management in KAM. Future research that considers the top management’s role simultaneously with other internal or external factors would provide a more comprehensiv.
Some clinical aspects of migraine. A prospective survey of 500 patients.

THE OBJECTS of the present study were to ascertain the following facts. The first objective was to ascertain the frequency of epilepsy (and other impairment of consciousness), allergic disturbances, and childhood vomiting attacks in migrainous patients, compared with patients suffering from tension headache. Kinnier Wilson 1 quotes 22 papers which had appeared up to 1932 discussing the relationship between epilepsy and migraine. Lennox and Lennox 2 found that 6.5% of 415 patients presenting with the symptoms of migraine were also epileptic. In 1960 a retrospective analysis was made of 500 patients with migraine at a neurological clinic by Selby and Lance, 3 who found that 4.5% of 396 migrainous patients were subject to major seizures at the time of their migraine attacks. Another 14% reported some disturbance of consciousness such as syncope or confusion. It is possible that these figures may have been biased by the fact that patients
Short-term load forecasting: Multi-level wavelet neural networks with holiday corrections

Short-term load forecasting plays a central role in reliable system operation by Independent System Operators and in making prudent bid decisions by market participants. Accurate forecasting is difficult in view of the complicated effects on load by various factors. In addition, it is difficult to forecast holidays as well as the days before and the days after in view of their particular load patterns and very limited data. In this paper, a multi-level wavelet neural network method is developed to forecast tomorrow's load. To effectively forecast the load for holidays as well as the days before and the days after, a correction coefficient scheme with holiday grouping is developed. Numerical results for a simple example and for Midwest-ISO's load demonstrate the effectiveness of multi-level wavelet neural networks, correction coefficients, and holiday grouping.
Music and pattern change in chronic pain

The purpose of this study was to investigate the use of music as a unitary–transformative means of altering the perception of chronic pain among women with rheumatoid arthritis within the context of Newman's model of health as expanding consciousness. In this repeated measures investigation, 30 women diagnosed with rheumatoid arthritis for a minimum of 6 months, responded to the McGill Pain Questionnaire prior to listening to music of their choice, during music, and 1 to 2 hours after completing the intervention. Data were analyzed according to the Number of Words Chosen (NWC) and the Pain Rating Index–Rank [PRI(R)] of the McGill Pain Questionnaire. The results of this study support the use of music as a unitary–transformative intervention.
An exploration of supply chain structure in Korean companies

A supply chain's structure describes the processes that control and co-ordinate the objectives and activities of independent organisational units that comprise the supply chain. This research explores supply chain structures based on case studies of Korean automobile, semiconductor and tyre manufacturing firms. The study found that the supply chain structures of the three product families are different from one another. Based on the case studies, we propose that supply chain structures can be classified as supply network dominated, conversion network dominated, or distribution network dominated. Factors that are likely to influence the supply chain structure are identified and discussed.
Mobile banking: proposition of an integrated adoption intention framework

Purpose – This paper's objective is to propose an integrated framework to investigate the adoption intention of mobile banking technology and to test it in the Brazilian context.Design/methodology/approach – A total of 666 respondents from the most economically developed cities in Brazil were surveyed. The sample comprised 333 mobile banking users and 333 mobile banking non‐users. Partial least squares was used to analyze the proposed framework's construct relations.Findings – The framework offers an integrated view, taking into account more predictors than other studies on the adoption of innovations. For non‐users, the framework was able to explain approximately 69 percent of the dependent variable (intention to adopt mobile banking) variation, which is a figure higher than those obtained in previous studies. However, for current users of mobile banking, only 27 percent of the dependent variable variation was explained by the framework. It was also observed that the predictors' influence over the criter.
HORSES FOR COURSES: WEBSITE SOPHISTICATION OF SME EXPORTERS

Websites are a particularly important marketing communication tool for SMEs which export. This paper addresses issues with previous research by employing a measure of the level of sophistication of websites and deriving potential influencing factors from previous literature and qualitative analysis of 25 case studies. A sample of 130 SMEs show varying levels of website sophistication and multivariate regression identifies a number of significant influences. Factors that positively affect the level of sophistication of websites include ICT knowledge, environmental pressure, entrepreneurship orientation and relative advantage. Time constraints imposed by staff workloads are a constraining (negative) factor. Implications for firms, policy makers and future research are outlined.
Tranexamic Acid Use in United States Trauma Centers: A National Survey

Tranexamic acid (TXA) is an antifibrinolytic agent that is listed as an essential medication by the World Health Organization for traumatic hemorrhage. We determined United States–based surgeons’ familiarity with TXA and their use of TXA. An online survey was sent to the 1291 attending surgeon members of a national trauma organization. The survey was organized into three general parts: respondent demographics, perceptions of TXA, and experience with TXA. The survey was completed by 35 per cent of members. TXA was available at 89.1 per cent of centers. Experience with TXA was variable: 38.0 per cent use regularly, 24.9 per cent use it 1 to 2 times per year, 12.3 per cent use it rarely, and 24.7 per cent had never used it. Among surgeons who had used TXA, 77.1 per cent noted that TXA had reduced bleeding, but 22.9 per cent indicated that it had not. Reasons for not routinely using TXA included uncertain clinical benefit (47.7%) and unfamiliarity (31.5%). Finally, 90.5 per cent of respondents indicated that are looking toward national organizations to develop practice guidelines. TXA is widely available in civilian United States trauma centers. Although a majority of surveyed surgeons had used TXA, only 38 per cent use TXA regularly for significant traumatic hemorrhage; principal reasons for this are uncertainty regarding clinical benefit and unfamiliarity with the drug. National guidelines are sought.
Continued Development of the Family Management Style Framework

Based on a review of 64 published reports, this article addresses the implications of current research for the further development of the Family Management Style Framework (FMSF). Articles are published in 46 different journals, including 13 in nursing and 12 in interdisciplinary outlets. Most studies are based on samples of less than 50 individuals. The review provides continuing support for the 8 dimensions of the framework, with between 8 and 16 reports supporting the relevance of each. Changes to the sociocultural component of the framework are proposed as well as wording changes to reflect the broader applicability of the framework. The family’s social network, health care and education professionals, and resources predominate as key influences on family management.
Managing in-store logistics: a fresh perspective on retail service

Purpose – Traditional retailers still insist on using price, product, and promotion as sources of competitive advantage. This emphasis typically ignores the potential of in‐store logistics operations in the creation of customer value. A major objective of retail customers is to navigate the retail servicescape in an efficient, convenient, enjoyable and effective manner. In‐store logistics operations largely determine how and to what extent the customer may achieve this objective. However, customer‐perceived indicators of in‐store logistics performance, such as product returns, order information, opening hours, and product availability and accessibility, have been largely ignored in research on retail service. The purpose of this paper is to investigate the role of in‐store logistics in determining customer outcomes such as store image, satisfaction and loyalty intentions.Design/methodology/approach – A model is developed based on extant research in the areas of logistics service quality, service logic, st.
Nonparametric Estimation of the Cyclic Cross Spectrum

Cyclostationary processes are an important class of nonstationary processes. We consider nonparametric estimation of the cyclic cross spectrum. A smoothed periodogram-based estimator is studied and its asymptotic behavior characterized, extending univariate work to the multivariate case. Application to cyclic coherence measurements is discussed. The results are useful in a variety of multisensor cyclostationary signal processing scenarios such as time delay and bearing estimation.
Evolution of the Human Immunodeficiency Virus Type 1 Envelope during Infection Reveals Molecular Corollaries of Specificity for Coreceptor Utilization and AIDS Pathogenesis

ABSTRACT The evolution of human immunodeficiency virus type 1 infection is associated with a shift in the target cell population, driven by variability in coreceptor utilization resulting from diversity inenv. To elucidate the potential consequences of these changes for Env-mediated fusion over the course of AIDS, we examined the biological properties of serial viral isolates and determined coreceptor utilization by the products of env cloned from two individuals, followed from the detection of seroconversion throughout the course of their infection. One had a typical course, and the other had an accelerated progression. Early isolates were non-syncytium inducing, and the corresponding Env exclusively utilized CCR5, whereas Env from late phases of infection showed restricted utilization of CXCR4 in both patients. Env from subject SC24, who had a standard progression, demonstrated multitropism, manifested by utilization of CCR3, CXCR4, and CCR5 in the intervening period. In contrast, Env from patient SC51, who experienced early conversion to the syncytium-inducing phenotype, developed dualtropic coreceptor utilization of CCR5 and CXCR4. Genetic analysis of env from each isolate revealed that those with an X4 phenotype formed a distinct subcluster within each subject. Analysis of chimeras constructed from R5 and multispecific env from patient SC24 demonstrated that while the V3 domain played a dominant role in determining coreceptor utilization, sequences in the V4–V5 region also contributed to the latter phenotype. Immunoprecipitation experiments confirmed that the hybrid Env proteins were expressed at similar levels. These experiments demonstrate that progression from the R5 to X4 phenotype may occur through a multi- or dual-tropic intermediate and that multiple domains contribute to this process.
Impact of human resource interventions on quality of work life: An exploration

Maintaining the quality of such human inputs is essential for the competitive advantage and sustainability of business organisations. Therefore, organisations are required to adopt a strategy to improve the quality of work life (QWL) of employees in order to satisfy both organisational objectives and employee needs. QWL creates a sense of fulfilment in the minds of employees and contributes to greater job satisfaction, improving productivity, adaptability and the overall effectiveness of an organisation. This paper reviews the meaning of QWL and focuses on the factors influencing QWL based on past research. It also suggests various HR interventions that need to be practised effectively to improve the quality of work life of employees.
Correlates of early disability in Huntington's disease

Functional disability in Huntington's disease usually results from a combination of the movement disorder, intellectual decline, and psychopathological changes, but the unique contribution of each element has never been investigated. The Shoulson‐Fahn functional capacity rating scale measures independence in such daily activities as eating, dressing, and managing personal finances, and is used to stage the illness and follow its progression. To determine which problems contribute most to reduced functional capacity as the disease evolves, we reviewed the records of 48 consecutive patients who were evaluated for intellectual and emotional status and motor disability. Each patient was staged and rated for functional capacity at the time of the examinations. Thirty‐three of these patients were followed over several years with repeat evaluations at 6‐month intervals. Intellectual impairment and depression correlated significantly with reduced functional capacity. However, when the somatic symptoms of depression were eliminated from the analysis, its relationship to functional capacity was no longer significant. Duration of illness, motor disability, and age at onset also had little impact. Neuropsychological test performance and functional capacity deteriorated over time. Our data suggest that intellectual impairment is a major factor in reducing functional capacity in the early stages of Huntington's disease.
The Political Economy of Downzoning

“Substantial downzoning” is defined as the exercise of police power to significantly reduce the legally permitted density on undeveloped land in a community. This contentious practice is typically challenged by those who perceive the action to limit their market opportunities (e.g., farmers and developers), their sympathizers, and others who prefer the status quo. Supporters tend to be those who perceive positive benefits (e.g., environmentalists, conservationists, and homeowners) and those who see it as a supplement to other preservation techniques, based on concerns over such things as growing public costs of land acquisition, limited effectiveness of existing alternatives, or the perceived urgency to act to manage growth. Given the complexity of the issue and the lack of previous research, this paper develops a conceptual model of the public choice to “substantially downzone” and presents specific hypotheses to be empirically tested, using New Jersey as a case study. The probability of implementing substantial downzoning is found to increase with (i) the amount of open space that remains to be protected, (ii) declining farm population, (iii) recent growth in non-farm population, (iv) recent growth in land values, and (v) the presence of alternative growth management tools. Results also suggest its use as a substitute for other preservation tools when the financial and/or political ability of communities to afford other approaches is limited. Hence, the likelihood of substantial downzoning may increase over time if alternatives become more difficult to implement.