Miracle-dz/UniFAR-FTUs huggingface dataset:
Organizing For Europe: Whitehall, The British State And European Union

The article examines the adaptation of Whitehall to participation in the European Union. Following an Historical Institutionalist analysis, the article argues that the most critical juncture relating to the machinery for the handling of European business was taken in 1960–1961 well before the third, successful application to join the European Communities. Actual accession brought about an adaptation of the machinery and of the processes developed in negotiation to the wider needs of membership rather than a reform of machinery. Thus the most important alteration in Britain’s overseas relations since the war was easily accommodated within Whitehall’s established approach to handling policy. Developments from the 1970s onwards have largely been accretive and these developments are outlined. However, the article argues that more fundamental challenges deriving from EU membership lie ahead for the structure of the British state.
A Role for the Interferon‐Inducible Protein 10 in Inhibition of Angiogenesis by Interleukin‐12

We have developed a nude mouse model in which tumor regression is reproducibly induced by coinjection with or intratumor inoculation of EBV-immortalized B cells. A wide spectrum of tumor-derived human cell lines can be established as subcutaneous tumors in sublethally irradiated athymic mice. Most of these tumors are induced to regress by human B cells immortalized with EBV. The tumor regression process is characterized by superficial necrosis and scarring that progressively extends itself to involve all or most of the tumor. Microscopically, tumor regression is characterized by tumor tissue necrosis, evidence of vascular damage with intimal thickening and capillary thrombosis, and macrophage, but not lymphocyte or neutrophil, infiltration. Profiles of cytokine expression differed between progressive and regressive Burkitt's tumors in that regressive tumors expressed larger levels of TNF-alpha, IL-6, IFN-gamma, IP-10, Mig, and IL-12 p35, but not other chemokines/cytokines. IP-10 and IL-12 were found to act as potent inhibitors of angiogenesis in vivo. IL-12 is an inducer of IFN-gamma and indirectly of IP-10, an IFN-gamma-inducible protein, raising the possibility that the antiangiogenic effect of IL-12 is mediated by IP-10. Previous studies have demonstrated that IL-12 has potent antitumor activity in vivo. Much of this activity was dependent on the presence of IFN-gamma and of immune T cells. The observation, made in our studies, that IP-10 is an inhibitor of angiogenesis raises the possibility that IP-10 might contribute to the antitumor effects of IL-12 by inhibiting angiogenesis. Inhibition of angiogenesis by IP-10 and IL-12 is T-cell independent, suggesting that IL-12 targets at least two compartments, T cells and capillaries, each capable of mediating antitumor effects.
Flaxseed as a functional food source

Flaxseed is emerging as one of the key sources of phytochemicals in the functional food arena. In addition to being one of the richest sources of α-linolenic acid oil and lignans, flaxseed is an essential source of high-quality protein and soluble fibre and has considerable potential as a source of phenolic compounds. The implications of diets containing flaxseed or its components for human nutrition and disease prevention are analysed in this paper. Results of the first meta-analysis examining the relationship between intake of flaxseed or its components and risk reduction of disease in humans is presented. Some areas of potential opportunities and impact of using flaxseed or its components in the diet are highlighted. Les graines de lins sont une source de produits fonctionnels: outre leur richesse en acide α-linolenique et en lignanes, elles contiennet des proteines vegetales de haute qualite, des fibres solubles et de nombreux compose phenoliques. Les effets d'un regime alimentaire enrichi en graines de lins ou en ses composants est etudie ici, chez l'homme. les etudes epidemiologiques montrent un effet cardioprotecteur et anticarcinogene.
Key Performance Indicators in Intensive Care Medicine. A Retrospective Matched Cohort Study

Expert panel consensus was used to develop evidence-based process indicators that were independent risk factors for the main clinical outcome parameters of length of stay in the intensive care unit (ICU) and mortality. In a retrospective, matched data analysis of patients from five ICUs at a tertiary university hospital, agreed process indicators (sedation monitoring, pain monitoring, mean arterial pressure [MAP] ≥ 60 mmHg, tidal volume [TV] ≤ 6 ml/kg body weight, peak inspiratory pressure [PIP] ≤ 35 cmH2O and blood glucose [BG] ≥ 80 and ≤ 130 mg/dl) were validated using a prospective dataset of 4445 consecutive patients. After matching for age, sex and ICU, 634 patients were analysed. Logistic regression of the 634 patients showed that monitoring analgesia and sedation, MAP ≥ 60 mmHg and BG ≥ 80 mg/dl were relevant for survival. Linear regression of the 634 patients showed that analgesia monitoring, PIP ≤ 35 cmH2O and TV ≤ 6 ml/kg were associated with reduced length of ICU stay. Linear regression on all 4445 patients showed analgesia, sedation monitoring, MAP ≥ 60 mmHg, BG ≥ 80 mg/dl and ≤ 130 mg/dl, PIP ≤ 35 cmH2O and TV ≤ 6 ml/kg were associated with reduced length of ICU stay, indicating that adherence to evidence-based key process indicators may reduce mortality and length of ICU stay.
Enquête Epidémiologique sur la Légionellose et Prévalence de Legionella pneumophila dans Les Eaux Chaudes Sanitaires au Maroc

La legionellose est une maladie respiratoire humaine provoquee par des bacteries du genre Legionella qui se developpent dans les milieux auquatiques naturels ou artificiels. La prevention de la legionellose repose sur une surveillance clinique et environnementale. La presente etude porte sur la mise au point d'une technique d'investigation sur le terrain, qui sera elargie ulterieurement par une etude a grande echelle, permettant d'identifier la prevalence ecologique des Legionella dans les reseaux de production et de distribution de l’eau chaude sanitaire. Pour realiser ce travail, 40 echantillons d'eaux chaudes, preleves a partir de trente quatre hotels et six domiciles au Maroc, ont ete soumis a la recherche et la numeration de Legionella pneumophila. Les resultats obtenus ont montre que Legionella pneumophila a ete detectee dans 32,5% du total des echantillons analyses dont 62% avec une charge superieure a la limite tolerable par la reglementation. L’etude a egalement montre que Legionella pneumophila est presente dans 29% des echantillons preleves dans les hotels. Les serogroupes 2-15 et 1 sont identifies a des frequences respectives de 60 et 40%. Quant aux echantillons preleves dans les domiciles, 50% revelent la presence de Legionella pneumophila serogroupe 1 avec une charge inferieure a la limite tolerable par la reglementation. L’enquete epidemiologique a montre la presence de deux cas confirmes de legionellose. Les resultats de ce travail doivent inciter les autorites a prendre les mesures necessaires pour la surveillance et la prevention de la legionella au Maroc.
A Clinical Comparison of Men and Women on the Eating Disorder Inventory-3 (EDI-3) and the Eating Disorder Assessment for Men (EDAM)

This study focused on the most commonly used eating disorder assessment tool, the Eating Disorder Inventory-3 (EDI-3), and the preliminary Eating Disorder Assessment for Men (EDAM). These assessment tools were examined to investigate predictability in males and the extent they differentiated between men and women. Specific scales of the EDI-3 and total scores for each instrument were assessed using a sample of 108 males and females from residential treatment facilities. Overall, the EDI-3 scales were shown to be significantly different between genders on a MANOVA, with men scoring significantly lower in body dissatisfaction, drive for thinness, and bulimia. Both instruments showed the ability to predict eating disorders when using a logistical regression analysis. Results support the hypothesis that eating disorders are significantly different in men and women, providing evidence that there is a need to develop a valid and reliable eating disorder assessment tool specifically for men.
The Impact of Corporate Governance on Risk Taking in European Insurance Industry

Authors : Francesco Venuti, Simona Alfiero Abstract : The aim of this paper is to develop an empirical research on the nature and consequences of corporate governance on Eurozone Insurance Industry risk taking attitude. More particularly, we analyzed the effect of public ownership on risk taking with respect to privately held Insurance Companies. We also analyzed the effects on risk taking attitude of different degrees of ownership concentration, directors compensation, and the dimension/diversity of the Board of Directors. Our results provide quite strong evidence that, coherently with the Agency Theory, publicly traded insurance companies with more concentrated ownership are less risky than the corresponding privately held.
Maternal outcomes of a randomized controlled trial of a community-based support program for families of children with chronic illnesses.

BACKGROUND Parents of children with chronic illnesses are at high risk for secondary mental health problems, such as anxiety and depression. OBJECTIVE To evaluate maternal outcomes of a support intervention for families of children with selected chronic illnesses. DESIGN A randomized controlled clinical trial design with repeated measures 1 year apart. SETTING A community-based family support intervention linked to subspecialty and general pediatric clinics and practices in a metropolitan area. PARTICIPANTS A population-based sample of 193 mothers of children aged 7 to 11 years; the children were diagnosed as having diabetes, sickle cell anemia, cystic fibrosis, or moderate to severe asthma. About 15% of the persons contacted refused to participate in the research, and 14% of the families were lost to follow-up. INTERVENTION The 15-month intervention, the Family-to-Family Network, was designed to enhance mothers' mental health by linking mothers of school-aged children with selected chronic illnesses with mothers of older children with the same condition. The program included telephone contacts, face-to-face visits, and special family events. MAIN OUTCOME MEASURES Beck Depression Inventory score and the Psychiatric Symptom Index. RESULTS Maternal anxiety scores for participants in the experimental group decreased during the intervention period for all diagnostic groups and for the total group; scores for the control group increased (F = 5.07, P =.03). In multiple regression analyses, the intervention group was a significant predictor of posttest anxiety scores (P =.03). Effects were greater for mothers with high baseline anxiety (P<.001) and for those who were themselves in poor health (P<.01). CONCLUSIONS A family support intervention can have beneficial effects on the mental health status of mothers of children with chronic illnesses. This type of intervention can be implemented in diverse pediatric settings.
Characteristics of Vogt-Koyanagi-Harada Disease in a French Cohort: Ethnicity, Systemic Manifestations, and HLA Genotype Data

Purpose: To assess in patients followed in a French referral center the clinical spectrum of Vogt-Koyanagi-Harada (VKH) disease and the HLA-DRB1*04 genotype. Methods: Patients previously diagnosed as having VKH disease were re-evaluated in a cross-sectional study using the VKH Committee's revised criteria. High-resolution HLA-DRB1 genotyping was performed. Results: Eleven white patients satisfied ophthalmologic diagnostic criteria. All originated from Mediterranean countries. Nine and 3 patients had neurologic and/or cutaneous abnormalities, respectively. Among DRB1*04-positive patients, the HLA-DRB1*0405 subtype was 71%. Conclusion: These VKH patients predominantly had an incomplete form. The HLA-DRB1*0405 subtype allele was enriched in a group of Mediterranean stock.
Proton Pump Inhibitors Reduce Mycophenolate Exposure in Heart Transplant Recipients—A Prospective Case‐Controlled Study

This prospective study investigates the impact of proton pump inhibitors (PPI) on mycophenolic acid (MPA) pharmacokinetics in heart transplant recipients receiving mycophenolate mofetil (MMF) and tacrolimus. MPA plasma concentrations at baseline (C0 h), 30 min (C0.5 h), 1(C1 h) and 2 h (C2 h) were obtained by high‐performance liquid chromatography (HPLC) in 22 patients treated with pantoprazole 40 mg and MMF 2000 mg. Measurements were repeated 1 month after pantoprazole withdrawal. A four‐point limited‐sampling strategy was applied to calculate the MPA area under the curve (MPA‐AUC). Predose MPA concentrations with PPI were 2.6 ± 1.6 mg/L versus 3.4 ± 2.7 mg/L without PPI (p = ns). Postdose MPA concentrations were lower with PPI at C0.5 h (8.3 ± 5.7 mg/L vs. 18.3 ± 11.3 mg/L, p = 0.001) and C1 h (10.0 ± 5.6 mg/L vs. 15.8 ± 8.4 mg/L, p = 0.004), without significant differences at C2 h (8.3 ± 6.5 mg/L vs. 7.6 ± 3.9 mg/L). The MPA‐AUC was significantly lower with PPI medication (51.2 ± 26.6 mg × h/L vs. 68.7 ± 30.3 mg × h/L; p = 0.003). The maximum concentration of MPA (MPA‐Cmax) was lower (12.2 ± 7.5 mg/L vs. 20.6 ± 9.3 mg/L; p = 0.001) and the time to reach MPA‐Cmax (tmax) was longer with PPI (60.0 ± 27.8 min vs. 46.4 ± 22.2 min; p = 0.05). This is the first study to document an important drug interaction between a widely used immunosuppressive agent and a class of drugs frequently used in transplant patients. This interaction results in a decreased MMF drug exposure which may lead to patients having a higher risk for acute rejection and transplant vasculopathy.
Length Of First Remission and Karyotype: Important Prognostic Factors For Treatment Of Relapsed Acute Myeloid Leukaemia

The length of first remission and karyotype are important prognostic factors for the outcome of salvage chemotherapy and bone marrow transplantation for relapsed acute myeloid leukaemia. These prognostic factors are closely interrelated and patients with favourable karyotypes generally have longer first remissions whereas the converse is true for unfavourable karyotypes. On multivariate analysis, length of first remission had a stronger effect on outcome than karyotype, so that even patients with favourable karyotype were highly likely to relapse again if first remission was shorter than 12 months (Webb et al, 1999). The prognosis for patients with unfavourable karyotype is uniformly poor, irrespective of length of first remission. Finally, it is not clear whether outcome is superior for patients who relapse after a first remission of 6±12 months compared with a first remission of under 6 months. In children who relapsed after initial therapy in the Medical Research Council AML 10 trial, the survival at 12 months was 15% for both groups. Our current practice is to treat children in relapse with further intensive chemotherapy and bone marrow transplantation in second remission, if they have not been previously transplanted. However, there is an obvious need to develop new strategies for the treatment of relapsed disease. Accordingly, given the very poor survival rates for patients with first remissions under 12 months, and at all times for those with poor risk cytogenetics, enrolment in phase I or II studies is a valid option.
Calpains as potential anti-cancer targets

Introduction: The intracellular signaling cysteine proteases, calpains (specifically the ubiquitous calpains 1 and 2), are involved in numerous physiological and pathological phenomena. Several works have highlighted the implication of calpains in processes crucial for cancer development and progression. For these reasons, calpains are considered by several authors as potential anti-cancer targets. Areas covered: How calpains are implicated in cancer formation and development, how these enzymes are deregulated in cancer cells and how these proteases could be targeted by anti-cancer drugs. Studies published in the last 10 years are focused on. Expert opinion: Targeting calpain activity with specific inhibitors could be a novel approach to limiting development of primary tumors and formation of metastases, by inhibiting tumor cell migration and invasion, which allows dissemination as well as tumor neovascularization, which in turn allows expansion. However, such drugs could interfere with anti-cancer treatments, as ubiquitous calpains play crucial roles in chemotherapy-induced apoptosis. For these reasons, drugs targeting calpains would have to be used selectively to avoid interference with other treatments and physiological processes. Further studies will be required concerning the other members of the calpain family and their potential implication in cancer development before considering treatments targeting their activity.
Impaired Frontal-Basal Ganglia Connectivity in Male Adolescents with Conduct Disorder

Alack of inhibition control has been found in subjects with conduct disorder (CD), but the underlying neuropathophysiology remains poorly understood. The current study investigated the different mechanism of inhibition control in adolescent-onset CD males (n = 29) and well-matched healthy controls (HCs) (n = 40) when performing a GoStop task by functional magnetic resonance images. Effective connectivity (EC) within the inhibition control network was analyzed using a stochastic dynamic causality model. We found that EC within the inhibition control network was significantly different in the CD group when compared to the HCs. Exploratory relationship analysis revealed significant negative associations between EC between the IFG and striatum and behavioral scale scores in the CD group. These results suggest for the first time that the failure of inhibition control in subjects with CD might be associated with aberrant connectivity of the frontal–basal ganglia pathways, especially between the IFG and striatum.
Serum CYR61 Is Associated with Disease Activity in Graves’ Orbitopathy

ABSTRACT Purpose: To investigate the clinical implications of cysteine-rich angiogenic inducer 61 (CYR61) in Graves’ orbitopathy (GO). Methods: Sera from 52 GO patients, 23 Graves’ disease (GD) patients, and 20 healthy controls, and orbital fat tissue samples from 12 of 52 GO patients and 8 control subjects were included for analysis. Concentrations of CYR61 were measured from sera with an enzyme-linked immunosorbent assay, and CYR61 mRNA expression levels were evaluated from orbital fat tissue with polymerase chain reaction. Results: Serum CYR61 levels were higher in GO patients than in controls (p = 0.001). Patients with active GO showed higher CYR61 levels than those with inactive GO (p < 0.001) or GD (p = 0.004). Expression of CYR61 mRNA was 7.4-fold higher in patients with GO than in healthy controls (p < 0.001). Conclusions: CYR61 could be an adjuvant biomarker associated with the inflammatory activity of GO.
Estilos de aprendizagem em universitarios

Estilos de aprendizagem relacionam-se a maneira pela qual as pessoas interagem com as condicoes de aprendizagem, abrangendo aspectos cognitivos, afetivos, riscos e ambientais que podem favorecer o processamento de informacoes. Esta pesquisa teve como principais objetivos: 1) adaptar e validar o instrumento "Inventario de Estilo de Aprendizagem" de Kolb (1993) para a populacao-alvo de estudantes universitarios brasileiros; 2) verificar se ha predominância de algum estilo de aprendizagem preferencial na aprendizagem, por area de conhecimento; 3) identificar a relacao entre os estilos de aprendizagem e as variaveis genero, idade, semestres agrupados, regiao do Brasil e tipo de instituigao. Os dados foram coletados utilizando-se o Inventario de Estilo de Aprendizagem de Kolb (1993) e os infcrmantes constituiram-se de 2.552 estudantes universitarios de varios estados das cinco regioes do Brasil, contemplando cursos das oito areas do conhecimento. A validacao de definicao do instrumento foi realizada a partir da concordância elevada de 30 juizes/psicologos quanto a classificacao dos estilos de aprendizagem. Na analise estatistica dos dados, as diferencas significativas indicam que ha predominio do estilo de aprendizagem assimilador em todas as areas do conhecimento, referindo-se a pessoas que aprendem basicamente por observacao reflexiva e conceituacao abstracta. Quanto a relacao entre as variaveis observadas, verificou-se que os estilos de aprendizagem apresentaram diferencas, estatisticamente significantes, entre as faixas etarias, o agrupamento de semestres, a regiao e as areas do conhecimento e nao apresentaram diferencas relacionadas ao genero e ao tipo de instituicao. Pode-se concluir que o estilo assimilador, predominante nos universitarios pesquisados, mantem-se estavel em todos os semestres e areas, havendo necessidade de outras pesquisas para a validacao do instrumento, tendo em vista que ja dispoe de validacao de definicao. Sugere-se a realizacao de novos estudos para ampliacao do conhecimento sobre a tematica. Abstract
Knowledge Transfer for Out-of-Knowledge-Base Entities : A Graph Neural Network Approach

Knowledge base completion (KBC) aims to predict missing information in a knowledge this http URL this paper, we address the out-of-knowledge-base (OOKB) entity problem in KBC:how to answer queries concerning test entities not observed at training time. Existing embedding-based KBC models assume that all test entities are available at training time, making it unclear how to obtain embeddings for new entities without costly retraining. To solve the OOKB entity problem without retraining, we use graph neural networks (Graph-NNs) to compute the embeddings of OOKB entities, exploiting the limited auxiliary knowledge provided at test time.The experimental results show the effectiveness of our proposed model in the OOKB setting.Additionally, in the standard KBC setting in which OOKB entities are not involved, our model achieves state-of-the-art performance on the WordNet dataset. The code and dataset are available at this https URL
Dissemination of High-Risk Clones of Extensively Drug-Resistant Pseudomonas aeruginosa in Colombia

ABSTRACT The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor blaVIM-2 on a class 1 integron and blaKPC-2 on a Tn4401 transposon, respectively. Additionally, P. aeruginosa ST1492, a novel single-locus variant of ST111, was identified. Clonal dissemination and the presence of mobile genetic elements likely explain the successful spread of XDR P. aeruginosa strains in Colombia.
Nueva edad de la base del grupo Chubut en la mena uranífera Cerro Solo, provincia del Chubut

En este trabajo se analizan las caracteristicas litologicas de la roca hospedante de la mineralizacion de uranio del yacimiento Cerro Solo, que corresponde al miembro inferior de la Formacion Los Adobes, unidad basal del Grupo Chubut en su sector norte. Se analiza la asociacion de polen angiospermico de alli recuperada, y en base a ese analisis, se establece una edad albiana temprana para la asociacion polinica, que determina una edad mas joven que la considerada hasta el momento para el inicio de la depositacion de las sedimentitas del Grupo Chubut en el depocentro del yacimiento Cerro Solo.