Miracle-dz/UniFAR-FTUs huggingface dataset:
Physical activity beliefs and behaviour of adults with physical disabilities

Purpose. The purpose of this study was to elicit the physical activity (PA) beliefs from adults with physical disabilities; and second, to examine their self-reported PA participation. Method. Participants were 223 adults (M age = 45.4 years, SD = 10.8), with self-reported physical disabilities who completed a web-based survey. Six open-ended questions were used to assess PA beliefs and the PA Scale for Individuals with Physical Disabilities measured self-reported PA. Results. A qualitative analysis showed that the most accessible behavioural advantages are that PA improves emotional functioning and assists with weight management. The most accessible behavioural disadvantages are that PA causes pain or soreness and consumes time. The most accessible normative influences that approve of PA are family, friends, and healthcare professionals. The most accessible control beliefs obstructing PA are disability and associated symptoms, and a lack of access to adequate facilities, equipment, or programs. The most accessible control beliefs that facilitate PA are access to adequate facilities, equipment, or programs, and support or assistance. Finally, the average total PA score was 20.5 metabolic equivalent (METS)-hours/day (SD = 16.8). Conclusions. Adults with physical disabilities possess unique PA beliefs that can be used to design health promotion interventions to increase PA participation.
Analytic and Algorithmic Methods for Computing the Space Requirements of Stream Monitor Specifications

In previous work “Better Space Bounds for Future-Looking Stream Monitors”, upper bounds were derived for the space requirements of monitoring steam specifications in the LogicGuard specification language. The analysis was based on the assumption that in these formulas quantifiers can be arbitrarily nested, but in the body of each quantifier there is at most one quantifier; we refer to such formulas as quantifier vectors. While analytic results for two special classes of quantifier vectors were derived, bounds for the space requirements of arbitrary quantifier vectors remained unresolved. In this work, we show how to generalize our previous results in order to derive bounds for any quantifier vector. Based on this generalization, we give an algorithm which can compute space bounds for the full specification language.
Acquisition of locative meanings: behind and in front of

ABSTRACT Studies of locatives suggest regularities in order and age of acquisition, including systematic changes in context of use for behind and in front of. The present investigation extends earlier work by utilizing more naturalistic elicitation procedures and exploring an early use of behind and in front of with large reference objects. Thirty-three children, ages 2; 7 to 4; 7, told puppets where to look for missing objects. Results indicate an order of acquisition for English locatives which is consistent with prior reports. However, the puppet story method elicited given locatives at younger ages, and the first uses of behind occurred with large, non-featured reference objects. The patterns of use for behind and in front of suggest an acquisition process in which new conceptual resources lead to the re-analysis of object configurations and thus to new aspects of meaning.
Quality Report Cards, Selection of Cardiac Surgeons, and Racial Disparities: A Study of the Publication of the New York State Cardiac Surgery Reports

Quality report cards have become common in many health care markets. This study evaluates their effectiveness by examining the impact of the New York State (NYS) Cardiac Surgery Reports on selection of cardiac surgeons. The analyses compares selection of surgeons in 1991 (pre-report publication) and 1992 (post-report publication). We find that the information about a surgeon's quality published in the reports influences selection directly and diminishes the importance of surgeon experience and price as signals for quality. Furthermore, selection of surgeons for black patients is as sensitive to the published information as is the selection for white patients.
Climate change and human colonization triggered habitat loss and fragmentation in Madagascar

The relative effect of past climate fluctuations and anthropogenic activities on current biome distribution is subject to increasing attention, notably in biodiversity hot spots. In Madagascar, where humans arrived in the last ~4 to 5,000 years, the exact causes of the demise of large vertebrates that cohabited with humans are yet unclear. The prevailing narrative holds that Madagascar was covered with forest before human arrival and that the expansion of grasslands was the result of human‐driven deforestation. However, recent studies have shown that vegetation and fauna structure substantially fluctuated during the Holocene. Here, we study the Holocene history of habitat fragmentation in the north of Madagascar using a population genetics approach. To do so, we infer the demographic history of two northern Madagascar neighbouring, congeneric and critically endangered forest dwelling lemur species—Propithecus tattersalli and Propithecus perrieri—using population genetic analyses. Our results highlight the necessity to consider population structure and changes in connectivity in demographic history inferences. We show that both species underwent demographic fluctuations which most likely occurred after the mid‐Holocene transition. While mid‐Holocene climate change probably triggered major demographic changes in the two lemur species range and connectivity, human settlements that expanded over the last four millennia in northern Madagascar likely played a role in the loss and fragmentation of the forest cover.
Listening to the voices: an exploratory study of the experiences of women diagnosed and living with breast cancer in Uganda

Introduction Breast cancer is one of the leading causes of cancer deaths amongst Ugandan women. Most women live through challenging and emotional experiences having been diagnosed with breast cancer. The purpose of this study was to explore the lived experiences of women diagnosed and living with breast cancer. Methods This was an exploratory qualitative study using a convenience sample (n = 12) of women confirmed with breast cancer and reporting to the Radiology department for imaging. In-depth individual interviews were conducted and findings were summarized into themes, representative of the participants’ lived experiences. Results All women in this study initially went through emotional trauma of living with breast cancer. However, with time, they seemed to accept and cope with their situation. Four major themes summarizing their experiences included: Thought of Death, Strength to live, Loss of female identity and sexuality and Coping mechanisms. Conclusion This study provided a unique insight of the experiences of women living with breast cancer. By listening to their narratives, one could see emotional pain, anger, anxiety, strength to live and many more. Although women with breast cancer get clinical management, there is need to design holistic palliative healthcare services including counseling to assist then cope with life.
Proteomic analysis of cell surface proteins from Clostridium difficile

Clostridium difficile is a bacterium that causes disease of the large intestine, particularly after treatment with antibiotics. The bacterium produces two toxins (A and B) that are responsible for the pathology of the disease. In addition, a number of bacterial virulence factors associated with adhesion to the gut have previously been identified, including the cell wall protein Cwp66, the high‐molecular weight surface layer protein (HMW‐SLP) and the flagella. As the genome sequence predicts many other cell wall associated proteins, we have investigated the diversity of proteins in cell wall extracts, with the aim of identifying further virulence factors. We have used a number of methods to remove the proteins associated with the cell wall of C. difficile. Two of the resulting extracts, obtained using low pH glycine treatment and lysozyme digestion of the cell wall, have been analysed in detail by two‐dimensional electrophoresis and mass spectrometry. One hundred and nineteen spots, comprising 49 different proteins, have been identified. The two surface layer proteins (SLPs) are the most abundant proteins, and we have also found components of the flagellum. Interestingly, we have also determined that a number of paralogs of the HMW‐SLP are expressed, and these could represent targets for further investigation as virulence factors.
Trait anxiety mediates the link between inferior frontal cortex volume and negative affective bias in healthy adults

Abstract Anxious individuals tend to show a negative affective bias in attention that likely reflects reduced executive control, a cognitive function associated with the inferior frontal cortex (IFC), particularly its posterior segment, pars opercularis. Here, we investigated the relations among gray matter volume in the pars opercularis of IFC, trait anxiety, and negative biases in attention, in healthy participants. Sixty-two adults underwent structural magnetic resonance imaging scanning, completed a trait anxiety measure, and performed an Affective Go/No-Go (AGN) task. IFC volumes were extracted using Freesurfer, and negative bias scores were calculated from AGN performance. Trait anxiety correlated negatively with left IFC volume, and positively with the negative bias in reaction time. Furthermore, trait anxiety mediated the negative relation between the IFC volume and the negative bias measure. Overall, the present findings extend previous understanding of the IFC involvement in anxiety at the structural level, and may inform the development of intervention programs targeting anxiety.
Human T-Cell Leukemia Virus Type 2 Tax Mutants That Selectively Abrogate NF k B or CREB/ATF Activation Fail To Transform Primary Human T Cells

Human T-cell leukemia virus (HTLV) Tax protein has been implicated in the HTLV oncogenic process, primarily due to its pleiotropic effects on cellular genes involved in growth regulation and cell cycle control. To date, several approaches attempting to correlate Tax activation of the CREB/activating transcription factor (ATF) or NF k B/Rel transcriptional activation pathway to cellular transformation have yielded conﬂicting results. In this study, we use a unique HTLV-2 provirus (HTLV c-enh ) that replicates by a Tax-independent mechanism to directly assess the role of Tax transactivation in HTLV-mediated T-lymphocyte transformation. A panel of well-characterized tax-2 mutations is utilized to correlate the respective roles of the CREB/ATF or NF k B/Rel signaling pathway. Our results demonstrate that viruses expressing tax-2 mutations that selectively abrogate NF k B/Rel or CREB/ATF activation display distinct phenotypes but ultimately fail to transform primary human T lymphocytes. One conclusion consistent with our results is that the activation of NF k B/Rel provides a critical proliferative signal early in the cellular transformation process, whereas CREB/ATF activation is required to ﬁrst the ability of the mutant viruses to efﬁciently replicate. In this study, we examined the effects of select Tax-2 mutants on the ability of HTLV-2 to transform human T lym- phocytes. In our study, transformation is deﬁned as continuous growth in culture in the absence of exogenous IL-2. Our results indicate that viruses expressing tax mutants that selectively abrogate NF k B/Rel or CREB/ATF fail to induce IL-2-inde-pendent T-lymphocyte transformation. Our results suggest that activation of NF k B/Rel provides a critical proliferative signal early in the cellular transformation process, whereas CREB/ ATF activation promotes sustained cell growth and IL-2-inde-pendent cellular transformation. anti-
NUMERICAL FLOW ANALYSIS FOR SPILLWAYS

Many dam structures in Australia were designed and built in the 1950s and 60s with limited hydrological information. As a result existing spillway structures are under-sized for today’s revised probable maximum floods (PMF). Potential problems such as the generation of excessive negative pressure over spillway crest under increased flood condition could be encountered. This may cause instability or cavitation damage to the spillway. The raised flow profile may also have adverse impacts on crest bridges and gate structures. Historically, physical models have been constructed in hydraulic laboratories to study these behaviours, but they are expensive, time-consuming and there are many difficulties associated with scaling effects. Today, with the use of high-performance computers and more efficient computational fluid dynamics (CFD) codes, the behaviour of hydraulic structures can be investigated numerically in reasonable time and expense. This paper describes the twoand three-dimensional CFD modelling of spillway behaviour under rising flood levels. The results have been validated against published data and good agreement was obtained. The technique has been applied to investigate several spillway structures in Australia.
CD44H expression in reactive mesothelium, pleural mesothelioma and pulmonary adenocarcinoma

Malignant mesotheliomas are known to produce hyaluronic acid, in contrast to most pulmonary adenocarcinomas which produce neutral mucin. CD44H is the major cell surface receptor for hyaluronic acid. The aim of this study was to investigate immunohistochemically the expression of this antigen in reactive mesothelium, pleural mesothelioma and pulmonary adenocarcinoma and to assess its diagnostic utility in distinguishing the two tumours. Diffuse and intense membranous CD44H immunoreactivity was seen in 15 of 20 (75%) mesotheliomas and in all 20 biopsies of reactive mesothelium. In contrast, focal (<10% tumour) expression of CD44H was seen in only three of 20 (15%) pulmonary adenocarcinomas. We advocate the use of CD44H as a positive mesothelial marker for incorporation alongside other established immunohistochemical markers used to distinguish mesothelioma from adenocarcinoma.
A Nationwide Epidemiologic Modeling Study of LD

Through multiple logistic regression modeling, this article explores the relative importance of risk and protective factors associated with learning disabilities (LD). A representative national sample of 6- to 17-year-old students (N = 1,268) was drawn by random stratification and classified by the presence versus absence of LD in reading, spelling, and mathematics according to ability—achievement discrepancies or low achievement levels. The dichotomous classifications were regressed on sets of explanatory variables indicating potential biological, social—environmental, and cognitive factors, problem behavior, and classroom learning behavior. Modeling revealed patterns of high risk for male students and students evincing verbal and nonverbal ability problems and processing speed problems. It was shown that, absent controls for cognitive abilities (such as provided by the ability—achievement discrepancy definition), definitions keyed to low achievement will substantially overidentify ethnic minority and disadvantaged students and will be confounded by significantly higher proportions of students who display oppositional and aggressive behavior problems. Alternatively, good learning behaviors uniformly provide substantial reduction in the risk for LD.
MACROECONOMIC ISSUES IN SMALL STATES AND IMPLICATIONS FOR FUND ENGAGEMENT

A deterioration in small states’ relative macroeconomic performance since the late 1990s warrants a fresh look at their common challenges and at how the Fund can best engage with them. Small states have performed reasonably well over an extended period, with per capita income levels and social indicators that are broadly in line with those of their larger comparators. However, despite prolonged policy efforts, they have not shared in the improved economic growth of larger peers since the late 1990s, and also continue to experience relatively high levels of macroeconomic volatility. Macroeconomic challenges are particularly marked for the smallest (or “micro”) states. Based on common characteristics, this paper attempts to provide a comprehensive framework for examining the growth-related and other challenges of small states.
Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits.

BACKGROUND Thrombin may have a pivotal role in restenosis after angioplasty. Hirudin, a potent thrombin inhibitor, reduces luminal narrowing by plaque after angioplasty in a rabbit model of atherosclerosis. Because cellular proliferation is believed to be an important mechanism for restenosis and thrombin has been shown to be a potent smooth muscle cell mitogen in vitro, we hypothesized that the mechanism of the effect of hirudin on limiting luminal narrowing by plaque occurs via inhibition of cellular proliferation. METHODS AND RESULTS Femoral atherosclerosis was induced in 108 rabbits, and balloon angioplasty was performed. At angioplasty, group 1 rabbits (n=38) were treated with a 2-hour infusion of hirudin, and group 2 rabbits (n=41) were treated with heparin. Group 3 rabbits (n=29) were treated with hirudin (n=15) or heparin (n=14) and killed at 7 or 28 days to determine cross-sectional area narrowing by plaque and cellular proliferation with the use of bromodeoxyuridine labeling. At 29, 71, or 167 hours after angioplasty, group 1 and 2 rabbits were injected with 3H-thymidine and killed 1 hour later, and labeling indexes were determined. A significant increase in the index of 3H-thymidine-labeled nuclei was observed in the intima of "ballooned" arteries compared with "nonballooned" atherosclerotic arteries at both 30 hours (0.06+/-0.05 versus 0.01+/-0.01, P<.01) and 72 hours (0.10+/-0.06 versus 0.004+/-0.004, P<.01). By 7 days, the index of labeled cells was similar to baseline (0.04+/-0.03 versus 0.01+/-0.01, P=.12). Hirudin had no effect on the 3H-thymidine labeling indexes at any of the time points studied despite the fact that hirudin treatment in group 3 rabbits resulted in less cross-sectional area narrowing by plaque at both 7 and 28 days after angioplasty (41+/-16 versus 24+/-12 at 7 days and 60+/-21 versus 44+/-17 at 28 days, heparin versus hirudin; P<.03). CONCLUSIONS Balloon angioplasty resulted in a marked increase in cellular proliferation that peaked at 72 hours. A 2-hour infusion of hirudin failed to reduce early 3H-thymidine labeling, suggesting that inhibition of cell proliferation within the first 7 days after angioplasty is not the predominant mechanism by which hirudin exerts its effect on limiting luminal narrowing by plaque 28 days after balloon angioplasty in this animal model.
Treatment of Refractory Persistent Corneal Epithelial Defects: A Standardized Approach Using Continuous Wear PROSE Therapy

Abstract Purpose: To evaluate continuous wear of a fluid-ventilated, gas-permeable scleral PROSE device using a standardized protocol as treatment for refractory persistent corneal epithelial defects in patients with severe ocular surface disease. Methods: Retrospective review of eight eyes of seven consecutive patients with persistent epithelial defects refractory to traditional therapies. The standardized treatment regimen consisted of: (1) 24-hour-a-day PROSE wear until re-epithelialization was achieved, (2) brief daily device removal, cleaning, disinfection, and reservoir fluid replacement, (3) addition of a benzalkonium chloride (BAK)-free fourth-generation fluoroquinolone antibiotic drop to the reservoir, and (4) transition to long-term, daytime PROSE wear upon re-epithelialization. Results: All eight eyes exhibited resolution of the persistent epithelial defect. No eyes developed microbial keratitis. Four eyes exhibited recurrences; all recurrences promptly responded to reinstitution of continuous wear. Conclusions: Continuous wear of a PROSE device, using a strictly standardized regimen, constitutes an effective, safe treatment option for refractory persistent epithelial defects.
Complement Activation and Cardiovascular Disease

The mechanisms by which tissue injury after acute myocardial infarction occurs have not been fully elucidated, but considerable evidence suggests that activation of complement plays an important role in the pathophysiology. Reperfusion of the ischemic myocardium is strictly necessary to rescue the exposed tissue from eventual death. However, reversion of the blood supply is also associated with reperfusion injury contributing to tissue injury. Activation of the complement system has indisputable beneficial effects in the immune defense and in the clearance of damaged tissue and apoptotic cells, but excessive activation of the system may lead to uncontrolled tissue damage. This review focuses on the role of complement activation, with focus on the lectin pathway, endothelial dysfunction and cardiovascular diseases, including ischemic heart disease and diabetic angiopathy. Finally, potential therapeutic strategies targeting the complement system are discussed.
Comparison of self-collected vaginal, vulvar and urine samples with physician-collected cervical samples for human papillomavirus testing to detect high-grade squamous intraepithelial lesions.

BACKGROUND Certain types of human papillomavirus (HPV) in cervical samples are strongly associated with squamous intraepithelial lesions (SIL) and invasive cervical carcinoma. We determined and compared the test characteristics of testing for HPV with samples obtained by patients and with samples obtained by their physicians. METHODS In a consecutive series of women referred to a colposcopy clinic at a teaching hospital because of abnormalities on cervical cytologic screening, 200 agreed to collect vulvar, vaginal and urine samples for HPV testing. The physician then collected cervical samples for HPV testing, and colposcopy, with biopsy as indicated, was performed. Presence of HPV was evaluated using the hybrid capture II assay (Digene Corp., Silver Spring, Md.) with a probe cocktail for 13 carcinogenic types. Cervical specimens were also tested for HPV by polymerase chain reaction and hybridization with type-specific probes. Cervical smears for cytologic examination were obtained from all women. RESULTS High-grade lesions (high-grade squamous intraepithelial lesions [HSIL], equivalent to cervical intraepithelial neoplasia [CIN] grade 2 or 3, and adenocarcinoma) were found in 58 (29.0%) of the 200 women. Carcinogenic types of HPV were detected in the self-collected vaginal samples of 50 (86.2%) of these 58 women, in the self-collected vulvar samples of 36 (62.1%) and in the self-collected urine samples of 26 (44.8%). Carcinogenic types of HPV were detected in the cervical samples collected by physicians for 57 (98.3%) of these 58 women. The remaining 142 women (71.0%) had normal findings or low-grade squamous intraepithelial lesions (LSIL, CIN grade 1). Test results were negative or noncarcinogenic types of HPV were detected in the self-collected vaginal samples of 76 (53.5%) of these 142 women, in the self-collected vulvar samples of 89 (62.7%) and in the self-collected urine samples of 99 (69.7%). The sensitivity for self-collected samples ranged from 44.8% to 86.2%, and the specificity from 53.5% to 69.7%. For the samples collected by physicians, the sensitivity was 98.3% and the specificity 52.1%. The self-sampling methods were generally acceptable to the women: 98.4% of respondents (126/128) deemed urine sampling acceptable, 92.9% (118/127) found vulvar sampling acceptable, and 88.2% (112/127) found vaginal sampling acceptable. INTERPRETATION Self-collection of samples for HPV testing was acceptable to women attending a colposcopy clinic for investigation of suspected cervical lesions and shows sufficient sensitivity to warrant further evaluation as a screening test for cervical cancer prevention programs.