Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacotherapy for erectile dysfunction.

INTRODUCTION Pharmacotherapy is the usual initial therapy for most men with erectile dysfunction. AIM To review the current data relating to the efficacy, tolerability and safety of drugs used in the treatment of men with erectile dysfunction. METHODS A critical review of the literature relating to the use of pharmacotherapeutic agents was undertaken by a committee of eight experts from five countries, building on prior reviews. MAIN OUTCOME MEASURES Expert opinion and recommendations were based on grading of evidence-based literature, internal committee dialogue, open presentation, and debate. RESULTS Almost all currently available evidence relates to sildenafil, tadalafil, and vardenafil. Phosphodiesterase type 5 (PDE5) inhibitors are first-line therapy for most men with erectile dysfunction who do not have a specific contraindication to their use. There is no evidence of significant differences in efficacy, safety, and tolerability between the PDE5 inhibitors and apomorphine. Intracavernosal injection therapy with alprostadil should be offered to patients as second line therapy for erectile dysfunction. Intraurethral alprostadil is a less effective treatment than intracavernosal alprostadil for the treatment of men with erectile dysfunction. CONCLUSIONS PDE5 inhibitors are effective, safe, and well-tolerated therapies for the treatment of men with erectile dysfunction. Apomorphine, intracavernosal injection therapy with alprostadil, and intraurethral alprostadil are all effective and well-tolerated treatments for men with erectile dysfunction. We recommend some standardization of the assessment of psychosocial outcomes within clinical trials in the field of erectile dysfunction.
Do strategic groups explain differences in multimarket competition spillovers?

Multimarket competition theory states that if two firms coincide in multiple markets, the level of rivalry between them changes, which, in turn, affects their performance. This article extends this perspective in two ways. We first propose that multimarket competition affects not only the rivalry levels of multimarket rivals but also the rivalry experienced by the other firms present in the markets in which these multimarket rivals operate. We refer to these indirect effects as multimarket competition spillovers, and we propose that they affect firm performance. Second, we conjecture that multimarket competition spillovers are more intense when the firm that creates the spillover and the one that receives it belong to the same strategic group. Our analyses of the Spanish retail banking sector show that the performance of firms is significantly affected by the multimarket competition spillovers of rivals that belong to the same strategic group.
A Reassessment of the Finance & Growth Nexus Using Monte Carlo Evidence

The small sample performance of system Generalized Method of Moments (GMM) and an alternative Transformed Maximum Likelihood (TML) estimator in Monte Carlo simulations is investigated, implementing a data generating process that tracks important features inherent in dynamic panels used in finance & growth regressions. It is allowed for weak exogeneity of the additional control variable and violations of initial mean stationarity. System GMM estimators tend to be biased towards Ordinary Least Squares (OLS) estimates when either the variance of the unobserved heterogeneity is large compared to the variance of the idiosyncratic error term or when initial mean stationarity is violated. Collapsing the instruments matrix tends to improve on mean bias and root mean squared error (rmse), reducing the overall instrument count. TML coefficients are generally downward biased but robust to initial mean stationarity violations and more reliable in estimating the lagged dependent variable. Results from an application to the finance & growth literature suggest that a positive and monotonic relationship might well be an artifact of an upward bias of system GMM towards OLS estimates. An inverse U-shaped relationship is also not statistically robust.
Feature selection based on antlion optimization algorithm

In this work, a model for feature selection based on antlion optimization (ALO) is proposed. Feature sets always have redundant, dependant and correlated features that badly affect the classification performance and increases training time. Therefore, feature selection becomes a must to remove irrelevant features and enhances classification generalization. Wrapper-based feature selection is a method that selects a feature set maximizing a given classifier performance criteria and hence requires efficient searching method to find optimal feature combinations. Antlion optimization is a recently proposed swarm optimizer with good searching capability. ALO is exploited in this study as searching method to find optimal feature set maximizing classification performance. ALO algorithm mimics the hunting mechanism of antlions in nature. The proposed model is evaluated using different evaluation criteria on 18 different data sets and is compared to two common search methods namely particle swarm optimization (PSO) and genetic algorithm (GA) and proves an advance in classification performance and selected feature set.
Explaining the Link Between Emotional Labor and Turnover Intentions: The Role of In-Depth Communication

ABSTRACT This study investigates the relationships between three different emotional labor strategies (surface acting, deep acting, and genuine emotions) and turnover intentions and introduces the role of in-depth communication with colleagues as a potential moderator. This study was administered to employees in four Chinese hotel companies. Frontline employees were asked to participate in the survey and 216 valid responses were obtained for data analysis. The results showed that surface acting and deep acting were associated with turnover intentions, and in-depth communication with colleagues moderated the relation between deep acting and turnover intentions. Although there was not a direct effect of genuine emotions on turnover intentions, in-depth communication was a significant moderator of this relation. These findings extend previous literature by demonstrating the role of in-depth communication in shaping employees’ retention.
The therapisation of social justice as an emotional regime: implications for critical education

Purpose The purpose of this paper is to sketch out what one can see as the emerging “therapeutic turn” in a wide range of areas of contemporary social life including education, especially in relation to understandings of vulnerability and social justice, and then poses the question of what emotional regime has accompanied the emergence of this “therapization” movement, making emotional life in schools the “object-target” for specific technologies of power. Design/methodology/approach The psychologization of social problems has been very much in evidence in the development of educational policies and practices – an approach which not only pathologizes social problems as individual psychological deficiencies or traits, but also obscures the recognition of serious structural inequalities and ideological commitments that perpetuate social injustices through educational policy and practice. In the present paper, the author adopts a different perspective, that of the history, sociology and politics of emotions and affects to show how and why the therapization of social justice is part of the conditions for the birth of particular forms of biopower in schools. Findings There is an urgent need to expose how psychologized approaches that present social justice as an individualizing responsibility are essentially depoliticizing vulnerability by silencing the shared complicities. It is argued, then, that it is crucial to pay attention to the political and structural dimensions of vulnerability. Originality/value Attending to the emotional regime of therapization of social justice has important implications to counter forms of biopower that work through processes of normalization.
No meaningful association between suicidal behavior and the use of IL-17A-neutralizing or IL-17RA-blocking agents

ABSTRACT Introduction: An emerging class of agents blocking IL-17 signaling represents a very promising therapeutic approach. One of these agents, brodalumab, has been associated with an increased risk of suicide behavior. Areas covered: This review sought to provide an overview strictly focused on suicide behavior signals related to the use of IL-17 agents. Data collection regarding this peculiar safety aspect was primarily based on: (i) a revision of safety outcomes belonging to phase II and phase III trials; (ii) a systematic search using the Pubmed Medline database; and (iii) collecting recent data issued as posters or communications in eminent international meetings. Expert opinion: Whilst secukinumab and ixekizumab were not associated with increased signal of suicidal behavior, being recently approved for the treatment of psoriasis by EMA and FDA, brodalumab raised concern because of suicide behavior cases that led to pause momentarily its development program during pre-marketing stage before obtaining the positive recommendation by an FDA advisory panel for its approval. Indeed, a careful re-evaluation of brodalumab safety profile is being performed and no evidence clarified a significant association or a pathogenic mechanism linking brodalumab treatment to the risk of suicidal behavior, suggesting that cases of suicidal behavior accidentally occurred during brodalumab trials.
Somato‐motor inhibitory processing in humans: a study with MEG and ERP

The go/nogo task is a useful paradigm for recording event‐related potentials (ERPs) to investigate the neural mechanisms of response inhibition. In nogo trials, a negative deflection at around 140–300 ms (N2), which has been called the ‘nogo potential’, is elicited at the frontocentral electrodes, compared with ERPs recorded in go trials. In the present study, we investigated the generators of nogo potentials by recording ERPs and by using magnetoencephalography (MEG) simultaneously during somatosensory go/nogo tasks to elucidate the regions involved in generating nogo potentials. ERP data revealed that the amplitude of the nogo‐N140 component, which peaked at about 155 ms from frontocentral electrodes, was significantly more negative than that of go‐N140. MEG data revealed that a long‐latency response peaking at approximately 160 ms, termed nogo‐M140 and corresponding to nogo‐N140, was recorded in only nogo trials. The equivalent current dipole of nogo‐M140 was estimated to lie around the posterior part of the inferior frontal sulci in the prefrontal cortex. These results revealed that both nogo‐N140 and nogo‐M140 evoked by somatosensory go/nogo tasks were related to the neural activity generated from the prefrontal cortex. Our findings combining MEG and ERPs clarified the spatial and temporal processing related to somato‐motor inhibition caused in the posterior part of the inferior frontal sulci in the prefrontal cortex in humans.
The Role of MAP1A Light Chain 2 in Synaptic Surface Retention of CaV2.2 Channels in Hippocampal Neurons

Cav2.2 channels are localized at nerve terminals where they play a critical role in neurotransmission. However, the determinant that controls surface retention of these channels has not been identified. Here, we report that presynaptic surface localization of Cav2.2 is mediated through its interaction with light chain 2 (LC2) of microtubule-associated protein MAP1A. Deletion of a 23-residue binding domain within the Cav2.2 C terminus resulted in reduced synaptic distribution of the mutant channels. Using an antibody generated against an extracellular epitope of Cav2.2, we demonstrate that interfering the interaction with LC2 reduced surface expression of endogenous Cav2.2 at presynaptic boutons. In addition, the disruption of LC2–Cav2.2 coupling reduced Ca2+-influx into nerve terminals through Cav2.2 and impaired activity-dependent FM4-64 uptake. The treatments of neurons with Latrunculin A to disrupt actin filaments resulted in reduced density of surface Cav2.2-positive boutons. Furthermore, LC2NT, a LC2 truncated mutant lacking the actin-binding domain, could not rescue Cav2.2 surface expression after suppressing LC2 expression with RNAi. Because actin filaments are major cytomatric components at the presynaptic boutons, these observations suggest a mechanism by which LC2 provides anchoring of surface Cav2.2 to the actin cytoskeleton, thus contributing to presynaptic function.
Differential regulation of leptin receptor expression by insulin and leptin in neuroblastoma cells.

Leptin exerts its effects by interacting with specific membrane receptors (Ob-R). We studied the exact localization of long intracellular domain form (Ob-Rb) in human brain. In addition, we analyzed the regulatory features of Ob-Rb expression in two neuroblastoma cell lines. The Ob-Rb mRNAs were abundant in putamen, frontal lobe, medulla, cerebral cortex, cerebellum, thalamus, hippocampus, corpus callosum, caudate nucleus, and amygdala, indicating that Ob-Rb transcripts are expressed differently from that of other Ob-R isoforms. In SK-N-MC cells, the expression of Ob-Rb mRNA was induced by increasing doses of insulin, and the maximum amount of mRNA expression was 9.4-fold higher in the presence of insulin (100 nM for 24 h), compared to the absence of insulin. In IMR32 cells, the transcripts were increased 4.0-fold when cells were incubated with 1 nM of insulin for 48 h. In contrast, Ob-Rb expression in IMR32 cells decreased to 18% of control following a 24-h incubation period with 50 ng/mL of leptin, compared to incubation in the absence of leptin. These results indicate that expression of Ob-Rb is differentially regulated by inhibitory signals of energy balance in neuroblastoma cells. The identification of the novel regulatory mechanisms involving the Ob-Rb isoform by insulin and leptin now makes it possible to elucidate the underlying mechanisms involving increased food intake and uncontrolled energy balance associated with leptin resistance in obese individuals.
Detection, pathogenesis, and prevention of damage to human granulocytes caused by interaction with nylon wool fiber. Implications for filtration leukapheresis.

Granulocytes collected by reversible adhesion to nylon wool fiber (NWF) function relatively well in standard in vitro tests; however, they have an abnormally shortened survival time in the circulation. Assuming that this rapid disappearance represents clearance and that recognition by phagocytes is important for such clearance, we used an autologous in vitro cell:cell recognition assay to determine whether phagocytes can detect cellular changes induced by exposure of normal granulocytes to NWF. Human granulocytes incubated with NWF 1 h at 37 degrees C, eluted with 20% acid citrate dextrose plasma, and washed stimulated the hexose monophosphate shunt activity of normal granulocytes an average of twofold (193+/-40% of controls), indicating a recognition response. NWF-induced granulocyte recognition was not dependent on plasma factors or activated complement components but was dependent on the time that the granulocyte was on the NWF and was maximal by 60 min of exposure. After elution from NWF, granulocytes demonstrated resting glucose oxidation rates only slightly higher than normal; however, during the first 20 min of exposure to NWF, granulocytes increased their rate of (14)CO(2) production from [1-(14)C]glucose three- to five-fold. Therefore, experiments were performed to determine whether toxic oxygen metabolites produced by NWF-adherent cells might contribute to recognition. The results showed that (a) normal granulocytes exposed to NWF in the presence of scavengers of superoxide anion (superoxide dismutase) or free radicals (ascorbate, mannitol, or benzoate) and washed before assay did not stimulate glucose oxidation of indicator granulocytes; and (b) NWF granulocytes prepared from cells unable to generate high levels of toxic oxygen metabolites, i.e. cells prepared anaerobically or from a patient with chronic granulomatous disease, also failed to stimulate indicator granulocytes. Human granulocytes placed in contact with NWF show an oxidative burst and become recognizable to other phagocytes. Free radical scavengers are effective in minimizing this recognition conferred on NWF-procured granulocytes.
The nested variant of urothelial carcinoma arising in a fibroepithelial polyp: Report of a case and review of literature

The nested variant of urothelial carcinoma is a rare but very important histological entity due to its deceptively bland-looking appearance and aggressive behavior. We present a case of a 30-year-old man who was found to have a solitary polypoid growth in the bladder. It was resected and found to be a fibroepithelial polyp; a rare entity in itself, harboring the above tumor. The lesion also showed a second population of scattered bizarre stromal cells. To our knowledge, this is the first instance of a nested variant of urothelial carcinoma arising in a fibroepithelial polyp. The presence of atypical stromal cells has also not been described previously.
A new heuristic approach to deal with discrete variables in optimal power flow computations

This paper proposes a new heuristic approach to deal with discrete variables in an optimal power flow (OPF). This approach relies on the first order sensitivity of the objective and inequality constraints with respect to the discrete variables. The impact of a discrete variable change on the objective and inequality constraints is aggregated into a merit function. The proposed approach searches iteratively for better discrete variable settings as long as the problem solution can be improved. We provide numerical results with the proposed approach on four test systems up to 1203 buses and for the OPF problem of active power loss minimization.
Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid

Natural killer (NK) cells are important effector cells for the first line of defense against tumor, but the mechanisms by which they recognize and kill human hepatocellular carcinoma (HCC) remains to be elucidated. Distant MHC class I homologs MICA and MICB are recently identified human ligands for NK cell activating receptor NKG2D. In our present study, MICA or MICB transcript was detected in 6 of 10 human hepatocellular carcinoma tissues, but not in the surrounding non‐cancerous tissues. Immunohistochemical analysis showed that MICA/B were expressed in the tumor cells of the cancerous tissues. Huh7 and HepG2 hepatoma cells, but not Hep3B cells, substantially expressed MICA/B on their cell surface. MICA/B expressed on hepatoma cells contributed to their NK sensitivity, because Huh7 and HepG2 were less susceptible to NK cytolysis when MAb against MICA/B was added during the cytolysis assay. Of interest is the finding that retinoic acid upregulated expression of MICA/B in Huh7 and HepG2 cells. Retinoic acid‐treated hepatoma cells induced IFNγ production from cocultured NK cells and rendered themselves more susceptible to NK cells. This was clearly dependent on upregulation of MICA/B, because both the enhanced IFNγ production and NK cytolysis were completely abolished by MAb‐mediated masking of MICA/B. These results suggest that MICA/B, expressed on a subset of human HCCs, may play an important role in their susceptibility to NK cells. Furthermore, retinoic acid can function as a modulator of MICA/B expression and thereby further activate NK cells. © 2003 Wiley‐Liss, Inc.
Learning from Experience in Software Development: A Multilevel Analysis

This study examines whether individuals, groups, and organizational units learn from experience in software development and whether this learning improves productivity. Although prior research has found the existence of learning curves in manufacturing and service industries, it is not clear whether learning curves also apply to knowledge work like software development. We evaluate the relative productivity impacts from accumulating specialized experience in a system, diversified experience in related and unrelated systems, and experience from working with others on modification requests (MRs) in a telecommunications firm, which uses an incremental software development methodology. Using multilevel modeling, we analyze extensive data archives covering more than 14 years of systems development work on a major telecommunications product dating from the beginning of its development process. Our findings reveal that the relative importance of the different types of experience differs across levels of analysis. Specialized experience has the greatest impact on productivity for MRs completed by individual developers, whereas diverse experience in related systems plays a larger role in improving productivity for MRs and system releases completed by groups and organizational units. Diverse experience in unrelated systems has the least influence on productivity at all three levels of analysis. Our findings support the existence of learning curves in software development and provide insights into when specialized or diverse experience may be more valuable.
Diagnostic imaging in patients with paragangliomas. Computed tomography, magnetic resonance and MIBG scintigraphy comparison.

OBJECTIVE We compared iodine-131 metaiodobenzylguanidine (MIBG), computed tomography (CT) and magnetic resonance (MR) imaging studies in 40 patients with suspected or proven paragangliomas. PATIENTS 21 patients were studied during the initial evaluation, while 19 were evaluated after surgery for paragangliomas. Furthermore, in 18 patients with benign (n = 10) or malignant (n = 8) tumors, MIBG uptake, MR signal intensity ratios (SIR) and CT parameters were analyzed. RESULTS In patients studied during the initial evaluation, CT and MR had a significant (p < 0.05) higher diagnostic sensitivity (100% for both) compared to MIBG (82%); conversely, MIBG showed a higher specificity (100%) compared to CT and MR (50% for both); the accuracy of MIBG (86%), CT and MR (91% for both) were similar. In patients evaluated after surgery, MIBG and MR had slightly better sensitivity (85% for both) compared to CT (77%). MIBG showed again better specificity (100%) than CT and MR (83% for both); the accuracy of MIBG, MR and CT were respectively 90%, 84% and 79%. While no significant differences were observed in MR SIR and CT findings between benign and malignant tumors, MIBG uptake was significantly higher in malignant compared to benign lesions (p < 0.03). CONCLUSIONS Our results suggest that CT and MR are particularly useful in the initial evaluation of patients with suspected paragangliomas. MIBG should be recommended during the post-surgical follow-up of such patients since recurrent, malignant or extra-adrenal disease frequently occur. Finally, while MR SIR and CT features are not able to distinguish malignant paragangliomas from benign tumors, MIBG uptake is higher in malignant lesions compared to benign tumors providing a diagnostic criterion to differentiate these lesions.