Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduction Mammaplasty: A Review of Managed Care Medical Policy Coverage Criteria

Background: Insurance companies evaluate the medical necessity for breast reduction surgery based on internal company medical policies, but the correlation of insurance company criteria to the scientifically established indications for reduction mammaplasty has never been studied. The authors obtained 90 insurance company medical policies for reduction mammaplasty to determine whether the criteria on which coverage determinations are made are consistent with published data regarding the indications for this procedure. Methods: The authors reviewed the medical literature on reduction mammaplasty and identified what conclusions can reasonably be drawn from this literature on the common insurance criteria used to determine medical necessity for reduction mammaplasty. Conclusions based on the medical literature regarding volume of reduction, symptom presentation, conservative therapy, obesity, presence of bra strap grooving and intertrigo, and age at time of reduction were formulated, and these conclusions were compared with the criteria of 90 different health insurance reduction mammaplasty medical policies. Results: The authors were unable to identify any medical policies that could be supported in entirety by the medical literature and many that are completely unfounded based on the medical literature. Conclusions: Insurance company medical policy requirements with respect to reduction mammaplasty are, in many cases, arbitrary and without scientific basis. Requirements for a specific volume of reduction, a minimum age, a maximum body weight, and a trial of conservative therapy are required by the majority of managed care medical policies, even though scientific support for any of these requirements is not evident in the medical literature.
Augmentation: A process that acts to increase transmitter release at the frog neuromuscular junction.

1. End‐plate potentials (e.p.p.s) were recorded from frog neuromuscular junctions bathed in Ringer solution containing increased Mg and decreased Ca to reduce transmitter release. Conditioning and testing stimulation was applied to the nerve to study a previously uncharacterized process which acts to increase e.p.p. amplitudes. We will refer to this process as augmentation. 2. Following repetitive stimulation augmentation decayed approximately exponentially over most of its time course with a mean time constant of about 7 sec (range 4‐10 sec) which is intermediate in duration between the time constants for the decay of facilitation and potentiation. 3 . The magnitude of agumentation increased with the duration of the conditioning stimulation. Assuming a multiplicative relationship between augmentation and potentiation, values of the magnitude of augmentation ranged from 0‐3 to 0‐6 following 50 impulses at 20/sec to 0‐5‐7‐8 following 600 impulses at 20/sec. (An augmentation of 0‐3 and 7‐8 would increase e.p.p. amplitudes 1‐3 and 8‐8 times, respectively.) 4. The time constant characterizing the decay of augmentation remained relatively constant as the duration of the conditioning stimulation was increased. 5. Augmentation as well as facilitation and potentiation resulted from an increase in the number of quanta of transmitter released from the nerve terminal. 6. Augmentation decayed faster at higher temperatures with a mean temperature coefficient, Q10, of about 3‐8. The corresponding Q10 for the decay of potentiation was found to be about 2‐4. 7. It is concluded that augmentation can be a significant factor in increasing transmitter release and will therefore have to be accounted for when studying the effects of repetitive stimulation on the function of the nerve terminal or when formulating models of transmitter release.
Search for neutrinoless double-beta decay in 136Xe with EXO-200.

We report on a search for neutrinoless double-beta decay of 136Xe with EXO-200. No signal is observed for an exposure of 32.5 kg yr, with a background of ∼1.5×10(-3) kg(-1) yr(-1) keV(-1) in the ±1σ region of interest. This sets a lower limit on the half-life of the neutrinoless double-beta decay T(1/2)(0νββ)(136Xe)>1.6×10(25) yr (90% C.L.), corresponding to effective Majorana masses of less than 140-380 meV, depending on the matrix element calculation.
IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors

Endometriosis is a chronic, inflammatory disease characterized by the growth of endometrial tissue in aberrant locations outside the uterus. Neoangiogenesis or establishment of new blood supply is one of the fundamental requirements of endometriotic lesion survival in the peritoneal cavity. IL-17A is emerging as a potent angiogenic and proinflammatory cytokine involved in the pathophysiology of several chronic inflammatory diseases such as rheumatoid arthritis and psoriasis. However, sparse information is available in the context of endometriosis. In this study, we demonstrate the potential importance of IL-17A in the pathogenesis and pathophysiology of endometriosis. The data show a differential expression of IL-17A in human ectopic endometriotic lesions and matched eutopic endometrium from women with endometriosis. Importantly, surgical removal of lesions resulted in significantly reduced plasma IL-17A concentrations. Immunohistochemistry revealed localization of IL-17A primarily in the stroma of matched ectopic and eutopic tissue samples. In vitro stimulation of endometrial epithelial carcinoma cells, Ishikawa cells, and HUVECs with IL-17A revealed significant increase in angiogenic (vascular endothelial growth factor and IL-8), proinflammatory (IL-6 and IL-1β), and chemotactic cytokines (G-CSF, CXCL12, CXCL1, and CX3CL1). Furthermore, IL-17A promoted tubulogenesis of HUVECs plated on Matrigel in a dose-dependent manner. Thus, we provide the first evidence, to our knowledge, that endometriotic lesions produce IL-17A and that the removal of the lesion via laparoscopic surgery leads to the significant reduction in the systemic levels of IL-17A. Taken together, our data show a likely important role of IL-17A in promoting angiogenesis and proinflammatory environment in the peritoneal cavity for the establishment and maintenance of endometriosis lesions.
Dual-mode behavior of the complementary electric-LC resonators loaded on transmission line: Analysis and applications

This article presents an analysis of metamaterial resonators coupled with microstrip transmission line. The behavior of complementary electric-LC resonators loaded on a microstrip line is analyzed using the equivalent circuit model. In this paper, it is shown that a special type of these resonators show a dual-mode behavior when excited through the electromagnetic field around the microstrip transmission lines. The bandstop and bandpass configurations of these dual mode resonators loaded with microstrip lines are introduced and analyzed. Their potential applications are highlighted through designing a displacement sensor and a dual-mode bandpass filter prototypes.
Classification of daily and near-daily headaches

Primary chronic daily headache can be subdivided into transformed migraine, chronic tension-type headache, hemicrania continua, and new daily persistent headache. We proposed and tested criteria in 150 consecutive outpatients with chronic daily headache. Based on preliminary analysis, we revised the criteria for transformed migraine. Using the International Headache Society criteria, 43% of the patients could not be classified; using our old criteria, 25% could not be classified; however, using our new criteria, we were able to classify 100%. Seventy-eight percent had transformed migraine, 15.3% had chronic tension-type headache, and 6.7% had other headache disorders. NEUROLOGY 1996;47: 871-875
Retinoic acid induces cholinergic differentiation of cultured newborn rat sympathetic neurons

Many studies provide evidence that retinoic acid (RA), an endogenous derivative of vitamin A, plays a role in the development of the nervous system. We now report that RA controls the neurotransmitter phenotype of post‐mitotic rat sympathetic neurons in cell culture. RA added to the culture medium increased the specific activity of choline acetyltransferase (ChAT) and the level of acetylcholine (ACh). Concomitantly, RA reduced the specific activities of two catecholamine synthetic enzymes, tyrosine hydroxylase (TH) and dopamine β‐hydroxylase (DBH) and the level of norepinephrine (NE). After a 2 week treatment with 5 μM RA, ChAT was increased by 5–10 fold, whereas TH and DBH were decreased by 10–15 fold and 2–3 fold, respectively, as compared to sympathetic neurons grown in the absence of RA. The modulation of the activity of the three enzymes was dose‐dependent and followed a similar time course. The decrease of TH expression was demonstrated to be due to a decreased number of TH molecules. © 1993 Wiley‐Liss, Inc.
Varenicline versus bupropion SR or placebo for smoking cessation: a pooled analysis.

OBJECTIVES To evaluate varenicline's efficacy for smoking cessation versus bupropion SR and placebo and to explore whether factors typically predictive of abstinence influence varenicline's efficacy versus placebo, as measured by the week 9-12 continuous abstinence rate (CAR9-12). METHODS Smokers in 2 randomized, placebo-controlled trials received varenicline 1 mg BID (n=696), bupropion SR 150 mg BID (n=671), or placebo (n=685) for 12 weeks. Nontreatment followup lasted 40 weeks. RESULTS CAR(9-12) was greater for varenicline (44.0%) versus bupropion SR (29.7%; P<0.0001) and placebo (17.7%; P<0.0001). CAR(9-12) for varenicline versus placebo was not affected by age, gender, or nicotine dependence level. CONCLUSIONS Varenicline was more efficacious than bupropion SR or placebo. Varenicline's efficacy versus placebo was not influenced by factors predictive of abstinence.
Motivation, treatment engagement and psychosocial outcomes in outpatients with severe mental illness: a test of Self‐Determination Theory

Currently, it is unclear whether Self‐Determination Theory (SDT) applies to the mental health care of patients with severe mental illness (SMI). Therefore, the current study tested the process model of SDT in a sample of outpatients with SMI. Participants were 294 adult outpatients with a primary diagnosis of a psychotic disorder or a personality disorder and their clinicians (n = 57). Structural equation modelling was used to test the hypothesized relationships between autonomy support, perceived competence, types of motivation, treatment engagement, psychosocial functioning and quality of life at two time points and across the two diagnostic groups. The expected relations among the SDT variables were found, but additional direct paths between perceived competence and clinical outcomes were needed to obtain good model fit. The obtained process model was found to be stable across time and different diagnostic patient groups, and was able to explain 18% to 36% of variance in treatment engagement, psychosocial functioning and quality of life. It is concluded that SDT can be a useful basis for interventions in the mental health care for outpatients with SMI. Additional experimental research is needed to confirm the causality of the relations between the SDT constructs and their ability to influence treatment outcomes.
Identification of Immunodominant Epitopes on the Membrane Protein of the Severe Acute Respiratory Syndrome-Associated Coronavirus

ABSTRACT Similar to other coronaviruses, the membrane (M) protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is a major transmembrane glycoprotein with multiple biological functions. To date, limited information is available about its antigenic properties. In this study, we identified two major immunodominant epitopes on the M protein located in the extreme N-terminal region (residues 1 to 31) and the interior C-terminal region (residues 132 to 161), respectively, by Pepscan analyses against convalescent-phase sera from SARS patients and antisera from virus-immunized mice and rabbits. Synthetic peptides M1-31 derived from the N-terminal epitope and M132-161 derived from the C-terminal epitope were highly reactive with all of the convalescent-phase sera from 40 SARS patients but not with 30 control serum samples from healthy blood donors, suggesting their potential application for serologic diagnosis of SARS. We showed that both peptides (M1-31 and M132-161) were able to induce high titers of antibody responses in the immunized rabbits, highlighting their antigenicity and immunogenicity. These findings provide important information for developing SARS diagnostics and vaccines.
Detecting jumps and regime switches in international stock markets returns

This article explores seven international stock markets (DJIA, Euro STOXX 600, Russell 2000, Nikkei, NASDAQ, FTSE and Global Dow) in the quest for jumps and regime switches. The methodological framework borrows from the Markov-switching approach and the stochastic modelling literature based on Lévy processes. The econometric procedure is detailed in a two-step fashion. The data set covers the period from June 2004 to July 2014. The main results uncover changing market dynamics according to economic and/or financial phenomena (e.g., economic crises/growth, news events) with the occurrence of several episodes characterized by a high jump intensity. We advocate the use of such a jump-robust model modulated by a Markov chain to further study the dependence structure of financial time series.
Expectations of Competency: The Mismatch between Employers' and Graduates' Views of End-User Computing Skills Requirements in the Workplace

Four graduate-level positions were identified from advertisements placed in order to recruit graduates. The employers who placed these advertisements were interviewed, as were 21 students about to graduate from a university commerce programme. It was determined that the wording of the advertisements did not satisfactorily portray the requirements and intentions of the employers. Employers, unsure in many cases of how to request the skills they needed, assumed that graduates’ end-user computing skill would be at a level suitable for entry into the workplace. Students close to graduating, while accepting that computers would be a part of their daily work life, had no idea of the type of computing skills employers would expect.
An AAC Personnel Framework: Adults with Acquired Complex Communication Needs

A personnel framework designed to support people who rely on augmentative and alternative communication (AAC) because of acquired medical conditions and those who assist them is described. The roles of AAC finders, general practice clinicians, AAC intervention specialists, AAC facilitators, and AAC experts are summarized. These roles are described in detail for people with amyotrophic lateral sclerosis, brainstem impairment, and severe chronic aphasia. The personnel preparation needs for each of these support personnel groups are identified.
Report of the national workshop on internet voting: issues and research agenda

As use of the Internet in commerce, education and personal communication has become common, the question of Internet voting in local and national elections naturally arises. In addition to adding convenience and precision, some believe that Internet voting may reverse the historical and downward trend of voter turnout in the United States. For these reasons President Clinton issued a memorandum in December 1999 requesting that the National Science Foundation examine the feasibility of online (Internet) voting.
Microsatellite in the beta-tubulin gene of Toxoplasma gondii as a new genetic marker for use in direct screening of amniotic fluids

To examine the correlation between Toxoplasma gondii genotype and congenital human toxoplasmosis, the polymorphism of the microsatellite consisting of a dinucleotide (TG) repeat in the intron of the beta-tubulin gene was investigated by PCR. Thirty-four reference strains were studied, including 7 strains virulent in mice and 27 strains avirulent in mice. The seven virulent strains had a (TG)8 microsatellite, and the avirulent strains had a (TG)7 microsatellite. This confirms the dichotomy already observed for virulent and avirulent strains. Additionally, 37 samples of amniotic fluid from infected fetuses were tested. All of them had the (TG)7 microsatellite marker. This result confirms that most of the human cases of congenital toxoplasmosis are due to strains avirulent in mice. Nevertheless, their virulence in human fetuses was obvious, as numerous abnormalities were observed on ultrasonic examination. The new genetic marker is the first one directly used for typing T. gondii isolates without any bias due to cultivation of the parasite. This microsatellite marker is not sufficient to type the strains which are avirulent in mice; however, seeking more polymorphic microsatellites should be worthwhile to obtain new genetic markers for direct screening of biological samples.
Competitive stress can make the herbicide Roundup® more deadly to larval amphibians

Toxicity assessments on nontarget organisms have largely been addressed using short‐term, single‐species laboratory experiments. Although extremely helpful, these experiments inherently lack many pervasive ecological stressors found in nature. Though a substantial challenge, incorporating these ecological stressors in contaminant studies would shed light on potential synergistic effects. For the world's leading herbicide, glyphosate, we know little about how natural stressors affect the toxicity to nontarget organisms. To explore how the natural stress of competition might interact with a glyphosate‐based herbicide, we used outdoor mesocosms containing three tadpole species that were exposed to a factorial combination of three glyphosate concentrations (0, 1, 2, or 3 mg acid equivalent (a.e.)/L of the commercial formulation Roundup Original MAX®) and three tadpole densities (low, medium, or high). We found that increased tadpole density caused declines in tadpole growth, but also made the herbicide significantly more lethal to one species. Whereas the median lethal concentration (LC50) values were similar across all densities for gray treefrogs (Hyla versicolor; 1.7–2.3 mg a.e./L) and green frogs (Rana clamitans; 2.2–2.6 mg a.e./L), the LC50 values for bullfrogs (R. catesbeiana) were 2.1 to 2.2 mg a.e. /L at low and medium densities, but declined to 1.6 mg a.e. /L at high densities. The large decrease in amphibian survival with increased herbicide concentration was associated with increases in periphyton abundance. We also found evidence that temperature stratification lead to herbicide stratification in the water column, confirming the results of a previous study and raising important questions about exposure risk in natural systems. Environ. Toxicol. Chem. 2011;30:446–454. © 2010 SETAC
Conceptual framework for the implementation of interventions in the construction industry.

OBJECTIVES The objective of this study was to explore the necessary steps to define the implementation of interventions aimed at reducing physical work demands due to manual materials handling in the construction industry. METHODS A theoretical structured framework of six steps is outlined as a method for developing the implementation of interventions. In this framework, both the proposal for implementing the intervention measures and the context analysis are conditional. RESULTS Application of the framework in the development of the implementation of interventions to reduce the physical work demands for bricklayers and bricklayers' assistants has been presented. CONCLUSIONS The framework was found appropriate for defining implementation strategies and (ergonomic) measures in the construction industry.
Amino acid-based zwitterionic polymers: antifouling properties and low cytotoxicity

A group of five amino acid containing zwitterionic vinyl monomers, based on serine, lysine, ornithine, glutamic acid, and aspartic acid, respectively, were proposed and developed for potential antifouling applications. Their polymer brushes were grafted on gold chips by surface-initiated photoiniferter-mediated polymerization. We then compared their performance in resisting protein adsorption from full human serum and plasma. All five polymers can reduce protein adsorption by more than 90% compared to the unmodified gold. The ornithine-based and aspartic acid-based poly(methacrylamide) can most strongly resist protein adsorption from serum and plasma, compared to the other three. The ability of surfaces to suppress bacterial adhesion is another criterion in evaluating antifouling properties of materials. Our results show that the five polymer-grafted surfaces can significantly suppress Escherichia coli K12 adhesion to 99% compared to the bare gold surface. The zwitterionic structure of amino acids, with homogenously distributed and balanced positive and negative charges, is responsible for the outstanding antifouling properties. Considering multiple potential applications (e.g. medical devices and drug delivery) of the antifouling materials, we further systematically evaluated the cytotoxicity of both monomers and polymer nanogels for all five materials at various concentrations. Very low cytotoxicity was observed for all tested amino acid-based monomers and nanogels, which is comparable or even lower than the traditional and some newly developed antifouling materials, which might be related to the biomimetic nature of amino acids.
Processing of MIA protein during melanoma cell migration

MIA (melanoma inhibitory activity) protein, identified as a small 11 kDa protein highly expressed and secreted by malignant melanoma cells, plays an important functional role in melanoma development, progression and tumor cell invasion. Recent data describe a direct interaction of MIA protein with cell adhesion receptors integrin α4β1 and integrin α5β1 and extracellular matrix molecules. By modulating integrin activity MIA protein mediates detachment of melanoma cells from surrounding structures resulting in enhanced invasive and migratory potential. However, until today a detailed understanding of the processes of MIA function is missing. In this study, we show that after binding of MIA protein to integrin α5β1, MIA protein is internalized together with this cell adhesion receptor at the cell rear. This mechanism enables tumor cells to migrate in a defined direction as appropriate for invasion processes. Treatment of melanoma cells with PKC‐inhibitors strongly reduced internalization of MIA protein. Endocytosis is followed by dissociation of MIA–integrin complexes. In acidic vesicles MIA protein is degraded while integrins are recycled. Treatment of melanoma cells with MIA inhibitory peptides almost completely blocked the MIA protein uptake into cells. As MIA protein has a major contribution to the aggressive characteristics of malignant melanoma in particular to formation of metastasis, it is important to elucidate the MIA functional mechanism in tumor cells to find novel therapeutic strategies in the fight against skin cancer. © 2009 UICC
From Effort to Value

In the current studies, we addressed the development of effort-based object valuation. Four- and 6-year-olds invested either great or little effort in order to obtain attractive or unattractive rewards. Children were allowed to allocate these rewards to an unfamiliar recipient (dictator game). Investing great effort to obtain attractive rewards (a consonant situation) led 6-year-olds, but not 4-year-olds, to enhance the value of the rewards and thus distribute fewer of them to others. After investing effort to attain unattractive rewards (a dissonant situation), 6-year-olds cognitively reduced the dissonance between effort and reward quality by reappraising the value of the rewards and thus distributing fewer of them. In contrast, 4-year-olds reduced the dissonance behaviorally by discarding the rewards. These findings provide evidence for the emergence of an effort-value link and underline possible mechanisms underlying the primacy of cognitive versus behavioral solutions to dissonance reduction.