Miracle-dz/UniFAR-FTUs huggingface dataset:
Epstein-Barr virus-related disorders in children undergoing renal transplantation with tacrolimus-based immunosuppression.

In children undergoing renal transplantation, Epstein-Barr virus- (EBV) related disorders, including posttransplant lymphoproliferative disorder, constitute a major complication associated with tacrolimus-based immunosuppression. In this study, we reviewed the EBV complications in 81 children, all of whom had EBV serological studies before renal transplantation. We also highlight the data in a subgroup of 30 children transplanted more recently who were monitored sequentially for EBV symptoms and signs and with immunological studies, and in whom the donor EBV serology was also determined. During a mean follow-up time of 3.9+/-2.3 years, 19 children developed symptomatic Epstein-Barr virus (EBV*) infection. This consisted of the clinical syndrome of infectious mononucleosis in 7 children; in addition, 10 children developed posttransplant lymphoproliferative disorder (PTLD), which was histologically confirmed in 8, and 2 others developed malignant lymphoma. Recipient seronegativity (EBV-) and donor EBV seropositivity (EBV+) predicted a high probability for seroconversion (P=0.0072) and for developing PTLD or malignancy (P<0.01). In the subgroup of 30 children studied prospectively, seroconversion occurred in 15 of 19 seronegative recipients of EBV seropositive grafts at 6.6+/-2.6 months (mean+/-SD) after transplantation. Seven children developed symptomatic EBV infection (including three with PTLD) in association with seroconversion and a rise in EBV viral load in the peripheral blood, demonstrated by an EBV-specific polymerase chain reaction (EBV-PCR). Of 15 seroconverters, 7 who developed symptomatic infection had received EBV+ grafts; 8 others with EBV+ grafts seroconverted but did not become symptomatic. These two subgroups did not differ in age, rejection rate, antiviral prophylaxis, or level of immunosuppression. In the overall group of 81 children, only the two with malignant lymphoma who were managed with chemotherapy had substantial morbidity. The 10 individuals with PTLD received a regimen combining i.v. ganciclovir and CytoGam, and stopping or reducing the tacrolimus. Four children with associated marked tonsilar growth underwent tonsillectomy. All 19 individuals with EBV disorders resolved their symptoms and signs, and all have maintained good allograft function during a follow-up time of 3.0+/-2.5 years (mean+/-SD) after the development of symptomatic EBV infection, PTLD, or malignancy. We conclude that seronegative recipients of EBV+ grafts are at high risk for developing EBV-related disorders after renal transplantation under tacrolimus-based immunosuppression, although the ultimate clinical outcomes have been remarkably good. These data form the basis for formulating strategies for early identification of children at risk for EBV complications, and for instituting preventive and treatment strategies that permit these children to realize the substantial benefits offered by tacrolimus-based immunosuppression.
Decision Usefulness of Cash Flow Information Format : An Experimental Study

The main purpose of this study is to examine whether the method of presenting financial reports influences the decisions made by their users. Two operating cash flow presentations, namely, direct and indirect, are employed to investigate whether the presentation format of operating cash flow influences lending decisions using financial information about a hypothetical retail company, as a pilot study for an international project. Thirty-eight accounting students (graduates and undergraduates) participated. Following the methodology of Klammer and Reed (1990) and Conover et al. (2011), the findings show that more accurate decisions can be made by the direct method of presentation than by the indirect method of presentation.
Children designers in the museum: applying participatory design for the development of an art education program

In this paper, we describe the application of a participatory design methodology with children, developed within the context of an informal educational institution, specifically the National Gallery of Art in Athens, Greece. A group of 11 year-olds spent part of their summer learning about art conservation in order to design an on-line art education program targeted to children of their age. This paper presents the research, design, and prototype development process, and discusses the lessons-learned, challenges, and future possibilities of this methodology with respect to the design of museum education programs and exhibitions.
Salesperson Goal Orientations and the Selling Performance Relationship: The Critical Role of Mediation and Moderation

Over the last two decades studies have demonstrated the importance of goal orientations in the context of selling and established a body of the main antecedents and outcomes. A closer look at the empirical findings reveals that the relationship between goal orientations and performance remains partly inconsistent as there is mixed evidence of the learning orientation performance relationship partly conflicting with theory. We propose that these findings can be clarified by studying moderation effects related to the nomological network of goal orientations. In testing a research model focused on the interrelations of goal orientations, selling experience, adaptive selling and salesperson selling performance, we confirm the established relationships and show that the learning orientation performance relationship is more complex than earlier studies suggest. The main findings regarding moderation effects indicate that the effectiveness of learning orientation is contingent on selling experience and that learning orientation affects performance also indirectly by helping salespeople adapt their sales styles more effectively. Ignoring these interaction effects will undermine the role of learning orientation in selling performance bearing also concrete implications for sales management.
Impact of DOM composition on bacterial lipids and community structure in estuaries

This study explored the relationship between lipid composition and bacterial commu- nity structure during growth of natural bacterial communities in the Chesapeake and Delaware bays. Experiments examined the effect of the addition of protein, glucose and site-specific >1 kDa ultra- filtered DOM (dissolved organic matter) on bacterial fatty acids and bacterial community structure determined by fluorescence in situ hybridization (FISH). We examined 3 environments over an estuarine gradient comprising a freshwater marsh, the anoxic waters of the central Chesapeake Bay channel, and the Lower Delaware Bay, to encompass a range of bacterial communities and to deter- mine how each community might respond to varying DOM sources in terms of both community structure and lipid signatures. The results demonstrated that fatty acids produced by bacteria depend on carbon source, with consistent trends regardless of physical environment and initial community structure. In contrast to the fatty acid signatures, the FISH results suggested that no single group of bacteria responded consistently to the addition of DOM, either as individual substrates or as complex natural material. The results suggest that while fatty acid synthesis appears strongly associated with dissolved substrates, assignments of specific bacterial groups to fatty acid signatures are not possible at broad phylogenetic levels.
Skills, Education and Productivity in the Service Sector - Firm Level Evidence on the Presence of Externalities

Increased productivity is one of the main drivers of economic growth. Considering the increasing importance of the service sector in many economies studies of productivity in service firms are essential, but still rare. Questions concerning the underlying reasons for productivity differences in service firms are therefore important. Why is the productivity in certain firms higher than in others and what are the possibilities for less-productive firms to increase their productivity levels? This paper aims to examine these issues with a particular focus on the importance of externalities. Externalities are defined as region-specific economic effects influencing firm efficiency. These externalities can be broadly divided in the following categories: i) urbanization economies which relate to diversity and density (Jacobs externalities), ii) localization economies which concern specialization and concentration (MAR externalities), iii) competition (Porter externalities), and iv) labor market externalities. The purpose of the paper is to explain the productivity levels of Swedish service firms using measures of these externalities. However, also firm specific characteristics, including characteristics of the workforce, are included. These are used both as control variables and to capture potential spillover effects that indirectly affect productivity through the employees. The characteristics of the workforce are essential to include since the employees have the potential to affect the way different firms absorb and use possible spillover effects. They are therefore a crucial component to channel externalities to the firm as a whole. This is the case especially for service firms since these are generally very labor intensive. The results of this study should be of interest to policy makers since they have the possibility to make decisions that contribute to more productive regional environments. This is also of interest to company leaders since they have the possibility to decide where to locate and how to structure their firms in order to take advantage of productivity enhancing externalities.
An evaluation of three-dimensional ultrasonography for the measurement of gallbladder volume

OBJECTIVE:Various three-dimensional ultrasonography systems have been developed. We estimated the accuracy of a three-dimensional ultrasonography system for measuring gallbladder volume and compared the results to the sum-of-cylinders method.METHODS:In an in vitro study, 10 balloons of various shapes, sized 5–68 mL were scanned by real-time ultrasonography. In an in vivo study, we evaluated the gallbladder emptying of 14 healthy male volunteers after ingestion of two raw egg yolks. In both studies, volume measurement was performed by the three-dimensional ultrasonography method and the sum-of-cylinders method.RESULTS:With the three-dimensional ultrasonography method, the mean difference between the measured volume and the true volume and the limits of agreement were smaller than those of the sum-of-cylinders method. Gallbladder volumes did not differ significantly with both ultrasound methods.CONCLUSION:The three-dimensional ultrasonography method accurately determined gallbladder volumes.
Loop domain organization of the p53 locus in normal and breast cancer cells correlates with the transcriptional status of the TP53 and the neighboring genes

P53 is a tumor suppressor protein critical for genome integrity. Although its control at the protein level is well known, the transcriptional regulation of the TP53 gene is still unclear. We have analyzed the organization of the TP53 gene domain using DNA arrays in several breast cancer and control cell lines. We have found that in the control breast epithelial cell line, HB2, the TP53 gene is positioned within a relatively small DNA domain, encompassing 50 kb, delimited by two nuclear matrix attachment sites. Interestingly, this domain structure was found to be radically different in the studied breast cancer cell lines, MCF7, T47D, MDA‐MB‐231, and BT474, in which the domain size was increased and TP53 transcription was decreased. We propose a model in which the organization of the TP53 gene domain correlates with the transcriptional status of TP53 and neighboring genes. J. Cell. Biochem. 112: 2072–2081, 2011. © 2011 Wiley‐Liss, Inc.
Title Development and Validation of a New Automatic Algorithm for Quantification of Left Ventricular Volumes and Function in Gated Myocardial Perfusion SPECT using Cardiac Magnetic Resonance as Reference Standard Authors

Citation for published version (APA): Fransson, H. , Hedeer, F. , Arévalo, C. , Carlsson, M. , Engblom, H. , Ubachs, J., . Heiberg, E. (2011). Development and validation of a new automatic algorithm for quantification of left ventricular volumes and function in gated myocardial perfusion SPECT using cardiac magnetic resonance as reference standard. Journal of Nuclear Cardiology, 18(5), 874-885. DOI: 10.1007/s12350-011-9427-3
Differential Attrition Rates and Active Parental Consent

Active parental consent in survey research poses ethical and practical concerns. One common argument against the requirement of active consent procedures is its effect on participation rates. There is additional concern that higher risk groups may be underrepresented in the final sample. Empirical support of differential attrition, however, is lacking. In the current multisite longitudinal study, passive consent procedures were approved for the collection of pretest data. For subsequent years of data collection, active parental consent procedures were required. In this article, we use the pretest data to examine demographic, attitudinal, and behavioral differences between those students for whom active consent was provided and those for whom active consent was either denied or for whom no response was received. The results indicate that active consent procedures produce deleterious effects on participation rates and lead to an underrepresentation of at-risk youth in the sample.
Awareness about tuberculosis among nurses working in a tuberculosis hospital and in a general hospital in Delhi, India.

SETTING A tuberculosis institute and a general hospital in Delhi, India. OBJECTIVE To investigate the awareness of nurses about tuberculosis and to evaluate the differences in awareness, if any, between nurses working in tuberculosis and those in a general hospital. DESIGN A pretested questionnaire survey was performed on 213 nurses. RESULTS The present study showed that a substantial number of nurses have inadequate knowledge regarding causative factors, the importance of sputum examination, correct doses of routinely used short-course chemotherapy drugs, the minimum duration of short-course chemotherapy, instructions at discharge, and health education for patients and family members. If responding correctly to 75% of the questions asked is taken as the criterion for satisfactory awareness, only 40.2% of tuberculosis nurses and 10.7% of general hospital nurses had a satisfactory level of awareness. There was no effect of increasing age or years of experience on the level of awareness. CONCLUSIONS There is a general lack of knowledge regarding various aspects of tuberculosis among nurses. Active interventions are required to improve awareness for a better implementation of the revised national tuberculosis control programme in India.
Analysis of three amphibian populations with quarter–century long time–series

Amphibians are in decline in many parts of the world. Long time–series of amphibian populations are necessary to distinguish declines from the often strong fluctuations observed in natural populations. Time series may also help to understand the causes of these declines. We analysed 23 to 28–year long time series of the frogRana temporaria. Only one of the three studied populations showed a negative trend which was probably caused by the introduction of fish. Two populations appeared to be density regulated. Rainfall had no obvious effect on the population fluctuations. Whereas long–term studies of amphibian populations are valuable to document population declines, most are too short to reveal those factors that govern population dynamics or cause amphibian populations to decline.
Music video shot segmentation using independent component analysis and keyframe extraction based on image complexity

In recent years, Music video data is increasing at an astonishing speed. Shot segmentation and keyframe extraction constitute a fundamental unit in organizing, indexing, retrieving video content. In this paper a unified framework is proposed to detect the shot boundaries and extract the keyframe of a shot. Music video is first segmented to shots by illumination-invariant chromaticity histogram in independent component (IC) analysis feature space . Then we presents a new metric, image complexity, to extract keyframe in a shot which is computed by ICs. Experimental results show the framework is effective and has a good performance.
Long-term results after resection arthroplasty in Kienböck’s disease

Bland JD, Rudolfer SM. Clinical surveillance of carpal tunnel syndrome in two areas of the United Kingdom, 1991– 2001. J Neurol Neurosurg Psychiatry. 2003, 74: 1674–9. Latinovic R, Gulliford MC, Hughes RA. Incidence of common compressive neuropathies in primary care. J Neurol Neurosurg Psychiatry. 2006, 77: 263–5. Ono S, Clapham PJ, Chung KC. Optimal management of carpal tunnel syndrome. Int J Gen Med. 2010, 3: 255–61. Papanicolaou GD, McCabe SJ, Firrell J. The prevalence and characteristics of nerve compression symptoms in the general population. J Hand Surg Am. 2001, 26: 460–6.
Conceptual Model for the Use of ICT Systems to Facilitate Manufacturing SME Servitization

This paper presents a conceptual framework on which to base further empirical research into Manufacturing SMEs’ (MSMEs) deployment of ICT systems to achieve successful servitized manufacturing strategies. The development of manufacturing servitization theory and research surrounding SME organisational characteristics are synthesised with insights from a single case company to propose means for MSMEs to overcome servitization transformation challenges recognised in the literature and in practice. This work is founded on a review of the literature and experience in a single case MSME, so whilst presenting a valuable platform, requires further research to be validated. This research contributes to a developing facet of an emerging topic in Operations Management by providing a model which considers manufacturing servitization through the lens of ICT systems, as well as in the underdeveloped research context of MSMEs.
Do special economic areas matter in attracting FDI? Evidence from Poland, Hungary and Czech Republic

Among the instruments aimed to attract internationally mobile investors, “special economic areas” can be considered as well-defined zones where usually offering low rates of taxation, and infrastructures and services accessible on preferential basis. Are those instruments effective in attracting FDI? The first empirical evidence based on Poland, Hungary and Czech Republic suggests a positive answer. However, according to a survey on research and development intensity in special economic areas in our sample countries, it is not possible to confirm clearly that scientific and technology parks were capable in attracting high-tech FDIs, even though due to global competition, international agreements and EU membership, fiscal incentives are nowadays not enough while technology and an “innovation-friendly” environment are emerging as competitive advantages.
The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline

In the past years, the possible involvement of inflammation in the pathogenesis of dementia has been the subject of several investigations. However there are restricted data about the profile of the inflammatory and soluble proteins in well evaluated Alzheimer’s disease (AD), vascular dementia (VD), mild cognitive impairment (MCI) and healthy controls. There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. We measured levels of IL-1β, IL-2, IL-6, IL-18, TNF-α, β-Amlyloid 1–40 and α1-antichymotrypsin levels in plasma in groups of total 82 subjects with AD, MCI, VD and controls using enzyme-linked immunosorbent assay (ELISA) method. Our study samples showed high levels of proinflammatory cytokine levels (especially IL-18) in all patient groups but only high levels of α1-antichymotrypsine in VD patients compared to controls. There is no significant correlation between the laboratory and clinical variables except for a link between IL-1β and NPI scores of AD. In conclusion, this study yielded evidence of some shared mechanisms underlying AD and VD and thus motivates further studies of inflammatory markers in various types of dementia and MCI.
Increase in Numerical Magnitude from Left-to-Right Shortens Perceived Time

The present study examined the effect of viewing spatially ordered numbers on time perception. Five single digits were presented as the test stimuli. The digits were chosen from 1 to 9 and presented in a horizontal line. We tested the arrangement of the digits in three conditions, where numerical magnitude of the digits increased from left to right (Small-Large condition), decreased from left to right (Large-Small condition), or in a random order (Random condition). Observers were asked to reproduce the presentation duration of the stimuli by pressing the spacebar for as long as the stimulus had been presented. The results showed that the reproduced time was shorter in the Small-Large condition than the other two conditions. The effect of numerical order on time perception is discussed from the perspective of the mental representation of numbers and fluency of cognitive processing.
Asp3 mediates multiple protein–protein interactions within the accessory Sec system of Streptococcus gordonii

Bacterial binding to human platelets is an important step in the pathogenesis of infective endocarditis. Streptococcus gordonii can mediate its platelet attachment through a cell wall glycoprotein termed GspB (‘gordonii surface protein B’). GspB export is mediated by a seven‐component accessory Sec system, containing two homologues of the general secretory pathway (SecA2 and SecY2) and five accessory Sec proteins (Asps1–5). Here we show that the Asps are required for optimal export of GspB independent of the glycosylation process. Furthermore, yeast two‐hybrid screening of the accessory Sec system revealed interactions occurring between Asp3 and the other components of the system. Asp3 was shown to bind SecA2, Asp1, Asp2 and itself. Mutagenesis of Asp3 identified N‐ and C‐terminal regions that are essential for GspB transport, and conserved residues within the C‐terminal domain mediated Asp3 binding to other accessory Sec components. The loss of binding by Asp3 also resulted in an impaired ability of S. gordonii to secrete GspB. These studies indicate that Asp3 is a central element mediating multiple interactions among accessory Sec components that are essential for GspB transport to the cell surface.
The Meaning of Employer Branding Traditional and Web 2.0 Concepts

analyzing the diverse literatures in Marketing and Human Resource Management, this paper endeavors to define and compare traditional and web 2.0 employer branding concepts. Besides defining these concepts also employing interviews with recruiters and personnel marketers, this study investigates which of the identified employer branding concepts are applied by the 109 of the best Dutch employers. To accomplish this goal, the company websites, company blogs and other digital media data were analyzed. A survey conducted with personnel marketers of these companies provides complementary insights for conceptualizing employer branding concepts.