Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Medicare Medical Reviews on Ambiguous Short‐Stay Hospital Admissions

OBJECTIVE To examine the effects of Medicare's Medical Review (MR) program on short-stay inpatient hospitalization. DATA SOURCES/STUDY SETTING One Hundred percent of Medicare Part A and Part B claims and the Master Beneficiary Summary File (2007-2010). STUDY DESIGN Retrospective observational study using a difference-in-differences approach. We examined six primary intake diagnoses, we believed likely to be targeted by MR. We stratified by hospital profit structure, bed size, system membership, and inpatient admission rate to test for differential effects. The comparison group was hospital visits occurring in those MACs that had yet to implement, as well as those that did not implement during the period of interest. DATA COLLECTION None. PRINCIPAL FINDINGS Medical Review significantly reduced the likelihood of inpatient admission for patients with an intake diagnosis of "Non-Specific Chest Pain" by 1.29 percentage points (p < .001). This effect was stronger in larger hospitals (-2.03, p < .001), nonsystem hospitals (-2.54, p < .001), and those with a lower inpatient rate (-1.86, p < .001). CONCLUSIONS Short inpatient hospitalizations were emphasized by MR, and our results show that MR modestly reduced their prevalence among certain patients and certain hospitals. Future work should examine whether this resulted in adverse patient outcomes.
S100A11 promotes cell proliferation via P38/MAPK signaling pathway in intrahepatic cholangiocarcinoma

S100A11 is reported to associate with progression and poor prognosis in several tumors. We previously reported that S100A11 was highly expressed in intrahepatic cholangiocarcinoma (ICC) cells and promoted TGF‐β1‐induced EMT through SMAD2/3 signaling pathway. Here, we explored the prognostic role of S100A11 on ICC patients and preliminary molecular mechanisms how S100A11 regulated ICC cell proliferation. Our results showed that S100A11 was obviously increased in ICC tumor tissues. High expression of S100A11 was closely correlated with lymph node metastasis (LNM) and TNM stage and was an independent risk factor for patients’ overall survival (OS) and recurrence‐free survival (RFS). The nomograms comprising LNM and S100A11 achieved better predictive accuracy compared with TNM staging system for OS and RFS prediction. Silencing S100A11 significantly suppressed RBE cells and HCCC9810 cells proliferation, colony formation, and activation of P38/mitogen‐activated protein kinase (MAPK) signaling pathway in vitro and inhibited tumor growth in vivo. In contrast, the overexpression of S100A11 in RBE cells and HCCC9810 cells achieved the opposite results. S100A11‐induced proliferation was abolished after treatment with P38 inhibitor. Our findings suggest S100A11/P38/MAPK signaling pathway may be a potential therapeutic target for ICC patients.
Estrogen Therapy Worsens Cardiac Function and Remodeling and Reverses the Effects of Exercise Training After Myocardial Infarction in Ovariectomized Female Rats

There is an increase in the incidence of cardiovascular events such as myocardial infarction (MI) after menopause. However, the use of estrogen therapy (E2) remains controversial. The aim of this study was to evaluate the effects of E2, alone and combined with exercise training (ET), on cardiac function and remodeling in ovariectomized (OVX) rats after MI. Wistar female rats underwent ovariectomy, followed by MI induction were separated into five groups: S; MI; MI+ET; MI+E2; and MI+ET+E2. Fifteen days after MI or sham surgery, treadmill ET and/or estrogen therapy [17-β estradiol-3-benzoate (E2), s.c. three times/week] were initiated and maintained for 8 weeks. After the treatment and/or training period, the animals underwent cardiac hemodynamic evaluation through catheterization of the left ventricle (LV); the LV systolic and diastolic pressures (LVSP and LVEDP, respectively), maximum LV contraction and relaxation derivatives (dP/dt+ and dP/dt−), and isovolumic relaxation time (Tau) were assessed. Moreover, histological analyses of the heart (collagen and hypertrophy), cardiac oxidative stress [advanced oxidation protein products (AOPPs)], pro- and antioxidant protein expression by Western blotting and antioxidant enzyme activity in the heart were evaluated. The MI reduced the LVSP, dP/dt+ and dP/dt− but increased the LVEDP and Tau. E2 did not prevent the MI-induced changes in cardiac function, even when combined with ET. An increase in the dP/dt+ was observed in the E2 group compared with the MI group. There were no changes in collagen deposition and myocyte hypertrophy caused by the treatments. The increases in AOPP, gp91-phox, and angiotensin II type 1 receptor expression induced by MI were not reduced by E2. There were no changes in the expression of catalase caused by MI or by the treatments, although, a reduction in superoxide dismutase (SOD) expression occurred in the groups subjected to E2 treatment. Whereas there were post-MI reductions in activities of SOD and catalase enzymes, only that of SOD was prevented by ET. Therefore, we conclude that E2 therapy does not prevent the MI-induced changes in cardiac function and worsens parameters related to cardiac remodeling. Moreover, E2 reverses the positive effects of ET when used in combination, in OVX infarcted female rats.
Cox15 interacts with the cytochrome bc1 dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase

The heme a molecule is an obligatory cofactor in the terminal enzyme complex of the electron transport chain, cytochrome c oxidase. Heme a is synthesized from heme o by a multi-spanning inner membrane protein, heme a synthase (Cox15 in the yeast Saccharomyces cerevisiae). The insertion of heme a is critical for cytochrome c oxidase function and assembly, but this process has not been fully elucidated. To improve our understanding of heme a insertion into cytochrome c oxidase, here we investigated the protein–protein interactions that involve Cox15 in S. cerevisiae. In addition to observing Cox15 in homooligomeric complexes, we found that a portion of Cox15 also associates with the mitochondrial respiratory supercomplexes. When supercomplex formation was abolished, as in the case of stalled cytochrome bc1 or cytochrome c oxidase assembly, Cox15 maintained an interaction with select proteins from both respiratory complexes. In the case of stalled cytochrome bc1 assembly, Cox15 interacted with the late-assembling cytochrome c oxidase subunit, Cox13. When cytochrome c oxidase assembly was stalled, Cox15 unexpectedly maintained its interaction with the cytochrome bc1 protein, Cor1. Our results indicate that Cox15 and Cor1 continue to interact in the cytochrome bc1 dimer even in the absence of supercomplexes or when the supercomplexes are destabilized. These findings reveal that Cox15 not only associates with respiratory supercomplexes, but also interacts with the cytochrome bc1 dimer even in the absence of cytochrome c oxidase.
Nonlinear calcium ion waves along actin filaments control active hair–bundle motility

Actin filaments are highly dynamic semiflexible cellular biopolymers with diverse functions, such as cell motility. They also play the role of conduits for propagation of calcium ion waves. In this paper, we propose a new biophysical model that describes how actin filaments with their polyelectrolyte properties serve as pathways for calcium ion flows in hair cells. We show this can be utilized for the tuning of force–generating myosin motors. In this model, we unify the calcium nonlinear dynamics involved in the control of the myosin adaptation motors with mechanical displacements of hair– bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This model offers promises to fill a gap in our understanding of the role of calcium ion nonlinear dynamics in the regulation of processes in the auditory cells of the inner ear.
EGFR双突变非小细胞肺癌患者临床特征分析

背景与目的 非小细胞肺癌（non-small cell lung cancer, NSCLC）中表皮生长因子受体（epidermal growth factor receptor, EGFR）常见单突变患者临床特征研究已经得到广泛认可，女性、无或少吸烟史、腺癌患者中发生率高，经EGFR酪氨酸激酶抑制剂（tyrosine kinase inhibitors, TKIs）治疗后客观缓解率（objective response rate, ORR）和无进展生存期（progression-free survival, PFS）显著延长。 但针对EGFR双突变患者的临床特征以及对EGFR-TKIs治疗的敏感性研究尚不明确。 本研究探讨了EGFR双突变患者的临床特征及EGFR-TKIs治疗的疗效。 方法 收集2015年1月1日-2016年12月31日就诊于青岛大学附属医院接受EGFR基因检测的1, 238例原发性NSCLC患者，存在单一突变患者603例，双突变患者59例。 所有基因均统一采用ARMS-PCR技术检测。 对已明确具体基因分型的32例双突变患者进行基因分析，并随机选取60例单突变患者与59例双突变患者临床特征进行对照，同时比较晚期EGFR双突变和单突变患者对EGFR-TKIs治疗的疗效。 结果 EGFR双突变患者中以合并罕见单突变基因最为常见（30/32）。 双突变与单突变患者在性别、吸烟史、年龄、病理类型、肿瘤-淋巴结-转移（tumor-node-metastasis, TNM）分期等方面无显著性差异。 在接受EGFR-TKIs治疗的双突变患者中，ORR为36. 80%，疾病控制率（disease control rate, DCR）为68. 40%，中位PFS为6. 0个月，单突变患者中ORR为60. 00%，DCR为90. 00%，中位PFS为12. 0个月，两组PFS比较有显著性差异（P=0.003）。 结论 EGFR双突变患者的临床特征与单突变患者之间无显著性差异，双突变患者接受一代EGFR-TKIs治疗的ORR、DCR、PFS均较单突变患者低。
Flow and Immersion in Video Games: The Aftermath of a Conceptual Challenge

One of the most pleasurable aspects of video games is their ability to induce immersive experiences. However, there appears to be a tentative conceptualization of what an immersive experience is. In this short review, we specifically focus on the terms of flow and immersion, as they are the most widely used and applied definitions in the video game literature, whilst their differences remain disputable. We critically review the concepts separately and proceed with a comparison on their proposed differences. We conclude that immersion and flow do not substantially differ in current studies and that more evidence is needed to justify their separation.
Journey-to-Crime Distances of Residential Burglars in China Disentangled: Origin and Destination Effects

Research on journey-to-crime distance has revealed the importance of both the characteristics of the offender as well as those of target communities. However, the effect of the home community has so far been ignored. Besides, almost all journey-to-crime studies were done in Western societies, and little is known about how the distinct features of communities in major Chinese cities shape residential burglars’ travel patterns. To fill this gap, we apply a cross-classified multilevel regression model on data of 3763 burglary trips in ZG City, one of the bustling metropolises in China. This allows us to gain insight into how residential burglars’ journey-to-crime distances are shaped by their individual-level characteristics as well as those of their home and target communities. Results show that the characteristics of the home community have larger effects than those of target communities, while individual-level features are most influential. Older burglars travel over longer distances to commit their burglaries than the younger ones. Offenders who commit their burglaries in groups tend to travel further than solo offenders. Burglars who live in communities with a higher average rent, a denser road network and a higher percentage of local residents commit their burglaries at shorter distances. Communities with a denser road network attract burglars from a longer distance, whereas those with a higher percentage of local residents attract them from shorter by.
How Culture and Biology Interact to Shape Language and the Language Faculty

Abstract Recent work suggests that linguistic structure develops through cultural evolution, as a consequence of the repeated cycle of learning and use by which languages persist. This work has important implications for our understanding of the evolution of the cognitive basis for language; in particular, human language and the cognitive capacities underpinning it are likely to have been shaped by co‐evolutionary processes, where the cultural evolution of linguistic systems is shaped by and in turn shapes the biological evolution of the capacities underpinning language learning. I review several models of this co‐evolutionary process, which suggest that the precise relationship between evolved biases in individuals and the structure of linguistic systems depends on the extent to which cultural evolution masks or unmasks individual‐level cognitive biases from selection. I finish by discussing how these co‐evolutionary models might be extended to cases where the biases involved in learning are themselves shaped by experience, as is the case for language.
Classes of ITD Predict Outcomes in AML Patients Treated with FLT3 Inhibitors

Purpose: Recurrent internal tandem duplication (ITD) mutations are observed in various cancers including acute myeloid leukemia (AML), where ITD mutations in tyrosine kinase receptor FLT3 are associated with poor prognostic outcomes. Several FLT3 inhibitors (FLT3i) are in clinical trials for high-risk FLT3-ITD–positive AML. However, the variability of survival following FLT3i treatment suggests that the mere presence of FLT3-ITD mutations might not guarantee effective clinical response. Motivated by the heterogeneity of FLT3-ITD mutations, we investigated the effects of FLT3-ITD structural features on the response of AML patients to treatment. Experimental Design: We developed the HeatITup (HEAT diffusion for Internal Tandem dUPlication) algorithm to identify and quantitate ITD structural features including nucleotide composition. Using HeatITup, we studied the impact of ITD structural features on the clinical response to FLT3i and induction chemotherapy in FLT3-ITD–positive AML patients. Results: HeatITup accurately identifies and classifies ITDs into newly defined categories of “typical” or “atypical” based on their nucleotide composition. A typical ITD's insert sequence completely matches the wild-type FLT3, whereas an atypical ITD's insert contains nucleotides exogenous to the wild-type FLT3. Our analysis shows marked divergence between typical and atypical ITD mutation features. Furthermore, our data suggest that AML patients carrying typical FLT3-ITDs benefited significantly more from both FLT3i and induction chemotherapy treatments than patients with atypical FLT3-ITDs. Conclusions: These results underscore the importance of structural discernment of complex somatic mutations such as ITDs in progressing toward personalized treatment of AML patients, and enable researchers and clinicians to unravel ITD complexity using the provided software. See related commentary by Gallipoli and Huntly, p. 460
Breaking the nanoparticle loading-dispersion dichotomy in polymer nanocomposites with the art of croissant-making

The Chordal Vertex Deletion (ChVD) problem asks to delete a minimum number of vertices from an input graph to obtain a chordal graph. In this paper we develop a polynomial kernel for ChVD under the parameterization by the solution size. Using a new Erd\H os-P\' osa-type packing/covering duality for holes in nearly chordal graphs, we present a polynomial-time algorithm that reduces any instance (G, k) of ChVD to an equivalent instance with poly(k) vertices. The existence of a polynomial kernel answers an open problem posed by Marx in 2006 [D. Marx, ``Chordal Deletion Is Fixed-Parameter Tractable,"" in Graph-Theoretic Concepts in Computer Science, Lecture Notes in Comput. Sci. 4271, Springer, 2006, pp. 37--48]. To obtain the kernelization, we develop the first poly(opt)-approximation algorithm for ChVD, which is of independent interest. In polynomial time, it either decides that G has no chordal deletion set of size k, or outputs a solution of size \scrO (k4 log k).
Zero-shot User Intent Detection via Capsule Neural Networks

User intent detection plays a critical role in question-answering and dialog systems. Most previous works treat intent detection as a classification problem where utterances are labeled with predefined intents. However, it is labor-intensive and time-consuming to label users’ utterances as intents are diversely expressed and novel intents will continually be involved. Instead, we study the zero-shot intent detection problem, which aims to detect emerging user intents where no labeled utterances are currently available. We propose two capsule-based architectures: IntentCapsNet that extracts semantic features from utterances and aggregates them to discriminate existing intents, and IntentCapsNet-ZSL which gives IntentCapsNet the zero-shot learning ability to discriminate emerging intents via knowledge transfer from existing intents. Experiments on two real-world datasets show that our model not only can better discriminate diversely expressed existing intents, but is also able to discriminate emerging intents when no labeled utterances are available.
OCNet: Object Context Network for Scene Parsing

In this paper, we address the semantic segmentation task with a new context aggregation scheme named \emph{object context}, which focuses on enhancing the role of object information. Motivated by the fact that the category of each pixel is inherited from the object it belongs to, we define the object context for each pixel as the set of pixels that belong to the same category as the given pixel in the image. We use a binary relation matrix to represent the relationship between all pixels, where the value one indicates the two selected pixels belong to the same category and zero otherwise. We propose to use a dense relation matrix to serve as a surrogate for the binary relation matrix. The dense relation matrix is capable to emphasize the contribution of object information as the relation scores tend to be larger on the object pixels than the other pixels. Considering that the dense relation matrix estimation requires quadratic computation overhead and memory consumption w.r. t. the input size, we propose an efficient interlaced sparse self-attention scheme to model the dense relations between any two of all pixels via the combination of two sparse relation matrices. To capture richer context information, we further combine our interlaced sparse self-attention scheme with the conventional multi-scale context schemes including pyramid pooling~\citep{zhao2017pyramid} and atrous spatial pyramid pooling~\citep{chen2018deeplab}. We empirically show the advantages of our approach with competitive performances on five challenging benchmarks including: Cityscapes, ADE20K, LIP, PASCAL-Context and COCO-Stuff
Predictors of dyspnea in patients with advanced cancer.

BACKGROUND More than 70% of patients with advanced cancer experience dyspnea. Dyspnea is predictive of shorter survival and interferes with quality of life (QOL). The present study aimed to identify predictors of the presence and severity of dyspnea in advanced cancer patients. METHODS A prospective database collected from patients attending a palliative radiotherapy clinic was analyzed for patient demographics, Edmonton Symptom Assessment System (ESAS) scores, Patient-Reported Functional Status (PRFS), history of smoking and respiratory conditions, pulse oximetry readings, and primary cancer site. Using the ESAS shortness of breath item, dyspnea was classified as mild [1-3], moderate [4-6] or severe [7-10]. Logistic regression analysis and generalized estimating equations (GEEs) were used to identify predictors of the severity of dyspnea and presence of moderate/severe dyspnea (ESAS ≥4) at patients' first visit and over time, respectively. RESULTS A total of 252 patients with dyspnea data were included (median age 71.3 years, 61.5% male, 44.4% had dyspnea) in a demographic analysis. Multivariable analysis showed liver metastases (P=0.01, OR =2.04), a history of respiratory conditions (P=0.03, OR =2.09) and PRFS ≥3 (P=0.03, OR =1.75) were predictive of the severity of dyspnea at the first visit. Analyzed over time, liver metastases (P=0.02, OR =1.80), lymph node metastases (P=0.02, OR =1.79), a history of respiratory conditions (P=0.006, OR =2.50) and pulse oximetry <90 (P=0.003, OR =3.32) were predictive of greater severity of dyspnea symptoms. Patients with multiple radiation treatments in the thorax region were less likely to have severe dyspnea symptoms over time (P=0.01, OR =0.32). Lung metastases (P=0.04, OR =2.03), a history of respiratory conditions (P=0.01, OR =2.60) and PRFS ≥3 (P=0.009, OR =2.30) were predictive of moderate/severe dyspnea at the first visit. Over time, lymph node metastases (P=0.003, OR =2.51), a history of respiratory conditions (P=0.04, OR =2.37) and pulse oximetry <90 (P=0.0004, OR =5.15) were predictive of moderate/severe dyspnea. CONCLUSIONS Liver, lung and lymph node metastases, a history of respiratory conditions, pulse oximetry <90 and PRFS ≥3 were predictive of the severity of dyspnea and moderate/severe dyspnea. Physicians should be aware of predictive factors that could lead to dyspnea to promote early intervention for improved patient care and the creation of screening tools for clinical practice.
Comparative pharmacokinetics of danofloxacin in healthy and Pasteurella multocida infected ducks

Pasteurella multocida (P. multocida) infection causes substantial economic loss in the duck industry. Danofloxacin, a fluoroquinolone solely used in animals, shows good antibacterial activity against P. multocida. In this study, the in vitro pharmacodynamics of danofloxacin against P. multocida was studied. The serum and lung tissue pharmacokinetics of danofloxacin were studied in healthy and P. multocida infected ducks following oral administration of a single dose of 5 mg/kg body weight (b.w.). The MIC, MBC and MPC of danofloxacin against P. multocida (C48-1 ) were 0.25, 1 and 3.2 μg/ml, respectively. The Cmax was 0.34 μg/ml, attained at 2.03 hr in healthy ducks, and was 0.35 μg/ml, attained at 2.87 hr in diseased ducks. Compared to the serum pharmacokinetics of danofloxacin in healthy ducks, the absorption rate and extent were similar in healthy and diseased animals. In contrast, the elimination rate was slower, with an elimination half-life (T1/2β ) of 13.17 and 16.18 hr for healthy and infected animals, respectively; the AUCs in the two groups were 5.70 and 7.68 μg hr/ml, respectively, which means the total amount of drug in the circulation was increased in the infected ducks. The maximum concentration in lung tissues between healthy and infected animals was not significantly different (8.96 vs. 8.93 μg/g). However, the Tmax in healthy ducks was longer than that in infected ducks (4 hr vs. 1.75 hr), which means that the distribution rate of danofloxacin was slower in healthy ducks. The concentration of danofloxacin in lung tissues was approximately 24-fold higher than that in the serum. In the serum pharmacokinetic profiles, the ƒAUC0-24 hr /MIC was 18.19 in healthy ducks and was 25.04 in P. multocida infected ducks at the clinical recommended dose, which is far from the PK/PD target (125 hr) of fluoroquinolones. Danofloxacin, at a dose of 5 mg/kg b.w. , seems to be insufficient for ducks infected with P. multocida, with an MIC equal to 0.25 μg/ml.