Miracle-dz/UniFAR-FTUs huggingface dataset:
Variability and reactive changes of the peripheral blood flow, blood pressure and of the electrical behavior of the heart

Shortly after legalization of the Slovak Academy of Sciences, (SAS) at the turn of 1953, Prof. Ladislav Derer established at the 1 st Clinic of Internal Medicine of the Faculty of Medicine Comenius University, the Laboratory of Clinical Physiology of the Higher Nervous Activity in Man SAS. It was one among other laboratories, representing the historical base of the present Institute of Normal and Pathological Physiology SAS. The Laboratory was set up to promote the research in the field of psychophysiology and of human cardiovascular physiology, aimed namely at the peripheral vasomotor activity in man, at the physiological variability, reactivity and developmental aspects of blood pressure, with respect to hypertension and at the physiological, clinical and model studies of the cardiac electric field. Shortly an experimental team studying the peripheral vasomotor regulatory mechanisms in dogs joined temporarily the Laboratory. The a
Analysis of Class II patients, successfully treated with the straight-wire and Forsus appliances, based on cervical vertebral maturation status.

OBJECTIVE To assess skeletal and dental changes in patients successfully treated with the Forsus appliance based on cervical vertebral maturation status. METHODS Forty-seven Class II patients, successfully treated with the Forsus appliance, were divided into peak and postpeak growth groups determined immediately prior to Forsus placement. The mean (SD) ages of the peak and postpeak groups were 13.4 (1.0) and 14.1 (1.3) years, respectively. Superimpositions of initial, Forsus placement, Forsus removal, and final cephalometric radiographs were completed, allowing the measurement of changes during three treatment phases. RESULTS There were no significant differences between groups during treatment phase 1 (alignment/leveling), with both groups demonstrating a worsening of the Class II molar relationship. However, during treatment phase 2 (Class II correction), patients within the peak group demonstrated significantly higher mean apical base, mandibular and molar changes, and an increased rate of change compared with those in the postpeak group. No significant differences were observed during treatment phase 3 (detail/finishing). CONCLUSIONS Following an initial worsening of the Class II molar relationship as a result of straight-wire appliance effects, Forsus appliance treatment initiated during cervical vertebral maturation status (CS) 3-4 elicits more effective and efficient correction of Class II molar relationships than when initiated during CS 5-6. Data support that these effects are due mainly to maxillary skeletal and dentoalveolar restraint during a period of more rapid mandibular growth.
Diffusion of Photochemically Generated Intermediate Radicals in Water-Ethanol Mixed Solvents

Diffusion processes of intermediate radicals created by the photoinduced hydrogen abstraction reactions of benzoquinone (BQ) and acetophenone (AP) in ethanol−water mixed solvents are studied by using the transient grating (TG) method. The electrically neutral radicals and the anion radicals are created selectively by adding sodium hydroxide (NaOH) or sulfuric acid (H2SO4) to the solutions. The intermediate species and the chemical stability of the radicals were monitored by the transient absorption and time-resolved EPR methods. The diffusion constants (D) of the radicals and the parent molecules are determined simultaneously. D of the anion radicals are similar to those of the neutral radicals in any mixtures of the solvents. D of the neutral and anion radicals (DR) are much smaller than those of the parent molecule (DP) in ethanol (DP/DR ∼ 2.8 for BQ and DP/DR ∼ 2.1 for AP in ethanol), while DP become closer to DR with increasing water content in the solvent (DP/DR ∼ 1.3 for BQ and QP in 90% water solut.
The Receptor Tyrosine Kinase Ror2 Associates with the Melanoma-associated Antigen (MAGE) Family Protein Dlxin-1 and Regulates Its Intracellular Distribution*

The mammalian Ror family receptor tyrosine kinases, Ror1 and Ror2, play crucial roles in developmental morphogenesis. Although the functions of Ror1 and Ror2 are redundant, Ror2 exhibits more specific functions during development. We show that when expressed in mammalian cells, Ror2, but not Ror1, associates with the melanoma-associated antigen (MAGE) family protein, Dlxin-1, which is known to bind to the homeodomain proteins Msx2 and Dlx5 and regulate their transcriptional functions. This association requires the cytoplasmic C-terminal region of Ror2, containing proline-rich and serine/threonine-rich domains, and the C-terminal necdin homology domain of Dlxin-1. Interestingly, the cytoplasmic C-terminal region of Ror2 is missing in patients with brachydactyly type B. Interestingly, transient expression and immunohistochemical analyses reveal that both Dlxin-1 and Msx2 are co-localized in the nuclei in the absence of Ror2. In the presence of Ror2, Dlxin-1 is co-localized with Ror2 at the membranous compartments and Msx2 is retained in the nuclei. It was also found that the majority of cellular Dlxin-1 is retained in the membrane fractions of wild-type but not Ror2–/– mouse embryonic fibroblasts. Furthermore, we show that transcriptional activity of Msx2, irrespective of Ror2 kinase activity, is regulated by ectopic expression of Ror2 using a reporter plasmid containing the WIP element. Thus, Ror2 sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of Msx2.
The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6&agr;–aPKC&zgr; that are affected by Lgl1 phosphorylation

ABSTRACT Non-muscle myosin IIA (NMII-A) and the tumor suppressor lethal giant larvae 1 (Lgl1) play a central role in the polarization of migrating cells. Mammalian Lgl1 interacts directly with NMII-A, inhibiting its ability to assemble into filaments in vitro. Lgl1 also regulates the cellular localization of NMII-A, the maturation of focal adhesions and cell migration. In Drosophila, phosphorylation of Lgl affects its association with the cytoskeleton. Here we show that phosphorylation of mammalian Lgl1 by aPKC&zgr; prevents its interaction with NMII-A both in vitro and in vivo, and affects its inhibition of NMII-A filament assembly. Phosphorylation of Lgl1 affects its cellular localization and is important for the cellular organization of the acto-NMII cytoskeleton. We further show that Lgl1 forms two distinct complexes in vivo, Lgl1–NMIIA and Lgl1–Par6&agr;–aPKC&zgr;, and that the formation of these complexes is affected by the phosphorylation state of Lgl1. The complex Lgl1–Par6&agr;–aPKC&zgr; resides in the leading edge of the cell. Finally, we show that aPKC&zgr; and NMII-A compete to bind directly to Lgl1 at the same domain. These results provide new insights into the mechanism regulating the interaction between Lgl1, NMII-A, Par6&agr; and aPKC&zgr; in polarized migrating cells.
Voice quality variation in Scottish adolescents: Gender versus geography

Given the importance of voice quality in signalling personal identity and social group membership, effective control of voice features may become especially important during adolescence, yet this has to be achieved in the context of significant physical changes within the speech production system. Most previous research has focussed on phonation, but this study used Vocal Profile Analysis (VPA) [11] for perceptual analysis of both laryngeal and vocal tract voice settings in Scottish adolescents, in order to identify voice quality markers of gender and geographical background in this age group. VPA analysis was carried out for 76 speakers (31 male; 45 female), drawn from three geographically distinct areas of Scotland. Some of the observed variation in voice quality (especially phonatory settings) may be attributable to physical changes associated with puberty, but other setting adjustments seem more likely to be sociophonetic in origin.
Linuron sorption-desorption in field-moist soils.

Pesticide sorption or binding to soil is traditionally characterized using batch slurry techniques. The objective of this study was to determine linuron sorption in field-moist or unsaturated soils. Experiments were performed using low-density (i.e., 0.25 g mL(-)(1)) supercritical carbon dioxide to remove linuron from the soil water phase, thus allowing calculation of sorption coefficients (K(d)) at low water contents. Both soil water content and temperature influenced sorption. K(d) values increased with increased water content, if less than saturated. K(d) values decreased with increased temperature. K(d) values for linuron sorption on silty clay and sandy loam soils at 12% water content and 40 degrees C were 3.9 and 7.0 mL g(-)(1), respectively. Isosteric heats of sorption (DeltaH(i)) were -41 and -35 kJ mol(-)(1) for the silty clay and sandy loam soils, respectively. The sorption coefficient obtained using the batch method was comparable (K(f) for sandy loam soil = 7. 9 microg(1)(-)(1/)(n)() mL(1/)(n)() g(-)(1)) to that obtained using the SFE technique. On the basis of these results, pesticide sorption as a function of water content must be known to more accurately predict pesticide transport through soils.
Youth Smoking Uptake Progress: Price and Public Policy Effects

The differential effects of cigarette prices, smoking restrictions, and youth access laws on five stages of smoking uptake among U.S. high school students is examined. The results of the generalized ordered logit indicate that higher cigarette prices are negatively related to being further on the smoking uptake continuum and that their impact is increasing with the probability of becoming an established smoker increases. Compliance with youth access laws may slow the uptake process. This effect is strongest for students at the last stages of smoking uptake. Higher cigarette prices and policies reducing youth access to cigarettes can interrupt adolescents' progress toward becoming daily, addicted smokers.
Measurement of the isolated diphoton cross section in pp collisions at √s = 7 TeV with the ATLAS detector

The ATLAS experiment has measured the production cross section of events with two isolated photons in the ﬁnal state, in proton-proton collisions at ﬃﬃﬃ s p ¼ 7 TeV . The full data set acquired in 2010 is used, corresponding to an integrated luminosity of 37 pb (cid:1) 1 . The background, consisting of hadronic jets and isolated electrons, is estimated with fully data-driven techniques and subtracted. The differential cross sections, as functions of the di-photon mass ( m (cid:1)(cid:1) ), total transverse momentum ( p T ;(cid:1)(cid:1) ), and azimuthal separation ( (cid:1) (cid:2) (cid:1)(cid:1) ), are presented and compared to the predictions of next-to-leading-order QCD.
[Role of EuroSCORE and SinoSCORE in prediction of early postoperative quality of life in patients after coronary artery bypass surgery].

OBJECTIVE To investigate the predicting value of European system for cardiac operative risk evaluation (EuroSCORE) and sino system for coronary operative risk evaluation (SinoSCORE) in early quality of life of patients after coronary artery bypass surgery (CABG). METHODS A total of 218 consecutive patients who underwent CABG from March 2010 to January 2013 were evaluated with both systems before operation. Health related quality of life (QoL) was estimated by using 36-item short form health survey (SF-36) preoperatively and postoperatively in order to evaluate the predicting value of the two systems in early post-operative QoL. Calibration was evaluated by Hosmer-l,emeshow goodness-of-fit test.Discrimination was tested by determining the area under the receiver operating characteristic (ROC) curve. RESULTS There was no significant difference between the accumulation of the EuroSCORE and SinoSCORE in the all patients (t=-0.904, P=0.368), When using Wilcoxon test on life quality in the preoperative and postoperative patients respectively,the data showed that the quality of life improved significantly in various dimensions of the postoperative patients (Z=-2.886, P<0.001). Except for bodily pain (BP) and mental health (MH), statistically significant correlation was found between the preoperative risk evaluation scores and the postoperative QoL scores (r:-0.203 to -0.493, P<0.05). Logistic regression analyses indicated that both the scores emerged as the independent predictor for a relatively worse QoL (OR>1, P<0.05). Furthermore, the EuroSCORE predicted the outcome with a higher OR. For SinoSCORE the Hosmer-Lemeshow test was significant (P=0.628) and the area under ROC curve was 0.754. For the EuroSCORE the Hosmer-Lemeshow test was significant (P=0.538) and the area under ROC curve was 0.854. CONCLUSION Both EuroSCORE and SinoSCORE could be viewed as a predictor for several aspects of postoperative QoL, while EuroSCORE might have a greater predicting value.
Longitudinal Studies of Japanese Encephalitis Virus Infection in Vector Mosquitoes in Kurnool District, Andhra Pradesh, South India

ABSTRACT A 4-yr (2002–2006) entomological study was carried out in Kurnool district, Andhra Pradesh state, south India, to identify the mosquito vectors of Japanese encephalitis virus (family Flaviviridae, genus Flavivirus, JEV). In total, 37,139 female mosquitoes belonging five genera and 18 species resting on vegetation were collected in villages and periurban areas at dusk. Mosquito species composition and pattern of JEV infection in mosquitoes varied in periurban and rural areas. In periurban area, Culex gelidus Theobald was abundant, msking up 49.7% of total catch followed by Culex tritaeniorhynchus Giles (44.5%). In rural area, Cx. tritaeniorhynchus was predominant, making up 78.9% of total catch followed by Culex quinquefasciatus Say (10.8%), Anopheles subpictus Grassi (7.1%), and Cx. gelidus (1.1%). In light trap collections, Cx. gelidus and Cx. tritaeniorhynchus predominated in periurban and rural areas, respectively. Of 50,145 mosquitoes screened JEV isolations were made only from Cx. gelidus and Cx. tritaeniorhynchus. Based on high abundance and frequent JEV isolation, Cx. tritaeniorhynchus was found to be the principal vector in both areas, whereas Cx. gelidus plays a secondary vector role in periurban areas only.
Stock Price Manipulation: Prevalence and Determinants

We empirically analyze the prevalence and economic underpinnings of closing price manipulation and its detection. We estimate that ∼1% of closing prices are manipulated, of which only a small fraction is detected and prosecuted. We find that stocks with high levels of information asymmetry and mid to low levels of liquidity are most likely to be manipulated. A significant proportion of manipulation occurs on month/quarter-end days. Manipulation on these days is more likely in stocks with high levels of institutional ownership. Government regulatory budget has a strong effect on both manipulation and detection.
Magnetic Resonance Angiography of Pulmonary Veins: Implications for Catheter Ablation of Atrial Fibrillation

Introduction: Catheter ablation of atrial fibrillation (AF) requires exact anatomical information about pulmonary venous (PV) ostia. In this study, anatomy of pulmonary veins (PVs) was assessed using three‐dimensional (3D) reconstructions of magnetic resonance angiography (MRA).
Is topical minoxidil solution effective on androgenetic alopecia in routine daily practice?

Objectives: Minoxidil solution stimulates hair growth in androgenetic alopecia. In order to maintain any beneficial effect, applications must continue indefinitely. The purpose of this study was to evaluate the ratio of patients who were satisfied with the drug and continued to use it versus those who were displeased and did not continue their treatment, and the reasons for the discontinuation. Methods: A total of 1495 men aged 20–40 years who suffered from androgenetic hair loss were selected among patients who were referred to two private dermatologists. They were subjected to treatment with 5% topical minoxidil solution. These patients were treated with no difference from the routine office patients. Factors such as the duration of treatment, adverse effects, the patient's satisfaction and the causes of treatment cessation were also closely studied. Results: Almost all the patients gradually avoided continuing the treatment. Only in a few patients was the cessation of medication due to adverse effects. The causes of discontinuation in the majority of patients were the low effect of medication and an aversion to this topical treatment method. Conclusions: The insignificant cosmetic effect of minoxidil solution caused discontinuity of treatment among almost all patients.
Acceptance-based therapies for treatment of chronic pain : a systematic review

Acceptance-based therapies as Mindfulness-Based Stress Reduction (MBSR), Mindfulness-Based Cognitive Therapy (MBCT) and Acceptance and Commitment Therapy (ACT) are alternative treatments for Cognitive Behavioral Therapy (CBT) for chronic pain. The objective of this review was to evaluate the effectiveness of acceptance-based therapies on the outcome measures quality of life, depression and anxiety of chronic pain patients. A systematic review was conducted of randomized controlled trials (RCT’s) and clinical controlled trials (CCT’s) from three databases. Twenty-six studies (22 RCT’s and 4 CCT’s) met the inclusion criteria. In total, 1747 chronic pain patients were included. This review reported evidence for the effectiveness of acceptance-based therapies. Acceptance-based interventions are effective for the treatment of chronic pain but seem not superior to active treatments like CBT. MBSR seems to have an inferior effect on depression compared to ACT or MBCT. In addition, ACT may have a superior effect to MBSR and MBCT on anxiety. Only few studies reported significant follow-up effects. It seems that the pre-post effects are not preserved. A meta-analysis to compare the quantitative results of studies would be more validated. In addition, more insight in the factors that create positive long-term effects is required.
Cross Social Media Recommendation

The proliferation of rich social media data revolutionizes the way people perceive and understand the world. Unfortunately, so far, there does not exist a single social media system that efficiently globalizes users around the world. Two well-known social media systems, Twitter and Facebook, are strictly blocked in mainland China for political reasons, which means 21.97% of Internet users are excluded from these systems. Similarly, the second-largest microblogging system in the world, Sina Weibo, features a default system language of Chinese, which rules out many users from other countries. This creates what we call language, network, and culture bubbles. As a result, if we are interested in modeling the knowledge of the world, all research findings based on a single social media system (within a bubble) can be biased, and the social networks or knowledge networks generated from a single system or social community cannot fully represent people from around the world. In this study, we generate a pseudo-social heterogeneous network - Pseudo Global Social Media Network (PGSMN), which bridges the topics of Twitter and Weibo. On this network, all Weibo and Twitter nodes are interconnected via an interim knowledge layer, and user or topic nodes from Twitter can randomly walk to the nodes on Weibo (via different kinds of paths), and vice versa, which enables cross-network information recommendation and knowledge globalization.
Genome‐scan for loci involved in cleft lip with or without cleft palate in consanguineous families from Turkey

Cleft lip with or without cleft palate (CL/P) is a common congenital anomaly, with birth prevalence ranging from 1/500 to 1/1,000. A number of genetic loci have shown positive linkage or association results in European Caucasian populations. The purpose of the current study was to assess whether any of those loci have positive results in Turkish Caucasian CL/P families, and to perform a 10 cM genome scan to identify other regions potentially containing cleft susceptibility loci. Eighteen affected individuals with consanguineous parents were identified as part of our on‐going studies of orofacial clefts in Ankara, Turkey. Genotyped were 383 genome‐scan markers, and 70 additional markers, including markers in six candidate loci or regions on chromosomes 2, 4, 6, 14, 17, and 19 (TGFA, D4S175, F13A1, TGFB3, D17S250, and APOC2) that have been implicated in other studies of families with orofacial clefting. LOD scores (two point and multiple point) and family‐based association statistics (TDT) were calculated between each of the markers and CL/P. For the LOD score calculations, an autosomal recessive model was assumed for the inheritance of CL/P. Of the six candidate markers, significant TDT results were obtained with TGFA (P = 0.05). The most statistically significant multipoint results from the linkage genome scan were between putative genes controlling risk of CL/P and regions on chromosomes 4, 10, 12, and 15 (maximum multipoint HLOD's of 1.25, 1.30, 2.73, and 1.28 respectively). These results demonstrate the power of small numbers of families with inbred probands to detect linkage and association. © 2003 Wiley‐Liss, Inc.
The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure

Exposure to cigarette smoke (CS) is linked to the development of respiratory diseases, and there is a need to understand the mechanisms whereby CS causes damage. Although animal models have provided valuable insights into smoking-related respiratory tract damage, modern toxicity testing calls for reliable in vitro models as alternatives for animal experimentation. We report on a repeated whole mainstream CS exposure of nasal and bronchial organotypic tissue cultures that mimic the morphological, physiological, and molecular attributes of the human respiratory tract. Despite the similar cellular staining and cytokine secretion in both tissue types, the transcriptomic analyses in the context of biological network models identified similar and diverse biological processes that were impacted by CS-exposed nasal and bronchial cultures. Our results demonstrate that nasal and bronchial tissue cultures are appropriate in vitro models for the assessment of CS-induced adverse effects in the respiratory system and promising alternative to animal experimentation.