Miracle-dz/UniFAR-FTUs huggingface dataset:
Complication, survival rates, and risk factors of surgery for metastatic disease of the spine.

STUDY DESIGN The risk factors for complications and complication and survival rates in patients with metastatic disease of the spine were reviewed. A retrospective study was performed. OBJECTIVES To determine the surgical complication and survival rates of patients with metastatic disease of the spine and risk factors for complication occurrence. SUMMARY OF BACKGROUND DATA The role of surgical intervention for patients with metastatic disease of the spine has been controversial. Several risk factors for surgical complications have been identified. Short survival times and high complication rates have failed to justify surgical intervention in many cases. METHODS Patients (n = 80) undergoing surgical treatment for metastatic disease of the spine were reviewed. Surgical indications included progressive neurologic deficit, neurologic deficit failing to respond to, or progressing after, radiation treatment; intractable pain; radioresistant tumors; or the need for histologic diagnosis. Patients underwent anterior, posterior, or combined decompression and stabilization procedures. Neurologic examination was recorded before surgery, postoperative period, and at least follow-up. Complication and survival rates were calculated. Several variables were examined for risk of complication. RESULTS The mean age at time of surgery was 55.6 years (range, 20-84 years). Mean survival time after the diagnosis of spinal metastasis was 26.0 months (range, 1-107.25 months). Mean survival time after surgery was 15.9 months (range, 0.25-55.5 months). Sixty-five patients showed no change in Frankel grade, 19 improved one Frankel grade, and 1 deteriorated one Frankel grade; 1 patient had paraplegia. Thirty-five complications occurred in 20 patients (25.0%). Ten patients (12.5%) had multiple complications accounting for 23 of the 35 postoperative problems (65.7%). Sixty patients had no surgical complications (75%). There were no intraoperative deaths. CONCLUSIONS The likelihood that a complication occurred was significantly related to Harrington classifications demonstrating significant neurologic deficits and the use of preoperative radiation therapy. In general, Harrington classifications with neurologic deficits and lower Frankel grades before and after surgery were associated with an increased risk of complication. Overall, the major complication rate was relatively low, and minor complications were successfully treated with minimal morbidity. The relatively long survival time after spinal surgery in this group of patients justifies surgical treatment for metastatic disease. Most complications occurred in a small percentage of patients. To minimize complications, patients must be carefully selected based on expected length of survival, the use of radiation therapy, presence of neurologic deficit, and impending spinal instability or collapse caused by bone destruction.
Antecedents of knowledge sharing and employee innovativeness

Previous researchers have acknowledged that the success of a firm’s innovation capability depends greatly on knowledge sharing. Numerous studies have examined individual factors affecting knowledge sharing and innovation capability. A review of the literature has unveiled the individual factors focusing on trust, enjoyment in helping others, self-efficacy, reciprocity, pro-sharing norms, self-image and organizational reward. However, other essential variables relating to attitudinal and behavioral factors have been neglected. In order to fill this gap, four factors namely job satisfaction, organizational commitment, organizational citizenship behaviour, and employee engagement are crucial for employees to engage in knowledge sharing to enhance their innovativeness incorporated into the research model. In the attempt to empirically validate this model, data were collected from engineers working with Malaysian manufacturing firms. Data were statistically analyzed by the structural equation modeling (SEM) technique using the SmartPLS software. The findings suggest that job satisfaction, organizational citizenship behaviour and employee engagement have significant influence on knowledge sharing. Furthermore, job satisfaction, organizational commitment and organization citizenship behaviour were found to have significant influence on employee innovativeness. Importantly, knowledge sharing mediated the relationship between job satisfaction, organizational citizenship behaviour and employee engagement with employee innovativeness. The implication of this study is that satisfied and engaged employees with good citizenship behaviour would foster knowledge sharing which in turn enhances their innovativeness. Further empirical validation or incorporation of new variables is recommended to extend this current study.
The prevalence and clinicopathological profile of IgM nephropathy in children with steroid-resistant nephrotic syndrome at a single centre in Pakistan

Background There is little information on the clinicopathological characteristics of IgM nephropathy (IgMN) in paediatric steroid-resistant nephrotic syndrome (SRNS) and its response to calcineurin inhibitors (CNI). Material and Methods This study was conducted at Sindh Institute of Urology and Transplantation, from January 2009 to August 2011. All SRNS children who received renal biopsies were included. Relevant data were compared among minimal change disease (MCD) and IgMN. The response to CNI was analysed in detail in IgMN by groups (group 1: complete or partial remission; group 2: no response). Results The frequency of IgMN in 147 children with SRNS was 13.6%. Compared with MCD, there was a male preponderance in IgMN. Blood urea and serum creatinine both at presentation and at last follow-up were significantly higher in IgMN. Regarding subgroups of IgMN, systolic blood pressure (SBP), blood urea and serum creatinine were significantly higher in group 2 at presentation, while at last follow-up, SBP, diastolic blood pressure and proteinuria were higher in group 2. The prevalence and degree of mesangial proliferation, global glomerulosclerosis, interstitial fibrosis and tubular atrophy were significantly higher in group 2. Conclusions IgMN is a common cause of paediatric SRNS and is significantly different from MCD. There is also a significant difference in clinical and laboratory parameters among responders and non-responders to CNI in IgMN.
Controlling shareholders, audit committee characteristics, and related party transaction disclosure: Evidence from Indonesia

The disclosure of related party transactions was required in the financial statements because it is potentially misused by controlling shareholders. This study aims to examine controlling shareholders, audit committee characteristics, and related party transaction disclosure. The controlling shareholders are proxied by the family share ownership and the proportion of the controlling shareholder family members on the board of directors. The samples used in this study are family companies listed on the Indonesia Stock Exchange (IDX) in the year 2017. In this study, the multiple regressions were used to test the hypothesis. We found that controlling shareholders have a negative influence on related party transaction disclosure. Meanwhile, accounting expertise of the audit committee has a positive influence on related party transaction disclosure. Our result show companies that controlled by the family have low motivation to disclose related party transaction disclosure. However, accounting expertise audit committee may encourage companies to disclose related party transactions. JEL Classifications : G32, G34 DOI : https://doi.org/10.26905/jkdp.v23i1. 2701
Angiopoietin-1 Induces Krüppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2*♦

Angiopoietin-1 (Ang1) regulates both vascular quiescence and angiogenesis through the receptor tyrosine kinase Tie2. We and another group have recently shown that Ang1 and Tie2 form distinct signaling complexes at cell-cell and cell-matrix contacts and further demonstrated that the former selectively induces expression of Krüppel-like factor 2 (KLF2), a transcription factor involved in vascular quiescence. Here, we investigated the mechanism of how Ang1/Tie2 signal induces KLF2 expression to clarify the role of KLF2 in Ang1/Tie2 signal-mediated vascular quiescence. Ang1 stimulated KLF2 promoter-driven reporter gene expression in endothelial cells, whereas it failed when a myocyte enhancer factor 2 (MEF2)-binding site of KLF2 promoter was mutated. Depletion of MEF2 by siRNAs abolished Ang1-induced KLF2 expression, indicating the requirement of MEF2 in KLF2 induction by Ang1. Constitutive active phosphoinositide 3-kinase (PI3K) and AKT increased the MEF2-dependent reporter gene expression by enhancing its transcriptional activity and stimulated the KLF2 promoter activity cooperatively with MEF2. Consistently, inhibition of either PI3K or AKT and depletion of AKT abrogated Ang1-induced KLF2 expression. In addition, we confirmed the dispensability of extracellular signal-regulated kinase 5 (ERK5) for Ang1-induced KLF2 expression. Furthermore, depletion of KLF2 resulted in the loss of the inhibitory effect of Ang1 on vascular endothelial growth factor (VEGF)-mediated expression of vascular cell adhesion molecule-1 in endothelial cells and VEGF-mediated monocyte adhesion to endothelial cells. Collectively, these findings indicate that Ang1/Tie2 signal stimulates transcriptional activity of MEF2 through a PI3K/AKT pathway to induce KLF2 expression, which may counteract VEGF-mediated inflammatory responses.
RESIDENTIAL HOUSING IN GHANA’S LOW-INCOME URBAN AREAS: AN ANALYSIS OF HOUSEHOLDS LIVING CONDITIONS IN THE WA MUNICIPALITY

The study examined the housing conditions of households in residential units within the Wa Municipality of Ghana. The study employed mainly interviews and focus group discussions, with questionnaire survey as a complementary technique, drawing on concepts of households’ demand for housing. The analysis suggests that households’ choice of living spaces is influenced by income, rent values, facilities available and nature of the residential area. Generally, households are faced with several inadequacies in housing services, with those in the older residential areas living in very precarious conditions. The unavailability of housing facilities, or their poor state, is as a result of the absence of public infrastructure including access to good roads, water and drainage systems, as well as noncompliance with municipal by-laws. The nature of the housing challenge facing the municipality calls for a move away from conventional ways of addressing the problem to new and innovative means of regulating the housing sector, particularly disentangling the production of housing units from the contribution of good, safe and secure living spaces and domestic/municipal infrastructure to the wider social processes of equitable urban development, notably the provision of adequate portable water, sanitation and waste management services.
Acute Caffeine Ingestion on Performance in Young Judo Athletes.

PURPOSE To compare the acute effect of caffeine ingestion on performance in young judo athletes. METHOD In a randomized double-blind design, eighteen judo athletes (16.1 ± 1.4 yrs.) were evaluated on three nonconsecutive days. On the first day, the special judo fitness test (SJFT) was used as a control session. On the second day, the sample was randomly divided into two equal groups. One group received 4 mg.kg-1 of caffeine (capsule) and the other group received a placebo. After resting for 60 min, the sample performed the SJFT. On the final day of testing, the same procedure was performed but the substance ingested was exchanged between the groups. RESULTS Heart rate (HR) and rating of perceived exertion (RPE) were recorded throughout the applications of the SJFTs. Caffeine ingestion did not induce changes in HR, but reduced the RPE compared with the placebo session (7.0 ± 1.1 vs 8.2 ± 2.0; p < .05), increased the number of throws applied (29.0 ± 2.6 vs 22.1 ± 3.4; p < .01) and reduced the SJFT index (12.2 ± 0.5 vs. 15.7 ± 0.9; p < .001). CONCLUSION 4 mg.kg-1 did not alter HR but improved performance on SJFT in young judo athletes and reduced the RPE.
Influence of Fundamental Factors on Dividend Payout Policy: Study on Construction Companies Listed on Indonesian Stock Exchange

This study examines the fundamental factors that influence the dividend payout policy, namely leverage, liquidity, free cash flow, firm size, firm growth, business risk and profitability. Several previous research results indicate differences in research findings. This study was conducted on five construction contractor companies listed in Indonesia Stock Exchange during 2010 to 2016. Multiple regression analysis was operated through SPSS 20 program and hypoteses testing simultaneously with F-test and partially with t-test. The results show that all independent variable are important factors in dividend payout policy, and firm size is the most dominant factors affecting dividend payout policy.
CXCR 4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma

The support mechanisms that are involved in lymphnode metastasis of oral squamous cell carcinoma (OSCC) remain largely unknown. Recent studies have demonstrated that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans. In this study, we examined the expression and function of chemokines and their receptors in OSCC. The expression of chemokine receptors was assessed in eight OSCC cell lines. CXCR3 mRNA and protein were expressed in all the OSCC cell lines examined, while CXCR4 mRNA and protein were expressed only in HSC2, HSC3, and Ca9-22 cells. Treatment with the ligand for CXCR4, stromal cell-derived factor-1 (SDF-1), enhanced the motility and invasiveness of OSCC cells expressing CXCR4. However, the CXCR3 ligand, Mig, did not affect the migration or invasiveness of CXCR3-positive cells. We also evaluated the clinical significance of CXCR4 expression immunohistochemically. CXCR4 expression was detected in 27 (30%) of the 90 OSCC tissues tested, and was localized in the membrane and cytoplasm of cancer cells. There was a highly significant correlation between CXCR4 expression and lymph-node metastasis (P=0.0035). Collectively, these findings suggest that CXCR4 might be involved in the lymph-node metastasis of OSCC.
Hard X-ray emission from eta Carinae

Context. If relativistic particle acceleration takes place in colliding-wind binaries, hard X-rays and γ-rays are expected through inverse Compton emission, but to date these have never been unambiguously detected. Aims. To detect this emission, observations of η Carinae were performed with INTEGRAL, leveraging its high spatial resolution. Methods. Deep hard X-ray images of the region of η Car were constructed in several energy bands. Results. The hard X-ray emission previously detected by BeppoSax around η Car originates from at least 3 different point sources. The emission of η Car itself can be isolated for the first time, and its spectrum unambiguously analyzed. The X-ray emission of η Car in the 22–100 keV energy range is very hard (Γ � 1 ± 0.4) and its luminosity is 7 × 10 33 erg s −1 . Conclusions. The observed emission is in agreement with the predictions of inverse Compton models, and corresponds to about 0.1% of the energy available in the wind collision. η Car is expected to be detected in the GeV energy range.
Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance

In this study, we examined the mechanism of translation of the human immunodeficiency virus type 1 tat mRNA in eucaryotic cells. This mRNA contains the tat open reading frame (ORF), followed by rev and nef ORFs, but only the first ORF, encoding tat, is efficiently translated. Introduction of premature stop codons in the tat ORF resulted in efficient translation of the downstream rev ORF. We show that the degree of inhibition of translation of rev is proportional to the length of the upstream tat ORF. An upstream ORF spanning 84 nucleotides was predicted to inhibit 50% of the ribosomes from initiating translation at downstream AUGs. Interestingly, the distance between the upstream ORF and the start codon of the second ORF also played a role in efficiency of downstream translation initiation. It remains to be investigated if these conclusions relate to translation of mRNAs other than human immunodeficiency virus type 1 mRNAs. The strong inhibition of rev translation exerted by the presence of the tat ORF may reflect the different roles of Tat and Rev in the viral life cycle. Tat acts early to induce high production of all viral mRNAs. Rev induces a switch from the early to the late phase of the viral life cycle, resulting in production of viral structural proteins and virions. Premature Rev production may result in entrance into the late phase in the presence of suboptimal levels of viral mRNAs coding for structural proteins, resulting in inefficient virus production.
The Effects of Applicant Résumé Contents on Recruiters' Hiring Recommendations: The Mediating Roles of Recruiter Fit Perceptions

The resume is the most commonly used selection tool for organisations. Past studies have demonstrated that recruiter hiring recommendations can be predicted based on the content of applicant resumes. However, the mechanisms underlying the links between resume contents and hiring recommendations remain unclear. The present study extends previous research by examining the mediating roles of recruiters' multi-faceted fit perceptions in a field setting. Data were collected from 216 organisational recruiters who participated in campus recruitment at seven universities in Taiwan. The results showed that applicant work experience and educational background increased recruiter hiring recommendations through recruiter perceived person―job (P-J) fit. In addition, applicant work experience predicted recruiter perceived person―organisation (P-0) fit, which in turn enhanced recruiter hiring recommendations.
The Effects of Religiousity, Pricing and Corporate Image on The Attitude and The Intention to Use Sharia Micro Financing

The Developing of Micro, Small and Medium Enterprises (MSMEs) in Indonesia could not be separated from the support of banking system in bank credit disbursement to MSMEs sector. Mandiri Sharia Bank (BSM) is one of the sharia banks that had disbursed sharia micro financing (micro credit). The objective of this research was to analyze the influence of religiosity, pricing and corporate image toward the attitude and the intention to use sharia micro financing. This research, hopefully, could give recommendations of marketing strategies to increase the number of debtors to use sharia micro financing (micro credit). This research used 150 respondents that had been chosen purposively with some criteria, such as entrepreneurs (prospective customers) who have a company in MSMEs sector but they have never experienced using sharia micro financing. The data were analyzed using SEM with SmartPLS3 software. This is a quantitative research using a descriptive approach. The data of respondents were collected by face-to-face interview using a questionnaire tool. The result showed that pricing and corporate image through the attitude provided significant influence on the intention to use sharia micro financing. Meanwhile, the religiosity and corporate image provide insignificant influence on the intention to use sharia micro financing. The fixed pricing and good corporate image would increase the attitude and the intention to use sharia micro financial services.Keywords: MSMEs, SEM, intention to use, pricing, sharia micro financing
Low-dose radiation-induced risk in spermatogenesis

Abstract Purpose: To discuss low-dose radiation-induced risks to male fertility focusing on potential mechanisms of low-dose radiation-induced damage on spermatogenesis, epidemiological studies of environmental radiation effects on sperm parameters and transgenerational effects following exposure of spermatogonial stem cells (SSCs). Background: Spermatogenesis produces mature male gametes, spermatozoa, which fertilize their counterpart female gametes, oocytes. The robust maintenance system of spermatogenesis is essential for genomic conservation; however, male fertility can be readily impacted by exposure to environmental, chemical and physical factors including ionizing radiation. The mammalian testes are known to be radiosensitive yet the underlying molecular mechanisms of low-dose radiation-induced risks for spermatogenesis remain unclear. Furthermore, evidence characterizing transgenerational effects following exposure of SSCs remain controversial. Conclusions: Current concerns over the possible effects of low-dose radiation exposure on spermatogenesis requires further elucidation that may be resolved comparing and integrating observed experimental and epidemiological data.
Characterization and diagnostic evaluation of chronic polyneuropathies induced by oxaliplatin and docetaxel comparing skin biopsy to quantitative sensory testing and nerve conduction studies

Chemotherapy‐induced peripheral neuropathy negatively affects the quality of life for many patients treated with oxaliplatin or docetaxel for gastrointestinal cancer or breast cancer. Symptoms can persist long after treatment and often include neuropathic pain. Our objective was to characterize the neuropathies with regard to symptoms, neurological signs and objective evidence of damage to the structure and function of the peripheral nerves. Furthermore, the diagnostic values of skin biopsy, quantitative sensory testing (QST) and nerve conduction studies (NCS) were compared.
Cool and warm dust emission from M 33 (HerM33es)

In the framework of the open-time key program “Herschel M 33 extended survey (HerM33es)”, we study the far-infrared emission from the nearby spiral galaxy M 33 in order to investigate the physical properties of the dust such as its temperature and luminosity density across the galaxy. Taking advantage of the unique wavelength coverage (100, 160, 250, 350, and 500 μm) of the Herschel Space Observatory and complementing our dataset with Spitzer-IRAC 5.8 and 8 μm and Spitzer-MIPS 24 and 70 μm data, we construct temperature and luminosity density maps by fitting two modified blackbodies of a fixed emissivity index of 1.5. We find that the “cool” dust grains are heated to temperatures of between 11 K and 28 K, with the lowest temperatures being found in the outskirts of the galaxy and the highest ones both at the center and in the bright HII regions. The infrared/submillimeter total luminosity (5–1000 μm) is estimated to be 1.9 × 10^9 _(-4.4×10)^8^(+4.0×10)^8L_⊙. Fifty-nine percent of the total infrared/submillimeter luminosity of the galaxy is produced by the “cool” dust grains (~15 K), while the remaining 41% is produced by “warm” dust grains (~55 K). The ratio of the cool-to-warm dust luminosity is close to unity (within the computed uncertainties), throughout the galaxy, with the luminosity of the cool dust being slightly higher at the center than the outer parts of the galaxy. Decomposing the emission of the dust into two components (one emitted by the diffuse disk of the galaxy and one emitted by the spiral arms), we find that the fraction of the emission from the disk in the mid-infrared (24 μm) is 21%, while it gradually rises up to 57% in the submillimeter (500 μm). We find that the bulk of the luminosity comes from the spiral arm network that produces 70% of the total luminosity of the galaxy with the rest coming from the diffuse dust disk. The “cool” dust inside the disk is heated to temperatures in a narrow range between 18 K and 15 K (going from the center to the outer parts of the galaxy).