Miracle-dz/UniFAR-FTUs huggingface dataset:
Benefits and risks of the treatment with fibrates––a comprehensive summary

ABSTRACT Introduction: The need to reduce residual cardiovascular risk led to the development of novel therapeutic strategies to improve patients’ outcomes. The residual risk in people with atherogenic dyslipidemia, despite LDL reduction obtained mainly by statins, remains high. Fibrates in those patients lead to significant clinical improvements. Those include reduction in the progression of atherosclerosis, which translates into decrease in cardiovascular events and improvements in microvascular diabetic complications. Furthermore, there are other clinical and biochemical benefits connected with fibrate therapy (e.g. improved insulin sensitivity). Nevertheless, similar to all effective therapeutic modalities, fibrates are associated with unfavorable effects that may lead to complications or treatment discontinuation. Here, we provide up-to-date review of benefits and potential risks associated with the therapy with fibrates. Area covered: A review of available data from clinical trials, meta-analyses and case-reports on the efficacy of fibrate treatment was performed. A specific attention was given to clinical and biochemical benefits as well as adverse events that were reported. Expert commentary: Fibrates are performing well as drugs that reduce residual risk in patients with atherogenic dyslipidemia and hypertriglyceridemia. The adverse events rate is not negligible, but definitely manageable by selection of proper target population and supervision of treated patients.
DRL-Scheduling: An Intelligent QoS-Aware Job Scheduling Framework for Applications in Clouds

As an increasing number of traditional applications migrated to the cloud, achieving resource management and performance optimization in such a dynamic and uncertain environment becomes a big challenge for cloud-based application providers. In particular, job scheduling is a non-trivial task, which is responsible for allocating massive job requests submitted by users to the most suitable resources and satisfying user QoS requirements as much as possible. Inspired by recent success of using deep reinforcement learning techniques to solve AI control problems, in this paper, we propose an intelligent QoS-aware job scheduling framework for application providers. A deep reinforcement learning-based job scheduler is the key component of the framework. It is able to learn to make appropriate online job-to-VM decisions for continuous job requests directly from its experiences without any prior knowledge. Experimental results using synthetic workloads and real-world NASA workload traces show that compared with other baseline solutions, our proposed job scheduling approach can efficiently reduce average job response time (e.g., reduced by 40.4% compared with the best baseline for NASA traces), guarantee the QoS at a high level (e.g., job success rate is higher than 93% for all simulated changing workload scenarios), and adapt to different workload conditions.
The UCR time series archive

The UCR time series archive–introduced in 2002, has become an important resource in the time series data mining community, with at least one thousand published papers making use of at least one data set from the archive. The original incarnation of the archive had sixteen data sets but since that time, it has gone through periodic expansions. The last expansion took place in the summer of 2015 when the archive grew from 45 to 85 data sets. This paper introduces and will focus on the new data expansion from 85 to 128 data sets. Beyond expanding this valuable resource, this paper offers pragmatic advice to anyone who may wish to evaluate a new algorithm on the archive. Finally, this paper makes a novel and yet actionable claim: of the hundreds of papers that show an improvement over the standard baseline ( 1-nearest neighbor classification ), a fraction might be mis-attributing the reasons for their improvement. Moreover, the improvements claimed by these papers might have been achievable with a much simpler modification, requiring just a few lines of code.
Acute reduction in posterior cerebral blood flow following isometric handgrip exercise is augmented by lower body negative pressure

The mechanism(s) for the increased occurrence of a grayout or blackout, syncope, immediately after heavy resistance exercise are unclear. It is well‐known that orthostatic stress increases the occurrence of postexercise syncope. In addition, previous findings have suggested that hypo‐perfusion, especially in the posterior cerebral circulation rather than anterior cerebral circulation, may be associated with the occurrence of syncope. Herein, we hypothesized that the postexercise decrease in posterior, but not anterior, cerebral blood flow (CBF) would be greater during orthostatic stress. Nine healthy subjects performed 3‐min isometric handgrip (HG) at 30% maximum voluntary contraction without (CONTROL) and during lower body negative pressure (LBNP; −40 Torr) while vertebral artery (VA) blood flow, as an index of posterior CBF, and middle cerebral artery blood velocity (MCAv), as an index of anterior CBF, were measured. Immediately after HG (0 to 15 sec of recovery phase), mean arterial pressure decreased but there was no difference in this reduction between CONTROL and LBNP conditions (−15.4 ± 4.0% and −17.0 ± 6.2%, P = 0.42). Similarly, MCAv decreased following exercise and was unaffected by the application of LBNP (P = 0.22). In contrast, decreases in VA blood flow immediately following HG during LBNP were significantly greater compared to CONTROL condition (−24.2 ± 9.5% and ‐13.4 ± 6.6%, P = 0.005). These findings suggest that the decrease in posterior CBF immediately following exercise was augmented by LBNP, whereas anterior CBF appeared unaffected. Thus, the posterior cerebral circulation may be more sensitive to orthostatic stress during the postexercise period.
Placental Peripartum Pathologies in Women with Preeclampsia and Eclampsia

Objective To determine the pattern of pathological changes in placentas of preeclamptic/eclamptic parturients and its correlation with the clinical severity as well as the perinatal outcome. Methods A cross-sectional analytical study of placental pathologies in preeclamptic/eclamptic patients was performed in a blinded pattern and compared with matched normal controls. Data were analyzed using Epi-Info 2008 version 3.5. 1. Results Placental pathologies were evaluated in 61 preeclamptic/eclamptic patients and in 122 controls. Of the 61 placentas, 53 (4.7%) were of preeclampsia while 8 (0.71%) were of eclampsia. Of the preeclamptic group, 14 (23%) had mild preeclampsia while 39 (63.9%) had severe preeclampsia. Infarction, haematoma, and some histological changes increased with the severity of preeclampsia (p < 0.001). When comparing placentas in eclampsia, severe preeclampsia, mild preeclampsia, and normal controls, there was respective increase in the presence of any infarction (75%, 66.7%, 35.7% vs. 12.3%) or any haematoma (100%, 100%, 71.4% vs. 35.2%), decidual arteriopathy (87.5%, 76.9%, 64.3% vs. 35.2%), cytotrophoblastic proliferation (75%, 71.8%, 42.9% vs. 25.4%), and accelerated villous maturation (75%, 69.2%, 57.1% vs. 31.1%). There was no statistically significant difference in placental calcifications, stromal oedema, stromal fibrosis, and syncytial knots. Degree of placental infarction was correlated with the fetal birth weight. The fetal birth weight with placental involvement of >10% was significant (p=0.01). Conclusion In mild or severe preeclampsia/eclampsia, placentas had significant histological signs of ischaemia and degree of placental involvement by infarction is inversely proportional to fetal birth weight. While feto-placental ratio was higher with increased severity of the disease, the mean weight was less. This trial is registered with researchregistry3503.
Temperature Dependent Electrical Transport Properties of High Carrier Mobility Reduced Graphene Oxide Thin Film Devices

We report temperature dependent electrical transport properties of high mobility reduced graphene oxide (RGO) thin films fabricated by pulse laser deposition. The temperature dependent (5K–350K) four terminal electrical transport property measurements confirm variable range hopping and thermally activated transport mechanism of the charge carriers at low (5K–210K) and high temperature (210K–350K) regions, respectively. The calculated localization length, the density of states near the Fermi level (<inline-formula> <tex-math notation="LaTeX">$E_{F}$ </tex-math></inline-formula>), hopping energy, and Arrhenius energy gap provide useful information to explain the excellent electrical properties of the RGO films. Hall mobility measurement confirms <inline-formula> <tex-math notation="LaTeX">${p}$ </tex-math></inline-formula>-type characteristics of the thin films. The charge carrier Hall mobility can be engineered by tuning the growth parameters, and the measured maximum mobility was 1596 cm<sup>2</sup>v<sup>−1</sup>s<sup>−1</sup>. The optimization of the improved electrical property is well supported by structural properties such as the defect density, average size of sp<sup>2</sup> clusters and degree of reduction, which were investigated by Raman spectroscopy and X-ray diffraction analysis.
Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer

Background: Cetuximab has been regularly added to the treatments for metastatic colorectal cancer worldwide. However, due to its therapeutic insensitivity and underlying mechanisms being largely unknown, the clinical implementation of cetuximab in colorectal cancer remains limited. Methods: The gene expression profile GSE56386 was retrieved from the Gene Expression Omnibus database. Differentially expressed genes were identified between cetuximab-responsive patients and nonresponders, annotated by gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway analysis, and further analyzed by protein–protein interaction networks. The integrative prognostic analysis was based on The Cancer Genome Atlas and PrognoScan. Results: 1350 differentially expressed genes were identified with 298 upregulated and 1052 downregulated. Epidermis development, the cornified envelope, calcium ion binding, and amoebiasis were enriched in upregulated genes while digestion, the apical part of the cell, the 3′,5′-cyclic-adenosine monophosphate phosphodiesterase activity and pancreatic secretion were found enriched in downregulated genes. The top 10 hub genes were identified, including epithermal growth factor, G-protein subunit β 5, G-protein subunit γ 4, fibroblast growth factor 2, B-cell lymphoma protein 2, acetyl-coenzyme A carboxylase β, KIT proto-oncogene receptor tyrosine kinase, adenylate cyclase 4, neuropeptide Y, and neurotensin. The hub genes exhibited distinct correlations in cetuximab-treated and untreated genomic profiles (GSE56386, GSE5851 and GSE82236). The highest correlation was found between B-cell lymphoma protein 2 and acetyl-coenzyme A carboxylase β in GSE56386. The mRNA expression of hub genes was further validated in the genomic profile GSE65021. Furthermore, B-cell lymphoma protein 2 and acetyl-coenzyme A carboxylase β also exhibited highest degrees among the hub genes correlation networks based on The Cancer Genome Atlas. Both B-cell lymphoma and acetyl-coenzyme A carboxylase β were not independent prognostic factors for colorectal cancer in univariate and multivariate Cox analysis. However, integrative survival analysis indicated that B-cell lymphoma protein 2 was associated with favorable prognosis (hazard ratio = 0.62, 95% confidence interval, 0.30-0.95, P = .024). Discussion: This in silico analysis provided a feasible and reliable strategy for systematic exploration of insightful target genes, pathways and mechanisms underlying the cetuximab insensitivity in colorectal cancer. B-cell lymphoma protein 2 was associated with favorable prognosis.
Game-Theoretic Approach to Group Learning Enhancement Through Peer-to-Peer Explanation and Competition

Learners may not be motivated to actively participate in the stages of learning. This paper aims to motivate learners to get effectively involved in the learning process, i.e., they learn both directly from an instructor and by learning from and teaching each other in an interactive manner. Hence, we introduce a game with a purpose that motivates learners to become involved in the learning process to effectively improve their learning performance. In order to meet the mentioned objective, this paper proposes a game-theoretic approach based on explanation and competition, which uses competitive learning and explanatory techniques. In this game, the learners are encouraged to compete for more beneficial explanations of educational concepts. We also use rewards and punishments as a means of encouraging learners to provide efficient explanations. We then apply game theoretic concepts to analyze the defined parameters in the proposed game for a Nash equilibrium that leads learners to have stronger motivations for providing good explanations. The statistical analysis of experimental results using the Student’s t-test indicates that the proposed game drives the learners to participate actively in different learning stages and helps them to improve their knowledge more efficiently.
Application of Multiply Regression Linear Model and New Technology Method in Estimating Learning and Education of Students

The Linear multiple regression model is one of the prediction models whose parametric estimations could be achieved in different methods. With the advent of modern technologies and modern information technologies and its impact on various aspects of life, using it as a tool to facilitate learning in all the courses, and in particular mathematics, is inevitable. Meanwhile, the key role of the teacher in the teaching-learning process, the need for teachers to prepare teachers to face the diversity of existing technologies, to measure and identify efficient tools and apply them to teaching, undeniably undeniable. Which will be very complicated. In order to prepare for the teaching of mathematics, their teachers must have a profound and broad understanding of the subjects and mathematical subjects in order to be able to generalize and understand the content and educational technology of technology, to what Meaning of education along with technology. In fact, the need for the interference between the two areas of mathematics and technology is the dominance of teachers in both domains. In other words, teaching along with technology means that as long as the teacher thinks about specific mathematical concepts, one must simultaneously contemplate how to make mathematical concepts comprehensible to his students using the technology of expression In this research, we have tried to highlight the role of teachers in identifying the achievements of using technology in mathematics education in order to better realize this important issue.
Dynamic Spectrum Management through Resource Virtualization with M2M Communications

Wireless spectrum licensing has increased due to the continuous evolution and use of cellular technology. The increase in the number of mobile-connected devices and global data traffic demand has led to a significant increase in demand for spectrum access with studies showing that there is unexploited capacity in the spectrum. This is especially critical for 5G networks where the service requirements are extremely stringent. To that end, this article proposes dynamic spectrum management through the combination of two innovative architectures, wireless resource virtualization (WRV) and machine-to-machine (M2M) communications. WRV allows for better utilization of the spectrum, while reducing both the capital and operational expenditures. On the other hand, M2M communications can help boost capacity and improve quality of service by leveraging spectrum access across multiple radio technologies. In this article, a brief discussion of multi-radio access technology heterogeneous networks is given. Then the problem of dynamic spectrum management through resource virtualization with M2M communications is described. To the best of our knowledge, such a combined framework has not been previously proposed. Two different algorithms are proposed to evaluate the performance of the considered architecture, namely a decomposition- based algorithm and a greedy-based algorithm. Simulation results show that such architecture can boost the overall capacity of the system by achieving higher data rates. Moreover, it is shown that the number of possibly supported M2M pairs is increased while using the same spectrum.
Bone Healing in Rabbit Calvaria Defects Using a Synthetic Bone Substitute: A Histological and Micro-CT Comparative Study

Bioactive alloplastic materials, like beta-tricalcium phosphate (β-TCP) and calcium sulfate (CS), have been extensively researched and are currently used in orthopedic and dental bone regenerative procedures. The purpose of this study was to compare the performance of EthOss versus a bovine xenograft and spontaneous healing. The grafting materials were implanted in standardized 8 mm circular bicortical bone defects in rabbit calvariae. A third similar defect in each animal was left empty for natural healing. Six male rabbits were used. After eight weeks of healing, the animals were euthanized and the bone tissue was analyzed using histology and micro-computed tomography (micro-CT). Defects treated with β-TCP/CS showed the greatest bone regeneration and graft resorption, although differences between groups were not statistically significant. At sites that healed spontaneously, the trabecular number was lower (p < 0.05) and trabecular separation was higher (p < 0.05), compared to sites treated with β-TCP/CS or xenograft. Trabecular thickness was higher at sites treated with the bovine xenograft (p < 0.05) compared to sites filled with β-TCP/CS or sites that healed spontaneously. In conclusion, the novel β-TCP/CS grafting material performed well as a bioactive and biomimetic alloplastic bone substitute when used in cranial defects in this animal model.
Spinal Epidural Arteriovenous Fistula with Perimedullary Venous Reflux: Clinical and Neuroradiologic Features of an Underestimated Vascular Disorder

Thirteen consecutive patients were diagnosed with deep lumbosacral spinal dural arteriovenous fistula at a single center between 2006 and 2018. Paraparesis was present in 12 (92%) patients. Sphincter dysfunction and sensory symptoms were observed in 7 (54%) and 6 (46%) patients, respectively. The mean duration of symptoms was 6 ± 8 months. Congestive myelopathy on MR imaging was present in all patients. Prominent arterialized perimedullary veins were demonstrated in only 3 cases. Time-resolved contrast-enhanced dynamic MRA revealed arterialized perimedullary veins and an arterialized ventrolateral epidural pouch in 9/10 (90%) patients, mostly located ventrolaterally. The authors conclude that time-resolved contrast-enhanced dynamic MRA is a powerful diagnostic tool for identifying arterialized perimedullary veins as well as an arterialized ventrolateral epidural pouch. BACKGROUND AND PURPOSE: The purpose of this study was to discuss the clinical and radiologic characteristics of spinal epidural arteriovenous fistulas (SEAVF) and demonstrate their specific angiomorphology in a single-center series. MATERIALS AND METHODS: Thirteen consecutive patients were diagnosed with SEAVF at RWTH Aachen University Hospital between 2006 and 2018 and were included in this study. All patients had MR imaging and DSA before treatment; 10 of these 13 patients received contrast-enhanced MRA (CE-MRA). RESULTS: The mean patient age was 72 ± 8 years. Paraparesis was present in 12 (92%) patients. Sphincter dysfunction and sensory symptoms were observed in 7 (54%) and 6 (46%) patients, respectively. The mean duration of symptoms was 6 ± 8 months. Congestive myelopathy on MR imaging was present in all patients. Prominent arterialized perimedullary veins were demonstrated in only 3 cases. CE-MRA revealed arterialized perimedullary veins and an arterialized epidural pouch in 9/10 (90%) patients, mostly located ventrolaterally. DSA demonstrated a multisegmental extension of the arterialized ventrolateral epidural pouch in 6 (46%) cases. An intradural radicular drainage vein was localized distant from the original fistula point in 3 (23%) patients. CONCLUSIONS: Congestive myelopathy with an acute/subacute clinical course was the dominant finding in spinal epidural arteriovenous fistulas. CE-MRA is a powerful diagnostic tool for identifying arterialized perimedullary veins as well as an arterialized epidural pouch. While arterialized perimedullary veins frequently present with only mild enlargement and elongation in spinal epidural arteriovenous fistulas, the arterialized epidural pouch is frequently located ventrolaterally and may extend over several vertebral levels. DSA remains the criterion standard to precisely visualize a spinal epidural arteriovenous fistula and its intradural radicular drainage vein, which may be located distant from the fistulous point.
Ethical conflict among nurses working in the intensive care units

Background: Ethical conflict is a barrier to decision-making process and is a problem derived from ethical responsibilities that nurses assume with care. Intensive care unit nurses are potentially exposed to this phenomenon. A deep study of the phenomenon can help prevent and treat it. Objectives: This study was aimed at determining the frequency, degree, level of exposure, and type of ethical conflict among nurses working in the intensive care units. Research design: This was a descriptive cross-sectional research. Participants and research context: In total, 382 nurses working in the intensive care units in Iranian hospitals were selected using the random sampling method. Data were collected using the Ethical Conflict in Nursing Questionnaire-Critical Care Version (Persian version). Ethical considerations: This study was approved by the Medical Research Ethics Committee. Ethical considerations such as completing the informed consent form, ensuring confidentiality of information, and voluntary participation were observed. Findings: The results showed that the average level of exposure to ethical conflict was 164.39 ± 79.06. The most frequent conflict was related to “using resources despite believing in its futility,” with the frequency of at least once a week or a month (68.6%, n = 262). The most conflictive situation was violation of privacy (76.9%, n = 294). However, the level of exposure to ethical conflict according to the theoretical model followed was the situation of “working with incompetent staff. ” The most frequently observed type of conflict was moral dilemma. Conclusion: The moderate level of exposure to ethical conflict was consistent with the results of previous studies. However, the frequency, degree, and type of ethical conflict were different compared to the results of other studies. Recognizing ethical conflict among intensive care unit nurses can be useful as it allows to consolidate those measures that favor low levels of ethical conflict, design appropriate strategies to prevent ethical conflicts, and improve the nursing work environment.