Miracle-dz/UniFAR-FTUs huggingface dataset:
The Plexin PLX-2 and the Ephrin EFN-4 Have Distinct Roles in MAB-20/Semaphorin 2A Signaling in Caenorhabditis elegans Morphogenesis

Semaphorins are extracellular proteins that regulate axon guidance and morphogenesis by interacting with a variety of cell surface receptors. Most semaphorins interact with plexin-containing receptor complexes, although some interact with non-plexin receptors. Class 2 semaphorins are secreted molecules that control axon guidance and epidermal morphogenesis in Drosophila and Caenorhabditis elegans. We show that the C. elegans class 2 semaphorin MAB-20 binds the plexin PLX-2. plx-2 mutations enhance the phenotypes of hypomorphic mab-20 alleles but not those of mab-20 null alleles, indicating that plx-2 and mab-20 act in a common pathway. Both mab-20 and plx-2 mutations affect epidermal morphogenesis during embryonic and in postembryonic development. In both contexts, plx-2 null mutant phenotypes are much less severe than mab-20 null phenotypes, indicating that PLX-2 is not essential for MAB-20 signaling. Mutations in the ephrin efn-4 do not synergize with mab-20, indicating that EFN-4 may act in MAB-20 signaling. EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting.
Social networks and daily activities of street youth in Belo Horizonte, Brazil

Social networks and daily activities of children and adolescents living and/or working on the streets of a large Brazilian city were examined. Drawing on data collected through structured surveys, in-depth interviews, focus group discussions, and field observations, we described street youths' family situation, social resources, institutional experiences, survival activities, and problem behaviors and investigated differences attributable to age, gender, and living situation (at home or on the street). Youngsters who lived at home and worked on the street appeared to be experiencing orderly development despite their impoverished circumstances. Youngsters who lived on the street showed hallmarks of psychological and physical risk, including parental loss, diminished social support, substance abuse, and early onset of sexual activity. Possible implications of these contextual differences for development are discussed, and directions for future research are suggested.
Capacity Investment Under Postponement Strategies, Market Competition, and Demand Uncertainty

We consider duopoly models where firms make decisions on capacity, production, and price under demand uncertainty. Capacity and price decisions are made, respectively, ex ante and ex post demand realizations. The interplay between the timings of demand realization and production decision endows firms with different capabilities. Flexible firms can postpone production decisions until the actual demand curve is observed, but inflexible firms cannot. Under general demand structures and cost functions, we characterize the equilibrium for a symmetric duopoly and establish the strategic equivalence of price and quantity competitions when firms are flexible. We investigate the stochastic order properties of capacity and profit and show that they both increase for a flexible firm when the market is more volatile. We find that flexibility allows a firm to increase investment in capacity and earn a higher profit while benefiting customers by keeping the price in a narrower range; strategic equivalence implies that these properties are robust to market conjectures. We also show that flexibility plays an important role in mitigating the destructive effect of competition when the demand shock is additive; the destructive effect is nonexistent for firms facing multiplicative demand shock. When flexibility decision is endogenous, a firm's strategic flexibility choice depends on the cost of technology as well as the nature of demand shock. In particular, faced with a multiplicative demand shock, firms always choose to be inflexible, whereas all the possible equilibria are observed under additive demand shocks.
A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator.

A stochastic clonal growth model for describing quantitative changes in size and number of putative preneoplastic lesions was modified to analyze the time-course information of cell proliferation and glutathione S-transferase pi (GST-P) foci within a medium-term bioassay. The study used F344 rats and a single initiating event using diethylnitrosamine (200 mg/kg ip) at Week 0. After a 2-week recovery period, chemical treatment began by gavage administration of pentachlorobenzene (PeCB; 100 micromol/kg/day, 7 days/week) in a corn oil vehicle and continued for 6 weeks. One week after beginning gavage dosing, a two-thirds partial hepatectomy was performed and the animals were serially euthanized at 48, 120, 168, 624, and 840 h postsurgery, which corresponds to 216, 288, 336, 792, and 1008 h following the beginning of PeCB treatment, respectively. For analysis, two types of models were evaluated for describing the time-course changes in GST-P foci. First, a sequential model describing the transformation of normal cells into a homogenous initiated cell population (i.e., one-cell model). Second, a two-cell model that describes a heterogeneous foci population by splitting the initiated cell population into two distinct types. In our study, the one-cell model was unable to adequately represent the time-course data for changes in both size and number of foci. In contrast, the two-cell model, which was parameterized to describe a negative selection mechanism, produced adequate simulations of both the size and number of foci. This model-based analysis suggested that the differences between PeCB-treated and untreated animals were primarily in parameters involving the rates of cell death.
Affordances of the Care Environment for People with Dementia—An Assessment Study

Background: Evidence on the importance of the physical environment for the well-being of people with dementia has been growing steadily. Objective: This article aims to (1) introduce an assessment tool for evaluating the physical care environment for people with dementia; (2) describe the method's initial results and the subsequent feedback provided to the 10 care units; and (3) describe the follow-up results 1 year later. The goal has been to provide care workers and managers with information that affects the well-being of people with dementia and to provide this information on the care environment in the context of their own work environment. Methods: The assessment was part of a randomized controlled intervention using nonpharmaceutical methods to decrease behavioral and psychological symptoms of people with dementia. During the half-day visits, photographs and field notes were taken, and a final assessment was carried out via the Residential Care Environment Assessment (RCEA) tool developed at the beginning of the study and based on affordance theory. Follow-up data were gathered after 12 months. Results: There were several possibilities for improvements in the provision of residential care in a person-centered environment. Improvements were needed mostly in comfort and in providing opportunities for engagement, activity, and expression of identity. However, in practice, it was difficult to achieve the improvements even with an intensive intervention study. Conclusions: The authors conclude that the physical care environment involves a complex set of issues and stakeholders in which the impetus to fulfill responsibilities to carry out improvements can easily fall away.
Influence of Contraction Mismatch and Cooling Rate on Flexural Failure of PFM Systems

The interactive influence of cooling rate and the sign and magnitude of thermal contraction difference between metals and ceramic veneers on bond strength have not been extensively analyzed, although numerous bond-test studies have been reported during the past two decades. A previous analytical study of residual incompatibility stress in bond-test specimens indicated that bond strength values may be of relatively little value if the residual stress state of the metal-ceramic specimens is not considered. The objective of this study was to determine the influence of cooling rate and contraction mismatch on the flexural failure resistance of metal opaque-porcelain strips. Specimens were subjected to four-point loading in an Instron testing machine until crack initiation occurred at the metal-ceramic interface. The residual stress states in the ceramic region were estimated from finite element stress analyses of the bond-test specimens by use of dilatometry data obtained at the cooling rate of 3°Clmin. The total stress induced from the residual stress and the applied flexural load was also determined for these specimens. Statistical analyses of the experimental data revealed that the slowly cooled specimens exhibited a significantly lower (p < 0.05) flexural strength compared with rapidly cooled specimens. Regardless of the cooling technique, metal-ceramic specimens with a negative thermal contraction difference (αm - αp < 0) failed at significantly lower (p < 0.05) flexural loads than did specimens with a positive thermal contraction difference.
Identification of novel proteins binding the AU-rich element of α-prothymosin mRNA through the selection of open reading frames (RIDome)

We describe here a platform for high-throughput protein expression and interaction analysis aimed at identifying the RNA-interacting domainome. This approach combines the selection of a phage library displaying “filtered” open reading frames with next-generation DNA sequencing. The method was validated using an RNA bait corresponding to the AU-rich element of α-prothymosin, an RNA motif that promotes mRNA stability and translation through its interaction with the RNA-binding protein ELAVL1. With this strategy, we not only confirmed known RNA-binding proteins that specifically interact with the target RNA (such as ELAVL1/HuR and RBM38) but also identified proteins not previously known to be ARE-binding (R3HDM2 and RALY). We propose this technology as a novel approach for studying the RNA-binding proteome.
Momentum and Information Uncertainty

This study shows that uncertainty about information does not strengthen momentum. If the behavioral models hold, and if uncertainty about information causes high-volatility momentum strategies to outperform low-volatility strategies, then this relation must hold on a relative level. Momentum must be stronger among those stocks that show an increased uncertainty about the momentum formation period information, than among stocks where the uncertainty about the formation period has been relatively low. The results show a larger investor underreaction to positive, relatively reliable, information than to positive and relatively uncertain information.
Stimulus‐specific effects of noradrenaline in auditory cortex: implications for the discrimination of communication sounds

Many studies have described the action of Noradrenaline (NA) on the properties of cortical receptive fields, but none has assessed how NA affects the discrimination abilities of cortical cells between natural stimuli. In the present study, we compared the consequences of NA topical application on spectro‐temporal receptive fields (STRFs) and responses to communication sounds in the primary auditory cortex. NA application reduced the STRFs (an effect replicated by the alpha1 agonist Phenylephrine) but did not change, on average, the responses to communication sounds. For cells exhibiting increased evoked responses during NA application, the discrimination abilities were enhanced as quantified by Mutual Information. The changes induced by NA on parameters extracted from the STRFs and from responses to communication sounds were not related.
WOMEN BEHIND BARS: COULD NEUROBIOLOGICAL CORRELATES OF PAST PHYSICAL AND SEXUAL ABUSE CONTRIBUTE TO CRIMINAL BEHAVIOR?

Trauma, especially physical and sexual abuse inflicted by others, is often part of the personal histories of female prison inmates. These traumatic events have also been associated with neuropsychiatric conditions commonly found in female inmate populations. The purpose of this article is to provide a review of the literature and research findings about physical and sexual abuse perpetrated against female prison inmates predating their crimes, the neurobiological correlates, and related factors that could have contributed to criminal behaviors. This information is critical for abuse and crime prevention and rehabilitation of female victims who have become criminal offenders.
Roles of Individual N-Glycans for ATP Potency and Expression of the Rat P2X1 Receptor*

P2X1 receptor subunits assemble in the ER of Xenopus oocytes to homotrimers that appear as ATP-gated cation channels at the cell surface. Here we address the extent to which N-glycosylation contributes to assembly, surface appearance, and ligand recognition of P2X1receptors. SDS-polyacrylamide gel electrophoresis (PAGE) analysis of glycan minus mutants carrying Gln instead of Asn at five individual NXT/S sequons reveals that Asn284 remains unused because of a proline in the +4 position. The four other sites (Asn153, Asn184, Asn210, and Asn300) carryN-glycans, but solely Asn300 located only eight residues upstream of the predicted reentry loop of P2X1acquires complex-type carbohydrates. Like parent P2X1, glycan minus mutants migrate as homotrimers when resolved by blue native PAGE. Recording of ATP-gated currents reveals that elimination of Asn153 or Asn210 diminishes or increases functional expression levels, respectively. In addition, elimination of Asn210 causes a 3-fold reduction of the potency for ATP. If three or all four N-glycosylation sites are simultaneously eliminated, formation of P2X1 receptors is severely impaired or abolished, respectively. We conclude that at least oneN-glycan per subunit of either position is absolutely required for the formation of P2X1 receptors and that individual N-glycans possess marked positional effects on expression levels (Asn154, Asn210) and ATP potency (Asn210).
Spinal Mobility and Trunk Muscle Strength in 15‐Year-Old Schoolchildren With and Without Low‐Back Pain

From a population of 1,503 schoolchildren, 38 15-year-old children suffering from low-back pain and 38 asymptomatic controls were selected for testing of spinal mobility and trunk muscle strength. The asymptomatic controls were matched by age, sex, and school class. In the group with recurrent or continual low-back pain (17 boys and 21 girls), the boys were over 4 cm taller than those in the control group. In both sexes sagittal mobility was decreased in lumbar extension and straight leg raising, and increased in lumbar flexion. Endurance strength in the abdominal and back muscles was decreased compared to the control pupils, who reported no back pain at all in the questionnaire collected 1 year before the testing procedure. The pupils reporting sciatica (n = 7) at some time, in addition to recurrent low-back pain, had decreased lumbar flexion and side bending compared to those with recurrent low-back pain (n = 31) without sciatica. The results of the study indicated that in this growing-age population there was a subgroup with recurrent low-back pain having a different spinal mobility pattern as well as decreased trunk muscle strength.
Gastrointestinal bleeding associated with low-dose aspirin use: relevance and management in clinical practice

Importance of the field: Aspirin reduces the risk of cardiovascular events, but it is well documented that it can also damage the gastrointestinal (GI) tract. However, the reasons why some people develop serious lesions, whereas most only have minor, clinically irrelevant lesions are poorly understood. Areas covered in this review: A number of risk factors can be used to determine which patients are more likely to develop aspirin-associated GI bleeding, mainly in the upper GI tract; these include a previous GI ulcer, ulcer complications, dyspepsia, and concomitant drug therapy with non-steroidal anti-inflammatory drugs (NSAIDs) or clopidogrel. The possible role of Helicobacter pylori infection is also considered. What the reader will gain: Aspirin-induced GI damage can be reduced, and a number of strategies can be implemented to shift the risk–benefit ratio in favour of aspirin. Proton pump inhibitors are more effective than H2-receptor antagonists in preventing dyspeptic symptoms, peptic ulcers and bleeding ulcers in aspirin users. Although H. pylori infection may be a risk factor of aspirin-induced ulcer bleeding, the role of its eradication in the prevention of this outcome requires further investigation. Take home message: The individual assessment of the benefits and risks with aspirin, based on the underlying GI and cardiovascular risk factors, is the key to successful therapy. Understanding the effect of aspirin on colorectal cancer can also alter the risk–benefit ratio in at-risk aspirin users.
Instrument or Structure? Investigating the Potential Uses of Twitter in Kuwait

Instrument or Structure? Investigating the Potential Uses of Twitter in Kuwait Geoff Martin Advisor: University of Guelph, 2013 Dr. Janine Clark This thesis examines if and how Twitter can be used to organize protests by activists. Theoretically, it addresses several debates about Internet technology in approaches to Social Movement Theory, Network Theory, and Digital Politics Theory and synthesizes them to create an analytical framework to address Internet technologies effects, or lack thereof, on civil society. Through a case study examining protests in Kuwait empirical results indicate that Twitter does not have a significant impact on collective action efforts as it is not used to connect activists or create a forum for dialogue. Instead it is used to promote slogans and provide on-the-ground-reports of events, which do not have significant effects on organizing collective action. The reason for its relative insignificance is largely due to political, social and economic obstacles that polarize and fragment online collective action efforts.
Regional Differences in the Determinants of Cash Holdings

This study investigates the existence of differences in the influence of firm characteristics on the level of cash across geographic regions. I tackle this question by undertaking a meta-regression analysis and find that geographic regions affect the association between firm characteristics and the level of cash. The influence of cash-determinants is similar in North America and Europe but different in Asia. The cause of this difference remains unclear. Results indicate that Asian firms are potentially affected by country-level agency concerns or a lack of financing alternatives. Regional differences persist after controlling for firm-level information asymmetries, country characteristics, and temporal trends.
Attachment and psychopathology in a community sample

Abstract The Structured Clinical Interview for DSM-III-R (SCID-I) and the Adult Attachment Interview (AAI) were administered to 60 women participating in a study (n = 226) of mother – child interaction. These women were not referred to the study for psychiatric care. The 60 women interviewed with the AAI were selected from the first 190 women who completed the SCID-I, so that 30 received a diagnosis and 30 did not. Analyses indicated that psychopathology diagnoses were associated significantly with mental representations of attachment classified in the AAI. The non-autonomous groups had increased likelihood of SCID diagnosis, compared to the autonomous group. While 32% of women with autonomous AAI transcripts received SCID diagnoses, 63% of women with Dismissing, 100% of woman with Preoccupied, and 65% of women with Unresolved transcripts received diagnoses. Secondary analyses indicated that Dismissing classifications were associated with Axis I diagnoses and Preoccupied classifications with affective disorders. Of note was that among women with Unresolved classifications, underlying secure attachment was associated with low risk of psychopathology, while underlying anxious attachment was associated with elevated risk of diagnosis. These findings support the premise from attachment theory that early relationships affect patterns of interpersonal expectations and behavior and affect regulation.
Antiplatelet therapy and carotid plaque hemorrhage and its clinical implications.

UNLABELLED One hundred and fifty-four carotid endarterectomy plaques were studied to determine the correlation of multiple intraplaque hemorrhages to (1) carotid symptoms, (2) the percentage of carotid stenosis, and (3) the preoperative antiplatelet therapy. The plaques were evaluated histopathologically for the presence of multiple hemorrhages. The data were analyzed using the chi 2 test. Multiple hemorrhages were noted in 60.4% and single or not hemorrhage in 39.6% of patients with hemispheric symptoms. In patients with nonhemispheric symptoms, 9.4% had multiple hemorrhages and 90.6% has single or no hemorrhages; 89.4% plaques with multiple hemorrhages had stenosis greater than 75% in contrast to 37.5% in plaques with single or no hemorrhage; and 62.5% with single or no hemorrhage had stenosis of less than 75% (p less than 0.001). In patients receiving antiplatelet therapy, 80.1% of plaques with multiple hemorrhages were removed, in contrast to 19.7% from patients not receiving antiplatelets (p less than 0.001). IN CONCLUSION Multiple intraplaque hemorrhages were seen more often in patients with hemispheric symptoms and are associated with more critical carotid stenosis. Preoperative antiplatelet therapy increases the incidence of repeated plaque hemorrhages; therefore, we question the validity of this therapy in certain patients with carotid disease.
A Novel Wideband FMM for Fast Integral Equation Solution of Multiscale Problems in Electromagnetics

In this paper, we propose a novel scheme to accelerate integral equation solvers when applied to multiscale problems. These class of problems exhibit multiple length/frequency scales and arise when analyzing scattering/radiation from realistic structures where dense discretization is necessary to accurately capture geometric features. Solutions to the discretized integral equations due to these structures is challenging, due to their high computational cost and ill-conditioning of the resulting matrix system. The focus of this paper is on ameliorating the computational cost. Our approach will rely on exploiting the recently developed accelerated Cartesian expansion (ACE) algorithm to arrive at a method that is stable and efficient at low frequencies. These will then be integrated with the well known fast multipole method, thus forming a scheme that is wideband. Rigorous convergence estimates of this method are derived, and convergence and efficiency of the overall fast method is demonstrated. These are then integrated into an existing integral equation solver, whose efficiency is demonstrated for some practical problems.