Miracle-dz/UniFAR-FTUs huggingface dataset:
Simultaneous PET-MRI Studies of the Concordance of Atrophy and Hypometabolism in Syndromic Variants of Alzheimer's Disease and Frontotemporal Dementia: An Extended Case Series.

BACKGROUND Simultaneous PET-MRI is used to compare patterns of cerebral hypometabolism and atrophy in six different dementia syndromes. OBJECTIVES The primary objective was to conduct an initial exploratory study regarding the concordance of atrophy and hypometabolism in syndromic variants of Alzheimer's disease (AD) and frontotemporal dementia (FTD). The secondary objective was to determine the effect of image analysis methods on determination of atrophy and hypometabolism. METHOD PET and MRI data were acquired simultaneously on 24 subjects with six variants of AD and FTD (n = 4 per group). Atrophy was rated visually and also quantified with measures of cortical thickness. Hypometabolism was rated visually and also quantified using atlas- and SPM-based approaches. Concordance was measured using weighted Cohen's kappa. RESULTS Atrophy-hypometabolism concordance differed markedly between patient groups; kappa scores ranged from 0.13 (nonfluent/agrammatic variant of primary progressive aphasia, nfvPPA) to 0.49 (posterior cortical variant of AD, PCA). Heterogeneity was also observed within groups; the confidence intervals of kappa scores ranging from 0-0.25 for PCA to 0.29-0.61 for nfvPPA. More widespread MRI and PET changes were identified using quantitative methods than on visual rating. CONCLUSION The marked differences in concordance identified in this initial study may reflect differences in the molecular pathologies underlying AD and FTD syndromic variants but also operational differences in the methods used to diagnose these syndromes. The superior ability of quantitative methodologies to detect changes on PET and MRI, if confirmed on larger cohorts, may favor their usage over qualitative visual inspection in future clinical diagnostic practice.
Intestinal Phase of Pancreatic Polypeptide Release: The Effect of Segmental Perfusion of the Small Intestine with Various Secretagogues

The purpose of this study was to examine the effect of various nutrients perfused selectively into isolated sections of the small intestine on the release of pancreatic polypeptide (PP). Six dogs were prepared with chronic gastric, duodenal, and three permanent intestinal fistulas (one distal to the ligament of Treitz, one in the terminal ileum, and one halfway between). After a 24-h fast, the duodenum was perfused for 45 min (200 mlh) via the duodenal limb with HC1 (30 mM), an amino acid solution (50 mM), or sodium oleate (NaO, 40 mM). In separate studies, the jejunal and ileal segments were isolated by inflating two balloon catheters via the intestinal fistula, and these segments were perfused as described earlier. Plasma PP, cholecystokinin (CCK)-33, and secretin levels were measured. Results of this study showed that the perfusion of all segments of the small intestine with amino acid caused a significant elevation of plasma PP levels. Perfusion of the duodenum and jejunum but not the ileum with a fatty acid resulted in a significant elevation of plasma levels of PP. Perfusion of HCl into any segment did not affect plasma levels of PP. This study shows that PP is released by the presence of nutrients in all segments of the small intestine, and that a PP elevation was always accompanied with a rise in plasma levels of CCK-33.
Pricing the implicit contracts in the Paris Club debt buybacks

In 2005, more than 20 billion dollars were bought back by Paris Club debtors: Russia USD 15 billion Poland USD 5.4 billion and Peru USD 1.5 billion. During the first half of 2006, more than USD 30 billion in buybacks was announced: Russia USD 22 billion, Algeria USD 8 billion dollars, Brazil USD 1.5 billion. The buybacks consisted of the prepayment of debts at par with no penalties. These transactions were carried out at a discount of more than 20% compared to their net present value. The total loss incurred by creditors in the three buybacks is estimated at more than USD 10 billion. This raises the question as to why the Paris Club creditors agreed to the buybacks voluntarily. It appears that these buybacks are the result of the exercise of specific contracts previously agreed with the debtors in the 1990s, without receiving any compensation for this and without assessing the consequences. These implicit contracts make it possible to formalise the respective interests for creditors and debtors. Their pricing requires the use of financial mathematics tools (derivatives) and stochastic models for interest rates (Vasicek), but applied in the Paris Club framework.
An epidemiological study of mental disorders in a 10-year cohort of young adults in Israel

Synopsis This is an overview of a two-phase epidemiological study of mental disorders among young adults in a ten-year birth cohort (1949–58) conducted in Israel. A sample of 4914 Israel-born offspring of Jewish immigrants was obtained by full probability sampling procedures and screened for caseness using psychometric symptom scales from the Psychiatric Epidemiology Research Interview (PERI). Those screened positive and almost a fifth of the negatives (N = 2741) were interviewed by psychiatrists using the Schedule for Affective Disorders and Schizophrenia, Israel version (SADS-I), in order to determine prevalence rates of specific disorders as defined by the Research Diagnostic Criteria (RDC). The completion rates for each interview phase were 94·5% and 90·7% respectively. Six-month prevalence rates are presented by gender, ethnic origin, and education. Approximately one-fifth of the birth cohort met current RDC criteria for a disorder at the definite level, excluding the RDC category of ‘other psychiatric disorder’. Generalized anxiety disorder and major depressive disorder were the most commonly found types. The striking findings centre on alcoholism and drug use disorder which were exceedingly rare, and the unusually similar rates of major depression for males and females. The results from this study are discussed in comparison with those obtained from other epidemiological studies.
Relationship of Usual Volume and Heavy Consumption to Risk of Alcohol-Related Injury: Racial/Ethnic Disparities in Four U.S. National Alcohol Surveys.

OBJECTIVE National population data on racial/ethnic disparities and risk of alcohol-related injury are scarce. Alcohol-related injury and drinking patterns are examined in a sample of respondents from four (1995, 2000, 2005, 2010) U.S. National Alcohol Surveys using risk function analysis. METHOD Self-reported consumption of 15,476 current drinkers was assessed as the average number of drinks consumed monthly and, separately, the frequency of consuming five or more drinks in a day (5+ days) in the last year. Alcohol-related injury was defined as drinking within 6 hours before the event. Risk curves were defined, separately for Whites, Blacks, and Hispanics, using fractional polynomial regression. RESULTS Risk was greatest for Hispanics to 110 drinks per month (3-4 drinks per day) and above 240 drinks per month, whereas risk was greatest for Whites between these levels. Blacks were at lower risk at all monthly volume levels when demographic and socioeconomic status characteristics were controlled for. Whites had the highest risk of an alcohol-related injury based on 5+ drinking days at all levels up to nearly daily 5+ drinking, whereas Blacks had the lowest risk at all levels of 5+ drinking. CONCLUSIONS A disparity in alcohol-related injury was found for Hispanics compared with Whites at the same average monthly volume of consumption at lower and higher volume levels, but not at the same number of 5+ drinking days, and a lower risk of alcohol-related injury was found for Blacks for both consumption measures when demographic and socioeconomic status characteristics were taken into account. Although exposure to hazards other than alcohol, which could account for some of the racial/ethnic disparity observed, was not taken into account, these mixed findings suggest this is an important area deserving future research attention.
Correlation between blood and lymphatic vessel density and results of contrast-enhanced spectral mammography.

UNLABELLED Contrast-enhanced spectral mammography (CESM) is a novel technique used for detection of tumour vascularity by imaging the moment in which contrast, delivered to the lesion by blood vessels, leaks out of them, and flows out through lymphatic vessels. In our study, we included 174 women for whom spectral mammography was performed for diagnostic purposes. The relationship between enhancement in CESM and blood vessel density (BVD), lymphatic vessel density (LVD) or the percentage of fields with at least one lymphatic vessel (distribution of podoplanin-positive vessels - DPV) and other related parameters was assessed in 55 cases. BVD, LVD and DPV were assessed immunohistochemically, applying podoplanin and CD31/CD34 as markers of lymphatic and blood vessels, respectively. The sensitivity (in detection of malignant lesions) of CESM was 100%, while its specificity - 39%. We found a significant positive correlation between the intensity of enhancement in CESM and BVD (p = 0.007, r = 0.357) and a negative correlation between the intensity of enhancement in CESM and DPV (p = 0.003, r = -0.390). Lesions with the highest enhancement in CESM showed a high number of blood vessels and a low number of lymphatics. CONCLUSIONS 1) CESM is a method characterized by high sensitivity and acceptable specificity; 2) the correlation between CESM results and blood/lymphatic vessel density confirms its utility in detection of tissue angiogenesis and/or lymphangiogenesis.
Innovation and performance: A collection of microdata studies

There are still many puzzles to be solved concerning the relation between innovation and firm performance, in particular concerning the distinct roles of information and communication technology (ICT) and Research and Development (R&D) in creating new or improved products or production processes. This thesis provides evidence that both instances of innovation are important drivers of productivity and, thus, economic growth. The thesis consolidates the results of empirical work covering about 10 years of research on firm-level data that was aimed at understanding the importance for firm performance of innovation in a broad sense. Using econometric methods and recently developed innovation models, the several chapters investigate the distinct contributions to Total Factor Productivity (growth) of R&D and after controlling for the contributions of other inputs. In addition, special attention is given to role of ICT in enhancing the cumulativeness of innovation processes. This is achieved by analysing the interaction between technological and non-technological innovations and the role of ICT-related network externalities. It is shown that, especially in service production, ICT is an important driver of productivity (growth) and also an important enabler of other (non-technological) innovations. The cumulativeness of innovation is demonstrated by showing that firms that combine technological and non-technological innovations are among the most productive firms.
Electrostatic basis for the unidirectionality of the primary proton transfer in cytochrome c oxidase

Gaining detailed understanding of the energetics of the proton-pumping process in cytochrome c oxidase (CcO) is one of the challenges of modern biophysics. Despite promising mechanistic proposals, most works have not related the activation barriers of the different assumed steps to the protein structure, and there has not been a physically consistent model that reproduced the barriers needed to create a working pump. This work reevaluates the activation barriers for the primary proton transfer (PT) steps by calculations that reflect all relevant free energy contributions, including the electrostatic energies of the generated charges, the energies of water insertion, and large structural rearrangements of the donor and acceptor. The calculations have reproduced barriers that account for the directionality and sequence of events in the primary PT in CcO. It has also been found that the PT from Glu-286 (E) to the propionate of heme a3 (Prd) provides a gate for an initial back leakage from the high pH side of the membrane. Interestingly, the rotation of E that brings it closer to Prd appears to provide a way for blocking competing pathways in the primary PT. Our study elucidates and quantifies the nature of the control of the directionality in the primary PT in CcO and provides instructive insight into the role of the water molecules in biological PT, showing that “bridges” of several water molecules in hydrophobic regions present a problem (rather than a solution) that is minimized in the primary PT.
THE “AQUASCOPE” SIMPLIFIED MODEL FOR PREDICTING 89,90Sr, 131I, and 134,137Cs IN SURFACE WATERS AFTER A LARGE-SCALE RADIOACTIVE FALLOUT

Simplified dynamic models have been developed for predicting the concentrations of radiocesium, radiostrontium, and 131I in surface waters and freshwater fish following a large-scale radioactive fallout. The models are intended to give averaged estimates for radionuclides in water bodies and in fish for all times after a radioactive fallout event. The models are parameterized using empirical data collected for many lakes and rivers in Belarus, Russia, Ukraine, UK, Finland, Italy, The Netherlands, and Germany. These measurements span a long time period after fallout from atmospheric nuclear weapons testing and following the Chernobyl accident. The models thus developed were tested against independent measurements from the Kiev Reservoir and Chernobyl Cooling Pond (Ukraine) and the Sozh River (Belarus) after the Chernobyl accident, from Lake Uruskul (Russia), following the Kyshtym accident in 1957, and from Haweswater Reservoir (UK), following atmospheric nuclear weapons testing. The AQUASCOPE models (implemented in EXCEL spreadsheets) and model documentation are available free of charge from the corresponding author.
Coping with work-family conflicts in the global career context

In order to increase our understanding of the work-family conflicts experienced by global careerists and their families and the related coping strategies they adopt to address them, managers with long-term global careers were interviewed. The results indicate that the challenging nature of their jobs means global careerists face not only time-based and strain-based work-family conflicts but also mobility-based conflicts, a category added in order to fully capture the work-family conflicts faced. Managers were found mainly to use active problem-solving strategies alongside family-level coping strategies, though, in addition, emotional coping, avoidance, and reappraisal strategies were in evidence. ©2011 Wiley Periodicals, Inc.
Mechano-Physical Properties and Microstructure of Carbon Nanotube Reinforced Cement Paste after Thermal Load

The article presents the results obtained in the course of a study on the use of carbon nanotubes (CNTs) for the modification of a cement matrix. Carbon nanotubes were introduced into a cement paste in the form of an aqueous dispersion in the presence of a surfactant (SDS—sodium dodecyl sulfate), which was sonicated. The selected physical and mechanical parameters were examined, and the correlations between these parameters were determined. An analysis of the local microstructure of the modified cement pastes has been carried out using scanning electron microscope (SEM) and X-ray microanalysis (EDS). In addition, the effect of carbon nanotubes on the change in characteristics of the cementitious material exposed to the sudden, short-term thermal load, was determined. The obtained material was characterized by a much lower density than a traditional cement matrix because the phenomenon of foaming occurred. The material was also characterized by reduced durability, higher shrinkage, and higher resistance to the effect of elevated temperature. Further research on the carbon nanotube reinforced cement paste, with SDS, may contribute to the development of a modified cement binder for the production of a lightweight or an aerated concrete.
Explaining Diversity: Symmetry-Breaking in Complementarity Games

Strategic complementarity games have found applications in many fields, including macroeconomics, development, and labor economics. ' They provide a useful framework within which to address questions like: "What generates the disparity across regions and countries? " "Why are there booms and recessions? " and "What causes gender and race discrimination in the labor market? " In short, they help us think about the diversity and variations across space, time, and groups. The literature on complementarity games has emphasized coordination failures as the key notion to understand these questions. This paper argues that such emphasis is misplaced; the key to understand the diversity is symmetrybreaking. The notion of coordination failures is not only irrelevant, but also misleading when thinking about the diversity.
Women labour supply and country specific institutions

In this thesis, I study the influence of country-specific institutions on the labour supply decision of prime-aged women. In chapter 1, I use reduced-form methods, to evaluate the impact of wide changes to the benefit system and childcare subsidies targeted at households with pre-school age children in France. I estimate strong responses to maternity leave type benefits, and a positive impact of childcare subsidies on mothers employment rates in the long-run. In chapter 2, I develop and estimate a static labour supply model with part-time wage equations as well as demand-side constraints. I can compare the elasticities estimates and predictions from tax reform simulations to those of models assuming a unique hourly productivity and the absence of any employment constraint. The structural model also enables me to clearly simulate the impact of each component of the wide policy reform studied in the first chapter. In chapter 3, I try to understand why the number of hours worked by British married women is lower than that of French married women. I find that in the presence of children, British mothers are far more responsive to financial incentives. Husbands’ earnings and their interaction with childcare prices seem to play an important role. Nevertheless, the fall in hours worked in the British households with children, despite facing lower taxes than in France, remains somewhat puzzling. It could be mainly attributed (in the framework used) to different preferences. In the final chapter, I study the impact of joint-taxation on the labour supply choices of married women with working husbands in France. I simulate a revenue-neutral reform that would cancel the tax penalty or gain associated with being married. I find that the overall labour supply of these women would increase by 1.2%.
Coronary heart disease risk factors in men and women aged 60 years and older: findings from the Systolic Hypertension in the Elderly Program.

BACKGROUND Coronary heart disease (CHD) is the most common cause of death in men and women aged 60 years and older. Although a number of studies support the concept that CHD risk factors that have been defined in younger adults are significantly associated with CHD events in older adults, others do not support this thesis, and further definition of the risk-factor concept in older adults is required. METHODS AND RESULTS The Systolic Hypertension in the Elderly Program recruited 4736 persons (mean age, 72 years); 14% were black, and 43% were men. Mean systolic and diastolic blood pressures were 170 and 77 mm Hg, respectively. About 13% of participants were current smokers; 10% had a history of diabetes; 5%, a prior myocardial infarction; 5% angina pectoris; 2.3%, intermittent claudication; and 7%, a carotid bruit. Mean total cholesterol value was 6.11 mmol/L. Mean follow-up was 4.5 years. In multivariate Cox regression analyses for CHD, variables that were significant were baseline total cholesterol value, smoking, history of diabetes, presence of carotid bruit, and treatment group in the trial. Active treatment yielded a 27% reduction in CHD risk. For each 1.03 mmol/L increase in total cholesterol value, there was an increase in risk of about 20%. Current smokers had a 73% increase, diabetics a 121% increase, and those with carotid bruit a 113% increase in CHD risk. CONCLUSIONS The results of this study support the concept that CHD risk factors are important in older men and women with isolated systolic hypertension.
Factors that Determines the Success of Corporate Sustainability Management

The practice of Corporate Sustainability Management (CSM) is to believed strongly associated with management attitudes about the relationship of corporate sustainability management and corporate social responsibility. This literature review provides comprehensive indications that the CSM is an important management issue, complex and global nature. It is not apart from the company's position as a business institution that is able to influence and influenced by social conditions and environmental and position of management dilemma in meeting its profit and social responsibilities. CSM states that to survive in the long term, the management should have a balance between financial, social and environmental performance. The paradox attitude indicates economic interests are still the main reference in determining attitudes and policies of CSM. This article explores factors that determines the success of CSR program, which is corporate sustainability management. Using literature reviews, this article presents that at least there are five factors that should be met as a successful condition for the practice of CSM, namely: (1) the amount of commitments of shareholder to encourage the management engaged in solving social and environment issues, (2) the strength of humanist paradigm adopted by the management, (3) the ability of management achieves higher level sustainability performance, (4) the ability of management builds and run a strong sustainability culture that reflects the principles of sustainability properly and (5) the ability of management builds mutually beneficial collaboration with the economic stakeholders.
Street trade, neoliberalisation and the control of space: Nairobi's Central Business District in the era of entrepreneurial urbanism

Studies focusing on street trade in sub-Saharan Africa place great importance on the continuity with the colonial period and on the neocolonial characteristics of public action. This frame of reference, however pertinent it might be, does not account for all of the dynamics at work. I argue that it can benefit from an additional reading of what I characterise as the neoliberal dynamics also at work in these processes, drawing from governmentality studies and from the theories of ‘the urbanisation of neoliberalism’. The article discusses this hypothesis by examining the evolution of spatial politics on the streets of Nairobi's Central Business District (CBD) in the 2000s, focusing on a specific episode: the displacement of the street traders to an enclosed market located on the outskirts of the CBD. The first section considers the policies of street trade in Nairobi since the colonial period and the changes in their meaning under entrepreneurial rule, questioning the hypothesis of the colonial continuity. I then turn to an analysis of the neoliberal features of current street trade policies. I detail the emergence of the private sector as a major actor in the governance of street trade and its instrumental role in the crafting of a consultative procedure that has helped to reframe the traders' relationship to the state around the ideal of the responsible entrepreneurial citizen and contributed to enrolment as active participants in their own relocation.