Miracle-dz/UniFAR-FTUs huggingface dataset:
Screening for hearing loss in the elderly using distortion product otoacoustic emissions, pure tones, and a self-assessment tool.

PURPOSE To determine whether distortion product otoacoustic emissions (DPOAEs) could be used as a hearing screening tool with elderly individuals living independently, and to compare the utility of different screening protocols: (a) 3 pure-tone screening protocols consisting of 30 dB HL at 1, 2, and 3 kHz; 40 dB HL at 1, 2, and 3 kHz; or 40 dB HL at 1 and 2 kHz; (b) the Hearing Handicap Inventory for the Elderly-Screening version (HHIE-S); (c) pure tones at 40 dB HL at 1 and 2 kHz plus the HHIE-S; and (d) DPOAEs. METHOD A total of 106 elderly individuals age 65-91 years were screened using the above protocols. RESULTS Pass/fail results showed that most individuals failed at 30 dB HL, followed by DPOAEs, the 40-dB HL protocols, the HHIE-S alone, and the combined pure-tone/HHIE-S protocol. All screening results were associated except the HHIE-S and 30 dB HL and the HHIE-S and DPOAEs. A McNemar analysis revealed that the differences between the correlated pass/fail results were significant except for the HHIE-S and 40 dB at 1 and 2 kHz. CONCLUSION DPOAEs can be used to screen the elderly, with the advantage that individuals do not have to voluntarily respond to the test.
Geographic Variation on Biological Parameters of Meccus picturatus (Usinger), 1939 (Hemiptera: Reduviidae)

ABSTRACT: The biological parameters related to the life cycles of three populations of Meccus picturatus (Usinger) (Hemiptera: Reduviidae), one of the main vectors of Trypanosoma cruzi Chagas (Trypanosomatida: Trypanosomatidae), were evaluated. A cohort of each of three populations from geographically isolated localities in western Mexico was maintained under similar laboratory conditions, after which all three populations were compared to each other. In each cohort, 50.9 to 72.1% of nymphs completed the cycle. The average time from N1 to adult was approximately 175 days and different for the three studied cohorts. The number of blood meals between molts varied from one to three. The hatching rates as well as the fecundity per female per day were different among the three studied populations. Our results show that the three isolated populations are statistically different in some parameters from each other, which points to the importance of studying the biological characteristics of local populations of triatomines for estimating their capacity of transmitting T. cruzi to reservoir hosts.
Addressing qualified personnel shortages for children who are deaf or hard of hearing with an interdisciplinary service learning program.

PURPOSE To describe the student training benefits for speech-language pathology graduate students involved in an interdisciplinary, community-based intervention program at a Midwestern university for families of preschool children who were deaf or hard of hearing (DHH) and auditory-based spoken language users. METHOD The Auditory and Language Enriched Program was developed to provide graduate students with a clinically relevant service learning opportunity that also met some unique community needs of families in the community. Specifically, students learned to provide families with imaginative ways to expose their children who were DHH to language and literacy and nurture their natural curiosity and zest for learning. RESULTS Statistically significant improvement was noted between pre- and postintervention questionnaires of knowledge and skill related to intervention for this population by a single group of students. CONCLUSIONS An interdisciplinary service learning approach to intervention might provide opportunities for university graduate programs to address the immediate and long-term needs of families who have chosen a spoken language outcome for their young children who are DHH while simultaneously providing invaluable experience with low-incidence populations for their preservice graduate students.
Early hearing detection and intervention: parent experiences with the diagnostic hearing assessment.

PURPOSE The aim of this study was to investigate parent experiences with the infant diagnostic hearing evaluation process. METHOD This study used a cross-sectional survey design. Surveys were distributed via parent support organizations in December 2009 to parents of children with hearing loss. A total of 416 completed surveys were received from 43 states. RESULTS The median age of diagnosis of hearing loss has decreased over time from 11 months of age to 2 months. For babies born between 2006 and 2009, the most frequently reported challenge to obtaining a diagnostic hearing evaluation by 3 months of age was a delay in appointment availability (36%). Just >¼ (27%) of parents reported that they did not feel comfortable in knowing what they needed to do next after talking with the audiologist at the time their child was diagnosed with hearing loss. CONCLUSION Significant progress has been made over the past 2 decades in reducing the age of hearing loss identification. However, many parents in this study experienced challenges that resulted in delays that exceeded Joint Committee on Infant Hearing (2007) recommendations of diagnosis by 3 months of age. The parent-reported experiences provide valuable information about areas that need further investigation to improve the early hearing detection and intervention process for children with hearing loss.
Effects of advancing age and hearing loss on gaps-in-noise test performance.

PURPOSE The present study evaluated the effects of advancing age and sensorineural hearing loss (SNHL) on approximate temporal gap detection thresholds obtained from the Gaps-in-Noise (GIN; Musiek et al., 2005) test. METHOD Approximate thresholds from the GIN test were compared among 3 groups of participants (older adults with SNHL, older adults with essentially normal hearing, and young adults with normal hearing). Analyses of variance and regression modeling were used to determine the effect of age and audibility on GIN performance. Comparisons of thresholds obtained from the 4 test lists of the GIN were also conducted. RESULTS Approximate gap thresholds differed significantly across all groups, with the poorest thresholds found in older adults with SNHL and with the best thresholds found in young adults with normal hearing. The strongest predictor of decreases in GIN performance was increased Audibility Index score, but a significant independent effect of age was also documented. Test list influenced GIN performance only in the group of young adults with normal hearing. CONCLUSIONS The GIN test is a promising clinical measure of temporal resolution. Findings from the present study suggest that age and audibility influence GIN performance and may affect test analysis and interpretation with published normative data.
Age-dependent changes in temporal-fine-structure processing in the absence of peripheral hearing loss.

PURPOSE In this study, the author sought to investigate if and when the ability to process temporal-fine-structure (TFS) cues deteriorates with age in adults with audiometrically normal hearing sensitivity. METHOD Using a cross-sectional design, the author assessed TFS sensitivity in 102 normal-hearing adults sampled from across the entire range of adulthood (ages 18-90 years), using 2 psychophysical tests for the assessment of within- and across-ear TFS processing. RESULTS Both types of TFS sensitivity (monaural and binaural) declined gradually starting in young adulthood, with the earliest significant deficit already apparent in early midlife (i.e., between ages 40 and 49 years). TFS sensitivity was not correlated with absolute sensitivity at the test frequency. CONCLUSIONS Some suprathreshold auditory processing abilities decline throughout adulthood, even when an individual's peripheral hearing is clinically normal. These deficits are not captured by a conventional, audiometric hearing assessment but may contribute to the increasing difficulties with age to identify speech in noisy environments. From a methodological point of view, the existence of such age effects warrants the use of age-matched participant groups when comparing normal and impaired peripheral hearing.
Burkholderia susongensis sp. nov., a mineral-weathering bacterium isolated from weathered rock surface.

A novel type of mineral-weathering bacterium was isolated from the weathered surface of rock (mica schist) collected from Susong (Anhui, China). Cells of strain L226(T) were Gram-stain-negative. The strain grew optimally at 30 °C, with 1 % (w/v) NaCl and at pH 7.0 in trypticase soy broth. On the basis of 16S rRNA gene phylogeny, strain L226(T) was shown to belong to the genus Burkholderia and the closest phylogenetic relatives were Burkholderia sprentiae WSM5005(T) (98.3 %), Burkholderia acidipaludis NBRC 101816(T) (98.2 %), Burkholderia tuberum STM678(T) (97.2 %) and Burkholderia diazotrophica JPY461(T) (97.1 %). The DNA G+C content was 63.5 mol% and the respiratory quinone was Q-8. The major fatty acids were C16 : 0, C17 : 0 cyclo and C19 : 0 cyclo ω8c. The polar lipid profile of strain L226(T) consisted of a mixture of phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, unknown lipids and unidentified aminophospholipids. Based on the low level of DNA-DNA relatedness (ranging from 25.8 % to 34.4 %) to the tested type strains of species of the genus Burkholderia and unique phenotypic characteristics, it is suggested that strain L226(T) represents a novel species of the genus Burkholderia, for which the name Burkholderia susongensis sp. nov., is proposed. The type strain is L226(T) ( = CCTCC AB2014142(T) = JCM 30231(T)).
Fixed Subaortic Stenosis Revisited

Seventy-two patients aged 2–65 years (mean 20.2) with fixed subaortic stenosis (FSS) are reported. All patients underwent echocardiography and angiography prior to surgical intervention. Sixty-four (89%) had discrete subaortic stenosis (DSS) and 8 (11%) tunnel type stenosis (TSS). Patients with DSS aged 2–65 years (mean 29) while patients with TSS aged 10–34 years (mean 19) and had a distinct female preponderance (7:1). Twenty-five patients (39%) with DSS had other congenital abnormalities of which aortic stenosis associated with bicuspid aortic valve was slightly more common than ventricular septal defect (7:6). Five patients with TSS had a small aortic annulus and hypoplastic aorta. Our data and those in the literature indicate that TSS although related to DSS has certain features that may set it apart as a distinct entity. In addition DSS appears to be associated with aortic stenosis and bicuspid aortic valve as frequently as with ventricular septal defect.
Exploring genetic and environmental effects in dysphonia: a twin study.

PURPOSE To explore the existence of genetic effects as well as the interaction between potential genetic effects and a voice-demanding occupation on dysphonia. METHOD One thousand seven hundred and twenty-eight Finnish twins (555 male; 1,173 female) born between 1961 and 1989 completed a questionnaire concerning vocal symptoms and occupation. The zygosity determination resulted in 125 monozygotic and 108 dizygotic full twin pairs. A composite variable called dysphonia was formed by summing 6 vocal symptoms based on the results of a factor analysis. Twin model fitting was used to explore the contribution of genetic and environmental effects on the dysphonia variable. RESULTS Individual differences in dysphonia were explained by genetic effects (35%) and nonshared environmental effects (65%). Shared environmental effects were estimated at 0%. Also, the authors found that for the participants who worked in voice-demanding occupations, the causes of dysphonia were more environmental, whereas the etiology of the symptoms was more strongly affected by genes in the participants with less voice-demanding occupations. However, this gene-environment interaction was not statistically significant. CONCLUSION Both genetic and environmental factors have an impact on the etiology of voice problems. Environmental factors, either independently or interacting with genetic factors, seem to play the key role, especially if the person has a voice-demanding occupation.
A 6‐Step Progression Model for Teaching the Hang Power Clean

summary Many strength and conditioning professionals use variations of the Olympic-style lifts as a major part of their overall conditioning program. However, when it comes to instructing beginners on how to perform these lifts, there seems to be a high amount of disagreement among professionals. Therefore, the purpose of this article is to give the strength and conditioning practitioner one of many practical approaches to teaching hang power cleans.
Identification of HEV in symptom‐free migrants and environmental samples in Italy

Hepatitis E virus (HEV) is considered an emerging pathogen in industrialized countries. The occurrence of HEV genotypes in samples of faeces from asymptomatic migrants arriving on the coasts of South Italy and environmental samples was investigated. Analyses of sequences were used to compare human and environmental genotypes. A total of 40 stool specimens, 12 samples of untreated urban sewage, 12 samples of treated urban sewage and 12 samples of surface water were analysed. Viruses were concentrated from water samples by the tangential flow ultrafiltration technique. The presence of HEV RNA was detected by nested RT‐PCR. Viral isolates were sequenced and phylogenetically characterized. Two (5%) of the 40 faecal samples tested were found to be positive for HEV RNA (G1 and G3 genotypes). The virus was detected in 25% (3/12) of the untreated sewage samples and 25% (3/12) of the surface water samples: all isolates belonged to G3 genotype. None of the treated sewage samples were found to be HEV RNA positive. The virus was detected in the faeces of two asymptomatic subjects, suggesting a potential role for symptom‐free HEV carriers as a human reservoir. G3 HEV strains were detected in the untreated sewage, as observed in similar studies conducted in other European countries but differing from another study conducted in Italy recently. Moreover, our results show the first case of HEV isolated from fresh surface waters.
Spatial pattern characteristics of water footprint for maize production in Northeast China.

BACKGROUND Water footprint (WF) methodology is essential for quantifying total water consumption of crop production and making efficient water management policies. This study calculated the green, blue, grey and total WFs of maize production in Northeast China from 1998 to 2012 and compared the values of the provinces. This study also analyzed the spatial variation and structure characteristics of the WFs at the prefecture level. RESULTS The annual average WF of maize production was 1029 m(3) per ton, which was 51% green, 21% blue and 28% grey. The WF of maize production was highest in Liaoning Province, moderate in Heilongjiang Province and lowest in Jilin Province. The spatial differences of the WFs calculated for the 36 major maize production prefectures were significant in Northeast China. There was a moderate positive spatial autocorrelation among prefectures that had similar WFs. Local indicator of spatial autocorrelation index (LISA) analysis identified prefectures with higher WFs in the southeast region of Liaoning Province and the southwest region of Heilongjiang Province and prefectures with lower WFs in the middle of Jilin Province. CONCLUSION Spatial differences in the WF of maize production were caused mainly by variations in climate conditions, soil quality, irrigation facilities and maize yield. The spatial distribution of WFs can help provide a scientific basis for optimizing maize production distribution and then formulate strategies to reduce the WF of maize production.
Attentional modulation of word recognition by children in a dual-task paradigm.

PURPOSE This study investigated an account of limited short-term memory capacity for children's speech perception in noise using a dual-task paradigm. METHOD Sixty-four normal-hearing children (7-14 years of age) participated in this study. Dual tasks were repeating monosyllabic words presented in noise at 8 dB signal-to-noise ratio and rehearsing sets of 3 or 5 digits for subsequent serial recall. Half of the children were told to allocate their primary attention to word repetition and the other half to remembering digits. Dual-task performance was compared to single-task performance. Limitations in short-term memory demands required for the primary task were measured by dual-task decrements in nonprimary tasks. RESULTS Results revealed that (a) regardless of task priority, no dual-task decrements were found for word recognition, but significant dual-task decrements were found for digit recall; (b) most children did not show the ability to allocate attention preferentially to primary tasks; and (c) younger children (7- to 10-year-olds) demonstrated improved word recognition in the dual-task conditions relative to their single-task performance. CONCLUSIONS Seven- to 8-year-old children showed the greatest improvement in word recognition at the expense of the greatest decrement in digit recall during dual tasks. Several possibilities for improved word recognition in the dual-task conditions are discussed.
Association of vitamin D serum levels and its common genetic determinants, with severity of liver fibrosis in genotype 1 chronic hepatitis C patients

Lower 25‐hydroxyvitamin D [25(OH)D] serum levels have been associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients (G1CHC). In addition, a recent genome‐wide study identified genetic variants (rs12785878, near dehydrocholesterol reductase, DHCR7; rs10741657, near CYP2R1; and rs7041, near vitamin D‐binding protein, GC) affecting 25(OH)D serum levels in healthy populations. We aimed to assess the association between vitamin D serum levels and its genetic determinants, with the severity of liver fibrosis. Two hundred and sixty patients with biopsy‐proven G1CHC were consecutively evaluated. The 25(OH)D serum levels were measured by high‐pressure liquid chromatography. All patients were genotyped for DHCR7 rs12785878, CYP2R1 rs10741657 and GC rs7041 single nucleotide polymorphisms. DHCR7 GG genotype (P = 0.003) and the severity of fibrosis (P = 0.03) were independent factors associated with lower 25(OH)D serum levels in multiple linear regression analysis. Interestingly, 53.8% (7/13) of patients with DHCR7 GG genotype had severe liver fibrosis, compared to 27.1% (67/247) of those with DHCR7 TT/TG genotype (P = 0.03). By multivariate logistic regression analysis, severe fibrosis was independently associated with older age (OR, 1.056; 95% CI, 1.023–1.089, P = 0.001), low cholesterol (OR, 0.984; 95% CI, 0.974–0.994, P = 0.002), high triglycerides (OR, 1.008; 95% CI, 1.002–1.015, P = 0.01), low 25(OH)D (OR, 0.958; 95% CI, 0.919–0.999, P = 0.04), DHCR7 GG genotype (OR, 4.222; 95% CI, 1.106–16.120; P = 0.03), moderate–severe steatosis (OR, 2.588; 95% CI, 1.355–4.943; P = 0.004) and moderate–severe necroinflammatory activity (grading) (OR, 2.437; 95% CI, 1.307–4.763; P = 0.001). No associations were found between liver fibrosis and both CYP2R1 and GC genotypes. In patients with G1CHC, GG homozygosis for DHCR7 gene and lower 25(OH)D levels are independently associated with the severity of liver fibrosis.
Compound-specific stable carbon isotopic signature of carbohydrate pyrolysis products from C3 and C4 plants.

BACKGROUND Pyrolysis-compound specific isotopic analysis (Py-CSIA: Py-GC-(FID)-C-IRMS) is a relatively novel technique that allows on-line quantification of stable isotope proportions in chromatographically separated products released by pyrolysis. Validation of the Py-CSIA technique is compulsory for molecular traceability in basic and applied research. In this work, commercial sucrose from C4 (sugarcane) and C3 (sugarbeet) photosystem plants and admixtures were studied using analytical pyrolysis (Py-GC/MS), bulk δ(13)C IRMS and δ(13)C Py-CSIA. RESULTS Major pyrolysis compounds were furfural (F), furfural-5-hydroxymethyl (HMF) and levoglucosan (LV). Bulk and main pyrolysis compound δ(13)C (‰) values were dependent on plant origin: C3 (F, -24.65 ± 0.89; HMF, -22.07 ± 0.41‰; LV, -21.74 ± 0.17‰) and C4 (F, -14.35 ± 0.89‰; HMF, -11.22 ± 0.54‰; LV, -11.44 ± 1.26‰). Significant regressions were obtained for δ(13)C of bulk and pyrolysis compounds in C3 and C4 admixtures. Furfural (F) was found (13)C depleted with respect to bulk and HMF and LV, indicating the incorporation of the light carbon atom in position 6 of carbohydrates in the furan ring after pyrolysis. CONCLUSION This is the first detailed report on the δ(13)C signature of major pyrolytically generated carbohydrate-derived molecules. The information provided by Py-CSIA is valuable for identifying source marker compounds of use in food science/fraud detection or in environmental research.
The experience of pregnancy: does age or mode of conception matter?

Objective: The aim of this study was to explore the influence of age and mode of conception on women’s perceptions of pregnancy-specific daily stressors. Background: The age of childbearing and the proportion of women conceiving with assisted reproductive technology (ART) are increasing. There is little existing evidence about whether older age or ART conception affects women’s perceptions of pregnancy-specific daily stressors. Methods: Approximately equal numbers of nulliparous women who had conceived spontaneously and with ART in three age groups (⩽ 30, 31–36, ⩾ 37) were recruited through ART clinics and nearby hospitals in Melbourne and Sydney, Australia. In the third trimester participants were interviewed and completed questionnaires including questions relating to their socioeconomic circumstances and reproductive history, and standardised instruments of mood, health and the perception of the positive and negative aspects of pregnancy during the third trimester. Results: Participants were 564 women aged 20–51 years of whom 285 (50.5%) had conceived with ART. In univariate analyses older maternal age and ART conception was associated with a more positive experience of pregnancy. However, when controlling for physical health and sociodemographic and psychological factors only, lower scores on the measures of anxiety and not being in the paid work force in the third trimester made independent contributions to more positive perceptions of pregnancy. Conclusion: Pregnancy-specific daily stressors are not influenced by maternal age or ART conception. Not being in the paid workforce in late pregnancy and being less anxious contribute to a more positive experience of pregnancy.