Miracle-dz/UniFAR-FTUs huggingface dataset:
Anabolic implant effects on steer performance, carcass traits, subprimal yields, and longissimus muscle properties.

Crossbred steers (n = 140; 353 kg) were implanted as follows: (C) control, no implant; (S) Synovex-S (20 mg estradiol benzoate + 200 mg progesterone); (R) Revalor (20 mg estradiol + 140 mg trenbolone acetate [TBA]; international dosage); (ST) S + finaplix-S (140 mg TBA); (STT) S + finaplix-S with finaplix-S reimplanted on d 58. Steers were harvested after 119 to 126 d on feed. Left sides of 40 carcasses were fabricated into boneless subprimals for two s.c. fat levels: 2.5 and . 64 cm. Steers administered an estrogen (estradiol benzoate or estradiol) plus TBA gained more rapidly (P < .05) than C or S steers. Feed efficiency was improved (P < .05) with an estrogen plus TBA. No differences (P > .05) were noted among treatments for carcass s.c. fat thickness, percentage internal fat, or lean color. Carcasses from steers receiving TBA had larger (P < .05) longissimus areas and tended to have lower (P < .10) marbling scores and yield grades than C or S steers. Steers implanted with R had a lower (P < .05) percentage of U. S. Choice carcasses (51.8%) than C, S, and ST steers (82 to 86%). Shear force values for implanted steers tended to be higher (P < .10) than for controls. Implants increased (P < .05) subprimal and total side lean yields (.64 cm) compared to controls; the largest increases of 2.3 and 2.8%, respectively, occurred in steers receiving TBA plus an estrogen. Estrogen plus TBA exhibited favorable effects on gain, efficiency, and composition; however, the single estradiol plus TBA implant (R) decreased quality grade.
Heaping on Dividends: The Role of Dividend Size and Information Uncertainty

Abstract The authors examine whether a cognitive bias influences dividend policy. They find that managers use a heaping heuristic when choosing the amount of their firm’s dividend. Heaping is a human error or bias to round numbers even though precise values are desired. This bias leads to dividend distributions clustered at specific amounts. Dividend size and the level of information uncertainty faced by management help explain the likelihood of heaping. The authors also observe that heaped dividends are “sticky” and altered less frequently, and when there is a dividend change, heaped dividends are more often switched to another heaped amount.
Patients Homozygous for the T435N Mutation of Succinyl-CoA:3-Ketoacid CoA Transferase (SCOT) Do Not Show Permanent Ketosis

Succinyl-CoA:3-ketoacid CoA transferase (SCOT; locus symbol OXCT; E.C. 2.8.3.5) is the main determinant of the ketolytic capacity of tissues. Hereditary SCOT deficiency causes episodic ketoacidosis. Permanent ketosis has been regarded as a pathognomonic feature of SCOT deficiency. There are three SCOT-deficient patients from a small region in Japan and they have not manifested permanent ketosis, even though their ketoacidotic crises were as severe as those of other SCOT-deficient patients. All three were homozygous for the T435N mutation. Transient expression analysis of wild-type and mutant cDNA showed that the T435N mutant retained significant residual SCOT activities (20% for that of the wild-type at 39.5°C, 25% at 37°C, and 50% at 30°C). The difference of residual SCOT activities at these temperatures in expression analyses was due to differences in the level of the mutant protein. SCOT activity of the T435N protein was more vulnerable than the wild-type to heat treatment at 42°C and 55°C. These temperature-sensitive characteristics of the mutant protein may explain, in part, why the patients developed ketoacidotic crises during febrile illness. In SCOT-deficient patients retaining some residual activity, permanent ketosis may be absent.
Identification of an immunodominant sequential epitope in glycoprotein G of herpes simplex virus type 2 that is useful for serotype‐specific diagnosis

A series of 67 oligopeptides that spanned the open reading frame of herpes simplex virus type 2 (HSV‐2) glycoprotein G (gG2) were synthesized and tested for reactivity with 173 serum specimens collected from 117 individuals. The oligopeptides were made as multiple antigenic peptides consisting of four copies of a unique sequence attached to a branched lysine core and separated from the core by four glycine residues. The sera included HSV antibody‐negative samples as well as sera from individuals from whom HSV had been isolated. Isolated viruses were typed by indirect fluorescence using a panel of type‐specific monoclonal antibodies. One peptide, corresponding to residues 561 to 578 of gG2, did not react with any sera lacking HSV‐specific antibodies or with sera from HSV‐1‐infected individuals, but did react with sera from HSV‐2‐infected individuals. For sera taken seven or more days after initialclinical lesions, the detection rate of the peptide was 92% (47/51), comparable with the 98% (50/51) of truncated glycoprotein D, a sensitive type‐common reagent. We conclude that this peptide, of structure (PEEFEGAGDGEPPEDDDSG4)K3A, is an immunodominant type‐specific epitope for human antibodies and should be useful for type‐specific serodiagnosis of HSV‐2. Surprisingly, the epitope lies within one of the most conserved regions of gG1 and gG2. The test can distinguish an initial HSV‐2 infection in the presence of a preexisting HSV‐1 infection. J. Med. Virol. 56:79–84, 1998. © 1998 Wiley‐Liss, Inc.
Purification and partial characterization of a membrane-associated lipoxygenase in tomato fruit.

Membrane-associated lipoxygenase from green tomato (Lycopersicon esculentum L. cv Caruso) fruit has been purified 49-fold to a specific activity of 8.3 mumol.min(-1). mg(-1) of protein by solubilization of microsomal membranes with Triton X-100, followed by anion- exchange and size-exclusion chromatography. The apparent molecular mass of the enzyme was estimated to be 97 and 102 kD by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and size-exclusion chromatography, respectively. The purified membrane lipoxygenase preparation consisted of a single major band following sodium dodecyl sulfate-polyacrylamide gel electrophoresis, which cross-reacts with immunoserum raised against soluble soybean lipoxygenase 1. It has a pH optimum of 6.5, an apparent K(m) of 6.2 mum, and V(max) of 103. mumol.min(-1). mg(-1) of protein with linoleic acid as substrate. Corresponding values for the partially purified soluble lipoxygenase from tomato are 3.8 mum and 1.3 mumol.min(-1). mg(-1) of protein, respectively. Thus, the membrane-associated enzyme is kinetically distinguishable from its soluble counterpart. Sucrose density gradient fractionation of the isolated membranes indicated that the membrane-associated lipoxygenase sediments with thylakoids. A lipoxygenase band with a corresponding apparent mol wt of 97,000 was identified immunologically in sodium dodecyl sulfate-polyacrylamide gel electrophoresis-resolved proteins of purified thylakoids prepared from intact chloroplasts isolated from tomato leaves and fruit.
Use of cardiac catheterization for non-ST-segment elevation acute coronary syndromes according to initial risk: reasons why physicians choose not to refer their patients.

BACKGROUND Despite the recommendation for an early invasive strategy in the treatment of patients who present with non-ST-segment elevation (NSTE) acute coronary syndromes (ACS), referral for cardiac catheterization is suboptimal; the reasons why some patients are not referred remain unclear. METHODS Patients were recruited into the prospective, observational Canadian ACS Registry II between October 1, 2002, and December 31, 2003; 2136 patients with NSTE ACS identified through the registry were divided into tertiles according to the Thrombolysis in Myocardial Infarction risk score and the rates of catheterization compared. In addition, the most responsible physicians were asked to indicate the main reason they did not refer their patients for catheterization. RESULTS The rate of referral for catheterization was 64.7%. Patients who underwent catheterization had lower in-hospital (0.8% vs 3.7%; P < .001) and 1-year mortality rates (4.0% vs 10.9%; P < .001) compared with those who did not. Higher-risk patients were referred at a similar rate as low-risk patients (62.5% vs 66.9%; P = .25). Among the reasons provided by the most responsible physician as to why patients were not referred for catheterization, 68.4% of patients were thought to be "not at high enough risk"; however, 59.1% of these patients were found to be at intermediate to high risk according to their baseline Thrombolysis in Myocardial Infarction risk score. CONCLUSIONS Cardiac catheterization is not used optimally in patients who present with NSTE ACS. Despite better in-hospital and 1-year outcomes in those patients who are referred for catheterization, many higher-risk patients are not being referred because of the perception that they are not at high enough risk. A significant opportunity remains to improve on accurate risk stratification and adherence to an early invasive strategy for higher-risk patients.
Abortive Ectromelia Virus Infection in Peritoneal Macrophages Activated by Corynebacterium parvum

We have previously demonstrated that peritoneal macrophages (Mϕs) from C3H mice were resistant to in vitro infection by ectromelia virus, following activation by intraperitoneal injection of the immunomodulator Corynebacterium parvum. In contrast, resident and mineral oil‐elicited Mϕs were fully susceptible to virus infection. This report analyzes the infectious cycle of ectromelia virus in C parvum‐activated and mineral oil‐elicited Mϕs and demonstrates that an abortive infection occurred in the activated Mϕs that blocked the infectious cycle prior to the release of DNA from the infecting virions. The kinetics of adsorption of radiolabeled virus were similar in both susceptible and resistant Mϕ cultures; however, viral‐induced incorporation of uridine and thymidine occurred only in the mineral oil‐elicited and not the C parvum‐activated Mϕs. In addition, the late protein hemagglutinin was only detected in infected cultures of susceptible mineral oil‐elicited Mϕs. An electron micrographic analysis of the infectious cycle indicated that the adsorption of virus to the plasma membrane, uptake into lysosomes, and the primary undercoating and release of viral cores into the Mϕ cytoplasm were identical in both Mϕ types. In contrast, secondary uncoating (release of genomic DNA from the viral cores into the cytoplasm) was never detected in infected C parvum Mϕs. These data are consistent with our previous findings and with the hypothesis that activation of Mϕs by C parvum induces an interferon‐mediated resistance to ectromelia virus infection.
Fraud prevention in Malaysian small and medium enterprises (SMEs)

Purpose In Malaysia, as in most of the developing countries, small businesses play pivotal roles in the economy. Yet, despite the contribution of small businesses, previous researchers have overlooked the fraud issues that are threating the sustainability of those businesses, and instead focus mainly on large and public listed companies. Therefore, this study is conducted to identify how small businesses can prevent fraudulent activities Design/methodology/approach This study used self-administer questioners and distributed 126 questionnaire to general managers, financial managers, and supervisors at Malaysian’s SMEs. Multiple regression was used to test the theoretical model. Findings The output of multiple regressions showed that culture of honesty and high integrity, antifraud processes and controls, and appropriate oversight functions has a positive and significant effective on fraud prevention mechanisms. Practical implications Overall, this study suggests effective fraud prevention measures to mitig.
Structural features of ribonucleotide reductase

Herpes simplex virus type 1 (HSV‐1) encodes a ribonucleotide reductase which comprises two polypeptides with sizes of 136,000 (RR1) and 38,000 mol. wt. (RR2). We have determined the entire DNA sequence specifying HSV‐1 RR1 and have identified two adjacent open reading frames in varicella‐zoster virus (VZV) which have homology to HSV RR1 and RR2; the predicted sizes for the VZV RR1 and RR2 polypeptides are 87,000 and 35,000 mol. wt. respectively. Amino acid comparisons with RR1 and RR2 polypeptides from other organisms indicate that HSV‐1 RR1 contains a unique N‐terminal domain which is absent from other RR1 polypeptides apart from HSV‐2 RR1. These N‐terminal amino acid sequences are poorly conserved between HSV‐1 and HSV‐2 in contrast to the remainder of the protein which shows greater than 90% homology. Polypeptide structural predictions suggest that the HSV‐1 N‐terminal domain may be separated into two regions, namely, a β‐sheet structure followed by a nonstructured area. Across the remainder of RR1 and RR2, comparisons also reveal blocks of amino acids conserved between the different ribonucleotide reductases, and these may be important for enzyme activity. From predictions on the structure of these conserved blocks, we have proposed that the location of a substrate binding site within RR1 is centered on three conserved glycine residues in a region which is predicted to adopt a β‐sheet/turn/α‐helical structure;this approximates to the structure for ADP nucleotide binding folds. Finally, we propose that the promoters for the HSV and Eptein‐Barr virus (EBV) RR2 transcripts have evolved by separate evolutionary routes.
Long-term neurodevelopmental outcomes in school-aged children after neonatal arterial switch operation.

OBJECTIVE Neurodevelopmental status of children between 8 and 14 years of age after neonatal arterial switch operation for transposition of the great arteries has not previously been systematically evaluated. METHODS Within a longitudinal study, 60 unselected children operated on as neonates with combined deep hypothermic circulatory arrest and low-flow cardiopulmonary bypass were reevaluated at the age of 7.9 to 14.3 years (mean +/- SD 10.5 +/- 1.6 years). Clinical neurologic status and standardized tests to assess gross motor function, intelligence, acquired abilities, language, and speech were carried out, and the results were related to preoperative, perioperative, and postoperative status, to management, and to neurodevelopmental status at a mean age of 5.4 years. RESULTS Neurologic and speech impairments were evidently more frequent (27% and 40%, respectively) than in the general population. Intelligence and socioeconomic status were not different (P =.29 and P =.11), whereas motor function, acquired abilities, and language were reduced (P < or =.04 for each). Overall rate of developmental impairment in one or more domains was 55%, compared with 26% at age 5.4 years. Multivariable analysis showed that severe preoperative acidosis and hypoxia predicted reduced motor function (mean deficit 52.7 points, P <.001), whereas longer bypass duration predicted both neurologic (odds ratio per 10 minutes of bypass duration 1.8, P =.04) and speech (odds ratio per 10 minutes of bypass duration 1.9, P =.02) dysfunction, and perioperative and postoperative cardiocirculatory insufficiency predicted neurologic (odds ratio 6.5, P =.04) and motor (mean deficit 6.8 points, P =.03) dysfunction. CONCLUSIONS The neonatal arterial switch operation with combined circulatory arrest and low-flow bypass is associated increasingly with age, with reduced neurodevelopmental outcome but not with cognitive dysfunction. In our experience, the risk of long-term neurodevelopmental impairment after neonatal corrective cardiac surgery is related to deleterious effects of the global perioperative management and to special adverse effects of prolonged bypass duration. Severe preoperative acidosis and hypoxia and postoperative hemodynamic instability must be considered as important additional risk factors.
Severe acute liver injury associated with lumiracoxib

Backgound and Aim: Significant elevations in liver transaminases were noted in some patients during pre‐marketing clinical trials with lumiracoxib, a selective COX‐2 inhibitor. It was withdrawn from the Australian market in August 2007, because of an association with severe liver injury. We describe in detail three cases of severe liver injury in patients taking lumiracoxib
Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.

OBJECT Chordoma is a malignant bone neoplasm hypothesized to arise from notochordal remnants along the length of the neuraxis. Recent genomic investigation of chordomas has identified T (Brachyury) gene duplication as a major susceptibility mutation in familial chordomas. Brachyury plays a vital role during embryonic development of the notochord and has recently been shown to regulate epithelial-to-mesenchymal transition in epithelial-derived cancers. However, current understanding of the role of this transcription factor in chordoma is limited due to the lack of availability of a fully characterized chordoma cell line expressing Brachyury. Thus, the objective of this study was to establish the first fully characterized primary chordoma cell line expressing gain of the T gene locus that readily recapitulates the original parental tumor phenotype in vitro and in vivo. METHODS Using an intraoperatively obtained tumor sample from a 61-year-old woman with primary sacral chordoma, a chordoma cell line (JHC7, or Johns Hopkins Chordoma Line 7) was established. Molecular characterization of the primary tumor and cell line was conducted using standard immunostaining and Western blotting. Chromosomal aberrations and genomic amplification of the T gene in this cell line were determined. Using this cell line, a xenograft model was established and the histopathological analysis of the tumor was performed. Silencing of Brachyury and changes in gene expression were assessed. RESULTS The authors report, for the first time, the successful establishment of a chordoma cell line (JHC7) from a patient with pathologically confirmed sacral chordoma. This cell line readily forms tumors in immunodeficient mice that recapitulate the parental tumor phenotype with conserved histological features consistent with the parental tumor. Furthermore, it is demonstrated for the first time that silencing of Brachyury using short hairpin RNA renders the morphology of chordoma cells to a more differentiated-like state and leads to complete growth arrest and senescence with an inability to be passaged serially in vitro. CONCLUSIONS This report represents the first xenograft model of a sacral chordoma line described in the literature and the first cell line established with stable Brachyury expression. The authors propose that Brachyury is an attractive therapeutic target in chordoma and that JHC7 will serve as a clinically relevant model for the study of this disease.
Analgesic efficacy of intranasal butorphanol (Stadol NS) in the treatment of pain after dental impaction surgery.

PURPOSE This study evaluated the safety and efficacy of increasing doses of intranasal butorphanol (Stadol NS, Bristol-Myers Squibb, New York, NY) compared with placebo in controlling moderate to severe pain after removal of bony impacted third molars. PATIENTS AND METHODS This single-dose, double-blind, parallel-group, dose-response trial compared the efficacy and safety of 4 doses of intranasally administered butorphanol tartrate and placebo in controlling moderate to severe pain after the removal of impacted third molars in 151 patients. The study was conducted at 2 sites. The patients were randomly assigned to receive 1 dose of butorphanol tartrate: 0.25 mg (n = 31), 0.5 mg (n = 29), 1.0 mg (n = 30), 2.0 mg (n = 30), or placebo (n = 31). Medication was administered with a metered-dose spray pump. Patients rated pain intensity (PI), pain relief (PAR), pain half gone (PHG), and adverse events at 0.25, 0.5, 1, 2, 3, 4, 5, and 6 hours after treatment. At the end of the study period or before rescue medication (ibuprofen, 400 mg, or acetaminophen, 1,000 mg), patients provided an overall assessment (GLOBAL). RESULTS A linear dose-response regression (P < or = .05) was observed for the means of pain intensity difference (PID), PAR, and PHG at 0.25, 0.5, and 1 hour, and for sum of pain intensity differences (SPID), sum of pain relief (TOTPAR), peak PID and PAR, and GLOBAL evaluation. The 1.0- and 2.0-mg groups experienced greater pain relief compared with placebo (P = .05) during the first hour after drug administration. The 1.0- and 2.0-mg groups had significantly better GLOBAL evaluations than the placebo group, but were not significantly different from placebo for time until remedication (TREMED). Incidence and severity of the most common adverse events were dose-related. Two severe adverse events (drowsiness and dizziness) occurred after the 2.0-mg dose. CONCLUSION Intranasal butorphanol effectively relieved postsurgical dental pain, with a rapid onset within 15 minutes, and seems to be a promising addition to the current armamentarium of opioid analgesics. As with other opioids, it should be used cautiously in an outpatient setting.
Impact of celebrity credibility on advertising effectiveness

Advertisers often make use of endorsers or representatives as trustworthy sources of persuasion for consumers' attitudes. Promotion of products through celebrities is a trendy advertising practice around the world. The present study judged the impact of celebrity credibility on advertising effectiveness in terms of consumer’s attitude towards the advertisement, attitude towards the brand and their purchase intention. This study also explored the differences of respondent’s responses towards the advertisements of brand through famous celebrities as well as unknown celebrities. Different TV advertisements were used for the experiment. Several statistical tools were applied to test the hypotheses and identify significant differences & the proposed relationships among the variables. Overall findings suggests that the respondents considered the famous celebrities of the brand as the most credible celebrities, having positive impact on consumers attitude towards the advertisement, attitude to the brand and their favorable purchase intentions as compare to the unknown celebrity with less credibility.
Psychosocial Traits Characterizing EV Adopters’ Profiles: The Case of Tenerife (Canary Islands)

The aim of this paper is to analyze Rogers-system categories of electric vehicle adopters in Tenerife (Canary Islands) to highlight the psychological factors defining each category. The paper runs a model to calculate willingness to change and willingness to pay for an electric vehicle following the contingent valuation methodology. A survey performed in Tenerife Island collected data from 444 private cars drivers. The survey contained a set of questions on psychological and car-features issues, as well as other items querying the socioeconomic factors and mobility characteristics of the drivers. This paper brings key contributions to the literature. First, it uses two theoretical frameworks to define the categories of innovators from a psychosocial standpoint. Second, the results will usefully inform both policymakers and automaker marketing departments on specific actions to accelerate the uptake of electric vehicles. Our results confirm that electric vehicle adopter categories are similar in proportion and characteristics to those of Rogers’ diffusion of innovation theory, and can be collapsed into two macro-groups of adopters distributed in a 50%–50% split in our sample, i.e., the earlier adopters and the later adopters.