Miracle-dz/UniFAR-FTUs huggingface dataset:
Strengthening Social Networks in Online Discussion Forums to Facilitate Help Seeking for Solving Problems

Help seeking is regarded as an important learning strategy that reflects students’ metacognitive and domainspecific skills and knowledge. This study developed a proactive online discussion forum that strengthens social networks in an online discussion forum to facilitate help seeking for problem solving. This forum allowed students to proactively invite friends or potential experts to participate in problem solving. A quasiexperimental approach was conducted with a sample of 37 students. The students’ behaviors of problem solving, ego network patterns of problem solving, and perceptions of help seeking were addressed as dependent variables to assess the effect of the proactive online discussion forum. The analysis results revealed that the students in the experimental group exhibited more frequent participation in problem solving, and showed more positive attitudes towards help seeking. The results also indicated that the experimental group demonstrated more in-depth participation patterns of ego networks. The findings provide some evidence for the effectiveness of the proactive online discussion forum in terms of promoting students’ participation in problem solving and their attitudes towards help seeking.
Randomized Placebo‐Controlled Trial Assessing the Effect of 24‐Week Fenofibrate Therapy on Circulating Markers of Abdominal Aortic Aneurysm: Outcomes From the FAME‐2 Trial

Background There is no drug therapy for abdominal aortic aneurysm (AAA). FAME‐2 (Fenofibrate in the Management of Abdominal Aortic Aneurysm 2) was a placebo‐controlled randomized trial designed to assess whether administration of 145 mg of fenofibrate/d for 24 weeks favorably modified circulating markers of AAA. Methods and Results Patients with AAAs measuring 35 to 49 mm and no contraindication were randomized to fenofibrate or identical placebo. The primary outcome measures were the differences in serum osteopontin and kallistatin concentrations between groups. Secondary analyses compared changes in the circulating concentration of AAA‐associated proteins, and AAA growth, between groups using multivariable linear mixed‐effects modeling. A total of 140 patients were randomized to receive fenofibrate (n=70) or placebo (n=70). By the end of the study 3 (2.1%) patients were lost to follow‐up and 18 (12.9%) patients had ceased trial medication. A total of 85% of randomized patients took ≥80% of allocated tablets and were deemed to have complied with the medication regimen. Patients’ allocated fenofibrate had expected reductions in serum triglycerides and estimated glomerular filtration rate, and increases in serum homocysteine. No differences in serum osteopontin, kallistatin, or AAA growth were observed between groups. Conclusions Administering 145 mg/d of fenofibrate for 24 weeks did not significantly reduce serum concentrations of osteopontin and kallistatin concentrations, or rates of AAA growth in this trial. The findings do not support the likely benefit of fenofibrate as a treatment for patients with small AAAs. Clinical Trial Registration URL: http://www.anzctr. org.au. Unique identifier: ACTRN12613001039774.
Attention-Based Capsule Networks with Dynamic Routing for Relation Extraction

A capsule is a group of neurons, whose activity vector represents the instantiation parameters of a specific type of entity. In this paper, we explore the capsule networks used for relation extraction in a multi-instance multi-label learning framework and propose a novel neural approach based on capsule networks with attention mechanisms. We evaluate our method with different benchmarks, and it is demonstrated that our method improves the precision of the predicted relations. Particularly, we show that capsule networks improve multiple entity pairs relation extraction.
CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias

Background The sodium channel, Nav1.5, encoded by SCN5A, undergoes developmentally regulated splicing from inclusion of exon 6A in the fetal heart to exon 6B in adults. These mutually exclusive exons differ in 7 amino acids altering the electrophysiological properties of the Nav1.5 channel. In myotonic dystrophy type 1, SCN5A is mis‐spliced such that the fetal pattern of exon 6A inclusion is detected in adult hearts. Cardiac manifestations of myotonic dystrophy type 1 include conduction defects and arrhythmias and are the second‐leading cause of death. Methods and Results This work aimed to determine the impact of SCN5A mis‐splicing on cardiac function. We used clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated protein 9 (Cas9) to delete Scn5a exon 6B in mice, thereby redirecting splicing toward exon 6A. These mice exhibit prolonged PR and QRS intervals, slowed conduction velocity, extended action potential duration, and are highly susceptible to arrhythmias. Conclusions Our findings highlight a nonmutational pathological mechanism of arrhythmias and conduction defects as a result of mis‐splicing of the predominant cardiac sodium channel. Animals homozygous for the deleted exon express only the fetal isoform and have more‐severe phenotypes than heterozygotes that also express the adult isoform. This observation is directly relevant to myotonic dystrophy type 1, and possibly pathological arrhythmias, in which individuals differ with regard to the ratios of the isoforms expressed.
New Residue Number System Scaler for the Three-Moduli Set {2n+1 - 1, 2n, 2n - 1}

This work proposes the first scaler designed specifically for the three-moduli set M 1 = { 2 n + 1 − 1 , 2 n , 2 n − 1 } . Hence, there is no other functionally similar scaler to compare the proposed scaler with. However, when compared with the latest published scalers for a different moduli set, M 2 = { 2 n + 1 , 2 n , 2 n − 1 } , the proposed scaler has a better area and power performance, while it requires a longer time delay. As demonstrated in earlier publications, replacing the ( 2 n + 1 ) channel in the M 2 moduli set by the ( 2 n + 1 − 1 ) channel, to form the M 1 moduli set, considerably improves the overall time performance of residue-based multiply–accumulate arithmetic units.
Removal of Cadmium and Lead from Contaminated Soils Using Sophorolipids from Fermentation Culture of Starmerella bombicola CGMCC 1576 Fermentation

Soil contaminated with Cd and Pb has caused sharp decrease of cultivatable soil and has been attracting increasing attention. Biosurfactants are efficient in solving the problem. However, little information is available about the influence of sophorolipids (SLs) on the remediation of Cd- or Pb-contaminated soil. The sophorolipids produced by Starmerella bombicola CGMCC 1576 were used to study the effects of Cd and Pb removal in batch soil washing from artificially contaminated soil. The removal efficiency of crude total SLs was better than both distilled water and synthetic surfactants. Furthermore, 83.6% of Cd and 44.8% of Pb were removed by 8% crude acidic SLs. Acidic SLs with high water solubility were more effective than lactonic SLs in enhancing remediation of heavy metal-contaminated soils. The complexation of Cd with the free carboxyl group of the acidic SLs was observed by Fourier-transform infrared spectroscopy study, and this complexation was effective in heavy metal removal from the soil. The fermentation broth of S. bombicola, without further preparation, removed 95% of Cd and 52% of Pb. These results suggested that SLs produced by S. bombicola could function as potential bioremediation agents for heavy metal-contaminated soil.
Short-course regimens of rifapentine plus isoniazid to treat latent tuberculosis infection in older Chinese patients: a randomised controlled study

Latent tuberculosis infection (LTBI) management is now a critical component of the World Health Organization's End TB Strategy. In this randomised controlled trial (Chinese Clinical Trial Registry identifier ChiCTR-IOR-15007202), two short-course regimens with rifapentine plus isoniazid (a 3-month once-weekly regimen and a 2-month twice-weekly regimen) were initially designed to be evaluated for rural residents aged 50–69 years with LTBI in China. Due to the increasingly rapid growth and unexpected high frequency of adverse effects, the treatments were terminated early (after 8 weeks for the once-weekly regimen and after 6 weeks for the twice-weekly regimen). In the modified intention-to-treat analysis on the completed doses, the cumulative rate of active disease during 2 years of follow-up was 1.21% (14 out of 1155) in the untreated controls, 0.78% (10 out of 1284) in the group that received the 8-week once-weekly regimen and 0.46% (six out of 1299) in the group that received the 6-week twice-weekly regimen. The risk of active disease was decreased, with an adjusted hazard ratio of 0.63 (95% CI 0.27–1.43) and 0.41 (95% CI 0.15–1.09) for the treatments, respectively. No significant difference was found in the occurrence of hepatotoxicity (1.02% (13 out of 1279) versus 1.17% (15 out of 1279); p=0.704). The short regimens tested must be used with caution among the elderly because of the high rates of adverse effects. Further work is necessary to test the ultrashort regimens in younger people with LTBI. A randomised controlled trial suggested that the short regimens tested for treatment of latent tuberculosis infection must be used with caution among the elderly because of the high rates of adverse effects http://ow.ly/AmmM30m7bYd
Context-Dependent Sensitivity to Losses: Range and Skew Manipulations

The assumption that losses loom larger than gains is widely used to explain many behavioral phenomena in judgment and decision-making. It is also generally accepted that loss aversion is a stable, traitlike individual difference characterizing people’s sensitivity to gains and losses. This interpretation was recently challenged by Walasek and Stewart (2015), who showed that by manipulating the range of the gains and losses used in the accept−reject task it is possible to find loss aversion, loss neutrality, and a reversal of loss aversion. Here, we reexamined the claim that these context effects arise as a result of people being sensitive to the rank position of a given gain among other gains and the rank position of a loss among other losses. We used skewed distributions of outcomes to manipulate the rank position of gains and losses while keeping the range of possible outcomes constant. We found a small but robust effect of skew on the propensity to accept mixed gambles. We compared the sizes of skew and range effects and found that they are of similar magnitude but that the range effects are smaller than those reported by Walasek and Stewart. We were able to attenuate loss aversion, but we were not able to replicate Walasek and Stewart’s reversal of loss aversion. We conclude that rank effects are, at least in part, responsible for the loss aversion seen in the accept−reject task.
Text-Adaptive Generative Adversarial Networks: Manipulating Images with Natural Language

This paper addresses the problem of manipulating images using natural language description. Our task aims to semantically modify visual attributes of an object in an image according to the text describing the new visual appearance. Although existing methods synthesize images having new attributes, they do not fully preserve text-irrelevant contents of the original image. In this paper, we propose the text-adaptive generative adversarial network (TAGAN) to generate semantically manipulated images while preserving text-irrelevant contents. The key to our method is the text-adaptive discriminator that creates word level local discriminators according to input text to classify fine-grained attributes independently. With this discriminator, the generator learns to generate images where only regions that correspond to the given text is modified. Experimental results show that our method outperforms existing methods on CUB and Oxford-102 datasets, and our results were mostly preferred on a user study. Extensive analysis shows that our method is able to effectively disentangle visual attributes and produce pleasing outputs.
Does the Optimal Dietary Methionine to Cysteine Ratio in Diets for Growing Chickens Respond to High Inclusion Rates of Insect Meal from Hermetia illucens?

Simple Summary Currently, several alternative protein sources are under investigation for replacing soybean meal in poultry diets. One alternative is larvae meal of the black soldier fly (Hermetia illucens) with a specific sulfur amino acid composition. The larvae meal is limiting in sulfur amino acids supply and provides a wide methionine:cysteine ratio of 61:39. Currently, it is not known whether the insect meal has an impact on the optimal ratio of methionine to cysteine in broiler chicken diets. The methionine:cysteine ratio significantly influences animal growth and welfare. Both methionine and cysteine excess and deficiency can lead to an impaired feed intake, growth, and feed efficiency. Therefore, the aim of this study was to investigate whether the optimal methionine:cysteine ratio is modulated when a high inclusion rate of partly defatted Hermetia illucens meal is applied. The results show that a methionine:cysteine ratio of 50:50 yields superior growth and dietary protein quality. It can be concluded that the insect meal under study is a promising alternative protein source without modulating the optimal methionine:cysteine ratio in broiler chicken diets. Abstract The dietary methionine:cysteine (Met:Cys) ratio (MCR) is an important factor influencing the optimal growth of chickens. Therefore, this study aimed to contribute to the assessment of the optimal dietary MCR in diets with the complete replacement of soybean meal (SBM) by a partly defatted larvae meal of Hermetia illucens (HM). A growth study with 240 male meat-type chickens (Ross 308) was conducted, also assessing the body nutrient deposition both at the end of the starter (day 21) and the grower (day 35) period. Birds were fed experimental diets based on wheat, maize, and insect meal (23%/21% HM in starter/grower diets). Sulfur amino acids were created as the limiting AA in diets with graded MCR (40:60; 45:55; 50:50; 55:45; 60:40). The control diet contained SBM instead of HM with a MCR of 50:50. The current results based on growth parameters, dietary protein quality, and Met efficiency data gave support to the previous assumption of an ideal MCR of 50:50, which was also valid in diets with a high proportion of insect meal. The lowest MCR of 40:60 led to significantly impaired feed intake and growth of the birds, while the response to the highest MCR (60:40) was moderate.
Relations of Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness in Blacks: The Jackson Heart Study

Background Blacks have more severe endothelial dysfunction and aortic stiffening as compared with whites. We aimed to investigate the association between aortic stiffness and microvascular function in the black community. Methods and Results We assessed the association between forearm vascular reactive hyperemia (an indicator of microvascular function) and aortic stiffness in 1458 black participants (N=965 [66% women]; mean age: 66±11 years) in the Jackson Heart Study. We evaluated 2 measures of aortic stiffness: brachial pulse pressure and carotid‐femoral pulse wave velocity. Using high‐resolution ultrasound and Doppler, we evaluated brachial blood flow at baseline and during reactive hyperemia after 5 minutes of forearm ischemia. Multiple cardiovascular risk factors were significantly related to baseline and hyperemic brachial flow velocity. Women had lower baseline flow across the entire age spectrum. During hyperemia, we observed a significant age‐sex interaction for flow velocity (P=0.02). Female sex was protective against microvascular dysfunction among younger participants, but older women exhibited a greater attenuation of the hyperemic flow reserve. In multivariable models that adjusted for cardiovascular disease risk factors and mean arterial pressure, higher carotid‐femoral pulse wave velocity (β=−0.106±0.033; P=0.001 was related to lower baseline flow. However, during reactive hyperemia, elevated brachial pulse pressure (β=−0.070±0.031; P=0.03) and carotid‐femoral pulse wave velocity (β=−0.128±0.030; P<0.001) were both related to attenuated brachial flow velocity. Conclusions In a sample of blacks, higher aortic stiffness and pressure pulsatility were associated with lower flow reserve during reactive hyperemia, beyond changes attributable to traditional cardiovascular disease risk factors alone.
Safety and Efficiency of Cervical Disc Arthroplasty in Ambulatory Surgery Centers vs. Hospital Settings

ABSTRACT Background: Outpatient surgery has been shown safe and effective for anterior cervical discectomy and fusion (ACDF), and more recently, for 1-level cervical disc arthroplasty (CDA). The purpose of this analysis is to compare the safety and efficiency of 1-level and 2-level CDA performed in an ambulatory surgery center (ASC) and in a hospital setting. Methods: The study was a retrospective collection and analysis of data from consecutive CDA patients treated in ASCs compared to a historical control group of patients treated in hospital settings who were classified as outpatient (0 or 1-night stay) or inpatient (2 or more nights). Surgery time, blood loss, return to work, adverse events (AEs), and subsequent surgeries were compared. Results: The sample consisted of 145 ASC patients, 348 hospital outpatients, and 65 hospital inpatients. A greater proportion of 2-level surgeries were performed in hospital than ASC. Surgery times were significantly shorter in ASCs than outpatient or inpatient 1-level (63.6 ± 21.6, 86.5 ± 35.8, and 116.7 ± 48.4 minutes, respectively) and 2-level (92.4 ± 37.3, 126.7 ± 43.8, and 140.3 ± 54.5 minutes, respectively) surgeries. Estimated blood loss was also significantly less in ASC than outpatient and inpatient 1-level (18.5 ± 30.6, 43.7 ± 35.9, and 85.7 ± 98.0 mL, respectively) and 2-level (21.1 ± 12.3, 67.8 ± 94.9, and 64.9 ± 66.1 mL). There were no hospital admissions and no subsequent surgeries among ASC patients. ASC patients had 1 AE (0.7%) and hospital patients had 10 AEs (2.4%). Working patients returned to work after a similar number of days off, but fewer ASC patients had returned to work by the end of the 90-day period. Conclusions: Both 1- and 2-level CDA may be performed safely in an ASC. Surgeries in ASCs are of shorter duration and performed with less blood loss without increased AEs.
Muscle Damage–Based Recovery Strategies Can Be Supported by Predictive Capacity of Specific Global Positioning System Accelerometry Parameters Immediately a Post-Soccer Match-Load

Abstract da Silva, CD, Machado, G, Fernandes, AA, Teoldo, I, Pimenta, EM, Marins, JCB, and Garcia, ES. Muscle damage–based recovery strategies can be supported by predictive capacity of specific global positioning system accelerometry parameters immediately after soccer match-load. J Strength Cond Res 35(5): 1410–1418, 2021—Soccer match-load can be linked to recovery kinetic markers. However, match variability hinders the magnitude of relationship between parameters of interest. Therefore, we examined the correlation between 21 global positioning system accelerometry (GPS-A) parameters and changes in serum creatine kinase (CK) concentrations, muscle soreness (MS), and perceptive recovery quality (PRQ) assessed at baseline (1 h before) and post (0 minute, 2, 4, and 24 hours) a standardized 90-minute match-simulation in 20 university players. Global positioning system accelerometry (15 Hz) data were tested as manufacturer and configurable thresholds. Four GPS-A parameters showed moderate to very large correlations with CK changes at all time points (average speed [avgSP, r = 0.75 to r = 0.84]; running symmetry foot strikes [RSfst, r = 0.53–0.63]; running series [RunS, r = 0.53–0.61]; and acceleration distance [AccD ≥ 1.5 m·s−2; r = 0.46–0.61]). Sprint count (≥2 m·s−2), AccD (≥2.5 m·s−2) and speed exertion (SpEx) had a moderate to large correlation (r = 0.46–0.56) with CK changes from 2 to 24 hours. Changes in MS at 0 minute had large correlation with avgSP (r = 0.53) and moderate with deceleration distance (≥−2 and ≥−3 m·s−2; r = 0.47, r = 0.48, respectively). The PRQ changes had moderate inverse correlation with avgSP at 0 minute (r = −0.39) and SpEx at 2 h (r = −0.69). Our results suggest that during a simulated soccer protocol with a standard workload, only the avgSP has practical application for predicting CK changes over 24 hours, allowing for a decision-making toward a postgame recovery based on previously known CK cutoff points. Global positioning system accelerometry parameters and subjective variables did not demonstrate relevant correlation.
Agreement between blood draw techniques for assessing platelet activation by flow cytometry

Abstract It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into vacuum tubes or manually aspirated syringes, and (2) discarding the first drawn blood sample (discard tube). Platelet P-selectin expression and platelet-monocyte complexes were measured by flow cytometry under both basal conditions and following stimulation with 0.1, 1, or 10 µM ADP. Bland-Altman plots demonstrated agreement between results for vacuum tube and syringe-aspirated samples with an a priori-defined clinically relevant agreement limit of 5%. Agreement of results was also observed between discard tube and second draw samples for both vacuum-driven and manually aspirated blood. We conclude that a vacuum tube or a manually-aspirated syringe can be used when assessing platelet activation by flow cytometry and that there is no need for a discard tube.
Pre-impact Alarm System for Fall Detection Using MEMS Sensors and HMM-based SVM Classifier

Accidental fall can cause physical injury, fracture and other health complication, especially for elderly people living alone. Aimed to provide timely assistance after the occurrence of falling down, a pre-fall alarm system was proposed. In order to test the reliability of pre-fall alarm system, eighteen subjects who worn this device on the waist were required to participate in a series of experiments. The acceleration and angular velocity time series extracted from human motion processes were used to described human motion features. HMM-based SVM classifier was used to determine the maximum separation boundary between fall and Activities of Daily Living (ADLs). The fall detection results showed 94.91% accuracy, 97.22% Sensitivity and 93.75% Specificity. The proposed device can accurately recognize fall event, achieve additional functions, and have advantages of small size and low power consumption. Based on the findings, this pre-impact fall alarm system with detection algorithm could potentially be useful for monitoring the state of physical function in elderly population.