Miracle-dz/UniFAR-FTUs huggingface dataset:
The Prevalence of Unexpected Sexually Transmitted Diseases in Women with Lower Urinary Tract Complaints Suggestive of UTI is High

Objective: To examine the prevalence of unrecognized sexually transmitted diseases in women who present to the emergency room with urinary complaints, which generally would be treated only for urinary tract infection. Methods: An eight month, prospective study was performed in a community, teaching hospital emergency department. Sexually active women, ages 18-45, who presented with urinary complaints were solicited for participation. Physician-administered questionnaires queried the demographic, gynecologic, obstetric, sexual history, and presenting symptoms. Patient complaints, physical findings, laboratory results (urinalysis, urine culture, serum Venereal Disease Research Laboratory (VDRL), and cervical cultures for Nisseria gonorrhea, Chlamydia trachomatis, and Trichomonas) were reviewed. Results: A total of 49 patients (66% African American, 28% Caucasian, and 6% other) who met the inclusion criteria were enrolled. The mean age of our participants was 25 years. The range of sexual partners in one’s lifetime was 1 to 50, with a mean of 12.8 partners. Forty-eight percent had a history of a Sexually Transmitted Disease (STD) and 18% had active disease (C. trachomatis 8%, syphilis 2%, and Trichomonas 8%). There was no relationship between the history of a STD and positive cultures or recurrent STD. Thirty-four percent were confirmed to have a UTI. Fourteen percent were co-infected with both a STD and a UTI. Conclusion: The prevalence of occult STDs in women presenting with urinary complaints who underwent pelvic examination was 18%. The evidence emphasizes the importance of diagnosing STDs with performing a pelvic examination and culture on sexually active females with nonspecific urinary complaints, who otherwise might be misdiagnosed as having a simple urinary tract infection.
Timing and connectivity in the human somatosensory cortex from single trial mass electrical activity

Parallel‐distributed processing is ubiquitous in the brain but often ignored by experimental designs and methods of analysis, which presuppose sequential and stereotypical brain activations. We introduce here a methodology that can effectively deal with sequential and distributed activity. Regional brain activations elicited by electrical median nerve stimulation are identified in tomographic estimates extracted from single trial magnetoencephalographic signals. Habituation is identified in both primary somatosensory cortex (SI) and secondary somatosensory cortex (SII), often interrupted by resurgence of strong activations. Pattern analysis is used to identify single trials with homogeneous regional brain activations. Common activity patterns with well‐defined connectivity are identified within each homogeneous group of single trials across the subjects studied. On the contralateral side one encounters distinct sets of single trials following identical stimuli. We observe in one set of trials sequential activation from SI to SII and insula with onset of SII at 60 msec, whereas in the other set simultaneous early co‐activations of the same two areas. Hum. Brain Mapping 15:231–246, 2002. © 2002 Wiley‐Liss, Inc.
Pattern of congenital heart diseases in Rwandan children with genetic defects

Introduction Congenital heart diseases (CHD) are commonly associated with genetic defects. Our study aimed at determining the occurrence and pattern of CHD association with genetic defects among pediatric patients in Rwanda. Methods A total of 125 patients with clinical features suggestive of genetic defects were recruited. Echocardiography and standard karyotype studies were performed in all patients. Results CHDs were detected in the majority of patients with genetic defects. The commonest isolated CHD was ventricular septal defect found in many cases of Down syndrome. In total, chromosomal abnormalities represented the majority of cases in our cohort and were associated with various types of CHDs. Conclusion Our findings showed that CHDs are common in Rwandan pediatric patients with genetic defects. These results suggest that a routine echocardiography assessment combined with systematic genetic investigations including standard karyotype should be mandatory in patients presenting characteristic clinical features in whom CHD is suspected to be associated with genetic defect.
Opioid Use After Discharge in Postoperative Patients: A Systematic Review

Background:Over the past 2 decades, there has been an increase in opioid use and subsequently, opioid deaths. The amount of opioid prescribed to surgical patients has also increased. The aim of this systematic review was to determine postdischarge opioid consumption in surgical patients compared with the amount of opioid prescribed. Secondary outcomes included adequacy of pain control and disposal methods for unused opioids. Objective:The objective of this study is to characterize postdischarge opioid consumption and prescription patterns in surgical patients. Methods:A systematic search in MEDLINE and EMBASE identified 11 patient survey studies reporting on postdischarge opioid use in 3525 surgical patients. Results:The studies reported on a variety of surgical operations, including abdominal surgery, orthopedic procedures, tooth extraction, and dermatologic procedures. The majority of patients consumed 15 pills or less postdischarge. The proportion of used opioids ranged from 5.6% to 59.1%, with an outlier of 90.1% in pediatric spinal fusion patients. Measured pain scores of those taking opioids ranged between 2 and 5 out of 10 and the majority of patients were satisfied with their pain control. Seventy percent of patients kept the excess opioids. Where planned disposal methods were reported, between 4% and 59% of patients planned proper disposal. Conclusion:This study suggests that surgical patients are using substantially less opioid than prescribed. There is a lack of awareness regarding proper disposal of leftover medication, leaving excess opioid that may be used inappropriately by the patient or others. Education for providers and clinical practice guidelines that provide guidance on prescription of outpatient of opioids are required.
Siete mitos de los servicios electrónicos

A medida que hemos pasado de la economia post-industrial a la economia de servicios y luego a la economia de servicios y luego a la economia de la experiencia, la revolucion tecnologica ha ofrecido grandes promesas. Este articulo analiza estrategias de comercio minorista en el contexto de Internet y describe en terminos generales siete mitos de los servicios electronicos.
Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D

Abstract: Background: Xenotransplantation could ameliorate the severe shortage of donor organs. The initial results of transplantation from genetically‐modified pig donors to primate recipients suggest that hyperacute rejection can be overcome, but thrombotic microangiopathy and the human anti‐pig cellular immune response remain as significant impediments to successful clinical xenotransplantation. NKG2D is an activating immunoreceptor found on human natural killer (HuNK) cells, CD8+ and γδ T cells. Signaling through NKG2D mediates cytotoxicity and cytokine secretion by NK cells and co‐stimulation of T cells.
Sensitivity of an Ocean General Circulation Model to a Parameterization of Near-Surface Eddy Fluxes

Abstract A simplified version of the near-boundary eddy flux parameterization developed recently by Ferrari et al. has been implemented in the NCAR Community Climate System Model (CCSM3) ocean component for the surface boundary only. This scheme includes the effects of diabatic mesoscale fluxes within the surface layer. The experiments with the new parameterization show significant improvements compared to a control integration that tapers the effects of the eddies as the surface is approached. Such surface tapering is typical of present implementations of eddy transport in some current ocean models. The comparison is also promising versus available observations and results from an eddy-resolving model. These improvements include the elimination of strong, near-surface, eddy-induced circulations and a better heat transport profile in the upper ocean. The experiments with the new scheme also show reduced abyssal cooling and diminished trends in the potential temperature drifts. Furthermore, the need for an.
High platelet volume and increased risk of myocardial infarction: 39 531 participants from the general population

Summary. Background: Active platelets are large and contribute to development of myocardial infarction (MI). Platelet size is measured automatically as mean platelet volume (MPV) together with platelet count. Objectives: We tested the hypothesis that increased MPV is associated with risk of MI in the general population independent of known cardiovascular risk factors. Methods: We examined 39 531 men and woman from the Danish general population (the Copenhagen General Population Study), of whom 1300 developed MI. Results: After multifactorial adjustment for known cardiovascular risk factors, risk of MI was increased by 37% (95% CI, 18–59%) in the middle and 30% (12–52%) in the upper vs. the lower tertile of MPV. Compared with the 1st quintile of MPV, there was corresponding increased risk of MI of 13% (−7% to 39%), 35% (11–64%), 31% (8–59%) and 29% (6–57%) in the 2nd, 3rd, 4th and 5th quintile, respectively. Similar values for octiles were increases in MI risk of −3% (−25% to 26%), 15% (−10% to 46%), 31% (1– 69%), 32% (5–68%), 31% (2–67%), 27% (−1% to 62%) and 26% (−1% to 61%), respectively, in the 2nd through to the 8th octile vs. the 1st octile of MPV. Use of antiplatelet therapy did not modify these risk estimates. Finally, in prospective, multifactorially adjusted analyses, risk of MI increased by 38% (8–75%) in individuals with MPV ≥ 7.4 vs. < 7.4 fL. Conclusions: Increased MPV is associated with increased risk of MI independent of known cardiovascular risk factors.
Radiographic patterns of periodontitis in cats: 147 cases (1998-1999).

OBJECTIVE To determine patterns of alveolar bone loss (periodontitis) and other lesions evident on full-mouth survey radiographs of cats. DESIGN Retrospective study. ANIMALS 147 cats. PROCEDURE Full-mouth radiographs were evaluated for evidence and severity of alveolar bone loss, odontoclastic resorption lesions (ORL), retained roots, missing teeth, signs of endodontic disease secondary to periodontitis, and apical resorption. RESULTS 106 (72%) cats had some degree of periodontitis, 100 (68%) were missing teeth, 98 (67%) had ORL, 78 (53%) had expansion of the buccal alveolar bone at 1 or more canine teeth, 75 (51%) had retained roots, 48 (33%) had apical resorption, and 12 (8%) had signs of endodontic disease secondary to periodontitis. Cats < 4 years old were not significantly more likely than the general population to have normal alveolar bone height. Prevalence of ORL increased with age, but cats > or =13 years old were less likely than the general population to have moderate or severe generalized periodontitis. Purebred cats were not significantly more likely to have periodontitis or ORL than mixed-breed cats. CONCLUSIONS AND CLINICAL RELEVANCE Results suggest that periodontitis is common in cats and that horizontal bone loss is the most common radiographic pattern of alveolar bone loss. Purebred cats were not more likely than mixed-breed cats to have ORL or periodontitis, but when they did have periodontitis, it was more likely to be moderate to severe. Cats with ORL were less likely than cats without ORL to have normal alveolar bone height and more likely to have severe focal vertical bone loss.
Hypercoagulability State in Patients with Chronic Obstructive Pulmonary Disease

Summary Since there is some clinical evidence that the clinical course of patients with chronic obstructive pulmonary disease (COPD) may be complicated by thrombosis in the pulmonary vessels, we studied whether a hypercoagulability state (HS) does occur in COPD. Plasma levels of prothrombin F1+2 fragment, a marker of thrombin generation, D-dimer, a marker of in vivo thrombin and plasmin activation, and fibrinogen were measured in 37 COPD patients and in 30 controls matched for sex and age. COPD patients had significantly higher values of F1+2 (p = 0.0001) and fibrinogen (p = 0.0005) than healthy subjects. The difference persisted after excluding smoking patients. F1+2 was not correlated with PaO2 (r = 0.02, p >0.05) and PaCO2 (p = 0.12, p >0.05). In six patients with stable COPD and F1+2 greater than 1.65 nM (mean + 2SD of controls) subcutaneous calcium-heparin therapy (5000 IU t.i.d. for 15 days) significantly reduced F1+2 (p = 0.03) and PaCO2 (p = 0.01). This study shows that COPD patients have an ongoing prothrombotic state which could potentially account for thrombosis occurring in pulmonary vessels. The effect of calcium-heparin treatment on clotting system activation and blood gas may suggest this treatment as potential candidate for prospective study in COPD patients.
Optimize MinMax algorithm to solve Blokus Duo game by HDL

In this paper, a solution for Blokus Duo game is presented using minmax algorithm. Then, Alpha-beta pruning method is implemented on the algorithm to reduce playing time in the manner that its running speed increases significantly. Moreover, Pentobi® software as a criterion is used as a competitor and the final results for that are reported. All codes are directly written on a hardware basis using VHDL language. After being synthesized by Quartus II®, the result is implemented on DE1-SOC board which uses cyclone V FPGA.
Molecular basis for the binding polyspecificity of an anti‐cholera toxin peptide 3 monoclonal antibody

The onset of autoimmune diseases is proposed to involve binding promiscuity of antibodies (Abs) and T‐cells, an often reported yet poorly understood phenomenon. Here, we attempt to approach two questions: first, is binding promiscuity a general feature of monoclonal antibodies (mAbs) and second, what is the molecular basis for polyspecificity? To this end, the anti‐cholera toxin peptide 3 (CTP3) mAb TE33 was investigated for polyspecific binding properties. Screening of phage display libraries identified two epitope‐unrelated peptides that specifically bound TE33 with affinities similar to or 100‐fold higher than the wild‐type epitope. Substitutional analyses revealed distinct key residue patterns recognized by the antibody suggesting a unique binding mode for each peptide. A database query with one of the consensus motifs and a subsequent binding study uncovered 45 peptides (derived from heterologous proteins) that bound TE33. To better understand the structural basis of the observed polyspecificity we modeled the new cyclic epitope in complex with TE33. The interactions between this peptide and TE33 suggested by our model are substantially different from the interactions observed in the X‐ray structure of the wild‐type epitope complex. However, the overall binding conformation of the peptides is similar. Together, our results support the theory of a general polyspecific potential of mAbs. Copyright © 2005 John Wiley & Sons, Ltd.
Volumetric analysis of the diagonal band of Broca in patients with schizophrenia and affective disorders: A post‐mortem study

The human diagonal band of Broca is connected to other parts of the limbic system, such as the hippocampus, that are involved in the pathology of schizophrenia. This study aimed to characterize the volume and anterior‐to‐posterior distance of the human diagonal band of Broca (vertical limb) from post‐mortem brains obtained from three groups: healthy control subjects (N = 17), patients with schizophrenia (N = 26), and patients with affective disorders (N = 12). There were no significant differences in the volume or anterior‐to‐posterior distance in the patients with schizophrenia or affective disorders compared with the healthy control subjects. To date, this is the first post‐mortem investigation measuring the volume and the anterior‐to‐posterior distance of the diagonal band of Broca (vertical limb) in patients with schizophrenia or affective disorders compared with healthy control subjects. Clin. Anat. 29:466–472, 2016. © 2015 Wiley Periodicals, Inc.
Thermal signature of plumes in turbulent convection: The skewness of the derivative.

We present experimental evidence that, in the hard turbulence regime of Rayleigh-Benard convection, the temperature fluctuations are produced by buoyancy, despite the presence of a mean horizontal flow at the plates. In a convection cell of aspect ratio 1, we measure the temperature time derivative for Ra from 2310 to 1310, which is skewed toward the negative in the region outside the cold thermal boundary layer. This skewness of the derivative indicates the presence of thermal fronts, or plumes, which are detached from the boundary layer by buoyancy. At higher Ra, the skewness of the derivative is reduced, which we relate to the transition to a turbulent Reynolds number in the velocity boundary layer at Ra;10. We define a time scale using the derivative to characterize these fronts, and find that its minimum value scales as Ra over the entire range of Ra in our experiment. @S1063-651X~96! 11405-7#
A 200 µW Eight-Channel EEG Acquisition ASIC for Ambulatory EEG Systems

The growing interest toward the improvement of patients' quality of life and the use of medical signals in nonmedical applications such as entertainment, sports, and brain-computerinterfaces, requires the implementation of miniaturized and wireless biopotential acquisition systems with ultralow power dissipation. Therefore, this paper presents the implementation of a complete EEG acquisition ASIC tailored towards the needs of such applications, i.e., high-signal quality, low-power dissipation and ease of use. The presented ASIC includes eight readout front-end channels and an 11-bit analog-to-digital converter (ADC). The key to its high performance and low-power dissipation is the new AC coupled chopper stabilized instrumentation amplifier (ACCIA) implementation that uses a coarse-fine servoloop and reaches more than 120 dB CMRR, consumes only 2.3 muA , and achieves a noise-efficiency factor (NEF) of 4.3. Furthermore, the ease of use of the ASIC is realized by incorporating Calibration and Electrode Impedance Measurement Modes to the ASIC. Therefore, the former can be used to check the functionality of the ASIC, as well as, to calibrate the gain matching of the channels, where as the latter can be used to track the quality of the biopotential electrode. The ASIC is implemented in 0.5 mum CMOS process and the total current consumption is 66 muA from 3 V.
PARP inhibitor attenuated colony formation can be restored by MAP kinase inhibitors in different irradiated cancer cell lines

Abstract Purpose: Sensitizing cancer cells to irradiation is a major challenge in clinical oncology. We aimed to define the signal transduction pathways involved in poly(ADP-ribose) polymerase (PARP) inhibitor-induced radiosensitization in various mammalian cancer lines. Materials and methods: Clonogenic survival assays and Western blot examinations were performed following telecobalt irradiation of cancer cells in the presence or absence of various combinations of PARP- and selective mitogen-activated protein kinase (MAPK) inhibitors. Results: HO3089 resulted in significant cytotoxicity when combined with irradiation. In human U251 glioblastoma and A549 lung cancer cell lines, Erk1/2 and JNK/SAPK were found to mediate this effect of HO3089 since inhibitors of these kinases ameliorated it. In murine 4T1 breast cancer cell line, p38 MAPK rather than Erk1/2 or JNK/SAPK was identified as the main mediator of HO3089's radiosensitizing effect. Besides the aforementioned changes in kinase signaling, we detected increased p53, unchanged Bax and decreased Bcl-2 expression in the A549 cell line. Conclusions: HO3089 sensitizes cancer cells to photon irradiation via proapoptotic processes where p53 plays a crucial role. Activation of MAPK pathways is regarded the consequence of irradiation-induced DNA damage, thus their inhibition can counteract the radiosenzitizing effect of the PARP inhibitor.
On approximation of real numbers by real algebraic numbers

1. Introduction. In this paper we consider several related problems of the theory of Diophantine approximation. The following notation will be used. We denote by #S the number of elements in a finite set S. The Lebesgue measure of a measurable set S R is denoted by |S|. The set S R has full measure means that |R\ S| = 0. Throughout the paper, denotes a monotonic sequence of positive numbers. We denote by Pn the set of integral polynomials of degree n. The set of real algebraic numbers of degree n is denoted byAn. Given a polynomial P , H(P ) denotes the height of P . Given an algebraic number , H( ) denotes the height of . We use the Vinogradov symbol , which means “ up to a constant multiplier”. We begin with a short review. In 1924 Khinchin proved a remarkable result on the approximation of real numbers by rationals [9]. According to his theorem, for almost all x2R the inequality
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA‐damage‐response proteins

ATM/ATR‐like protein kinases play central roles in the maintenance of genome stability and phosphorylate numerous substrates in response to DNA damage, preferentially on SQ or TQ motifs. ATM/ATR substrates often contain several closely spaced SQ/TQ motifs in regions that have been termed SQ/TQ cluster domains (SCDs). SCDs are now considered a structural hallmark of DNA‐damage‐response proteins. Mutational analyses of a number of SCD‐containing proteins indicate that multisite phosphorylation of SQ/TQ motifs is required for normal DNA‐damage responses, most commonly by mediating protein–protein interactions in the formation of DNA‐damage‐induced complexes. SCD sequences are highly diverse and these domains may be largely unfolded in their native state rather than adopting a common three‐dimensional fold. Structural disorder of SCDs could be advantageous for efficient phosphorylation by ATM/ATR kinases and also enable them to be molded into distinct conformations to facilitate flexible interactions with multiple binding partners. BioEssays 27:397–407, 2005. © 2005 Wiley periodicals, Inc.
Intensity of pain due to separators in adolescent orthodontic patients

Objective: To investigate the intensity of pain adolescent orthodontic patients experience following the insertion of separators. Materials and Methods: Elastomeric separators were placed mesially and distally to the first molars in 62 adolescents (20 male, 42 female, age 12–15 years), and the participants were given self-administrated questionnaires to document perceived pain, pain upon chewing, and the severity of pain's affecting daily life, using a visual analog scale for seven days. Results: The mean perceived pain scores out of 100 on the first 3 days were 54.6 ± 32.7, 51.7 ± 29.9, and 32.3 ± 28.4, respectively; chewing pain scores were: 61.9 ± 35.3, 52.6 ± 30.4, and 39.5 ± 32.1, respectively; the pain's affecting daily life scores were 24.9 ± 35.5, 21.1 ± 30.9, and 11.9 ± 23.7, respectively. A Kruskal–Wallis test showed a statistically significant difference in the reported pain between the three studied parameters. A Mann–Whitney U-test showed an insignificant difference between male and female adolescents. Conclusion: Pain perception varies among adolescent patients, but it decreases significantly after the first 2 days, with no gender differences.