Miracle-dz/UniFAR-FTUs huggingface dataset:
An association study revealed substantial effects of dominance, epistasis and substance dependence co‐morbidity on alcohol dependence symptom count

Alcohol dependence is a complex disease involving polygenes, environment and their interactions. Inadequate consideration of these interactions may have hampered the progress on genome‐wide association studies of alcohol dependence. By using the dataset of the Study of Addiction: Genetics and Environment with 3838 subjects, we conducted a genome‐wide association studies of alcohol dependence symptom count (ADSC) with a full genetic model considering additive, dominance, epistasis and their interactions with ethnicity, as well as conditions of co‐morbid substance dependence. Twenty quantitative trait single nucleotide polymorphisms (QTSs) showed highly significant associations with ADSC, including four previously reported genes (ADH1C, PKNOX2, CPE and KCNB2) and the reported intergenic rs1363605, supporting the overall validity of the analysis. Two QTSs within or near ADH1C showed very strong association in a dominance inheritance mode and increased the phenotype value of ADSC when the effect of co‐morbid opiate or marijuana dependence was controlled. Highly significant association was also identified in variants within four novel genes (RGS6, FMN1, NRM and BPTF), two non‐coding RNA and two epistasis loci. QTS rs7616413, located near PTPRG encoding a protein tyrosine phosphatase receptor, interacted with rs10090742 within ANGPT1 encoding a protein tyrosine phosphatase in an additive × additive or dominance × additive manner. The detected QTSs contributed to about 20 percent of total heritability, in which dominance and epistasis effects accounted for over 50 percent. These results demonstrated that perturbations arising from gene–gene interaction and conditions of co‐morbidity substantially influence the genetic architecture of complex trait.
PENGARUH KEPEMILIKAN INSTITUSIONAL, PROPORSI DEWAN KOMISARIS, LEVERAGE, UKURAN PERUSAHAAN DAN RETURN ON ASSET TERHADAP PENGHINDARAN PAJAK PADA PERUSAHAAN MANUFAKTUR

The objective of this study is to examine the effect of institusional ownership, proportion of independent board commissioners, leverage, firm size and return on asset on tax avoidance. Measurement of tax avoidance in this study using multiple measure, Cash Effective Tax Rate (CETR) and Effective Tax Rate (ETR). Using multiple measure aimed to streghten the result of study. This study conducted at the manufacturing companies listed on the Indonesian stock exchange in the observation 2012-2015. 233 companies used as sample that collect by purposive sampling methode. Technic analysis that used in this study is multiple regresion analysis that measured by IBM SPSS statistika 22. The result found that institusional ownership, leverage, firm size and return on asset had simultanous significant impact to tax avoidance. Proportion of independent board commissioners found the different result, both of them not significant influence to tax avoidance. Key Words: Tax Avoidance, Institusional Ownership, Proportion of Independent Board Commissioners, Leverage, Firm Size and Return on Asset
Overexpression of Lamin B Receptor Results in Impaired Skin Differentiation

Hutchinson-Gilford progeria syndrome (HGPS) is a rare segmental progeroid disorder commonly caused by a point mutation in the LMNA gene that results in the increased activation of an intra-exonic splice site and the production of a truncated lamin A protein, named progerin. In our previous work, induced murine epidermal expression of this specific HGPS LMNA mutation showed impaired keratinocyte differentiation and upregulated lamin B receptor (LBR) expression in suprabasal keratinocytes. Here, we have developed a novel transgenic animal model with induced overexpression of LBR in the interfollicular epidermis. LBR overexpression resulted in epidermal hypoplasia, along with the downregulation and mislocalization of keratin 10, suggesting impaired keratinocyte differentiation. Increased LBR expression in basal and suprabasal cells did not coincide with increased proliferation. Similar to our previous report of HGPS mice, analyses of γH2AX, a marker of DNA double-strand breaks, revealed an increased number of keratinocytes with multiple foci in LBR-overexpressing mice compared with wild-type mice. In addition, suprabasal LBR-positive cells showed densely condensed and peripherally localized chromatin. Our results show a moderate skin differentiation phenotype, which indicates that upregulation of LBR is not the sole contributor to the HGPS phenotype.
Plio–Quaternary Geometry and Kinematics of Ptolemais Basin (Northern Greece): Implications for the Intra-Plate Tectonics in Western Macedonia

Geological evidence in the Hellenic orogenic belt of eastern Mediterranean confirms complex Neogene– Quaternary tectonic processes, both in the orogenic front of the Central and South Aegean, and in the backarc domain of the North Aegean and Western Macedonia (STEWART & HANCOCK, 1991; PIPER & PERISSORATIS, 2003; KREEMER et al., 2004; DIAMANTOPOULOS, 2004; OCAKOGLOU et al., 2005). These observations make evident the importance of heterogenous strain, including co-existence of strike-slip, rotational and ductile structures. Since deformation and strain outline three-dimensional quantities, structural heterogeneity from the lithospheric-scale to the grainscale of observation mark an essential constituent of strain (JONES et al., 2005; DE PAOLA et al., 2005). This work analyzes the Plio–Quaternary structures and the deformation style in the Ptolemais basin of Plio–Quaternary Geometry and Kinematics of Ptolemais Basin (Northern Greece): Implications for the Intra-Plate Tectonics in Western Macedonia
Virtual communities as a resource for the development of OSS projects: the case of Linux ports to embedded processors

Open source software (OSS) projects represent a new paradigm of software creation and development based on hundreds or even thousands of developers and users organised in the form of a virtual community. The success of an OSS project is closely linked to the successful organisation and development of the virtual community of support. The main objective of this article is to analyse the activity of virtual communities. Social network analysis is employed to analyse Linux ports to embedded processors as a case study to achieve this aim. The obtained results confirm the necessity of structuring the virtual community with a selection of active developers and core members to promote community activity and attract peripheral users, expanding the impact of the underlying software. The obtained result will be useful for the software industry migrating to the open source software paradigm.
Snakes, spiders, guns, and syringes: How specific are evolutionary constraints on the detection of threatening stimuli?

In three experiments, the efficiency in detecting fear-relevant and fear-irrelevant visual stimuli are compared. A visual search paradigm is used where participants are presented with matrices of different sizes (4 objects/9 objects) and must determine whether all objects are taken from the same category or whether there is a discrepant one. Results from all experiments were consistent with the threat-superiority effect. Participants were quicker when the target was threatening than when it was not. Other indicators confirmed that the detection of threatening targets involves more efficient processes (reduced slopes, absence of position effects). A crucial aspect of these experiments was the comparison of evolutionary-relevant (snakes, spiders, etc.) and modern (guns, syringes, etc.) threats. The threat-superiority effect was repeatedly found for both types of target. Stronger effects were sometimes observed for modern than for evolutionary-relevant threats. The implications for evolutionary explanations of the effect of fear on visual attention are discussed.
A Collaborative Filtering-Based Two Stage Model with Item Dependency for Course Recommendation

Recommender systems have been studied for decades with numerous promising models been proposed. Among them, Collaborative Filtering (CF) models are arguably the most successful one due to its high accuracy in recommendation and elimination of privacy-concerned personal meta-data from training. This paper extends the usage of CF-based model to the task of course recommendation. We point out several challenges in applying the existing CF-models to build a course recommendation engine, including the lack of rating and meta-data, the imbalance of course registration distribution, and the demand of course dependency modeling. We then propose several ideas to address these challenges. Eventually, we combine a two-stage CF model regularized by course dependency with a graph-based recommender based on course-transition network, to achieve AUC as high as 0.97 with a real-world dataset.
Determination of Industrial Competitiveness on Manufacturing Industry Growth in Palembang City

The purpose of this study is to determine the determinants of industrial competitiveness that affect the growth of manufacturing industries in Indonesia. So that there is a paradigm shift in the business climate that surrenders the decision mechanism entirely to the market and then emerges competition in the business world that is increasingly tight with all the risks. Various products and services from within and outside the country can easily be found side by side, ready to compete with each other. With the rapid changes and increasingly fierce competition, only companies that have competitiveness will be able to survive. Whereas companies that do not have competitiveness will automatically "fade" because they cannot compete with other companies. This study shows that the determinants of competitiveness affect the growth of manufacturing industry in Indonesia significantly.
Night-to-night arousal variability and interscorer reliability of arousal measurements.

STUDY OBJECTIVES Measurement of arousals from sleep is clinically important, however, their definition is not well standardized, and little data exist on reliability. The purpose of this study is to determine factors that affect arousal scoring reliability and night-to-night arousal variability. DESIGN The night-to-night arousal variability and interscorer reliability was assessed in 20 subjects with and without obstructive sleep apnea undergoing attended polysomnography during two consecutive nights. Five definitions of arousal were studied, assessing duration of electroencephalographic (EEG) frequency changes, increases in electromyographic (EMG) activity and leg movement, association with respiratory events, as well as the American Sleep Disorders Association (ASDA) definition of arousals. SETTING NA. PATIENTS NA. INTERVENTIONS NA. RESULTS Interscorer reliability varied with the definition of arousal and ranged from an Intraclass correlation (ICC) of 0.19 to 0.92. Arousals that included increases in EMG activity or leg movement had the greatest reliability, especially when associated with respiratory events (ICC 0.76 to 0.92). The ASDA arousal definition had high interscorer reliability (ICC 0.84). Reliability was lowest for arousals consisting of EEG changes lasting <3 seconds (ICC 0.19 to 0.37). The within subjects night-to-night arousal variability was low for all arousal definitions CONCLUSION In a heterogeneous population, interscorer arousal reliability is enhanced by increases in EMG activity, leg movements, and respiratory events and decreased by short duration EEG arousals. The arousal index night-to-night variability was low for all definitions.
Cannabinoid derivatives exert a potent anti‐myeloma activity both in vitro and in vivo

Although hematopoietic and immune system show high levels of the cannabinoid receptor CB2, the potential effect of cannabinoids on hematologic malignancies has been poorly determined. Here we have investigated their anti‐tumor effect in multiple myeloma (MM). We demonstrate that cannabinoids induce a selective apoptosis in MM cell lines and in primary plasma cells of MM patients, while sparing normal cells from healthy donors, including hematopoietic stem cells. This effect was mediated by caspase activation, mainly caspase‐2, and was partially prevented by a pan‐caspase inhibitor. Their pro‐apoptotic effect was correlated with an increased expression of Bax and Bak, a decrease of Bcl‐xL and Mcl‐1, a biphasic response of Akt/PKB and an increase in the levels of ceramide in MM cells. Inhibition of ceramide synthesis partially prevented apoptosis, indicating that these sphingolipids play a key role in the pro‐apoptotic effect of cannabinoids in MM cells. Remarkably, blockage of the CB2 receptor also inhibited cannabinoid‐induced apoptosis. Cannabinoid derivative WIN‐55 enhanced the anti‐myeloma activity of dexamethasone and melphalan overcoming resistance to melphalan in vitro. Finally, administration of cannabinoid WIN‐55 to plasmacytoma‐bearing mice significantly suppressed tumor growth in vivo. Together, our data suggest that cannabinoids may be considered as potential therapeutic agents in the treatment of MM.
The global information technology report 2014

Executive summary When The Global Information Technology Report (GITR) and the Networked Readiness Index (NRI) were created more than 13 years ago, the attention of decision makers was focused on how to develop strategies that would allow them to benefit from what Time Magazine had described as “the new economy”: a new way of organizing and managing economic activity based on the new opportunities that the Internet provided for businesses. At present, the world is slowly emerging from one of the worst financial and economic crises in decades, and policymakers, business leaders, and civil society are looking into new opportunities that can consolidate growth, generate new employment, and create business opportunities. Information and communication technologies (ICTs) continue to rank high on the list as one of the key sources of new opportunities to foster innovation and boost economic and social prosperity, for both advanced and emerging economies. For more than 13 years, the NRI has provided decision makers with a useful conceptual framework to evaluate the impact of ICTs at a global level and to benchmark the ICT readiness and usage of their economies.
Divergence at Cyt-b and Co-1 mtDNA genes on different taxonomic levels and genetics of speciation in animals

Genetic divergence estimates using p-distances and similar measures were generated for 20,731 vertebrate and invertebrate animal species. The results of this analysis demonstrate that the data series are realistic and interpretable when the p-distance and its various derivates are used. The focus is on vertebrates and fish species in particular and the newest data set. Distance data reveal increasing levels of genetic divergence of the sequences of the two genes, cytochrome b (Cyt-b) and cytochrome c oxidase subunit 1 (Co-1), in the five groups compared: populations within species; subspecies, semi-species, or/and sibling species; species within a genus; species from different genera within a family; and species from separate families within an order. Mean unweighted scores of p-distances (%) for these five groups are Cyt-b—1.38 ± 0.30, 5.10 ± 0.91, 10.31 ± 0.93, 17.86 ± 1.36, and 26.36 ± 3.88, respectively; and Co-1—0.89 ± 0.16, 3.78 ± 1.18, 11.06 ± 0.53, 16.60 ± 0.69, and 20.57 ± 0.40, respectively. The estimates show good correspondence with other analyses. These results testify to the applicability of p-distance for most intra-species and inter-species comparisons of genetic divergence up to the order level in animals for the two genes compared. Data reviewed provide empirical and theoretical background on the geographic speciation mode prevalence in species origin and give a framework why per-individual species identification (DNA barcoding) is usually successful.
Alteration in Lipid and Protein Profiles of Ovarian Cancer: Similarity to Breast Cancer

Abstract This study was undertaken to evaluate protein and lipid profiles of ovarian cancer tissue samples. Twenty-three frozen ovarian cancer samples and 6 adjacent normal samples were analyzed using histology-directed, matrix-assisted laser desorption/ionization mass spectrometry. Sinapinic acid and 2, 5-dihydroxybenzoic acid/&agr;-cyano-4-hydroxycinnamic acid were manually deposited on areas of each tissue section enriched in epithelial cells to identify protein and lipid profiles respectively, and mass spectra were acquired using a matrix-assisted laser desorption/ionization–time of flight instrument. Protein and lipid profiles classify 11 cancer and 3 adjacent normal samples in 100 random test sets with 92.9% median accuracy. Phosphatidylcholines {32:3} [M + Na]+ (m/z = 750.66), {34:1} [M + K]+ (m/z = 798.60), and {36:2} [M + K]+ (m/z = 824.56) were found to be increased in ovarian cancer. Interestingly, breast cancer–associated changes in lipid and protein profiles were also found in ovarian cancer. Thus, protein and lipid profiles accurately distinguish ovarian cancer from adjacent normal tissue samples. Common cancer-associated alterations in lipid and protein profiles were identified between ovarian and breast cancers.
Predicting benefits of spawning-habitat rehabilitation to salmonid (Oncorhynchus spp.) fry production in a regulated California river

Joseph E. Merz, Jose D. Setka, Gregory B. Pasternack, and Joseph M. Wheaton Abstract: We tested the hypothesis that spawning-bed enhancement increases survival and growth of chinook salmon (Oncorhynchus tshawytscha) embryos in a regulated California stream with a gravel deficit. We also examined how 12 physical parameters correlated within spawning sites and how well they predicted survival and growth of chinook salmon and steelhead (Oncorhynchus mykiss) embryos. Salmon embryos planted in enhanced gravels had higher rates of survival to the swim-up stage than embryos planted in unenhanced spawning gravels. No significant increase in growth was observed. Intergravel temperature and substrate size were strongly correlated with distance downstream from the lowest nonpassable dam. Intergravel turbidity and total suspended and volatile solids were also strongly correlated. Multiple-regression models were built with a combination of physical measurements to predict survival and length of salmon and steelhead embryos. Survival models accounted for 87% of the variation around the mean for salmon and 82% for steelhead. Growth models accounted for 95% of the variation around the mean for salmon and 89% for steelhead. These findings suggest that spawning-bed enhancement can improve embryo survival in degraded habitat. Additionally, measurements of a suite of physical parameters before and after spawning-bed manipulation can accurately predict benefits to target species.
Wire grid metamaterial for directive emission

In this work are reported the electromagnetic properties of an arrangement of periodic metallic grids devised to provide in the 12.5-20.0 GHz frequency range a refractive index less than unity with view to enhance the functionalities of a Ku-band horn antennas. The ultra-refractive behavior of the metamaterial structure is demonstrated by the impedance and refractive index values retrieved from simulated scattering parameters.
A Conflicting Relationship Between Online Product Page Viewing And Product Returns

Costly product returns have become a significant problem for most online retailers. In this study, we investigate the conflicting relationship between online product page viewing and product returns. Based on expectation disconfirmation theory, we explain two counteracting effects of product page viewing on product returns, and propose that more product page viewing leads to higher likelihood of product returns. Moreover, we examine the role of three IT systems, namely product recommendation systems, product visualization systems and consumer review systems, in attenuating the effect of product page viewing on product returns. By using a unique clickstream dataset, we employ a fixed effect logit model to test the research hypotheses. Our study has the potential to contribute to the extant literature by unveiling how consumers’ pre-purchase behaviors influence their return behaviors. Practitioners can also benefit from this research in deciding how to economically invest in IT systems to reduce product return rates.
Knowledge of God in Philo of Alexandria with special reference to the Allegorical Commentary

This thesis is a context-sensitive study of key epistemological commitments and concerns presented in Philo’s two series of exegetical writings. The major conclusion advanced in this thesis is that two theological epistemologies, distinct yet related, can be detected among these writings. The first epistemology is specific to the Allegorical Commentary. The second epistemology is specific to the ‘Exposition of the Law. ’ The epistemology of the Allegorical Commentary reflects a threefold conviction: the sovereignty of God, the creaturely contingency of the human mind and its inescapable limitations. In conversation with key epistemological notions of his day, Philo develops this threefold conviction in exegetical discourses that are grounded in Pentateuchal texts portraying the God of Moses as both possessing epistemic authority and aiding the aspiring mind to gain purification and perfection in the knowledge of God. Guided by this threefold conviction, Philo enlists key metaphors of his day – initiation into divine mysteries and divine inspiration, among others –in order to capture something of the essence of Moses’ twofold way of ascending to the divine, an approach which requires at times the enhancement of human reason and at other times the eviction of human reason. The epistemology of the ‘Exposition’ reflects Philo’s understanding of the Pentateuch as a perfect whole partitioned into three distinct yet inseverable parts. Philo’s knowledge discourses in the ‘creation’ part of the ‘Exposition’ reflect two primary movements of thought. The first is heavily invested with a Platonic reading of Genesis 1.27 while the second invests Genesis 2.7 with a mixture of Platonic and Stoic notions of human transformation and well-being. Philo’s discourses in the ‘patriarchs’ segment reflect an interest in portraying the three great patriarchs as exemplars of the virtues of instruction (Abraham), nature (Isaac), and practice (Jacob) which featured prominently in Greek models of education. In the ‘Moses’ segment of the ‘Exposition,’ many of Philo’s discourses on knowledge are marked by an interest in presenting Moses as the ideal king, lawgiver, prophet and priest who surpasses Plato’s paradigm of the philosopher-king. In keeping with this view, Philo insists that the written laws of Moses represent the perfect counterpart to the unwritten law of nature. The life and laws of Moses serve as the paradigm for Philo to understand his own experiences of noetic ascent and exhort readers to cultivate similar aspirational notions and practices.