Miracle-dz/UniFAR-FTUs huggingface dataset:
Will Inequality Affect Growth? Evidence from USA and China since 1980

Income inequality may hinder economic growth is a widespread concern. The results from previous literature are mixed. Although both USA and China is an excellent case study by itself, it is even interesting to compare them given they are the two largest economies in the world, and yet completely different from each other. We employ annual data from 1980 to 2012 and apply cointegration to study the effects of income inequality on real GDP per capita and real GDP of both USA and China. We also include the exchange rate into the model to examine possible effects of depreciation on growth. The main findings are: first, depreciation does not affect the growth of USA. Second, depreciation promotes growth of China in the short-run, but may hurt its growth in the long-run. Third, income inequality will hurt growth of USA in the short-run, while it encourages its growth in the long-run. Finally, income inequality may promote growth of China in both short-run and long-run.
Cesarean delivery fluid management.

PURPOSE OF REVIEW To guide the optimal fluid management during cesarean delivery. The article focuses on fluid management to prevent hypotension during cesarean delivery performed under spinal anesthesia and excludes obstetric hemorrhage. RECENT FINDINGS The literature underlines that crystalloid preloading is ineffective or poorly effective to prevent spinal hypotension during cesarean delivery. Crystalloid coloading is better but the effectiveness reported is variable and may depend on the volume used and the speed of administration at onset of sympathetic blockade. Hydroxyethyl starch (HES) preloading is more consistently effective in reducing the incidence and severity of hypotension. HES coloading appears as effective as HES preloading. Because none of these fluid-loading methods is completely effective at preventing hypotension, some sort of prophylactic vasopressor regimen should always be added. Routine fluid loading is no longer advocated prior to spinal anesthesia for cesarean delivery in preeclampsia and should be used with caution in women with multiple gestations. SUMMARY Current evidence suggests that combining a prophylactic vasopressor regimen with HES preloading, HES coloading or crystalloid coloading is the best method of preventing maternal hypotension after the initiation of spinal anesthesia. Crystalloid preloading is clinically ineffective and thus should no longer be used.
Stock reaction to market-wide information: Working paper series--08-14

An anomaly within the behavioral literature is that as yet there is no evidence suggesting that stocks mis-react to common information as they do to firm-specific information. We demonstrate the limitations of the previous research and revisit the issue of stock reaction to common information in this manuscript. We find a statistically and economically significant reaction pattern to common information as the behavioral models suggest we should. This finding thus complements the findings of stock mis-reaction to firm-specific information, and should benefit researchers attempting to understand investor behavior. Furthermore, we find that the size factor may not only proxy future economic growth as suggested by Vassalou (2003), but also the delayed reaction to the news related to future economic growth.
The Impact of Language Skills on Immigrants’ Labor Market Integration: A Brief Revision With a New Approach

I examine the impact of language skills on immigrants’ labor market performance by applying a new approach, which allows to estimate wage benefits attributed to initial language skills at arrival. By exploiting unique data, I isolate the endogenous part of current German skills and instrument current command by German proficiency measured retrospectively at the point in time of migration. This approach tackles the problem that labor market effects from current language skills are at risk to reflect merely the sum of a successful residence in Germany and only display growth effects. I find that a good command of German increases labor market income by 47.0% for males, while no significant language effects are detected for females. Further analyses illustrate that differences in language effects by gender can be attributed to selection into different occupations and part-time employments and that language operates complementary and enables cross-border transferability of human capital.
Timing Games with Irrational Types: Leverage-Driven Bubbles and Crash-Contingent Claims

Abstract This study investigates strategic aspect of leverage-driven bubbles from the viewpoint of game theory and behavioral finance. Even if a company is unproductive, its stock price grows up according to an exogenous reinforcement pattern. During the bubble, this company raises huge funds by issuing new shares. Multiple arbitrageurs strategically decide whether to ride the bubble by continuing to purchase shares through leveraged finance. We demonstrate two models that are distinguished by whether crash-contingent claim, i. e. contractual agreement such that the purchaser of this claim receives a promised monetary amount if and only if the bubble crashes, is available. We show that the availability of this claim deters the bubble; without crash-contingent claim, the bubble emerges and persists long even if the degree of reinforcement is insufficient. Without crash-contingent claim, high leverage ratio fosters the bubble, while with crash-contingent claim, it rather deters the bubble. We formulate these models as specifications of timing game with irrational types; each player selects a time in a fixed time interval, and the player who selects the earliest time wins the game. We assume that each player is irrational with a small but positive probability. We then prove that there exists the unique Nash equilibrium; according to it, every player never selects the initial time. By regarding arbitrageurs as players, we give careful conceptualizations that are necessary to interpret timing games as models of leverage-driven bubbles.
Olfactory‐enriched transcripts are cell‐specific markers in the lobster olfactory organ

Genes expressed specifically in a tissue are often involved in the defining functions of that tissue. We used representational difference analysis of cDNA to amplify 20 cDNA fragments representing transcripts that were more abundant in the lobster olfactory organ than in brain, eye/eyestalk, dactyl, pereiopod, or second antenna. We then independently confirmed that the transcripts represented by these clones were enriched in the olfactory organ. The 20 cDNA fragments represent between 6 and 15 different genes. Six of the cDNAs contained sequences highly similar to known gene families. We performed in situ hybridization with these six and found that all were expressed in subsets of cells associated with the aesthetasc sensilla in the olfactory organ. Clones OET‐07, an ionotropic receptor, and OET‐10, an α tubulin, were specific to the olfactory receptor neurons. OET‐02, a monooxygenase, was expressed only in the outer auxiliary cells. OET‐03, a serine protease, was specific to the collar cells. OET‐11, an α2 macroglobulin, was expressed by the receptor neurons and the collar cells. OET‐17, a calcyphosine, was expressed in the receptor neurons, inner auxiliary cells, and collar cells. The identities and expression patterns of these six transcripts predict involvement in both known and novel properties of the lobster olfactory organ. J. Comp. Neurol. 455:125–138, 2003. © 2002 Wiley‐Liss, Inc.
Isolated Port-Site Metastases After Minimally Invasive Hysterectomy for Endometrial Cancer: Outcomes of Patients Treated With Radiotherapy

Objective The management and prognosis of isolated port-site metastases after laparoscopic surgery for endometrial cancer is poorly understood and rarely described in the literature. We report a series of cases treated with radiotherapy to better characterize outcomes in these patients. Methods We retrospectively reviewed medical records of patients with endometrial cancer who developed isolated port-site metastases and were treated with radiation therapy at MD Anderson Cancer Center from 1996 to 2013. Seven patients met these criteria for whom treatment and outcome data were collected. Results The median interval from initial surgery to port-site recurrence was 15 months. Recurrent tumor size varied from 0.5 to 9 cm as measured on axial imaging. Six of the 7 patients underwent surgical resection of the recurrence. All received radiotherapy to a dose of 45 to 66 Gy. At a median follow-up of 2 years from the time of the port-site recurrence, the rate of disease-free survival at 1 and 2 years after the recurrence was 100% and 44%, respectively. The rate of local control and overall survival at 2 years was 100%. Conclusions Isolated port-site metastases in the setting of endometrial cancer are associated with high rates of local control when treated with multimodality therapy including radiotherapy. Long-term disease-free outcomes in some patients suggest the potential for cure and justify aggressive local therapy. The optimal integration of surgery, chemotherapy, and radiation is unknown.
Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling

Progression of hepatocellular carcinoma (HCC) is a stepwise process that proceeds from pre‐neoplastic lesions—including low‐grade dysplastic nodules (LGDNs) and high‐grade dysplastic nodules (HGDNs)—to advanced HCC. The molecular changes associated with this progression are unclear, however, and the morphological cues thought to distinguish pre‐neoplastic lesions from well‐differentiated HCC are not universally accepted. To understand the multistep process of hepato‐carcinogenesis at the molecular level, we used oligo‐nucleotide microarrays to investigate the transcription profiles of 50 hepatocellular nodular lesions ranging from LGDNs to primary HCC (Edmondson grades 1‐3). We demonstrated that gene expression profiles can discriminate not only between dysplastic nodules and overt carcinoma but also between different histological grades of HCC via unsupervised hierarchical clustering with 10,376 genes. We identified 3,084 grade‐associated genes, correlated with tumor progression, using one‐way ANOVA and a one‐versus‐all unpooled t test. Functional assignment of these genes revealed discrete expression clusters representing grade‐dependent biological properties of HCC. Using both diagonal linear discriminant analysis and support vector machines, we identified 240 genes that could accurately classify tumors according to histological grade, especially when attempting to discriminate LGDNs, HGDNs, and grade 1 HCC. In conclusion, a clear molecular demarcation between dysplastic nodules and overt HCC exists. The progression from grade 1 through grade 3 HCC is associated with changes in gene expression consistent with plausible functional consequences. Supplementary material for this article can be found on the HEPATOLOGY website (http://www.interscience.wiley.com/jpages/0270‐9139/suppmat/index.html). (HEPATOLOGY 2005;42:809–818.)
Explaining the 25-year decline of serum cholesterol by dietary changes and use of lipid-lowering medication in Finland

Abstract Objective To assess to what extent the observed dietary changes and increased use of lipid-lowering medication can explain the almost 20 % decline in serum cholesterol (referring to serum total cholesterol) level observed from 1982 to 2007 in Finland. Design Predicted changes of serum cholesterol were calculated by the Keys’ equation assuming the effect of trans fatty acids to be similar to SFA and using the dietary intake data of the national dietary surveys between 1982 and 2007. The effect of medication was estimated based on the information on use of lipid-lowering medication among survey participants. The predicted serum cholesterol levels were compared with observed changes in analysed serum cholesterol levels. Setting Four cross-sectional population surveys, in 1982, 1992, 2002 and 2007, in the provinces of North Karelia, Northern Savo and Southwestern Finland. Subjects A total of 2325 men and 2638 women aged 26–64 years selected randomly from the national population register for the four surveys. Results Changes in dietary fat quality and cholesterol intake explain 0·70 mmol/l (65 %) of the decrease in men and 0·65 mmol/l (60 %) of the decrease in women in all subjects. Decline in dietary SFA intake is the main explanatory factor (47 % in men and 41 % in women) for the changes. The impact of lipid-lowering medication on observed cholesterol levels was found to be 16 % among men and 7 % among women. Conclusions The decrease in serum cholesterol levels in Finland can be explained mainly by dietary changes, especially changes in fat quality. The effect of lipid-lowering medication is less significant.
Tissue-specific expression of inducible and constitutive Hsp70 isoforms in the western painted turtle

SUMMARY Expression of Hsp73 and Hsp72 in four tissues of the naturally anoxia-tolerant western painted turtle (Chrysemys picta) was investigated in response to a 24 h forced dive and following 1 h recovery. Of the tissues examined, brain and liver displayed approximately threefold and sevenfold higher basal Hsp73 expression than heart and skeletal muscle. Basal Hsp72 expression was relatively low in all tissues examined. After the 24 h forced dive and 1 h recovery, Hsp73 expression did not differ significantly from basal expression with the exception of liver, where expression decreased significantly after 1 h recovery. Hsp72 expression was unchanged in liver following a 24 h dive; however, it increased twofold in brain and threefold in heart and skeletal muscle. Dive-induced Hsp72 expression was found to correlate inversely with basal Hsp73 expression. Following 1 h recovery, Hsp72 expression was significantly elevated in all tissues above levels in dived animals. These data indicate a tissue-specific pattern of Hsp73 and Hsp72 expression in the western painted turtle during both unstressed and stressed conditions.
Aging and Immortality: Quasi-Programmed Senescence and Its Pharmacologic Inhibition

While ruling out programmed aging, evolutionary theory predicts a quasi-program for aging, a continuation of the developmental program that is not turned off, is constantly on, becoming hyper-functional and damaging, causing diseases of aging. Could it be switched off pharmacologically? This would require identification of a molecular target involved in cell senescence, organism aging and diseases of aging. Notably, cell senescence is associated with activation of the TOR (target of rapamycin) nutrient- and mitogen-sensing pathway, which promotes cell growth, even though cell cycle is blocked. Is TOR involved in organism aging? In fact, in yeast (where the cell is the organism), caloric restriction, rapamycin and mutations that inhibit TOR all slow down aging. In animals from worms to mammals caloric restrictions, life-extending agents, and numerous mutations that increase longevity all converge on the TOR pathway. And, in humans, cell hypertrophy, hyper-function and hyperplasia, typically associated with activation of TOR, contribute to diseases of aging. Theoretical and clinical considerations suggest that rapamycin may be effective against atherosclerosis, hypertension and hyper-coagulation (thus, preventing myocardial infarction and stroke), osteoporosis, cancer, autoimmune diseases and arthritis, obesity, diabetes, macula-degeneration, Alzheimer’s and Parkinson’s diseases. Finally, I discuss that extended life span will reveal new causes for aging (e.g., ROS, ‘wear and tear’, Hayflick limit, stem cell exhaustion) that play a limited role now, when quasi-programmed senescence kills us first.
Evaluation of an infant simulator intervention for teen pregnancy prevention.

OBJECTIVE To evaluate the effectiveness of simulation as a strategy to influence teens' perceptions of pregnancy and parenting. DESIGN This pilot study was a preexperimental, one group pre/posttest design. SETTING The school-based wellness center of a high school was the setting for the weekly sessions and the pre/posttest administration. PARTICIPANTS Sample members participated in 6 weekly Baby Think it Over (BTIO) classes and an infant simulator experience. The final sample included 79 teens age 14 to 18 years who attended one of eight BTIO sessions. METHODS We used the Thoughts on Teen Parenting Survey (TTPS) to assess the perceptions of teens with regard to the costs and rewards associated with teen parenting. The TTPS yields a composite score of the teen attitudes toward the teen parenting experience and eight subscale scores that assess different areas of teen life. RESULTS No significant differences were found in the mean pre/posttest scores or in correlations of the demographic data and mean scores. Two significant differences in pre/posttest subscale scores were in the areas of friends and personal characteristics. CONCLUSIONS The results of this study suggest that the effectiveness of using infant simulators to influence the perceptions of teens about the reality of teen parenting is minimal.
Inferior petrosal sinus sampling in the differential diagnosis of Cushing's syndrome: results of an Italian multicenter study.

OBJECTIVE To evaluate the diagnostic accuracy of inferior petrosal sinus sampling (IPSS) in the differential diagnosis of ACTH-dependent Cushing's syndrome as compared with pituitary imaging techniques. DESIGN AND METHODS We retrospectively studied the diagnostic accuracy of basal and post corticotropin-releasing hormone (CRH) IPSS, magnetic resonance imaging and computed tomography in distinguishing pituitary from ectopic ACTH secretion in 97 Cushing's syndrome patients: 74 with Cushing's disease (CD) and 10 with ectopic ACTH secretion (EAS). Thirteen patients were excluded because of unconfirmed diagnosis. The difference between IPSS and pituitary imaging techniques in the correctly localized pituitary adenoma in the patients with CD was also investigated. RESULTS The basal ACTH inferior petrosal sinus:periphery (IPS:P) ratio was > or = 2 in 63/74 patients with CD (85%), and in 1/10 EAS patients (10%); after stimulation with CRH, the ratio was > or = 3 in 60/68 patients with CD (88%) and < 3 in all patients with EAS. The basal and post-CRH ACTH IPS:P ratios had a diagnostic accuracy of 86% and 90% respectively. The diagnostic accuracy of IPSS with both ratios was significantly higher than magnetic resonance imaging (50%) and computed tomography (40%). The IPS:P ratio suggested by receiver-operator characteristic (ROC) analysis that better distinguished CD from EAS was 2.10 for the basal and 2.15 for the post-CRH ratios. Using these cut-offs, the specificity of basal ratio and the sensitivity of the post-CRH test rose to 100% and 93% respectively. Diagnostic accuracy remained substantially unchanged for the basal ratio (87% vs 86%), while it rose from 90% to 94% for the post-CRH ratio. The sensitivity of IPSS was significantly higher than that of magnetic resonance and computerized tomography. IPSS was less reliable in identifying the adenoma site found at surgery than magnetic resonance imaging or computed tomography (65% vs 75% and 79% respectively). CONCLUSION In conclusion, IPSS improved the diagnostic performance of imaging techniques. It can help in excluding transsphenoidal surgery in EAS patients. More striking results were obtained when a > or = 2.1:1 basal ratio or a > or = 2.15:1 post-CRH ratio were considered as criteria to distinguish between patients with CD and EAS. To establish correctly the location of the pituitary adenoma, IPSS is less reliable than imaging techniques.
Matrix metalloproteinases and aggrecanases cleave aggrecan in different zones of normal cartilage but colocalize in the development of osteoarthritic lesions in STR/ort mice.

OBJECTIVE To map aggrecan cleavage by matrix metalloproteinases (MMPs) and aggrecanases in normal murine tibial articular cartilage (CBA strain) and in the development of spontaneous osteoarthritis (OA) in the STR/ort mouse and to assess the influence of sex hormone status on these conditions in gonadectomized STR/ort mice. METHODS The distributions of neoepitopes of aggrecan generated by MMP (VDIPEN) and aggrecanase (NITEGE) cleavage were investigated by immunohistochemistry. RESULTS VDIPEN neoepitope was detected mainly in the pericellular matrix of deep-zone chondrocytes in normal tibial cartilage from STR/ort and CBA mice. In early OA, VDIPEN immunostaining also localized to the pericellular matrix of chondrocytes at the site of the lesion. With increasing severity of OA lesions, VDIPEN immunostaining was also detected in the interterritorial matrix, close to the site of the lesion. In contrast, NITEGE mapped most strongly to the pericellular matrix of upper-zone chondrocytes in normal tibial cartilage. As with VDIPEN, NITEGE was strongly expressed in the pericellular matrix at the site of early OA lesions. With advancing OA, NITEGE colocalized with VDIPEN in both the pericellular and interterritorial matrices of chondrocytes adjacent to OA lesions and in those of the deep zones. Hormone status did not appear to influence the development of OA or the distribution of aggrecan neoepitopes in STR/ort mice. CONCLUSION MMP- and aggrecanase-generated neoepitopes map predominantly to different regions in normal murine tibial cartilage. However, both groups of enzymes generate increased amounts of neoepitopes in pericellular and interterritorial matrix adjacent to histopathologic lesions of OA. Aggrecan degradation and the development of OA appear to be independent of sex hormone status in this model.
Symmetry and asymmetry in mandelate racemase catalysis.

Kinetic properties of mandelate racemase catalysis (Vmax, Km, deuterium isotope effects, and pH profiles) were all measured in both directions by the circular dichroic assay of Sharp et al. [Sharp, T. R. , Hegeman, G. D. , & Kenyon, G. L. (1979) Anal. Biochem. 94, 329]. These results, along with those of studying interactions of mandelate racemase with resolved, enantiomeric competitive inhibitors [(R)- and (S)-alpha-phenylglycerates], indicate a high degree of symmetry in both binding and catalysis. Racemization of either enantiomer of mandelate in D2O did not show an overshoot region of molecular ellipticity in circular dichroic measurements upon approach to equilibrium. Both the absence of such an overshoot region and the high degree of kinetic symmetry are consistent with a one-base acceptor mechanism for mandelate racemase. On the other hand, results of irreversible inhibition with partially resolved, enantiomeric affinity labels [(R)- and (S)-alpha-phenylglycidates] reveal a "functional asymmetry" at the active site. Mechanistic proposals, consistent with these results, are presented.
Iatrogenic keratectasia after laser in situ keratomileusis.

BACKGROUND Lamellar refractive surgery reduces the biomechanical strength of the cornea which may lead to mechanical instability and keratectasia. METHODS Three eyes had laser in situ keratomileusis (LASIK) for myopia from -10.00 to -13.50 D. The procedures were performed with two different wide-field excimer lasers and two different microkeratomes. The patients were followed up to 1 year after surgery. RESULTS Central steep areas developed between 1 and 8 months after surgery. In contrast to conventional central steep islands, these showed rapid progression and were interpreted as keratectasia. CONCLUSION Iatrogenic keratectasia represents a complication after LASIK that may limit the range of myopia correction. Based on biomechanical considerations we recommend a residual corneal thickness of the stromal bed of at least 250 microm.