Miracle-dz/UniFAR-FTUs huggingface dataset:
Parental occupational pesticide exposure and nonsyndromic orofacial clefts

Abstract Nonsyndromic orofacial clefts are common birth defects. Reported risks for orofacial clefts associated with parental occupational pesticide exposure are mixed. To examine the role of parental pesticide exposure in orofacial cleft development in offspring, this study compared population-based case-control data for parental occupational exposures to insecticides, herbicides, and fungicides, alone or in combinations, during maternal (1 month before through 3 months after conception) and paternal (3 months before through 3 months after conception) critical exposure periods between orofacial cleft cases and unaffected controls. Multivariable logistic regression was used to estimate odds ratios, adjusted for relevant covariables, and 95% confidence intervals for any (yes, no) and cumulative (none, low [<median exposure level in controls], high [≥median exposure level in controls]) occupational pesticide exposures and cleft lip ± cleft palate and cleft palate. Associations for cleft lip ± cleft palate tended to be near unity for maternal or paternal occupational pesticide exposures, except for low paternal exposure to any pesticide, which produced a statistically significant inverse association with this subtype. Associations for cleft palate tended to be near unity for maternal exposures and mostly positive, but non-significant, for paternal exposures; a significant positive association was observed between paternal low exposure to insecticide + herbicide + fungicide and cleft palate. Combined parental exposure produced non-significant associations near or below unity for all orofacial cleft cases combined and cleft lip ± cleft palate and positive, but non-significant, associations for cleft palate. This study observed associations mostly near unity between maternal occupational pesticide exposure and orofacial clefts. Associations for paternal occupational pesticide exposures were mostly near or below unity for cleft lip ± cleft palate, and mostly positive for cleft palate. However, due to the limitations of this study, these subtype-specific results should be interpreted cautiously. Future research examining parental occupational pesticide exposure and orofacial clefts should attempt to improve exposure assessment and increase sample size to better facilitate risk estimation.
Cross‐group friendships and psychological well‐being: A dual pathway through social integration and empowerment

This study investigated the associations between cross-group friendships and psychological well-being among a sample of physically disabled adults. A total of 269 disabled people (Mage = 39.13, SD = 13.80; 114 females, 152 males, 3 unknown) completed questionnaires including the quality of their friendships with non-disabled people, perceived majority group's attitudes towards the minority group, collective self-esteem, collective action tendencies, own outgroup attitudes, and psychological well-being. Findings demonstrated that disabled people's cross-group friendships were directly and indirectly associated with higher levels of psychological well-being via two routes: one by promoting perceived majority attitudes which consequently led to more positive own outgroup attitudes (well-being through social integration hypothesis) and the other by leading to higher levels of collective self-esteem which enhanced collective action tendencies (well-being through empowerment hypothesis). Findings offer important insights into the study of cross-group friendships in relation to the psychological well-being of stigmatized minority group members.
Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model

ABSTRACT Osteoarthritis (OA), a degenerative joint disease characterized by progressive cartilage degeneration, is one of the leading causes of disability worldwide owing to the limited regenerative capacity of adult articular cartilage. Currently, there are no disease-modifying pharmacological or surgical therapies for OA. Fetal mammals, in contrast to adults, are capable of regenerating injured cartilage in the first two trimesters of gestation. A deeper understanding of the properties intrinsic to the response of fetal tissue to injury would allow us to modulate the way in which adult tissue responds to injury. In this study, we employed secretome proteomics to compare fetal and adult protein regulation in response to cartilage injury using an ovine cartilage defect model. The most relevant events comprised proteins associated with the immune response and inflammation, proteins specific for cartilage tissue and cartilage development, and proteins involved in cell growth and proliferation. Alarmins S100A8, S100A9 and S100A12 and coiled-coil domain containing 88A (CCDC88A), which are associated with inflammatory processes, were found to be significantly upregulated following injury in adult, but not in fetal animals. By contrast, cartilage-specific proteins like proteoglycan 4 were upregulated in response to injury only in fetal sheep postinjury. Our results demonstrate the power and relevance of the ovine fetal cartilage regeneration model presented here for the first time. The identification of previously unrecognized modulatory proteins that plausibly affect the healing process holds great promise for potential therapeutic interventions. Summary: Secretome proteomics identifies differential regulation of inflammation modulators during fetal and adult articular cartilage defect healing, offering novel strategies for therapy.
A systematic review of parent–infant interaction in infants at risk of autism

Social communicative precursors to autism spectrum disorder may influence how infants who are later diagnosed with autism spectrum disorder interact with their social partners and the responses they receive, thus bidirectionally influencing early social experience. This systematic review aimed to identify a developmental timeline for parent–infant interaction in the first 2 years of life in at-risk infants and in emergent autism spectrum disorder, and to examine any parent–infant interaction associations with later social-communicative outcomes. In total, 15 studies were identified investigating parent–infant interaction in infants at familial autism risk (i.e. with an older sibling with autism spectrum disorder). Starting from the latter part of the first year, infants at risk of autism spectrum disorder (and particularly infants with eventual autism spectrum disorder) showed parent–infant interaction differences from those with no eventual autism spectrum disorder, most notably in infant gesture use and dyadic qualities. While parental interactions did not differ by subsequent child autism spectrum disorder outcome, at-risk infants may receive different ‘compensatory’ socio-communicative inputs, and further work is needed to clarify their effects. Preliminary evidence links aspects of parent–infant interaction with later language outcomes. We discuss the potential role of parent–infant interaction in early parent-mediated intervention.
Rapid shifts in distribution and high‐latitude persistence of oceanographic habitat revealed using citizen science data from a climate change hotspot

The environmental effects of climate change are predicted to cause distribution shifts in many marine taxa, yet data are often difficult to collect. Quantifying and monitoring species’ suitable environmental habitats is a pragmatic approach for assessing changes in species distributions but is underdeveloped for quantifying climate change induced range shifts in marine systems. Specifically, habitat predictions present opportunities for quantifying spatiotemporal distribution changes while accounting for sources of natural climate variation. Here we demonstrate the utility of a marine‐based habitat model parameterized using citizen science data and remotely sensed environmental covariates for quantifying shifts in oceanographic habitat suitability over 22 years for a coastal‐pelagic fish species in a climate change hotspot. Our analyses account for the effects of natural intra‐ and interannual climate variability to reveal rapid poleward shifts in core (94.4 km/decade) and poleward edge (108.8 km/decade) oceanographic habitats. Temporal persistence of suitable oceanographic habitat at high latitudes also increased by approximately 3 months over the study period. Our approach demonstrates how marine citizen science data can be used to quantify range shifts, but necessitates shifting focus from species distributions directly, to the distribution of species’ environmental habitat preferences.
Relationships Between Eccentric and Concentric Knee Strength Capacities and Maximal Linear Deceleration Ability in Male Academy Soccer Players.

Harper, DJ, Jordan, AR, and Kiely, J. Relationships between eccentric and concentric knee strength capacities and maximal linear deceleration ability in male academy soccer players. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to investigate the relationships between maximal linear deceleration ability, and knee flexor (KF) and knee extensor (KE) strength. Fourteen male academy soccer players completed a 30-m linear sprint, a maximal linear deceleration test, and eccentric and concentric KF and KE contractions in both dominant leg (DL) and nondominant leg (NDL) at slower (60°·s) and faster (180°·s) angular velocities on an isokinetic dynamometer. Maximal linear deceleration ability was evaluated using distance-to-stop (DEC-DTS) and time-to-stop (DEC-TTS), with isokinetic peak torque representing KF and KE strength capacity. Relationships were established using Pearson's correlation coefficients (r) with magnitude-based inferences used to describe the uncertainty in the correlation. Both concentric KE and KF strength at 180°·s in the NDL had the highest correlations with deceleration ability (r = -0.76 and r = -0.78, respectively). In the DL, concentric KE and KF strength at 180°·s also had very likely large correlations with deceleration ability (r = -0.54 and -0.55, respectively). All correlations between eccentric KF strength and deceleration ability were unclear. At 180°·s, correlations between eccentric KE strength and deceleration ability were also unclear; however, at 60°·s, both DL (r = -0.63 to -0.64) and NDL (r = -0.54 to -0.55) had very likely large correlations with deceleration ability. These findings provide novel insights into the unilateral KF and KE strength capacities underpinning the ability to decelerate rapidly from high-sprint velocities.
High-resolution observations of IRAS 08544-4431: Detection of a disk orbiting a post-AGB star and of a slow disk wind.

Aims In order to study the effects of rotating disks in the post-asymptotic giant branch (post-AGB) evolution, we observe a class of binary post-AGB stars that seem to be systematically surrounded by equatorial disks and slow outflows. Although the rotating dynamics had only been well identified in three cases, the study of such structures is thought to be fundamental to the understanding of the formation of disks in various phases of the late evolution of binary stars and the ejection of planetary nebulae from evolved stars. Methods We present ALMA maps of 12CO and 13CO J=3-2 lines in the source IRAS 08544-4431, which belongs to the above mentioned class of objects. We analyzed the data by means of nebula models, which account for the expectedly composite source and can reproduce the data. From our modeling, we estimated the main nebula parameters, including the structure and dynamics and the density and temperature distributions. We discuss the uncertainties of the derived values and, in particular, their dependence on the distance. Results Our observations reveal the presence of an equatorial disk in rotation; a low-velocity outflow is also found, probably formed of gas expelled from the disk. The main characteristics of our observations and modeling of IRAS 08544-4431 are similar to those of better studied objects, confirming our interpretation. The disk rotation indicates a total central mass of about 1.8 M⊙, for a distance of 1100 pc. The disk is found to be relatively extended and has a typical diameter of ~ 4 1016 cm. The total nebular mass is ~ 2 10-2M⊙, of which ~ 90% corresponds to the disk. Assuming that the outflow is due to mass loss from the disk, we derive a disk lifetime of ~ 10000 yr. The disk angular momentum is found to be comparable to that of the binary system at present. Assuming that the disk angular momentum was transferred from the binary system, as expected, the high values of the disk angular momentum in this and other similar disks suggest that the size of the stellar orbits has significantly decreased as a consequence of disk formation.
Similarity of vocational interest profiles within families: A person‐centered approach for examining associations between circumplex profiles

Abstract Objective Our study addressed three questions concerning the similarity of vocational interests within families: (a) How similar are vocational interests of mothers and fathers? (b) How similar are vocational interests of parents and their children? (c) Is the inference about parent–child profile similarity affected by mother–father profile similarity? Method Data from N=1,624 tenth graders and their parents were used to analyze interest profile similarity by means of a pseudo‐coupling approach. Similarity was assessed on the level of observed profiles and model‐based circumplex profiles. Results Interest profiles of mother–father and parent–child dyads were more similar to each other than those of corresponding arbitrarily paired dyads. However, when the similarity between the parents’ interest profiles was accounted for, only same‐sex parent–child dyads were more similar to each other than would be expected by chance. All findings were mirrored on the level of observed profiles and model‐based circumplex profiles. Conclusions In sum, our findings support the validity of the circumplex model of vocational interests and emphasize the benefits of explicitly considering its implications when analyzing profile similarity. Moreover, we were able to show that the statistical evaluation of profile similarities must account for normative profile components.
Expression of microRNA-99a-3p in Prostate Cancer Based on Bioinformatics Data and Meta-Analysis of a Literature Review of 965 Cases

Background microRNAs (miRNAs) have a role as biomarkers in human cancer. The aim of this study was to use bioinformatics data, and review of cases identified from the literature, to investigate the role of microRNA-99a-3p (miR-99a-3p) in prostate cancer, including the identification of its target genes and signaling pathways. Material/Methods Meta-analysis from a literature review included 965 cases of prostate cancer. Bioinformatics databases interrogated for miR-99a-3p in prostate cancer included The Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO), and ArrayExpress. Twelve computational predictive algorithms were developed to integrate miR-99a-3p target gene prediction data. Bioinformatics analysis data from Gene Ontology (GO), the Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interaction (PPI) network analysis were used investigate the possible pathways and target genes for miR-99a-3p in prostate cancer. Results TCGA data showed that miR-99a was down-regulated in prostate cancer when compared with normal prostate tissue. Receiver-operating characteristic (ROC) curve area under the curve (AUC) for miR-99a-3p was 0.660 (95% CI, 0.587–0.732) or a moderate level of discriminations. Pathway analysis showed that miR-99a-3p was associated with the Wnt and vascular endothelial growth factor (VEGF) signaling pathways. The PPP3CA and HYOU1 genes, selected from the PPI network, were highly expressed in prostate cancer tissue compared with normal prostate tissue, and negatively correlated with the expression of miR-99a-3p. Conclusions In prostate cancer, miR-99a-3p expression was associated with the Wnt and VEGF signaling pathways, which might inhibit the expression of PPP3CA or HYOU1.
High-resolution computed tomography features and CT-guided microcoil localization of subcentimeter pulmonary ground-glass opacities: radiological processing prior to video-assisted thoracoscopic surgery.

Background With the rapid development of high-resolution computed tomography (HRCT), low-dose CT scanning and video-assisted thoracoscopic surgery (VATS), smaller pulmonary nodules can be detected. Subcentimeter ground-glass opacities (GGOs) are extremely difficult to diagnose and accurately locate during VATS and in surgically resected specimens. Methods From September 2013 to September 2017, 42 subcentimeter GGO lesions (≤1 cm) in 31 patients who underwent CT-guided microcoil insertion followed by VATS resection were included. All HRCT images were assessed by two experienced radiologists, and CT-guided microcoil localization procedures were performed by two experienced interventional radiologists. Results A total of 42 subcentimeter GGOs included 28 malignancies (66.7%) and 14 benign lesions (33.3%). The diameter of malignant GGOs (8.52±1.46 mm) was significantly larger than that of benign lesions (7.04±1.52 mm) (P<0.05). Seven patients had more than one GGO nodule. There were no significant differences in the location, composition, shape, margins, presence of air bronchograms, presence of the pleural indentation sign and presence of the vascular convergence sign between benign and malignant GGOs (P>0.05). All the localization procedures were performed successfully. A small pneumothorax occurred in 9 patients (21.4%), and minor hemorrhage in the lung parenchyma occurred in 8 patients (19.0%). All GGOs were easily identified during VATS and were definitively diagnosed. Conclusions Common HRCT features cannot be used as criteria for the differential diagnosis of subcentimeter benign and malignant pulmonary GGOs. CT-guided microcoil marking of these lesions prior to VATS is a feasible, safe, and effective procedure for the localization of subcentimeter pulmonary GGOs.
Genetic and phenotypic profile of 112 patients with X‐linked Charcot–Marie–Tooth disease type 1

X‐linked Charcot–Marie–Tooth disease type 1 (CMTX1), caused by mutations in gap junction protein beta 1 (GJB1), is characterized by various central nervous system symptoms and gender differences of clinical severity. The aim of this study was to identify the frequency and mutation spectrum of CMTX1 patients in Japan and to demonstrate their phenotypic diversities.
Male-on-Female Sexual Homicides in Sweden, 1990 to 2013: A Population-Based Controlled Study of Incidents, Victims, and Offenders

To date, systematic studies of sexual homicides from Europe are scarce, in which none have been conducted in Sweden. This study aims to describe male-on-female sexual homicides in Sweden and differentiate from corresponding nonsexual homicides. Unsolved and solved sexual homicide (n = 33) cases were identified in a database containing all homicides in Sweden between 1990 and 2013 (N = 2,126), and subsequently data from forensic psychiatric evaluations were collected for convicted offenders. Male-on-female sexual homicides constituted 1.6% of all homicides and the clearance rate was 82%, which is comparable with the 83% overall clearance rate but took longer time to solve. Three factors differentiated sexual from nonsexual homicides: strangulation, younger age of the victim, and the absence of eyewitnesses. In solved cases, distance from the offender’s home to the crime scene was strongly correlated with time to clearance. A majority of the offenders suffered from personality disorders, while other diagnoses were uncommon.
Is Relationship Quality Linked to Diabetes Risk and Management?: It Depends on What You Look At

Although the quality of marriage and marriage-like relationships (e.g., cohabitation) has been linked to the risk of developing diabetes and being able to effectively manage the disease once developed, it is unclear which aspects of marital quality drive these associations. Method: Using nationally representative data (Midlife in the United States, N = 800), the present study therefore examines how aspects of marriage (e.g., strain, support, marital risk, and constructive communication) are linked to diabetes outcomes and whether these links vary as a function of sociodemographic characteristics related to health (e.g., gender, race, and income). Results: Strain and marital risk were linked to an increased risk of developing diabetes and strain and poor communication were linked to an increased risk of poor diabetes management. Finally, marital support was linked to a lower risk of diabetes but only for those with lower income. Discussion: These findings inform prevention and intervention programs focusing on social support mechanisms to potentially reduce the risk of developing diabetes (e.g., reduced marital strain and marital instability) and improving diabetes control (e.g., improved communication and reduced marital strain).
Industrial Data Space Architecture Implementation Using FIWARE

We are in front of a new digital revolution that will transform the way we understand and use services and infrastructures. One of the key factors of this revolution is related to the evolution of the Internet of Things (IoT). Connected sensors will be installed in cities and homes affecting the daily life of people and providing them new ways of performing their daily activities. However, this revolution will also affect business and industry bringing the IoT to the production processes in what is called Industry 4.0. Sensor-enabled manufacturing equipment will allow real time communication, smart diagnosis and autonomous decision making. In this scope, the Industrial Data Spaces (IDS) Association has created a Reference Architecture model that aims to provide a common frame for designing and deploying Industry IoT infrastructures. In this paper, we present an implementation of such Reference Architecture based on FIWARE open source software components (Generic Enablers). We validate the proposed architecture by deploying and testing it in a real industry use case that tries to improve the maintenance and operation of milling machines. We conclude that the FIWARE-based IDS implementation fits the requirements of the IDS Reference Architecture providing open source software suitable to any Industry 4.0 environment.
Mid-term 3T MRA follow-up of intracranial aneurysms treated with the Woven EndoBridge

Introduction Angiography is the standard follow-up modality for treated aneurysms with the Woven EndoBridge (WEB), and magnetic resonance angiography (MRA) is useful for extended follow-up. We present the results of WEB-treated aneurysms with angiographic follow-up at three months and at least 18 months’ 3T MRA follow-up. Materials and methods Included were 52 patients with 53 aneurysms treated with the WEB between February 2015 and July 2016. There were 29 women and 23 men with a mean age of 60 years (median 62, range 23–76). Mean aneurysm size was 6.2 mm (median 6, range 3–16 mm). Results 3T MRA follow-up was mean 19.6 months (median 18, range 18–36 months). One patient had an aneurysm remnant at three-month angiography that was additionally coiled and with stable complete occlusion at 18 months’ 3T MRA follow-up. At three-month follow-up angiography, 44 aneurysms were completely occluded and eight had a neck remnant. At latest 3T MRA, stable complete occlusion was present in 43 aneurysms and stable neck remnant in eight. One posterior cerebral artery (PCA) dissection aneurysm was stable at three and six months but was enlarged and reopened at 18 months, confirmed with angiography. Focal signal loss by the proximal marker of the WEB was apparent in four patients without compromising diagnostic evaluation. Conclusion WEB-treated aneurysms with adequate occlusion at three-month angiography remained stable during serial 3T MRA follow-up of 18–36 months. One PCA aneurysm reopened during the 6- to 18-month interval. Once the WEB-treated aneurysm is adequately occluded in the short term, later reopening is uncommon.