Miracle-dz/UniFAR-FTUs huggingface dataset:
Training in child and adolescent mental health for nursing, occupational therapy and social work students: does it influence career intentions?

Despite increased funding in child and adolescent mental health there remains a shortage of qualified health professionals working in this area in New Zealand. This study was designed to determine whether increasing training in child and adolescent mental health would increase undergraduate nursing, occupational therapy and social work students’ interest in working in the area. An additional aim of the study was to develop a sustainable teaching resource on child and adolescent mental health in CD-Rom format. Students participating in the study were asked to complete a questionnaire before and after attending a workshop in child and adolescent mental health and again at a follow-up point, three to 16 weeks later, to establish whether or not this had influenced their stated career intentions. To assess students’ and their educator’s perceptions of the quality and acceptability of the workshop a quality of teaching questionnaire was administered after the workshop. Three-hundred-and-seventy-three students participated in 14 workshops held in seven cities around New Zealand. The workshop had a positive impact on students’ career intentions in relation to child and adolescent mental health. A repeated measures analysis showed an overall time effect (F2,546 = 16.29, p = <0.0001). Further investigation of this difference was carried out using a multiple comparison test (Scheffe test) which showed a highly significant positive increase in career intentions between pre-workshop and post-workshop ratings (p = <0.0001), which dropped between post-workshop and follow-up (p = 0.004), with no change between pre-workshop and follow-up ratings (p = 0.43). There was no differential effect by students’ professional group (p = 0.08), ethnicity (p = 0.6), gender (p = 0.75) or age (p = 0.26). The study reflected similar career intention trends found in the literature. In particular, at base-line there were differences in profession-specific career intentions. Job attributes such as job satisfaction, personal interest, a job with supports available and being able to help people were also factors influencing students’ career intentions. The present study showed that a workshop on child and adolescent mental health had a significant immediate impact on undergraduate students’ career intentions.
Abstract S1-05: Tumor infiltrating lymphocytes (TILs) indicate trastuzumab benefit in early-stage HER2-positive breast cancer (HER2+ BC)

BACKGROUND: We have previously shown that TILs are predictive of benefit to trastuzumab and chemotherapy in HER2+ BC in the FinHER study, an adjuvant, phase III study in early-stage BC, where HER2+ patients were randomized to 9 weeks of trastuzumab or no trastuzumab in addition to chemotherapy (Loi et al, ASCO 2012). We sought to further confirm this positive association as well as to understand the composition of TILs. METHODS: The association between TILs and response to trastuzumab with chemotherapy (epirubicin/cyclophosphamide with docetaxel with or without capecitabine) was evaluated in 156 HER2+ patients from the neoadjuvant GeparQuattro trial. The primary correlative endpoint was the association between TILs (quantified using the same method as previously published) with pathological complete response rates (pCR), adjusted for clinicopathological characteristics. To understand the composition of TILs, correlations between TILs and gene expression levels of 13 pre-defined immune markers were evaluated from 202 HER2+ samples from the FinHER study. These represented T and B cell infiltration (CD3D, IGKC), Th1 (IFNG, CD8A), chemoattractants (CXCL9, CXCL13), immunosuppression (VEGFA, FOXP3, IDO1) and T-cell checkpoint receptors and ligands (PD-1, PD-L1, CTLA-4, CD80). Prognostic associations and interactions with trastuzumab were studied in Cox regression models for distant-disease free survival (DDFS). Preclinical mice models of HER2 mammary cancer were used to investigate combination therapies. RESULTS: In the GeparQuattro trial data, each 10% increment in TILs was associated with higher rates of pCR (adjusted OR:1.14 95%CI:1.01-1.29;P = 0.037) after neoadjuvant trastuzumab and chemotherapy supporting the findings from the FinHER study. Gene expression analyses using the FinHER samples revealed IDO1 and CXCL13 were most highly correlated with TILs (R = 0.58 and 0.51;p We next postulated that enhancing T-cell responses would be synergistic with trastuzumab. Trastuzumab in combination with several inhibitors of T-cell negative regulation (anti-CTLA4, anti-PD-1, anti-PD-L1) resulted in higher tumor regressions compared with monotherapy in a mouse transplant model of HER2+ mammary cancer. In particular, anti-PD1 (P = 0.02) and anti-PD-L1 (P = 0.008) were most effective. In a BALB/c-MMTV-neu transgenic mice mouse model (i.e. immune tolerant to HER2 antigen), the combination of trastuzumab and anti-PD1 antibody could significantly delay mammary gland tumor formation (p CONCLUSIONS: We confirm that TILs are associated with higher responses to trastuzumab and chemotherapy. Furthermore, tumor-mediated immunosuppression is evident in the lymphocytic infiltrate with PD-1 and IDO1 significantly predictive of trastuzumab benefit. The addition of a T-cell checkpoint inhibitor in a preclinical model significantly enhanced trastuzumab responses. These combinations warrant evaluation in the clinical setting. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr S1-05.
Laser-assisted posterior cordotomy for bilateral vocal fold paralysis: Our experience

Introduction: Bilateral vocal fold paralysis (BVFP) is a relatively uncommon cause of respiratory distress. The goals of surgical treatment are an improvement in airway size by enlarging the glottis, thus, eliminating the need for tracheostomy, while at the same time avoiding a breathy voice and aspiration. Striking this balance is extremely important. Unilateral laser-assisted posterior cordotomy provides sufficient airway at posterior glottis while preserving phonatory and protective functions of the larynx. Aims: To evaluate long-term acoustic, aerodynamic and functional results of laser-assisted unilateral posterior cordotomy in BVFP. Materials and Methods: The prospective study includes seven patients of BVFP who underwent unilateral laser-assisted posterior cordotomy. Surgical success was evaluated regarding decannulation rate, time to decannulation and need for the second procedure. Voice assessment was done using voice handicap index (VHI), grade, roughness, breathiness, asthenia, strain and measurement of maximum phonation time (MPT). Effect of deglutition was assessed by the presence or absence and duration of aspiration. Observations and Results: Of seven patients, four had been tracheostomized at some time during their treatment. They were successfully decannulated within an average of 1 week after the surgery. The postoperative respiratory function was adequate for more than routine activity in all patients. None of the patients required a second procedure. VHI values demonstrated that while four patients had no/mild degree of voice handicap, two had moderate and one had a severe degree of handicap. While five patients had a normal MPT, two had a reduced MPT. Perceptual rating by a speech pathologist revealed that while two patients had mild dysphonia, four had moderate dysphonia. None of the patients complained of aspiration postoperatively. Conclusion: Unilateral CO2laser posterior cordotomy is a simple, safe and short surgical technique that creates a satisfactory glottic airway to improve respiration while avoiding aspiration and having minimal to the mild effect on the voice.
Adapting probability-transitions in DP matching processing for an oral task-oriented dialogue

A system is presented which has been developed to evaluate the introduction of voice technologies in air-traffic controller training. The dialogue system is designed to replace the pseudopilot, a human playing the role of the pilot during training exercises and communicating both with the student controller and with the air-traffic simulator which updates the radar image on a screen. The knowledge representation which renders the cooperation of different knowledge sources possible is described. The approach makes use of pragmatic knowledge to predict a sublanguage which dynamically limits the recognition search space and therefore improves the accuracy. Recognition experiments in a task-simulation environment indicate that the combined use of both dynamic probabilities and dialogue strategies allows the system to obtain performance equal to 96.5% at the sentences level. <<ETX>>
Exploring the synergistic use of multi-scale image object metrics for land-use/land-cover mapping using an object-based approach

This study presents a new method for the synergistic use of multi-scale image object metrics for land-use/land-cover mapping using an object-based classification approach. This new method can integrate an object with its super-objects’ metrics. The entire classification involves two object hierarchies: (1) a five-level object hierarchy to extract object metrics at five scales, and (2) a three-level object hierarchy for the classification process. A five-level object hierarchy was developed through multi-scale segmentation to calculate and extract both spectral and textural metrics. Layers representing the hierarchy at each of the five scales were then intersected by using the overlay tool, an intersected layer was created with metrics from all five scales, and the same geometric elements were retained as those of the objects of the lowest level. A decision tree analysis was then used to build rules for the classification of the intersected layer, which subsequently served as the thematic layer in a three-level object hierarchy to identify shadow regions and produce the final map. The use of multi-scale object metrics yielded improved classification results compared with single-scale metrics, which indicates that multi-scale object metrics provide valuable spatial information. This method can fully utilize metrics at multiple scales and shows promise for use in object-based classification approaches.
The use of Wharton's jelly-derived mesenchymal stem cells to accelerate second-intention cutaneous wound healing in goat.

ObjectiveThis study was performed to evaluate the effects of caprine Wharton's jelly MSCs transplantation on second intention cutaneous wound healing. DesignExperimental study. AnimalsFive healthy Raeini goats. ProceduresAfter collection of caprine pregnant uterus of mixed breed goats from abattoir, the Wharton's jelly of umbilical cord was harvested. The tissues were minced in ventilated flasks and explant culture method was used for separating MSCs. To investigate the stem cell properties, after evaluation of cell morphology and cell behavior in culture medium, the isolated cells were immunostained for Actin protein, histochemically assayed for the presence of alkaline phosphatase activity. After confirmation of stem cell properties of isolated cells, 9×10 MSCs were stained with BrdU and prepared for transplantation to each wound. Rectangular (3×3 cm) full thickness skin wounds were made on the both sides of thoracic vertebrate of 5 Raeini goats. The left wounds were implanted with MSCs and right wounds were considered as control group (without cell transplantation). The wound healing process (%wound contraction, %wound epithelialization, and %wound healing) were compared morphometrically between two groups, during 5 weeks study. ResultsThe isolated cells in present study were fusiform or spindle-form cells and able to form cell colony in culture medium. They showed a positive response to immunohistochemical staining of α-actine smooth muscle and alkaline phosphates. Immunohistochemical staining with monoclonal antibodies against BrdU of labeled cells confirmed that the transformed cells were still alive in the wound bed. Morphometric evaluation of wounds showed that wound contraction, re-epithelialization, and healing percentage in treated wounds with MSCs were significantly more than control wounds during 5 week study (P<0.05). ∗ Corresponding author: Omid Azari, DVSc Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Iran. E-mail address: omidazari@mail.uk. ac.ir
Reculturing curriculum within a nursing context in Taiwan : an action research approach

The focus of this study is on curriculum change within a nursing institute in Taiwan where there is a growing demand for reform to nurse education in order to produce more competent practitioners. I conceptualised a framework to guide the transformation process in ways that were empowering, sustainable and generative. I argued that curriculum change also involves the beliefs, customs, attitudes or expectations of those who participate in the process: essentially it is a reculturing process. My conceptual framework included notions such as student-centredness, reculturing, collaborative practices and reflections, personal growth, and professional development. A plan of action was developed based on the notions contained in the conceptual framework and carried out within an Action Research methodology. Action Research provided the mechanism by which the collaborators explored and understood their conceptions of teaching and learning and then planned and implemented action to change the current situation, and evaluate and reflect on the transformations. Strategies such as personal practical theorising, focus group, critical debate, and collaborative reflection were used to bring about the curriculum change. The significance of this study lies in its practical contribution to all aspects of curriculum making including innovation, planning, implementation and ongoing review. Although information generated from this study is not generalisable, lessons learned from it may be utilised by other educational institutes with similar issues and similar contexts.
Interação cuidador familiar-pessoa com AVC: autonomia compartilhada

Trata-se de um estudo qualitativo, utilizando-se como referencial metodologico a Grounded Theory e como referencial teorico o Interacionismo Simbolico, para compreender a experiencia de cuidadores familiares de pessoas com AVC, acerca das modalidades de cuidado adotadas por eles, durante o processo de reabilitacao de uma pessoa com AVC no domicilio. Tais modalidades podem ser exercidas: incentivando o doente a recuperar a sua autonomia; e nao estimulando a autonomia do doente. Ao inter-relacionar os componentes relativos a experiencia, evidenciamos que o proprio cuidador familiar percebe que os processos de retomada da autonomia - da pessoa vitimada pelo AVC e de sua propria - se configuram como interdependentes e condicionados ao nivel de reabilitacao alcancado pelo doente.
The Impact of Insurance and HIV Treatment Technology on HIV Testing

This paper investigates the effects of health insurance and new antiviral treatments on HIV testing rates among the U.S. general population using nationally representative data from the Behavioral Risk Factor Surveillance Survey (BRFSS) for the years 1993 to 2002. We estimate recursive bivariate probit models with insurance coverage and HIV testing as the dependent variables. We use changes in Medicaid eligibility and distribution of firm size over time within a state as instruments for insurance coverage. The results suggest that (a) insurance coverage increases HIV testing rates, (b) insurance coverage increases HIV testing rates more among the high risk population, and (c) the advent of Highly Active Antiretroviral Therapy (HAART) increases the effects of insurance coverage on HIV testing for high risk populations.
Study to assess the extent of maternal health care utilization by women residing in urban slum area in Ahmedabad

Background: Maternal mortality is on an average 18 times higher in developing countries as compared to developed countries. Despite the existence of many national programs for improving maternal and child health, maternal mortality and morbidity continue to be at higher side, at an unacceptable level. Objective: (1) To know the extent of maternal health care utilization; (2) To study the factors affecting utilization of maternal care services. Materials and Methods: The cross-sectional study was conducted in an urban slum during September and October 2014. A pretested questionnaire was used to collect data. All married women in the age group of 15–45 years who were either pregnant at time of interview or had delivered within last 1 year were included. A total of 100 such women identified by door-to-door survey participated in the study after getting informed oral consent. Data were entered in Microsoft Excel and was analyzed in Epi Info 7. “P” < 0.05 was considered statistically significant. Result: Around 80% respondents received antenatal care (ANC) and 20% did not seek ANC. Overall, ANC registration was quite good (92%) but within first trimester it was only 58%. Immunization for tetanus was 79% but consumption of iron and folic acid tablets was 76%. Reason for inadequate utilization was mainly due to either unawareness or financial constraints. Conclusion: The utilization of ANC services and deliveries at health centers were significantly associated with education of the women, education of their spouses, and socioeconomic status of the family.
Analysis of hybrid linear parameter-varying systems

This paper proposes a new hybrid linear parameter-varying (LPV) systems and investigates some characteristics of these systems. A hybrid LPV system is defined by a ser of LPV systems and average dwell-time as a model of discrete event dynamics. This system encompasses typical LPV systems and emerging hybrid systems such as reconfigurable flight control. The hybrid LPV system is then analyzed using multiple parameter-dependent Lyapunov functions. This type of Lyapunov function is allowed to be discontinuous so that it significantly can generalize the class of Lyapunov functions used in the existing (switched) LPV systems and accommodate some characteristics of hybrid systems. With a benchmark LPV system, the proposed approach is shown to reduce the conservatism of the existing Lyapunov-based LPV approaches.
Pattern of left ventricular geometry in hypertension: a study of a hypertensive population in Nigeria.

Background: Hypertension is a leading cause of cardioxasular morbidity and mortality in Nigeria. The main aim of this study was to deterine the prevalence of left ventricular hypertrophy and left ventricular geometric patterns among hypertensives in Kano, Nigeria. Methods: The study was cross-sectional in design, and carried out in 3 echocardiography laboratories within the City of Kano, Nigeria. Patients with hypertension without other cardiac disorders were serially recruited and studied after obtaining informed consent. Results: A total of 186 patients were studied over 7 months; 89 males (47.9%) and 97 females (52.1%). The prevalence of left ventricular hypertrophy was 61.8%. Thirty five patients (18.8%) had normal left ventricular geometry and these were predominantly females and had the lowest mean age and shortest duration of hypertension. Sixty eight patients (36.6%) had eccentric hypertrophy, 47 (25.3%) had concentric hypertrophy and 36 (19.4%) had concentric remodelling. Independent predictors of the various geometric patterns were identified. Conclusion: A high prevalence of left ventricular hypertrophy was observed with eccentric hypertrophy being the most common geometric pattern. Gender influenced the pattern of left ventricular geometry.
ASSISTIVE TECHNOLOGY USE AMONG SECONDARY SPECIAL EDUCATION TEACHERS IN A PRIVATE SCHOOL FOR STUDENTS WITH SPECIFIC LEARNING DISABILITIES: TYPES, LEVELS OF USE AND REPORTED BARRIERS.

Title of Document: ASSISTIVE TECHNOLOGY USE AMONG SECONDARY SPECIAL EDUCATION TEACHERS IN A PRIVATE SCHOOL FOR STUDENTS WITH SPECIFIC LEARNING DISABILITIES: TYPES, LEVELS OF USE AND REPORTED BARRIERS. Carmen Constantinescu, Doctor of Philosophy, 2015 Directed By: Dr. Margaret McLaughlin Department of Counseling, Higher Education, and Special Education Special education teachers are expected to integrate assistive technology (AT) for students with disabilities per Individuals with Disabilities Education Act (IDEA). However, the legal mandates do not provide clear guidelines regarding the type, the frequency, and the purpose for which AT can be used and, often, the decision of AT integration is left up to teachers and members of Individualized Educational Plan (IEP) teams who may or may not have complete knowledge of the AT implementation strategies. This research study provides an overview of how teachers of different content areas in a technology-rich self-contained secondary program for students with learning disabilities implemented AT in their daily instruction. Teacher reports and observations reflected discrepancies in how teachers may perceive their teaching with AT and revealed that, in spite of having access to a variety of technologies, there continues to be a focus on using low and medium AT (less complex technology). Specific factors (barriers) that influenced the integration of technology for students with learning disabilities are also investigated and described. ASSISTIVE TECHNOLOGY USE AMONG SSECONDARY SPECIAL EDUCATION TEACHERS IN A PRIVATE SCHOOL FOR STUDENTS WITH SPECIFIC LEARNING DISABILITIES: TYPES, LEVELS OF USE, AND REPORTED BARRIERS.
Classifying the Duat

Summary The notion of Duat plays a major role in ancient Egyptian funerary beliefs. Yet, a single definition of this notion is impossible to achieve, as it underwent a process of evolution over thousands of years without ever designating just one unambiguous place at a time. In this context, an approach based on cognitive linguistics and on the significance of the determinatives accompanying the word Duat can be exploited to shed more light on this elusive concept. The focus will be here on the Pyramid Texts and the Coffin Texts as well as the intermediary phase of transmission of the funerary literature during the period between the end of the Old Kingdom and the beginning of the Middle Kingdom.