Miracle-dz/UniFAR-FTUs huggingface dataset:
Livability in dense residential neighbourhoods of Dhaka

Abstract Prime cities in developing countries, like Dhaka experience haphazard and intense horizontal densification. The livability of dense neighbourhoods needs to be investigated, particularly, the role of housing and planning in mitigating density problems and capitalizing the advantages of high-density living. This article argues that housing form and planned community facilities giving respect to socio-cultural practices can significantly influence Dhaka’s livability. Also, a wider definition of housing should be adopted to facilitate improvements in livability. As well, an integrated approach of residential planning is important in intensified housing development projects or planning for dense areas, encompassing housing standards, community facilities, public transport, open space provision and socio-cultural habits. This paper recommends the Bangladeshi Government to ensure enforcement of residential plans, to establish density zones in Dhaka’s main urban areas to guide spatial and transport development and neighbourhood facility provision, and to give greater respect for cultural practices in neighbourhood planning.
The credit channels of monetary policy transmission: implications on output and employment in Nigeria

There has been an increasing trend in the unemployment rate despite the growth rate witnessed. Monetary policy is presumed as one of the ways to improve the situation. Likewise, the relationship between monetary policy and employment has generated controversial debates in the literature. Though its connection has been extensively studied, however, the implications of monetary policy in respect to time frame perspectives on employment and output have not been widely addressed in the literature. This study provides evidence on shock effects, long and short-run impacts of monetary policy transmission through the credit channels on output and employment in Nigeria within the period of 1981 to 2016 using the Structural Vector Autoregression and Autoregressive distributed lags (ARDL). Evidence from the forecast error shock showed that variations in monetary policy indicators affect output more than employment in the first two periods; however, it affects employment more afterwards. The ARDL results show no evidence of co-integration when output is used as the dependent variable; conversely, cointegration exists when employment is used as the dependent variable. The monetary policy indicators: money supply, bank deposit liability and interest rate are statistically and economically significant with employment in the long run. In the short run, money supply and interest rate are economically and statistically significant. The findings revealed that the Nigerian government can maximize the long-run benefits of monetary policy through the credit channels on employment. Hence, there is a need for policymakers to look beyond short-run gain and promote long-run employment via monetary policy among others.
Interspersed Distribution of Selectivity to Kinematic Stimulus Features in Supragranular Layers of Mouse Barrel Cortex

Neurons in the primary sensory regions of neocortex have heterogeneous response properties. The spatial arrangement of neurons with particular response properties is a key aspect of population representations and can shed light on how local circuits are wired. Here, we investigated how neurons with sensitivity to different kinematic features of whisker stimuli are distributed across local circuits in supragranular layers of the barrel cortex. Using 2-photon calcium population imaging in anesthetized mice, we found that nearby neurons represent diverse kinematic features, providing a rich population representation at the local scale. Neurons interspersed in space therefore responded differently to a common stimulus kinematic feature. Conversely, neurons with similar feature selectivity were located no closer to each other than predicted by a random distribution null hypothesis. This finding relied on defining a null hypothesis that was specific for testing the spatial distribution of tuning across neurons. We also measured how neurons sensitive to specific features were distributed relative to barrel boundaries, and found no systematic organization. Our results are compatible with randomly distributed selectivity to kinematic features, with no systematic ordering superimposed upon the whisker map.
Analysis of the problem of intervention control in the economy on the basis of solving the problem of tuning

The paper proposes a new stochastic intervention control model conducted in various commodity and stock markets. The essence of the phenomenon of intervention is described in accordance with current economic theory. A review of papers on intervention research has been made. A general construction of the stochastic intervention model was developed as a Markov process with discrete time, controlled at the time it hits the boundary of a given subset of a set of states. Thus, the problem of optimal control of interventions is reduced to a theoretical problem of control by the specified process or the problem of tuning. A general solution of the tuning problem for a model with discrete time is obtained. It is proved that the optimal control in such a problem is deterministic and is determined by the global maximum point of the function of two discrete variables, for which an explicit analytical representation is obtained. It is noted that the solution of the stochastic tuning problem can be used as a basis for solving control problems of various technical systems in which there is a need to maintain some main parameter in a given set of its values.
Determination of phenolic compounds, flavonoids, and antioxidant activities in water extracts of Thai red and white rice cultivars.

BACKGROUND Free radical-induced oxidative stress damages cellular components leading to many human diseases. Plant-derived antioxidant compounds have become a profitable alternative to prevent oxidative stress in cells. OBJECTIVE To determine and compare total phenolic and flavonoid contents as well as antioxidant activity using both chemical and cell assays in the water extracts of brown rice and rice bran from two Thai rice cultivars: Sangyod, a red pigmented rice typically grown in Southern Thailand and Dawk Mali 105, a commercial white-colored rice. MATERIAL AND METHOD All the rice water extracts were analyzed for their total phenolic and flavonoid contents using the colorimetric assays, as well as for their antioxidant activity through two chemical assays: DPPH radical-scavenging and inhibition of lipid peroxidation assays, as well as through cell-based assays: scavenging capacity of intracellular ROS in HL60 cells using the fluorescent DCF and the NBT reduction. RESULTS The two chemical assays detected free radical scavenging and free radical chain breaking activities in all the rice extracts with EC50 values ranging from 26 to 357 microg/ml. Moreover, the cell-based assays detected ROS scavenging activities of these extracts with EC50 values in the range of 0.6-5 mg/ml. All these assays indicated that the water extracts of Sangyod exerted significantly higher antioxidant activity than those of Dawk Mali 105, which exhibited only moderate to low activity. Furthermore, high levels of antioxidant activity of the water extracts of Sangyod were closely correlated to their flavonoid and phenolic contents, which were approximately 2.5 and 3 times higher, respectively, than those of Dawk Mali 105. CONCLUSION These findings suggest that water extracts from colored brown rice or colored rice bran can be promising sources of potential natural antioxidants.
Academic Engagement and Intention to Drop Out: Levers for Sustainability in Higher Education

The present paper analyses the relevance of academic engagement in the process of students dropping out of school. Previous studies have consistently shown strong associations between engagement and students’ achievement outcomes. The increased attention given to academic engagement in recent years is also visible in the efforts of stakeholders in higher education to increase engagement and, consequently, to reduce dropout. The relationships between engagement and dropout rates are somewhat fuzzier, vigor, dedication, and absorption vary inconsistently in students at risk. Using a correlation research design, we tested several dimensions of academic engagement as predictors of early dropout intentions on a sample of first-year students (N = 1063). The results showed that psychological academic engagement of students is a significant predictor of early dropout intentions. Differences in academic engagement given by family background and academic context were also tested. The implications of the results are discussed in the light of possible interventions for increasing academic engagement of university students. Also, suggestions for including employers in academic engagement and dropout interventions are given.
High nucleotide substitution error frequencies in clonal pools of vesicular stomatitis virus

Nucleotide substitution error frequencies were determined for several specific guanine base positions in the genomes of cloned vesicular stomatitis virus populations. Predetermined sites were examined in coding regions for the N, M, and L proteins and at a site in the genome 5'-end regulatory region. Misincorporation frequencies were estimated to be on the order of 10(-3) to 10(-4) at all positions analyzed. Isolates taken from virus populations after disruption of equilibrium conditions displayed replicase fidelity similar to that of cloned wild-type vesicular stomatitis virus. These mutation frequencies apply to all virus genomes present, including viruses rendered nonviable by lethal mutations. At one selected site in the N gene, two of three G----N base substitutions generated lethal nonsense mutations, yet their frequency was also very high. Biological implications for rapid virus evolution are discussed.
A comparative study of low-fluence 1,064nm Q-Switched Nd:YAG laser with or without chemical peeling using Jessner's solution in melasma patients

Abstract Background: Although low-fluence 1,064-nm Q-switched Nd:YAG laser (QSNYL) is widely used for the treatment of melasma, multiple treatments are necessary for clinical improvement. Superficial chemical peeling using Jessner's solution has been used for treatment of melasma conventionally. Objectives: To evaluate the additional therapeutic effect and adverse effects of Jessner's peel when combined with 1,064 nm QSNYL for melasma patients in a double-blind, placebo-controlled design. Methods: Total of 52 patients were included. Patients who received 10 sessions of 1,064 nm QSNYL plus chemical peeling with placebo (Group A) in a two-week intervals and those who received 10 sessions of 1,064 nm QSNYL plus chemical peeling with Jessner's solution (Group B) in a 2-week intervals were analyzed. Responses were evaluated using the Melasma Area and Severity Index (MASI) score, physician's global assessment (PGA) and subjective self-assessment. Results: At 8 weeks, the mean MASI score decreased from 8.68 ± 4.06 to 8.60 ± 3.88 in Group A and from 8.98 ± 3.72 to 7.13 ± 2.57 in Group B, showing a significant difference (p < 0.001). But at 20 weeks, there was no significant difference on reduction of MASI, self-assessment, and PGA between the two groups. No serious adverse effects were reported with the additional Jessner's peeling. Conclusion: This study suggests Jessner's peel is a safe and effective method in the early course of treatment for melasma, when combined with low-fluence 1,064-nm QSNYL.
Essential feedback on first prototypes of smart mobile walker and upper extremity assistive robot

Innovative assistive rehabilitation robots are being developed with the participation of user candidates and clinical experts during the entire robot-development process. The purpose of this study is to obtain feedback from users and clinical experts during a demonstration of the first prototype of both the smart mobile walker and the upper extremity assistive robot. In the case of the smart mobile walker, safety is crucial for all users. The system's weight is another important factor for users who are elderly or fragile. In addition, people with spinal cord injuries require ease of accessibility between a wheelchair and the smart mobile walker. For the upper extremity assistive robot with spinal cord injuries require assistance to use their fine motor skills, i.e., finger movements. Different fine motor skills are assisted depending on the disability of the user. Overall, the walker needs to have the capability of being customizable while retaining its safety. In addition, the upper extremity assistive robot requires a suitable handle, a pleasant appearance, and a grasping function. This feedback will contribute to the development of a pragmatic rehabilitation robot.
Molecular Cloning and Expression of Serum Calcium- decreasing Factor (Caldecrin) (*)

We previously reported on the purification of a serum calcium-decreasing factor, referred to as caldecrin, from porcine pancreas, that is thought to be a serine protease (Tomomura, A., Fukushige, T., Noda, T., Noikura, T., and Saheki, T.(1992) FEBS Lett. 301, 277-281). In the present study, we purified caldecrin from rat pancreas and determined its primary structure by cDNA cloning. The predicted caldecrin protein is presumed to be synthesized as a preproenzyme of 268 amino acids with a signal peptide of 16 amino acids and an activation peptide of 13 amino acids, and is, with the exception of a central region, almost identical to the reported rat pancreatic elastase IV sequence. The caldecrin gene is selectively expressed in the pancreas, as judged by Northern blot analysis. After expression in BMT-10 cells, immunoreactive caldecrin was found in the culture supernatant, and it inhibited the parathyroid hormone-stimulated Ca release from cultured fetal long bones. Catalytic site mutants were synthesized in a baculovirus system, and recombinant mutants also decreased the serum calcium level of mice. These data implicate caldecrin, a protease closely related to elastase IV, in the regulation of blood calcium levels.
A hybrid approach of support vector machines with logistic regression for β-turn prediction

A β-turn is a secondary protein structure type that plays a significant role in protein folding, stability, and molecular recognition. It is the most common type of non-repetitive structures. On average 25% of amino acids in protein structures are located in β-turns. In this paper, we propose a hybrid approach of support vector machines (SVMs) with logistic regression (LR) for β-turn prediction. In this hybrid approach, the non β-turn class in a training set is under-sampled several times and combined with the β-turn class to create a number of balanced sets. Each balanced set is used for training one SVM at a time. The results of the SVMs are aggregated by using a logistic regression model. By adopting this hybrid approach, we cannot only avoid the difficulty of imbalanced data, but also have outputs with probability, and less ambiguous than combining SVM with other methods such as voting. Our simulation studies on BT426, and other datasets show that this hybrid approach achieves favorable performance in predicting β-turns as measured by the Matthew correlation coefficient (MCC) when compared with other competing methods.
One year of baclofen in 100 patients with or without cirrhosis: a French real-life experience

Background Several studies have suggested the efficacy of baclofen in reducing alcohol consumption, leading to a temporary recommendation for use in France. Aim Our aim was to report our experience in using baclofen in alcohol-dependant patients with or without liver cirrhosis. Patients and methods Consecutive patients from two liver and alcohol units were recruited over a 3-year period and received increasing doses of baclofen associated with social, psychological, and medical care. Results One hundred patients were treated, of whom 65 were cirrhotic. After 1 year, 86 patients were still being followed up. At a mean dosage of 40 mg/day (extremes: 30–210), the median daily alcohol consumption reduced from 80 to 0 g/day (P<0.001). Twenty patients drank a small amount of alcohol of up to 30 g/day and 44 patients were completely abstinent. These declarative results were associated with a significant improvement in alcohol-related biological markers in this ‘low-consumption’ group of 64 patients: the median &ggr;-glutamyl transferase decreased from 3.9 to 2.0 UNL (P<0.001), the mean aspartate transaminase decreased from 2.6 to 1.2 UNL (P<0.001), and the mean corpuscular volume decreased from 101 to 93 µm3 (P<0.001). In cirrhotic patients, bilirubinemia decreased significantly from 22 to 11 µmol/l (P=0.026), prothrombin time increased from 68 to 77% (P<0.001), and albuminemia increased from 34.1 to 37.4 g/l (P<0.001). Twenty patients reported grades 1–2 adverse events. No liver or renal function deterioration occurred in cirrhotic patients. Conclusion In our cohort, baclofen associated with a global care was very well tolerated even in cirrhotic patients. The marked reduction in alcohol consumption in 64 patients translated into a significant improvement in biological markers and in liver function tests. Baclofen could be very useful, especially in cases of severe alcoholic liver disease.
Extreme respiratory sinus arrhythmia in response to superimposed head-down tilt and deep breathing.

BACKGROUND Respiratory sinus arrhythmia (RSA) is characterized by normal fluctuations in heart rate in phase with the respiratory cycle. There are many proposed mechanisms underlying the RSA phenomenon, including respiratory-induced cardiac loading (i.e., Bainbridge reflex), arterial baroreflex activation, vagal feedback from pulmonary stretch receptors, and central neural mechanisms. It is currently unclear to what extent these mechanisms are responsible for eliciting RSA in humans, particularly in response to stressors. CASE REPORT Here we present a case report of a healthy 26-yr-old woman (BMI 22.95 kg · m(-2)) who developed extreme RSA when exposed to the simultaneous cardiac loading stressors of 45° head-down tilt (HDT) and increased tidal volume during CO2 rebreathing. During baseline breathing in both supine and 45° HDT position, RSA magnitude was similar (mean ∼10-14 bpm). RSA was tidal volume-dependent, whereby in the supine position the RSA magnitude doubled with an approximate doubling in tidal volume during rebreathing (mean ∼20 bpm). However, when HDT and rebreathing were superimposed, extreme RSA was elicited (mean ∼45 bpm; range ∼38-110 bpm), approximately 450% over baseline breathing in the supine position. ECG analysis and follow up medical assessment revealed no underlying cardiac pathology. DISCUSSION The existence of extreme RSA when HDT and increased inspired volumes were superimposed suggests that the dual cardiac loading stimuli acted synergistically, increasing RSA magnitude over either stimulus alone. This case report may be relevant to situations where orthostatic stress and augmented tidal volumes are superimposed, or more generally when conflicting sympathetic and parasympathetic activation is simultaneous.
Introduction of Exogenous Epitopes in the Variable Regions of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Effect on Viral Infectivity and the Neutralization Phenotype

ABSTRACT In this study we examined whether human immunodeficiency virus type 1 (HIV-1) is equally susceptible to neutralization by a given antibody when the epitope of this antibody is introduced at different positions within the viral envelope glycoprotein (Env). To this end, we introduced two exogenous “epitope tags” at different locations within three major Env regions in two distinct HIV-1 isolates. We examined how the introduction of the exogenous epitopes affects Env expression, Env incorporation into virions, Env fusogenic potential, and viral susceptibility to neutralization. Our data indicate that even within the same Env region, the exact positioning of the epitope impacts the susceptibility of the virus to neutralization by the antibody that binds to that epitope. Our data also indicate that even if the same epitope is introduced in the exact same position on two different Envs, its exposure and, as a result, the neutralization susceptibility of the virus, can be very different. In contrast to the findings of previous studies conducted with HIV-1 isolates other than those used here, but in agreement with results obtained with simian immunodeficiency virus, we observed that tagging of the fourth variable region of Env (V4) did not result in neutralization by the anti-tag antibodies. Our data indicate that epitopes in V4 are not properly exposed within the functional HIV-1 trimeric Env spike, suggesting that V4 may not be a good target for vaccine-elicited neutralizing antibodies.
Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis.

BACKGROUND & AIMS In cirrhosis, an insufficient release of nitric oxide contributes to increased hepatic resistance and portal pressure and enhances the postprandial increase in portal pressure. We hypothesized that simvastatin, which enhances Akt-dependent endothelial nitric oxide synthase phosphorylation, may increase hepatic nitric oxide release and decrease hepatic resistance in patients with cirrhosis and portal hypertension. METHODS In protocol 1, 13 patients had measurements of the hepatic venous pressure gradient, hepatic blood flow, mean arterial pressure, cardiac output, and nitric oxide products before and 30 and 60 minutes after 40 mg of simvastatin. In protocol 2, 17 patients were randomized to receive placebo or simvastatin (40 mg) 12 hours and 1 hour before the study. After baseline measurements of the hepatic venous pressure gradient, hepatic blood flow, and nitric oxide products, a standard liquid meal was given, and measurements were repeated at 15, 30, and 45 minutes. RESULTS In protocol 1, acute simvastatin did not modify the hepatic venous pressure gradient but increased the hepatic blood flow (21% +/- 13% at 30 minutes; P = 0.01) and decreased hepatic sinusoidal resistance by 14% +/- 11% (P = 0.04). Nitric oxide product levels significantly increased in hepatic venous blood (from 31.4 +/- 12.3 nmol. mL(-1) to 35.8 +/- 10.7 nmol. mL(-1); P = 0.04), but not in peripheral blood. Systemic hemodynamics were not modified. In protocol 2, simvastatin pretreatment significantly attenuated the postprandial increase in hepatic venous pressure gradient (mean peak increase, 10% +/- 9% vs. 21% +/- 6% in placebo; P = 0.01). Hepatic blood flow increased similarly in the 2 groups. Hepatic nitric oxide products increased in the simvastatin group but not in the placebo group. CONCLUSIONS Simvastatin administration increases the hepatosplanchnic output of nitric oxide products and decreases hepatic resistance in patients with cirrhosis.