Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of the testicular damage induced by dianabol and its effect on morphological and histological changes in albino male rats

Began sports and physical stimulants used controversial by thanking by the therapeutic use of by athletes and non-athletes. Anabolic androgenic steroids (AAS) have been associated with several side effects range from hypogonadism to cardiac and hepatic dysfunction and alteration of blood lipid levels. This research was undertaken to observe the harmful effect of androgenic anabolic steroids over the male reproductive system. Mature male rats of Sprague Dawley strain, weighing 300-400 g b.w. each and 12-14 weeks old were obtained from the Laboratory Animal Colony, Kufa University. Twenty-four male rats were randomly divided into 4 groups, each with 6 animals. Group (1) was given 0.5 ml distilled water/day (vehicle) and kept as control normal. Rats of group (2) (3), (4) were treated orally with 10, 20, 40mg/kg b.w. /day for 8 weeks. Semen samples were collected from the cuda epidedemis of sacrificed rats under Phenobarbital anesthesia and semen was used for estimating the sperm characters. The testes and head of epididymus were carefully dissected out and weighed. These organs were then kept in 10% formalin solution pending for histopathological examination. the result shows the decrease of live sperm count & the increased dead sperm in rats treated with Dianabol.on the other hand increase of abnormality (deformity of sperm cell) in rats treated with Dianabol. Histopathological section in the caput epididymal tubules 10mg/kg and 20mg/kg of animals at 7 weeks post-treatment. Severe cystic distension of epididymal tubules with severe hyalinization of spermatied resulting in narrowing of tubular tissue , while Histopathological section in the . 40 mg/kg of animal at 7 weeks post-treatment. Variable degree of tubular destruction together with loss of spermatied and evidence of epididymal tubular distortion with hyperplasia. So it is advisable to stay away from these drugs only for therapeutic purposes and a few doses for a limited period Keyward: Anabolic androgenic steroids , dianabol , testestron.
Inflammatory responses, matrix remodeling, and re‐epithelialization after fractional CO2 laser treatment of scars

Fractional CO2 laser therapy has been used to improve scar pliability and appearance; however, a variety of treatment protocols have been utilized with varied outcomes. Understanding the relationship between laser power and extent of initial tissue ablation and time frame for remodeling could help determine an optimum power and frequency for laser treatment. The characteristics of initial injury caused by fractional CO2 laser treatment, the rates of dermal remodeling and re‐epithelialization, and the extent of inflammation as a function of laser stacking were assessed in this study in a porcine scar model.
Impact of Dividend Payout Ratio on the Value of Firm: A Study of Companies Listed on the Nigerian Stock Exchange

The purpose of this study was to examine the impact of dividend payout ratio on the value of firm. The study also examined other factors that affect the value of firm while employing companies listed on the Nigerian stock exchange. The factors which were considered to affect the value of the firm in this study include profitability, leverage policy ratio, dividend policy ratio, cash holding and the size of the firm. The study employed Panel Ordinary Least Square Regression Techniques in analyzing the collated data. The sample in this study is drawn from breweries and beverages companies listed on the Nigerian stock exchange between the periods 2007-2016. The results showed that profitability ratio and leverage ratio positively and significantly impact on the value of the firm. This implies that only the variables of Firm Leverage, and Profit after Tax are significant factors that drives firm value in both breweries and beverages companies among listed companies in Nigeria. The study however recommends that corporate managers whose interest is to raise firm value should ensure the maximization of Profit after Tax, and focus on policies that will improve the leverage ratio of the firm.
Social difficulty in a student sample.

Summary. Recent research shows a high prevalence of psycho-social disturbance in university students, and there is some evidence that inadequate social participation is associated with disturbance and with failure to complete courses. This study examines the extent, degree and type of difficulty in social situations reported by a random sample of Oxford University students. Nearly 10 per cent, mostly from lower social classes and small families, had great difficulty in, or tried to avoid, about six common social situations described in a questionnaire, and a principal components analysis discriminated different types of social difficulty.
The Short Form of the Geriatric Depression Scale: A Comparison With the 30-Item Form

The Geriatric Depression Scale (GDS) exists in both short and long forms. The original 30-item form of the GDS has been shown to be an effective screening test for depression in a variety of settings. However, its utility in patients with demen tia of the Alzheimer type (DAT) is questionable. The short, 15-item version of the GDS was developed primarily for brev ity and, in particular, for use in populations such as the medically ill or those with dementia, where the longer form might be burdensome. How well this short form works in these populations, however, is largely undetermined. In this paper, the sensitivity and specificity of the 15- and 30-item GDS are compared in a group of patients who were either cognitively intact or had mild DAT. The findings suggest that the short version of the GDS, like its longer prede cessor, is an effective screening tool in the cognitively intact. However, in a population of subjects with mild DAT, it does not appear to retain its validity. (J Geriatr Psychiatry Neurol 1991;4:173-178).
Biological Evaluation of New Schiff Bases: Synthesized from 4-Amino-3,5-dimethyl-1,2,4-triazole, Phenathroline and Bipyridine Dicarboxaldehydes

Four new Schiff bases with promising anticancer activity have been synthesized from 4-amino-3,5-dimethyl-1,2,4-triazole and di-pyridyl-aldehydes. Structures have been established by various spectroscopic methods. The compounds were tested in vitro to study their cytotoxicity and anti-oxidative activity in human lung carcinoma (A549), breast carcinoma (BT549), prostate adenocarcinoma (PC3) and mouse preadipocytes (3T3-L1) cells. Compound 1 was found to increase Glutathione (GSH) level slightly in all four cell lines. Compound 4 showed better selectivity and cytotoxicity against both BT549 and A549 cells compared to the anticancer drug tamoxifen. With the exception of compound 4 which reduced GSH levels in A549 and BT549, all other compounds maintained GSH levels in comparison to their respective controls.
Behavioral and Organizational Considerations in the Design of Information Systems and Processes for Planning and Decision Support

Determinants of performance of systems and processes for planning and decision support are discussed. This paper is directed at people who design such systems and processes, who use such systems and processes, and who manage organizations in which these may be used. The literature cited is associated with several areas including psychology, organizational behavior and design, information science, management science, computer science, and related disciplines. Performance determinants and design requirements for systems and processes for planning and decision support are especially stressed. A number of areas where additional research appears needed are mentioned, and some recommendations and interpretations are given concerning both contemporary efforts and needed future efforts.
Title : Cloning and Identification of MicroRNAs in Wild Soybean ( Glycine soja ) Running title : MicroRNAs in Wild Soybean

MicroRNAs (miRNAs) play important roles in post-transcriptional gene silence by directing target mRNA cleavage or translational inhibition. Currently, hundreds of miRNAs have been identified in plants, but no report has been published in wild soybean (Glycine soja). We constructed a small-RNA library consisting of 2880 sequences with high quality, in which 1347 were 19-24 nt in length. By utilizing the miRNA, Rfam and domesticated soybean EST database, we have analyzed and predicted the secondary structure of these small RNAs. As a result, 15 conserved miRNA candidates belonging to 8 different families and 9 novel miRNA candidates comprising 8 families were identified in wild soybean seedlings. All these miRNA candidates were validated by Northern blot and the novel candidates expressed in a tissue specific manner. Furthermore, putative target genes were predicted for novel miRNA candidates and two of them were verified by 5’-RACE experiments. These results provided useful information for miRNA research in wild soybean and plants.
A Single Heteroclitic Epitope Determines Cancer Immunity After Xenogeneic DNA Immunization Against a Tumor Differentiation Antigen1

Successful active immunization against cancer requires induction of immunity against self or mutated self Ags. However, immunization against self Ags is difficult. Xenogeneic immunization with orthologous Ags induces cancer immunity. The present study evaluated the basis for immunity induced by active immunization against a melanoma differentiation Ag, gp100. Tumor rejection of melanoma was assessed after immunization with human gp100 (hgp100) DNA compared with mouse gp100 (mgp100). C57BL/6 mice immunized with xenogeneic full-length hgp100 DNA were protected against syngeneic melanoma challenge. In contrast, mice immunized with hgp100 DNA and given i.p. tolerizing doses of the hgp100 Db-restricted peptide, hgp10025–33, were incapable of rejecting tumors. Furthermore, mice immunized with DNA constructs of hgp100 in which the hgp10025–27 epitope was substituted with the weaker Db-binding epitope from mgp100 (mgp10025–27) or a mutated epitope unable to bind Db did not reject B16 melanoma. Mice immunized with a minigene construct of hgp10025–33 rejected B16 melanoma, whereas mice immunized with the mgp10025–33 minigene did not develop protective tumor immunity. In this model of xenogeneic DNA immunization, the presence of an hgp100 heteroclitic epitope with a higher affinity for MHC created by three amino acid (25 to 27) substitutions at predicted minor anchor residues was necessary and sufficient to induce protective tumor immunity in H-2b mice with melanoma.
Work Motivation and Teams

We provide a new measure of work motivation and show that motivation shapes the effects of team incentives and observation by peers on performance. In particular, we measure motivation to work hard as the deviation from the money-maximizing benchmark in a real-effort experiment. While we find that average output increases in response to team incentives and observation, we find that highly motivated workers do not respond. The reason is that highly motivated workers already work hard and increasing effort even further is very costly to them.
A novel apolipoprotein E mutation, ApoE Tsukuba (Arg 114 Cys), in lipoprotein glomerulopathy.

Lipoprotein glomerulopathy (LPG) is considered a type of renal lipidosis, characterized by the presence of lipoprotein thrombi in markedly dilated capillary lumina of the affected glomeruli [1]. LPG is a rare disease; approximately 65 cases have been reported to date [2]. Patients with LPG exhibit proteinuria and progressive renal dysfunction. In most of the LPG patients, levels of intermediate-density lipoproteins are elevated, resembling type III hyperlipoproteinaemia; moreover, apolipoprotein E (ApoE) levels are also elevated. Recent genetic studies have revealed that several ApoE gene mutations are associated with LPG [3]. In this study, we report a LPG patient with a novel ApoE mutation, without plasma lipid and lipoprotein abnormalities or elevated ApoE level.
Estimation of skin phototypes with optical parameters: an experimental study using newly developed fibre optic detection device

In an experimental study (October 2010 Mannheim Germany) with 99 Caucasian volunteers, the skin colour (L*, a*, b*) and the reflectance spectra of human skin were compared to the Fitzpatrick's sun‐reactive skin photo types (SPT). For this purpose, the skin colour and the reflectance spectra of human skin were determined using non‐invasive method with a newly developed fibre optic detection device. The device, based on reflectance spectroscopy, was designed and optimized using a commercial optical analysis Software. By means of the measured spectra of scattered light, the colour values and the absorption spectra of the skin were calculated. Neither any of the L*, a*, b* colour values nor any of the parameters of the absorbance spectra can be used alone to assess the skin type properly. Therefore, an ordinal logistic regression analysis was performed, using the statistical computing software r, to correlate the skin types with the measured optical parameters. It turned out that the detection device combined with the extended statistical analysis gives a better estimate of skin type in respect of the measured optical parameters than a procedure with only L*, a*, b* colour values. Even with the extended methodology, the procedure gives only a rough estimation of the skin type.
Making Space for Women: Explaining Citizen Support for Legislative Gender Quotas in Latin America

Gender quotas have been adopted in over a hundred countries in an effort to address gender disparities in national legislatures. Yet the determinants of citizen support for gender quota policies remain largely understudied. We develop a theory that emphasizes the impact of institutional performance and political values to explain citizen support for gender quotas and how these two factors differentially influence men’s and women’s quota support. Based on data for 24 Latin American countries, we find that citizens in countries with relatively good governance quality who express a strong preference for government involvement to improve citizens’ well-being show the highest levels of quota support. Further, whereas good governance increases quota support at a higher rate among men than women, preferences for government involvement exert a stronger influence on women’s support for quotas. Consequently, good governance quality reduces the gender gap in quota support by substantially increasing men’s support for quotas.
A systematic review of the concept of entrepreneurial alertness

Purpose Entrepreneurial alertness is a key factor in business opportunity identification. Scholars have determined that successful entrepreneurs have high levels of entrepreneurial alertness, but only a limited number of studies are available on the concept. One of the major reasons identified is the fragmented constituents and less knowledge of the components determining the level of alertness. The present study aims to integrate the varied research on entrepreneurial alertness, identify its core components and develop the understanding of the concept of entrepreneurial alertness. Design/methodology/approach The study is based on a systematic review of secondary research. The first stage involved identifying relevant publications and applying practical screening. In the second stage, the resources were screened for the inclusion criteria, and in the final stage, the articles meeting the inclusion criteria were read in detail for the final analysis. Findings The review resulted in identification of the following core components of the alertness construct – sensing and searching information, cognitive ability, personality factors (like creativity and self-efficacy), environment, social networks, knowledge and experience. The review also highlighted that cognitive ability plays a central role in alertness. Originality/value Based on the review of literature, the study proposes a model of the alertness construct, which attempts to draw a relationship between the identified components. The review also uncovers several unexplored areas, which still need to be addressed in the area of entrepreneurial alertness.
A Study on Role of Moderating Variables in Influencing Employees’ Acceptance of Information Technology

Penetration of information technology (IT) in almost every sector of the Indian economy is occurring at a very rapid pace. This has brought about a great transformation from a paper world to a digital world. Employees face new technological changes in their workplace almost every day. Some employees welcome the changes brought about by technology while others resist it and become defensive. These differences in employees’ reactions are influenced by a host of moderating variables existing in the environment. For the purpose of the present study, the researchers have adopted three moderating variables, namely, age, gender and experience (from the unified theory of acceptance and use of technology [UTUAT] model of Venkatesh, Morris, Davis, and Davis (2003, MIS Quarterly, 27, 3, 425–478). Hence, the article attempts to study the influence of the aforementioned moderating variables on the employees’ acceptance of IT at their workplace. The study has been conducted in the post offices falling under the Nalbari-Barpeta division of the Assam postal circle. The study is based on both the primary and secondary data.
Eco-Driving Performance Assessment With in-Car Visual and Haptic Feedback Assistance

Dans cette experimentation, 28 participants accomplissent une tâche de conduite dans le simulateur CARDS du Centre Technique de Simulation de Renault. Ce simulateur, equipe du logiciel de simulation SCANeR2 © , delivre un angle de vue de 150° dans un cockpit entierement in strumente. Deux interfaces d'assistance a l'eco-conduite completent le dispositif experimental: un ecran de 7 pouces sur la console centrale et un dispositif appliquant un retour d'effort a la pedale d'accelerateur. Le retour d'information est calcule en comparant l'acceleration instantanee du vehicule a un niveau d'acceleration optimal, d'apres un modele de consommation de moteur diesel Renault. La pratique de l'ecoconduite, comme le changement de rapport sous les 2000 Rpm, permet de reduire significativement les emissions polluantes. L'assistance des conducteurs avec des systemes d'aide visuel, haptique ou visuo-haptique, permet une reduction supplementaire significative des emissions polluantes. Aucune difference significative n'a ete constatee entre les differents modes d'assistance; ce qui laisse penser que l'assistance haptique engendre la meme ecoperformance que l'assistance visuelle. En particulier, les sujets font preuve d'une adaptation satisfaisante a la pedale haptique lors d'une premiere utilisation du systeme. Ils accordent apparemment plus de confiance a la modalite haptique pour accomplir leur tâche d'eco-conduite en presence d'une assistance visuo-haptique.
Evaluating the Effect of New Local Materials of Evaporative Cooling Pads

The present study aimed to evaluate the feasibility of celdek pads, luffa pads, straw fiber pads and sackcloth pads as alternative pad materials. Experimental measurements were conducted and the experimental data were quantitative. The experimental work mainly focused on the effects of different types and thicknesses of evaporative cooling pads when used for changing the environmental conditions inside greenhouses. Moreover, the experimental work involved the measurement of environmental parameters viz., temperature, relative humidity, air velocity and pressure drops at different times during the day, using the different thickness parameters of the evaporative cooling pads i.e., 50, 100 and 150 mm and the water flow rates through the pads. The data obtained from the experiments and measurements were analyzed using Statistical Package for the Social Sciences Results deciphered that there was a significant difference between evaporative cooling pad types and cooling efficiency. The Luffa pads yielded an average saturation of 73.67%, whereas other pads yielded the following average saturations: straw fiber pads 71.87%, celdek 70.33% and sackcloth 69%. However, there was a highly significant difference between the pad thickness and cooling efficiency. The results obtained for environmental factors, indicated that there was a significant difference between environmental factors and cooling efficiency. In terms of the effect of air velocity on saturation efficiency and pressure drop, higher air velocity decreases saturation efficiency and increases pressure drop across the wetted pad. Finally, the present study indicated that the luffa pads perform better than the other evaporative cooling pads and have higher potential as wetted-pad material.
Toward Cyber Workforce Development: An Exploratory Survey of Information Security Professionals

High-profile cases of network intrusions in private organizations are becoming a regular occurrence, illustrating the vulnerabilities in current information technology. Cybersecurity is an emerging specialization within information technology careers. Demand for cybersecurity professionals greatly outstrips supply, and the disparity is expected to grow. In this paper, we describe existing efforts to professionalize cybersecurity careers and contribute the results of two exploratory surveys of cybersecurity subject-matter experts (SMEs) working in large corporations in California’s Silicon Valley. We asked SMEs about their training and experience, process for threat detection and response, team organization, and major challenges. Our results are the first in a series of studies aimed at bridging the gap between evolving knowledge, skills, and attitudes (KSAs) and the development of training needed to support the cybersecurity workforce.
A possible alternative exercise test for youths with cystic fibrosis: the steep ramp test.

PURPOSE The steep ramp test (SRT) can be used to provide an indication of exercise capacity when gas exchange measurements are not possible. This study evaluated the clinical usefulness of the SRT in adolescents with cystic fibrosis (CF) and compared the physiological responses of the SRT with the standard cardiopulmonary exercise test (CPET). METHODS Forty patients with CF (17 boys and 23 girls; mean ± SD age, 14.7 ± 1.7 years; forced expiratory volume in 1 s, 86% ± 18% of predicted) performed an SRT and a CPET with respiratory gas analysis in a randomized balanced design. Peak work rate (WRpeak), HRpeak, peak minute ventilation (V˙Epeak), and peak oxygen uptake (V˙O2peak) were the main outcome measures. RESULTS Patients with CF attained values for absolute and relative WRpeak during the SRT of 82% ± 14% and 92% ± 14% of predicted. Nutritional status and degree of airway obstruction did not influence SRT performance. Significantly higher values were attained for WRpeak during the SRT compared with those during the CPET (252 ± 60 vs 174 ± 46 W; P < 0.001), whereas significantly lower values were achieved for HRpeak (168 ± 14 vs 182 ± 12 bpm; P < 0.001), V˙Epeak (59.2 ± 19.5 vs 72.0 ± 20.2 L·min(-1); P = 0.006), and V˙O2peak (36.9 ± 7.5 vs 41.5 ± 7.6 mL·kg(-1)·min(-1); P = 0.008). A strong correlation between WRpeak attained at the SRT and the V˙O2peak achieved during the CPET was found (r = 0.822, P < 0.001). CONCLUSIONS The SRT seems to be a quick, convenient, and low-cost exercise test that is well-tolerated in patients with CF with mild-to-moderate airway obstruction. It provides an indication of exercise capacity and can potentially be used when exercise testing using gas exchange measurements is not possible.