Miracle-dz/UniFAR-FTUs huggingface dataset:
How Much Inequality Is Fair?: Mathematical Principles of a Moral, Optimal, and Stable Capitalist Society

Many in the United States feel that the nation’s current level of economic inequality is unfair and that capitalism is not working for 90% of the population. Yet some inequality is inevitable. The question is: What level of inequality is fair? Mainstream economics has offered little guidance on fairness and the ideal distribution of income. Political philosophy, meanwhile, has much to say about fairness yet relies on qualitative theories that cannot be verified by empirical data. To address inequality, we need to know what the goal is—and for this, we need a quantitative, testable theory of fairness for free-market capitalism. How Much Inequality Is Fair? synthesizes concepts from economics, political philosophy, game theory, information theory, statistical mechanics, and systems engineering into a mathematical framework for a fair free-market society. The key to this framework is the insight that maximizing fairness means maximizing entropy, which makes it possible to determine the fairest possible level of pay inequality. The framework therefore provides a moral justification for capitalism in mathematical terms. Venkat Venkatasubramanian also compares his theory’s predictions to actual inequality data from various countries—showing, for instance, that Scandinavia has near-ideal fairness, while the United States is markedly unfair—and discusses the theory’s implications for tax policy, social programs, and executive compensation.
Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma

Liver cancer is the one of most common types of cancer and the 2nd cause of cancer-associated mortalities worldwide. Establishing appropriate animal models of liver cancer is essential for basic and translational studies. The present study evaluated the effects of the combined use of alcohol with a conventional chemical-induced mouse liver cancer model. The treatment of alcohol/diethylnitrosamine (DEN)/carbon tetrachloride (CCl4) in the mice of experimental groups resulted in a series of pathological changes in the liver. Liver inflammation, fibrosis, cirrhosis and hepatocellular carcinoma were identified, and this method used less time (1–5 months) for inducement compared with the conventional chemical-induced method alone. In addition, murine α-fetoprotein (mAFP) was expressed throughout and ultrastructural features met the criteria for liver cancer. Fatty degeneration of pancreas, reduced blood glucose levels, and increased spleen weight were observed. These results indicated that an AFP-secreting hepatocellular carcinoma model of BALB/c mouse was successfully developed. The disease process and morphological changes met the criterion of the liver cancer process. Therefore the model developed in the present study may be an ideal animal model for studying the occurrence and development of liver cancer.
Entrepreneurship research in Latin America: a literature review

Purpose The purpose of this paper is to focus on the state of entrepreneurship research in the Latin American context, with special emphasis on international entrepreneurship research developed in this region. Therefore, the aim and contribution are to identify the main themes in the literature about entrepreneurship and show the evolution of entrepreneurship research in Latin America to stimulate the research and provide future research lines. Design/methodology/approach The methodology is based in a systematic literature review, using 128 articles published between 2002 and 2018, in scientific journals in the region according to SCImago Journal & Country Rank. Findings The results show the evolution through the journals, authors, topics and methodologies used by the researchers. It is emphasized that there is a very low level of research in international entrepreneurship in Latin America. This result is coherent with higher levels of entrepreneurship in Latin American countries but very few oriented to international markets. This is one of the challenges considering the importance of this field. Originality/value Entrepreneurship is a field of study that has grown throughout history. Even so, in the Latin American context, research published in high impact journals is limited. This paper is the first systematic literature review and thematic analysis of research on the field of entrepreneurship in the Latin American context. In this way, it serves as encouragement for future research, providing possibilities and challenges within the field of study.
Benefits of Real-Time Pricing and Rooftop Solar PV Generation: Explorations Using Swedish Micro-Data

Previous empirical literature on residential dynamic pricing for the Nordic market has questioned whether households will in fact appropriately respond, in view of the low price variability and price responsiveness in the Swedish setting. Household demand response is an issue of some importance in view of increasingly smart grids in which high shares of renewable supply are being promoted partly in view of these possibilities. In addition, an important development in the Nordic market relates to increasing thrust on household PV panels. In view of the interaction between RTP-driven and PV generation-driven load changes, an analysis of the combined effects in relation to system timing is important to understand, not least because this can affect the nature of benefits to households and the electric grid. Using a unique and very detailed dataset on household electricity consumption, in combination with simulated solar panel micro-generation data, these aspects are explored in an empirical framework similar to that used in the prior literature. Our findings indicate that even with minimal price responsiveness, household response to dynamic pricing can lead to load changes with sizeable benefits. In addition, the introduction of PV panels, contrary to what may be assumed at a first glance, appear to be beneficial to the electric grid, largely due to the time pattern of winter PV generation. Overall, our empirical findings provide tentative evidence to indicate that RTP, by incentivizing households to provide demand response at appropriate times, can aid in integration of renewables.
Uncoupling the Effects of Energy Expenditure and Energy Intake: Appetite Response to Short-term Energy Deficit Induced by Meal Omission and Physical Activity

The effects of two methods of inducing an acute energy deficit (exercise and a low-energy breakfast) on appetite were investigated in 11 healthy females, all of whom were regular exercisers and regular breakfast eaters. There were four experimental days: with exercise and a high-energy (500 kcal) breakfast (EHB), exercise and a low-energy (64 kcal) breakfast (ELB), no exercise and a high-energy breakfast (NEHB) and no exercise and a low-energy breakfast (NELB). Hunger and moods were monitored each hour from 8 a. m. until 5 p.m. Energy and macronutrient intake were measured during an ad libitum lunch test meal 4 h after the exercise and breakfast. Heart rate was continuously monitored using the Polar sport tester. The low-energy breakfasts (ELB and NELB) led to increased hunger during the morning and an increase in energy intake at lunch compared with the high-energy breakfasts. Subjects also experienced significantly more food cravings after LBs than after HBs. Exercise failed to have any significant effect on these variables. Thus, two methods of inducing a short-term energy deficit had markedly different effects on appetite. The low-energy breakfast presumably fails to generate the inhibitory satiety signals induced by the 500 kcal breakfast, whereas the metabolic effects of an exercise session failed to generate excitatory signals to hunger and food intake.
Identification of risk factors for stone recurrence after endoscopic treatment of bile duct stones

Recurrence of bile duct stones after endoscopic stone removal has been reported ranging from 4 to 24%. The risk of late complications such as stone recurrence is an important issue, especially for relatively young, otherwise healthy, patients with many years of future exposure time. The risk factors true recurrence of bile duct stones after endoscopic sphincterotomy (EST) and stone clearance are suboptimally defined. If patients at significant risk for stone recurrence could be identified, closer follow-up, earlier intervention, and possible preventive measures could theoretically decrease stone recurrence and late complications. The majority of patients with common bile duct stone who have EST and stone clearance will have no further biliary events during the remainder of their life. Whether identifying risk factors for recurrence can improve outcomes by prophylactic treatments or earlier interventions needs further prospective study.
Unusual Observations in the Wear-Out of High-Purity Aluminum Wire Bonds Under Extended Range Passive Thermal Cycling

This paper reports on the reliability of ultrasonically wedge-bonded 99.99% (4N) and 99.999% (5N) pure aluminum wires under different passive thermal cycling ranges, namely, -40°C to 190°C, -60°C to 170°C, -35°C to 145 °C, and -55°C to 125°C. The rate of bond strength degradation during cycling was found to be more rapid in the wire bonds subjected to lower peak temperatures (Tjmax) and lower temperature ranges (ΔT) for both wire types. This observed effect of ΔT cannot be described by the commonly accepted empirical relationships based on damage accumulation, such as the Coffin-Manson law. In addition, the 4N wire bonds were found to degrade more rapidly than the 5N bonds under the cycling ranges investigated. Microstructural characterization and nanoindentation of the bond interfaces indicated differences in microstructural restoration in wires subjected to the different cycling ranges. These differences have been attributed to annealing phenomena occurring in the wires during the high-temperature phase of cycling, which are believed to remove some of the damage accumulated during the low-temperature phase. A model is proposed for the prediction of wire bond wear-out rate, which incorporates both damage accumulation and damage removal mechanisms. We conclude that the rate of annealing during cycling varies exponentially with temperature; the annealing effects which occur can reduce damage accumulation and therefore influence wire bond reliability.
Dissociable Neural Effects of Task Order Control and Task Set Maintenance during Dual-task Processing

The functional relevance of the lateral prefrontal cortex (lPFC) for the ability to process two tasks simultaneously has been debated extensively in previous studies that employed functional magnetic resonance imaging (fMRI) to investigate the neural correlates of dual-task processing. In the present fMRI study, we shed new light on this debate by directly comparing the lPFC activity changes for two cognitive functions commonly associated with dual-task performance: task order control and task set maintenance. We manipulated both functions in a 2 2 integrated parametric design. The fMRI data revealed a functional-neuroanatomical dissociation for the lPFC. Regions surrounding the inferior frontal sulcus and the middle frontal gyrus were exclusively associated with task order control but not with increased demands on task set maintenance during dual-task processing. The only lPFC region associated with task set maintenance was located in the left anterior insula. Outside the lPFC, we found dissociable regions for task order control and task set maintenance bilaterally in the premotor cortices with more rostral premotor activity for task order control and more caudal premotor activity for task set maintenance. In addition, task order control activated the intraparietal sulci bilaterally. Our data clearly suggest that task order control is a separable cognitive mechanism in dual-task situations that is related to activity changes in the lPFC and that can be dissociated from task set maintenance.
Older women nurses: health, ageing concerns and self-care strategies.

AIM This paper is a report of a study of the health and ageing concerns and self-care strategies of older female Registered Nurses currently working in direct care-giving roles in acute public hospitals and community facilities. BACKGROUND Nursing is a rapidly ageing, and female-dominated workforce. However, despite the ageing of the nursing workforce, little is known about the needs and health concerns of older nurses. METHOD A feminist perspective was used and 12 female Registered Nurses aged 40-60 years, employed in various acute hospital and community health settings in Australia took part in qualitative interviews in late 2004. Narratives were audio taped, transcribed and analysed thematically. FINDINGS Two major themes were identified. The first theme -Aches and pains of ageing- had four subthemes: Neglecting self: 'You don't think of yourself first'; Physical changes: 'The body is wearing out'; Living with pain: 'You just work around it'; and Tiredness: 'I'm just tired all the time'. The second theme -Evolving lifestyles: works in progress - had three subthemes: The power of exercise: 'I feel great.and I'm enjoying life'; Healthy eating: 'Low fat, lots of fruit and veg, little processed food'; and Adapting to ageing: 'I think it's quite a good time of life'. CONCLUSION Further research is needed to explore the need for protective work practices and promoting healthy lifestyle practices for ageing nurses. Managers need to recognize the changing health needs of older clinical nurses and offer, for example, flexible rostering and tailored exercise programmes to promote their health.
Effect of immunization against the alpha N (alphaN) and alpha C (alphaC) peptides of the alpha43 subunit of inhibin on antral follicular growth and atresia and the patterns of gonadotrophin secretion in ewes.

The aims of this study were to investigate the role of inhibin in the distribution of healthy and atretic antral follicles and the secretion patterns of gonadotrophins. Ewes were actively immunized against either alphaN or alphaC of the inhibin alpha subunit with a primary injection and three booster injections. The control ewes received adjuvant only. The ovaries were removed either before or at 24 h after hCG administration in a synchronized follicular phase 48 h after removal of intravaginal progesterone pessaries. Morphological observations were made on every fifth section of the complete ovary (one per ewe) stained with haematoxylin and eosin. The mean number of corpora lutea observed per ewe with corpora lutea was not significantly different in ewes immunized against alphaN (2.4; alphaN-immunized ewes) or alphaC (2.6; alphaC-immunized ewes), and control (2.4) ewes, although some corpora lutea appeared cystic in the immunized ovaries. Compared with luteal phase concentrations, mean basal FSH concentrations in the early follicular phase were significantly increased in the alphaC-immunized ewes, similar in alphaN-immunized ewes and reduced in control ewes. No differences were observed in any of the LH parameters. Before hCG treatment, healthy antral follicles > 1 mm in diameter were not observed in any of the 52 follicles in the aC-immunized ewes and were observed in one of 37 follicles from alphaN-immunized ewes compared with 19 of 28 follicles in control ewes (P < 0.0001). For healthy antral follicles < 1 mm in diameter, there were 72 of 85 follicles in the alphaC-immunized ewes, 79 of 81 follicles in the alphaN-immunized ewes and 81 of 82 follicles in the control ewes. Similar results were obtained in healthy antral follicles < 1 mm in diameter at 24 h after hCG administration. In contrast to the control ewes, no healthy preovulatory follicles (> 6 mm in diameter) were observed in alphaN- and alphaC-immunized ewes either before or 24 h after hCG administration. Two newly formed corpora lutea from alphaC-immunized ovaries contained retained oocytes compared with none in control and alphaN-immunized ovaries. In conclusion, immunization against alphaN and alphaC may result in disruption of the normal processes of antral follicular growth and maturation independent of the concentrations of FSH and LH.
E47 Controls the Developmental Integrity and Cell Cycle Quiescence of Multipotential Hematopoietic Progenitors1

Little is known about the transcriptional regulators that control the proliferation of multipotent bone marrow progenitors. Understanding the mechanisms that restrict proliferation is of significant interest since the loss of cell cycle integrity can be associated with hematopoietic exhaustion, bone marrow failure, or even oncogenic transformation. Herein, we show that multipotent LSKs (lineage−Scahighc-kit+) from E47-deficient mice exhibit a striking hyperproliferation associated with a loss of cell cycle quiescence and increased susceptibility to in vivo challenge with a mitotoxic drug. Total LSKs contain long-term self-renewing hematopoietic stem cells and downstream multipotential progenitors (MPPs) that possess very limited or no self-renewal ability. Within total LSKs, we found specific developmental and functional deficits in the MPP subset. E47 knockout mice have grossly normal numbers of self-renewing hematopoietic stem cells but a 50–70% reduction in nonrenewing MPPs and downstream lineage-restricted populations. The residual MPPs in E47 knockout mice fail to fully up-regulate flk2 or initiate V(D)J recombination, hallmarks of normal lymphoid lineage progression. Consistent with the loss of normal cell cycle restraints, we show that E47-deficient LSKs have a 50% decrease in p21, a cell cycle inhibitor and known regulator of LSK proliferation. Moreover, enforced expression studies identify p21 as an E47 target gene in primary bone marrow LSKs. Thus, E47 appears to regulate the developmental and functional integrity of early hematopoietic subsets in part through effects on p21-mediated cell cycle quiescence.
‘In the driving seat’, or reluctant passengers? Employer engagement in qualifications development: some evidence from two recent 14–19 qualification reforms in England

Abstract Vocational education and training has received substantial policy attention in recent years that is paired with the ambition for the UK to become a leading country for jobs, productivity and skills. Recommendations from two recent reviews form the basis for substantial policy reforms within the 14–19 curriculum. Discourse of employer engagement has been a persistent theme in the reform agenda and the pressure on employers to engage has been intensified. Recent policy documents, particularly within the 14–19 phase, carry the exhortation for employers to jump ‘in the driving seat’ when it comes to qualifications development. This article examines employer engagement in two recent reforms; Diplomas (2005–2010) and 16–19 Study Programmes (2011-present). It reflects on the extent to which employers are able to fulfil policy expectations and what lessons could be learnt from previous attempts to engage them in qualification design and delivery. The article concludes that employer engagement within the 14–19 curriculum continues to be encouraged. The level of employer engagement, however, must be carefully matched to the expertise, experience, capacity and motivation of employers. It is argued that lessons should be learnt from previous experiences of qualifications development to avoid employers abandoning the journey completely.
What Influences People’s Tradeoff Decisions Between CO2 Emissions and Travel Time? An Experiment With Anchors and Normative Messages

One of the today’s greatest challenges is to adjust our behavior so that we can avoid a major climate disaster. To do so, we must make sacrifices for the sake of the environment. The study reported here investigates how anchors (extrinsic motivational-free information) and normative messages (extrinsic motivational information) influence people’s tradeoffs between travel time and carbon dioxide (CO2) emissions in the context of car travel and whether any interactions with environmental concern (an intrinsic motivational factor) can be observed. In this study, people received either a CO2, health or no normative message together with either a high anchor, a low anchor, or no anchor. People that received both a high anchor and a CO2 emission normative message were willing to travel for a longer time than those that only received a high anchor. If a low anchor was presented, no differences in willingness to travel for a longer time were found between the three different conditions of normative message groups, i.e., CO2 normative message, health normative message, or no normative message. People with higher concern for the environment were found to be willing to travel for a longer time than those with lower concern for the environment. Further, this effect was strongest when a high anchor was presented. These results suggest that anchors and normative messages are among the many factors that can influence people’s tradeoffs between CO2 emission and travel time, and that various factors may have to be combined to increase their influence over pro-environmental behavior and decisions.
Antibiotic-Resistant Cell-Detaching Escherichia coli Strains from Nigerian Children

ABSTRACT The properties of 23 cell-detaching Escherichia coli strains that were isolated from stool specimens in Nigeria are described. Common properties of the strains included the presence of genes encoding α-hemolysin (100%), pyelonephritis-associated pili (100%), and cytotoxic necrotizing factor 1 (70%) as well as lactose negativity (70%) and multiple antibiotic resistance (74%). Antibiotic resistance was shown in most cases to be transferable and associated with the presence of class 1 integrons. Phenotypic properties and pulsed-field gel electrophoresis analysis demonstrated that the majority of the strains, particularly multiply resistant, lactose-negative O4:H40 strains, were closely related. Multiply-resistant cell-detaching E. coli strains may represent an important reservoir for antibiotic resistance genes.
Dynamic Autocorrelation and International Portfolio Allocation

We explore the relevance of dynamic autocorrelation in modeling expected returns and allocating funds between developed and emerging stock markets. Using stock market data for the US and Latin America, we find that autocorrelation in monthly returns vary with conditional volatility, implying some investors implement feedback trading strategies. Dynamic autocorrelation models fit the data considerably better than a conditional version of the zero-beta CAPM, while differences between models with an autoregressive term are modest. Investors can improve their portfolio optimization between developed and emerging stock markets by considering time-varying autocorrelation. The most drastic difference in portfolio performance is not due to allowing autocorrelation to vary over time, but realizing that stock returns are autocorrelated, especially in emerging stock markets.