Miracle-dz/UniFAR-FTUs huggingface dataset:
Pengaruh Pendapatan Asli Daerah terhadap Pertumbuhan Ekonomi dengan Belanja Modal dan Investasi Swasta sebagai Pemoderasi

Pertumbuhan Ekonomi merupakan salah satu indikator untuk mengukur keberhasilan pembangunan ekonomi dalam suatu negara. Diharapkan dengan adanya penerimaan dari Pendapatan Asli Daerah (PAD) dapat meningkatkan Pertumbuhan Ekonomi daerah, peningkatan PAD dapat meningkatkan investasi Belanja Modal pemerintah daerah, pemerintah daerah perlu memberikan perhatian khusus dalam bidang investasi swasta. Penelitian ini adalah untuk mengetahui pengaruh pendapatan asli daerah terhadap pertumbuhan ekonomi dengan belanja modal dan investasi swasta sebagai variabel pemoderasi. Dilakukan pada 8 Kabupaten dan 1 Kota Madya di Provinsi Bali pada tahun 2012-2016. Teknik analisis yang digunakan pada penelitian ini yaitu dengan menggunakan teknik Moderated Regression Analysis (MRA) dengan menggunakan program Statistical Product and Service Solution (SPSS). Hasil penelitian ini menunjukkan PAD berpengaruh positif terhadap pertumbuhan ekonomi. Belanja Modal memperlemah pengaruh PAD terhadap Pertumbuhan Ekonomi, sedangkan Investasi Swasta memperkuat pengaruh PAD terhadap Pertumbuhan Ekonomi. Kata kunci: pendapatan asli daerah, pertumbuhan ekonomi, belanja modal, investasi swasta.
Exploring forward-looking information in integrated reporting: A multi-dimensional analysis

Purpose The purpose of this paper is to investigate the effect of firm characteristics on forward-looking disclosure (forward-looking information (FLI)) within the context of integrated reporting (IR). The study assesses the extent of FLI provided in integrated reports and empirically fills the research gap into the topics of FLI disclosed in the IR. Design/methodology/approach A manual content analysis is run to investigate the level and the topics of FLI in 282 integrated reports available in the International Integrated Reporting Council (IIRC) website. A disclosure index composition consisting of 27 information items is developed from the list of content elements comprised in the Integrated Reporting Framework (IIRC, 2013). Three hypotheses are proposed and eight models are tested within a multivariate regression analysis in order to explore the effects of three main variables (firm size, profitability and leverage) on FLI. Findings The study confirms that firms are reluctant to provide FLI in integrated reports. The results show that profitability and firm size have a statistically significant relationship with the level of specific topics of FLI. Conversely, leverage is found to be insignificant in explaining the extent of FLI. Research limitations/implications To improve the reliability of findings presented in this study, several others may be conducted by inspecting more variables that may affect the extent of FLI or by increasing the number of companies included in the sample. Practical implications The results provide comprehensive insights into the current forward-looking disclosure practices of early adopters in integrated reports and can be a useful evidence for preparers of it. This paper has also practical implications especially for managers and regulators (e.g. IIRC) since it encourages further efforts to promote FLI if firms want that the disclosure offered in the IR is perceived as “informative” by their significant stakeholders. Originality/value The research adds to the prior disclosure literature concerning FLI since acquired results are ambiguous. There are a very restricted number of studies that have explained the variation of FLI in the light of firm characteristics and no study has analyzed this research topic within the context of IR.
Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei Published, JLR Papers in Press, November 26, 2006.

Trypanosoma brucei (TB) cultured in rat blood, bovine serum, or lipid-depleted serum generated distinct differences in cholesterol availability. Whereas cell proliferation of the parasite was relatively unaffected by cholesterol availability, the ratios of cellular ergostenols to cholesterol varied from close to unity to 3 orders of magnitude different with cholesterol as the major sterol (>99%) of bloodstream form cells. In the procyclic form cultured with lipid-depleted serum, 15 sterols at 52 fg/cell were identified by GC-MS. The structures of these sterols reveal a nonconventional ergosterol pathway consistent with the novel product diversity catalyzed by the recently cloned sterol methyltransferase (SMT). A potent transition state analog of the TB SMT C24 alkylation reaction, 25-azalanosterol (25-AL; inhibition constant Ki = 39 nM), was found to inhibit the growth of the procyclic and bloodstream forms at an IC50 of ∼1 μM. This previously unrecognized catalyst-specific inhibition of cell growth was unmasked further using the 25-AL-treated procyclic form, which, compared with control cultures, caused a change in cellular sterol content from ergostenols to cholesterol. However, growth of the bloodstream form disrupted by 25-AL was not rescued by cholesterol absorption from the host, suggesting an essential role for ergosterol (24-methyl sterol) in cell proliferation and that the SMT can be a new enzyme target for drug design.
Spatiotemporal Modeling for Crowd Counting in Videos

Region of Interest (ROI) crowd counting can be formulated as a regression problem of learning a mapping from an image or a video frame to a crowd density map. Recently, convolutional neural network (CNN) models have achieved promising results for crowd counting. However, even when dealing with video data, CNN-based methods still consider each video frame independently, ignoring the strong temporal correlation between neighboring frames. To exploit the otherwise very useful temporal information in video sequences, we propose a variant of a recent deep learning model called convolutional LSTM (ConvLSTM) for crowd counting. Unlike the previous CNN-based methods, our method fully captures both spatial and temporal dependencies. Furthermore, we extend the ConvLSTM model to a bidirectional ConvLSTM model which can access long-range information in both directions. Extensive experiments using four publicly available datasets demonstrate the reliability of our approach and the effectiveness of incorporating temporal information to boost the accuracy of crowd counting. In addition, we also conduct some transfer learning experiments to show that once our model is trained on one dataset, its learning experience can be transferred easily to a new dataset which consists of only very few video frames for model adaptation.
A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures.

The objectives of the present study were: (1) to develop a risk assessment methodology for chemical mixtures that accounts for pharmacokinetic interactions among components, and (2) to apply this methodology to assess the health risk associated with occupational inhalation exposure to airborne mixtures of dichloromethane, benzene, toluene, ethylbenzene, and m-xylene. The basis of the proposed risk assessment methodology relates to the characterization of the change in tissue dose metrics (e.g., area under the concentration-time curve for parent chemical in tissues [AUCtissue], maximal concentration of parent chemical or metabolite [Cmax], quantity metabolized over a period of time) in humans, during mixed exposures using PBPK models. For systemic toxicants, an interaction-based hazard index was calculated using data on tissue dose of mixture constituents. Initially, the AUCtarget tissue (AUCtt) corresponding to guideline values (e.g., threshold limit value [TLV]) of individual chemicals were obtained. Then, the AUCtt for each chemical during mixed exposure was obtained using a mixture PBPK model that accounted for the binary and higher order interactions occurring within the mixture. An interaction-based hazard index was then calculated for each toxic effect by summing the ratio of AUCtt obtained during mixed exposure (predefined mixture) and single exposure (TLV). For the carcinogenic constituents of the mixture, an interaction-based response additivity approach was applied. This method consisted of adding the cancer risk for each constituent, calculated as the product of q*tissue dose and AUCtt. The AUCtt during mixture exposures was obtained using an interaction-based PBPK model. The approaches developed in the present study permit, for the first time, the consideration of the impact of multichemical pharmacokinetic interactions at a quantitative level in mixture risk assessments.
[The first effect of the national vaccination campaign against meningococcal-C disease: a rapid and sharp decrease in the number of patients].

OBJECTIVE To describe the initial effects of the large-scale vaccination campaign in June-July of 2002 (1-5- and 15-18-year-olds) and September-November of 2002 (6-14-year-olds) on the incidence of group-C meningococcal disease in the Netherlands. DESIGN Descriptive. METHOD The incidence of meningococcal disease and the serogroup distribution were determined on the basis of the patient data associated with isolates of Neisseria meningitidis that were sent to the Netherlands Reference Laboratory for Bacterial Meningitis during the period from 1 January 1999 to 31 January 2003. RESULTS The highest monthly incidence of serogroup-C disease was reported in January-April 2002 (2.2-3.1/100,000), after which the incidence remained more or less unchanged after September at a level of 0.1-0.4/100,000. The incidence of meningococcal-C disease was 73% lower in August-October 2002 compared with the same period in 2001. In the same months, the incidence of meningococcal-C disease for the 0, 1-5, 6-14, 15-18 and > 18 year-olds was 49%, 80%, 89%, 89% and 42%, respectively, lower than in the same months in the previous year. The percentage of meningococcal disease caused by serogroup-C fluctuated from 35 to 49% in January-August 2002 and decreased to 9-19% in September-December 2002. There was also a decrease in the unvaccinated age groups. CONCLUSION The vaccination campaign led almost immediately to a sharp decrease in the number of patients with meningococcal serogroup-C disease.
Analysis on the Threshold Effect of the Factors Affecting the Relationship between China's Economic Growth and Carbon Emission

China's rapid economic growth has brought many environmental problems, and the rapid growth of carbon emission attracts more and more people's attention, so the research on the relationship between economic growth and carbon dioxide emission is increasingly important. Based on the threshold panel model developed by Hansen, this paper chooses the provincial panel data from 1995 to 2014 and analyzes the influence of energy intensity, environmental regulation and the introduction of foreign capital on the relationship between economic growth and carbon emission. The results show that there is a significant nonlinear relationship between them, there is double threshold of energy intensity, single threshold of environmental regulation, and there is no threshold for foreign capital introduction. Through the results of the factors’ threshold effect, then we give some reasonable suggestions. Keywords—economic growth; carbon emission; threshold effect; panel
Regional distribution and location choices of immigrants in Germany

ABSTRACT This paper investigates initial and subsequent location choices of recent European Union immigrants in Germany at the county level (NUTS-3). Using federal employment register data, the evidence suggests heterogeneous preferences among individuals regarding regional characteristics. For the first location choice, good labour market conditions seem to attract immigrants strongly, while the presence of co-nationals appears to be less important. However, regarding subsequent location choices, ethnic concentration apparently increases its impact on regional attractiveness. The primary conclusion of this paper is that assimilation in the sense of a more equal distribution of immigrants across regions seems to fail.
Anchor Loss Variation in MEMS Wine-Glass Mode Disk Resonators Due to Fluctuating Fabrication Process

With increasing demand for high-frequency, high-quality factor (Q-factor) mechanical resonators, the Q-factor declining issue at high-frequency becomes increasingly prominent. This paper studies the performance variations of disk resonators under the wine-glass vibration mode due to the support beam offset that are caused by process deviations. The formula of the Q-factor in terms of the support loss is derived to further illustrate the change of the Q-factor caused by the beam offset. It is found that the impact of the extensional mode on the performance is more serious than that of the flexural mode, since the extensional mode may destruct the mode shape and decrease the radial size (i.e., amplitude) of the disk. Finally, some design methods on how to improve the Q-factor of the resonator are given. The numerical results show that there are, respectively, 0.07% and 13.7% increase in the resonant frequency and the disk radial size when the support beam offset is 4°, whereas the increase in the resonant frequency and the disk radial size becomes 0.96% and 69.8%, respectively, when the support beam offset reaches 16°. For the Q-factor, although the flexural-mode Q-factor, Qf, increases with increasing support beam offset, the overall Q-factor of the resonator still decreases due to the dominant extensional-mode loss. In the worst case, the largest decline reaches 27.11% from the zero offset position (where there is only flexural-mode loss) to the 16° offset position.
Dermatophyte Identification Using Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry

ABSTRACT The performance of the Bruker Biotyper matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometer (MS) for the identification of dermatophytes from clinical cultures was compared to that of dermatophyte identification using 28S rRNA gene sequencing. The MALDI Biotyper library (MBL; version 3.0) was used alone and in combination with a supplemented library containing an additional 20 dermatophyte spectra (S-MBL). Acquired spectra were interpreted using both the manufacturer-recommended scores (genus, ≥1.7; species, ≥2.0) and adjusted cutoff values established by this study (genus, ≥1.5; species, ≥1.7); identifications required a minimum 10% difference in scores between the top two different organisms to be considered correct. One hundred well-characterized, archived dermatophyte isolates and 71 fresh dermatophyte cultures were evaluated using both libraries and both sets of cutoff criteria. Collectively, the S-MBL significantly outperformed the MBL at both the genus (93% versus 37.4%; P < 0,0001) and species (59.6% versus 20.5%; P < 0.0001) levels when using the adjusted score criteria. Importantly, application of the lowered cutoff values significantly improved genus (P = 0.005)- and species (P < 0.0001)-level identification for the S-MBL, without leading to an increase in misidentifications. MALDI-TOF MS is a cost-effective and rapid alternative to traditional or molecular methods for dermatophyte identification, provided that the reference library is supplemented to sufficiently encompass clinically relevant, intraspecies strain diversity.
Spontaneous cleavage of RNA in ternary complexes of Escherichia coli RNA polymerase and its significance for the mechanism of transcription.

Ternary complexes of RNA polymerase, bearing the nascent RNA transcript, are intermediates in the synthesis of all RNAs and are regulatory targets of factors that control RNA chain elongation and termination. To study the catalytic and regulatory properties of RNA polymerases during elongation, we have developed methods for the preparation of these intermediates halted at defined positions along a DNA template. To our surprise, some of these halted complexes undergo a reaction in which the RNA transcript is cleaved up to 10 nucleotides from its 3'-terminal growing point. The 5'-terminal fragment, bearing a free 3'-OH residue, remains bound to the RNA polymerase-DNA complex and can resume elongation, whereas the 3'-terminal oligonucleotide of 2-10 nucleotides, bearing a 5'-phosphate, is released. RNA cleavage occurs only in the ternary complex and requires a divalent metal ion such as Mg2+. Since RNA polymerases are believed to have a single catalytic site for nucleotide addition, this reaction is unlikely to be due to hydrolysis catalyzed by this site comparable to the 3'----5' exonuclease activity associated with the catalytic center found for some DNA polymerases. Nor is this reaction easily explained by models for transcription elongation that postulate a 12-base-pair DNA.RNA hybrid as intermediate. Instead, we suggest that this is an unusual kind of protein-facilitated reaction in which tight binding of the RNA product to the enzyme strains the RNA phosphodiester linkage, resulting in cleavage of the RNA well away from the catalytic center. By this model, the nascent RNA enters a product binding site beginning 3 or 4 nucleotides from the growing point at the 3' terminus. This RNA binding site extends for up to 16 nucleotides along the protein surface. The stress brought about by this binding appears to vary considerably for different ternary complexes and may play a role in driving the translocation of the RNA polymerase along the DNA.
Perceived causality influences brain activity evoked by biological motion

Abstract Using functional magnetic resonance imaging (fMRI), we investigated brain activity in an observer who watched the hand and arm motions of an individual when that individual was, or was not, the cause of the motion. Subjects viewed a realistic animated 3D character who sat at a table containing four pistons. On Intended Motion trials, the character raised his hand and arm upwards. On Unintended Motion trials, the piston under one of the character's hands pushed the hand and arm upward with the same motion. Finally, during Non-Biological Motion control trials, a piston pushed a coffee mug upward in the same smooth motion. Hand and arm motions, regardless of intention, evoked significantly more activity than control trials in a bilateral region that extended ventrally from the posterior superior temporal sulcus (pSTS) region and which was more spatially extensive in the right hemisphere. The left pSTS near the temporal-parietal junction, robustly differentiated between the Intended Motion and Unintended Motion conditions. Here, strong activity was observed for Intended Motion trials, while Unintended Motion trials evoked similar activity as the coffee mug trials. Our results demonstrate a strong hemispheric bias in the role of the pSTS in the perception of causality of biological motion.
Aerobic exercise for women during pregnancy.

BACKGROUND Physiological responses of the fetus (especially increase in heart rate) to single, brief bouts of maternal exercise have been documented frequently, suggesting that maternal exercise might have beneficial or adverse effects on pregnancy outcome. OBJECTIVES The objective of this review was to assess the effects of advising healthy pregnant women to engage in regular (at least two to three times per week) aerobic exercise on physical fitness, labour and delivery, and the outcome of pregnancy. SEARCH STRATEGY The Cochrane Pregnancy and Childbirth Group trials register was searched and researchers in the field were contacted. Date of last search: January 2002. SELECTION CRITERIA Acceptably controlled comparisons of prescribed aerobic exercise programmes. DATA COLLECTION AND ANALYSIS One reviewer assessed trial quality and extracted data. Study authors were contacted for additional information. MAIN RESULTS Ten trials involving 688 women were included. The trials were not of high methodologic quality. Five trials reported significant improvement in physical fitness in the exercise group, although differences in measures used to assess fitness prevent a quantitative pooling of results. Six trials reported on pregnancy outcomes. A statistically significant increased risk of preterm birth (relative risk (RR) = 2.29 [95% confidence interval 1.02 to 5.13]) in the exercise group is inconsistent with the absence of effect on mean gestational age [+0.0 (-0.4 to +0.4) weeks] and may have been biased by post-randomization exclusion of women with preterm labor. Results bearing on fetal growth (birth weight, length, and head circumference) were highly variable. One trial found improvements among exercising women in several aspects of self-reported body image, including muscle strength, energy level, and body build. REVIEWER'S CONCLUSIONS Regular aerobic exercise during pregnancy appears to improve (or maintain) physical fitness and body image. Available data are insufficient to infer important risks or benefits for the mother or infant.
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors

The myocyte enhancer-binding factor 2 (MEF2) site is an essential element of many muscle-specific enhancers and promoters that binds nuclear proteins from muscle and brain. Recently, we have cloned a family of MEF2 transcription factors produced by two genes that, at the mRNA level, are broadly expressed and produce tissue-specific isoforms by posttranscriptional processes (Y.-T. Yu, R. E. Breitbart, L. B. Smoot, Y. Lee, V. Mahdavi, and B. Nadal-Ginard, Genes Dev. 6:1783-1798, 1992). Here, we report the isolation and functional characterization of cDNA clones encoding four MEF2 factors derived from a separate gene that we have named hMEF2C. In contrast to those of the previously reported genes, the transcripts of the hMEF2C gene are restricted to skeletal muscle and brain. One of the alternate exons is exclusively present in brain transcripts. The products of this gene have DNA-binding and trans-activating activities indistinguishable from those of the previously reported MEF2 factors. The hMEF2C gene is induced late during myogenic differentiation, and its expression is limited to a subset of cortical neurons. The potential targets for this transcription factor in a subset of neurons are not known at this time. The strict tissue-specific pattern of expression of hMEF2C in comparison with the more ubiquitous expression of other MEF2 genes suggests a different mode of regulation and a potentially important role of hMEF2C factors in myogenesis and neurogenesis.
Cutaneous changes in internal malignancy: Study from a tertiary care center

Background: A wide variety of systemic diseases and internal malignancies have cutaneous manifestations. In the context of internal malignancy, many cutaneous changes are highly specific to the underlying malignancy, while other changes are nonspecific. Some changes are also due to the modalities employed in the treatment of malignancies. Methods: Two hundred and fifty patients who were diagnosed with internal malignancy and who were attending the department of radiation oncology, were evaluated at the Department of Dermatology, Sexually Transmitted Diseases and Leprosy of Government Medical College, Srinagar. The study was conducted over a period of 5 months. Relevant investigations, wherever needed, were carried out. Results: Among the 250 cases examined, nonspecific cutaneous changes were seen in 39 (15.6%) cases, whereas specific skin lesions in the form of cutaneous metastases were seen in two (0.8%) patients. Nail changes and hair changes were also seen in some patients. Limitations: As this was a cross-sectional study and most of the patients were lost to follow up, we could not assess the outcome of the dermatological changes seen in the affected patients. Conclusion: Many dermatological changes are noticed early in the course of malignancy, reflecting a strong association of the cutaneous change with malignancy. Few manifestations occur late in the course of the disease, indicating dissemination or immunosuppression. Some changes reflect radiation-induced or chemotherapy-induced toxicity, indicating the need for treatment modifications.