Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of early molecular response in children with chronic myeloid leukemia treated in the French Glivec phase 4 study.

Studies in adults have shown that an early molecular response to imatinib predicts clinical outcome in chronic myeloid leukemia (CML). We investigated the impact of the BCR-ABL1 transcript level measured 3 months after starting imatinib in a cohort of 40 children with CML. Children with a BCR-ABL1/ABL ratio higher than 10% at 3 months after the start of imatinib had a larger spleen size and a higher white blood cell count compared with those with BCR-ABL1/ABL ≤10%. Children with BCR-ABL1/ABL ≤10% 3 months after starting imatinib had higher rates of complete cytogenetic response and major molecular response at 12 months compared with those with BCR-ABL1/ABL >10%. With a median follow-up of 71 months (range, 22-96 months), BCR-ABL1/ABL ≤10% correlated with better progression-free survival. Thus, early molecular response at 3 months predicts outcome in children treated with imatinib for CML. This trial was registered at www.clinicaltrials. gov as #NCT00845221.
Short term heart rate variability for early assessment of autonomic neuropathy in patients with type 2 diabetes mellitus: A comparative cross-sectional study

Background: Cardiovascular autonomic diabetic neuropathy (CADN) is an important diabetes-associated complication. Reduced heart rate variation is the earliest indicator of CADN. Aims: The aim was to study the prospect of using short term heart rate variability (HRV) analysis for early diagnosis of CADN. Settings and Design: The type of this study was hospital-based comparative cross-sectional study. Materials and Methods: A total of 30 asymptomatic, type 2 diabetic male patients with duration of diabetes of 1-5 years with random blood sugar ≥200 mg/dl (11.1 mmol/L) or fasting blood sugar ≥126 mg/dl (7 mmol/L) in the age group of 30-65 years were selected as subjects. Thirty age and sex matched healthy nondiabetics were selected as controls. HRV analysis was performed using electrocardiogram recorded in lead II, at rest, in the supine position for 5 min. Results: Total power, low frequency power, high frequency power, standard deviation of all R-R intervals, root mean square of successive RR-interval differences, number of intervals differing by >50 ms from adjacent interval (NN50), and percentage of NN50 (pNN50) were significantly less in diabetics when compared to nondiabetics (P < 0.05). Conclusion: Data from the study demonstrated that asymptomatic diabetics with <5 years history had already developed autonomic neuropathy. Short term analysis of HRV can be used as a valuable tool for early diagnosis of autonomic neuropathy.
Qualitative study of patients and health‐care professionals' views on the efficacy of the nutrition as medication oral nutrition supplement program

AIM The use of concentrated oral nutrition supplements dispensed in small volumes throughout the day at medication rounds is a common nutrition support strategy. Often termed 'Nutrition as Medication' or NAM, it is associated with excellent rates of patient consumption. However, administration of NAM has been described as suboptimal. The aim of the present study was to identify and explore factors influencing the efficacy of the NAM program from a qualitative perspective. This included exploring issues relating to knowledge, administration and patient consumption from a patient and health professional perspective. METHODS Semistructured interviews with patients (n = 7) and eight focus groups with nursing, medical, pharmacy and dietetic staff (n = 63) were conducted. Interviews were conducted in the workplace and were recorded and transcribed verbatim. Data were analysed from a realist theoretical position using the thematic framework approach. RESULTS Five themes were identified that impact on the efficacy of the NAM program. These include the need for clear role delineation among health professionals regarding responsibility for each aspect of NAM. Other themes that emerged included misconceptions about the importance and relevance of the treatment; perceptions of poor palatability and issues associated with the logistics of providing the supplements within the hospital setting. CONCLUSIONS Dietitians should be aware that there are a range of factors that influence the efficacy of the NAM strategy, including the knowledge and values of individual health professional staff. In addition, increased awareness is required by dietitians regarding the structural barriers to administration and receiving of NAM at the ward level.
Cephalometric evaluation of upper airway in healthy adult population: A preliminary study

Objective: To obtain normative cephalometric data of upper airway in normal adult population. Materials and Methods: Study included 60 healthy subjects, 30 males and 30 females with age range of 18-40 years with normal skeletal profile, no history of sleep-related disorders, obesity. The cephalometric parameters assessed included airway measurements like size of the tongue, soft palate, dimensions of naso, oro, hypopharynx, and relative positions of hyoid bone and vellaculae. Statistical Analysis: Paired t -test was used T-value Results: Significant sex dimorphisms were observed in most of the parameters with the exception of upper airway width and length of soft palate. Conclusions: The data provides preliminary details of upper airway assessment in normal individuals. Further correlations can be drawn with the studies comparing airway dimensions in normal individuals and in subjects with sleep-related disorders.
A step forward back to (induced) fetal.

In this issue of Blood, Zhu et al examine signal transduction of hydroxyurea-induced γ-globin, implicating nuclear factor κB (NF-κB)–mediated activation of the secretion-associated and ras-related (SAR1) signaling protein, which in turn activates the G-protein-associated c-Jun N-terminal kinase (JNK)/Jun pathway.1
The role of pay secrecy policies and employee secrecy preferences in shaping job attitudes

304 © 2018 John Wiley & Sons Ltd w Abstract Although pay secrecy continues to garner attention in human resource management, little research examines how these policies impact employees. Research inconsistently links secretive pay policies to unfavourable outcomes but has yet to consider that employees may have varying attitudes toward these policies. We examine how employee preferences modify the effect that organisational pay secrecy policies have on employee attitudes in a sample of 431 employed adults. To accomplish this goal, we create measures of pay secrecy policies and pay secrecy preferences that each differentiate two facets of pay secrecy: distributive pay non‐disclosure and communication restriction. Polynomial and moderated regression analyses indicated that disparities between employee preferences and organisational pay secrecy policies can reduce job satisfaction and perceptions of informational, interpersonal, and procedural justice under certain circumstances. These results simultaneously highlight the importance of employee attitudes toward pay secrecy policies and the challenges human resource practitioners face in managing employees with diverse preferences.
Nuclear hypersegmentation of neutrophils, eosinophils, and basophils due to hydroxycarbamide (hydroxyurea).

[Figure][1] The patient was a 72-year-old man who had a diagnosis of polycythemia vera (PV) in 2010. A JAK2 V617F mutation was positive. Hydroxycarbamide (hydroxyurea [HU]) was started at 500 mg and gradually increased to 1250 mg daily. His recent complete blood count showed the following:
Y-MAC: An Energy-Efficient Multi-channel MAC Protocol for Dense Wireless Sensor Networks

As the use of wireless sensor networks (WSNs) becomes widespread, node density tends to increase. This poses a new challenge for medium access control (MAC) protocol design. Although traditional MAC protocols achieve low-power operation, they use only a single channel which limits their performance. Several multi-channel MAC protocols for WSNs have been recently proposed. One of the key observations is that these protocols are less energy efficient than single-channel MAC protocols under light traffic conditions. In this paper, we propose an energy efficient multichannel MAC protocol, Y-MAC, for WSNs. Our goal is to achieve both high performance and energy efficiency under diverse traffic conditions. In contrast to most of previous multi-channel MAC protocols for WSNs, we implemented Y-MAC on a real sensor node platform and conducted extensive experiments to evaluate its performance. Experimental results show that Y-MAC is energy efficient and maintains high performance under high-traffic conditions.
Sorption and dissipation of testosterone, estrogens, and their primary transformation products in soils and sediment.

Concern over the potential negative ecological effects of steroid hormones from human- and animal-derived wastes has resulted in an increased interest regarding the mobility and persistence of these compounds in the environment. Batch experiments were conducted to examine the simultaneous sorption and dissipation of three reproductive hormones (testosterone, 17beta-estradiol, and 17alpha-ethynyl estradiol) in four midwestern U.S. soils and one freshwater sediment. Sorption isotherms were generated by measuring aqueous concentrations and by extracting the sorbed parent chemical or transformation products (e.g., estrone, androstenedione). Apparent sorption equilibrium is reached within a few hours. Measured sorption isotherms for the three parent chemicals and their principal transformation products were generally linear. Average organic carbon normalized sorption coefficients (K(oc)) resulted in standard deviations of less than 0.2 log units and were consistent with reported aqueous solubilites and octanol-water partition coefficients, indicating hydrophobic partitioning as the dominant sorption mechanism. Large log K(oc) values (approximately 3-4) suggest that leaching from soils will be limited, runoff of soil- and land-applied biosolids are the most likely inputs into surface waters, and that a significant fraction of these compounds will be associated with sediments. Half-lives for hormone dissipation in the aerobic soil and sediment slurries estimated assuming pseudo first-order processes ranged from a few hours to a few days with testosterone having the shortest half-life.
Low nitrogen losses with a new source of nitrogen for cultivation of conifer seedlings.

Losses of nitrogen (N) when cultivating plants may cause a number of adverse environmental effects. N losses from conifer nurseries, for instance, may have a considerable impact on the local environment, and studies indicate that the bulk of added N is not recovered in the cultivated plants. This study was conducted to obtain insight into the causes of the low recovery and to test an alternative N fertilizer. Hence, growth of the economically important Scots pine (Pinus sylvestris (L). ) seedlings and the recovery of different forms of added nitrogen (N) were investigated in a greenhouse experiment. Containerized seedlings were grown in peat for one summer, with two different N fertilizers, one organic (arginine) and one inorganic (a commercial fertilizer (CF) containing a mixture of ammonium and nitrate) each at an N concentration of 3 mM. At the end of the growth period, some seedlings were labeled with solutions containing either U-[13C6], [15N4]-arginine, (15NH4)2SO4, or K15NO3 supplied to the growth substrate. Labeled seedlings were harvested 1 h, 5 days, and 19 days after tracer addition, and the recovery of each added nitrogen source in both the seedlings and the growth substrate was measured. The retention of the three N forms during discharge of solutions from the growth substrate, peat, was tested in a separate experiment. Arginine-fed seedlings grew better and had higher needle N concentrations than the CF-fed seedlings. Isotopic data showed that the arginine treatment gave significantly higher N recoveries (80%) compared to the CF treatment (50%). The low recovery of N in the CF treatment was largely due to very low recovery (30%) of NO3- -N. The retention of the different N forms during discharge of solutions from the growth substrate was highest for arginine, somewhat lower for NH44+, and very low for NO3-. The high rate of seedling growth and the small nitrogen losses observed when using arginine suggest that this amino acid may be an efficient and environmentally favorable N source for cultivating conifer seedlings.
In situ mobilization of colloids and transport of cesium in Hanford sediments.

Radioactive waste, accumulated during Pu production, has leaked into the subsurface from underground storage tanks at the U.S. Department of Energy's Hanford site. The leaking solutions contained 137Cs and were of high ionic strength. Such a tank leak was simulated experimentally in steady-state flow experiments with packed Hanford sediments. The initial leak was simulated by a 1 M NaNO3 solution, followed by a decrease of ionic strength to 1 mM NaNO3. Cesium breakthrough curves were determined in both 1 M and 1 mM NaNO3 background. Colloidal particles were mobilized during the change of ionic strength. Mobilized colloids consisted mainly of quartz, mica, illite, kaolinite, and chlorite. Electrophoretic mobilities of colloids in the eluent solution were -3(microm/s)(V/cm) and increased to less negative values during later stages of mobilization. Mobilized colloids carried a fraction of the cesium along. While transport of cesium in 1 M NaNO3 background was much faster than in 1 mM NaNO3, cesium attached to colloids moved almost unretarded through the sediments. Cesium attached to mobilized colloids was likely associated with high affinity sorption sites on micas and illites.
Fibromyalgia Tender Point Pain: A Double-Blind, Placebo-Controlled Pilot Study of Music Vibration Using the Music Vibration Table ™

Objectives: To determine the immediate effects of music and musically fluctuating vibration on tender point pain in patients with fibromyalgia syndrome [FMS], because it was known that musically fluctuating vibration in the 60–300 Hz frequency range stimulates Pacinian corpuscles [PC]. It was speculated that PC signals might suppress nociceptive transmission via adenosine acting on P1-purinergic receptors at the spinal cord level.Methods: Fibromyalgia syndrome [FMS] patients [American College of Rheumatology criteria] were randomly assigned to one of two treatment groups, either musically fluctuating vibration [60–300 Hz] as an active intervention, or a sinusoidal vibration [20 Hz] as the placebo/control treatment. Primary clinical variables, measured before and after treatment sessions, included a visual analog scale [VAS] for pain, the Tender Point Index [TPI], and the average algometric Pain Threshold [TPA]. Results: Twenty-six FMS patients participated in the study. The demographics, FMS history, and s.
Color, phenolics, and antioxidant activity of blackberry (Rubus glaucus Benth.), blueberry (Vaccinium floribundum Kunth.), and apple wines from Ecuador.

Seventy wines were produced in Ecuador under different processing conditions with local fruits: Andean blackberries (Rubus glaucus Benth.) and blueberries (Vaccinium floribundum Kunth.) and Golden Reinette apples. Wines were evaluated for antioxidant activity (AA) using the radical scavenging capacity (DPPH) method, total phenolic content (TPC) using the Folin-Ciocalteu method, total monomeric anthocyanins (TMAs) using the pH differential test, and color parameters using VIS-spectrophotometry. For blackberry wines, ellagitannins and anthocyanins were also analyzed using high-performance liquid chromatography with diode-array detection (HPLC-DAD). Apples wines (n = 40) had the lowest TPC (608 ± 86 mg/L) and AA (2.1 ± 0.3 mM Trolox). Blueberry wines (n = 12) had high TPC (1086 ± 194 mg/L) and moderate AA (5.4 ± 0.8 mM) but very low TMA (8 ± 3 mg/L), with a color evolved toward yellow and blue shades. Blackberry wines (n = 10) had the highest TPC (1265 ± 91 mg/L) and AA (12 ± 1 mM). Ellagitannins were the major phenolics (1172 ± 115 mg/L) and correlated well with AA (r = 0.88). Within anthocyanins (TMA 73 ± 16 mg/L), cyanidin-3-rutinoside (62%) and cyanidin-3-glucoside (15%) were predominant. Wines obtained by cofermentation of apples and blackberries (n = 8) showed intermediate characteristics (TPC 999 ± 83 mg/L, AA 6.2 ± 0.7 mM, TMA 35 ± 22 mg/L) between the blackberry and blueberry wines. The results suggest that the Andean berries, particularly R. glaucus, are suitable raw materials to produce wines with an in vitro antioxidant capacity that is comparable to red grape wines.
ST1926 repression of Tax: ATL targeted treatment?

In this issue of Blood , El Hajj et al report that the synthetic retinoid ST1926 downregulates the oncoprotein Tax and induces apoptosis and growth arrest of adult T-cell leukemia (ATL) cells. [1][1] ! [Figure][2] Schematic representation of ST1926 repression of Tax and apoptosis of ATL cells
An analysis of predictive markers for intracranial haemorrhage in warfarinised head injury patients

Introduction Minor head injury in older patients on warfarin may present in a variety of ways that often fall outside the remit of conventional guidelines. The aim of this study was to determine the relative risks for intracranial haemorrhage (ICH) in patients with subtherapeutic, therapeutic and supratherapeutic INR levels, in addition to the relative risks for the common symptoms at presentation. Methods The notes were retrospectively reviewed of all patients who had a CT scan requested by the emergency department over a 2-year period (January 2008 to December 2009) and from these warfarinised head injuries were identified. Results 82 warfarinised head injury patients were identified from 3338 requested CT scans. 12 of these patients (15%) had evidence of ICH on the CT. 72 patients had their INR checked (88%) and the RR of ICH for the INR subgroups were calculated: INR <2 (RR 1.89; 95% CI 0.65 to 5.55); INR 2–3 (RR 0.84; 95% CI 0.27 to 2.64); and INR >3 (RR 0.53; 95% CI 0.13 to 2.29). The greatest proportion of those with ICH (42%) had a subtherapeutic INR. 2 out of the 12 patients (17%) were found to have intracranial bleeding despite not meeting the criteria for a CT scan according to the NICE guidelines. Conclusion The results of the INR subgroup analysis suggest that a subtherapeutic INR may not be protective against ICH in patients with minor head injury.
SOCIAL SUPPORT IN PREGNANCY: DOES IT HAVE LONG-TERM EFFECTS?

Abstract This paper describes the results of a 7-year follow-up survey of families who took part in a randomized controlled trial of research midwife-provided social support in pregnancy in 1986–88. Analysis of data 6 weeks and 1 year after delivery indicated that families offered the social support intervention had better health outcomes than those in the control group. A further wave of data collection using postal questionnaires was undertaken when the index children were aged between 6 and 8 years. The findings indicated that the initial advantage shown by the intervention group appeared to have been maintained. At 7 years, there were significant differences favouring the families in the intervention group in the health and development outcomes of the children, and the physical and psychosocial health of the mothers. The results confirm the health-promoting effect of social support, and the importance of providing supportive care within the routine maternity services, not only as a means to improve wo.
In vivo activity of 11β‐hydroxysteroid dehydrogenase type 1 and free fatty acid‐induced insulin resistance

Introduction Free fatty acids (FFAs) induce hepatic insulin resistance and enhance hepatic gluconeogenesis. Glucocorticoids (GCs) also stimulate hepatic gluconeogenesis. The aim of this study was to investigate whether the FFA‐induced hepatic insulin resistance is mediated by increased activity of hepatic 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1), accompanied by elevated hepatic cortisol levels.
Usefulness of nefopam in treating pain of severe uncomplicated renal colics in adults admitted to emergency units: a randomised double-blind controlled trial. The ‘INCoNU’ study

Background Renal colic pain is a frequent cause of emergency department admissions (1–2% of admissions). It is extremely painful, often requiring intravenous morphine titration. The aim of this study was to estimate the effect of adding nefopam to ketoprofen upon subsequent morphine consumption and the time needed to achieve adequate analgesia in renal colic. Methods The authors undertook a prospective, monocentric, randomised, double-blind, placebo-controlled, parallel-group study, using an intent-to-treat analysis. Patients admitted to the emergency department for suspected hyperalgesic (evaluated with a visual analogue scale (VAS)) renal colic were enrolled in the study. They were administered an initial treatment of ketoprofen before being randomly assigned to either the placebo or nefopam group. Results Thirty patients admitted to the emergency department were enrolled in the study. Morphine analgesia was necessary for 10 patients (66.6%) (95% CI 40% to 90%) in the nefopam group and 8 (53.3%) (95% CI 30% to 80%) in the placebo group, with no statistically significant difference found (difference 13.3%, 95% CI −51% to 24%). The time needed to achieve adequate analgesia in the case of morphine titration was 8.3 min (95% CI 4.2 to 12.5) in the nefopam group and 9 min (95% CI 2.7 to 15.3) in the placebo group, with no statistically significant difference (difference 0.7, 95% CI 7.25 to 8.58). Conclusion This study did not reveal any significant difference between nefopam and placebo. This may be due to lack of statistical power or lack of effectiveness. Clinical trial registration number http://ClinicalTrials.gov ID number NCT00639574.
The Use of Complementary and Alternative Medicine Practices Among Australian University Students

A survey of 518 university students in Australia was conducted to gain a better understanding of complementary and alternative medicine (CAM) use. Results indicated that 81.1% of the students used at least 1 of 24 CAM practices. Top practices were relaxation, massage, herbs, art therapy, and prayer. The most common health reasons for using CAM were stress or psychosomatic issues (i.e., anxiety, allergies, stress, and headaches). Other reasons reflected a positive perspective: lifestyle, availability, and holistic health. Students who did not use CAM cited economic factors as the chief reason. Thus, these results offer further insights into the growing worldwide use of CAM.