Miracle-dz/UniFAR-FTUs huggingface dataset:
Left ventricular deformation in relation to the geometric pattern in hypertensive patients

Abstract This study aimed to evaluate left ventricular deformation in relation to the geometric pattern in hypertensive patients with normal left ventricular ejection fraction using speckle tracking echocardiography (STE). Transthoracic echocardiography was performed in 80 hypertensive patients and 50 age- and gender-matched normotensive subjects. Left ventricular geometric pattern was defined according to left ventricular mass index and relative wall thickness as normal geometry, concentric remodeling, concentric hypertrophy, and eccentric hypertrophy, respectively. Quantitative measurements of longitudinal, circumferential, and radial strain were performed for endocardial, middle, and epicardial layers of the left ventricular wall at each segment. The longitudinal strain in hypertension was lower for all 3 layers in concentric (n = 20) and eccentric hypertrophy (n = 20) than normotensive subjects (n = 50, P < .01). It was also significantly lower for the endocardial layer in concentric remodeling (n = 20, P = .04 vs normotensive subjects). The circumferential strain in hypertension was higher in normal geometry or concentric remodeling, lower in concentric hypertrophy, and at similar level in eccentric hypertrophy, in comparison with normotensive subjects. The difference from normotensive subjects was statistically significant for the endocardial and middle layers in normal geometry (P < .03), for the endocardial layer in concentric remodeling (P < .02), and for the middle and epicardial layers in concentric hypertrophy (P⩽.001). The radial strain and twist did not differ between normotensive and hypertensive subjects (P > .08). Left ventricular deformation in hypertension occurs with various geometric patterns disproportionately in the endocardial, middle and epicardial layers and differently in the longitudinal and circumferential orientations.
Uses of Ultrasound and Doppler in Assessment of Endometrial Receptivity in Patients of Unexplained Infertility

Background:although the majority of infertile couples was found to have an identifiable male or female factor, 15–30% was categorized as having ‘‘unexplained infertility’’. The endometrium is considered to be a key determinant in successful implantation. Endometrial receptivity is regulated by many factors including endometrial perfusion. Aim of the Work: this study aimedto detect the role of the two dimensional ultrasound and Doppler ultrasonographic uterine markers of implantation in patients of unexplained infertility compared to fertile participants. Patients and Methods: the study was performed on 50 patients presented to the outpatient clinic in Al-Hussein, Bab El-Shearia (Sayed Galal) Hospitals, Al-Azhar University from October 2017 to August 2018 and they were categorized into two groups: Group A (Patients group): it was included 30 participants presented with unexplained infertility. Group B) (Control group) who included 20 fertile women coming for contraception. Results: there was a significant statistical difference as regard the endometrial thickness between cases and controls, and the controls had a thicker endometrium. Lower pulsatility index (PI) in uterine artery in the controls compared to the infertile group. Increased sub endometrial vascularization in the controls compared to the infertile group. Conclusion:ultrasound as well as Doppler studies of the endometrial and subendometrial vascularization had a role in predicting endometrial receptivity. Uterine artery Doppler study and the endometrial thickness measurement had a role in detection of uterine receptivity.
Post-Permanency: An Assessment for Families’ Needs for Services and Supports

This article reports the results of a qualitative study that sought the perspectives of birth parents and adoptive parents following reunification or adoption of children from foster care. Using a participatory action design that actively involved young adults formerly in foster care and parents in the design and implementation of the study, the study focused on the consumers’ perspectives on several issues related to permanency. The article reports findings from interviews with a subset of 27 birth and adoptive families in New York City who were asked about their postpermanency experiences and from interviews with 38 child welfare professionals who were asked to respond to the parents’ perspectives. The article offers directions for child welfare practice and program development.
Neoadjuvant therapy for rectal cancer: Mature results from NSABP protocol R-04.

390 Background: The primary aims were to: 1) compare capecitabine (Cape) and continuous intravenous infusion (CVI) 5-FU combined with pelvic radiation therapy (RT) given preoperatively for patients (pts) with stage II or III rectal cancer; 2) determine whether the addition of oxaliplatin (Ox) would improve pt outcomes. Preliminary results focusing on pathologic complete response, sphincter-sparing surgery, surgical downstaging, and toxicity were presented at ASCO 2011 (Roh: J Clin Oncol 29: 2011 Ab 3503). Methods: Pts with clinical stage II or III rectal cancer undergoing preoperative RT (4,500cGy in 25 fractions over 5 wks + boost of 540cGy-1080cGy in 3-6 daily fractions) were randomly assigned to one of four chemotherapy regimens in a 2x2 design: CVI 5-FU (225mg/m2 5 days/wk), with or without intravenous Ox (50mg/m2 /wk x 5) or oral Cape (825 mg/m2 BID 5 days/wk), with or without Ox (50mg/m2/wk x 5). The primary endpoint of local-regional (L-R) tumor control included L-R tumor recurrence, less than an R.
New observations on Proboscia auxospores and validation of the family Probosciaceae fam. nov.

Le re-examen d'anciens echantillons d'eau en provenance de l'Ocean Austral a revele la presence d'auxospores de Proboscia alata a differents stades de developpement. Alors que les etudes precedentes avaient decrit les auxospores de Proboscia comme possedant de multiples colonnes ou rangees de copulae, il est ici propose que ce sont des ecailles, et qu'elles different des copulae provenant du developpement de la cellule initiale dans l'auxospore. La cellule initiale comporte toutes les caracteristiques distinctives de la cellule vegetative, bien que des aretes en forme de pli aient ete observees longitudinalement le long du proboscis de la valve initiale. Le diametre de la cellule initiale (40.0-45.0 μm) est generalement 3-4 fois plus grand que celui de la cellule gametangiale (16.3-17.6 μm). Ces dimensions suggerent qu'il s'agit d'une grande forme de P. alata. De maniere un peu surprenante, les auxospores provenant de l'Ocean Austral sont occasionnellement bifides a l'extremite opposee a la cellule gametangiale. On montre ici que cette bifurcation correspond a deux proboscis bien individualises (avec une structure en forme de pli, similaire a celles de la valve initiale), chacun portant un anneau de spinules et une fissure longitudinale. Cependant, il n'y a pas de point d'ancrage et les proboscis n'apparaissent pas connectes a une valve, de telle sorte qu'il n'y a pas de distinction apparente entre la paroi de la valve et celle de l'auxospore. La raison pour laquelle certaines auxospores produisent une terminaison bifide plutot qu'une cellule initiale demeure inconnue. Un specimen provenant de la mer de Sulu apparait comme etant une auxospore de Proboscia indica au vu de sa grande dimension (au moins 100 μm de diametre). Etant donnee la confusion liee a l'identification de ce taxon, nous avons passe en revue la litterature et nous fournissons une description plus detaillee de cette espece. Proboscia indica montre des caracteristiques qui peuvent permettre de distinguer cette espece de P. alata et des taxons voisins: les dimensions du frustule et de la valve sont plus grandes que pour les autres especes, comme chez P. alata l'agencement de la chaine est asymetrique du a l'existence de « points d'ancrage decales », le long proboscis est plus fortement incline que chez P. alata, chaque « pore interloculaire » est encadre par 4 et non 6 loculi, l'auxospore ne developpe pas d'extremite bifide, et ce taxon se rencontre dans les mers tropicales a temperees et non dans les eaux polaires. Enfin, la famille des Probosciaceae est ici re-erigee comme nouveau taxon, avec une diagnose en latin en accord avec les regles de la nomenclature botanique.
Analysis of Reinforcement Based Adaptive Routing in MANET

This paper describes and evaluates the performance of various reinforcement learning algorithms with shortest path algorithms that are widely used for routing packets through the network. Shortest path routing is the simplest policy used for routing the packets along the path having minimum number of hops. In high traffic or high mobility conditions, the shortest path get flooded with huge number of packets and congestions occurs, So such shortest path does not provides the shortest path and increases delay for reaching the packets to the destination. Reinforcement learning algorithms are adaptive algorithms where the path is selected based on the traffic present on the network at real time. Thus they guarantee the least delivery time to reach the packets to the destination. Analysis done on a 6 by 6 irregular grid and sample ad hoc network shows that performance parameters used for judging the network - packet delivery ratio and delay provides optimum results using reinforcement learning algorithms.
Bacterial Isolates in Blood Culture of Children with Septicemia.

Background: Septicemia is a common condition in children with a resultant high morbidity and mortality. It’s defined as the presence of bacteria in the blood and is often associated with severe infections, the alternative names (Blood poisoning, Bacteremia with sepsis, systemic inflammatory response syndrome). Objective: To study the etiological agents and antibiotics susceptibility of septicemia in children admitted to Central Teaching Hospitals of Pediatric.Patients and Methods: A total of 80 patients having signs and symptoms of Septicemia who were admitted to Central Teaching Hospital of Pediatric in Baghdad city. Samples were obtained during the period from the 1st January till the 30 th of February 2011. Bacteriological specimen (blood) collection, isolation and Identification of causative microorganism by colonial morphology, Gram stains, Biochemical tests and other tests used for further identification (Catalase, Coagulase, Oxidase test) and determining susceptibility of bacteria to antibiotics and chemotherapeutic agents.Results: The blood culture results showed that 20 (25.0 %) patients gave positive blood culture, 60 (75.0 %) patients gave negative blood culture. The microorganisms isolated from blood cultures of 20 patient gave positive blood culture with septicemia was Staphylococcus aureus 5 (25.0 %) Escherichia coli 5 (25.0 %), Klebsiella pneumonia 4 (20.0 %), Enterobacter spp 3 (15.0 %), Serreatia 2 (10.0 %), Pseudomonas spp 1 (5.0 %), and the frequency of septicemia in 20 case according to gender represented male 11 (55.0 %), female 9 (45.0 %). Conclusions: Positive blood cultures were obtained in 20 (25.0 %) of children. The commonest Gram positive bacterial isolate was Staphylococcus aureus and Gram negative bacterial isolate was Escherichia coli especially in males sex, in neonate age group who were delivered by cesarean section and preterm < 37 weeks gestational age. The antibiotics [Cefotaxime, Amoxicillin+ Clavulanic acid] are the most effective against Staphylococcus aureus and [Gentamycin, Amikacin, Imipenem] against Gram negative bacteria.
Medium-term outcome of cementless, mobile-bearing, unicompartmental knee arthroplasty.

Background Cemented, mobile-bearing unicondylar knee arthroplasty (UKA) yields good functional results. However, radiolucent lines (RLL) are not uncommon, even in asymptomatic patients, and it has been debated whether these "physiological" RLLs are indicative of loosening. Cementless UKA may lead to fewer RLLs compared with cemented devices. The present study was designed to document mid-term outcome with an emphasis on clinical outcomes. Methods We included 153 knees of 150 consecutive patients in a retrospective study. All patients had received a cementless medial mobile-bearing UKA. Patients were evaluated with use of the Knee Society Score (KSS), which was obtained at baseline and at final follow-up. The WOMAC, Oxford Knee Score (OKS) and Forgotten Joint Scores (FJS-12) were administered at the final follow-up. Anteroposterior (AP) and lateral radiographs were taken at final follow-up. Results At a mean follow-up of 5 years (range, 3-7 years), implant survival was 97.1% (95% confidence interval, 91.1-99.1%). Excellent postoperative KSS, WOMAC, OKS and FJS scores were obtained. Postoperative radiography was available for 78 knees. RLL was observed in 10.3% of the cases, but no cases with complete RLLs were seen. Conclusions Favourable results were found for cementless, mobile-bearing UKA, with no aseptic loosening at an average follow-up of 5 years. Cementless UKA fixation may lead to a clinically "forgotten joint" and may decrease the rate of RLLs.
A hypothesis: CRISPR-Cas as a minimal cognitive system

Concerning what signifies the minimal requirements for a process to be designated cognitive, various criteria have been proposed, but the problem has not been settled. The important thing to consider in establishing the criteria is which criterion has stronger explanatory power. Recent developments in immunology demonstrate that the immune system is omnipresent in the realm of living beings, including bacteria and archaea. Although the structural characteristics of immune systems are significantly different among species, the fundamental functional components, namely, recognition, information integration, reaction, and memory, are well conserved. Interestingly, these adaptive features are superimposed on those of the central nervous system. Given that adaptive cognitive ability is a prerequisite for the existence and the survival of living organisms, these results may be compatible with the idea that in bacteria without an apparent nervous system, the immune system performs neural-like functions. The presence of the clustered regularly interspaced palindromic repeats (CRISPR)-CRISPR associated protein (Cas) systems as a cognitive system in the earliest living organisms suggests that one of the fundamental functions is conserved throughout evolution. Furthermore, this interpretation can evade the critiques against the current biological paradigm that demand that cognitive mechanisms be preceded by organisms in the earlier stages of evolution, thus providing better and stronger explanatory power. I thus propose that genetic and biochemical machinery represented by the bacterial immune system serves as a minimal cognitive system.
Lid lesions suspected of malignancy.

BACKGROUND: This review describes four examples of lid lesions and their clinical or surgical management. METHODS: Close examination and careful observation of the lids and surrounding tissue is necessary for early detection and diagnosis of skin lesions. Although skin carcinomas around the lids are usually not life threatening, delayed diagnosis can lead to extensive surgical intervention and cosmetic reconstruction. This review describes the epidemiology and clinicopathologic basis for the development of lid carcinomas. RESULTS: The differential diagnosis of lid lesions is reviewed and current accepted methods of therapy are discussed. CONCLUSIONS: Lid lesions are typically classified into malignant and benign categories. Beyond this general classification, knowledge of initial appearance, progression and potential pathologic change is necessary. Clinical presentations and management of both malignant and benign lid lesions are discussed.
Implication of calcium activated RasGRF2 in Annexin A6-mediated breast tumor cell growth and motility

The role of AnxA6 in breast cancer and in particular, the mechanisms underlying its contribution to tumor cell growth and/or motility remain poorly understood. In this study, we established the tumor suppressor function of AnxA6 in triple negative breast cancer (TNBC) cells by showing that loss of AnxA6 is associated with early onset and rapid growth of xenograft TNBC tumors in mice. We also identified the Ca2+ activated RasGRF2 as an effector of AnxA6 mediated TNBC cell growth and motility. Activation of Ca2+ mobilizing oncogenic receptors such as epidermal growth factor receptor (EGFR) in TNBC cells or pharmacological stimulation of Ca2+ influx led to activation, subsequent degradation and altered effector functions of RasGRF2. Inhibition of Ca2+ influx or overexpression of AnxA6 blocked the activation/degradation of RasGRF2. We also show that AnxA6 acts as a scaffold for RasGRF2 and Ras proteins and that its interaction with RasGRF2 is modulated by GTP and/or activation of Ras proteins. Meanwhile, down-regulation of RasGRF2 and treatment of cells with the EGFR-targeted tyrosine kinase inhibitor (TKI) lapatinib strongly attenuated the growth of otherwise EGFR-TKI resistant AnxA6 high TNBC cells. These data not only suggest that AnxA6 modulated Ca2+ influx and effector functions of RasGRF2 underlie at least in part, the AnxA6 mediated TNBC cell growth and/or motility, but also provide a rationale to target Ras-driven TNBC with EGFR targeted therapies in combination with inhibition of RasGRF2.
AVALIAÇÃO DO AUTOCUIDADO NOS PORTADORES DE INSUFICIÊNCIA CARDÍACA

The objective in this study was to characterize the clinical and sociodemographic profile of heart failure patients and to describe the self-care behavior. Descriptive and cross-sectional study with a non-probabilistic sample of 57 cardiology nursing patients at a public hospital in Recife, Brazil, between May and September 2016. The self-care was assessed by means of the Self-Care of Heart Failure Index version 6.2, Brazilian version. The participants’ mean age was 62.9 years; 31 (54.4%) men; 36 (63.2%) literate; 26 (45.6%) suffering from hypertensive etiology and 30 (52.6%) in functional class III. The mean scores for the subscales indicated inappropriate self-care (self-care maintenance: 43.3; self-care management: 37.5 and confidence in self-care: 54.3). Higher scores were associated with education, with literate participants obtaining a mean score of 61 points (p=0.002). Investments are needed to improve self-care and nursing can play a relevant role in this improvement.
AutoML with Monte Carlo Tree Search

The sensitivity of machine learning (ML) algorithms w.r. t. their hyper-parameters and the difficulty of finding the ML algorithm and hyper-parameter setting best suited to a given dataset has led to the rapidly developing field of automated machine learning (AutoML), at the crossroad of meta-learning and structured optimization. Several international AutoML challenges have been organized since 2015, motivating the development of the Bayesian optimization-based approach Auto-Sklearn (Feurer et al., 2015) and the Bandit-based approach Hyperband (Li et al., 2016). In this paper, a new approach, called Monte Carlo Tree Search for Algorithm Configuration (Mosaic), is presented, fully exploiting the tree structure of the algorithm portfolio and hyper-parameter search space. Experiments (on 133 datasets of the OpenML repository) show that Mosaic performances match that of Auto-Sklearn.
Depression and Burnout Frequency in Nurses Working in Tertiary Intensive Care Units

Objective: Emotional and physical burden is heavy in the intensive care unit (ICU) employees, and the risk of burnout has significantly increased. The purpose of this study is to determine the frequency of burnout and depression in nurses serving in tertiary ICUs in a university hospital by questionnaire. Material and Methods: The questionnaire study was conducted on nurses studying actively in Dokuz Eylül University School of Medicine Anesthesia and Internal Medicine ICU between 22-26 August 2016. Burnout was assessed by Maslach Burnout Scale (MBS) and depression with Beck Depression Scale (BDS). Results: According to the BDS score, 29 nurses (58%) noted various degrees of depression from mild mood to severe depression. According to MBS, 6 of the nurses (12%) had a moderate risk of emotional exhaustion (DT) while 43 (86%) had a high risk. In terms of depersonalization (D), it was found that nurses had a moderate risk of 15 (30%) and a high risk of 22 (44%). There was a positive but weak correlation between duration of study and D in ICU (r=0.349, p=0.014). Nurses with no depression were found to have a a statistically significantly lower risk for DT (p=0.006) and personal failure (PF) (p=0.022). Conclusion: In this study, it was seen that the questionnaire evaluation of nurses working in the tertiary ICU showed a great deal of risk of depression and burnout. We believe that taking environmental, managerial and institutional measures and regular monitoring to reduce occupational risks and improve working conditions will reduce both depression and burnout frequency in this profession group.
Platelet indices in children with urinary tract infection

Urinary tract infection is one of the most common infections in children and may lead to serious morbidity and mortality in children. UTI associated with high grade vesicoureteral reflux (VUR) can lead chronic pyelonephritis and eventual renal scarring which are components of reflux nephropathy. Early diagnosis and prompt antimicrobial treatment are required to minimize renal scarring and progressive kidney damage.
Estimation of Serum Urea, Creatinine and Uric Acid in Obese Subjects

Introduction - Obesity is often a neglected renal risk factor. It may play a important role in progression of renal disease. Aim and Objectives - To estimate blood urea, serum creatinine, serum uric acid in Obese and control group. Method and Material - Total 50 obese subjects and 50 controls were taken for study. Serum /plasma urea ,serum creatinine and serum uric acid was measured on fully automated XL-640 , using Erba diagnostic kits. Observation and Results - The mean values of study parameters was found to be elevated in obese group as compared to controls . Result was expressed in Mean ± S.D. Conclusion - Renal profile was altered in obese subjects with increased levels of serum/plasma urea, serum creatinine, serum uric acid.
The association between psychosocial work factors and future low back pain among nurses in Hong Kong: A prospective study

This prospective study investigated how psychosocial work factors are associated with new or recurrent low back pain (LBP) among nurses in Hong Kong. A 12-month prospective study was conducted among Hong Kong nurses. Two hundred and thirty-six participants from six district hospitals completed a face-to-face baseline interview and were followed-up by telephone interview. The main psychological work outcome measures included relationships with colleagues, relationships with seniors or supervisors, overall work satisfaction, being under stress and level of enjoyment of her/his work. For the rate of LBP, 12-month incidence of and recurrent LBP were 39% and 62%, respectively. Of the psychosocial risk factors at work that were studied, this prospective study found association between poor work relations with colleagues (adjusted relative risk (RR) = 1.85), comparatively new in the current ward (adjusted RR = 3.29), low mood (adjusted RR = 2.41) and an increased risk of new LBP, but not for recurrent LBP in the sample of nurses in the hospital setting. Our results suggest that one of the potentials to prevent LBP among nurses is likely to lie in facilitating work relations such as teambuilding exercises at the workplace, especially on those who are less experienced in the current ward type.