Miracle-dz/UniFAR-FTUs huggingface dataset:
Steady-StateNonlinearPharmacokinetics of 5-Fluorouracil duringHepatic Arterialand Intravenous Infusionsin CancerPatients1

Hepatic arterial catheters were placed for therapy in 8 patients with primary or metastatic liver cancer. Temporary hepatic ve nous catheters allowed direct sampling of blood for hepatic venous drug concentrations. Patients were administered from three to six infusions at rates of 10, 30, 90, 135, 180, 210, and 270 mg/kg/day (0.053 to 1.43 Â? Â? M/kg/min), given over 2 h, of 5fluorouracil (FUra). In Method 1, FUra was infused i.V. , and FUra was measured in plasma from hepatic arterial and hepatic venous blood. In Method 2, FUra was given i.v. at one time and infused into hepatic arterial blood at another time, and FUra was mea sured in plasma from peripheral blood at the same site in both cases. Steady-state FUra plasma concentrations were measured by a sensitive and specific high-performance liquid chromatography method. Data were computer fitted to the equations appropriate for a physiological two-compartment flow model with Michaelis-Menten elimination from the peripheral compartment and blood flow rate, 0, between the central and peripheral compartment. Methods 1 and 2 gave mean Vmaxand Kmvalues which did not differ significantly; the overall mean Vmax was 2.02 MM/kg/min, and the overall mean Kmwas 10.9 ^M. For Method 1 the mean Qi value was 0.0803 liters/(kg x min) or 5.26 liters/ min, which is the same as cardiac output, but for Method 2 the mean Q2 value was higher, namely 0.189 liters/(kg x min) or 13.0 liters/min. Steady-state systemic and intrinsic clearances and extraction ratios decreased progressively as the dose rate increased. Intra- and inter-subject variation of both Vmai< and Km were of the same order of magnitude. As a result, dose rate escalation should be conservative for dose rates above 135 mg/ kg/day. The results support hepatic arterial infusion as a means of improving the therapeutic index of FUra in the treatment of cancer of the liver.
Effect of Magnesium Sulphate on Cardiac Biomarkers in Pre-eclamptic Patients in Selected Tertiary Hospitals in Osun State South Western Nigeria

Aims: This study investigated the effect of magnesium sulphate (MgSO 4) on hepatic biomarkers in the management of pre-eclampsia in Osun State, Nigeria. This was with a view to providing scientific support for the use of MgSO 4 in the management of pre-eclampsia, and also to investigate likely adverse effects of MgSO 4 on the biological functions of the liver. Original Research Article
Information quality problems in Farsi web-based learning resources: how do teachers assure of the content quality for classroom use?

Although the Web has been seen as a critical source of information in K–12 education, Iranian educators’ acceptance for the web technology to become mainstream in the classroom remains a big challenge. Quality of information might be taken into account towards successful use of web-based learning resources. This study identifies the perceived information quality problems of Farsi web resources to be used in classroom instruction. This qualitative study employs focus group and interviews as the data collection technique, involving 10 secondary school teachers in Iran. It analyzed the information quality problems and information quality assurance applied or suggested by the participants in the context of web resources used in classroom instruction. Eleven dimensions of information quality problems emerged from the focus group discussion, seven of which are associated with content quality. Educators’ perceptions about the quality of web resources might be considered as critical in terms of usage of web resources in the Iranian school context. Not only the information quality dimensions highlighted in this study may help them, but also increased theoretical understanding can translate into practical insights that will benefit professionals who seek to design educational websites for credibility.
Computer vision for larval structures identification applied to forensic science.

The diptera maggots are used in forensic entomology to estimate the post-mortem interval (PMI). Maggots have a wide range of morphological and structural features that aid in the identification. In order to assist in the necrophagous larvae identification, this research aims to develop a software using computer vision and machine learning to automate the classification process. Diptera maggots were collected in a dead pig at the capital of Mato Grosso do Sul state, Campo Grande. The maggots were identified and photographed at a light microscope (5x objective). Next, the images were processed, the features extraction was performed using an extractor in Python language. The classification of the images were tested with AdaBoost, Random Forest, Random Tree and SMO classifiers. The SMO the best performa.
Alveolar Ridge Preservation of Maxillary Molars for Implant Placement Without Sinus Lift Surgery: Case series

Copyright © 2018. The Korean Academy of Oral & Maxillofacial Implantology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. OPEN ACCESS Sinus lif t procedure is f requently required for the maxillary molar implant placement. Previous studies have demonstrated alveolar ridge preservation (ARP) can maintain the dimensions of ridge height and width. However, there is a lack of studies which evaluated the effect of ARP to avoid sinus lif t procedure. Purpose of this study is to describe a method reducing the need of sinus lif t surgery by ARP in maxillary molar areas and to assess the feasibility clinically, radiologically and histologically. Ten maxillary molars in ten patients had severe vertical bone resorption with minimal residual bone height. They were considered having the high possibility of the necessity of sinus lif t procedure for dental implant af ter the extraction. After extraction, open healing ARP with deproteinized bovine bone mineral mixed with 10% collagen and resorbable collagen membranes was performed. After sufficient healing, dental implants were placed, and evaluated clinically and radiologically. Histological observation was conducted just before the implantation in one patient. Implants were successfully placed without sinus lift in all ten cases. All the implants were restored with no sign of complications, and patients are now in a close follow-up up to 20 months postloading. Histological observation showed minimal inflammatory reaction and newly formed bone was substantially noted. The ARP technique has successfully avoided the sinus lif t surgeries. It appears that this procedure may improve the simplicity of the clinical process for the clinicians and reduce the discomfort of patients. Abstract Case Report
Faktor-Faktor Yang Berhubungan Dengan Kejadian Kematian Maternal Di Solo Raya (Studi Kasus Di Rsud Dr. Moewardi Surakarta)

MMR in Indonesia is still quite high, amounting to 359 per 100,000 live births (IDHS 2012). AKI in Central Java in 2012 based on reports from county/city of 116.34/100,000 live births. Solo Raya is a region in Central Java with a fairly high maternal mortality. The purpose of this study was to determine the risk factors that influence the incidence of maternal mortality in Solo Raya years 2013-2015. This research method using analytic observational study design, the design or the design of case-control studies. This study population of 100 people, 50 cases and 50 controls. Data analysis was performed using univariate, bivariate with chi square test, multivariate multiple logistic regression method. The results of the bivariate analysis showed that the factors affecting maternal mortality is spaced pregnancies (p = 0.000) and the ANC examination (p = 0.014). While that is not a risk factor for maternal mortality is parity, where labor, and education. The results showed that the risk factors that influence maternal mortality by multivariate analysis were spaced pregnancies (p=0,001; OR=4,227; 95% CI=1,737 to 10,284).
Apprentissage machine orienté QoS pour l'accès opportuniste au spectre

Dans ce travail, nous nous interessons au probleme de l’apprentissage machine pour l’acces opportuniste au spectre (AOS). Nous presentons un nouvel algorithme d’apprentissage machine base sur la classe des UCB (Upper Confidence Bound). Cet algorithme permet non seulement d’apprendre les canaux qui sont le plus souvent libres mais egalement ceux qui possedent la meilleur qualite en terme de rapport signal a bruit (RSB), ce qui permet d’introduire une notion de qualite de service (QoS). La strategie proposee permet a un utilisateur secondaire de ponderer de maniere appropriee un critere particulier associe au canal qu’il choisit, comme la puissance d’emission ou le debit par exemple, en selectionnant deux coefficients d’explorations differents. Notre algorithme permet un compromis entre l’exploration et l’exploitation lorsque le scenario AOS est modelise comme un probleme Markovien de bandit manchot (BM) stable. Nous montrons que notre algorithme surpasse le traditionnel UCB1 en termes de regret et de choix du meilleur canal.
A clinical study of surgical management of diaphyseal fractures of shaft of femur in children and adolescents using flexible nails

Aim and Objective: In this study 20 patients, aged 5 to 16 years, with fracture shaft of the femur were treated with retrograde flexible intramedullary nailing at Bapuji Hospital and Chigateri General Hospital, attached to J.J.M. Medical College in the period from September 2013 to September 2015. Materials and Methods: The study includes patients with femoral shaft fractures admitted and examined according to protocol. Associated injuries were noted. Clinical and radiological investigations were carried out and medical fitness for surgery to undergo flexible nailing fixation for the sustained fracture was taken. Patients were followed up at 1,2,3,6 months intervals till fracture union and once at 1 year after surgery. A minimum of 20 cases were studied without any sampling procedure.
The Effectiveness of Tecar Therapy in Musculoskeletal Disorders

Objective: To evaluate the effectiveness of tecar therapy in musculoskeletal disorders. Methods: Computerized search in databases such as PubMed / Medline, Web of knowledge, Lilacs, Scielo, PEDro, RCAAP and Cochrane, to identify randomized controlled trials that evaluated the effectiveness of tecar therapy in musculoskeletal conditions. Results: Six articles, were included in this review, through the inclusion and exclusion criteria, where they were divided in four categories: low back pain, femur fracture, rotator cuff tendinopathy and delayed onset muscle soreness on the quadriceps. Conclusion: The tecar therapy is an excellent therapy for the physiotherapeutic use and it´s incorporation in a conventional rehabilitation program, or it´s isolated use, may have advantages in the short and long term effects.
Care Across Campus: Athletic Training, Nursing, and Occupational Therapy Student Experiences in an Interprofessional Simulation

This study explored health care students' experiences after participation in an interprofessional simulation. Interprofessional education incorporates students from several health care professions in a controlled, collaborative learning environment. Athletic training students are not well represented in interprofessional education literature. This study sought to explore the attitudes of athletic training, nursing, and occupational therapy students toward other professions after their participation in an interprofessional simulation. This article describes the results of the qualitative portion of a mixed-methods study. Focus group discussions related to elements of the Interprofessional Attitude Scale to explore participants' attitudes toward other professions. Researchers analyzed transcribed focus group discussions for themes. This study occurred in a private midsized Midwestern university. Seventy-nine students, representing athletic training, nursing, and occupational therapy, participated in the simulation; a sample of 13 of these participated in the focus groups. Students in all professions cared for or observed the care of a standardized patient from the time of a spinal cord injury on the football field through an ambulance ride and subsequent emergency and inpatient care. Students collaborated and communicated with one another. Faculty conducted debriefing after the simulation and before the focus groups. Focus groups included relevant questions from the Interprofessional Attitudes Scale, and themes were identified from participants' responses. Researchers identified 4 themes from the focus group discussions: collaboration, respect, knowledge of other professions, and communication. These themes also mirror elements of the Interprofessional Education Collaborative's core competencies of interprofessional collaborative practice. After the simulation, students expressed positive attitudes toward other professions. This study suggests that athletic training, nursing, and occupational therapy students have positive attitudes toward each other's professions after an interprofessional simulation activity.
Calidad de vida en adultos del Paraguay con enfermedad celiaca

La enfermedad celiaca altera el estado emocional, las relaciones sociales, la autonomia y la percepcion de la salud, afectando la calidad de vida relacionada a la salud. Los objetivos fueron determinar la calidad de vida relacionada a la salud en adolescentes y adultos con enfermedad celiaca e investigar los factores que la afectan. Se realizo un estudio observacional, prospectivo, realizado en adolescentes y adultos del Paraguay portadores de enfermedad celiaca con al menos 6 meses en dieta sin gluten. Se aplico el cuestionario CD-QOL. Fueron incluidos 114 sujetos, con edad media 30±10 anos, siendo 58% del sexo femenino. La calidad de vida fue buena en 25%, regular en 49% y mala en 26%. Los factores asociados significativamente a mejor calidad de vida fueron el sexo femenino, el grupo etario >30 anos y realizar actividades fuera del hogar. Se concluye que la calidad de vida de los celiacos adolescentes y adultos es regular en 49% de los encuestados.
Cambios bioquímicos relacionados con la percepción del dolor, la respuesta al estrés y el daño tisular asociados a una Manipulación Vertebral

espanolLa manipulacion vertebral (MV) es una tecnica ampliamente utilizada en el tratamiento del dolor de origen musculoesqueletico desde tiempos de Hipocrates. A pesar de su amplia utilizacion, aun no se conocen con certeza los mecanismos de accion. Asi mismo, aunque algunos clinicos han advertido de los posibles efectos adversos del uso de estas tecnicas, no hay estudios cientificos que corroboren o desmientan dicha afirmacion. El objetivo de esta investigacion es analizar y estudiar los posibles mecanismos por los que la tecnica es eficaz y determinar si la MV en si puede producir danos en los tejidos. Para ello se determinara la concentracion en sangre de mediadores quimicos relacionados con la analgesia, y de marcadores de dano tisular. Las mediciones se realizaran antes de, justo despues de, y a las dos horas de recibir una MV toracica, una MV cervical o no recibir intervencion EnglishSpinal manipulation (SM) is a common treatment approach for musculoskeletal pain disorder since Hippocrates. Nevertheless, even today the mechanisms through which SM alters musculoskeletal pain are still unknown. Additionally, even though several clinicians have alerted of possible adverse effects associated to the use of this technique, there are no evidence-base to neither support nor refute this affirmation. The aim of this study is to determine possible mechanisms through which SM is effective and if it can generate tissue damage. We’ll determine the chemical agents blood concentration related to analgesia and tissue damage. The measurements will be done before, after and two hours after a thoracic SM, cervical SM or no intervention.
Prevalence of Trachoma in Senegal: Results of Baseline Surveys in 17 Districts

ABSTRACT Purpose: Senegal is endemic for trachoma, an infectious and potentially blinding eye disease. To complete the country’s district-level baseline map of trachoma, we conducted population-based surveys in 17 health districts that were suspected-endemic but had yet to be surveyed. Methods: We randomly selected 30 clusters (villages) per district and 30 households per village, and estimated the district-level prevalences of trachomatous inflammation—follicular (TF) in children aged 1–9 years, and trichiasis in persons aged ≥15 years. Data on household-level water, sanitation, and hygiene variables were also collected. Global Trachoma Mapping Project methods were followed in training, fieldwork, and data handling. Results: 25,704 children aged 1–9 years and 30,345 adults aged 15 years and above were examined. In children aged 1–9 years, the prevalence of TF was <5% in all 17 districts, with the exception of Saint-Louis (5.1%, 95% CI 3.2–7.5). Trichiasis prevalence in participants aged 15 years and above ranged by district from 0%–1.1% (95% CI 0.7–1.5), with 9 districts having trichiasis prevalences above the elimination threshold of 0.2%. Trichiasis was seen to be significantly less frequent in males than in females (0.17% [95% CI 0.12–0.24] versus 0.49% [95% CI 0.38–0.61], p < 0.001). The prevalence of trichiasis rose steeply with age; 62% of cases were observed in people aged 55 years or above. Conclusions: Active trachoma is not a public health problem in 16 of the 17 surveyed districts, and implementation of the full Surgery (S) – Antibiotics (A) – Facial cleanliness (F) – Environmental improvement (E) strategy is not a programmatic priority. Increased provision of trichiasis surgery is warranted in nine districts.
Is homeopathic treatment more effective than giving time and attention to NHS patients with chronic complaints

Many people seek individualised homeopathic treatment, however its use remains controversial. There have been suggestions that any improvement of the symptoms of those seeking individualised homeopathic treatment is solely down to the time and attention given to the patient by the homeopath. This aim of this thesis is to explore the question “is homeopathic treatment involving a homeopathic consultation and a homeopathic remedy any different to spending time with an empathetic practitioner, in the treatment of irritable bowel syndrome? ” This study involved a systematic review of homeopathic treatment for irritable bowel syndrome and a randomised controlled trial comparing individualised homeopathic treatment to supportive listening and usual care. The primary outcome measure was the change in irritable bowel symptom severity score at 26 weeks. Differences between the three arms were assessed using independent t-tests and ANCOVA. A qualitative study nested within the randomised controlled trial involved qualitative interviews with a proportion of the participants in both the homeopathic treatment and supportive listening arms. This was to explore participants’ experiences of the treatment they received, and what, if anything about the treatment they felt led to any improvements. The systematic review of homeopathic treatment for irritable bowel syndrome identified two eligible RCTs, a meta-analysis of the results of these trials indicated a benefit of homeopathic treatment over placebo. However the results of this review should be viewed with caution as it is possible that there was a degree of bias associated with these two trials. In the randomised controlled trial, no significant differences were found between homeopathic treatment and supportive listening, when using t-tests or ANCOVA to compare mean change in IBS-SSS between baseline and 26 weeks. The qualitative interviews identified four different typologies that explained what patients believed to have led to changes in their general health and/or irritable bowel symptoms.
Modified Nutrition Risk in Critically Ill (mNUTRIC) Score to Assess Nutritional Risk in Mechanically Ventilated Patients: A Prospective Observational Study from the Pakistani Population

Purpose Typical nutritional assessment criteria and screening tools are ineffective in mechanically ventilated patients who are often unable to report their food intake history. The Nutrition Risk in Critically Ill (NUTRIC) score is effective for screening mechanically ventilated patients. This prospective observational study was conducted to identify nutritional risk in mechanically ventilated patients using a modified NUTRIC (mNUTRIC) score (without using interleukin-6 values). Methods All adult patients admitted to the intensive care unit (ICU) for more than 48 hours were included in the study. Data were collected on the variables required to calculate mNUTRIC scores. Patients with mNUTRIC scores ≥5 were considered at high nutritional risk. The assessment data included total ICU length of stay, ventilator-free days, and mortality rates. Results and conclusion A total of 75 patients fit the inclusion criteria of the study, including 40 males and 35 females. The mean age was 55.8 years. Forty-five percent of mechanically ventilated patients had mNUTRIC scores ≥5. Mechanically ventilated patients with mNUTRIC scores ≥5 had longer lengths of stay in the ICU (mean ± SD = 11.5±5 days) as compared with 3.5±4 days in patients with mNUTRIC scores ≤4. Moreover, a higher mortality rate (26%) was observed in patients with mNUTRIC scores ≥5. A high mNUTRIC predicted mortality score shows a receiver operating characteristic curve of 0.637 with a confidence interval between 0.399 and 0.875. Forty-five percent of mechanically ventilated patients admitted to the ICU were at nutritional risk, and their mNUTRIC scores were directly related to higher lengths of stay and mortality.
Changes in organ and body weight, serum amylase and antidiabetic effects of tannins from Spondias mombin on streptozotocin-induced diabetic rats

Background: Medicinal plants have been used for centuries in the management of chronic diseases including diabetes. Aim: The purpose of this study is to evaluate the possible antidiabetic effects and changes in serum amylase activities, body weight and organ weight of tannins from Spondias mombin on streptozotocin-induced diabetic rats. Setting: The study was conducted in the department of Biochemistry, University of Benin, Edo state, Nigeria. Methods: A total of 24 albino Wistar rats were divided into four groups (A through D). Group A served as the normal control. Diabetes was induced in rats of groups B, C and D by single-dose intraperitoneal administration of streptozotocin (65 mg/kg body weight) to overnight-fasted rats. Only rats with fasting blood glucose ≥ 250 mg/dL were used for this study. Isolated tannins (100 mg/kg body weight) were administered to rats of group D only. Blood glucose was monitored on Day 0, Day 3, Day 10 and Day 21. After 21 days experimental period blood samples were collected and used for serum amylase activities. Tissues (liver, pancreas, heart and kidney) were excised out and weighed. Results: Tannins-treated rats showed a significant increase in body weight and serum amylase activity when compared with the diabetic control. Also, a significant decrease in blood glucose level was seen in the tannins-treated rats when compared with the diabetic control. A significant decrease in the weight of the pancreas and a significant increase in the weight of the liver were seen in the diabetic control rats when compared with the tannins-treated groups. Conclusion: Tannins of Spondias mombin have an antidiabetic effect and can restore serum amylase and body weight changes resulting from streptozotocin induction.