Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of an Employment Advisory Service by Cancer Survivors

Employment issues for cancer survivors (CS) were investigated from the perspective of Northern Ireland government general employment advisors. An e-survey was designed and developed based on the results of a scoping search of journal articles, previously validated questionnaires and relevant related surveys; discussions of draft versions of the e-survey and method with lead representatives of stakeholder organizations; and a pilot study with seven prospective respondents. The e-survey and subsequent reminder to employment advisors were distributed internally by the government employment advisory agency. The e-survey was completed by 78/156 (50%) advisors, the majority of whom (74%) received a request for advice in the last year from at least one CS. Most CS used the employment service less than 1 year (52%) or 1 year or more after treatment (32%). Fatigue was the most commonly reported barrier to returning to work (10%) and staying in work (14%), and a supportive employer was the top facilitating factor in returning to (21%) and continuing in (27%), employment. Although most advisors had a positive attitude about a CS's capacity to return to work, half were uncertain about how best to advise cancer survivors.
PERIPHERAL VASCULAR DISEASE Original Studies Angiographic Patency and Clinical Outcome After Balloon-Angioplasty for Extensive Infrapopliteal Arterial Disease

Background and objective: Restenosis-rate after balloon-angioplasty of long segment tibial arterial disease is largely unknown.We investigated the restenosis-rates angiographically in patients with critical limb ischemia (CLI) due to extensive infrapopliteal lesions. Methods: Angioplasty for infrapopliteal lesions exclusively 80 mm in length was performed using dedicated 80–120 mm long low-profile balloons. Follow-up included angiography at 3 months and clinical assessment at 3 and 15 months. Results: Angioplasty was performed in 77 infrapopliteal arteries of 62 limbs of 58 CLI patients with a Rutherford class 4 in 16 (25.8%) limbs and Rutherford class 5 in 46 limbs (74.2%). Average lesion length was 18.4 cm. Treated arteries were stenosed in 35.1% and occluded in 64.9%. After 3 months, a clinical improvement (marked reduction of ulcer-size or restpain) was seen in 47 (75.8%) limbs, 14 (22.6%) limbs were clinically unchanged and 1 (1.6%) limb showed a clinical deterioration. Angiography at 3 months showed no significant restenosis in 24 of 77 (31.2%) treated arteries, a restenosis 50% in 24 (31.2%) arteries and a reocclusion in 29 of 77 (37.6%). At 15 months death rate was 10.5%. After repeat angioplasty in case of restenosis cumulative clinical results at 15monthswereminor amputations in 8.1%, nomajor amputations resulting in a limb-salvage rate of 100% with no patient requiring bypass surgery. Conclusions: Restenosis-rate after angioplasty of extensive infrapopliteal arterial disease is high and occurs early after treatment. Despite this the clinical results are excellent, especially given the length of the arterial segments diseased. VC 2010Wiley-Liss, Inc.
The distress thermometer predicts subjective, but not objective, cognitive complaints six months after treatment initiation in cancer patients

ABSTRACT Objectives: Research has indicated that cancer-related cognitive impairments (CRCI) may be influenced by psychosocial factors such as distress, worry and fatigue. Therefore, we aimed to validate the distress thermometer (DT) as a screening tool to detect CRCI six months post-treatment-initiation in a group of general cancer patients. Methods: Patients (≥18 years, n = 125) with a histologically confirmed diagnosis of a solid cancer or hematological malignancy, scheduled for a curative treatment, were evaluated at baseline (T0) and six months post-treatment-initiation (T1) for CRCI by a neuropsychological assessment, including patient-reported outcome measures (PROMs). Assessed cognitive domains included premorbid intelligence, attention, processing speed, flexibility, verbal and visual episodic memory and verbal fluency. PROMs entailed distress (DT, cut-off ≥4, range 0–10), anxiety and depression, fatigue (FACIT-fatigue scale) and subjective cognitive complaints. Results: At T0, 60.4% of patients showed a DT score of ≥4, whereas 50% met this criterion at T1. According to the definition of the International Cognition and Cancer Task Force, 25.5% and 28.3% of patients presented with a CRCI at T0 and T1, respectively. When evaluating the DT as a screening tool for CRCI at T1, data showed an inverse relationship between the DT and CRCI. ROC-curve analysis revealed an AUC <0.5. ROC-curve analyses evaluating the DT and FACIT-fatigue scale as screening tools for subjective cognitive complaints showed an AUC ± SE of, respectively, 0.642 ± 0.067 and 0.794 ± 0.057. Conclusions: The DT at T0 cannot be used to screen for objective CRCI at T1, but both the DT and FACIT-fatigue scale at T0 showed potential as screening tools for subjective cognitive complaints at T1.
Eccrine Duct Dilation as a Marker of Cicatricial Alopecia

Background: Eccrine duct dilation (EDD) and syringoma-like sweat duct proliferation have been described as reactive changes occurring in a variety of skin conditions. However, extensive evaluation of EDD in scalp biopsies performed for alopecia has not been performed. Methods: We retrospectively examined 129 cases of cicatricial alopecia (lichen planopilaris, central centrifugal cicatricial alopecia, and discoid lupus erythematosus) and 130 cases of noncicatricial alopecias (androgenetic alopecia, telogen effluvium, and alopecia areata) for the presence of EDD. Results: Overall, EDD occurred in 4% (5/130) of noncicatricial alopecia (2/43 of androgenetic alopecia, 0/15 of telogen effluvium, 3/72 of alopecia areata) and 35% (45/129) of cicatricial alopecia (10/31 of lichen planopilaris, 17/36 central centrifugal cicatricial alopecia, and 18/62 of discoid lupus erythematosus; P < 0.0001) cases. Conclusions: EDD can infrequently occur in noncicatricial alopecias; however, the frequency of dilation is significantly increased in cicatricial alopecias. This alteration may be due to compressive or inflammatory effects inherent to the scarring process. The presence of EDD may be a useful adjunctive histopathologic feature in the diagnosis of cicatricial alopecias.
Metastasis-Associated Protein S100A4 and p53 Predict Relapse in Curatively Resected Stage III and IV (M0) Gastric Cancer

Purpose: Pathologic stage is the most important predictive factor of relapse in gastric cancer after curative resection. However, patients with the same stage often have different risks of relapse. Here, we investigated whether the expressions of molecular markers can supplement the current staging system in terms of relapse prediction. Patients and Methods: One hundred and nine stage III or IV (M0) patients who had received curative gastrectomy followed by adjuvant 5-fluorouracil and cisplatin chemotherapy were included in this study. The expressions of molecular markers including p53, p27, COX-2, HER-2, EGFR, maspin, S100A4, E-cadherin, Sp1, and p97 were analyzed by immunohistochemistry in cancer and paired normal tissues. Results: The overall relapse rate was 58.7%, and pathologic stage was a significant predictive factor of relapse (42% in stage IIIA, 48% in IIIB, 76% in IV, p = 0.005). Of the 10 markers examined, p53 and S100A4 were expressed only in tumor tissues, and S100A4 expression was significantly associated with a higher relapse rate (85% vs. 53%, p = 0.008). In multivariate analysis including tumor stage, S100A4 and p53 expression were independent predictive factors of relapse (relative risk, 6.98; 95% confidence interval [CI], 1.608-30.342, 3.49; 95% CI, 1.328-9.186, respectively). On comparing patients who expressed S100A4 or p53 with those who expressed neither, relapse rates were 58% vs. 25% in stage III (p = 0.011) and 95% vs. 59% in stage IV (M0) (p = 0.003). Conclusion: In addition to staging system, the expressions of S100A4 and p53 were significant predictive factors of relapse in gastric cancer after curative resection and adjuvant chemotherapy.
Parents as moderators of the impact of school norms and peer influences on aggression in middle school students.

This study examined parenting variables as protective factors to reduce the influence of school and peer risk factors on adolescents' aggression. Five waves of data spanning 3 years were collected from 5,581 students at 37 schools who began the 6th grade in 2001 or 2002. Class-level and perceived school norms supporting aggression, delinquent peer associations, parental support for fighting and support for nonviolence, and parental involvement were each associated with physical aggression across all waves. Each parenting variable moderated 1 or more risk factors, with the magnitude of many effects varying by gender and decreasing over time. Implications for the role parents may play in reducing the impact of school and peer risk factors for aggression are discussed.
Reduction of scatter radiation during transradial percutaneous coronary angiography: A randomized trial using a lead‐free radiation shield

Background: Occupational radiation exposure is a growing problem due to the increasing number and complexity of interventional procedures performed. Radial artery access has reduced the number of complications at the price of longer procedure duration. Radpad® scatter protection is a sterile, disposable bismuth‐barium radiation shield drape that should be able to decrease the dose of operator radiation during diagnostic and interventional procedures. Such radiation shield has never been tested in a randomized study in humans.
Outcomes following treatment of femoropopliteal in‐stent restenosis: A single center experience

Objectives: The aim of this study is to describe a single‐center experience with endovascular treatment of femoropopliteal in‐stent restenosis (ISR). Background: Femoropopliteal artery stenting is associated with a significant risk of ISR. Data are limited on the optimal treatment strategy and associated outcomes. Methods: A single institution retrospective chart review study was performed for patients who underwent endovascular treatment of femoropopliteal ISR from January 2006 to October 2008. Clinical and procedural characteristics, angiographic findings, and 12‐month primary and secondary patency rates were analyzed. Univariate analysis was performed to identify predictors of 12‐month primary patency. Results: Twenty‐two limbs were treated in 20 patients during the study period. Procedural success was achieved in 21 limbs (95.5%). Laser, balloon angioplasty, and excisional atherectomy were the primary therapy in 52.4%, 33.3%, and 14.3% of the cases, respectively. Adjunctive balloon angioplasty was performed after laser and excisional atherectomy in all cases. The mean length of ISR was 13.2 ± 11.3 cm with a significant proportion of cases (40.9%) having Type IV pattern of ISR. At 12 months, primary and combined primary‐assisted and secondary patency rates were 47.6 and 61.9%, respectively. Of the 11 limbs that did not have secondary patency, 6 had mild or no symptoms, and, therefore, repeat intervention was not performed. There was one transmetatarsal amputation during the 12‐month follow‐up period. In this study, there was no significant predictor of 12‐month primary patency. Conclusions: Treatment of ISR remains challenging with significant risk of recurrent restenosis. Further research is required to improve long‐term patency. © 2011 Wiley‐Liss, Inc.
PEDIATRIC AND CONGENITAL HEART DISEASE Original Studies Electrocardiographic Changes and Arrhythmias Following Percutaneous Atrial Septal Defect and Patent Foramen Ovale Device Closure

Objectives: To compare preand post-procedure electrocardiograms (ECGs) in a large cohort of patients after percutaneous closure of atrial septal defect (ASD) and patent foramen ovale (PFO). Background: Percutaneous device closure of ASD or PFO is commonplace. Conduction and rhythm anomalies associated with percutaneous device placement have been reported. Methods: We reviewed records for all patients who underwent percutaneous device closure of ASD or PFO at our institution from 1999 to 2008. Pre-procedure ECG and Holter studies were compared to available short term (<2 months after placement) and intermediate follow-up (>2 months) ECG or Holter. Results: Preand post-procedural ECGs were available in 610 patients (305 females, average age 50 6 18.1 years, range 1–91 years, 384 PFO, 184 ASD, 42 with multiple defects, mean device size 16 mm, range 5–38 mm). We report an incidence of 5.2% (32/610) of arrhythmias in the 4 months following device placement, including 29 patients with atrial tachyarrhythmias (ATs, 22 fibrillation, 7 flutter), 1 with junctional tachycardia, and 2 with heart block. Among other findings, the average P-wave duration was increased on intermediate follow-up as compared to early follow-up (P < 0.001). Development of new-onset 1st degree AV Block after the procedure was associated with an increased risk of ATs postprocedure (P < 0.0001). Conclusion: We report a low risk of clinically significant post-procedure arrhythmias after device placement. Clinically significant heart block occurred in only two patients (0.3%). Changes in several markers of atrial conduction were found, suggesting an effect of device closure on intra-atrial conduction.
The effects of self-esteem on job-seeking efficacy of dental hygiene students

ABSTRACTObjectives : The purpose of this study was to examine the self-esteem and job-seeking efficacy of dental hygienestudents in an attempt to provide some information on career gu idance, counseling and the development of employ-ment programs by colleges, as self-esteem seemed to be one of integral variables to affect job-seeking efficacy.Methods : The subjects in this study were the dental hygiene students i n three different colleges in South andNorth Jeolla Provinces. After a self-administered survey was co nducted, the answer sheets from 562 respondentswere analyzed by the SPSS(Statistical Package for the Social Science) WIN 12.0. Results : 1. The students investigated got a mean of 2.43 in self-estee m, which was not a high score. The sopho-mores had a better self-esteem than the freshmen and juniors, a nd the gaps among the respondents in each sub-factor of self-esteem were significant(p*<0.01, p**<0.05). 2. T he students got a mean of 3.12 in overall job-seek-ing efficacy, and there were significant differences among them in each subfactor of job-seekingefficacy(p*<0.01). 3. The freshmen were ahead of the sophomores and juniors in job-seeking efficacy, and thegaps between the former and the latter were significant(p*<0.01 ). 4. There was a significant relationship betweenthe self-perceived self-esteem and job-seeking efficacy of the students. A higher self-esteem led to a better job-seeking efficacy(p<0.01). Conclusions : The above-mentioned findings illustrated that a higher self-est eem had a more positive effect on job-seeking efficacy. Therefore the development of programs geared toward boosting the self-esteem of dental hygienestudents is required, and educational institutions should provi de quality self-esteem programs for students to planand prepare for their future, to make the right career choice, to improve their vocational adjustment, to keep pursu-ing self-development and to build the right values. (J Korean Soc Dent Hygiene 2012;12(2):327-334)Keywords: job-seeking efficacy, self-esteem색인: 구직효능감, 자아존중감
The relation of moral emotion attributions to prosocial and antisocial behavior: a meta-analysis.

This meta-analytic review of 42 studies covering 8,009 participants (ages 4-20) examines the relation of moral emotion attributions to prosocial and antisocial behavior. A significant association is found between moral emotion attributions and prosocial and antisocial behaviors (d = .26, 95% CI [.15, .38]; d = .39, 95% CI [.29, .49]). Effect sizes differ considerably across studies and this heterogeneity is attributed to moderator variables. Specifically, effect sizes for predicted antisocial behavior are larger for self-attributed moral emotions than for emotions attributed to hypothetical story characters. Effect sizes for prosocial and antisocial behaviors are associated with several other study characteristics. Results are discussed with respect to the potential significance of moral emotion attributions for the social behavior of children and adolescents.
Food Insecurity Is Associated with Health Status of Older Adults Participating in the Commodity Supplemental Food Program in a Rural Appalachian Ohio County

ABSTRACT Context. Food insecurity is associated with poorer nutritional and health status among older adults. Objectives. To assess the household food security and health status of older adults participating in the Commodity Supplemental Food Program (CSFP) and to determine the relationship of these factors. Design. A telephone survey conducted during Spring 2004 that included the 18-item Food Security Survey Module and SF-36 health status questionnaire. Setting. Athens County, Ohio, located in rural, Appalachian Ohio. Participants. Convenience sample of older adults 60 years and older [n = 91; 71.0y (8.1 SD)] receiving CSFP benefits and living in households located in Athens County, Ohio. Main Outcome Measures. Household food security status (U.S. Household Food Security Survey Module) and health status (SF-36) (physical and mental health scores in eight areas: Physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional, mental health). It was hypothesized that food insecurity would be associated with poorer health status. Results. Forty-six (50.5%), 36 (39.6%), and 9 (9.9%) subjects were from food secure, food insecure without hunger, and food insecure with hunger households, respectively. Consistent with other reports, all health scores worsened as household food security status worsened (physical functioning, p = .018; role-physical, p = .005; bodily pain, p < .001; general health, p < .001; vitality, p = .029; social functioning, p = .009; role-emotional, p = .007; mental health, p = .009), and health status was greater for those from food secure compared with food insecure households for 7 of 8 scores (physical functioning, p = .025; role-physical, p = .016; bodily pain, p = .002; general health, p < .001; social functioning, p = .014; role-emotional, p = .006; mental health, p = .003). Conclusions. This study further supports that food insecurity is related to poorer health among older adults. Further research in a larger sample of older adults participating in CSFP is warranted, as are other studies of those participating in food assistance programs.
How do children acquire early grammar and build multiword utterances? A corpus study of French children aged 2 to 4.

In the last 50 years, researchers have debated over the lexical or grammatical nature of children's early multiword utterances. Due to methodological limitations, the issue remains controversial. This corpus study explores the effect of grammatical, lexical, and pragmatic categories on mean length of utterances (MLU). A total of 312 speech samples from high-low socioeconomic status (SES) French-speaking children aged 2-4 years were annotated with a part-of-speech-tagger. Multiple regression analyses show that grammatical categories, particularly the most frequent subcategories, were the best predictors of MLU both across age and SES groups. These findings support the view that early language learning is guided by grammatical rather than by lexical words. This corpus research design can be used for future cross-linguistic and cross-pathology studies.
Single Nucleotide Polymorphisms in Human Gene icb-1 and Breast Cancer Susceptibility

In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with breast cancer susceptibility. A total of 646 women—323 breast cancer cases and just as many controls—were included. Breast cancer patients more frequently carried the homozygous genotype AA of SNP rs1467465 than did healthy women. Analysis of allele positivity revealed that AG or GG genotypes were significantly less frequent in breast cancer patients, suggesting that presence of G allele might have protective effects. Our data suggest that SNP rs1467465 of human gene icb-1 might affect breast cancer susceptibility.
Mycosis Fungoides After Solid-Organ Transplantation: Report of 2 New Cases

Long-term survival after solid-organ transplantation is increasing because of recent advances, including new immunosuppressive regimens to avoid graft rejection. However, the resultant modification of the immune system is associated with an increased risk of several cancers. The most common are skin cancers, and lymphomas are second in frequency. Nevertheless, posttransplant primary cutaneous lymphomas (PCLs) are rare, and their incidence is not well known currently. From the files of the Nephrology and Cardiology Departments of University Hospital “12 de Octubre” of Madrid, we obtained clinical data from 1612 transplanted patients and only found 2 cases of posttransplant PCLs, both were T-cell PCL. We reviewed the clinical, histopathological, and immunohistochemical characteristics; both cases were T-cell posttransplant PCLs manifested clinically as mycosis fungoides. One was a 57-year-old woman who had received a cadaveric kidney transplant, and the other was a 60-year-old man with a heart transplant. Histology and immunohistochemistry were consistent with the features of mycosis fungoides when lesions were completely developed. Up to 20% of all organ transplant recipients will suffer some form of malignancy. Unlike general population, 70% of PCLs in transplant recipients are B cell in origin and frequently show positivity for Epstein-Barr virus markers; whereas only 30% are cutaneous T-cell lymphomas. Different pathogenic hypothesis including reduced immune surveillance, chronic antigenic stimulation by transplant grafts, and the direct oncogenic effects of immunosuppressive drugs have been suggested. Although cutaneous B-cell lymphomas are more common, dermatopathologists should be aware that cutaneous T-cell lymphomas may also appear.