Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypertrophic Eccrine Glands in Eccrine Angiomatous Hamartoma Produce Gross Cystic Disease Fluid Protein 15

A 39-year-old Japanese woman presented at our clinic with a small nodule on her right small finger which she had first noticed in early childhood. Since that time the nodule had gradually enlarged with paroxysmal spontaneous pain. There were no signs or symptoms referable to the gastro-intestinal or any other system and no family history of a similar lesion. Physical examination revealed an elastic firm nodule measuring 14 ! 21 mm on the back of the right small finger. The lesion was partly bluish and excessive sweating around the area was observed (fig. 1a). No hypertrichosis was seen. All routine investigations were normal. Eccrine angiomatous hamartoma was suspected and the lesion was excised. The tumour was not well demarcated and bled freely during surgery. Histopathological examination of the excisional biopsy disclosed increased numbers of prominently hypertrophic eccrine sweat duct units and increased numbers of small thin-walled venules and capillaries in the dermis to the subcutis (fig. 1b). The hypertrophic eccrine glands (fig. 1c) were much larger than the normal control (fig. 1d). Staining for S-100 protein (fig. 1e) and CEA was positive in the dark cells of the gland. Staining for GCDFP-15 (gross cystic disease fluid protein 15) showed a diffuse and strongly positive reaction in the secretory cells, which mimics apocrine glands (fig. 1f). Myxomatous stroma was stained positively with colloidal iron. The irregular vessels were partly positive for elastica/van Gieson staining and showed apparent internal elastic laminae. However, most vessels were thinwalled venules forming a cavernous haemangioma. Eccrine angiomatous hamartoma is a rare condition first described by Lotzbeck [1] in 1859. It has also been referred as sudoriparous angioma by Domonkos and Suarez [2]. The term eccrine angiomatous hamartoma was coined by Hyman et al. [3]. We described a case with prominent hypertrophy of eccrine glands, which showed strongly positive staining for GCDFP-15. Focal s-100 protein positively and GCDFP-15 positivity have also been demonstrated in
Carrier screening of RTEL1 mutations in the Ashkenazi Jewish population

Hoyeraal–Hreidarsson syndrome (HH) is a clinically severe variant of dyskeratosis congenita (DC), characterized by cerebellar hypoplasia, microcephaly, intrauterine growth retardation, and severe immunodeficiency in addition to features of DC. Germline mutations in the RTEL1 gene have recently been identified as causative of HH. In this study, the carrier frequency for five RTEL1 mutations that occurred in individuals of Ashkenazi Jewish descent was investigated in order to advise on including them in existing clinical mutation panels for this population. Our screening showed that the carrier frequency for c.3791G>A (p.R1264H) was higher than expected, 1% in the Ashkenazi Orthodox and 0.45% in the general Ashkenazi Jewish population. Haplotype analyses suggested the presence of a common founder. We recommend that the c.3791G>A RTEL1 mutation be considered for inclusion in carrier screening panels in the Ashkenazi population.
Surgical procedures performed in the neonatal intensive care unit on critically ill neonates: feasibility and safety

BACKGROUND AND OBJECTIVE Transferring unstable, ill neonates to and from the operating room carries significant risks and can lead to morbidity. We report on our experience in performing certain procedures in critically ill neonates in the neonatal intensive care unit (NICU). We examined the feasibility and safety of such an approach. METHODS All surgical procedures performed in the the NICU between January 1999 and December 2005 were analyzed in terms of demographic data, diagnosis, preoperative stability of the patient, procedures performed, complications and outcome. Operations were performed at bedside in the NICU in critically ill, unstable neonates who needed emergency surgery, in neonates of very low birth weight (<1000 g) and in neonates on special equipment like high frequency ventilators and nitrous oxide. RESULTS Thirty-seven surgical procedures were performed including 12 laparotomies, bowel resections and stomies, 7 repairs of congenital diaphragmatic hernias, 4 ligations of patent ductus arteriosus, and various others. Birthweights ranged between 850 g and 3500 g (mean, 2000 g). Gestational age ranged between 25 to 42 weeks (mean, 33 weeks). Age at surgery was between 1 to 30 days (mean, 10 days). Preoperatively, 19 patients (51.3%) were on inotropic support and all were intubated and mechanically ventilated. There was no mortality related to surgical procedures. Postoperatively, one patient developed wound infection and disruption. CONCLUSION Performing major surgical procedures in the the NICU is both feasible and safe. It is useful in very low birth weight, critically ill neonates who have a definite risk attached to transfer to the operating room. No special area is needed in the the NICU to perform complication-free surgery, but designing an operating room within the the NICU would be ideal.
Regulation and Gene Expression of Pituitary Cells

Recent studies established a novel genomically imprinted gene located 45 kb upstream of the human GNAS1 locus. This locus encoded for the Neuroendocrine Secretory Protein with an apparent molecular weight of 55,000 (NESP55), which is transcribed exclusively from the maternal allele. We sequenced rat and human NESP55 and investigated tissue-specific splicing of its mRNA and posttranslational modifications of the protein in various tissues. Alternative mRNA splicing of NESP55 was analyzed by sequencing of cDNA clones, RT-PCR and Northern blotting. Two main splice variants, which were generated in a tissue-specific manner, were identified: The open reading frame encoding NESP55 was spliced onto exons 2–13 of Gs· in the adrenal medulla, pituitary and the brain. In addition, in the pituitary a second shorter, prominent mRNA transcript was generated by splicing of NESP55 onto exons 2, 3 and N1 of Gs·. Several of the cDNA clones isolated contained inverted repeats of 50–150 bp at their 5) or 3) termini, which might form hairpin stems and thus alter mRNA stability. The NESP55 open reading frame encoded a hydrophilic protein of 28,018 Da (human) and 29,218 Da (rat), respectively, which resembled the class of acidic, neuroendocrine secretory proteins collectively called chromogranins. NESP55 is highly conserved among mammalian species. It is posttranslationally acidified by the addition of keratan sulfate glycosaminoglycan chains and differentially processed by endopeptidases in various endocrine and neuronal tissues. Copyright © 2000 S. Karger AG, Basel
Elevated urinary excretion of aluminium and iron in multiple sclerosis

Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central nervous system of as yet unknown aetiology. A consensus of opinion has suggested that the disorder is the result of an interplay between environmental factors and susceptibility genes. We have used a battery of analytical techniques to determine if the urinary excretion of i) markers of oxidative damage; ii) iron and iii) the environmental toxin aluminium and its antagonist, silicon, are altered in relapsing remitting (RRMS) and secondary progressive MS (SPMS). Urinary concentrations of oxidative biomarkers, MDA and TBARS, were not found to be useful indicators of inflammatory disease in MS. However, urinary concentrations of another potential marker for inflammation and oxidative stress, iron, were significantly increased in SPMS (P<0.01) and insignificantly increased in RRMS (P>0.05). Urinary concentrations of aluminium were also significantly increased in RRMS (P<0.001) and SPMS (P<0.05) such that the levels of aluminium excretion in the former were similar to those observed in individuals undergoing metal chelation therapy. The excretion of silicon was lower in MS and significantly so in SPMS (P<0.05). Increased excretion of iron in urine supported a role for iron dysmetabolism in MS. Levels of urinary aluminium excretion similar to those seen in aluminium intoxication suggested that aluminium may be a hitherto unrecognized environmental factor associated with the aetiology of MS. If aluminium is involved in MS then an increased dietary intake of its natural antagonist, silicon, might be a therapeutic option.
Personality Correlates and Cyclicity in Positive and Negative Affect

The current study investigated over time variation of Positive and Negative Affect and the relation between mood level and personality characteristics. 68 male undergraduate volunteers completed the Multidimensional Personality Questionnaire and then recorded mood ratings daily over a 29-day period. Spectra time series analyses showed a distinct and significant seven-day cycle for Positive Affect and Negative Affect, with the peak in Negative Affect occurring approximately three days after that of Positive Affect. Positive Affect was significantly correlated with scores on Well-being, Social Closeness, Social Potency, and Absorption scales of the questionnaire, while Negative Affect was significantly related to scores on the Stress-Reaction, Alienation, and Aggression scales.
Two decades of SCADA exploitation: A brief history

Since the early 1960, industrial process control has been applied by electric systems. In the mid 1970's, the term SCADA emerged, describing the automated control and data acquisition. Since most industrial and automation networks were physically isolated, security was not an issue. This changed, when in the early 2000's industrial networks were opened to the public internet. The reasons were manifold. Increased interconnectivity led to more productivity, simplicity and ease of use. It decreased the configuration overhead and downtimes for system adjustments. However, it also led to an abundance of new attack vectors. In recent time, there has been a remarkable amount of attacks on industrial companies and infrastructures. In this paper, known attacks on industrial systems are analysed. This is done by investigating the exploits that are available on public sources. The different types of attacks and their points of entry are reviewed in this paper. Trends in exploitation as well as targeted attack campaigns against industrial enterprises are introduced.
Comparison of methods for determining zeta‐chain associated protein – 70 (ZAP‐70) expression in patients with B‐cell chronic lymphocytic leukemia (B‐CLL)

Zeta‐chain associated protein of 70kDa (ZAP‐70) is the most promising surrogate marker for the immunoglobulin heavy chain variable region (IgVH) mutation status in B‐cell chronic lymphocytic leukemia (B‐CLL). Crespo et al. proposed the detection of ZAP‐70 by flow cytometry. Recently several novel monoclonal antibodies appeared on market.
Mechanical properties of gelatin nanocomposite films prepared by spreading : effect of montmorillonite concentration

The use of nanoparticles as reinforcement loads may be an interesting alternative to improve the properties of gelatin films. Thus, the objectives of this study were the development of nanocomposite gelatin-based films by spreading, and the study of the effect of the nanoparticle concentration on the mechanical properties of those films. The nanocomposite-forming solutions (NFS) were prepared with 5g gelatin/100g NFS, 30g glycerol/100g gelatin and 0, 5 and 10g montmorillonite (MMT)/100g gelatin. The NFS were applied on the support using an automatic spreader (spreader height= 1.5 mm; spreader speed= 35 mm/s; base temperature= 20oC) and dehydrated at 30oC. The nanocomposite films were characterized immediately after drying (DN), and after 7 days-conditioning (CN) in 58% relative humidity at 25oC, to determine the mechanical properties by tensile tests, moisture, thickness and phase transitions by differential scanning calorimetry (DSC). The increase in MMT concentration (CMMT) increased the thickness of the films, with slightly higher effect for the CN than for the DN, and provoked decrease in the moisture of films as function of CMMT. Regarding the mechanical properties, the tensile strength of the DN and CN increased with CMMT, indicating reinforcement of the biopolymeric matrix by the nanoparticle load. Similar behavior was observed for the elastic modulus. The lower values of resistance and rigidity for the CN must be attributed to the plasticizing effect of the absorbed moisture during conditioning. Besides, the elongation at break (%) increased with the CMMT for the DN but decreased for the CN. The nanoparticles affected the phase properties, which demonstrated the plasticizing effect of the absorbed moisture, according to the DSC results. Thus, the montmorillonite contributed to reduce the susceptibility of the nanocomposite material to the environmental relative humidity, and to enhance the mechanical properties, notably resistance and rigidity.
An approach to customers daily load profile determination

Information on the customers' consumption pattern in the deregulated power systems is of primary importance. While in the regulated environment such information has been used for demand-side management and system planning in the deregulated environment also serves as a foundation for a "fair" billing system for customers without appropriate meters. In the paper an approach to daily load profile determination is proposed. For that purpose use of hierarchic clustering method is suggested which goal is to classify customers profiles into coherent groups typical load profiles (TLP). Results obtained demonstrate the ability of the suggested method to overcome problems concerning formation of TLP.
Disparities in Mental Health Care among HIV-Infected Youth

Objective: Untreated psychiatric illness is detrimental to the health and well-being of HIV-infected youth. This study examines the relationships between social and demographic variables and the rates of psychiatric treatment among HIV-infected youth. Methods: Analyses are from a cross-sectional survey of 1706 HIV-infected youth (13-26 years) in care at treatment sites or affiliates of the Adolescent Medicine Trials Network for HIV/AIDS Interventions from 2010 to 2011. Among the youth who reported recent significant mental health symptoms, comparisons on demographic variables (including race, ethnicity, language spoken, level of education, sexual orientation, and household income) were made. Results: Psychiatrically symptomatic black youth were significantly less likely than symptomatic nonblack peers to receive mental health care (37.4% versus 48.6%) and psychiatric medications (19.3% versus 26.9%). Conclusion: Care providers should be alerted to the potential disparities in mental health care treatment that exist for black youth living with HIV.
Two-photon-exchange force between charged systems: Spinless particles.

We use the methods of dispersion theory to extend to the case of two charged particles earlier studies of two-photon-exchange forces between neutral particles and between a neutral and a charged particle. The two-photon-exchange amplitude for two charged particles is infrared divergent but when we subtract the amplitude obtained by iteration of the one-photon-exchange potential, which is necessary to avoid double counting, this divergence is canceled. The difference amplitude, regarded as an analytic function of the invariant squared momentum transfer t has a discontinuity which is less singular than t/sup -1/ for small t. We are thereby led to a convergent expression for the fourth-order potential V/sup (4)/, given by the Laplace transform of this discontinuity. We give explicit gauge-invariant results for the long-range two-photon-exchange potential in the case of two spin-zero particles.
The Development and Clinical Use of Patient-Controlled Analgesia

Patient-controlled analgesia has successfully made the transition from research tool to clinical acceptability. Reliable and sophisticated patient-controlled analgesia systems are commercially available. The technique has been most used for control of postoperative pain but has been successfully used during labour, after burns and other trauma and in terminal care. Virtually every opioid has been administered by patient-controlled analgesia using almost every route of administration. It is more effective than the traditional techniques of pain control after surgery but is not automatically so. Choice of opioid and the settings chosen for demand dose and lockout interval greatly influence effectiveness. Patient-controlled analgesia requires active participation by the patient but the psychology of patient-controlled analgesia has generally been underestimated. Patient-controlled analgesia has developed empirically and many assumptions have been made; there is a need for fundamental research.
Aspiration following stroke

Among 47 patients with stroke evaluated clinically and videofluoroscopically, one-half aspirated. Patients with combined cerebral-brainstem strokes with bilateral cranial nerve signs were at greatest risk, but aspiration also occurred in the context of unilateral signs. Dysphonia was the common clinical characteristic of aspirating patients. Single chest roentgenograms were of limited value in predicting aspiration. Outcome was favorable following compensatory oral feeding programs.
The Y chromosome from autoimmune BXSB/MpJ mice induces a lupus‐like syndrome in (NZW × C57BL/6)F1 male mice, but not in C57BL/6 male mice

The Y chromosome of the BXSB mouse has been shown to be responsible for the acceleration of lupus‐like autoimmune syndrome in inbred BXSB mice and in their F1 hybrids with NZB or NZW mice. To further define the role of this as yet unidentified gene linked to the BXSB Y chromosome, designated Yaa (Y chromosome‐linked autoimmune acceleration), the Y chromosome was transferred from the BXSB strain to nonautoimmune C57BL/6 (B6) mice. The effect of the Yaa gene on the autoanti‐body formation and the development of glomerulonephritis was investigated in B6 mice and in their F1 hybrids with NZW mice. The presence of the BXSB Y chromosome was not able to induce significant autoimmune responses in B6 mice. However, (NZW × B6)F1 males bearing the BXSB Y chromosome developed a severe lupus‐like autoimmune syndrome, as documented by the production of anti‐DNA antibodies and gp70‐anti‐gp70 immune complexes and the development of lethal lupus nephritis. Both sexes of (NZW × B6)F1 hybrids without the BXSB Y chromosome were essentially normal. Our results suggest that (a) the BXSB Y chromosome by itself is not sufficient to initiate autoimmune responses in nonautoimmune B6 mice, and (b) it is able to induce autoimmune responses in mice potentially capable of developing the disease, but whose autosomal abnormality by itself is not sufficient to develop autoimmune diseases.
Feasibility Analyses of Integrated Broiler Production

The major obstacles in the development of broiler raising is the expensive price of feed and the fluctuative price of DOCs. The cheap price of imported leg quarters reduces the competitiveness of the local broilers. Therefore, an effort to increase production efficiency is needed through integration between broiler raising and corn farmers and feed producers (integrated farming). The purpose of this study is to analyze the feasibility of integrating broiler raising with corn cultivation and feed production. Besides that, a simulation was conducted to analyze the effects of DOC price changes, broiler price and production capacity. The analyses showed that integrated farming and a mere combination between broiler raising and feed factory of a 10,000 bird capacity is not financially feasible. Increasing the production to 25,000 broiler chickens will make the integrated farming financially feasible. Unintegrated broiler raising is relatively sensitive to broiler price decreases and DOC price increases compared to integrated farming.
Atmospheric turbulence profile modeling for satellite-ground laser communication

The major limitation of free-space laser communications' performances is due to atmospheric turbulence. Free-space optical channels are characterized by a set of different parameters such as the scintillation index, the Rytov variance, the Fried parameter etc. These parameters stem from the particular atmospheric turbulence model chosen. These latter produce random temperature variations of the air which in turn induce random fluctuations of its refractive index. In order to design reliable ground-to-satellite optical communications links, vertical profiles modelings of the strength of refractive turbulence, i.e. the so-called C2n structure parameter are needed. Several of these models yet exist and depend on several factors and approximations (average profile, site dependent profile, night or daytime etc.). In the framework of this thesis, a study shall identify the statu-quo of atmospheric turbulence modelling (structure parameter, inner and outer scale profiles) options. The models shall be tested and assessed with respect to realism, applicability, advantages and drawbacks by calculation of particular channel parameters. The most promising one shall be identified and further developed as possible. 1. Literature research on profile modelling of structure parameter, inner and outer scale (the Hufnagel-Valley model is the most common one. However, quite often not very suitable). The models might be given in closed form, generic or numerically given for a particular ground station site. 2. Comparison of selected models with respect to applicability, realism, accuracy, needed input parameters (overview table / technical note). 3. Calculation of LEO-Ground channel parameters for selected models and comparison and discussion of results. -Rytov variance, scintillation index, intensity correlation width, Fried parameter etc. -Consideration of weak/moderate/strong fluctuation regime 4. Selection of most useful model. This model might be further developed if possible/necessary. 5. Comparison of results with actual measurements from ground station site Oberpfaffenhofen (optional, depends on work progress). Finally the expected outcome of this thesis is the following: -Comprehensive overview on modelling option of Cn2, inner and outer scale. -Demonstration of the effect of different models on the channel parameters (Rytov variance, scintillation index, intensity correlation width, Fried parameter). -Identification of the optimal model of Cn2, inner and outer scale for the LEO-ground link.
The interaction of p 62 with RIP links the atypical PKCs to NF-κ B activation

The two members of the atypical protein kinase C (aPKC) subfamily of isozymes (ζPKC and λ / ιPKC) are involved in the control of nuclear factor κB (NFκB) through IKKβ activation. Here we show that the previously described aPKC-binding protein, p62, selectively interacts with RIP but not with TRAF2 in vitro and in vivo. p62 bridges the aPKCs to RIP, whereas the aPKCs link IKKβ to p62. In this way, a signaling cascade of interactions is established from the TNF-R1 involving TRADD/RIP/p62/aPKCs/IKKβ. These observations define a novel pathway for the activation of NF-κB involving the aPKCs and p62. Consistent with this model, the expression of a dominant-negative mutant λ / ιPKC impairs RIP-stimulated NF-κB activation. In addition, the expression of either an N-terminal aPKC-binding domain of p62, or its C-terminal RIP-binding region are sufficient to block NF-κB activation. Furthermore, transfection of an antisense construct of p62 severely abrogates NF-κB activation. Together, these results demonstrate that the interaction of p62 with RIP serves to link the atypical PKCs to the activation of NF-κB by the TNFα signaling pathway.