Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia

Dasatinib, a second-generation BCR-ABL1 tyrosine kinase inhibitor, is approved for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, both as first-line therapy and after imatinib intolerance or resistance. While generally well tolerated, dasatinib has been associated with a higher risk for pleural effusions. Frequency, risk factors, and outcomes associated with pleural effusion were assessed in two phase 3 trials (DASISION and 034/Dose-optimization) and a pooled population of 11 trials that evaluated patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia treated with dasatinib (including DASISION and 034/Dose-optimization). In this largest assessment of patients across the dasatinib clinical trial program (N=2712), pleural effusion developed in 6-9% of patients at risk annually in DASISION, and in 5-15% of patients at risk annually in 034/Dose-optimization. With a minimum follow up of 5 and 7 years, drug-related pleural effusion occurred in 28% of patients in DASISION and in 33% of patients in 034/Dose-optimization, respectively. A significant risk factor identified for developing pleural effusion by a multivariate analysis was age. We found that overall responses to dasatinib, progression-free survival, and overall survival were similar in patients who developed pleural effusion and in patients who did not. clinicaltrials.gov identifier 00481247; 00123474.
Viability of Descemet Membrane Endothelial Keratoplasty Grafts Folded in the Eye Bank

Purpose: Preloaded, trifolded grafts in Descemet membrane endothelial keratoplasty require transfer of the trifolding process from the corneal transplant surgeon to the eye bank technician. We sought to assess whether trifolding may be safely conducted by an eye bank technician with cell loss comparable to standard peeling and lifting. Methods: A total of 10 grafts were stained, peeled, and transferred directly onto a bed of Calcein-AM and Amvisc Plus by an eye bank technician. Five grafts were removed and stained as a scroll, and 5 grafts were trifolded with the endothelium in before transfer. Photographs were acquired with an inverted fluorescence microscope, and image segmentation was performed. A t test was conducted to compare differences in endothelial cell loss across groups. Results: Mean cell loss in the scroll group was 18.5% [95% confidence interval (CI): 15.2%–21.9%] compared with 7.6% of the trifolded group (95% CI: 1.7%–13.5%). A 2-tailed t test indicated decreased cell loss in the trifolded group (P = 0.013). Conclusions: Despite additional manipulation of the graft, trifolding of Descemet membrane and endothelium may be performed by an eye bank technician without significantly increased cell loss relative to graft preparation as a scroll.
Fixed versus Growth Mindset Does not Seem to Matter Much: A Prospective Observational Study in Two Late Bachelor level Computer Science Courses

Psychology predicts that a student's mindset---their implicit theory of intelligence---has an effect on their academic performance. We attempted to corroborate this in the computer science education context by asking the students on two bachelor-level courses, typically taken in the third year of studies, to fill out a standard mindset questionnaire, and analyzing their answers in relation to their grades on those courses. In a sample of 133 students, with only 24 (18 %) students with a clear fixed mindset, there is no detectable correlation between the students' mindsets and their course grades. An ordinal logistic regression estimates, at the 95~% confidence level, a statistically nonsignificant effect between a decrease by a factor of 0.46 and an increase by a factor of 2.03 in the odds of achieving a better course grade when moving from a strong fixed mindset to neutral mindset, or when moving from a moderate fixed mindset to a moderate growth mindset. This suggests that any effect the mindset has on the outcomes of these courses is small. We conclude that educational interventions targeting students' mindsets may not be worth the effort in late bachelor-level CS education, possibly because students who suffer from their fixed mindset have already dropped out by the third year.
Issues and Suggestions for the Development of a Biodiversity Data Visualization Support Tool

Visualizations are an important tool to transport information. However, ﬁ nding the right visualization can be challenging. Using the biodiversity research domain as a showcase, we investigate where exactly these challenges are and what a tool should look like that helps scientists overcome them. Our results are based on a survey we performed. Categories and Subject Descriptors (according to ACM CCS) : A.1 [Computer Graphics]: General Literature—Introductory and Survey (see http://www.acm.org/about/class/class/2012)
The Very Efficient Assessment of Need for Cognition: Developing a Six-Item Version

The need for cognition refers to people’s tendency to engage in and enjoy thinking and has become influential across social and medical sciences. Using three samples from the United States and the United Kingdom (N = 1,596), we introduce a six-item short version of the Need for Cognition Scale (NCS-18). First, we reduced the number of items from 18 to 6 based on the items’ discrimination values, threshold levels, measurement precision (item information curve), item–total correlations, and factor loadings. Second, we confirmed the one-factor structure and established measurement invariance across countries and gender. Finally, we demonstrated that while the NCS-6 provides significant time savings, it comes at a minimal cost in terms of its construct validity with external variables such as openness, cognitive reflection test, and need for affect. Overall, our findings indicate that the NCS-6 is a parsimonious, reliable, and valid measure of need for cognition.
Magnetic Resonance Imaging Parameters at 1 Year Correlate With Clinical Outcomes Up to 17 Years After Autologous Chondrocyte Implantation

Background: The ability to predict the long-term success of surgical treatment in orthopaedics is invaluable, particularly in clinical trials. The quality of repair tissue formed 1 year after autologous chondrocyte implantation (ACI) in the knee was analyzed and compared with clinical outcomes over time. Hypothesis: Better quality repair tissue and a better appearance on magnetic resonance imaging (MRI) 1 year after ACI lead to improved longer-term clinical outcomes. Study Design: Cohort study; Level of evidence, 3. Methods: Repair tissue quality was assessed using either MRI (11.5 ± 1.4 [n = 91] or 39.2 ± 18.5 [n = 76] months after ACI) or histology (16.3 ± 11.0 months [n = 102] after ACI). MRI scans were scored using the whole-organ magnetic resonance imaging score (WORMS) and the magnetic resonance observation of cartilage repair tissue (MOCART) score, with additional assessments of subchondral bone marrow and cysts. Histology of repair tissue was performed using the Oswestry cartilage score (OsScore) and the International Cartilage Repair Society (ICRS) II score. Clinical outcomes were assessed using the modified Lysholm score preoperatively, at the time of MRI or biopsy, and at a mean 8.4 ± 3.7 years (maximum, 17.8 years) after ACI. Results: At 12 months, the total MOCART score and some of its individual parameters correlated significantly with clinical outcomes. The degree of defect fill, overall signal intensity, and surface of repair tissue at 12 months also significantly correlated with longer-term outcomes. The presence of cysts or effusion (WORMS) significantly correlated with clinical outcomes at 12 months, while the presence of synovial cysts/bursae preoperatively or the absence of loose bodies at 12 months correlated significantly with long-term clinical outcomes. Thirty percent of repair tissue biopsies contained hyaline cartilage, 65% contained fibrocartilage, and 5% contained fibrous tissue. Despite no correlation between the histological scores and clinical outcomes at the time of biopsy, a lack of hyaline cartilage or poor basal integration was associated with increased pain; adhesions visible on MRI also correlated with significantly better histological scores. Conclusion: These results demonstrate that MRI at 12 months can predict longer-term clinical outcomes after ACI. Further investigation regarding the presence of cysts, effusion, and adhesions and their relationship with histological and clinical outcomes may yield new insights into the mechanisms of cartilage repair and potential sources of pain.
Breakdown of the Wiedemann–Franz law in a unitary Fermi gas

Significance Heat and matter currents are required to relax an out-of-equilibrium system with temperature and chemical potential gradients to thermodynamical equilibrium. The ratio of heat to particle conductance characterizes this response and takes a universal value for typical electronic materials, known as the Wiedemann–Franz law, originating in the quasi-particle nature of the excitations contributing to transport. Investigating the transport dynamics between two reservoirs of ultracold and strongly interacting Fermi gases, connected by a quantum point contact, we observe a nonequilibrium steady state, strongly violating the Wiedemann–Franz law. This cold atom version of the fountain effect, previously observed in superfluid helium superleaks, is characterized by a weak coupling between heat and particle currents that results in a nonvanishing Seebeck coefficient. We report on coupled heat and particle transport measurements through a quantum point contact (QPC) connecting two reservoirs of resonantly interacting, finite temperature Fermi gases. After heating one of them, we observe a particle current flowing from cold to hot. We monitor the temperature evolution of the reservoirs and find that the system evolves after an initial response into a nonequilibrium steady state with finite temperature and chemical potential differences across the QPC. In this state any relaxation in the form of heat and particle currents vanishes. From our measurements we extract the transport coefficients of the QPC and deduce a Lorenz number violating the Wiedemann–Franz law by one order of magnitude, a characteristic persisting even for a wide contact. In contrast, the Seebeck coefficient takes a value close to that expected for a noninteracting Fermi gas and shows a smooth decrease as the atom density close to the QPC is increased beyond the superfluid transition. Our work represents a fermionic analog of the fountain effect observed with superfluid helium and poses challenges for microscopic modeling of the finite temperature dynamics of the unitary Fermi gas.
Research trends in mothers' health information seeking behaviors: A review of the literature

This study aims to identify and examine research trends relating to mothers' health information seeking behaviors from 1994 to August 2015. Eighty‐seven articles from multiple disciplines were selected systematically and reviewed in diverse aspects: characteristics of the articles, use of theories, information sources, and seeking strategies. This research topic has been given numerous attention since 1994. In particular, the number of publications skyrocketed since 2013. Twenty‐two different theories and models have been utilized in examining mothers' health information seeking behaviors. Furthermore, four seeking strategies of mothers were recognized as asking questions, utilizing multiple sources, borrowing medical literature from libraries, and sharing experiences with friends. Implications for future research in this topic are discussed.
Improved differentiation between high- and low-grade gliomas by combining dual-energy CT analysis and perfusion CT

Abstract The purpose of this study was to investigate the value of the cerebral blood volume (CBV) obtained with perfusion computed tomography (CT) and the electron density (ED) measured by dual-energy CT for differentiating high- from low-grade glioma (HGG, LGG). The CBV and ED were obtained in 9 LGG and 7 HGG patients. The CBV and ED of LGGs and HGGs were compared. Receiver operating characteristic (ROC) curves were generated for CBV, ED, and CBV plus ED. The correlation between CBV, ED, and the MIB-1 labeling index of the tumors was examined. All of these analyses were also performed using relative CBV (rCBV) and ED (rED) (the value of tumors/the value of contralateral white matter). The mean CBV, ED, rCBV, and rED values were significantly higher in HGG than LGG (P < .05). By ROC analysis, the combination of rCBV plus rED as well as CBV plus ED were more accurate than CBV, ED, rCBV, rED alone. There was a significant correlation between ED and MIB-1 (P = .04). ED improved diagnostic accuracy of perfusion CT for differentiating HGG from LGG.
Protein and bone health across the lifespan

Bone health is determined by the rate of accrual in early life, followed by the rate of age-associated bone loss. Dietary protein intake might have a role in bone health across both of these phases via pleiotropic mechanistic pathways. Herein we summarise the pathways through which protein may exert either a positive or negative influence on bone. In the introduction, we describe the acid-ash hypothesis, which states that a high-protein intake may lead to an acidic residue that must be neutralised through the leaching of calcium and other minerals from the bone, subsequently leading to demineralisation and bone weakening. Conversely, and as described in the ‘Against: mechanisms through which protein may negatively impact bone’ section, protein intake may act to strengthen the bone by stimulating the activity of various anabolic hormones and growth factors, or by optimising muscle mass and functionality, which itself has an osteogenic influence. The net effect of these contrasting pathways is described in the ‘For: mechanisms through which protein may positively impact bone’ section, where a number of meta-analyses have demonstrated that higher protein intakes have a small positive impact on bone mass and fracture risk. Sometimes higher than recommended protein intakes are advised, e.g. during the earlier and later phases of the lifespan or during reduced energy availability. We conclude that protein is an essential nutrient for bone health, although further research is required to clarify the mechanistic pathways through which it exerts its influence, along with the clarification of the quantities, food sources and timing to allow for the optimisation of this protective influence and ultimately a reduction in fracture risk.
Assisted gene expression‐based clustering with AWNCut

In the research on complex diseases, gene expression (GE) data have been extensively used for clustering samples. The clusters so generated can serve as the basis for disease subtype identification, risk stratification, and many other purposes. With the small sample sizes of genetic profiling studies and noisy nature of GE data, clustering analysis results are often unsatisfactory. In the most recent studies, a prominent trend is to conduct multidimensional profiling, which collects data on GEs and their regulators (copy number alterations, microRNAs, methylation, etc.) on the same subjects. With the regulation relationships, regulators contain important information on the properties of GEs. We develop a novel assisted clustering method, which effectively uses regulator information to improve clustering analysis using GE data. To account for the fact that not all GEs are informative, we propose a weighted strategy, where the weights are determined data‐dependently and can discriminate informative GEs from noises. The proposed method is built on the NCut technique and effectively realized using a simulated annealing algorithm. Simulations demonstrate that it can well outperform multiple direct competitors. In the analysis of TCGA cutaneous melanoma and lung adenocarcinoma data, biologically sensible findings different from the alternatives are made.
Triplet Chemotherapy (FOLFOXIRI) Plus Bevacizumab Versus Doublet Chemotherapy (FOLFOX/FOLFIRI) Plus Bevacizumab in Conversion Therapy for Metastatic Colorectal Cancer: a Meta-Analysis

Background/Aims: Conversion therapy can convert unresectable metastatic colorectal cancer (mCRC) into resectable. However, the optimal conversion regimen was not yet defined. This meta-analysis aimed to compare the efficacy and safety of the triplet chemotherapy (FOLFOXIRI) plus bevacizumab (Bev) with doublet chemotherapy (FOLFOX/FOLFIRI) plus Bev in conversion therapy. Methods: Randomized controlled trials (RCTs) from databases, including Pubmed, EMBASE, Cochrane clinical trials, clinicaltrial.gov and some conferences, were searched from the inception to November 2017. The R0 resection, objective response rate (ORR), progression-free survival (PFS), overall survival (OS) and the incidence of adverse events were pooled with the use of hazard ratio (HR) or risk ratio (RR). Results: Four RCTs with 1013 patients were included. FOLFOXIRI plus Bev regimen significantly improved the overall R0 resection rate (RR 1.41, 95% confidence interval (CI) 1.07-1.85, I2=37%), liver R0 resection rate (RR 2.28, 95% CI 1.34-3.89, I2=0%), ORR (RR 1.20, 95% CI 1.09-1.32, I2=0%), PFS (HR 0.72, 95% CI 0.62-0.84, I2=36%) and OS (HR 0.80, 95% CI 0.66-0.97, I2=0%). There was no significant difference in any Grade≥3 adverse event (RR 1.08, 95% CI 0.99-1.17, I2=0%) between two regimens. FOLFOXIRI-Bev was associated with a higher risk of neutropenia (RR 1.77, 95% CI 1.13-2.79, I2=68%) and diarrhea (RR 1.65, 95% CI 1.17-2.32, I2=0%). Conclusions: Triplet chemotherapy plus Bev significantly improved the R0 resection rates, ORR, PFS and OS in comparison with doublet chemotherapy plus Bev in conversion therapy for mCRC patients, with a higher risk of neutropenia and diarrhea.
Reciprocal Regulation Between Smad7 and Sirt1 in the Gut

In inflammatory bowel disease (IBD) mucosa, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine transforming growth factor-β1, due to post-transcriptional mechanisms that enhance Smad7 acetylation status thus preventing ubiquitination-mediated proteosomal degradation of the protein. IBD-related inflammation is also marked by defective expression of Sirt1, a class III NAD+-dependent deacetylase, which promotes ubiquitination-mediated proteosomal degradation of various intracellular proteins and triggers anti-inflammatory signals. The aim of our study was to determine whether, in IBD, there is a reciprocal regulation between Smad7 and Sirt1. Smad7 and Sirt1 were examined in mucosal samples of IBD patients and normal controls by Western blotting and immunohistochemistry, and Sirt1 activity was assessed by a fluorimetric assay. To determine whether Smad7 is regulated by Sirt1, normal or IBD lamina propria mononuclear cells (LPMC) were cultured with either Sirt1 inhibitor (Ex527) or activator (Cay10591), respectively. To determine whether Smad7 controls Sirt1 expression, ex vivo organ cultures of IBD mucosal explants were treated with Smad7 sense or antisense oligonucleotide. Moreover, Sirt1 expression was evaluated in LPMC isolated from Smad7-transgenic mice given dextran sulfate sodium (DSS). Upregulation of Smad7 was seen in both the epithelial and lamina propria compartments of IBD patients and this associated with reduced expression and activity of Sirt1. Activation of Sirt1 in IBD LPMC with Cay10591 reduced acetylation and enhanced ubiquitination-driven proteasomal-mediated degradation of Smad7, while inhibition of Sirt1 activation in normal LPMC with Ex527 increased Smad7 expression. Knockdown of Smad7 in IBD mucosal explants enhanced Sirt1 expression, thus suggesting a negative effect of Smad7 on Sirt1 induction. Consistently, mucosal T cells of Smad7-transgenic mice contained reduced levels of Sirt1, a defect that was amplified by induction of DSS colitis. The data suggest the existence of a reciprocal regulatory mechanism between Smad7 and Sirt1, which could contribute to amplify inflammatory signals in the gut.
Mapping the Spatiotemporal Evolution of Emotional Processing: An MEG Study Across Arousal and Valence Dimensions

Electrophysiological and functional neuroimaging findings indicate that the neural mechanisms underlying the processing of emotional dimensions (i.e., valence, arousal) constitute a spatially and temporally distributed emotional network, modulated by the arousal and/or valence of the emotional stimuli. We examined the time course and source distribution of gamma time-locked magnetoencephalographic activity in response to a series of emotional stimuli viewed by healthy adults. We used a beamformer and a sliding window analysis to generate a succession of spatial maps of event-related brain responses across distinct levels of valence (pleasant/unpleasant) and arousal (high/low) in 30–100 Hz. Our results show parallel emotion-related responses along specific temporal windows involving mainly dissociable neural pathways for valence and arousal during emotional picture processing. Pleasant valence was localized in the left inferior frontal gyrus, while unpleasant valence in the right occipital gyrus, the precuneus, and the left caudate nucleus. High arousal was processed by the left orbitofrontal cortex, amygdala, and inferior frontal gyrus, as well as the right middle temporal gyrus, inferior parietal lobule, and occipital gyrus. Pleasant by high arousal interaction was localized in the left inferior and superior frontal gyrus, as well as the right caudate nucleus, putamen, and gyrus rectus. Unpleasant by high arousal interaction was processed by the right superior parietal gyrus. Valence was prioritized (onset at ∼60 ms) to all other effects, while pleasant valence was short lived in comparison to unpleasant valence (offsets at ∼110 and ∼320 ms, respectively). Both arousal and valence × arousal interactions emerged relatively early (onset at ∼150 ms, and ∼170 ms, respectively). Our findings support the notion that brain regions differentiate between valence and arousal, and demonstrate, for the first time, that these brain regions may also respond to distinct combinations of these two dimensions within specific time windows.
Age and burnout syndrome in nursing professionals: moderating role of emotion-focused coping

ABSTRACT This study examined whether the association between age and the three burnout dimensions (emotional exhaustion, depersonalisation and reduced personal accomplishment) depend on the extent of nursing professionals’ use of emotion-focused coping strategy. Participants were 283 nurses (Mage = 35 years, SD = 8.17, Range = 23–66 years) from a tertiary healthcare institution in south-eastern Nigeria. They completed self-report measures of relevant variables in paper and pencil form. Increased age was associated with reduced personal accomplishment for nurses with high emotion-focused coping, but not for those who were low or moderate in use of emotion-focused coping. Such moderation effects were not found for emotional exhaustion and depersonalisation. Findings clarify the conditions under which age may be associated with reduced sense of achievement at work among nursing professionals. The study adds to knowledge in combating burnout in nursing and could guide health managers in developing strategies that might prevent or ameliorate nurses’ burnout.