Miracle-dz/UniFAR-FTUs huggingface dataset:
Erythropoietin exerts a neuroprotective function against glutamate neurotoxicity in experimental diabetic retina.

PURPOSE Retinal neuronal cell dysfunction and even cell death are associated with increased excitotoxic glutamate (Glu) level in the retina. Our aim was to study a causative mechanism of Glu on retinal cell death and explore the neuroprotective role of erythropoietin (EPO) against Glu neurotoxicity in the diabetic retina. METHODS Male Sprague-Dawley (SD) rats and R28 cell line were employed in this study. Diabetes was induced with intraperitoneal injection of streptozotocin (STZ) in SD rats. Two weeks after diabetes onset, the intravitreal injection was performed; 4 days later, the retinas were harvested for testing. R28 cells were treated with Glu, Glu+EPO, or Glu+EPO+soluble EPO receptor (sEPOR), respectively, for 24 hours, and then the cells were collected for the following studies. Glutamate level in the retina was measured with a glutamate assay kit. Cell death was determined with TUNEL staining. The changes in glutamine synthetase (GS), glutamate-aspartate transporter (GLAST), ionotropic glutamate receptors (iGluRs), apoptosis-inducing factor (AIF), and poly(ADP-ribose) (PAR) polymer were studied with RT-PCR, Western blot, and immunofluorescence. RESULTS In 2-week diabetic rat retinas, Glu concentration was approximately 1.21-fold that in normal control. TUNEL staining demonstrated that retinal cell death was increased. Retinal GS and GLAST expressions were decreased, while the iGluRs, for example, KA1 and NR1, and PAR polymer expression was increased. In R28 cells, 24 hours after Glu (10 mM) treatment, the cell viability was decreased by 52.7%; KA1, NR1, PAR polymer, and nuclear AIF all increased in expression. The above conditions could be largely reversed by EPO both in vivo and in vitro. The protective effect of EPO was abolished by sEPOR. CONCLUSIONS Erythropoietin showed a neuroprotective function against Glu-mediated neurotoxicity both in diabetic rat retina and in Glu-treated R28 cells. The neuroprotective mechanisms were largely through maintaining the normal expression of glutamate-glutamine cycle-related proteins and inhibiting AIF translocation and PAR polymer formation.
The Use of Nutritional Labels by College Students in a Food-Court Setting

Objective: Between January and September 2006, the authors examined when, why, if, and how nutrition labels impact food purchase decisions of college students. Participants: Participants were 16 college-aged students at a large northeastern university. Methods: As part of a larger study undertaken at a large northeastern university on the effect of nutrition labels in restaurant settings on food purchases, the authors held a focus group to look more deeply at when and why nutrition labeling impacted college student food purchases. Results: Although results of the large study are still being discerned, the focus group results reveal that college women and men were interested in the provision of nutrition labels in the food court-like setting found at the university, and that those exposed to labels over the course of the study noticed these labels and often referred to them when making purchase decisions. Additional findings reveal that price and convenience also play a role in food purchases and that, of those items listed on each label, calories and fat were most important to the study population. Conclusions: Although more research is needed, this qualitative study finds that students want nutrition labels and would use them to make food purchasing decisions.
Bringing the Wisdom of the Crowd to an Individual by Having the Individual Assume Different Roles

Groups of people tend to generate more diverse ideas than individuals because each group member brings a different perspective to the table. But while someone working alone can suffer from fixation and have difficulty of thinking outside-the-box, in this paper we show that it is possible to help them think more like a group by asking them to approach a problem from different perspectives. We present a study of 54 crowd workers in which some individual workers were asked to assume the role of various relevant experts while solving a problem. We find that participants who were asked to assume different roles came up with more creative ideas than those who were not. These findings suggest there is an opportunity for problem solving tools to bring the wisdom of the crowd to individuals.
Energy and Feasibility Optimal Global Scheduling Framework on big . LITTLE platforms

Motivated by ARM’s big.LITTLE, the cutting-edge heterogeneous multi-core architecture that supports migration between cores with different performance and energy efficiency, this paper targets global heterogeneous multi-core scheduling, and achieves the optimality in terms of energy consumption and feasibility. To this end, we address the problem of determining not only the system static configurations such as on-and-off status and voltage/frequency, and but also the time-varying schedule of each task. First, we abstract each task’s schedule as a rate of each task’s workload on each cluster (big and LITTLE) and formulate an optimization problem that achieves both energy and feasibility optimality. We then develop a time-efficient task workload allocation algorithm to assign the workload rate of each task and the system configurations. To generate task schedules from the algorithm, we establish feasibility-optimal scheduling rules for a two-type heterogeneous multi-core platform, which generalize the existing rules for a homogeneous one. Our simulation results demonstrate that our approach yields up to 37% less energy consumption without compromising feasibility than best-possible partitioned scheduling approaches obtained by solving an ILP optimization formulation.
Does the content really matter? A study comparing structure, process, and outcome of team rehabilitation for patients with inflammatory arthritis in two different clinical settings

Objectives: To provide a thorough description of team rehabilitation care and compare the structure, process, and outcomes in two specialized arthritis rehabilitation settings. Methods: Patients with inflammatory arthritis scheduled for inpatient rehabilitation in seven specialized rehabilitation centres and three rheumatology hospital departments in Norway were included consecutively in a prospective cohort study. Patients completed questionnaires at admission, at discharge, and at a 6-month follow-up, and kept a diary regarding structure and process variables during the rehabilitation stay. Results: Eighty patients in rehabilitation centres and 73 in hospital departments were included and 80% responded to the 6-month follow-up questionnaire. The two clinical settings differed significantly with regard to structure variables such as cost, referral of patients, length of stay, and number of health professionals involved, and most process variables reflecting treatment modalities. The most remarkable difference was in the amount of individual intervention compared with group intervention. Despite significant improvements in most outcomes at discharge, the scores deteriorated towards baseline level 6 months later. There was a trend towards more significant improvement during rehabilitation for patients at rehabilitation centres whereas patients at hospitals had more prolonged improvement. Conclusions: Team rehabilitation for inflammatory arthritis in two different clinical settings differed across most variables for structure and process, but few significant differences in outcome were found. Considering the substantial differences in cost, there is an urgent need for consensus concerning which patients should receive rehabilitation in which setting. Future research on the development and evaluation of methods for prolonging the beneficial effects of rehabilitation is needed.
Comparison of the proteins of two immunologically distinct intermediate-sized filaments by amino acid sequence analysis: desmin and vimentin.

Although all intermediate-size filaments (10-nm filaments) seem to show similar morphology and share a number of biochemical properties, different cell- and tissue-specific subclasses have been distinguished by immunological experiments and by differences in apparent molecular weights and isoelectric points of the major constituent proteins. In order to understand the degree of possible homology between these proteins, we have begun amino acid sequence analysis of the polypeptides. Here we characterize a large fragment of chicken gizzard and pig stomach desmin as well as the corresponding fragment from porcine eye lens vimentin. The fragments are situated at the carboxyl end and consist of 138-140 amino acid residues--i.e., some 28% of the corresponding polypeptide chains. The results show that the two immunologically distinct porcine proteins are different gene products. They show a related amino acid sequence but differ in 36% of the residues present in the carboxy-terminal region. Thus tissue specificity overrides species divergence. These results are discussed in the light of previous immunological experiments. They lend further support to the hypothesis that intermediate filaments belong to a multigene family, which is expressed in line with certain rules of differentiation during embryogenesis.
Health evaluation of free-ranging rockhopper penguins (Eudyptes chrysocomes) in Argentina.

As part of annual colony counts in Santa Cruz Province, Argentina, a health survey of rockhopper penguins (Eudyptes chrysocomes) was conducted in 1994. Forty-five birds were examined during handling procedures, and blood and fecal samples were collected for laboratory analysis. All birds appeared to be in good condition. No ecto- or endoparasites were found. Hematology, plasma chemistry, and plasma mineral levels were measured and correlated with the results of bacterial and viral serology. Antibodies against Chlamydia sp. , avian adenovirus, avian encephalomyelitis virus, infectious bronchitis virus, avian reovirus, and paramyxovirus-1, -2, and -3 were found. Mean plasma chemistry and mineral values differed between individuals testing positive and negative on serologic tests. There was no serologic evidence of exposure to avian influenza virus, duck viral enteritis, infectious bursal disease, infectious laryngotracheitis, Aspergillus sp. , or Salmonella pullorum. Trace amounts of endrin were found in the plasma of one bird, but all other chlorinated pesticide and polychlorinated biphenyl levels were below detectable limits.
Influence of hydrocolloidal silver nanoparticles on gastrointestinal microflora and morphology of enterocytes of quails

Abstract The objective of the present study was to examine the effects of hydrocolloidal silver nanoparticles (Ag-nano) on microbial profile of caecum and morphology of enterocytes in duodenum of Japanese quail, as a model animal for poultry. Quails (Coturnix coturnix japonica) (10 d old) were randomly divided into four groups (15 quails each) and located into four cages for 12 days. Quails were fed with granulated diets given ad libitum and had free access to drinking water. Ag-nano were added to drinking water at concentrations of 0, 5, 15 and 25 mg/kg. At the end of the experiment, the animals were killed and samples of duodenum and caeca microflora were collected. This initial investigation demonstrated that silver nanoparticles did not influence emphatically microflora of quail caecum; however, water containing 25 mg/kg of Ag-nano significantly increased the population of lactic acid bacteria. Furthermore, Ag-nano did not show any damaging properties on enterocytes of duodenal villi.
Choice-Based Demand Management and Vehicle Routing in E-Fulfillment

Attended home delivery services face the challenge of providing narrow delivery time slots to ensure customer satisfaction, while keeping the significant delivery costs under control. To that end, a firm can try to influence customers when they are booking their delivery time slot so as to steer them toward choosing slots that are expected to result in cost-effective schedules. We estimate a multinomial logit customer choice model from historic booking data and demonstrate that this can be calibrated well on a genuine e-grocer data set. We propose dynamic pricing policies based on this choice model to determine which and how much incentive (discount or charge) to offer for each time slot at the time a customer intends to make a booking. A crucial role in these dynamic pricing problems is played by the delivery cost, which is also estimated dynamically. We show in a simulation study based on real data that anticipating the likely future delivery cost of an additional order in a given location can lead to significantly increased profit as compared with current industry practice.
A class of physical modeling recurrent networks for analysis/synthesis of plucked string instruments

A new approach is proposed that closely synthesizes tones of plucked string instruments by using a class of physical modeling recurrent networks. The strategies employed consist of a fast training algorithm and a multistage training procedure that are able to obtain the synthesis parameters for a specific instrument automatically. The training vector can be recorded tones of most target plucked instruments with ordinary microphones. The proposed approach delivers encouraging results when it is applied to different types of plucked string instruments such as steel-string guitar, nylon-string guitar, harp, Chin, Yueh-chin, and Pipa. The synthesized tones sound very close to the originals produced by their acoustic counterparts. In addition, the paper presents an embedded technique that can produce special effects such as vibrato and portamento that are vital to the playing of plucked-string instruments. The computation required in the resynthesis processing is also reasonable.
Fibrin Sheath and its Relation to Subsequent Events after Tunneled Dialysis Catheter Exchange

The use of tunneled catheters (TDC) for chronic hemodialysis is frequent and often fails due to fibrin or thrombus and infection. We hypothesized that the presence of fibrin sheath in TDC increases the risk for subsequent catheter malfunction and infection. We did a retrospective review of TDC exchanges and de novo placements from January 2005 to September 2011. Demographic data, information about the catheter procedure, and radiological data were collected. Final outcome analysis included 168 procedure events. Three groups of catheter procedures were identified: catheter exchange without a fibrin sheath (CE), catheter exchange with a treated fibrin sheath (CEF), and de novo catheter placements (DCP). Fibrin sheath incidence was 47%. In the CEF group, there was no statistical difference in the incidence of subsequent infections or dysfunctions (7% and 60%, respectively), when compared with the CE group (9% and 43%, respectively), (p = 0.3). Mean time to subsequent dysfunction or infection was similar for CEF and CE (135 vs. 136 days, p‐value, 0.98). Fibrin sheaths are common and should be evaluated when performing TDC exchange. If the fibrin sheath is treated, there is no increased incidence in subsequent catheter dysfunction or infection compared with patients without a fibrin sheath.
A framework to guide the conservation of species hybrids based on ethical and ecological considerations

Species hybrids have long been undervalued in conservation and are often perceived as a threat to pure species. Recently, the conservation value of hybrids, especially those of natural origin, has gained recognition; however, hybrid conservation remains controversial. We reviewed hybrid management policies, including laws, regulations, and management protocols, from a variety of organizations, primarily in Canada and the United States. We found that many policies are based on limited ethical and ecological considerations and provide little opportunity for hybrid conservation. In most policies, hybrids are either unrepresented or considered a threat to conservation goals. This is problematic because our review of the hybrid conservation literature identified many ethical and ecological considerations relevant to determining the conservation value of a hybrid, all of which are management‐context specific. We also noted a lack of discussion of the ethical considerations regarding hybrid conservation. Based on these findings, we created a policy framework outlining situations in which hybrids could be eligible for conservation in Canada and the United States. The framework comprises a decision tree that helps users determine whether a hybrid should be eligible for conservation based on multiple ecological and ethical considerations. The framework may be applied to any hybrid and is flexible in that it accommodates context‐specific management by allowing different options if a hybrid is a threat to or could benefit conservation goals. The framework can inform policy makers and conservationists in decision‐making processes regarding hybrid conservation by providing a systematic set of decision criteria and guidance on additional criteria to be considered in cases of uncertainty, and it fills a policy gap that limits current hybrid management.
Design Scheme of New Tetragonal Heusler Compounds for Spin-Transfer Torque Applications and its Experimental Realization

Band Jahn-Teller type structural instabilities of cubic Mn(2)YZ Heusler compounds causing tetragonal distortions can be predicted by ab initio band-structure calculations. This allows for identification of new Heusler materials with tunable magnetic and structural properties that can satisfy the demands for spintronic applications, such as in spin-transfer torque-based devices.
Associations between craniomandibular disorders, sociodemographic factors and self-perceived general and oral health in an adult population

Abstract Objective. The aim of this study was to analyze the relationships between pain in the craniomandibular region and jaw dysfunction, respectively, to sociodemographic factors and self-perceived general and oral health in a middle-aged and elderly population in Västerbotten County, Sweden. Materials and methods. Six hundred individuals, 35-, 50-, 65- and 75 years old, from inland and 600 individuals from coastal areas were randomly selected in 2002. Of these, 987 individuals completed a questionnaire and 779 participated in a clinical examination. Thirty-five- and 50-year-olds together constituted a middle-aged group and the rest an elderly group. Results. Among the middle-aged, craniomandibular pain was associated with impaired general health status, signs of temporomandibular disorder (TMD) pain were associated with female gender and living alone, jaw dysfunction symptoms were associated with university degree and chewing with caution; and signs of TMD dysfunction were associated with female gender and living in the more densely populated coastal region. Among the elderly, craniomandibular pain was more common among those living in the inland region, craniomandibular pain and signs of TMD pain were associated with impaired general health status, jaw dysfunction symptoms were associated with higher education level and self-perceived impaired general health and oral health; and signs of TMD dysfunction were associated with female gender and living in the coastal region. Dental status was not associated with craniomandibular pain. Conclusions. Socioeconomic factors and impaired general state of health were related to signs and symptoms indicative of CMD. These factors may influence demand for treatment among the affected.
Donnéés stratigraphiques et paléogéographiques nouvelles sur le Cretacé supériur aux confins des chaines Ibérique et Catalane (Espagne)

El estudio del Cretaceo en la region de Horta de San Juan nos pemitio evidenciar, debajo de la serie senonense anteriormente reconocida, unas capas arcillo-arenosas y luego unas calcareo-dolomiticas con Prealveolinas, que representan respectivamente el Utrillas y el Cenomanense. Estas capas resultan transgresivas sobre un substrato jurasico, que se hace mas antiguo segun nos acercamos a la plataforma septentrional del Ebro. Se considera a los movimientos neocimerienses como responsables de la ausencia local del Cretacico inferior.
Disagreement after News: Gradual Information Diffusion or Differences of Opinion?

This paper considers the puzzle of increased trading volume around information releases through the lens of canonical models of disagreement. I use a unique data set of clicks on news by key finance professionals to simultaneously measure gradual information diffusion and differences of opinion. I find that neither channel subsumes the other and that the two are complementary in generating trading volume around news events. Their relative strengths depend on the characteristics of the underlying information: gradual information diffusion matters more for straightforward news, while differences of opinion play a larger role around textually ambiguous news. (JEL G12, G14, G41, D84) Received January 12, 2020; editorial decision: November 24, 2020 by Editor: Jeffrey Pontiff. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
The effects of statins on blood pressure: current knowledge and future perspectives

Statin therapy has gained interest in the field of hypertension due to the potential role of different statin agents in blood pressure (BP) lowering [1–3]. The potential mechanisms involved include the downregulation of the angiotensin II-type 1 receptor, the decrease of vasoconstrictor endothelin-1 levels, and the increase in the endothelial production of nitric oxide (NO), an effect that is correlated with the upregulation of endothelial NO synthase expression [4–6]. Furthermore, we have recently reported the effects of statin treatment on endothelial function, oxidative stress and inflammation in patients with hypertension and normal cholesterol levels [7]. Yet, despite the beneficial effects shown by statins in hypertensive animal models as well as in small clinical studies, the results from meta-analyses and large clinical trials have been controversial.
The Development of the Toronto Structured Interview for Alexithymia: Item Selection, Factor Structure, Reliability and Concurrent Validity

Background: Assessments of personality constructs increasingly use self-report and structured interview instruments, which allow for a multimethod measurement approach and decrease specific measurement method bias. The aim of this study was to develop a valid and reliable structured interview for assessing the alexithymia construct. Methods: Sixty interview questions were written initially, each with a set of scoring criteria and prompts and probes to elicit information assisting in the scoring of the respondents’ answers. Results: After pilot testing, the number of questions was reduced to 43, which were administered to 136 community participants and 97 psychiatric outpatients. A series of item and scale analyses further reduced the item pool to 24 items. Principal component analysis and confirmatory factor analysis of these 24 items revealed preliminary evidence of a hierarchical, four-factor structure, with four lower factors nested within two higher-order latent factors. This structural configuration resulted in the Toronto Structured Interview for Alexithymia (TSIA) with two domain scales and four facet scales. The TSIA and its six scales demonstrated acceptable levels of interrater, internal, and retest reliability. The TSIA and its scales correlated modestly but significantly with the 20-item Toronto Alexithymia Scale and its three factor scales, providing some support for the concurrent validity of this interview. Conclusion: The TSIA appears to be a promising structured interview for assessing alexithymia.