Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting clonal self-renewal and extinction of hematopoietic stem cells

A single hematopoietic stem cell (HSC) can generate a clone, consisting of daughter HSCs and differentiated progeny, which can sustain the hematopoietic system of multiple hosts for a long time. At the same time, this massive expansion potential must be restrained to prevent abnormal, leukemic proliferation. We used an interdisciplinary approach, combining transplantation assays with mathematical and computational methods, to systematically analyze the proliferative potential of individual HSCs. We show that all HSC clones examined have an intrinsically limited life span. Daughter HSCs within a clone behaved synchronously in transplantation assays and eventually exhausted at the same time. These results indicate that each HSC is programmed to have a finite life span. This program and the memory of the life span of the mother HSC are inherited by all daughter HSCs. In contrast, there was extensive heterogeneity in life spans between individual HSC clones, ranging from 10 to almost 60 mo. We used model-based machine learning to develop a mathematical model that efficiently predicts the life spans of individual HSC clones on the basis of a few initial measurements of donor type cells in blood. Computer simulations predict that the probability of self-renewal decays with a logistic kinetic over the life span of a normal HSC clone. Other decay functions lead to either graft failure or leukemic proliferation. We propose that dynamical fate probabilities are a crucial condition that leads to self-limiting clonal proliferation.
TRANSCRESTAL SINUS LIFT AND IMPLANT PLACEMENT USING THE SINUS BALLOON TECHNIQUE

INTRODUCTION: Rehabilitation of the edentulous posterior maxilla with dental implants is challenging. The deficient alveolar ridge interferes with implant insertion of adequate length placed in the correct position and with the accurate inclination. The transcrestal sinus elevation procedure has become an important preprosthetic surgical procedure for bone creation in the posterior maxilla prior to implant placement. OBJECTIVES: Clinical and radiographic evaluation of using ballooning technique for sinus lift simultaneous with implant placement. MATERIALS AND METHODS: A randomized clinical trial was conducted on fourteen patients who were divided into two groups. Patients, with limited bone height below the floor of the maxillary sinus, were selected on the basis of history, clinical and radiographic examination using cone beam computed tomography. In group A, elevation of sinus membrane using ballooning technique without graft material and implants were placed simultaneously. While in group B, after sinus membrane elevation using ballooning technique, augmentation using biphasic calcium phosphate simultaneously with the implant placement were done. The bone density was measured in Hounsfield unit using ondemand3d software of the cone beam computed tomography. Also, the bone height was measured using cone beam computed tomography. RESULTS: Successful sinus membrane balloon lifting procedures were performed in 14 cases; in both groups there was no sinus membrane perforation. A total of 14 implants were placed. The radiographic examination showed the mean elevated height after 6 months by balloon in group A was 10.43 with SD ±1. 56mm.while in group B was10.31 ± 1.86. CONCLUSIONS: The use of balloon technique to elevate the sinus membrane is a minimally invasive technique and is associated with very little discomfort and complication.
Characterization of the Viscoelastic Behavior of Pharmaceutical Powders

Characterization of the Viscoelastic Behavior of Pharmaceutical Powders Barbara Jane Robinson Antonios Zavaliangos, PhD. Currently, the leading means of drug delivery is by oral administration, and tablets produced by powder compaction are the most widespread form of oral dosage. Understanding the mechanical behavior of powders allows for a rational design of complex compacts (bilayer, core in tablet, etc.). Pharmaceutical formulation development difficulties often arise during the scale up process, due to significant increase in production rate and local strain rates, when problems are the most detrimental, in terms of time and money. Viscoelasticity is one of the rate dependent characteristics of powder compaction. The main goal of this research is to evaluate the role of viscoelasticity on the powder compaction process. Current literature concerning viscoelastic behavior of powder compacts focuses on the modulus of elasticity. Equally, or even more important is the viscoelasticity of the bulk modulus, since few would argue that powder compaction is a bulk phenomenon which is not equivalent to simple tension or simple compression. Additionally, the experimental techniques used in the literature involve primarily out of die viscoelastic testing mechanisms. In die viscoelastic tests would provide a more complete explanation of the viscoelastic role in powder compaction. For the aforementioned reasons, this work is primarily focused on characterizing the viscoelastic behavior of compacts by dynamic mechanical analysis inside of a cylindrical die. This thesis includes a review of the existing literature, experimental results for Starch and MCC compacts, and some numerical simulation to support the experimental results. The results include the evaluation of the role of friction in the accuracy of the measurements, the limits of linear behavior, and the effect of relative density. Contrary to prior references in the literature the bulk modulus is viscoelastic but the corresponding dissipation factor is less than that of the Young’s modulus.
Fiji Agricultural Journal

Study of soil properties in relation to availability of important plant nutrients is vital to enhance crop productivity in Fiji. In the present study, soil samples were collected from various locations of Koronivia to determine their basic physico-chemical properties viz., pH, EC, OC, exchangeable cations, total nitrogen, available phosphorus and available potassium. Availability of important plant nutrients in relation to basic soil properties was studied. Soils were acidic in nature with an average pH value of 5.8; organic carbon (1.9%) and total nitrogen (0.15%) content were found to be very low in all the analyzed samples. The available phosphorus (16 kg ha-1) and potassium (133 kg ha-1) content were found in range of deficient to marginal in most samples. Further, pH showed a positive correlation with P and Ca and negative correlation with N. Organic carbon showed a positive correlation with N, P and Mg. Cation exchange capacity showed positive correlations with pH, P, Ca and Mg. This study suggests the necessity to apply organic manure and liming material, with appropriate nitrogenous and phosphatic fertilizer doses for enhancing farm productivity in the fields of Koronivia.
When the Air Hits Your Brain: Cerebral Autoregulation of Brain Oxygenation During Aerobic Exercise Allows Transient Hyperoxygenation Case Report

OBJECTIVECerebral autoregulation maintains a relatively stable cerebral blood flow over a range of perfusion pressures. During exercise, regional cerebral blood flow may be elevated in particular areas of the brain. This case report presents the impact of aerobic exercise on intracranially measured pressure and brain tissue oxygenation in an adult human. CLINCIAL PRESENTATIONA 30-year-old man with idiopathic intracranial hypertension treated with cerebrospinal fluid diversion was monitored with a Licox intracranial brain oxygen and pressure monitor (Integra NeuroSciences Corporation, Plainsboro, New Jersey) for refractory nonpostural headaches exacerbated after exercise. He performed trials of running and bicycling to provoke his headaches. The patient's mean intracranial pressure remained stable during exercise despite elevated cerebral perfusion pressures. Regional cerebral oxygen tension levels were strictly regulated to a level of approximately 39 mm Hg during steady state aerobic exercise, with transient increases up to 90 mm Hg at the onset and termination of activity. CONCLUSIONOur results suggest that cerebral autoregulation appears to maintain constant cerebral oxygen tension during exercise. Further, we note transient cerebral hyperoxygenation at the onset of exercise as autoregulation “turns on” and at the termination of exercise. We present a quantitative interpretation of the post-exercise hyperoxygenation phase based on Fick's principle. We are the first to demonstrate cortical hyperoxygenation in a human breathing natural air without oxygen supplementation.
Bibliometric analysis of academic output in music education in Spain

spnish jornal of peagogy yar LX X V, n . 2 6 8 , S ep em b er-D ecem b er 2 0 1 7 , 3 9 9 -4 1 4 Abstract The aim of this work is to analyse trends in music education research from Spain through bibliometric analysis of the academic output in the Web of Science database, comprising 143 articles published between 2000 and 2015. Several types of variable were analysed: a) structural variables; b) variables relating to the topic being studied; c) variables relating to the sample; and d) variable s relating to the research methods and instruments used. The results show increased representation of music education in specialised journals and a broad dissemination in journals from related areas. The data indicate that both the number of ar­ ticles on music education published and their impact are still limited when compared with other related areas. Measures are proposed to achieve a greater impact of the publications on the career development of the authors and to give the discipline a higher profile.
INVESTIGATING THE RELATIONSHIP BETWEEN THE NUTRITIONAL STATUS AND ANTHROPOMETRY IN MOTHERS OF LOW BIRTH WEIGHT DELIVERIES CONDUCTED IN TEHRAN IN 2010 AT SHAHID AKBAR ABADI HOSPITAL

INVESTIGATING THE RELATIONSHIP BETWEEN THE NUTRITIONAL STATUS AND ANTHROPOMETRY IN MOTHERS OF LOW BIRTH WEIGHT DELIVERIES CONDUCTED IN TEHRAN IN 2010 AT SHAHID AKBAR ABADI HOSPITAL Maryam Mozayeni1, Ahmad Reza Dorosty Motlagh1*, Mohammad Reza Eshraghian2, Mehdi Davaei3 1Department of Community Nutrition, School Of Nutritional Sciences And Dietetics, Tehran University of Medical Scineces 2Department of Statistics and Epidemiology, School of Health, Tehran University of Medical Sciences 3Central Unit of Tehran Azad University A R T I C L E I N F O A B S T R A C T
Environmental Information Service, Namibia for the Ministry of Environment and Tourism, the Namibian Chamber of Environment and the Namibia

s, field observations, preliminary results, new ideas and exchange of opinions, book reviews. NJE aims to create a platform for scientists, planners, developers, managers and everyone involved in promoting Namibia’s sustainable development. An Editorial Committee ensures that a high standard is maintained. ISSN: 2026-8327 (online). Articles in this journal are licensed under a Creative Commons Attribution-Non Commercial-NoDerivatives 4.0 License.
Lethal toxin from Clostridium sordellii induces apoptotic cell death by disruption of mitochondrial homeostasis in HL‐60 cells

Lethal toxin (LT) from Clostridium sordellii (strain IP82) inactivates in glucosylating the small GTPases Ras, Rap, Ral and Rac. In the present study we show that LT‐IP82 induces cell death via an intrinsic apoptotic pathway in the myeloid cell‐line HL‐60. LT‐IP82 was found to disrupt mitochondrial homeostasis as characterized by a decrease in mitochondrial transmembrane potential and cardiolipin alterations, associated with the release of cytochrome c in the cytosol. Time‐course studies of caspase activation revealed that caspase‐9 and caspase‐3 were activated before caspase‐8. Moreover, although LT‐IP82‐induced cell death was abrogated by caspase‐inhibitors, these inhibitors did not suppress mitochondrial alterations, indicating that caspase activation occurs downstream of mitochondria. Protection of mitochondria by Bcl‐2 overexpression prevented mitochondrial changes as well as apoptosis induction. Furthermore, evidence is provided that LT‐IP82‐induced apoptosis is not a consequence of cortical actin disorganization, suggesting that Rac inactivation does not initiate the apoptotic process. Cell exposure to LT‐IP82 leads to a co‐localization of the toxin with a mitochondrial marker within 2 h. Therefore, we suggest that LT‐IP82 could act at the mitochondrion level independently of its enzymatic effect on small GTPases.
[(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), a Highly Potent and Selective Agonist of the Nociceptin/Orphanin FQ Receptor

A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe4,Arg14,Lys15]N/OFQ-NH2 (UFP-102), has been generated by combining in the N/OFQ-NH2 sequence two chemical modifications, [Arg14,Lys15] and [(pF)Phe4], that have been previously demonstrated to increase potency. In vitro, UFP-102 bound with high affinity to the human NOP receptor, showed at least 200-fold selectivity over classical opioid receptors, and mimicked N/OFQ effects in CHOhNOP cells, isolated tissues from various species, and mouse cortical synaptosomes releasing 5-hydroxytryptamine. UFP-102 showed similar maximal effects but higher potency (2- to 48-fold) relative to N/OFQ. The effects of UFP-102 were sensitive to NOP-selective antagonists J-113397 [(±)-trans-1-[1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one] (pA2 = 7.75–8.12) and UFP-101 ([Nphe1,Arg14,Lys15]N/OFQ-NH2)(pA2 = 6.91–7.33) but not to naloxone, and no longer observed in tissues taken from NOP receptor knockout mice (NOP–/–). In vivo, UFP-102 (0.01–0.3 nmol i.c.v.) mimicked the pronociceptive action of N/OFQ (0.1–10 nmol i.c.v.) in the mouse tail withdrawal assay, displaying higher potency and longer lasting effects. The action of UFP-102 was not apparent in NOP–/– mice. Similar results were obtained measuring locomotor activity in mice. In conscious rats, UFP-102 (0.05 nmol i.c.v.) produced a marked and sustained decrease in heart rate, mean arterial pressure, and urinary sodium excretion and a profound increase in urine flow rate. These effects were comparable with those evoked by N/OFQ at 5 nmol. Collectively, these findings demonstrate that UFP-102 behaves as a highly potent and selective NOP receptor agonist that produces long-lasting effects in vivo.
FMM WORKING PAPER No . 24 · June , 2018 · Hans-Böckler-Stiftung DISTRIBUTION-LED GROWTH THROUGH METHODOLOGICAL LENSES

This paper presents a methodological discussion of two recent “endogeneity” critiques of the Kaleckian model and the concept of distribution-led growth. From a neo-Keynesian perspective, it is criticized because it treats distribution as quasi-exogenous, while in Skott (2017), distribution is viewed as endogenously determined by a series of (exogenous) institutional factors and social norms, and therefore one should focus on these instead of the functional distribution of income per se. The paper discusses how abstraction is used in science and economics, and uses the criteria proposed by Lawson (1989) for what constitutes an appropriate abstraction. Based on this discussion, it concludes that the criticisms are weak, although the issues raised by Skott provide some interesting directions for future work within the Kaleckian framework. ** Levy Economics Institute of Bard College. Email address: mnikifor@levy.org. A previous version of this paper was published in the Levy Economics Institute working paper series (No. 879). ————————— Distribution-led growth through methodological lenses
Breast-Feeding and Weaning Practices in the DONALD Study: Age and Time Trends

Objectives: Besides influencing short- and long-term health status, infant feeding practices are known to have an effect on later food preferences. This study aimed to identify present trends in breast-feeding duration and weaning practices with special focus on preparation methods of complementary food (CF), that is, homemade and commercial CF. Methods: In total, 1419 three-day weighed diet records collected between 2004 and 2012 from 366 children of the German DOrtmund Nutritional and Anthropometric Longitudinally Designed study ages 6 to 24 months were analysed. Full (n = 339) and total breast-feeding duration (n = 344) was collected by questionnaire. To investigate age and time trends, logistic regression and polynomial mixed regression models were used. Results: Infants born between 2008 and 2012 were 3.3-fold less likely to be fully breast-fed for ≥4 months than those born before 2004 (P < 0.0001). Overall, 59.3% commercial, 21.1% homemade, and 19.6% combined CF was consumed by the study sample. Subjects with high commercial CF consumption (percentage of commercial CF > median 62%) were significantly older (P < 0.0001), showed shorter full and total breast-feeding duration (P < 0.0001), and were more likely to have mothers with a lower educational status (P = 0.01). Both commercial and homemade CF showed opposing, nonlinear age trends. No time trends could be found. Conclusions: Decreasing duration of full breast-feeding should encourage health care providers to further promote longer breast-feeding duration. With the constantly high consumption of commercial CF at all ages, nutritional adequacy of both homemade and commercial CF needs to be investigated closer, as does their long-term influence on health and dietary habits, for example, fruit and vegetable intake.
Comprehensive Test of Accounting , Market and Hybrid Bankruptcy Prediction Models

In recent years hybrid models, using both market and accounting information, have become state of the art in predicting firm bankruptcies. However, a comprehensive test comparing their performance against alternative approaches that use either accounting or market data is missing in the literature. Using a complete database of UK Main listed firms between 1979 and 2009, our ROC curve analysis shows that the hybrid approach is superior to the alternatives. Further, our information content tests demonstrate that the hybrid models subsume all bankruptcy related information in the Taffler (1983) z-score model as well as in Bharath and Shumway (2008) contingent claims based market model. Finally, using a mixed regime competitive loan market with different costs of misclassification, the economic benefit of using the Shumway (2001) hybrid model is clear. JEL classification: C52; G33; M41
Genetic variability in maize and teosinte populations estimated by microsatellites markers

Wild species are important sources of genetic variability and may be exploited by breeding programs. Crosses between teosinte and maize occur freely and teosinte serves as genetic source of agronomic traits for introduction in maize. The objective of this study was to estimate genetic variability among and within maize and teosinte populations (Zea mays mexicana). Two sweet maize populations (BR400 and BR402), two common maize populations (Suwan and Pampa) and one teosinte population were analyzed using microsatellites markers. Results indicated that 64,5% of the variation was detected within the populations, suggesting the possibility of obtaining genetic progress by selection within each population. The analysis with 25 microsatellites loci enabled the identification of 92 alleles with a mean of 3.7 alleles per locus. The average Polymorphism Information Content (PIC) was 0.52. The percentage of polymorphic loci varied from 64% in the BR400 and Pampa populations to 80% in the teosinte population. The estimated genetic distance confirmed the genomic similarity of maize and teosinte.
Is Food Security Associated to Nutritional Status among Hospitalized Cancer and non-Cancer Patients ?

Food and nutrition are included in basic needs of humans, and their providing lies in food security term. Food insecurity has effect on individual nutritional status. In addition, appropriate nutrition status of hospitalized patients, would help preventing the complications of various treatments. Since no studies have checked the association of food security and nutritional status in hospitalized (specifically cancerous) patients, therefore this study aimed to assess the relationship between food security and nutritional status in cancer and non-cancerous patients. This crosssectional study conducted in 1390 on 240 (cancer and non-cancerous) patients from cancer institute, orthopedics, neurology and ENT (ear-nose and throat) sections of Imam Khomeini Hospital of Tehran. General characteristics, nutritional status and food security status were assessed using general, PG-SGA and USDA household food security questionnaires, respectively. Data were analyzed using chi-square and Pearson correlation coefficients tests and statistical software SPSS16.0. Percentage of moderate malnutrition (or suspected of malnutrition) and severe malnutrition were 41.7%, and 25.8%, respectively. Chi-square and Pearson correlation coefficients tests results indicated that food insecurity was significantly associated to nutritional status, so that with increasing food security score, SGA score increased (P<0.05). Because the Percentage of malnutrition in food insecure patients was more than of food secure patients, by reducing food insecurity the nutritional status of hospitalized cancer and non-cancer patients in will probably improve.
Pregnancy Diagnosis in Cattle for Fertility Management : A Review

Pregnancy diagnosis is an essential part of fertility management. Early detection of pregnancy allows early recognition and treatment of problems. The aim of this manuscript is to overview the methods of pregnancy diagnosis in cow and to highlight the advantages of pregnancy diagnosis in relation to fertility management. Methods of pregnancy diagnosis in cow can be classified into direct and indirect methods. Direct methods of pregnancy diagnosis include transrectal palpation and ultrasonography. Indirect methods for early pregnancy diagnosis include measurement of endocrine hormones and pregnancy specific proteins. Visual method is far from perfect. Detecting animals that have been inseminated returning to heat is the most cost-effective method of early detection of non-pregnancy. However, it cannot be relied on as a method of pregnancy detection as a high proportion of cattle (often>30%) which are not seen in heat are actually empty. Transrectal palpation and ultrasonography continue to be the methods of choice for an accurate and early pregnancy diagnosis. Transrectal palpation remains the method of choice for early pregnancy diagnosis. Ultrasound examination is better for aging and sexing the embryo. An accurate, early diagnosis of pregnancy is essential to a successful breeding program. In both beef and dairy cattle, pregnancy diagnosis is an important tool to measure the success of a reproductive management, to allow for early detection of problems and to achieve resynchronization of non-pregnant cows. Generally Pregnancy diagnosis is an important part of good management and helps to maximize reproductive performance. Therefore, the veterinarians and animal production workers should develop an awareness creation about the importance of early pregnancy diagnosis for the farmers and the government should build national laboratories and research centers to provide pregnancy testing for the farmers as a valuable tool for fertility management.