Miracle-dz/UniFAR-FTUs huggingface dataset:
FORMAL SEARCH AND REFERRALS FROM A FIRM'S PERSPECTIVE

"This study explores the relationship between firms' characteristics and their recruitment strategies. We propose a model based on a search and matching framework with two search channels: a formal channel which is costly for firms and a costless informal channel, i.e. referrals. There is a continuum of heterogeneous vacancies in our model where every firm with an open vacancy chooses an optimal search effort in order to attract job candidates. This search effort depends on the productivity of the firm and, contrary to the previous literature, workers send simultaneous applications to open vacancies. We assess the model predictions by using the IAB Job Vacancy Survey, a representative survey among human resource managers in Germany reporting information about their most recent recruitment case. Based on the finding that firm size and productivity are positively correlated we show that: (1) Larger firms invest more effort into formal search activities; (2) Firms invest more formal search effort in labour markets for more educated workers; (3) The positive relationship between firm's size and formal search intensity can also be observed for firms that don't use referrals; (4) Firms that use referrals as a search channel invest less effort into formal search compared to firms that don't use referrals; (5) Larger firms are less likely to hire an applicant by referral than smaller firms, and (6) More intensive search effort leads to a larger number of applications. " (Author's abstract, IAB-Doku) ((en))
Vowel recognition: Formants, spectral peaks, and spectral shape

The purpose of this presentation will be to review some recent research on the acoustic characteristics of American English vowels, and to discuss some issues related to the auditory mechanisms underlying vowel recognition. Evidence from studies using traditional formant frequency representations will be reviewed to address issues such as talker normalization and the role of dynamic features in vowel identification. A long‐standing debate in phonetic perception theory concerning whether phonetic quality is controlled by formant frequencies or the overall shape of the spectrum will also be addressed. While formant theory has tended to dominate much of vowel perception research, some compelling arguments have been leveled against formant representations; however, there are also some very important problems with whole‐spectrum representations. A new method of representing speech will be described which is believed to address some of the limitations of both formants and overall spectral shape. The masked peak.
Nerve Growth Factor Modulates the Activation Status and Fast Axonal Transport of ERK 1/2 in Adult Nociceptive Neurones

Mature dorsal root ganglion cells respond to neurotrophins, and the intracellular signalling pathways activated by neurotrophins have been characterized in vitro. We have now used immunocytochemistry and Western blots to examine the expression and activation of extracellular signal-regulated protein kinase-1/2 (ERK) in rat dorsal root ganglion cells in vivo, using antisera to total (tERK) and phosphorylated (pERK) forms. This has revealed a number of novel findings. tERK immunoreactivity is present in most dorsal root ganglion cells but is expressed most strongly in small (nociceptive) cells and, surprisingly, is absent in a population of large cells that expressed trkB or trkC but mainly lack p75(NTR) immunoreactivity. In contrast pERK is prominent in a few trkA cells and in satellite glial cells, and is further increased by NGF treatment. tERK and pERK both undergo fast anterograde and retrograde axonal transport, indicated by accumulation at a sciatic nerve ligature, and NGF reduces the level of retrograde pERK transport.
Antibodies to Endothelial Cell Growth Factor and Obliterative Microvascular Lesions in the Synovium of Patients With Antibiotic‐Refractory Lyme Arthritis

Endothelial cell growth factor (ECGF) was recently identified as the first autoantigen known to be a target of T cell and B cell responses in ∼20% of patients with antibiotic‐refractory Lyme arthritis. The goal of the current study was to look for a pathologic correlate between ECGF autoantibody responses and histologic findings in synovial tissue.
Life expectancy and causes of death in a population treated for serious mental illness.

OBJECTIVE This cross-sectional mortality linkage study describes the prevalence of specific fatal disease and injury conditions in an adult population with serious mental illness. The large sample of decedents and the use of multiple-cause-of-death data yield new clinical details relevant to those caring for persons with serious mental illness. METHODS Age-adjusted frequency distributions and years of potential life lost were calculated by gender and causes of death for persons in the population of 43,274 adults served by the Massachusetts Department of Mental Health who died between 1989 and 1994. Means and frequencies of these variables were compared with those for persons in the general population of the state who did not receive departmental services and who died during the same period. RESULTS A total of 1,890 adult decedents served by the department of mental health were identified by electronic linkage of patient and state vital records. They had a significantly higher frequency of deaths from accidental and intentional injuries, particularly poisoning by psychotropic medications. Deaths from cancer, diabetes, and circulatory disorders were significantly less frequently reported. On average, decedents who had been served by the department of mental health lost 8.8 more years of potential life than decedents in the general population-a mean of 14.1 years for men and 5.7 for women. The differential was consistent across most causes of death. CONCLUSIONS Findings in this study are consistent with previous findings identifying excess mortality in a population with serious mental illness. The high rate of injury deaths, especially those due to psychotropic and other medications, should concern providers.
A retrospective chart review of intramuscular ziprasidone for agitation in children and adolescents on psychiatric units: prospective studies are needed.

OBJECTIVE Our primary objective was to evaluate the effectiveness and tolerability of intramuscular ziprasidone for impulsivity and agitation in psychiatrically hospitalized children and adolescents. Our secondary objective was to examine demographic and clinical factors associated with treatment response. METHOD We conducted a retrospective chart review of children and adolescents admitted to Cincinnati Children's Hospital Medical Center (CCHMC) psychiatric units between January 1, 2002, and July 11, 2005, who received intramuscular ziprasidone. Medical records were reviewed to determine demographic and clinical information as well as tolerability and effectiveness of ziprasidone. The Behavioral Activity Rating Scale (BARS) was used retrospectively to assess clinical response. Regression analyses were performed to evaluate the effect of demographic factors (age, gender, and ethnicity) and primary psychiatric diagnoses on treatment response. Electrocardiogram (ECG) data was inadequate. RESULTS Fifty nine children and adolescents received a total of 77 injections of intramuscular ziprasidone for acute agitation. The mean +/- SD BARS score decreased from 6.5 +/- 0.7 to 3.1 +/- 1.3. The most common side effect was drowsiness or falling asleep (n = 46, 60%). Three (4%) could not be roused after the injection. CONCLUSIONS Intramuscular ziprasidone may be helpful for agitation but often caused oversedation. Safety data, including ECGs, is needed in controlled prospective studies.
Universal Prolongation of Linear Partial Differential Equations on Filtered Manifolds

The aim of this article is to show that systems of linear partial differential equations on filtered manifolds, which are of weighted finite type, can be canonically rewritten as first order systems of a certain type. This leads immediately to obstructions to the existence of solutions. Moreover, we will deduce that the solution space of such equations is always finite dimensional.
Hemodynamic and metabolic responses to hypergravity on a human-powered centrifuge.

INTRODUCTION Microgravity causes the deconditioning of many physiological systems, and there is great interest in developing effective countermeasures. We recently developed a short-arm human-powered centrifuge, and the primary objective of this study was to assess the hemodynamic and metabolic responses to exercise under hypergravity conditions. METHODS Phase I compared the hemodynamic and metabolic responses to 1 Gz (upright cycle ergometry) and 2 Gz conditions (Space Cycle) at the same work rate. Phase II contrasted the hemodynamic and metabolic responses at 2 and 3 Gz and at the same work rate. Phase III examined the BP and heart rate (HR) responses during passive and active centrifugation. Phase IV examined the relationship between work rate and oxygen uptake. RESULTS In Phase I, the HR and BP responses were very similar between the two Gz conditions, with the exception that 2 Gz produced a lower diastolic BP in female subjects. In Phase II, both systolic and diastolic BPs were similar under the two different Gz conditions. However, there was a significant increase in HR at 3 Gz. In Phase III, the slope of the HR/Gz relationship was greater for passive conditions, suggesting that venous return is facilitated by the skeletal muscle pump. In Phase IV, it was found that there was a highly linear relationship between work rate and oxygen uptake. CONCLUSION The results of this study demonstrate that exercise under low hypergravity conditions on the Space Cycle is well tolerated from a hemodynamic perspective.
FUNCTIONAL ACTIVITY OF HUMAN Rh MONOCLONAL ANTIBODIES (MABS)

Anti‐D and anti‐c monoclonal antibodies (MABS) were found to be heterogeneous with respect to their activity in five cell‐mediated functional assays. The two IgG3 MABS promoted greater rosette formation of red cells with monocytes than the IgG1 MABS. Discrepant results were obtained by different laboratories for the relative effectiveness of the MARS in promoting monocyte‐mediated red cell phagocytosis and lysis, which may have been due to variations in the assay methods used. The IgG3 anti‐D MAB promoted greater monocyte chemi‐luminescence than the IgG3 anti‐c MAB, but of these two MABs only the anti‐c mediated lysis of red cells in lymphocyte ADCC assays. The majority of the IgG1 anti‐r) MABS were ineffective at promoting red cell lysis by lymphocytes (K cells), but two were active even when diluted 1 in 300. There was no correlation of functional activity with red cell sensitization levels, IgG concentration or D epitope specificity of the MABS.
The Effect of Using E-Learning Tools in Online and Campus-based Classrooms on Student Performance

Creating an integrative research framework that extends a model frequently used in the Information Systems field, the Technology Acceptance Model, together with variables used in the Education field, this empirical study investigates the factors influencing student performance as reflected by their final course grade. The Technology Acceptance Model explains computer acceptance in general terms. The model measures the impact of external variables on internal beliefs, attitudes, and intentions. Perceived Usefulness and Perceived Ease of Use, two main constructs in the model, refer to an individual’s perception of how the adoption of a new technology will increase their efficiency, and the individual’s perception of how easy the technology will be to use. The lower the perceived effort is, the easier the technology will be to adopt. Thus, Perceived Usefulness, Perceived Ease of Use, Computer Self-Efficacy, and Computer Anxiety were measured to determine their effect on student performance. The proliferation of the personal computer was possible because of the applications written for it. The continuous creation of new applications has created ample ground to test the Technology Acceptance Model to determine how a user will decide to adopt such applications. The recent escalation of delivering online education via the Internet has again sparked a new dimension of information systems. This has given rise to research using the Technology Acceptance Model for applications in the Education field. Today’s modern classroom, whether online or campus-based, uses e-learning tools and Learning Management Systems that capture student cognition and engages them in the learning process via technology, while increasing their need for self-directedness. In view of this, the present study also considers the students’ ability to work independently. The results of the statistical analysis used in this study revealed marked differences in student perceptions of e-learning tools between students who chose to take an online course and students who preferred to take the campus-based section. Additionally, Perceived Usefulness, Perceived Ease of Use, and the students’ ability to work independently were all statistically significant factors in predicting students’ final grades.
Plant density in production of mini lettuce cultivars in organic system management

Production of mini vegetables in organic system is a good alternative to improve profit, but there are no researches about the optimum plant density for these cultivars in Brazilian conditions. Two experiments were conducted to evaluate the production of mini lettuce cultivars in different plant densities. Experiment 1 was conducted from January 1th (sowing) to February 10th (harvesting), 2012. The experimental design was completely randomized blocks, with six treatments in factorial scheme, 3 mini lettuce cultivars (Tudela, Renoir and Sartre) x 2 spacing between plants (16 and 20 cm), with eight replications and plots (2.04 m2) with six rows, spaced 15 cm. Experiment 2 was conducted from June 6th (sowing) to July 18th (harvesting), 2012. The cultivars Sartre and Renoir were evaluated under four plant densities (444,444; 333,333; 266,667 and 200,000 plants ha-1, corresponding to spacing of 15x15, 15x20, 25x15 and 25x20 cm, respectively). Eight treatments were defined by a factorial scheme 2 (cultivars) x 4 (plant densities) and arranged in a completely randomized block design, with nine replications and plots with 2.04 m2. The evaluated characteristics in both experiments were total and marketable fresh weight per plant, plant dry weight, plant diameter and height, marketable yield and discard percentage. In first experiment, during the summer, cultivar Sartre showed the highest marketable fresh weight (72 g plant-1). Heaviest plants (91.6 g plant-1) were obtained with the higher plant spacing, but the highest yield (2.51 kg m-2) was obtained with the smaller spacing. In winter, plants with higher total (190 g plant-1) and marketable (146 g planta-1) fresh weight were obtained with cultivar Sartre, and the same was observed in low plant density. However, the higher plant density, the higher the yield.
Hydrodynamic cell delivery for simultaneous establishment of tumor growth in mouse lung, liver and kidney

To mimic advanced stage of cancer development involving multi-organ metastasis, hydrodynamic delivery commonly used in gene transfer was explored for establishing concurrent tumors in the lung, liver and kidney using B16-F1 melanoma cells, 4T1 breast cells and Renca renal carcinoma cells, as a model. The procedure involves a rapid injection into a mouse tail-vein of serum-free medium, containing tumor cells in a volume equal to approximately 7-9% of body weight. Compared to the conventional tail vein injection of tumor cells resulting in tumor growth only in the lung, hydrodynamic injection is highly effective in establishing tumor growth in the liver, kidney and lung. All tumor cells examined including melanoma, breast metastatic, and renal carcinoma cells showed significant tumor growth in these organs. These results suggest that the hydrodynamic delivery can be a valuable tool for modeling cancer in laboratory animals, especially in experimental mice.
Laparoscopic Transumbilical Single-port Appendectomy: Initial Experience and Comparison With Three-port Appendectomy

Purpose Laparoscopic appendectomy usually needs 3 ports, 1 for the videoscope and 2 as working channels. The aim of this study was to compare the feasibility and postoperative outcomes of laparoscopic transumbilical single-port appendectomy with conventional three-port appendectomy. Methods From October 2008 to January 2009, 35 patients underwent single-port appendectomy (SA). Surgical outcomes such as operation time, number of times of parenteral analgesic injected, complication, and hospital stay of 35 patients receiving SA were analyzed and compared with those of 37 patients receiving three-port appendectomy (TA) during the same period. Results Comparing SA with TA, there were no statistically significant differences in operation time (75.9±27.4 vs. 66.4±21.7 min), times of injected analgesic (0.86±1.3 vs. 0.97±1.47 times), complication rate (8.6% vs. 2.7%), and hospital stay (3.0±1.3 vs. 3.2±1.4 d). The most common complication was wound infection (2 cases for SA and 1 for TA). One instance of intra-abdominal fluid accumulation occurred in a patient with perforated appendicitis during SA, and this was managed with image-guided drainage. In contrast to the TA, the abdominal scar in SA was nearly inconspicuous. Conclusions This study showed SA to be feasible, and it did not show any difference in postoperative outcomes compared with TA. Moreover, SA can produce scarless surgery without the need for specialized instrumentation.
The effect of obstructions and thermals in laminar-flow systems

SUMMARY The influence of obstructions and thermals on the air flow in unidirectional or laminar flow systems was studied with special reference to operating rooms. It was shown that thermals induced in the operating rooms would have little influence in the normal laminar-flow system. The importance however of obstructions such as operating lamps and personnel was shown.
Complaints of cognitive decline in the elderly: a comparison of reports by subjects and informants in a community survey

Synopsis In a community survey, subjects and their informants were asked the same questions about memory and intellectual decline in the subjects. Subjects and informants both commonly reported cognitive decline, although in most cases the decline was not seen as interfering with daily life. However, when responses from subjects and informants were cross-tabulated, agreement was found to be poor. For subjects, reports of cognitive decline were correlated with anxiety and depression symptoms and with trait neuroticism. Subjects' reports were uncorrelated with age and only weakly correlated with cognitive test performance, indicating little validity. By contrast, informants' reports were correlated with the subjects' cognitive test performance and age, but also with the informants' own anxiety and depression symptoms. Although informants' reports have validity, they may also be contaminated by the informants' affective state.
Metabolism of pravastatin sodium in isolated rat hepatocytes. II. Structure elucidation of the metabolites by n.m.r. spectroscopy.

1. The structures, including stereochemistry, of the two major metabolites of pravastatin sodium in an isolated rat hepatocyte system, i.e. the 4'a alpha-glutathione conjugate (CM-1) and the 3',5'-dihydrodiol (CM-2), were determined by one- and two-dimensional n.m. r. spectroscopy. 2. The structures of two synthetic pravastatin epoxides, possible precursors of the metabolites, were also established. 3. One of the synthetic epoxides, 4'a beta, 5' beta-epoxide was converted to the pravastatin metabolite, 4'a alpha-glutathione conjugate (CM-1) by a rat liver cytosol system and is proposed as the common metabolic intermediate between pravastatin sodium and the metabolites, CM-1 and CM-2.
On Sums of Generating Sets in ℤ2n

Let A and B be two affinely generating sets of ℤ2n. As usual, we denote their Minkowski sum by A+B. How small can A+B be, given the cardinalities of A and B? We give a tight answer to this question. Our bound is attained when both A and B are unions of cosets of a certain subgroup of ℤ2n. These cosets are arranged as Hamming balls, the smaller of which has radius 1. By similar methods, we re-prove the Freiman–Ruzsa theorem in ℤ2n, with an optimal upper bound. Denote by F(K) the maximal spanning constant |〈 A 〉|/|A| over all subsets A ⊆ ℤ2n with doubling constant |A+A|/|A| ≤ K. We explicitly calculate F(K), and in particular show that 4K/4K ≤ F(K)⋅(1+o(1)) ≤ 4K/2K. This improves the estimate F(K) = poly(K)4K, found recently by Green and Tao [17] and by Konyagin [23].
Criminal careers and life success: new findings from the Cambridge Study in Delinquent Development

The Cambridge Study in Delinquent Development is a prospective longitudinal survey of thedevelopment of offending and antisocial behaviour in 411 males first studied at age 8 in 1961 –at that time they were all living in a working-class deprived inner-city area of South London. ThisFindings describes their criminal careers up to age 50, looking at both officially recordedconvictions and self-reported offending. It also examines life success up to age 48 based on ninecriteria which were also measured on a comparable basis at age 32. The main aims were toinvestigate the development of offending and antisocial behaviour from age 10 to age 50 and theadult life adjustment of ‘persisters’, ‘desisters’ and ‘late-onset’ offenders at age 48.