Miracle-dz/UniFAR-FTUs huggingface dataset:
Muscle dimensions of the foot in the orangutan and the chimpanzee

The hindlimbs of two orangutans and four chimpanzees were dissected, and muscle parameters (mass, fascicle length, and physiological cross‐sectional area: PCSA) were determined to explore possible interspecies variation in muscle dimensions. Muscle mass and PCSA were divided by the total mass and total PCSA of the entire foot muscles for normalization. The results indicate that the pedal interosseous and the intrinsic pedal digital extensor muscles in the orangutans probably have higher capacity for force production due to their relatively larger PCSAs than in chimpanzees. Moreover, the medial components of the intrinsic muscles exhibited relatively larger mass and PCSA ratios in orangutans. The mass and PCSA ratios of the hallucal muscles were larger in chimpanzees. These differences in foot muscle dimensions of the two species suggest that the orangutan is more specialized for hook‐like digital gripping without involvement of the rudimentary hallux, while the chimpanzee is adapted to hallux‐assisted power gripping in arboreal locomotion.
Personality-targeted interventions delay the growth of adolescent drinking and binge drinking.

BACKGROUND Personality factors are implicated in the vulnerability to adolescent alcohol misuse. This study examined whether providing personality-targeted interventions in early adolescence can delay drinking and binge drinking in high-risk youth. METHODS A randomised control trial was carried out with 368 adolescents recruited from years 9 and 10 (median age 14) with personality risk factors for substance misuse. Participants received either a personality-targeted intervention or no intervention. Outcome data were collected on alcohol use through self-reports at 6 and 12-month post intervention and analyses were conducted on the full intent to treat sample. RESULTS Multi-group analysis of a latent growth curve model showed a group difference in the growth of alcohol use between baseline and 6-months follow-up, with the control group showing a greater increase in drinking than the intervention group for this period. Interventions were particularly effective in preventing the growth of binge drinking in those students with a sensation seeking (SS) personality. SS drinkers in the intervention group were 45% and 50% less likely to binge drink at 6 (OR = .45) and 12 months (OR = .50) respectively, than SS drinkers in the control group, p = . 001, phi = . 49, Number Needed to Treat = 2.0. CONCLUSIONS Considering the robust, inverse relationship between age of onset of alcohol use and later alcohol dependence, this intervention strategy may prove effective in preventing the onset of adult alcohol use disorders, by helping high-risk youth delay the growth of their drinking to a later developmental stage.
Prevalence of At-Risk Drinking among a National Sample of Medical Students

As limited research exists on medical students’ substance use patterns, including over-consumption of alcohol, the objective of this study was to determine prevalence and correlates of at-risk drinking among a national sample of medical students, using a cross-sectional, anonymous, Web-based survey. A total of 2710 medical students from 36 U.S. medical schools (1st to 4th year) completed the survey. Included in the instruments was a 10-item scale (AUDIT) to assess at-risk drinking behaviors within the last 12 months. Over 15% of the subjects (n = 412) scored positive for at-risk drinking (≥ 8). Multivariate analysis of the data revealed the following independent predictors were statistically significant (P ≤ 0.05) for at-risk drinking: being of younger age, male, unmarried, using illicit drugs, smoking tobacco products within the last 30 days, having low perception of risk, showing impulsive behavior, being depressed, and having gambling problems. Findings from this study provides initial data for investigating further associations between risky drinking behavior, lifestyle, and psychosocial factors, as well as effectiveness of curriculum or campus-wide policy interventions to reduce over-consumption of drinking among this population.
'Right from the Start': randomized trial comparing an attachment group intervention to supportive home visiting.

BACKGROUND Infant attachment security is a protective factor for future mental health, and may be promoted by individual interventions. Given service demands, it is important to determine if a group-based intervention for parents could be used to enhance infant attachment security. METHODS In a randomized trial involving 76 mothers, an 8-session attachment group called 'Right from the Start' (RFTS) was compared to home visiting (treatment as usual). RESULTS Intention-to-treat analyses indicated no significant differences between RFTS and home visiting, with both groups showing small improvements in infant attachment security and maternal sensitivity. RFTS cost significantly less and was more cost effective than home visiting, and was not significantly different in terms of participation ratings, client satisfaction, or follow-up service requests. There was differential compliance for the two interventions, with 89% and 58% attending 4 or more sessions of home visiting and RFTS, respectively. Secondary analyses considering non-attenders as a separate (nonrandomized) group indicated a significant advantage for those who attended RFTS on pre-test/post-test maternal sensitivity change scores (d = .52) and pre-test/6-month follow-up infant attachment security changes scores (d = .55). CONCLUSIONS RFTS is as effective as home visiting in improving infant attachment security and maternal sensitivity. The effect sizes for RFTS were comparable to those of individual attachment interventions in this relatively inexpensive, community-based group intervention.
Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia

Objectives To assess the contribution of the rs3846662 polymorphism of HMGCR on serum lipid levels and statin efficacy, we measured in vivo HMGCR mRNA and lipid levels in French Canadian individuals affected by heterozygous familial hypercholesterolemia due to the deletion of more than 15 kb of the LDLR gene. Results Men and women carrying the AA genotype at rs3846662, and no APOE4 allele, had higher levels of total cholesterol (5.43 vs. 4.58 mmol/l, P<0.05) and LDL-cholesterol (5.20 vs. 4.39 mmol/l, P<0.05) at baseline. However, with regard to statin efficacy, the penetrance of the AA genotype was sex dependent. Indeed, the percentage reduction in LDL-cholesterol upon statin treatment was significantly decreased in women with the AA genotype compared with women without it (38.4 vs. 46.2%, P<0.05), whereas this was not observed in men. Although both men and women bearing the AA genotype showed a higher ratio of full-length HMGCR mRNA/total HMGCR mRNA compared with individuals without it (n=37, P<0.05), overall transcription of HMGCR was decreased and increased in men and women carrying this genotype, respectively (n=37, P<0.01 and P<0.05). Finally, in our familial hypercholesterolemia cohort, HMGCR alternative splicing explained between 22 and 55% of the variance in statin response. Conclusion rs3846662 polymorphism and the alternative splicing of HMGCR mRNA significantly impact women’s response to statin therapy.
Treatment strategies for Behçet's disease

Background: Behçet's disease (BD) is a multisytemic vasculitis characterized by oral and genital ulceration, other skin lesions, uveitis and manifestations affecting the blood vessels, CNS and gastrointestinal system. It is rare in the Western world but is frequent in the Middle and Far East. Objective: The aim of this review is to discuss treatment strategies in BD. These might vary between simple reassurance and a combination of immunosuppressives. Methods: A systematic literature search was done using the Cochrane and Medline databases in June 2008. The EULAR recommendations for the management of BD were also taken into account. Conclusion: The last two decades have witnessed considerable improvement in eye disease and musculoskeletal involvement. However, the treatment of thrombophlebitis, CNS, and gastrointestinal manifestations remains problematic.
Lasting Consequences of Bilateral Medial Temporal Lobectomy: Clinical Course and Experimental Findings in H.M.

The attention that has been devoted to the patient H.M. in terms of number of hours of evaluation and amount of journal and book space probably exceeds that devoted to any other single case. This circumstance is due to the unusual purity and severity of his amnesic syndrome, to its well-documented anatomical substrate, to the relatively static nature of his condition, and to his being a willing and cooperative subject. This article provides an overview of the history, 31-year postoperative clinical course, and neuropsychologic findings in this 58-year-old man.
Factors that influence vocabulary development in two-year-old children.

BACKGROUND This research explored the relative impact of demographic, cognitive, behavioural, and psycholinguistic factors on vocabulary development in two-year-old children. METHODS Two hundred and thirty-two children (24-30 months) were tested on expressive and receptive vocabulary, cognitive development, word learning and working memory skills. Parents completed a British adaptation (Klee & Harrison, 2001) of the MacArthur-Bates Communicative Development Inventory (CDI; Fenson et al., 1993), a demographic questionnaire and a questionnaire regarding the child's social-emotional behaviour. RESULTS Several demographic, child and processing variables were significantly correlated with CDI (vocabulary) scores, but the only significant unique predictors of CDI scores were nonword repetition (NWR; R(2) change = . 36), sex (R(2) change = . 05) and age (R(2) change = . 04). Scores were only included when a child completed the entire NWR test (77% of toddlers). CONCLUSIONS The NWR task used in this experiment maximised participation in this group of toddlers, and was a strong predictor of vocabulary ability. Longitudinal research is warranted to explore the independent and reciprocal growth in working memory and language skills in children.
Using Needs Assessment to Develop Curricula for Screening, Brief Intervention, and Referral to Treatment (SBIRT) in Academic and Community Health Settings

This article describes the use of a brief needs assessment survey in the development of alcohol and drug screening, brief intervention, and referral to treatment (SBIRT) curricula in 2 health care settings in the San Francisco Bay Area. The samples included university medical center faculty (n = 27) and nonphysician community health and social service providers in a nearby suburban county (n = 21). Informed by curriculum development theory and motivational interviewing strategies, questions regarding clinical and educational priorities, perceived importance and confidence with screening and intervention techniques, and referral resource availability were included. Medical center faculty expressed greater concern about limited appointment time (P = .003), adequacy of training (P = .025), and provider confidence (P = .038) as implementation obstacles and had lower confidence in delivering SBIRT (P = .046) and providing treatment referrals (P = .054) than community providers. The authors describe their approach to integrating needs assessment results into subsequent curriculum development. Findings highlight potential differences between physician and nonphysician training needs.
Using Standardized Patients to Evaluate Screening, Brief Intervention, and Referral to Treatment (SBIRT) Knowledge and Skill Acquisition for Internal Medicine Residents

Comprehensive clinical competency curricula for hazardous drinking and substance use disorders (SUDs) exists for medical students, residents, and practicing health care providers. Evaluations of these curricula typically focus on learner attitudes and knowledge, although changes in clinical skills are of greater interest and utility. The authors present a pre-post clinical skill evaluation of a 10-hour screening, brief intervention, and referral to treatment (SBIRT) curriculum for hazardous drinking and SUDs for primary care internal medicine residents using standardized patient examinations to better determine the impact of SBIRT training on clinical practice. Residents had large improvements in history taking, substance use screening skills, SUD assessment and diagnostic skills, and in SBIRT knowledge, including documentation, systems, and diversity issues. Residents made moderate improvements in brief intervention skills. Future SBIRT curricular evaluations would ideally include a controlled comparison with larger samples from multiple institutions.
The contribution of callous-unemotional traits and conduct problems to bullying in early adolescence.

BACKGROUND Although a lot is known about the association of conduct problems with bullying, less attention has been paid to co-occurring traits, such as callous-unemotional (CU) traits that might additionally contribute to the risk of engaging in bullying. This study investigated the contribution of CU traits to direct and indirect bullying, alongside the contributions made by conduct problems and gender. METHODS Seven hundred and four 11-13-year-olds completed self-report measures of callous-emotional traits and psychopathology, including conduct problems. Peer-report measures of direct and indirect bullying were collected from classmates. RESULTS Higher levels of CU traits were associated with higher levels of direct bullying, over and above the association between bullying and conduct problems. Conduct problems and CU traits interacted in the prediction of both direct and indirect bullying. In line with previous research, males were more likely to engage in direct and females in indirect bullying. CONCLUSIONS This study highlights the importance of viewing CU traits and conduct problems, not only as related phenomena, but also as distinct entities in mediating the underlying susceptibility of children to bully others directly. Furthermore, a combination of these traits appears to be a particularly potent risk factor for both direct and indirect bullying. Implications for intervention are discussed, in particular the concern that lack of empathy and insensitivity to punishment in those with CU traits may also make them particularly resistant to current forms of bullying intervention.
Children's responses to daily social stressors: relations with parenting, children's effortful control, and adjustment.

BACKGROUND We examined children's coping and involuntary stress responses as mediators of the relations between parenting or children's effortful control (EC) and adjustment. METHOD Two hundred and forty primarily Mexican American 7- to 12-year-old children reported on their EC, coping, involuntary stress responses, and problem behaviors. Teachers reported on children's academic competence. Parents reported on their reactions to children's negative emotions and on children's EC, problem behaviors, and academic competence. RESULTS There were significant zero-order relations between parents' affective responses to children's negative emotions, children's EC, engagement coping, disengagement coping, involuntary stress responses, and adjustment. Consistent evidence emerged that children's engagement coping and involuntary stress-responses mediate the relations between parenting or EC and adjustment. CONCLUSIONS Results highlight the utility of assessing stress responses in a multidimensional manner and have implications for intervention programs.
A cluster randomized controlled trial of child-focused psychiatric consultation and a school systems-focused intervention to reduce aggression.

BACKGROUND While school-based anti-bullying programs are widely used, there have been few controlled trials of effectiveness. This study compared the effect of manualized School Psychiatric Consultation (SPC), CAPSLE (a systems and mentalization focused whole school intervention), and treatment-as-usual (TAU) in reducing aggression and victimization among elementary school children. METHOD Participants were 1,345 third to fifth graders in nine elementary schools in a medium-sized Midwestern city who took part in a cluster-level randomized controlled trial with stratified restricted allocation, to assess efficacy after two years of active intervention and effectiveness after one year of minimal input maintenance intervention. Outcome measures included peer and self-reports of bullying, bystanding, and mentalizing behavior and classroom behavioral observations of disruptive and off-task behavior. RESULTS CAPSLE moderated the developmental trend of increasing peer-reported victimization (p < .01), aggression (p < .05), self-reported aggression (p < .05) and aggressive bystanding (p < .05), compared to TAU schools. CAPSLE also moderated a decline in empathy and an increase in the percent of children victimized compared to SPC (p < .01) and TAU conditions (p < .01). Results for self-reported victimization, helpful bystanding, and beliefs in the legitimacy of aggression did not suggest significantly different changes among the study conditions over time. CAPSLE produced a significant decrease in off-task (p < .001) and disruptive classroom behaviors (p < .01), while behavioral change was not observed in SPC and TAU schools. Superiority with respect to TAU for victimization (p < .05), aggression (p < .01), and helpful (p < .05) and aggressive bystanding (p < .01) were maintained in the follow-up year. CONCLUSIONS A teacher-implemented school-wide intervention that does not focus on disturbed children substantially reduced aggression and improved classroom behavior.
Aflatoxins in Nigerian dry‐roasted groundnuts

Samples of dry‐roasted groundnuts purchased from street hawkers, markets and retail shops in southwestern Nigeria were analysed for moisture content, fungal populations and aflatoxin contamination. The moisture content varied from 2.1 to 3.6 per cent, while the mould counts using the dilution plating method ranged from 2.9 × 102 to 6.3 × 102 colony‐forming units per gram in samples. Aflatoxin B1 was found in 64.2 per cent of samples with a mean of 25.5 ppb. Aflatoxins B2, G1 and G2 were detected in 26.4, 11.3 and 2.8 per cent of the samples with mean levels of 10.7, 7.2 and 8 ppb respectively in contaminated samples. It is concluded that the regular consumption of DRG by Nigerians might present potential health hazards.
Childhood developmental disorders: an academic and clinical convergence point for psychiatry, neurology, psychology and pediatrics.

BACKGROUND Significant advances in understanding brain development and behavior have not been accompanied by revisions of traditional academic structure. Disciplinary isolation and a lack of meaningful interdisciplinary opportunities are persistent barriers in academic medicine. To enhance clinical practice, research, and training for the next generation, academic centers will need to take bold steps that challenge traditional departmental boundaries. Such change is not only desirable but, in fact, necessary to bring about a truly innovative and more effective approach to treating disorders of the developing brain. METHODS I focus on developmental disorders as a convergence point for transcending traditional academic boundaries. First, the current taxonomy of developmental disorders is described with emphasis on how current diagnostic systems inadvertently hinder research progress. Second, I describe the clinical features of autism, a phenomenologically defined condition, and Rett and fragile X syndromes, neurogenetic diseases that are risk factors for autism. Finally, I describe how the fields of psychiatry, psychology, neurology, and pediatrics now have an unprecedented opportunity to promote an interdisciplinary approach to training, research, and clinical practice and, thus, advance a deeper understanding of developmental disorders. RESULTS Research focused on autism is increasingly demonstrating the heterogeneity of individuals diagnosed by DSM criteria. This heterogeneity hinders the ability of investigators to replicate research results as well as progress towards more effective, etiology-specific interventions. In contrast, fragile X and Rett syndromes are 'real' diseases for which advances in research are rapidly accelerating towards more disease-specific human treatment trials. CONCLUSIONS A major paradigm shift is required to improve our ability to diagnose and treat individuals with developmental disorders. This paradigm shift must take place at all levels - training, research and clinical activity. As clinicians and scientists who are currently constrained by disciplinary-specific history and training, we must move towards redefining ourselves as clinical neuroscientists with shared interests and expertise that permit a more cohesive and effective approach to improving the lives of patients.
Aversion to Injection Limits Acceptability of Extended-Release Naltrexone among Homeless, Alcohol-Dependent Patients

Background: Ending homelessness is a major priority of the Department of Veteran Affairs (VA), and alcohol use can be a barrier to stable housing. Clinical trials suggest that depot extended-release naltrexone (XR-NTX) is efficacious in reducing alcohol consumption among alcohol-dependent subjects. Methods: An open-label, randomized pilot study sought to examine the feasibility and effectiveness of XR-NTX versus oral naltrexone to improve alcohol consumption and housing stability among homeless, alcohol-dependent veterans at the Providence Veteran Affairs Medical Center. Results: Of 215 potential candidates approached over a 16-month recruitment period, only 15 agreed to consider study entry and 7 were randomized. The primary reasons given for refusal were not wanting an injection; fear of needles; and not wanting to change drinking habits. Only 1 participant in the XR-NTX group returned after the first injection. Three participants in the oral naltrexone group attended all 7 visits and had good outcomes. Conclusions: Although XR-NTX has demonstrated efficacy in reducing heavy drinking, limited acceptance of the injection might reduce its effectiveness among homeless, alcohol-dependent patients.