Miracle-dz/UniFAR-FTUs huggingface dataset:
Topical review: spins and mechanics in diamond

There has been rapidly growing interest in hybrid quantum devices involving a solid-state spin and a macroscopic mechanical oscillator. Such hybrid devices create exciting opportunities to mediate interactions between disparate quantum bits (qubits) and to explore the quantum regime of macroscopic mechanical objects. In particular, a system consisting of the nitrogen-vacancy defect center (NV center) in diamond coupled to a high-quality-factor mechanical oscillator is an appealing candidate for such a hybrid quantum device, as it utilizes the highly coherent and versatile spin properties of the defect center. In this paper, we will review recent experimental progress on diamond-based hybrid quantum devices in which the spin and orbital dynamics of single defects are driven by the motion of a mechanical oscillator. In addition, we discuss prospective applications for this device, including long-range, phonon-mediated spin–spin interactions, and phonon cooling in the quantum regime. We conclude the review by evaluating the experimental limitations of current devices and identifying alternative device architectures that may reach the strong coupling regime.
Ruptured Pyogenic Liver Abscess with Pneumoperitoneum 19 Years After Pancreatoduodenectomy

Patient: Male, 42 Final Diagnosis: Ruptured liver abscess • local peritonitis Symptoms: Severe abdominal pain • fever with a body temperature of 39°C • jaundice and severe weakness Medication: — Clinical Procedure: Laparotomy, drainage of the liver abscess Specialty: Surgery Objective: Rare co-existence of disease or pathology Background: Rupture of a pyogenic liver abscess is rare but serious complication. In patients after pancreatoduodenectomy, there are some conditions causing the development of liver abscesses (e.g., chronic reflux-cholangitis, efferent jejunal loop stasis, stenosis of the biliary anastomosis, and pancreatogenic diabetes). However, the number of published cases of liver abscess after pancreatoduodenectomy is small. Case Report: A 42-year-old male was admitted with severe abdominal pain, fever, and jaundice. Nineteen years previously, he had undergone pancreatoduodenectomy and cholecystectomy for chronic pancreatitis with obstructive jaundice. Two years later, diabetes mellitus was diagnosed, with subsequent insulin treatment. At admission, symptoms of peritonitis were present. Plain abdominal radiography showed free gas under the right hemidiaphragm and heterogeneous liver shade with small gas-fluid levels. The rupture of a liver abscess was suspected. Laparotomy with adhesiolysis, debridement of the liver abscess cavity, and abdominal drainage were performed. The postoperative period was complicated by sepsis, right lower lobe pneumonia, and two-sided pleural effusions, on the background of insulin-dependent diabetes and malnutrition. The patient was discharged on the 40th day and the subdiaphragmatic drains were removed on the 114th day. Sixteen months after surgery, the patient’s condition was satisfactory. Magnetic resonance imaging and echography showed the absence of biliary hypertension. The liver tissue had healed completely. Conclusions: A unique case of ruptured liver abscess after pancreatoduodenectomy is presented. To the best of our knowledge, this is the first published case with such a long time interval (19 years) between pancreatoduodenectomy and the formation of a pyogenic liver abscess.
Ecological Aspects of the Vector-Borne Bacterial Disease, Citrus Greening (Huanglongbing): Dispersal and Host Use by Asian Citrus Psyllid, Diaphorina Citri Kuwayama

Determining the influence of abiotic and biotic factors on pest dispersal behavior is a critical component of integrated pest management. The behavioral and physiological traits of movement of the Asian Citrus Psyllid (ACP), Diaphorina citri Kuwayama, has received significant attention. Field and laboratory experiments have explored the physiological capabilities of ACP dispersal, as well as, the abiotic and biotic drivers that initiate movement behavior. Abiotic factors such as temperature, barometric pressure, humidity, landscape, and orchard architecture, as well as, biotic factors including mating status, pathogen infection, and morphotype have been investigated in great detail. The current review focuses on dispersal of ACP with the goal of synthesizing current knowledge to suggest management tactics. Overall, vision serves as the primary modality for host finding in ACP. Current data suggest that ACP populations increase more within uniform landscapes of seedling trees, as compared to mature orchards with randomly interspersed young seedlings. The data also suggest that establishment and conservation of visual and physical barriers might be beneficial to protect orchards from ACP. Management of ACP must take into account large-area cooperation, orchard border surveillance and treatment, removal of non-crop habitat, and an understanding that immigration can occur from distances of several kilometers.
Age-related changes and effects of regular low-intensity exercise on gait, balance, and oxidative biomarkers in the spinal cord of Wistar rats

The present study aimed to analyze age-related changes to motor coordination, balance, spinal cord oxidative biomarkers in 3-, 6-, 18-, 24-, and 30-month-old rats. The effects of low-intensity exercise on these parameters were also analyzed in 6-, 18-, and 24-month-old rats. Body weight, blood glucose, total cholesterol, and high-density lipoprotein (HDL) cholesterol were assessed for all rats. The soleus muscle weight/body weight ratio was used to estimate skeletal muscle mass loss. Body weight increased until 24 months; only 30-month-old rats exhibited decreased blood glucose and increased total cholesterol and HDL cholesterol. The soleus muscle weight/body weight ratio increased until 18 months, followed by a small decrease in old rats. Exercise did not change any of these parameters. Stride length and step length increased from adult to middle age, but decreased at old age. Stride width increased while the sciatic functional index decreased in old rats. Performance in the balance beam test declined with age. While gait did not change, balance improved after exercise. Aging increased superoxide anion generation, hydrogen peroxide levels, total antioxidant capacity, and superoxide dismutase activity while total thiol decreased and lipid hydroperoxides did not change. Exercise did not significantly change this scenario. Thus, aging increased oxidative stress in the spinal cord, which may be associated with age-induced changes in gait and balance. Regular low-intensity exercise is a good alternative for improving age-induced changes in balance, while beneficial effects on gait and spinal cord oxidative biomarkers cannot be ruled out because of the small number of rats investigated (n=5 or 6/group).
A Meta-Analysis of Job Insecurity and Employee Performance: Testing Temporal Aspects, Rating Source, Welfare Regime, and Union Density as Moderators

Previous research has shown that job insecurity is linked to a range of performance outcomes, but the number of studies exploring this relationship is still limited and the results are somewhat mixed. The first aim of this study was to meta-analytically investigate how job insecurity is related to task performance, contextual performance, counterproductive work behavior, creativity, and safety compliance. The second aim was to test two method-related factors (cross-sectional vs. longitudinal associations and self- vs. supervisor-ratings of performance) and two macro-level indicators of social protection (social welfare regime and union density) as moderators of these associations. The results show that job insecurity was generally associated with impaired employee performance. These findings were generally similar both cross-sectionally and longitudinally and irrespective of rater. Overall, the associations between job insecurity and negative performance outcomes were weaker in welfare regimes characterized by strong social protection, whereas the results concerning union density produced mixed results. A majority of the findings confirmed the negative associations between job insecurity and types of employee performance, but future research is needed to elaborate on the effects of temporal aspects, differences between ratings sources, and further indicators of social protection in different cultural settings in the context of job insecurity.
Influence of Pain and Analgesia on Cancer Research Studies.

Mice and rats are valuable and commonly used as models for the study of cancer. The models and methods of experimentation have the potential to cause pain to some degree, and all charged with ensuring animal welfare must determine how to manage it. A commonly posed question, especially from investigators and IACUC, is whether the provision of analgesic agents will render the model invalid. Left untreated, pain is a stressor and has negative consequences, most notably immune system perturbations. In addition, analgesic agents in the opioid and NSAID drug classes exhibit immunomodulatory activity and influence processes such as cell proliferation, apoptosis, and angiogenesis that are important in cancer formation. Therefore,both pain and the agents used to alleviate it have the potential to act as confounding factors in a study. This review article presents data from both human medicine and work with animal models in an attempt to help inform discussions about the withholding of analgesic agents from animals used in cancer studies.
Alteration of coupling between brain and heart induced by sedation with propofol and midazolam

For a comprehensive understanding of the nervous system, several previous studies have examined the network connections between the brain and the heart in diverse conditions. In this study, we identified coupling between the brain and the heart along the continuum of sedation levels, but not in discrete sedation levels (e. g., wakefulness, conscious sedation, and deep sedation). To identify coupling between the brain and the heart during sedation, we induced several depths of sedation using patient-controlled sedation with propofol and midazolam. We performed electroencephalogram (EEG) spectral analysis and extracted the instantaneous heart rate (HR) from the electrocardiogram (ECG). EEG spectral power dynamics and mean HR were compared along the continuum of sedation levels. We found that EEG sigma power was the parameter most sensitive to changes in the sedation level and was correlated with the mean HR under the effect of sedative agents. Moreover, we calculated the Granger causality (GC) value to quantify brain-heart coupling at each sedation level. Additionally, the GC analysis revealed noticeably different strengths and directions of causality among different sedation levels. In all the sedation levels, GC values from the brain to the heart (GCb→h) were higher than GC values from the heart to the brain (GCh→b). Moreover, the mean GCb→h increased as the sedation became deeper, resulting in higher GCb→h values in deep sedation (1.97 ± 0.18 in propofol, 2.02 ± 0.15 in midazolam) than in pre-sedation (1.71 ± 0.13 in propofol, 1.75 ± 0.11 in midazolam; p < 0.001). These results show that coupling between brain and heart activities becomes stronger as sedation becomes deeper, and that this coupling is more attributable to the brain-heart direction than to the heart-brain direction. These findings provide a better understanding of the relationship between the brain and the heart under specific conditions, namely, different sedation states.
A GLOBAL CORRECTION TO PPMXL PROPER MOTIONS

In this paper we note that extragalactic sources seem to have non-zero proper motions in the PPMXL proper motion catalog. We collect a large, all sky sample of extragalactic objects and fit their reported PPMXL proper motions to an ensemble of spherical harmonics in magnitude shells. A magnitude-dependent proper motion correction is thus constructed. This correction is applied to a set of fundamental radio sources, quasars, and is compared to similar corrections to assess its utility. We publish, along with this paper, a code that can be used to correct proper motions in the PPMXL catalog over the full sky; this code requires Two Micron All Sky Survey photometry.
肺癌组织中DNA聚合酶β基因突变的研究

背景与目的 DNA聚合酶β是参与DNA损伤修复的关键酶之一，国外有学者认为其编码基因Polb在30%的肿瘤中存在遗传突变，但受到所用标本量的限制，这一结论是否准确尚无定论。 本研究基于基因测序技术，通过对69例肺癌患者组织标本的基因筛查，旨在明确DNA聚合酶β的基因突变在中国汉族人群肺癌患者中的发生频率。 方法 利用盐析法提取69例肺癌患者的癌及癌旁组织基因组DNA，并用于扩增Polb基因全部14个外显子区及启动子区。 通过与NCBI数据库中野生型基因序列进行比对，系统分析肺癌组织中的Polb基因突变及其频率。 结果 相对于野生型，本研究共发现5种突变类型，其中3种（-196G > T, -188_-187insCGCCC, -168C > A）位于启动子区，2种（587C > G, 612A > T）位于外显子区，突变类型-188_-187insCGCCC和587C > G尚未见文献报道，后者可引起第196位氨基酸由苏氨酸突变为丝氨酸。 另一方面，癌和癌旁组中均可检测到所有5种突变类型，提示这些突变并非肺癌组织所特有。 结论 肺癌组织中未发现特异性表达的Polb基因突变位点，Polb基因突变可能不是中国汉族肺癌患者的肿瘤标志物。
Potential of isoquercitrin as antisickling agent: a multi-spectroscopic, thermophoresis and molecular modeling approach

Abstract Sickle cell disease is an inherited disease caused by point mutation in hemoglobin (β-globin gene). Under oxygen saturation, sickle hemoglobin form polymers, leading to rigid erythrocytes. The transition of the blood vessels is altered and initiated by the adhesion of erythrocytes, neutrophils and endothelial cells. Sickle Hemoglobin (HbS) polymerization is a major cause in red blood cells (RBC), promoting sickling and destruction of RBCs. Isoquercitrin, a medicinal bioactive compound found in various medicinal plants, has multiple health benefits. The present study examines the potential of isoquercitrin as an anti-sickle agent, showing a significant decrease in the rate of polymerization as well as sickling of RBCs. Isoquercitrin-induced graded alteration in absorbance and fluorescence of HbS, confirmed their interaction. A negative value of ΔG° strongly suggests that it is a spontaneous exothermic reaction induced by entropy. Negative ΔH° and positive ΔS° predicted that hydrogen and hydrophobic binding forces interfered with a hydrophobic microenvironment of β6Val leading to polymerization inhibition of HbS. HbS-Isoquercitrin complex exhibits helical structural changes leading to destabilization of the HbS polymer as confirmed by CD spectroscopy. MST and DSC results indicate greater changes in thermophoretic mobility and thermal stability of sickle hemoglobin in the presence of isoquercitrin, respectively. These findings were also supported by molecular simulation studies using DOCK6 and GROMACS. Hence, we can conclude that isoquercitrin interacts with HbS through hydrogen bonding, which leads to polymerization inhibition. Consequently, isoquercitrin could potentially be used as a medication for the treatment of sickle cell disease. Communicated by Ramaswamy H. Sarma
Trypsin Pre‐Treatment Combined With Growth Factor Functionalized Self‐Assembling Peptide Hydrogel Improves Cartilage Repair in Rabbit Model

The objective of this study was to improve cartilage repair and integration using self‐assembling KLD hydrogel functionalized with platelet‐derived growth factor‐BB and heparin‐binding insulin‐like growth factor‐1 with associated enzymatic trypsin pre‐treatment of the native cartilage. Bilateral osteochondral defects were created at the central portion of the femoral trochlear groove of 48 skeletally mature, white New Zealand rabbits. One limb received a randomly assigned treatment and the contralateral limb served as the control. Treated defects were exposed to trypsin for 2 min and filled with self‐assembling KLD hydrogel only, or associated to growth factors. All control limbs received KLD hydrogel alone or received only trypsin but not hydrogel. Ninety days post‐defect creation, the rabbits were euthanized and magnetic resonance imaging, radiography, macroscopic evaluation, histology, and immunohistochemistry of the joint and repaired tissue were performed. Mixed model analyses of variance were utilized to assess the outcome parameters and individual comparisons were performed using Least Square Means procedure and differences with p‐value < 0.05 were considered significant. Trypsin enzymatic pre‐treatment improved cellular morphology, cluster formation and subchondral bone reconstitution. Platelet‐derived growth factor‐BB improved subchondral bone healing and basal integration. Heparin‐binding insulin‐like growth factor‐1 associated with platelet‐derived growth factor improved tissue and cell morphology. The authors conclude that self‐assembling KLD hydrogel functionalized with platelet‐derived growth factor and heparin‐binding insulin‐like growth factor‐1 with associated enzymatic pre‐treatment of the native cartilage with trypsin resulted in an improvement on the cartilage repair process. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2307–2315, 2019
Cardiovascular risk assessment using the lipid accumulation product index among primary healthcare users: a cross-sectional study

ABSTRACT BACKGROUND: The lipid accumulation product (LAP) index is an abdominal adiposity marker. OBJECTIVE: The aim of this study was to describe the cardiovascular risk of primary healthcare users through the LAP index and correlate it with anthropometric and biochemical indicators. DESIGN AND SETTING: Cross-sectional study in primary care units in a city in northeastern Brazil. METHODS: The subjects responded to a structured questionnaire that contained questions about their sociodemographic condition, and then underwent an anthropometric nutritional assessment. The LAP index values were expressed as three degrees of cardiovascular risk intensity: high risk (above the 75th percentile), moderate risk (between the 25th and 75th percentiles) and low risk (below the 25th percentile). RESULTS: The median LAP index was 52.5 cm.mmol/l (range: 28.2-86.6), and there was no statistically significant difference between the sexes: 57.7 cm.mmol/l (24.5-91.1) and 49.5 cm.mmol/l (29.8-85.2) for females and males, respectively (P = 0.576). Among all the subjects, 67.2% were overweight and there was a statistically significant difference in mean LAP index between those who were and those who were not overweight. Statistically significant differences in anthropometric and biochemical markers for cardiovascular risk were observed among individuals who had higher LAP index values. There were significant correlations between the LAP index and all of the biochemical variables. CONCLUSIONS: These significant correlations between the LAP index and the traditional biochemical risk markers may be useful within conventional clinical practice, for cardiovascular risk screening in primary healthcare.
Minimal Auxin Sensing Levels In Vegetative Moss Stem Cells Revealed By A Ratiometric Reporter.

•Efforts to reveal ancestral functions of auxin, a key regulator of plant growth and development, and its importance for evolution has been hampered by a fragmented picture of auxin response domains in early diverging land plants. We report the mapping of auxin sensing and responses during vegetative moss development using novel reporters. •We established a moss-specific ratiometric reporter (PpR2D2) for Auxin Response Element- and AUXIN RESPONSE FACTOR-independent auxin sensing in Physcomitrella patens, and its readout during vegetative development was compared to new promoter-based GmGH3::GFPGUS and DR5revV2::GFPGUS auxin response reporters. •The ratiometric reporter responds rapidly to auxin in a time-, dose- and TRANSPORT INHIBITOR RESISTANT1/AUXIN F-BOX-dependent manner and marks known, anticipated and novel auxin sensing domains. It reveals proximal auxin sensing maxima in filamentous tissues and sensing minima in all five vegetative gametophytic stem cell types as well as dividing cells. •PpR2D2 readout is compliant with an ancestral function of auxin as a positive regulator of differentiation vs. proliferation in stem cell regions. The PpR2D2 reporter is a sensitive tool for high resolution mapping of auxin sensing, which can increase our knowledge of auxin function in early diverging land plants substantially, thereby advancing our understanding of its importance for plant evolution. This article is protected by copyright. All rights reserved.
Stellar ages, masses, and radii from asteroseismic modeling are robust to systematic errors in spectroscopy

Context. The search for twins of the Sun and Earth relies on accurate characterization of stellar and the exoplanetary parameters age, mass, and radius. In the modern era of asteroseismology, parameters of solar-like stars are derived by fitting theoretical models to observational data, which include measurements of their oscillation frequencies, metallicity [Fe/H], and effective temperature Teff. Furthermore, combining this information with transit data yields the corresponding parameters for their associated exoplanets. Aims. While values of [Fe/H] and Teff are commonly stated to a precision of ∼0.1 dex and ∼100 K, the impact of systematic errors in their measurement has not been studied in practice within the context of the parameters derived from them. Here we seek to quantify this. Methods. We used the Stellar Parameters in an Instant (SPI) pipeline to estimate the parameters of nearly 100 stars observed by Kepler and Gaia, many of which are confirmed planet hosts. We adjusted the reported spectroscopic measurements of these stars by introducing faux systematic errors and, separately, artificially increasing the reported uncertainties of the measurements, and quantified the differences in the resulting parameters. Results. We find that a systematic error of 0.1 dex in [Fe/H] translates to differences of only 4%, 2%, and 1% on average in the resulting stellar ages, masses, and radii, which are well within their uncertainties (∼11%, 3.5%, 1.4%) as derived by SPI. We also find that increasing the uncertainty of [Fe/H] measurements by 0.1 dex increases the uncertainties of the ages, masses, and radii by only 0.01 Gyr, 0.02 M⊙, and 0.01 R⊙, which are again well below their reported uncertainties (∼0.5 Gyr, 0.04 M⊙, 0.02 R⊙). The results for Teff at 100 K are similar. Conclusions. Stellar parameters from SPI are unchanged within uncertainties by errors of up to 0.14 dex or 175 K. They are even more robust to errors in Teff than the seismic scaling relations. Consequently, the parameters for their exoplanets are also robust.
Factors associated with the intention to use adult preventive health services in Taiwan.

OBJECTIVE This research aimed to examine the factors associated with the intention to use adult preventive health services in Taiwan. DESIGN AND SAMPLE Using Andersen's behavioral model, we employed a cross-sectional descriptive design to investigate 500 samples from four communities in southern Taiwan. MEASURES We used a self-reported survey to assess participants' intention to use adult preventive health services, and the predisposing, enabling, and need factors influencing their intention. RESULTS Intention to use adult preventive health services was more significantly explained by predisposing and enabling factors than by need factors. In addition, a lack of fixed medical facilities (enabling factor) and Taiwanese origin (predisposing factor) were associated with decreased odds of intention to use adult preventive health services. An educational level of high school or below (predisposing factor), higher amounts of exercise (predisposing factor), and lower barriers to use preventive health services (predisposing factor) were associated with increased odds of intention to use adult preventive health services. CONCLUSION The findings can assist public health nurses in identifying high-risk groups with lower intentions of using adult preventive health services. Additionally, community-based health education program can be developed to increase people's intention to use adult preventive health services.