Miracle-dz/UniFAR-FTUs huggingface dataset:
In-Your-Face Politics

It was March 2003 and my motherinlaw was visiting from Berkeley. I was watching George W. Bush speak to the nation about the impending war with Iraq. As she walked into the room, she turned her head away from the television in disgust. “Aach! ” she exclaimed, “I can’t bear to have that man in my face. It makes me sick to my stomach! ” Of course, the president was not actually in her face, he was speaking to us from Washington, D.C. But as I watched, the images to a significant extent bore out her impression. For the next twenty minutes, I viewed George Bush from a far more intimate, closeup visual perspective than I had viewed my own family across the dinner table. His face often filled the entire television frame, so much so that the top of his head was cut off. To obtain the same visual perspective in person, my motherinlaw would need to be either his lover or his dentist. Given her politics, the mere thought of being that close probably did make her sick to her stomach. While I initially had considered her statement a display of political histrionics, when viewed from this perspective it seemed far more plausible that she might have such a visceral reaction. Television gives us a unique visual perspective on other human beings, one that is far more intimate than we are accustomed to having with strangers in everyday life. But I had not previously thought about the consequences this might have for how we react to politicians and politics. As a film student in college, I learned to use the closeup camera shot to create a sense of emotional intensity in films: but do we really want that kind of intimacy with our politicians? In facetoface social contexts, there are strong social norms guiding © Copyright, Princeton University Press. No part of this book may be distributed, posted, or reproduced in any form by digital or mechanical means without prior written permission of the publisher.
Honey feeding protects kidney against cisplatin nephrotoxicity through suppression of inflammation

Cisplatin is a highly effective chemotherapeutic drug used to treat a wide variety of solid tumors. However, its use was limited due its dose‐limiting toxicity to the kidney. Currently, there are no therapies available to treat or prevent cisplatin nephrotoxicity. Honey is a naturally occurring complex liquid and widely used in traditional Ayurvedic medicine to treat many illnesses. However, its effect on cisplatin nephrotoxicity is unknown. To determine the role of honey in cisplatin nephrotoxicity, animals were pretreated orally for a week and then cisplatin was administered. Honey feeding was continued for another 3 days. Our results show that animals with cisplatin‐induced kidney dysfunction, as determined by increased serum creatinine, which received honey feeding had less kidney dysfunction. Improved kidney function was associated with better preservation of kidney morphology in honey‐treated group as compared to the cisplatin alone‐treated group. Interestingly, honey feeding significantly reduced cisplatin‐induced tubular epithelial cell death, immune infiltration into the kidney as well as cytokine and chemokine expression and excretion as compared to cisplatin treated animals. Western blot analysis shows that cisplatin‐induced increase in phosphorylation of NFkB was completely suppressed with honey feeding. In conclusion, honey feeding protects the kidney against cisplatin nephrotoxicity through suppression of inflammation and NFkB activation.
Transfusion-Related Risk of Secondary Bacterial Infections in Sepsis Patients: A Retrospective Cohort Study

There is a need for insight into factors that contribute to late mortality of sepsis patients. Immunomodulatory effects have been ascribed to blood transfusion. This retrospective cohort study investigates the association between the development of nosocomial bacterial infection and transfusion of leukodepleted red blood cells (RBCs) or platelets (PLTs) in survivors of the initial phase of sepsis. Patients diagnosed with sepsis after admission to the intensive care unit of a tertiary referral hospital were included. Of 134 patients with sepsis, 67 received a blood transfusion (50%). A secondary infection developed in 19 patients (14%). A multiple logistic regression model revealed that the use of immunosuppressive medication with an odds ratio (OR) of 1.17 (95% confidence interval [CI], 1.04-1.31), but not Acute Physiology and Chronic Health Evaluation II score, malignancy, HIV infection, alcohol abuse, or diabetes mellitus, was a risk factor for nosocomial infection. In an adjusted model, the amount of transfused RBCs was associated with secondary infection with an OR of 1.18 (95% CI, 1.01-1.37). Storage time of RBCs was a relevant confounder of the effect of the amount of RBCs on infection, with an adjusted OR of 1.25 (95% CI, 1.04-1.51), P = 0.02. Also, the amount of transfused PLTs was associated with secondary infection, with an OR of 1.36 (95% CI, 1.05-1.78). In conclusion, transfusion of RBCs and PLTs is associated with the onset of secondary bacterial infection in sepsis patients. Storage time of RBCs influences this increased risk. These findings suggest that immunomodulatory effects of blood transfusion contribute to adverse outcome in the convalescent phase of sepsis.
Max–Min Energy-Efficient Power Allocation in Interference-Limited Wireless Networks

The widely studied network energy efficiency (EE)-optimal problems (NEPs) emphasize optimality of system EE without taking fairness into account. In this paper, we focus on the max-min EE-optimal problem (MEP) by means of power allocation in interference-limited wireless networks. The MEP offers fairness assurance for users in terms of EE by maximizing the EE of the worst-case user. We show that the MEP is NP-hard. Based on generalized fractional programming, we propose a general EE-based update algorithm (EEUA) to tackle the MEP. One key step in the EEUA involves a nonconvex optimization and NP-hard power allocation problem, and we solve it by devising an iterative power allocation algorithm using sequential convex programming. Simulation results exhibit fast convergence, low complexity, and insensitivity to initial values of the proposed algorithms and verify that the MEP guarantees EE fairness among users, as well as reveal the differences between the MEP and the NEP.
Instituting Market-based Principles within Social Services for People Living with Mental Illness: The Case of the Revised ODSP Employment Supports Policy

Policies are shaped by social values and assumptions, and can significantly impact the delivery of health and social services. Marginalized groups are often disadvantaged in the political realm and reliant on publicly funded services and supports. The purpose of this research is to consider how public policies are constructed and implemented for marginalized groups and to increase understanding of the consequences of policy reform. It draws on a case study of the Ontario Disability Support Program, Employment Supports (ODSP-ES) and considers the impact of the policy revision that occurred in 2006 on employment support services for people living with mental illness. A constructivist grounded theory approach guided data collection and analysis. Key policy documents were analyzed and 25 key informant interviews were conducted with individuals who were involved in: the construction and/or implementation of the policy; developing and/or delivering employment services under the policy; or advocacy work related to the policy.
Intestinal zinc transfer by everted gut sacs from rats given diets containing different amounts and types of dietary fibre

Two experiments were carried out in which rats were offered diets containing different amounts and types of dietary fibre, i.e. commercial stock diet and three semi-purified diets containing no fibre, 200 g wheat bran or 200 g pectin/kg. Dietary inclusion of fibre, and especially pectin, stimulated large bowel fermentation, as indicated by caecal hypertrophy and reduced caecal pH. After 3 weeks, mucosal:serosal zinc transfer and Zn accumulation by tissue were measured using the everted-gut-sac technique. In Expt 2, incubations were carried out in the presence and absence of 0.25 mm-ouabain to assess the importance of transfer by Na+, K+-ATPase-dependent mechanisms, and some observations on glucose transport were also made. Ouabain reduced rates of transfer of both Zn and glucose and also tissue Zn accumulation. There were no significant differences in rates of Zn transfer by everted sacs from duodenal, ileal and colonic sites, but accumulation of Zn by tissue was a more important fate than transfer across the serosal surface, and accumulation by duodenal tissue was approximately twice as great as by other tissues. Mucosal:serosal transfer of glucose by ileal tissue was much more sensitive to ouabain than was Zn transfer. Previous diet appeared to alter the capacity of the intestinal tissue to transfer Zn, with the highest rates of transfer being by colonic tissue from pectin-fed rats.
A Randomized Controlled Trial of the Value of Phenotypic Testing in Addition to Genotypic Testing for HIV Drug Resistance: Evaluation of Resistance Assays (ERA) Trial Investigators

Objectives:To assess the clinical utility of phenotypic resistance testing in addition to genotypic resistance testing among HIV-1-infected patients experiencing virologic failure and with limited therapeutic options. Design:Multicenter randomized trial. Methods:Patients were eligible if a decision had been made to switch antiretroviral therapy, the most recent HIV-1 RNA plasma viral load (VL) exceeded 2000 copies/mL, and the clinician was unable to select a potent regimen of 3 or more drugs without access to a resistance test. Subjects were randomized to genotypic resistance testing alone (G arm) or to genotypic plus phenotypic testing (G + P arm). Patients had access to resistance testing at any time during follow-up (minimum of 1 year) according to the original allocation. The primary end point was change in plasma VL from baseline at 12 months. Results:Three hundred eleven patients were recruited between February 2000 and July 2001. At baseline, mean VL and CD4 count were 4.23 log10 copies/mL and 275 cells/mm3, respectively, and subjects had previous exposure to a mean of 7.7 antiretroviral drugs. There was no appreciable difference between the study arms in the drug regimens prescribed after randomization. Mean reduction in VL load at 12 months was similar in the 2 arms (G: 1.37 log10 reduction, G + P: 1.28 log10 reduction; P = 0.77), as was the proportion of subjects with VL <50 copies/mL (G: 35%, G + P: 27%). Conclusion:The study did not demonstrate added value of phenotypic resistance testing in conjunction with genotypic resistance testing in patients with limited therapeutic options.
Electrostatic properties of cowpea chlorotic mottle virus and cucumber mosaic virus capsids

Electrostatic properties of cowpea chlorotic mottle virus (CCMV) and cucumber mosaic virus (CMV) were investigated using numerical solutions to the Poisson–Boltzmann equation. Experimentally, it has been shown that CCMV particles swell in the absence of divalent cations when the pH is raised from 5 to 7. CMV, although structurally homologous, does not undergo this transition. An analysis of the calculated electrostatic potential confirms that a strong electrostatic repulsion at the calcium‐binding sites in the CCMV capsid is most likely the driving force for the capsid swelling process during the release of calcium. The binding interaction between the encapsulated genome material (RNA) inside of the capsid and the inner capsid shell is weakened during the swelling transition. This probably aids in the RNA release process, but it is unlikely that the RNA is released through capsid openings due to unfavorable electrostatic interaction between the RNA and capsid inner shell residues at these openings. Calculations of the calcium binding energies show that Ca2+ can bind both to the native and swollen forms of the CCMV virion. Favorable binding to the swollen form suggests that Ca2+ ions can induce the capsid contraction and stabilize the native form. © 2005 Wiley Periodicals, Inc. Biopolymers 82: 106–120, 2006
DO BLACK LIVES MATTER IN AMERICAN MAINSTREAM NEWS MEDIA? TWO CASE STUDIES OF POLICE-INVOLVED SHOOTINGS OF BLACK MEN EXPLAINING A RACIST MEDIA ENVIRONMENT

OF DISSERTATION DO BLACK LIVES MATTER IN AMERICAN MAINSTREAM NEWS MEDIA? TWO CASE STUDIES OF POLICE-INVOLVED SHOOTINGS OF BLACK MEN EXPLAINING A RACIST MEDIA ENVIRONMENT This dissertation examines two cases of fatal police-involved shootings of Black men in order to expose the power structures perpetuated through racist media narratives assuming the officers’ behavior was justified and the unarmed men the officers killed somehow were complicit in their death. In reporting on police-involved shootings, mainstream media practices that privilege elites and officials as primary sources of information may produce a dominant media narrative that masks the marginalization and mistreatment of minorities at the hands of these officials and their institutions. The two cases under consideration here examine the “floating signifier” of race in media coverage of (1) the shooting death of Walter Scott at the hands of North Charleston Police Officer Michael Slager in North Charleston, SC on April 4, 2015 and (2) the off-campus shooting of Samuel Dubose at the hands of University of Cincinnati Police Officer Ray Tensing on July 19, 2015. Using critical discourse analysis, the purpose of this dissertation is to offer critical inquiry into these media narratives as a necessary tool for dismantling these hegemonic media structures. The dissertation analyzes the narratives of these cases as presented in mass media to show how, if left unchecked, allowing elites and officials (particularly when they are representative of the individuals in the case) to define the narratives of such events can lead to misrepresentation of the narrative of the events. Only when video evidence disputing the police officers’ version of events did mainstream journalists begin to question the veracity of the officers’ claims their decisions to shoot these men were justified. The analysis examines the shifting discursive positions of the police, public officials, and media representatives over time in response to new (video) evidence and argument from the #BlackLivesMatter social protest movement members. The dissertation concludes with a discussion of the implications of this media environment and its semiotic practices on those groups concerned with seeking change around issues of police violence and abuses of power. For social movements like Black Lives Matter, a sympathetic or alternative media space that gives publicity to counter narratives is necessary to challenge mainstream media hegemony.
Nativity Status and Cardiovascular Disease Mortality Among Hispanic Adults

Background Hispanic persons represent a heterogeneous and growing population of any race with origins in Mexico, the Caribbean, Central America, South America, or other Spanish‐speaking countries. Previous studies have documented variation in cardiovascular risk and outcomes among Hispanic subgroups. Few studies have investigated whether these patterns vary by nativity status among Hispanic subgroups. Methods and Results We used the National Center for Health Statistics mortality file to compare deaths of Hispanic (n=1 258 229) and non‐Hispanic white (n=18 149 774) adults (aged ≥25 years) from 2003 to 2012. We identified all deaths related to cardiovascular disease (CVD) and categorized them by subtype (all CVD, ischemic, or cerebrovascular) using the underlying cause of death (International Classification of Diseases, 10th Revision codes I00–I78, I20–I25, and I60–I69, respectively). Population estimates were calculated using linear interpolation from the 2000 and 2010 US censuses. CVD accounted for 31% of all deaths among Hispanic adults. Race/ethnicity and nativity status were recorded on death certificates by the funeral director using state guidelines. Nativity status was defined as foreign versus US born; 58% of Hispanic decedents were foreign born. Overall, Hispanic adults had lower age‐adjusted CVD mortality rates than non‐Hispanic white adults (296 versus 385 per 100 000). Foreign‐born Cubans, Mexicans, and Puerto Ricans had higher CVD mortality than their US‐born counterparts (rate ratio: 2.64 [95% confidence interval, 2.46–2.81], 1.17 [95% confidence interval, 1.15–1.21], and 1.91 [95% confidence interval, 1.83–1.99], respectively). Conclusions Mortality rates for total cardiovascular, ischemic, and cerebrovascular disease are higher among foreign‐ than US‐born Hispanic adults. These findings suggest the importance of disaggregating CVD mortality by disease subtype, Hispanic subgroup, and nativity status.
Seasonal changes in microbial community structure and activity imply winter production is linked to summer hypoxia in a large lake.

Carbon and nutrient cycles in large temperate lakes such as Lake Erie are primarily driven by phototrophic and heterotrophic microorganisms, although our understanding of these is often constrained to late spring through summer due to logistical constraints. During periods of > 90% ice cover in February of 2008, 2009, and 2010, we collected samples from an icebreaker for an examination of bacterial production as well as microbial community structure. In comparison with summer months (August 2002 and 2010), we tested hypotheses concerning seasonal changes in microbial community diversity and production. Bacterial production estimates were c. 2 orders of magnitude higher (volume normalized) in summer relative to winter. Our observations further demonstrate that the microbial community, including single-celled phototrophs, varied in composition between August and February. Sediment traps deployed and collected over a 3 year period (2008-2011) confirmed that carbon export was ongoing and not limiting winter production. The results support the notion that active primary producers in winter months export carbon to the sediments that is not consumed until the warmer seasons. The establishment of this linkage is a critical observation in efforts to understand the extent and severity of annual summertime formations of a zone of regional hypoxia in Lake Erie.
Genetic epidemiology of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a late onset, rapidly progressive and ultimately fatal neurological disorder, caused by the loss of motor neurons in the brain and spinal cord. Familial aggregation of ALS, with an age‐dependent but high penetrance, is a major risk factor for ALS. Familial ALS (FALS) is clinically and genetically heterogeneous. Three genes and linkage to four additional gene loci have been identified so far and may either predominantly lead to ALS (ALSI‐ALS6) or cause multisystem neurodegeneration with ALS as an occasional symptom (tauopathies, ALS‐dementia complex). This review presents a tentative classification of the “major” ALS genes and ALS “susceptibility” genes, that may act as susceptibility factors for neurodegeneration in interaction with other genetic or environmental risk factors. Considering that mutations in ALS genes explain approximately 10% of familial as well as sporadic ALS, and most remaining cases of the discase are thought to result form the interaction of several genes and environmental factors, ALS is a paradigm for multifactorial discases.
Lower limb angiography: a prospective study comparing carbon dioxide with iodinated contrast material in 30 patients.

OBJECTIVE We prospectively compared patients' tolerance for and the usefulness of carbon dioxide (CO2) with iodinated contrast material in the study of lower limb arteries in 30 patients. SUBJECTS AND METHODS We systematically performed digital subtraction angiography with electronic injection of CO2 (injection average, 330 ml) and digital subtraction angiography with iodinated contrast material in 30 patients (20 men and 10 women; mean age, 67.5 years) suffering from lower limb ischemia. Patients were monitored for vital signs and comfort. Four reviewers subjectively evaluated vessel visibility at five levels (pelvis, thigh, knee, calf, and ankle). We used the Student's t test to evaluate the tolerance and the global examination quality. The chi-square test was used to evaluate the stratified analysis of the observers and scores of the image quality according to the anatomic level studied. Bartlett's test of equality of variances was used to compare the variances between the readers. RESULTS CO2 was less well tolerated (p < .01) than iodine was. Fifty-three percent of patients reported CO2 was equally well tolerated (53%), 40% reported more discomfort than with iodine, and 4% reported less discomfort than with iodine. Both techniques were equivalent for imaging of the iliac arteries, but CO2 performed poorly in the arteries below the knee (p << .001). CONCLUSION CO2 angiography with electronic injection proved to be less comfortable than iodinated angiography. CO2 arteriography is equivalent to iodinated arteriography for imaging the iliac arteries but imaging performance progressively degrades in the more distal arteries of the legs.
A Double Dissociation of Implicit and Explicit Memory in Younger and Older Adults

This study examined whether age-related differences in cognition influence later memory for irrelevant, or distracting, information. In Experiments 1 and 2, older adults had greater implicit memory for irrelevant information than younger adults did. When explicit memory was assessed, however, the pattern of results reversed: Younger adults performed better than older adults on an explicit memory test for the previously irrelevant information, and older adults performed less well than they had on the implicit test. Experiment 3 investigated whether this differential pattern was attributable to an age-related decline in encoding resources, by reducing the encoding resources of younger adults with a secondary task; their performance perfectly simulated the pattern shown by the older adults in the first two experiments. Both older and younger adults may remember irrelevant information, but they remember it in different ways because of age-related changes in how information is processed at encoding and utilized at retrieval.
Two Different Cytoplasmic Tails Direct Isoforms of the Membrane Cofactor Protein (CD46) to the Basolateral Surface of Madin-Darby Canine Kidney Cells*

Membrane cofactor protein (MCP; CD46), a widely distributed regulatory protein of the complement system, was analyzed for expression in polarized epithelial cells. Both a human and a simian (Vero C1008) cell line were found to contain endogenous MCP mainly on the basolateral surface. Transfected Madin-Darby canine kidney cells stably expressing human MCP delivered this protein also predominantly to the basolateral surface. A deletion mutant lacking the cytoplasmic tail was transported in a nonpolarized fashion, indicating that the targeting signal for the basolateral transport is located in the cytoplasmic domain. A characteristic feature of MCP is the presence of various isoforms that contain either of two different cytoplasmic tails as a consequence of alternative splicing. Two isoforms differing only in the cytoplasmic tail (tail 1 or 2) were analyzed for polarized expression in Madin-Darby canine kidney cells. Surface biotinylation, as well as confocal immunofluorescence microscopy, indicated that both proteins were transported to the basolateral surface. Because no sequence similarity has been observed, the two tails contain different basolateral targeting signals. A deletion mutant lacking the only tyrosine residue in tail 1 retained the polarized expression indicating that, in contrast to most basolateral sorting signals, the transport signal of the tail 1 isoform is not dependent on tyrosine. The maintenance of a targeting motif in two distinct cytoplasmic tails suggests that the basolateral expression of MCP in polarized epithelial cells is of physiological importance.