Miracle-dz/UniFAR-FTUs huggingface dataset:
Dead time compensation method based on current ripple estimation

This paper discusses the voltage error caused by the dead time in voltage-source PWM converters. The theoretical analysis in this paper derives the nonlinear voltage error paying attention to the parasitic output capacitance in each switching device. The analytical result reveals that the turn-off current or the switching current ripple strongly affects the voltage error. In addition, it is clarified that the conventional compensation methods based on linear and three-level approximation are suitable under small and large current ripple conditions, respectively. A simple calculation method of current ripples in three-phase PWM converters are also developed to estimate the turn-off currents. A new compensation method based on the analysis is developed and compared with three different conventional methods in experiments using a 200-V, 5-kW three-phase grid-connection converter. The analysis-based method exhibits a good compensation performance having a lower current THD than the conventional methods in allover the operating range.
Chlamydia trachomatis infection, Fallopian tube damage and a mannose-binding lectin codon 54 gene polymorphism.

BACKGROUND Mannose-binding lectin (MBL), a component of the innate immune system, provides a first-line defense against invading microorganisms. Polymorphisms in the MBL gene have been associated with increased risk of infection. Chlamydia trachomatis genital tract infections are a major cause of Fallopian tube occlusion. Our objective was to test whether an MBL codon 54 polymorphism might contribute to development of C. trachomatis-associated tubal damage. METHODS In a case-control study, 97 women with occluded and 104 women with patent Fallopian tubes were tested for a history of chlamydial infection by serology and for their MBL codon 54 genotype by PCR and restriction fragment length polymorphism analysis. Clinical data were blinded to those performing all laboratory analyses. RESULTS Women with tubal occlusion who also had a positive chlamydial serology had the highest rate of variant MBL B allele carriage (P<0.001). Among women who were chlamydial antibody negative, allele B carriage was also more frequent in those with blocked, as opposed to patent, Fallopian tubes (P<0.01). CONCLUSIONS Wild-type allele A homozygosity is protective against, while carriage of the variant allele B is a risk factor for, Fallopian tube occlusion in women who are seropositive or seronegative for C. trachomatis.
Successful extracorporeal life support in a case of severe flecainide intoxication

ObjectiveTo show the effectiveness of emergency extracorporeal membrane oxygenation (ECMO) in treating severe, life-threatening flecainide intoxication. DesignCase report. SettingIntensive care unit in a quaternary care center. PatientA patient with electromechanical dissociation after severe flecainide acetate overdose. InterventionECMO. Case Report A 30-yr-old male with a history of depression presented after a severe flecainide overdose with plasma concentrations exceeding 20 times the upper boundary of the therapeutic range. At presentation, the patient was in refractory cardiocirculatory collapse and was successfully resuscitated with ECMO. Twenty-six hours later, extracorporeal support could be discontinued and the patient made a full recovery. ConclusionIn patients with severe but potentially reversible cardiac dysfunction attributable to flecainide intoxication, ECMO can maintain cardiac output and vital organ perfusion while allowing time for drug redistribution, metabolism, and clearance.
Does the Organization and Culture of the Largest Audit Firms Influence their Audit Quality and Efficiency

This study investigates the association between the largest audit firms’ internal organization and audit quality and efficiency. Using a unique dataset of firm-wide deficiencies in the quality control (QC) systems identified by the PCAOB during its inspections of audit firms, I find a negative association between firm-level QC deficiencies and audit quality. Furthermore, audits conducted by audit firms with more organization-level deficiencies are less efficient, as evidenced by more hours worked on the engagements, despite audit fees remaining unchanged. These results appear to be partly driven by deficiencies in the tone at the top (a proxy for culture) and the audit methodology. In contrast, audit firms with more deficiencies of a practical nature (audit performance issues) do not appear to spend enough effort on their audit, consistent with a “shirking” hypothesis. Overall, these results suggest that while both practical-level and organization-level deficiencies negatively influence audit quality, their root causes are different. In particular, audit firms may have the possibility to improve their profits once they remediate the organization-level deficiencies identified by the PCAOB.
PENGARUH GOOD CORPORATE GOVERNANCE DAN UKURAN PERUSAHAAN TERHADAP MANAJEMEN LABA (Studi Empiris pada Perusahaan LQ45 yang Terdaftar di Bursa Efek Indonesia Periode 2011 – 2014)

This study aims to look at the effect of Good Corporate Governance characteristics and the size of the company's to earnings management. This study population is LQ45 companies listed in Indonesia Stock Exchange 2011-2014 period. Based on the purposive sampling method, acquired 22 companies as samples in this study. Research data analysis techniques using Multiple Linear Regression Analysis with SPSS statistical program. The results of study carried out showed that the presence of independent board, institutional ownership, the size of the company's audit committee and significant effect on earnings management. While the managerial ownership no significant effect on earnings management. The coefficient of determination (R2) of 0.439, or 43.9%, meaning that earnings management is explained by the presence of independent board, institutional ownership, the audit committee and the size of the company amounted to 43.9%. While 56.1% is explained by other variables that are not included in this study. Keywords: Earnings management, good corporate governance and the Company Size
The immunological synapse: integrins take the stage

Summary: Adhesive interactions play important roles in coordinating T‐cell migration and activation, specifically in the formation of the immunological synapse (IS), a specialized cell‐cell junction. Recent demonstrations show several molecules implicated in T‐cell signaling, including Vav, ADAP, and Rap‐1, have major roles in integrin regulation and place adhesion molecules at center stage in addressing the question: what are the signals involved in the formation of the IS and full T‐cell activation? This review focuses on the role of integrins as an essential system for both physical adhesion and signaling in T‐cell activation. The role of integrins appears to be quite distinct from classical costimulation and has been largely overlooked due to the ubiquitous use of serum in lymphocyte functional assays. Each major signal transduction pathway has branches leading to the nucleus and others that feed back on cytoskeletal and membrane regulation at the IS.
Modelling radioimmunotherapy with anti-CD45 antibody to obtain a more favourable biodistribution

Summary Radioimmunotherapy (RIT) is a method to selectively deliver radiation to malignant haemato logical cells by addressing specific antigens. One approach to improve the bio-distribution is to administer a preload of unlabelled antibodies. The aim of this study was to develop a model, which describes distribution of labelled and unlabelled antibodies based on the tissue blood flow and the competing binding behaviour of the antibodies. Such a model can be used to improve biodistribution in the particular case of RIT using anti-CD45 antibodies. Methods: A compartmental model for the interconnected organs was developed. Reaction constants and organ specific flow, antigen concentrations and distribution volumes were taken from the literature. The organ residence times were calculated for different amounts of given labelled and unlabelled antibodies and the time delay between their administrations. Results: The model is capable to describe the preloading effect. The biodistribution of labelled or unlabelled antibodies depends essentially on the specific blood flow to the organ and its antigen expression. The dose ratio of bone marrow to liver is maximized by applying sufficient unlabelled monoclonal antibody (mAb) to saturate antibody binding in the competing organs and by applying the labelled mAb with a delay of more than one hour. Conclusions: The developed model qualitatively describes how a preload can considerably increase selectivity of RIT due to different blood flows and antigen distribution in relevant organs. In addition, simulations can identify the optimal delay between the application of labelled and unlabelled antibody. For future analyses, i.e., to fit patient data, degradation and excretion should be incorporated into the model.
An empirical analysis of the relationships between the interactive use of performance measurement systems and individual performance : the intervening roles of psychological empowerment, affective organisational commitment and creativity

There is considerable interest in the role of management control systems (MCS) in enhancing innovation and performance in organisations. An aspect of MCS that has attracted recent attention is the role of performance measurement systems (PMS) in organisational innovation. However, as yet, there has been little consideration given to identifying the nature of the relationship between PMS and creativity at an individual level. This study examines the effect of the interactive use of PMS on creativity and performance. Middle-level managers of large Australian manufacturing organisations were surveyed. The study identifies a key intervening variable, psychological empowerment, as being instrumental in the interactive use of PMS leading to the enhancement of creativity and performance in individuals. Psychological empowerment was also found to mediate the associations between the interactive use of PMS, creativity and performance.
The Interplay of Strategic Management and Information Technology

The authors trace historical developments in the fields of information technology (IT) and strategic management. IT’s evolution from the mainframe era to the Internet era has been accompanied by a shift in the strategic emphasis of IT. In the early days, IT’s contribution to the organization was largely information provision, monitoring and control. Current research at the intersection of IT and strategic management increasingly highlights the impact of IT in terms of informing strategic decisions and enabling information flow vis-àvis all manner of organizational processes. We believe these fields are ripe for research focusing on their complementary impact on organizational performance. IntroductIon We live in an age in which the value of information and knowledge has far surpassed that of physical goods. Information resources have become a key differentiator of successful businesses. Information technology (IT) and information systems (IS) are now integrated in almost every aspect of business, from planning to analysis and design, operations management and strategic decision making. Even for those businesses not in information industries, information plays a vital role in supporting their business functions, from routine operations to strategizing. John Naisbitt (1982) theorized that information would be the driving force for organizations. Companies that manage information well are more likely to maintain a competitive advantage against their peers. Because information has become a major force in
Parsing the Behavioral and Brain Mechanisms of Third-Party Punishment

The evolved capacity for third-party punishment is considered crucial to the emergence and maintenance of elaborate human social organization and is central to the modern provision of fairness and justice within society. Although it is well established that the mental state of the offender and the severity of the harm he caused are the two primary predictors of punishment decisions, the precise cognitive and brain mechanisms by which these distinct components are evaluated and integrated into a punishment decision are poorly understood. Using fMRI, here we implement a novel experimental design to functionally dissociate the mechanisms underlying evaluation, integration, and decision that were conflated in previous studies of third-party punishment. Behaviorally, the punishment decision is primarily defined by a superadditive interaction between harm and mental state, with subjects weighing the interaction factor more than the single factors of harm and mental state. On a neural level, evaluation of harms engaged brain areas associated with affective and somatosensory processing, whereas mental state evaluation primarily recruited circuitry involved in mentalization. Harm and mental state evaluations are integrated in medial prefrontal and posterior cingulate structures, with the amygdala acting as a pivotal hub of the interaction between harm and mental state. This integrated information is used by the right dorsolateral prefrontal cortex at the time of the decision to assign an appropriate punishment through a distributed coding system. Together, these findings provide a blueprint of the brain mechanisms by which neutral third parties render punishment decisions. SIGNIFICANCE STATEMENT Punishment undergirds large-scale cooperation and helps dispense criminal justice. Yet it is currently unknown precisely how people assess the mental states of offenders, evaluate the harms they caused, and integrate those two components into a single punishment decision. Using a new design, we isolated these three processes, identifying the distinct brain systems and activities that enable each. Additional findings suggest that the amygdala plays a crucial role in mediating the interaction of mental state and harm information, whereas the dorsolateral prefrontal cortex plays a crucial, final-stage role, both in integrating mental state and harm information and in selecting a suitable punishment amount. These findings deepen our understanding of how punishment decisions are made, which may someday help to improve them.
A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae)

Cayratia trifolia Linn. Domin Syn. Vitis trifolia (Family: Vitaceae) is commonly known as Fox grape in English; Amlabel, Ramchana in Hindi and Amlavetash in Sanskrit. It is native to India, Asia and Australia. It is a perennial climber having trifoliated leaves with 2-3 cm long petioles and ovate to oblong-ovate leaflets. Flowers are small greenish white and brown in color. Fruits are fleshy, juicy, dark purple or black, nearly spherical, about 1 cm in diameter. It is found throughout the hills in India. This perennial climber is also found in the hotter part of India from Jammu and Rajasthan to Assam extending into the peninusular India upto 600 m height. Whole plant of Cayratia trifolia has been reported to contain yellow waxy oil, steroids/terpenoids, flavonoids, tannins upon preliminary phytochemical screening. Leaves contain stilbenes (piceid, reveratrol, viniferin, ampelopsin). Stem, leaves, roots are reported to possess hydrocyanic acid, delphinidin and several flavonoids such as cyanidin is reported in the leaves. This plant also contains kaempferol, myricetin, quercetin, triterpenes and epifriedelanol. Infusion of seeds along with extract of tubers is traditionally given orally to diabetic patients to check sugar level of blood. Paste of tuberous is applied on the affected part in the treatment of snake bite. Whole plant is used as diuretic, in tumors, neuralgia and splenopathy. Its climbers wrapped around the neck of frantic bullock and poultice of leaves are used to yoke sores of bullock. The bark extract shows the antiviral, antibacterial, antiprotozoal, hypoglycemic, anticancer and diuretic activity. This article focuses on the upgraded review on chemical and biological properties of Cayratia trifolia Linn. and triggers further investigation on this plant.
Initiation of Primary Care—Mental Health Integration Programs in the VA Health System: Associations With Psychiatric Diagnoses in Primary Care

Background:Providing collaborative mental health treatment within primary care settings improves depression outcomes and may improve detection of mental disorders. Few studies have assessed the effect of collaborative mental health treatment programs on diagnosis of mental disorders in primary care populations. In 2008, many Department of Veterans Affairs (VA) facilities implemented collaborative care programs, as part of the VA's Primary Care–Mental Health Integration (PC-MHI) program. Objectives:To assess the prevalence of diagnosed mental health conditions among primary care patient populations in association with PC-MHI programs, overall and for patient subpopulations that may be less likely to receive mental health treatment. Research Design:Using a difference-in-differences analysis, we evaluated whether the rates of psychiatric diagnoses among primary care patient populations at 294 VA facilities changed from fiscal year (FY)07 to FY08, and whether trends differed at facilities with PC-MHI encounters in FY08. Subgroup analyses examined whether trends differed by patient age and race/ethnicity. Subjects, Measures, and Results:From FY07 to FY08, the prevalence of diagnosed depression, anxiety, post-traumatic stress disorder, and alcohol abuse increased more in the 137 facilities with PC-MHI program encounters than in the 157 facilities without these encounters. Increases were more likely among patients who were younger (18–64) and white. Conclusions:Initiation of PC-MHI programs was associated with elevated diagnosis patterns, which may enhance recognition of mental health needs among primary care patients. Increases in diagnosis prevalence were not uniform across patient subgroups. Further research is needed on treatment processes and outcomes for individuals receiving services in PC-MHI programs.
Unit Costs of Health and Social Care 2004

This is the twelfth volume of a series designed to improve unit cost estimates over time, drawing on material as it becomes available, including ongoing and specially commissioned research. It brings together information from a variety of sources to estimate national unit costs for a wide range of health and social care services. The costs reported always reflect, to a greater or lesser degree, work in progress, as the intention is to refine and improve estimates wherever possible, drawing on a wide variety of sources. The report consists of sets of ‘schemata’ or tables, which as well as providing the most detailed and comprehensive information possible, also quote sources and assumptions so users can adapt the information for their own purposes. Also included are: an editorial discussing current and new developments; brief articles providing background to user services, descriptions of cost methodology or use of cost estimates; price indices; a reference list of key studies; a glossary; and indexes. New in this edition: This volume includes a considerable expansion of information about the costs of child social care services, based largely on the results of a series of studies commissioned under the Department of Health's Costs and Effectiveness of Services for Children in Need research initiative. Also included is information on the cost-effectiveness of screening and referral to an alcohol health worker in alcohol-misusing patients attending an NHS accident and emergency department. Information about the costs of a nurse practitioner in primary care is also included for the first time. There are five brief articles: description of the methodology used and resulting unit costs of the adoption process and of supporting families; a brief article identifying the processes involved and the costs to social services of carrying out core assessments for children and their families; a description of the processes undertaken by social services and the factors associated with the variation in costs of child care; description of the evaluation of the costs and outcomes of Home-Start — a well-established national and international organisation offering support to families with young children experiencing difficulties; and information about a detailed study of family interventions and the costs of services used by families requiring support.
Dis-Integrating Credit Markets - Diversification, Securitization, and Lending in a Recovery

Using exogenous variation in exposure to hurricanes, this article explores how differently diversified US banks lend during the protracted recovery from a major downturn. Compared to diversified banks, local banks (i) originate a higher share of new mortgage and small business loans in affected areas, but (ii) sell a higher share of the new mortgages into the secondary market. These results suggest a pattern of specialization, whereby loans in affected areas are increasingly originated by banks with special abilities or incentives to seize opportunities in a distressed market, but increasingly transferred to agents which can better support the associated risk.
Genetic disruption of the KLF1 gene to overexpress the γ‐globin gene using the CRISPR/Cas9 system

β‐thalassemia comprises a major group of human genetic disorders involving a decrease in or an end to the normal synthesis of the β‐globin chains of hemoglobin. KLF1 is a key regulatory molecule involved in the γ‐ to β‐globin gene switching process directly inducing the expression of the β‐globin gene and indirectly repressing γ‐globin. The present study aimed to investigate the ability of an engineered CRISPR/Cas9 system with respect to disrupting the KLF1 gene to inhibit the γ‐ to β‐hemoglobin switching process in K562 cells.
The impact of top management support for strategic planning on crisis management: Case study on UNRWA-Gaza strip

The study aims to analyze the impact of top management support for strategic planning on crisis management in UNRWA-Gaza Strip field in Palestine. Several descriptive analytical methods were used for this purpose, and a survey as a tool for data collection. Community size was (881), and the study sample was stratified random (268). The overall findings of the current study show that top management provides needed HR for strategic planning but with no financial support. Also there are shortcomings in the way that organization manages the crises before and after they occur. A crisis management is only practicing during the crisis. The study suggest that top management must provide the financial support for strategic planning, periodic meetings to prepare how to deal with potential crisis in the future, establishing a specialized team and provide them with all sources needed.
Financial development and remittances in RBMU's countries

The aim of this paper is to evaluate the state of development of financial system from 3 of those countries that European Union has established relation through Partnership Program, added Romania also. The research is based on the empirical evidence about the structure and performance of financial systems from RBMU's countries (Romania, Belarus, Ukraine and Moldova). The results are correlated with the influence of remittances inflows in fostering the development of financial systems, especially banking systems, analyzed from the reverse casualty approach.