Miracle-dz/UniFAR-FTUs huggingface dataset:
An x-ray image guidance system for small animal stereotactic irradiation

An x-ray image-guided small animal stereotactic irradiator was developed and characterized to enable tumor visualization and accurate target localization for small field, high dose irradiation. The system utilizes a custom collimation system, a motorized positioning system (x, y, θ), a digital imaging panel and operating software, and is integrated with a commercial x-ray unit. The essential characteristics of the irradiator include small radiation fields (1–10 mm), high dose rate (>10 Gy min−1) and submillimeter target localization. The software enables computer-controlled image acquisition, stage motion and target localization providing simple and precise automated target localization. The imaging panel was characterized in terms of signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and spatial resolution. Overall localization accuracy and precision were assessed. SNR, CNR and spatial resolution are 24 dB, 21 dB and 2.8 lp mm−1, respectively, and localization accuracy is approximately 65 µm with 6 µm precision. With the aid of image guidance, system performance was subsequently used to evaluate radiation response in a rat orthotopic lung tumor effectively sparing normal tissues and in a mouse normal lung. The capabilities of 3D treatment and cone-beam computed tomography are presented for 3D localization and delivery as a work in progress.
Experiencing Blackboard as an Educational and Communication Tool at University of Bahrain: A Student's Perspectives

This experimental study covers Black Board (BB) as an e-learning tool aiming to investigate its' usefulness and ease of use as reported by student users and the possibility of utilizing BB to support the collaboration environment. It surveyed 81 undergraduate students from Information Technology (IT) college at the University of Bahrain (UOB), using standard questionnaire which is divided under four main elements: demographic information, Usage and interests of BB, Attitude toward using BB, and the E-learning center support. A descriptive analysis is used to analyze data collected by means of using Google application tool (on-line Google form) and SPSS statistical package to calculate frequencies, means, percentages, and standard deviations, correlations, t-test and F-test for variables. The overall results indicated that the students found BB, as a useful tool for obtaining class materials, submitting homework and assignments, taking quizzes and tests, preparing a project, and a helpful tool in raising the productivity, and easy to use. It is indicated that students' experience will influence the students' perceived ease of use and perceived usefulness.
Farmersâ€™ quality assessment of their crops and its impact on commercialization behavior: A field experiment in Ethiopia

Adoption of quality-enhancing technologies is often driven largely by farmersâ€™ expected returns from these technologies. Without proper grades, standards, and certification systems, however, farmers may remain uncertain about the actual financial return associated with their quality-enhancing investments. This report summarizes the outcomes of a short video-based randomized training intervention on wheat quality measurement and collective marketing among 15,000 wheat farmers in Ethiopia. Our results suggest that the intervention led to significant changes in farmersâ€™ commercialization behaviorsâ€”namely, it prompted farmers to adopt behaviors geared toward assessing their wheatâ€™s quality using easily implementable test-weight measures, assessing the accuracy of the equipment used by buyers in their kebeles (scales, in particular), and contacting more than one buyer before concluding a sale. The training also led to improvements in share of output sold, price received, and collective marketing, albeit with important limitations. First, farmers who measured their wheat quality received a higher price, but only if their wheat was of higher quality. Second, farmers who found that their wheat was of higher quality were more reluctant to aggregate their wheat (that is, sell their products through local cooperatives) than those who found that their wheat was of lower quality. Lastly, the training intervention led to better use of fertilizer in the following season. Our discovery that a short training intervention can significantly change farmersâ€™ marketing and production behavior should encourage the development of further interventions aimed at enhancing farmersâ€™ adoption of improved technologies and commercialization.
How do fishery policies affect Hawaii's longline fishing industry? Calibrating a positive mathematical programming model

We present a vessel and target‐specific positive mathematical programming model (PMP) for Hawaii's longline fishing fleet. Although common in agricultural economics, PMP modeling is rarely attempted in fisheries. To demonstrate the flexibility of the PMP framework, we separate tuna and swordfish production technologies into three policy‐relevant fishing targets. We find the model most accurately predicts vessel‐specific annual bigeye catch in the Western Central Pacific Ocean (WCPO), with an accuracy of 12–35%, and a correlation between 0.30 and 0.53. To demonstrate the model's usefulness to policy makers, we simulate the impact to individual vessels from increasing and decreasing the bigeye catch limit in the WCPO by 10%. Our results suggest that such policy changes will have moderate impacts on most vessels, but large impacts on a few generating a fat‐tailed distribution. These results offer insights into the range of winners and losers resulting from changes in fishery policies, and therefore, which policies are more likely to gain widespread industry support. As a tool for fishery management, the calibrated PMP model offers a flexible and easy‐to‐use framework, capable of capturing the heterogeneous response of fishing vessels to evaluate policy changes.
Deep Learning on Sparse Manifolds for Faster Object Segmentation

We propose a new combination of deep belief networks and sparse manifold learning strategies for the 2D segmentation of non-rigid visual objects. With this novel combination, we aim to reduce the training and inference complexities while maintaining the accuracy of machine learning-based non-rigid segmentation methodologies. Typical non-rigid object segmentation methodologies divide the problem into a rigid detection followed by a non-rigid segmentation, where the low dimensionality of the rigid detection allows for a robust training (i.e., a training that does not require a vast amount of annotated images to estimate robust appearance and shape models) and a fast search process during inference. Therefore, it is desirable that the dimensionality of this rigid transformation space is as small as possible in order to enhance the advantages brought by the aforementioned division of the problem. In this paper, we propose the use of sparse manifolds to reduce the dimensionality of the rigid detection space. Furthermore, we propose the use of deep belief networks to allow for a training process that can produce robust appearance models without the need of large annotated training sets. We test our approach in the segmentation of the left ventricle of the heart from ultrasound images and lips from frontal face images. Our experiments show that the use of sparse manifolds and deep belief networks for the rigid detection stage leads to segmentation results that are as accurate as the current state of the art, but with lower search complexity and training processes that require a small amount of annotated training data.
Impact of Initial Central Venous Pressure on Outcomes of Conservative Versus Liberal Fluid Management in Acute Respiratory Distress Syndrome

Objectives:In acute respiratory distress syndrome, conservative fluid management increases ventilator-free days without affecting mortality. Response to fluid management may differ based on patients’ initial central venous pressure. We hypothesized that initial central venous pressure would modify the effect of fluid management on outcomes. Design:Retrospective analysis of the Fluid and Catheter Treatment Trial, a multicenter randomized trial comparing conservative with liberal fluid management in acute respiratory distress syndrome. We examined the relationship between initial central venous pressure, fluid strategy, and 60-day mortality in univariate and multivariable analysis. Setting:Twenty acute care hospitals. Patients:Nine hundred thirty-four ventilated acute respiratory distress syndrome patients with a central venous pressure available at enrollment, 609 without baseline shock (for whom fluid balance was managed by the study protocol). Interventions:None. Measurements and Main Results:Among patients without baseline shock, those with initial central venous pressure greater than 8 mm Hg experienced similar mortality with conservative and liberal fluid management (18% vs 18%; p = 0.928), whereas those with central venous pressure of 8 mm Hg or less experienced lower mortality with a conservative strategy (17% vs 36%; p = 0.005). Multivariable analysis demonstrated an interaction between initial central venous pressure and the effect of fluid strategy on mortality (p = 0.031). At higher initial central venous pressures, the difference in treatment between arms was predominantly furosemide administration, which was not associated with mortality (p = 0.122). At lower initial central venous pressures, the difference between arms was predominantly fluid administration, with additional fluid associated with increased mortality (p = 0.013). Conclusions:Conservative fluid management decreases mortality for acute respiratory distress syndrome patients with a low initial central venous pressure. In this population, the administration of IV fluids seems to increase mortality.
Working memory deficits of reading disabled children.

Aims of the study were to investigate the specificity of reading disabled childrens deficits in working memory capacity and to pursue whether their deficits could be accounted for by deficient processing or impairments in verbal short-term storage capacity. A group of 10-year-old reading disabled children was compared with two groups of normal reading children, matched for chronological age and reading age, respectively. Measures for working memory capacity, short-term capacity and processing speed related to the language and to the numerical domain were administered. Results indicated that reading disabled children performed worse on all measures of working memory capacity, irrespective of the domain which these measures reflected. Their poorer performance could neither be explained by inefficient processing nor to their deficits in verbal short-term storage capacity. Reading disabled children seem to have a general lack of capacity for the concurrent processing and storage of verbal information.
Cytokinin Response Factor 6 Represses Cytokinin-Associated Genes during Oxidative Stress1[OPEN]

Arabidopsis CYTOKININ RESPONSE FACTOR 6 represses a module of cytokinin-associated genes during exposure to oxidative stress. Cytokinin is a phytohormone that is well known for its roles in numerous plant growth and developmental processes, yet it has also been linked to abiotic stress response in a less defined manner. Arabidopsis (Arabidopsis thaliana) Cytokinin Response Factor 6 (CRF6) is a cytokinin-responsive AP2/ERF-family transcription factor that, through the cytokinin signaling pathway, plays a key role in the inhibition of dark-induced senescence. CRF6 expression is also induced by oxidative stress, and here we show a novel function for CRF6 in relation to oxidative stress and identify downstream transcriptional targets of CRF6 that are repressed in response to oxidative stress. Analysis of transcriptomic changes in wild-type and crf6 mutant plants treated with H2O2 identified CRF6-dependent differentially expressed transcripts, many of which were repressed rather than induced. Moreover, many repressed genes also show decreased expression in 35S:CRF6 overexpressing plants. Together, these findings suggest that CRF6 functions largely as a transcriptional repressor. Interestingly, among the H2O2 repressed CRF6-dependent transcripts was a set of five genes associated with cytokinin processes: (signaling) ARR6, ARR9, ARR11, (biosynthesis) LOG7, and (transport) ABCG14. We have examined mutants of these cytokinin-associated target genes to reveal novel connections to oxidative stress. Further examination of CRF6-DNA interactions indicated that CRF6 may regulate its targets both directly and indirectly. Together, this shows that CRF6 functions during oxidative stress as a negative regulator to control this cytokinin-associated module of CRF6-dependent genes and establishes a novel connection between cytokinin and oxidative stress response.
From lateral to mesial: The quest for a surgical cure for temporal lobe epilepsy

Purpose: A gap of more than a hundred years occurred between the first accounts of mesial temporal sclerosis and recognition of its role in the pathogenesis of psychomotor seizures. This paper reviews how the understanding and surgical treatment of temporal lobe epilepsy developed, particularly from the work of Penfield, Jasper, and their associates at the Montreal Neurological Institute (MNI).
6‐Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones

6‐Hydroxykynurenic acid (6‐HKA), a derivative of kynurenic acid (KYNA) extracted from Ginkgo biloba leaves, was tested for its putative glutamate receptor (GluR) antagonism in comparison to the scaffold substance. The patch‐clamp method together with fast‐application techniques were used to estimate inhibition by 6‐HKA and KYNA of agonist binding at NMDA and α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptors (NMDARs and AMPARs) of CA1 pyramidal neurones. 6‐Hydroxykynurenic acid proved to be a low‐affinity antagonist. When comparing with KYNA, 6‐HKA was less potent at NMDARs (IC50 = 136 versus 59 µm), but showed a higher affinity to AMPARs (KB = 22 versus 172 µm). The replacement of 6‐HKA and KYNA by glutamate was investigated on outside‐out patches. Both antagonists competitively inhibited AMPAR responses and displayed fast unbinding kinetics, but the derivative was significantly slower displaced than KYNA (τ = 1.63 versus 1.22 ms). Our findings demonstrate that 6‐hydroxylation considerably changes the pharmacological profile of KYNA. Among the 6‐derivatives of KYNA, 6‐HKA shows the highest affinity to AMPARs. Despite its relatively low lipophily, these properties might be of clinical relevance under conditions that compromise the integrity of the blood–brain barrier. Furthermore, 6‐HKA should be a useful tool to analyse glutamate‐mediated synaptic responses.
Accuracy of forward freight agreements in forecasting future freight rates

ABSTRACT Participants in the maritime industry place much interest in the Forward Freight Agreements (FFA/FFAs), being an indispensable tool for hedging shipping freight risk. Our article innovates by directly comparing the FFA predictions with their actual future settlement prices as well as by examining contracts going forward as far as next calendar year. We combine straightforward comparison measurements with cointegration analysis to test for the accuracy and efficiency of the FFA projections. We find that FFAs display limited usefulness in predicting future freights, only slightly superior than simple naïve models. The shorter the contract period and the smaller the vessel the better the forecast. We also find FFAs being relatively good predictors of future market direction but missing the turning points of the market cycles.
A comparative analysis of Pancoast tumour resection performed via video-assisted thoracic surgery versus standard open approaches.

OBJECTIVES The aim of the present paper was to conduct a comparative analysis of outcomes after thoracoscopic resection versus standard thoracotomy approach in the treatment of Pancoast tumours. METHODS All consecutive patients with Pancoast tumours undergoing surgical treatment from March 2000 to November 2012 were enrolled. Patients were divided into 2 groups according to whether a thoracoscopic or standard thoracotomy approach was adopted. In addition to morbidity and mortality, (i) intensity of pain; (ii) respiratory function focusing on the postoperative value and its variation with respect to the predicted value (Delta); (iii) analgesic consumption at different times during the postoperative course; and (iiii) survival rate were recorded in both groups and the inter-group differences were statistically compared. RESULTS Of the 45 enrolled patients, 34 (75%) were included in the final analysis (18 in the thoracoscopic group and 16 in the standard group). Eleven (25%) patients were excluded because they (i) were unfit for surgery after induction therapy (n = 4); (ii) refused the operation (n = 1) or (iii) had unexpected pleural involvement (n = 6). Compared with the standard group, in the thoracoscopic group we observed less pain (P = 0.01), better recovery of forced vital capacity (P = 0.01) and forced expiratory value in 1 s (P < 0.001), and a reduction in opioid (P = 0.01) and analgesic consumption (P = 0.02). The median survival for all patients was 15 months. Patients with N0/N1 disease had better median survival than N2 patients (47 vs 9 months; P = 0.009). One local recurrence in the standard group was observed 1 year after operation, whereas 2 local recurrences, 1 in the thoracoscopic group and another in the standard group, were registered 2 years after the operation (P = 1.0). Finally, 4 (22%) extrathoracic metastases in the thoracoscopic group and 5 (31%) in the standard group (P = 0.8) were found over the 2 years following the procedure. CONCLUSIONS In the management of Pancoast tumours, a thoracoscopic approach is safe and may be an effective adjunct to standard surgical resection in selected cases. Such an approach enabled surgeons to explore the pleural cavity and avoid exploratory thoracotomy in cases of unexpected pleural involvement.
Prospective Evaluation of Neuromediator Dynamics in Castration-Resistant Prostate Cancer Patients During Docetaxel.

AIM Aim of the study was to detect small cell/neuroendocrine (SCNC) transformation in metastatic castration-resistant prostate cancer (mCRPC) that is a challenging procedure. We investigated the role of neuromediator dynamics as potential evidence of SCNC in patients undergoing docetaxel therapy. PATIENTS AND METHODS A multi-institutional, prospective observational study was conducted. Patients undergoing docetaxel treatment were included. Chromogranin A (CGA), neuron-specific enolase (NSE), and pro-gastrin releasing peptide (Pro-GRP) were sequentially evaluated at predefined time points. Outcome measures were overall survival (OS), progression-free survival (PFS) and PSA nadir. RESULTS Fifty-two patients were included. A general rise in CGA levels was observed. Patients with a high CGA rise (100%ULN: CGA ≥98.1ng/ml) between the 1st and 3rd cycle trended towards a decreased OS (p=0.0649) and showed a decreased PFS (p=0.0369). In multivariate analysis, continuous CGA rise correlated with PFS (p=0.0553; HR 1.136), but was not an independent predictor of OS. CONCLUSION Patients with an early high CGA rise may demonstrate a subgroup with poor outcome due to underlying SCNC transformation. Monitoring of CGA appears to be an option worth considering.
Considerations affecting dietary behaviour of immigrants with type 2 diabetes: a qualitative study among Surinamese in the Netherlands

Purpose. The purpose of this study was to explore the sociocultural factors affecting the dietary behaviour of Dutch Surinamese patients with type 2 diabetes. Methods. In this qualitative study, 32 Surinamese primary care patients with type 2 diabetes mellitus participated in semi-structured interviews (16 African Surinamese and 16 Hindustani Surinamese). Interviews were recorded and transcripts were analysed and coded into themes using principles of grounded theory and MAXQDA software. Results. Surinamese food was eaten regularly by all respondents. Most participants were aware of the need to change their diet but reported difficulty with changing their dietary behaviour to meet dietary guidelines. Many perceived these guidelines to be based on Dutch eating habits, making it difficult to reconcile them with Surinamese cooking and eating practices. Firstly, respondents indicated that they did not choose foods based on their nutritional qualities. Instead, choices were based on Surinamese beliefs regarding ‘good’ (e.g., bitter vegetables) or ‘bad’ (e.g., spicy dishes) foods for diabetes. Secondly, respondents often perceived recommendations such as eating at fixed times as interfering with traditional values, for example hospitality. Above all, the maintenance of Surinamese cooking and eating practices was regarded as extremely important since the respondents perceived these to be a core element of their identity as Surinamese. Conclusions. For Surinamese diabetes patients, cooking and eating practices are related to deeply rooted cultural beliefs and values. The wish to maintain one's Surinamese identity may pose difficulty for patients’ adherence to dietary guidelines, as these are perceived as being based on ‘Dutch’ habits. This suggests that immigrants with a long duration of residence in the host country like the Surinamese, who are seen as well integrated might benefit from culturally sensitive diabetes education that is adapted at surface and deep structure.
Carotid and Femoral Arterial Wall Distensibility During Long-Duration Spaceflight.

INTRODUCTION This study aimed to assess changes in common carotid (CA) and superficial femoral (FA) arterial stiffness during long-duration spaceflight. METHODS Ultrasound imaging was used to investigate the CA and FA of 10 astronauts preflight (PRE), on flight day 15 (FD15), after 4-5 mo (FD4-5m), and 4 d after return to Earth (R+4). Arterial wall properties were assessed through the calculation of strain, stiffness (β), pressure-strain elastic modulus (Ep), and distensibility (DI). Stiffness indices were assessed for potential correlations to measurements of intima-media thickness (IMT). RESULTS Significant effects of spaceflight were found for all CA stiffness indices, indicating an increase in arterial stiffness. CA strain was reduced by 34 ± 31% on FD15 and 50 ± 16% on FD4-5m and remained reduced by 42 ± 14% on R+4 with respect to PRE values. On FD4-5m, with respect to PRE values, DI was reduced by 46 ± 25% and β and Ep were increased by 124 ± 95% and 118 ± 92%, respectively. FA arterial stiffness indices appeared to show similar changes; however, a main effect of spaceflight was only found for strain. Correlation analysis showed weak but significant relationships between measurements of CA IMT and arterial stiffness indices, but no relationships were found for FA measurements. DISCUSSION The observed change in CA and FA stiffness indices suggest that spaceflight results in an increase in arterial stiffness. That these changes were not strongly related to measurements of IMT suggests the possibility of different mechanisms contributing to the observed results.Arbeille P, Provost R, Zuj K. Carotid and femoral arterial wall distensibility during long-duration spaceflight. Aerosp Med Hum Perform. 2017; 88(10):924-930.