Miracle-dz/UniFAR-FTUs huggingface dataset:
Survival and Prognostic Factors in Mixed Cryoglobulinemia: Data from 246 Cases

Introduction: The clinical and therapeutic management of mixed cryoglobulinemia (MC) remains a subject of controversy. In addition, most studies have not recorded the long-term follow-up and the outcome of these cases. Material and Methods: We enrolled 246 patients affected by MC who were consecutively admitted to our Department from January 1993 to February 2013. Clinical and biological data had been recorded until June 2014. Results: The median age (at diagnosis) was 60 years (range 26–83). The aetiology was HCV in 95% of patients, HBV in 3% and “essential” in 2%. HCV genotype was 1b in 57%, genotypes 2–3 in 43%. MC was Type II in 203 of the cases (87%) and Type III in 52 (13%). The most frequent clinical manifestations were purpura (72%), chronic liver disease (70%), glomerulonephritis (35%), arthralgias (58%), peripheral neuropathy (21%), non-Hodgkin lymphoma (15%) and cutaneous ulcers (3%). Purpura, arthralgias, peripheral neuropathy, glomerulonephritis and non-Hodgkin lymphoma were more frequently observed in Type II than in Type III MC (p < 0.05). Treatments were interferon (IFN) or Pegilated-IFN (PEG-IFN) alone or plus Ribavirin (RIBA) in 101 cases, steroids with or without alkylating agents in 33 cases, Rituximab in 8 patients. The complete clinical, virological and immunological responses were associated with PEG-IFN plus RIBA. Severe infections were associated with renal failure. At 10 years, the overall survival rate was 71% in Type II MC and 84% in Type III (p < 0.053). Conclusions: From our data, antiviral therapy is the first-line therapy in HCV-related MC, whereas steroids, alkylating agents and Rituximab should be considered as a second-line therapy. Given the heterogeneity of the disease, the role of these different therapeutic strategies should be checked in randomized controlled trials.
Discontinuation of antiepileptic drugs after successful surgery: who and when?

Surgery is a highly effective treatment for some specific types of refractory epilepsy and once seizure freedom is achieved many patients and clinicians have to ponder whether to taper or discontinue antiepileptic drugs (AEDs). However, there is no standard practice or guidelines and practices vary widely. The few studies that have addressed this question are retrospective and lack randomised, controlled comparisons, making it difficult to draw any solid inferences. This review examines this topic by analysing key data based on the following: controlled studies which compare outcomes in patients with either withdrawn or unmodified AEDs after epilepsy surgery, non-controlled studies, information from meta-analyses and systematic reviews, surveys of clinical practice, and other relevant reviews. Between 12 and 32% of patients had seizure relapse following tapering or discontinuation of AEDs, which was not significantly different from 7 to 45% in patients without AED modification. In the event of seizure relapse upon tapering of AEDs, 45–92.3% restarted AED treatment and regained seizure freedom. The most consistent risk factors for seizure relapsewere: age older than 30 years at the time of surgery, persistent auras, early drug tapering, seizure recurrence before a reduction of drugs, normal MRI, a longer period with epilepsy, absence of hippocampal sclerosis, and the presence of interictal discharges on EEG after surgery.
Parkinson's disease treatments: focus on transcranial direct current stimulation (tDCS)

php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Journal of Parkinsonism and Restless Legs Syndrome 2017:7 55–70 Journal of Parkinsonism and Restless Legs Syndrome Dovepress
Effect of Different Flooring Designs on the Performance and Foot Pad Health in Broilers and Turkeys

Simple Summary The contact of the birds’ feet with litter and their excreta during the fattening period might lead to reduced body weight, carcass weight, feed intake, and impaired foot pad health in poultry. This study was performed to evaluate the influence of different flooring designs with reduced (50% or 100% slatted floors) contact to the excreta on the above-mentioned parameters in the fattening of broilers and turkeys. The provision of litter on the floor had no relevant effect on foot pad health in broilers. Using fully-slatted flooring in fattening turkeys led to a higher body weight, while reducing incidence of injuries of foot pads. It is, therefore, necessary to consider how a similar excellent litter quality can be achieved in basically littered husbandry systems common in Europe. Abstract Litter quality has a significant influence on the performance and foot pad health in poultry. The objective of this study was to evaluate the effects of different types of flooring designs on the performance and foot pad health in fattening broilers and turkeys. Three trials were conducted for each species using a total of 720 Ross 308 broilers and 720 Big 6 turkeys. After day seven, animals were randomly assigned to four groups with three subgroups each: G1—floor pens with litter, G2—floor pens with litter and floor heating, G3—partially-slatted flooring, including a littered area, and G4—fully-slatted flooring with a sand bath (900 cm2). Animals of both species had a significantly higher final body weight at dissection (day 36) after being reared on fully-slatted floors compared to common littered floors. In turkeys, the feed conversion ratio was worse in G4 (1.53 ± 0.04) than in G1 (1.47 ± 0.02) and G2 (1.48 ± 0.03). Water to feed ratio was significantly higher in G2 than other groups. Turkeys’ foot pad health was significantly better in G4 than in other groups beginning at day 21. In turkeys, platforms with slatted floors that allow for temporary separation of the feet from the litter could lead to improvements in foot pad health which could better enable the realization of species-specific behaviours and activities in littered areas.
Fine particulate matter associated mortality burden of lung cancer in Hebei Province, China

The association between fine particulate matter (PM2.5) and lung cancer (LC) mortality in China is limited. The Beijing‐Tianjin‐Hebei region is infamous for serious air pollution. Seven of the top 10 cities with the worst air quality are located in Hebei Province. Thus, we explored the effect of 10 years of PM2.5 on the LC mortality rate in Hebei Province.
Dominating the news: government officials in front-page news coverage of policy issues in the United States and Korea

Abstract What determines which political actors dominate a country’s news? Understanding the forces that shape political actors’ news coverage matters, because these actors can influence which problems and alternatives receive a nation’s public and policy attention. Across free-press nations, the degree of media attention actors receive is rarely proportional to their degree of participation in the policymaking process. Yet, the nature of this “mis”-representation varies by country. We argue that journalistic operating procedures – namely, journalists’ incentive-driven relationships with government officials – help explain cross-national variance in actors’ media representation relative to policymaking participation. We examine two free-press countries with dramatically different journalistic procedures: United States and Korea. For each, we compare actors’ policymaking participation to news coverage (using all 2008 New York Times and Hankyoreh Daily front-page stories). Although exhibiting greater general discrepancy between actors’ policymaking and media representation, diverse actors are over-represented in United States news; in Korea, governmental actors are dominant.
Open Science and the Academy: A Theoretical Discussion

The Open Science movement is gaining traction since the G8 Science Ministers made a joint statement in 2013 on open scientific research data and increasing access to the peerreviewed published results of scientific research. Major policy developments can be seen in funding agencies mandating open access to scientific results. However, the idea of Open Science represents an alternate approach to the scientific process enabled by digital technologies encompassing the entire research cycle, including how researchers are being evaluated and rewarded. Still, even though the idea of Open Science is envisioned as a systematic change in the way science is performed, the scientific communities remain largely ignorant on this issue.This paper presents a theoretical discussion on how academics might adopt the idea of Open Science by scrutinizing the background and evolution of this policy agenda and the issues arising from it, and by analyzing academias perception of and behavior toward Open Science. The misalignment of Open Science purposes and the researchers value is pointed out as the major impediment to realization of Open Science concept.
MicroRNA-124 Functions as a Tumor Suppressor by Regulating CDH2 and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer

Background/Aims: Abnormal expression of microRNA-124 (miR-124) was found in non-small cell lung cancer (NSCLC). However, the association between miR-124 and CDH2 has not been reported yet. This study aims to reveal the inhibiting effects of miR-124 on the expression of CDH2 in NSCLC. Methods: Quantitative real-time polymerase chain reaction was used to evaluate the expression of miR-124 and CDH2 in NSCLC tissues. Cell viability, apoptosis and invasion assays were carried out in NSCLC cell lines after transfection. The regulation mechanism was confirmed by luciferase report assay and western blot (WB). Results: Significantly decreased expression of miR-124 was found in NSCLC specimens and cell lines. Overexpression of miR-124 apparently suppressed the proliferation and invasion of NSCLC cell lines in vitro. Luciferase report assay and WB revealed that CDH2 was a target gene of miR-124. Furthermore, results of WB showed that epithelial-mesenchymal transition (EMT) could be inhibited by up-regulation of miR-124. Conclusions: Taken together, our findings present the first evidence that miR-124 could suppress the expression of CDH2 and regulate EMT, which might lead to a potential therapeutic strategy focusing on miR-124 and CDH2 for human lung cancer.
Actions Speak Louder than Words: How Do Special Education Administrators Prevent and Resolve Conflict with Families?

Conflict between parents of children with disabilities and school district members has been an ongoing issue for decades. Special education administrators are often designated to address conflict with the intent to find an amicable resolution. Otherwise, conflict can lead to due process hearings that move valuable time and money away from general district funds. Understanding how administrators informally address such conflict can guide leaders as they promote collaboration between the home and school. This paper presents a qualitative interview study of special education directors’ experiences with conflict prevention and resolution. Seven key action-based strategies that prevent and resolve conflict with families were identified: establish communication, provide parent support, level the playing field, intervene at the lowest level possible, maintain the focus on the child, find a middle ground, and understand perspectives. Each of these themes is
Employment: A Study of Urban Youth in Egypt

Informal employment is a reality for roughly two-thirds of economically active youth in urban Egypt, and it has been argued to be correlated with poverty, poor working conditions, and few opportunities for advancement. This essay analyzes whether informal employment rewards job qualification measures, using survey data from 2006 and a Blinder-Oaxaca wage decomposition. After creating a taxonomy of formal, para-formal, and informal modes of qualification, it is shown that formal public and formal private jobs tend to reward those with formal qualifications, while informal employment tends to reward informal qualification mechanisms. The notion that informal employment does not reward qualification is disputed. Furthermore, there are large wage premia based on formality of employment, region, and gender. The results can be explained by analyzing the formality decision and the qualification decisions of youth. This suggests an alterative explanation for “dualistic” outcomes in youth labor markets.
Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells

NRF2 (NFE2L2) is one of the main regulators of the antioxidant response of the cell. Here we show that in cancer cells NRF2 targets are selectively upregulated or repressed through a mutant p53-dependent mechanism. Mechanistically, mutant p53 interacts with NRF2, increases its nuclear presence and resides with NRF2 on selected ARE containing gene promoters activating the transcription of a specific set of genes while leading to the transcriptional repression of others. We show that thioredoxin (TXN) is a mutant p53-activated NRF2 target with pro-survival and pro-migratory functions in breast cancer cells under oxidative stress, while heme oxygenase 1 (HMOX1) is a mutant p53-repressed target displaying opposite effects. A gene signature of NRF2 targets activated by mutant p53 shows a significant association with bad overall prognosis and with mutant p53 status in breast cancer patients. Concomitant inhibition of thioredoxin system with Auranofin and of mutant p53 with APR-246 synergizes in killing cancer cells expressing p53 gain-of-function mutants.
Soluble Neuregulin1 Down-Regulates Myelination Genes in Schwann Cells

Peripheral nerves are characterised by the ability to regenerate after injury. Schwann cell activity is fundamental for all steps of peripheral nerve regeneration: immediately after injury they de-differentiate, remove myelin debris, proliferate and repopulate the injured nerve. Soluble Neuregulin1 (NRG1) is a growth factor that is strongly up-regulated and released by Schwann cells immediately after nerve injury. To identify the genes regulated in Schwann cells by soluble NRG1, we performed deep RNA sequencing to generate a transcriptome database and identify all the genes regulated following 6 h stimulation of primary adult rat Schwann cells with soluble recombinant NRG1. Interestingly, the gene ontology analysis of the transcriptome reveals that NRG1 regulates genes belonging to categories that are regulated in the peripheral nerve immediately after an injury. In particular, NRG1 strongly inhibits the expression of genes involved in myelination and in glial cell differentiation, suggesting that NRG1 might be involved in the de-differentiation (or “trans-differentiation”) process of Schwann cells from a myelinating to a repair phenotype. Moreover, NRG1 inhibits genes involved in the apoptotic process, and up-regulates genes positively regulating the ribosomal RNA processing, thus suggesting that NRG1 might promote cell survival and stimulate new protein expression. This in vitro transcriptome analysis demonstrates that in Schwann cells NRG1 drives the expression of several genes which partially overlap with genes regulated in vivo after peripheral nerve injury, underlying the pivotal role of NRG1 in the first steps of the nerve regeneration process.
Did the Model Understand the Question?

We analyze state-of-the-art deep learning models for three tasks: question answering on (1) images, (2) tables, and (3) passages of text. Using the notion of “attribution” (word importance), we find that these deep networks often ignore important question terms. Leveraging such behavior, we perturb questions to craft a variety of adversarial examples. Our strongest attacks drop the accuracy of a visual question answering model from 61.1% to 19%, and that of a tabular question answering model from 33.5% to 3.3%. Additionally, we show how attributions can strengthen attacks proposed by Jia and Liang (2017) on paragraph comprehension models. Our results demonstrate that attributions can augment standard measures of accuracy and empower investigation of model performance. When a model is accurate but for the wrong reasons, attributions can surface erroneous logic in the model that indicates inadequacies in the test data.
PENGUKURAN PEMILIHAN SAHAM DAN PENETAPAN WAKTU MENGGUNAKAN MODEL TREYNOR-MAZUY PADA REKSADANA SYARIAH DI INDONESIA

This research aims is to evaluate performance of sharia mutual fund in Indonesia by assessing investment manager’s ability and by inserting public information for considering investment in capital market. This research uses Treynor-Mazuy’s model that is in turn developed by Ferson-Walther’s model for conditional version. The statistic method to test on this study are Multiple Regression and Autoregressive Conditional Heteroscedasticity (ARCH). Based on examination result of two sharia equity mutual fund data shows that stock selection ability of investment manager give a positive contribution to the fund returns, while market timing ability give a negative contribution to fund returns. , and public information that is relied on in making decision for investment of Sharia capital market is information about changes of exchange rate. DOI: 10.15408 /etk.v12i1. 1898
Delayed Diagnosis and Complications of Predominantly Antibody Deficiencies in a Cohort of Australian Adults

Background Predominantly antibody deficiencies (PADs) are the most common type of primary immunodeficiency in adults. PADs frequently pass undetected leading to delayed diagnosis, delayed treatment, and the potential for end-organ damage including bronchiectasis. In addition, PADs are frequently accompanied by comorbid autoimmune disease, and an increased risk of malignancy. Objectives To characterize the diagnostic and clinical features of adult PAD patients in Victoria, Australia. Methods We identified adult patients receiving, or having previously received immunoglobulin replacement therapy for a PAD at four hospitals in metropolitan Melbourne, and retrospectively characterized their clinical and diagnostic features. Results 179 patients from The Royal Melbourne, Alfred and Austin Hospitals, and Monash Medical Centre were included in the study with a median age of 49.7 years (range: 16–87 years), of whom 98 (54.7%) were female. The majority of patients (116; 64.8%) met diagnostic criteria for common variable immunodeficiency (CVID), and 21 (11.7%) were diagnosed with X-linked agammaglobulinemia (XLA). Unclassified hypogammaglobulinemia (HGG) was described in 22 patients (12.3%), IgG subclass deficiency (IGSCD) in 12 (6.7%), and specific antibody deficiency (SpAD) in 4 individuals (2.2%). The remaining four patients had a diagnosis of Good syndrome (thymoma with immunodeficiency). There was no significant difference between the age at diagnosis of the disorders, with the exception of XLA, with a median age at diagnosis of less than 1 year. The median age of reported symptom onset was 20 years for those with a diagnosis of CVID, with a median age at diagnosis of 35 years. CVID patients experienced significantly more non-infectious complications, such as autoimmune cytopenias and lymphoproliferative disease, than the other antibody deficiency disorders. The presence of non-infectious complications was associated with significantly reduced survival in the cohort. Conclusion Our data are largely consistent with the experience of other centers internationally, with clear areas for improvement, including reducing diagnostic delay for patients with PADs. It is likely that these challenges will be in part overcome by continued advances in implementation of genomic sequencing for diagnosis of PADs, and with that opportunities for targeted treatment of non-infectious complications.
Image Ordinal Classification and Understanding: Grid Dropout with Masking Label

Image ordinal classification refers to predicting a discrete target value which carries ordering correlation among image categories. The limited size of labeled ordinal data renders modern deep learning approaches easy to overfit. To tackle this issue, neuron dropout and data augmentation were proposed which, however, still suffer from over-parameterization and breaking spatial structure, respectively. To address the issues, we first propose a grid dropout method that randomly dropout/blackout some areas of the training image. Then we combine the objective of predicting the blackout patches with classification to take advantage of the spatial information. Finally we demonstrate the effectiveness of both approaches by visualizing the Class Activation Map (CAM) and discover that grid dropout is more aware of the whole facial areas and more robust than neuron dropout for small training dataset. Experiments are conducted on a challenging age estimation dataset-Adience dataset with very competitive results compared with state-of-the-art methods.
Evaluation of prototype of improved electron collimation system for Elekta linear accelerators

Abstract Purpose This study evaluated a new electron collimation system design for Elekta 6–20 MeV beams, which should reduce applicator weights by 25%–30%. Such reductions, as great as 3.9 kg for the largest applicator, should result in considerably easier handling by members of the radiotherapy team. Methods Prototype 10 × 10 and 20 × 20‐cm2 applicators, used to measure weight, in‐field flatness, and out‐of‐field leakage dose, were constructed according to the previously published design with two minor modifications: (a) rather than tungsten, lead was used for trimmer material; and (b) continuous trimmer outer‐edge bevel was approximated by three steps. Because of lead plate softness, a 0.32‐cm aluminum plate replaced the equivalent lead thickness on the trimmer's downstream surface for structural support. Models of all applicators (6 × 6–25 × 25 cm2) with these modifications were inserted into a Monte Carlo (MC) model for dose calculations using 7, 13, and 20 MeV beams. Planar dose distributions were measured and calculated at 1‐ and 2‐cm water depths to evaluate in‐field beam flatness and out‐of‐field leakage dose. Results Prototype 10 × 10 and 20 × 20‐cm2 applicator measurements agreed with calculated weights, in‐field flatness, and out‐of‐field leakage doses for 7, 13, and 20 MeV beams. Also, MC dose calculations showed that all applicators (6 × 6–25 × 25 cm2) and 7, 13, and 20 MeV beams met our stringent in‐field flatness specifications (±3% major axes; ±4% diagonals) and IEC out‐of‐field leakage dose specifications. Conclusions Our results validated the new electron collimating system design for Elekta 6–20 MeV electron beams, which could serve as basis for a new clinical electron collimating system with significantly reduced applicator weights.
IPO Flotation Costs in Bangladesh During 1983-2006

Research on flotation costs in developed markets is quite handsome in number to develop the knowledge. This paper focuses to add new knowledge about the flotation cost of a developing country like Bangladesh. 254 IPO data have been included in this study during the period 1983-2006. We found an average flotation of 5.44 per cent during this period. However, the average flotation cost is 4.64 per cent during the last five years; and 4.79 per cent during the last ten years. This study reveals that there is economies of scale in mid-size IPOs, U-shaped pattern in large IPOs, and specific pattern in small IPOs. We identified good performing sectors in the capital market have lower flotation costs. We had also developed a flotation cost equation by accommodating current variables of flotation present in Bangladesh.