Miracle-dz/UniFAR-FTUs huggingface dataset:
Sickness absence diagnoses among abstainers, low‐risk drinkers and at‐risk drinkers: consideration of the U‐shaped association between alcohol use and sickness absence in four cohort studies

Abstract Aims To estimate differences in the strength and shape of associations between alcohol use and diagnosis‐specific sickness absence. Design A multi‐cohort study. Participants (n = 47 520) responded to a survey on alcohol use at two time‐points, and were linked to records of sickness absence. Diagnosis‐specific sickness absence was followed for 4–7 years from the latter survey. Setting and participants From Finland, we had population cohort survey data from 1998 and 2003 and employee cohort survey data from 2000–02 and 2004. From France and the United Kingdom, we had employee cohort survey data from 1993 and 1997, and 1985–88 and 1991–94, respectively. Measurements We used standard questionnaires to assess alcohol intake categorized into 0, 1–11 and > 11 units per week in women and 0, 1–34 and > 34 units per week in men. We identified groups with stable and changing alcohol use over time. We linked participants to records from sickness absence registers. Diagnoses of sickness absence were coded according to the International Classification of Diseases. Estimates were adjusted for sex, age, socio‐economic status, smoking and body mass index. Findings Women who reported drinking 1–11 units and men who reported drinking 1–34 units of alcohol per week in both surveys were the reference group. Compared with them, women and men who reported no alcohol use in either survey had a higher risk of sickness absence due to mental disorders [rate ratio = 1.51, 95% confidence interval (CI) = 1.22–1.88], musculoskeletal disorders (1.22, 95% CI = 1.06–1.41), diseases of the digestive system (1.35, 95% CI = 1.02–1.77) and diseases of the respiratory system (1.49, 95% CI = 1.29–1.72). Women who reported alcohol consumption of > 11 weekly units and men who reported alcohol consumption of > 34 units per week in both surveys were at increased risk of absence due to injury or poisoning (1.44, 95% CI = 1.13–1.83). Conclusions In Finland, France and the United Kingdom, people who report not drinking any alcohol on two occasions several years apart appear to have a higher prevalence of sickness absence from work with chronic somatic and mental illness diagnoses than those drinking below a risk threshold of 11 units per week for women and 34 units per week for men. Persistent at‐risk drinking in Finland, France and the United Kingdom appears to be related to increased absence due to injury or poisoning.
Significance of Serum Nitric Oxide and Superoxide Dismutase in Oral Submucous Fibrosis and Squamous Cell Carcinoma: A Comparative Study

Introduction: This study aimed at comparative analysis of serum nitric oxide (NO) and superoxide dismutase (SOD) levels as therapeutic and prognostic biomarkers in patients with oral submucous fibrosis (OSMF) and squamous cell carcinoma (SCC). Materials and Methods: Eighty-seven patients were grouped into Group I (n = 29, OSMF), Group II (n = 29, oral SCC), and Group III (n = 29, controls). Two ml of venous blood was collected from patients after overnight fast to avoid any dietary influence on the serum beta-carotene. Standard protocols were followed in transfer, storage, and processing of blood. Modified copper-cadmium reduction method for rapid assay to estimate the serum NO and EnzychromTM SOD assay kit to determine SOD levels were used. Results: The mean level of NO level in Group I, Group II, and Group III was 42.49, 50.08, and 32.81, respectively, and mean level of SOD in Group I, Group II, and Group III were 207.65, 196.93, and 226.57, respectively. The P values were calculated and were statistically significant (<0.001). Conclusion: An increase in level of oxidant NO in OSMF followed by SCC and decrease in level of antioxidant SOD in OSMF followed by SCC were noted. These levels of NO and antioxidant SOD can be used as prognostic and therapeutic biomarkers.
Skilful seasonal forecasts of streamflow over Europe

Abstract. This paper considers whether there is any added value in using seasonal climate forecasts instead of historical meteorological observations for forecasting streamflow on seasonal timescales over Europe. A Europe-wide analysis of the skill of the newly operational EFAS (European Flood Awareness System) seasonal streamflow forecasts (produced by forcing the Lisflood model with the ECMWF System 4 seasonal climate forecasts), benchmarked against the ensemble streamflow prediction (ESP) forecasting approach (produced by forcing the Lisflood model with historical meteorological observations), is undertaken. The results suggest that, on average, the System 4 seasonal climate forecasts improve the streamflow predictability over historical meteorological observations for the first month of lead time only (in terms of hindcast accuracy, sharpness and overall performance). However, the predictability varies in space and time and is greater in winter and autumn. Parts of Europe additionally exhibit a longer predictability, up to 7 months of lead time, for certain months within a season. In terms of hindcast reliability, the EFAS seasonal streamflow hindcasts are on average less skilful than the ESP for all lead times. The results also highlight the potential usefulness of the EFAS seasonal streamflow forecasts for decision-making (measured in terms of the hindcast discrimination for the lower and upper terciles of the simulated streamflow). Although the ESP is the most potentially useful forecasting approach in Europe, the EFAS seasonal streamflow forecasts appear more potentially useful than the ESP in some regions and for certain seasons, especially in winter for almost 40 % of Europe. Patterns in the EFAS seasonal streamflow hindcast skill are however not mirrored in the System 4 seasonal climate hindcasts, hinting at the need for a better understanding of the link between hydrological and meteorological variables on seasonal timescales, with the aim of improving climate-model-based seasonal streamflow forecasting.
Towards Semi-Virtual Design Thinking - Creativity in Dispersed Multicultural and Multidisciplinary Innovation Project Teams

This paper aims at examining whether the innovation approach Design Thinking (DT), which is usually performed in an analogue setting, can also be performed in a semi-virtual setting. We conducted an experiment comparing a fully analogue to a semivirtual DT workshop with overall 59 participants from 27 different countries and 11 different disciplines separated into an experimentaland control group. For the evaluation, we composed items from the psychological construct of Shared Mental Models (SMM) and discussed existing Media Theories in order to draw conclusions on the impact of performing DT semi-virtually in regard to using a digital whiteboard. Against our expectations and assumptions from theory, we reveal that a semi-virtual DT workshop can lead to high levels of shared understanding, satisfaction and perceived effectiveness. We argue that the applied digital whiteboard supports a creative semi-virtual collaboration due to its advanced functionalities, which supports the Media Richness Theory.
"They are like personalized mini-Googles": Seeking Information on Facebook Groups

Our study reports on everyday life information search (ELIS) practice using Facebook Groups. While previous research has examined social Q&A in the context of status message question asking (SMQA) on Facebook and Twitter, we discuss how people step outside their personal networks to find answers to questions while staying within the Facebook environment. We investigate two popular Q&A Facebook Groups in the city of Bangalore, India and ask why people turn to Facebook Groups for the information needs, the nature of costs of using these groups for information search, and how Groups are groomed to host social Q&A practices. Our findings suggest that Facebook Groups can be popular venues for information search because of its structural features as well as the networked sociality that it engenders.
Learning Analytics in Medical Education Assessment: The Past, the Present, and the Future

With the implementation of competency‐based medical education (CBME) in emergency medicine, residency programs will amass substantial amounts of qualitative and quantitative data about trainees’ performances. This increased volume of data will challenge traditional processes for assessing trainees and remediating training deficiencies. At the intersection of trainee performance data and statistical modeling lies the field of medical learning analytics. At a local training program level, learning analytics has the potential to assist program directors and competency committees with interpreting assessment data to inform decision making. On a broader level, learning analytics can be used to explore system questions and identify problems that may impact our educational programs. Scholars outside of health professions education have been exploring the use of learning analytics for years and their theories and applications have the potential to inform our implementation of CBME. The purpose of this review is to characterize the methodologies of learning analytics and explore their potential to guide new forms of assessment within medical education.
The renaissance of Gallager's low-density parity-check codes

LDPC codes were invented in 1960 by R. Gallager. They were largely ignored until the discovery of turbo codes in 1993. Since then, LDPC codes have experienced a renaissance and are now one of the most intensely studied areas in coding. In this article we review the basic structure of LDPC codes and the iterative algorithms that are used to decode them. We also briefly consider the state of the art of LDPC design.
The Three Pillars of Virtual Reality? Investigating the Roles of Immersion, Presence, and Interactivity

Virtual reality (VR) technologies enable a new media consumption experience. Although VR’s origins trace back at least to the 1960s, it is still unclear how VR’s postulated key features immersion, presence, and interactivity contribute to that experience. Furthermore, it is unclear whether flow as a construct closely related to immersion offers explanatory power in investigating VR. On the basis of a quantitative survey in a VR center with 294 participants, I analyze the interplay of the key features and exemplify their influence in a VR context by relating them to satisfaction with the VR experience. Using a flow-based conceptualization of immersion, I find that presence as well as interactivity contribute to immersion. In addition, interactivity contributes to presence. Furthermore, my results show that immersion influences satisfaction with a VR experience, indicating that a flow-based conceptualization of immersion is a suitable predictor in VR contexts.
Superficial temporal artery-middle cerebral artery bypass for the treatment of complex middle cerebral artery aneurysms

Objectives: Direct microsurgical clipping for complex middle cerebral artery (MCA) aneurysms may require a long ischemic time. Sacrifice of the parent artery with trapping or endovascular coiling also may lead to ischemic stroke. We described our institutional experience with the treatment of complex MCA aneurysms using extracranial-intracranial (EC-IC) (superficial temporal artery [STA]-MCA) bypass. Materials and Methods: We retrospectively reviewed patients who had treatment of IC aneurysms with the assistance of STA-MCA bypass from July 2002 to December 2016. Six patients with complex MCA aneurysms were identified, and we reviewed their clinical characteristics. Results: There were three men and three women with age ranging from 27 to 59 (mean 49) years old. Image studies showed subarachnoid hemorrhage in three cases. All patients underwent STA-MCA anastomosis, and the follow-up period ranged from 2 to 116 months (mean 51.5 months). Two of the six MCA aneurysms were fusiform, two aneurysms had bizarre configurations, one was a dissecting saccular aneurysm, and one had a blister configuration. Three patients received direct vessel trapping, two patients received aneurysm clipping, and one received aneurysm coiling. The postoperative bypass patency rate was 100%. The modified Rankin scale showed good outcomes in the six patients. Conclusions: EC-IC bypass plays an important role as a salvage procedure in the treatment of complex MCA aneurysms which have a fusiform, bizarre, or blister configuration.
The DoloTest® in a specialized headache center among patients receiving psychological treatment. A pilot study

Abstract Background The DoloTest is a newer health-related quality of life (HRQoL) monitoring instrument for pain, not yet validated for headache. Aims To examine the usefulness of the DoloTest in a specialized headache center. Methods The sample consisted of patients referred to psychologists from the Danish Headache Center (DHC) for whom the test was carried out at start of, end of, and 6 months after treatment. Points on eight scales of the test were measured (values ranged from 0 to 100), then totaled (0 to 800). Scores were analyzed using Wilcoxon Signed Ranks test. The correlation between headache days and DoloTest scores were computed using linear regression adjusted for age. Qualitative feedback on usefulness of the test were gathered from psychologists. Results Of 135 patients included, 105 completed treatment. On average, headache days decreased from 22 days per month at start of treatment (SD 9.0, median 29) to 18 days at end of treatment (SD 10.8, median 19) (p<0.001). At end of treatment, DoloTest scores improved for pain (p=0.015) and reduced energy and strength (p=0.034). At 6 months’ follow-up, total scores improved (p=0.034), as well as component scores for pain (p=0.010), problems with strenuous activity (p=0.045) and reduced energy and strength (p=0.012). Correlation between reduced headache days and improved DoloTest scores was 0.303 (p=0.028). Psychologists found the test useful in monitoring and evaluating patients. Conclusions The DoloTest was useful for psychoeducation and for monitoring the effect of headache treatment. Implications The DoloTest is a potential HRQoL monitoring instrument for headache patients. We recommend further validation studies.
Secrecy Outage Analysis of Mixed RF-FSO Downlink SWIPT Systems

We analyze a secure dual-hop mixed radio frequency-free space optical (RF-FSO) downlink simultaneous wireless information and power transfer system. The FSO link and all RF links experience Gamma–Gamma, independent, and identical Nakagami- $m$ fading, respectively. We analyze the effects of atmospheric turbulence, pointing error, detection technology, path loss, and energy harvesting on secrecy performance. Signal-to-noise ratios at both the legitimate and illegitimate receivers are not independent since they are both simultaneously influenced by the FSO link. We derive the closed-form expression of the secrecy outage probability (SOP) as well as the asymptotic result for SOP when signal-to-noise ratios at relay and legitimate destinations tend to infinity. Monte-Carlo simulations are performed to verify the accuracy of our analysis. The results show that the secrecy diversity order (SDO) depends on the fading parameter of the relay-destination link and the number of the destination’s antennas. In addition, the SDO also depends on the fading parameters, the pointing error parameter, and the detection type of the FSO link.
Theta Phase Synchronization between the Human Hippocampus and Prefrontal Cortex Increases during Encoding of Unexpected Information: A Case Study

Events that violate predictions are thought to not only modulate activity within the hippocampus and PFC but also enhance communication between the two regions. Scalp and intracranial EEG studies have shown that oscillations in the theta frequency band are enhanced during processing of contextually unexpected information. Some theories suggest that the hippocampus and PFC interact during processing of unexpected events, and it is possible that theta oscillations may mediate these interactions. Here, we had the rare opportunity to conduct simultaneous electrophysiological recordings from the human hippocampus and PFC from two patients undergoing presurgical evaluation for pharmacoresistant epilepsy. Recordings were conducted during a task that involved encoding of contextually expected and unexpected visual stimuli. Across both patients, hippocampal–prefrontal theta phase synchronization was significantly higher during encoding of contextually unexpected study items, relative to contextually expected study items. Furthermore, the hippocampal–prefrontal theta phase synchronization was larger for contextually unexpected items that were later remembered compared with later forgotten items. Moreover, we did not find increased theta synchronization between the PFC and rhinal cortex, suggesting that the observed effects were specific to prefrontal–hippocampal interactions. Our findings are consistent with the idea that theta oscillations orchestrate communication between the hippocampus and PFC in support of enhanced encoding of contextually deviant information.
Feeling How Old I Am: Subjective Age Is Associated With Estimated Brain Age

While the aging process is a universal phenomenon, people perceive and experience one’s aging considerably differently. Subjective age (SA), referring to how individuals experience themselves as younger or older than their actual age, has been highlighted as an important predictor of late-life health outcomes. However, it is unclear whether and how SA is associated with the neurobiological process of aging. In this study, 68 healthy older adults underwent a SA survey and magnetic resonance imaging (MRI) scans. T1-weighted brain images of open-access datasets were utilized to construct a model for age prediction. We utilized both voxel-based morphometry (VBM) and age-prediction modeling techniques to explore whether the three groups of SA (i.e., feels younger, same, or older than actual age) differed in their regional gray matter (GM) volumes, and predicted brain age. The results showed that elderly individuals who perceived themselves as younger than their real age showed not only larger GM volume in the inferior frontal gyrus and the superior temporal gyrus, but also younger predicted brain age. Our findings suggest that subjective experience of aging is closely related to the process of brain aging and underscores the neurobiological mechanisms of SA as an important marker of late-life neurocognitive health.
Interleukin-6 as a Predictor of the Risk of Cardiovascular Disease: A Meta-Analysis of Prospective Epidemiological Studies

ABSTRACT Objective: The etiology of cardiovascular disease (CVD) is complex owing to the interactions of genetic variance with environmental factors. Inflammatory processes are now being increasingly implicated in the pathogenesis of CVD. This meta-analysis investigated the potential role of interleukin-6 (IL-6) as a risk factor for CVD development in healthy individuals. Methods: Literature search was carried out in multiple electronic databases, and study selection followed a priori eligibility criteria. Meta-analyses of standardized mean differences were carried out to determine an overall effect size of the difference in IL-6 levels between CVD cases and non-CVD matched controls. Meta-regression analyses were performed to examine the relationship between the IL-6 levels in CVD cases and several explanatory variables. Results: Seventeen studies enrolling 288738 healthy individuals with an average follow-up duration of 7.4 ± 4.1 years were found eligible. Overall, data of 5400 CVD cases and 14607 matched non-CVD controls are used in the present meta-analysis. Baseline IL-6 levels were significantly higher in CVD cases than in non-CVD controls (standardized mean difference [95% confidence interval]) of 0.14 [0.09, 0.20]/mean difference of 0.36 [0.28, 0.44] picogram per milliliter). Total cholesterol, LDL-cholesterol, and triglyceride levels were also significantly higher, and HDL-cholesterol levels were significantly lower in CVD cases in comparison with the controls. Systolic blood pressure and total cholesterol levels had a significantly positive relationship, whereas triglyceride levels had a significantly inverse relationship with the levels of IL-6. Conclusion: Higher IL-6 levels in healthy individuals are associated with CVD risk, which is co-associated with hypertension and hypercholesterolemia.
Phytoremediation efficiency of Brassica juncea cultivars at vegetative and reproductive growth stages under individual and combined treatment of fluoride and aluminium

ABSTRACT The objective of this study was to investigate phytoremediation ability of Brassica juncea cultivars for aluminium (Al) and fluoride (F) independently and in combination (Al + F). Out of 8 cultivars which were treated with Al, F, and (Al + F), 4 cultivars (Bio-902, Pusa-Tarak, CS-14, and Laxmi) were selected for further studies on the basis of growth parameters. These cultivars were exposed to soil (pH 5) supplemented with F (0, 25, 50, and 75 mg kg−1) and Al (0, 50, 100, and 150 mg kg−1) independently and in combination (Al + F) (0 + 0, 50 + 25, 100 + 50, and 150 + 75 mg kg−1). We found that the accumulation of F, Al, and (Al + F) was highest in the roots followed by grains, shoots, and leaves. When the plants were treated with Al or F separately, the accumulation of Al or F were less as compared to when treated in combination (Al + F). Conclusively, the results also showed that maximum tolerance index, uptake, and translocation factor for F were highest in CS-14, Al in Bio-902, and (Al+ F) in Pusa-Tarak, and were found to be the lowest in Laxmi.
α2- and β2-Adrenoreceptor-Mediated Efficacy of the Atypical Antidepressant Agomelatine Combined With Gabapentin to Suppress Allodynia in Neuropathic Rats With Ligated Infraorbital or Sciatic Nerve

Previous data showed that neuropathic pain induced by mechanical lesion of peripheral nerves has specific characteristics and responds differently to alleviating drugs at cephalic versus extracephalic level. This is especially true for tricyclic antidepressants currently used for alleviating neuropathic pain in humans which are less effective against cephalic neuropathic pain. Whether this also applies to the antidepressant agomelatine, with its unique pharmacological properties as MT1/MT2 melatonin receptor agonist and 5-HT2B/5-HT2C serotonin receptor antagonist, has been investigated in two rat models of neuropathic pain. Acute treatments were performed 2 weeks after unilateral chronic constriction (ligation) injury to the sciatic nerve (CCI-SN) or the infraorbital nerve (CCI-ION), when maximal mechanical allodynia had developed in ipsilateral hindpaw or vibrissal pad, respectively, in Sprague–Dawley male rats. Although agomelatine (45 mg/kg i.p.) alone was inactive, co-treatment with gabapentin, at an essentially ineffective dose (50 mg/kg i.p.) on its own, produced marked anti-allodynic effects, especially in CCI-ION rats. In both CCI-SN and CCI-ION models, suppression of mechanical allodynia by ‘agomelatine + gabapentin’ could be partially mimicked by the combination of 5-HT2C antagonist (SB 242084) + gabapentin, but not by melatonin or 5-HT2B antagonist (RS 127445, LY 266097), alone or combined with gabapentin. In contrast, pretreatment by idazoxan, propranolol or the β2 antagonist ICI 118551 markedly inhibited the anti-allodynic effect of ‘agomelatine + gabapentin’ in both CCI-SN and CCI-ION rats, whereas pretreatment by the MT1/MT2 receptor antagonist S22153 was inactive. Altogether these data indicate that ‘agomelatine + gabapentin’ is a potent anti-allodynic combination at both cephalic and extra-cephalic levels, whose action implicates α2- and β2-adrenoreceptor-mediated noradrenergic neurotransmission.