Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonbinding site-directed mutants of transferrin binding protein B enhances 1 their immunogenicity and protective capabilities 2 3 Short Title : Improved immunogenicity of mutant TbpB 4 5

33 Host adapted Gram-negative bacterial pathogens from the Pasteurellaceae, Neisseriaceae 34 and Moraxellaceae families normally reside in the upper respiratory or genitourinary 35 tracts of their hosts and rely on utilizing iron from host transferrin (Tf) for growth and 36 survival. The surface receptor proteins that mediate this critical iron acquisition pathway 37 have been proposed as ideal vaccine targets due to the critical role that they play in 38 survival and disease pathogenesis in vivo. In particular, the surface lipoprotein 39 component of the receptor, Tf binding protein B (TbpB), had received considerable 40 attention as a potential antigen for vaccines in humans and food production animals but 41 this has not translated into the series of successful vaccine products originally envisioned. 42 Preliminary immunization experiments suggesting that host Tf could interfere with 43 development of the immune response prompted us to directly address this question with 44 site-directed mutant proteins defective in binding Tf. Site-directed mutants with 45 dramatically reduced binding of porcine transferrin and nearly identical structure to the 46
Interactive comment on “A comparison of two chemistry and aerosol schemes on the regional scale and resulting impact on radiative properties and warm and cold aerosol-cloud interactions” by

The authors compared impacts of two different aerosol module, MADE with full gasphase chemistry and M7 with a constant-oxidant-field-based sulfur cycle, on aerosol burden, as well as aerosol-cloud interactions. They found that aqueous-phase sulfate production, the selection of aerosol species and modes and modal composition are more important than parametric choices for aerosol populations. Differences in cloud droplet and ice crystal number concentrations are buffered by cloud microphysics. This study could improve the understanding on implication of aerosol schemes in air quality and climate models. Before this manuscript can be considered for publication, I have a few comments that need to be addressed by the authors.
FC FC Squared Loss on image-level labels + + + + + 0 Segmenta ti on Goundtruth Global Image-level Context Image

In this work, we address the human parsing task with a novel Contextualized Convolutional Neural Network (Co-CNN) architecture, which well integrates the cross-layer context, global image-level context, semantic edge context, within-super-pixel context and cross-super-pixel neighborhood context into a unified network. Given an input human image, Co-CNN produces the pixel-wise categorization in an end-to-end way. First, the cross-layer context is captured by our basic local-to-global-to-local structure, which hierarchically combines the global semantic information and the local fine details across different convolutional layers. Second, the global image-level label prediction is used as an auxiliary objective in the intermediate layer of the Co-CNN, and its outputs are further used for guiding the feature learning in subsequent convolutional layers to leverage the global imagelevel context. Third, semantic edge context is further incorporated into Co-CNN, where the high-level semantic boundaries are leveraged to guide pixel-wise labeling. Finally, to further utilize the local super-pixel contexts, the within-super-pixel smoothing and cross-super-pixel neighbourhood voting are formulated as natural sub-components of the Co-CNN to achieve the local label consistency in both training and testing process. Comprehensive evaluations on two public datasets well demonstrate the significant superiority of our Co-CNN over other state-of-the-arts for human parsing. In particular, the F-1 score on the large dataset [1] reaches 81.72% by Co-CNN, significantly higher than 62.81% and 64.38% by the state-of-the-art algorithms, MCNN [2] and ATR [1], respectively. By utilizing our newly collected large dataset for training, our Co-CNN can achieve 85.36% in
After Ulcerative Colitis and Familial Adenomatous Polyposis Stages and Evaluation of Surgical Innovation : A Clinical Example of the Ileo Neorectal Anastomosis

Aim. So far, not many clinical examples that follow the IDEAL (Idea, Development, Evaluation, Assessment, and Longterm study) recommendations for evaluating and reporting surgical innovation and adoption are available. Methods. In this article, all IDEAL stages will be described for a recent surgical innovation, the ileo neorectal anastomosis (INRA), a procedure restoring intestinal continuity after colectomy. Results. INRA showed that the technique of small-bowel transposition with a vascular pedicle is feasible, with good long-term results. From the patient’s point of view, no distinct advantage for INRA was found, with morbidity and functional results being in range with the gold standard ileal pouch anal anastomosis. Conclusion. The adoption of the IDEAL recommendations—that is, by performing evidencebased surgical studies—will improve surgical science, with the consequence that progress in surgical care continues and interventions become safer and more efficient and allow a better quality of life in surgical patients.
The Leu 33 Pro polymorphism in the gene does not modify-associated breast or ovarian cancer risks : results from a multicenter study among 15 , 542 and mutation carriers

Integrins containing the b3 subunit are key players in tumor growth and metastasis. A functional Leu33Pro polymorphism (rs5918) in the b3 subunit of the integrin gene (ITGB3) has previously been suggested to act as a modifier of ovarian cancer risk in Polish BRCA1 mutation carriers. To investigate the association further, we genotyped 9,998 BRCA1 and 5,544 BRCA2 mutation carriers from 34 studies from the Consortium of Investigators of Modifiers of BRCA1/2 for the ITGB3 Leu33Pro polymorphism. Data were analysed within a Cox-proportional hazards framework using a retrospective likelihood approach. There was marginal evidence that the ITGB3 polymorphism was associated with an increased risk of ovarian cancer for BRCA1 mutation carriers (per-allele Hazard Ratio (HR) 1.11, 95% CI 1.00–1.23, p-trend 0.05). However, when the original Polish study was excluded from the analysis, the polymorphism was no longer significantly associated with ovarian cancer risk (HR 1.07, 95% CI 0.96–1.19, p-trend 0.25). There was no evidence of an association with ovarian cancer risk for BRCA2 mutation carriers (HR 1.09, 95% CI 0.89–1.32). The polymorphism was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers. The ITGB3 Leu33Pro polymorphism does not modify breast or ovarian cancer risk in BRCA1 or BRCA2 mutation carriers.
Post Activation Potentiation in North American High School Football Players: 1638 Board #313 June 1 9

Post activation potentiation (PAP) is an acute enhancement of muscular power production resulting from a high intensity potentiating exercise. Practical applications of the PAP phenomena as a warmup strategy are the focus of ongoing research. This study compared the effects of a dynamic and a PAP warm up strategy on speed and horizontal plane muscular power output. High School male football players (n = 16) participated in a repeated measures cross over design study consisting of 3 testing days. Day 1: one repetition maximum (1-RM) back squats were established. Day 2: half of the participants completed a dynamic warmup consisting of dynamic movements (ex. high knees, butt kickers, frog jumps, cherry pickers, lateral slide, karaokes, back pedal) while the other half of the participants performed a PAP warmup consisting of back squats culminating in a set of 4 repetitions at 85% of 1-RM. Following the warmups (4-minutes), the participants performed 3 trials of a weighted sled push 91 kilograms (200 pounds) over a 9.1 meter (10 yards) linear path. Following the sled pushes, the participants then performed three trials of 18.2 meter (20 yards) sprints. Day 3: participants crossed over with respect to the warmup procedures and again performed the three sled push and sprint trials. Dependent t-tests were used to compare the sled push and sprint times between warm up conditions. Both the 18.2 meter sprint (P < 0.01) and the 91 kilogram sled push (P < 0.01) showed a significant improvement when PAP was utilized as a warmup, rather than the dynamic warmup. Within the parameters of the study, it is concluded that PAP as a warm up strategy enhances sprint ability and horizontal plane muscular power output.
Reciprocal phenotypic plasticity in a predator–prey system: inducible offences against inducible defences?

We describe one of the first examples of reciprocal phenotypic plasticity in a predator‐ prey system: the interaction between an inducible defence and an inducible offence. When confronted with the predatory ciliate Lembadion bullinum, the hypotrichous ciliate Euplotes octocarinatus develops protective lateral wings, which inhibit ingestion by the predator. We show that L. bullinum reacts to this inducible defence by expressing an inducible offence ‐ a plastic increase in cell size and gape size. This counteraction reduced the effect of the defence, but did not completely neutralize it. Therefore, the defence remained beneficial for E. octocarinatus. From L. bullinums point of view, the increase in feeding rate because of the offence was not larger than the increase in mean cell volume and apparently, did not increase the predator’s fitness. Therefore, the inducible offence of L. bullinum does not seem to be an effective counter-adaptation to the inducible defence of E. octocarinatus.
Community Birth Cohort in a Rural Egyptian with Enterotoxigenic Escherichia coli in a Diarrhea Burden Due to Natural Infection

Published Ahead of Print 14 May 2014. 10.1128/JCM.00215-14. 2014, 52(7):2595. DOI: J. Clin. Microbiol. P. J. Sebeny, J. D. Klena, S. Y. N. Young and R. W. Frenck Svennerholm, Sanders, M. S. Riddle, A. W. Armstrong, A. M. A. Mansour, H. I. Shaheen, M. Amine, K. Hassan, J. W. Community Birth Cohort in a Rural Egyptian with Enterotoxigenic Escherichia coli in a Diarrhea Burden Due to Natural Infection
Monocytes Helicobacter pylori with Human Dendritic Comparative Analysis of the Interaction of

Published Ahead of Print 21 May 2012. 2012, 80(8):2724. DOI: 10.1128/IAI.00381-12. Infect. Immun. Thomas F. Meyer, Toni Aebischer and Ralf Ignatius Pang, Elena Belogolova, Yuri Churin, Thomas Schneider, Viveros, Jana Hagen, Macarena Beigier-Bompadre, Ervinna Michael Fehlings, Lea Drobbe, Verena Moos, Pablo Renner Cells, Macrophages, and Monocytes Helicobacter pylori with Human Dendritic Comparative Analysis of the Interaction of
1 Material and Methods 1 . 1 A brief introduction to Variational Bayes ( VB ) Variational

Detection-nondetection data are often used to investigate species range dynamics using Bayesian occupancy models which rely on the use of Markov chain Monte Carlo (MCMC) methods to sample from the posterior distribution of the parameters of the model. In this article we develop two Variational Bayes (VB) approximations to the posterior distribution of the parameters of a single-season site occupancy model which uses logistic link functions to model the probability of species occurrence at sites and of species detection probabilities. This task is accomplished through the development of iterative algorithms that do not use MCMCmethods. Simulations and small practical examples demonstrate the effectiveness of the proposed technique. We specifically show that (under certain circumstances) the variational distributions can provide accurate approximations to the true posterior distributions of the parameters of the model when the number of visits per site (K) are as low as three and that the accuracy of the approximations improves as K increases. We also show that the methodology can be used to obtain the posterior distribution of the predictive distribution of the proportion of sites occupied (PAO).
Climatic Factors Affecting the Growth of Larix cajanderi in the Kamchatka Peninsula, Russia

Abstract Tree-ring width chronology of larch (Larix cajanderi) was developed in the lowland in the central part of the Kamchatka Peninsula in Russia, and climatic factors affecting the growth of larch were examined by using monthly temperature, precipitation and water deficit [(potential evapotranspiration) - (precipitation)]. Eighteen disks oflarch were examined, and a tree-ring index was developed by using five-year moving averages. Tree-ring indexes of sampled trees were positively correlated with each other, suggesting that many trees grew synchronously. A standardized tree-ring index (RI) was developed from A.D. 1840 to 1996 by averaging tree-ring indexes among sampled trees in each year. A correlation test revealed that RI was negatively correlated with precipitation in April in the current year. In addition, RI was positively correlated with precipitation and negatively with water deficit during the growing season (June-September) in the previous year. This was probably due to low precipitation in this region: mean precipitation during the growing season was only 171 mm, and water deficit was 183 mm. Therefore, drought stress during the growing season is an important factor affecting the growth of larch in the lowland of the central Kamchatka. Key words: Climatic factor; Kamchatka Peninsula; Larix cajanderi; Tree ring Introduction The regeneration of trees at the timberline or in boreal forests is supposed to be sensitive to climate change, and therefore, tree-ring information there is useful for re-constructing past climates. Many attempts have been conducted to reveal effects of climatic changes on tree growth and to re-construct past climate by analyzing tree rings (e.g., Sweda and Takeda 1993, Yasue et al. 1996, Gindl 1999). Several researchers reported that tree growth and recruitment rates increased in ameliorated years than the average in boreal forests or at the timberline (Kullman 1986; Steijlen and Zackrisson 1987; Hofgaard 1993; Kullman 1993; Taylor 1995; Camarero and Gutierrez 1999). Most of these studies have been conducted in the Scandinavia Peninsula, North America and the northwestern part of Russia. However, there have been few studies in the eastern part of Russia. Recently, tree-ring chronological studies have been started in the Kamchatka Peninsula in the Russian Far East. In the central part of the Kamchatka Peninsula, larch (Larix cajanderi Mayr.) is a long-lived species
Integrative Cancer Therapies

Pancreatic carcinoma remains one of the main causes for cancer-related death. Intratumoral application of anticancer agents is discussed as a promising method for solid tumors such as pancreatic cancer. Endoscopic ultrasound provides a good tool to examine and treat the pancreas. European mistletoe (Viscum album L) is a phytotherapeutic commonly used in integrative oncology in Central Europe. Its complementary use seeks to induce immunostimulation and antitumoral effects as well as alleviate chemotherapeutic side effects. Intratumoral mistletoe application has induced local tumor response in various cancer entities. This off-label use needs to be validated carefully in terms of safety and benefits. Here we report on 39 patients with advanced, inoperable pancreatic cancer, who received in total 223 intratumoral applications of mistletoe, endoscopic ultrasound guided or under transabdominal ultrasound control. No severe procedure-related events were reported. Adverse drug reactions were mainly increased body temperature or fever in 11% and 14% of the applications, respectively. Other adverse drug reactions, such as pain or nausea, occurred in less than 7% of the procedures. No severe adverse drug reaction was recorded. Patients received standard firstand second-line chemotherapy and underwent adequate palliative surgical interventions as well as additive subcutaneous and partly intravenous mistletoe application. A median survival of 11 months was observed for all patients, or 11.8 and 8.3 months for stages III and IV, respectively. Due to the multimodal therapeutic setting and the lack of a control group, the effect of intratumoral mistletoe administration alone remains unclear. This retrospective analysis suggests that intratumoral-applicated mistletoe might contribute to improve survival of patients with pancreatic cancer. In conclusion, the application is feasible and safe, and its efficacy should be evaluated in a randomized controlled trial.
Janet Study with Abnormal Smears : the Predictors 2 WomenCervical Intraepithelial Neoplasia in Comparison of Seven Tests for High-Grade

Published Ahead of Print 14 March 2012. 10.1128/JCM.00181-12. 2012, 50(6):1867. DOI: J. Clin. Microbiol. Lyons and Jack Cuzick Corrina Wright, Christine Bergeron, W. P Soutter, Deirdre Stuart Liddle, Martin Young, Mark Stoler, Julie McCarthy, Austin, Lesley Ashdown-Barr, Linda Ho, George Terry, Anne Szarewski, David Mesher, Louise Cadman, Janet Study with Abnormal Smears: the Predictors 2 Women Cervical Intraepithelial Neoplasia in Comparison of Seven Tests for High-Grade
The First Step of the Capital Flow from Institutions to Entrepreneurs: The Criteria for Sorting Venture Capital Funds

We contribute to the knowledge of the capital flow from institutional investors via venture capital (VC) funds as intermediaries to their final destination, entrepreneurial ventures. To this end, we conduct a worldâ€ wide survey among limited partners to determine the importance of several criteria when they select VC funds. We find the top criteria to be the expected deal flow and access to transactions, a VC fund's historic track record, his local market experience, the match of the experience of team members with the proposed investment strategy, the team's reputation, and the mechanisms proposed to align interest between the investors and the VC funds. A principal component analysis reveals three latent drivers in the selection process: â€˜Local Expertise and Incentive Structureâ€™, â€˜Investment Strategy and Expected Implementationâ€™, and â€˜Prestige/Standing vs. Costâ€™. It becomes evident that limited partners search for teams which are able to implement a certain strategy at a given cost. Thereby, they focus on an incentive structure that limits agency costs.
Diabetes Mellitus and its Control by Ocimum sanctum Extract in Mice Diabetic Model

Diabetes mellitus is a syndrome with disordered metabolism and inappropriate hyperglycemia due to either a deficiency of insulin secretion or to a combination of insulin resistance and inadequate insulin secretion to compensate. There are two classes of diabetes mellitus, Type1 and Type2. Type1 diabetes is due to pancreatic islet B cell destruction predominantly by an autoimmune process, and these patients are prune to ketoacidosis. Type2 diabetes is the more prevalent form and results from insulin resistance with a defect in compensatory insulin secretion.
Interactive comment on “ Regime dependence of Aerosol Effects on the Formation and Evolution of Pyro-convective clouds ”

Authors have addressed my comments adequately, except one errorneous reference. Wang et al., ACP, 2011 should be: Wang, Y. , Q. Wan, W. Meng, F. Liao, H. Tan, R. Zhang, Long-term impacts of aerosols on precipitation and lightning over the Pearl River Delta megacity area in China, Atmo. Chem. Phys., 11(23), 12421-12436, (2011) Response: Thanks for the correction. We have corrected this reference. Please see Line 356.
Jacques Corbeil , Assay Immunoassay and Cell Culture Cytotoxicity Diagnostic Tests Based on Enzyme Cycle Thresholds , and Results of Bacterial Load , Commercial Real-Time PCR Correlation between Clostridium difficile

Published Ahead of Print 21 August 2013. 10.1128/JCM.01444-13. 2013, 51(11):3624. DOI: J. Clin. Microbiol. Jean Longtin, Philippe Gervais and Yves Longtin Léa-Laurence Dionne, Frédéric Raymond, Jacques Corbeil, Assay Immunoassay and Cell Culture Cytotoxicity Diagnostic Tests Based on Enzyme Cycle Thresholds, and Results of Bacterial Load, Commercial Real-Time PCR Correlation between Clostridium difficile
Presenteeism of hotel employees: interaction effects of empowerment and hardiness

Purpose This study aims to investigate the two-way interaction effects of empowerment and hardiness on the presenteeism of hotel employees. Design/methodology/approach Data were collected from 358 hotel employees in Sabah, East Malaysia, via a questionnaire survey and analyzed using multiplicative regression analysis. Findings The results confirm the presence of a two-way interaction effect between empowerment and hardiness on the presenteeism of hotel employees at a significance level of 0.01. Further analysis indicates that the higher the level of hardiness, the greater is its negative effect on the relationship between empowerment and the presenteeism of hotel employees. Research limitations/implications The survey was cross-sectional and causal relationships among the variables cannot be inferred. The results were gathered from selected hotels and should not be generalized to all hotel employees in Sabah, East Malaysia. Practical implications The findings challenge the assumption of a positive association between empowerment and presenteeism and demonstrate that different levels of hardiness can influence this relationship. When empowering employees, management staff should also consider the provision of resilience-related training programs for less hardy employees. This would enable such employees to handle their presenteeism behavior arising from the increased level of empowerment. Originality/value This study provides the first empirical evidence of a two-way interaction effect of predictors on the presenteeism of hotel employees and could serve to influence mainstream journals in the presenteeism literature. Researchers could apply the analytical approach to examine future studies relating to higher-order effects of predictors on the presenteeism of hotel employees.
Agric . Econ . – Czech , 63 , 2017 ( 9 ) : 400 – 410

In the agricultural industry, many brokers exploit the benefi ts between farmers and customers and decrease the farmers’ income. As the technology has developed, the internet has become the best advertising medium for many industries. In light of this, this study based on the Google Earth has designed an on-line Agricultural Products Navigation System operated by mobile devices which can easily exclude brokers, and build the bridge between farmers and customers in order to increase the farmers income and customer benefi ts. Moreover, based on the IS success model of DeLone and McLean, by using the qualitative methodology, it is expected that this model will be able to provide system developers with the knowledge to improve the success of their systems.