Miracle-dz/UniFAR-FTUs huggingface dataset:
Successful switch to oral tacrolimus in a patient with hypersensitivity reaction to parenteral vitamin K, cyclosporine, and tacrolimus: A case report

Introduction Calcineurin inhibitors are widely used for the prevention and treatment of graft versus host disease in patients undergoing allogeneic hematopoietic stem cell transplantation, and successful treatment with calcineurin inhibitors is very important for the management of these cases. Case report A 19-year-old man with thalassemia major experienced hypersensitivity reaction to parenteral vitamin K, cyclosporine, and tacrolimus before hematopoietic stem cell transplantation. All three episodes of reaction appeared a few minutes after administration of offended drugs and cause systemic signs and symptoms of anaphylaxis, i.e. itching, flushing, difficulty in breathing, and hypotension. Management and outcome Hypersensitivity reaction was fully controlled by immediately discontinuing the drug and administering hydrocortisone, chlorpheniramine, epinephrine, and intravenous fluids. During hospitalization, the patient tolerated oral tacrolimus without any complication. Discussion It appears that Cremophor EL (polyoxyethylated castor oil) which acts as a carrier, solubilizer, and emulsifier in intravenous calcineurin inhibitors is responsible for the occurrence of anaphylactic reaction (anaphylaxis); therefore, it is suggested that the administration of cremophor-containing drug should be avoided in patients with a previous history of hypersensitivity reaction to one of these drugs.
Content of inpatient rehabilitation for patients with traumatic brain injury: A comparison of Canadian and American facilities

ABSTRACT Objective: To compare components of inpatient rehabilitation (IR) for patients with traumatic brain injury (TBI) between Canada and the US facilities. Design: Secondary analysis of the TBI-practice-based evidence dataset. Participants: Patients with TBI who had a higher Functional Independence Measure (FIMTM) cognitive function score (≥21) that were admitted to 1 IR facility in Canada (n = 103) and 9 IR facilities in the US (n = 401). Main measures: demographic and clinical characteristics, type and intensity of activities by discipline, discharge location, FIM-Rasch score, social participation and quality of life. Results: Time from injury to rehabilitation admission was significantly longer in the Canadian cohort and they experienced a longer rehabilitation length of stay (p < .001, Cohen’s d > .8). Patients in Canada received a greater total time of individual therapy and lower intensity of interventions per week from all disciplines. They also showed a higher score at discharge in FIM components, while US patients had better cognitive recovery and community participation long-term post-discharge. Conclusions: This study informs stakeholders of the large variation in service provision for patients who were treated in these two countries. These findings suggest the need for robust analyzes to investigate predictors of short and long-term outcomes considering the variation in health-care delivery. List of abbreviations: TBI: traumatic brain injury, CSI: comprehensive severity index, LoS: length of stay, OT: occupational therapy, PT: physical therapy, SLP: speech language pathology, IR: inpatient rehabilitation
Efficacy and safety of neoadjuvant chemotherapy regimens for triple-negative breast cancer: a network meta-analysis

Different neoadjuvant chemotherapies are available for triple-negative breast cancer (TNBC). Here, we performed a network meta-analysis to evaluate the pathological complete response (pCR) benefit and safety of treatment regimens. Pairwise and Bayesian network meta-analyses were performed to compare direct and indirect evidence, respectively. Twenty-three studies involving 12 regimens namely standard chemotherapeutic agents, bevacizumab (B)-, platinum salts (P)-, B plus P (BP)-, poly(ADP-ribose) polymerase inhibitors (Pi)-, P plus Pi (PPi)-, capecitabine (Ca)-, gemcitabine (Ge)-, zoledronic acid (Za)-, everolimus (E)-, P plus E (PE)-, and gefitinib (G)-containing regimens. The results showed that P-, B-, PPi-, and Za-containing regimens achieved higher pCR than standard chemotherapeutic agents. BP-containing regimens had a better pCR than B-containing regimens. In indirect comparisons, Za-, BP-, P-, and B-containing regimens were the top four strategies with the highest probability for pCR. Benefit-risk analysis showed that B-containing regimens had the highest acceptability of being the best treatment for better pCR achievement with fewer SAEs. The addition of P, B, BP, PPi, and Za to standard chemotherapeutic agents enhanced the pCR, but a balance between efficacy and safety should be carefully considered. B-containing regimens might be the best choice for neoadjuvant chemotherapy due to its better efficacy and tolerability.
Seeking God’s Will: The Experience of Information Seeking by Leaders of a Church in Transition/À la recherche de la volonté de Dieu : L’expérience de recherche d’information des dirigeants d’une Église en transition

What is the experience of information seeking (IS) by leaders of a church in transition, as they seek the will of God for their church? In this ethnographic pilot study, I begin to create a picture of leaders’ information seeking, first for personal faith building and then for corporate decision making, and I consider the impact of new technologies on these processes. Religious IS did not differ significantly from other everyday-life information seeking (ELIS) experiences, except when subjects were acting in leadership roles. Prominent themes were theological diversity and prayer. Quelle est l’expérience de recherche d’information des dirigeants d’une église en transition, tandis qu’ils sont en quête de la volonté de Dieu pour leur église ? Dans cetteétude ethnographique pilote, je tente d’élaborer une image de la recherche d’information des dirigeants, d’abord pour l’édification de leur foi personnelle, puis pour leurs prises de décisions corporatives, et j’examine l’impact des nouvelles technologies sur ces processus. La recherche d’information religieuse ne diffère pas significativement des expériences de recherche d’information de la vie quotidienne, sauf dans les rôles de leadership. Les thèmes importants ont été la diversité théologique et la prière.
HIV infection in urological practice

The present review investigates the association between the presence of urological disorders and the transmission of human immunodeficiency virus (HIV). This study suggests that sexually transmitted infections (STIs) can increase the risk of infecting sexual partner or being infected with HIV. However, community-based STI control was not proved to be an effective HIV prevention strategy, although a few clinical trials revealed the possibility that aggressive treatment of STIs could decrease the transmission of HIV in specific population groups. Since the introduction of highly active antiretroviral therapy (HAART), HIV infection has become a chronic disease. Antiretroviral medications also were shown to be effective for the pre-exposure and post-exposure prophylaxis of HIV infection. Urologists should perform a critical role in preventing transmission of HIV by screening of HIV in the patients with urological disorders and using effective strategies to control the HIV epidemic.
Prepared for submission to JHEP Resurgence for superconductors

An important non-perturbative effect in quantum physics is the energy gap of superconductors, which is exponentially small in the coupling constant. A natural question is whether this effect can be incorporated in the theory of resurgence. In this paper we take some steps in this direction. We conjecture that the perturbative series for the ground state energy of a superconductor is factorially divergent, and that its leading Borel singularity is governed by the superconducting energy gap. We test this conjecture in detail in the attractive Gaudin-Yang model, an exactly solvable model in one dimension with a BCS-like ground state. In order to do this, we develop techniques to calculate the exact perturbative series of its ground state energy up to high order. We also argue that the Borel singularity is of the renormalon type, and we identify a class of diagrams leading to factorial growth. We give additional evidence for the conjecture in other models. ar X iv :1 90 5. 09 56 9v 1 [ he pth ] 2 3 M ay 2 01 9
Morphometric analysis of vidian canal and its relations with surrounding anatomic structures by using cone beam computed tomography.

BACKGROUND We identified the vidian canal (VC) in a Turkish subpopulation on cone-beam computed tomography (CBCT) images and explored its anatomic relationships; the canal serves as an anatomic pathway during endonasal surgical approaches. MATERIALS AND METHODS Coronal and axial CBCT images of 100 patients (50 males and 50 females) were evaluated (slice thickness and interval, 0.5 mm). We measured the length of the VC length, extent of VC pneumatization into the sphenoid sinus, position of the VC relative to the medial pterygopalatine plate (MPP), pterygopalatine fossa (PPF) depth, and VC-VC, VC-MPP, and VC-foramen rotundum (FR) distances, the angle between the posterior end of the middle turbinate and the lateral part of the VC anterior opening, and the angle between the VC and the palatovaginal canal. RESULTS The mean VC length was 13.09 ± 2.07 and 13.01 ± 2.12 mm on the right and left sides, respectively. Relative to the MPP, the VC was located medially in 54.5% of patients, on the same level in 36%, and laterally in 9.5%. Pneumatization was of grade I in 24% of patients, grade II in 33%, grade III in 23.5%, and grade IV in 19.5%. The VC-FR and VC-MPP distances were significantly greater on the left side. The angle between the posterior end of the middle turbinate and the lateral part of the anterior VC opening was significantly greater on the right side. The VC-VC distance was significantly greater when the VC lay lateral to the MPP. CONCLUSIONS Anatomic characteristics of the VC on CBCT images unique to Turkish populations should be kept in mind during surgery.
Simulated Volume-Based Regionalization of Complex Procedures

Objective: This study simulates the regionalization of pancreatectomies to assess its impact on spatial access in terms of patient driving times. Background: Although policies to regionalize complex procedures to high-volume centers may improve outcomes, the impact on patient access is unknown. Methods: Patients who underwent pancreatectomies from 2005 to 2014 were identified from California's statewide database. Round-trip driving times between patients’ home ZIP code and hospital addresses were calculated via Google Maps. Regionalization was simulated by eliminating hospitals performing <20 pancreatectomies/yr, and reassigning patients to the next closest hospital that satisfied the volume threshold. Sensitivity analyses were performed for New York and Medicare patients to assess for influence of geography and insurance coverage, respectively. Results: Of 13,317 pancreatectomies, 6335 (47.6%) were performed by hospitals with <20 cases/yr. Patients traveled a median of 49.8 minutes [interquartile range (IQR) 30.8–96.2] per round-trip. A volume-restriction policy would increase median round-trip driving time by 24.1 minutes (IQR 4.5–53.5). Population in-hospital mortality rates were estimated to decrease from 6.7% to 2.8% (P < 0.001). Affected patients were more likely to be racial minorities (44.6% vs 36.5% of unaffected group, P < 0.001) and covered by Medicaid or uninsured (16.3% vs 9.8% of unaffected group, P < 0.001). Sensitivity analyses revealed a 17.8 minutes increment for patients in NY (IQR 0.8–47.4), and 27.0 minutes increment for Medicare patients (IQR 6.2–57.1). Conclusions: A policy that limits access to low-volume pancreatectomy hospitals will increase round-trip driving time by 24 minutes, but up to 54 minutes for 25% of patients. Population mortality rates may improve by 1.5%.
Children of the Land: Adversity and Success in Rural America (review)

As a now historical case study, Gordy’s book provides much useful information. Gordy devotes substantive chapters to the destruction of political, information, and musical alternatives, as well as to sociability. In each, he discusses geographically (urban-rural) and generationally differentiated responses to the regime. The Culture of Power in Serbia is more descriptively rich than analytically compelling. Generally, it is an uneven work that would have benefited from closer editorial guidance. For example, the chapter on music cultures is considerably more developed and novel than the others and brings a welcome dimension to the study of authoritarian (nationalist) regimes. Yet it is unclear why there is no discussion of other expressive cultural forms such as theater, art, or literature. Stylistically, there are striking redundancies, arbitrary usage of Serbian words, and so on. More unsatisfying, Gordy does not situate his theoretical argument in the broader context of the region’s processes of regime transformation, whether “velvet” or violent. As such, Gordy’s case study may seem too specialized for many readers. Nonetheless, The Culture of Power in Serbia itself presents an alternative political sociological/cultural reading of the Milosevic regime’s tenacity that contributes to the interdisciplinary literature on the the role of the “state against society,” and of civil society against the state. In the end, after thirteen long years, the power of culture in Serbia seems to have prevailed over Milosevic’s culture of power.
Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review.

OBJECTIVE Alcohol use disorder (AUD) is a complex, dynamic condition that waxes and wanes with unhealthy drinking episodes and varies in drinking patterns and effects on brain structure and function with age. Its excessive use renders chronically heavy drinkers vulnerable to direct alcohol toxicity and a variety of comorbidities attributable to nonalcohol drug misuse, viral infections, and accelerated or premature aging. AUD affects widespread brain systems, commonly, frontolimbic, frontostriatal, and frontocerebellar networks. METHOD AND RESULTS Multimodal assessment using selective neuropsychological testing and whole-brain neuroimaging provides evidence for AUD-related specific brain structure-function relations established with double dissociations. Longitudinal study using noninvasive imaging provides evidence for brain structural and functional improvement with sustained sobriety and further decline with relapse. Functional imaging suggests the possibility that some alcoholics in recovery can compensate for impairment by invoking brain systems typically not used for a target task but that can enable normal-level performance. CONCLUSIONS Evidence for AUD-aging interactions, indicative of accelerated aging, together with increasing alcohol consumption in middle-age and older adults, put aging drinkers at special risk for developing cognitive decline and possibly dementia. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
Phenotype and Risk Burden of Sleep Apnea.

Sleep apnea (SA) prevalence had increased. The socioeconomic burden is significant because of healthcare-related costs and adverse outcome, especially in moderate-to-severe SA. However, the population impact is unclear, particularly for mild SA. We aimed to assess the current prevalence and the cardiovascular risk associates of SA in the general population. We performed home polygraphy and extensive clinical, sociodemographic, and cardiovascular assessment in 2205 eligible subjects from a population-based cohort. Successful polygraphy was obtained in 1809 subjects (mean age, 56.0; SD, 5.9 years; 52.3% women). The prevalence was 41.0%, 11.8%, and 6.5% for mild, moderate, and severe SA in men and 26.6%, 4.4%, and 1.2% in women. Male sex, age, increasing BMI, and snoring were independently associated with SA, whereas sleepiness or tiredness were not. Compared with those without SA, mild SA was associated with (age- and sex-adjusted OR; 95% CI): diabetes mellitus (2.40; 1.52-3.80), hypertension (1.76; 1.42-2.19), left ventricular hypertrophy (1.36; 1.03-1.79), arterial plaques (1.19; 0.94-1.52), and increased IL-6 (interleukin-6) levels (1.37; 1.10-1.72). These associations were more pronounced in moderate-to-severe SA. To conclude, SA is highly prevalent in the middle-aged general population. It is largely undetected and undetectable using a symptom-based strategy. Yet, even the large group with mild SA shows a manifestly higher metabolic, inflammatory, and cardiovascular risk factor burden, with potential public health implications.
Running head: MOTIVATION, PHYSICAL ACTIVITY AND DISABILITY Motivation for physical activity in young adults with a physical disability during a rehabilitation stay: A longitudinal test of Self-Determination Theory

We tested a Self-Determination Theory process model (SDT; Deci & Ryan, 2000) during a 3week physical activity rehabilitation stay among young adults with a physical disability (N = 44, Mage = 24.7, SD = 5.1). As hypothesized, perceived autonomy support positively predicted needs satisfaction at the end of the stay (r = .38, p <.01). Further, needs satisfaction was positively linked to changes in autonomous motivation for physical activity (r = .47, p <.01). Both changes in autonomous motivation and self-efficacy were associated with physical activity increases over the stay (r = .57, p <.01 and r =. 47, p <.01, respectively). Bootstrapping results supported the SDT process-model, indicating a support for a development towards more self-determined motivation in rehabilitation.
Semen and reproductive hormone parameters in fertile men with and without varicocele

Although varicoceles are a widely accepted identifiable male factor in infertile couples, the benefit of varicocele repair in improving pregnancy and live birth rates remains uncertain. The Study for Future Families obtained semen and reproductive hormone samples from US men whose partners were currently pregnant. In our analysis cohort of 709 men, a varicocele was detected by clinical examination in 56 (8%) of men. Men with varicocele had smaller left testis, and lower total and total motile sperm counts than men without varicocele. Gonadotropin levels were higher as well in men with varicocele. Interestingly, testosterone levels were also slightly higher in men with varicocele. Despite these differences, there was no difference between the groups in the time to achieve the study pregnancy or percentage of men with a previous pregnancy. We conclude that even in fertile men, varicoceles are associated with some degree of testicular hypofunction. This would support current recommendations to consider varicocele repair in male partners in infertile couples who demonstrate both a varicocele and abnormal semen parameters and after evaluation for treatable female factors.
Transfer Is Associated with a Higher Mortality Rate in Necrotizing Soft Tissue Infections.

Background: Necrotizing soft tissue infections (NSTI) are a surgical emergency with significant morbidity and mortality rates. It has been thought that NSTIs are best treated in large tertiary centers. However, the effect of transfer has been under-studied. We examined whether transfer status is associated with a higher mortality rate in NSTIs. Methods: We conducted a retrospective review of patients with an International Classification of Disease (ICD) code associated with NSTI seen from 2012-2015 at two tertiary care institutions. Patients transferred to a tertiary center (T-NSTI) were compared with those who were treated initially at a tertiary center (P-NSTI). The primary endpoint was in-hospital death. Results: A total of 138 patients with NSTI met our study criteria, 39 transfer patients (28.0%) and 99 (72.0%) who were treated primarily at our institutions. The mortality rate was significantly higher for T-NSTI patients than P-NSTI patients (35.9% versus 14.1%; p < 0.01) with an adjusted odds ratio of 5.33 (95% confidence interval 1.02-28.30; p = 0.04). The need for hemodialysis was an independent predictor of in-hospital death. Treatment at a Level 1 trauma center and current smoking status were independent protectors? of in-hospital death. For the transfer patients, the timing of transfer and debridement status were not different in survivors and non-survivors. However, there was a trend toward a lower in-hospital mortality rate if patients were transferred early without prior debridement than in all other transfers (21.4% versus 40.0%; p = 0.21). The in-hospital mortality rate was significantly lower at the Level 1 trauma center than at the non-trauma tertiary center (15.5% versus 34.3%; p = 0.02). Conclusion: Transfer status is an independent predictor of in-hospital death in patients with NSTI. Larger, multi-institutional studies are needed to elucidate further what factors contribute to the higher mortality rate in these patients.
Prevalence and Correlates of Meeting Sleep, Screen-Time, and Physical Activity Guidelines Among Adolescents in the United Kingdom.

Author Contributions: Ms Wille and Dr Parent had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Concept and design: All authors. Acquisition, analysis, or interpretation of data: Parent. Drafting of the manuscript: All authors. Critical revision of the manuscript for important intellectual content: All authors. Statistical analysis: All authors. Administrative, technical, or material support: Wille. Supervision: Parent.
Does your trust in strangers or close acquaintances promote better health? Societal residential mobility matters

ABSTRACT Some studies indicated that different types of trust are qualitatively different psychological experiences, which may lead to different health outcomes. The present study examined the effect of two types of trust, i.e., generalized trust and interpersonal trust, on promoting physical health and subjective well-being in regions varying in societal residential mobility. The data from a nationally representative sample, including 10,968 participants from 28 provinces/municipalities in China, were analyzed. The results showed that the negative relationship between generalized trust and depressed mood was stronger in the regions with higher societal residential mobility whereas the positive relationship between interpersonal trust and physical health and the negative relationship between interpersonal trust and depressed mood were stronger in the regions with lower societal residential mobility. These results highlight the importance of socio-ecological characteristics in understanding the adaptive functions of different types of social capital on health outcomes. (143 words; max: 150 words)
COMPARATIVE SELECTIVITY OF HERBICIDES USED IN WHEAT CROP ON THE PREDATORS Chrysoperla externa AND Eriopis connexa

The selectivity of eight herbicides registered for use in the wheat crop was assessed on the predators Chrysoperla externa and Eriopis connexa. Bioassays were conducted in the laboratory by exposing larvae, eggs, and pupae of these predators to dry residues of the herbicides 2,4-D amine, bentazon, glyphosate 1.200, glyphosate 1.440, ammonium glufosinate, iodosulfuron-methyl, metsulfuron-methyl, and pyrimidinedione. The herbicide ammonium glufosinate was classified as moderately harmful (class 3) to the larval stage of both predators. In the egg stage, only metsulfuron-methyl showed a reduction in larval hatching higher than 30% and was classified as slightly harmful (class 2) to eggs of E. connexa. The herbicide 2,4-D amine was classified as slightly harmful (class 2) to pupae of C. externa, while pyrimidinedione presented the same classification to pupae of E. connexa. The herbicides bentazon, glyphosate 1.200, glyphosate 1.440, and iodosulfuron-methyl were considered as innocuous to the stages of larva, egg, and pupa of C. externa and E. connexa and can be used in the integrated pest management of wheat crop, assisting in predator conservation.