Miracle-dz/UniFAR-FTUs huggingface dataset:
The rs2910164:G>C SNP in the MIR146A gene is not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

The rs2910164:G>C SNP is located in the gene for miR‐146a, a microRNA that binds the 3′ UTR of the BRCA1 transcript. Preliminary data based on the analysis of a small number of cases suggested that this single nucleotide polymorphism (SNP) might be associated with the age of onset of familial breast and ovarian cancer. This effect was not confirmed on a large series of familial breast cancer cases negative for a BRCA1 or BRCA2 mutation. We show here a lack of association of the rs2910164:G>C SNP with breast cancer risk in a series of 1,166 BRCA1 and 560 BRCA2 mutation carriers. In conclusion, the polymorphism in the miR‐146a gene is unlikely to be of substantial significance regarding breast cancer risk. Hum Mutat 32:1–4, 2011. © 2011 Wiley‐Liss, Inc.
An Abundance of Selves: Young Adults’ Narrative Identities While Living With Cancer

Background: Identity negotiations of people living with cancer have been shown to be significant psychosocial challenges throughout cancer trajectories but have not been adequately explored among young adults with cancer. Narrative approaches might help to reveal moments of (dis)empowerment that affect their identity negotiations. Objective: The aim of this study is to explore how young adults speak to their identities in relation to their narratives of having cancer and receiving care. Methods: A total of 21 young adults (18–45 years old) provided cancer narratives through semistructured life history interviews. Thematic narrative analysis was used to determine how participants represented themselves in their stories. Results: Participants used a wide diversity of identities well beyond those most familiar in dominant discourses (eg, patients, survivors, and fighters), and their identities frequently changed at significant “turning points” in their narratives, especially in relation to good and bad experiences of care. Conclusions: Cancer-related identities often undergo personal and social negotiation over time, and not just among young adults still feeling the effects of treatment. Psychosocial oncology could take further steps toward incorporating this fluidity and multiplicity within the discipline’s discourses of identity. Implications for Practice: The identities gathered here may contribute to a more comprehensive toolkit of narrative resources for empowering young adults (and others) with cancer, serving as a starting point for negotiating identities with their care providers. Our findings raise questions about which identities should be fostered and how healthcare professionals might be (unknowingly) involved in patients’ identity negotiations.
Sexual Behavior in Parked Cars Reported by Midwestern College Men and Women

In an anonymous survey of 195 men and 511 women (Mage = 19.8) at a small Midwestern university, 119 men (61%) and 303 women (59.5%) reported that they had engaged in sex while parked. Of these 422, 14% lost their virginity in a parked car. Having sex in parked cars was more likely to involve relational dating partners than hookups. In most recent incidents, the majority of respondents were with a serious but noncohabiting romantic partner (56.9%) in the back seat (63.4%) of a standard car (56.4%) parked out in the country (56.0%). The most common sexual acts were penile-vaginal sex and genital touching, reported by 84.6% and 57.5% of respondents, respectively. Condoms were used by 58.2% of respondents. Less than 1% of respondents reported sexually transmitted infections (STIs) or pregnancy outcomes. These data, including personal stories of memorable incidents, revealed that despite discomfort, body bumps, and risk of being caught, sex while parked was primarily a positive sexual and romantic experience for both men and women. A dark side of parked-car sex existed in that 2.5% of men and 4.3% of women reported being sexually coerced. The future study of sex in parked cars in urban environments is recommended.
Prediction of hand strength by hand injury severity scoring system in hand injured patients

Purpose: Hand strength is a key component in human hand function, especially to those with strength-required jobs. To evaluate post-injury hand strength, this study was conducted to assess the predictability of hand injury severity scoring (HISS) system to hand strength after a period of recovery. Methods: In this retrospective study, 80 traumatic hand-injured subjects were recruited. Hand strength tests measured by dynamometers were performed by subjects in ways of palmar pinch, lateral pinch and cylindrical grip. The logistic regression models were used to evaluate the risk of poor hand strength among the severities represented by HISS scores. Results: A positive correlation exists between the differences of the strength of two hands, and the severity shown by HISS system in the poorer half of subjects. The risk to be in poorer half of palmar pinch subtest is significant in moderate subgroup of HISS severity. The risk to be in poorer half of cylindrical grip subtest is significant in major subgroup of HISS severity. The risk to be in poorer half of palmar pinch and cylindrical grip subtests is significant in skeletal component of HISS system. Conclusions: HISS is a descriptive severity scoring system to hand injury and also a useful instrument to predict functional outcome. This study revealed the HISS system may predict post-injury hand strength after recovery. Implications for Rehabilitation: Hand injury Traumatic hand injury results in considerable loss of personal productivity and increased social burden. Hand injury severity scoring (HISS) system could be an adequate predictor to post-injury hand strength. Early rehabilitation intervention is mandatory to those with anticipatory poor hand strength to improve outcomes. Full motor recovery of hand injury may take years to complete. Further training is warranted to those with severe hand injury.
Laparoscopic adrenalectomy for potentially malignant adrenal tumors greater than 5 centimeters.

PURPOSE Laparoscopic adrenalectomy (LA) is controversial for large, potentially malignant tumors. We report a series of LA or hand-assisted LA for large (>5 cm) adrenal tumors. PATIENTS AND METHODS Among 210 LAs performed in 6 yr, 39 patients had potentially malignant tumors greater than 5 cm in diameter. Their perioperative and follow-up data were retrospectively analyzed. RESULTS All 39 patients had successful LAs without perioperative mortality, conversion to open surgery, or capsular disruption during dissection. The mean tumor size was 6.2 cm (range, 5-12 cm), operative time 207 min (115-315 min), and blood loss 75 ml (minimal-1400 ml). Complications included one intraoperative diaphragmatic perforation, three mild wound infections, and one pneumonia. Preoperatively there were 27 nonfunctioning tumors, seven pheochromocytomas, three cortisol-secreting tumors, and two virilizing tumors. Final pathology revealed eight malignant (four adrenocortical carcinomas and four metastatic carcinomas) and 31 benign tumors (14 cortical adenomas, eight pheochromocytomas, six myelolipomas, and three ganglioneuromas). Median follow-up was 39 months. Four patients (two adrenocortical carcinomas, one metastatic hepatoma, and one lymphoma) died 24, 10, 9, and 3 months after surgery, respectively. A hand-assisted device was used in 10 patients. Only the tumor size was larger and length of postoperative hospital stay longer for those in the hand-assisted group. CONCLUSIONS LA is a reasonable option for selected large adrenal tumors when complete resection is technically feasible and there is no evidence of local invasion. Hand-assisted LA is a good alternative to open conversion if a difficult dissection is encountered intraoperatively.
Uterine expression of sodium/potassium/calcium exchanger 3 and its regulation by sex‐steroid hormones during the estrous cycle of rats

Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. NCKX3 (gene SLC24A3), a potassium‐dependent sodium‐/calcium exchanger, plays a critical role in the transport of one intracellular calcium and potassium ion across the cell membrane in exchange for four extracellular sodium ions. NCKX3 transcripts are most abundant in the brain and smooth muscle, but many other tissues, in particular, the uterus, aorta and intestine, also express this gene at lower levels. However, the expression and physiological roles of NCKX3 in the uterus of rats during the estrous cycle are unknown. Thus, we examined the uterine expression of NCKX3 mRNA and protein at different stages of the estrous cycle in mature and immature female rats in the absence or presence of the sex‐steroid hormones estrogen (E2) and progesterone (P4). During the estrous cycle, uterine expression of NCKX3 mRNA and protein was enhanced up to 4.0‐ and 2.5‐fold, respectively, at proestrus compared to during estrus and diestrus. To examine the effect of sex steroids on NCKX3 regulation in the uterus, immature female rats were treated with E2 (40 µg/kg body weight; BW), P4 (4 mg/kg BW), or E2 plus P4 for 3 days. The expression of NCKX3 mRNA and protein was induced by E2, whereas P4 antagonized E2‐induced NCKX3 expression. Subsequent immunohistochemical analysis revealed that uterine NCKX3 protein was abundantly localized in the cytoplasm of luminal and glandular epithelial cells throughout the estrous cycle. Taken together, these results indicate that uterine NCKX3 is abundantly expressed in the uterus and that its expression is regulated by the steroid hormones, E2 and P4. These findings suggest that NCKX3 may be involved in reproductive function during the estrous cycle in female rats. Mol. Reprod. Dev. 77:971–977, 2010. © 2010 Wiley‐Liss, Inc.
Vascular endothelial growth factor in pleural effusions and correlation with radiologic and biochemical parameters

Introduction: Pleural effusion is a common clinical problem with management difficulties. The aim of this study is to evaluate vascular endothelial growth factor (VEGF) in differential diagnosis of pleural effusions and the presence of correlation between radiological features and biochemical properties. Materials and Methods: The study included patients with pleural effusion. VEGF levels in the pleural fluid were measured by enzyme-linked immunosorbent assay. Results: A total of 97 patients who had exudative pleural effusion related to lung cancer (n = 17), nonpulmonary malignancies (n = 25), mesothelioma (n = 9), pneumonia (n = 14), tuberculosis (n = 8), miscellaneous causes (n = 6), and transudative effusion (n = 18) were included. Pleural VEGF levels were higher in exudative effusions with respect to transudative effusions (P < 0.001) and in effusions related to malignancies versus benign causes (P < 0.001). Pleural VEGF was inversely correlated with pleural fluid glucose and pH levels and had positive correlation with lactate dehydrogenase, protein levels (P < 0.001), hematocrit, and eosinophil values in the pleura (P < 0.05). Pleural VEGF levels were also higher in patients with massive effusions and pleural thickening (both P < 0.001). Conclusions: The overlap of pleural VEGF levels between the groups may limit the value of VEGF in discriminating between malignant versus benign and exudative versus transudative effusions; however, it may be a useful adjunct to various methods. The VEGF levels in pleural fluid seem to be related to the degree of inflammation and pleural invasion.
Submicroscopic and multiple plasmodium falciparum infections in pregnant Sudanese women

Background: Control of malaria during pregnancy remains a major public health challenge in developing countries. Microscopic parasite detection represents a pivotal step in malaria control, while modern molecular techniques are deemed to improve detection rates markedly. Aims: This study aimed to investigate the frequency of submicroscopic and multiple Plasmodium falciparum (P. falciparum) infections during pregnancy, using the P. falciparum merozoite surface protein1 (MSP-1) gene as a polymorphic marker. Materials and Methods: The study was a cross-sectional, analytical study that was conducted at Omdurman Maternity Hospital, Sudan, between July 2003 and December 2004. Following informed consent, 836 pregnant women between the ages of 16-47 years with different gestational ages were enrolled in the study. Thin and thick blood films were stained with Giemsa and examined by experienced microscopists. Parasite DNA was extracted using Chelex method. Nested polymerase chain reaction (PCR) assays specific for P. falciparum were carried out to detect infections below the threshold of microscopy and to genotype different strains in the samples using merozoite surface protein-1. Results: More than a quarter of the study participants (219/836; 26.2%) were smear-positive for malaria infection. The results of the PCR-based assays showed that 41.8 % (257/617) of the smear-negative women were PCR positive and therefore had submicroscopic infections. The mean number of genetically different P. falciparum parasites detected was 2.7 (range 1–9). The multiplicity of infection identified by at least two alleles of MSP-1 was significantly higher among paucigravidae (45.6%) compared to multigravidae (28.9%), with mean number of alleles of 2.4 and 1.9, respectively (p=0.009). This likely indicates the gradual acquisition of immunity. Conclusion: Conventional microscopy underestimates the actual extent of malaria infections during pregnancy in endemic regions. Multiplicity of infection may be an important factor in the gradual acquisition of strain-specific immunity.
Proximity changes to what and for whom? Investigating sustainable accessibility change in the Gothenburg city region 1990–2014

ABSTRACT This paper operationalizes the concept of sustainable accessibility by emphasizing the environmental and social dimensions of sustainability from a spatial perspective. In doing so, we develop a heuristic model that focuses on the crucial dimensions of who gets access to what by using sustainable means of movement. We apply our conceptual approach in an examination of trends in sustainable accessibility for different social groups living in Gothenburg, Sweden between 1990 and 2014. On the basis of welfare-related and time-geographical considerations, we investigate accessibility by proximity for low- and high-income earners, people with small children, and elderly people. We investigate to what extent proximity to fundamental facilities increases or decreases over time, indicating changing conditions for sustainability. The results show that opportunities for living a local life and achieving accessibility via proximity differ socially. Low-income earners and the elderly generally live closer to the facilities important for daily life than do high-income earners and parents of young children. We also show that the opportunities for various social groups to obtain access by proximity change over time. For example, we observe a trend in which over time older people face reduced opportunities to reach daily facilities in their local neighborhoods.
Radio‐active Iodine Uptake in Vitiligo

Vitiligo and thyroid disease are commonly associated disorders. Twenty‐two clinically euthyroid vitiligo patients were studied for functional assessment of thyroid by radioactive iodine uptake assay. Half of them showed abnormal uptake values at 24 hours. Of these patients, 90% had lower values indicating a tendency towards developing hypothyroid state. Subclinical thyroid dysfunction in vitiligo appears to be an adaptive change.
Comparison of Modeling Grassland Degradation with and without Considering Localized Spatial Associations in Vegetation Changing Patterns

Grassland ecosystems worldwide are confronted with degradation. It is of great importance to understand long-term trajectory patterns of grassland vegetation by advanced analytical models. This study proposes a new approach called a binary logistic regression model with neighborhood interactions, or BLR-NIs, which is based on binary logistic regression (BLR), but fully considers the spatio-temporally localized spatial associations or characterization of neighborhood interactions (NIs) in the patterns of grassland vegetation. The BLR-NIs model was applied to a modeled vegetation degradation of grasslands in the Xilin river basin, Inner Mongolia, China. Residual trend analysis on the normalized difference vegetation index (RESTREND-NDVI), which excluded the climatic impact on vegetation dynamics, was adopted as a preprocessing step to derive three human-induced trajectory patterns (vegetation degradation, vegetation recovery, and no significant change in vegetation) during two consecutive periods, T1 (2000–2008) and T2 (2007–2015). Human activities, including livestock grazing intensity and transportation accessibility measured by road network density, were included as explanatory variables for vegetation degradation, which was defined for locations if vegetation recovery or no significant change in vegetation in T1 and vegetation degradation in T2 were observed. Our work compared the results of BLR-NIs and the traditional BLR model that did not consider NIs. The study showed that: (1) both grazing intensity and road density had a positive correlation to vegetation degradation based on the traditional BLR model; (2) only road density was found to positively correlate to vegetation degradation by the BLR-NIs model; NIs appeared to be critical factors to predict vegetation degradation; and (3) including NIs in the BLR model improved the model performance substantially. The study provided evidence for the importance of including localized spatial associations between the trajectory patterns for mapping vegetation degradation, which has practical implications for designing management policies to counterpart grassland degradation in arid and semi-arid areas.
Role of Nitric Oxide, Cyclic Nucleotides, and the Activation of ATP-Sensitive K+ Channels in the Contribution of Adenosine to Hypoxia-Induced Pial Artery Dilation

Previously, it had been observed that nitric oxide (NO) contributes to hypoxia-induced pial artery dilation in the newborn pig. Additionally, it was also noted that activation of ATP-sensitive K+ channels (KATP) contribute to cGMP-mediated as well as to hypoxia-induced pial dilation. Although somewhat controversial, adenosine is also thought to contribute to hypoxic cerebrovasodilation. The present study was designed to investigate the role of NO, cyclic nucleotides, and activation of KATP channels in the elicitation of adenosine's vascular response and relate these mechanisms to the contribution of adenosine to hypoxia-induced pial artery dilation. The closed cranial window technique was used to measure pial diameter in newborn pigs. Hypoxia-induced artery dilation was attenuated during moderate (PaO2 ≈ 35 mm Hg) and severe hypoxia (PaO2 ≈ 25 mm Hg) by the adenosine receptor antagonist 8-phenyltheophylline (8-PT) (10–5 M) (26 ± 2 vs. 19 ± 2 and 34 ± 2 vs. 22 ± 2% for moderate and severe hypoxia in the absence vs. presence of 8-PT, respectively). This concentration of 8-PT blocked pial dilation in response to adenosine (8 ± 2, 16 ± 2, and 23 ± 2 vs. 2 ± 2, 4 ± 2, and 6 ± 2% for 10–8, 10–6, and 10–4 M adenosine before and after 8-PT, respectively). Similar data were also obtained using adenosine deaminase as a probe for the role of adenosine in hypoxic pial dilation. Adenosine-induced dilation was associated with increased CSF cGMP concentration (390 ± 11 and 811 ± 119 fmol/ml for control and 10–4 M adenosine, respectively). The NO synthase inhibitor, L-NNA, and the cGMP antagonist, Rp 8-bromo cGMPs, blunted adenosine-induced pial dilation (8 ± 1, 14 ± 1, and 20 ± 3 vs. 3 ± 1, 5 ± 1, and 8 ± 3% for 10–8, 10–6, and 10–4 M adenosine before and after L-NNA, respectively). Adenosine dilation was also blunted by glibenclamide, a KATP antagonist (9 ± 2, 14 ± 3, 21 ± 4 vs. 4 ± 1, 8 ± 2, and 11 ± 2% for 10–8, 10–6, and 10–4 M adenosine before and after glibenclamide, respectively). Finally, it was also observed that adenosine-induced dilation was associated with increased CSF cAMP concentration and the cAMP antagonist, Rp 8-bromo cAMPs, blunted adenosine pial dilation. These data show that adenosine contributes to hypoxic pial dilation. These data also show that NO, cGMP, cAMP, and activation of KATP channels all contribute to adenosine induced pial dilation. Finally, these data suggest that adenosine contributes to hypoxia-induced pial artery dilation via cAMP and activation of KATP channels by NO and cGMP.
Real exchange rate misalignment and macroeconomic implications: recent evidence from Ghana

We evaluate the degree of real exchange rate (REER) misalignment and its macroeconomic implications for the Ghanaian economy using quarterly data (2000Q1-2015Q3). Our results uncovered a clear misalignment of the actual REER from its equilibrium level throughout the sample period, although the REER was close to its equilibrium level at the end of 2012. The study also revealed a weak positive undervaluation-economic growth nexus for Ghana. Overvaluation was observed to exert disinflationary pressures, while undervaluation tends to increase inflationary pressures in Ghana. The study thus suggests that the use of REER undervaluation as a deliberate industrial policy instrument for sustained economic growth may be counterproductive in the context of Ghana, as such policy may potentially undermine price stability objective of the central bank. Keywords : Equilibrium Exchange Rate; Misalignment;Ghana.
The Populist Challenge to Liberal Democracy

Abstract:Across the West, economic dislocation and demographic change have triggered a demand for strong leaders. This surge of populism is more than an emotional backlash; it encourages a political structure that threatens liberal democracy. While populism accepts principles of popular sovereignty and majoritarianism, it is skeptical about constitutionalism and liberal protections for individuals. Moreover, populists’ definition of “the people” as homogeneous cannot serve as the basis for a modern democracy, which stands or falls with the protection of pluralism. Although this resurgent tribalism may draw strength from the incompleteness of life in liberal society, the liberal-democratic system uniquely harbors the power of self-correction, the essential basis for needed reforms.
[Influenza vaccination coverage rate in children with underlying chronic disorders in 7 French pediatric wards].

UNLABELLED In France, annual influenza vaccination is recommended and free of charge for children with chronic disease (chronic lung, heart or kidney disease, diabetes, haemoglobinopathy, immune deficiency). The national goal is to reach 75% influenza vaccination coverage by 2008, but data on coverage in high risk children are limited. OBJECTIVES To estimate the influenza vaccination coverage in children with an underlying chronic health condition in the Paris region, during in- or out-patient visit at hospital. METHODS A multicentre cross-sectional descriptive study was carried out over 2 months before the 2004-2005 flu vaccination campaign in 7 French paediatric hospitals (Paris region). Inclusion criteria for this survey were: children aged 6 months to 18 years, with an underlying chronic disease requiring annual influenza vaccination, with a vaccination card available, so as to check their vaccination status. Reasons for non vaccination were recorded. RESULTS Data from 239 children were analysed. 56% of patients were males (mean age: 8.1 years). Two patients had 2 separate underlying chronic disorders; 69% had a haemoglobinopathy, 16.3% had a chronic respiratory disease, and 7.5% had diabetes. The influenza vaccination rate for 2003-2004 was 43.7% (haemoglobinopathy: 55.5%; chronic respiratory diseases: 12.8%). This rate increased from 20.4% to 43.7% between 1999 and 2003. Less than 16% of parents remembered having received a voucher for free vaccination from the National Health Insurance Agency. CONCLUSION Efforts are still needed to achieve the 2008 objectives of 75% coverage.