Miracle-dz/UniFAR-FTUs huggingface dataset:
The fiscal impact of EU immigration on the tax-financed welfare state: Testing the ‘welfare burden’ thesis

The European Union’s rules on free movement of people and the right to cross-border welfare are increasingly contested and have evoked one of the most salient debates in EU politics. The assumption that EU immigrants pose a net ‘welfare burden’ on the host member state has sounded loud and wide in recent years. This calls for an empirical test. In this article, we examine the fiscal impact of EU immigration on the universalistic, tax-financed welfare state of Denmark. We analyse EU citizens’ contribution to and consumption of welfare benefits between 2002 and 2013 on the basis of a unique dataset of administrative data, consisting of repeated cross sections of 100% of the EU population residing in Denmark. We find that EU immigrants made a significant positive net contribution to the Danish welfare state over the long time span examined and thus reject the ‘welfare burden’ thesis for the crucial case of Denmark.
Exploring heterogeneity among backpackers in hostels

This study’s goal was to validate the core dimensions of hostel service quality and to test whether each dimension has a different impact on behavioural intentions across guest segments defined by age, gender and nationality. This research targeted guests staying at Lisbon hostels (N = 313). Both covariance-based structural equation modelling (SEM) and variance-based SEM were used to meet this study’s exploratory and confirmatory objectives. The results confirm that service quality in this sector is a multidimensional construct comprising four core dimensions: quality of staff, social atmosphere, hostel tangibles and city connection. These four aspects are relevant when explaining levels of satisfaction, recommendation and revisiting intentions. Moreover, these dimensions allow the identification of differences across market segments in regards to responses to marketing outcomes, thus providing useful insights into how best to meet guests’ needs.
Elevated Mean Diffusivity in the Left Hemisphere Superior Longitudinal Fasciculus in Autism Spectrum Disorders Increases with More Profound Language Impairment

The cause of autism continues to be uncertain and conventional imaging is not helpful. These investigators used DTI to study the language-related white matter tracts in a subset of patients with autism and language impairments. Eighteen patients were compared with 25 controls and showed abnormal DTI parameters in the superior longitudinal fasciculus, particularly in its temporal portion and on the left side. Thus, the white matter subserving language in these patients was abnormal. BACKGROUND AND PURPOSE: Language impairments are observed in a subset of individuals with ASD. To examine microstructural brain white matter features associated with language ability in ASD, we measured the DTI parameters of language-related white matter tracts (SLF) as well as non-language-related white matter tracts (CST) in children with ASD/+LI and ASD/−LI) and in TD. MATERIALS AND METHODS: Eighteen children with ASD/−LI (age range, 6.7–17.5 years), 17 with ASD/+LI (age range, 6.8–14.8 years), and 25 TD (age range, 6.5–18 years) were evaluated with DTI and tractography. Primary DTI parameters considered for analysis were MD and FA. RESULTS: There was a main effect of diagnostic group on age-corrected MD (P < .05) with ASD/+LI significantly elevated compared with TD. This was most pronounced for left hemisphere SLF fiber tracts and for the temporal portion of the SLF. There was significant negative correlation between left hemisphere SLF MD values and the clinical assessment of language ability. There was no main effect of diagnostic group or diagnostic group X hemisphere interaction for FA. Although there was a main effect of diagnostic group on values of MD in the CST, this did not survive hemispheric subanalysis. CONCLUSIONS: Abnormal DTI parameters (specifically significantly elevated MD values in ASD) of the SLF appear to be associated with language impairment in ASD. These elevations are particularly pronounced in the left cerebral hemisphere, in the temporal portion of the SLF, and in children with clinical language impairment.
Response to Anti-HCV Therapy in HIV–HCV-Coinfected Patients: Does the Lipid Profile Really have an Effect?

Background Because high serum low-density lipoprotein (LDL) and total cholesterol concentrations before treatment have been found to be significant positive prognostic factors for a sustained virological response to HCV therapy in monoinfected patients, the aim of this study was to assess this relationship in HIV–HCV-coinfected patients. Methods Pretreatment fasting lipid parameters (in particular total cholesterol, LDL, high-density lipoprotein [HDL], apolipoprotein B [apoB] and triglycerides [TG]) were assessed in 315 patients from the French National Agency for Research on AIDS and Viral Hepatitis (ANRS) HC02-Ribavic therapeutic trial. Results There was a significant correlation between pretreatment lipid parameters and steatosis (total cholesterol r=-0.23, P<0.0001; LDL r=-0.23, P<0.0001; HDL r=-0.28, P<0.0001; and TG r=0.18, P=0.002), but not with fibrosis. None of these lipid parameters were significant predictors of a sustained virological response to HCV therapy, even after adjustment for the type of interferon treatment and for the main known prognostic factors for a response to HCV therapy. Conclusions The possible effect of lipid metabolism on virological response is outweighed by other prognostic factors that affect response to HCV therapy in the ANRS HC02-Ribavic study.
State of the art in interstitial pneumonia with autoimmune features: a systematic review on retrospective studies and suggestions for further advances

The term interstitial pneumonia with autoimmune features (IPAF) has been proposed to define patients with interstitial lung disease (ILD) associated with autoimmune signs not classifiable for connective tissue diseases (CTDs). This new definition overcomes previous nomenclatures and provides a uniform structure for prospective studies through specific classification criteria. This work evaluates the characteristics of IPAF patients reported in the literature, to highlight potential limits through a comparative analysis and to suggest better performing classification criteria. Four retrospective studies on the IPAF population have been considered. The study subjects differed in age, sex, smoking habit, ILD pattern and outcomes. Another important difference lies in the diverse items considered in the classification criteria. The retrospective design of the studies and the absence from some of them of a rheumatologist clearly involved in the diagnosis may have influenced the data, but current IPAF criteria seem to include a rather heterogeneous population. To overcome these discrepancies, this review suggests a limitation in the use of single items and the exclusion of extremely specific CTD criteria. This should avoid the definition of IPAF for those diseases at different stages or at early onset. The investigation of a functional or morphological cut-off of pulmonary involvement would be useful. IPAF retrospective cohorts show numerous differences between them. We propose some ideas to improve IPAF criteria http://ow.ly/eubC30jlGJO
Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein

The lamin B receptor (LBR) is an inner nuclear membrane protein with a structural function interacting with chromatin and lamins, and an enzymatic function as a sterol reductase. Heterozygous LBR mutations cause nuclear hyposegmentation in neutrophils (Pelger anomaly), while homozygous mutations cause prenatal death with skeletal defects and abnormal sterol metabolism (Greenberg dysplasia). It has remained unclear whether the lethality in Greenberg dysplasia is due to cholesterol defects or altered nuclear morphology. To answer this question we characterized two LBR missense mutations and showed that they cause Greenberg dysplasia. Both mutations affect residues that are evolutionary conserved among sterol reductases. In contrast to wildtype LBR, both mutations failed to rescue C14 sterol reductase deficient yeast, indicating an enzymatic defect. We found no Pelger anomaly in the carrier parent excluding marked effects on nuclear structure. We studied Lbr in mouse embryos and demonstrate expression in skin and the developing skeletal system consistent with sites of histological changes in Greenberg dysplasia. Unexpectedly we found in disease-relevant cell types not only nuclear but also cytoplasmatic LBR localization. The cytoplasmatic LBR staining co-localized with ER-markers and is thus consistent with the sites of endogeneous sterol synthesis. We conclude that LBR missense mutations can abolish sterol reductase activity, causing lethal Greenberg dysplasia but not Pelger anomaly. The findings separate the metabolic from the structural function and indicate that the sterol reductase activity is essential for human intrauterine development.
Analysis Of Type And Severity Of Traffic Crashes At Signalized Intersections Using Tree-based Regression And Ordered Probit Models

Many studies have shown that intersections are among the most dangerous locations of a roadway network. Therefore, there is a need to understand the factors that contribute to traffic crashes at such locations. One approach is to model crash occurrences based on configuration, geometric characteristics and traffic. Instead of combining all variables and crash types to create a single statistical model, this analysis created several models that address the different factors that affect crashes, by type of collision as well as injury level, at signalized intersections. The first objective was to determine if there is a difference between important variables for models based on individual crash types or severity levels and aggregated models. The second objective of this research was to investigate the quality and completeness of the crash data and the effect that incomplete data has on the final results. A detailed and thorough data collection effort was necessary for this research to ensure the quality and completeness of this data. Multiple agencies were contacted and databases were crosschecked (i.e. state and local jurisdictions/agencies). Information (including geometry, configuration and traffic characteristics) was collected for a total of 832 intersections and over 33,500 crashes from Brevard, Hillsborough and Seminole Counties and the City of Orlando. Due to the abundance of data collected, a portion was used as a validation set for the tree-based regression. Hierarchical tree-based regression (HTBR) and ordered probit models were used in the analyses. HTBR was used to create models for the expected number of crashes for collision type as well as injury level. Ordered probit models were only used to predict crash severity levels due to the ordinal nature of this dependent variable. Finally, both types of models were used to predict the expected number of crashes.
Gender, Politics, News: A Game of Three Sides

• The only contemporary book focusing on the relationships between gender, politics, and news media which takes a global perspective • An analysis of political journalism as a practice and the development of the field in terms of gendered workplace cultures • Offers a solid framework for understanding women’s political representation, including real world case studies of women’s campaigns for the top political job across a range of different geographies and contexts • Coverage of hot-button issues, such as political scandal and the role of new and social media in politics and elections, makes this a highly relevant and current work with resonances for a wide audience
Experimental stressors alter hypertonic saline-evoked masseter muscle pain and autonomic response.

AIMS To test in a randomized controlled trial, if hypertonic saline (HS)-evoked pain and autonomic function are modulated by either a cold pressor test (CPT) or mental arithmetic stress induced by a paced auditory serial addition task (PASAT). METHODS Fourteen healthy women participated in three sessions. Pain was induced by two 5% HS infusions (5 minutes each, 30 minutes apart) infused into the masseter muscle. During the second HS infusion, pain was modulated by PASAT, CPT, or control (HS alone). HS-evoked pain intensity was scored on a 0 to 10 numeric rating scale (NRS). Heart rate variability (HRV) and hemodynamic measures were recorded noninvasively (Task Force Monitor). Data were analyzed using repeated measurements ANOVAs and Spearman correlation analysis. RESULTS HS-evoked pain was significantly and similarly reduced by both PASAT (30.8 ± 27.6%; P < .001) and CPT (35.8 ± 26.6%; P < .001) compared with the control session (9.0 ± 30.5%; P > .05). PASAT and CPT increased the heart rate compared with control (P <.001). CPT reduced measures of vagal activity: Root mean square successive difference, high-frequency (HF) power, and coefficient of HF component variance compared with an internal control, ie, the first HS infusion (P < .05), while PASAT did not alter any of these HRV measures (P > .05). CONCLUSION CPT and PASAT reduced HS-evoked masseter muscle pain and altered the autonomic response. The increase in heart rate following CPT and PASAT may be caused by different mechanisms. CPT reduced measures of efferent cardiac vagal (parasympathetic) activity, while the PASAT-induced increase in heart rate, but unchanged HRV, may suggest neurohumoral activation.
Setaria cervi dual specific phosphatase: characterization and its effect on eosinophil degranulation

SUMMARY Setaria cervi, a bovine filarial parasite contains significant acid phosphatase (AcP) activity in its various life stages. Two forms of AcP were separated from somatic extract of adult female parasite using cation exchange, gel filtration and concavalin affinity chromatography. One form having a molecular mass of 79 kDa was characterized as dual specific protein tyrosine phosphatase (ScDSP) based on substrate specificity and inhibition studies. With various substrates tested, it showed significant activity in the order of phospho-L-tyrosine>pNPP>ADP>phospho-L-serine. Inhibition by orthovanadate, fluoride, molybdate, and zinc ions further confirms protein tyrosine phosphatase nature of the enzyme. Km and Vmax determined with various substrates were found to be 16·66 mM, 25·0 μM/ml/min with pNPP; 20·0 mM, 40·0 μM/ml/min with phospho-L-tyrosine and 27·0 mM, 25·0 μM/ml/min with phospho-L-serine. KI with pNPP and sodium orthovanadate (IC50 33·0 μM) was calculated to be 50·0 mM. Inhibition with pHMB, silver nitrate, DEPC and EDAC suggested the presence of cysteine, histidine and carboxylate residues at its active site. Cross-reactivity with W. bancrofti-infected sera was demonstrated by Western blotting. ScDSP showed elevated levels of IgE in chronic filarial sera using ELISA. Under in vitro conditions, ScDSP resulted in increased effector function of human eosinophils when stimulated by IgG, which showed a further decrease with increasing enzyme concentration. Results presented here suggest that S. cervi DSP should be further studied to determine its role in pathogenesis and the persistence of filarial parasite.
Economic globalization, inequality, and protest movements under capitalist political regimes, 1970–2007

This article examines the impacts of globalization on protest movements. Highlighting the nature of capitalist political regimes in which capitalist societies and political institutions are deeply interconnected, I argue that the relationship between globalization and protest is profoundly constrained by two domestic conditions: the distribution of material resources and the type of political regime. Based on time-series, cross-sectional (TSCS) data in a global sample for the period 1970–2007, the findings indicate that globalization is more likely to increase protest in egalitarian democracies; globalization is not systematically associated with protest under dictatorships, except in the case of a highly unequal dictatorship in which globalization appears to revitalize protest, and hyperglobalization radically diminishes the possibility of protest, especially in democracies.
Sources of Dependence and Strategies to Innovate: Evidence from Video Game SMEs

Recent studies call for reconsideration of the predictions of resource dependence theory, in light of contemporary industrial and economic environments. This study accordingly investigates the influence of dependence on the strategic choice to innovate by focusing on a rarely studied topic, namely, the sources of dependence. In studying small and medium‐sized video game enterprises, this paper provides empirical validation of dependence phenomena. These companies have limited resources, which inevitably creates dependence, exacerbated in innovative contexts because of the prevalence of negative effects, such as opportunism, abuse of power, limited innovation, or inequitable distributions of economic value. To deal with these negative effects, some enterprises use cooperation or integration strategies to try to minimize their dependence. The strategic choice then might be conditioned. The results of a comparative and qualitative study of five video game developers show that a lack of resources and skills is the primary source of dependence. In addition, a hierarchy of sources of dependence seems to guide the strategic choices of developers to innovate.
Cultural Attitudes, Knowledge, and Skills of a Health Workforce

This study describes cultural attitudes, knowledge, and skill of 409 health care workers using the Ethnic Attitude Scale, the Cultural Self-Efficacy Scale, and a demographic inventory. Findings suggest cultural knowledge and educational preparation of the health worker may influence cultural skills. Workers that were most confident in their cultural skills in working with other cultural groups were more confident in knowledge of cultural concepts and had higher education levels. The results also suggest gaps in workers’ knowledge of other cultures and how to care for them in culturally sensitive ways. Educational interventions may enhance workers’ knowledge. Whether such enhanced knowledge yields improved patient care outcomes remains to be answered.
Learning Cost-Effective and Interpretable Treatment Regimes

Decision makers, such as judges, make crucial choices regarding judicial bail decisions on a daily basis. Such decisions typically involve careful assessment of the subject’s (or defendant’s) condition, analyzing the costs associated with the possible actions, and the nature of the consequent outcomes. Further, there might be costs associated with the assessment of the subject’s condition itself. For instance, a judge deciding if a defendant should be granted bail studies the criminal records of the defendant, and enquires for additional information (e.g., defendant’s personal life or economic status) if needed. She then recommends a course of action (or treatment)1 that trades off the risk with granting bail to the defendant (the defendant may commit a new crime when out on bail) with the cost of denying bail (adverse effects on defendant, or defendant’s family, cost of jail to the county).
Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis

Murine AIDS (MAIDS) is a disease that shows many similarities with human AIDS. Several immunological parameters of the disease have been analyzed and genetic studies have mapped a gene (or genes) of resistance in the H‐2 complex and shown that the genetic background of the mouse can significantly modify some features of the disease. The etiologic agent of MAIDS is a defective murine leukemia virus that seems able to induce disease in the absence of virus replication. This defective virus induces proliferation of its target cells and the cell expansion was found to be oligoclonal, thus suggesting that the immunodeficiency observed in these mice is a paraneoplastic syndrome. The excellent response of MAIDS mice to antineoplastic agents is consistent with this notion. This animal model has already been useful in stimulating the emergence of novel questions and the formulation of new hypotheses about human AIDS, namely about the role of defective HIV, the role of HIV replication in the progression of the disease, and the importance to identify the target cells of HIV in vivo. Although MAIDS and AIDS are not identical and are induced by retroviruses of different classes, the availability of such a model in an easily accessible small animal species, whose genetics is very sophisticated, may be instrumental in understanding the pathogenesis of AIDS if some of the cellular and molecular affected pathways are common in both diseases. —Jolicoeur, P. Murine acquired immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis. FASEB J. 5: 2398–2405;1991.
Ultrasonography and Computed Tomographic Manifestations of Abdominal Sarcoidosis in Children

Objectives: Sarcoidosis is a multisystem, granulomatous inflammatory disease affecting both pediatric and adult patients. So far in children, very few radiological descriptions of abdominal sarcoidosis manifestations have been reported. The present study describes the frequency and the appearance of abdominal radiologic manifestations in pediatric patients with histologically proven sarcoidosis. Methods: We reviewed retrospectively all of the radiological examinations of 22 patients ages 1 to 15 years at diagnosis with proven sarcoidosis evaluated in a university pediatric hospital between 1994 and 2014. The locations of biopsies and the angiotensin-converting enzyme level were reported. The size, shape, and parenchymal homogeneity of the liver and spleen, the presence of abdominal lymph nodes, and abnormalities of the gastrointestinal tract were tabulated. Results: The study included 22 children (mean age: 9.9 ± 2.8 years). The liver was the most frequent location of biopsy (12/22), even without radiological involvement. Abdominal manifestations were present in 11 of 22 children with sarcoidosis. Hepatomegaly was the most frequent abnormality, reported in 8 of 11 cases either homogeneous (n = 7) or nodular (n = 1). Homogeneous lymph node enlargement was noted in 6 of 11 cases and splenomegaly in 4 of 11 cases. No calcification was observed. All patients with initial abdominal sarcoidosis had simultaneous thoracic involvement. Conclusions: Abdominal manifestations in children sarcoidosis are frequent but often nonspecific. Nodular hepatosplenomegaly is rare. All of our patients with abdominal abnormalities had a more specific associated thoracic involvement. Awareness of this association could assist the clinicians in assessing the initial diagnosis of abdominal sarcoidosis in children.
Tris(propane-1,2-diamine-κ2 N,N′)nickel(II) tetracyanidoplatinate(II)

In the title compound, [Ni(C3H10N2)3][Pt(CN)4], the [Pt(CN)4]2− anion with the environment of the PtII atom, lying on a mirror plane, is square planar, whereas the NiII atom in the [Ni(C3N2H10)3]2+ cation, also lying on a mirror plane, has a slightly distorted octahedral coordination geometry. Three chiral 1,2-diaminopropane molecules, which are disordered equally over two sets of positions, adopt Δ(δδδ) and Δ(λλλ) configurations. The average Ni—N and Pt—C bond lengths are 2.131 (10) and 1.988 (10) Å, respectively. The cations and anions are connected by N—H⋯N hydrogen bonds.