Miracle-dz/UniFAR-FTUs huggingface dataset:
Smart city — Model of sustainable development of cities

The development of the Internet has enabled interconnection of products, services and people into one unit by means of so called Internet of Things. Technologies like the Internet, transfer of information, data processing and booming development in electronics and informatics make it possible to create a completely different picture of our towns and to create a phenomenon of recent years — Smart City. A psychological impact on people is highly important. What to do so that people change their behavior and begin to behave responsibly to the environment? The sharing economy is a concept of social changes of people in the 21st century who do not need to own the things of daily use and, thanks to the existing offer of various communication tools, are able to make use of joint products. In our contribution, we will sketch out economy of car sharing, bicycle sharing, public transport and possibilities of using these systems in our consumer society. What possibilities of influencing behavior of road users traffic psychology has.
Cajanus cajan (cv. C11): An Important Non-Host Resource for Proteinase Inhibitors Active against Larval Midgut Proteinases of Lepidopteran Insect Pest Achaea janata

Our previous studies indicated that seeds of various cultivars and wild relatives of pigeonpea possessed proteinase inhibitors (PIs) which were active against midgut trypsin-like proteinases of lepidopteran insects. In the present study a detailed analysis of PIs distribution in mature seeds of five different cultivars of Cajanus cajan and thirteen different accessions of Cajanus platycarpus was carried out. Further the inhibitory potential of these PIs against larval midgut trypsin-like proteinases of Achaea janata was also evaluated. Among the chosen cultivars and C. platycarpus accessions, the cultivar ‘ICP 7118’ also called as ‘C11’ showed highest inhibitory potential against A. janata larval midgut trypsin-like proteinases (AJPs). The inhibitory potential of PIs from ‘C11’ was 25 and 106 fold higher against AJPs, compared to bovine pancreatic trypsin and chymotrypsin, respectively. Further, the activity profile of PIs of ‘C11’ on gelatin-polyacrylamide gel demonstrated the presence of higher number of trypsin inhibitor isoforms as well as stronger inhibitory potential against AJPs, when compared with C. platycarpus accessions. Thus, the results from the present investigation confirmed that the cultivar ‘C11’ of C. cajan is the best non-host resource for PIs active against AJPs and these PIs can be readily exploited further as ecofriendly pesticide in the management of this non-host lepidopteran insect pest A. janata using transgenic technology.
NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS

Astrocytes are involved in non‐cell‐autonomous pathogenic cascades in amyotrophic lateral sclerosis (ALS); however, their role is still debated. We show that astrocytic NF‐κB activation drives microglial proliferation and leukocyte infiltration in the SOD1 (G93A) ALS model. This response prolongs the presymptomatic phase, delaying muscle denervation and decreasing disease burden, but turns detrimental in the symptomatic phase, accelerating disease progression. The transition corresponds to a shift in the microglial phenotype showing two effects that can be dissociated by temporally controlling NF‐κB activation. While NF‐κB activation in astrocytes induced a Wnt‐dependent microglial proliferation in the presymptomatic phase with neuroprotective effects on motoneurons, in later stage, astrocyte NF‐κB‐dependent microglial activation caused an accelerated disease progression. Notably, suppression of the early microglial response by CB2R agonists had acute detrimental effects. These data identify astrocytes as important regulators of microglia expansion and immune response. Therefore, stage‐dependent microglia modulation may be an effective therapeutic strategy in ALS.
Revealing the Dynamic Modulations That Underpin a Resilient Neural Network for Semantic Cognition: An fMRI Investigation in Patients With Anterior Temporal Lobe Resection

Abstract One critical feature of any well-engineered system is its resilience to perturbation and minor damage. The purpose of the current study was to investigate how resilience is achieved in higher cognitive systems, which we explored through the domain of semantic cognition. Convergent evidence implicates the bilateral anterior temporal lobes (ATLs) as a conceptual knowledge hub. While bilateral damage to this region produces profound semantic impairment, unilateral atrophy/resection or transient perturbation has a limited effect. Two neural mechanisms might underpin this resilience to unilateral ATL damage: 1) the undamaged ATL upregulates its activation in order to compensate; and/or 2) prefrontal regions involved in control of semantic retrieval upregulate to compensate for the impoverished semantic representations that follow from ATL damage. To test these possibilities, 34 postsurgical temporal lobe epilepsy patients and 20 age-matched controls were scanned whilst completing semantic tasks. Pictorial tasks, which produced bilateral frontal and temporal activation, showed few activation differences between patients and control participants. Written word tasks, however, produced a left-lateralized activation pattern and greater differences between the groups. Patients with right ATL resection increased activation in left inferior frontal gyrus (IFG). Patients with left ATL resection upregulated both the right ATL and right IFG. Consistent with recent computational models, these results indicate that 1) written word semantic processing in patients with ATL resection is supported by upregulation of semantic knowledge and control regions, principally in the undamaged hemisphere, and 2) pictorial semantic processing is less affected, presumably because it draws on a more bilateral network.
Ameliorative effects of Embilica officinalis and Rosmarinus officinalis on cadmium-induced oxidative stress in Wistar rats

The study was designed to assess the antioxidative potential of three dietary antioxidants, vitamin C, Rosemary (Rosmarinus officinalis) leaf extract (10% carnosic acid) and Amla ( Embilica officinalis ) fruit extract (aqueous) on cadmium-induced oxidative stress and the related histopathology of the liver and kidney of Wistar rats. Cadmium was administered as cadmium chloride (15 mg/kg body weight/day) for 4 weeks with five groups co-treated with the antioxidants, vitamin C (100 mg/kg/day) Rosemary leaf extract (15 and 30 mg/kg/day) and amla fruit extract (100 and 200 mg/kg/day). The results showed that cadmium induced a significant increase in both kidney and liver malondialdeyhde (MDA) levels coupled with an inhibition of the superoxide dismutase (SOD) and catalase (CAT) activity. Co-treatment of cadmium and the antioxidants did alleviate the oxidative stress which was observed as a significant reduction in the MDA levels and an increase in the SOD activity both in the kidney and liver. CAT activity was only increased by vitamin C and Rosemary (15 mg/kg) co-treatment in the kidney. Furthermore, cadmium induced cellular disorganization of the kidney and liver was restored with the co-treatment of the antioxidants being more pronounced with the plant extracts. Rosemary leaf extract was efficacious at both the doses while the amla fruit extract had the most ameliorative effect at a higher dose (200 mg/kg).
The importance of ecological memory for trophic rewilding as an ecosystem restoration approach

Increasing human pressure on strongly defaunated ecosystems is characteristic of the Anthropocene and calls for proactive restoration approaches that promote self‐sustaining, functioning ecosystems. However, the suitability of novel restoration concepts such as trophic rewilding is still under discussion given fragmentary empirical data and limited theory development. Here, we develop a theoretical framework that integrates the concept of ‘ecological memory’ into trophic rewilding. The ecological memory of an ecosystem is defined as an ecosystem's accumulated abiotic and biotic material and information legacies from past dynamics. By summarising existing knowledge about the ecological effects of megafauna extinction and rewilding across a large range of spatial and temporal scales, we identify two key drivers of ecosystem responses to trophic rewilding: (i) impact potential of (re)introduced megafauna, and (ii) ecological memory characterising the focal ecosystem. The impact potential of (re)introduced megafauna species can be estimated from species properties such as lifetime per capita engineering capacity, population density, home range size and niche overlap with resident species. The importance of ecological memory characterising the focal ecosystem depends on (i) the absolute time since megafauna loss, (ii) the speed of abiotic and biotic turnover, (iii) the strength of species interactions characterising the focal ecosystem, and (iv) the compensatory capacity of surrounding source ecosystems. These properties related to the focal and surrounding ecosystems mediate material and information legacies (its ecological memory) and modulate the net ecosystem impact of (re)introduced megafauna species. We provide practical advice about how to quantify all these properties while highlighting the strong link between ecological memory and historically contingent ecosystem trajectories. With this newly established ecological memory–rewilding framework, we hope to guide future empirical studies that investigate the ecological effects of trophic rewilding and other ecosystem‐restoration approaches. The proposed integrated conceptual framework should also assist managers and decision makers to anticipate the possible trajectories of ecosystem dynamics after restoration actions and to weigh plausible alternatives. This will help practitioners to develop adaptive management strategies for trophic rewilding that could facilitate sustainable management of functioning ecosystems in an increasingly human‐dominated world.
Impaired Prefrontal Cortical Dopamine Release in Schizophrenia During a Cognitive Task: A [11C]FLB 457 Positron Emission Tomography Study

Evidence from several lines of research suggests decreased dopamine release in the prefrontal cortex as the neurochemical correlates of cognitive deficits in schizophrenia (SCZ). However, in vivo examination of cortical hypodopaminergia using positron emission tomography (PET) during cognitive task performance in SCZ remains to be investigated. We examined dopamine release in anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC), using PET while participants were performing a cognitive task. Thirteen drug-free patients with SCZ and 13 healthy volunteers (HV) matched for age and sex participated in the study. Data were acquired between 2011 and 2015. Two PET scans with [11C]FLB 457 were acquired while the participants were performing the Wisconsin Card Sorting Test (WCST) and a sensorimotor control task (SMCT). A magnetic resonance image was acquired for anatomical delineation. Differences in cortical dopamine release between SCZ and HV, indexed as percentage change in binding potential between WCST and SMCT (ΔBPND), were calculated in ACC and DLPFC. We observed significant differences in the ΔBPND in ACC (HV = 4.40 ± 6.00; SCZ = -11.48 ± 15.08; t = 3.52; P = .003) and a trend-level difference in ΔBPND in DLPFC (HV = -0.58 ± 8.45; SCZ = -7.79 ± 11.28; t = 1.84; P = .079), suggesting dopamine depletion in cortical brain regions in patients with SCZ while performing a cognitive task. These results provide the first in vivo evidence for reduced dopamine release or even dopamine depletion while performing cognitive task in ACC and DLPFC in patients with SCZ. The present results provide support for the frontal hypodopaminergia hypothesis of cognitive symptoms in SCZ.
Big data implementation for small and medium enterprises

Big data provides an opportunity for organizations to gain insights from their data in order to make better decision. Large companies in several sectors are achieving enormous improvements by applying big data analytics. Small and medium enterprises (SMEs), which have smaller size and less revenue, can also benefit from big data to add value to their business. This paper presents the capabilities, readiness, and challenges for SMEs to implement big data. The qualitative research is conducted by observation and interview of 40 SMEs whose businesses are in service or production sector in Thailand. According to the analysis, SMEs are divided into three categories, and the approach for implementing big data is proposed considering these categories. The results can be a guideline for big data implementation for SMEs to achieve competitive advantages.
Active approach for breast cancer genetic counseling during radiotherapy : long-term psychosocial and medical impact

Genetic counseling and DNA testing (GCT) for breast cancer is increasingly being actively offered to newly diagnosed patients. Little is known about the consequences of such an approach. Therefore, the long-term psychosocial and medical impact of referring breast cancer patients for GCT during an early phase of treatment was studied. A group of 112 breast cancer patients who had been actively offered GCT during adjuvant radiotherapy 7–14 years earlier, returned a self-report questionnaire. We compared their experiences with a group of 127 breast cancer patients who had not met the criteria for GCT. In total, 239 women participated in this long-term follow-up study (72% response rate). Nearly 75% of them had received regular mammography surveillance in the past 3 years. Preventive surgery was reported more often in the counseling group (specifically in the BRCA1/2 mutation carriers). Like the comparative group, only a minority of patients who had received GCT were experiencing high levels of depression (5%) or psychological distress (14%). Breast cancer patients can be actively approached and referred for GCT at the beginning of their radiotherapy without a threat to psychological functioning in the long term.
Semiparametric Sieve-Type Generalized Least Squares Inference

This article considers the problem of statistical inference in linear regression models with dependent errors. A sieve-type generalized least squares (GLS) procedure is proposed based on an autoregressive approximation to the generating mechanism of the errors. The asymptotic properties of the sieve-type GLS estimator are established under general conditions, including mixingale-type conditions as well as conditions which allow for long-range dependence in the stochastic regressors and/or the errors. A Monte Carlo study examines the finite-sample properties of the method for testing regression hypotheses.
The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer

Since seminal descriptions of signal transducer and activator of transcription 3 (STAT3) as a signal transducer and transcriptional regulator, which is most usually activated by phosphorylation of a specific tyrosine residue, a staggering wealth of research has delineated the key role of this transcription factor as a mediator of mammary gland postlactational regression (involution), and paradoxically, a pro-survival factor in breast cancer and some breast cancer cell lines. STAT3 is a critical regulator of lysosomal-mediated programmed cell death (LM-PCD) during mammary gland involution, where uptake of milk fat globules, and consequent high levels of free fatty acids, cause permeabilisation of lysosomal vesicle membranes, in turn leading to cathepsin protease leakage and cell death. A recent proteomic screen of STAT3-induced changes in lysosomal membrane protein components has highlighted wide-ranging effects of STAT3, which may coordinate LM-PCD via the stimulation of endocytosis, intracellular trafficking, and lysosome biogenesis. In parallel, STAT3 regulates the acute phase response during the first phase of involution, and it contributes to shaping the pro-tumourigenic ‘wound healing’ signature of the gland during the second phase of this process. STAT3 activation during involution is important across species, although some differences exist in the progression of involution in dairy cows. In breast cancer, a number of upstream regulators can lead to STAT3 activation and the effects of phosphorylation of STAT3 are equally wide-ranging. Recent studies have implicated microRNAs in some regulatory pathways. In this review, we will examine the multifaceted role of STAT3 in mammary gland involution and tumourigenesis, incorporating a review of these fundamental processes in tandem with a discussion of recent developments in this field.
Effects of straw return on bacterial communities in a wheat-maize rotation system in the North China Plain

Straw return plays an important role in reducing the use of chemical fertilizer, promoting soil carbon sequestration, thus maintaining soil fertility and alleviating environmental pollution. To examine the effects of straw return on soil bacterial communities, quantitative PCR and high-throughput sequencing approaches were used to analyze the bacterial abundance and community structures at the depths of 5–25 cm and 25–45 cm in the soils under six-year continuous straw return and removal treatments in Langfang, Hebei, the North China Plain. As a result, straw return had no effects on soil chemical properties, bacterial abundance, richness or diversity at both soil depths. In contrast, vertical distributions of available nitrogen and available potassium were affected. Similarly, straw return also changed the vertical distributions of Proteobacteria and Chloroflexi. Principal coordinate analysis based on weighted UniFrac distance matrix indicated a moderate separation of the bacterial community in the soil treated with straw return from that with straw removal at 5–25 cm depth, but they were not distinctly distinguished at 25–45 cm depth. T-test identified increased abundance of Candidatus Latescibacteria in the soil under straw return treatment at 5–25 cm depth but no differentially abundant phyla at 25–45 cm depth was found. These results suggested a selection effect from the six-year continuous straw return treatment and the soil bacterial communities were moderately changed.
Coupling Substrate-Integrated Waveguides to Increase the Gain Bandwidth of Leaky-Wave Antennas

A novel technique to increase the pattern bandwidth of substrate-integrated waveguide leaky-wave antennas (SIW LWAs) is proposed. By coupling several SIWs, it is shown that the gain at the desired angle can be kept stable across a wide-frequency band. A systematic design methodology based on a simple transverse equivalent network is presented. Practical coupled-SIW designs with gain exceeding 10 dB and pointing at 30° in the 15-GHz band are reported to validate the theory. Simulation and experimental results demonstrate an enhancement of the half-power gain bandwidth from 2.5% (380 MHz) in the single-SIW design to 9% (1360 MHz) for an LWA composed of three coupled SIWs.
Chained wireless synchronization algorithm for UWB-TDOA positioning

The Time Difference of Arrival is a popular method for UWB-based positioning, since it allows high position update rate even for multiple users. However, it requires the network infrastructure (anchors) to be synchronized, preferably with sub-nanosecond accuracy. Herein, an approach for synchronizing multiple anchors in a wireless, line-of-sight manner is described. This method is able to deal with UWB modules equipped with inexpensive drift-prone oscillators, as such impairments are estimated and compensated. By applying the proposed approach the influence of generally variable environment (e.g. temperature) on timing and positioning performance is reduced. Moreover, the presented algorithm is suitable for straightforward chaining of the line-of sight-segments in order to allow synchronization of distant anchors that cannot be synchronized with the master anchor directly.
Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers

In Metazoans, transcription of most genes is driven through the use of multiple alternative promoters. Although the precise spatio-temporal regulation of alternative promoters is important for proper gene expression, the mechanism that mediates their differential utilization remains unclear. Here, we investigate how the two alternative promoters (P1, P2) that drive MYC expression are regulated. We find that P1 and P2 can be differentially regulated across cell-types, and that their selective usage is largely mediated by distal regulatory sequences. Moreover, we show that in the colon carcinoma cell line HCT-116, Wnt-responsive enhancers preferentially upregulate transcription from the P1 promoter using both transgenic reporter assays and in the context of the endogenous Myc locus upon Wnt induction. In addition, multiple enhancer deletions using CRISPR/Cas9 corroborate the regulatory specificity of P1. Finally, we show that preferential activation between Wnt-responsive enhancers and the P1 promoter is influenced by distinct core promoter elements present in the two MYC promoters. Taken together, our results provide new insights into how enhancers can specifically target alternative promoters and suggest that formation of these selective interactions could allow more diverse combinatorial regulation of transcription initiation.
Effect of Diagnosis on Outcomes in the Setting of Enhanced Recovery Protocols

BACKGROUND: Implementation of enhanced recovery protocols in colectomy reduces length of stay and morbidity, but it remains unknown whether benefits vary by clinical diagnosis. OBJECTIVE: Outcomes after colectomy in the setting of enhanced recovery protocols were compared for 3 diagnoses: 1) neoplasm, 2) diverticulitis, and 3) IBD. DESIGN: This was a retrospective registry-based cohort study. SETTINGS: Novel enhanced recovery variables were released in the American College of Surgeons National Surgical Quality Improvement Program in 2014. PATIENTS: Patients with enhanced recovery variable data undergoing elective colectomy (July 2014 to December 2015) for neoplasm, diverticulitis, or IBD were included. MAIN OUTCOME MEASURES: The primary outcome of interest was prolonged length of stay. Additional outcomes included surgical site infection, death/serious morbidity, reoperation, readmission, and days to achieve per os pain control, tolerance of a diet, and return of bowel function. RESULTS: We identified 4620 patients with neoplasm, 1730 patients with diverticulitis, and 593 patients with IBD. Patients undergoing colectomy for IBD were more likely to have prolonged length of stay (OR, 1.98; 95% CI, 1.46–2.69), death/serious morbidity (OR, 1.62; 95% CI, 1.13–2.32), and readmission (OR, 1.54; 95% CI, 1.15–2.08) compared with patients with neoplasm. Patients with IBD took longer than patients with neoplasm or diverticulitis to achieve per os pain control (mean, 4.2 days vs 3.4 and 3.5 days, p < 0.001) and tolerate a diet (mean, 4.1 days vs 3.7 and 3.5 days, p < 0.001). No statistically significant differences in outcomes between patients with neoplasm and diverticulitis were seen. LIMITATIONS: There may be heterogeneity among implemented enhanced recovery protocols. CONCLUSIONS: Patients undergoing colectomy for neoplasm and diverticulitis have improved outcomes in comparison with patients undergoing colectomy for IBD. Knowledge of expected outcomes for patients with different diagnoses may inform clinician and patient expectations. See Video Abstract at http://links.lww. com/DCR/A623.