Miracle-dz/UniFAR-FTUs huggingface dataset:
The Growth of Physician Services for the Elderly in the United States and Canada: 1987-1992

The authors compared the growth of expenditures, prices, and volume and intensity of physician services delivered to the elderly in the United States and Canada from 1987 to 1992 using claims-level data from U.S. Medicare and from Ontario, Quebec, and British Columbia. Services were classified into clinical categories and per capita annualized expenditure, price, and volume growth ratios were calculated for each category. The expenditure growth rate is higher in the United States than in Canada for evaluation and management services (8.8 percent versus 4.5 percent), but it is lower for procedures (2.9 percent in the United States versus 4.8 percent in Canada). For procedures, prices decreased 2.4 percent per year in the United States but increased 1 . 0 percent per year in Canada, while volume increased faster in the United States (5.4 percent versus 3.8 percent in Canada). In both countries, high volume growth rates are observed in categories containing newly emerging procedures. Although policies to control prices appear easier to implement than policies to control the volume and intensity of medical care, their success in controlling expenditures is uncertain. Nonetheless, Canada has been more successful at controlling the growth in the volume of procedures than the United States.
Enhanced diastolic filling performance with lifelong physical activity in aging mice.

PURPOSE The purpose of this study was to investigate the age-related changes in diastolic filling parameters in the aging hearts of active C57Bl/6J mice throughout the life span to indicate optimal age periods for improvements in resting diastolic parameters. METHODS Fourteen C57Bl/6J mice (seven males and seven females) were individually housed at 8 wk of age in cages with a running wheel, magnetic sensor, and digital odometer. Duration, distance, and running velocity were recorded daily. Fourteen additional mice C57Bl/6J mice (seven males and seven females) were placed in individual cages without running wheels at 8 wk of age. Pulsed-wave Doppler transmitral inflow recordings with a SONOS 5500 ultrasound and 15-6L ultrasound probe were used to image the left ventricle every 4 wk throughout the life span. RESULTS Peak E wave filling velocities were significantly greater by the start of the second quarter of the life span in the mice with access to running wheels (P < 0.0001). Peak E wave velocities improved in both groups during the first half of the life span (P < 0.0001) and declined throughout the second half of the life span (P < 0.0001). Early-to-late (E:A) filling ratio was significantly greater for the physically active mice by the start of the second quarter of the life span (P < 0.0001) and continued throughout most of the remainder of the life span (P < 0.0001). No differences were observed between the two groups of mice with peak A wave filling velocities (P > 0.05). Similar findings were observed when corrected for resting heart rate. CONCLUSIONS Lifelong physical activity resulted in greater diastolic filling parameters by the second quarter of the life span, highlighting the clinical importance of regular aerobic activity in young adulthood as a mechanism for improved left ventricular performance with aging.
First simultaneous observations of daytime MSTIDs over North America using GPS‐TEC and DEMETER satellite data

We present simultaneous observations of daytime medium‐scale traveling ionospheric disturbances (MSTIDs) over North America, using measurements of the Total Electron Content (TEC) by the US GPS network and ionospheric plasma data from the DEMETER micro‐satellite. Several events show latitudinal variations of the plasma parameters at satellite altitude corresponding to the MSTID structures revealed on 2D TEC maps. In a case study with a very well defined MSTID, quasi periodic variations of the plasma density and of the ion velocity parallel to the Earth's magnetic field are observed along the satellite orbit that match the signature of the MSTID on the TEC maps. We believe it is the first simultaneous observation of parallel plasma motion in the topside ionosphere and propagating MSTID structures in the F‐region. An initial analysis of this event is performed in the light of results from simple model of ionospheric disturbances associated with Atmospheric Gravity Waves (AGWs).
Azole Resistance of Candida glabrata in a Case of Recurrent Fungemia

ABSTRACT We describe a case of recurrent Candida glabrata fungemia that became unresponsive to fluconazole treatment. Posttreatment isolates from blood and vaginal cultures of the immunocompetent patient were azole resistant and exhibited upregulated expression of CgCDR1/CgCDR2 efflux pumps compared to the original isolates. Amphotericin B therapy eradicated the infection.
Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains

Postembedding immunogold labeling was used to examine the subcellular distribution of the inwardly rectifying K+ channel Kir4.1 in rat retinal Müller cells and to compare this with the distribution of the water channel aquaporin‐4 (AQP4). The quantitative analysis suggested that both molecules are enriched in those plasma membrane domains that face the vitreous body and blood vessels. In addition, Kir4.1, but not AQP4, was concentrated in the basal ∼300–400 nm of the Müller cell microvilli. These data indicate that AQP4 may mediate the water flux known to be associated with K+ siphoning in the retina. By its highly differentiated distribution of AQP4, the Müller cell may be able to direct the water flux to select extracellular compartments while protecting others (the subretinal space) from inappropriate volume changes. The identification of specialized membrane domains with high Kir4.1 expression provides a morphological correlate for the heterogeneous K+ conductance along the Müller cell surface. GLIA 26:47–54, 1999. © 1999 Wiley‐Liss, Inc.
The effects of feeding and housing on the behaviour of the laboratory rabbit

The effects of housing, feeding time and diet composition on the behaviour of the laboratory rabbit were examined. The animals were caged individually in single or double metal cages with perforated metal floors, metal walls, and bars in the front, or kept as a group in floor pens. The light/dark cycle was 12/12 h with light from 04:00 to 16:00 hand 30 min twilight. One experiment compared feeding equal energy levels of a high energy diet (10.1 MJ/kg) and with a low energy diet (7.0 MJ/kg) at 08:00 h. The second experiment compared feeding the high energy diet at 08:00 h and at 14:00 h. In both studies the behaviour of the rabbits was recorded between 08:00 and 14:00 h and between 16:00 and 22:00 h. Feeding the animals at 14:00 h reduced abnormal behaviour during the dark period compared to feeding at 08:00 h, whereas no difference in behaviour could be detected between feeding a high-energy and a low-energy diet at 08:00 h. Animals in floor pens generally showed less abnormal behaviour than caged animals. The results indicate that the welfare for caged rabbits can be improved by feeding the animals in the afternoon rather than in the morning.
[Prevalence of hypertension in elderly long-term care residents in Spain. The Geriatric HTA study].

BACKGROUND AND OBJECTIVE This study aimed to estimate the prevalence of hypertension in elderly long-term care residents in Spain and to describe such population in terms of comorbidity and hypertension treatment and control. PATIENTS AND METHOD A countrywide cross-sectional study was conducted in May 2003 among long-term care residents aged 65 or more. Patients in palliative care units were excluded. Hypertension was defined in patients who fulfilled at least one of the following criteria: diagnosis of hypertension on the medical record, antihypertensive medication and/or highest blood pressure values during the previous year > or = 140/90 mmHg. RESULTS Overall, 13,272 subjects - mean age (standard deviation) 82.9 (7.5) years (range: 65-106 years) - were included from 223 centres; 70.6% were women. Almost 2 thirds of patients met at least one hypertension criterion (8,242 patients, 62.1%; 95% confidence interval, 61.3-62.9%). In those patients, other frequent cardiovascular risk factors were obesity (26.3%), diabetes (25.7%) and dislipemia (23.8%). A concomitant diagnosis of dementia, peripheral vascular disease, stroke or congestive heart failure was present in 37.1%, 28.3%, 26.0% and 25.1%, respectively. The proportion of hypertensive patients receiving at least one antihypertensive drug was 69.7%. Diuretics were the most commonly used agents (46.3%), followed by angiotensine converting enzyme inhibitors (34.6%). The latest blood pressure measurement was < 140/90 mmHg in 60.4% of the hypertensive patients. CONCLUSIONS Elderly long-term care residents in Spain showed a high prevalence of hypertension and other cardiovascular risk factors, and a substantial degree of associated clinical conditions. The proportion of antihypertensive drug therapy was comparable to those reported in similar studies.
To what extent can people with communication difficulties contribute to health research?

AIM To present an approach to involving people with communication disorders in research. BACKGROUND Patient and public involvement (PPI) is promoted at all stages of research, with everyone having a right to be involved. However, the high level of communication skills often required precludes the involvement of people with communication disorders. As people from several healthcare groups have communication difficulties, it is important to establish approaches that can help to involve them. DATA SOURCE A study involving people with communication difficulties using computerised aphasia treatment. REVIEW METHODS The paper describes techniques used to help an advisory group comprising people with aphasia and their carers to collaborate. Reflections on participating in a research group were elicited through videoed interviews. A thematic analysis of the video transcripts identified issues important to the group's members. DISCUSSION The approach to patient and public involvement in research enabled collaboration with people with aphasia at all stages of research, including contributing to recruitment, refinement of protocols, new research methods and dissemination of project outcomes. Allowing time for careful preparation of group meetings, facilitation techniques and activities is crucial to achieve this level of involvement. CONCLUSION The group experienced increased confidence in communicating, stimulation and feelings of empowerment and being able to influence the future treatment of people with aphasia. IMPLICATIONS FOR PRACTICE/RESEARCH People with communication difficulties need not be excluded from PPI activities designed to inform clinical practice or health research. Inclusion of this group can be made possible by using creative methods of exchanging ideas, reducing reliance on rapid, complex spoken interaction.
The effects of written emotional disclosure and coping skills training in rheumatoid arthritis: a randomized clinical trial.

OBJECTIVE Two psychological interventions for rheumatoid arthritis (RA) are cognitive-behavioral coping skills training (CST) and written emotional disclosure (WED). These approaches have developed independently, and their combination may be more effective than either one alone. Furthermore, most studies of each intervention have methodological limitations, and each needs further testing. METHOD We randomized 264 adults with RA in a 2 × 2 factorial design to 1 of 2 writing conditions (WED vs. control writing) followed by 1 of 2 training conditions (CST vs. arthritis education control training). Patient-reported pain and functioning, blinded evaluations of disease activity and walking speed, and an inflammatory marker (C-reactive protein) were assessed at baseline and 1-, 4-, and 12-month follow-ups. RESULTS Completion of each intervention was high (>90% of patients), and attrition was low (10.2% at 12-month follow-up). Hierarchical linear modeling of treatment effects over the follow-up period, and analyses of covariance at each assessment point, revealed no interactions between writing and training; however, both interventions had main effects on outcomes, with small effect sizes. Compared with control training, CST decreased pain and psychological symptoms through 12 months. The effects of WED were mixed: Compared with control writing, WED reduced disease activity and physical disability at 1 month only, but WED had more pain than control writing on 1 of 2 measures at 4 and 12 months. CONCLUSIONS The combination of WED and CST does not improve outcomes, perhaps because each intervention has unique effects at different time points. CST improves health status in RA and is recommended for patients, whereas WED has limited benefits and needs strengthening or better targeting to appropriate patients.
Maximum-speed curve-running biomechanics of sprinters with and without unilateral leg amputations

ABSTRACT On curves, non-amputees' maximum running speed is slower on smaller radii and thought to be limited by the inside leg's mechanics. Similar speed decreases would be expected for non-amputees in both counterclockwise and clockwise directions because they have symmetric legs. However, sprinters with unilateral leg amputation have asymmetric legs, which may differentially affect curve-running performance and Paralympic competitions. To investigate this and understand the biomechanical basis of curve running, we compared maximum curve-running (radius 17.2 m) performance and stride kinematics of six non-amputee sprinters and 11 sprinters with a transtibial amputation. Subjects performed randomized, counterbalanced trials: two straight, two counterclockwise curves and two clockwise curves. Non-amputees and sprinters with an amputation all ran slower on curves compared with straight running, but with different kinematics. Non-amputees ran 1.9% slower clockwise compared with counterclockwise (P<0.05). Sprinters with an amputation ran 3.9% slower with their affected leg on the inside compared with the outside of the curve (P<0.05). Non-amputees reduced stride length and frequency in both curve directions compared with straight running. Sprinters with an amputation also reduced stride length in both curve-running directions, but reduced stride frequency only on curves with the affected leg on the inside. During curve running, non-amputees and athletes with an amputation had longer contact times with their inside compared with their outside leg, suggesting that the inside leg limits performance. For sprinters with an amputation, the prolonged contact times of the affected versus unaffected leg seem to limit maximum running speed during both straight running and running on curves with the affected leg on the inside. Highlighted Article: Sprinters with a unilateral leg amputation run slower on curves with their affected leg on the inside, compared with curves with the affected leg on the outside.
Associations of Infant Subcutaneous Fat Mass with Total and Abdominal Fat Mass at School-Age: The Generation R Study.

BACKGROUND Skinfold thickness enables the measurement of overall and regional subcutaneous fatness in infancy and may be associated with total and abdominal body fat in later childhood. We examined the associations of subcutaneous fat in infancy with total and abdominal fat at school-age. METHODS In a population-based prospective cohort study among 821 children, we calculated total subcutaneous fat (sum of biceps, triceps, suprailiacal, and subscapular skinfold thicknesses) and central-to-total subcutaneous fat ratio (sum of suprailiacal and subscapular skinfold thicknesses/total subcutaneous fat) at 1.5 and 24 months. At 6 years, we measured fat mass index (total fat/height(3) ), central-to-total fat ratio (trunk fat/total fat), and android-to-gynoid fat ratio (android fat/gynoid fat) by dual-energy X-ray absorptiometry and preperitoneal fat mass area by abdominal ultrasound. RESULTS Central-to-total subcutaneous fat ratio at 1.5 months was positively associated with fat mass index and central-to-total fat ratio at 6 years, whereas both total and central-to-total subcutaneous fat ratio at 24 months were positively associated with all childhood adiposity measures. A 1-standard-deviation scores higher total subcutaneous fat at 24 months was associated with an increased risk of childhood overweight (odds ratio 1.70, 95% confidence interval 1.36, 2.12). These associations were weaker than those for body mass index and stronger among girls than boys. CONCLUSIONS Subcutaneous fat in infancy is positively associated with total and abdominal fat at school-age. Our results also suggest that skinfold thicknesses add little value to estimate later body fat, as compared with body mass index.
Chemical and biological characterization of 4'-iodo-4'-deoxydoxorubicin.

4'-Iodo-4'-deoxydoxorubicin is a doxorubicin (DXR) analogue with greater lipophilicity and reduced basicity of the amino group. In vitro 4'-iodo-4'-deoxydoxorubicin is more cytotoxic than DXR against a panel of human and murine cell lines and is characterized by a higher and faster uptake. In vivo, the spectrum of activity of 4'-iodo-4'-deoxydoxorubicin is comparable to that of DXR, but the new compound has higher activity against murine P388 leukemia resistant to DXR and against pulmonary metastases from Lewis lung carcinoma. Moreover, the new analogue exhibits antitumor activity also after p.o. administration and shows no cardiotoxicity in experimental systems.
ATYPICAL FIBROXANTHOMA OF SKIN: AN ELECTRON MICROSCOPE STUDY

Summary The ultrastructure of two atypical fibroxanthomas of skin is described. Most of the tumour cells were elongate, and contained abundant rough endoplasmic reticulum, well developed Golgi zones, and numerous small vesicles and filaments, the latter sometimes being related to masses of electron‐dense material near the plasma‐lemma. Their nuclei often showed deep surface indentations. The appearances were similar to those found in the socalled myfibroblasts that occur in granulation tissue. Multinucleated giant cells and lipid‐laden cells in the tumours appeared to be merely modified forms of the basic cells type.
Adult Attachment and Parental Bonding: Correlations between Perceived Relationship Qualities and Self-Reported Anxiety.

Ellen W. Armbruster, NCC, is an Assistant Professor at Central Michigan University. David C. Witherington is an Associate Professor at the University of New Mexico. The authors also wish to acknowledge the contributions of David Olguin, Jay Parkes, Gene Coffield, and Jeffrey Katzman. Correspondence can be addressed to Ellen Armbruster, Education and Human Services Bldg. #353, Central Michigan University, Mt. Pleasant, MI 48859, armbr1ew@cmich.edu. Ellen W. Ambruster, David C. Witherington Adult Attachment and Parental Bonding: Correlations Between Perceived Relationship Qualities and Self-Reported Anxiety
Dietary fatty acid thresholds and cholesterolemia

Results obtained with cebus monkeys indicate that dietary myristic (14:0) and palmitic (16:0) acids exert disparate effects on cholesterol metabolism, whereas the ability of linoleic acid (18:2) to decrease total plasma cholesterol displays an upper limit or threshold. Reanalysis of published data suggests a similar situation pertains in humans. In agreement with an earlier human study, 14:0 appears to be the principal saturated fatty acid that raises plasma cholesterol whereas 18:2 lowers it. Oleic acid (18:1) appears neutral. The effect of 16:0 may vary. In normocholesterolemic subjects consuming diets containing ≤ 300 mg/day of cholesterol, 16:0 appears to be without effect on plasma cholesterol. However, in hypercholesterolemic subjects (> 225 mg/dl) and especially those consuming diets providing cholesterol intakes of e 400 mg/day, dietary 16:0 may expand the plasma cholesterol pool. —Hayes, K. C. ; Khosla, P. Dietary fatty acid thresholds and cholesterolemia. FASEB J. 6: 2600‐2607; 1992.
Image segmentation via foreground and background semantic descriptors

Abstract. In the field of image processing, it has been a challenging task to obtain a complete foreground that is not uniform in color or texture. Unlike other methods, which segment the image by only using low-level features, we present a segmentation framework, in which high-level visual features, such as semantic information, are used. First, the initial semantic labels were obtained by using the nonparametric method. Then, a subset of the training images, with a similar foreground to the input image, was selected. Consequently, the semantic labels could be further refined according to the subset. Finally, the input image was segmented by integrating the object affinity and refined semantic labels. State-of-the-art performance was achieved in experiments with the challenging MSRC 21 dataset.
Coordinated Repression In Vitro of the DivergentfepA-fes Promoters of Escherichia coli by the Iron Uptake Regulation (Fur) Protein

ABSTRACT The mechanism involved in transcriptional repression of thefepA-fes divergent promoters of Escherichia coli by the Fur (ferric uptake regulation) protein has been examined in vitro. This DNA region includes a suboptimal and single Fur-binding site with two divergent and overlapped −35/−10 hexamers. Comparison of transcription patterns generated with runoff experiments in either the presence or the absence of heparin showed that access of the RNA polymerase to the principal −35/−10 hexamers was fully prevented by Fur-Mn2+ bound to its target site within the divergent promoter region. Neither RNA polymerase bound to the fes and fepA promoters could be displaced by Fur-Mn2+, nor could the bound repressor be outcompeted by an excess of the enzyme. However, the repressor blocked reinitiation as soon as the polymerase moved away from the fes promoter during transcription. The spatial distribution of regulatory elements within the DNA region allowed the simultaneous binding of the RNA polymerase to the fes andfepA promoters and their coordinate regulation regardless of their different transcriptional activities. Comparisons with other iron-regulated systems support a general mechanism for Fur-controlled promoters that implies a direct competition between the polymerase and the regulator for overlapping target sites in the DNA.
Shot Boundary Detection in Soccer Video using Twin-comparison Algorithm and Dominant Color Region

The first step in generic video processing is temporal segmentation, i.e. shot boundary detection. Camera shot transitions can be either abrupt (e.g. cuts) or gradual (e.g. fades, dissolves, wipes). Sports video is one of the most challenging domains for robust shot boundary detection. We proposed a shot boundary detection algorithm for soccer video based on the twin-comparison method and the absolute difference between frames in their ratios of dominant colored pixels to total number of pixels. With this approach the detection of gradual transitions is improved by decreasing the number of false positives caused by some camera operations. We also compared performances of our algorithm and the standard twin-comparison method.