Miracle-dz/UniFAR-FTUs huggingface dataset:
Preliminary Results of the ‘Surgiligtm’ Synthetic Ligament in the Management of Chronic Acromioclavicular Joint Disruption

Background Chronic instability of the acromioclavicular joint is relatively common and normally occurs following a fall onto the point of the shoulder. Reconstruction of the joint [Weaver-Dunn procedure] using the coracoacromial ligament is often required in service personnel, and a number of methods to augment this repair have been used. Many of these operative methods require a second operation to remove the metalwork, and in addition can be associated with a failure rate of up to 30%. The ‘Surgilig™’ was originally designed for use in the revision of failed Weaver-Dunn procedures. However this study evaluates its use in the primary operation, reinforcing the autologous graft, in an attempt to reduce the failure rate. Data Collection And Analysis We prospectively followed up the Modified Weaver Dunn procedures using Surgilig™. The post-operative x-rays were reviewed at six weeks, three months and then six months to assess the radiological success of the procedure. Our patients were discharged at six months. Results We have performed this procedure in 11 patients. One of the 11 patients was excluded from the study as the Surgilig™ graft was used in addition to a hook plate. The remaining ten patients have all reached the six-month post-operative time with no incidence of radiological failure of the graft. After six months they were discharged from clinic follow-up as the coracoacromial graft had sufficient strength to no longer rely on the augment for mechanical stability of the joint. All 10 patients had a good clinical and radiological result. One patient even had inadvertent stress/ weight-bearing x-rays taken at six weeks, with no discernable detrimental effect to outcome. Conclusion Although a small study, these initial results for primary fixation of acromioclavicular joint disruption with Surgilig™ are extremely encouraging. The results suggest that Surgilig™ should continue to be used in its current role. As patient numbers increase, a follow-up study to evaluate these preliminary findings should be conducted.
Impact of peritoneal membrane transport on technique failure and patient survival in a population on automated peritoneal dialysis.

The peritoneal equilibration test (PET) is well established as a tool for classifying patients as low (L), low average (LA), high average (HA), or high (H) peritoneal transporters. We performed this retrospective 6 year cohort survey to evaluate the impact of different types of PET results on technique survival and patient survival on automated peritoneal dialysis (APD) therapy. From March 1992 to May 1998, 50 patients (20 men, 30 women) receiving APD were enrolled. The mean follow-up period was 25.2 +/- 9.2 months. Basic data and PET results of each patient at the initiation of APD therapy were retrospectively obtained for analysis. Adequacy of dialysis was estimated by measurement of total weekly urea clearance (Kt) normalized to total body water (V) and total weekly creatinine clearance (Ccr) per 1.73 m2 body surface area. The clinical outcomes evaluated were technique survival and patient survival. For statistical analyses we used the Kruskal-Wallis test, Friedman test, Kaplan-Meier life table analysis, and Cox's proportional hazards regression model. There were no differences in age, gender, prevalence of diabetes mellitus (DM), duration of APD, or the initial value of serum albumin between the four subgroups (H, HA, LA, and L). There were 11 (22%) deaths and 8 (16%) technique failures. The 2 year patient survival probability was significantly higher (100%) in the L subgroup than in the LA (62.6%), HA (48.4%), or H (46.2%) subgroups. Patients with DM had a lower patient survival rate than patients without DM; however, there was no statistical significance in technique survival rate between them. Diabetes mellitus (RR = 2.898) and the final albumin value (RR = 0.2099 per increase of 1 gm/dl) had a significant influence on patient survival. By stepwise regression analysis of final serum albumin levels, we found that patients with lower serum albumin values (< or = 3.0 gm/dl vs. >3.0 gm/dl) had a significantly lower probability of patient survival (p = 0.0156). We conclusively demonstrate four important findings in this work: 1) patients with H peritoneal transport had a lower probability of patient survival, but not a decreased rate of technique survival; 2) patients with L peritoneal transport can tolerate APD well; 3) there was no significant difference in technique survival rate between the different PET subgroups; and 4) DM and a lower serum albumin, implicating malnutrition, may contribute to the lower probability of patient survival among H peritoneal transporters.
Calcium signalling mediated by the α9 acetylcholine receptor in a cochlear cell line from the Immortomouse

1 We have investigated the characteristics of the α9 acetylcholine receptor (α9AChR) expressed in hair cell precursors in an immortalized cell line UB/OC‐2 developed from the organ of Corti of the transgenic H‐2Kb‐tsA58 mouse (the Immortomouse) using both calcium imaging and whole‐cell recording. 2 Ratiometric measurements of fura‐2 fluorescence revealed an increase of intracellular calcium concentration in cells when challenged with 10 μM ACh. The calcium increase was seen in 66 % of the cells grown at 39 °C in differentiated conditions. A smaller fraction (34 %) of cells grown at 33 °C in proliferative conditions responded. 3 Caffeine (10 mM) elevated cell calcium. In the absence of caffeine, the majority of imaged cells responded only once to ACh. A small proportion (< 2 % of the total) responded with an increase in intracellular calcium to multiple ACh presentations. Pretreatment with caffeine inhibited all calcium responses to ACh. 4 In whole‐cell tight‐seal recordings 10 μM ACh activated an inward, non‐selective cation current. The reversal potential of the ACh‐activated inward current was dependent on the extracellular calcium concentration with an estimated PCa/PNa of 80 for the α9 receptor at physiological calcium levels. 5 The data indicate that ACh activates a calcium‐permeable channel α9AChR in UB/OC‐2 cells and that the channel has a significantly higher calcium permeability than other AChRs. The results indicate that the α9AChR may be able to elevate intracellular calcium levels in hair cells both directly and via store release.
Counteraction by repetitive daily exposure to static magnetism against sustained blockade of N‐methyl‐D‐aspartate receptor channels in cultured rat hippocampal neurons

In rat hippocampal neurons cultured with the antagonist for N‐methyl‐D‐aspartate (NMDA) receptors dizocilpine (MK‐801) for 8 days in vitro (DIV), a significant decrease was seen in the expression of microtubule‐associated protein‐2 (MAP‐2) as well as mRNA for both brain‐derived neurotrophic factor (BDNF) and growth‐associated protein‐43 (GAP‐43), in addition to decreased viability. MK‐801 not only decreased the expression of the NR1 subunit of NMDA receptors but also increased NR2A expression, without affecting NR2B expression. Repetitive daily exposure to static magnetic fields at 100 mT for 15 min led to a decrease in the expression of MAP‐2, without significantly affecting cell viability or the expression of neuronal nuclei (NeuN) and GAP‐43. However, the repetitive magnetism prevented decreases in both BDNF mRNA and MAP‐2 and additionally increased the expression of NR2A subunit, without altering NR1 expression in neurons cultured in the presence of MK‐801. Repetitive magnetism was also effective in preventing the decrease by MK‐801 in the ability of NMDA to increase intracellular free Ca2+ ions, without affecting the decrease in the maximal response. These results suggest that repetitive magnetism may at least in part counteract the neurotoxicity of MK‐801 through modulation of the expression of particular NMDA receptor subunits in cultured rat hippocampal neurons. © 2005 Wiley‐Liss, Inc.
Self-management improvement program combined with community involvement in Thai hypertensive population: an action research.

OBJECTIVE To investigate the effectiveness of a program that utilizes community involvement to improve the self-management strategies among people living with hypertension. MATERIAL AND METHOD Forty-four subjects, aged 35 to 59-year-old, with hypertension in Nakhon Pathom Province, Thailand, were randomly allocated to either an experimental group (n = 22) or a control group (n = 20). The experimental group attended a program to improve self-management methods based on social cognitive theory (SCT). The program lasted 12 weeks, consisted of 1 1/2 hours meeting once a week, including group meetings and home visit monitoring. Mann-Whitney U test and Friedman test were employed to analyze the program's effectiveness. RESULTS After the program, the mean rank of the perceived self-efficacy for the self-management strategies was statistically different between the two groups (p = 0.023). In the experimental group, after the twelve week, the mean rank of perceived self-efficacy and outcome expectancy increased and diastolic blood pressure decreased after the eight week. CONCLUSION The program applied social cognitive theory (SCT) to promote self-management techniques, increased the health promoting behavior among hypertensive people.
Impact of Smooth Torque Control on the Efficiency of a High-Speed Automotive Switched Reluctance Drive

This paper examines the efficiency performance of an automotive-size high-speed switched reluctance drive. It investigates the impact of a smooth torque control algorithm on the efficiency and losses in the drive. In automotive drives, the application of a dedicated algorithm for torque ripple reduction at low to medium speed is indispensable to avoid excitation of mechanical resonances in the drive train. The predictive direct instantaneous torque control method is compared with efficiency optimized hysteresis current control in terms of efficiency. Dynamic finite-element loss analysis is employed to investigate the source of the efficiency deviation and the results are verified by measurements. The study shows that the requirement for smooth torque leads to a decrease in the drives efficiency and altered loss distribution. The efficiency map comparison reveals that the efficiency degradation amounts to 4–9% for this particular drive.
NAIP Toolkit for Malabo Domestication: Economic Modeling of Agricultural Growth and Investment Strategy Case Study of Kenya

The Malabo Agenda on Accelerated Agricultural Growth and Transformation has brought technical challengesto the development of agricultural strategiesby expanding the number of commitments and goalsunder the Comprehensive Africa Agriculture Development Programme.In this paper, we describe and apply an economic modeling framework that wasdeveloped to identify the agricultural investment priority areas for a country and to define milestones to track its progress towards the Malabo goals. The framework consists ofa three-layer simulation model that aimstocapturemultiple Malabo commitments and goals. First, the agricultural productivity analysis uses the stochastic meta-frontier technique to assess opportunities to increase agricultural productivity. Second, the economywide analysis uses an agricultural and investment focused computable general equilibrium model to capture the Malabo goalson agricultural growth, intra-Africantrade of agricultural commodities, and public and private agricultural investments.Third, the microeconomic analysis builds upon statistical economic modeling to allow direct measurement and simulation of the Malabo goals on poverty and hunger. The modeling framework is applied to Kenya using the most recent data.TheMalabo Agenda simulation results indicate that Kenyaâ€™s current nonagriculture-led growth isnot sufficient to achieving the Malabo overarching goals on poverty and hunger. Agriculture-led growthcomplemented by extendedsocial assistanceis more likely to close the income growth and inequality gaps and contribute to achieving the multiple Malabo commitments and goals by 2025.
Dengue and chikungunya in travelers: recent updates

Purpose of review Dengue virus (DENV) and chikungunya virus (CHIKV) cause significant morbidity in many world regions and their epidemiology, pathogenesis, vector issues, and control and prevention continue to fascinate researchers. This review focuses on the progress in these areas in the past 2 years. Recent findings Recent studies have highlighted the features of the epidemiology of DENV and CHIKV in Africa, some places of transmission being detected through travelers as sentinels. Autochthonous transmission of both viruses has been documented in France, raising concern regarding the potential for outbreaks where a competent vector, Aedes albopictus, is present. Some aspects of immune response following DENV and CHIKV infections have been elucidated. New diagnostic techniques for DENV have been explored as well as treatment for CHIKV. Research on Wolbachia as a means of biologic control of mosquito-borne infections including DENV and CHIKV has made significant progress. Summary These studies further our understanding of the evolving DENV and CHIKV epidemiology and potential transmission in nonendemic regions, and can contribute to the assessment of travelers. The new information on immunological responses to these viruses influences the vaccine development. Risk factors for severe disease and new therapeutic options could improve current treatment. Finally, research on Wolbachia holds promise in these two important vector-borne viral infections.
Systemic Treatment of Adrenocortical Carcinoma in Children: Data from the German GPOH-MET 97 Trial

Abstract Background: Adrenocortical cancer (ACC) in childhood is a rare disease with poor prognosis. Complete surgical resection, systemic chemotherapy, and mitotane therapy are important curative treatment options for patients with advanced-stage tumors. Since 1997, pediatric ACC patients in Germany have been treated according to the non-randomized, single arm study GPOH-MET-97. Patients and methods: Data regarding disease course, treatment, and survival rates of 60 patients (age 0.24–17.8 years) with ACC treated according to the GPOH-MET-97 protocol were collected and analyzed to determine outcome, with a focus on examining the effectiveness of mitotane therapy. Results: Among all patients, event-free survival and overall survival were found to be 43.3% and 64.8%, respectively. Chemotherapy with VCR, IFO, ADR, CARBO, and VP16 had been provided to 34 patients (56.6%) in different settings (neoadjuvant, adjuvant, and salvage) and mitotane therapy to 32 patients (53.3%). Duration of mitotane treatment longer than 6 months and mitotane levels greater than 14 mg/l were found to be associated with significantly better survival. Local relapse was found to be associated with a worse prognosis compared to distant metastasis only. Conclusions: Systemic chemotherapy and mitotane therapy are important therapeutic options in the treatment of advanced pediatric ACC patients. Neoadjuvant therapy should be considered for patients with primarily incomplete resectable or inoperable tumors, and tumor spillage is an indication for adjuvant chemo- and mitotane therapy. All pediatric ACC patients should be treated in pediatric oncological centers according to a consistent protocol in a highly interdisciplinary setting.
A fast method for saliency detection by back-propagating a convolutional neural network and clamping its partial outputs

In this paper, we propose a fast deep learning method for object saliency detection using convolutional neural networks. In our approach, we use a gradient descent method to iteratively modify the input images based on the pixel-wise gradients to reduce a pre-defined cost function, which is defined to measure the class-specific objectness and clamp the class-irrelevant outputs to maintain image background. The pixel-wise gradients can be efficiently computed using the back-propagation algorithm. We further apply SLIC superpixels and LAB color based low level saliency features to smooth and refine the gradients. Our methods are quite computationally efficient, much faster than other state-of-the-art deep learning based saliency methods. Experimental results on two benchmark tasks, namely Pascal VOC 2012 and MSRA10k, have shown that our proposed methods can generate high-quality salience maps, at least comparable with many slow and complicated deep learning methods. Comparing with the pure low-level methods, our approach excels in handling many difficult images, which contain complex background, highly-variable salient objects, multiple objects, and/or very small salient objects.
Chemokines regulate T cell adherence to recombinant adhesion molecules and extracellular matrix proteins.

Chemokines are a family of structurally related, low m.w. proteins that regulate leukocyte migration both in vitro and in vivo. By virtue of their target cell specificity, chemokines have the potential to selectively recruit leukocyte subpopulations into sites of inflammation during the genesis of an immune response. Chemokines have been shown to induce leukocyte adhesion to endothelium, to facilitate trans-endothelial passage, and to direct cell migration along a protein gradient (chemotaxis). The chemokines (macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and IFN-inducible protein-10) have recently been reported to be chemotactic for T cells. We have investigated the potential activity of these proteins in regulation of T cell adhesion. These chemokines induce T cell adhesion to purified, recombinant human adhesion molecules (rhICAM-1, rhVCAM-1) and to ECM proteins: fibronectin, collagen, and laminin. The chemokine-induced adhesion process occurs rapidly, is dose-dependent, and appears to be mediated via beta 1 and beta 2 integrins. The enhanced T cell adhesion is not associated with an increased surface expression of adhesion proteins, suggesting that chemokines stimulate the development of a high affinity state in the integrin molecules. Our findings provide in vitro evidence of a critical role for chemokines in T cell adhesion to endothelial adhesion molecules and ECM proteins, thereby promoting haptotactic migration of T cells to sites of inflammation in vivo.
Adoptive behaviors of farmers after training and their subsequent diffusive behaviors in Uasin Gishu County, Kenya.

This study focused on Kenyan farmers in the Moiben area who participated in three agricultural seminars at Twiga demonstration farm. The problem of interest was the need for increased dissemination of improved agricultural practices to enhance production and processing of crops related to food security and socio-economic well-being. The study investigated associations between adoptive behaviors of participants and their subsequent behavior related to diffusing improved practices to others. Data was collected using a demographic questionnaire and two structured interview schedules. Correlational analysis was conducted on post-training behavior variables, using Kendall’s tau calculations. The study found that farmers across the samples who exhibited higher levels of adoption of workshop-recommended innovations also had a moderate to strong likelihood of showing correspondingly higher levels of diffusion-related behavior. It was concluded that these findings align well with Rogers’ (2003) discussion of change-agent credibility, and also with Bandura’s (2006) work on social modeling and perceived self-efficacy. It was recommended that offering community-based agricultural seminars such as those in this study be continued and expanded, as an important component in a pluralistic model of agricultural extension methodology for Sub-Saharan Africa. It was further recommended that farmers who adopt improved practices learned in training be identified specifically for further interventions related to implementation and diffusion of agricultural innovations.
A class of gyrB mutants, substantially unaffected in DNA topology, suppresses the Escherichia coli K12 fts Z84 mutation

Previous work in our laboratory suggested that DNA topology could be implicated in the regulation of the division gene ftsZ. To settle this question, we have selected and characterized mutants in the gyrB gene able to phenotypically suppress the defects of the ftsZ84 mutation. No strict correlation was found between the degree of plasmid DNA relaxation and the level of suppression of the thermosensitivity of the ftsZ84 strain. Interestingly, the class of mutants that shows maximal suppression is substantially unaffected in DNA topology. In addition, the amount of ffsZ‐specific mRNA in this class of mutants is comparable to that present in the ftsZ84 strain. These results hint that the ability of these gyrB mutants to correct the effects of the ftsZ84 mutation is largely unrelated to the function of the GyrB (as a part of DNA gyrase) in the control of DNA superhelicity and suggest hitherto unsuspected interaction between the ftsZ and gyrB gene products.
Anti-bovine herpesvirus and anti-bovine viral diarrhea virus antibody responses in pregnant Holstein dairy cattle following administration of a multivalent killed virus vaccine.

OBJECTIVE To determine the effect of a commercially available multivalent killed virus vaccine on serum neutralizing (SN) and colostrum neutralizing (CN) antibodies against bovine herpesvirus (BHV) type 1 and bovine viral diarrhea virus (BVDV) types 1 and 2 in pregnant dairy cattle. ANIMALS 49 Holstein dairy cattle. PROCEDURES :25 cattle were vaccinated (IM injection) at least 60 days prior to calving (ie, at the end of the lactation period or according to the expected calving date for heifers) and again 5 weeks later. The remaining 24 cattle were not vaccinated (control group). Titers of SN antibodies were measured at the 5-week time point. Titers of SN and CN antibodies were measured at parturition. RESULTS 5 weeks after initial vaccination, titers of SN antibodies against BHV-1 and BVDV types 1 and 2 were 1:512, 1:128, and 1:2,048, respectively, in vaccinates and 1:64, 1:128, and 1:64, respectively, in unvaccinated controls. Equivalent SN antibody titers at parturition were 1:256, 1:64, and 1:512, respectively, in vaccinates and 1:128, 1:128, and 1:64, respectively, in controls. Median titers of CN antibodies against BHV-1 and BVDV types 1 and 2 were 1:1,280, 1:10,240, and 1:20,480, respectively, in vaccinates and 1:80, 1:1,280, and 1:2,560, respectively, in controls. CONCLUSIONS AND CLINICAL RELEVANCE Titers of antibodies against viral respiratory pathogens were significantly enhanced in both serum (BHV-1 and BVDV type 2) and colostrum (BHV-1 and BVDV types 1 and 2) in cattle receiving a killed virus vaccine (with no adverse reactions) before parturition. To maximize protection of bovine neonates, this method of vaccination should be considered.