Miracle-dz/UniFAR-FTUs huggingface dataset:
Leg power and hopping stiffness: relationship with sprint running performance.

PURPOSE Although sprint performance undoubtedly involves muscle power, the stiffness of the leg also determines sprint performance while running at maximal velocity. Results that include both of these characteristics have not been directly obtained in previous studies on human runners. We have therefore studied the link between leg power, leg stiffness, and sprint performance. METHODS The acceleration and maximal running velocity developed by 11 subjects (age 16 +/- 1) during a 40-m sprint were measured by radar. Their leg muscle volumes were estimated anthropometrically. Leg power was measured by an ergometric treadmill test and by a hopping test. Each subject executed a maximal sprint acceleration on the treadmill equipped with force and speed transducers, from which forward power was calculated. A hopping jump test was executed at 2 Hz on a force platform. Leg stiffness was calculated using the flight and contact times of the hopping test. RESULTS The treadmill forward leg power was correlated with both the initial acceleration (r = 0.80, P < 0.01) and the maximal running velocity (r = 0.73, P < 0.05) during track sprinting. The leg stiffness calculated from hopping was significantly correlated with the maximal velocity but not with acceleration. CONCLUSION Although muscle power is needed for acceleration and maintaining a maximal velocity in sprint performance, high leg stiffness may be needed for high running speed. The ability to produce a stiff rebound during the maximal running velocity could be explored by measuring the stiffness of a rebound during a vertical jump.
Pulmonary Contusion: CT vs Plain Radiograms

In experimentally induced pulmonary contusions, CT (n = 27) and chest X-ray (n = 24) findings were compared with the findings at autopsy. Twenty-seven of 27 (100%) pulmonary contusions were visible by CT immediately after trauma compared with 9 of 24 (37.5%) in the chest X-ray. After 30 min follow-up, 18 of 24 (75%) lesions were seen on the plain film. Five of 24 (21%) contusions escaped detection on conventional radiographs. Computed tomography underestimated lesion size in 5 of 60 (8%) measurements, conventional radiographs in 21 of 36 (58%) measurements. Pathological examination never revealed a pulmonary contusion that was not demonstrated by CT. Therefore, pulmonary contusion seems unlikely in a trauma patient with normal pulmonary CT.
Evaluating a new strategy for prophylaxis to prevent Pneumocystis carinii pneumonia in HIV-exposed infants in Thailand

ObjectiveTo evaluate a strategy for prophylaxis against Pneumocystis carinii pneumonia (PCP) for infants in Thailand. MethodsHIV-infected women were offered trimethoprim–sulfamethoxazole for PCP prophylaxis for their children at 1–2 months of age. When the children reached 6 months of age, investigators simulated a decision to continue or stop prophylaxis on the basis of clinical criteria, and compared their decisions with results of polymerase chain reaction (PCR) testing for HIV. We calculated the proportions of children who received and completed prophylaxis, and compared the rates of pneumonia and death from pneumonia with rates from an earlier prospective cohort. ResultsOf 395 eligible infants, 383 (97%) started prophylaxis. By 6 months of age, 10 (2.6%) were lost to follow-up, three (0.8%) were non-adherent, seven (2%) had stopped because of adverse events, four (1%) had died, and 359 (94%) still received prophylaxis. At 6 months of age, 30 (70%) of 43 HIV-infected children and 16 (5%) of 316 uninfected children met the clinical criteria to continue prophylaxis. The incidence of pneumonia at 1 to 6 months of age was 22% (15/68) in the earlier cohort, and 13% (6/46) in the recent cohort [relative risk (RR) 0.6, 95% confidence interval (CI) 0.3–1.4;P = 0.22]; mortality rates were 9% and 4%, respectively (RR 0.5; 95% CI 0.1–2.3;P = 0.47). ConclusionThis PCP prophylaxis strategy appeared to be acceptable and safe, may have reduced morbidity and mortality from pneumonia, and should be considered in developing countries where early laboratory diagnosis of perinatal HIV infection is unavailable.
Learning Channel Inter-dependencies at Multiple Scales on Dense Networks for Face Recognition

We propose a new deep network structure for unconstrained face recognition. The proposed network integrates several key components together in order to characterize complex data distributions, such as in unconstrained face images. Inspired by recent progress in deep networks, we consider some important concepts, including multi-scale feature learning, dense connections of network layers, and weighting different network flows, for building our deep network structure. The developed network is evaluated in unconstrained face matching, showing the capability of learning complex data distributions caused by face images with various qualities.
Prognostic utility of circulating transforming growth factor beta 1 in breast cancer patients

Transforming growth factor betas (TGF-βs) are multifunctional cytokines with a biphasic role in breast tumorigenesis, acting as tumor suppressors at early stages while stimulating tumor progression at later stages (TGF-β switch). Among the 3 human isoforms, TGF-β1 is known to be overexpressed in several tumor types including breast tumors. TGF-β signaling and “crosstalk” in the tumor microenvironment presents a unique challenge and an opportunity to develop novel therapies. We assessed circulating TGF-β1 levels by ELISA in blood samples from 117 previously untreated breast cancer patients in this prospective study to explore the TGF-β switch at the forefront. The levels were correlated with clinicopathological prognosticators like age, menopausal status, nodal status, histological type, histological grade, necrosis, stromal involvement, and survival. Higher mean preoperative serum TGF-β1 was observed in early-stage patients than controls (p=0.05) as revealed by receiver operating characteristic (ROC) analysis. Elevation of TGF-β1 was evident in patients with advanced-stage breast cancer compared with those having early-stage disease (p=0.0001). Prognosticators of an aggressive phenotype were associated with higher TGF-β1 levels, and higher levels thus announced the likelihood of relapse, marking the role of TGF-β1 as a tumor promoter and evidencing the existence of a TGF-β switch. Moreover, higher levels of TGF-β1 shortened the overall survival in breast cancer patients (p=0.010). The results indicate that circulating TGF-β1 may be used as a predictive and prognostic marker in breast carcinoma.
In Silico Scrutiny of Genes Revealing Phylogenetic Congruence with Clinical Prevalence or Tropism Properties of Chlamydia trachomatis Strains

Microbes possess a multiplicity of virulence factors that confer them the ability to specifically infect distinct biological niches. Contrary to what is known for other bacteria, for the obligate intracellular human pathogen Chlamydia trachomatis, the knowledge of the molecular basis underlying serovars’ tissue specificity is scarce. We examined all ~900 genes to evaluate the association between individual phylogenies and cell-appetence or ecological success of C. trachomatis strains. Only ~1% of the genes presented a tree topology showing the segregation of all three disease groups (ocular, urogenital, and lymphatic) into three well-supported clades. Approximately 28% of the genes, which include the majority of the genes encoding putative type III secretion system effectors and Inc proteins, present a phylogenetic tree where only lymphogranuloma venereum strains form a clade. Similarly, an exclusive phylogenetic segregation of the most prevalent genital serovars was observed for 61 proteins. Curiously, these serovars are phylogenetically cosegregated with the lymphogranuloma venereum serovars for ~20% of the genes. Some clade-specific pseudogenes were identified (novel findings include the conserved hypothetical protein CT037 and the predicted α-hemolysin CT473), suggesting their putative expendability for the infection of particular niches. Approximately 3.5% of the genes revealed a significant overrepresentation of nonsynonymous mutations, and the majority encode proteins that directly interact with the host. Overall, this in silico scrutiny of genes whose phylogeny is congruent with clinical prevalence or tissue specificity of C. trachomatis strains may constitute an important database of putative targets for future functional studies to evaluate their biological role in chlamydial infections.
Effect of Androgen Ablation on Prostatic Cell Differentiation in Dogs

This study was conducted to gain further insight into the role of androgen in maintaining a balanced prostate gland growth in dogs. Effects of castration on prostatic cell were assessed by comparing the expression level of high molecular weight cytokeratin (HMW), α‐actin, and vimentin in intact and castrated dogs. Mature dogs were castrated while they were under general anesthesia and were killed after 1 month. Mature prostate gland structures from intact dogs are characterized by the presence of differentiated columnar secretary epithelial cells and progenitor basal cells that are located within acini and ducts embedded in a thin fibromuscular tissue. Basal cells were distinguished from secretory epithelial cells by HMW cytokeratin immunostaining, which is expressed specifically by basal cells but not by epithelial cells. Castration‐induced secretory epithelial cell death, leave the basal cells intact to form a continuous layer lining the atrophied acini. However, the survived basal cells lost their capacity to differentiate to secretory epithelial cells. In addition, androgen ablation induced remarkable reorganization of the cellular components of the fibromuscular compartment. In intact dogs, this compartment of prostate gland is composed mainly of differentiated smooth muscles and scattered mesenchymal muscles as reflected by the high and low actin and vimentin expressions, respectively. Castration for 1 month induced a progressive shift toward mesenchymal cells, which appeared to occupy most of the fibromuscular compartment. Based on these findings, it appears that androgen acts to maintain a steady state of prostate gland by driving the differentiation of prostatic cells and by maintaining its fully differentiated state.
Collection of allogeneic peripheral blood progenitor cells by two protocols on an apheresis system

BACKGROUND: Granulocyte‐colony stimulating factor‐mobilized allogeneic peripheral blood progenitor cells (PBPCs) are replacing bone marrow in transplantation for the treatment of several hematologic malignancies. The advantages of PBPCs are offset by the donor‐associated disadvantages of granulocyte‐colony stimulating factor side effects and the risk of apheresis‐like platelet loss. STUDY DESIGN AND METHODS: For each individual, the first donation of allogeneic PBPCs by apheresis on the Spectra, using either the standard protocol Version 4.7 (45 donors, [Version 4.7]) or the AutoPBSC (60 donors, [AutoPBSC]) was compared. Between July 1995 and May 1996, all donors enrolled underwent Version 4.7 apheresis. Since May 1996, the majority of donors underwent AutoPBSC apheresis. For statistical analysis, only data from the first apheresis for each individual donor was considered for independent values. RESULTS: These results indicate a similar collection efficiency for CD34+ cells in the first apheresis of each donor (54% Version 4.7 vs. 53% AutoPBSC, p = 0.8). The apheresis time was longer with the AutoPBSC (233 min vs. 251 min, p = 0.005), whereas the loss of platelets was significantly lower (p < 0.001) with the AutoPBSC (28% vs. 19%). The mean number of CD34+ cells collected in the first apheresis component was 4.0 × 10(8) (Version 4.7) versus 3.8 × 10(8) (AutoPBSC). CONCLUSION: Both apheresis protocols collect sufficient numbers of PBSCs for allogeneic transplantation. The AutoPBSC operates in a fully automatic fashion, avoiding manual adjustment and interindividual variations. The loss of platelets is lower with AutoPBSC than with Version 4.7, but the apheresis time is slightly longer.
Investigation of numbers and motility of spermatozoa in reproductively active and socially suppressed males of two eusocial African mole-rats, the naked mole-rat (Heterocephalus glaber) and the Damaraland mole-rat (Cryptomys damarensis).

Reproductive tracts and spermatozoa from reproductively active and reproductively suppressed non-breeding males from two species of eusocial African mole-rats Cryptomys damarensis and Heterocephalus glaber were examined. In two captive colonies of Heterocephalus glaber, reproductive tracts from seven non-breeding males removed from their colonies, and housed singly for 5-6 weeks to cause reproductive activation, were compared with reproductive tracts from seven non-breeding males. The body weight of the separated, reproductively active males increased significantly (P < 0.01), and the mean testis weights relative to body weight of the reproductively active males were significantly larger (P < 0.05) than those of non-breeding males. The number of spermatozoa, in one half of the reproductive tract, was higher in active males than in non-breeding males (mean +/- SEM: 8.59 x 10(6) +/- 2.69 x 10(6) versus 1.78 x 10(6) +/- 1.43 x 10(6), respectively; P < 0.05). In addition, six of the seven reproductively active males, but only two of seven non-breeding males, had motile spermatozoa. A total of 28 wild Cryptomys damarensis from two colonies were examined in the field. The testis weights relative to body weight of breeding males (n = 7) were higher than those of non-breeding males (n = 19; P < 0.01), but the number of spermatozoa did not differ significantly between the two groups (0.13 x 10(6) +/- 0.06 x 10(6), n = 7 versus 0.29 x 10(6) +/- 0.14 x 10(6), n = 21, respectively). Breeding and non-breeding males produced similar numbers of motile spermatozoa. (ABSTRACT TRUNCATED AT 250 WORDS)
The Mini-Cog, Clock Drawing Test, and the Mini-Mental State Examination in a German Memory Clinic: specificity of separation dementia from depression

ABSTRACT Background: The aim of this study was to assess the specificities of the Mini-Cog, the Clock Drawing Test (CDT), and the Mini-Mental State Examination (MMSE) against depression and healthy controls in a German Memory Clinic. Furthermore, we analyzed the specificities of all three screening instruments in dependence of actual depression severity. Methods: Data from 142 depressed elderly, 438 dementia patients, and 64 healthy controls were retrospectively analyzed. The CDT and an extraction of the three-item recall of the MMSE were used to constitute the Mini-Cog algorithm. Depression severity was rated by either the Beck Depression Inventory (BDI) or the Geriatric Depression Scale (GDS) depending on the age of the patients. Results: The Mini-Cog achieved a specificity of 79.6% against depressed elderly and 100.0% against healthy subjects (p < 0.001). Similarly, the specificities of the CDT (83.8%) and MMSE (92.3% at a cut-off ≤24 and 90.8% at ≤25, respectively) against healthy subjects were significantly higher than the specificities against depressed patients (each p < 0.05). Concerning the depressed patients, the MMSE demonstrated significant higher specificity than the Mini-Cog and the CDT, but also showed the lowest sensitivity for the detection of dementia. Surprisingly, the depression severity had no effect on the specificity of the Mini-Cog and the CDT, only the MMSE was susceptible for the depression severity. Conclusion: Although the MMSE showed higher specificities, the weighting between the sensitivities and specificities in all tests prove again the Mini-Cog as a short, valid, and sensitive screening tool.
Diagnosing Major Depressive Disorder VI: Performance of an Objective Test as a Diagnostic Criterion

Considerable research has evaluated biological and psychological tests for various psychiatric disorders; however, few objective tests are included in DSM-IV as diagnostic criteria. It was recently suggested that existing tests are insufficiently accurate to be included as diagnostic criteria. While it is true that there are limitations in the sensitivity and/or specificity of such tests, this should not rule them out as effective diagnostic criteria. Studies examining the diagnostic efficiency of the DSM criteria sets demonstrate that the individual criteria vary in their sensitivity and specificity. In the present article, we suggest that the same standard should be applied to the evaluation of objective tests. That is, we suggest changing the perspective used to evaluate the performance of biological and psychological measures from the traditional one examining them as diagnostic tests to one in which these measures are evaluated as diagnostic criteria. To our knowledge, no previous investigators have compared the psychometric performance of an objective test to the psychometric performance of the DSM-IV symptom criteria. The recent report from the committee to develop a research agenda for the initial planning phase for DSM-V discussed the use of self-report symptom scales as possible diagnostic criteria in nonpsychiatric settings. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services project, we examined the performance of a self-report depression questionnaire as a diagnostic criterion for major depressive disorder (MDD). We compared the performance of the Diagnostic Inventory for Depression to the performance of the DSM-IV MDD symptom criteria in 1138 psychiatric outpatients. The results indicated that the diagnostic efficiency of the Diagnostic Inventory for Depression was similar to the loss of interest or pleasure criterion, and superior to all of the remaining DSM-IV MDD symptom criteria except low mood. We discuss issues related to the possible use of a self-administered depression symptom scale as a diagnostic criterion.
Benefits of Vocational Education and Training in Europe for People, Organisations and Countries.

The analysis is extended to investigate VET’s impact in organisations. It observes that organisations are communities with their own cultures. Consequently, VET’s benefits in developing skills and influencing positively wellbeing and behaviour in the workplace can interact, directly and indirectly, to improve productivity, notable through greater cooperation. However, certain circumstances need to be in place to create this effect and maximise VET’s benefits.
Adult tree swallow survival on the polychlorinated biphenyl–contaminated Hudson River, New York, USA, between 2006 and 2010

The upper Hudson River basin in east central New York, USA, is highly contaminated, primarily with polychlorinated biphenyls (PCBs). Reduced adult survival has been documented in tree swallows (Tachycineta bicolor) at a similarly PCB‐contaminated river system in western Massachusetts. The purpose of the present study was to assess whether adult survival of tree swallows was likewise affected in the Hudson River basin. Between 2006 and 2010, a total of 521 female tree swallows were banded, of which 148 were retrapped at least once. The authors used Program MARK and an information theoretic approach to test the hypothesis that PCB contamination reduced annual survival of female tree swallows. The model that best described the processes that generated the capture history data included covariate effects of year and female plumage coloration on survival but not PCB/river. Annual survival rates of brown‐plumaged females (mostly one year old) were generally lower (mean phi = 0.39) than those of blue‐plumaged females (mean phi = 0.50, one year or older). Poor early spring weather in 2007 was associated with reduced survival in both plumage‐color groups compared to later years. Models with the effects of PCB exposure on survival (all ΔAICc values >5.0) received little support. Environ. Toxicol. Chem. 2012; 31: 1788–1792. © 2012 SETAC
Molecular features of thyroid hormone‐regulated skin remodeling in Xenopus laevis during metamorphosis

Amphibian body skin provides an opportunity to investigate the molecular mechanism of thyroid hormone (TH)‐dependent organ remodeling during metamorphosis. Global gene expression changes in the TH‐dependent body skin remodeling were studied with microarray analysis. We identified 401 genes that were differentially expressed more than fourfold for 7 days after TH‐treatment. As expected, larval‐ and adult‐type keratin genes were significantly inactivated and activated, respectively. The expression changes of the Gene Ontology annotated genes demonstrated significant correlation with the morphological and physiological changes in body skin metamorphosis. The ‘transcription and proteolysis’ category genes were first upregulated 1 day after TH‐treatment. Subsequently, the ‘cell cycle’ category genes were activated at 3 days. The ‘defense response’ and ‘immune response’ category genes were the late TH‐response genes, which were downregulated and upregulated at 5 and 7 days, respectively. From these genes, adult‐type keratin‐c (xak‐c) gene was selected as a suitable gene to visually monitor the emergence of adult‐type epidermal cells during skin remodeling, because the gene is specifically expressed in adult epidermal basal cells. We generated enhanced green fluorescent protein (EGFP)‐transgenic Xenopus laevis driven by the promoter of xak‐c gene. The keratin promoter faithfully expressed the EGFP gene in adult‐type basal cells. Spatial and temporal EGFP‐fluorescence patterns of filial 1 (F1)‐offspring tadpoles visually demonstrated an event of sequential replacement of larval keratinocytes with the newly generated adult counterparts.
Altered Thalamocortical Functional Connectivity by Propofol Anesthesia in Rats

Anesthesia, a state of profound central nervous system suppression, involves a sequence of events that is still not well understood. In the present study, we examined the action of propofol (a sedative-hypnotic drug commonly used as anesthetic) on thalamocortical functional connectivity in rats by using functional connectivity magnetic resonance imaging (fcMRI) with a 3.0-tesla MR scanner. Intraperitoneal injections of propofol (80 or 160 mg/kg) were administered to Sprague-Dawley rats. Synchronized low-frequency fluctuations (LFF) of blood oxygen level-dependent (BOLD) signals were found between the thalamic and somatosensory cortices (S1/S2) after administration of 80 mg/kg propofol. However, after application of 160 mg/kg propofol, synchronized LFF of BOLD signals disappeared. These observations indicate that thalamocortical connectivity may play an important role in propofol anesthesia. We also observed that regionally specific long-range correlations of spontaneous low-frequency physiological fluctuations in BOLD signals may be present across somatosensory networks of the brain in the absence of external stimulation. However, our experiment suggests that fcMRI can be used to investigate brain networks that exhibit correlated fluctuations.