Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring the Pressure in the Superficial Inferior Epigastric Vein to Monitor for Venous Congestion in Deep Inferior Epigastric Artery Perforator Breast Reconstructions: A Pilot Study

During deep inferior epigastric artery perforator (DIEP) flap dissection, we noted that in many cases the superficial vein on the ipsilateral side of the flap was engorged and tense, and in others, it was empty. This led us to believe that the pressure is increased as the result of preferential outflow through the superficial vein in some cases, which could result in venous congestion of the flap if this vessel was not anastomosed. To test this hypothesis, we measured the venous pressure in the superficial venous system before and after flap dissection. The pressure in the superficial inferior epigastic vein of a DIEP flap was measured in 26 consecutive flaps to investigate the correlation between the pressure and venous congestion of the flap. The first measurement was performed at the beginning of the dissection, and the second measurement was taken after the flap had been completely raised on a single perforator. The mean increase in pressure after flap dissection was 10.6 mm Hg (mu = 10.6; range -1 to 31; O +/- 7.0 mm Hg). Clinical signs of venous congestion were observed in one case. In this case, the increase in venous pressure was with 31 mm Hg, also the highest. Although the results of this report are preliminary, they indicate that the pressure in the superficial vein of DIEP flaps might be of predictive value for venous congestion.
Genetic variation in the G-50T polymorphism of the cytochrome P450 epoxygenase CYP2J2 gene and the risk of younger onset type 2 diabetes among Chinese population: potential interaction with body mass index and family history.

BACKGROUND Cytochrome P450 (CYP) 2J2 is a regulatory enzyme in the biosynthesis of biologically active CIS-epoxyeicosatrienoic acids (EETs). EETs have been suggested to modulate PPAR-gamma and PPAR-alpha transcription activity and play a role in stimulus-secretion coupling in pancreatic beta cells. Genetic abnormalities in the expression of CYP2J enzymes may play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our objective was to investigate CYP2J2 G-50T polymorphism (rs890293) in association with insulin resistance markers and T2DM in a Chinese population. METHODS A total of 1 747 Chinese T2DM patients and 994 non-diabetic subjects were studied. The CYP2J2 G-50T polymorphism was determined by a restriction fragment-length polymorphism polymerase chain reaction. RESULTS Neither the CYP2J2 genotype distribution nor allele frequency differed between the control subjects and the T2DM patients. However, among diabetics, subjects with a younger age at diagnosis (AAD; <40 years) had significantly higher T variant frequency than those with an AAD>/=40 years. When diabetic patients were stratified by their AAD in 10-year intervals, the trend was significantly linear among age grades. A significant interaction between the CYP2J2 T variant and younger onset diabetic subjects with positive family diabetes history, and BMI>/=27 kg/m (2) were observed to have the highest risk of diabetes and younger onset diabetics with the T variant had higher homeostasis model assessment estimate of insulin resistance (HOMA-IR) and HOMA-beta values than their GG genotype counterparts. Plasma concentrations of stable EET metabolites were significantly lower in individuals with the G-50T SNP in younger onset diabetics. CONCLUSION These data suggest that age of onset, family history, and obesity may modify the association between the CYP2J2 G-50T polymorphism and T2DM risk. CYP2J2 G-50T polymorphism may contribute to the pathogenesis of T2DM, partially by effects on insulin resistance, in patients with younger onset T2DM.
Bone Status in Professional Cyclists

Professional cycling combines extensive endurance training with non weight-bearing exercise, two factors often associated with lower bone mineral density (BMD). Therefore BMD was measured with dual-energy x-ray absorptiometry in 30 professional road cyclists (mean (SD) age: 29.1 (3.4) years; height: 178.5 (6.7) cm; weight: 71.3 (6.1) kg; %fat mass: 9.7 (3.2)%; VO (2)max: 70.5 (5.5) ml.kg (-1). min (-1)) and in 30 young healthy males used as reference (28.6 (4.5) years; 176.5 (6.3) cm; 73.4 (7.3) kg; 20.7 (5.8)%). Adjusting for differences in age, height, fat mass, lean body mass, and calcium intake by ANCOVA, professional cyclists had similar head BMD (p=0.383) but lower total body (1.135 (0.071) vs. 1.248 (0.104) g.cm (-2); p<0.001), arms (0.903 (0.075) vs. 0.950 (0.085), p=0.028), legs (1.290 (0.112) vs. 1.479 (0.138); p<0.001), spine (0.948 (0.100) vs. 1.117 (0.147) g.cm (-2); p<0.001), pelvis (1.054 (0.084) vs. 1.244 (0.142), p<0.001), lumbar spine (1.046 (0.103) vs. 1.244 (0.167), P<0.001), and femoral neck BMD (0.900 (0.115) vs. 1.093 (0.137), p<0.001) compared to reference subjects. Professional cycling appears to negatively affect BMD in young healthy and highly active males, the femoral neck being the most affected site (-18%) in spite of the elevated muscle contractions inherent to the activity.
Which older adults maintain benefit from cognitive training? Use of signal detection methods to identify long-term treatment gains

ABSTRACT Background: Cognitive training has been shown to improve memory in older adults; however, little is known about which individuals benefit from or respond best to training in the long term. Identification of responders’ characteristics would help providers match cognitive interventions to individuals to improve their effectiveness. Signal detection methods may prove more informative than more commonly used analytic methods. The goal of the current study is to identify baseline characteristics of long-term treatment responders and of those able to maintain their initial benefit from cognitive training. Methods: Participants were 120 non-demented, community-dwelling older adults who had participated in a cognitive training intervention. Tested predictors included both demographic and neurocognitive variables. Primary outcome variables were performance on measures of memory at one-year follow-up. Results: Results of the signal detection analysis indicated that different neurocognitive performances predicted long-term effects of memory training and maintenance of initial treatment response according to different types of to-be-remembered material. Higher baseline scores on tests of associative memory, delayed verbal memory, attention, episodic memory, and younger age were found predictive of long-term response one year later. Higher associative memory scores and lower initial gains at the end of treatment (week 14) predicted successful maintenance of training gains at week 52. Conclusions: To derive long-term benefit from particular cognitive training programs, it appears necessary for older adults to have specific neurocognitive profiles. Further, inclusion of booster sessions to cognitive training programs may assist in maintenance of initial treatment gains.
Comorbid cardiovascular disease and major depression among ethnic and racial groups in the United States

ABSTRACT Background: To describe and examine the distribution, disability, and treatment associated with comorbid cardiovascular disease and major depressive disorder (CVD/MDD) among middle-aged and older ethnic/racial groups in the United States. Methods: Cross-sectional data from a national probability sample of household resident adults (18 years and older; N = 16,423) living in the 48 coterminous United States were analyzed. We defined comorbid CVD/MDD as the presence of CVD (e.g. diabetes, hypertension, heart disease, and stroke) among adults who met MDD criteria at or after age 50 years. Results: Two-thirds of middle-aged and older American adults meeting criteria major depression at or after age 50 years also reported a diagnosis of comorbid CVD. Blacks were most likely to meet our comorbid CVD/MDD (74.4%) criteria. The disease burden of depression was also highest among Black respondents. Differences in treatment due to race/ethnicity and comorbidity were not statistically significant. Conclusions: Our findings indicate that among middle-aged and older US adults meeting MDD criteria more than half would also report a comorbid CVD. Comorbid CVD/MDD rates varied between the considered ethnic/race groups. Functional impairment associated with comorbid CVD/MDD was higher than MDD alone; however, depression care rates did not differ remarkably. Among middle-aged and older adults meeting MDD criteria, comorbid CVD may be the rule rather than the exception.
Transferable wavelet method for grain‐size distribution from images of sediment surfaces and thin sections, and other natural granular patterns

In images of sedimentary or granular material, or simulations of binary (two‐phase) granular media, in which the individual grains are resolved, the complete size distribution of apparent grain axes is well‐approximated by the global power spectral density function derived using a Morlet wavelet. This approach overcomes many limitations of previous automated methods for estimating the grain‐size distribution from images, all of which rely on either: identification and segmentation of individual grains; calibration and/or relatively large sample sizes. The new method presented here is tested using: (i) various types of simulations of two‐phase media with a size distribution, with and without preferred orientation; (ii) 300 sample images drawn from 46 populations of sands and gravels from around the world, displaying a wide variability in origin (biogenic and mineralogical), size, surface texture and shape; (iii) petrographic thin section samples from nine populations of sedimentary rock; (iv) high‐resolution scans of marine sediment cores; and (v) non‐sedimentary natural granular patterns including sea ice and patterned ground. The grain‐size distribution obtained is equivalent to the distribution of apparent intermediate grain diameters, grid by number style. For images containing sufficient well‐resolved grains, root mean square errors are within tens of percent for percentiles across the entire grain‐size distribution. As such, this method is the first of its type which is completely transferable, unmodified, without calibration, for both consolidated and unconsolidated sediment, isotropic and anisotropic two‐phase media, and even non‐sedimentary granular patterns. The success of the wavelet approach is due, in part, to it quantifying both spectral and spatial information from the sediment image simultaneously, something which no previously developed technique is able to do.
Social networking sites and older users – a systematic review

ABSTRACT Background: Social networking sites can be beneficial for senior citizens to promote social participation and to enhance intergenerational communication. Particularly for older adults with impaired mobility, social networking sites can help them to connect with family members and other active social networking users. The aim of this systematic review is to give an overview of existing scientific literature on social networking in older users. Methods: Computerized databases were searched and 105 articles were identified and screened using exclusion criteria. After exclusion of 87 articles, 18 articles were included, reviewed, classified, and the key findings were extracted. Common findings are identified and critically discussed and possible future research directions are outlined. Results: The main benefit of using social networking sites for older adults is to enter in an intergenerational communication with younger family members (children and grandchildren) that is appreciated by both sides. Identified barriers are privacy concerns, technical difficulties and the fact that current Web design does not take the needs of older users into account. Conclusions: Under the conditions that these problems are carefully addressed, social networking sites have the potential to support today's and tomorrow's communication between older and younger family members.
High Prevalence of Intracranial Meningioma in Jewish Population in Shiraz, Southern Iran

BackgroundThere are few well-established causes of intracranial tumors of the brain and nervous system among adults, and investigators have looked to associations between incidence and sociodemographic variables for clues to etiology. In this study, we tried to evaluate the relative risk of meningioma in the Shiraz Jewish population, to assess possible genetic issues with meningioma. Patients and MethodsA historical cohort study of adult intracranial meningioma was conducted in 2008 at 5 hospitals in Shiraz. Religion was recorded on admission in patients' charts, while an interview was conducted with every patient. To minimize the chance of missing even 1 Jewish patient, we contacted a few well-trusted Jewish family physicians. Chi square test was used to calculate relative risks. ResultsThe Shiraz population in the aforementioned period of time was approximately 1,255,955, and mean Jewish population was 5784. There were 356 non-Jewish and 15 Jewish cases with intracranial meningioma. The relative risk for development of meningioma in Jewish population was 9.10 (95% CI: 4.81-14.01; P<0.01). The prevalence of meningioma in Jewish population in our series was 259 (95% CI: 128-390) per 100,000 population. ConclusionsOur study showed an increased risk of intracranial meningioma among those of Jewish race in this specific region. Meningioma risk was elevated almost 9-fold among Jewish residents of the city of Shiraz. Clearly established environmental risk factors were not found to cause such a higher risk in this study. Our findings indicate the influence of genetic factors in the higher risk for meningioma among jews.
Interleukin‐10 Gene Promoter and NFKB1 Promoter Insertion/Deletion Polymorphisms in Systemic Sclerosis

Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrotic, immunological and vascular abnormalities. Nuclear factor‐kB (NFKB), as a key transcription factor involved in the regulation of immune responses, appears to be a good candidate for studies on the pathogenesis of autoimmune diseases, as well as the interleukin‐10 (IL‐10) polymorphism, which other studies have suggested an association with SSc. Our objective was to study the association of NFKB and IL‐10 gene polymorphisms with SSc. One hundred and fifty‐one SSc patients and 147 healthy bone marrow donors were enrolled in a case–control study. Blood was collected for DNA extraction; typing of IL‐10 genes was made by polymerase chain reaction with sequence‐specific primers (PCR–SSP), and NFKB gene typing was made by restriction fragment length polymorphism (RFLP). Patients underwent clinical evaluation, serology, Doppler echocardiography and chest high‐resolution computed tomography. The frequency of IL‐10 (−1082) GG genotype was found to be significantly higher in SSc patients (36.4%) as compared to healthy controls (22.4%) (P = 0.012). The frequency of heterozygous genotype GA was significantly lower (P = 0.004) in patients (38.4%) in comparison with control subjects (55.8%). A predominance of the high‐producing IL‐10 phenotype (GCC+/GCC+) was observed in SSc patients compared with healthy controls (37.7% versus 24.5%, respectively; OR: 1.87, 95% CI: 1.10–3.19, P = 0.019). No significant difference was found in the allelic and genotype distribution of the NFKB promoter polymorphism between patients and controls. No statistically significant associations were found between IL‐10 or NFKB polymorphisms clinical and laboratory features of SSc. Our results confirmed the association of the high‐producing phenotype (GCC+/GCC+) with increased risk for SSc, but found no correlation with NFKB polymorphisms.
Diagnostic Yield of Heat Shock Protein 70 (HSP‐70) and Anti‐HSP‐70 in Behcet‐Induced Uveitis

Heat shock proteins (HSPs) are intracellular proteins with pro‐ and anti‐inflammatory actions, playing an important role in the pathogenesis of Behcet's disease (BD). Diagnosis of BD uveitis in early stages is still problematic, thus this study was undertaken to determine diagnostic values of serum HSP‐ and anti‐HSP‐70 in BD uveitis. Serum levels of HSP‐ and anti‐HSP‐70 were measured in 53 patients with BD (26 with and 27 without uveitis). In control group, 25 age‐ and sex‐matched idiopathic uveitis patients were enrolled consecutively. Both groups had no medical problems save uveitis at the time of sampling. Confounders like medications were analysed subsequently. HSP‐ and anti‐HSP‐70 values were measured by commercial ELISA kits. Data were analysed by spss 11.5 and medcalc 11.5. 1 software. The Mean HSP‐70 serum levels were different among aforementioned subgroups (P = 0.001, anova). They were elevated in BD uveitis compared with BD without uveitis (4.84 ± 4.21 versus 2.24 ± 2.08 ng/ml; P = 0.045). HSP‐70 in sera of BD uveitis was also higher than that parameter in patients with idiopathic uveitis (4.84 ± 4.21 versus 2.37 ± 3.30 ng/ml; P = 0.001; cut‐off point value 1.0 9 ng/ml, 95% CI 0.61–0.86, P = 0.0002, ß = 0.06). However, there was not any statistical difference among those groups in the serum anti‐HSP‐70 levels (P = 0.63, anova). Multiple regression analysis demonstrated that among different confounders, only prednisolone increases and BD uveitis decreases HSP‐70 levels independently. This prospective cross‐sectional study suggested that HSP‐70 serum level is impressed over the course of BD uveitis, and it could be utilized to diagnose or predict developing it.
Approaches to Noise Reduction in Analog, Digital, and Hybrid Hearing Aids

Reprint requests: Dr. Preves, Argosy Electronics, Research and Development Department, 10300 West 70th Street Eden Prairie, MN 55459. Although the effectiveness of hearing aid fittings continues to improve as knowledge of hearing aid design and evaluation increases, several major problems still exist. The inability of most hearing aids to deal effectively with difficult message/ competition environments, such as cafeterias, cocktail parties, and church basements, is especially problematical for the hearing impaired. Persons with sensorineural auditory pathology are very susceptible to both an upward spread of masking on the basilar membrane from low-frequency environmental noise and to masking from distortion components produced by the hearing aid itself in high noise level background environments. 5 These latter distortion components arise due to inadequate "headroom" (a condition resulting from low saturation sound pressure level (SSPL 90) combined with high gain causing clipping at high-input levels). Distortion components produced by hearing aids with inadequate headroom are thought to cause subjective judgments of poor sound quality and poor speech clarity by hearing aid wearers. In a study of perceived sound quality with 12 hearing-impaired persons listening to hearing aid processed sound, clarity was found to be the parameter most highly correlated to total impression of the hearing aid. Another related study found that good sound quality was ranked as the most important property of hearing aids by 43 of 49 hearing-impaired patients and clarity was the most important sound quality dimension. Negative judgments of poor sound quality often lead to nonacceptance: hearing aid wearers turning their hearing aids off in noisy backgrounds or not wearing them at all. There are many technical innovations that have been emerging recently for improving hearing aid performance. In the last 5 years, hearing aids have perhaps experienced a more rapid technological evolution than in any similar period of time. Developments in low voltage integrated circuit technology by semiconductor companies have made it possible for hearing aid designers to incorporate important performance features into analog hearing aids never used before. At the same time, hybrid analog-digital and even
The stages of driving cessation for people with dementia: needs and challenges

ABSTRACT Background: The impact of dementia on safe driving is well recognized and is generally accepted that all people with dementia are likely to need to cease driving at some stage in the disease process. Both driving and driving cessation can have poor outcomes for people with dementia and their caregivers in terms of health, safety, community access, and well-being. Although approaches to facilitate better outcomes from driving cessation are being developed, the processes of driving cessation for people with dementia are still not fully understood. Methods: Within a descriptive phenomenological framework, semi-structured interviews were undertaken with key stakeholders, including retired drivers with dementia, family members, and health professionals. Results: Findings from four retired drivers with dementia, 11 caregivers, and 15 health professionals characterized driving cessation for people with dementia as a process with three stages and associated challenges and needs. The early stage involved worried waiting, balancing safety with impending losses, and the challenge of knowing when to stop. The crisis stage involved risky driving or difficult transportation, acute adjustment to cessation and life without driving, and relationship conflict. The post-cessation stage was described as a long journey with ongoing battles and adjustments as well as decreased life space, and was affected by the disease progression and the exhaustion of caregiver. Conclusions: The concept of stages of driving cessation for people with dementia could be used to develop new approaches or adapt existing approaches to driving cessation. Interventions would need to be individualized, optimally timed, and address grief, explore realistic alternative community access, and simultaneously maintain key relationships and provide caregiver support.
Are polymorphisms of the β3‐adrenoceptor gene associated with an altered bladder function?

As the presence of a Trp64Arg polymorphism of the gene encoding the β3‐adrenoceptor (B3AR) has been linked to the presence of overactive bladder, we investigated whether additional polymorphisms are detectable in this gene and explore their relationships parameters related to lower urinary tract function.
Substance use behaviors of secondary school students in post-conflict Liberia: a pilot study

In this study we sought to determine the prevalence of substance use among students in Monrovia, Liberia, in order to better characterize the extent of the problem and guide future research. We conducted a cross-sectional survey to examine the substance use behaviors of students in 16 secondary schools in greater and central Monrovia, Liberia. The sampling frame included all co-educational secondary schools in central and greater Monrovia. A total of 802 students completed the questionnaire. The mean age was 19±3 years. Alcohol was the most commonly used substance, with 51% (399) of respondents reporting using it. Additionally, 9% of all students reported marijuana consumption. Older respondents were more likely to have ever used marijuana. Men were more likely than women to ever consume marijuana and smoke cigarettes. There were no significant differences in gender or age for other drug use. Research has shown that younger people who consume alcohol are more likely to engage in high-risk behavior, such as unprotected sex, early sex or sex with multiple partners, than others their age. Given that the majority of our respondents reported first consuming alcohol before 18 years of age, drug prevention campaigns need to target younger adolescents.