Miracle-dz/UniFAR-FTUs huggingface dataset:
Poor response inhibition as a predictor of problem drinking and illicit drug use in adolescents at risk for alcoholism and other substance use disorders.

OBJECTIVE To evaluate the predictive power of executive functions, in particular, response inhibition, in relation to alcohol-related problems and illicit drug use in adolescence. METHOD A total of 498 children from 275 families from a longitudinal high-risk study completed executive function measures in early and late adolescence and lifetime drinking and drug-related ratings at multiple time points including late adolescence (ages 15-17). Multi-informant measures of attention-deficit/hyperactivity disorder and conduct disorder were obtained in early childhood (ages 3-5), middle childhood, and adolescence. RESULTS In multilevel models, poor response inhibition predicted aggregate alcohol-related problems, the number of illicit drugs used, and comorbid alcohol and drug use (but not the number of drug-related problems), independently of IQ, parental alcoholism and antisocial personality disorder, child attention-deficit/hyperactivity disorder and conduct symptoms, or age. Multivariate models explained 8% to 20% of residual variance in outcome scores. The incremental predictive power of response inhibition was modest, explaining about 1% of the variance in most outcomes, but more than 9% of the residual variance in problem outcomes within the highest risk families. Other measured executive functions did not independently predict substance use onset. CONCLUSION Models of alcoholism and other drug risks that invoke executive functions may benefit from specifying response inhibition as an incremental component.
Female CEOs, Returns and Risk in Spanish Publishing Firms

This study examines the influence of CEO gender on returns and risk for a sample of 2,157 Spanish publishing firms in 2013. The publishing sector is relevant in Spain, in terms of output, because of its positive contribution to the cultural sector's trade balance and also because it plays a key strategic role in a knowledge-based society. Previous evidence suggests that women in senior management position affect the performance of firms and also the level of risk that the firm is exposed to. Our results show that publishing companies whose CEO is female have greater returns. This result is observed when both the return on assets and the return on equity are considered as the dependent variable. When we focus on risk, we find a lower debt level and lower financial leverage when the CEO is a woman.
Randomized placebo-controlled study of lovastatin in children with neurofibromatosis type 1

Objective: To assess the efficacy of lovastatin on visuospatial learning and attention for treating cognitive and behavioral deficits in children with neurofibromatosis type 1 (NF1). Methods: A multicenter, international, randomized, double-blind, placebo-controlled trial was conducted between July 2009 and May 2014 as part of the NF Clinical Trials Consortium. Children with NF1 aged 8–15 years were screened for visuospatial learning or attention deficits (n = 272); 146 children demonstrated deficits at baseline and were randomly assigned to lovastatin (n = 74; 40 mg/d) or placebo (n = 70). Treatment was administered once daily for 16 weeks. Primary outcomes were total errors on the Cambridge Neuropsychological Test Automated Battery Paired Associate Learning task (visuospatial learning) and the Score subtest from the Test of Everyday Attention for Children (sustained attention). Secondary outcomes measured executive function, attention, visuospatial skills, behavior, and quality of life. Primary analyses were performed on the intention-to-treat population. Results: Lovastatin had no significant effect on primary outcomes after 16 weeks of treatment: visuospatial learning (Cohen d = −0.15, 95% confidence interval −0.47 to 0.18) or sustained attention (Cohen d = 0.19, 95% confidence interval −0.14 to 0.53). Lovastatin was well tolerated, with no increase in reported adverse events compared to placebo. Conclusions: Lovastatin administered once daily for 16 weeks did not improve visuospatial learning or attention in children with NF1 and is not recommended for amelioration of cognitive deficits in this population. ClinicalTrials.gov identifier: This study was registered at ClinicalTrials.gov (NCT00853580) and Australian New Zealand Clinical Trials Registry (ACTRN12607000560493). Classification of evidence: This study provides Class I evidence that for children with NF1, lovastatin does not improve visuospatial learning or attention deficits.
Survey of patient knowledge related to acetaminophen recognition, dosing, and toxicity.

OBJECTIVE To assess patient knowledge regarding acetaminophen dosing, toxicity, and recognition of acetaminophen-containing products. DESIGN Descriptive, nonexperimental, cross-sectional study. SETTING Alabama, January 2007 to February 2008. PATIENTS 284 patients at four outpatient medical facilities. INTERVENTION 12-item investigator-administered questionnaire. MAIN OUTCOME MEASURES Degree of patient knowledge regarding acetaminophen safety, dosing recommendations, toxicity, alternative names and abbreviations, and products. RESULTS Two-thirds of the 284 patients completing the survey reported current or recent use of pain, cold, or allergy medication. Of these, 25% reported knowing the active ingredient. Of patients, 46% and 13% knew that "acetaminophen" and "APAP," respectively, were synonymous with "Tylenol. " Several patients (12%) believed that ingesting a harmful amount of acetaminophen was difficult or impossible. One-third of patients correctly identified the maximum daily dose, 10% reported a dose greater than 4 g, 25% were unsure of the dose, and 7% were unsure whether a maximum dose existed. One-half recognized liver damage as the primary toxicity. Results were similar between acetaminophen users and nonusers. CONCLUSION Deficiencies were found in patient knowledge regarding acetaminophen recognition, dosing, and potential for toxicity. The development of effective educational initiatives is warranted to ensure patient awareness and limit the potential for acetaminophen overdose.
A quantitative analysis of antigen-triggered lymphokine production by activated T cells.

We have developed a theoretical model to describe the triggering of lymphokine release from antigen-specific, activated T (T') cells, and we have used this model to define parameters that regulate this interaction. Under assay conditions of T' cell excess, the efficiency of triggering is a function of the target cell type. When various H-2k-bearing target cells were used to trigger B10.AQR T' cells activated against B10.A cells (anti-Kk), a hierarchy of triggering efficiency was observed with B10.A Con A blasts greater than R1.1 tumor cells greater than B10.A spleen cells greater than B10.A lymph node cells. There was a 10-fold difference in triggering efficiency between Con A blasts and lymph node cells. A similar pattern of reactivity was observed for various H-2d-bearing target cells used to trigger CBA T' cells specific for BALB/c antigens (anti-H-2d). Under assay conditions of T' cell excess, the order of reaction, i.e., the number of target cells per T' cell required to trigger lymphokine release, remained constant for the different target cell types. However, the order of reaction can vary with conditions of T cell activation. CBA T' cells activated against BALB/c spleen cells exhibited pseudo-first-order reactivity when triggered for lymphokine release with P815 target cells, whereas CBA T' cells activated against UV-irradiated P815 cells exhibited pseudo-second-order reactivity when triggered by the same tumor cells. Thus, T cells with the same apparent specificity can be qualitatively different in their reactivity with antigen. Under assay conditions of target cell excess, our analysis indicated that no T-T interaction was involved in the triggering reaction. Finally, our analysis was applied to study the nature of cross-reactivity. The results indicated that the triggering of lymphokine elicited by a cross-reactive antigen was due to the reactivity of a discrete subset of T' cells.
Inequality in Germany: Decrease in gap for gross hourly wages since 2014, but monthly and annual wages remain on plateau

Despite the booming German labor market, wage inequality is still a relevant issue. In the present study, the authors report on the changes in wages and their distribution between 1992 and 2016. In addition to real contractual gross hourly wages, we closely examined gross monthly and annual wages. Based on Socio-Economic Panel (SOEP) data, the results show that wage inequality rose significantly between 1992 and 2005, in particular with respect to monthly and annual wages. Since then inequality in monthly and annual wages has plateaued at its 2005 level. Inequality in hourly wages has decreased only since 2014, and between 2013 and 2016, average real gross hourly wages rose by five percent after a longer phase of stagnation. For the lowest ten percent of the population, they rose by 13 percent—a rate related to the implementation of sector-specific wages and the statutory minimum wage. However, these minimum wages obviously did not affect monthly and annual wages as anticipated.
What is Private Land Stewardship? Lessons from Agricultural Opinion Leaders in North Carolina

The development of private land is a significant conservation concern globally. To conserve the ecosystem services associated with private lands, conservationists must understand landowner conceptions of stewardship and its role in decisions about land and natural resources. We began addressing this need with a survey of North Carolina Farm Bureau county advisory board members in North Carolina (n = 735). Nearly all respondents self-identified as stewards of the land (97%). More respondents indicated their stewardship responsibility was owed to future generations (87%) and family (77%), rather than to the community (41%) or society (26%). Respondents associated stewardship more with using natural resources wisely (78%) than leaving natural resources untouched (31%). Plans to bequeath land to relatives, the importance of soil conservation, and past participation in conservation programs were the most consistent predictors of how respondents viewed stewardship. Our results suggest that stewardship may be more effective when framed more as a benefit to family and future generations than to society and the community. Similarly, stewardship may be more effective for achieving conservation as opposed to the preservation of natural resources.
Two novel GALNT3 mutations in familial tumoral calcinosis

Familial tumoral calcinosis (TC) is characterized by elevated serum phosphate concentrations, normal or elevated 1,25(OH)2 vitamin D, as well as periarticular and vascular calcifications. Recessive mutations in the mucin‐like glycosyltransferase GalNAc transferase‐3 (GALNT3) and the phosphaturic hormone fibroblast growth factor‐23 (FGF23) have been shown to result in TC. In the present study, mutational analyses were performed on two patients with TC to determine the molecular basis of their diseases. Analysis of the first patient revealed a novel, homozygous base insertion (1102_1103insT) in GALNT3 exon 5 that results in a frameshift and premature stop codon (E375X). The second patient had a novel homozygous transition (1460 g>a) in GALNT3 exon 7, which caused a nonsense mutation (W487X). Both mutations are predicted to markedly truncate the mature GALNT3 protein product. Although the patients carry GALNT3 mutations, these individuals presented with low‐normal serum concentrations of intact biologically active FGF23 and high levels of C‐terminal FGF23. In order to discern a possible relationship between GALNT3 and FGF23 in TC, a comprehensive assessment of the reported TC mutations was also performed. In summary, we have detected novel GALNT3 mutations that result in familial TC, and show that disturbed serum FGF23 concentrations are present in our TC cases as well as in previously reported cases. These studies expand our current genetic understanding of familial TC, and support a pathophysiological association between GALNT3 and FGF23. © 2007 Wiley‐Liss, Inc.
Apical Extrusion of Intracanal Bacteria following use of Two Engine-driven Instrumentation Techniques: An in vitro Study.

AIM The aim of the present study was to compare in vitro the amount of debris extruded apically from extracted teeth, using Twisted files and ProTaper rotary during two different instrumentation systems. MATERIALS AND METHODS Forty-five human single-rooted mandibular premolar teeth were randomly divided into three groups and contaminated with Enterococcus faecalis. The teeth in experimental groups were instrumented until reaching the working length with ProTaper rotary instruments and Twisted files with XSmart and XSmart Dual groups. Debris extruded from the apical foramen was collected into glass vials and the amount of bacteria was calculated. The data obtained were analyzed using Kruskal-Wallis one-way analysis of variance and Mann-Whitney U tests, with p = 0.05 as the level for statistical significance. RESULTS The XSmart Dual group extruded comparatively lesser bacteria compared to the XSmart group. Lesser amount of bacterial extrusion was seen when Twisted files were used compared to the ProTaper files (p < 0.05). CONCLUSION Under the circumstances of this in vitro study, it can be concluded that all instrumentation techniques produced measurable apical extrusion of debris. So, it is upon the practitioner to decide which system best fits their individual needs and their level of skill and experience that will provide the best possible endodontic care for our patients. CLINICAL SIGNIFICANCE The newer instrument designs, including noncutting tips, different cross sections, radial lands, and variable tapers, are better for the clinicians to improve working safety, to reduce the working time, and to create a greater flare within the preparations.
Functional barriers to the adoption of electronic banking: The moderating effect of gender

The adoption of electronic banking in Spain is lower compared to other countries. This study analyzes the barriers that prevent its adoption, with the conceptual framework of the theory of resistance to innovation. In addition, it analyzes the moderating effect of gender on these barriers. Using structural equations, through PLS and multi-group analysis, the results confirm consumer resistance to electronic banking adoption by functional barriers. It highlights the importance of the value barrier, being this aspect of particular relevance for men, while women are more affected by the complexity in the use of electronic banking. These results have implications for management in overcoming non-adopters' resistance to the innovation.
Negative Bias-Induced Threshold Voltage Instability in GaN-on-Si Power HEMTs

This letter reports an in-depth study of the negative threshold voltage instability in GaN-on-Si metal-insulator-semiconductor high electron mobility transistors with partially recessed AlGaN. Based on a set of stress/recovery experiments carried out at several temperatures, we demonstrate that: 1) operation at high temperatures and negative gate bias (-10 V) may induce a significant negative threshold voltage shift, that is well correlated to a decrease in on-resistance; 2) this process has time constants in the range between 10-100 s, and is accelerated by temperature, with activation energy equal to 0.37 eV; and 3) the shift in threshold voltage is recoverable, with logarithmic kinetics. The negative shift in threshold voltage is ascribed to the depletion of trap states located at the SiN/AlGaN interface and/or in the gate insulator.
“Their Days are Spent in Gambling and Loafing, Pimping for Prostitutes, and Picking Pockets”: Male Juvenile Delinquents on Lagos Island, 1920s-1960s

In recent times, Lagos Island has been hit by a cyclical crescendo of juvenile crime perpetrated by “Area Boys,” jobless youths who deal in robbery, extortion, and blackmail. Such deviant behavior has historical roots back to colonial times, when youths labeled “alkali boys,” “boma boys,” and “cowboys” roamed the heart of the capital of Britain’s colony of Nigeria between the 1920s and 1960s. Examining the various types of juvenile delinquents on Lagos Island, this article explores the urban experience of criminally minded youths through explorations of street-life, vagrancy, criminality, and public reactions.
The Carrot or the Stick? Investigating the Functional Meaning of Cash Rewards and Their Motivational Power According to Self-Determination Theory

As much debate exists concerning the beneficial effect of using financial incentives to motivate employees in the scientific and practitioner literature, the current research explored employees’ perceptions of the cash rewards they receive at work to better understand their motivational impact. A model based on self-determination theory and its postulates concerning the functional significance of rewards was tested in two studies, one with Canadians and another with international workers. Results from path analysis indicate that through their impact on employees’ psychological needs, cash rewards perceived as informational lead to healthier forms of motivation, greater psychological health, and better overall work intentions than cash rewards perceived as controlling. These findings suggest that compensation plans must be carefully studied, designed, and implemented with the workforce to avoid overemphasizing the reward contingencies in employees’ eyes, having a deleterious impact on their motivation, and giving rise to unwarranted consequences on their psychological health and work behaviors.
Effects of long workhours on life-style, stress and quality of life among intermediate Japanese managers.

OBJECTIVES In accordance with international coordination of labor conditions a Japanese campaign advocating less work finally got under way recently in the form of work-reducing policies of the government to prevent occupational and stress-related diseases. However, long workhours among intermediate managers, who are key persons in most organizations in Japanese industry, are still considered to be prevalent. This study was conducted to examine the workhours of intermediate managers and clarify the effects of long workhours on the life-style, subjective stress, and subjective quality of life among them. METHODS Questionnaires were administered concerning workhours, life-styles, subjective stress, and subjective quality of life to 3870 heads of a division or a section and 2666 foremen in 110 firms in Japan. RESULTS The prevalence of > or = 10 workhours was 69.7% for the divisional or sectional heads and 53.2% for the foremen. Long workhours had significant effects on the managers' life-style, such as sleeping pattern and regularity of daily life and meals. The divisional or sectional managers with long workhours perceived higher stress [odds ratio (OR) 2.51, 95% confidence interval (95% CI) 2.17-2.90] and lower quality of life (OR 1.17, 95% CI 1.02-1.36) than those who worked relatively short hours. The foremen with long workhours perceived higher stress (OR 2.35, 95% CI 2.01-2.75) and lower quality of life (OR 1.26, 95% CI 1.08-1.46) than those who worked relatively short hours. CONCLUSIONS Long workhours may be associated with poorer life-style, higher stress, and lower quality of life among managers at the intermediate level.
Re‐Examining the Role of Structural Change and Nonlinearities in a Phillips Curve Model for South Africa

Although studies generally find evidence of a Phillips curve‐type relationship in South Africa, uncertainty remains about the relevance of the model over a relatively long sample period, and whether conventional output gap measures are suitable proxies for demand pressure. This paper reviews research which shows that the Phillips curve model prevails over an extended sample, provided that the benchmark specifications include major structural changes in the balance‐of‐payments and labour market, and account for shifts in the root causes of inflation. When this is done, a linear specification with an output gap in levels correctly predicts the non‐trended inflation pattern over the period 1971(Q1)–1984(Q4), whereas a piecewise concave curve with an output gap in growth rates accurately forecasts the decelerating inflation pattern during 1986(Q1)–2001(Q2). A novel feature of the concave model is that it remains statistically robust and structurally stable when it is estimated until 2015(Q4). The concave model imparts a disinflationary bias, which suggests that monetary policy should be more expansionary during downswing phases of the business cycle and neutral during upswing phases. The analysis also considers how the shape of the Phillips curve might change if the balance‐of‐payments constraint on demand is relaxed in a significant way.
Enhancing the Immunogenicity of Exogenous Hepatitis B Surface Antigen-Based Vaccines for MHC-I-Restricted T Cells

Abstract Vaccination with either exogenous hepatitis B surface antigen (HBsAg) lipoprotein particles without adjuvants, or plasmid DNA encoding secreted small HBsAg stimulate long-lasting, potent antibody responses in H-2d (BALB/c) and C57Bl/6 (H-2b) mice. Vaccination with exogenous HBsAg primes MHC-I restricted cytotoxic T lymphocyte (CTL) responses to HBsAg in H-2d but not H-2b mice, while DNA vaccination primes HBsAg-specific CTL responses in both mouse strains. We defined vaccination strategies that could elicit CTL responses to exogenous HBsAg in ‘low responder’ C57Bl/6 mice. We found that the bacterial plasmid DNA itself, synthetic oligodeoxynucleotides containing immunostimulating sequences, or recombinant Th1 cytokines (IL12, IFNγ) efficiently support priming of CTL responses to exogenous HBsAg in ‘low responder’ H-2b mice, but have only minor effects on CTL priming in ‘high responder’ H-2d mice in the high dose range tested. These molecularly well defined adjuvants can thus efficiently support priming of anti-viral T cell responses under ‘low responder’ conditions.
Motor, visual and egocentric transformations in children with Developmental Coordination Disorder.

AIM This study aimed to test the internal modelling deficit (IMD) hypothesis using the mental rotation paradigm. BACKGROUND According to the IMD hypothesis, children with Developmental Coordination Disorder (DCD) have an impaired ability to internally represent action. Thirty-six children (18 DCD) completed four tasks: two versions of a single-hand rotation task (with and without explicit imagery instructions), a whole-body imagery task and an alphanumeric rotation task. RESULTS There was partial support for the hypothesis that children with DCD would display an atypical pattern of performance on the hand rotation task, requiring implicit use of motor imagery. Overall, there were no significant differences between the DCD and control groups when the hand task was completed without explicit instructions, on either response time or accuracy. However, when imagery instructions were introduced, the controls were significantly more accurate than the DCD group, indicating that children with DCD were unable to benefit from explicit cuing. As predicted, the controls were also significantly more accurate than the DCD group on the whole-body task, with the accuracy of the DCD group barely rising above chance. Finally, and as expected, there was no difference between the groups on the alphanumeric task, a measure of visual (or object-related) imagery. CONCLUSIONS The inability of the DCD group to utilize specific motor imagery instructions and to perform egocentric transformations lends some support to the IMD hypothesis. Future work needs to address the question of whether the IMD itself is subgroup-specific.